WorldWideScience

Sample records for factors generally exhibited

  1. VNU Exhibitions Asia: Two factors are crucial

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Reporter: How to appraises the Chinese exhibition industry market? Jime Essink :The Chinese exhibition market will experience a fast growth in the coming years. This will mainly be the result of an increase of international visitors who

  2. General Factors in Graphs.

    Science.gov (United States)

    1986-07-01

    conjectured that the general factor problem can be solved in polynomial time when, in each Bi, all the gaps (if any) have length one. We prove this conjecture...exactly bi edges incident with node i, for each i. This problem is well-solved. A polynomial algorithm is known (Edmonds and Johnson (1970)) as well as a...powerful theorem to characterize the existence of solutions ( Tutte (1952)). The following generalization of the factor problem was studied by Lovtsz

  3. Exhibition

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    China[Guangzheu] International Trade Fair for Home Textiles Date:March 18th- March 21st,2011 Venue:China Import and Export Fair Complex(Guangzhou,China) Organizers:China National Textile&Apparel Council China Foreign Trade Center(Group) China Home Textile Association China Foreign Trade Guangzhou Exhibition Corp.

  4. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    A Look of Hope Islam Mahmoud Sweity From 19 to 30 June 2017 CERN Meyrin, Main Building Islam Mahmoud Sweity Islam Mahmoud Sweity was born in 1997 at Beit Awwa, Palestine. She is currently following a course to get an Art diploma of Painting at the college of Fine Arts at An-Najah National University under the supervision of Esmat Al As'aad. Her portraits, landscapes and still life paintings are full of life and shining colours. Charged of emotional empathy they catch the attention of the viewer and are reminding us that life is beautiful and worth living in spite of all difficulties we have to go through. She participated in many exhibitions and has exposed her drawings in 2015 at CERN and in France in the framework of the exhibition "The Origin“, and in 2017 in the Former Yugoslav Republic of Macedonia, Palestina and Jordan. In this exhibition the oil paintings made in the past year will be presented. For more information : staff.association@cern.ch | T&eacu...

  5. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    Encounters Hanne Blitz From February 1st to 12th 2016 CERN Meyrin, Main Building What is our reaction to a first encounter with a tourist attraction? Contemporary Dutch painter Hanne Blitz captures visitors' responses to art and architecture, sweeping vistas and symbolic memorials. Encounters, a series of oil paintings curated specially for this CERN exhibition, depicts tourists visiting cultural highlights around the world. A thought-provoking journey not to be missed, and a tip of the hat to CERN's large Hadron Collider.

  6. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Sintropie Flavio Pellegrini From 13 to 24 March 2017 CERN Meyrin, Main Building Energia imprigionata - Flavio Pellegrini. The exhibition is composed by eleven wood artworks with the expression of movement as theme. The artworks are the result of harmonics math applied to sculpture. The powerful black colour is dominated by the light source, generating reflexes and modulations. The result is a continuous variation of perspective visions. The works generate, at a first approach, an emotion of mystery and incomprehension, only a deeper contemplation lets one discover entangling and mutative details, evidencing the elegance of the lines and letting the meaning emerge. For more information : staff.association@cern.ch | Tél: 022 766 37 38

  7. Transcription Factors Exhibit Differential Conservation in Bacteria with Reduced Genomes.

    Science.gov (United States)

    Galán-Vásquez, Edgardo; Sánchez-Osorio, Ismael; Martínez-Antonio, Agustino

    2016-01-01

    The description of transcriptional regulatory networks has been pivotal in the understanding of operating principles under which organisms respond and adapt to varying conditions. While the study of the topology and dynamics of these networks has been the subject of considerable work, the investigation of the evolution of their topology, as a result of the adaptation of organisms to different environmental conditions, has received little attention. In this work, we study the evolution of transcriptional regulatory networks in bacteria from a genome reduction perspective, which manifests itself as the loss of genes at different degrees. We used the transcriptional regulatory network of Escherichia coli as a reference to compare 113 smaller, phylogenetically-related γ-proteobacteria, including 19 genomes of symbionts. We found that the type of regulatory action exerted by transcription factors, as genomes get progressively smaller, correlates well with their degree of conservation, with dual regulators being more conserved than repressors and activators in conditions of extreme reduction. In addition, we found that the preponderant conservation of dual regulators might be due to their role as both global regulators and nucleoid-associated proteins. We summarize our results in a conceptual model of how each TF type is gradually lost as genomes become smaller and give a rationale for the order in which this phenomenon occurs.

  8. Transcription Factors Exhibit Differential Conservation in Bacteria with Reduced Genomes.

    Directory of Open Access Journals (Sweden)

    Edgardo Galán-Vásquez

    Full Text Available The description of transcriptional regulatory networks has been pivotal in the understanding of operating principles under which organisms respond and adapt to varying conditions. While the study of the topology and dynamics of these networks has been the subject of considerable work, the investigation of the evolution of their topology, as a result of the adaptation of organisms to different environmental conditions, has received little attention. In this work, we study the evolution of transcriptional regulatory networks in bacteria from a genome reduction perspective, which manifests itself as the loss of genes at different degrees. We used the transcriptional regulatory network of Escherichia coli as a reference to compare 113 smaller, phylogenetically-related γ-proteobacteria, including 19 genomes of symbionts. We found that the type of regulatory action exerted by transcription factors, as genomes get progressively smaller, correlates well with their degree of conservation, with dual regulators being more conserved than repressors and activators in conditions of extreme reduction. In addition, we found that the preponderant conservation of dual regulators might be due to their role as both global regulators and nucleoid-associated proteins. We summarize our results in a conceptual model of how each TF type is gradually lost as genomes become smaller and give a rationale for the order in which this phenomenon occurs.

  9. A peptide factor secreted by Staphylococcus pseudintermedius exhibits properties of both bacteriocins and virulence factors

    Science.gov (United States)

    Wladyka, Benedykt; Piejko, Marcin; Bzowska, Monika; Pieta, Piotr; Krzysik, Monika; Mazurek, Łukasz; Guevara-Lora, Ibeth; Bukowski, Michał; Sabat, Artur J.; Friedrich, Alexander W.; Bonar, Emilia; Międzobrodzki, Jacek; Dubin, Adam; Mak, Paweł

    2015-01-01

    Staphylococcus pseudintermedius is a common commensal bacterium colonizing the skin and mucosal surfaces of household animals. However, it has recently emerged as a dangerous opportunistic pathogen, comparable to S. aureus for humans. The epidemiological situation is further complicated by the increasing number of methicillin-resistant S. pseudintermedius infections and evidence of gene transmission driving antibiotic resistance between staphylococci colonizing human and zoonotic hosts. In the present study, we describe a unique peptide, BacSp222, that possesses features characteristic of both bacteriocins and virulence factors. BacSp222 is secreted in high quantities by S. pseudintermedius strain 222 isolated from dog skin lesions. This linear, fifty-amino-acid highly cationic peptide is plasmid-encoded and does not exhibit significant sequence similarities to any other known peptides or proteins. BacSp222 kills gram-positive bacteria (at doses ranging from 0.1 to several micromol/l) but also demonstrates significant cytotoxic activities towards eukaryotic cells at slightly higher concentrations. Moreover, at nanomolar concentrations, the peptide also possesses modulatory properties, efficiently enhancing interferon gamma-induced nitric oxide release in murine macrophage-like cell lines. BacSp222 appears to be one of the first examples of multifunctional peptides that breaks the convention of splitting bacteriocins and virulence factors into two unrelated groups. PMID:26411997

  10. A peptide factor secreted by Staphylococcus pseudintermedius exhibits properties of both bacteriocins and virulence factors.

    Science.gov (United States)

    Wladyka, Benedykt; Piejko, Marcin; Bzowska, Monika; Pieta, Piotr; Krzysik, Monika; Mazurek, Łukasz; Guevara-Lora, Ibeth; Bukowski, Michał; Sabat, Artur J; Friedrich, Alexander W; Bonar, Emilia; Międzobrodzki, Jacek; Dubin, Adam; Mak, Paweł

    2015-09-28

    Staphylococcus pseudintermedius is a common commensal bacterium colonizing the skin and mucosal surfaces of household animals. However, it has recently emerged as a dangerous opportunistic pathogen, comparable to S. aureus for humans. The epidemiological situation is further complicated by the increasing number of methicillin-resistant S. pseudintermedius infections and evidence of gene transmission driving antibiotic resistance between staphylococci colonizing human and zoonotic hosts. In the present study, we describe a unique peptide, BacSp222, that possesses features characteristic of both bacteriocins and virulence factors. BacSp222 is secreted in high quantities by S. pseudintermedius strain 222 isolated from dog skin lesions. This linear, fifty-amino-acid highly cationic peptide is plasmid-encoded and does not exhibit significant sequence similarities to any other known peptides or proteins. BacSp222 kills gram-positive bacteria (at doses ranging from 0.1 to several micromol/l) but also demonstrates significant cytotoxic activities towards eukaryotic cells at slightly higher concentrations. Moreover, at nanomolar concentrations, the peptide also possesses modulatory properties, efficiently enhancing interferon gamma-induced nitric oxide release in murine macrophage-like cell lines. BacSp222 appears to be one of the first examples of multifunctional peptides that breaks the convention of splitting bacteriocins and virulence factors into two unrelated groups.

  11. General introduction and recovery factors

    Science.gov (United States)

    Verma, Mahendra K.

    2017-07-17

    IntroductionThe U.S. Geological Survey (USGS) compared methods for estimating an incremental recovery factor (RF) for the carbon dioxide enhanced oil recovery (CO2-EOR) process involving the injection of CO2 into oil reservoirs. This chapter first provides some basic information on the RF, including its dependence on various reservoir and operational parameters, and then discusses the three development phases of oil recovery—primary, second­ary, and tertiary (EOR). It ends with a brief discussion of the three approaches for estimating recovery factors, which are detailed in subsequent chapters.

  12. A general psychopathology factor in early adolescence.

    Science.gov (United States)

    Patalay, Praveetha; Fonagy, Peter; Deighton, Jessica; Belsky, Jay; Vostanis, Panos; Wolpert, Miranda

    2015-07-01

    Recently, a general psychopathology dimension reflecting common aspects among disorders has been identified in adults. This has not yet been considered in children and adolescents, where the focus has been on externalising and internalising dimensions. To examine the existence, correlates and predictive value of a general psychopathology dimension in young people. Alternative factor models were estimated using self-reports of symptoms in a large community-based sample aged 11-13.5 years (N = 23 477), and resulting dimensions were assessed in terms of associations with external correlates and future functioning. Both a traditional two-factor model and a bi-factor model with a general psychopathology bi-factor fitted the data well. The general psychopathology bi-factor best predicted future psychopathology and academic attainment. Associations with correlates and factor loadings are discussed. A general psychopathology factor, which is equal across genders, can be identified in young people. Its associations with correlates and future functioning indicate that investigating this factor can increase our understanding of the aetiology, risk and correlates of psychopathology. © The Royal College of Psychiatrists 2015.

  13. Tour of the stands at the UK@CERN industrial exhibition with the Director-General and H.E. Mr Simon Featherstone, HM Ambassador to Switzerland, hosted by Mrs. Jan Fillingham MBE, Head of Exhibitions, BEAMA

    CERN Document Server

    Claudia Marcelloni

    2006-01-01

    Tour of the stands at the UK@CERN industrial exhibition with the Director-General and H.E. Mr Simon Featherstone, HM Ambassador to Switzerland, hosted by Mrs. Jan Fillingham MBE, Head of Exhibitions, BEAMA

  14. From form factors to generalized parton distributions

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, Markus

    2013-06-15

    I present an extraction of generalized parton distributions from selected data on the electromagnetic nucleon form factors. The extracted distributions can in particular be used to quantify the contribution to the proton spin from the total angular momentum carried by valence quarks, as well as their transverse spatial distribution inside the proton.

  15. Military Personnel Exhibit a Lower Presence of Obesity than the General U.S. Adult Population

    Science.gov (United States)

    2013-06-01

    307 Rankinen T & Bouchard C (2004) Fitness alters the associations of BMI and 308 waist circumference with total and abdominal fat. Obesity...either group. 152 Active duty military personnel are not included in the U.S. CDC national surveys 153 [e.g., NHANES, Behavioral Risk Factor

  16. Equivalent theories redefine Hamiltonian observables to exhibit change in general relativity

    Science.gov (United States)

    Pitts, J. Brian

    2017-03-01

    Change and local spatial variation are missing in canonical General Relativity’s observables as usually defined, an aspect of the problem of time. Definitions can be tested using equivalent formulations of a theory, non-gauge and gauge, because they must have equivalent observables and everything is observable in the non-gauge formulation. Taking an observable from the non-gauge formulation and finding the equivalent in the gauge formulation, one requires that the equivalent be an observable, thus constraining definitions. For massive photons, the de Broglie–Proca non-gauge formulation observable {{A}μ} is equivalent to the Stueckelberg–Utiyama gauge formulation quantity {{A}μ}+{{\\partial}μ}φ, which must therefore be an observable. To achieve that result, observables must have 0 Poisson bracket not with each first-class constraint, but with the Rosenfeld–Anderson–Bergmann–Castellani gauge generator G, a tuned sum of first-class constraints, in accord with the Pons–Salisbury–Sundermeyer definition of observables. The definition for external gauge symmetries can be tested using massive gravity, where one can install gauge freedom by parametrization with clock fields X A . The non-gauge observable {{g}μ ν} has the gauge equivalent {{X}A}{{,}μ}{{g}μ ν}{{X}B}{{,}ν}. The Poisson bracket of {{X}A}{{,}μ}{{g}μ ν}{{X}B}{{,}ν} with G turns out to be not 0 but a Lie derivative. This non-zero Poisson bracket refines and systematizes Kuchař’s proposal to relax the 0 Poisson bracket condition with the Hamiltonian constraint. Thus observables need covariance, not invariance, in relation to external gauge symmetries. The Lagrangian and Hamiltonian for massive gravity are those of General Relativity  +   Λ   +  4 scalars, so the same definition of observables applies to General Relativity. Local fields such as {{g}μ ν} are observables. Thus observables change. Requiring equivalent observables for equivalent theories also recovers

  17. On Factorization of Generalized Macdonald Polynomials

    CERN Document Server

    Kononov, Ya

    2016-01-01

    A remarkable feature of Schur functions -- the common eigenfunctions of cut-and-join operators from $W_\\infty$ -- is that they factorize at the peculiar two-parametric topological locus in the space of time-variables, what is known as the hook formula for quantum dimensions of representations of $U_q(SL_N)$ and plays a big role in various applications. This factorization survives at the level of Macdonald polynomials. We look for its further generalization to generalized Macdonald polynomials (GMP), associated in the same way with the toroidal Ding-Iohara-Miki algebras, which play the central role in modern studies in Seiberg-Witten-Nekrasov theory. In the simplest case of the first-coproduct eigenfunctions, where GMP depend on just two sets of time-variables, we discover a weak factorization -- on a one- (rather than four-) parametric slice of the topological locus, what is already a very non-trivial property, calling for proof and better understanding.

  18. On factorization of generalized Macdonald polynomials

    Energy Technology Data Exchange (ETDEWEB)

    Kononov, Ya. [Landau Institute for Theoretical Physics, Chernogolovka (Russian Federation); HSE, Math Department, Moscow (Russian Federation); Morozov, A. [ITEP, Moscow (Russian Federation); Institute for Information Transmission Problems, Moscow (Russian Federation); National Research Nuclear University MEPhI, Moscow (Russian Federation)

    2016-08-15

    A remarkable feature of Schur functions - the common eigenfunctions of cut-and-join operators from W{sub ∞} - is that they factorize at the peculiar two-parametric topological locus in the space of time variables, which is known as the hook formula for quantum dimensions of representations of U{sub q}(SL{sub N}) and which plays a big role in various applications. This factorization survives at the level of Macdonald polynomials. We look for its further generalization to generalized Macdonald polynomials (GMPs), associated in the same way with the toroidal Ding-Iohara-Miki algebras, which play the central role in modern studies in Seiberg-Witten-Nekrasov theory. In the simplest case of the first-coproduct eigenfunctions, where GMP depend on just two sets of time variables, we discover a weak factorization - on a one- (rather than four-) parametric slice of the topological locus, which is already a very non-trivial property, calling for proof and better understanding. (orig.)

  19. Exhibit Engineering

    DEFF Research Database (Denmark)

    Mortensen, Marianne Foss

    ) a synthesis of the findings from the first two studies with findings from the literature to generate two types of results: a coherent series of suggestions for a design iteration of the studied exhibit as well as a more general normative model for exhibit engineering. Finally, another perspective...

  20. Mouse Proepicardium Exhibits a Sprouting Response to Exogenous Proangiogenic Growth Factors in vitro.

    Science.gov (United States)

    Niderla-Bielińska, Justyna; Ciszek, Bogdan; Jankowska-Steifer, Ewa; Flaht-Zabost, Aleksandra; Gula, Grzegorz; Radomska-Leśniewska, Dorota M; Ratajska, Anna

    2016-01-01

    Angiogenesis contributes to the generation of the vascular bed but also affects the progression of many diseases, such as tumor growth. Many details of the molecular pathways controlling angiogenesis are still undefined due to the lack of appropriate models. We propose the proepicardial explant as a suitable model for studying certain aspects of angiogenesis. The proepicardium (PE) is a transient embryonic structure that contains a population of undifferentiated endothelial cells (ECs) forming a vascular net continuous with the sinus venosus. In this paper, we show that PE explants give rise to CD31-positive vascular sprouts in the presence of basic fibroblast growth factor (bFGF) and 2 isoforms of vascular endothelial growth factor A (VEGF-A), i.e. VEGF-A120 and VEGF-A164. Vascular sprouts exhibit differences in number, length, thickness and the number of branches, depending on the combination of growth factors used. Moreover, the ECs of the sprouts express various levels of mRNA for Notch1 and its ligand Dll4. Additionally, stimulation with bFGF/VEGF-A164 upregulates the expression of Lyve-1 antigen in the ECs in the sprouts. In summary, we present a new model for angiogenesis studies involving mouse PE as a source of ECs. We believe that our model may act as a supplementary assay for angiogenesis studies along with the existing models.

  1. On factorization of generalized Macdonald polynomials

    Science.gov (United States)

    Kononov, Ya.; Morozov, A.

    2016-08-01

    A remarkable feature of Schur functions—the common eigenfunctions of cut-and-join operators from W_∞ —is that they factorize at the peculiar two-parametric topological locus in the space of time variables, which is known as the hook formula for quantum dimensions of representations of U_q(SL_N) and which plays a big role in various applications. This factorization survives at the level of Macdonald polynomials. We look for its further generalization to generalized Macdonald polynomials (GMPs), associated in the same way with the toroidal Ding-Iohara-Miki algebras, which play the central role in modern studies in Seiberg-Witten-Nekrasov theory. In the simplest case of the first-coproduct eigenfunctions, where GMP depend on just two sets of time variables, we discover a weak factorization—on a one- (rather than four-) parametric slice of the topological locus, which is already a very non-trivial property, calling for proof and better understanding.

  2. Soil factors exhibit greater influence than bacterial inoculation on alfalfa growth and nitrogen fixation.

    Science.gov (United States)

    Neumann, Ute; Kosier, Bob; Jahnke, Joachim; Priefer, Ursula B; Al-Halbouni, Djamila

    2011-09-01

    In order to study the effects of soil factors and bacterial inoculation on alfalfa (Medicago sativa), plants were inoculated with Ensifer meliloti L33 and Azospirillum brasilense Sp7 in pot experiments using two different soils separately as well as in a mixture. One soil was contaminated with chemical waste products; the other was an arable soil. Soil factors, including the availability of macro- and micronutrients as well as carbon and nitrogen contents, were found to exhibit a much greater influence on the growth of alfalfa than any of the inoculations. In contaminated soil, the shoot and root growth of alfalfa was decreased and nodules were diminished and ineffective. Bacterial inoculations did not significantly improve this hostile growth environment. However, in a mixture (44% arable, 22% contaminated soil, 34% vermiculite), growth conditions for alfalfa were improved so that shoot dry weight and nodule numbers increased up to 100- and 20-fold, respectively, compared with the contaminated soil. For the strain L33, its persistence in the rhizosphere was correlated to the presence of its host plant, but its dynamics were influenced by competition with indigenous rhizobia. The strain Sp7, once provided with a suitable soil, was not dependent on the plant's rhizosphere, but it enhanced the performance of L33 and native rhizobia.

  3. Salidroside exhibits anti-dengue virus activity by upregulating host innate immune factors.

    Science.gov (United States)

    Sharma, Navita; Mishra, K P; Ganju, Lilly

    2016-12-01

    Dengue is an arboviral disease with no effective therapy available. Therefore, there is an urgent need to find a potent antiviral agent against dengue virus (DENV). In the present study, salidroside, a main bioactive compound of Rhodiola rosea, was evaluated for its antiviral potential against DENV serotype-2 infection and its effect on host innate immune factors. Antiviral effects of salidroside were examined in DENV-infected cells by western blotting, flow cytometry and real-time PCR. Its underlying mechanism involved in antiviral action was determined by evaluating expression of host innate immune factors including RIG-I, IRF-3, IRF-7, PKR, P-eIF2α and NF-κB. Salidroside potently inhibited DENV infection by decreasing DENV envelope protein expression more than tenfold. Salidroside exerts its antiviral activity by increasing expression of RNA helicases such as RIG-I, thereby initiating a downstream signaling cascade that induces upregulation of IRF-3 and IRF-7. It prevents viral protein synthesis by increasing the expression of PKR and P-eIF2α while decreasing NF-κB expression. It was also found to induce the expression of IFN-α. In addition, the number of NK cells and CD8(+) T cells were also found to be increased by salidroside treatment in human PBMCs, which are important in limiting DENV replication during early stages of infection. The findings presented here suggest that salidroside exhibits antiviral activity against DENV by inhibiting viral protein synthesis and boosting host immunity by increasing the expression of host innate immune factors and hence could be considered for the development of an effective therapeutic agent against DENV infection.

  4. A diketopiperazine factor from Rheinheimera aquimaris QSI02 exhibits anti-quorum sensing activity

    Science.gov (United States)

    Sun, Shiwei; Dai, Xiaoyun; Sun, Jiao; Bu, Xiangguo; Weng, Caihong; Li, Hui; Zhu, Hu

    2016-01-01

    An ethyl acetate (EtOAc) extract isolated from the marine bacterium, Rheinheimera aquimaris QSI02, was found to exhibit anti-quorum sensing (anti-QS) activity. A subsequent bioassay-guided isolation protocol led to the detection of an active diketopiperazine factor, cyclo(Trp-Ser). Biosensor assay data showed that the minimum inhibitory concentration (MIC) of cyclo(Trp-Ser) ranged from 3.2 mg/ml to 6.4 mg/m for several microorganisms, including Escherichia coli, Chromobacterium violaceum CV026, Pseudomonas aeruginosa PA01, Staphylococcus aureus, and Candida albicans. Additionally, sub-MICs of cyclo(Trp-Ser) decreased the QS-regulated violacein production in C. violaceum CV026 by 67%. Furthermore, cyclo(Trp-Ser) can decrease QS-regulated pyocyanin production, elastase activity and biofilm formation in P. aeruginosa PA01 by 65%, 40% and 59.9%, respectively. Molecular docking results revealed that cyclo(Trp-Ser) binds to CviR receptor more rigidly than C6HSL with lower docking energy −8.68 kcal/mol, while with higher binding energy of −8.40 kcal/mol than 3-oxo-C12HSL in LasR receptor. Molecular dynamics simulation suggested that cyclo(Trp-Ser) is more easy to bind to CviR receptor than natural signaling molecule, but opposite in LasR receptor. These results suggest that cyclo(Trp-Ser) can be used as a potential inhibitor to control QS systems of C. violaceum and P. aeruginosa and provide increased the understanding of molecular mechanism that influences QS-regulated behaviors. PMID:28000767

  5. Human Factors Problems in General Aviation

    Science.gov (United States)

    1980-04-01

    of general aviation pilots, and, vhen relevant, pilots in general. This information was acquired through the use of both automated and manual searches... Bergey , 1978; Bolz and Eisele, 1979; FAA, 1979b; Smyth, 1980). These changes will result from a number of forces that are acting in concert to speed...not have been adequately addressed in the documentation. Literature Search. Both automated and manual search procedures were used in pursuit of a

  6. Prognostic factors for neckpain in general practice.

    NARCIS (Netherlands)

    Hoving, J.L.; Vet, H.C.W. de; Twisk, J.W.R.; Devillé, W.L.J.M.; Windt, D. van der; Koes, B.W.; Bouter, L.M.

    2004-01-01

    Prognostic studies on neck pain are scarce and are typically restricted to short-term follow-up only. In this prospective cohort study, indicators of short- and long-term outcomes of neck pain were identified that can easily be measured in general practice. Patients between 18 and 70 years of age, s

  7. Evidence for a General Factor Model of ADHD in Adults

    Science.gov (United States)

    Gibbins, Christopher; Toplak, Maggie E.; Flora, David B.; Weiss, Margaret D.; Tannock, Rosemary

    2012-01-01

    Objective: To examine factor structures of "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.) symptoms of ADHD in adults. Method: Two sets of models were tested: (a) models with inattention and hyperactivity/impulsivity as separate but correlated latent constructs and (b) hierarchical general factor models with a general factor for…

  8. A Generalization of Orthogonal Factorizations in Graphs

    Institute of Scientific and Technical Information of China (English)

    Guo Jun LI; Gui Zhen LIU

    2001-01-01

    Let G be a graph with vertex set V(G) and edge set E(G), and let g and f be two integer-valued functions defined on V(G) such that g(x) ≤ f(x) for all x ∈ V(G). Then a (g, f)-factor of G is a spanning subgraph H of G such that g(x) ≤ dH(x) ≤ f(x) for all x ∈ V(G). A (g, f)-factorization of G G, and H be a subgraph of G with mr edges. If Fi, 1 ≤ i ≤ m, has exactly r edges in common with H,then F is said to be r-orthogonal to H. In this paper it is proved that every (mg + kr, mf - kr)-graph,where m, k and r are positive integers with k < m and g ≥ r, contains a subgraph R such that R has a (g, f)-factorization which is r-orthogonal to a given subgraph H with kr edges.

  9. Generalized L1 penalized matrix factorization

    DEFF Research Database (Denmark)

    Rasmussen, Morten Arendt

    2017-01-01

    for constraining models to obey certain structural properties, including parameter sparsity and sparsity on pairwise differences between parameter estimates. The utility of this framework is used to modify principal component analysis, partial least squares, canonical correlation analysis, and multivariate......Traditionally, chemometric models consists of parameters found by solving a least squares criterion. However, these models can suffer from overfitting, as well as being hard to interpret because of the large number of active parameters. This work proposes the use of a generalized L1 norm penalty...... analysis of variance type of models applied to synthetic and chemical data. This work argues that L1 norm penalized models offers parsimony, robustness and predictive performance, and reveals a path for modifying unconstrained chemometric models through convex penalties....

  10. Fluoroquinolone-Resistant Haemophilus parasuis Isolates Exhibit More Putative Virulence Factors than Their Susceptible Counterparts

    OpenAIRE

    Zhang, Qiang; Liu, Jiantao; Yan, Shuxian; Yang, Yujie; Zhang, Anding; Jin, Meilin

    2013-01-01

    The prevalence of 23 putative virulence factors among fluoroquinolone-susceptible and -resistant Haemophilus parasuis isolates was analyzed. Putative hemolysin precursor, fimbrial assembly chaperone, and type I site-specific restriction modification system R subunit genes were more prevalent among fluoroquinolone-resistant H. parasuis isolates than among fluoroquinolone-susceptible H. parasuis isolates. Fluoroquinolone resistance may be associated with an increase in the presence of some viru...

  11. Generalized Identities Involving Common Factors of Generalized Fibonacci, Jacobsthal and Jacobsthal-Lucas Numbers

    Directory of Open Access Journals (Sweden)

    Yashwant K. Panwar

    2013-08-01

    Full Text Available In this paper, we present generalized identities involving common factors of generalized Fibonacci, Jacobsthal and jacobsthal-Lucas numbers. Binet’s formula will employ to obtain the identities.

  12. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype.

    Science.gov (United States)

    Guiard, Bruno P; David, Denis J P; Deltheil, Thierry; Chenu, Franck; Le Maître, Erwan; Renoir, Thibault; Leroux-Nicollet, Isabelle; Sokoloff, Pierre; Lanfumey, Laurence; Hamon, Michel; Andrews, Anne M; Hen, René; Gardier, Alain M

    2008-02-01

    Growing evidence supports the involvement of brain-derived neurotrophic factor (BDNF) in mood disorders and the mechanism of action of antidepressant drugs. However, the relationship between BDNF and serotonergic signalling is poorly understood. Heterozygous mutants BDNF +/- mice were utilized to investigate the influence of BDNF on the serotonin (5-HT) system and the activity of the serotonin transporter (SERT) in the hippocampus. The zero net flux method of quantitative microdialysis revealed that BDNF +/- heterozygous mice have increased basal extracellular 5-HT levels in the hippocampus and decreased 5-HT reuptake capacity. In keeping with these results, the selective serotonin reuptake inhibitor paroxetine failed to increase hippocampal extracellular 5-HT levels in BDNF +/- mice while it produced robust effects in wild-type littermates. Using in-vitro autoradiography and synaptosome techniques, we investigated the causes of attenuated 5-HT reuptake in BDNF +/- mice. A significant decrease in [3H]citalopram-binding-site density in the CA3 subregion of the ventral hippocampus and a significant reduction in [3H]5-HT uptake in hippocampal synaptosomes, revealed mainly a decrease in SERT function. However, 5-HT1A autoreceptors were not desensitized in BDNF +/- mice. These results provide evidence that constitutive reductions in BDNF modulate SERT function reuptake in the hippocampus.

  13. Are "g" and the General Factor of Personality (GFP) Correlated?

    Science.gov (United States)

    Irwing, Paul; Booth, Tom; Nyborg, Helmuth; Rushton, J. Philippe

    2012-01-01

    We examined whether the General Factor of Personality (GFP) is related to the "g" factor of cognitive ability using data from the Vietnam Experience Study which randomly sampled 4462 Vietnam War veterans from a total sample of about five million Vietnam era army veterans. Exclusionary criteria included passing a fitness test, achieving a…

  14. Zebrafish enpp1 mutants exhibit pathological mineralization, mimicking features of generalized arterial calcification of infancy (GACI and pseudoxanthoma elasticum (PXE

    Directory of Open Access Journals (Sweden)

    Alexander Apschner

    2014-07-01

    Full Text Available In recent years it has become clear that, mechanistically, biomineralization is a process that has to be actively inhibited as a default state. This inhibition must be released in a rigidly controlled manner in order for mineralization to occur in skeletal elements and teeth. A central aspect of this concept is the tightly controlled balance between phosphate, a constituent of the biomineral hydroxyapatite, and pyrophosphate, a physiochemical inhibitor of mineralization. Here, we provide a detailed analysis of a zebrafish mutant, dragonfish (dgf, which is mutant for ectonucleoside pyrophosphatase/phosphodiesterase 1 (Enpp1, a protein that is crucial for supplying extracellular pyrophosphate. Generalized arterial calcification of infancy (GACI is a fatal human disease, and the majority of cases are thought to be caused by mutations in ENPP1. Furthermore, some cases of pseudoxanthoma elasticum (PXE have recently been linked to ENPP1. Similar to humans, we show here that zebrafish enpp1 mutants can develop ectopic calcifications in a variety of soft tissues – most notably in the skin, cartilage elements, the heart, intracranial space and the notochord sheet. Using transgenic reporter lines, we demonstrate that ectopic mineralizations in these tissues occur independently of the expression of typical osteoblast or cartilage markers. Intriguingly, we detect cells expressing the osteoclast markers Trap and CathepsinK at sites of ectopic calcification at time points when osteoclasts are not yet present in wild-type siblings. Treatment with the bisphosphonate etidronate rescues aspects of the dgf phenotype, and we detected deregulated expression of genes that are involved in phosphate homeostasis and mineralization, such as fgf23, npt2a, entpd5 and spp1 (also known as osteopontin. Employing a UAS-GalFF approach, we show that forced expression of enpp1 in blood vessels or the floorplate of mutant embryos is sufficient to rescue the notochord

  15. Cuestionario general de salud-12: análisis de factores en población general de Bucaramanga, Colombia General health questionnaire-12: factor analysis in the general population of Bucaramanga, Colombia

    Directory of Open Access Journals (Sweden)

    Adalberto Campo Arias

    2007-03-01

    binary scoring (0-0-0-1, 0-0-1-1, and 0-1-1-1. RESULTS: The ordinal scoring GHQ-12 presented an internal consistency of 0.779 and two factors that accounted for 42.5% of the variance. In other hand, the scoring way 0-1-1-1 exhibited an internal consistency of 0.774; 0-0-1-1 scoring, of 0.708; 0-0-0-1 scoring, of 0.360. The binary scoring 0-1-1-1 and 0-0-1-1 showed three factors responsible of 50.6% and 46.3% of the variance respectively. The 0-0-0-1 scoring did not present a good factor solution. CONCLUSIONS: Among people from the general populalation the ordinal scoring for the GHQ-12 exhibites better psychometric properties than binary ones. Except the 0-0-0-1 scoring method, reminding scorings present a high internal consistency and aceptable factor solution.

  16. Risk factors for postoperative complications in robotic general surgery.

    Science.gov (United States)

    Fantola, Giovanni; Brunaud, Laurent; Nguyen-Thi, Phi-Linh; Germain, Adeline; Ayav, Ahmet; Bresler, Laurent

    2017-03-01

    The feasibility and safety of robotically assisted procedures in general surgery have been reported from various groups worldwide. Because postoperative complications may lead to longer hospital stays and higher costs overall, analysis of risk factors for postoperative surgical complications in this subset of patients is clinically relevant. The goal of this study was to identify risk factors for postoperative morbidity after robotic surgical procedures in general surgery. We performed an observational monocentric retrospective study. All consecutive robotic surgical procedures from November 2001 to December 2013 were included. One thousand consecutive general surgery patients met the inclusion criteria. The mean overall postoperative morbidity and major postoperative morbidity (Clavien >III) rates were 20.4 and 6 %, respectively. This included a conversion rate of 4.4 %, reoperation rate of 4.5 %, and mortality rate of 0.2 %. Multivariate analysis showed that ASA score >3 [OR 1.7; 95 % CI (1.2-2.4)], hematocrit value surgery [OR 1.5; 95 % CI (1-2)], advanced dissection [OR 5.8; 95 % CI (3.1-10.6)], and multiquadrant surgery [OR 2.5; 95 % CI (1.7-3.8)] remained independent risk factors for overall postoperative morbidity. It also showed that advanced dissection [OR 4.4; 95 % CI (1.9-9.6)] and multiquadrant surgery [OR 4.4; 95 % CI (2.3-8.5)] remained independent risk factors for major postoperative morbidity (Clavien >III). This study identifies independent risk factors for postoperative overall and major morbidity in robotic general surgery. Because these factors independently impacted postoperative complications, we believe they could be taken into account in future studies comparing conventional versus robot-assisted laparoscopic procedures in general surgery.

  17. Obesity - a risk factor for postoperative complications in general surgery?

    NARCIS (Netherlands)

    E.K.M. Tjeertes (Elke); S.S.E. Hoeks (Sanne S.E.); S.S.B.J.C. Beks (Sabine S.B.J.C.); T.M. Valentijn (Tabita); A.A.G.M. Hoofwijk (Anton A.G.M.); R.J. Stolker (Robert J.)

    2015-01-01

    textabstractBackground: Obesity is generally believed to be a risk factor for the development of postoperative complications. Although being obese is associated with medical hazards, recent literature shows no convincing data to support this assumption. Moreover a paradox between body mass index and

  18. Factors Affecting the Relative Efficiency of General Acid Catalysis

    Science.gov (United States)

    Kwan, Eugene E.

    2005-01-01

    A simple framework for evaluating experimental kinetic data to provide support for Specific Acid Catalysis (SAC) and General Acid Catalysis (GAC) is described based on the factors affecting their relative efficiency. Observations reveal that increasing the SAC-to-GAC rate constant ratio reduces the effective pH range for GAC.

  19. Cosmological General Relativity With Scale Factor and Dark Energy

    CERN Document Server

    Oliveira, Firmin J

    2014-01-01

    In this paper the four-dimensional space-velocity Cosmological General Relativity of Carmeli is developed by a general solution to the Einstein field equations. The metric is given in the Tolman form and the vacuum mass density is included in the energy-momentum tensor. The scale factor redshift equation is obtained, forming the basis for deriving the various redshift-distance relations of cosmological analysis. A linear equation of state dependent on the scale factor is assumed to account for the effects of an evolving dark energy in the expansion of the universe. Modeling simulations are provided for a few combinations of mass density, vacuum density and state parameter values over a sample of high redshift SNe Ia data. Also, the Carmeli cosmological model is derived as a special case of the general solution.

  20. General factorization scheme with application to relativistic Hermite polynomials

    CERN Document Server

    Rosu, H C; Obregón, O; Reyes, Marco A; Obregon, Octavio

    1995-01-01

    We present a sufficiently general factorization scheme of second-order linear differential equations having discrete (polynomial) indeces both in the coefficient of the first-derivative term and of the derivative-free one. We apply it to the relativistic Hermite equation in order to perform the factorization with respect to the polynomial degree confirming the factorization of Aldaya, Bisquert and Navarro-Salas, but also obtaining another slightly modified factorization, and to the Gegenbauer equation for the factorization with respect to the order. Moreover, by making use of Nagel's relation between Gegenbauer and relativistic Hermite polynomials we write down ladder-like operations with respect to the order for the latter ones, which are another interesting result of the paper.

  1. Adults with mild to moderate depression exhibit more alcohol related problems compared to the general adult population: a cross sectional study.

    Science.gov (United States)

    Åhlin, Julia; Hallgren, Mats; Öjehagen, Agneta; Källmén, Håkan; Forsell, Yvonne

    2015-06-09

    Alcohol use has been shown to interfere with treatment for depression, but consumption habits are not routinely screened in primary care. To date, few studies have compared the alcohol consumption habits of patients with depression to the general population. The purpose of this study was to compare alcohol habits in adults diagnosed with depression in primary care to the general adult population in Sweden. Nine hundred fourty six patients diagnosed with mild to moderate depression, without a primary substance use disorder, in primary care settings located across Sweden completed the Alcohol Use Disorders Identification Test (AUDIT). Consumptions habits and alcohol related problems in the depressed sample were compared to those in the general adult population (n = 663). Analyses were stratified by gender and age. Ratings of alcohol problems and measures of hazardous drinking and binge drinking were significantly higher among patients seeking treatment for depression in primary care compared to the general population. Male patients scored higher on the AUDIT total and AUDIT-C (consumption) subscale than men in the general population. Compared to younger adults (aged 17-27) older depressed adults (aged 28-50 and 51-71) exhibited higher rates of consumption and problems related to alcohol. Compared to the general adult population, consumption and problems related to alcohol use were substantially higher among patients with mild to moderate depression in primary care. Routine screening of alcohol use in primary care is recommended for patients presenting with depression.

  2. The Development of the General Factor of Psychopathology 'p Factor' Through Childhood and Adolescence.

    Science.gov (United States)

    Murray, Aja Louise; Eisner, Manuel; Ribeaud, Denis

    2016-11-01

    Recent studies have suggested that the structure of psychopathology may be usefully represented in terms of a general factor of psychopathology (p-factor) capturing variance common to a broad range of symptoms transcending diagnostic domains in addition to specific factors capturing variance common to smaller subsets of more closely related symptoms. Little is known about how the general co-morbidity captured by this p-factor develops and whether general co-morbidity increases or decreases over childhood and adolescence. We evaluated two competing hypotheses: 1) dynamic mutualism which predicts growth in general co-morbidity and associated p-factor strength over time and 2) p-differentiation which predicts that manifestations of liabilities towards psychopathology become increasingly specific over time. Data came from the Zurich Project on the Social Development of Children and Youths (z-proso), a longitudinal study of a normative sample (approx. 50 % male) measured at 8 time points from ages 7 to 15. We operationalised general co-morbidity as p-factor strength in a bi-factor model and used omega hierarchical to track how this changed over development. In contrast to the predictions of both dynamic mutualism and p-differentiation, p-factor strength remained relatively constant over the studied period suggesting that such processes do not govern the interplay between psychopathological symptoms during this phase of development. Future research should focus on earlier phases of development and on factors that maintain the consistency of symptom-general covariation across this period.

  3. General surgery in crisis – factors that impact on a career in general ...

    African Journals Online (AJOL)

    In May 2004 ASSA took a decision to initiate a study to determine ... general surgeons chose medicine as a career option, why they decided ... the responsibility of specialists and registrars in training in ... study into the various factors that may influence the choice .... medicine' with the primary objective of making affordable.

  4. Human Exhibitions

    DEFF Research Database (Denmark)

    Andreassen, Rikke

    From 1870s to 1910s, more than 50 exhibitions of so-called exotic people took place in Denmark. Here large numbers of people of Asian and African origin were exhibited for the entertainment and ‘education’ of a mass audience. Several of these exhibitions took place in Copenhagen Zoo. Here different...... light on the staging of exhibitions, the daily life of the exhibitees, the wider connections between shows across Europe and the thinking of the time on matters of race, science, gender and sexuality. A window onto contemporary racial understandings, the book presents interviews with the descendants...... of displayed people, connecting the attitudes and science of the past with both our (continued) modern fascination with ‘the exotic’, and contemporary language and popular culture. As such, it will be of interest to scholars of sociology, anthropology and history working in the areas of gender and sexuality...

  5. Awareness with recall during general anesthesia: incidence and risk factors.

    Science.gov (United States)

    Ranta, S O; Laurila, R; Saario, J; Ali-Melkkilä, T; Hynynen, M

    1998-05-01

    We studied the associated factors and incidence of awareness during general anesthesia and the nature of subsequent psychiatric disorders. Patients older than 12 yr undergoing surgery under general anesthesia in a secondary care hospital during 1 yr were included in the study. The doses of anesthetics were calculated for the patients with and without awareness. There were 4818 operations under general anesthesia; 2612 (54%) patients were interviewed. Ten (0.4% of those interviewed) patients were found to have undisputed awareness, and there were nine (0.3%) patients with possible awareness. The doses of isoflurane (P awareness. Five patients with awareness underwent a psychiatric evaluation. One patient experienced sleep disturbances afterward, but the other four patients did not have any after effects. In conclusion, awareness is a rare complication of general anesthesia associated with small doses of anesthetics. In an interview of 2612 patients after general anesthesia, 10 (0.4%) patients with awareness and 9 (0.3%) patients with possible awareness were found. A predisposing factor was small doses of the principal anesthetic. In a psychiatric interview, a large proportion of the patients with awareness were found to have suffered from depression in the past.

  6. Thoughts of Quitting General Surgery Residency: Factors in Canada.

    Science.gov (United States)

    Ginther, David Nathan; Dattani, Sheev; Miller, Sarah; Hayes, Paul

    2016-01-01

    Attrition rates in general surgery training are higher than other surgical disciplines. We sought to determine the prevalence with which Canadian general surgery residents consider leaving their training and the contributing factors. An anonymous survey was administered to all general surgery residents in Canada. Responses from residents who considered leaving their training were assessed for importance of contributing factors. The study was conducted at the Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada, a tertiary academic center. The response rate was approximately 34.0%. A minority (32.0%) reported very seriously or somewhat seriously considering leaving their training, whereas 35.2% casually considered doing so. Poor work-life balance in residency (38.9%) was the single-most important factor, whereas concern about future unemployment (16.7%) and poor future quality of life (15.7%) were next. Enjoyment of work (41.7%) was the most frequent mitigating factor. Harassment and intimidation were reported factors in 16.7%. On analysis, only intention to practice in a nonacademic setting approached significant association with thoughts of leaving (odds ratio = 1.92, CI = 0.99-3.74, p = 0.052). There was no association with sex, program, postgraduate year, relationship status, or subspecialty interest. There was a nonsignificant trend toward more thoughts of leaving with older age. Canadian general surgery residents appear less likely to seriously consider quitting than their American counterparts. Poor work-life balance in residency, fear of future unemployment, and anticipated poor future quality of life are significant contributors to thoughts of quitting. Efforts to educate prospective residents about the reality of the surgical lifestyle, and to assist residents in securing employment, may improve completion rates. Copyright © 2016 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  7. Cherenkov loss factor of short relativistic bunches:general approach

    CERN Document Server

    Baturin, S S

    2013-01-01

    The interaction of short relativistic charged particle bunches with waveguides and other accelerator system components is a critical issue for the development of X-ray FELs (free electron lasers) and linear collider projects. Wakefield Cherenkov losses of short bunches have been studied previously for resistive wall, disk-loaded, corrugated and dielectric loaded waveguides. It was noted in various publications [1] that if the slowdown layer is thin, the Cherenkov loss factor of a short bunch does not depend on the guiding system material and is a constant for any given transverse cross section dimensions of the waveguides. In this paper, we consider a new approach to the analysis of loss factors for relativistic short bunches and formulate a general integral relation that allows calculation of the loss factor for a short relativistic bunch passing an arbitrary waveguide system. The loss factors calculated by this new method for various types of waveguides with arbitrary thickness slowdown layers, including in...

  8. Candida species from oral cavity of HIV-infected children exhibit reduced virulence factors in the HAART era.

    Science.gov (United States)

    Portela, Maristela Barbosa; Lima de Amorim, Elaine; Santos, Adrielle Mangabeira; Alexandre da Rocha Curvelo, José; de Oliveira Martins, Karol; Capillé, Cauli Lima; Maria de Araújo Soares, Rosangela; Barbosa de Araújo Castro, Gloria Fernanda

    2017-01-01

    This study aimed to assess, in vitro, the biofilm viability and the phospholipase and protease production of Candida spp. from the saliva of HIV infected children and healthy controls, and to correlate the results with the use of medical data. A total of 79 isolates were analyzed: 48 Candida albicans isolates (33/15) and 20 Candida parapsilosis sensu lato complex isolates (12/8) (from HIV/control patients, respectively), and 8 Candida krusei, 1 Candida tropicalis, 1 Candida dubliniensis and 1 Candida guilliermondii from HIV patients. The XTT (2, 3-bis (2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-Carboxanilide) reduction assay analyzed the biofilm viability. Phospholipase and protease assays were performed using the egg yolk and Bovine Serum Albumin agar plate methods, respectively. All isolates were able to form biofilm with cell viability. Quantitatively, Candida isolates from both groups presented a similar ability to form biofilm (p > 0.05). The biofilm viability activity was higher in C. albicans isolates than in non-albicans Candida isolates (p Candida spp. isolates from HIV-positive children presented higher phospholipase production, in vitro they exhibited reduced virulence factors compared to isolates from healthy individuals. This finding may enlighten the role played by immunosuppression in the modulation of Candida virulence attributes. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Factor structure of the 12-item General Health Questionnaire in the Japanese general adult population.

    Science.gov (United States)

    Doi, Yuriko; Minowa, Masumi

    2003-08-01

    The 12-item General Health Questionnaire (GHQ-12) has been extensively used in a variety of settings across countries. The main aim of the present study was to assess the factor structure of the GHQ-12 for the Japanese general adult population. Data came from a sample of 1808 Japanese aged 20 years or older who were randomly selected based on the 1995 census (897 men and 911 women). Cronbach's alpha coefficients were 0.83 for men and 0.85 for women. Overall, the corrected item-total correlation coefficients were >0.20 for both genders. The GHQ-12 yielded a two-factor solution of psychological distress (items 2, 5, 6, 9, 10 and 11) and social dysfunction (items 1, 3, 4, 7 and 8), which jointly accounted for 49.1% of the total variance, for women. Item 12 on happiness was not discernable. For men, item 12 was separated from a social dysfunction factor and yielded the third factor with item 3 on social role, and the three factors jointly accounted for 57.6%. The results of the present study suggest that the GHQ-12 can be used as an internally reliable and homogeneous scale that produces mainly the factors of psychological distress and social dysfunction. Item 12 may be structurally different in the case of Japanese adults.

  10. Exhibit Engineering

    DEFF Research Database (Denmark)

    Mortensen, Marianne Foss

    of tools and processes to guide the design of educational science exhibits. The guiding paradigm for this development is design-based research, which is characterised by an iterative cycle of design, enactment, and analysis. In the design phase, an educational intervention is planned and carried out based...... on a hypothesised learning process and the means of supporting it. In the enactment phase, the educational intervention is implemented (i.e. the planned lesson is taught, or the museum exhibit is opened to the public). Finally, the analysis phase establishes causality between emergent characteristics...... of the learning outcomes and the design characteristics of the intervention. The analysis process can yield two types of outcomes: Suggestions for the refinement of the specific design in question, and “humble” theory, which is theory that can guide the design of a category of educational interventions...

  11. Expression of fibroblast growth factor-2 and fibroblast growth factor receptor-1 protein in the hippocampus in rats exhibiting chronic stress-induced depression

    Institute of Scientific and Technical Information of China (English)

    Gonglin Hou; Mingming Tang

    2011-01-01

    There is evidence that the expression of members of the fibroblast growth factor (FGF) protein family is altered in post-mortem brains of humans suffering from major depressive disorder. The present study examined whether the expression of fibroblast growth factor-2 (FGF2) and fibroblast growth factor receptor-1 (FGFR1) protein is altered following chronic stress in an animal model. Rats were exposed to 35 days of chronic unpredictable mild stress, and then tested using open-field and sucrose consumption tests. Compared with the control group, rats in the chronic stress group exhibited obvious depressive-like behaviors, including anhedonia, anxiety and decreased mobility. The results of western blot analysis and immunohistochemical analysis revealed a downregulation of the expression of FGF2 and FGFR1 in the hippocampus of rats, particularly in the CA1, CA3 and dentate gyrus. This decreased expression is in accord with the results of post-mortem studies in humans with major depressive disorder. These findings suggest that FGF2 and FGFR1 proteins participate in the pathophysiology of depressive-like behavior, and may play an important role in the mechanism of chronic stress-induced depression.

  12. Model reductions for inference: generality of pairwise, binary, and planar factor graphs.

    Science.gov (United States)

    Eaton, Frederik; Ghahramani, Zoubin

    2013-05-01

    We offer a solution to the problem of efficiently translating algorithms between different types of discrete statistical model. We investigate the expressive power of three classes of model-those with binary variables, with pairwise factors, and with planar topology-as well as their four intersections. We formalize a notion of "simple reduction" for the problem of inferring marginal probabilities and consider whether it is possible to "simply reduce" marginal inference from general discrete factor graphs to factor graphs in each of these seven subclasses. We characterize the reducibility of each class, showing in particular that the class of binary pairwise factor graphs is able to simply reduce only positive models. We also exhibit a continuous "spectral reduction" based on polynomial interpolation, which overcomes this limitation. Experiments assess the performance of standard approximate inference algorithms on the outputs of our reductions.

  13. Nucleon form factors, generalized parton distributions and quark angular momentum

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, Markus [Deutsches Elektronen-Synchrotron (DESY), Hamburg (Germany); Kroll, Peter [Bergische Univ., Wuppertal (Germany). Fachbereich Physik; Regensburg Univ. (Germany). Institut fuer Theoretische Physik

    2013-02-15

    We extract the individual contributions from u and d quarks to the Dirac and Pauli form factors of the proton, after a critical examination of the available measurements of electromagnetic nucleon form factors. From this data we determine generalized parton distributions for valence quarks, assuming a particular form for their functional dependence. The result allows us to study various aspects of nucleon structure in the valence region. In particular, we evaluate Ji's sum rule and estimate the total angular momentum carried by valence quarks at the scale {mu}=2 GeV to be J{sup u}{sub v}=0.230{sup +0.009}{sub -0.024} and J{sup d}{sub v}=-0.004{sup +0.010}{sub -0.016}.

  14. The Factors Affecting Performance of Nurse at Paniai General Hospital

    Directory of Open Access Journals (Sweden)

    Elias Tatogo

    2017-02-01

    Full Text Available General hospital of Paniai regency health service institution under Local Government Paniai Regency with amount of nurse resource counted 69 one who have duty to remain to can improve more certifiable service and reached by society, so to be form degree of health which at the farthest, so that nurse performance of vital importance in giving of health service. The goal of research: To knowing of factors affecting performance of nurse at Paniai general hospital. Method: Type research is causal associative by using quantitative approach. Sample is all of nurse as much 69 nurse with date implemented in October 2016. Data obtained used questioner and analyzed by chi square test. Result of research is obtained that factor’s affecting of nurse performance in Paniai General Hospital is motivation (p-value = 0,001; RP = 3,000; CI95%= 1,607 - 5,601, [job/activity] discipline (p-value = 0,043; RP = 2,068; CI95%= 1,150 - 3,719, reward (p- value = 0,001; RP = 5,008; CI95%= 1,656 - 15,142, punishment (p- value = 0,000 ; RP= 16,839; CI95%= ( 4,310 - 65,784 and style leadership [of] director (p- value = 0,000; RP = 3,333; CI95%= 1,742 - 6,380. The factor’s not related of nurse performance at Paniai general hospital is age (p- value = 1,000 ; RP = 0,908; CI95%= 0,456 - 1,806, long working (p- value = 1,000; RP = 0,908; CI95%= 0,456 - 1,806 and job rotation (p- value = 0,843; RP = 1,190; CI95%= 0,603 – 2,348.

  15. Computing generalized inverses using LU factorization of matrix product

    CERN Document Server

    Stanimirović,; Tasić,; B, M; 10.1080/00207160701582077

    2011-01-01

    An algorithm for computing {2, 3}, {2, 4}, {1, 2, 3}, {1, 2, 4} -inverses and the Moore-Penrose inverse of a given rational matrix A is established. Classes A(2, 3)s and A(2, 4)s are characterized in terms of matrix products (R*A)+R* and T*(AT*)+, where R and T are rational matrices with appropriate dimensions and corresponding rank. The proposed algorithm is based on these general representations and the Cholesky factorization of symmetric positive matrices. The algorithm is implemented in programming languages MATHEMATICA and DELPHI, and illustrated via examples. Numerical results of the algorithm, corresponding to the Moore-Penrose inverse, are compared with corresponding results obtained by several known methods for computing the Moore-Penrose inverse.

  16. Conformal anomaly of generalized form factors and finite loop integrals

    CERN Document Server

    Chicherin, Dmitry

    2017-01-01

    We reveal a new mechanism of conformal symmetry breaking at Born level. It occurs in generalized form factors with several local operators and an on-shell state of massless particles. The effect is due to hidden singularities on collinear configurations of the momenta. This conformal anomaly is different from the holomorphic anomaly of amplitudes. We present a number of examples in four and six dimensions. We find an application of the new conformal anomaly to finite loop momentum integrals with one or more massless legs. The collinear region around a massless leg creates a contact anomaly, made visible by the loop integration. The anomalous conformal Ward identity for an $\\ell-$loop integral is a 2nd-order differential equation whose right-hand side is an $(\\ell-1)-$loop integral. We show several examples, in particular the four-dimensional scalar double box.

  17. General Adjustment Influence Factor of Malaysian Construction Expatriates Executives Abroad

    Directory of Open Access Journals (Sweden)

    Zainol Halmi

    2016-01-01

    Full Text Available The success of Malaysian construction companies creates an opportunity to explore abroad. Past studies have shown that the difficulty of expatriates in adjusting to a new environment is the main aspect that leads to failure of assignments. The success in implementing an overseas assignment does not solely depend on an expatriate’s technical expertise. The adjustment issues such as the interaction with the host nationals, and adaptability to the host country’s culture also exert influence on the assignment. The research was conducted to identify the influence of executive expatriate general adjustment on assignment in host countries. The objective of the study was to identify adjustment influence factors relating to general adjustment abroad. Questionnaires were sent to Malaysian expatriate executives. Sixty four Malaysian expatriate executives from Malaysian construction companies overseas were involved in this study. The findings show interaction, social and living environment influences their adjustment during expatriation. Pre-departure training preparation aspects for expatriates is a good step before their departure to host countries.

  18. The Generalized Conversion Factor in Einstein's Mass-Energy Equation

    Directory of Open Access Journals (Sweden)

    Sharma A.

    2008-07-01

    Full Text Available Einstein’s September 1905 paper is origin of light energy-mass inter conversion equa- tion ( L = mc 2 and Einstein speculated E = mc 2 from it by simply replacing L by E . From its critical analysis it follows that L = mc 2 is only true under special or ideal conditions. Under general cases the result is L / mc 2 ( E / mc 2 . Conse- quently an alternate equation E = Ac 2 M has been suggested, which implies that energy emitted on annihilation of mass can be equal, less and more than predicted by E = mc 2 . The total kinetic energy of fission fragments of U 235 or Pu 239 is found experimentally 20–60 MeV less than Q -value predicted by mc 2 . The mass of parti- cle Ds (2317 discovered at SLAC, is more than current estimates. In many reactions including chemical reactions E = mc 2 is not confirmed yet, but regarded as true. It implies the conversion factor than c 2 is possible. These phenomena can be explained with help of generalized mass-energy equation E = Ac 2 M .

  19. The Generalized Conversion Factor in Einstein's Mass-Energy Equation

    Directory of Open Access Journals (Sweden)

    Ajay Sharma

    2008-07-01

    Full Text Available Einstein's September 1905 paper is origin of light energy-mass inter conversion equation ($L = Delta mc^{2}$ and Einstein speculated $E = Delta mc^{2}$ from it by simply replacing $L$ by $E$. From its critical analysis it follows that $L = Delta mc^{2}$ is only true under special or ideal conditions. Under general cases the result is $L propto Delta mc^{2}$ ($E propto Delta mc^{2}$. Consequently an alternate equation $Delta E = A ub c^{2}Delta M$ has been suggested, which implies that energy emitted on annihilation of mass can be equal, less and more than predicted by $Delta E = Delta mc^{2}$. The total kinetic energy of fission fragments of U-235 or Pu-239 is found experimentally 20-60 MeV less than Q-value predicted by $Delta mc^{2}$. The mass of particle Ds (2317 discovered at SLAC, is more than current estimates. In many reactions including chemical reactions $E = Delta mc^{2}$ is not confirmed yet, but regarded as true. It implies the conversion factor than $c^{2}$ is possible. These phenomena can be explained with help of generalized mass-energy equation $Delta E = A ub c^{2}Delta M$.

  20. Nightmares: risk factors among the Finnish general adult population.

    Science.gov (United States)

    Sandman, Nils; Valli, Katja; Kronholm, Erkki; Revonsuo, Antti; Laatikainen, Tiina; Paunio, Tiina

    2015-04-01

    To identify risk factors for experiencing nightmares among the Finnish general adult population. The study aimed to both test whether previously reported correlates of frequent nightmares could be reproduced in a large population sample and to explore previously unreported associations. Two independent cross-sectional population surveys of the National FINRISK Study. Age- and sex-stratified random samples of the Finnish population in 2007 and 2012. A total of 13,922 participants (6,515 men and 7,407 women) aged 25-74 y. N/A. Nightmare frequency as well as several items related to socioeconomic status, sleep, mental well-being, life satisfaction, alcohol use, medication, and physical well-being were recorded with a questionnaire. In multinomial logistic regression analysis, a depression-related negative attitude toward the self (odds ratio [OR] 1.32 per 1-point increase), insomnia (OR 6.90), and exhaustion and fatigue (OR 6.86) were the strongest risk factors for experiencing frequent nightmares (P < 0.001 for all). Sex, age, a self-reported impaired ability to work, low life satisfaction, the use of antidepressants or hypnotics, and frequent heavy use of alcohol were also strongly associated with frequent nightmares (P < 0.001 for all). Symptoms of depression and insomnia were the strongest predictors of frequent nightmares in this dataset. Additionally, a wide variety of factors related to psychological and physical well-being were associated with nightmare frequency with modest effect sizes. Hence, nightmare frequency appears to have a strong connection with sleep and mood problems, but is also associated with a variety of measures of psychological and physical well-being. © 2015 Associated Professional Sleep Societies, LLC.

  1. Tumors initiated by constitutive Cdk2 activation exhibit transforming growth factor beta resistance and acquire paracrine mitogenic stimulation during progression

    DEFF Research Database (Denmark)

    Corsino, P.; Davis, B.; Law, M.;

    2007-01-01

    mediate some of the transforming effects that result from cyclin D1 overexpression in human breast cancers. MMTV-DIK2 cancer cells express the hepatocyte growth factor (HGF) receptor, c-Met. MMTV-D1K2 cancer cells also secrete transforming growth factor beta (TGF beta), but are relatively resistant to TGF......Cyclin D1/cyclin-dependent kinase 2 (Cdk2) complexes are present at high frequency in human breast cancer cell lines, but the significance of this observation is unknown. This report shows that expression of a cyclin D1-Cdk2 fusion protein under the control of the mouse mammary tumor virus (MMITV...... beta antiproliferative effects. Fibroblasts derived from MMTV-DIK2 tumors secrete factors that stimulate the proliferation of MMTV-D1K2 cancer cells, stimulate c-Met tyrosine phosphorylation, and stimulate the phosphorylation of the downstream signaling intermediates p70(s6k) and Akt on activating...

  2. A Health Education Program for Parents and Children Who Exhibit High Risk Factors of Coronary Heart Disease.

    Science.gov (United States)

    Hopp, Joyce W.; And Others

    This study demonstrated the feasibility of joint parent-child education to change the behaviors known to be associated with increased risk of coronary heart disease. Earlier studies have shown that parents who are at increased risk of coronary heart disease can be identified by studying certain factors in the children. Utilizing a combined risk…

  3. Generating functions for Wilf equivalence under generalized factor order

    CERN Document Server

    Langley, Thomas; Remmel, Jeffrey

    2010-01-01

    Kitaev, Liese, Remmel, and Sagan recently defined generalized factor order on words comprised of letters from a partially ordered set $(P, \\leq_P)$ by setting $u \\leq_P w$ if there is a subword $v$ of $w$ of the same length as $u$ such that the $i$-th character of $v$ is greater than or equal to the $i$-th character of $u$ for all $i$. This subword $v$ is called an embedding of $u$ into $w$. For the case where $P$ is the positive integers with the usual ordering, they defined the weight of a word $w = w_1\\ldots w_n$ to be $\\text{wt}(w) = x^{\\sum_{i=1}^n w_i} t^{n}$, and the corresponding weight generating function $F(u;t,x) = \\sum_{w \\geq_P u} \\text{wt}(w)$. They then defined two words $u$ and $v$ to be Wilf equivalent, denoted $u \\backsim v$, if and only if $F(u;t,x) = F(v;t,x)$. They also defined the related generating function $S(u;t,x) = \\sum_{w \\in \\mathcal{S}(u)} \\text{wt}(w)$ where $\\mathcal{S}(u)$ is the set of all words $w$ such that the only embedding of $u$ into $w$ is a suffix of $w$, and showed t...

  4. 2 October 2013 - Israel Ambassador to the United Nations Office and other International Organizations at Geneva E. Manor on the occasion of the inauguration of the "Israel at CERN" Industrial Exhibition with CERN Director-General R. Heuer.

    CERN Multimedia

    Anna Pantelia

    2013-01-01

    2 October 2013 - Israel Ambassador to the United Nations Office and other International Organizations at Geneva E. Manor on the occasion of the inauguration of the "Israel at CERN" Industrial Exhibition with CERN Director-General R. Heuer.

  5. The translation initiation factor 3f (eIF3f exhibits a deubiquitinase activity regulating Notch activation.

    Directory of Open Access Journals (Sweden)

    Julien Moretti

    Full Text Available Activation of the mammalian Notch receptor after ligand binding relies on a succession of events including metalloprotease-cleavage, endocytosis, monoubiquitination, and eventually processing by the gamma-secretase, giving rise to a soluble, transcriptionally active molecule. The Notch1 receptor was proposed to be monoubiquitinated before its gamma-secretase cleavage; the targeted lysine has been localized to its submembrane domain. Investigating how this step might be regulated by a deubiquitinase (DUB activity will provide new insight for understanding Notch receptor activation and downstream signaling. An immunofluorescence-based screening of an shRNA library allowed us to identify eIF3f, previously known as one of the subunits of the translation initiation factor eIF3, as a DUB targeting the activated Notch receptor. We show that eIF3f has an intrinsic DUB activity. Knocking down eIF3f leads to an accumulation of monoubiquitinated forms of activated Notch, an effect counteracted by murine WT eIF3f but not by a catalytically inactive mutant. We also show that eIF3f is recruited to activated Notch on endocytic vesicles by the putative E3 ubiquitin ligase Deltex1, which serves as a bridging factor. Finally, catalytically inactive forms of eIF3f as well as shRNAs targeting eIF3f repress Notch activation in a coculture assay, showing that eIF3f is a new positive regulator of the Notch pathway. Our results support two new and provocative conclusions: (1 The activated form of Notch needs to be deubiquitinated before being processed by the gamma-secretase activity and entering the nucleus, where it fulfills its transcriptional function. (2 The enzyme accounting for this deubiquitinase activity is eIF3f, known so far as a translation initiation factor. These data improve our knowledge of Notch signaling but also open new avenues of research on the Zomes family and the translation initiation factors.

  6. The p Factor: One General Psychopathology Factor in the Structure of Psychiatric Disorders?

    Science.gov (United States)

    Caspi, Avshalom; Houts, Renate M.; Belsky, Daniel W.; Goldman-Mellor, Sidra J.; Harrington, HonaLee; Israel, Salomon; Meier, Madeline H.; Ramrakha, Sandhya; Shalev, Idan; Poulton, Richie; Moffitt, Terrie E.

    2013-01-01

    Mental disorders traditionally have been viewed as distinct, episodic, and categorical conditions. This view has been challenged by evidence that many disorders are sequentially comorbid, recurrent/chronic, and exist on a continuum. Using the Dunedin Multidisciplinary Health and Development Study, we examined the structure of psychopathology, taking into account dimensionality, persistence, co-occurrence, and sequential comorbidity of mental disorders across 20 years, from adolescence to midlife. Psychiatric disorders were initially explained by three higher-order factors (Internalizing, Externalizing, and Thought Disorder) but explained even better with one General Psychopathology dimension. We have called this dimension the p factor because it conceptually parallels a familiar dimension in psychological science: the g factor of general intelligence. Higher p scores are associated with more life impairment, greater familiality, worse developmental histories, and more compromised early-life brain function. The p factor explains why it is challenging to find causes, consequences, biomarkers, and treatments with specificity to individual mental disorders. Transdiagnostic approaches may improve research. PMID:25360393

  7. Corticotropin-Releasing Factor-Overexpressing Mice Exhibit Reduced Neuronal Activation in the Arcuate Nucleus and Food Intake in Response to Fasting

    OpenAIRE

    2008-01-01

    Corticotropin-releasing factor (CRF) overexpressing (OE) mice are a genetic model that exhibits features of chronic stress. We investigated whether the adaptive feeding response to a hypocaloric challenge induced by food deprivation is impaired under conditions of chronic CRF overproduction. Food intake response to a 16-h overnight fast and ip injection of gut hormones regulating food intake were compared in CRF-OE and wild type (WT) littermate mice along with brain Fos expression, circulatin...

  8. Bacillus cereus enterotoxins act as major virulence factors and exhibit distinct cytotoxicity to different human cell lines.

    Science.gov (United States)

    Jeßberger, Nadja; Dietrich, Richard; Bock, Stefanie; Didier, Andrea; Märtlbauer, Erwin

    2014-01-01

    A comparative analysis on the relevance of the Bacillus cereus enterotoxins Nhe (nonhemolytic enterotoxin), HBL (haemolysin BL) and CytK (cytotoxin K) was accomplished, concerning their toxic activity towards different target cell lines. Overall, among the components secreted by the reference strains for Nhe and HBL, the enterotoxin complexes accounted for over 90% of the total toxicity. Vero and primary endothelial cells (HUVEC) were highly susceptible to Nhe, whereas Hep-G2, Vero and A549 reacted most sensitive to Nhe plus HBL. For CytK the highest toxicity was observed on CaCo-2 cells. As HBL positive strains always produce Nhe in parallel, the specific contribution of both enterotoxin complexes to the overall observed cytotoxic effects was determined by consecutively removing their single components. While in most cell lines Nhe and HBL contributed more or less equally (40-60%) to cytotoxicity, the relative activity of Nhe was approximately 90% in HUVEC, and that of HBL 75% in A549 cells. With U937, a nearly Nhe resistant cell line was identified for the first time. This distinct susceptibility of cell lines was confirmed by investigating a set of 37 B. cereus strains. Interestingly, whereas Nhe is the enterotoxin mainly responsible for cell death as determined by WST-1 bioassays, more rapid pore formation was observed when HBL was present, pointing to a different mode of action of the two enterotoxin complexes. Furthermore, correlation was observed between cytotoxicity of solely Nhe producing strains and NheB. Cytotoxicity of Nhe/HBL producing isolates correlated with the expression of HBL L1, NheB and HBL B. In conclusion, the observed susceptibilities of target cell lines of different histological origin underline that B. cereus enterotoxins represent major virulence factors and that toxicity is not restricted to gastrointestinal infections. The varying contribution of Nhe and HBL to total cytotoxicity strongly indicates that Nhe as well as HBL specific B

  9. Pervasiveness of Dominant General Factors in Organizational Measurement

    Science.gov (United States)

    2015-09-01

    james ree et al . any other factor and influences each observed variable. A DGF is different from a group factor (Carroll, 1993; Thurstone , 1938...Applied Psy- chology, 4, 25–29. Thurstone , L. L. (1938). Primary mental abilities. Psychometric Monographs, 1. Chicago, IL: University of Chicago Press

  10. A general psychopathology factor (P factor) in children: Structural model analysis and external validation through familial risk and child global executive function.

    Science.gov (United States)

    Martel, Michelle M; Pan, Pedro M; Hoffmann, Maurício S; Gadelha, Ary; do Rosário, Maria C; Mari, Jair J; Manfro, Gisele G; Miguel, Eurípedes C; Paus, Tomás; Bressan, Rodrigo A; Rohde, Luis A; Salum, Giovanni A

    2017-01-01

    High rates of comorbidities and poor validity of disorder diagnostic criteria for mental disorders hamper advances in mental health research. Recent work has suggested the utility of continuous cross-cutting dimensions, including general psychopathology and specific factors of externalizing and internalizing (e.g., distress and fear) syndromes. The current study evaluated the reliability of competing structural models of psychopathology and examined external validity of the best fitting model on the basis of family risk and child global executive function (EF). A community sample of 8,012 families from Brazil with children ages 6-12 years completed structured interviews about the child and parental psychiatric syndromes, and a subsample of 2,395 children completed tasks assessing EF (i.e., working memory, inhibitory control, and time processing). Confirmatory factor analyses tested a series of structural models of psychopathology in both parents and children. The model with a general psychopathology factor ("P factor") with 3 specific factors (fear, distress, and externalizing) exhibited the best fit. The general P factor accounted for most of the variance in all models, with little residual variance explained by each of the 3 specific factors. In addition, associations between child and parental factors were mainly significant for the P factors and nonsignificant for the specific factors from the respective models. Likewise, the child P factor-but not the specific factors-was significantly associated with global child EF. Overall, our results provide support for a latent overarching P factor characterizing child psychopathology, supported by familial associations and child EF. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  11. Designing a general deep web harvester by harvestability factor

    NARCIS (Netherlands)

    Khelghati, Mohammadreza; Keulen, van Maurice; Hiemstra, Djoerd

    2014-01-01

    To make deep web data accessible, harvesters have a crucial role. Targeting different domains and websites enhances the need of a general-purpose harvester which can be applied to different settings and situations. To develop such a harvester, a large number of issues should be addressed. To have al

  12. Designing A General Deep Web Harvester by Harvestability Factor

    NARCIS (Netherlands)

    Khelghati, Mohammadreza; Hiemstra, Djoerd; van Keulen, Maurice

    2014-01-01

    To make deep web data accessible, harvesters have a crucial role. Targeting different domains and websites enhances the need of a general-purpose harvester which can be applied to different settings and situations. To develop such a harvester, a large number of issues should be addressed. To have

  13. Prognostic Factors in Adults With Knee Pain in General Practice

    NARCIS (Netherlands)

    Belo, J. N.; Berger, M. Y.; Koes, B. W.; Bierma-Zeinstra, S. M. A.

    2009-01-01

    Objective. To predict the 1-year outcome of incident nontraumatic knee symptoms in adults presenting in general practice. Methods. Adults age >35 years with nontraumatic knee symptoms (n = 480) were followed for 1 year. At baseline, data on knee symptoms and demographics were collected and a

  14. Exhibition Highlights Development of Human Rights in China——An interview with Professor Dong Yunhu, vice-president and secretary-general of China Society for Human Rights Studies

    Institute of Scientific and Technical Information of China (English)

    OUR STAFF REPORTER

    2007-01-01

    @@ EDITOR'S NOTE: An exhibition on human rights in China was held in the Cultural Palace of Ethnic Groups, Beijing, November 17-26, 2006,jointly by the Information Office of the State Council, China Society for Human Rights Studies (CSHRS) and China Human Rights Development Fund. The exhibition attracted more than 10,000 visitors from in and outside the country and aroused much media attention. Following is an interview by our reporter with Prof. Dong Yunhu, vice-president and secretary-general of the CSHRS, on the exhibition.

  15. The Factor Structure of ADHD in a General Population of Primary School Children

    Science.gov (United States)

    Ullebo, Anne Karin; Breivik, Kyrre; Gillberg, Christopher; Lundervold, Astri J.; Posserud, Maj-Britt

    2012-01-01

    Objective: To examine whether a bifactor model with a general ADHD factor and domain specific factors of inattention, hyperactivity and impulsivity was supported in a large general population sample of children. We also explored the utility of forming subscales based on the domain-specific factors. Methods: Child mental health questionnaires were…

  16. Generalized beam quality factor of aberrated truncated Gaussian laser beams

    CSIR Research Space (South Africa)

    Mafusire, C

    2011-07-01

    Full Text Available factor of aberrated truncated Gaussian laser beams Cosmas Mafusire1,2 and Andrew Forbes1,2,* 1Council for Scientific and Industrial Research National Laser Centre, P.O. Box 395, Pretoria, South Africa 2School of Physics, University of Kwa... is verified experimentally by implementing aberrations as digital holograms in the laboratory. ? 2011 Optical Society of America OCIS codes: 140.3295, 080.1005, 120.5050. 1. INTRODUCTION The laser beam quality factor (M2) is a useful parameter...

  17. [What factors aid in the recruitment of general practice as a career? An enquiry by interview of general practitioners].

    Science.gov (United States)

    Natanzon, Iris; Ose, D; Szecsenyi, J; Joos, S

    2010-05-01

    In some parts of Germany there is already a lack of general practitioners (GPs). The reasons for this lack are complex. On the one hand there is an increasing demand for GPs as a result to demographic changes and an increase in the number of chronic diseases. On the other hand fewer medical students decide to become a general practitioner. The aim of this study was to explore, from the perspective of GPs, factors influencing the choice of general practice as a career. Also analysed is the extent to which those factors influence medical students in their carrier choice. 16 GPs were interviewed. Qualitative content analysis according to Mayring has been assisted by the Atlas.ti software program. GPs thought that the occupational orientation of medical students would be strongly dependent on the attractiveness of their future profession. Factors affecting the day-to-day work of general practice and may deterring the carrier choice of students were: poor working and general conditions leading to an increasing dissatisfaction among GPs; decreasing prestige of GPs caused by changed personal and occupational values and attitudes within the society; as well as poor representation and image of general practice as a discipline within the medical curriculum. Various approaches aimed at different target groups can be derived from these identified factors: the government providing general and occupational conditions that would relieve GPs of excessive bureaucracy; universities and medical associations meeting the challenge by improving undergraduate and postgraduate education in general practice; and GPs themselves giving a more self-confident presentation of general practice. Georg Thieme Verlag KG Stuttgart * New York.

  18. Dual blockade of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (FGF-2) exhibits potent anti-angiogenic effects.

    Science.gov (United States)

    Li, Dong; Xie, Kun; Zhang, Longzhen; Yao, Xuejing; Li, Hongwen; Xu, Qiaoyu; Wang, Xin; Jiang, Jing; Fang, Jianmin

    2016-07-28

    Both vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF or FGF-2) are potent pro-angiogenic factors and play a critical role in cancer development and progression. Clinical anti-VEGF therapy trials had a major challenge due to upregulated expression of other pro-angiogenic factor, like FGF-2. This study developed a novel chimeric decoy receptor VF-Trap fusion protein to simultaneously block activity of both VEGF and FGF pathways in order to achieve an additive or synergistic anti-tumor effect. Our in vitro data showed that VF-Trap potently blocked proliferation and migration of both VEGF- and FGF-2-induced vascular endothelial cells. In animal models, treatment of xenograft tumors with VF-Trap resulted in significant inhibition of tumor growth compared to blockage of the single molecule, like VEGF or FGF blocker. In addition, VF-Trap was also more potent in inhibition of ocular angiogenesis in a mouse oxygen-induced retinopathy (OIR) model. These data demonstrated the potent anti-angiogenic effects of this novel VF-Trap fusion protein on blockage of VEGF and FGF-2 activity in vitro and in animal models. Further study will assess its effects in clinic as a therapeutic agent for angiogenesis-related disorders, such as cancer and ocular vascular diseases.

  19. Risk factors for potential drug interactions in general practice

    DEFF Research Database (Denmark)

    Bjerrum, Lars; Gonzalez Lopez-Valcarcel, Beatriz; Petersen, Gert

    2008-01-01

    Pharmacoepidemiologic Database, OPED) covering prescriptions to all inhabitants in the county of Funen, Denmark. All individuals exposed to concurrent use of two or more drugs (polypharmacy) were identified. Combinations of drugs with potential interactions were registered and classified as major, moderate, or minor......, depending on the severity of outcome and the quality of documentation. A two-level random coefficient logistic regression model was used to investigate factors related to potential drug interactions. Results: One-third of the population was exposed to polypharmacy, and 6% were exposed to potential drug...

  20. The relationship between lifestyle, occupational health, and work-related factors with presenteeism amongst general practitioners.

    Science.gov (United States)

    Pit, Sabrina Winona; Hansen, Vibeke

    2016-01-01

    There is evidence that general practitioners (GPs) are more likely to exhibit sickness presenteeism than other health professional groups or other high-income earners and less likely to take sick leave. This study aims to examine the relationship between lifestyle, occupational health, and work-related factors with presenteeism amongst GPs. A cross-sectional study was conducted amongst GPs in 2011. Logistic regression was used to determine crude and adjusted odds ratios between lifestyle, occupational health, and work-related factors with presenteeism. Whilst adjusting for age and gender, exercising 1 to 3 times a week (odds ratio [OR] = 4.88), not having a good work-life balance (OR = 4.2), work-related sleep problems (OR = 2.55), moderate psychological distress (OR = 3.94), and poor or fair health (OR = 6.22) were associated with presenteeism. Increased burnout and reduced job satisfaction and workability due to the physical demands of the job were also associated with presenteeism. In conclusion, presenteeism amongst GPs can be addressed by implementing interventions in relation to physical activity, stress reduction, and sleep hygiene and improving work-life balance and the physical demands of the job.

  1. The effects of cytosine methylation on general transcription factors

    Science.gov (United States)

    Jin, Jianshi; Lian, Tengfei; Gu, Chan; Yu, Kai; Gao, Yi Qin; Su, Xiao-Dong

    2016-07-01

    DNA methylation on CpG sites is the most common epigenetic modification. Recently, methylation in a non-CpG context was found to occur widely on genomic DNA. Moreover, methylation of non-CpG sites is a highly controlled process, and its level may vary during cellular development. To study non-CpG methylation effects on DNA/protein interactions, we have chosen three human transcription factors (TFs): glucocorticoid receptor (GR), brain and muscle ARNT-like 1 (BMAL1) - circadian locomotor output cycles kaput (CLOCK) and estrogen receptor (ER) with methylated or unmethylated DNA binding sequences, using single-molecule and isothermal titration calorimetry assays. The results demonstrated that these TFs interact with methylated DNA with different effects compared with their cognate DNA sequences. The effects of non-CpG methylation on transcriptional regulation were validated by cell-based luciferase assay at protein level. The mechanisms of non-CpG methylation influencing DNA-protein interactions were investigated by crystallographic analyses and molecular dynamics simulation. With BisChIP-seq assays in HEK-293T cells, we found that GR can recognize highly methylated sites within chromatin in cells. Therefore, we conclude that non-CpG methylation of DNA can provide a mechanism for regulating gene expression through directly affecting the binding of TFs.

  2. General Open Systems Theory and the Substrata-Factor Theory of Reading.

    Science.gov (United States)

    Kling, Martin

    This study was designed to extend the generality of the Substrata-Factor Theory by two methods of investigation: (1) theoretically, to est"blish the validity of the hypothesis that an isomorphic relationship exists between the Substrata-Factor Theory and the General Open Systems Theory, and (2) experimentally, to disc"ver through a…

  3. Integrating Factors and Conservation Laws of Generalized Birkhoff System Dynamics in Event Space

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yi

    2009-01-01

    In this paper, the conservation laws or generalized Birkhoff system in event space are studied by using the method of integrating factors. Firstly, the generalized Pfaff-Birkhoff principle and the generalized Birkhoff equations are established, and the definition of the integrating factors for the system is given. Secondly, based on the concept of integrating factors, the conservation theorems and their inverse for the generalized Birkhoff system in the event space are presented in detail, and the relation between the conservation laws and the integrating factors of the system is obtained and the generalized Killing equations for the determination of the integrating factors are given. Finally, an example is given to illustrate the application of the results.

  4. Generalized Efficient Inference on Factor Models with Long-Range Dependence

    DEFF Research Database (Denmark)

    Ergemen, Yunus Emre

    . Short-memory dynamics are allowed in the common factor structure and possibly heteroskedastic error term. In the estimation, a generalized version of the principal components (PC) approach is proposed to achieve efficiency. Asymptotics for efficient common factor and factor loading as well as long...

  5. DEFINICIÓN, PREVALENCIA Y FACTORES DE RIESGOS DE INSOMNIO EN LA POBLACIÓN GENERAL Prevalence insomnia risk factors in the general population

    OpenAIRE

    Mauricio Rueda Sánchez; Luis Alfonso Díaz Martínez; Edgar Osuna Suárez

    2008-01-01

    Antecedentes. Se han informado varios factores asociados al insomnio, pero muy pocos estudios los han evaluado en forma conjunta, por lo que no se conoce su papel como factores de confusión. Objetivo. Evaluar la definición de insomnio y determinar su prevalencia en la población general y establecer la fuerza de asociación de varios factores de riesgos conocidos. Material y métodos. Estudio trasversal de 1.505 adultos seleccionados al azar en Bucaramanga, Colombia. La encuesta incluyó aspectos...

  6. Generalized vector form factors of the pion in a chiral quark model

    CERN Document Server

    Broniowski, Wojciech

    2008-01-01

    Generalized vector form factors of the pion, related to the moments of the generalized parton distribution functions, are evaluated in the Nambu--Jona-Lasinio model with the Pauli-Villars regularization. The lowest moments (the electromagnetic and the gravitational form factors) are compared to recent lattice data, with fair agreement. Predictions for higher-order moments are also made. Relevant features of the generalized form factors in the chiral quark models are highlighted and the role of the QCD evolution for the higher-order GFFs is stressed.

  7. Parallel Exhibits: Combining Physical and Virtual Exhibits

    NARCIS (Netherlands)

    L. Lischke; T. Dingler; S. Schneegaß; A. Schmidt; M. van der Vaart; P. Wozniak

    2014-01-01

    People have a special fascination for original physical objects, their texture, and visible history. However, the digitization of exhibits and the use of these data is a current challenge for museums. We believe that museums need to capitalize on the affordances of physical exhibits to help users na

  8. The Oligomeric Outer Dynein Arm Assembly Factor CCDC103 Is Tightly Integrated within the Ciliary Axoneme and Exhibits Periodic Binding to Microtubules*

    Science.gov (United States)

    King, Stephen M.; Patel-King, Ramila S.

    2015-01-01

    CCDC103 is an ∼29-kDa protein consisting of a central RPAP3_C domain flanked by N- and C-terminal coiled coils. Defects in CCDC103 lead to primary ciliary dyskinesia caused by the loss of outer dynein arms. This protein is present along the entire length of the ciliary axoneme and does not require other dynein or docking complex components for its integration. Unlike other known dynein assembly factors within the axoneme, CCDC103 is not solubilized by 0.6 m NaCl and requires more chaotropic conditions, such as 0.5 m KI. Alternatively, it can be extracted using 0.3% sarkosyl. CCDC103 forms stable dimers and other oligomers in solution through interactions involving the central domain. The smallest particle observed by dynamic light scattering has a hydrodynamic diameter of ∼25 nm. Furthermore, CCDC103 binds microtubules directly, forming ∼9-nm diameter particles that exhibit a 12-nm spacing on the microtubule lattice, suggesting that there may be two CCDC103 units per outer arm dynein repeat. Although the outer dynein arm docking complex is necessary to form arrays of dyneins along microtubules, it is not sufficient to set up a single array in a precise location on each axonemal doublet. We propose that CCDC103 helps generate a high-affinity site on the doublets for outer arm assembly, either through direct interactions or indirectly, perhaps by modifying the underlying microtubule lattice. PMID:25572396

  9. Factors Influencing the General Well-Being of Low-Income Korean Immigrant Elders

    Science.gov (United States)

    Lee, Kyoung Hag; Yoon, Dong Pil

    2011-01-01

    This study explores factors that influence the general well-being (anxiety, depression, positive well-being, self-control, vitality, and general health) of low-income Korean immigrant elders by interviewing 206 older adults living in Los Angeles County and Orange County, California. Ordinary least squares regression results reveal that lack of…

  10. [Factors influencing general practitioners and specialists of general practice to declare in favor of accepting the role of family doctors].

    Science.gov (United States)

    Lapcević, Mirjana; Dimitrijević, Ivan; Ristić, Jelena; Vuković, Mira; Nikolić, Radivoje; Stanojević, Petar

    2006-10-01

    Protection and promotion of health of an individual, family and society as the whole depends on the organization and efficiency of the public health service. Modern health service is focused on the health prevention and improvement of the family which is the basic unit of society. The life cycle of the family indicates crisis related to development and underdevelopment as well as some expected and unexpected life situations and this is very important when discussing about many somatic and mental diseases. The objective of our project which included 473 specialists of general practice and 355 general practitioners was to determine the factors which influence the positive attitude of the general practitioners about becoming a family doctor. A total of 828 doctors in Serbia were required to answer the set of eight questions. Statistical analysis included Pearson chi square test with contingency tables and logistic regression, while dependent variable was doctor's attitude about becoming a family doctor in a certain situation. The answer 'no' or 'I don't know' was scored 1 point and the 'yes' answer was graded 2 points. Eight questions mentioned above were independent variables. Logistic model accounting for 79.3% of dependent variable was obtained. Positive attitude of doctors was very much affected by family problems and great majority of these doctors were specialists of general practice. Other questions were not so important for our results. Specialists of general practice, regardless of their working experience and years of practice, gave significantly more positive answers, and the situation was quite opposite with general practitioners. Family medicine supported by modern information systems provides ideal model of comprehensive and complete health prevention with high level of rationalism, quality, efficiency and cost-effectiveness.

  11. Integrating factors and conservation theorem for holonomic nonconservative dynamical systems in generalized classical mechanics

    Institute of Scientific and Technical Information of China (English)

    乔永芬; 张耀良; 韩广才

    2002-01-01

    In this paper, we present a general approach to the construction of conservation laws for generalized classical dynamical systems. Firstly, we give the definition of integrating factors and, secondly, we study in detail the necessary conditions for the existence of conserved quantities. Then we establish the conservation theorem and its inverse for the Hamilton's canonical equations of motion of holonomic nonconservative dynamical systems in generalized classical mechanics. Finally, we give an example to illustrate the application of the results.

  12. Common genetic influences on negative emotionality and a general psychopathology factor in childhood and adolescence.

    Science.gov (United States)

    Tackett, Jennifer L; Lahey, Benjamin B; van Hulle, Carol; Waldman, Irwin; Krueger, Robert F; Rathouz, Paul J

    2013-11-01

    Previous research using confirmatory factor analysis to model psychopathology comorbidity has supported the hypothesis of a broad general factor (i.e., a "bifactor"; Holzinger & Swineford, 1937) of psychopathology in children, adolescents, and adults, with more specific higher order internalizing and externalizing factors reflecting additional shared variance in symptoms (Lahey et al., 2012; Lahey, van Hulle, Singh, Waldman, & Rathouz, 2011). The psychological nature of this general factor has not been explored, however. The current study tested a prediction, derived from the spectrum hypothesis of personality and psychopathology, that variance in a general psychopathology bifactor overlaps substantially-at both phenotypic and genetic levels-with the dispositional trait of negative emotionality. Data on psychopathology symptoms and dispositional traits were collected from both parents and youth in a representative sample of 1,569 twin pairs (ages 9-17 years) from Tennessee. Predictions based on the spectrum hypothesis were supported, with variance in negative emotionality and the general factor overlapping substantially at both phenotypic and etiologic levels. Furthermore, stronger correlations were found between negative emotionality and the general psychopathology factor than among other dispositions and other psychopathology factors.

  13. Common Genetic Influences on Negative Emotionality and a General Psychopathology Factor in Childhood and Adolescence

    Science.gov (United States)

    Tackett, Jennifer L.; Lahey, Benjamin B.; Hulle, Carol Van; Waldman, Irwin; Krueger, Robert F.; Rathouz, Paul J.

    2014-01-01

    Previous research using confirmatory factor analysis to model psychopathology comorbidity supported the hypothesis of a broad general factor (i.e., a “bifactor”; Holzinger & Swineford, 1937) of psychopathology in children, adolescents, and adults, with more specific higher-order internalizing and externalizing factors reflecting additional shared variance in symptoms (Lahey et al., 2012; Lahey, Van Hulle, Singh, Waldman, & Rathouz, 2011). The psychological nature of this general factor has not been explored, however. The current study tests a prediction derived from the spectrum hypothesis of personality and psychopathology, that variance in a general psychopathology bifactor overlaps substantially—at both phenotypic and genetic levels—with the dispositional trait of negative emotionality. Data on psychopathology symptoms and dispositional traits were collected from both parents and youth in a representative sample of 1,569 twin pairs (ages 9–17) from Tennessee. Predictions based on the spectrum hypothesis were supported, with variance in negative emotionality and the general factor overlapping substantially at both phenotypic and etiologic levels. Furthermore, stronger correlations were found between negative emotionality and the general psychopathology factor than among other dispositions and other psychopathology factors. PMID:24364617

  14. Britain exhibition at CERN

    CERN Multimedia

    Bertin; CERN PhotoLab

    1969-01-01

    The United Kingdom inaugurated the Industrial Exhibitions in 1968, and it wasn't till 1971 that other countries staged exhibitions at CERN. This photo was taken in 1969, at the second British exhibition, where 16 companies were present.

  15. The Five-Factor Model And Career Self-Efficacy: General and Domain-Specific Relationships

    Science.gov (United States)

    Hartman, Robert O.; Betz, Nancy E.

    2007-01-01

    The present study investigates the hypothesis that the big five personality factors could exert two kinds of effects on career self-efficacy: (a) generalized or nonspecific effects and (b) domain-specific, content-correspondence effects. The hypothesis is examined using relationships of the NEO Five-Factor Inventory to 24 distinct domains of…

  16. The structure of psychopathology in adolescence : Replication of a general psychopathology factor in the TRAILS study

    NARCIS (Netherlands)

    Laceulle, O.M.; Vollebergh, W.A.M.; Ormel, J.

    2015-01-01

    This study aimed to replicate a study by Caspi and colleagues, which proposed that the structure of psychopathology is characterized by a general psychopathology factor, in addition to smaller internalizing and externalizing factors. Our study expanded the approach of the original by using

  17. Designing A General Deep Web Access Approach Based On A Newly Introduced Factor; Harvestability Factor (HF)

    NARCIS (Netherlands)

    Khelghati, Mohammadreza; van Keulen, Maurice; Hiemstra, Djoerd

    2014-01-01

    The growing need of accessing more and more information draws attentions to huge amount of data hidden behind web forms defined as deep web. To make this data accessible, harvesters have a crucial role. Targeting different domains and websites enhances the need to have a general-purpose harvester

  18. Designing A General Deep Web Access Approach Based On A Newly Introduced Factor; Harvestability Factor (HF)

    NARCIS (Netherlands)

    Khelghati, Mohammadreza; Keulen, van Maurice; Hiemstra, Djoerd

    2014-01-01

    The growing need of accessing more and more information draws attentions to huge amount of data hidden behind web forms defined as deep web. To make this data accessible, harvesters have a crucial role. Targeting different domains and websites enhances the need to have a general-purpose harvester wh

  19. Designing A General Deep Web Access Approach Based On A Newly Introduced Factor; Harvestability Factor (HF)

    NARCIS (Netherlands)

    Khelghati, Mohammadreza; van Keulen, Maurice; Hiemstra, Djoerd

    2014-01-01

    The growing need of accessing more and more information draws attentions to huge amount of data hidden behind web forms defined as deep web. To make this data accessible, harvesters have a crucial role. Targeting different domains and websites enhances the need to have a general-purpose harvester wh

  20. Corticotropin-releasing factor-overexpressing mice exhibit reduced neuronal activation in the arcuate nucleus and food intake in response to fasting.

    Science.gov (United States)

    Stengel, Andreas; Goebel, Miriam; Million, Mulugeta; Stenzel-Poore, Mary P; Kobelt, Peter; Mönnikes, Hubert; Taché, Yvette; Wang, Lixin

    2009-01-01

    Corticotropin-releasing factor (CRF) overexpressing (OE) mice are a genetic model that exhibits features of chronic stress. We investigated whether the adaptive feeding response to a hypocaloric challenge induced by food deprivation is impaired under conditions of chronic CRF overproduction. Food intake response to a 16-h overnight fast and ip injection of gut hormones regulating food intake were compared in CRF-OE and wild type (WT) littermate mice along with brain Fos expression, circulating ghrelin levels, and gastric emptying of a nonnutrient meal. CRF-OE mice injected ip with saline showed a 47 and 44% reduction of 30-min and 4-h cumulative food intake response to an overnight fast, respectively, compared with WT. However, the 30-min food intake decrease induced by ip cholecystokinin (3 microg/kg) and increase by ghrelin (300 microg/kg) were similar in CRF-OE and WT mice. Overnight fasting increased the plasma total ghrelin to similar levels in CRF-OE and WT mice, although CRF-OE mice had a 2-fold reduction of nonfasting ghrelin levels. The number of Fos-immunoreactive cells induced by fasting in the arcuate nucleus was reduced by 5.9-fold in CRF-OE compared with WT mice whereas no significant changes were observed in other hypothalamic nuclei. In contrast, fasted CRF-OE mice displayed a 5.6-fold increase in Fos-immunoreactive cell number in the dorsal motor nucleus of the vagus nerve and a 34% increase in 20-min gastric emptying. These findings indicate that sustained overproduction of hypothalamic CRF in mice interferes with fasting-induced activation of arcuate nucleus neurons and the related hyperphagic response.

  1. AST1306, a novel irreversible inhibitor of the epidermal growth factor receptor 1 and 2, exhibits antitumor activity both in vitro and in vivo.

    Directory of Open Access Journals (Sweden)

    Hua Xie

    Full Text Available Despite the initial response to the reversible, ATP-competitive quinazoline inhibitors that target ErbB-family, such a subset of cancer patients almost invariably develop resistance. Recent studies have provided compelling evidence that irreversible ErbB inhibitors have the potential to override this resistance. Here, we found that AST1306, a novel anilino-quinazoline compound, inhibited the enzymatic activities of wild-type epidermal growth factor receptor (EGFR and ErbB2 as well as EGFR resistant mutant in both cell-free and cell-based systems. Importantly, AST1306 functions as an irreversible inhibitor, most likely through covalent interaction with Cys797 and Cys805 in the catalytic domains of EGFR and ErbB2, respectively. Further studies showed that AST1306 inactivated pathways downstream of these receptors and thereby inhibited the proliferation of a panel of cancer cell lines. Although the activities of EGFR and ErbB2 were similarly sensitive to AST1306, ErbB2-overexpressing cell lines consistently exhibited more sensitivity to AST1306 antiproliferative effects. Consistent with this, knockdown of ErbB2, but not EGFR, decreased the sensitivity of SK-OV-3 cells to AST1306. In vivo, AST1306 potently suppressed tumor growth in ErbB2-overexpressing adenocarcinoma xenograft and FVB-2/N(neu transgenic breast cancer mouse models, but weakly inhibited the growth of EGFR-overexpressing tumor xenografts. Tumor growth inhibition induced by a single dose of AST1306 in the SK-OV-3 xenograft model was accompanied by a rapid (within 2 h and sustained (≥24 h inhibition of both EGFR and ErbB2, consistent with an irreversible inhibition mechanism. Taken together, these results establish AST1306 as a selective, irreversible ErbB2 and EGFR inhibitor whose growth-inhibitory effects are more potent in ErbB2-overexpressing cells.

  2. The DSM-5 dimensional trait model and five-factor models of general personality.

    Science.gov (United States)

    Gore, Whitney L; Widiger, Thomas A

    2013-08-01

    The current study tests empirically the relationship of the dimensional trait model proposed for the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) with five-factor models of general personality. The DSM-5 maladaptive trait dimensional model proposal included 25 traits organized within five broad domains (i.e., negative affectivity, detachment, antagonism, disinhibition, and psychoticism). Consistent with the authors of the proposal, it was predicted that negative affectivity would align with five-factor model (FFM) neuroticism, detachment with FFM introversion, antagonism with FFM antagonism, disinhibition with low FFM conscientiousness and, contrary to the proposal; psychoticism would align with FFM openness. Three measures of alternative five-factor models of general personality were administered to 445 undergraduates along with the Personality Inventory for DSM-5. The results provided support for the hypothesis that all five domains of the DSM-5 dimensional trait model are maladaptive variants of general personality structure, including the domain of psychoticism.

  3. Medical ultrasound imaging method combining minimum variance beamforming and general coherence factor

    Institute of Scientific and Technical Information of China (English)

    WU Wentao; PU Jie; LU Yi

    2012-01-01

    In medical ultrasound imaging field, in order to obtain high resolution and correct the phase errors induced by the velocity in-homogeneity of the tissue, a high-resolution medical ultrasound imaging method combining minimum variance beamforming and general coherence factor was presented. First, the data from the elements is delayed for focusing; then the multi-channel data is used for minimum variance beamforming; at the same time, the data is transformed from array space to beam space to calculate the general coherence factor; in the end, the general coherence factor is used to weight the results of minimum variance beamforming. The medical images are gotten by the imaging system. Experiments based on point object and anechoic cyst object are used to verify the proposed method. The results show the proposed method in the aspects of resolution, contrast and robustness is better than minimum variance beamforming and conventional beamforming.

  4. Exact expression for decoherence factor in the time-dependent generalized Cini model

    Institute of Scientific and Technical Information of China (English)

    Jianqi Shen(沈建其); Sanshui Xiao(肖三水); Qiang Wu(武强)

    2003-01-01

    The present letter finds the complete set of exact solutions of the time-dependent generalized Cini modelby making use of the Lewis-Riesenfeld invariant theory and the invariant-related unitary transformationformulation and, based on this, the general explicit expression for the decoherence factor is thereforeobtained. This study provides us with a useful method to consider the geometric phase and topologicalproperties in the time-dependent quantum decoherence process.

  5. Psychological consequences of screening for cardiovascular risk factors in an un-selected general population

    DEFF Research Database (Denmark)

    Løkkegaard, Thomas; Andersen, John S; Jacobsen, Rikke K

    2015-01-01

    screening in healthy adults leads to mental distress in the study population, independent of participation. Methods: The Inter99 study (1999 – 2006) was a randomised intervention in the general population, aiming to prevent IHD by a healthier lifestyle. We included the whole study population, independent......Background: Concerns that general health checks, including screening for risk factors to ischemic heart disease (IHD),have negative psychological consequences seem widely unfounded; however, previous studies are only based on selfreports from participants. Aim: To investigate if risk factor...

  6. Mycoplasma genitalium: prevalence and behavioural risk factors in the general population

    DEFF Research Database (Denmark)

    Andersen, Berit; Sokolowski, Ineta; Østergaard, Lars;

    2007-01-01

    BACKGROUND: Mycoplasma genitalium has been shown to cause urethritis in men and cervicitis in women and may also be a causative agent in female infertility. OBJECTIVE: To estimate the prevalence of urogenital M genitalium infection and identify sexual behavioural risk factors in the general......, and for men younger age at first intercourse was associated with M genitalium infection. CONCLUSIONS: We conclude that the prevalence of infection in the general population is too low for population-based screening. However, the development of test algorithms based on behavioural risk factors is a promising...

  7. Is there a genetic correlation between general factors of intelligence and personality?

    Science.gov (United States)

    Loehlin, John C; Bartels, Meike; Boomsma, Dorret I; Bratko, Denis; Martin, Nicholas G; Nichols, Robert C; Wright, Margaret J

    2015-06-01

    We tested a hypothesis that there is no genetic correlation between general factors of intelligence and personality, despite both having been selected for in human evolution. This was done using twin samples from Australia, the United States, the Netherlands, Great Britain, and Croatia, comprising altogether 1,748 monozygotic and 1,329 same-sex dizygotic twin pairs. Although parameters in the model-fitting differed among the twin samples, the genetic correlation between the two general factors could be set to zero, with a better fit if the U.S. sample was excepted.

  8. Choosing Surgery: Identifying Factors Leading to Increased General Surgery Matriculation Rate.

    Science.gov (United States)

    Pointer, David T; Freeman, Matthew D; Korndorffer, James R; Meade, Peter C; Jaffe, Bernard M; Slakey, Douglas P

    2017-03-01

    Tulane graduates have, over the past six years, chosen general surgical residency at a rate above the national average (mean 9.6% vs 6.6%). With much of the recent career choice research focusing on disincentives and declining general surgery applicants, we sought to identify factors that positively influenced our students' decision to pursue general surgery. A 50-question survey was developed and distributed to graduates who matched into a general surgery between the years 2006 and 2014. The survey evaluated demographics, exposure to surgery, and factors affecting interest in a surgical career. We achieved a 54 per cent (61/112) response rate. Only 43 per cent considered a surgical career before medical school matriculation. Fifty-nine per cent had strongly considered a career other than surgery. Sixty-two per cent chose to pursue surgery during or immediately after their surgery clerkship. The most important factors cited for choosing general surgery were perceived career enjoyment of residents and faculty, resident/faculty relationship, and mentorship. Surgery residents and faculty were viewed as role models by 72 and 77 per cent of responders, respectively. This study demonstrated almost half of those choosing a surgical career did so as a direct result of the core rotation experience. We believe that structuring the medical student education experience to optimize the interaction of students, residents, and faculty produces a positive environment encouraging students to choose a general surgery career.

  9. Liu Hong: no trivial on exhibitions

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    To Work for Tomorrow Liu Hong, General Manager of TUTTI Exhibition Service (Xiamen) Co., Ltd, has set up TUTTI Exhibition Service (Xiamen) Co., Ltd in 2001, when exhibition industry firstly appear in Xiamen. Furthermore, the company has developed rapidly in recent years. As Liu Hong regards, exhibition industry, as well as advertisement industry, is an industry filled with challenges and followed

  10. The Structure of Multidimensional Perfectionism: Support for a Bifactor Model With a Dominant General Factor.

    Science.gov (United States)

    Smith, Martin M; Saklofske, Donald H

    2016-08-05

    Evidence suggests perfectionism is a multidimensional construct composed of 2 higher order factors: perfectionistic strivings and perfectionistic concerns. However, the substantial overlap between perfectionistic strivings and perfectionistic concerns is problematic, as are the unanswered questions regarding the structure of perfectionism following removal of common variance. This research addressed this through bifactor modeling. Three student samples (N = 742) completed Hewitt and Flett's ( 1991 ) Multidimensional Perfectionism Scale, Frost, Marten, Lahart, and Rosenblate's ( 1990 ) Multidimensional Perfectionism Scale, and Slaney, Rice, Mobley, Trippi, and Ashby's ( 2001 ) Almost Perfect Scale-Revised. Greater support was consistently found for the bifactor model, relative to the 2-factor model. Results suggest the bifactor model best represents the structure of perfectionism and provide preliminary support for the use of a general factor score. Researchers are cautioned that removal of general variance may render the reliability of specific factors (i.e., perfectionistic strivings and perfectionistic concerns) suspect.

  11. Digital collections and exhibits

    CERN Document Server

    Denzer, Juan

    2015-01-01

    Today's libraries are taking advantage of cutting-edge technologies such as flat panel displays using touch, sound, and hands-free motions to design amazing exhibits using everything from simple computer hardware to advanced technologies such as the Microsoft Kinect. Libraries of all types are striving to add new interactive experiences for their patrons through exciting digital exhibits, both online and off. Digital Collections and Exhibits takes away the mystery of designing stunning digital exhibits to spotlight library trea

  12. Safety Factor of Anisotropic Bars in the Space of Generalized Forces

    Science.gov (United States)

    Sibgatullin, K. E.; Sibgatullin, E. S.

    2017-01-01

    Bars of arbitrary shape made of a homogeneous anisotropic material are considered. In the general case, in their cross section, nonzero are all internal force factors (IFF) — three forces and three moments. The values of the IFF are known from solutions of the corresponding problem. The safety factor for the load-carrying capacity of the beams is determined by comparing the known vector R ∗ of IFF with the corresponding desired strength vector R in the IFF space.

  13. Integrating Factors and Conservation Theorems of Lagrangian Equations for Nonconservative Mechanical System in Generalized Classical Mechanics

    Institute of Scientific and Technical Information of China (English)

    QIAO Yong-Fen; ZHAO Shu-Hong

    2006-01-01

    The conservation theorems of the generalized Lagrangian equations for nonconservative mechanical system are studied by using method of integrating factors. Firstly, the differential equations of motion of system are given, and the definition of integrating factors is given. Next, the necessary conditions for the existence of the conserved quantity are studied in detail. Finally, the conservation theorem and its inverse for the system are established, and an example is given to illustrate the application of the result.

  14. Etruscan Culture Exhibition

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    EARLY this year an exhibition on the ancient civilization of Etruria was held at the Beijing-based China Millennium Monument.The theme of the exhibition was Etruscan Culture and on show were the most representative cultural and historical relics of this ancient civilization unearthed in the past 20 years. The 349 exhibits from various

  15. Ethics on Exhibit

    Science.gov (United States)

    Vick, Randy M.

    2011-01-01

    This article discusses ethical questions raised by an exhibition of work by an artist with a history of mental illness and the exhibition's relevance to art therapy and “outsider art” discourse on the subject. Considerations for how such an exhibit could be handled had the circumstances included an art therapist and art therapy client are…

  16. Report on Exhibition Industry in Shanghai

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ 1. General Characteristics of Shanghai Exhibitions As the leader of economic development in the Yangtze River Delta,Shanghai has basically formed a certain scale and strength in the aspects of urban transportation, exhibition venues, supporting facilities, service levels, etc.

  17. Advances on BYY harmony learning: information theoretic perspective, generalized projection geometry, and independent factor autodetermination.

    Science.gov (United States)

    Xu, Lei

    2004-07-01

    The nature of Bayesian Ying-Yang harmony learning is reexamined from an information theoretic perspective. Not only its ability for model selection and regularization is explained with new insights, but also discussions are made on its relations and differences from the studies of minimum description length (MDL), Bayesian approach, the bit-back based MDL, Akaike information criterion (AIC), maximum likelihood, information geometry, Helmholtz machines, and variational approximation. Moreover, a generalized projection geometry is introduced for further understanding such a new mechanism. Furthermore, new algorithms are also developed for implementing Gaussian factor analysis (FA) and non-Gaussian factor analysis (NFA) such that selecting appropriate factors is automatically made during parameter learning.

  18. Impact factor trends for general medical journals: non-English-language journals are lagging behind

    DEFF Research Database (Denmark)

    Vinther, Siri; Rosenberg, Jacob

    2012-01-01

    The impact factor (IF) is a common citation metric used for evaluating and comparing scientific journals within a certain field. Previous studies have shown that IFs are increasing. However, rates may depend on journal publication language. The aim of this study was to determine IF values...... and trends for general medical journals, comparing non-English-language with English-language journals....

  19. The General Factor of Personality (GFP) and parental support: Testing a prediction from Life History Theory

    NARCIS (Netherlands)

    Linden, D. van der; Figueredo, A.J.; Leeuw, R.N.H. de; Scholte, R.H.J.; Engels, R.C.M.E.

    2012-01-01

    In the present study, we tested whether the General Factor of Personality (GFP) is related to the level of parental support. The GFP is assumed to occupy the apex of the hierarchy of human personality structure and is believed to reflect a socially and sexually selected aggregate of behavioral chara

  20. The Factor Structure and Dimensional Scoring of the Generalized Anxiety Disorder Questionnaire for "DSM-IV"

    Science.gov (United States)

    Rodebaugh, Thomas L.; Holaway, Robert M.; Heimberg, Richard G.

    2008-01-01

    Despite favorable psychometric properties, the Generalized Anxiety Disorder Questionnaire for the "Diagnostic and Statistical Manual of Mental Disorders" (4th ed.) (GAD-Q-IV) does not have a known factor structure, which calls into question use of its original weighted scoring system (usually referred to as the dimensional score).…

  1. Culture-General and Culture-Specific Factors in the Discrimination of Melodies.

    Science.gov (United States)

    Schellenberg, E. Glenn; Trehub, Sandra E.

    1999-01-01

    Two experiments examined the effects of a culture-general factor, pattern redundancy, on the discrimination of five-tone melodies that differed in their adherence to Western tonal conventions, among 9-month olds, 5-year olds, and adults. Increasing exposure seemed to attenuate the effects of the pattern redundancy while amplifying the influence of…

  2. Nucleon generalized form factors and sigma term from lattice QCD near the physical quark mass

    CERN Document Server

    Bali, G S; Gläßle, B; Göckeler, M; Najjar, J; Rödl, R; Schäfer, A; Schiel, R; Söldner, W; Sternbeck, A; Wein, P

    2013-01-01

    We present new N_f=2 data for the nucleon generalized form factors, varying volume, lattice spacing and pion mass, down to 150 MeV. We also give an update of our direct calculation of the nucleon sigma term for a range of pion mass values including the lightest one.

  3. Monte Carlo direct view factor and generalized radiative heat transfer programs

    Science.gov (United States)

    Mc Williams, J. L.; Scates, J. H.

    1969-01-01

    Computer programs find the direct view factor from one surface segment to another using the Monte carlo technique, and the radioactive-transfer coefficients between surface segments. An advantage of the programs is the great generality of problems treatable and rapidity of solution from problem conception to receipt of results.

  4. Cerebrovascular risk factors and subsequent depression in older general practice patients

    NARCIS (Netherlands)

    Nuyen, Jasper; Spreeuwenberg, Peter M.; Beekman, Aartjan T.F.; Groenewegen, Peter P.; Bos, Geertrudis A.M. van den; Schellevis, Francois G.

    2007-01-01

    Background: This general practice-based case-control study tested the association between cerebrovascular risk factors (CVRFs) and the development of later-life depression by focusing on the impact of exposure duration to CVRFs and the modifying influence of age at depression onset. Methods: Cases w

  5. Cerebrovascular risk factors and subsequent depression in older general practice patients.

    NARCIS (Netherlands)

    Nuyen, J.; Spreeuwenberg, P.M.; Beekman, A.T.F.; Groenewegen, P.P.; Bos, G.A.M. van den; Schellevis, F.G.

    2007-01-01

    Background: This general practice-based case-control study tested the association between cerebrovascular risk factors (CVRFs) and the development of later-life depression by focusing on the impact of exposure duration to CVRFs and the modifying influence of age at depression onset. Methods: Cases w

  6. Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE.

    Science.gov (United States)

    Ohkuma, Y; Sumimoto, H; Hoffmann, A; Shimasaki, S; Horikoshi, M; Roeder, R G

    1991-12-05

    The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits of relative molecular mass 57,000 (TFIIE-alpha) and 34,000 (TFIIE-beta) and joins the preinitiation complex after RNA polymerase II and TFIIF. Here we report the cloning and structure of a complementary DNA encoding a functional human TFIIE-alpha. TFIIE-alpha is necessary for transcription initiation together with TFIIE-beta, and recombinant TFIIE-alpha can fully replace the natural subunit in an in vitro transcription assay. The sequence contains several interesting structural motifs (leucine repeat, zinc finger and helix-turn-helix) and sequence similarities to bacterial sigma factors that suggest direct involvement in the regulation of transcription initiation.

  7. Exhibiting Mozart: Rethinking Biography

    OpenAIRE

    Spring, Ulrike

    2010-01-01

    Abstract: The article analyses the new permanent exhibition in the composer Wolfgang A. Mozart’s apartment in Vienna, opened in 2006, from the curator’s perspective. The exhibition presents an approach to biographical display in which the exhibited person becomes part of a multifaceted web of contexts, and the article argues for the active deployment of the polysemic character of objects as a means of grasping the complexity of a person’s biography. Presenting a concept for the...

  8. Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis.

    Science.gov (United States)

    Chatterjee, Anwesha; Ronghe, Amruta; Singh, Bhupendra; Bhat, Nimee K; Chen, Jie; Bhat, Hari K

    2014-12-01

    The objective of the present study was to characterize the role of resveratrol (Res) and vitamin C (VC) in prevention of estrogen-induced breast cancer through regulation of cap "n"collar (CNC) b-zip transcription factors. Human breast epithelial cell line MCF-10A was treated with 17β-estradiol (E2) and VC or Res with or without E2. mRNA and protein expression levels of CNC b-zip transcription factors nuclear factor erythroid 2-related factor 1 (Nrf1), nuclear factor erythroid 2 related factor 2 (Nrf2), nuclear factor erythroid 2 related factor 3 (Nrf3), and Nrf2-regulated antioxidant enzymes superoxide dismutase 3 (SOD3) and quinone oxidoreductase 1 (NQO1) were quantified. The treatment with E2 suppressed, whereas VC and Res prevented E2-mediated decrease in the expression levels of SOD3, NQO1, Nrf2 mRNA, and protein in MCF-10A cells. The treatment with E2, Res, or VC significantly increased mRNA and protein expression levels of Nrf1. 17β-Estradiol treatment significantly increased but VC or Res decreased Nrf3 mRNA and protein expression levels. Our studies demonstrate that estrogen-induced breast cancer might be prevented through upregulation of antioxidant enzymes via Nrf-dependent pathways. © 2014 Wiley Periodicals, Inc.

  9. Internal consistency and factor structure of 12-item general health questionnaire in visually impaired students

    Directory of Open Access Journals (Sweden)

    Ajay Kumar Bakhla

    2013-01-01

    Full Text Available Background: As there are no instruments to measure psychological wellness or distress in visually impaired students, we studied internal consistency and factor structure of GHQ-12 in visually impaired children. Materials and Methods: Internal consistency analysis (Cronbach′s alpha and item total correlation and exploratory factor analysis (principal component analysis were carried out to identify factor structure of 12-item general health questionnaire (GHQ-12. Results: All items of GHQ-12 were significantly associated with each other and the Cronbach′s alpha coefficient for the scale was 0.7. On analysis of principal component, three-factor solution was found that accounted for 47.92% of the total variance. The factors included, ′general well-being′, ′depression′ and ′cognitive′, with Cronbach′s alpha coefficients being 0.70, 0.59, and 0.34, respectively. Conclusion: Our study findings suggest GHQ-12 is a reliable with adequate internal consistency scale and multidimensional factor structure in visually impaired students.

  10. DEFINICIÓN, PREVALENCIA Y FACTORES DE RIESGOS DE INSOMNIO EN LA POBLACIÓN GENERAL Prevalence insomnia risk factors in the general population

    Directory of Open Access Journals (Sweden)

    Mauricio Rueda Sánchez

    2008-03-01

    Full Text Available Antecedentes. Se han informado varios factores asociados al insomnio, pero muy pocos estudios los han evaluado en forma conjunta, por lo que no se conoce su papel como factores de confusión. Objetivo. Evaluar la definición de insomnio y determinar su prevalencia en la población general y establecer la fuerza de asociación de varios factores de riesgos conocidos. Material y métodos. Estudio trasversal de 1.505 adultos seleccionados al azar en Bucaramanga, Colombia. La encuesta incluyó aspectos sobre percepción y síntomas de insomnio, factores sociodemográficos, de estilo de vida y de la condición de salud. Para ajustar la potencial confusión, se generaron modelos de regresión logística polinomial. Resultados. El 11.4 por ciento (IC95% 9.7-13.1 de las personas encuestadas dicen tener problemas de sueño; el 63.6 por ciento (IC95% 61.0-66.3 referían al menos un síntoma de insomnio pero sin consecuencias al otro día y el 26.2 por ciento (IC95% 23.7-28.7 manifestaron tener al menos un síntoma de insomnio y consecuencias del insomnio durante el día siguiente. Los factores de riesgo asociados al insomnio con consecuencias diurnas son la edad (OR 2.079, referir estar sufriendo actualmente maltrato físico (OR 17.704 y tener dificultades en varios aspectos de la vida tales como dificultades laborales, económicas, de pareja o familiares, entre otras (OR 4.437, mientras que es un factor protector tener educación secundaria o universitaria (OR 0.649 y 0.511, respectivamente. No se halló asociación con historia de enfermedades serias, género, nivel socioeconómico o consumo de alcohol o café. Conclusión. La mejor definición de insomnio es la combinación de síntomas de insomnio y consecuencias durante el día. La prevalencia de insomnio es alta y se asocia con algunos de los factores previamente descritos en la literatura, pero no con otros, lo que pone de manifiesto la necesidad de que al realizar estudios se incluyan todas las

  11. Becoming a general practitioner--which factors have most impact on career choice of medical students?

    Science.gov (United States)

    Kiolbassa, Kathrin; Miksch, Antje; Hermann, Katja; Loh, Andreas; Szecsenyi, Joachim; Joos, Stefanie; Goetz, Katja

    2011-05-09

    In Germany, there is a shortage of young physicians in several specialties, the situation of general practitioners (GP) being especially precarious. The factors influencing the career choice of German medical students are poorly understood. This study aims to identify factors influencing medical students' specialty choice laying a special focus on general practice. The study was designed as a cross-sectional survey. In 2010, students at the five medical schools in the federal state of Baden-Wuerttemberg (Germany) filled out an online-questionnaire. On 27 items with 5-point Likert scales, the students rated the importance of specified individual and occupational aspects. Furthermore, students were asked to assign their intended medical specialty. 1,299 students participated in the survey. Thereof, 1,114 students stated a current choice for a specialty, with 708 students choosing a career in one of the following 6 specialties: internal medicine, surgery, gynaecology and obstetrics, paediatrics, anaesthetics and general practice. Overall, individual aspects ('Personal ambition', 'Future perspective', 'Work-life balance') were rated as more important than occupational aspects (i.e. 'Variety in job', 'Job-related ambition') for career choice. For students favouring a career as a GP individual aspects and the factor 'Patient orientation' among the occupational aspects were significantly more important and 'Job-related ambition' less important compared to students with other specialty choices. This study confirms that future GPs differ from students intending to choose other specialties particularly in terms of patient-orientation and individual aspects such as personal ambition, future perspective and work-life balance. Improving job-conditions in terms of family compatibility and work-life balance could help to increase the attractiveness of general practice. Due to the shortage of GPs those factors should be made explicit at an early stage at medical school to increase

  12. Becoming a general practitioner - Which factors have most impact on career choice of medical students?

    Directory of Open Access Journals (Sweden)

    Loh Andreas

    2011-05-01

    Full Text Available Abstract Background In Germany, there is a shortage of young physicians in several specialties, the situation of general practitioners (GP being especially precarious. The factors influencing the career choice of German medical students are poorly understood. This study aims to identify factors influencing medical students' specialty choice laying a special focus on general practice. Methods The study was designed as a cross-sectional survey. In 2010, students at the five medical schools in the federal state of Baden-Wuerttemberg (Germany filled out an online-questionnaire. On 27 items with 5-point Likert scales, the students rated the importance of specified individual and occupational aspects. Furthermore, students were asked to assign their intended medical specialty. Results 1,299 students participated in the survey. Thereof, 1,114 students stated a current choice for a specialty, with 708 students choosing a career in one of the following 6 specialties: internal medicine, surgery, gynaecology and obstetrics, paediatrics, anaesthetics and general practice. Overall, individual aspects ('Personal ambition', 'Future perspective', 'Work-life balance' were rated as more important than occupational aspects (i.e. 'Variety in job', 'Job-related ambition' for career choice. For students favouring a career as a GP individual aspects and the factor 'Patient orientation' among the occupational aspects were significantly more important and 'Job-related ambition' less important compared to students with other specialty choices. Conclusions This study confirms that future GPs differ from students intending to choose other specialties particularly in terms of patient-orientation and individual aspects such as personal ambition, future perspective and work-life balance. Improving job-conditions in terms of family compatibility and work-life balance could help to increase the attractiveness of general practice. Due to the shortage of GPs those factors should

  13. Maternal factors associated with fetal growth and birthweight are independent determinants of placental weight and exhibit differential effects by fetal sex.

    Directory of Open Access Journals (Sweden)

    Marie Cecilie Paasche Roland

    Full Text Available INTRODUCTION: Maternal nutritional and metabolic factors influence the developmental environment of the fetus. Virtually any nutritional factor in the maternal blood has to pass the placental membranes to reach the fetal blood. Placental weight is a commonly used measure to summarize placental growth and function. Placental weight is an independent determinant of fetal growth and birthweight and modifies the associations between maternal metabolic factors and fetal growth. We hypothesized that maternal factors known to be related to fetal growth, newborn size and body composition are determinants of placental weight and that effects of maternal metabolic factors on placental weight differ between the genders. METHODS: The STORK study is a prospective longitudinal study including 1031 healthy pregnant women of Scandinavian heritage with singleton pregnancies. Maternal determinants (parity, body mass index, gestational weight gain and fasting plasma glucose of placental weight were explored by linear regression models, stratified by fetal sex. RESULTS: Parity, maternal BMI, gestational weight gain and fasting glucose had positive effects on placental weight. There was a sex specific effect in these associations. Fasting glucose was significantly associated with placental weight in females but not in males. CONCLUSION: Maternal factors known to influence fetal growth, birthweight and neonatal body composition are determinants of placental weight. The effect of maternal factors on placental weight is influenced by sex as illustrated in the relation between maternal glucose and placental weight.

  14. Drell-Yan process with jet vetoes: breaking of generalized factorization

    CERN Document Server

    Zeng, Mao

    2015-01-01

    Resummation of hadron collision cross sections, when the measurement imposes a hierarchy of scales, relies on factorization. Cancellation of Glauber / Coulomb gluons is a necessary condition for factorization. For Drell-Yan-like processes, the known proofs of cancellation of Glauber gluons are not applicable when jet vetoes are introduced, via jet algorithms or event shape variables such as the beam thrust. A priori, this does not rule out the possibility that an unknown new cancellation mechanism exists, or the possibility that a generalized factorization formalism is correct. To resolve the questions, we construct a direct counter-example in QCD with scalar quarks, contradicting any form of factorization in which the two collinear sectors are decoupled from each other. In the counter-example, decoupling of the two collinear sectors implies zero dependence of the beam thrust distribution on the longitudinal spin of the incoming hadrons, but we find a non-zero spin asymmetry at leading power due to Glauber gl...

  15. Various methods of numerical estimation of generalized stress intensity factors of bi-material notches

    Directory of Open Access Journals (Sweden)

    Klusák J.

    2009-12-01

    Full Text Available The study of bi-material notches becomes a topical problem as they can model efficiently geometrical or material discontinuities. When assessing crack initiation conditions in the bi-material notches, the generalized stress intensity factors H have to be calculated. Contrary to the determination of the K-factor for a crack in an isotropic homogeneous medium, for the ascertainment of the H-factor there is no procedure incorporated in the calculation systems. The calculation of these fracture parameters requires experience. Direct methods of estimation of H-factors need choosing usually length parameter entering into calculation. On the other hand the method combining the application of the reciprocal theorem (Ψ-integral and FEM does not require entering any length parameter and is capable to extract the near-tip information directly from the far-field deformation.

  16. Incidence and risk factors for suicide attempts in a general population of young people

    DEFF Research Database (Denmark)

    Christiansen, Erik; Larsen, Kim Juul; Agerbo, Esben;

    2013-01-01

    OBJECTIVE: To estimate the Danish epidemiological long-term incidence rates for suicide attempts in the general population of children and adolescents, and to analyze the impact from single and multiple risk factors on the risk of suicide attempts. METHOD: We used longitudinal register data from...... a total cohort of all individuals born between 1983 and 1989 and living in Denmark to calculate incidence rates. From the cohort, we identified all who have attempted suicide, and matched 50 controls to each case. A nested case-control design was used to estimate the impact from risk factors on the risk...... for index suicide attempts. We established a link to the biological parents and identified risk factors for two generations. Risk factors were analyzed in a conditional logistic regression model. RESULTS: We identified 3718 suicide attempters and 185,900 controls (189,618 individuals, aged 10-21 years). We...

  17. Factor structure and reliability of the 12-item Sinhala version of General Health Questionnaire

    Directory of Open Access Journals (Sweden)

    Chrishantha Abeysena

    2012-08-01

    Full Text Available Introduction: The General Health Questionnaire (GHQ is widely used to detect common psychiatric disorders. Even though the GHQ 12 has been validated for many countries, psychometric properties in relation to the Sinhala speaking Sri Lankan population lack conclusive evidence. Objective: To determine the factor structure and the reliability of the Sinhala version of GHQ 12. Methods: This was a descriptive study including 385 patients with in the age range of 18 to 75 years, attending the Out Patient Department of Colombo North Teaching Hospital, Ragama, Sri Lanka, between June 2009 to September 2010. Sinhala version of GHQ-12 was completed by the participants. Each item of the GHQ was rated on a four-point scale (0-1-2-3. Factor analyses were performed by applying Generalized Least Squares method using oblimin rotation. The internal consistency was assessed by calculating Cronbach’s α coefficient.Results: Median age of the study population was 32.5 years (IQR= 21years and the median GHQ score was 9 (IQR=7. The GHQ 12 yielded two factor solutions. Factor I (Depression and Anxiety accounted for 88% of the total explained variance and Factor II (Social dysfunction 12%. Forty five percent (45% of the total variance could be explained by the two extracted factors. There was a clear distinction between the items that loaded on the two factors. The correlation coefficient between the factors I and II was 0.65. The Cronbach's alpha of GHQ 12 was 0.88, which indicated satisfactory internal consistency. Conclusions: GHQ 12 displays adequate reliability and validity for use in the Sinhala speaking primary care attendees of Colombo North Teaching Hospital for assessing psychiatric disorders.

  18. Accident-precipitating factors for crashes in turbine-powered general aviation aircraft.

    Science.gov (United States)

    Boyd, Douglas D; Stolzer, Alan

    2016-01-01

    General aviation (14CFR Part 91) accounts for 83% of civil aviation fatalities. While much research has focused on accident causes/pilot demographics in this aviation sector, studies to identify factors leading up to the crash (accident-precipitating factors) are few. Such information could inform on pre-emptive remedial action. With this in mind and considering the paucity of research on turbine-powered aircraft accidents the study objectives were to identify accident-precipitating factors and determine if the accident rate has changed over time for such aircraft operating under 14CFR Part 91. The NTSB Access database was queried for accidents in airplanes (engines and occurring between 1989 and 2013. We developed and utilized an accident-precipitating factor taxonomy. Statistical analyses employed logistic regression, contingency tables and a generalized linear model with Poisson distribution. The "Checklist/Flight Manual Not Followed" was the most frequent accident-precipitating factor category and carried an excess risk (OR 2.34) for an accident with a fatal and/or serious occupant injury. This elevated risk reflected an over-representation of accidents with fatal and/or serious injury outcomes (pengine aircraft are more frequent than their single engine counterparts and the decline (50%) in the turbine aircraft accident rate over the study period was likely due, in part, to a 6-fold increased representation of single engine airplanes. In conclusion, our study is the first to identify novel precursive factors for accidents involving turbine aircraft operating under 14CFR Part 91. This research highlights areas that should receive further emphasis in training/recurrency in a pre-emptive attempt to nullify candidate accident-precipitating factor(s).

  19. General polynomial factorization-based design of sparse periodic linear arrays.

    Science.gov (United States)

    Mitra, Sanjit K; Mondal, Kalyan; Tchobanou, Mikhail K; Dolecek, Gordana Jovanovic

    2010-09-01

    We have developed several methods of designing sparse periodic arrays based upon the polynomial factorization method. In these methods, transmit and receive aperture polynomials are selected such that their product results in a polynomial representing the desired combined transmit/receive (T/R) effective aperture function. A desired combined T/R effective aperture is simply an aperture with an appropriate width exhibiting a spectrum that corresponds to the desired two-way radiation pattern. At least one of the two aperture functions that constitute the combined T/R effective aperture function will be a sparse polynomial. A measure of sparsity of the designed array is defined in terms of the element reduction factor. We show that elements of a linear array can be reduced with varying degrees of beam mainlobe width to sidelobe reduction properties.

  20. CONTRIBUICIONES DEL FACTOR GENERAL Y DE LOS FACTORES ESPECIFICOS EN LA RELACION ENTRE INTELIGENCIA Y RENDIMIENTO ESCOLAR

    OpenAIRE

    Almeida, Leandro S.; Guisande,M. Adelina; Ricardo, Primi; Lemos, Gina C.

    2008-01-01

    Resumen: En este artículo se pretende analizar en qué medida, factores más específicos de la cognición, asociados a contenido verbal, numérico o figurativo, complementan un factor más general de raciocinio en la predicción del rendimiento escolar de los alumnos, al inicio y final de la adolescencia. A una muestra de estudiantes portugueses (n=4.899) entre el 5º y el 12º año de escolaridad, se le aplicó una Batería de Pruebas de Raciocinio en sus tres versiones. El rendimiento escolar de los a...

  1. Form Factors and Generalized Parton Distributions in Basis Light-Front Quantization

    CERN Document Server

    Adhikari, Lekha; Zhao, Xingbo; Maris, Pieter; Vary, James P; El-Hady, Alaa Abd

    2016-01-01

    We calculate the elastic form factors and the Generalized Parton Distributions (GPDs) for four low-lying bound states of a demonstration fermion-antifermion system, strong coupling positronium ($e \\bar{e}$), using Basis Light-Front Quantization (BLFQ). Using this approach, we also calculate the impact-parameter dependent GPDs $q(x, {\\vec b_\\perp})$ to visualize the fermion density in the transverse plane (${\\vec b_\\perp}$). We compare selected results with corresponding quantities in the non-relativistic limit to reveal relativistic effects. Our results establish the foundation within BLFQ for investigating the form factors and the GPDs for hadronic systems.

  2. Near Threshold Neutral Pion Electroproduction at High Momentum Transfers and Generalized Form Factors

    CERN Document Server

    Khetarpal, P; Aznauryan, I G; Kubarovsky, V; Adhikari, K P; Adikaram, D; Aghasyan, M; Amaryan, M J; Anderson, M D; Pereira, S Anefalos; Anghinolfi, M; Avakian, H; Baghdasaryan, H; Ball, J; Baltzell, N A; Battaglieri, M; Batourine, V; Bedlinskiy, I; Biselli, A S; Bono, J; Boiarinov, S; Briscoe, W J; Brooks, W K; Burkert, V D; Carman, D S; Celentano, A; Charles, G; Cole, P L; Contalbrigo, M; Crede, V; D'Angelo, A; Dashyan, N; De Vita, R; De Sanctis, E; Deur, A; Djalali, C; Doughty, D; Dugger, M; Dupre, R; Egiyan, H; Alaoui, A El; Fassi, L El; Eugenio, P; Fedotov, G; Fegan, S; Fersch, R; Fleming, J A; Fradi, A; Gabrielyan, M Y; Garçon, M; Gevorgyan, N; Gilfoyle, G P; Giovanetti, K L; Girod, F X; Goetz, J T; Gohn, W; Golovatch, E; Gothe, R W; Griffioen, K A; Guegan, B; Guidal, M; Guo, L; Hafidi, K; Hakobyan, H; Hanretty, C; Harrison, N; Hicks, K; Ho, D; Holtrop, M; Hyde, C E; Ilieva, Y; Ireland, D G; Ishkhanov, B S; Isupov, E L; Jo, H S; Joo, K; Keller, D; Khandaker, M; Kim, A; Kim, W; Klein, F J; Koirala, S; Kubarovsky, A; Kuleshov, S V; Kvaltine, N D; Lewis, S; Livingston, K; Lu, H Y; MacGregor, I J D; Mao, Y; Martinez, D; Mayer, M; McKinnon, B; Meyer, C A; Mineeva, T; Mirazita, M; Mokeev, V; Montgomery, R A; Moutarde, H; Munevar, E; Camacho, C Munoz; Nadel-Turonski, P; Nasseripour, R; Niccolai, S; Niculescu, G; Niculescu, I; Osipenko, M; Ostrovidov, A I; Pappalardo, L L; Paremuzyan, R; Park, K; Park, S; Pasyuk, E; Phelps, E; Phillips, J J; Pisano, S; Pogorelko, O; Pozdniakov, S; Price, J W; Procureur, S; Protopopescu, D; Puckett, A J R; Raue, B A; Ricco, G; Rimal, D; Ripani, M; Rosner, G; Rossi, P; Sabatié, F; Saini, M S; Salgado, C; Saylor, N A; Schott, D; Schumacher, R A; Seder, E; Seraydaryan, H; Sharabian, Y G; Smith, G D; Sober, D I; Sokhan, D; Stepanyan, S S; Stepanyan, S; Strakovsky, I I; Strauch, S; Taiuti, M; Tang, W; Taylor, C E; Tkachenko, S; Ungaro, M; Vernarsky, B; Voskanyan, H; Voutier, E; Walford, N K; Weinstein, L B; Weygand, D P; Wood, M H; Zachariou, N; Zhang, J; Zhao, Z W; Zonta, I

    2012-01-01

    We report the measurement of near threshold neutral pion electroproduction cross sections and the extraction of the associated structure functions on the proton in the kinematic range $Q^2$ from 2 to 4.5 GeV$^2$ and $W$ from 1.08 to 1.16 GeV. These measurements allow us to access the dominant pion-nucleon s-wave multipoles $E_{0+}$ and $S_{0+}$ in the near-threshold region. In the light-cone sum-rule framework (LCSR), these multipoles are related to the generalized form factors $G_1^{\\pi^0 p}(Q^2)$ and $G_2^{\\pi^0 p}(Q^2)$. The data are compared to these generalized form factors and the results for $G_1^{\\pi^0 p}(Q^2)$ are found to be in good agreement with the LCSR predictions, but the level of agreement with $G_2^{\\pi^0 p}(Q^2)$ is poor.

  3. Lifestyle factors and contact to general practice with respiratory alarm symptoms

    DEFF Research Database (Denmark)

    Sele, Lisa Maria Falk; Elnegaard, Sandra; Balasubramaniam, Kirubakaran

    2016-01-01

    BACKGROUND: A prerequisite for early lung cancer diagnosis is that individuals with respiratory alarm symptoms (RAS) contact a general practitioner (GP). This study aims to determine the proportion of individuals in the general population who contact a GP with RAS and to analyse the association...... between lifestyle factors and contact to GPs with RAS. METHODS: A web-based survey of 100 000 individuals randomly selected from the Danish Civil Registration System. Items regarding experience of RAS (prolonged coughing, shortness of breath, coughing up blood, and prolonged hoarseness), GP contacts......, and lifestyle factors (smoking status, alcohol intake, and body mass index) were included. RESULTS: In total 49 706 (52.5 %) individuals answered the questionnaire. Overall 7870 reported at least one respiratory alarm symptom, and of those 39.6 % (3 080) had contacted a GP. Regarding specific symptoms...

  4. Anxiety Sensitivity and Its Factors in Relation to Generalized Anxiety Disorder among Adolescents.

    Science.gov (United States)

    Knapp, Ashley A; Blumenthal, Heidemarie; Mischel, Emily R; Badour, Christal L; Leen-Feldner, Ellen W

    2016-02-01

    Anxiety psychopathology, one of the most prevalent classes of disorder among youth, is linked to detrimental outcomes. Accordingly, identifying factors that influence vulnerability to anxiety disorders is important. One promising factor, given emerging evidence for its transdiagnostic nature, is anxiety sensitivity (AS); however, relatively little is known about the linkage between AS and indicators of generalized anxiety disorder (GAD), particularly among youth. The aim of the current investigation was to address this gap in the literature using a community-based sample of adolescents aged 10-17 years (n = 165; M age  = 14.49 years, SD = 2.26). Results indicated global AS and the AS-physical concerns dimension were significantly associated with worry, generalized anxiety symptoms, and GAD diagnosis assessed via a structured clinical interview, above and beyond key theoretically-relevant covariates. These findings add to a growing body of work underscoring the relevance of AS for multiple types of anxiety-related disorders among youth.

  5. General formula for the incidence factor of a solar heliostat receiver system.

    Science.gov (United States)

    Wei, L Y

    1980-09-15

    A general formula is derived for the effective incidence factor of an array of heliostat mirrors for solar power collection. The formula can be greatly simplified for arrays of high symmetry and offers quick computation of the performance of the array. It shows clearly how the mirror distribution and locations affect the overall performance and thus provide a useful guidance for the design of a solar heliostat receiver system.

  6. Generalized Dynamic Factor Model + GARCH Exploiting Multivariate Information for Univariate Prediction

    OpenAIRE

    Alessi, Lucia; Barigozzi, Matteo; Capasso, Marco

    2006-01-01

    We propose a new model for multivariate forecasting which combines the Generalized Dynamic Factor Model (GDFM)and the GARCH model. The GDFM, applied to a huge number of series, captures the multivariate information and disentangles the common and the idiosyncratic part of each series of returns. In this financial analysis, both these components are modeled as a GARCH. We compare GDFM+GARCH and standard GARCH performance on samples up to 475 series, predicting both levels and volatility of ret...

  7. ASVCP quality assurance guidelines: control of general analytical factors in veterinary laboratories.

    Science.gov (United States)

    Flatland, Bente; Freeman, Kathy P; Friedrichs, Kristen R; Vap, Linda M; Getzy, Karen M; Evans, Ellen W; Harr, Kendal E

    2010-09-01

    Owing to lack of governmental regulation of veterinary laboratory performance, veterinarians ideally should demonstrate a commitment to self-monitoring and regulation of laboratory performance from within the profession. In response to member concerns about quality management in veterinary laboratories, the American Society for Veterinary Clinical Pathology (ASVCP) formed a Quality Assurance and Laboratory Standards (QAS) committee in 1996. This committee recently published updated and peer-reviewed Quality Assurance Guidelines on the ASVCP website. The Quality Assurance Guidelines are intended for use by veterinary diagnostic laboratories and veterinary research laboratories that are not covered by the US Food and Drug Administration Good Laboratory Practice standards (Code of Federal Regulations Title 21, Chapter 58). The guidelines have been divided into 3 reports on 1) general analytic factors for veterinary laboratory performance and comparisons, 2) hematology and hemostasis, and 3) clinical chemistry, endocrine assessment, and urinalysis. This report documents recommendations for control of general analytical factors within veterinary clinical laboratories and is based on section 2.1 (Analytical Factors Important In Veterinary Clinical Pathology, General) of the newly revised ASVCP QAS Guidelines. These guidelines are not intended to be all-inclusive; rather, they provide minimum guidelines for quality assurance and quality control for veterinary laboratory testing. It is hoped that these guidelines will provide a basis for laboratories to assess their current practices, determine areas for improvement, and guide continuing professional development and education efforts.

  8. Exploration of the Risk Factors of Generalized and Central Obesity among Adolescents in North Lebanon

    Directory of Open Access Journals (Sweden)

    Germine El-Kassas

    2017-01-01

    Full Text Available Adolescents’ obesity is an emerging public health problem globally and in the Arab countries. Alarming rates of overweight/obesity have been rising progressively in Lebanon. However, the risk factors for the development of adolescents’ obesity have not yet been thoroughly explored in North Lebanon. To determine the dietary and lifestyle risk factors associated with generalized and central obesity among adolescents living in Tripoli, a cross-sectional survey was conducted including a representative sample of 311 students aged 11–16 years from both sexes chosen from public and private schools in Tripoli. Data were collected using a standardized questionnaire to determine sociodemographic characteristics, dietary patterns, and physical activity and sedentary behaviors. Body mass index (BMI was evaluated using the Center for Disease Control BMI for age percentiles. Central obesity was assessed using both waist-to-height ratio and gender-specific waist circumference for age indices. Multiple logistic regression analysis revealed that skipping breakfast and physical inactivity were the most significant independent risk factors associated with both generalized and central obesity. In addition, higher screen time and male gender were associated with increased risk for generalized and central obesity, respectively. Intervention strategies to prevent the development of obesity should be implemented among adolescent students to encourage regular breakfast intake and adopting healthy dietary and lifestyle behaviors.

  9. General Moore-Penrose inverse of morphism with general factorization%具有广义分解的态射的广义Moore-Penrose逆

    Institute of Scientific and Technical Information of China (English)

    孙志敏

    2011-01-01

    研究了预加范畴中具有广义分解的态射的广义Moore—Penrose逆,并给出了广义Moore—Penrose逆存在的充要条件及其表达式.%This paper studies the general Moore-Penrose inverse of morphism with general factorization in a preadditive category, and gives some necessary and sufficient conditions for the existence and expressions of general Moore-Penrose inverse.

  10. Test Control Center exhibit

    Science.gov (United States)

    2000-01-01

    Have you ever wondered how the engineers at John C. Stennis Space Center in Hancock County, Miss., test fire a Space Shuttle Main Engine? The Test Control Center exhibit at StenniSphere can answer your questions by simulating the test firing of a Space Shuttle Main Engine. A recreation of one of NASA's test control centers, the exhibit explains and portrays the 'shake, rattle and roar' that happens during a real test firing.

  11. Conserved sequence motifs in the small subunit of human general transcription factor TFIIE.

    Science.gov (United States)

    Sumimoto, H; Ohkuma, Y; Sinn, E; Kato, H; Shimasaki, S; Horikoshi, M; Roeder, R G

    1991-12-05

    A general initiation factor, TFIIE, is essential for transcription initiation by RNA polymerase II in conjunction with other general factors. TFIIE is a heterotetramer containing two subunits of relative molecular mass 57,000 (TFIIE-alpha) and two of 34,000 (TFIIE-beta). TFIIE-beta is required in conjunction with TFIIE-alpha for transcription initiation. Here we report the cloning and expression of a complementary DNA encoding a functional human TFIIE-beta. Recombinant TFIIE-beta could replace the natural TFIIE-beta for transcription in conjunction with TFIIE-alpha. Amino-acid sequence comparisons reveal regions with sequence similarities to: subregion 3 of bacterial sigma factors; a region of RAP30 (the small subunit of TFIIF) with sequence similarity to a sigma-factor subregion implicated in binding to RNA polymerase; and a portion of the basic region-helix-loop-helix motif found in several enhancer-binding proteins. These potential homologies have implications for the role of TFIIE in preinitiation complex assembly and function.

  12. Prevalence of upper gastrointestinal bleeding risk factors among the general population and osteoarthritis patients.

    Science.gov (United States)

    Kim, Sang Hyuck; Yun, Jae Moon; Chang, Chong Bum; Piao, Heng; Yu, Su Jong; Shin, Dong Wook

    2016-12-28

    To assess the prevalence of possible risk factors of upper gastrointestinal bleeding (UGIB) and their age-group specific trend among the general population and osteoarthritis patients. We utilized data from the National Health Insurance Service that included claims data and results of the national health check-up program. Comorbid conditions (peptic ulcer, diabetes, liver disease, chronic renal failure, and gastroesophageal reflux disease), concomitant drugs (aspirin, clopidogrel, cilostazol, non-steroidal anti-inflammatory drugs, steroid, anticoagulants, and SSRI), personal habits (smoking, and alcohol consumption) were considered as possible UGIB risk factors. We randomly imputed the prevalence of infection in the data considering the age-specific prevalence of Helicobacter pylori (H. pylori) infection in Korea. The prevalence of various UGIB risk factors and the age-group specific trend of the prevalence were identified. Prevalence was compared between osteoarthritis patients and others. A total of 801926 subjects (93855 osteoarthritis patients) aged 20 and above were included. The prevalence of individual and concurrent multiple risk factors became higher as the age increased. The prevalence of each comorbid condition and concomitant drug were higher in osteoarthritis patients. Thirty-five point zero two percent of the overall population and 68.50% of osteoarthritis patients had at least one or more risk factors of UGIB. The prevalence of individual and concurrent multiple risk factors in younger age groups were also substantial. Furthermore, when personal habits (smoking, and alcohol consumption) and H. pylori infection were included, the prevalence of concurrent multiple risk factors increased greatly even in younger age groups. Prevalence of UGIB risk factors was high in elderly population, but was also considerable in younger population. Patient with osteoarthritis was at higher UGIB risk than those without osteoarthritis. Physicians should consider

  13. Prevalence of upper gastrointestinal bleeding risk factors among the general population and osteoarthritis patients

    Science.gov (United States)

    Kim, Sang Hyuck; Yun, Jae Moon; Chang, Chong Bum; Piao, Heng; Yu, Su Jong; Shin, Dong Wook

    2016-01-01

    AIM To assess the prevalence of possible risk factors of upper gastrointestinal bleeding (UGIB) and their age-group specific trend among the general population and osteoarthritis patients. METHODS We utilized data from the National Health Insurance Service that included claims data and results of the national health check-up program. Comorbid conditions (peptic ulcer, diabetes, liver disease, chronic renal failure, and gastroesophageal reflux disease), concomitant drugs (aspirin, clopidogrel, cilostazol, non-steroidal anti-inflammatory drugs, steroid, anticoagulants, and SSRI), personal habits (smoking, and alcohol consumption) were considered as possible UGIB risk factors. We randomly imputed the prevalence of infection in the data considering the age-specific prevalence of Helicobacter pylori (H. pylori) infection in Korea. The prevalence of various UGIB risk factors and the age-group specific trend of the prevalence were identified. Prevalence was compared between osteoarthritis patients and others. RESULTS A total of 801926 subjects (93855 osteoarthritis patients) aged 20 and above were included. The prevalence of individual and concurrent multiple risk factors became higher as the age increased. The prevalence of each comorbid condition and concomitant drug were higher in osteoarthritis patients. Thirty-five point zero two percent of the overall population and 68.50% of osteoarthritis patients had at least one or more risk factors of UGIB. The prevalence of individual and concurrent multiple risk factors in younger age groups were also substantial. Furthermore, when personal habits (smoking, and alcohol consumption) and H. pylori infection were included, the prevalence of concurrent multiple risk factors increased greatly even in younger age groups. CONCLUSION Prevalence of UGIB risk factors was high in elderly population, but was also considerable in younger population. Patient with osteoarthritis was at higher UGIB risk than those without osteoarthritis

  14. Factors related to doctors' choice of rural pathway in general practice specialty training.

    Science.gov (United States)

    Sureshkumar, Premala; Roberts, Chris; Clark, Tyler; Jones, Michael; Hale, Robert; Grant, Marcia

    2017-06-01

    To investigate the factors eligible applicants consider in electing for a rural pathway into specialty training. Cohort study. Australia. Applicants to the Australian General Practice Training program. Applicants' initial preference of either a general or rural pathway to undertake specialty training. Of the 2,221 applicants, 45% were Australian Medical Graduates (AMGs), 27% Foreign Graduates of Accredited Medical Schools (FGAMS) and 29% International Medical Graduates (IMGs). Through government regulation, two thirds (70%) were eligible to train on both general and rural pathways and a third (30%) were required to train rurally. For applicants eligible for general pathway (n = 1552), those with rural background [Odds Ratio (OR) = 3.7, 95% CI 2.7-5.2] and rural clinical school experience (OR = 2.0, 95% CI 1.5-2.8) were more likely to choose the rural pathway. In addition, FGAMS who were eligible for the general pathway were less likely to choose a rural pathway when compared with IMGs (OR = 0.33, 95%CI 0.1 = 0.7). In applicants who changed their training pathway from their initial to revised preference, lower Multiple-Mini-Interview (OR = 0.54, 95% CI 0.43-0.66) and Situational Judgement Test z-scores (OR = 0.68, 95% CI 0.56-0.83) were associated with a higher probability of changing from a general to rural pathway preference. For those eligible for a general or rural pathway, rural background and rural clinical school experience are associated with the decision to elect for rural training. Targeted support for international and foreign graduates of Australia/New Zealand schools may influence them to train rurally. © 2016 National Rural Health Alliance Inc.

  15. Coming to Terms With Risk Factors for Eating Disorders: Application of Risk Terminology and Suggestions for a General Taxonomy

    Science.gov (United States)

    Jacobi, Corinna; Hayward, Chris; de Zwaan, Martina; Kraemer, Helena C.; Agras, W. Steward

    2004-01-01

    The aims of the present review are to apply a recent risk factor approach (H. C. Kraemer et al., 1997) to putative risk factors for eating disorders, to order these along a timeline, and to deduce general taxonomic questions. Putative risk factors were classified according to risk factor type, outcome (anorexia nervosa, bulimia nervosa,…

  16. EXHIBITION: Accelerated Particles

    CERN Multimedia

    2004-01-01

    An exhibition of plastic arts and two evenings of performances by sound and visual artists as part of CERN's 50th anniversary celebrations. Fifty candles for CERN, an international laboratory renowned for fundamental research, is a cause for celebration. Since March this year, Geneva and neighbouring parts of France have been the venues for a wealth of small and large-scale events, which will continue until November. Given CERN's location in the commune of Meyrin, the ForuMeyrin is hosting exhibitions of plastic arts and performances entitled: Accelerated Particles. Several works will be exhibited and performed in two 'salons'. Salon des matières: An exhibition of plastic arts From Tues 12 October to Wed 3 November 2004 Tuesdays to Fridays: 16:00 to 19:00 Saturdays: 14:00 to 18:00 Exhibition open late on performance nights, entrance free Salon des particules: Musical and visual performances Tues 12 and Mon 25 October from 20:00 to 23:00 Preview evening for both events: Tues 12 October from 18:...

  17. Council Chamber exhibition

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    To complete the revamp of CERN’s Council Chamber, a new exhibition is being installed just in time for the June Council meetings.   Panels will showcase highlights of CERN’s history, using some of the content prepared for the exhibitions marking 50 years of the PS, which were displayed in the main building last November. The previous photo exhibition in the Council Chamber stopped at the 1970s. To avoid the new panels becoming quickly out of date, photos are grouped together around specific infrastructures, rather than following a classic time-line. “We have put the focus on the accelerators – the world-class facilities that CERN has been offering researchers over the years, from the well-known large colliders to the lesser-known smaller facilities,” says Emma Sanders, who worked on the content. The new exhibition will be featured in a future issue of the Bulletin with photos and an interview with Fabienne Marcastel, designer of the exhibit...

  18. Human Umbilical Cord Perivascular Cells Exhibited Enhanced Migration Capacity towards Hepatocellular Carcinoma in Comparison with Bone Marrow Mesenchymal Stromal Cells: A Role for Autocrine Motility Factor Receptor

    Directory of Open Access Journals (Sweden)

    Juan Bayo

    2014-01-01

    Full Text Available Hepatocellular carcinoma (HCC is the third cause of cancer-related death worldwide. Unfortunately, the incidence and mortality associated with HCC are increasing. Therefore, new therapeutic strategies are urgently needed and the use of mesenchymal stromal cells (MSCs as carrier of therapeutic genes is emerging as a promising option. Different sources of MSCs are being studied for cell therapy and bone marrow-derived cells are the most extensively explored; however, birth associated-tissues represent a very promising source. The aim of this work was to compare the in vitro and in vivo migration capacity between bone marrow MSCs (BM-MSCs and human umbilical cord perivascular cells (HUCPVCs towards HCC. We observed that HUCPVCs presented higher in vitro and in vivo migration towards factors released by HCC. The expression of autocrine motility factor (AMF receptor, genes related with the availability of the receptor on the cell surface (caveolin-1 and -2 and metalloproteinase 3, induced by the receptor activation and important for cell migration, was increased in HUCPVCs. The chemotactic response towards recombinant AMF was increased in HUCPVCs compared to BM-MSCs, and its inhibition in the conditioned medium from HCC induced higher decrease in HUCPVC migration than in BM-MSC. Our results indicate that HUCPVCs could be a useful cellular source to deliver therapeutic genes to HCC.

  19. Risk factors for coronary atherosclerosis in a general Japanese population: the Hisayama study.

    Science.gov (United States)

    Nakashima, Yutaka; Kiyohara, Yutaka; Doi, Yasufumi; Kubo, Michiaki; Iida, Mitsuo; Sueishi, Katsuo

    2009-01-01

    To investigate risk factors for coronary atherosclerosis in men and women in the recent general Japanese population, we examined coronary arteries obtained from subjects autopsied in the Hisayama cohort study (autopsy rate: 78.7%). The subjects were over 40 years of age and consisted of 125 men and 108 women. They underwent an antemortem medical examination in 1988 and were subject to autopsy at death during an 8-year follow-up period. Atherosclerosis was globally assessed by examining 14 specimens taken from wide areas of epicardial coronary arteries and classified into 6 grades. The frequency of more severe grades of coronary atherosclerosis increased with age in both genders and was greater in men than in women of the same age. Multiple regression analysis revealed that age, systolic blood pressure, serum total cholesterol, and hemoglobin A(1C) were significant risk factors for men. Age, systolic blood pressure, and waist to hip ratio were risk factors for women. Smoking was not significantly correlated with the grade of coronary atherosclerosis in either gender. Thus, aging, hypertension, hypercholesterolemia, obesity, and glucose intolerance are risk factors for coronary atherosclerosis in recent Japanese populations, and the significance of the metabolic risk factors is different between men and women.

  20. Structure factors for tunneling ionization rates of molecules: General Hartree-Fock-based integral representation

    Science.gov (United States)

    Madsen, Lars Bojer; Jensen, Frank; Dnestryan, Andrey I.; Tolstikhin, Oleg I.

    2017-07-01

    In the leading-order approximation of the weak-field asymptotic theory (WFAT), the dependence of the tunneling ionization rate of a molecule in an electric field on its orientation with respect to the field is determined by the structure factor of the ionizing molecular orbital. The WFAT yields an expression for the structure factor in terms of a local property of the orbital in the asymptotic region. However, in general quantum chemistry approaches molecular orbitals are expanded in a Gaussian basis which does not reproduce their asymptotic behavior correctly. This hinders the application of the WFAT to polyatomic molecules, which are attracting increasing interest in strong-field physics. Recently, an integral-equation approach to the WFAT for tunneling ionization of one electron from an arbitrary potential has been developed. The structure factor is expressed in an integral form as a matrix element involving the ionizing orbital. The integral is not sensitive to the asymptotic behavior of the orbital, which resolves the difficulty mentioned above. Here, we extend the integral representation for the structure factor to many-electron systems treated within the Hartree-Fock method and show how it can be implemented on the basis of standard quantum chemistry software packages. We validate the methodology by considering noble-gas atoms and the CO molecule, for which accurate structure factors exist in the literature. We also present benchmark results for CO2 and for NH3 in the pyramidal and planar geometries.

  1. On the factor structure of the Rosenberg (1965) General Self-Esteem Scale.

    Science.gov (United States)

    Alessandri, Guido; Vecchione, Michele; Eisenberg, Nancy; Łaguna, Mariola

    2015-06-01

    Since its introduction, the Rosenberg General Self-Esteem Scale (RGSE, Rosenberg, 1965) has been 1 of the most widely used measures of global self-esteem. We conducted 4 studies to investigate (a) the goodness-of-fit of a bifactor model positing a general self-esteem (GSE) factor and 2 specific factors grouping positive (MFP) and negative items (MFN) and (b) different kinds of validity of the GSE, MFN, and MFP factors of the RSGE. In the first study (n = 11,028), the fit of the bifactor model was compared with those of 9 alternative models proposed in literature for the RGSE. In Study 2 (n = 357), the external validities of GSE, MFP, and MFN were evaluated using objective grade point average data and multimethod measures of prosociality, aggression, and depression. In Study 3 (n = 565), the across-rater robustness of the bifactor model was evaluated. In Study 4, measurement invariance of the RGSE was further supported across samples in 3 European countries, Serbia (n = 1,010), Poland (n = 699), and Italy (n = 707), and in the United States (n = 1,192). All in all, psychometric findings corroborate the value and the robustness of the bifactor structure and its substantive interpretation. (c) 2015 APA, all rights reserved).

  2. Unusual armadillo fold in the human general vesicular transport factor p115.

    Directory of Open Access Journals (Sweden)

    Harald Striegl

    Full Text Available The golgin family gives identity and structure to the Golgi apparatus and is part of a complex protein network at the Golgi membrane. The golgin p115 is targeted by the GTPase Rab1a, contains a large globular head region and a long region of coiled-coil which forms an extended rod-like structure. p115 serves as vesicle tethering factor and plays an important role at different steps of vesicular transport. Here we present the 2.2 A-resolution X-ray structure of the globular head region of p115. The structure exhibits an armadillo fold that is decorated by elongated loops and carries a C-terminal non-canonical repeat. This terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering.

  3. Attitudes, norms and controls influencing lifestyle risk factor management in general practice.

    Science.gov (United States)

    Ampt, Amanda J; Amoroso, Cheryl; Harris, Mark F; McKenzie, Suzanne H; Rose, Vanessa K; Taggart, Jane R

    2009-08-26

    With increasing rates of chronic disease associated with lifestyle behavioural risk factors, there is urgent need for intervention strategies in primary health care. Currently there is a gap in the knowledge of factors that influence the delivery of preventive strategies by General Practitioners (GPs) around interventions for smoking, nutrition, alcohol consumption and physical activity (SNAP). This qualitative study explores the delivery of lifestyle behavioural risk factor screening and management by GPs within a 45-49 year old health check consultation. The aims of this research are to identify the influences affecting GPs' choosing to screen and choosing to manage SNAP lifestyle risk factors, as well as identify influences on screening and management when multiple SNAP factors exist. A total of 29 audio-taped interviews were conducted with 15 GPs and one practice nurse over two stages. Transcripts from the interviews were thematically analysed, and a model of influencing factors on preventive care behaviour was developed using the Theory of Planned Behaviour as a structural framework. GPs felt that assessing smoking status was straightforward, however some found assessing alcohol intake only possible during a formal health check. Diet and physical activity were often inferred from appearance, only being assessed if the patient was overweight. The frequency and thoroughness of assessment were influenced by the GPs' personal interests and perceived congruence with their role, the level of risk to the patient, the capacity of the practice and availability of time. All GPs considered advising and educating patients part of their professional responsibility. However their attempts to motivate patients were influenced by perceptions of their own effectiveness, with smoking causing the most frustration. Active follow-up and referral of patients appeared to depend on the GPs' orientation to preventive care, the patient's motivation, and cost and accessibility of

  4. Attitudes, norms and controls influencing lifestyle risk factor management in general practice

    Directory of Open Access Journals (Sweden)

    McKenzie Suzanne H

    2009-08-01

    Full Text Available Abstract Background With increasing rates of chronic disease associated with lifestyle behavioural risk factors, there is urgent need for intervention strategies in primary health care. Currently there is a gap in the knowledge of factors that influence the delivery of preventive strategies by General Practitioners (GPs around interventions for smoking, nutrition, alcohol consumption and physical activity (SNAP. This qualitative study explores the delivery of lifestyle behavioural risk factor screening and management by GPs within a 45–49 year old health check consultation. The aims of this research are to identify the influences affecting GPs' choosing to screen and choosing to manage SNAP lifestyle risk factors, as well as identify influences on screening and management when multiple SNAP factors exist. Methods A total of 29 audio-taped interviews were conducted with 15 GPs and one practice nurse over two stages. Transcripts from the interviews were thematically analysed, and a model of influencing factors on preventive care behaviour was developed using the Theory of Planned Behaviour as a structural framework. Results GPs felt that assessing smoking status was straightforward, however some found assessing alcohol intake only possible during a formal health check. Diet and physical activity were often inferred from appearance, only being assessed if the patient was overweight. The frequency and thoroughness of assessment were influenced by the GPs' personal interests and perceived congruence with their role, the level of risk to the patient, the capacity of the practice and availability of time. All GPs considered advising and educating patients part of their professional responsibility. However their attempts to motivate patients were influenced by perceptions of their own effectiveness, with smoking causing the most frustration. Active follow-up and referral of patients appeared to depend on the GPs' orientation to preventive care, the

  5. Factors affecting collaboration between general practitioners and community pharmacists: a qualitative study

    Directory of Open Access Journals (Sweden)

    Rubio-Valera Maria

    2012-07-01

    Full Text Available Abstract Background Although general practitioners (GPs and community pharmacists (CPs are encouraged to collaborate, a true collaborative relationship does not exist between them. Our objective was to identify and analyze factors affecting GP-CP collaboration. Methods This was a descriptive-exploratory qualitative study carried out in two Spanish regions: Catalonia (Barcelona and Balearic Islands (Mallorca. Face-to-face semi-structured interviews were conducted with GPs and CPs from Barcelona and Mallorca (January 2010-February 2011. Analysis was conducted using Colaizzi’s method. Results Thirty-seven interviews were conducted. The factors affecting the relationship were different depending on timing: 1 Before collaboration had started (prior to collaboration and 2 Once the collaboration had been initiated (during collaboration. Prior to collaboration, four key factors were found to affect it: the perception of usefulness; the Primary Care Health Center (PCHC manager’s interest; the professionals’ attitude; and geography and legislation. These factors were affected by economic and organizational aspects (i.e. resources or PCHC management styles and by professionals’ opinions and beliefs (i.e. perception of the existence of a public-private conflict. During collaboration, the achievement of objectives and the changes in the PCHC management were the key factors influencing continued collaboration. The most relevant differences between regions were due to the existence of privately-managed PCHCs in Barcelona that facilitated the implementation of collaboration. In comparison with the group with experience in collaboration, some professionals without experience reported a skeptical attitude towards it, reporting that it might not be necessary. Conclusions Factors related to economic issues, management and practitioners’ attitudes and perceptions might be crucial for triggering collaboration. Interventions and strategies derived from these

  6. A single chain variant of factor VIII Fc fusion protein retains normal in vivo efficacy but exhibits altered in vitro activity.

    Directory of Open Access Journals (Sweden)

    Yang Buyue

    Full Text Available Recombinant factor VIII Fc (rFVIIIFc is a fusion protein consisting of a single B-domain-deleted (BDD FVIII linked recombinantly to the Fc domain of human IgG1 to extend half-life. To determine if rFVIIIFc could be further improved by maintaining the heavy and light chains within a contiguous single chain (SC, we evaluated the activity and function of SC rFVIIIFc, an isoform that is not processed at residue R1648. SC rFVIIIFc showed equivalent activity in a chromogenic assay compared to rFVIIIFc, but approximately 40% activity by the one-stage clotting assay in the presence of von Willebrand Factor (VWF, with full activity in the absence of VWF. Moreover, SC rFVIIIFc demonstrated markedly delayed thrombin-mediated release from VWF, but an activity similar to that of rFVIIIFc upon activation in FXa generation assays. Therefore, the apparent reduction in specific activity in the aPTT assay appears to be primarily due to delayed release of FVIII from VWF. To assess whether stability and activity of SC rFVIIIFc were affected in vivo, a tail vein transection model in Hemophilia A mice was utilized. The results demonstrated similar pharmacokinetic profiles and comparable efficacy for SC rFVIIIFc and rFVIIIFc. Thus, while the single chain configuration did not promote enhanced half-life, it reduced the rate of release of FVIII from VWF required for activation. This impaired release may underlie the observed reduction in the one-stage clotting assay, but does not appear to affect the physiological activity of SC rFVIIIFc.

  7. Lifestyle factors and experience of respiratory alarm symptoms in the general population

    DEFF Research Database (Denmark)

    Sele, Lisa Maria Falk; Balasubramaniam, Kirubakaran; Elnegaard, Sandra

    2015-01-01

    BACKGROUND: The first step in the diagnosis of lung cancer is for individuals in the general population to recognise respiratory alarm symptoms (RAS). Knowledge is sparse about RAS and factors associated with experiencing RAS in the general population. This study aimed to estimate the prevalence......: ORmen=1.42, 95% CI 1.39 to 1.56; ORwomen=1.25, 95% CI 1.15 to 1.36; current smoking: ORmen=2.58, 95% CI 2.35 to 2.83; ORwomen=2.45, 95% CI 2.25 to 2.68). Individuals who were underweight or obese were significantly more likely to report at least one RAS. Odds of reporting at least one RAS increased...... with increasing alcohol intake for both genders (Ptrendobese are positively associated with experiencing RAS...

  8. Fatigue in the Danish general population. Influence of sociodemographic factors and disease

    DEFF Research Database (Denmark)

    Watt, T; Groenvold, M; Bjorner, J B;

    2000-01-01

    -77 with an equal gender distribution (response rate 67%). MAIN OUTCOME MEASURES: Five fatigue scales from the questionnaire Multidimensional Fatigue Inventory: General Fatigue, Physical Fatigue, Reduced Activity, Reduced Motivation and Mental Fatigue. RESULTS: Fatigue scores were skewed towards absence of fatigue...... showed that respondents of low social status and respondents with a depression had high fatigue scores on all scales, independent of other factors. Chronic somatic disease had an independent direct effect on Mental Fatigue, but for the rest of the scales, the effect of somatic disease depended on age......, gender and/or whether the person was living alone. For example, General and Physical Fatigue decreased with age among healthy people, whereas scores on these scales increased with age among those with a somatic disease. CONCLUSIONS: Physical and mental diseases play essential parts for the level...

  9. A general pairwise interaction model provides an accurate description of in vivo transcription factor binding sites.

    Directory of Open Access Journals (Sweden)

    Marc Santolini

    Full Text Available The identification of transcription factor binding sites (TFBSs on genomic DNA is of crucial importance for understanding and predicting regulatory elements in gene networks. TFBS motifs are commonly described by Position Weight Matrices (PWMs, in which each DNA base pair contributes independently to the transcription factor (TF binding. However, this description ignores correlations between nucleotides at different positions, and is generally inaccurate: analysing fly and mouse in vivo ChIPseq data, we show that in most cases the PWM model fails to reproduce the observed statistics of TFBSs. To overcome this issue, we introduce the pairwise interaction model (PIM, a generalization of the PWM model. The model is based on the principle of maximum entropy and explicitly describes pairwise correlations between nucleotides at different positions, while being otherwise as unconstrained as possible. It is mathematically equivalent to considering a TF-DNA binding energy that depends additively on each nucleotide identity at all positions in the TFBS, like the PWM model, but also additively on pairs of nucleotides. We find that the PIM significantly improves over the PWM model, and even provides an optimal description of TFBS statistics within statistical noise. The PIM generalizes previous approaches to interdependent positions: it accounts for co-variation of two or more base pairs, and predicts secondary motifs, while outperforming multiple-motif models consisting of mixtures of PWMs. We analyse the structure of pairwise interactions between nucleotides, and find that they are sparse and dominantly located between consecutive base pairs in the flanking region of TFBS. Nonetheless, interactions between pairs of non-consecutive nucleotides are found to play a significant role in the obtained accurate description of TFBS statistics. The PIM is computationally tractable, and provides a general framework that should be useful for describing and predicting

  10. Factors that influence delivery of tobacco cessation support in general dental practice: a narrative review.

    Science.gov (United States)

    Lala, Rizwana; Csikar, Julia; Douglas, Gail; Muarry, Jenni

    2017-12-01

    To review the literature reporting factors that are associated with the delivery of lifestyle support in general dental practice. A systematic review of the quantitative observational studies describing activities to promote the general health of adults in primary care general dental practice. Behavior change included tobacco cessation, alcohol reduction, diet, weight management, and physical activity. Tooth brushing and oral hygiene behaviors were excluded as the focus of this review was on the common risk factors that affect general health as well as oral health. Six cross sectional studies met the inclusion criteria. Five studies only reported activities to support tobacco cessation. As well as tobacco cessation one study also reported activities related to alcohol usage, physical activity, and Body Mass Index. Perceptions of time availability consistently correlated with activities and beliefs about tobacco cessation, alongside the smoking status of the dental professional. Dentists who perceive having more available time were more likely to discuss smoking with patients, prescribe smoking cessation treatments and direct patients toward (signpost to) lifestyle support services. Dental professionals who smoke were less likely to give smoking cessation advice and counselling than nonsmokers. Finally, the data showed that professional support may be relevant. Professionals who work in solo practices or those who felt a lack of support from the wider professional team (peer support) were more likely to report barriers to delivering lifestyle support. Organizational changes in dental practices to encourage more team working and professional time for lifestyle support may influence delivery. Dental professionals who are smokers may require training to develop their beliefs about the effectiveness of smoking cessation interventions. © 2016 American Association of Public Health Dentistry.

  11. Exhibition in Sight

    Science.gov (United States)

    Wasserman, Burton

    1978-01-01

    Ludwig Mies van der Rohe is known primarily as an architect. However, he also designed chairs and tables. Discusses an exhibit held in New York City a few months ago which showed how well the famous architect achieved his goals in the area of furniture design. (Author/RK)

  12. Exhibitions in Sight

    Science.gov (United States)

    Wasserman, Burton

    1977-01-01

    Today, few artists make serving vessels on a monumental scale. Here artists compete in this unique area of specialization prompted by the Campbell Museum in Camden, New Jersey, which is dedicated to collecting and exhibiting the very best in soup tureens. (Author/RK)

  13. EXHIBITION: Accelerated Particles

    CERN Multimedia

    2004-01-01

    http://www.cern.ch/cern50/ An exhibition of plastic arts and two evenings of performances by sound and visual artists as part of CERN's fiftieth anniversary celebrations. The fiftieth anniversary of a world famous organization like CERN, an international laboratory specializing in fundamental research, is a cause for celebration. Since March this year, Geneva and neighbouring parts of France have been the venues for a wealth of small and large-scale events, which will continue until November. Given CERN's location in the commune of Meyrin, the ForuMeyrin is hosting two "salons" consisting of an exhibition of plastic arts and evenings of music and visual arts performances with the collective title of "Accelerated Particles". Several works will be exhibited and performed. Salon des matières: An exhibition of plastic arts Until Wednesday 3 November 2004. Tuesdays to Fridays: 4.00 p.m. to 7.00 p.m. Saturdays: 2.00 p.m. to 6.00 p.m. Doors open late on the evening of the performances. Salon des ...

  14. Study of Confinement/Deconfinement Transition in AdS/QCD with Generalized Warp Factors

    Directory of Open Access Journals (Sweden)

    Shobhit Sachan

    2014-01-01

    Full Text Available We study analytical solutions of charged black holes and thermally charged AdS with generalized warped factors in Einstein-Maxwell-Dilaton system. We calculate Euclidean action for charged AdS and thermally charged AdS. The actions in both backgrounds are regularized by the method of background subtraction. The study of phase transition between charged black hole and thermally charged AdS gives an insight into the confinement/deconfinement transition. The plots of grand potential versus temperature and chemical potential versus transition temperature are obtained.

  15. Mammographic texture resemblance generalizes as an independent risk factor for breast cancer

    DEFF Research Database (Denmark)

    Nielsen, Mads; Vachon, Celine M.; Scott, Christopher G.;

    2014-01-01

    density. We examine if these findings generalize to another population.METHODS:Texture patterns were recorded in digitalized pre-diagnosis (3.7years) film mammograms of a nested case-control study within the Dutch screening program (S1) comprising of 245 breast cancers and 250 matched controls...... and continuously for association with breast cancer using odds ratios (OR) and adjusting for known risk factors including age, body mass index (BMI), and hormone usage.RESULTS:The mean ages of S1 and S2 were 58.0+/-5.7years and 55.2+/-10.5years, respectively. The MTR scores on S1 showed significant capability...

  16. Factores asociados a insulinemia en población general adolescente

    OpenAIRE

    Rafael Galera Martínez; Emilio García García; M.ª Ángeles Vázquez López; María Ortiz Pérez; Encarnación López Ruzafa; Manuel Martín González; Pablo Garrido Fernández; Antonio Bonillo Perales

    2013-01-01

    Objetivo: Analizar los factores asociados con insulinemia en ayunas en población general adolescente. Métodos: Estudio epidemiológico observacional sobre una muestra poblacional de adolescentes (12-16,9 años) seleccionados mediante muestreo probabilístico polietápico. Se realizaron examen físico, antropometría, encuesta nutricional y se determinó insulinemia en ayunas. Estadística: regresión lineal múltiple. Resultados: Se incluyeron 379 adolescentes con edad media 14,08 ± 1,30 años. Se relac...

  17. Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo.

    Directory of Open Access Journals (Sweden)

    Yong-Qing Liu

    Full Text Available Previously, we reported that retigeric acid B (RB, a natural pentacyclic triterpenic acid isolated from lichen, inhibited cell growth and induced apoptosis in androgen-independent prostate cancer (PCa cells. However, the mechanism of action of RB remains unclear. In this study, we found that using PC3 and DU145 cells as models, RB inhibited phosphorylation levels of IκBα and p65 subunit of NF-κB in a time- and dosage-dependent manner. Detailed study revealed that RB blocked the nuclear translocation of p65 and its DNA binding activity, which correlated with suppression of NF-κB-regulated proteins including Bcl-2, Bcl-x(L, cyclin D1 and survivin. NF-κB reporter assay suggested that RB was able to inhibit both constitutive activated-NF-κB and LPS (lipopolysaccharide-induced activation of NF-κB. Overexpression of RelA/p65 rescued RB-induced cell death, while knockdown of RelA/p65 significantly promoted RB-mediated inhibitory effect on cell proliferation, suggesting the crucial involvement of NF-κB pathway in this event. We further analyzed antitumor activity of RB in in vivo study. In C57BL/6 mice carrying RM-1 homografts, RB inhibited tumor growth and triggered apoptosis mainly through suppressing NF-κB activity in tumor tissues. Additionally, DNA microarray data revealed global changes in the gene expression associated with cell proliferation, apoptosis, invasion and metastasis in response to RB treatment. Therefore, our findings suggested that RB exerted its anti-tumor effect by targeting the NF-κB pathway in PCa cells, and this could be a general mechanism for the anti-tumor effect of RB in other types of cancers as well.

  18. Anti-vascular endothelial growth factor antibody single therapy for pancreatic neuroendocrine carcinoma exhibits a marked tumor growth-inhibitory effect.

    Science.gov (United States)

    Kasuya, Kazuhiko; Nagakawa, Yuichi; Suzuki, Minako; Tanaka, Hiroaki; Ohta, Hiroshi; Itoi, Takao; Tsuchida, Akihiko

    2011-11-01

    At present, no effective chemotherapy for pancreatic neuroendocrine carcinoma (PNEC) exists. However, anti-angiogenic therapy is expected to be effective for PNEC, a hypervascular tumor. We treated PNEC and hypovascular pancreatic ductal cell carcinoma (DCC) cell lines with the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab, and compared the antitumor effect between the two different types of cell lines. The PNEC cell line QGP-1 and the DCC cell lines BxPC-3 and AsPC-1 were used. We evaluated the ability of the cell lines to proliferate and secrete VEGF in vitro, the antitumor effect of bevacizumab administration in vivo and the side effects of bevacizumab on the pancreas in a caerulein-induced pancreatitis model. Comparison of the QGP-1 and DCC cell lines showed that QGP-1 secreted a higher level of VEGF under a hypoxic environment than the DCC cell line, and bevacizumab exerted the most marked growth-inhibitory effect on QGP-1; the number of intratumoral blood vessels decreased and the percentage of proliferating cells was approximately the same. In the pancreatitis model, bevacizumab administration did not adversely affect the pancreatitis or the associated hypoxic environment. Bevacizumab does not affect the pancreas itself; therefore, its potent inhibitory effect on the growth of pancreatic neuroendocrine tumors alone can be expected.

  19. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB.

    Science.gov (United States)

    Checker, Rahul; Patwardhan, Raghavendra S; Sharma, Deepak; Menon, Jisha; Thoh, Maikho; Bhilwade, Hari N; Konishi, Tetsuya; Sandur, Santosh K

    2012-10-01

    Schisandrin B (SB), a dibenzocyclooctadiene derivative isolated from Schisandra chinensis and used commonly in traditional Chinese medicine for the treatment of hepatitis and myocardial disorders, has been recently shown to modulate cellular redox balance. Since we have shown that cellular redox plays an important role in the modulation of immune responses, the present studies were undertaken to study the effects of SB on activation and effector functions of lymphocytes. SB altered the redox status of lymphocytes by enhancing the basal reactive oxygen species levels and altering the GSH/GSSG ratio in lymphocytes. It also induced nuclear translocation of redox sensitive transcription factor Nrf2 and increased the transcription of its dependent genes. SB inhibited mitogen-induced proliferation and cytokine secretion by lymphocytes. SB also significantly inhibited mitogen-induced upregulation of T cell costimulatory molecules and activation markers. It was observed that SB inhibited mitogen-induced phosphorylation of c-Raf, MEK, ERK, JNK, and p38. It suppressed IκBα degradation and nuclear translocation of NF-κB in activated lymphocytes. Anti-inflammatory effects of SB were significantly abrogated by the inhibitors of Nrf2 and HO-1, suggesting the involvement of this pathway. Similar anti-inflammatory effects of SB on lymphocyte proliferation and cytokine secretion were also observed in vivo. To our knowledge, this is the first report showing that the anti-inflammatory effects of SB are mediated via modulation of Nrf2 and NF-κB in lymphocytes.

  20. Drell-Yan process with jet vetoes: breaking of generalized factorization

    Science.gov (United States)

    Zeng, Mao

    2015-10-01

    Resummation of hadron collision cross sections, when the measurement imposes a hierarchy of scales, relies on factorization. Cancellation of Glauber/Coulomb gluons is a necessary condition for factorization. For Drell-Yan-like processes, the known proofs of cancellation of Glauber gluons are not applicable when jet vetoes are introduced, via jet algorithms or event shape variables such as the beam thrust. A priori, this does not rule out the possibility that an unknown new cancellation mechanism exists, or the possibility that a generalized factorization formalism is correct. To resolve the questions, we construct a direct counter-example in QCD with scalar quarks, contradicting any form of factorization in which the two collinear sectors are decoupled from each other. In the counter-example, decoupling of the two collinear sectors implies zero dependence of the beam thrust distribution on the longitudinal spin of the incoming hadrons, but we find a non-zero spin asymmetry at leading power due to Glauber gluons exchanged between spectators. We discuss implications for resumming large logarithms from jet vetoes.

  1. User's manual for CNVUFAC, the general dynamics heat-transfer radiation view factor program

    Energy Technology Data Exchange (ETDEWEB)

    Wong, R. L.

    1976-06-25

    CNVUFAC, the General Dynamics heat-transfer radiation veiw factor program, has been adapted for use on the LLL CDC 7600 computer system. The input and output have been modified, and a node incrementing logic was included to make the code compatible with the TRUMP thermal analyzer and related codes. The program performs the multiple integration necessary to evaluate the geometric black-body radiaton node to node view factors. Card image output that contains node number and view factor information is generated for input into the related program GRAY. Program GRAY is then used to include the effects of gray-body emissivities and multiple reflections, generating the effective gray-body view factors usable in TRUMP. CNVUFAC uses an elemental area summation scheme to evaluate the multiple integrals. The program permits shadowing and self-shadowing. The basic configuration shapes that can be considered are cylinders, cones, spheres, ellipsoids, flat plates, disks, toroids, and polynomials of revolution. Portions of these shapes can also be considered.

  2. Two grass carp (Ctenopharyngodon idella) insulin-like growth factor-binding protein 5 genes exhibit different yet conserved functions in development and growth.

    Science.gov (United States)

    Zheng, Guo-Dong; Zhou, Chun-Xue; Lin, Si-Tong; Chen, Jie; Jiang, Xia-Yun; Zou, Shu-Ming

    2017-02-01

    Insulin-like growth factor binding-protein 5 (igfbp5), the most conserved member of the IGFBP family in vertebrates, plays a critical role in controlling cell survival, growth, differentiation, and apoptosis. Here, we characterized the expression patterns of igfbp5a and igfbp5b in grass carp (Ctenopharyngodon idella), which are retained in many fish species, likely from the teleost-specific whole-genome duplication. Both igfbp5a and igfbp5b encode 268- and 263-aa peptides, respectively, which share a sequence identity of 71%. Their mRNAs are not detected in zygotes. At 14hpf, grass carp igfbp5b mRNA was detected in the somites, while igfbp5a mRNA has some possible signal around the eye and head region. At 24hpf, both igfbp5a and igfbp5b mRNA appear to be limited to the presomitic mesoderm. At 36hpf, igfbp5a mRNA was only detected in the midbrain, while igfbp5b mRNA was detected in both the midbrain and notochord. Overall, both mRNAs were expressed in most adult tissues. igfbp5a and igfbp5b were significantly upregulated in the muscle and liver after injection of 10μg per kilogram body weight of zebrafish growth hormone (zGH), while their hepatic expression was downregulated by 50μg zGH. During fasting, both igfbp5a and igfbp5b mRNAs were significantly downregulated in the muscle but upregulated in the liver. Collectively, the results suggest that the two igfbp5 genes play important but different roles in the regulation of growth and development in grass carp.

  3. CERN permanent exhibitions

    CERN Multimedia

    2016-01-01

    Explore by yourself the issues CERN's physicists are trying to solve: given that the entire universe is made of particles, where do they come from? Why do they behave in the way they do? Discover the massive apparatus used by physicists at CERN, like the LHC, and see how each part works. And if you have more time on site, follow the LHC circuit at ground level to understand in situ this giant machine. Enter our exhibitions. Welcome!

  4. Droplet Lamp Design exhibition

    OpenAIRE

    Unver, Ertu; Dean, Lionel Theodore

    2011-01-01

    This paper describes experiments in the use of digital fluid simulation techniques within a\\ud product design context. It discusses the adoption and adaptation of virtual modelling tools in\\ud 3D creative practice. This work is exhibited at EuroMold, the world-wide fair in Germany for\\ud mold making, tooling, design and application development with around 60.000 visitors and lasts\\ud 4 days. The fair brings together professionals from design, prototyping and manufacturing.

  5. Upcycling CERN Exhibitions

    CERN Multimedia

    Katarina Anthony

    2015-01-01

    Summer is coming - and with it, a new Microcosm exhibition showcasing CERN (see here). But while the new exhibit is preparing to enchant visitors, many have been asking about the site's former content. Will it simply be out with the old and in with the new? Not as such!   The plasma ball from Microcosm is now on display at the LHCb site. As Microcosm's new content is moving in, its old content is moving up. From LHCb to IdeaSquare, former Microcosm displays and objects are being installed across the CERN site. "Microcosm featured many elements that were well suited to life outside of the exhibition," says Emma Sanders, Microcosm project leader in the EDU group. "We didn't want this popular content to go to waste, and so set out to find them new homes across CERN." The LHCb experiment has received a number of Microcosm favourites, including the Rutherford experiment, the cosmic ray display and the Thomson experiment. "We&...

  6. Cancer screening in a middle-aged general population: factors associated with practices and attitudes

    Directory of Open Access Journals (Sweden)

    Perneger Thomas V

    2009-04-01

    Full Text Available Abstract Background The aim of this study was to identify factors associated with cancer screening practices and with general attitudes toward cancer screening in a general population. Methods Mailed survey of 30–60 year old residents of Geneva, Switzerland, that included questions about screening for five cancers (breast, cervix uteri, prostate, colon, skin in the past 3 years, attitudes toward screening, health care use, preventive behaviours and socio-demographic characteristics. Cancer screening practice was dichotomised as having done at least one screening test in the past 3 years versus none. Results The survey response rate was 49.3% (2301/4670. More women than men had had at least one cancer screening test in the past 3 years (83.2% vs 34.5%, p Conclusion Attitudes play an important role in cancer screening practices among middle-aged adults in the general population, independent of demographic variables (age and sex that determine in part screening recommendations. Negative attitudes were the most frequent among men and the most socio-economically disadvantaged. The moderate participation rate raises the possibility of selection bias.

  7. Cancer screening in a middle-aged general population: factors associated with practices and attitudes

    Science.gov (United States)

    Cullati, Stéphane; Charvet-Bérard, Agathe I; Perneger, Thomas V

    2009-01-01

    Background The aim of this study was to identify factors associated with cancer screening practices and with general attitudes toward cancer screening in a general population. Methods Mailed survey of 30–60 year old residents of Geneva, Switzerland, that included questions about screening for five cancers (breast, cervix uteri, prostate, colon, skin) in the past 3 years, attitudes toward screening, health care use, preventive behaviours and socio-demographic characteristics. Cancer screening practice was dichotomised as having done at least one screening test in the past 3 years versus none. Results The survey response rate was 49.3% (2301/4670). More women than men had had at least one cancer screening test in the past 3 years (83.2% vs 34.5%, p cancer screening practices among middle-aged adults in the general population, independent of demographic variables (age and sex) that determine in part screening recommendations. Negative attitudes were the most frequent among men and the most socio-economically disadvantaged. The moderate participation rate raises the possibility of selection bias. PMID:19402895

  8. Factors associated with the choice of general medicine as a career among Japanese medical students

    Directory of Open Access Journals (Sweden)

    Ryuichi Kawamoto

    2016-05-01

    Full Text Available Background: In Japan, there is a shortage of young physicians in various specialties; the present situation of general medicine or family medicine (GM/FM in particular is risky. The factors influencing the career choice of Japanese medical students are poorly understood. This study aims to identify factors related to choosing GM/FM as a career. Methods: The study was designed as a cross-sectional survey. Students at one medical school in Japan filled out a questionnaire. Students were asked to state their intended medical specialty, and they rated the importance of specific individual and occupational aspects using a 4-point likert scale. Factor analysis was performed on the variables. Reliability of the factor scores was estimated using Cronbach‘s alpha coefficients; biserial correlations between the factors and career choices were calculated. Furthermore, multiple linear regression analysis was performed using career choice (GM/FM vs. others as the criterion variable and the factors plus demographic characteristics as confounding variables. Results: Factor analysis produced six factors that explained future career plans. Medical students in this study had a positive and realistic idea about GM/FM, but only 18.8% of them chose GM/FM first as a career. The significant variables associated with choosing GM/FM first as a career were: ‘Admission from hometown’ (β=0.189, P=0.001, ‘Student preparing for the entrance exam’ (β=0.172; P=0.001, ‘Intent for rural practice’ (β=0.123, P=0.016, and ‘Work–life balance’ (β=0.126, P=0.013. While significant variables that were negatively associated with choosing GM/FM were ‘Presence of medical relatives’ (β=−0.107, P=0.037 and ‘Scientific orientation’ (β=−0.125, P=0.013. Conclusions: Strategies have been suggested, such as recruiting medical students with significant variables that were associated with choosing GM/FM first as a career. By engaging students early in their

  9. Contribuciones del factor general y de los factores específicos en la relación entre inteligencia y rendimiento escolar Contributions of the general and the specific factors for the intelligence and school achievement relationship

    Directory of Open Access Journals (Sweden)

    Leandro S. Almeida

    2009-11-01

    Full Text Available

    En este artículo se pretende analizar en qué medida, factores más específicos de la cognición, asociados a contenido verbal, numérico o figurativo, complementan un factor más general de raciocinio en la predicción del rendimiento escolar de los alumnos, al inicio y final de la adolescencia. A una muestra de estudiantes portugueses (n=4.899 entre el 5º y el 12º año de escolaridad, se le aplicó una Batería de Pruebas de Raciocinio en sus tres versiones. El rendimiento escolar de los alumnos se estimó en base a sus clasificaciones en Lengua Portuguesa y Matemáticas. El modelo de ecuaciones estructurales mostró un mayor impacto del factor general (inteligencia fluida-inductiva asociado a todas las pruebas de la BPR en la predicción del rendimiento escolar, observándose que esa significación disminuía progresivamente a lo largo de la escolaridad. Por otro lado, elementos específicos de cada prueba entraron en un segundo modelo, especialmente, en el grupo de los alumnos más jóvenes (5º y 6º año. Entre el 7º y el 9º año las contribuciones específicas de las pruebas se refieren, sobre todo, a la prueba de raciocinio verbal (la prueba de raciocinio numérico aparece también en el 9º año. Así, aún reconociendo la relevancia del factor g en la explicación del rendimiento académico, componentes cognitivos específicos pueden también contribuir para asociar inteligencia y realización académica.

    Palabras clave: Inteligencia, factor g, factores específicos, Gf-Gc, rendimiento académico.

    This paper aims to analyse the extent to which factors more specific cognition, content associated with verbal, numerical or figurative, complement a reasoning general factor in predicting students´ academic achievement at the beginning and the end of adolescence. Taking a Portuguese students sample (n=4,899 from 5th to 12th grades, the reasoning tests battery (BPR – Bateria de Provas de Raciocínio was administrated

  10. Online Exhibits & Concept Maps

    Science.gov (United States)

    Douma, M.

    2009-12-01

    Presenting the complexity of geosciences to the public via the Internet poses a number of challenges. For example, utilizing various - and sometimes redundant - Web 2.0 tools can quickly devour limited time. Do you tweet? Do you write press releases? Do you create an exhibit or concept map? The presentation will provide participants with a context for utilizing Web 2.0 tools by briefly highlighting methods of online scientific communication across several dimensions. It will address issues of: * breadth and depth (e.g. from narrow topics to well-rounded views), * presentation methods (e.g. from text to multimedia, from momentary to enduring), * sources and audiences (e.g. for experts or for the public, content developed by producers to that developed by users), * content display (e.g. from linear to non-linear, from instructive to entertaining), * barriers to entry (e.g. from an incumbent advantage to neophyte accessible, from amateur to professional), * cost and reach (e.g. from cheap to expensive), and * impact (e.g. the amount learned, from anonymity to brand awareness). Against this backdrop, the presentation will provide an overview of two methods of online information dissemination, exhibits and concept maps, using the WebExhibits online museum (www.webexhibits.org) and SpicyNodes information visualization tool (www.spicynodes.org) as examples, with tips on how geoscientists can use either to communicate their science. Richly interactive online exhibits can serve to engage a large audience, appeal to visitors with multiple learning styles, prompt exploration and discovery, and present a topic’s breadth and depth. WebExhibits, which was among the first online museums, delivers interactive information, virtual experiments, and hands-on activities to the public. While large, multidisciplinary exhibits on topics like “Color Vision and Art” or “Calendars Through the Ages” require teams of scholars, user interface experts, professional writers and editors

  11. [Schizotypal Personality Questionnaire-Brief - Likert format: Factor structure analysis in general population in France].

    Science.gov (United States)

    Ferchiou, A; Todorov, L; Lajnef, M; Baudin, G; Pignon, B; Richard, J-R; Leboyer, M; Szöke, A; Schürhoff, F

    2016-09-16

    The main objective of the study was to explore the factorial structure of the French version of the Schizotypal Personality Questionnaire-Brief (SPQ-B) in a Likert format, in a representative sample of the general population. In addition, differences in the dimensional scores of schizotypy according to gender and age were analyzed. As the study in the general population of schizotypal traits and its determinants has been recently proposed as a way toward the understanding of aetiology and pathophysiology of schizophrenia, consistent self-report tools are crucial to measure psychometric schizotypy. A shorter version of the widely used Schizotypal Personality Questionnaire (SPQ-Brief) has been extensively investigated in different countries, particularly in samples of students or clinical adolescents, and more recently, a few studies used a Likert-type scale format which allows partial endorsement of items and reduces the risk of defensive answers. A sample of 233 subjects representative of the adult population from an urban area near Paris (Créteil) was recruited using the "itinerary method". They completed the French version of the SPQ-B with a 5-point Likert-type response format (1=completely disagree; 5=completely agree). We examined the dimensional structure of the French version of the SPQ-B with a Principal Components Analysis (PCA) followed by a promax rotation. Factor selection was based on Eigenvalues over 1.0 (Kaiser's criterion), Cattell's Scree-plot test, and interpretability of the factors. Items with loadings greater than 0.4 were retained for each dimension. The internal consistency estimate of the dimensions was calculated with Cronbach's α. In order to study the influence of age and gender, we carried out a simple linear regression with the subscales as dependent variables. Our sample was composed of 131 women (mean age=52.5±18.2 years) and 102 men (mean age=53±18.1 years). SPQ-B Likert total scores ranged from 22 to 84 points (mean=43.6

  12. From the big five to the general factor of personality: a dynamic approach.

    Science.gov (United States)

    Micó, Joan C; Amigó, Salvador; Caselles, Antonio

    2014-10-28

    An integrating and dynamic model of personality that allows predicting the response of the basic factors of personality, such as the Big Five Factors (B5F) or the general factor of personality (GFP) to acute doses of drug is presented in this paper. Personality has a dynamic nature, i.e., as a consequence of a stimulus, the GFP dynamics as well as each one of the B5F of personality dynamics can be explained by the same model (a system of three coupled differential equations). From this invariance hypothesis, a partial differential equation, whose solution relates the GFP with each one of the B5F, is deduced. From this dynamic approach, a co-evolution of the GFP and each one of the B5F occurs, rather than an unconnected evolution, as a consequence of the same stimulus. The hypotheses and deductions are validated through an experimental design centered on the individual, where caffeine is the considered stimulus. Thus, as much from a theoretical point of view as from an applied one, the models here proposed open a new perspective in the understanding and study of personality like a global system that interacts intimately with the environment, being a clear bet for the high level inter-disciplinary research.

  13. Factores asociados a insulinemia en población general adolescente

    Directory of Open Access Journals (Sweden)

    Rafael Galera Martínez

    2013-10-01

    Full Text Available Objetivo: Analizar los factores asociados con insulinemia en ayunas en población general adolescente. Métodos: Estudio epidemiológico observacional sobre una muestra poblacional de adolescentes (12-16,9 años seleccionados mediante muestreo probabilístico polietápico. Se realizaron examen físico, antropometría, encuesta nutricional y se determinó insulinemia en ayunas. Estadística: regresión lineal múltiple. Resultados: Se incluyeron 379 adolescentes con edad media 14,08 ± 1,30 años. Se relacionaron con mayores cifras de insulinemia el desarrollo puberal [β 4,55 (95% IC 0,42-8,69], obesidad abdominal [β 6,11(95% IC 3,938,29] y el antecedente de bajo peso para la edad gestacional (BPEG [β 7,45 (95% IC 2,47-12,44]. El consumo habitual de aceite de oliva en domicilio mostró una relación inversa con las cifras de insulinemia [β -4,14 (95% IC -7,31- -0,98]. Conclusión: Los factores de riesgo asociados a mayores cifras de insulinemia en ayunas fueron la obesidad abdominal y el antecedente de BPEG. El consumo habitual de aceite de oliva en domicilio fue un factor protector.

  14. 广州会展企业空间集聚特征与影响因素%The agglomeration characteristics and influencing factors of exhibition enterprises in Guangzhou

    Institute of Scientific and Technical Information of China (English)

    方忠权

    2013-01-01

    Exhibition industry is one of the important parts of modern service industry. In recent years, it is developing rapidly and the agglomeration trend in some particular areas of the main center cities is very obvious in China. Based on the data of Guangzhou exhibition enterprises and GIS technology, and using spatial point pattern analysis and questionnaires, this paper discusses the agglomeration characteristics and influencing factors of Guangzhou exhibition enterprises during 1991-2001. Research shows that: (1) Guangzhou exhibition enterprises are significantly agglomerated, and the spatial pattern has been changed from single-center to multi-center agglomeration; (2) Concentration and diffusion coexist. Agglomeration degree of Guangzhou exhibition enterprises does not decrease due to expansion of spatial scale. On the contrary, it diffuses to a new area while constantly strengthening the agglomeration in old areas; (3) Agglomeration areas of exhibition enterprises are divided into two agglomerate types, namely venues-relying type and CBD-relying type, both of which vary in scale and strength of agglomeration; (4) The influencing factors of exhibition enterprises agglomeration include five aspects: exhibition service facilities, overall business environment, external economies, government action and human resources. On the aspect of concrete factors, large exhibition hall and traffic conditions significantly influence the location of exhibition enterprises. But qualified labor force, policy and financial support of the local government, land price and rent have relatively less influence.%会展业是现代服务业重要内容之一,近年来在中国得到快速发展,主要中心城市特定区域的集聚态势十分明显.以广州市会展企业名录为数据基础,借助GIS技术,运用空间点格局分析及问卷调查等方法,探讨了1991-2001年间广州市会展企业的空间集聚特征及影响因素.研究发现,①广州会展企业具有明

  15. Space Shuttle Cockpit exhibit

    Science.gov (United States)

    2000-01-01

    Want to sit in the cockpit of the Space Shuttle and watch astronauts work in outer space? At StenniSphere, you can do that and much more. StenniSphere, the visitor center at John C. Stennis Space Center in Hancock County, Miss., presents 14,000-square-feet of interactive exhibits that depict America's race for space as well as a glimpse of the future. StenniSphere is open free of charge from 9 a.m. to 5 p.m. daily.

  16. General evaluation of hard dental tissue and risk factors of dental caries in young people

    Directory of Open Access Journals (Sweden)

    Антоніна Михайлівна Політун

    2016-04-01

    Full Text Available The prognostication of caries in youth is important for determination and prescription of individual prophylactic arrangements and its further influence on mineralization of the hard dental tissues.Aim of the work: the study of the prevalence and intensity of caries among the young people and determination of possible connection with the risk factor of caries development for further choice of the reasonable prophylactic arrangement.Materials and methods of research: epidemiological, clinical, statistic ones.Results of research: The article describes results of the comprehensive dental examination of 135 persons18-25 years old. There was determined the high prevalence of caries (96,3±0,74 % with considerable intensity (8,87±0,39. The main etiological factors among youth are: poor nutrition with prevalence of carbohydrate (74,81±0,56 %, lack of oral hygiene (59,27±0,73 %, quantitative and qualitative composition of oral fluid, presence of somatic diseases (40±0,30 %, bad habits (31,85±0,24 %, neglect of the sport (48,88±0,36 %, chronic emotional stress (38,51±0,29 %, due to the increased workload and related stress factors.Conclusions: the high prevalence (96,3±0,74 % and intensity of carious process (8,87±0,39 is caused by the unsatisfactory state of oral cavity, (1,91±0,06, under the influence of general factors (somatic diseases, stress, poor nutrition the reactivity of protective mechanisms is lowered and the risk of dental morbidity of youth increases. So, it proves the necessity of elaboration and introduction of the active arrangements of primary prophylaxis directed on the raise of caries resistance of the hard dental tissues in young people

  17. A Rasch and confirmatory factor analysis of the General Health Questionnaire (GHQ - 12

    Directory of Open Access Journals (Sweden)

    Velikova Galina

    2010-04-01

    Full Text Available Abstract Background The General Health Questionnaire (GHQ - 12 was designed as a short questionnaire to assess psychiatric morbidity. Despite the fact that studies have suggested a number of competing multidimensional factor structures, it continues to be largely used as a unidimensional instrument. This may have an impact on the identification of psychiatric morbidity in target populations. The aim of this study was to explore the dimensionality of the GHQ-12 and to evaluate a number of alternative models for the instrument. Methods The data were drawn from a large heterogeneous sample of cancer patients. The Partial Credit Model (Rasch was applied to the 12-item GHQ. Item misfit (infit mean square ≥ 1.3 was identified, misfitting items removed and unidimensionality and differential item functioning (age, gender, and treatment aims were assessed. The factor structures of the various alternative models proposed in the literature were explored and optimum model fit evaluated using Confirmatory Factor Analysis. Results The Rasch analysis of the 12-item GHQ identified six misfitting items. Removal of these items produced a six-item instrument which was not unidimensional. The Rasch analysis of an 8-item GHQ demonstrated two unidimensional structures corresponding to Anxiety/Depression and Social Dysfunction. No significant differential item functioning was observed by age, gender and treatment aims for the six- and eight-item GHQ. Two models competed for best fit from the confirmatory factor analysis, namely the GHQ-8 and Hankin's (2008 unidimensional model, however, the GHQ-8 produced the best overall fit statistics. Conclusions The results are consistent with the evidence that the GHQ-12 is a multi-dimensional instrument. Use of the summated scores for the GHQ-12 could potentially lead to an incorrect assessment of patients' psychiatric morbidity. Further evaluation of the GHQ-12 with different target populations is warranted.

  18. Designing an exhibition

    DEFF Research Database (Denmark)

    Ingemann, Bruno

    2010-01-01

    by following the design-thinking processes in detail. The fundamental concept is an introverted analysis completed by giving one person two roles, that of designer and researcher. The result is a dialogue concerning the processual experience as a reflection-in-action. The contribution to a general core...

  19. Improved theory of generalized meteo-ballistic weighting factor functions and their use

    Directory of Open Access Journals (Sweden)

    Vladimir Cech

    2016-06-01

    Full Text Available It follows from the analysis of artillery fire errors that approximately two-thirds of the inaccuracy of indirect artillery fire is caused by inaccuracies in the determination of the meteo parameters included in fire error budget model. Trajectories calculated under non-standard conditions are considered to be perturbed. The tools utilized for the analysis of perturbed trajectories are weighting factor functions (WFFs which are a special kind of sensitivity functions. WFFs are used for calculation of meteo ballistic elements µB (ballistic wind wB, density ρB, virtual temperature τB, pressure pB as well. We have found that the existing theory of WFF calculation has several significant shortcomings. The aim of the article is to present a new, improved theory of generalized WFFs that eliminates the deficiencies found. Using this theory will improve methods for designing firing tables, fire control systems algorithms, and meteo message generation algorithms.

  20. Mammographic texture resemblance generalizes as an independent risk factor for breast cancer

    DEFF Research Database (Denmark)

    Nielsen, Mads; Vachon, Celine M.; Scott, Christopher G.

    2014-01-01

    density. We examine if these findings generalize to another population.METHODS:Texture patterns were recorded in digitalized pre-diagnosis (3.7years) film mammograms of a nested case-control study within the Dutch screening program (S1) comprising of 245 breast cancers and 250 matched controls....... The patterns were recognized in the same study using cross-validation to form resemblance scores associated with breast cancer. Texture patterns from S1 were examined in an independent nested case-control study within the Mayo Mammography Health Study cohort (S2) of 226 cases and 442 matched controls......: mammograms on average 8.5years prior to diagnosis, risk factor information and percent mammographic density (PD) estimated using Cumulus were available. MTR scores estimated from S1, S2 and S1+S2 (the latter two as cross-validations) were evaluated in S2. MTR scores were analyzed as both quartiles...

  1. [The general intelligence factor: psychometric study. Approach to the problem of mental deterioration].

    Science.gov (United States)

    Roccatagliata, G; Albano, C; Torres, S; Cocito, L; Ivaldi, M

    1979-01-01

    The authors have measured the correlation coefficient between W.B. and P.M. scores in 80 normal subjects, comparable for age and school. A mutual relationship between the two tests, connected by the hypothetical general intelligence factor "g", was really demonstrated. Correlation coefficient was positive and significative between W.B. total scores, excepted verbal scores, and P.M., the highest one between subtests 8, 9 and P.M. The intra-tests correlation between W.B. total scores and each subtest score was also evaluated: between sub-tests 8, 9 and W.B. total scores the highest one again. A new qualitative interpretation of mental deterioration in clinical neurology and psychiatry is suggested on the base of these results.

  2. Transcriptional control of yeast ribosome biogenesis: A multifaceted role for general regulatory factors.

    Science.gov (United States)

    Bosio, Maria Cristina; Fermi, Beatrice; Dieci, Giorgio

    2017-08-08

    In Saccharomyces cerevisiae, a group of more than 200 co-regulated genes (Ribi genes) is involved in ribosome biogenesis. This regulon has recently been shown to rely on a small set of transcriptional regulators (mainly Abf1, but also Reb1, Tbf1 and Rap1) previously referred to as general regulatory factors (GRFs) because of their widespread binding and action at many promoters and other specialized genomic regions. Intriguingly, Abf1 binding to Ribi genes is differentially modulated in response to distinct nutrition signaling pathways. Such a dynamic promoter association has the potential to orchestrate both activation and repression of Ribi genes in synergy with neighboring regulatory sites and through the functional interplay of histone acetyltransferases and deacetylases.

  3. Probabilistic Inference from Arbitrary Uncertainty using Mixtures of Factorized Generalized Gaussians

    CERN Document Server

    Garrido, M C; Ruiz, A; 10.1613/jair.533

    2011-01-01

    This paper presents a general and efficient framework for probabilistic inference and learning from arbitrary uncertain information. It exploits the calculation properties of finite mixture models, conjugate families and factorization. Both the joint probability density of the variables and the likelihood function of the (objective or subjective) observation are approximated by a special mixture model, in such a way that any desired conditional distribution can be directly obtained without numerical integration. We have developed an extended version of the expectation maximization (EM) algorithm to estimate the parameters of mixture models from uncertain training examples (indirect observations). As a consequence, any piece of exact or uncertain information about both input and output values is consistently handled in the inference and learning stages. This ability, extremely useful in certain situations, is not found in most alternative methods. The proposed framework is formally justified from standard prob...

  4. Prevalence and Factors Affecting Dysmenorrhea in Female University Students: Effect on General Comfort Level.

    Science.gov (United States)

    Aktaş, Demet

    2015-08-01

    The purpose of this study was to investigate the prevalence and the affecting factors of dysmenorrhea and its effects on overall comfort among female university students. This was a cross-sectional study. The research was carried out between October and November 2013 at a university in Ankara. This study was conducted with 200 female students. The data were analyzed using frequencies, means, SD, χ(2) tests, independent t tests and analysis of variance. Data were collected using an interview questionnaire, the visual analog scale (VAS) and the General Comfort Questionnaire. The mean age of students in this study group was 20.85 ± 2.15 years. The prevalence of dysmenorrhea in the students was 84%. The mean severity of pain was 5.78 ± 2.45 on the VAS. The present study found that 45.8% of female students experienced moderate menstrual pain and the most common co-occurring symptoms were irritability (34.6%) and fatigue (21.5%). One-fourth of the students with dysmenorrhea consulted the advice of a physician and the most commonly used methods for pain were analgesics (69%), heat application (56.5%), and rest (71.4%). Family history of dysmenorrhea, education about menstruation, and frequency of menstrual cycle were identified as important factors in the development of dysmenorrhea (p students with dysmenorrhea (2.57 ± 0.25) was lower than that of students without the condition (2.65 ± 0.23). Also, use of the methods for management of dysmenorrhea was found to increase students' general comfort levels. Therefore, it is important for nurses to educate and advise adolescents and young women about dysmenorrhea.

  5. General Practitioners' perceptions of their role in cancer care and factors which influence this role.

    Science.gov (United States)

    Mitchell, Geoffrey K; Burridge, Letitia H; Colquist, Shoni P; Love, Alison

    2012-11-01

    Effective cancer care depends on inter-sectoral and inter-professional communication. General Practitioners (GPs) play a pivotal role in managing the health of most Australians, but their role in cancer care is unclear. This qualitative study explored GPs' views of this role and factors influencing their engagement with cancer care. Twelve metropolitan and non-metropolitan GPs in Queensland, Australia, were recruited between April and May 2008, and three focus groups and one interview were conducted using open-ended questions. The transcripts were analysed thematically. The first theme, GPs' perceptions of their role, comprised subthemes corresponding to four phases of the trajectory. The second theme, Enhancing GPs' involvement in ongoing cancer care, comprised subthemes regarding enhanced communication and clarification of roles and expectations. GPs' role in cancer care fluctuates between active advocacy during diagnosis and palliation, and ambivalent redundancy in between. The role is influenced by socioeconomic, clinical and geographical factors, patients' expectations and GPs' motivation. Not all participants wanted an enhanced role in cancer care, but all valued better specialist-GP communication. Role clarification is needed, together with greater mutual trust between GPs and specialists. Key needs included accessible competency training and mentoring for doctors unfamiliar with the system. Existing system barriers and workforce pressures in general practice must be addressed to improve the sharing of cancer care. Only one metropolitan focus group was conducted, so saturation of themes may not have been reached. The challenges of providing cancer care in busy metropolitan practices are multiplied in non-metropolitan settings with less accessible resources and where distance affects specialist communication. Non-metropolitan GPs learn from experience how to overcome referral and communication challenges. While the GPs identified solutions to their concerns

  6. Anniversary Exhibition. Nechvolodov.

    Directory of Open Access Journals (Sweden)

    - -

    2006-03-01

    Full Text Available On the 10th of August, 2005 in Tartu (the second biggest educational and cultural city in Estonia Stanislav Nechvolodov's exhibition was opened to show the 5-year cycle of his work, traditional for the author and his admirers. At the opening ceremony Nechvolodov said that the exhibition was the last one and appointed on his 70th anniversary.The architectural and building society in Irkutsk remembers Stanislav Nechvolodov as an architect working on dwelling and civil buildings in 1960-70s. Below are some extracts from the Estonian press.«Postimees» newspaper, December 1993. The interview «Expressionistic naturalist, conservative Nechvolodov» by journalist Eric Linnumyagi. He asks about all the details and describes the troubles experienced by Nechvolodov during the perestroika period in Estonia, for example: the Tartu University refused to install the sculpture of Socrat, the art school refused to engage him as an instructor, the sculpture of Socrat moved to Vrotzlav, Poland, and Nechvolodov moved to Poland to read lectures there.«Tartu» newspaper, November 2000. Mats Oun, artist, says in the article «Nechvolodov: a man of Renaissance»: «Nechvolodov works in Estonia, his works are placed in many local and foreign museums. Regardless some insignificant faults, he deserves a high estimation, and his manysided open exhibition can be an example for other artists. He is a man of Renaissance».

  7. The Factor Decomposition Theorem of Bounded Generalized Inverse Modules and Their Topological Continuity

    Institute of Scientific and Technical Information of China (English)

    Lun Chuan ZHANG

    2007-01-01

    In this paper we obtain a Douglas type factor decomposition theorem about certain important bounded module maps. Thus, we come to the discussion of the topological continuity of bounded generalized inverse module maps .Let be a topological space, x →T x : X→L (E)be a continuous map, and each R (x) be a closed submodule in E , for every fixed x ∈X . Then the map x →T+x : X→L (E) is continuous if and only if ||T+x||is locally bounded, where T+x is the bounded generalized inverse module map of T x. Furthermore, this is equivalent to the following statement:For each x 0 in X , there exists a neighborhood U 0 at x 0 and a positive number λ such that (0λ2)(C)∩x ∈U 0 C \\σ (T*x T x), where σ (T) denotes the spectrum of operator T .

  8. Factors affecting the technical efficiency of general hospitals in Iran: data envelopment analysis.

    Science.gov (United States)

    Kalhor, Rohollah; Amini, Saeed; Sokhanvar, Mobin; Lotfi, Farhad; Sharifi, Marziye; Kakemam, Edris

    2016-03-01

    Restrictions on resource accessibility and its optimal application is the main challenge in organizations nowadays. The aim of this research was to study the technical efficiency and its related factors in Tehran general hospitals. This descriptive analytical study was conducted retrospectively in 2014. Fifty-four hospitals with private, university, and social security ownerships from the total 110 general hospitals were randomly selected for inclusion into this study on the basis of the share of ownership. Data were collected using a checklist with three sections, including background variables, inputs, and outputs. Seventeen (31.48%) hospitals had an efficiency score of 1 (highest efficiency score). The highest average efficiency score was in social security hospitals (84.32). Private and university hospitals ranked next with an average of 84.29 and 79.64, respectively. Analytical results showed that there was a significant relationship between hospital ownership, hospital type in terms of duty and specialization, educational field of the chief executive officer, and technical efficiency. There was no significant relationship between education level of hospital manager and technical efficiency. Most of the studied hospitals were operating at low efficiency. Therefore, policymakers should plan to improve the hospital operations and promote hospitals to an optimal level of efficiency.

  9. Genetic characterization of general transcription factors TFIIF and TFIIB of Homo sapiens sapiens.

    Science.gov (United States)

    Purrello, M; Di Pietro, C; Rapisarda, A; Mirabile, E; Motta, S; Sichel, G; Grzeschik, K H

    1995-01-01

    Analysis of loci GTF2F1 and GTF2B, encoding Rap 74 (a subunit of TFIIF) and TFIIB, respectively, showed that they are present in a single copy in the human genome and are localized at 19p13.3 and 1p22, respectively. By using as probe a cDNA for Rap 30 (the other subunit of TFIIF), we localized the GTF2F2 locus to 13q14; the same probe also detected a cross-hybridizing sequence at 4q31 whose functional importance remains to be elucidated. These data and those previously published by our group demonstrate that genes coding for class II general transcription factors with reported sequence similarity to bacterial sigma proteins are scattered in different regions of the human genome, with no evidence of clustering. This dispersion and the identification of homologs of both TBP and TFIIB in Archaea suggest an early evolutionary origin of the general transcription apparatus of contemporary eukaryotes.

  10. "Big Science" exhibition at Balexert

    CERN Multimedia

    2008-01-01

    CERN is going out to meet those members of the general public who were unable to attend the recent Open Day. The Laboratory will be taking its "Big Science" exhibition from the Globe of Science and Innovation to the Balexert shopping centre from 19 to 31 May 2008. The exhibition, which shows the LHC and its experiments through the eyes of a photographer, features around thirty spectacular photographs measuring 4.5 metres high and 2.5 metres wide. Welcomed and guided around the exhibition by CERN volunteers, shoppers at Balexert will also have the opportunity to discover LHC components on display and watch films. "Fun with Physics" workshops will be held at certain times of the day. Main hall of the Balexert shopping centre, ground floor, from 9.00 a.m. to 7.00 p.m. Monday to Friday and from 10 a.m. to 6 p.m. on the two Saturdays. Call for volunteers All members of the CERN personnel are invited to enrol as volunteers to help welcom...

  11. Delays and Factors Related to Cessation of Generalized Convulsive Status Epilepticus

    Directory of Open Access Journals (Sweden)

    Leena Kämppi

    2015-01-01

    Full Text Available Introduction. This study was designed to identify the delays and factors related to and predicting the cessation of generalized convulsive SE (GCSE. Methods. This retrospective study includes 70 consecutive patients (>16 years diagnosed with GCSE and treated in the emergency department of a tertiary hospital over 2 years. We defined cessation of SE stepwise using clinical seizure freedom, achievement of burst-suppression, and return of consciousness as endpoints and calculated delays for these cessation markers. In addition 10 treatment delay parameters and 7 prognostic and GCSE episode related factors were defined. Multiple statistical analyses were performed on their relation to cessation markers. Results. Onset-to-second-stage-medication (p=0.027, onset-to-burst-suppression (p=0.005, and onset-to-clinical-seizure-freedom (p=0.035 delays correlated with the onset-to-consciousness delay. We detected no correlation between age, epilepsy, STESS, prestatus period, type of SE onset, effect of the first medication, and cessation of SE. Conclusion. Our study demonstrates that rapid administration of second-stage medication and early obtainment of clinical seizure freedom and burst-suppression predict early return of consciousness, an unambiguous marker for the end of SE. We propose that delays in treatment chain may be more significant determinants of SE cessation than the previously established outcome predictors. Thus, streamlining the treatment chain is advocated.

  12. A general strategy for cellular reprogramming: the importance of transcription factor cross-repression.

    Science.gov (United States)

    Crespo, Isaac; Del Sol, Antonio

    2013-10-01

    Transcription factor cross-repression is an important concept in cellular differentiation. A bistable toggle switch constitutes a molecular mechanism that determines cellular commitment and provides stability to transcriptional programs of binary cell fate choices. Experiments support that perturbations of these toggle switches can interconvert these binary cell fate choices, suggesting potential reprogramming strategies. However, more complex types of cellular transitions could involve perturbations of combinations of different types of multistable motifs. Here, we introduce a method that generalizes the concept of transcription factor cross-repression to systematically predict sets of genes, whose perturbations induce cellular transitions between any given pair of cell types. Furthermore, to our knowledge, this is the first method that systematically makes these predictions without prior knowledge of potential candidate genes and pathways involved, providing guidance on systems where little is known. Given the increasing interest of cellular reprogramming in medicine and basic research, our method represents a useful computational methodology to assist researchers in the field in designing experimental strategies.

  13. Structural basis for converting a general transcription factor into an operon-specific virulence regulator.

    Science.gov (United States)

    Belogurov, Georgiy A; Vassylyeva, Marina N; Svetlov, Vladimir; Klyuyev, Sergiy; Grishin, Nick V; Vassylyev, Dmitry G; Artsimovitch, Irina

    2007-04-13

    RfaH, a paralog of the general transcription factor NusG, is recruited to elongating RNA polymerase at specific regulatory sites. The X-ray structure of Escherichia coli RfaH reported here reveals two domains. The N-terminal domain displays high similarity to that of NusG. In contrast, the alpha-helical coiled-coil C domain, while retaining sequence similarity, is strikingly different from the beta barrel of NusG. To our knowledge, such an all-beta to all-alpha transition of the entire domain is the most extreme example of protein fold evolution known to date. Both N domains possess a vast hydrophobic cavity that is buried by the C domain in RfaH but is exposed in NusG. We propose that this cavity constitutes the RNA polymerase-binding site, which becomes unmasked in RfaH only upon sequence-specific binding to the nontemplate DNA strand that triggers domain dissociation. Finally, we argue that RfaH binds to the beta' subunit coiled coil, the major target site for the initiation sigma factors.

  14. Human factors in general practice - early thoughts on the educational focus for specialty training and beyond.

    Science.gov (United States)

    McKay, John; Pickup, Laura; Atkinson, Sarah; McNab, Duncan; Bowie, Paul

    2016-05-01

    In the third article in the series, we describe the outputs from a series of roundtable discussions by Human Factors experts and General Practice (GP) Educational Supervisors tasked with examining the GP (family medicine) training and work environments through the lens of the systems and designed-centred discipline of Human Factors and Ergonomics (HFE). A prominent issue agreed upon proposes that the GP setting should be viewed as a complex sociotechnical system from a care service and specialty training perspective. Additionally, while the existing GP specialty training curriculum in the United Kingdom (UK) touches on some important HFE concepts, we argue that there are also significant educational gaps that could be addressed (e.g. physical workplace design, work organisation, the design of procedures, decision-making and human reliability) to increase knowledge and skills that are key to understanding workplace complexity and interactions, and supporting everyday efforts to improve the performance and wellbeing of people and organisations. Altogether we propose and illustrate how future HFE content could be enhanced, contexualised and integrated within existing training arrangements, which also serves as a tentative guide in this area for continuing professional development for the wider GP and primary care teams.

  15. Activation of hypoxia inducible factor 1 is a general phenomenon in infections with human pathogens.

    Directory of Open Access Journals (Sweden)

    Nadine Werth

    Full Text Available BACKGROUND: Hypoxia inducible factor (HIF-1 is the key transcriptional factor involved in the adaptation process of cells and organisms to hypoxia. Recent findings suggest that HIF-1 plays also a crucial role in inflammatory and infectious diseases. METHODOLOGY/PRINCIPAL FINDINGS: Using patient skin biopsies, cell culture and murine infection models, HIF-1 activation was determined by immunohistochemistry, immunoblotting and reporter gene assays and was linked to cellular oxygen consumption. The course of a S. aureus peritonitis was determined upon pharmacological HIF-1 inhibition. Activation of HIF-1 was detectable (i in all ex vivo in biopsies of patients suffering from skin infections, (ii in vitro using cell culture infection models and (iii in vivo using murine intravenous and peritoneal S. aureus infection models. HIF-1 activation by human pathogens was induced by oxygen-dependent mechanisms. Small colony variants (SCVs of S. aureus known to cause chronic infections did not result in cellular hypoxia nor in HIF-1 activation. Pharmaceutical inhibition of HIF-1 activation resulted in increased survival rates of mice suffering from a S. aureus peritonitis. CONCLUSIONS/SIGNIFICANCE: Activation of HIF-1 is a general phenomenon in infections with human pathogenic bacteria, viruses, fungi and protozoa. HIF-1-regulated pathways might be an attractive target to modulate the course of life-threatening infections.

  16. Factor Affecting Hipertension Incidence to Papuan Ethnic at Yowari General Hospital Sentani Jayapura Regency Papuan Province

    Directory of Open Access Journals (Sweden)

    Elpida Elpida

    2017-01-01

    Full Text Available High blood pressure or hupertension often being called silent killer and mortality that excelsior because kill gently ala. Mark sense urbanization to Province Papuaning to cause changing Regency Papuan society life style Jayapura experiences changing. Of RSUD Yowari's data hypertension instance experiences step-up. There is purpose was to know factor affecting Hiptension Incidence To Papuan Ethnic At Yowari General Hospital Sentani Jayapura Regency Papuan Province. Observasional by designs studi case control. Population all patient comes from Papuan ethnic that visits at Poli Disease In Yowari general hospital Sentani Jayapura Regency on month of May until July 2016 totals 379 person. Outgrow sample as much 41 cases and 41 controls. Data approach used questionaire and analyzed by chi square and odd ratio. The results shows that there is corelatyion afecting hypertension incidence on Papuan ethnic at Yowari general hospital is aged (p value 0,039; OR= 2,952; CI95%= 1,154 – 7,556, genetic (p value 0,001; OR= 5,260; CI95%= 2,043 – 13,539, activity phisic (p value 0,001; OR= 3,733; CI95%= 1,496 – 9,318, obesity (p value 0,008; OR = 3,733; CI95%= 1,496 – 9,318, smoking (p value 0,008; OR= 3,563; CI95%= 1,328 – 9,555, coffe drunk (p value 0,013; OR= 3,589; CI95%= 1,401 – 6,227, diseased history (p value 0,000; OR= 6,445; CI95%= 2,383 – 17,436 and stress (p value 0,000; OR= 6,445; CI95%= 2,383 – 17,436. Meanwhile variable that not corelation affecting is sex (p value 0,376; OR = 1,635; CI95%= 0,683 – 3,915, education (p value 0,825; OR = 0,822; CI95%= 0,345 – 1,960, work (p value 0,180; OR = 0,494; CI95%= 0,203 – 1,202, income (p value 0,252; 0,539; CI95% (0,212 – 1,317, alcohol drunk (p value 0,103; OR = 2,426; CI95%= 0,945 – 6,227. Dominan factor incidence hpertension is aged, genetic, activity, obesity, salt consumption and hystory disease.

  17. Suspectable Risk Factors of Congenital Anomaly in Dr. Hasan Sadikin General Hospital Bandung, Indonesia

    Directory of Open Access Journals (Sweden)

    Pradistya Syifa Yudiasari

    2017-06-01

    Full Text Available Background: Congenital anomaly is a disease of structural or functional alteration since birth. The cause of congenital anomaly is genetic, environtment, and unknown. The cause of congenital anomaly is unknown, made congenital anomaly is difficult to detect. Therefore, the objective of this study was to identify the suspectable risk factors of congenital anomaly. Methods: This was a descriptive study. About 78 samples were taken by purposive sampling from medical records of patients with congenital anomaly in pediatric surgery ambulatory unit at Dr. Hasan Sadikin General Hospital (RSHS, Bandung from September to November 2014. From the selected medical records, an interview was carried out to the parents’ patient to identify some suspectable risk factors. The collected data were analyzed and presented in tables. Results: From 78 medical records,  hirschprung disease was the highest among all type of congenital anomaly (29%. The characteristic of congenital anomaly was mothers in the age of 20–35 years (65%, fathers’ age was  more than 20 years old, family history of congenital anomaly was 1%, there was no history of previous congenital anomaly in previous pregnancy, infection history was 3%, history of medication was 11.5%, mother’s BMI was in normal term (18.5─24.9 as much as 65%, no history of radiation, there was no history of chronic alcohol. History of smoking/passive smoking was high (65%. Conclusions: Hirschprung disease is the highest rate disease in congenital anomaly and smoking is a highest suspectable risk factor contribute to congenital anomaly.   DOI: 10.15850/amj.v4n2.1095

  18. Domain-Specific and Domain-General Learning Factors Are Expressed in Genetically Heterogeneous CD-1 Mice

    Science.gov (United States)

    Kolata, Stefan; Light, Kenneth; Matzel, Louis D.

    2008-01-01

    It has been established that both domain-specific (e.g. spatial) as well as domain-general (general intelligence) factors influence human cognition. However, the separation of these processes has rarely been attempted in studies using laboratory animals. Previously, we have found that the performances of outbred mice across a wide range of…

  19. The Peripheral Arterial disease study (PERART/ARTPER: prevalence and risk factors in the general population

    Directory of Open Access Journals (Sweden)

    Vicheto Marisa

    2010-01-01

    Full Text Available Abstract Background The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index is a good marker of vascular events and may be diminished without presenting symptomatology (silent peripheral arterial disease. The aim of the study is to know the prevalence and associated risk factors of peripheral arterial disease in the general population. Methods We performed a cross-sectional, multicentre, population-based study in 3786 individuals >49 years, randomly selected in 28 primary care centres in Barcelona (Spain. Peripheral arterial disease was evaluated using the ankle-arm index. Values Results The prevalence (95% confidence interval of peripheral arterial disease was 7.6% (6.7-8.4, (males 10.2% (9.2-11.2, females 5.3% (4.6-6.0; p Multivariate analysis showed the following risk factors: male sex [odds ratio (OR 1.62; 95% confidence interval 1.01-2.59]; age OR 2.00 per 10 years (1.64-2.44; inability to perform physical activity [OR 1.77 (1.17-2.68 for mild limitation to OR 7.08 (2.61-19.16 for breathless performing any activity]; smoking [OR 2.19 (1.34-3.58 for former smokers and OR 3.83 (2.23-6.58 for current smokers]; hypertension OR 1.85 (1.29-2.65; diabetes OR 2.01 (1.42-2.83; previous cardiovascular disease OR 2.19 (1.52-3.15; hypercholesterolemia OR 1.55 (1.11-2.18; hypertriglyceridemia OR 1.55 (1.10-2.19. Body mass index ≥25 Kg/m2 OR 0.57 (0.38-0.87 and walking >7 hours/week OR 0.67 (0.49-0.94 were found as protector factors. Conclusions The prevalence of peripheral arterial disease is low, higher in males and increases with age in both sexes. In addition to previously described risk factors we found a protector effect in physical exercise and overweight.

  20. Generalized Squashing Factors for Covariant Description of Magnetic Connectivity in the Solar Corona

    Science.gov (United States)

    Titov, V. S.

    2007-01-01

    The study of magnetic connectivity in the solar corona reveals a need to generalize the field line mapping technique to arbitrary geometry of the boundaries and systems of coordinates. Indeed, the global description of the connectivity in the corona requires the use of the photospheric and solar wind boundaries. Both are closed surfaces and therefore do not admit a global regular system of coordinates. At least two overlapping regular systems of coordinates for each of the boundaries are necessary in this case to avoid spherical-pole-like singularities in the coordinates of the footpoints. This implies that the basic characteristic of magnetic connectivity-the squashing degree or factor Q of elemental flux tubes, according to Titov and coworkers-must be rewritten in covariant form. Such a covariant expression of Q is derived in this work. The derived expression is very flexible and highly efficient for describing the global magnetic connectivity in the solar corona. In addition, a general expression for a new characteristic Q1, which defines a squashing of the flux tubes in the directions perpendicular to the field lines, is determined. This new quantity makes it possible to filter out the quasi-separatrix layers whose large values of Q are caused by a projection effect at the field lines nearly touching the photosphere. Thus, the value Q1 provides a much more precise description of the volumetric properties of the magnetic field structure. The difference between Q and Q1 is illustrated by comparing their distributions for two configurations, one of which is the Titov-Demoulin model of a twisted magnetic field.

  1. Measuring factors that influence the utilisation of preventive care services provided by general practitioners in Australia

    Directory of Open Access Journals (Sweden)

    Oldenburg Brian

    2009-12-01

    Full Text Available Abstract Background Relatively little research attention has been given to the development of standardised and psychometrically sound scales for measuring influences relevant to the utilisation of health services. This study aims to describe the development, validation and internal reliability of some existing and new scales to measure factors that are likely to influence utilisation of preventive care services provided by general practitioners in Australia. Methods Relevant domains of influence were first identified from a literature review and formative research. Items were then generated by using and adapting previously developed scales and published findings from these. The new items and scales were pre-tested and qualitative feedback was obtained from a convenience sample of citizens from the community and a panel of experts. Principal Components Analyses (PCA and internal reliability testing (Cronbach's alpha were then conducted for all of the newly adapted or developed scales utilising data collected from a self-administered mailed survey sent to a randomly selected population-based sample of 381 individuals (response rate 65.6 per cent. Results The PCA identified five scales with acceptable levels of internal consistency were: (1 social support (ten items, alpha 0.86; (2 perceived interpersonal care (five items, alpha 0.87, (3 concerns about availability of health care and accessibility to health care (eight items, alpha 0.80, (4 value of good health (five items, alpha 0.79, and (5 attitudes towards health care (three items, alpha 0.75. Conclusion The five scales are suitable for further development and more widespread use in research aimed at understanding the determinants of preventive health services utilisation among adults in the general population.

  2. Objective Sleep Structure and Cardiovascular Risk Factors in the General Population: The HypnoLaus Study

    Science.gov (United States)

    Haba-Rubio, José; Marques-Vidal, Pedro; Andries, Daniela; Tobback, Nadia; Preisig, Martin; Vollenweider, Peter; Waeber, Gérard; Luca, Gianina; Tafti, Mehdi; Heinzer, Raphaël

    2015-01-01

    Study Objectives: To evaluate the association between objective sleep measures and metabolic syndrome (MS), hypertension, diabetes, and obesity. Design: Cross-sectional study. Setting: General population sample. Participants: There were 2,162 patients (51.2% women, mean age 58.4 ± 11.1). Interventions: Patients were evaluated for hypertension, diabetes, overweight/obesity, and MS, and underwent a full polysomnography (PSG). Measurements and Results: PSG measured variables included: total sleep time (TST), percentage and time spent in slow wave sleep (SWS) and in rapid eye movement (REM) sleep, sleep efficiency and arousal index (ArI). In univariate analyses, MS was associated with decreased TST, SWS, REM sleep, and sleep efficiency, and increased ArI. After adjustment for age, sex, smoking, alcohol, physical activity, drugs that affect sleep and depression, the ArI remained significantly higher, but the difference disappeared in patients without significant sleep disordered breathing (SDB). Differences in sleep structure were also found according to the presence or absence of hypertension, diabetes, and overweight/obesity in univariate analysis. However, these differences were attenuated after multivariate adjustment and after excluding subjects with significant SDB. Conclusions: In this population-based sample we found significant associations between sleep structure and metabolic syndrome (MS), hypertension, diabetes, and obesity. However, these associations were cancelled after multivariate adjustment. We conclude that normal variations in sleep contribute little if any to MS and associated disorders. Citation: Haba-Rubio J, Marques-Vidal P, Andries D, Tobback N, Preisig M, Vollenweider P, Waeber G, Luca G, Tafti M, Heinzer R. Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus study. SLEEP 2015;38(3):391–400. PMID:25325467

  3. Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population

    Science.gov (United States)

    Mazza, Alberto; Lenti, Salvatore; Schiavon, Laura; Del Monte, Alvise; Townsend, Danyelle M.; Ramazzina, Emilio; Rubello, Domenico; Casiglia, Edoardo

    2017-01-01

    Objective In clinical practice, patient characteristics predicting resistant hypertension (RH) include higher blood pressure levels, left ventricular hypertrophy, older age, obesity, chronic kidney disease and diabetes. On the contrary little is known about the role of serum uric acid (SUA) as a risk factor for RH in subjects from general population. Material and methods 580 elderly subjects aged ≥65 years were enrolled in the Risk Of Vascular complications Impact of Genetics in Old people (ROVIGO) study. RH was defined as the failure to maintain blood pressure values below 140 mmHg (systolic) and 90 mmHg (diastolic) despite therapeutic interventions that include appropriate lifestyle measures plus adherence to treatment with full doses of at least three antihypertensive drugs, including a diuretic. RH was confirmed using 24-h ambulatory blood pressure measurement. Hyperuricemic was defined as the subjects having SUA ≥6.8 mg/dl or taking uricosuric drugs. Gender-specific odds ratio (OR) for RH was calculated by logistic regression analysis. Results The prevalence of RH was 5.7% in the cohort and was higher in women (8.3%) than in men (3.0%, p hypertension in women (odds ratio 3.11, 95% confidence intervals 1.06–9.1, p = 0.03) but not in men. Conclusions In elderly women from the general population, an SUA value of ≥6.8 mg/dl triples the risk of RH. SUA assessment should be recommended to better define the pattern of risk associated with RH. PMID:28027534

  4. The Contributions of Domain-General and Numerical Factors to Third-Grade Arithmetic Skills and Mathematical Learning Disability

    Science.gov (United States)

    Cowan, Richard; Powell, Daisy

    2014-01-01

    Explanations of the marked individual differences in elementary school mathematical achievement and mathematical learning disability (MLD or dyscalculia) have involved domain-general factors (working memory, reasoning, processing speed, and oral language) and numerical factors that include single-digit processing efficiency and multidigit skills…

  5. Predicting Homophobic Behavior among Heterosexual Youth: Domain General and Sexual Orientation-Specific Factors at the Individual and Contextual Level

    Science.gov (United States)

    Poteat, V. Paul; DiGiovanni, Craig D.; Scheer, Jillian R.

    2013-01-01

    As a form of bias-based harassment, homophobic behavior remains prominent in schools. Yet, little attention has been given to factors that underlie it, aside from bullying and sexual prejudice. Thus, we examined multiple domain general (empathy, perspective-taking, classroom respect norms) and sexual orientation-specific factors (sexual…

  6. Presampling, algorithm factors, and noise: considerations for CT in particular and for medical imaging in general.

    Science.gov (United States)

    Kachelriess, Marc; Kalender, Willi A

    2005-05-01

    CT scanners acquire noisy data at discrete sample positions. Typically, a convention of how to continue these data from discrete integer positions to the continuous domain must be applied during processing. We study the properties of three typical one-dimensional spatial domain interpolation algorithms in terms of a cost or quality factor Q. This figure of merit Q is a function of spatial resolution, data noise, and dose and is used to optimize detector design. Spatial resolution R is defined as either mean square width delta or as the full width at half maximum W of the point spread function (PSF). Our results show that a trapezoidal interpolation algorithm is optimal for the high resolution domain (relative to the detector aperture size g) and should be replaced by a triangular or Gaussian interpolation function for spatial resolutions of about 1.3g or larger; these result in bell-shaped PSFs. Assuming such a hybrid algorithm we find a 1.5-fold increase of Q2-this is equivalent to 50% improved dose usage-when smoothing the data to a spatial resolution of 3g or more compared to a highest resolution reconstruction. Therefore it is advisable to use detectors of one-third of the size of the desired spatial resolution W and to compensate for the 1.5-fold increase in Q2 by reducing dose by 33%. Under the presence of moderately sized septa (e.g., 10% of the spatial resolution element size) the benefit of optimizing still lies in the order of 30% improved dose usage; in that case the detector size g should be on the order of W/2 and a dose reduction of 23% can be achieved. Again, bell-shaped PSFs show a better tradeoff between noise and resolution for a given dose than rectangular-shaped PSFs. The general interpretation of our results is that the degree of freedom of choosing the weighting or interpolation function for a given resolution is large for small detectors and small for large detectors. Thus systems with small g have a higher potential of optimization compared

  7. Factors Affecting The Adoption Of Mhealth In Maternal Health Care In Nakuru Provincial General Hospital

    Directory of Open Access Journals (Sweden)

    Simon Munyua

    2015-08-01

    Full Text Available Abstract Access to timely and quality maternal health care remains to be a major development challenge in many developing economies particularly in Kenya. The countrys system of providing maternal health care also continue to be anchored on conventional methods of physical presence of the patient and the doctor in a hospital setup. The countrys ICT and health policies also place very little emphasis on the use of these platforms. This study therefore sought to establish the factors affecting the adoption of mHealth by focusing on maternal health in Nakuru Provincial General Hospital. Objectives of the study were to determine the extent to knowledge and awareness affects the adoption of mHealth in maternal health care at Nakuru PGH to identify the government policies affecting the adoption of mHealth in maternal health care at Nakuru PGH to assess how access to technology affects the adoption of mHealth in maternal healthcare to establish the effects of ICT infrastructure on the adoption of mHealth in maternal health care and to identify the cost aspects affecting the adoption of mHealth in maternal health care at Nakuru Provincial General Hospital. It is envisaged that the study could provide useful information on the adoption of mHealth in managing maternal health care in Nakuru Provincial General Hospital. Descriptive survey research design will be used where all the medical staff and patients of Nakuru Provincial General Hospital was surveyed. The study population therefore was made up of 24 medical staff and 3460 mothers visiting the antenatal clinic selected using clustered random sampling technique. The main instrument for primary data collection was the questionnaire. Data analysis was then done using both descriptive and inferential statistics. Descriptive statistics to be used include frequency counts percentages and measures of central tendency. Inferential statistics on the other hand include t-test analysis and spearman correlation

  8. 2007Fairs & Exhibitions in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The 6th China (Guangzhou) International Seasoning Exhibition Date: May 11-13 Founded in: 2003.05 Venues: Guangzhou Int'l Convention &Exhibition Center (Pazhou) Exhibits: Seasonings, food additives, relevant material,equipment, service and publications

  9. 2005 Fairs & Exhibitions in China

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Harbin China International Winter Goods Exhibition DATE: Jan. 5-9 FREQUENCY: Annual FOUNDED TIME: Dec. 2001 VENUE: Harbin China International Conference & Exhibition Center EXHIBITS: winter sports goods and outdoor devices

  10. Nonadherence to antihypertensive medications and associated factors in general medicine clinics

    Directory of Open Access Journals (Sweden)

    Al Ghobain M

    2016-08-01

    Full Text Available Mohammed Al Ghobain,1,2 H Alhashemi,1,2 A Aljama,3 S Bin Salih,1,2 Z Assiri,4 A Alsomali,4 Gamal Mohamed5 1Department of Medicine, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, 2King Abdullah International Medical Research Centre, 3Department of Medicine, King Abdulaziz Medical City, 4College of Nursing, 5College of Public Health, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia Objectives: Nonadherence to antihypertensive medications has not been assessed in the Saudi population. The aim of this study was to address and evaluate the magnitude of nonadherence among hypertensive patients and the risk factors associated with it. Methods: A cross-sectional survey was conducted on hypertensive patients who attended the general internal medicine clinics at King Abdulaziz Medical City, Riyadh, Saudi Arabia, using a questionnaire that was modified after reviewing the literature. Hypertensive patients were labeled as nonadherent if they missed their medications for a total of 7 days during the previous month. Results: A total of 302 patients participated in the study, of whom 63% were females with a mean age of 64 years, and 64% were illiterate. The prevalence of nonadherence to medications among hypertensive patients was found to be 12.3%. Poor disease knowledge was reported in 80% of patients, while 66% of the patients had poor monitoring of their disease. Younger age (≤65 years, poor monitoring, and uncontrolled blood pressure (BP ≥140/90 mmHg were the predictor factors associated with nonadherence (odds ratio [OR] =2.04, P=0.025; OR=2.39, P=0.004; and OR=2.86, P=0.003, respectively. Conclusion: Nonadherence to antihypertensive medications is lower than that previously reported in the literature. Younger age, uncontrolled BP, and poor monitoring are the main risk factors associated with nonadherence. Keywords: nonadherence, hypertension, Saudi Arabia, uncontrolled blood

  11. Factors associated with mothers selecting general anesthesia for lower segment caesarean section.

    Science.gov (United States)

    Holdcroft, A; Parshall, A M; Knowles, M G; Waite, K E; Morgan, B M

    1995-09-01

    The objective of the study was to investigate the sociodemographic and psychological factors which are associated with choice or refusal of regional anesthesia for lower segment Caesarean section. A semi-structured questionnaire was administered preoperatively to consecutive women presenting for elective operation at two hospital sites in the same health authority. The questionnaires were administered to 39 pregnant women by two anesthetists, one at each site. Sociodemographic and past and present obstetric and anesthetic details were obtained. The Hospital Anxiety and Depression scale and the FEAR questionnaire were used with an additional visual analog scale to assess fearfulness associated with the proposed operation. A 'panic checklist' of ten items was also constructed to identify procedures associated with feelings of panic. Ten women requested general anesthesia. These women had a similar level of anxiety to the others, but were significantly more depressed, had had more pregnancies overall and more without live babies. There were also more aspects of the procedure at which they thought they might panic. Women who have suffered the loss of a conception with its associated grief and often obstetric intervention are more reluctant to be conscious during an operative delivery for a subsequent baby. Preventive measures should be considered at the time of fetal loss to avoid this. However, preoperatively a simple visual analog scale for fearfulness would identify these women so that any unresolved fears could receive full psychological assessment.

  12. Rates and risk factors of unplanned 30-day readmission following general and thoracic pediatric surgical procedures.

    Science.gov (United States)

    Polites, Stephanie F; Potter, Donald D; Glasgow, Amy E; Klinkner, Denise B; Moir, Christopher R; Ishitani, Michael B; Habermann, Elizabeth B

    2017-08-01

    Postoperative unplanned readmissions are costly and decrease patient satisfaction; however, little is known about this complication in pediatric surgery. The purpose of this study was to determine rates and predictors of unplanned readmission in a multi-institutional cohort of pediatric surgical patients. Unplanned 30-day readmissions following general and thoracic surgical procedures in children Pediatric. Time-dependent rates of readmission per 30 person-days were determined to account for varied postoperative length of stay (pLOS). Patients were randomly divided into 70% derivation and 30% validation cohorts which were used for creation and validation of a risk model for readmission. Readmission occurred in 1948 (3.6%) of 54,870 children for a rate of 4.3% per 30 person-days. Adjusted predictors of readmission included hepatobiliary procedures, increased wound class, operative duration, complications, and pLOS. The predictive model discriminated well in the derivation and validation cohorts (AUROC 0.710 and 0.701) with good calibration between observed and expected readmission events in both cohorts (p>.05). Unplanned readmission occurs less frequently in pediatric surgery than what is described in adults, calling into question its use as a quality indicator in this population. Factors that predict readmission including type of procedure, complications, and pLOS can be used to identify at-risk children and develop prevention strategies. III. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Prevalence and Predisposing Factors of Urinary Tract Infections among Pregnant Women in Abha General Hospital

    Directory of Open Access Journals (Sweden)

    Mona Abdullah Almushait

    2013-06-01

    Full Text Available This study aimed to assess the prevalence of urinary tract infection (UTI in pregnant women, to identify infectious agents causing the infection, and to explore relationship of specific socio–cultural factors with UTI. This study was conducted at the antenatal clinic of Abha General Hospital, Saudi Arabia from September 2012 to January 2013 on 402 pregnant Saudi women. Midstream urine sample was obtained. A urine analysis test and culture were done as well as socio-demographic data sheet was completed. Among the 402 studied pregnant women, 12.7% were affected with UTI. The main causative agent was escherichia coli(e-coli followed by staphylococci. It was found that UTI was strongly affected by the presence of previous history of reproductive tract inflammation, history of previous UTI attacks, the presence of UTI related complaints, washing and drying the perineum area, the direction of washing and drying the perineum area, frequency of changing diaper during menstruation and the average of cleaning the bathtub (P= 0.002, 0.000, 0.000, 0.000, 0.05, 0.000 and 0.002 respectively. Our study showed a significant percentage on prevalence of UTI among Saudi pregnant women.

  14. A general factor of personality from multitrait-multimethod data and cross-national twins.

    Science.gov (United States)

    Rushton, J Philippe; Bons, Trudy Ann; Ando, Juko; Hur, Yoon-Mi; Irwing, Paul; Vernon, Philip A; Petrides, K V; Barbaranelli, Claudio

    2009-08-01

    In three studies, a General Factor of Personality (GFP) was found to occupy the apex of the hierarchical structure. In Study 1, a GFP emerged independent of method variance and accounted for 54% of the reliable variance in a multitrait-multimethod assessment of 391 Italian high school students that used self-, teacher-, and parent-ratings on the Big Five Questionnaire - Children. In Study 2, a GFP was found in the seven dimensions of Cloninger's Temperament and Character Inventory as well as the Big Five of the NEO PI-R, with the GFPtci correlating r = .72 with the GFPneo. These results indicate that the GFP is practically the same in both test batteries, and its existence does not depend on being extracted using the Big Five model. The GFP accounted for 22% of the total variance in these trait measures, which were assessed in 651 pairs of 14- to 30-year-old Japanese twins. In Study 3, a GFP accounted for 32% of the total variance in nine scales derived from the NEO PI-R, the Humor Styles Questionnaire, and the Trait Emotional Intelligence Questionnaire assessed in 386 pairs of 18- to 74-year-old Canadian and U.S. twins. The GFP was found to be 50% heritable with high scores indicating openness, conscientiousness, sociability, agreeableness, emotional stability, good humor and emotional intelligence. The possible evolutionary origins of the GFP are discussed.

  15. Crew Factors in Flight Operations XV: Alertness Management in General Aviation Education Module

    Science.gov (United States)

    Rosekind, Mark R.; Co, Elizabeth L.; Neri, David F.; Oyung, Raymond L.; Mallis, Melissa M.; Cannon, Mary M. (Technical Monitor)

    2002-01-01

    Regional operations encompass a broad range of pilots and equipment. This module is intended to help all those involved in regional aviation, including pilots, schedulers, dispatchers, maintenance technicians, policy makers, and others, to understand the physiological factors underlying fatigue, how flight operations affect fatigue, and what can be done to counteract fatigue and maximize alertness and performance in their operations. The overall purpose of this module is to promote aviation safety, performance, and productivity. It is intended to meet three specific objectives: (1) to explain the current state of knowledge about the physiological mechanisms underlying fatigue; (2) to demonstrate how this knowledge can be applied to improving flight crew sleep, performance, and alertness; and (3) to offer strategies for alertness management. Aviation Safety Reporting System (ASRS) and National Transportation Safety Board (NISH) reports are used throughout this module to demonstrate that fatigue is a safety issue in the regional operations community. The appendices at the end of this module include the ASRS reports used for the examples contained in this publication, brief introductions to sleep disorders and relaxation techniques, summaries of relevant NASA publications, and a list of general readings on sleep, sleep disorders, and circadian rhythms.

  16. Factores asociados a mortalidad perinatal en el hospital general de Chiapas, México Perinatal mortality associated factors in a general hospital of Chiapas, Mexico

    Directory of Open Access Journals (Sweden)

    Leonor Rivera

    2003-12-01

    Full Text Available OBJETIVO: El objetivo del estudio es identificar factores socioeconómicos, gineco-obstétricos y del producto asociados a mortalidad perinatal. MÉTODOS: Se realizó un estudio de casos y controles pareado. Se consideró caso a los nacidos vivos o muertos que nacieron y fallecieron entre las 28 semanas de gestación a los 7 días de vida extrauterina. y control al producto nacido vivo entre las 28 semanas de gestación y los 7 días de vida extrauterina. Los datos se obtuvieron de los expedientes clínicos hospitalarios. Se estudiaron 99 casos y 197 controles. Se hizo un análisis estadístico utilizando Stata 6.0. RESULTADOS La media de edad de la madre fue de 24.82 años y del producto de 37.78 semanas de gestación. El promedio de peso del producto fue de 2,760 gramos. Los factores asociados a mortalidad perinatal fueron: ocupación del padre agricultor (RM ajustada 3,31; IC 95% 1,26-8,66; índice de riesgo obstétrico alto (RM ajustada 10,57; IC 95% 2,82-39,66, antecedente de cesárea (RM ajustada 2,75; IC 95% 1,37-5,51; cinco y más consultas prenatales (RM ajustada 4,43; IC 95% 1.86-10,54; producto pretérmino (RM ajustada 9,20; IC 95% 4,39-19,25. CONCLUSIONES: Los resultados muestran que es necesario implementar medidas de prevención y control que aseguren la identificación del riesgo en las mujeres embarazadas, con el fin de abatir la incidencia de mortalidad perinatal.OBJECTIVE: To identify socioeconomic, gynecological-obstetric and fetal factors associated with perinatal mortality. METHODS: A matched case-control study was carried out. Cases were newborns (born live or dead that were born and died between 28 weeks gestation and 7 days of life. Controls were live newborns between 28 weeks gestation and 7 days of life. A total of 99 cases and 197 controls were studied. Data were obtained from the corresponding medical charts. Statistical analysis was performed using Stata 6.0 software. RESULTS: Mean maternal age was 24.82 years and

  17. Cystamine preparations exhibit anticoagulant activity.

    Science.gov (United States)

    Aleman, Maria M; Holle, Lori A; Stember, Katherine G; Devette, Christa I; Monroe, Dougald M; Wolberg, Alisa S

    2015-01-01

    Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl)-lysyl crosslinks between proteins. Cystamine blocks transglutaminase activity and is used in vitro in human samples and in vivo in mice and rats in studies of coagulation, immune dysfunction, and inflammatory disease. These studies have suggested cystamine blocks fibrin crosslinking and has anti-inflammatory effects, implicating transglutaminase activity in the pathogenesis of several diseases. We measured the effects of cystamine on fibrin crosslinking, tissue factor-triggered plasma clot formation and thrombin generation, and coagulation factor enzymatic activity. At concentrations that blocked fibrin crosslinking, cystamine also inhibited plasma clot formation and reduced thrombin generation. Cystamine inhibited the amidolytic activity of coagulation factor XI and thrombin towards chromogenic substrates. These findings demonstrate that cystamine exhibits anticoagulant activity during coagulation. Given the close relationship between coagulation and inflammation, these findings suggest prior studies that used cystamine to implicate transglutaminase activity in disease pathogenesis warrant re-examination.

  18. Cystamine preparations exhibit anticoagulant activity.

    Directory of Open Access Journals (Sweden)

    Maria M Aleman

    Full Text Available Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl-lysyl crosslinks between proteins. Cystamine blocks transglutaminase activity and is used in vitro in human samples and in vivo in mice and rats in studies of coagulation, immune dysfunction, and inflammatory disease. These studies have suggested cystamine blocks fibrin crosslinking and has anti-inflammatory effects, implicating transglutaminase activity in the pathogenesis of several diseases. We measured the effects of cystamine on fibrin crosslinking, tissue factor-triggered plasma clot formation and thrombin generation, and coagulation factor enzymatic activity. At concentrations that blocked fibrin crosslinking, cystamine also inhibited plasma clot formation and reduced thrombin generation. Cystamine inhibited the amidolytic activity of coagulation factor XI and thrombin towards chromogenic substrates. These findings demonstrate that cystamine exhibits anticoagulant activity during coagulation. Given the close relationship between coagulation and inflammation, these findings suggest prior studies that used cystamine to implicate transglutaminase activity in disease pathogenesis warrant re-examination.

  19. Factors associated with visceral fat accumulation in the general population in Okinawa, Japan

    Institute of Scientific and Technical Information of China (English)

    Shingo Arakaki; Tatsuji Maeshiro; Akira Hokama; Kunikazu Hoshino; Shuichi Maruwaka; Miwa Higashiarakawa; Gretchen Parrott; Tetsuo Hirata; Kozen Kinjo; Jiro Fujita

    2016-01-01

    AIM:To investigate the clinical and biochemical factors associated with visceral fat accumulation in the general population.METHODS:We enrolled 1004 subjects who underwent a medical health checkup between April 2008 and March 2009.The medical health checkup included the following tests:Height,body weight,waist circumference(WC),systolic blood pressure,diastolic blood pressure,urinalysis,blood-cell counts,blood chemistry,electrocardiography,chest radiography,and abdominal computed tomography(CT)for visceral fat accumulation.The patients’medical history and lifestyle factors were collected privately by nurses using a selfadministered questionnaire,and they included questions regarding physical activity,sleep duration,dietary habits,smoking,and alcohol consumption.visceral fat area(VFA)was defined as the sum of the intraperitoneal fat area at the level of the umbilicus with CT density in the range of-150 to-50 Hounsfield units.RESULTS:The mean age and body mass index(BMI)of the study subjects were 57.0 years and 24.4 kg/m2.In both male and females,v FA was significantly andpositively correlated with WC(r=0.532,P<0.01;r=0.612,P<0.01).Subjects with high levels of v FA were primarily male with significantly higher age,height,body weight,BMI,systolic blood pressure(BP),diastolic BP,and hemoglobin in all subjects(P<0.05).A multivariate logistic regression analysis revealed that vF A had a positive relationship with age≥56,BMI≥25 kg/m2,and triglyceride level≥149 in males(P<0.05),whereas it had a positive relationship with age≥58,BMI≥24.4 kg/m2,high-density lipoprotein cholesterol level<40 mg/d L,and current drinking in females(P<0.05).CONCLUSION:These results suggest that gender differences exist in the clinical and biochemical parameters associated with visceral fat accumulation.

  20. The Speaking Voice in the General Population: Normative Data and Associations to Sociodemographic and Lifestyle Factors.

    Science.gov (United States)

    Berg, Martin; Fuchs, Michael; Wirkner, Kerstin; Loeffler, Markus; Engel, Christoph; Berger, Thomas

    2017-03-01

    Normative data concerning the speaking voice in the general population were gathered with the aim to establish standard values for clinical diagnostics. Associations between the speaking voice and sociodemographic factors were examined. This is a prospective cross-sectional population-based study. Speaking voice profiles were measured for 2472 (1154 male and 1318 female) participants between the ages of 40 and 79 years, using four speaking voice intensity levels: softest speaking voice (I), conversational voice (II), classroom voice (III), and shouting voice (IV). Smoking status and socioeconomic status were assessed. Data were analyzed using multivariate regression. The mean voice frequencies were 111.8 Hz for male and 161.3 Hz for female participants (I), 111.9 Hz for male and 168.5 Hz for female participants (II), 130.2 Hz for male and 198.0 Hz for female participants (III), and 175.5 Hz for male and 246.2 Hz for female participants (IV). Frequencies increased significantly with age for male but not for female participants. Sound pressure levels rose significantly with age at intensity levels I-III for both sexes, but decreased at intensity level IV. Frequencies and sound pressure levels were similar between nonsmokers and former smokers. Current smokers showed significantly lower frequencies as opposed to non- and former smokers. Speaking voice range and dynamics increased with higher socioeconomic status. The data are suitable as age-adjusted normative values for clinical measurement of the speaking voice. The mean fundamental speaking voice frequency of female participants was six to seven semitones lower than previously described. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  1. Testing general relativity with compact coalescing binaries: comparing exact and predictive methods to compute the Bayes factor

    CERN Document Server

    Del Pozzo, Walter; Mandel, Ilya; Vecchio, Alberto

    2014-01-01

    The second generation of gravitational-wave detectors is scheduled to start operations in 2015. Gravitational-wave signatures of compact binary coalescences could be used to accurately test the strong-field dynamical predictions of general relativity. Computationally expensive data analysis pipelines, including TIGER, have been developed to carry out such tests. As a means to cheaply assess whether a particular deviation from general relativity can be detected, Cornish et al. and Vallisneri recently proposed an approximate scheme to compute the Bayes factor between a general-relativity gravitational-wave model and a model representing a class of alternative theories of gravity parametrised by one additional parameter. This approximate scheme is based on only two easy-to-compute quantities: the signal-to-noise ratio of the signal and the fitting factor between the signal and the manifold of possible waveforms within general relativity. In this work, we compare the prediction from the approximate formula agains...

  2. The center for epidemiologic studies depression scale: support for a bifactor model with a dominant general factor and a specific factor for positive affect.

    Science.gov (United States)

    Gomez, Rapson; McLaren, Suzanne

    2015-06-01

    For the Center for Epidemiologic Studies Depression Scale (CES-D) ratings, the study examined support for a bifactor model, and also the internal consistency reliability and external validity of the factors in this model. Participants (N = 1,178) were older adults from the general community who completed the CES-D. Confirmatory factor analysis of their ratings indicated support for the bifactor model. For this model, the general factor explained most of the covariance in the scores of the CES-D items for Depressed Affect, Somatic Symptoms and Retarded Activity, and Interpersonal Difficulties items. Most of the covariance in the scores of the Positive Affect (PA) scale was explained by its own specific factor. Additional analyses showed support for internal consistencies and external validities of general factors based on all the CES-D items, and when PA items were excluded, and also the PA-specific factor. The findings support the use of a total CES-D score without the PA items and also the concurrent use of the PA scale score. © The Author(s) 2014.

  3. Effect of Daylight on Melatonin and Subjective General Health Factors in Elderly People

    OpenAIRE

    Zohre KARAMI; GOLMOHAMMADI, Rostam; HEIDARIPAHLAVIAN, Ahmad; Poorolajal, Jalal; HEIDARIMOGHADAM, Rashid

    2016-01-01

    Background: This paper investigated the effect of daylight on morning and night melatonin, subjective general health using GHQ questionnaire, sleepiness and alertness on elderly who lived in nursing houses.Methods: Nineteen nursing home residents participated voluntarily. They exposed to daylight from 9 to 10 a.m. and from 4 to 5 p.m. for 6 wk. The level of melatonin in the morning and at night was measured. General health of all participants was evaluated using General Health Questionnaire (...

  4. Factors Affecting the Integration of Information Literacy in the Teaching and Learning Processes of General Education Courses

    Directory of Open Access Journals (Sweden)

    Therdsak Maitaouthong

    2011-11-01

    Full Text Available This article presents the factors affecting the integration of information literacy in the teaching and learning processes of general education courses at an undergraduate level, where information literacy is used as a tool in the student-centered teaching approach. The research was divided into two phases: (1 The study of factors affecting at a policy level – a qualitative research method conducted through an in-depth interview of the vice president for academic affairs and the Director of the General Education Management Center, and (2 The survey of factors affecting in the teaching and learning processes, which is concluded through the questioning of lecturers of general education courses, and librarians. The qualitative data was analyzed on content, and the quantitative data was analyzed through the use of descriptive statistics, weight of score prioritization and percentage. Two major categories were found to have an impact on integrating information literacy in the teaching and learning of general education courses at an undergraduate level. (1 Six factors at a policy level, namely, institutional policy, administrative structure and system, administrators’ roles, resources and infrastructures, learning resources and supporting programs, and teacher evaluation and development. (2 There are eleven instructional factors: roles of lecturers, roles of librarians, roles of learners, knowledge and understanding of information literacy of lecturers and librarians, cooperation between librarians and lecturers, learning outcomes, teaching plans, teaching methods, teaching activities, teaching aids, and student assessment and evaluation.

  5. 22nd September 2010 - Korean Minister of Education, Science and Technology J.-H. Lee signing the guest book and exchanging gifts with CERN Director-General R. Heuer and Head of International Relations F. Pauss; visiting ALICE exhibition with Collaboration Spokesperson J. Schukraft; accompanied throughout by Adviser R. Voss.

    CERN Multimedia

    Teams : M. Brice ; JC Gadmer

    2010-01-01

    22nd September 2010 - Korean Minister of Education, Science and Technology J.-H. Lee signing the guest book and exchanging gifts with CERN Director-General R. Heuer and Head of International Relations F. Pauss; visiting ALICE exhibition with Collaboration Spokesperson J. Schukraft; accompanied throughout by Adviser R. Voss.

  6. 15 January 2010 - Vice-Chancellor & Chief Executive C. Snowden, University of Surrey, United Kingdom and Mrs Snowden visiting ALICE exhibition and experimental undeground area with Collabortion Spokesperson J. Schukraft and Beams Department Head P. Collier; Signature of the guest book with CERN Director-General R. Heuer.

    CERN Multimedia

    Maximilien Brice

    2010-01-01

    15 January 2010 - Vice-Chancellor & Chief Executive C. Snowden, University of Surrey, United Kingdom and Mrs Snowden visiting ALICE exhibition and experimental undeground area with Collabortion Spokesperson J. Schukraft and Beams Department Head P. Collier; Signature of the guest book with CERN Director-General R. Heuer.

  7. Tuesday 28 January 2014 - K. E. Huthmacher Ministerialdirektor Provision for the Future - Basic and Sustainability Research Federal Ministry of Education and Research (BMBF) visiting the stands with R. Heuer CERN Director-General on the occasion of the Inauguration of the Industrial Exhibition Germany@CERN and visiting the ATLAS Cavern with D. Charlton ATLAS Collaboration Spokesperson and R. Voss Head of International Relations.

    CERN Multimedia

    Pantelia, Anna

    2014-01-01

    Tuesday 28 January - K. E. Huthmacher Ministerialdirektor Provision for the Future - Basic and Sustainability Research Federal Ministry of Education and Research (BMBF) visiting the stands with R. Heuer CERN Director-General on the occasion of the Inauguration of the Industrial Exhibition Germany@CERN and visiting the ATLAS Cavern with D. Charlton ATLAS Collaboration Spokesperson and R. Voss Head of International Relations.

  8. Electric and Weak Electric Dipole Form Factors for Heavy Fermions in a General Two Higgs Doublet Model

    CERN Document Server

    Gómez-Dumm, D; Gomez-Dumm, Daniel

    1999-01-01

    The electric and weak electric dipole form factors for heavy fermions are calculated in the context of the most general two-Higgs-doublet model (2HDM). We find that the large top mass can produce a significant enhancement of the electric dipole form factor in the case of the b and c quarks. This effect can be used to distinguish between different 2HDM scenarios.

  9. Prevalence and risk factors for developing posttraumatic stress disorder in a general intensive care population - a literature review

    OpenAIRE

    Nilsen, Cecilie Bræin

    2016-01-01

    Aim: 1) To investigate prevalence of posttraumatic stress disorder (PTSD) and symptoms of posttraumatic stress (PTSS) in a general intensive care patient population, and risk factors for post ICU-PTSD/PTSS. 2) To investigate how instruments and loss to follow-up could influence the prevalence of PTSD/PTSS in this patient population. Background: Studies have found a wide variance of PTSD/PTSS in this patient population. A number of risk factors were associated with developing post-ICU ...

  10. Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II.

    Science.gov (United States)

    Sopta, M; Burton, Z F; Greenblatt, J

    1989-10-05

    RAP30/74 is a heteromeric general transcription initiation factor which binds to RNA polymerase II. Here we report that preparations of RAP30/74 contain an ATP-dependent DNA helicase whose probable function is to melt the DNA at transcriptional start sites. The sequence of the RAP30 subunit of RAP30/74 indicates that RAP30 may be distantly related to bacterial sigma factors.

  11. Crows spontaneously exhibit analogical reasoning.

    Science.gov (United States)

    Smirnova, Anna; Zorina, Zoya; Obozova, Tanya; Wasserman, Edward

    2015-01-19

    Analogical reasoning is vital to advanced cognition and behavioral adaptation. Many theorists deem analogical thinking to be uniquely human and to be foundational to categorization, creative problem solving, and scientific discovery. Comparative psychologists have long been interested in the species generality of analogical reasoning, but they initially found it difficult to obtain empirical support for such thinking in nonhuman animals (for pioneering efforts, see [2, 3]). Researchers have since mustered considerable evidence and argument that relational matching-to-sample (RMTS) effectively captures the essence of analogy, in which the relevant logical arguments are presented visually. In RMTS, choice of test pair BB would be correct if the sample pair were AA, whereas choice of test pair EF would be correct if the sample pair were CD. Critically, no items in the correct test pair physically match items in the sample pair, thus demanding that only relational sameness or differentness is available to support accurate choice responding. Initial evidence suggested that only humans and apes can successfully learn RMTS with pairs of sample and test items; however, monkeys have subsequently done so. Here, we report that crows too exhibit relational matching behavior. Even more importantly, crows spontaneously display relational responding without ever having been trained on RMTS; they had only been trained on identity matching-to-sample (IMTS). Such robust and uninstructed relational matching behavior represents the most convincing evidence yet of analogical reasoning in a nonprimate species, as apes alone have spontaneously exhibited RMTS behavior after only IMTS training. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Gaïa Manuella Cany Du 10 au 28 avril 2017 CERN Meyrin, Bâtiment principal Oiseau - Manuella Cany. Tableaux abstraits inspirés de vues satellites ou photos prises du ciel. Certains sont à la frontière du figuratif alors que d'autres permettent de laisser libre cours à son imagination. Aux détails infinis, ces tableaux sont faits pour être vus de loin et de près grâce à une attention toute particulière apportée aux effets de matières et aux couleurs le long de volutes tantôt nuancées tantôt contrastées.   Pour plus d’informations : staff.association@cern.ch | Tél: 022 766 37 38

  13. Exhibition

    CERN Multimedia

    Staff Association

    2014-01-01

      Parallels vision Astronomical subjects which evoke extrasensory kinetic visions Alberto Di Fabio From 8 to 10 October, CERN Meyrin, Main Building In the framework of Italy@cern, the Staff Association presents Alberto Di Fabio. Di Fabio’s work is inspired by the fundamental laws of the physical world, as well as organic elements and their interrelation. His paintings and works on paper merge the worlds of art and science, depicting natural forms and biological structures in vivid colour and imaginative detail. For all additional information: staff.association@cern.ch | Tel: 022 767 28 19

  14. Exhibition

    CERN Multimedia

    Staff Association

    2011-01-01

    Jan Hladky, physicien de l'Institut de Physique de l'Académie des Sciences de la République tchèque, et membre de la collaboration Alice, expose ses œuvres au Bâtiment principal du 20 avril au 6 mai. Son exposition est dédiée aux victimes du séisme de Sendai. Des copies de ses œuvres seront mises en vente et les sommes récoltées seront versées au profit des victimes.

  15. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    The Elementary Particles of Painting Alfonso Fratteggiani Bianchi and Ermanno Imbergamo From September 26 to October 7, 2016 CERN Meyrin, Main Building With intentions similar to those of CERN physicists, the artist Alfonso Fratteggiani Bianchi investigates the color pigment, studying its interaction with light and with the support on which it is deposited. He creates monochrome paintings by spreading the color pigment in the pure state on stones, without using glue or any other type of adhesive. With intentions similar to artists, the physicist Ermanno Imbergamo investigates the use of luminescent wavelength shifters, materials commonly used in Particle Physics, for art. He creates other monochrome artworks, which disclose further aspects of interaction among light, color pigments and support. For more information: staff.association@cern.ch | Tel: 022 767 28 19

  16. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    La mosaïque ou quand détruire permet de construire Lauren Decamps Du 28 novembre au 9 décembre 2016 CERN Meyrin, Bâtiment principal Paysage d'Amsterdam - Lauren Decamps On ne doit jamais rien détruire qu'on ne soit sûr de pouvoir remplacer aussi avantageusement " écrivait Plutarque dans ses Œuvres morales du 1er siècle après JC. L'artiste mosaïste Lauren Decamps adhère à cette idée et tente à sa manière de donner une nouvelle vie à ses matériaux en les taillant puis les réassemblant, créant ainsi des œuvres abstraites et figuratives.

  17. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Le Point Isabelle Gailland Du 20 février au 3 mars 2017 CERN Meyrin, Bâtiment principal La Diagonale - Isabelle Gailland. Au départ, un toujours même point minuscule posé au centre de ce que la toile est un espace. Une réplique d'autres points, condensés, alignés, isolés, disséminés construiront dans leur extension, la ligne. Ces lignes, croisées, courbées, déviées, prolongées, seront la structure contenant et séparant la matière des couleurs. La rotation de chaque toile en cours d'exécution va offrir un accès illimité à la non-forme et à la forme. Le point final sera l'ouverture sur différents points de vue de ce que le point et la ligne sont devenus une représentation pour l'œil et l'im...

  18. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    COLORATION Sandra Duchêne From September 5 to 16, 2016 CERN Meyrin, Main Building La recherche de l’Universel. Après tout ! C’est de l’Amour ! What else to say ? …La couleur, l’ENERGIE de la vie…

  19. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Œuvres recentes Fabienne Wyler Du 6 au 17 février 2017 CERN Meyrin, Bâtiment principal L'escalier du diable B - aquarelle, encre de Chine XLV - Fabienne Wyler. En relation avec certains procédés d’écriture contemporaine (par ex. Webern ou certaines musiques conçues par ordinateur), les compositions picturales de Fabienne Wyler s’élaborent à partir de « modules » (groupes de quadrangles) qu’elle reproduit en leur faisant subir toutes sortes de transformations et de déplacements : étirements, renversements, rotations, effet miroir, transpositions, déphasages, superpositions, etc., et ceci à toutes les échelles. Au fil des œuvres sont apparues des séries intitulées, Bifurcations, Intermittences, Attracteurs étranges, Polyrythmies. Ces titres ont un lien &e...

  20. Exhibition

    CERN Multimedia

    Staff Association

    2014-01-01

    Energie sombre, matière noire J.-J. Dalmais - J. Maréchal Du 11 au 27 novembre 2014, CERN Meyrin, Bâtiment principal A l’image des particules atomiques qui ont tissé des liens pour créer la matière, deux artistes haut bugistes croisent leurs regards et conjuguent leurs expressions singulières pour faire naître une vision commune de l’univers, produit des forces primordiales. Les sculptures de Jean-Jacques Dalmais et les peintures de Jacki Maréchal se rencontrent pour la première fois et se racontent par un enrichissement mutuel la belle histoire de la Vie. Dialogue magique des œuvres en mouvement qui questionnent en écho l’énergie sombre et la matière noire. Cette harmonieuse confluence de jeux de miroir et de résonnance illumine de poésie et de sobriété l’espace expos&...

  1. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Harmonie Nathalie Lenoir Du 4 au 15 septembre 2017 CERN Meyrin, Bâtiment principal Peindre est un langage. Le tracé du pinceau sur le lin en est l'expression. A qui appartient un tableau en définitive ? A celui qui l'a peint ? A celui qui le regarde ? A celui qui l'emporte ? La peinture est une émotion partagée... Laissez-vous projeter de l'autre côté de la toile, prenez un moment pour rêver, en harmonie avec les éléments, parce-que la peinture parle à votre âme… Pour plus d’informations et demandes d’accès : staff.association@cern.ch | Tél : 022 766 37 38

  2. Exhibition

    CERN Document Server

    Staff Association

    2017-01-01

    Firmament des toiles Joëlle Lalagüe Du 6 au 16 juin 2017 CERN Meyrin, Bâtiment principal Phylaë Voyage - Joëlle Lalagüe. Each picture is an invitation for a cosmic trip. This is a whispering of soul, which comes from origins. A symphony of the world, some notes of love, a harmony for us to fly to infinity. Pour plus d’informations et demandes d'accès : staff.association@cern.ch | Tél: 022 766 37 38

  3. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    La couleur des jours oriSio Du 2 au 12 mai 2017 CERN Meyrin, Bâtiment principal oriSio - Motus Suite à un fort intérêt pour la Chine et une curiosité pour un médium très ancien, la laque ! Je réinterprète cet art à travers un style abstrait. Je présente ici des laques sur aluminium, travaillés au plasma et ensuite colorés à l’aide de pigments pour l’essentiel. Mes œuvres je les veux brutes, déchirées, évanescentes, gondolées, voire trouées mais avec une belle approche de profondeur de la couleur.   Pour plus d’informations : staff.association@cern.ch | Tél: 022 766 37 38

  4. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    La mosaïque ou quand détruire permet de construire Lauren Decamps Du 28 novembre au 9 décembre 2016 CERN Meyrin, Bâtiment principal Paysage d'Amsterdam - Lauren Decamps On ne doit jamais rien détruire qu'on ne soit sûr de pouvoir remplacer aussi avantageusement " écrivait Plutarque dans ses Œuvres morales du 1er siècle après JC. L'artiste mosaïste Lauren Decamps adhère à cette idée et tente à sa manière de donner une nouvelle vie à ses matériaux en les taillant puis les réassemblant, créant ainsi des œuvres abstraites et figuratives.

  5. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Still Life Jérémy Bajulaz Du 25 septembre au 6 octobre 2017 CERN Meyrin, Main Building (Aubergine - Jérémy Bajulaz) Né en 1991 en Haute-Savoie, France. Diplômé de l'Ecole Emile Cohl à Lyon, Jérémy Bajulaz intègre en 2014 le programme d'artiste en résidence au Centre Genevois de Gravure Contemporaine. C'est là que son travail prendra corps, autour de la lumière et de ses vibrations aux travers de sujets comme le portrait et la nature morte, dans le souci de l'observation; le regard prenant une place importante dans le processus créatif. Lauréat 2017 du VII Premio AAAC, son travail a été présenté dans de nombreuses expositions collectives, en 2015 au Bâtiment d’Art Contemporain de Genève, en 2016 au 89e Salon de Lyon et du S...

  6. A Comprehensive Test of General Strain Theory: Key Strains, Situational- and Trait-Based Negative Emotions, Conditioning Factors, and Delinquency

    Science.gov (United States)

    Moon, Byongook; Morash, Merry; McCluskey, Cynthia Perez; Hwang, Hye-Won

    2009-01-01

    Using longitudinal data on South Korean youth, the authors addressed limitations of previous tests of general strain theory (GST), focusing on the relationships among key strains, situational- and trait-based negative emotions, conditioning factors, and delinquency. Eight types of strain previously shown most likely to result in delinquency,…

  7. The prevalence of risk factors for general recidivism in female adolescent sexual offenders: A comparison of three subgroups

    NARCIS (Netherlands)

    van der Put, C.E.

    2013-01-01

    To our knowledge, there are no former studies in which subgroups of female adolescent sexual offenders are studied. Therefore, we examined differences in risk factors for general recidivism between female adolescents who have committed a felony sexual offense against a younger child (CSO, n = 25),

  8. The prevalence of risk factors for general recidivism in female adolescent sexual offenders: A comparison of three subgroups

    NARCIS (Netherlands)

    van der Put, C.E.

    2013-01-01

    To our knowledge, there are no former studies in which subgroups of female adolescent sexual offenders are studied. Therefore, we examined differences in risk factors for general recidivism between female adolescents who have committed a felony sexual offense against a younger child (CSO, n = 25), f

  9. Self-Control, Social Factors, and Delinquency: A Test of the General Theory of Crime among Adolescents in Hong Kong

    Science.gov (United States)

    Cheung, Nicole W. T.; Cheung, Yuet W.

    2008-01-01

    The objectives of this study were to test the predictive power of self-control theory for delinquency in a Chinese context, and to explore if social factors as predicted in social bonding theory, differential association theory, general strain theory, and labeling theory have effects on delinquency in the presence of self-control. Self-report data…

  10. Stability of Posttraumatic Stress Reaction Factors and Their Relation to General Mental Health Problems in Children: A Longitudinal Study

    Science.gov (United States)

    Nygaard, Egil; Jensen, Tine K.; Dyb, Grete

    2012-01-01

    The aim of this study was to evaluate the structure of posttraumatic stress reaction factors and their relation to general mental health problems in Norwegian children exposed to the tsunami on December 26, 2004. A total of 133 children and adolescents (ages 6-17) were interviewed 10 months posttsunami using the UCLA PTSD Reaction Index, and 104…

  11. At risk, or not at risk: Epidemiological approaches for assessing psychiatric (genetic) risk factors in the general population

    NARCIS (Netherlands)

    Breetvelt, E.J.

    2013-01-01

    This thesis “At risk, or not at risk” describes several approaches - cross-sectional, prospective, phenotype mining and forward genetics - for assessing psychiatric (genetic) risk factors in a general population study. The aims were 1) to investigate how routine and follow-up data from populationbas

  12. Factors Associated with General and Sexual Alcohol-Related Consequences: An Examination of College Students Studying Abroad

    Science.gov (United States)

    Hummer, Justin F.; Pedersen, Eric R.; Mirza, Tehniat; LaBrie, Joseph W.

    2010-01-01

    This study contributes to the scarce research on U.S. college students studying abroad by documenting general and sexual negative alcohol-related risks and factors associated with such risk. The manner of drinking (quantity vs. frequency), pre-departure expectations surrounding alcohol use while abroad, culture-related social anxiety, and…

  13. The prevalence of risk factors for general recidivism in female adolescent sexual offenders: A comparison of three subgroups

    NARCIS (Netherlands)

    van der Put, C.E.

    2013-01-01

    To our knowledge, there are no former studies in which subgroups of female adolescent sexual offenders are studied. Therefore, we examined differences in risk factors for general recidivism between female adolescents who have committed a felony sexual offense against a younger child (CSO, n = 25), f

  14. Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia.

    Science.gov (United States)

    Shah, Dania A; Khalil, Raouf A

    2015-06-15

    Preeclampsia is a pregnancy-associated disorder characterized by hypertension, and could lead to maternal and fetal morbidity and mortality; however, the pathophysiological mechanisms involved are unclear. Predisposing demographic, genetic and environmental risk factors could cause localized abnormalities in uteroplacental cytoactive factors such as integrins, matrix metalloproteinases, cytokines and major histocompatibility complex molecules leading to decreased vascular remodeling, uteroplacental vasoconstriction, trophoblast cells apoptosis, and abnormal development of the placenta. Defective placentation and decreased trophoblast invasion of the myometrium cause reduction in uteroplacental perfusion pressure (RUPP) and placental ischemia/hypoxia, an important event in preeclampsia. RUPP could stimulate the release of circulating bioactive factors such as the anti-angiogenic factors soluble fms-like tyrosine kinase-1 and soluble endoglin that cause imbalance with the pro-angiogenic factors vascular endothelial growth factor and placental growth factor, or cause the release of inflammatory cytokines, reactive oxygen species, hypoxia-induced factor-1 and AT1 angiotensin receptor agonistic autoantibodies. The circulating bioactive factors target endothelial cells causing generalized endotheliosis, endothelial dysfunction, decreased vasodilators such as nitric oxide and prostacyclin and increased vasoconstrictors such as endothelin-1 and thromboxane A2, leading to increased vasoconstriction. The bioactive factors also stimulate the mechanisms of VSM contraction including Ca(2+), protein kinase C, and Rho-kinase and induce extracellular matrix remodeling leading to further vasoconstriction and hypertension. While therapeutic options are currently limited, understanding the underlying mechanisms could help design new interventions for management of preeclampsia.

  15. Evaluation of Effective Factors on the Clinical Performance of General Surgeons in Tehran University of Medical Science, 2015

    Science.gov (United States)

    Farzianpour, Fereshteh; Mohamadi, Efat; najafpour, Zhila; Yousefinezhadi, Taraneh; Forootan, Sara; Foroushani, Abbas Rahimi

    2016-01-01

    Background and Objective: Existence of doctors with high performance is one of the necessary conditions to provide high quality services. There are different motivations, which could affect their performance. Recognizing Factors which effect the performance of doctors as an effective force in health care centers is necessary. The aim of this article was evaluate the effective factors which influence on clinical performance of general surgery of Tehran University of Medical Sciences in 2015. Methods: This is a cross-sectional qualitative-quantitative study. This research conducted in 3 phases-phases I: (use of library studies and databases to collect data), phase II: localization of detected factors in first phase by using the Delphi technique and phase III: prioritizing the affecting factors on performance of doctors by using qualitative interviews. Results: 12 articles were analyzed from 300 abstracts during the evaluation process. The output of assessment identified 23 factors was sent to surgeons and their assistants for obtaining their opinions. Quantitative analysis of the findings showed that “work qualification” (86.1%) and “managers and supervisors style” (50%) have respectively the most and the least impact on the performance of doctors. Finally 18 effective factors were identified and prioritized in the performance of general surgeons. Conclusion: The results showed that motivation and performance is not a single operating parameter and it depends on several factors according to cultural background. Therefore it is necessary to design, implementation and monitoring based on key determinants of effective interventions due to cultural background. PMID:27157161

  16. Spiritual values of heads of general education institutions as a factor of professional crises’ overcoming

    Directory of Open Access Journals (Sweden)

    Алла Степанівна Москальова

    2015-12-01

    Full Text Available The article is devoted to the important problem of psychology – the research of the spiritual values of heads of general education institutions. The content and indicators of development of spiritual values of managers are determined. The results of empirical research levels of spiritual values of managers are presented. It has been proved correlation between the levels of development of spiritual values of heads of general education institutions and their ability to overcome professional crises

  17. A factorization result for generalized Nevanlinna functions of the class N-k

    NARCIS (Netherlands)

    Dijksma, A; Langer, H; Luger, A; Shondin, Y

    2000-01-01

    Let Q is an element of N-kappa. It is shown that if alpha is a nonreal pole or a real generalized pole of nonpositive type and beta is a nonreal zero or a real generalized zero of nonpositive type of the function Q then the function Q(1)(z) := (z-alpha)(z-)/(z-beta)(z-) Q(z) belongs to the class Nka

  18. The factors associated to psychosocial stress among general practitioners in Lithuania. Cross-sectional study

    Directory of Open Access Journals (Sweden)

    Vanagas Giedrius

    2005-06-01

    Full Text Available Abstract Background There are number of studies showing that general practice is one of the most stressful workplace among health care workers. Since Baltic States regained independence in 1990, the reform of the health care system took place in which new role and more responsibilities were allocated to general practitioners' in Lithuania. This study aimed to explore the psychosocial stress level among Lithuanian general practitioner's and examine the relationship between psychosocial stress and work characteristics. Methods The cross-sectional study of 300 Lithuanian General practitioners. Psychosocial stress was investigated with a questionnaire based on the Reeder scale. Job demands were investigated with the R. Karasek scale. The analysis included descriptive statistics; interrelationship analysis between characteristics and multivariate logistic regression to estimate odds ratios for each of the independent variables in the model. Results Response rate 66% (N = 197. Our study highlighted highest prevalence of psychosocial stress among widowed, single and female general practitioners. Lowest prevalence of psychosocial stress was among males and older age general practitioners. Psychosocial stress occurs when job demands are high and job decision latitude is low (χ2 = 18,9; p Conclusion One half of respondents suffering from work related psychosocial stress. High psychological workload demands combined with low decision latitude has the greatest impact to stress caseness among GP's. High job demands, high patient load and young age of GP's can be assigned as significant predictors of psychosocial stress among GP's.

  19. Science Fiction Exhibits as STEM Gateways

    Science.gov (United States)

    Robie, Samantha

    Women continue to hold less than a quarter of all STEM jobs in the United States, prompting many museums to develop programs and exhibits with the express goal of interesting young girls in scientific fields. At the same time, a number of recent museum exhibits have harnessed the popularity of pop culture and science fiction in order to interest general audiences in STEM subject matter, as well as using the exhibits as springboards to expand or shift mission goals and focus. Because science fiction appears to be successful at raising interest in STEM fields, it may be an effective way to garner the interest of young girls in STEM in particular. This research seeks to describe the ways in which museums are currently using science fiction exhibits to interest young girls in STEM fields and careers. Research focused on four institutions across the country hosting three separate exhibits, and included staff interviews and content analysis of exhibit descriptions, promotional materials, a summative evaluation and supplementary exhibit productions. In some ways, science fiction exhibits do serve young girls, primarily through the inclusion of female role models, staff awareness, and prototype testing to ensure interactives are attractive to girls as well as to boys. However, STEM appears to be underutilized, which may be partly due to a concern within the field that the outcome of targeting a specific gender could be construed as "stereotyping".

  20. Sexual life satisfaction and its associated socio-demographic and workplace factors among Chinese female nurses of tertiary general hospitals.

    Science.gov (United States)

    Ji, Feng; Jiang, Deguo; Lin, Xiaodong; Zhang, Wei; Zheng, Weifang; Cheng, Ce; Lin, Chongguang; Hu, Lirong; Zhuo, Chuanjun

    2017-08-15

    Adverse workplace factors such as job stress are reported to be associated with poor physical and mental health of nurses. However, associations between occupational factors and sexual life satisfaction (SLS) of nurses remain understudied. This study investigated SLS of Chinese female nurses of tertiary general hospitals and socio-demographic and occupational factors associated with reduced SLS of nurses. In this cross-sectional survey, 393 Chinese female nurses of four tertiary general hospitals completed a standardized socio-demographic and occupational characteristics questionnaire, Zung's Self-rating Scale for Depression, Job Content Questionnaire, and a self-report SLS question. Multiple ordinal logistic regression was used to identify factors related to reduced SLS. Fourteen point five percent female nurses were dissatisfied with their current sex lives. In multiple regression, related factors for decreased SLS included being unmarried (OR = 1.49), shift work (OR = 1.92), contract employment (OR = 1.63), high job demands (OR = 2.21), low job control (OR = 1.88), inadequate social support (OR = 2.32), and depression (OR = 3.14). Chinese female nurses of tertiary general hospitals have poor SLS. Reducing job stress and providing psycho-social support may help improve SLS of nurses.

  1. Somatic symptom reports in the general population: Application of a bi-factor model to the analysis of change.

    Science.gov (United States)

    Porsius, Jarry T; Martens, Astrid L; Slottje, Pauline; Claassen, Liesbeth; Korevaar, Joke C; Timmermans, Danielle R M; Vermeulen, Roel; Smid, Tjabe

    2015-11-01

    To investigate the latent structure of somatic symptom reports in the general population with a bi-factor model and apply the structure to the analysis of change in reported symptoms after the emergence of an uncertain environmental health risk. Somatic symptoms were assessed in two general population environmental health cohorts (AMIGO, n=14,829 & POWER, n=951) using the somatization scale of the four-dimensional symptom questionnaire (4DSQ-S). Exploratory bi-factor analysis was used to determine the factor structure in the AMIGO cohort. Multi-group and longitudinal models were applied to assess measurement invariance. For a subsample of residents living close to a newly introduced power line (n=224), we compared a uni- and multidimensional method for the analysis of change in reported symptoms after the power line was put into operation. We found a good fit (RMSEA=0.03, CFI=0.98) for a bi-factor model with one general and three symptom specific factors (musculoskeletal, gastrointestinal, cardiopulmonary). The latent structure was found to be invariant between cohorts and over time. A significant increase (pfactor structure of somatic symptoms reports was equivalent between cohorts and over time. Our findings suggest that taking this structure into account can lead to a more informative interpretation of a change in symptom reports compared to a unidimensional approach. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. Mammographic texture resemblance generalizes as an independent risk factor for breast cancer

    NARCIS (Netherlands)

    Nielsen, M.; Vachon, C.M.; Scott, C.G.; Chernoff, K.; Karemore, G.; Karssemeijer, N.; Lillholm, M.; Karsdal, M.A.

    2014-01-01

    Breast density has been established as a major risk factor for breast cancer. We have previously demonstrated that mammographic texture resemblance (MTR), recognizing the local texture patterns of the mammogram, is also a risk factor for breast cancer, independent of percent breast density. We exami

  3. Growth factor delivery-based tissue engineering: general approaches and a review of recent developments.

    Science.gov (United States)

    Lee, Kangwon; Silva, Eduardo A; Mooney, David J

    2011-02-06

    The identification and production of recombinant morphogens and growth factors that play key roles in tissue regeneration have generated much enthusiasm and numerous clinical trials, but the results of many of these trials have been largely disappointing. Interestingly, the trials that have shown benefit all contain a common denominator, the presence of a material carrier, suggesting strongly that spatio-temporal control over the location and bioactivity of factors after introduction into the body is crucial to achieve tangible therapeutic effect. Sophisticated materials systems that regulate the biological presentation of growth factors represent an attractive new generation of therapeutic agents for the treatment of a wide variety of diseases. This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives are discussed. Recent progress highlights the importance of materials science and engineering in growth factor delivery approaches to regenerative medicine.

  4. Generalized block-lifting factorization of M-channel biorthogonal filter banks for lossy-to-lossless image coding.

    Science.gov (United States)

    Suzuki, Taizo; Ikehara, Masaaki; Nguyen, Truong Q

    2012-07-01

    Generalized block-lifting factorization of M-channel (M > 2) biorthogonal filter banks (BOFBs) for lossy-to-lossless image coding is presented in this paper. Since the proposed block-lifting structure is more general than the conventional lifting factorizations and does NOT require many restrictions such as paraunitary, number of channels, and McMillan degree in each building block unlike the conventional lifting factorizations, its coding gain is higher than that of the previous methods. Several proposed BOFBs are designed and applied to image coding. Comparing the results with conventional lossy-to-lossless image coding structures, including the 5/3- and 9/7-tap discrete wavelet transforms in JPEG 2000 and a 4 × 8 hierarchical lapped biorthogonal transform in JPEG XR, the proposed BOFBs achieve better result in both objective measure and perceptual visual quality for the images with a lot of high-frequency components.

  5. Gyromagnetic factor of rotating disks of electrically charged dust in general relativity

    Science.gov (United States)

    Liu Pynn, Yu-Chun; Macedo, Rodrigo Panosso; Breithaupt, Martin; Palenta, Stefan; Meinel, Reinhard

    2016-11-01

    We calculated the dimensionless gyromagnetic ratio ("g -factor") of self-gravitating, uniformly rotating disks of dust with a constant specific charge ɛ . These disk solutions to the Einstein-Maxwell equations depend on ɛ and a "relativity parameter" γ (0 <γ ≤1 ) up to a scaling parameter. Accordingly, the g -factor is a function g =g (γ ,ɛ ). The Newtonian limit is characterized by γ ≪1 , whereas γ →1 leads to a black-hole limit. The g -factor, for all ɛ , approaches the values g =1 as γ →0 and g =2 as γ →1 .

  6. Gyromagnetic factor of rotating disks of electrically charged dust in general relativity

    CERN Document Server

    Pynn, Yu-Chun; Breithaupt, Martin; Palenta, Stefan; Meinel, Reinhard

    2016-01-01

    We calculated the dimensionless gyromagnetic ratio ("$g$-factor") of self-gravitating, uniformly rotating disks of dust with a constant specific charge $\\epsilon$. These disk solutions to the Einstein-Maxwell equations depend on $\\epsilon$ and a "relativity parameter" $\\gamma$ ($0<\\gamma\\le 1$) up to a scaling parameter. Accordingly, the $g$-factor is a function $g=g(\\gamma,\\epsilon)$. The Newtonian limit is characterized by $\\gamma \\ll 1$, whereas $\\gamma\\to 1$ leads to a black-hole limit. The $g$-factor, for all $\\epsilon$, approaches the values $g=1$ as $\\gamma\\to 0$ and $g=2$ as $\\gamma\\to 1$.

  7. Background factors in craniomandibular disorders with special reference to general joint hypermobility, parafunction, and trauma.

    Science.gov (United States)

    Westling, L; Carlsson, G E; Helkimo, M

    1990-01-01

    Seventy-four female patients referred to a CMD clinic were randomly selected for an examination of general joint mobility according to Beighton. Thirty of the patients (41%) were classified as hypermobile. Eighty-three percent of the patients with generally lax joints had TMJ involvement in comparison to 41% of the patients with no joint laxity. The difference between these groups was statistically significant (P less than 0.001). Parafunctions and trauma were associated with increased symptoms and signs in individuals with lax joints. In nonlax joint patients, trauma to the head and jaw was significantly correlated to TMJ disorders. The results indicate that general joint hypermobility should be taken into consideration in the diagnosis and treatment of CMD.

  8. Factors influencing serum total tryptase concentrations in a general adult population

    DEFF Research Database (Denmark)

    Gonzalez-Quintela, Arturo; Vizcaino, Luis; Gude, Francisco;

    2010-01-01

    Serum tryptase measurements are increasingly being used in clinical practice. However, there is a paucity of studies focused on factors that influence tryptase concentrations. We investigated the relationships between total tryptase concentrations and age, gender, atopy, alcohol consumption, smok...

  9. Factors influencing serum total tryptase concentrations in a general adult population

    DEFF Research Database (Denmark)

    Gonzalez-Quintela, Arturo; Vizcaino, Luis; Gude, Francisco;

    2010-01-01

    Serum tryptase measurements are increasingly being used in clinical practice. However, there is a paucity of studies focused on factors that influence tryptase concentrations. We investigated the relationships between total tryptase concentrations and age, gender, atopy, alcohol consumption...

  10. Identifying context factors explaining physician's low performance in communication assessment: an explorative study in general practice.

    NARCIS (Netherlands)

    Essers, G.T.J.M.; Dulmen, S. van; Weel, C. van; Vleuten, C.P.M. van der; Kramer, A.W.

    2011-01-01

    ABSTRACT: BACKGROUND: Communication is a key competence for health care professionals. Analysis of registrar and GP communication performance in daily practice, however, suggests a suboptimal application of communication skills. The influence of context factors could reveal why communication perform

  11. 32 CFR 705.24 - Exhibits.

    Science.gov (United States)

    2010-07-01

    ..., or similar events. Also included are general purpose displays in public buildings or public locations... support local Navy recruiters. Requests for exhibits for community relations events will be considered... event). (2) The office of the Assistant Secretary of Defense (Public Affairs) is the approving authority...

  12. Retrospect of China International Auto Exhibition Tours

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ "Fengfan Cup" the Frist China International Auto Exhibition Tour In 1995, the first session gathered 28 national motorcycles and autos from four big groups---China North Industries Group Corporation, China Aviation Industry Corporation, China Aerospace Science and Industry Cooperation and PLA General Logistics Department.

  13. Generalized or abdominal obesity: which one better identifies cardiometabolic risk factors among children and adolescents? The CASPIAN III study.

    Science.gov (United States)

    Ataie-Jafari, Asal; Heshmat, Ramin; Kelishadi, Roya; Ardalan, Gelayol; Mahmoudarabi, Minoosadat; Rezapoor, Aziz; Motlagh, Mohammad Esmaeil; Asayesh, Hamid; Larijani, Bagher; Qorbani, Mostafa

    2014-10-01

    We investigated the association of generalized and abdominal obesity with cardiometabolic risk factors in children and adolescents. Data were obtained from a surveillance system entitled CASPIAN-III study in school students aged 10-18 years in Iran. Data of subjects with normal body mass index (BMI) or above (BMI ≥ 5th percentile) were analyzed. The associations of obesity with cardiometabolic risk factors were tested using logistic regression models. In the sample of 4641 children and adolescents, overweight/obese children were more likely to have metabolic syndrome and cardiometabolic risk factors compared with their normal weight counterparts. Among these parameters, elevated TG had the strongest association with degree of obesity (overweight: OR = 2.28 [95% CI 1.59-3.26]; obesity: OR = 5.63 [95% CI 4.27,7.43]). Combined generalized and abdominal obesity increased the risk of high blood pressure, elevated triglyceride and total cholesterol. Combined type of generalized and abdominal obesity is a predictor of cardiometabolic risk factors. © The Author [2014]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  14. Basic Boundary Interpolation for Generalized Schur Functions and Factorization of Rational J-unitary Matrix Functions

    NARCIS (Netherlands)

    Alpay, Daniel; Dijksma, Aad; Langer, Heinz; Wanjala, Gerald

    2006-01-01

    We define and solve a boundary interpolation problem for generalized Schur functions s(z) on the open unit disk D which have preassigned asymptotics when z from D tends nontangentially to a boundary point z1 ∈ T. The solutions are characterized via a fractional linear parametrization formula. We als

  15. Quality of life and associated factors in persons with Chronic Rhinosinusitis in the general population

    DEFF Research Database (Denmark)

    Lange, B; Holst, R; Thilsing, T;

    2013-01-01

    The European Position Paper on Rhinosinusitis and Nasal Polyps describes methods to perform population-based and clinical studies on Chronic Rhinosinusitis in a standardized way and it also describes how to clinical investigate CRS. The aim of this cross sectional study was to evaluate Quality...... of life and objective findings in persons with Chronic Rhinosinusitis recruited from the general population....

  16. Quality-Shaping Factors and Endodontic Treatment amongst General Dental Practitioners with a Focus on Denmark

    DEFF Research Database (Denmark)

    Demant, Sune; Markvart, Merete; Bjørndal, Lars

    2012-01-01

    There is a gap between the endodontic outcome that can be achieved and the outcome observed on the basis of worldwide general dental practitioner data. The quality of root canal treatment (RCT) is shaped by the dentist's knowledge, attitude, and skills, but it may also be influenced by the patient...

  17. Dietary factors and lung function in the general population : wine and resveratrol intake

    NARCIS (Netherlands)

    Siedlinski, M; Boer, J M A; Smit, H A; Postma, D S; Boezen, H M

    2012-01-01

    Wine intake is associated with a better lung function in the general population, yet the source of this effect is unknown. Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, its effects being partially mediated via induction of Sirtuin (SIRT) 1 activity. We assessed the

  18. Factors associated with the risk of caries development after comprehensive dental rehabilitation under general anesthesia

    Directory of Open Access Journals (Sweden)

    Yai-Tin Lin

    2016-06-01

    Conclusion: This study has shown that SM count and CRA score were associated with new caries development in ECC children who needed to be treated under general anesthesia. The modified Cariogram used in this study is another significant tool for predicting new carries development in this particular population.

  19. Dietary factors and lung function in the general population : wine and resveratrol intake

    NARCIS (Netherlands)

    Siedlinski, M; Boer, J M A; Smit, H A; Postma, D S; Boezen, H M

    Wine intake is associated with a better lung function in the general population, yet the source of this effect is unknown. Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, its effects being partially mediated via induction of Sirtuin (SIRT) 1 activity. We assessed the

  20. Clinical risk factors as predictors of postmenopausal osteoporosis in general practice

    NARCIS (Netherlands)

    Versluis, RGJA; Papapoulos, SE; de Bock, GH; Zwinderman, AH; Petri, H; van de Ven, CM; Springer, MP

    2001-01-01

    Background. Case-finding strategies to identify women with high risk for osteoporotic fractures have recently been proposed, but little information about such an approach in general practice known. Aim: To study the validity of the proposed case-finding for osteoporosis. Design of study: Survey usin

  1. Dietary factors and lung function in the general population : wine and resveratrol intake

    NARCIS (Netherlands)

    Siedlinski, M; Boer, J M A; Smit, H A; Postma, D S; Boezen, H M

    2012-01-01

    Wine intake is associated with a better lung function in the general population, yet the source of this effect is unknown. Resveratrol, a polyphenol in wine, has anti-inflammatory properties in the lung, its effects being partially mediated via induction of Sirtuin (SIRT) 1 activity. We assessed the

  2. Genetic, psychosocial and clinical factors associated with hippocampal volume in the general population.

    Science.gov (United States)

    Janowitz, D; Schwahn, C; Borchardt, U; Wittfeld, K; Schulz, A; Barnow, S; Biffar, R; Hoffmann, W; Habes, M; Homuth, G; Nauck, M; Hegenscheid, K; Lotze, M; Völzke, H; Freyberger, H J; Debette, S; Grabe, H J

    2014-10-14

    The hippocampus--crucial for memory formation, recall and mood regulation--is involved in the pathophysiology of dementia and depressive disorders. Recent genome-wide association studies (GWAS) have identified five genetic loci associated with hippocampal volume (HV). Previous studies have described psychosocial and clinical factors (for example, smoking, type 2 diabetes and hypertension) to have an impact on HV. However, the interplay between genetic, psychosocial and clinical factors on the HV remains unclear. Still, it is likely that genetic variants and clinical or psychosocial factors jointly act in modifying HV; it might be possible they even interact. Knowledge of these factors might help to quantify ones individual risk of or rather resilience against HV loss. We investigated subjects (N=2463; 55.7% women; mean age 53 years) from the Study of Health in Pomerania (SHIP-2; SHIP-TREND-0) who underwent whole-body magnetic resonance imaging (MRI) and genotyping. HVs were estimated with FreeSurfer. For optimal nonlinear model fitting, we used regression analyses with restricted cubic splines. Genetic variants and associated psychosocial or clinical factors were jointly assessed for potential two-way interactions. We observed associations between HV and gender (Psmoking (P=0.0058), diastolic blood pressure (P=0.0211), rs7294919 (P=0.0065), rs17178006 (P=0.0002), rs6581612 (P=0.0036), rs6741949 (P=0.0112) and rs7852872 (P=0.0451). In addition, we found three significant interactions: between rs7294919 and smoking (P=0.0473), rs7294919 and diastolic blood pressure (P=0.0447) and between rs7852872 and rs6581612 (P=0.0114). We suggest that these factors might have a role in the individual susceptibility to hippocampus-associated disorders.

  3. Contributions from specific and general factors to unique deficits: two cases of mathematics learning difficulties

    Directory of Open Access Journals (Sweden)

    Vitor Geraldi Haase

    2014-02-01

    Full Text Available Mathematics learning difficulties are a highly comorbid and heterogeneous set of disorders linked to several dissociable mechanisms and endophenotypes. Two of these endophenotypes consist of primary deficits in number sense and verbal numerical representations. However, currently acknowledged endophenotypes are underspecified regarding the role of automatic vs. controlled information processing, and their description should be complemented. Two children with specific deficits in number sense and verbal numerical representations and normal or above-normal intelligence and preserved visuospatial cognition illustrate this point. Child H.V. exhibited deficits in number sense and fact retrieval. Child G.A. presented severe deficits in orally presented problems and transcoding tasks. A partial confirmation of the two endophenotypes that relate to the number sense and verbal processing was obtained, but a much more clear differentiation between the deficits presented by H.V. and G.A. can be reached by looking at differential impairments in modes of processing. H.V. is notably competent in the use of controlled processing but has problems with more automatic processes, such as nonsymbolic magnitude processing, speeded counting and fact retrieval. In contrast, G.A. can retrieve facts and process nonsymbolic magnitudes but exhibits severe impairment in recruiting executive functions and the concentration that is necessary to accomplish transcoding tasks and word problem solving. These results indicate that typical endophenotypes might be insufficient to describe accurately the deficits that are observed in children with mathematics learning abilities. However, by incorporating domain-specificity and modes of processing into the assessment of the endophenotypes, individual deficit profiles can be much more accurately described. This process calls for further specification of the endophenotypes in mathematics learning difficulties.

  4. Contributions from specific and general factors to unique deficits: two cases of mathematics learning difficulties.

    Science.gov (United States)

    Haase, Vitor G; Júlio-Costa, Annelise; Lopes-Silva, Júlia B; Starling-Alves, Isabella; Antunes, Andressa M; Pinheiro-Chagas, Pedro; Wood, Guilherme

    2014-01-01

    Mathematics learning difficulties are a highly comorbid and heterogeneous set of disorders linked to several dissociable mechanisms and endophenotypes. Two of these endophenotypes consist of primary deficits in number sense and verbal numerical representations. However, currently acknowledged endophenotypes are underspecified regarding the role of automatic vs. controlled information processing, and their description should be complemented. Two children with specific deficits in number sense and verbal numerical representations and normal or above-normal intelligence and preserved visuospatial cognition illustrate this point. Child H.V. exhibited deficits in number sense and fact retrieval. Child G.A. presented severe deficits in orally presented problems and transcoding tasks. A partial confirmation of the two endophenotypes that relate to the number sense and verbal processing was obtained, but a much more clear differentiation between the deficits presented by H.V. and G.A. can be reached by looking at differential impairments in modes of processing. H.V. is notably competent in the use of controlled processing but has problems with more automatic processes, such as nonsymbolic magnitude processing, speeded counting and fact retrieval. In contrast, G.A. can retrieve facts and process nonsymbolic magnitudes but exhibits severe impairment in recruiting executive functions and the concentration that is necessary to accomplish transcoding tasks and word problem solving. These results indicate that typical endophenotypes might be insufficient to describe accurately the deficits that are observed in children with mathematics learning abilities. However, by incorporating domain-specificity and modes of processing into the assessment of the endophenotypes, individual deficit profiles can be much more accurately described. This process calls for further specification of the endophenotypes in mathematics learning difficulties.

  5. Weak K→π generalized form factors and transverse transition quark-spin density from the instanton vacuum

    Directory of Open Access Journals (Sweden)

    Hyeon-Dong Son

    2015-07-01

    Full Text Available We investigate the generalized K→π transition vector and tensor form factors, from which we derive the transverse quark spin density in the course of the K→π transition, based on the nonlocal chiral quark model from the instanton vacuum. The results of the transition tensor form factor are in good agreement with recent data of lattice QCD. The behavior of the transverse quark spin density of the K→π transition turns out to be very similar to those of the pion and the kaon.

  6. Effect of Daylight on Melatonin and Subjective General Health Factors in Elderly People

    Directory of Open Access Journals (Sweden)

    Zohre KARAMI

    2016-05-01

    Full Text Available Background: This paper investigated the effect of daylight on morning and night melatonin, subjective general health using GHQ questionnaire, sleepiness and alertness on elderly who lived in nursing houses.Methods: Nineteen nursing home residents participated voluntarily. They exposed to daylight from 9 to 10 a.m. and from 4 to 5 p.m. for 6 wk. The level of melatonin in the morning and at night was measured. General health of all participants was evaluated using General Health Questionnaire (GHQ as well.Results: Daylight exposure significantly affected morning melatonin from 25.39 pg/ml to 59.77 pg/ml (P=0.001 and night melatonin were changed from 40.30pg/ml to 34.41pg/ml (P=0.081. Mean score of general health changed 36.31 to 29.89 (P=0.003. Karolinska Sleepiness Scale (KSS and Visual Analogue Scale (VAS showed increase sleepiness and decrease alertness from 3:00 to 7:00 a.m. Sleepiness decreased and alertness increased during 1:00 p.m. and 20:00 p.m.Conclusions: Daylight exposure could delay sleep phase and correction of circadian rhythm in elderly. Anxiety and insomnia could be improved with daylight exposure. It suggests that elders should be exposed to scheduled daylight in morning and evening for prevention and improvement of mental disorders. Adequate light should be provided for elder’s homes and nursing house.  Keywords: Daylight, Melatonin, Health, Circadian rhythm, Elderly, Iran

  7. International factor mobility, informal interest rate and capital market imperfection: a general equilibrium analysis

    OpenAIRE

    Chaudhuri, Sarbajit; GUPTA, Manash Ranjan

    2011-01-01

    This paper makes a pioneering attempt to provide a theory of determination of interest rate in the informal credit market in a small open economy in terms of a three-sector general equilibrium model. There are two informal sectors which obtain production loans from a monopolistic moneylender and employ labour from the informal labour market. On the other hand, the formal sector employs labour at an institutionally fixed wage rate and takes loans from the competitive formal credit market. We s...

  8. A General Factor-Analytic Procedure for Assessing Response Bias in Questionnaire Measures

    Science.gov (United States)

    Ferrando, Pere J.; Lorenzo-Seva, Urbano; Chico, Eliseo

    2009-01-01

    This article proposes procedures for simultaneously assessing and controlling acquiescence and social desirability in questionnaire items. The procedures are based on a semi-restricted factor-analytic tridimensional model, and can be used with binary, graded-response, or more continuous items. We discuss procedures for fitting the model (item…

  9. [Methylmercury exposure in the general population; toxicokinetics; differences by gender, nutritional and genetic factors].

    Science.gov (United States)

    González-Estecha, Montserrat; Bodas-Pinedo, Andrés; Guillén-Pérez, José Jesús; Rubio-Herrera, Miguel Ángel; Ordóñez-Iriarte, José M; Trasobares-Iglesias, Elena M; Martell-Claros, Nieves; Martínez-Álvarez, Jesús Román; Farré-Rovira, Rosaura; Herráiz-Martínez, Miguel Ángel; Martínez-Astorquiza, Txantón; Calvo-Manuel, Elpidio; Sáinz-Martín, María; Bretón-Lesmes, Irene; Prieto-Menchero, Santiago; Llorente-Ballesteros, M Teresa; Martínez-García, M José; Salas-Salvadó, Jordi; Bermejo-Barrera, Pilar; García-Donaire, José Antonio; Cuadrado-Cenzual, M Ángeles; Gallardo-Pino, Carmen; Moreno-Rojas, Rafael; Arroyo-Fernández, Manuel; Calle-Pascual, Alfonso

    2014-11-01

    Mercury is an environmental toxicant that causes numerous adverse effects on human health and natural ecosystems. The factors that determine the existance of adverse effects, as well as their severity are, among others: the chemical form of mercury (elemental, inorganic, organic), dosis, age, period of exposure, pathways of exposure and environmental, nutritional and genetic factors. In the aquatic cycle of mercury, once it has been deposited, it is transformed into methylmercury due to the action of certain sulphate-reducing bacteria, which bioaccumulates in the aquatic organisms and moves into the food chain. The methylmercury content of large, long-lived fish such as swordfish, shark, tuna or marlin, is higher. Methylmercury binds to protein in fish and is therefore not eliminated by cleaning or cooking the fish. Fetuses and small children are more vulnerable to the neurotoxic effects of methylmercury from the consumption of contaminated fish. Methylmercury is absorbed in the gastrointestinal tract and crosses the blood-brain barrier and the placenta. The intake of certain dietary components such as polyunsaturated fatty acids, selenium, fiber, thiol compounds, certain phytochemicals and other nutrients can modify methylmercury bioaccesibility and its toxicity. Apart from environmental factors, genetic factors can influence mercury toxicity and explain part of the individual vulnerability.

  10. Risk factors of bradycardia in 50 cases of gastric surgery under general anesthesia

    Directory of Open Access Journals (Sweden)

    Reza Shariat Moharari

    2014-10-01

    Conclusion: The history of gastric cancer and previous chemotherapy might be the only common factors that cause to bradycardia and irresponsible asystole during gastric surgery in these patients. It seems that only close monitoring and vigilant anesthesiologist require for treatment and prevention from adverse effect of such a sever bradycardia event.

  11. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    Science.gov (United States)

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four composites,…

  12. Pediatric acute respiratory distress syndrome: Host factors in Down syndrome and the general population

    NARCIS (Netherlands)

    M. Bruijn

    2013-01-01

    We find that Down syndrome is an important risk factor for developing acute respiratory distress syndrome (ARDS) in children, but the reason why remains to be elucidated. In addition, we find several differences between adult and pediatric ARDS. The association between C-reactive protein (CRP) level

  13. Risk factors for conversion during laparoscopic cholecystectomy - experiences from a general teaching hospital.

    NARCIS (Netherlands)

    Steeg, H.J.J. van der; Alexander, S.; Houterman, S.; Slooter, G.D.; Roumen, R.M.

    2011-01-01

    BACKGROUND AND AIMS: Laparoscopic cholecystectomy (LC) is the gold standard for treating symptomatic cholelithiasis. Conversion, however, is sometimes necessary. The aim of this study was to determine predictive factors of conversion in patients undergoing LC for various indications in elective and

  14. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    Science.gov (United States)

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four…

  15. Risk factors for conversion during laparoscopic cholecystectomy - experiences from a general teaching hospital.

    NARCIS (Netherlands)

    Steeg, H.J.J. van der; Alexander, S.; Houterman, S.; Slooter, G.D.; Roumen, R.M.

    2011-01-01

    BACKGROUND AND AIMS: Laparoscopic cholecystectomy (LC) is the gold standard for treating symptomatic cholelithiasis. Conversion, however, is sometimes necessary. The aim of this study was to determine predictive factors of conversion in patients undergoing LC for various indications in elective and

  16. Conditions, factors and criteria for successful project implementation: generalization of experience of project management

    Directory of Open Access Journals (Sweden)

    Feraru Galina Sergeevna

    2014-11-01

    Full Text Available The article addresses issues characterizing features of project management contributing to their competitive advantage; shows the factors and criteria of success of projects and the main reasons for their failures, making the failed efforts of developers to create projects.

  17. Personality factors and suicide risk in a representative sample of the German general population.

    Directory of Open Access Journals (Sweden)

    Victor Blüml

    Full Text Available OBJECTIVE: Previous research has shown an association between certain personality characteristics and suicidality. Methodological differences including small sample sizes and missing adjustment for possible confounding factors could explain the varying results. The aim of this study was to assess the impact of the Big Five personality dimensions on suicidality in a representative population based sample of adults. METHOD: Interviews were conducted in a representative German population-based sample (n=2555 in 2011. Personality characteristics were assessed using the Big Five Inventory-10 (BFI-10 and suicide risk was assessed with the Suicidal Behaviors Questionnaire-Revised (SBQ-R. Multivariate logistic regression models were calculated adjusting for depression, anxiety, and various sociodemographic variables. RESULTS: Neuroticism and openness were significantly associated with suicide risk, while extraversion and conscientiousness were found to be protective. Significant sex differences were observed. For males, extraversion and conscientiousness were protective factors. Neuroticism and openness were found to be associated with suicide risk only in females. These associations remained significant after adjusting for covariates. CONCLUSION: The results highlight the role of personality dimensions as risk factors for suicide-related behaviors. Different personality dimensions are significantly associated with suicide-related behaviors even when adjusting for other known risk factors of suicidality.

  18. Basic Factors that Affect General Academic Motivation Levels of Candidate Preschool Teachers

    Science.gov (United States)

    Celikoz, Nadir

    2010-01-01

    The purpose of this study is to investigate some personal and familial factors that affect overall academic motivation levels of candidate preschool teachers. The study group of this research consists of 285 students attending the child development and preschool education department at Selcuk University Faculty of Vocational Education in the…

  19. Lifestyle factors and contact to general practice with respiratory alarm symptoms-a population-based study

    DEFF Research Database (Denmark)

    Sele, Lisa Maria Falk; Elnegaard, Sandra; Balasubramaniam, Kirubakaran;

    2016-01-01

    BACKGROUND: A prerequisite for early lung cancer diagnosis is that individuals with respiratory alarm symptoms (RAS) contact a general practitioner (GP). This study aims to determine the proportion of individuals in the general population who contact a GP with RAS and to analyse the association...... between lifestyle factors and contact to GPs with RAS. METHODS: A web-based survey of 100 000 individuals randomly selected from the Danish Civil Registration System. Items regarding experience of RAS (prolonged coughing, shortness of breath, coughing up blood, and prolonged hoarseness), GP contacts......, and lifestyle factors (smoking status, alcohol intake, and body mass index) were included. RESULTS: In total 49 706 (52.5 %) individuals answered the questionnaire. Overall 7870 reported at least one respiratory alarm symptom, and of those 39.6 % (3 080) had contacted a GP. Regarding specific symptoms...

  20. Using a factor mixture modeling approach in alcohol dependence in a general population sample.

    Science.gov (United States)

    Kuo, Po-Hsiu; Aggen, Steven H; Prescott, Carol A; Kendler, Kenneth S; Neale, Michael C

    2008-11-01

    Alcohol dependence (AD) is a complex and heterogeneous disorder. The identification of more homogeneous subgroups of individuals with drinking problems and the refinement of the diagnostic criteria are inter-related research goals. They have the potential to improve our knowledge of etiology and treatment effects, and to assist in the identification of risk factors or specific genetic factors. Mixture modeling has advantages over traditional modeling that focuses on either the dimensional or categorical latent structure. The mixture modeling combines both latent class and latent trait models, but has not been widely applied in substance use research. The goal of the present study is to assess whether the AD criteria in the population could be better characterized by a continuous dimension, a few discrete subgroups, or a combination of the two. More than seven thousand participants were recruited from the population-based Virginia Twin Registry, and were interviewed to obtain DSM-IV (Diagnostic and Statistical Manual of Mental Disorder, version IV) symptoms and diagnosis of AD. We applied factor analysis, latent class analysis, and factor mixture models for symptom items based on the DSM-IV criteria. Our results showed that a mixture model with 1 factor and 3 classes for both genders fit well. The 3 classes were a non-problem drinking group and severe and moderate drinking problem groups. By contrast, models constrained to conform to DSM-IV diagnostic criteria were rejected by model fitting indices providing empirical evidence for heterogeneity in the AD diagnosis. Classification analysis showed different characteristics across subgroups, including alcohol-caused behavioral problems, comorbid disorders, age at onset for alcohol-related milestones, and personality. Clinically, the expanded classification of AD may aid in identifying suitable treatments, interventions and additional sources of comorbidity based on these more homogenous subgroups of alcohol use

  1. The World of Virtual Exhibitions

    Directory of Open Access Journals (Sweden)

    Irena Eiselt

    2013-09-01

    Full Text Available EXTENDED ABSTRACTSpecial collections of the National and University Library (NUK hide a lot of items of precious value. The Slovenian cultural heritage is stored on paper or on other media as a part of the library’s Manuscripts, Incunabula and Rare Books Collection, Old Prints Collection, Maps and Pictorial Collection, Music Collection, Ephemera Collection, Serials Collection, and Slovenian Diaspora Publications Collection. Only a small part of the treasures is temporary revealed to the public on special exhibitions. The idea of virtual exhibitions of library treasures was born in 2005. The library aimed to exhibit precious items of special collections of high historical or artistic value. In 2008 the first two virtual exhibitions were created in-house offering access to the rich collections of old postcards of Ljubljana at the beginning of 20th century kept in the Maps and Pictorial Collection of NUK. They were soon followed by other virtual exhibitions. At the beginning they were organised in the same way as physical exhibitions, afterwards different programs were used for creation of special effects (for ex. 3D wall. About two years ago it was decided that the creation of virtual exhibitions will be simplified. Files of digitised and borndigital library materials in jpg format are imported to MS PowerPoint 2010. Each jpg file is now formatted by adding a frame, a description … to the slides which are saved as jpg files. The last step is the import of jpg files into Cooliris application used for NUK web exhibitions. In the paper the virtual exhibition design and creation, the technical point of view and criteria for the selection of exhibition content are explained following the example of the virtual exhibitions the Old Postcards of Ljubljana, Photo Ateliers in Slovenia, a collection of photographs Four Seasons by Fran Krašovec and photos of Post-Earthquake Ljubljana in 1895.

  2. General practitioners’ use of absolute risk versus individual risk factors in cardiovascular disease prevention: an experimental study

    OpenAIRE

    Jansen, Jesse; Bonner, Carissa; McKinn, Shannon; Irwig, Les; Glasziou, Paul ,; Doust, Jenny; Teixeira-Pinto, Armando; Hayen, Andrew; Turner, Robin; McCaffery, Kirsten

    2014-01-01

    Objective To understand general practitioners’ (GPs) use of individual risk factors (blood pressure and cholesterol levels) versus absolute risk in cardiovascular disease (CVD) risk management decision-making. Design Randomised experiment. Absolute risk, systolic blood pressure (SBP), cholesterol ratio (total cholesterol/high-density lipoprotein (TC/HDL)) and age were systematically varied in hypothetical cases. High absolute risk was defined as 5-year risk of a cardiovascular event >15%, hig...

  3. STUDY OF PREMATURE BABIES IN RELATION TO ITS OUTCOME AND ANTENATAL RISK FACTORS AT GENERAL HOSPITAL SANGLI

    OpenAIRE

    Satish D; Suresh K; Renuka S

    2014-01-01

    : OBJECTIVE: To know the neonatal outcome and antenatal risk factors among premature babies. MATERIAL & METHODS: STUDY DESIGN: A retrospective study. SETTING: Neonatal Intensive Care Unit (NICU) of General Hospital Sangli under Government Medical College, Miraj. SAMPLE SIZE: 134 Premature babies admitted during the year 2013 in NICU. DATA COLLECTION: From the case sheet of the study subjects, with the help of pre structured proforma. STUDY PERIOD: January 2013 to December ...

  4. Risk factors and trends in attempting or committing suicide in Dutch general practice in 1983–2009 and tools for early recognition.

    NARCIS (Netherlands)

    Donker, G.A.; Wolters, I.; Schellevis, F.

    2010-01-01

    Background: Many patients visit their general practitioner (GP) before attempting or committing suicide. This study analyses determinants and trends of suicidal behaviour to enhance early recognition of risk factors in general practice. Method: Analysis of trends, patient and treatment

  5. The Willingness-to-Pay for General Practitioners in Contractual Service and Influencing Factors among Empty Nesters in Chongqing, China

    Directory of Open Access Journals (Sweden)

    Fei Chen

    2015-08-01

    Full Text Available Background: In 2012, a pilot health policy of contractual service relations between general practitioners and patients was implemented in China. Due to the decline in body and cognitive function, as well as the lack of family care and narrow social support networks, the demand of health services among the elderly is much higher than that among the general population. This study aims to probe into the empty nesters’ willingness-to-pay for general practitioners using a contractual service policy, investigating empty nesters’ payment levels for the service, and analyze the main factors affecting the willingness of empty-nesters’ general practitioners using contractual service supply cost. Methods: This cross-sectional study adopted a multistage stratified sampling method to survey 865, city empty nesters (six communities in three districts of one city aged 60–85 years. A condition value method was used to infer the distribution of the willingness-to-pay; Cox’s proportional hazards regression model was used to analyze the influencing factors of willingness-to-pay. Results: More than seventy percent (76.6% of the empty nesters in this city were willing to pay general practitioners using contract service in Chongqing. The level of willingness-to-pay for the surveyed empty nesters was 34.1 yuan per year. The median value was 22.1 yuan per year, which was below the Chongqing urban and rural cooperative medical insurance individual funding level (60 yuan per year in 2013. Cox’s proportional hazards regression model analysis showed that the higher the education level was, the worse the self-reported health status would be, accompanied by higher family per capita income, higher satisfaction of community health service, and higher willingness-to-pay empty nesters using a contract service. Women had a higher willingness-to-pay than men. Conclusions: The willingness-to-pay for general practitioners by contractual service is high among city empty

  6. Changing the general factor of personality and the c-fos gene expression with methylphenidate and self-regulation therapy.

    Science.gov (United States)

    Micó, Joan C; Amigó, Salvador; Caselles, Antonio

    2012-07-01

    A deepening in the biological nature of the general factor of personality (GFP) is suggested: the activation level of the stress system is here represented by the gene expression of c-fos. The results of a single case experimental design are reported. A model of four coupled differential equations that explains the human personality dynamics as a consequence of a single stimulant drug intake has been fitted to psychological and biological experimental data. The stimulant-drug conditioning and its adaptation to the considered mathematical model is also studied for both kinds of measures. The dynamics of the c-fos expression presents a similar pattern to the dynamics of the psychological measures of personality assessed by the GFP-FAS (Five-Adjective Scale of the General Factor of Personality) as a consequence of a single dose of stimulant drug (methylphenidate). The model predicts similar dynamic patterns for both psychological and biological measures. This study proves that describing mathematically the dynamics of the effects of a stimulant drug as well as the effects of a conditioning method on psychological or subjective variables and on gene expression is possible. It verifies the existence of biological mechanisms underlying the dynamics of the General Factor of Personality (GFP).

  7. Mammographic Texture Resemblance generalizes as an independent risk factor of breast cancer

    DEFF Research Database (Denmark)

    Chernoff, Konstantin; Christopher, S G; Karemore, Gopal

    as an independent risk factor in an unrelated cohort. METHOD AND MATERIALS The statistics of texture were recorded in digitalized film-mammograms of one 4-year prospective study (S1, Dutch screening program) of 245 breast cancers and 250 matched controls. From an independent cohort study (S2, Mayo Mammography...... Health Study cohort) 226 incident breast cancer cases diagnosed through 2008 and 442 matched controls (on age) were used for scoring screening digitized mammograms that were ascertained years prior to diagnosis 1993-2006. Mammographic percent density (PD), using Cumulus, and other major risk factors were...... ascertained in S2. Finally S2 was MTR scored based on textures from S1 and S2 in a leave-two-out fashion. Scores on S2 were related to future breast cancer incidence by AUC and analyses of quartiles adjusted for BMI, menopause status, and postmenopausal hormone (PMH) use. A combined density and MTR model...

  8. [Malignant mesothelioma risk factors: experience in the General Hospital of Mexico].

    Science.gov (United States)

    Hernández-Solís, Alejandro; Garcia-Hernández, Cyntia; Reding-Bernal, Arturo; Cruz-Ortiz, Humberto; Cicero-Sabido, Raúl

    2013-01-01

    Antecedentes: el mesotelioma maligno es un tumor de mal pronóstico relacionado con el contacto con asbesto; sin embargo, existen numerosos casos sin este antecedente. Objetivo: describir la relación entre la exposición al asbesto y otros factores con el mesotelioma maligno. Material y métodos: estudio retrospectivo de casos y controles pareado 1: 1-3 por edad y sexo de pacientes con diagnóstico de mesotelioma maligno. Se registraron: la exposición al asbesto, tabaco, humo de leña y antecedentes familiares de cáncer. Se empleó regresión logística para razones de momios (ORs). Resultados: se estudiaron 61 casos con mesotelioma maligno, 41 hombres y 20 mujeres. La edad promedio fue 56 ± 13 años; 56 casos fueron mesotelioma maligno epitelial (91.8%), tres sarcomatosos (4.9%), uno desmoplásico y uno bifásico. Sólo en 8 (13.1%) se identificó exposición al asbesto. En el modelo de regresión logística el asbesto tuvo una razón de momios de 3.083 p > 0.05. Ninguna otra variable resultó ser un factor de riesgo para mesotelioma maligno. Conclusiones: la exposición al asbesto es un factor de riesgo para mesotelioma maligno, lo que se confirma en este estudio; sin embargo, es importante ampliar la investigación de otros posibles factores causales de esta enfermedad.

  9. [General pharmacological studies on human natural tumor necrosis factor (MHR-24)].

    Science.gov (United States)

    Sato, M; Imada, K; Iida, S; Ohashi, K; Kimura, S; Niho, T

    1993-04-01

    The general pharmacological properties of MHR-24 were studied in various experimental animals. Intravenously (i.v.)-administered MHR-24 at 8.6 x 10(2) JRU/kg or more produced fever in rabbits. MHR-24 at 3 x 10(4) JRU/kg or more caused tachycardia; and at 1 x 10(5) JRU/kg or more, it lowered arterial blood pressure in anesthetized monkeys. In rats, MHR-24 at 2.9 x 10(4) JRU/kg or more showed a diuretic action and inhibitory effects on gastric juice secretion and carrageenin-induced paw edema. Furthermore, MHR-24 at a large dose (8.6 x 10(4) or 2.9 x 10(5) JRU/kg, i.v.) decreased spontaneous locomotor activity, had an inhibitory effect on acetic acid-induced writhing and potentiated intestinal propulsion in mice; and it caused the appearance of rest wave on acute spontaneous electroencephalograms in rabbits. Pretreatment of the animals with the cyclooxygenase inhibitor indomethacin abolished the fever and potentiation of intestinal propulsion caused by MHR-24. Therefore, these data seem to indicate that some of the effects of MHR-24 are mediated via cyclooxygenase pathways. The results suggested that, except for the above results, MHR-24 has no noticeable effects on the central nervous, autonomic nervous, respiratory and cardiovascular systems and others in general pharmacological studies.

  10. Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte–macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity

    Science.gov (United States)

    Jurickova, I; Collins, M H; Chalk, C; Seese, A; Bezold, R; Lake, K; Allmen, D; Frischer, J S; Falcone, R A; Trapnell, B C; Denson, L A

    2013-01-01

    Granulocyte–macrophage colony-stimulating factor (GM-CSF) autoantibodies are associated with stricturing behaviour in Crohn disease (CD). We hypothesized that CD ileal lamina propria mononuclear cells (LPMC) would produce GM-CSF autoantibodies and peripheral blood (PB) samples would contain GM-CSF neutralizing capacity (NC). Paediatric CD and control PBMC and ileal biopsies or LPMC were isolated and cultured and GM-CSF, immunoglobulin (Ig)G and GM-CSF autoantibodies production were measured by enzyme-linked immunosorbent assay (ELISA). Basal and GM-CSF-primed neutrophil bacterial killing and signal transducer and activator of transcription 5 (STAT5) tyrosine phosphorylation (pSTAT5) were measured by flow cytometry. GM-CSF autoantibodies were enriched within total IgG for LPMC isolated from CD ileal strictures and proximal margins compared to control ileum. Neutrophil bacterial killing was reduced in CD patients compared to controls. Within CD, neutrophil GM-CSF-dependent STAT5 activation and bacterial killing were reduced as GM-CSF autoantibodies increased. GM-CSF stimulation of pSTAT5 did not vary between controls and CD patients in washed PB granulocytes in which serum was removed. However, GM-CSF stimulation of pSTAT5 was reduced in whole PB samples from CD patients. These data were used to calculate the GM-CSF NC. CD patients with GM-CSF NC greater than 25% exhibited a fourfold higher rate of stricturing behaviour and surgery. The likelihood ratio (95% confidence interval) for stricturing behaviour for patients with elevation in both GM-CSF autoantibodies and GM-CSF NC was equal to 5 (2, 11). GM-CSF autoantibodies are produced by LPMC isolated from CD ileal resection specimens and are associated with reduced neutrophil bacterial killing. CD peripheral blood contains GM-CSF NC, which is associated with increased rates of stricturing behaviour. PMID:23600834

  11. Hepatitis B virus infections and risk factors among the general population in Anhui Province, China: an epidemiological study

    Directory of Open Access Journals (Sweden)

    Li Xiaoqing

    2012-04-01

    Full Text Available Abstract Background Hepatitis B is one of the most common infectious diseases in China. The aim of this study was to determine the prevalence of hepatitis B surface antigen (HBsAg among the general population and the risk factors associated with HBV infection in Anhui province, China. Methods A provincial serosurvey was conducted in four cities, and selected through stratified clustering sampling. Data on demographics, immunization history, medical history, family medical history, and life history were collected, along with serum tested for HBsAg. Completed surveys were analysed from 8,875 participants. Results Overall prevalence of HBsAg was 7.44%. Using multivariate analysis, older age was a risk factor for HBsAg infection among children younger than 15 years. Among adults 15-59 years old, the risk factors were male gender, a history of surgical operations, at least one HBsAg-positive family member, and non-vaccination. For adults older than 59 years, the risk factor was a blood transfusion history. Conclusions Though Anhui province has already reached the national goal of reducing HBsAg prevalence to less than 1% among children younger than 5 years, there are still several risk factors for HBsAg infection among the older population. Immunization programs should continue to focus on adults, and interventions should be taken to reduce risk factors associated with being infected with Hepatitis B.

  12. 轨迹数据的多因素概化%Multi-factor generalization of trajectory data

    Institute of Scientific and Technical Information of China (English)

    张磊; 杨光; 王志超

    2012-01-01

    针对轨迹数据概化大多只考虑空间位置因素,而忽略了其他轨迹特性,从而造成概化前后信息丢失过大的问题,提出轨迹数据的多因素概化方法.该方法综合考虑了空间位置、时间、速度、加速度和方向角等因素,首先,通过在轨迹点聚类的距离约束中加入多因素对DBSCAN算法进行改进.然后,用类簇的代表点进行区域划分,连接轨迹经过的区域生成概化轨迹.由于多因素下的轨迹概化缺少统一的衡量标准,从信息丢失和概化前后效果比较2个方面,提出多因素下轨迹概化效果的度量方法.飓风数据实验表明,所提方法生成的概化轨迹信息丢失明显减少,聚类结果更加接近原始轨迹.%In order to solve the problem that most of current trajectory data generalization methods only consider the spatial characteristic and ignore other trajectory features, thus resulting in information loss, a method of multiple-factor generalization of trajectory data (TRMGEN) is proposed, which considers trajectory features, such as spatial location, time, velocity, direction angle and acceleration, etc. First, the DBSCAN algorithm is improved by adding factors into distance constraint when clustering the points. Then, the representative points of clusters are used in the region division, and the regions are connected to generate the generalized trajectory. As the trajectory multi-factor generalization lacks unified measure standard, from the aspects of information loss and the similarity with original trajectory, a method for measuring generalization effect is presented. Experimental results on the Hurricane dataset show that the TRMGEN can greatly reduce the information loss of the generalized trajectory, and the cluster result of the generalized trajectory is closer to the original trajectory.

  13. Mesotelioma maligno: factores de riesgo, experiencia en el Hospital General de México

    OpenAIRE

    Alejandro Hernández-Solís; Cyntia Garcia-Hernández; Arturo Reding-Bernal; Humberto Cruz-Ortiz; Raúl Cicero-Sabido

    2013-01-01

    Antecedentes: el mesotelioma maligno es un tumor de mal pronóstico relacionado con el contacto con asbesto; sin embargo, existen numerosos casos sin este antecedente. Objetivo: describir la relación entre la exposición al asbesto y otros factores con el mesotelioma maligno. Material y métodos: estudio retrospectivo de casos y controles pareado 1: 1-3 por edad y sexo de pacientes con diagnóstico de mesotelioma maligno. Se registraron: la exposición al asbesto, tabaco, humo de leña y antecedent...

  14. Factors influencing general practitioner referral of patients developing end-stage renal failure: a standardised case-analysis study.

    LENUS (Irish Health Repository)

    Montgomery, Anthony J

    2006-01-01

    BACKGROUND: To understand why treatment referral rates for ESRF are lower in Ireland than in other European countries, an investigation of factors influencing general practitioner referral of patients developing ESRF was conducted. METHOD: Randomly selected general practitioners (N = 51) were interviewed using 32 standardised written patient scenarios to elicit referral strategies. Main outcome measures: General practitioner referral levels and thresholds for patients developing end-stage renal disease; referral routes (nephrologist vs other physicians); influence of patient age, marital status and co-morbidity on referral. RESULTS: Referral levels varied widely with the full range of cases (0-32; median = 15) referred by different doctors after consideration of first laboratory results. Less than half (44%) of cases were referred to a nephrologist. Patient age (40 vs 70 years), marital status, co-morbidity (none vs rheumatoid arthritis) and general practitioner prior specialist renal training (yes or no) did not influence referral rates. Many patients were not referred to a specialist at creatinine levels of 129 micromol\\/l (47% not referred) or 250 micromol\\/l (45%). While all patients were referred at higher levels (350 and 480 micromol\\/l), referral to a nephrologist decreased in likelihood as scenarios became more complex; 28% at 129 micromol\\/l creatinine; 28% at 250 micromol\\/l; 18% at 350 micromol\\/l and 14% at 480 micromol\\/l. Referral levels and routes were not influenced by general practitioner age, sex or practice location. Most general practitioners had little current contact with chronic renal patients (mean number in practice = 0.7, s.d. = 1.3). CONCLUSION: The very divergent management patterns identified highlight the need for guidance to general practitioners on appropriate management of this serious condition.

  15. Factors influencing general practitioner referral of patients developing end-stage renal failure: a standardised case-analysis study

    Directory of Open Access Journals (Sweden)

    Shannon William

    2006-09-01

    Full Text Available Abstract Background To understand why treatment referral rates for ESRF are lower in Ireland than in other European countries, an investigation of factors influencing general practitioner referral of patients developing ESRF was conducted. Method Randomly selected general practitioners (N = 51 were interviewed using 32 standardised written patient scenarios to elicit referral strategies. Main outcome measures: General practitioner referral levels and thresholds for patients developing end-stage renal disease; referral routes (nephrologist vs other physicians; influence of patient age, marital status and co-morbidity on referral. Results Referral levels varied widely with the full range of cases (0–32; median = 15 referred by different doctors after consideration of first laboratory results. Less than half (44% of cases were referred to a nephrologist. Patient age (40 vs 70 years, marital status, co-morbidity (none vs rheumatoid arthritis and general practitioner prior specialist renal training (yes or no did not influence referral rates. Many patients were not referred to a specialist at creatinine levels of 129 μmol/l (47% not referred or 250 μmol/l (45%. While all patients were referred at higher levels (350 and 480 μmol/l, referral to a nephrologist decreased in likelihood as scenarios became more complex; 28% at 129 μmol/l creatinine; 28% at 250 μmol/l; 18% at 350 μmol/l and 14% at 480 μmol/l. Referral levels and routes were not influenced by general practitioner age, sex or practice location. Most general practitioners had little current contact with chronic renal patients (mean number in practice = 0.7, s.d. = 1.3. Conclusion The very divergent management patterns identified highlight the need for guidance to general practitioners on appropriate management of this serious condition.

  16. A comparative overview of general risk factors associated with the incidence of colorectal cancer.

    Science.gov (United States)

    Rasool, Sabha; Kadla, Showkat Ahmad; Rasool, Vamiq; Ganai, Bashir Ahmad

    2013-10-01

    Cancers found in colorectal region remain largely localized to the large intestine and rectum. They are derived from the epithelium and are considered to be among the most frequently detected cancers. They are known to occur in approximately 5 % population of the Western world. After metastasis, a patient's 5-year postsurgical survival chances unfortunately fall from 90 to 10 % or even less. Adenocarcinoma, the most common cell type of colon cancer, alone constitutes 95 % of the cases. Lymphoma and squamous cell carcinoma can also be found in some cases. Because 5 % of persons are predisposed to development of colorectal cancer, this disease has often been addressed as an important public health issue. Factors that are known in particular to increase a person's risk to develop this cancer are as follows: an individual's age, dietary habits, any complaint of obesity, diabetes, previous history of cancer or intestinal polyps, personal habit of alcohol consumption and smoking, family history of colon cancer, race, sex, and ethnicity. Since the risk of colorectal cancer is increasing steadily in Kashmir, India, like in some other corners of Asia, exhaustive efforts are being made to find the association of above given and other risk factors with the development of this gastrointestinal tract cancer. Adoption of Western life style, diet mimicry, together with a habit of having physically inactive life style and consumption of red meat in particular can be blamed as being active players to a considerable extent.

  17. The general environment fit scale: a factor analysis and test of convergent construct validity.

    Science.gov (United States)

    Beasley, Christopher R; Jason, Leonard A; Miller, Steven A

    2012-09-01

    Person-environment fit (P-E fit) was initially espoused as an important construct in the field of community psychology; however, most of the theoretical and empirical development of the construct has been conducted by the industrial/organizational (I/O) psychologists and business management fields. In the current study, the GEFS-a P-E fit measure that was developed from organizational perspectives on fit-was administered to 246 attendees of an annual convention for residents and alumni of Oxford House, a network of over 1,400 mutual-help addiction recovery homes. The authors conducted confirmatory factor and convergent construct validity analyses with the GEFS. The results suggested that the theoretical factor structure of the measure adequately fit the data and provided limited support for the measure's validity. Sufficient supply of resident needs by the Oxford House and similarity between residents and their housemates predicted satisfaction with the recovery home, but only perceived similarity to housemates predicted how long residents intended to stay in the Oxford Houses.

  18. Risk factors of stroke patients admitted to a general hospital in Kuwait.

    Science.gov (United States)

    Ashkanani, Abdulaziz; Hassan, Khalid Ali; Lamdhade, Shekhar

    2013-02-01

    There are limited data on stroke incidence in the Middle East, and only one study from Kuwait. The aim of this study was to establish a baseline status of stroke in Kuwait. We performed a retrospective chart review of all patients admitted from January 1st to December 31st, 2008 to the Amiri Hospital, Kuwait, who either were discharged or passed away with a diagnosis of stroke. Documented risk factors for stroke were analyzed for the total cohort and for male and female subgroups. Stroke subtypes were defined in accordance with the Trial of Org 10172 in acute stroke treatment (TOAST) criteria. There were 151 cases of stroke, of which 90.1% were ischemic. Eighty-five (56.3%) of the patients had diabetes mellitus, 86 (57.0%) had hyperlipidemia, and 104 (68.9%) had hypertension. Statins were used by 42.4% of the 86 hyperlipidemic patients prior to their presentation, and only 66 hypertensive patients (63.5%) were receiving treatment for hypertension prior to their presentation. Atrial fibrillation was diagnosed in 4% of the patients prior to their presentation, and 4% more were diagnosed afterward. History of ischemic heart disease was present in 28.5% of the subjects. This study shows similar rates of risk factors to regionally published reports and provides an updated picture of stroke in Kuwait.

  19. Factors influencing residency choice of general surgery applicants--how important is the availability of a skills curriculum?

    Science.gov (United States)

    Stefanidis, Dimitrios; Miles, William S; Greene, Frederick L

    2009-01-01

    The objective of this study was to assess the factors that impact residency choice by general surgery applicants and the importance of the availability of skill curricula. Fourth-year medical students (n = 104) interviewing for a general surgery position in an academic medical center voluntarily completed an anonymous survey detailing questions about the factors that influenced their choice of a residency program. Applicants were asked to rank in order of importance 14 factors potentially influencing their decision making and to address specifically the value of skills training. Data are reported as medians (range). The applicants' median age was 26 (range, 24-35) years; 44% were women, and the prior simulator exposure was 1 (range, 0-90) hour. The factors influencing the choice of residency in order of importance were the quality of life of current residents, the volume and variety of cases, and the quality of the curriculum (medians, 3-4), followed by the reputation of the institution and the program director, the location, and mentor advice (medians, 6-8); and the presence of expertise in areas of interest, the availability of a skills curriculum, the academic versus private designation, the efficiency of the hospital, and the size of residency (medians, 9-10). Women were more likely than men to rank lifestyle higher. Applicants' decision making was influenced positively in 92% by the presence of an organized skills curriculum. The main determinants of the applicants' choice of a general surgery program are the quality of life of the residents and the anticipated clinical experience and curriculum quality. The availability of organized skills curricula is low in the applicant priorities, but it does influence their decision-making process. These findings may help program directors to optimize their residency curriculum and interviewing process.

  20. GENERAL: Bistability in Coupled Oscillators Exhibiting Synchronized Dynamics

    Science.gov (United States)

    Olusola, O. I.; Vincent, U. E.; Njah, A. N.; Olowofela, J. A.

    2010-05-01

    We report some new results associated with the synchronization behavior of two coupled double-well Duffing oscillators (DDOs). Some sufficient algebraic criteria for global chaos synchronization of the drive and response DDOs via linear state error feedback control are obtained by means of Lyapunov stability theory. The synchronization is achieved through a bistable state in which a periodic attractor co-exists with a chaotic attractor. Using the linear perturbation analysis, the prevalence of attractors in parameter space and the associated bifurcations are examined. Subcritical and supercritical Hopf bifurcations and abundance of Arnold tongues — a signature of mode locking phenomenon are found.

  1. Auto Technology Exhibition in Tianjing

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ The 4th International Automotive Technology Exhibition Tianjing2009,jointly hosted by the Society of Automotive Engineers of China(SAE-China),China Automotive Technology and Research Center(CATRC)and Tianjin Economic-Technological Development Area(TETD),is to be held in Tianjin Binhai International Convention and Exhibition Center from August 27 to August 30 this year.In line with China's national 11th Five-year Plan,The Automobile Industry Revitalization and Adjustments Planning and The Equipment Manufacturing Revitalization and Adjustments Planning,this Exhibition,centered on the theme of automobile and equipment manufacturing,arranges the exhibition halls respectively for private autos,commercial autos and equipment manufacturing etc.

  2. Photowalk Exhibition opens at Microcosm

    CERN Document Server

    Katarina Anthony

    2011-01-01

    The winning photographs from the 2010 Global Particle Physics Photowalk competition will go on display at Microcosm from 11 February to 2 April. The exhibition is part of a global photography event taking place over three continents, with Photowalk exhibitions opening simultaneously at Fermilab in the US, KEK in Japan and here at CERN.   DESY wire chamber - First place people's choice; second place global jury competition. Photographer: Hans-Peter Hildebrandt  If you were one of the 1,300 photography lovers who voted in last year’s Photowalk competition, this exhibition is your chance to see the winning entries in print. The exhibition will take place in the downstairs gallery of Microcosm, overlooking the garden. 15 photographs will be on display, with each of the laboratories that participated in Photowalk represented by their 3 winning entries. Among them will be the “people’s choice” sunburst photo of a particle detector at DESY (Photo 1), and...

  3. GENERAL CONSDIERATIONS ON PRIMARY FACTORS, COMPONENTS AND STAGES OF DECISION MAKING IN ROMANIAN HIGHER EDUCATION

    Directory of Open Access Journals (Sweden)

    Popovici V.E. Virgil - Ion

    2012-12-01

    Full Text Available In the current European context, it is necessary for all universities to become more powerful, and for that, they need full autonomy and decentralization, a very good funding and a total transparency in the decision making. In Romania, one of the consequences of adopting the new Law no.1/2011 - National Education Act, as amended and supplemented, was that all higher education institutions were to reformulate their entire organization and operation strategy and therefore, to redesign the decision-making system. Improving the university management, the decision making in Romanian higher education is challenging in terms of implementation of the Bologna Process principles. All this must be done taking into account automatically, all factors which influence university management, mainly but also the decision-taking process in universities in Romania, assuming that management means taking of decisions. Improving university management, the entire current and future management is linked in some way to the adoption and implementation of decisions.

  4. Cytological factors and their predictive role in comparative radiosensitivity: a general summary

    Energy Technology Data Exchange (ETDEWEB)

    Underbrink, A.G.; Pond, V.

    1976-12-01

    Various cytological factors, including interphase chromosome volume (ICV), nuclear volume (NV), cell volume, DNA content per nucleus and per chromosome, have been reviewed to determine their usefulness as indices to predict radiosensitivity. Topics discussed are: a historical development of the concept of using karyotypic features to estimate radiosensitivity; interrelationships between cellular parameters; relationship of the karyotype to the duration of mitosis and meiosis; correlations between radiobiological end points and cellular parameters after whole-body irradiation in amphibians, insects and mammals; correlations between radiosensitivity and cellular parameters in diverse single-cell organisms; correlations between radiobiological end points and cellular parameters in higher plants irradiated with neutrons and the value of cell parameters to estimate relative biological effectiveness (RBE); and energy absorption and trends in radiosensitivity among species and radiobiological end points. It is concluded that ICV is usually the most useful parameter for predicting radiosensitivity.

  5. Factores asociados a mortalidad perinatal en el hospital general de Chiapas, México

    Directory of Open Access Journals (Sweden)

    Leonor Rivera

    2003-12-01

    Full Text Available OBJETIVO: El objetivo del estudio es identificar factores socioeconómicos, gineco-obstétricos y del producto asociados a mortalidad perinatal. MÉTODOS: Se realizó un estudio de casos y controles pareado. Se consideró caso a los nacidos vivos o muertos que nacieron y fallecieron entre las 28 semanas de gestación a los 7 días de vida extrauterina. y control al producto nacido vivo entre las 28 semanas de gestación y los 7 días de vida extrauterina. Los datos se obtuvieron de los expedientes clínicos hospitalarios. Se estudiaron 99 casos y 197 controles. Se hizo un análisis estadístico utilizando Stata 6.0. RESULTADOS La media de edad de la madre fue de 24.82 años y del producto de 37.78 semanas de gestación. El promedio de peso del producto fue de 2,760 gramos. Los factores asociados a mortalidad perinatal fueron: ocupación del padre agricultor (RM ajustada 3,31; IC 95% 1,26-8,66; índice de riesgo obstétrico alto (RM ajustada 10,57; IC 95% 2,82-39,66, antecedente de cesárea (RM ajustada 2,75; IC 95% 1,37-5,51; cinco y más consultas prenatales (RM ajustada 4,43; IC 95% 1.86-10,54; producto pretérmino (RM ajustada 9,20; IC 95% 4,39-19,25. CONCLUSIONES: Los resultados muestran que es necesario implementar medidas de prevención y control que aseguren la identificación del riesgo en las mujeres embarazadas, con el fin de abatir la incidencia de mortalidad perinatal.

  6. Factores asociados a mortalidad perinatal en el hospital general de Chiapas, México

    Directory of Open Access Journals (Sweden)

    Rivera Leonor

    2003-01-01

    Full Text Available OBJETIVO: El objetivo del estudio es identificar factores socioeconómicos, gineco-obstétricos y del producto asociados a mortalidad perinatal. MÉTODOS: Se realizó un estudio de casos y controles pareado. Se consideró caso a los nacidos vivos o muertos que nacieron y fallecieron entre las 28 semanas de gestación a los 7 días de vida extrauterina. y control al producto nacido vivo entre las 28 semanas de gestación y los 7 días de vida extrauterina. Los datos se obtuvieron de los expedientes clínicos hospitalarios. Se estudiaron 99 casos y 197 controles. Se hizo un análisis estadístico utilizando Stata 6.0. RESULTADOS La media de edad de la madre fue de 24.82 años y del producto de 37.78 semanas de gestación. El promedio de peso del producto fue de 2,760 gramos. Los factores asociados a mortalidad perinatal fueron: ocupación del padre agricultor (RM ajustada 3,31; IC 95% 1,26-8,66; índice de riesgo obstétrico alto (RM ajustada 10,57; IC 95% 2,82-39,66, antecedente de cesárea (RM ajustada 2,75; IC 95% 1,37-5,51; cinco y más consultas prenatales (RM ajustada 4,43; IC 95% 1.86-10,54; producto pretérmino (RM ajustada 9,20; IC 95% 4,39-19,25. CONCLUSIONES: Los resultados muestran que es necesario implementar medidas de prevención y control que aseguren la identificación del riesgo en las mujeres embarazadas, con el fin de abatir la incidencia de mortalidad perinatal.

  7. Globe exhibit wins international acclaim

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    The Globe’s “Universe of Particles” exhibition has recently received four prestigious awards for its avant-garde design. This external praise is great encouragement for the CERN exhibitions currently on the drawing board.   The Universe of Particles exhibition has won 4 awards for its avant-garde design. Back in 2008, the design company Atelier Brückner was presented with a challenge: to design the layout of a new permanent exhibition for CERN, one that would epitomize both the Organization and its research. The brief was concise but complex: the exhibit had to be symbolic of the Organization, use modern technology, engage and immerse visitors, and, preferably, use touch-screen technology. With the help of IArt, an interactive technology firm, and based on the content provided by CERN’s Education Group, Atelier Brückner developed the “Universe of Particles” exhibit as it is today. Its principal concept centred on the s...

  8. Greenhouse Earth: A Traveling Exhibition

    Energy Technology Data Exchange (ETDEWEB)

    Booth, W.H.; Caesar, S.

    1992-09-01

    The Franklin Institute Science Museum provided an exhibit entitled the Greenhouse Earth: A Traveling Exhibition. This 3500 square-foot exhibit on global climate change was developed in collaboration with the Association of Science-Technology Centers. The exhibit opened at The Franklin Institute on February 14, 1992, welcoming 291,000 visitors over its three-month stay. During its three-year tour, Greenhouse Earth will travel to ten US cities, reaching two million visitors. Greenhouse Earth aims to deepen public understanding of the scientific issues of global warming and the conservation measures that can be taken to slow its effects. The exhibit features hands-on exhibitry, interactive computer programs and videos, a theater production, a demonstration cart,'' guided tours, and lectures. supplemental educational programs at the Institute included a teachers preview, a symposium on climate change, and a satellite field trip.'' The development of Greenhouse Earth included front-end and formative evaluation procedures. Evaluation includes interviews with visitors, prototypes, and summative surveys for participating museums. During its stay in Philadelphia, Greenhouse Earth was covered by the local and national press, with reviews in print and broadcast media. Greenhouse Earth is the first large-scale museum exhibit to address global climate change.

  9. [Insomnia and total sleep time in France: prevalence and associated socio-demographic factors in a general population survey].

    Science.gov (United States)

    Beck, F; Richard, J-B; Léger, D

    2013-12-01

    Sleep is considered as a major protective factor for good health and quality of life. The epidemiology of chronic insomnia and other sleep disorders has recently been developed in France. The aim of this study was to evaluate total sleep time and the prevalence of chronic insomnia in the general population aged 15 to 85 years. It was also to investigate factors associated with sleep disorders. Within the framework of the Health Barometer 2010, a French general population survey, 27,653 15 to 85-year-old individuals were questioned about their health behaviors and attitudes, in particular about their sleeping time and habits. The average sleeping time of the 15 to 85-year-old was 7 hours 13 minutes. It was higher for women than for men (7 hours 18 minutes vs 7 hours 07 minutes; Psocio-demographic characteristics. Since the beginning of 1990s, a single-question inquiry on "sleeping problems present during the last 8 days" has been asked in the Health Barometer. The rate of subjects concerned increased from 1995, with a prevalence stabilized at a high level since 2000. Based on these data, we think that the surveillance of sleep disorders is an important public health issue and that prevention and health educational initiatives should be launched in the general population to promote a better quality of sleep. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  10. [Differences in risk factors for disease and health problems between monks and the general population in The Netherlands].

    Science.gov (United States)

    van Meel, D; de Vrij, J H; Kunst, A E; Mackenbach, J P

    1992-08-08

    The aim of this study was to determine whether the austerely living Trappist and Benedictine monks have a lower prevalence of a number of risk factors and health problems than the general Dutch population. A written questionnaire was submitted to monks of 7 monasteries. The response was 67 per cent (134 monks). The data were compared with data from the national Health Interview Survey of 1989, which used an almost identical questionnaire. Adjustment was made for differences in age and education. Monks consume less alcohol and tobacco and have a more austere diet. Their average Quetelet index is lower. The prevalence of cardiovascular disease is lower. On the other hand, monks more often report a number of other chronic diseases, physical complaints, and problems with activities of daily life. They more often have contact with general practitioners and with consultants. The lower prevalence of a number of risk factors among monks reflects their austere way of life. It is not certain whether the lower prevalence of cardiovascular diseases can be attributed to this way of life. The fact that, in general, health problems are more prevalent among monks suggests that changes in lifestyle do not necessarily lead to compression of morbidity.

  11. Objective sleep structure and cardiovascular risk factors in the general population: the HypnoLaus Study.

    Science.gov (United States)

    Haba-Rubio, José; Marques-Vidal, Pedro; Andries, Daniela; Tobback, Nadia; Preisig, Martin; Vollenweider, Peter; Waeber, Gérard; Luca, Gianina; Tafti, Mehdi; Heinzer, Raphaël

    2015-03-01

    To evaluate the association between objective sleep measures and metabolic syndrome (MS), hypertension, diabetes, and obesity. Cross-sectional study. General population sample. There were 2,162 patients (51.2% women, mean age 58.4 ± 11.1). Patients were evaluated for hypertension, diabetes, overweight/obesity, and MS, and underwent a full polysomnography (PSG). PSG measured variables included: total sleep time (TST), percentage and time spent in slow wave sleep (SWS) and in rapid eye movement (REM) sleep, sleep efficiency and arousal index (ArI). In univariate analyses, MS was associated with decreased TST, SWS, REM sleep, and sleep efficiency, and increased ArI. After adjustment for age, sex, smoking, alcohol, physical activity, drugs that affect sleep and depression, the ArI remained significantly higher, but the difference disappeared in patients without significant sleep disordered breathing (SDB). Differences in sleep structure were also found according to the presence or absence of hypertension, diabetes, and overweight/obesity in univariate analysis. However, these differences were attenuated after multivariate adjustment and after excluding subjects with significant SDB. In this population-based sample we found significant associations between sleep structure and MS, hypertension, diabetes, and obesity. However, these associations were cancelled after multivariate adjustment. We conclude that normal variations in sleep contribute little if any to MS and associated disorders. © 2015 Associated Professional Sleep Societies, LLC.

  12. A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II.

    Science.gov (United States)

    Finkelstein, A; Kostrub, C F; Li, J; Chavez, D P; Wang, B Q; Fang, S M; Greenblatt, J; Burton, Z F

    1992-01-30

    RAP30/74 (also known as TFIIF, beta gamma and FC is one of several general factors required for initiation by RNA polymerase II. The small RAP30 subunit of RAP30/74 binds directly to polymerase and appears structurally and functionally homologous to bacterial sigma factors in their RNA polymerase-binding region. RAP30/74 or recombinant RAP30 suppresses nonspecific binding of RNA polymerase II to DNA and is required for RNA polymerase II to assemble stably into a preinitiation complex containing promoter DNA and the general factors TFIID, TFIIA and TFIIB; both RAP30 and RAP74 are physical components of the preinitiation complex. A complementary DNA encoding human RAP30 has been isolated, and here we report the isolation of a cDNA encoding human RAP74. RAP30 and RAP74 produced in Escherichia coli can be used in place of natural human RAP30/74 to direct accurate transcription initiation by RNA polymerase II in vitro.

  13. A STUDY OF RISK FACTORS IN STROKE PATIENTS IN GOVT., GENERAL HOSPITAL, KURNOOL, A.P

    Directory of Open Access Journals (Sweden)

    B.S. Isaac

    2013-10-01

    Full Text Available ABSTRACT : A study was undertaken on 50 patients admitted in Govt. General Hospital, Kurnool with acute cerebrovascular disease by using a pretested questionnaire. Parameters studied were age, sex, blood pressure, diabetes mellitus, smoking, alcohol, and hypercholesterolemia. 30(60% patients gave the history of hypertension in the past and were on treatment, apart from 10 more pa tients recorded a high blood pressure (>140/90 at the time of admission, making a total of 40(80% patients with hypertension. Out of 40 cases of hypertension, 30(75% had cerebral infarction and 10(25% had cerebral hemorrhage. 18 patients gave the hist ory of diabetes, and 14 more had blood sugar more than 140 mgs% at the time of admission, making a total of 32(64%. Out of 30 cases of diabetes, 20(66% had infarction and 10(33% had hemorrhage. 25 (50% patients were in the habit of smoking at a frequen cy of 5 - 25 cigarettes per day. Out of 25 patients with smoking 20(80% had infarction and 5(20% had hemorrhage. 16 patients gave the history of alcoholism. Out of which 7(43.7% had infarction and 9(56.3% had hemorrhage. Out of the 25 patients with smok ing habit 16 were hypertensive patients and 9 patients revealed raised serum cholesterol. Out of 16 patients with alcohol habit, 11 were hypertensive patients and 5 had raised serum cholesterol. Out of these 11 hypertensive patients 5 had infarction and 6 had hemorrhage. The 5 patients who had raised cholesterol 3 had infarction and 2 had hemorrhage. Out of the 32 diabetes cases, 21 had hypertension, and 11 had raised serum cholesterol. Out of 21 hypertensive’s, 12 had infarction and 9 had hemorrhage. Out o f 11 patients who had raised serum cholesterol, 8 had infarction and 3 had hemorrhage

  14. TB/HIV risk factors identified from a General Household Survey of South Africa in 2006.

    Science.gov (United States)

    Appunni, Sathiya Susuman; Blignaut, Renette; Lougue, Siaka

    2014-01-01

    The level of human immunodeficiency virus (HIV), tuberculosis (TB) as well as the co-infection TB/HIV in South Africa is among the highest in the world. TB is curable while HIV is not, yet the combination of both is a growing feature in the world. This study examined TB and HIV affecting people living in South Africa. Analyses have been undertaken based on data from the General Household Survey of South Africa in 2006. The study focused on respondents aged 15-49 years, corresponding to a total of 55,384 people composed of 25,859 males and 29,525 females. Among this population, 5935 people suffered from illness/injury, including 2469 (41.6%) males and 3466 (58.4%) females. Weighted multivariate logistic regression is performed on TB and/or HIV in association with the province, background characteristics of the target population, and selected socioeconomic and demographic variables included in the survey. In this study we focus on variables of health status and whether subjects suffered from TB and/or HIV. Findings of this investigation show that TB is the second most common cause of illness in the provinces of KwaZulu-Natal (KN) (9.1%), North West (5.4%) and Limpopo (4.2%). People who are married have a 50% lower risk compared to those currently not married to suffer from TB and/or HIV. Those with living spouses have a 5% lower risk to suffer from TB and/or HIV than those whose partners are not alive. This study concluded that rapid action is needed to curb the spread of TB and/or HIV to produce a healthy population. Therefore, follow-up care and special preventative measures are urgently needed in provinces with higher reported rates of TB and/or HIV such as KN.

  15. Impact of cerebral cardiopulmonary resuscitation maneuvers in a general hospital: prognostic factors and outcomes

    Directory of Open Access Journals (Sweden)

    Bartholomay Eduardo

    2003-01-01

    Full Text Available OBJECTIVE: To assess survival of patients undergoing cerebral cardiopulmonary resuscitation maneuvers and to identify prognostic factors for short-term survival. METHODS: Prospective study with patients undergoing cardiopulmonary resuscitation maneuvers. RESULTS: The study included 150 patients. Spontaneous circulation was re-established in 88 (58% patients, and 42 (28% were discharged from the hospital. The necessary number of patients treated to save 1 life in 12 months was 3.4. The presence of ventricular fibrillation or tachycardia (VF/VT as the initial rhythm, shorter times of cardiopulmonary resuscitation maneuvers and cardiopulmonary arrest, and greater values of mean blood pressure (BP prior to cardiopulmonary arrest were independent variables for re-establishment of spontaneous circulation and hospital discharge. The odds ratios for hospital discharge were as follows: 6.1 (95% confidence interval [CI] = 2.7-13.6, when the initial rhythm was VF/VT; 9.4 (95% CI = 4.1-21.3, when the time of cerebral cardiopulmonary resuscitation was 70 mmHg. CONCLUSION: The presence of VF/VT as the initial rhythm, shorter times of cerebral cardiopulmonary resuscitation and of cardiopulmonary arrest, and a greater value of BP prior to cardiopulmonary arrest were independent variables of better prognosis.

  16. A Rasch and factor analysis of the Functional Assessment of Cancer Therapy-General (FACT-G

    Directory of Open Access Journals (Sweden)

    Selby Peter J

    2007-04-01

    Full Text Available Abstract Background Although the Functional Assessment of Cancer Therapy – General questionnaire (FACT-G has been validated few studies have explored the factor structure of the instrument, in particular using non-sample dependent measurement techniques, such as Rasch Models. Furthermore, few studies have explored the relationship between item fit to the Rasch Model and clinical utility. The aim of this study was to investigate the dimensionality and measurement properties of the FACT-G with Rasch Models and Factor analysis. Methods A factor analysis and Rasch analysis (Partial Credit Model was carried out on the FACT-G completed by a heterogeneous sample of cancer patients (n = 465. For the Rasch analysis item fit (infit mean squares ≥ 1.30, dimensionality and item invariance were assessed. The impact of removing misfitting items on the clinical utility of the subscales and FACT-G total scale was also assessed. Results The factor analysis demonstrated a four factor structure of the FACT-G which broadly corresponded to the four subscales of the instrument. Internal consistency for these four scales was very good (Cronbach's alpha 0.72 – 0.85. The Rasch analysis demonstrated that each of the subscales and the FACT-G total scale had misfitting items (infit means square ≥ 1.30. All these scales with the exception of the Social & Family Well-being Scale (SFWB were unidimensional. When misfitting items were removed, the effect sizes and the clinical utility of the instrument were maintained for the subscales and the total FACT-G scores. Conclusion The results of the traditional factor analysis and Rasch analysis of the FACT-G broadly agreed. Caution should be exercised when utilising the Social & Family Well-being scale and further work is required to determine whether this scale is best represented by two factors. Additionally, removing misfitting items from scales should be performed alongside an assessment of the impact on clinical utility.

  17. Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.

    Directory of Open Access Journals (Sweden)

    Aron K Barbey

    Full Text Available Brain-derived neurotrophic factor (BDNF promotes survival and synaptic plasticity in the human brain. The Val66Met polymorphism of the BDNF gene interferes with intracellular trafficking, packaging, and regulated secretion of this neurotrophin. The human prefrontal cortex (PFC shows lifelong neuroplastic adaption implicating the Val66Met BDNF polymorphism in the recovery of higher-order executive functions after traumatic brain injury (TBI. In this study, we examined the effect of this BDNF polymorphism on the preservation of general intelligence following TBI. We genotyped a sample of male Vietnam combat veterans (n = 156 consisting of a frontal lobe lesion group with focal penetrating head injuries for the Val66Met BDNF polymorphism. Val/Met did not differ from Val/Val genotypes in general cognitive ability before TBI. However, we found substantial average differences between these groups in general intelligence (≈ half a standard deviation or 8 IQ points, verbal comprehension (6 IQ points, perceptual organization (6 IQ points, working memory (8 IQ points, and processing speed (8 IQ points after TBI. These results support the conclusion that Val/Met genotypes preserve general cognitive functioning, whereas Val/Val genotypes are largely susceptible to TBI.

  18. Musculoskeletal symptoms as related to ergonomic factors in Iranian hand-woven carpet industry and general guidelines for workstation design.

    Science.gov (United States)

    Choobineh, Alireza; Lahmi, Mohammadali; Shahnavaz, Houshang; Jazani, Reza Khani; Hosseini, Mostafa

    2004-01-01

    Carpet weaving is a high risk occupation for developing musculoskeletal disorders (MSDs). The objectives of the present study, which was carried out in the Iranian hand-woven carpet industry, were determination of the prevalence of MSD symptoms, identification of major factors associated with MSD symptoms and development of guidelines for workstation design. 1,439 randomly selected weavers participated in this study. A questionnaire was used to collect data on MSD symptoms. The results revealed that the prevalence rates for symptoms in different body regions were high as compared to the general Iranian population (for neck, back and large joints, p loom type, working posture, daily working time and seat type. Based on the results, some general guidelines for designing weaving workstations were developed. A prototype test showed that the new workstation was acceptable for subject tests and that it improved working posture.

  19. Factors associated with nonattendance at clinical medicine scheduled outpatient appointments in a university general hospital

    Directory of Open Access Journals (Sweden)

    Giunta D

    2013-11-01

    Full Text Available Diego Giunta,1,2 Agustina Briatore,3 Analía Baum,3 Daniel Luna,3 Gabriel Waisman,2 Fernán Gonzalez Bernaldo de Quiros1–31Internal Medicine Research Unit, 2Internal Medicine Department, 3Health Informatics Department, Hospital Italiano de Buenos Aires, Buenos Aires, ArgentinaIntroduction: Nonattendance at scheduled outpatient appointments for primary care is a major health care problem worldwide. Our aim was to estimate the prevalence of nonattendance at scheduled appointments for outpatients seeking primary care, to identify associated factors and build a model that predicts nonattendance at scheduled appointments.Methods: A cohort study of adult patients, who had a scheduled outpatient appointment for primary care, was conducted between January 2010 and July 2011, at the Italian Hospital of Buenos Aires. We evaluated the history and characteristics of these patients, and their scheduling and attendance at appointments. Patients were divided into two groups: those who attended their scheduled appointments, and those who did not. We estimated the odds ratios (OR and corresponding 95% confidence intervals (95% CI, and generated a predictive model for nonattendance, with logistic regression, using factors associated with lack of attendance, and those considered clinically relevant. Alternative models were compared using Akaike's Information Criterion. A generation cohort and a validation cohort were assigned randomly.Results: Of 113,716 appointments included in the study, 25,687 were missed (22.7%; 95% CI: 22.34%–22.83%. We found a statistically significant association between nonattendance and age (OR: 0.99; 95% CI: 0.99–0.99, number of issues in the personal health record (OR: 0.98; 95% CI: 0.98–0.99, time between the request for and date of appointment (OR: 1; 95% CI: 1–1, history of nonattendance (OR: 1.07; 95% CI: 1.07–1.07, appointment scheduled later than 4 pm (OR: 1.30; 95% CI: 1.24–1.35, and specific days of the week (OR: 1

  20. Are Cancer Patients' Socioeconomic and Cultural Factors Associated with Contact to General Practitioners in the Last Phase of Life?

    DEFF Research Database (Denmark)

    Neergaard, M A; Olesen, Frede; Sondergaard, J;

    2015-01-01

    Introduction. General practitioners (GPs) play an important role in end of life care, which should be offered regardless of socioeconomic position and cultural factors. The aim was to analyse associations between GP contacts at the end of life and socioeconomic and cultural characteristics...... of Danish cancer patients. Method. Population-based study identifying 599 adults who died of cancer from March to November 2006, in Aarhus County, Denmark. Associations between health register-based data on "total GP face-to-face contacts" and "GP home visits" during the last 90 days of life and patients...

  1. FACTORES DE RIESGO PARA MORTALIDAD CARDIOVASCULAR Y GENERAL EN LOS PACIENTES CON ENFERMEDAD RENAL CRÓNICA TERMINAL

    OpenAIRE

    Pérez Molina, Jorge Lenin

    2012-01-01

    La enfermedad renal crónica (ERC) constituye un problema de salud pública con alta incidencia y prevalencia y amplia gama de complicaciones que conllevan a un aumento en la mortalidad en pacientes con diálisis. La mortalidad por enfermedad cardiovascular (ECV) es hasta 20 veces más frecuente en esta población. Objetivo: Identificar los factores de riesgo para mortalidad cardiovascular y general en los pacientes con enfermedad renal crónica terminal (ERCT) que se encuentren b...

  2. Prevalencia y factores asociados a desnutrición hospitalaria en un hospital general: Perú, 2012

    OpenAIRE

    L. E. Veramendi-Espinoza; J. H. Zafra-Tanaka; O. Salazar-Saavedra; J. E. Basilio-Flores; E. Millones-Sánchez; G. A. Pérez-Casquino; L. M. Quispe-Moore; M. E. Tapia-Vicente; D. I. Ticona-Rebagliati; N. B. Asato; L. Quispe-Calderón; H. J. Ruiz García; A. Chia-Gil; D. E. Rey-Rodríguez; B. T. Surichaqui

    2013-01-01

    Introducción: La desnutrición hospitalaria es un problema prevalente que genera mayor morbi-mortalidad, peor respuesta al tratamiento, mayor estancia y costo hospitalario. Objetivos: Determinar la prevalencia y factores asociados a desnutrición hospitalaria en un hospital general peruano. Métodos: Estudio analítico transversal de 211 pacientes en servicios de Medicina y Cirugía. Se analizó variables demográficas, clínicas e indicadores antropométricos. El análisis multivariado fue de regresió...

  3. Generalized Measure of Departure from No Three-Factor Interaction Model for 2 x 2 x K Contingency Tables

    Directory of Open Access Journals (Sweden)

    Yohei Ban

    2008-12-01

    Full Text Available For 2 x 2 x K contingency tables, Tomizawa considered a Shannon entropy type measure to represent the degree of departure from a log-linear model of no three-factor interaction (the NOTFI model. This paper proposes a generalization of Tomizawa's measure for 2 x 2 x K tables. The measure proposed is expressed by using Patil-Taillie diversity index or Cressie-Read power-divergence. A special case of the proposed measure includes Tomizawa's measure. The proposed measure would be useful for comparing the degrees of departure from the NOTFI model in several tables.

  4. El factor general del Rey y las finanzas de la Monarquía Hispánica

    OpenAIRE

    Álvarez Nogal, Carlos

    1999-01-01

    Editada en la Fundación Empresa Pública En este artículo se estudia la figura del Factor General del rey dentro de la organización y funcionamiento de la Real Hacienda castellana entre 1627 y 1644, coincidiendo con el gobierno reformista del Conde-duque de Olivares. Durante esos años, el desempeño de este cargo recayó en Bartolomé Spinola, uno de los más importantes hombres de negocios genoveses del reinado de Felipe IV. El estudio aborda cómo se organizó la gestión de los r...

  5. Measurement of the generalized form factors near threshold via $\\gamma^* p \\to n\\pi^+$ at high $Q^2$

    CERN Document Server

    Park, Kijun; Adhikari, Krishna; Adikaram-Mudiyanselage, Dasuni; Anghinolfi, Marco; Baghdasaryan, Hovhannes; Ball, Jacques; Battaglieri, Marco; Baturin, Vitaly; Bedlinskiy, Ivan; Bennett, Robert; Biselli, Angela; Bookwalter, Craig; Boyarinov, Sergey; Branford, Derek; Briscoe, William; Brooks, William; Burkert, Volker; Carman, Daniel; Celentano, Andrea; Chandavar, Shloka; Charles, Gabriel; Cole, Philip; Contalbrigo, Marco; Crede, Volker; D'Angelo, Annalisa; Daniel, Aji; Dashyan, Natalya; De Vita, Raffaella; De Sanctis, Enzo; Deur, Alexandre; Djalali, Chaden; Doughty, David; Dupre, Raphael; Alaoui, Ahmed El; Elfassi, Lamiaa; Eugenio, Paul; Fedotov, Gleb; Fradi, Ahmed; Gabrielyan, Marianna; Gevorgyan, Nerses; Gilfoyle, Gerard; Giovanetti, Kevin; Girod, Francois-Xavier; Goetz, John; Gohn, Wesley; Golovach, Evgeny; Graham, Lewis; Griffioen, Keith; Guidal, Michel; Guo, Lei; Hafidi, Kawtar; Hakobyan, Hayk; Hanretty, Charles; Heddle, David; Hicks, Kenneth; Holtrop, Maurik; Ilieva, Yordanka; Ireland, David; Ishkhanov, Boris; Isupov, Evgeny; Jenkins, David; Jo, Hyon-Suk; Joo, Kyungseon; Khandaker, Mahbubul; Khetarpal, Puneet; Kim, Andrey; Kim, Wooyoung; Klein, Andreas; Klein, Franz; Kubarovsky, A; Kubarovsky, Valery; Kuhn, Sebastian; Kuleshov, Sergey; Kvaltine, Nicholas; Livingston, Kenneth; Lu, Haiyun; MacGregor, Ian; Markov, Nikolai; Mayer, Michael; McKinnon, Bryan; Mestayer, Mac; Meyer, Curtis; Mineeva, Taisiya; Mirazita, Marco; Mokeev, Viktor; Moutarde, Herve; Espitia, Edwin Munevar; Nadel-Turonski, Pawel; Nasseripour, Rakhsha; Niccolai, Silvia; Niculescu, Gabriel; Niculescu, Maria-Ioana; Osipenko, Mikhail; Ostrovidov, Alexander; Paolone, Michael; Pappalardo, Luciano; Paremuzyan, Rafayel; Park, Seungkyung; Pereira, Sergio; Phelps, Evan; Pisano, Silvia; Pogorelko, Oleg; Pozdnyakov, Sergey; Price, John; Procureur, Sebastien; Prok, Yelena; Ricco, Giovanni; Rimal, Dipak; Ripani, Marco; Ritchie, Barry; Rosner, Guenther; Rossi, Patrizia; Sabatie, Franck; Saini, Mukesh; Salgado, Carlos; Schott, Diane; Schumacher, Reinhard; Seraydaryan, Heghine; Sharabian, Youri; Smith, Elton; Smith, Gregory; Sober, Daniel; Sokhan, Daria; Stepanyan, Samuel; Stepanyan, Stepan; Stoler, Paul; Strakovski, Igor; Strauch, Steffen; Taiuti, Mauro; Tang, Wei; Taylor, Charles; Tian, Ye; Tkachenko, Svyatoslav; Trivedi, Arjun; Ungaro, Maurizio; Vernarsky, Brian; Vlasov, Alexander; Voutier, Eric; Watts, Daniel; Weygand, Dennis; Wood, Michael; Zachariou, Nicholas; Zhao, Bo; Zhao, Zhiwen; Kalantarians, N; Hyde, C E

    2012-01-01

    We report the first extraction of the pion-nucleon multipoles near the production threshold for the $n\\pi^+$ channel at relatively high momentum transfer ($Q^2$ up to 4.2 $\\rm{GeV^2}$). The dominance of the s-wave transverse multipole ($E_{0+}$), expected in this region, allowed us to access the generalized form factor $G_1$ within the light-cone sum rule (LCSR) framework as well as the axial form factor $G_A$. The data analyzed in this work were collected by the nearly $4\\pi$ CEBAF Large Acceptance Spectrometer (CLAS) using a 5.754 $\\rm{GeV}$ electron beam on a proton target. The differential cross section and the $\\pi-N$-multipole $E_{0+}/G_D$ were measured using two different methods, the LCSR and a direct multipole fit. The results from the two methods are found to be consistent and almost $Q^2$ independent.

  6. Deriving amplification factors from simple site parameters using generalized regression neural networks: implications for relevant site proxies

    Science.gov (United States)

    Boudghene Stambouli, Ahmed; Zendagui, Djawad; Bard, Pierre-Yves; Derras, Boumédiène

    2017-07-01

    Most modern seismic codes account for site effects using an amplification factor (AF) that modifies the rock acceleration response spectra in relation to a "site condition proxy," i.e., a parameter related to the velocity profile at the site under consideration. Therefore, for practical purposes, it is interesting to identify the site parameters that best control the frequency-dependent shape of the AF. The goal of the present study is to provide a quantitative assessment of the performance of various site condition proxies to predict the main AF features, including the often used short- and mid-period amplification factors, Fa and Fv, proposed by Borcherdt (in Earthq Spectra 10:617-653, 1994). In this context, the linear, viscoelastic responses of a set of 858 actual soil columns from Japan, the USA, and Europe are computed for a set of 14 real accelerograms with varying frequency contents. The correlation between the corresponding site-specific average amplification factors and several site proxies (considered alone or as multiple combinations) is analyzed using the generalized regression neural network (GRNN). The performance of each site proxy combination is assessed through the variance reduction with respect to the initial amplification factor variability of the 858 profiles. Both the whole period range and specific short- and mid-period ranges associated with the Borcherdt factors Fa and Fv are considered. The actual amplification factor of an arbitrary soil profile is found to be satisfactorily approximated with a limited number of site proxies (4-6). As the usual code practice implies a lower number of site proxies (generally one, sometimes two), a sensitivity analysis is conducted to identify the "best performing" site parameters. The best one is the overall velocity contrast between underlying bedrock and minimum velocity in the soil column. Because these are the most difficult and expensive parameters to measure, especially for thick deposits, other

  7. Exhibition - Mathematics, A Beautiful Elsewhere

    CERN Multimedia

    2011-01-01

    From 21 October 2011 to 18 March 2012, the Fondation Cartier pour l’art contemporain will present the exhibition Mathematics: A Beautiful Elsewhere, an exhibition developed in association with the Institut des Hautes Études Scientifiques (IHÉS) and under the patronage of UNESCO. For this unprecedented event, the foundation invited mathematicians to work with artists with whom it has previously worked to create an exhibition that allows visitors to see, hear, do, interpret and think about mathematics. By bringing mathematics into its premises, the Fondation Cartier is itself undergoing the “sudden change of scenery” described by mathematician Alexandre Grothendieck. More information is available here. Fondation Cartier pour l’art contemporain 261, boulevard Raspail 75014 Paris http://fondation.cartier.com Private Visit For professors, researchers and all the staff of Mathematics departments...

  8. Contributing factors to influenza vaccine uptake in general hospitals: an explorative management questionnaire study from the Netherlands

    Directory of Open Access Journals (Sweden)

    Riphagen-Dalhuisen Josien

    2012-12-01

    Full Text Available Abstract Background The influenza vaccination rate in hospitals among health care workers in Europe remains low. As there is a lack of research about management factors we assessed factors reported by administrators of general hospitals that are associated with the influenza vaccine uptake among health care workers. Methods All 81 general hospitals in the Netherlands were approached to participate in a self-administered questionnaire study. The questionnaire was directed at the hospital administrators. The following factors were addressed: beliefs about the effectiveness of the influenza vaccine, whether the hospital had a written policy on influenza vaccination and how the hospital informed their staff about influenza vaccination. The questionnaire also included questions about mandatory vaccination, whether it was free of charge and how delivered as well as the vaccination campaign costs. The outcome of this one-season survey is the self-reported overall influenza vaccination rate of health care workers. Results In all, 79 of 81 hospitals that were approached were willing to participate and therefore received a questionnaire. Of these, 42 were returned (response rate 52%. Overall influenza vaccination rate among health care workers in our sample was 17.7% (95% confidence interval: 14.6% to 20.8%. Hospitals in which the administrators agreed with positive statements concerning the influenza vaccination had a slightly higher, but non-significant, vaccine uptake. There was a 9% higher vaccine uptake in hospitals that spent more than €1250,- on the vaccination campaign (24.0% versus 15.0%; 95% confidence interval from 0.7% to 17.3%. Conclusions Agreement with positive statements about management factors with regard to influenza vaccination were not associated with the uptake. More economic investments were related with a higher vaccine uptake; the reasons for this should be explored further.

  9. Prevalencia de factores de riesgo de enfermedad coronaria en trabajadores del Hospital General de México Prevalence of risk factors of coronary disease in personnel of the General Hospital of Mexico

    Directory of Open Access Journals (Sweden)

    GUILLERMO FANGHÄNEL-SALMÓN

    1997-09-01

    Full Text Available Objetivo. Conocer la prevalencia de algunos factores de riesgo coronario en trabajadores de una institución de salud. Material y métodos. De 1993 a 1995 se evaluaron 2 228 trabajadores del Hospital General de México, 1 531 mujeres (68.7% y 697 hombres (31.2% con edades entre 16 a 65 años, y se les clasificó por áreas de trabajo: en Intendencia hubo 477 participantes (21.4%; en Administración, 697 (31.2%; en Personal Médico, 495 (22.2%, y en Enfermería, 559 (25.0%. Se les practicó historia clínica, mediciones antropométricas y determinación de glucosa, colesterol total, LDL, HDL y triglicéridos. Resultados. Trescientos sesenta y siete sujetos (14.9% tenían colesterol por arriba de 240 mg/dl, con valores altos en las mujeres del área administrativa (17.1% y en los hombres del departamento de enfermería (26% que presentó la mayor tendencia (26%. Se encontraron niveles de triglicéridos por arriba de los 200 mg/dl en 471 personas (19.1%; obesidad, en 329 (13.5%; hipertensión arterial, en 549 sujetos (22.2%, y tabaquismo positivo, en 32% de los trabajadores. La prevalencia de diabetes mellitus fue de 6.24%. Conclusiones. Se confirma la elevada prevalencia de factores de riesgo de enfermedad cardiovascular entre los trabajadores del Hospital General de México, factores que en muchos casos son modificables, lo que confiere la posibilidad de realizar acciones preventivas.Objective. To evaluate the prevalence of risk factors of coronary heart disease in the personnel of the General Hospital in Mexico City. Material and methods. We studied 2 228 workers, 1 531 female (68.7% and 697 male (31.2% whose ages ranged from 16 to 65 years old in the period of 1993 to 1995. They were divided in work areas: Intendancy 477 (21.4%, Administrative, 697 (31.2%, Physicians, 495 (22.2% and Nurses, 559 (25.0%. We collected clinical histories, anthropometric measures, and laboratory determinations of glucose, total cholesterol, LDL, HDL and

  10. Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis

    Science.gov (United States)

    Zhang, Zhengjian; English, Brian P.; Grimm, Jonathan B.; Kazane, Stephanie A.; Hu, Wenxin; Tsai, Albert; Inouye, Carla; You, Changjiang; Piehler, Jacob; Schultz, Peter G.; Lavis, Luke D.; Revyakin, Andrey; Tjian, Robert

    2016-01-01

    Transcription of protein-encoding genes in eukaryotic cells requires the coordinated action of multiple general transcription factors (GTFs) and RNA polymerase II (Pol II). A “step-wise” preinitiation complex (PIC) assembly model has been suggested based on conventional ensemble biochemical measurements, in which protein factors bind stably to the promoter DNA sequentially to build a functional PIC. However, recent dynamic measurements in live cells suggest that transcription factors mostly interact with chromatin DNA rather transiently. To gain a clearer dynamic picture of PIC assembly, we established an integrated in vitro single-molecule transcription platform reconstituted from highly purified human transcription factors and complemented it by live-cell imaging. Here we performed real-time measurements of the hierarchal promoter-specific binding of TFIID, TFIIA, and TFIIB. Surprisingly, we found that while promoter binding of TFIID and TFIIA is stable, promoter binding by TFIIB is highly transient and dynamic (with an average residence time of 1.5 sec). Stable TFIIB–promoter association and progression beyond this apparent PIC assembly checkpoint control occurs only in the presence of Pol II–TFIIF. This transient-to-stable transition of TFIIB-binding dynamics has gone undetected previously and underscores the advantages of single-molecule assays for revealing the dynamic nature of complex biological reactions. PMID:27798851

  11. Recruitment difficulties in a primary care cluster randomised trial: investigating factors contributing to general practitioners' recruitment of patients

    Directory of Open Access Journals (Sweden)

    McKenzie Joanne E

    2011-03-01

    Full Text Available Abstract Background Recruitment of patients by health professionals is reported as one of the most challenging steps when undertaking studies in primary care settings. Numerous investigations of the barriers to patient recruitment in trials which recruit patients to receive an intervention have been published. However, we are not aware of any studies that have reported on the recruitment barriers as perceived by health professionals to recruiting patients into cluster randomised trials where patients do not directly receive an intervention. This particular subtype of cluster trial is commonly termed a professional-cluster trial. The aim of this study was to investigate factors that contributed to general practitioners recruitment of patients in a professional-cluster trial which evaluated the effectiveness of an intervention to increase general practitioners adherence to a clinical practice guideline for acute low-back pain. Method General practitioners enrolled in the study were posted a questionnaire, consisting of quantitative items and an open-ended question, to assess possible reasons for poor patient recruitment. Descriptive statistics were used to summarise quantitative items and responses to the open-ended question were coded into categories. Results Seventy-nine general practitioners completed at least one item (79/94 = 84%, representing 68 practices (85% practice response rate, and 44 provided a response to the open-ended question. General practitioners recalled inviting a median of two patients with acute low-back pain to participate in the trial over a seven-month period; they reported that they intended to recruit patients, but forgot to approach patients to participate; and they did not perceive that patients had a strong interest or disinterest in participating. Additional open-ended comments were generally consistent with the quantitative data. Conclusion A number of barriers to the recruitment of patients with acute low

  12. Generalized window factor analysis for selective analysis of the target component in real samples with complex matrices.

    Science.gov (United States)

    Li, Pao; Cai, Wensheng; Shao, Xueguang

    2015-08-14

    In chromatographic analysis of multicomponent real samples, peak overlapping, high level of noise and background are frequently encountered, making the qualitative and quantitative analysis difficult or even impossible. In this work, an algorithm named as generalized window factor analysis (GWFA) was proposed for quantitative analysis of the target components in the samples with complex matrices by gas chromatography-mass spectrometry (GC-MS). The theory and calculation of GWFA are just similar with the conventional window factor analysis (WFA), but the "window" is defined as the selected channels (mass-to-charge ratios) in the mass spectral dimension of the data matrix, instead of a continuous region in chromatographic dimension along the retention time. Therefore, the generalized window for a target component can be easily determined with the help of the mass spectrum. Then, the calculated mass spectrum can be obtained with the window and quantitative determination can be achieved with the help of the standard. Both simulated and experimental data were investigated with the proposed method. Whether or not a peak shift occurs during the test, accurate results were obtained from the overlapping GC-MS signals with high level of noise and background.

  13. Assessment of the factor structure and reliability of the Portuguese version of the General Health Questionnaire-28 among adults.

    Science.gov (United States)

    De Almeida Vieira Monteiro, Ana Paula Teixeira

    2011-02-01

    The General Health Questionnaire (GHQ, Goldberg & Hillier, 1979 , Psychological Medicine, 9, 139-145) is a self-administered questionnaire used to measure non-psychotic psychiatric disorders. There is a study using a Portuguese version of this questionnaire (n = 60) including a group of inpatients with infectious diseases (Ribeiro & Antunes, 2003 , Revista Portuguesa de Psicossomática, 5(1), 37-45), but there are no larger studies in non-clinical Portuguese population. The primary aim of the study was to confirm the psychometric properties of the Portuguese version of the GHQ-28 among 171 Portuguese adults in non-clinical settings. The Portuguese version of the GHQ-28 was administered to 171 adult subjects of Portuguese general population. The Portuguese version of the GHQ-28 has an internally consistent measure Cronbach's α 0.922 for the GHQ-28 total scale. For the subscale somatic symptoms Cronbach's α was 0.825; for the subscale Anxiety/ Insomnia, Cronbach's α was 0.873; for the subscale Social dysfunction Cronbach's α was 0.873 and for the subscale Severe Depression was 0.838. Four factors were extracted using factor analysis: somatic symptoms (items 1-7); anxiety/insomnia (items 8-14); psychosocial dysfunction (items 15-21); and severe depression (items 22-28). The findings suggest that the GHQ-28 is a suitable screening instrument for adult Portuguese population in non-clinical settings.

  14. Science anxiety and social cognitive factors predicting STEM career aspirations of high school freshmen in general science class

    Science.gov (United States)

    Skells, Kristin Marie

    Extant data was used to consider the association between science anxiety, social cognitive factors and STEM career aspirations of high school freshmen in general science classes. An adapted model based on social cognitive career theory (SCCT) was used to consider these relationships, with science anxiety functioning as a barrier in the model. The study assessed the following research questions: (1) Do social cognitive variables relate in the expected way to STEM career aspirations based on SCCT for ninth graders taking general science classes? (2) Is there an association between science anxiety and outcomes and processes identified in the SCCT model for ninth graders taking general science classes? (3) Does gender moderate these relationships? Results indicated that support was found for many of the central tenants of the SCCT model. Science anxiety was associated with prior achievement, self-efficacy, and science interest, although it did not relate directly to STEM career goals. Gender was found to moderate only the relationship between prior achievement and science self-efficacy.

  15. Exhibiting eugenics: response and resistance to a hidden history.

    Science.gov (United States)

    Brave, Ralph; Sylva, Kathryn

    2007-01-01

    Human Plants, Human Harvest: The Hidden History of California Eugenics is the first-ever exhibition on the history of eugenics in California. The disappearance of this history for half a century, and the consequent absence of a "collective menory", were the primary factors determining the exhibit's sttrcture and content. Responses to the exhibit confirmed that most visitors "never knew" about this history. The exhibit is described in some detail, with selected imagery from the exhibit reproduced. After the initial exhibition, responses of other museums and foundation officials revealed a continuing resistance to this history being publicly displayed, though the sources of resistance varied.

  16. CERN exhibition attracts over 100,000 visitors in Belgrade

    CERN Multimedia

    Antonella Del Rosso

    2012-01-01

    “This must be an 'all-time record',” says Ray Lewis, CERN travelling exhibition manager. “In all my time with the various permanent and travelling exhibitions that have taken place locally and within our Member States I have never experienced such figures.”   Zarko Obradovic (left), Serbian Minister of Education, Science and Technology, and Rolf Heuer (right), CERN Director-General, at the CERN travelling exhibition in Belgrade. Indeed, in approximately 20 days of exhibition time about 120,000 people, mainly school visiters and the general public, visited the 100 m2 CERN mini-exhibition. It was set up in the centre of Belgrade in October, in association with the meeting of the Restricted European Committee for Future Accelerators (RECFA). After attending the RECFA meeting, CERN's Director-General Rofl Heuer opened the CERN exhibition on the evening of 19 October. Lectures about CERN were held every afternoon, and two public de...

  17. Prevalence and factors associated with diabetic retinopathy among diabetic patients at Arbaminch General Hospital, Ethiopia: Cross sectional study

    Science.gov (United States)

    Chisha, Yilma; Terefe, Wondwossen; Assefa, Huruy; Lakew, Serawit

    2017-01-01

    Background Currently 93 million people are estimated as living with diabetic retinopathy worldwide. The prevalence and risk factors of diabetic retinopathy in developed countries have been well documented; but in Ethiopia, data on prevalence and associated factors of diabetic retinopathy is lacking. Objective To determine prevalence and factors associated with development of diabetic retinopathy among diabetic patients at Arbaminch General Hospital, Ethiopia. Method Cross-sectional study design with record review of 400 diabetic patients was conducted at Arbaminch General Hospital from November to January 2015. Among 400 diabetic patients, 270 patients with baseline information and without history of hypertension at baseline were included in this study. But patients with gestational diabetes and with retinopathy at baseline were excluded from the study. Consecutive sampling technique was applied to select study participants. Data of cohorts was extracted from medical record using pre tested structured extraction check list. Data cleaning, coding, categorizing, merging and analysis carried out by STATA version 12. Descriptive statistics was done and presented accordingly. Bivariate binary logistic regression analysis was done to select potential candidates for the full model at P-value cutoff point ≤ 0.25 and multivariable binary logistic regression analysis was made to estimate the independent effect of predictors on the occurrence of diabetic retinopathy. Model diagnostic tests were done, final model fitness was checked using Hosmer and Lemeshow chi square test. Finally, statistical significance was tested at P-value 140 mmhg, duration of diabetes ≥6 years and patients with family history of diabetes were statistically and significantly related with diabetic retinopathy, special care should be given in addition to routine care. PMID:28253261

  18. Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest

    Directory of Open Access Journals (Sweden)

    Bismut Françoise

    2010-04-01

    Full Text Available Abstract Background FibroTest and elastography have been validated as biomarkers of liver fibrosis in the most frequent chronic liver diseases and in the fibrosis screening of patients with diabetes. One challenge was to use them for estimating the prevalence of fibrosis, identifying independent risk factors and to propose screening strategies in the general population. Methods We prospectively studied 7,463 consecutive subjects aged 40 years or older. Subjects with presumed advanced fibrosis (FibroTest greater than 0.48 were re-investigated in a tertiary center. Results The sample characteristics were similar to those of the French population. FibroTest was interpretable in 99.6%. The prevalence of presumed fibrosis was 2.8%, (209/7,463, including cirrhosis in 0.3% (25/7,463; 105/209 (50% subjects with presumed fibrosis accepted re-investigation. Fibrosis was confirmed in 50, still suspected in 27, indeterminate in 25 and not confirmed with false positive FibroTest or false negative elastography in 3 subjects. False negative rate of FibroTest estimated using elastography was 0.4% (3/766. The attributable causes for confirmed fibrosis were both alcoholic and nonalcoholic fatty liver disease (NAFLD in 66%, NAFLD in 13%, alcohol in 9%, HCV in 6%, and other in 6%. Factors independently associated (all P Conclusions Biomarkers have permitted to estimate prevalence of advanced fibrosis around 2.8% in a general population aged 40 years or older, and several risk factors which may be used for the validation of selective or non-selective screening strategies.

  19. Prevalencia de factores de riesgo de enfermedad coronaria en trabajadores del Hospital General de México

    Directory of Open Access Journals (Sweden)

    FANGHÄNEL-SALMÓN GUILLERMO

    1997-01-01

    Full Text Available Objetivo. Conocer la prevalencia de algunos factores de riesgo coronario en trabajadores de una institución de salud. Material y métodos. De 1993 a 1995 se evaluaron 2 228 trabajadores del Hospital General de México, 1 531 mujeres (68.7% y 697 hombres (31.2% con edades entre 16 a 65 años, y se les clasificó por áreas de trabajo: en Intendencia hubo 477 participantes (21.4%; en Administración, 697 (31.2%; en Personal Médico, 495 (22.2%, y en Enfermería, 559 (25.0%. Se les practicó historia clínica, mediciones antropométricas y determinación de glucosa, colesterol total, LDL, HDL y triglicéridos. Resultados. Trescientos sesenta y siete sujetos (14.9% tenían colesterol por arriba de 240 mg/dl, con valores altos en las mujeres del área administrativa (17.1% y en los hombres del departamento de enfermería (26% que presentó la mayor tendencia (26%. Se encontraron niveles de triglicéridos por arriba de los 200 mg/dl en 471 personas (19.1%; obesidad, en 329 (13.5%; hipertensión arterial, en 549 sujetos (22.2%, y tabaquismo positivo, en 32% de los trabajadores. La prevalencia de diabetes mellitus fue de 6.24%. Conclusiones. Se confirma la elevada prevalencia de factores de riesgo de enfermedad cardiovascular entre los trabajadores del Hospital General de México, factores que en muchos casos son modificables, lo que confiere la posibilidad de realizar acciones preventivas.

  20. The contribution of demographic and morbidity factors to self-reported visit frequency of patients: a cross-sectional study of general practice patients in Australia

    Directory of Open Access Journals (Sweden)

    Britt Helena

    2004-08-01

    Full Text Available Abstract Background Understanding the factors that affect patients' utilisation of health services is important for health service provision and effective patient management. This study aimed to investigate the specific morbidity and demographic factors related to the frequency with which general practice patients visit a general practitioner/family physician (GP in Australia. Methods A sub-study was undertaken as part of an ongoing national study of general practice activity in Australia. A cluster sample of 10,755 general practice patients were surveyed through a random sample of 379 general practitioners. The patient reported the number of times he/she had visited a general practitioner in the previous twelve months. The GP recorded all the patient's major health problems, including those managed at the current consultation. Results Patients reported an average of 8.8 visits to a general practitioner per year. After adjusting for other patient demographics and number of health problems, concession health care card holders made on average 2.6 more visits per year to a general practitioner than did non-card holders (p Conclusions Anxiety, back pain and depression are associated with greater patient demand for general practice services than other health problems. The effect of sociodemographic factors on patient utilisation of general practice services is complex. Equity of access to general practice services remains an issue for patients from remote areas, while concession health care card holders are attending general practice more frequently than other patients relative to their number of health problems.

  1. Thoracic spine pain in the general population: Prevalence, incidence and associated factors in children, adolescents and adults. A systematic review

    Directory of Open Access Journals (Sweden)

    Straker Leon M

    2009-06-01

    Full Text Available Abstract Background Thoracic spine pain (TSP is experienced across the lifespan by healthy individuals and is a common presentation in primary healthcare clinical practice. However, the epidemiological characteristics of TSP are not well documented compared to neck and low back pain. A rigorous evaluation of the prevalence, incidence, correlates and risk factors needs to be undertaken in order for epidemiologic data to be meaningfully used to develop evidence-based prevention and treatment recommendations for TSP. Methods A systematic review method was followed to report the evidence describing prevalence, incidence, associated factors and risk factors for TSP among the general population. Nine electronic databases were systematically searched to identify studies that reported either prevalence, incidence, associated factors (cross-sectional study or risk factors (prospective study for TSP in healthy children, adolescents or adults. Studies were evaluated for level of evidence and method quality. Results Of the 1389 studies identified in the literature, 33 met the inclusion criteria for this systematic review. The mean (SD quality score (out of 15 for the included studies was 10.5 (2.0. TSP prevalence data ranged from 4.0–72.0% (point, 0.5–51.4% (7-day, 1.4–34.8% (1-month, 4.8–7.0% (3-month, 3.5–34.8% (1-year and 15.6–19.5% (lifetime. TSP prevalence varied according to the operational definition of TSP. Prevalence for any TSP ranged from 0.5–23.0%, 15.8–34.8%, 15.0–27.5% and 12.0–31.2% for 7-day, 1-month, 1-year and lifetime periods, respectively. TSP associated with backpack use varied from 6.0–72.0% and 22.9–51.4% for point and 7-day periods, respectively. TSP interfering with school or leisure ranged from 3.5–9.7% for 1-year prevalence. Generally, studies reported a higher prevalence for TSP in child and adolescent populations, and particularly for females. The 1 month, 6 month, 1 year and 25 year incidences were 0

  2. GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy.

    Science.gov (United States)

    Kuschal, Christiane; Botta, Elena; Orioli, Donata; Digiovanna, John J; Seneca, Sara; Keymolen, Kathelijn; Tamura, Deborah; Heller, Elizabeth; Khan, Sikandar G; Caligiuri, Giuseppina; Lanzafame, Manuela; Nardo, Tiziana; Ricotti, Roberta; Peverali, Fiorenzo A; Stephens, Robert; Zhao, Yongmei; Lehmann, Alan R; Baranello, Laura; Levens, David; Kraemer, Kenneth H; Stefanini, Miria

    2016-04-01

    The general transcription factor IIE (TFIIE) is essential for transcription initiation by RNA polymerase II (RNA pol II) via direct interaction with the basal transcription/DNA repair factor IIH (TFIIH). TFIIH harbors mutations in two rare genetic disorders, the cancer-prone xeroderma pigmentosum (XP) and the cancer-free, multisystem developmental disorder trichothiodystrophy (TTD). The phenotypic complexity resulting from mutations affecting TFIIH has been attributed to the nucleotide excision repair (NER) defect as well as to impaired transcription. Here, we report two unrelated children showing clinical features typical of TTD who harbor different homozygous missense mutations in GTF2E2 (c.448G>C [p.Ala150Pro] and c.559G>T [p.Asp187Tyr]) encoding the beta subunit of transcription factor IIE (TFIIEβ). Repair of ultraviolet-induced DNA damage was normal in the GTF2E2 mutated cells, indicating that TFIIE was not involved in NER. We found decreased protein levels of the two TFIIE subunits (TFIIEα and TFIIEβ) as well as decreased phosphorylation of TFIIEα in cells from both children. Interestingly, decreased phosphorylation of TFIIEα was also seen in TTD cells with mutations in ERCC2, which encodes the XPD subunit of TFIIH, but not in XP cells with ERCC2 mutations. Our findings support the theory that TTD is caused by transcriptional impairments that are distinct from the NER disorder XP.

  3. GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy

    Science.gov (United States)

    Kuschal, Christiane; Botta, Elena; Orioli, Donata; Digiovanna, John J.; Seneca, Sara; Keymolen, Kathelijn; Tamura, Deborah; Heller, Elizabeth; Khan, Sikandar G.; Caligiuri, Giuseppina; Lanzafame, Manuela; Nardo, Tiziana; Ricotti, Roberta; Peverali, Fiorenzo A.; Stephens, Robert; Zhao, Yongmei; Lehmann, Alan R.; Baranello, Laura; Levens, David; Kraemer, Kenneth H.; Stefanini, Miria

    2016-01-01

    The general transcription factor IIE (TFIIE) is essential for transcription initiation by RNA polymerase II (RNA pol II) via direct interaction with the basal transcription/DNA repair factor IIH (TFIIH). TFIIH harbors mutations in two rare genetic disorders, the cancer-prone xeroderma pigmentosum (XP) and the cancer-free, multisystem developmental disorder trichothiodystrophy (TTD). The phenotypic complexity resulting from mutations affecting TFIIH has been attributed to the nucleotide excision repair (NER) defect as well as to impaired transcription. Here, we report two unrelated children showing clinical features typical of TTD who harbor different homozygous missense mutations in GTF2E2 (c.448G>C [p.Ala150Pro] and c.559G>T [p.Asp187Tyr]) encoding the beta subunit of transcription factor IIE (TFIIEβ). Repair of ultraviolet-induced DNA damage was normal in the GTF2E2 mutated cells, indicating that TFIIE was not involved in NER. We found decreased protein levels of the two TFIIE subunits (TFIIEα and TFIIEβ) as well as decreased phosphorylation of TFIIEα in cells from both children. Interestingly, decreased phosphorylation of TFIIEα was also seen in TTD cells with mutations in ERCC2, which encodes the XPD subunit of TFIIH, but not in XP cells with ERCC2 mutations. Our findings support the theory that TTD is caused by transcriptional impairments that are distinct from the NER disorder XP. PMID:26996949

  4. STUDY OF PREMATURE BABIES IN RELATION TO ITS OUTCOME AND ANTENATAL RISK FACTORS AT GENERAL HOSPITAL SANGLI

    Directory of Open Access Journals (Sweden)

    Satish D

    2014-07-01

    Full Text Available : OBJECTIVE: To know the neonatal outcome and antenatal risk factors among premature babies. MATERIAL & METHODS: STUDY DESIGN: A retrospective study. SETTING: Neonatal Intensive Care Unit (NICU of General Hospital Sangli under Government Medical College, Miraj. SAMPLE SIZE: 134 Premature babies admitted during the year 2013 in NICU. DATA COLLECTION: From the case sheet of the study subjects, with the help of pre structured proforma. STUDY PERIOD: January 2013 to December 2013. STATISTICAL ANALYSIS: Data analyzed with percentages. RESULTS: Out of 134 premature babies 34 (25.3% were SGA, 24 (17.9% LGA and 78 (58.2% were AGA. Jaundice (44.7 %, RDS (37.3 % and Sepsis (14.9 % were the commonest morbidities among the premature babies. RDS (85.4%, Sepsis (10.4 % and Aspiration Pneumonia (4.1 % were the causes of mortality. Mortality was higher among premature babies with birth weight < 1400grams. PROM (50.7 %, Anemia (35.8 % and Twin (17.9 % were the maternal risk factors. CONCLUSION: Jaundice, RDS and Sepsis were the common morbidities among the premature babies. Overall mortality among premature babies was 35.8 %. PROM and Anemia are the commonest maternal risk factors for the premature births.

  5. Weight lifting can facilitate appreciative comprehension for museum exhibits

    Directory of Open Access Journals (Sweden)

    Yuki eYamada

    2014-04-01

    Full Text Available Appreciation of exhibits in a museum can be equated to a virtual experience of lives in the contexts originally surrounding the exhibits. Here we focus on the importance of weight information, and hence tested whether experiencing a weight during museum exhibit appreciation affects the beholders’ satisfaction and recognition memory for the exhibits. An experiment was performed at a museum exhibiting skeletal preparations of animals. We used nine preparations and prepared four weight stimuli as weight cues in accordance with the actual weight of four of the preparations: Remaining five preparations was displayed without weight stimuli. In the cued condition, participants were asked to lift up the weight stimuli during their observation of the four exhibits. In the uncued condition, participants observed the exhibits without touching the weight stimuli. After observation of the exhibits, the participants responded to a questionnaire that measured their impressions of the exhibits and the museum, and performed a recognition test on the exhibits. Results showed that memory performance was better and viewing duration was longer with weight lifting instruction than without instruction. A factor analysis on the questionnaires revealed four factors (likeability, contentment, value, and quality. A path analysis showed indirect effects of viewing duration on memory performance and willingness-to-pay for the museum appreciation through the impression factors. Our findings provide insight into a new interactive exhibition that enables long appreciation producing positive effects on visitors’ impression, memory, and value estimation for exhibits.

  6. Green Revolution for Exhibition Industry

    Institute of Scientific and Technical Information of China (English)

    Yan Manman

    2010-01-01

    @@ Shanghai World Expo is widely regarded as another grand international pageant, so many people thought that the opening ceremony must be as much magnificent and brilliant as the opening ceremony for Beijing Olympics.However, it was revealed by Wan Jifei, Executive Director of the ExecutiveCommittee of the Shanghai World Expo that the opening ceremony of the Expo was not that luxurious and extravagant as that for the Beijing Olympics, but would have its own characteristics under the elaborate design and thorough arrangement conducted by the host. The veto against that luxurious opening ceremony was actually a practice echoing for the concept of Green World Expo, which would be applied for every corner from the beginning to the end of the Expo, including the construction of exhibition hall, building of exhibition stand and advertisement etc.

  7. World Expo and Exhibition Industry

    Institute of Scientific and Technical Information of China (English)

    Guo Liqin

    2010-01-01

    @@ February 8 witnessed the construction of 2010 World Expo's China Pavilion completed after two years' work. The pavilion, in the shape of an oriental crown,showcases the spirit of traditional Chinese culture. It is significant since all other nation's pavilion constructed only for temporary exhibition, but China's Pavilion will be lasting architecture as the symbol of world civilization. Another similar famous case is Eiffel Tower which was built as the entrance of the world expo held in. 1889.

  8. A New Exhibition in Microcosm

    CERN Multimedia

    2000-01-01

    Sebastien Pelletier explains states of matter to an enthusiastic group of youngsters during the opening of a new exhibition in Microcosm last week. The Fun with Physics workshop will be offered to all 13-14 year olds in school groups visiting CERN this year. The new Microcosm contents have been developed in collaboration with the local teaching community, and cover particles and the forces that act between them.

  9. Mobile Technologies in Museum Exhibitions

    Directory of Open Access Journals (Sweden)

    Sandra Medić

    2014-10-01

    Full Text Available In order to be up–to–date and give visitors a memorable and unique experience, museums are including usage of digital technologies in their exhibitions. Even though museums in Serbia are very important part of tourism offer, they still have traditional settings that are poorly interpreted. The majority of them have a scientific and historical review which is unattractive for various target groups of visitors and for museums it’s important to continually try out new ways in interpretation of their settings. Because technology continues to rapidly change the way we communicate, cultural institutions should adapt to new ways of communication with their visitors. This paper examines mobile technologies that can be used in museums to give visitors a different experience and transfer the knowledge innovatively. In that way it will be presented the modern concept of presentation of museum exhibitions, focusing on usage of mobile devices through mobile applications and QR codes. The paper provides the broad understanding of usage mobile technologies in museum exhibitions with its advantages and limitations. The research results can help the museums management to improve interpretation and communication with visitors and enrich the visitor experience.

  10. General continuous-time Markov model of sequence evolution via insertions/deletions: are alignment probabilities factorable?

    Science.gov (United States)

    Ezawa, Kiyoshi

    2016-08-11

    Insertions and deletions (indels) account for more nucleotide differences between two related DNA sequences than substitutions do, and thus it is imperative to develop a stochastic evolutionary model that enables us to reliably calculate the probability of the sequence evolution through indel processes. Recently, indel probabilistic models are mostly based on either hidden Markov models (HMMs) or transducer theories, both of which give the indel component of the probability of a given sequence alignment as a product of either probabilities of column-to-column transitions or block-wise contributions along the alignment. However, it is not a priori clear how these models are related with any genuine stochastic evolutionary model, which describes the stochastic evolution of an entire sequence along the time-axis. Moreover, currently none of these models can fully accommodate biologically realistic features, such as overlapping indels, power-law indel-length distributions, and indel rate variation across regions. Here, we theoretically dissect the ab initio calculation of the probability of a given sequence alignment under a genuine stochastic evolutionary model, more specifically, a general continuous-time Markov model of the evolution of an entire sequence via insertions and deletions. Our model is a simple extension of the general "substitution/insertion/deletion (SID) model". Using the operator representation of indels and the technique of time-dependent perturbation theory, we express the ab initio probability as a summation over all alignment-consistent indel histories. Exploiting the equivalence relations between different indel histories, we find a "sufficient and nearly necessary" set of conditions under which the probability can be factorized into the product of an overall factor and the contributions from regions separated by gapless columns of the alignment, thus providing a sort of generalized HMM. The conditions distinguish evolutionary models with

  11. A two-component system, an anti-sigma factor and two paralogous ECF sigma factors are involved in the control of general stress response in Caulobacter crescentus.

    Science.gov (United States)

    Lourenço, Rogério F; Kohler, Christian; Gomes, Suely L

    2011-06-01

    The extracytoplasmic function sigma factor σ(T) is the master regulator of general stress response in Caulobacter crescentus and controls the expression of its paralogue σ(U). In this work we showed that PhyR and NepR act, respectively, as positive and negative regulators of σ(T) expression and function. Biochemical data also demonstrated that NepR directly binds σ(T) and the phosphorylated form of PhyR. We also described the essential role of the histidine kinase gene CC3474, here denominated phyK, for expression of σ(T)-dependent genes and for resistance to stress conditions. Additionally, in vivo evidence of PhyK-dependent phosphorylation of PhyR is presented. This study also identified a conserved cysteine residue (C95) located in the periplasmic portion of PhyK that is crucial for the function of the protein. Furthermore, we showed that PhyK, PhyR and σ(T) regulate the same set of genes and that σ(T) apparently directly controls most of its regulon. In contrast, σ(U) seems to have a very modest contribution to the expression of a subset of σ(T)-dependent genes. In conclusion, this report describes the molecular mechanism involved in the control of general stress response in C. crescentus.

  12. Active Cyber Defense Dynamics Exhibiting Rich Phenomena

    CERN Document Server

    Zheng, Ren; Xu, Shouhuai

    2016-01-01

    The Internet is a man-made complex system under constant attacks (e.g., Advanced Persistent Threats and malwares). It is therefore important to understand the phenomena that can be induced by the interaction between cyber attacks and cyber defenses. In this paper, we explore the rich phenomena that can be exhibited when the defender employs active defense to combat cyber attacks. To the best of our knowledge, this is the first study that shows that {\\em active cyber defense dynamics} (or more generally, {\\em cybersecurity dynamics}) can exhibit the bifurcation and chaos phenomena. This has profound implications for cyber security measurement and prediction: (i) it is infeasible (or even impossible) to accurately measure and predict cyber security under certain circumstances; (ii) the defender must manipulate the dynamics to avoid such {\\em unmanageable situations} in real-life defense operations.

  13. The factor structure of the twelve item General Health Questionnaire (GHQ-12: the result of negative phrasing?

    Directory of Open Access Journals (Sweden)

    Hankins Matthew

    2008-04-01

    Full Text Available Abstract Background The 12-item General Health Questionnaire (GHQ-12 is used routinely as a unidimensional measure of psychological morbidity. Many factor-analytic studies have reported that the GHQ-12 has two or three dimensions, threatening its validity. It is possible that these 'dimensions' are the result of the wording of the GHQ-12, namely its division into positively phrased (PP and negatively phrased (NP statements about mood states. Such 'method effects' introduce response bias which should be taken into account when deriving and interpreting factors. Methods GHQ-12 data were obtained from the 2004 cohort of the Health Survey for England (N = 3705. Following exploratory factor analysis (EFA, the goodness of fit indices of one, two and three factor models were compared with those of a unidimensional model specifying response bias on the NP items, using structural equation modelling (SEM. The hypotheses were (1 the variance of the responses would be significantly higher for NP items than for PP items because of response bias, and (2 that the modelling of response bias would provide the best fit for the data. Results Consistent with previous reports, EFA suggested a two-factor solution dividing the items into NP and PP items. The variance of responses to the NP items was substantially and significantly higher than for the PP items. The model incorporating response bias was the best fit for the data on all indices (RMSEA = 0.068, 90%CL = 0.064, 0.073. Analysis of the frequency of responses suggests that the response bias derives from the ambiguity of the response options for the absence of negative mood states. Conclusion The data are consistent with the GHQ-12 being a unidimensional scale with a substantial degree of response bias for the negatively phrased items. Studies that report the GHQ-12 as multidimensional without taking this response bias into account risk interpreting the artefactual factor structure as denoting 'real' constructs

  14. Association between the Five Factor personality traits and perceived stress: is the effect mediated by general self-efficacy?

    DEFF Research Database (Denmark)

    Ebstrup, Jeanette Frost; Eplov, Lene Falgaard; Pisinger, Charlotta

    2011-01-01

    of neuroticism, extroversion, openness, agreeableness, and conscientiousness, and to explore the role of general self-efficacy (GSE). A population-based cross-sectional study was conducted at the Research Centre for Prevention and Health, Denmark, in 2006-2008. Men and women (N=3471) aged 18-69, were randomly......-significant - whilst neuroticism had a positive association. The associations with agreeableness and openness became positive and significant, respectively, when GSE was included. All five personality-stress models were mediated by GSE, with extroversion and conscientiousness having the strongest mediating effect....... The strongest stress-association was found for neuroticism. GSE was shown to change the impact and interpretation of the personality dimensions on perceived stress. These results indicate that GSE is an important factor to consider in the link between personality and perceived stress....

  15. Isolation and characterization of csbB, a gene controlled by Bacillus subtilis general stress transcription factor sigma B.

    Science.gov (United States)

    Akbar, S; Price, C W

    1996-10-24

    In the bacterium Bacillus subtilis (Bs), the alternative transcription factor sigma B is activated by environmental stresses to control the expression of a large set of unlinked genes. However, the range of physiological functions mediated by these sigma B-controlled genes is presently unknown. We report here that the newly identified gene csbB is under the dual control of a sigma B-dependent and a sigma B-independent promoter. The predicted product of csbB is a 329 residue protein containing two potential membrane-spanning segments in its C-terminal region, leading us to speculate that one class of sigma B-controlled genes acts to modify the cell envelope as part of the general stress response.

  16. No evidence that social desirability response set explains the general factor of personality and its affective correlates.

    Science.gov (United States)

    Rushton, J Philippe; Erdle, Stephen

    2010-04-01

    In two studies, the General Factor of Personality (GFP) remained intact after controlling for the Lie scale from the Eysenck Personality Questionnaire, despite the Lie Scale showing significant correlations with the GFP defining traits. In Study 1, a re-analysis of 29 self-ratings from 322 pairs of twins (644 individuals) yielded a GFP both before and after controlling for social desirability. In Study 2, four measures of affect in 133 university students loaded on a GFP both before and after controlling for social desirability such that those high on the GFP were high in self-esteem and positive affect and low in depression and negative affect. These results join those from other studies failing to find evidence that the GFP is merely an artifact of evaluative bias.

  17. The Factor Relate to Job Performance of Nurse with Health Nursing Documentation at Paniai General Hospital Papuan Province

    Directory of Open Access Journals (Sweden)

    Pebur Mote

    2016-12-01

    Full Text Available Nurse as tip of spear in health care at Hospital, having task gives upbringing in to care. Upbringing documentation to care as medium of communication, accountability and takes on sue, statistical information, education medium, observational data source, ministering quality surety, planning data source upbringing to extended care. Data documents helat nursing at Paniai General Hospital upbringing was maximal being done. The goal of this research is to know the regard factor job performance of nurse with health nursing documentation at paniai general hospital. Observational method : This observational type is descriptive analytic with approaching crossectional study. Research is done on month of September- October 2016 at Paniai general hospital. Population is overall nurse at spatial nursed Paniaigeneral hospital as much 81 person consisting of room HCU as much 14 person, room dissects 18 person, coherent room 17 person, mature room 18 person and spatial childs 13 person. The result of this research shwes that there is corelations among nurse age(ρ-value = 0,927; RP = 0,937; CI95%= 0,937; 0,667 – 1,316, gender(ρ -value = 0,933; RP = 1,058; CI95%= 0,768 – 1,457, education (ρ -value = 0,092; RP = 2,080; CI95%= 0,664 – 6,514, working life(ρ -value = 0,927, RP = 0,927; CI95%= 0,667 – 1,316 and nurse science(ρ-value = 0,125, RP= 1,367; CI95%= 1,031 – 1,814 to helath nursing documentation at Paniai General Hospital. Meanwhile there is no corelation among nurse attitude(ρ -value = 0,002; RP = 1,711; CI95%= 1,206 – 2,426, nurse motivation(ρ -value = 0,047, RP = 1,447; CI95%= 1,015 – 2,062, supervision to nurse care(ρ -value = 0,024; RP = 1,484; CI95%= 1,123 – 1,960 and reward (ρ-value= 0,002; RP = 1,855; CI95%= 1,206 – 2,855 to helath nursing documentation at Paniai General Hospital.

  18. Factors associated with and consequences of unplanned post-operative intubation in elderly vascular and general surgery patients.

    Science.gov (United States)

    Nafiu, Olubukola O; Ramachandran, Satya K; Ackwerh, Ray; Tremper, Kevin K; Campbell, Darrell A; Stanley, James C

    2011-03-01

    Unplanned post-operative intubation (UPI) may be associated with significant morbidity and/or mortality after surgery. The purpose of this investigation was to determine the incidence and predictors of UPI in elderly patients who underwent general and vascular surgical procedures. Data from the American College of Surgeons National Surgical Quality Improvement Program Participant Use Data File was used to calculate the incidence of UPI in all elderly vascular and general surgery patients undergoing operations from 2005 to 2008. UPI was defined as a requirement for the placement of an endotracheal tube and mechanical or assisted ventilation because of the onset of respiratory or cardiac failure manifested by severe respiratory distress, hypoxia, hypercarbia or respiratory acidosis within 30 days of the index operation. Univariate factors associated with UPI were identified. Multivariate stepwise logistic regression was used to calculate odds ratios (ORs) for UPI after controlling for known clinically relevant cofactors. Incidence of UPI as well as morbidity and mortality associated with UPI. Among 115 692 patients, 3.3% required UPI. Univariate predictors of UPI were older age group, chronic obstructive pulmonary disease, low pre-operative functional status as well as emergency operation. UPI was associated with an 18-fold increased risk of death as well as significantly increased hospital length of stay. Multivariate analysis identified several predictors of UPI with re-operation having the greatest odds for UPI (OR = 4.5; 95% confidence interval = 4.29-4.86, P < 0.001). Although the incidence of UPI in this elderly surgical cohort was low, it was associated with significant morbidity and mortality as well as prolonged hospital length of stay, underscoring the need for accurately identifying modifiable risk factors.

  19. Risk factors associated with calcium oxalate urolithiasis in dogs evaluated at general care veterinary hospitals in the United States.

    Science.gov (United States)

    Okafor, Chika C; Lefebvre, Sandra L; Pearl, David L; Yang, Mingyin; Wang, Mansen; Blois, Shauna L; Lund, Elizabeth M; Dewey, Cate E

    2014-08-01

    Calcium oxalate urolithiasis results from the formation of aggregates of calcium salts in the urinary tract. Difficulties associated with effectively treating calcium oxalate urolithiasis and the proportional increase in the prevalence of calcium oxalate uroliths relative to other urolith types over the last 2 decades has increased the concern of clinicians about this disease. To determine factors associated with the development of calcium oxalate urolithiasis in dogs evaluated at general care veterinary hospitals in the United States, a retrospective case-control study was performed. A national electronic database of medical records of all dogs evaluated between October 1, 2007 and December 31, 2010 at 787 general care veterinary hospitals in the United States was reviewed. Dogs were selected as cases at the first-time diagnosis of a laboratory-confirmed urolith comprised of at least 70% calcium oxalate (n=452). Two sets of control dogs with no history of urolithiasis diagnosis were randomly selected after the medical records of all remaining dogs were reviewed: urinalysis examination was a requirement in the selection of one set (n=1808) but was not required in the other set (n=1808). Historical information extracted included urolith composition, dog's diet, age, sex, neuter status, breed size category, hospital location, date of diagnosis, and urinalysis results. Multivariable analysis showed that the odds of first-time diagnosis of calcium oxalate urolithiasis were significantly (P30 mg/dL (OR: 1.55, 1.04-2.30). Patient demographics and urinalysis results are important factors that can support risk assessment and early identification of canine oxalate urolithiasis. Therefore, periodic urolith screening and monitoring of urine parameters should be encouraged for dogs at risk of developing these uroliths.

  20. Epidemiological factors associated with ESBL- and non ESBL-producing E. coli causing urinary tract infection in general practice.

    Science.gov (United States)

    Hertz, Frederik Boëtius; Schønning, Kristian; Rasmussen, Steen Christian; Littauer, Pia; Knudsen, Jenny Dahl; Løbner-Olesen, Anders; Frimodt-Møller, Niels

    2016-01-01

    The purpose of the study was to evaluate how use of antibiotics precedes the presence of ESBL-producing E.coli in general practice. The authors performed a triple-case-control study where three case groups were individually compared to a single control group of uninfected individuals. Urine samples were prospectively collected and retrospective statistical analyses were done. This study included 98 cases with urinary tract infection (UTI) caused by ESBL-producing E. coli, 174 with antibiotic-resistant (non-ESBL) E. coli, 177 with susceptible E. coli and 200 with culture negative urine samples. Case groups had significantly higher use of antibiotics than the control group within 30 days before infection (p ESBL group had significantly more hospital admissions than the other case groups (p ESBL-producing E. coli. Exposure to antibiotics was a risk factor for UTI with E. coli, while prior antibiotic usage was not an indisputable predictor for infection with ESBL-producing E.coli in general practice.

  1. HBV X PROTEIN (HBX) INTERACTS WITH GENERAL TRANSCRIPTION FACTOR TFIIB BOTH IN VITRO AND IN VIVO

    Institute of Scientific and Technical Information of China (English)

    杨益大; 马亦林; 郑临; 陈亚岗; 马伟杭; 村上清史

    1999-01-01

    Objective. In order to demonstrate the binding ot HBV X protein (HBX) with the general transcription factor TFIIB. Methods. In vitro glutathion S-transferase (GST) resin Pull Down assay and Far-Western Blotting assay, in vivo Co-immunoprecipition assay were used. Results. The X199 (51-99) domain of HBX is reponsibIe for HBX binding to TFIIB. While the dl0 domain (J25-295) of TFIIB is required tor TFIIB binding to HBX. When the two basic amino acids (K) at position 178 and 189 of TFIIB were substituted by neutral amino acids (L), the binding of TFIIBKI78L and KI89L to HBX was siginificantly reduced. When the the basic amino acids were substituted by the acidic amino acids (E), the binding of TFIIB K178E and K189E to HBX were almost lost. In vitro results of HBX binding to TFIIB were further confirmed by in vivo co-immunoprecipitation assay. Our results also indicated that the Woodchuck.hepatitis virus X protein (WHX) interacts with TFIIB. Canclusion. These results suggested that the communication between HBX and general transcription tactor TFIIR is crae of the mechanisms which account for its transeriptional transactivation.

  2. General and abdominal adiposity in a representative sample of Portuguese adults: dependency of measures and socio-demographic factors' influence.

    Science.gov (United States)

    Kowalkowska, Joanna; Poínhos, Rui; Franchini, Bela; Afonso, Cláudia; Correia, Flora; Pinhão, Sílvia; Vaz de Almeida, Maria Daniel; Rodrigues, Sara

    2016-01-14

    The aims of this study were: (i) to estimate the dependency between BMI and waist:height ratio (WHtR) as measures of general and abdominal adiposity, and (ii) to evaluate the influence of socio-demographic factors on both measures and on their dependency in risk classification. Data from a cross-sectional study conducted in 2009 among a representative sample of 3529 Portuguese adults were used. Height, weight and waist were measured and socio-demographic data (sex, age, education level, occupational status, marital status, region of residence) were obtained. Using logistic regression, crude and adjusted OR for high general (BMI≥25·0 kg/m²) and abdominal (WHtR≥0·5) adiposity, and for incompatible classification between them, were calculated. Above half (50·8%) of the respondents had high BMI and 42·1% had high WHtR, and the rates were higher in men than in women. There was an inverse association between education level and both adiposity measures. The lowest prevalence of high general and abdominal adiposity was observed in students and singles, whereas the highest was found in retired, widowed and respondents from Azores, Madeira and Alentejo. Nearly a quarter of respondents (24·0%) were incompatibly classified by BMI and WHtR, with higher prevalence in men than in women and in low- than in high-educated people. Future surveys should focus on developing at least sex-specific cut-offs for both measures. Implementation of effective strategies for preventing and reducing high adiposity levels in Portugal should be directed primarily to men, older, low-educated individuals, as well as those living in the islands and poor regions of the country.

  3. Borneo 2007. Three European Exhibitions

    Directory of Open Access Journals (Sweden)

    Bernard Sellato

    2013-01-01

    Full Text Available The year 2007 appears to have been an exceptionally good one for Borneo in Europe. Two exhibitions were held in France, and one in Switzerland, which prominently featured the big island, its forests, its peoples, its cultures, and its arts. Here a brief review of these three events. Bornéo... Dayak et Punan. Peuples de la forêt tropicale humide, Musée d’Art et d’Archéologie, Laon, France, 25 November 2006 – 11 March 2007 The beautiful city of Laon, only a short distance by train or by car fro...

  4. CERN Permanent exhibitions short version

    CERN Multimedia

    2016-01-01

    Visits Explore by yourself the issues CERN's physicists are trying to solve: given that the entire universe is made of particles, where do they come from? Why do they behave in the way they do? Discover the massive apparatus used by physicists at CERN, like the LHC, and see how each part works. CERN invites the public to discover the mysteries of the Universe and the work of the world's biggest physics laboratory through free of charge guided tours and permanent exhibitions. As a group, with friends, individually, on foot, on your bike, come and discover CERN or explore it virtually. Welcome!

  5. Generation of Leukemia Inhibitory Factor-Dependent Induced Pluripotent Stem Cells from the Massachusetts General Hospital Miniature Pig

    Directory of Open Access Journals (Sweden)

    Dae-Jin Kwon

    2013-01-01

    Full Text Available The generation and application of porcine induced pluripotent stem cells (iPSCs may enable the testing for safety and efficacy of therapy in the field of human regenerative medicine. Here, the generation of iPSCs from the Massachusetts General Hospital miniature pig (MGH minipig established for organ transplantation studies is reported. Fibroblasts were isolated from the skin of the ear of a 10-day-old MGH minipig and transduced with a cocktail of six human factors: POU5F1, NANOG, SOX2, C-MYC, KLF4, and LIN28. Two distinct types of iPSCs were generated that were positive for alkaline phosphatase activity, as well as the classical pluripotency markers: Oct4, Nanog, Sox2, and the surface marker Ssea-1. Only one of two porcine iPSC lines differentiated into three germ layers both in vitro and in vivo. Western blot analysis showed that the porcine iPSCs were dependent on LIF or BMP-4 to sustain self-renewal and pluripotency. In conclusion, the results showed that human pluripotent factors could reprogram porcine ear fibroblasts into the pluripotent state. These cells may provide a useful source of cells that could be used for the treatment of degenerative and genetic diseases and agricultural research and application.

  6. Which factors influence onset and latency to treatment in generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder?

    Science.gov (United States)

    Benatti, Beatrice; Camuri, Giulia; Dell'Osso, Bernardo; Cremaschi, Laura; Sembira, Ester; Palazzo, Carlotta; Oldani, Lucio; Dobrea, Cristina; Arici, Chiara; Primavera, Diego; Carpiniello, Bernardo; Castellano, Filippo; Carrà, Giuseppe; Clerici, Massimo; Baldwin, David S; Altamura, Alfredo Carlo

    2016-11-01

    Anxiety disorders are common, comorbid, and disabling conditions, often underdiagnosed and under-treated, typically with an early onset, chronic course, and prolonged duration of untreated illness. The present study aimed to explore the influence of sociodemographic and clinical factors in relation to onset and latency to treatment in patients with generalized anxiety disorder (GAD), panic disorder (PD), and obsessive-compulsive disorder (OCD). A total of 157 patients with a Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Text Revision (DSM-IV-TR) diagnosis of PD (n=49), GAD (n=68), and OCD (n=40) were recruited, and epidemiological and clinical variables were collected through a specific questionnaire. Statistical analyses were carried out to compare variables across diagnostic groups. PD, GAD, and OCD patients showed a duration of untreated illness of 53.9±81.5, 77.47±95.76, and 90.6±112.1 months, respectively. Significant differences between groups were found with respect to age, age of first diagnosis, age of first treatment, family history of psychiatric illness, onset-related stressful events, benzodiazepine prescription as first treatment, antidepressant prescription as first treatment, and help-seeking (self-initiated vs. initiated by others). Patients with GAD, PD, and OCD showed significant differences in factors influencing onset and latency to treatment, which may, in turn, affect condition-related outcome and overall prognosis. Further studies with larger samples are warranted in the field.

  7. Incidence and risk factors for unplanned transfers to acute general hospitals from an intermediate care and rehabilitation geriatric facility.

    Science.gov (United States)

    Colprim, Daniel; Inzitari, Marco

    2014-09-01

    Unplanned acute hospital transfers (AT) from post-acute or long-term care facilities represent critical transitions, which expose patients to negative health outcomes and increase the burden of the emergency departments that receive these patients. We aim at determining incidence and risk factors for AT during the first 30 days of admission at an intermediate care and rehabilitation geriatric facility (ICGF). Prospective cohort study conducted in an ICGF of Barcelona, Spain. Sociodemographics, main diagnostics, and variables of the comprehensive geriatric assessment were recorded at admission. At the moment of AT, suspected diagnostic motivating the transfer was recorded. Multivariable Cox proportional hazard models were used to evaluate the association between admission characteristics and AT. We included 1505 patients (mean age + standard deviation = 81.31 ± 7.06, 65.7% women). AT were 217 (14.4%, 5.64/1000 days of stay) resulting in only 81 final hospitalizations (37% of AT), whereas 136 patients returned to ICGF after visiting the emergency department. Principal triggers of AT were cardiovascular, falls/orthopedic, and gastrointestinal problems. Being admitted to ICGF after a general surgery [hazard ratio (HR) 1.88; 95% confidence interval (CI) 1.21-2.94; P hospital, suggesting perhaps some avoidable AT. Identification of risk factors might be relevant to design strategies to reduce AT. Copyright © 2014 AMDA – The Society for Post-Acute and Long-Term Care Medicine. Published by Elsevier Inc. All rights reserved.

  8. A modified operational sequence methodology for zoo exhibit design and renovation: conceptualizing animals, staff, and visitors as interdependent coworkers.

    Science.gov (United States)

    Kelling, Nicholas J; Gaalema, Diann E; Kelling, Angela S

    2014-01-01

    Human factors analyses have been used to improve efficiency and safety in various work environments. Although generally limited to humans, the universality of these analyses allows for their formal application to a much broader domain. This paper outlines a model for the use of human factors to enhance zoo exhibits and optimize spaces for all user groups; zoo animals, zoo visitors, and zoo staff members. Zoo exhibits are multi-faceted and each user group has a distinct set of requirements that can clash or complement each other. Careful analysis and a reframing of the three groups as interdependent coworkers can enhance safety, efficiency, and experience for all user groups. This paper details a general creation and specific examples of the use of the modified human factors tools of function allocation, operational sequence diagram and needs assessment. These tools allow for adaptability and ease of understanding in the design or renovation of exhibits.

  9. An examination of the relationship between personality and aggression using the general aggression and five factor models.

    Science.gov (United States)

    Hosie, Julia; Gilbert, Flora; Simpson, Katrina; Daffern, Michael

    2014-01-01

    This study examined the relationships between personality and aggression using the general aggression (GAM, Anderson and Bushman [2002] Annual Review of Psychology, 53, 27-51) and five factor models (FFMs) (Costa and McCrae [1992] Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) professional manual. Odessa, FL: Psychological Assessment Resources). Specifically, it examined Ferguson and Dyck's (Ferguson and Dyck [2012] Aggression and Violent Behavior, 17, 220-228) criticisms that the GAM has questionable validity in clinical populations and disproportionately focuses on aggression-related knowledge structures to the detriment of other inputs, specifically personality variables. Fifty-five male offenders attending a community forensic mental health service for pre-sentence psychiatric and/or psychological evaluation were assessed for aggressive script rehearsal, aggression-supportive normative beliefs, FFM personality traits, trait anger and past aggressive behavior. With regard to relationships between five factor variables and aggression, results suggested that only agreeableness and conscientiousness were related to aggression. However, these relationships were: (1) weak in comparison with those between script rehearsal, normative beliefs and trait anger with aggression and (2) were not significant predictors in hierarchical regression analysis when all of the significant univariate predictors, including GAM-specified variables were regressed onto life history of aggression; normative beliefs supporting aggression, aggressive script rehearsal, and trait anger were significantly related to aggression in this regression analysis. These results provide further support for the application of the GAM to aggressive populations. © 2013 Wiley Periodicals, Inc.

  10. Psychosocial factors at work and sleep problems: a longitudinal study of the general working population in Norway.

    Science.gov (United States)

    Johannessen, Håkon A; Sterud, Tom

    2017-04-20

    A growing number of longitudinal studies report associations between adverse psychosocial factors at work and sleep problems. However, the evidence regarding the direction of these associations and the effects of changes in exposure across time is limited. This study examined the plausibility of normal, reverse, and reciprocal associations between ten psychosocial factors at work and sleep problems. In addition, we analyzed if reduced exposure across time had the anticipated result of reducing the risk of sleep problems. Randomly drawn from the general working-age population, the cohort comprised respondents with an active employee relationship in 2009 and 2013 (N = 5760). Exposures and outcome were measured on two occasions separated by 4 years. We computed several sex-stratified logistic regression models with adjustments for various plausible confounders. We found support for the commonly hypothesized unidirectional forward associations between psychosocial factors at work and sleep problems among women only. Among men, psychosocial stressors at work and sleep problems were reciprocally and reversely related. Nevertheless, reduced exposure levels across time pertaining to effort-reward imbalance (OR = 0.36; 95% CI = 0.19-0.69) and lack of social support (OR = 0.55; 95% CI = 0.32-0.93) among men, and work-family imbalance (OR = 0.26; 95% CI = 0.15-0.46) among women were associated with a robust significant lower risk of sleep problems compared to those in the stable high exposure groups. The study results suggest that preventive measures targeting effort-reward imbalance and lack of social support among men, and work-family imbalance among women, might contribute to reduce the risk of troubled sleep among employees.

  11. Nonadherence and factors affecting adherence of diabetic patients to anti-diabetic medication in Assela General Hospital, Oromia Region, Ethiopia

    Directory of Open Access Journals (Sweden)

    Ashebir Kassahun

    2016-01-01

    Full Text Available Background: Diabetes mellitus is a major global health problem covering approximately 347 million persons worldwide. Glycemic control has a main role in its management which mainly depends upon patient adherence to the treatment plan. Accurate assessment of medication adherence is necessary for effective management of diabetes. Objective: To assess nonadherence and factors affecting adherence of diabetic patients to anti-diabetic medication in Assela General Hospital (AGH, Oromia Region, Ethiopia. Materials and Methods: A descriptive cross-sectional study was conducted on patients seeking anti-diabetic drug treatment and follow-up at AGH using structured questionnaire and reviewing the patient record card using check list from January 24, 2014 to February 7, 2014. Descriptive analysis was used to describe the percentages and number of distributions of the variables in the study; and association was identified for categorical data. P ≤ 0.05 was considered as statistically significant. Result: Of all respondents, 149 (52.3% and 136 (47.7% were female and male, respectively. The majority of the study participants 189 (66.3% were in the age group of 30–60 years. Two-hundred nineteen (76.8% of respondents were married currently. The majority, 237 (83.2% of respondents did not have blood glucose self-monitoring equipment (glucometer. A total of 196 (68.8% respondents were adhered to anti-diabetic medication. There was a significant association between adherence to the medication and side effect, level of education, monthly income and presence of glucometer at home (P < 0.05. Conclusion: The participants in the area of study were moderately adherent to their anti-diabetic medications with nonadherence rate of 31.2%. Different factors of medication nonadherence were identified such as side effect and complexity of regimen, failure to remember, and sociodemographic factors such as educational level and monthly income.

  12. "Britain at CERN" exhibition, from 14 to 17 November 2000

    CERN Multimedia

    Patrice Loïez

    2000-01-01

    H.E. Mr. Christopher Hulse, Ambassador of United Kingdom in Switzerland, CERN Director General Luciano Maiani, Sir David Wright, Chief Executive of British Trade International and Roger Cashmore, CERN Director of research visit the Britain at CERN exhibition

  13. Enrico Fermi exhibition at CERN

    CERN Document Server

    2002-01-01

    A touring exhibition celebrating the centenary of Enrico Fermi's birth in 1901 will be on display at CERN (Main Building, Mezzanine) from 12-27 September. You are cordially invited to the opening celebration on Thursday 12 September at 16:00 (Main Building, Council Chamber), which will include speechs from: Luciano Maiani Welcome and Introduction Arnaldo Stefanini Celebrating Fermi's Centenary in Documents and Pictures Antonino Zichichi The New 'Centro Enrico Fermi' at Via Panisperna Ugo Amaldi Fermi at Via Panisperna and the birth of Nuclear Medicine Jack Steinberger Fermi in Chicago Valentin Telegdi A Close-up of Fermi and the screening of a documentary video about Fermi: Scienziati a Pisa: Enrico Fermi (Scientists at Pisa: Enrico Fermi) created by Francesco Andreotti for La Limonaia from early film, photographs and sound recordings (In Italian, with English subtitles - c. 30 mins). This will be followed by an aperitif on the Mezz...

  14. Enrico Fermi centenary exhibition seminar

    CERN Multimedia

    Maximilien Brice

    2002-01-01

    Photo 01: Dr. Juan Antonio Rubio, Leader of the Education and Technology Transfer Division and CERN Director General, Prof. Luciano Maiani. Photo 03: Luciano Maiani, Welcome and Introduction Photo 09: Antonino Zichichi, The New 'Centro Enrico Fermi' at Via Panisperna Photos 10, 13: Ugo Amaldi, Fermi at Via Panisperna and the birth of Nuclear Medicine Photo 14: Jack Steinberger, Fermi in Chicago Photo 18: Valentin Telegdi, A close-up of Fermi Photo 21: Arnaldo Stefanini, Celebrating Fermi's Centenary in Documents and Pictures.

  15. Acute diarrhea in adults consulting a general practitioner in France during winter: incidence, clinical characteristics, management and risk factors.

    Science.gov (United States)

    Arena, Christophe; Amoros, Jean Pierre; Vaillant, Véronique; Ambert-Balay, Katia; Chikhi-Brachet, Roxane; Jourdan-Da Silva, Nathalie; Varesi, Laurent; Arrighi, Jean; Souty, Cécile; Blanchon, Thierry; Falchi, Alessandra; Hanslik, Thomas

    2014-10-30

    Data describing the epidemiology and management of viral acute diarrhea (AD) in adults are scant. The objective of this study was to identify the incidence, clinical characteristics, management and risk factors of winter viral AD in adults. The incidence of AD in adults during two consecutive winters (from December 2010 to April 2011 and from December 2011 to April 2012) was estimated from the French Sentinelles network. During these two winters, a subset of Sentinelles general practitioners (GPs) identified and included adult patients who presented with AD and who filled out a questionnaire and returned a stool specimen for virological examination. All stool specimens were tested for astrovirus, group A rotavirus, human enteric adenovirus, and norovirus of genogroup I and genogroup II. Age- and sex-matched controls were included to permit a case-control analysis with the aim of identifying risk factors for viral AD. During the studied winters, the average incidence of AD in adults was estimated to be 3,158 per 100,000 French adults (95% CI [2,321 - 3,997]). The most reported clinical signs were abdominal pain (91.1%), watery diarrhea (88.5%), and nausea (83.3%). GPs prescribed a treatment in 95% of the patients with AD, and 80% of the working patients with AD could not go to work. Stool examinations were positive for at least one enteric virus in 65% (95% CI [57 - 73]) of patients with AD with a predominance of noroviruses (49%). Having been in contact with a person who has suffered from AD in the last 7 days, whether within or outside the household, and having a job (or being a student) were risk factors significantly associated with acquiring viral AD. During the winter, AD of viral origin is a frequent disease in adults, and noroviruses are most often the cause. No preventable risk factor was identified other than contact with a person with AD. Thus, at the present time, reinforcement of education related to hand hygiene remains the only way to reduce the

  16. 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia: summary of main findings and risk factors.

    Science.gov (United States)

    Pandit, J J; Andrade, J; Bogod, D G; Hitchman, J M; Jonker, W R; Lucas, N; Mackay, J H; Nimmo, A F; O'Connor, K; O'Sullivan, E P; Paul, R G; Palmer, J H M G; Plaat, F; Radcliffe, J J; Sury, M R J; Torevell, H E; Wang, M; Hainsworth, J; Cook, T M

    2014-10-01

    We present the main findings of the 5th National Audit Project (NAP5) on accidental awareness during general anaesthesia (AAGA). Incidences were estimated using reports of accidental awareness as the numerator, and a parallel national anaesthetic activity survey to provide denominator data. The incidence of certain/probable and possible accidental awareness cases was ~1:19,600 anaesthetics (95% confidence interval 1:16,700-23,450). However, there was considerable variation across subtypes of techniques or subspecialities. The incidence with neuromuscular block (NMB) was ~1:8200 (1:7030-9700), and without, it was ~1:135,900 (1:78,600-299,000). The cases of AAGA reported to NAP5 were overwhelmingly cases of unintended awareness during NMB. The incidence of accidental awareness during Caesarean section was ~1:670 (1:380-1300). Two-thirds (82, 66%) of cases of accidental awareness experiences arose in the dynamic phases of anaesthesia, namely induction of and emergence from anaesthesia. During induction of anaesthesia, contributory factors included: use of thiopental, rapid sequence induction, obesity, difficult airway management, NMB, and interruptions of anaesthetic delivery during movement from anaesthetic room to theatre. During emergence from anaesthesia, residual paralysis was perceived by patients as accidental awareness, and commonly related to a failure to ensure full return of motor capacity. One-third (43, 33%) of accidental awareness events arose during the maintenance phase of anaesthesia, mostly due to problems at induction or towards the end of anaesthesia. Factors increasing the risk of accidental awareness included: female sex, age (younger adults, but not children), obesity, anaesthetist seniority (junior trainees), previous awareness, out-of-hours operating, emergencies, type of surgery (obstetric, cardiac, thoracic), and use of NMB. The following factors were not risk factors for accidental awareness: ASA physical status, race, and use or omission

  17. Quality of life, general health status and related factors in women of polycystic ovary syndrome in Yazd (IRAN 2014

    Directory of Open Access Journals (Sweden)

    Farzaneh Ebrahimi

    2016-07-01

    Full Text Available polycystic ovary syndrome leads to augmentation of behavioral disorders among women and the affects their quality of life. The present study is being carried out in order to assess the quality of life and the level of general health in women suffering polycystic ovary syndrome in Baghayipour Treatment Center customers in the city of Yazd in IRAN 2013-14 and its relevant factors. This descriptive-analytical study has been done in a cross-sectional method during nine months on seventy three women who were suffering polycystic ovary syndrome through convenience sampling technique. For data collection PCOSQ and GHQ-28 surveys are used. Factors to enter the study involve the age range of 15-49, affliction with PCO, satisfaction of taking part in a study and the factors for leaving it including being affected with galactorrhoea (i.e. automatic lactation from breasts, thyroid problems, Cushing syndrome or the consumers of corticosteroid drugs. The data were analyzed by means of SPSS software and the descriptive statistics tests and regression. The results of descriptive statistics tests indicated that the average age of 26.28± 5.59 years, body mass index (BMI of 28.09 ± 5.06, %5.5 of the participants are illiterate, %17.8 of them are people with less than high school diploma, %24.7 have high school diploma degree, and %52.1 of them have university degrees. The average score for the quality of life among women was 111.36 ± 21.39 as well. The greatest factor influencing the quality of life according to the achieved score in these patients were menstruation problems, hirsutism, emotional problems, weight, and finally infertility respectively. By means of regression test there was a meaningful statistical correlation with significance level value of (p<0.05 between the quality of life with BMI, number of pregnancy, intervals between menstruation cycles, and the extent of satisfaction with body image. Polycystic ovary syndrome has a negative impact on

  18. Epidemiology of Suicide and Associated Socio-Demographic Factors in Emergency Department Patients in 7 General Hospitals in Northwestern China.

    Science.gov (United States)

    Zhao, Cheng-jin; Dang, Xing-bo; Su, Xiao-li; Bai, Jia; Ma, Long-yang

    2015-09-15

    This study aimed to illustrate the characteristics of suicide attempters treated in the Emergency Departments of 7 general hospitals in Xi'an and to provide relevant data for early psychological treatment. Between October 2010 and September 2014, 155 suicide attempters were treated in the Emergency Departments. Data were collected using a semi-structured questionnaire. Descriptive statistics, chi-square tests, and multivariate analyses were used to identify the factors associated with suicidal behaviors. Females outnumbered males at a ratio of 3.7 to 1. The greatest proportion of cases was in the age group of 21 to 30 years (52.9%). Patients who finished middle school or high school accounted for most of the suicide attempters (50.3%). The most common method used for attempted suicide was drug ingestion (86.5%). The majority of cases attempted suicide at home (74.8%) during the night. Marriage frustration, work and study problems, family fanaticism and conflict, somatic disease, and history of mental disorders were all significantly associated with suicide attempts. The ratio of patients to be discharged or to die were similar in occupation, marital status, and the place of suicide attempt; however, the results were different in gender, age, educational level, methods used for suicide, time of day, and reason. Suicide is an important public health problem and is multidimensional in nature. Future studies with larger samples are expected to provide more specific knowledge of the effect of each social factor on the suicide risk in Chinese in order to improve the prevention of suicides.

  19. Safety and tolerability of iobitridol in general and in patients with risk factors: Results in more than 160 000 patients

    Energy Technology Data Exchange (ETDEWEB)

    Maurer, Martin, E-mail: martin.maurer@charite.de [Charite - University Medicine Berlin, Department of Radiology, Augustenburger Platz 1, 13353 Berlin (Germany); Heine, Oliver [Guerbet GmbH, Otto-Vogler-Str. 11, 65843 Sulzbach (Germany); Wolf, Michael [Michael Wolf Information Systems, Viktoriastr. 26, 66346 Puettlingen (Germany); Freyhardt, Patrick; Schnapauff, Dirk; Hamm, Bernd [Charite - University Medicine Berlin, Department of Radiology, Augustenburger Platz 1, 13353 Berlin (Germany)

    2011-11-15

    Objective: To review the safety, the tolerability and the diagnostic effectiveness of iobitridol under daily practice conditions in the general population and at-risk patients in a post-marketing surveillance study. Materials and methods: A total of 160 639 patients (55.1% male, 43.6% female, mean age 58.6 years) were analysed in 555 centers. Patients underwent X-ray examinations using iobitridol (Xenetix, Guerbet, Sulzbach, Germany) as IV contrast medium (mean volume 85.6 ml). 21.8% of all patients had at least one risk factor (e.g., renal impairment), 7.3% were at-risk patients with allergies or who had previously reacted to contrast medium. Antiallergic pretreatment before contrast medium administration was given in 1144 patients (0.7%). Adverse events were documented and the image quality was assessed. Results: A diagnosis was possible in 99.5% of all cases. The image quality was rated good or excellent in 92.2%. The adverse event rate (e.g., nausea, urticaria) observed was 0.6% in all patients, 1.6% in patients with allergies and 6.0% in patients with a previous reaction to contrast medium. Adverse events occurred more often in women than in men (p < 0.001). Pretreatment did not decrease the rate of adverse events. The rate of adverse events was not increased in higher doses of iobitridol, even if administered to high-risk patients. Conclusions: Iobitridol was shown to be a safe and well-tolerated contrast medium with a low incidence of adverse events in patients with and without risk factors resulting in a good or excellent image quality in most patients.

  20. EU Climate Change Exhibition Held

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>On April 25, the CPAFFC, the China-EU Association (CEUA) and the Delegation of the European Commission to China jointly held the opening ceremony for the EU Exhibition on Climate Change in the CPAFFC. He Luli, former vice chairperson of the NPC Standing Committee and honorary president of the CEUA, Jose Manuel Barroso, president of the European Commission, and Li Jianping, vice president of the CPAFFC, attended the opening ceremony and made speeches. Honorary President He Luli highly praised the achievements made by China and the EU in their longtime cooperation of mutual benefits in various fields including environmental protection. She said, for many years China and EU have both committed to the development of all-round strategic partnership and establishment of a multi-level mechanism of political dialogue. She expressed, with increasing enthusiasm the CEUA would continue to actively carry out nongovernmental exchanges between China and the EU, and promote cooperation between the two sides in the fields of economy, society, environmental protection, science and technology, culture, etc.

  1. Gender Differences in Lifestyle Factors Associated with Metabolic Syndrome and Preliminary Metabolic Syndrome in the General Population: The Watari Study.

    Science.gov (United States)

    Hattori, Tomomi; Konno, Satoshi; Munakata, Masanori

    2017-09-01

    Objective In Japan, metabolic syndrome (MetS) and preliminary metabolic syndrome (preMetS) are more prevalent in men; however, it remains unclear whether the relationship between these metabolic disorders and lifestyle factors is similar between genders. Methods We examined waist circumference, blood pressure, fasting blood, and various lifestyle factors in 3,166 individuals aged from 30-79 years of age from the Japanese general population. MetS was diagnosed on the basis of central obesity - assessed by waist circumference - plus two or more of the following cardio-metabolic risks according to Japanese criteria: high blood pressure, hyperglycemia, and lipid abnormality. Central obesity plus one of the risks was defined as preMetS. Results Men had a significantly higher prevalence of MetS (23.3% vs. 8.7%, p<0.001) and preMetS (21.2% vs. 10.2%, p<0.001) than women. An age-adjusted logistic regression analysis revealed that heavy drinkers were associated with an increased probability of MetS (odds ratio, 1.91: 95% confidence interval, 1.29-2.83) and preMetS (1.69: 1.11-2.58); fast eaters were also related to preMetS (1.83: 1.33-2.55) and MetS (1.55: 1.12-2.15) in men. Lacking regular exercise was significantly associated with preMetS (1.38: 1.03-1.85), but not MetS. In women, preMetS was significantly associated with fast eaters and lacking regular exercise (1.44: 1.01-2.07 and 1.41: 1.02-1.96, respectively); a stepwise increase in each odds ratio (2.02: 1.40-2.91 and 1.47: 1.03-2.09, respectively) was also observed for MetS. Conclusion The relationships between lifestyle factors and MetS or preMetS differed between men and women, which suggests the need for gender-specific lifestyle modification to effectively prevent MetS.

  2. Factors influencing deprescribing for residents in Advanced Care Facilities: insights from General Practitioners in Australia and Sweden.

    Science.gov (United States)

    Bolmsjö, Beata Borgström; Palagyi, Anna; Keay, Lisa; Potter, Jan; Lindley, Richard I

    2016-11-05

    General Practitioners (GPs) are responsible for primary prescribing decisions in most settings. Elderly patients living in Advanced Care Facilities (ACFs) often have significant co-morbidities to consider when selecting an appropriate drug therapy. Careful assessment is required when considering appropriate medication use in frail older patients as they have multiple diseases and thus multiple medication. Many physicians seem reluctant to discontinue other physicians' prescriptions, resulting in further polypharmacy. Therefore it is relevant to ascertain and synthesise the GP views from multiple settings to understand the processes that might promote appropriate deprescribing medications in the elderly. The aims of this study were to 1) compare and contrast behavioural factors influencing the deprescribing practices of GPs providing care for ACF residents in two separate countries, 2) review health policy and ACF systems in each setting for their potential impact on the prescribing of medications for an older person in residential care of the elderly, and 3) based on these findings, provide recommendations for future ACF deprescribing initiatives. A review and critical synthesis of qualitative data from two interview studies of knowledge, attitudes, and behavioural practices held by GPs towards medication management and deprescribing for residents of ACFs in Australia and Sweden was conducted. A review of policies and health care infrastructure was also carried out to describe the system of residential aged care in the both countries. Our study has identified that deprescribing by GPs in ACFs is a complex process and that there are numerous barriers to medication reduction for aged care residents in both countries, both with similarities and differences. The factors affecting deprescribing behaviour were identified and divided into: intentions, skills and abilities and environmental factors. In this study we show that the GPs' behaviour of deprescribing in two

  3. Factor structure of the General Health Questionnaire-28 (GHQ-28 from infertile women attending the Yazd Research and Clinical Center for Infertility

    Directory of Open Access Journals (Sweden)

    Zahra Shayan

    2015-12-01

    Full Text Available Background: Nowadays, infertility problems have become a social concern, and are associated with multiple psychological and social problems. Also, it affects the interpersonal communication between the individual, familial, and social characteristics. Since women are exposed to stressors of physical, mental, social factors, and treatment of infertility, providing a psychometric screening tool is necessary for disorders of this group. Objective: The aim of this study was to determine the factor structure of the general health questionnaire-28 to discover mental disorders in infertile women. Materials and Methods: In this study, 220 infertile women undergoing treatment of infertility were selected from the Yazd Research and Clinical Center for Infertility with convenience sampling in 2011. After completing the general health questionnaire by the project manager, validity and, reliability of the questionnaire were calculated by confirmatory factor structure and Cronbach's alpha, respectively. Results: Four factors, including anxiety and insomnia, social dysfunction, depression, and physical symptoms were extracted from the factor structure. 50.12% of the total variance was explained by four factors. The reliability coefficient of the questionnaire was obtained 0.90. Conclusion: Analysis of the factor structure and reliability of General Health Questionnaire-28 showed that it is suitable as a screening instrument for assessing general health of infertile women.

  4. New Media Display Technology and Exhibition Experience

    Directory of Open Access Journals (Sweden)

    Chen-Wo Kuo

    2016-01-01

    Full Text Available As the inheritor of Chinese civilization, the National Palace Museum (hereafter referred to as the NPM, houses a world-class collection of cultural art and artifacts. Since the NPM began promoting the National Digital Archives Project in 2002, its efforts have expanded to develop a digital museum and various e-learning programs. Extending the use of digital archives to its educational and cultural industrial endeavors, the NPM has maximized the value of its exhibitions, publications, and educational programs.  In 2013, the NPM integrated creative thinking and interdisciplinary technologies, such as floating projection, augmented reality, and other sensory interactive media, to recreate the historical circumstance of 19th century East Asian maritime cultures in “Rebuilding the Tong-an Ships—New Media Art Exhibition," which opened at Huashan 1914 Creative Park and later won the Gold Award at the 2014 Digital Education Innovation Competition. Through a thorough exploration of the factors contributing to the success of "Rebuilding the Tong-an Ships," this study has isolated the two main factors of the exhibition’s popularity, namely, the compactness of the metadata and the atmosphere created by the interactive display technology.

  5. The Globe: Exhibitions and Events

    CERN Document Server

    2008-01-01

    Globe of Science and Innovation 1st floor Route de Meyrin, 1211 Geneva Friday, 26 September at 8.30 p.m. Play (in French) Higgs and the co(s)mic duo, Bouvard and Pécuchet, by François Vannucci with Alexis Roque, Romain Starck and François Vannucci After their return from a voyage of discovery into the world of the neutrino, Bouvard and Pécuchet try to understand the new physics that the LHC will be exploring. Open to members of the general public. Entrance free. To reserve call +41 (0)22 767 76 76 All Globe events at: http://www.cern.ch/globe

  6. The Adenovirus E4-ORF3 Protein Stimulates SUMOylation of General Transcription Factor TFII-I to Direct Proteasomal Degradation

    Directory of Open Access Journals (Sweden)

    Rebecca G. Bridges

    2016-01-01

    Full Text Available Modulation of host cell transcription, translation, and posttranslational modification processes is critical for the ability of many viruses to replicate efficiently within host cells. The human adenovirus (Ad early region 4 open reading frame 3 (E4-ORF3 protein forms unique inclusions throughout the nuclei of infected cells and inhibits the antiviral Mre11-Rad50-Nbs1 DNA repair complex through relocalization. E4-ORF3 also induces SUMOylation of Mre11 and Nbs1. We recently identified additional cellular targets of E4-ORF3 and found that E4-ORF3 stimulates ubiquitin-like modification of 41 cellular proteins involved in a wide variety of processes. Among the proteins most abundantly modified in an E4-ORF3-dependent manner was the general transcription factor II–I (TFII-I. Analysis of Ad-infected cells revealed that E4-ORF3 induces TFII-I relocalization and SUMOylation early during infection. In the present study, we explored the relationship between E4-ORF3 and TFII-I. We found that Ad infection or ectopic E4-ORF3 expression leads to SUMOylation of TFII-I that precedes a rapid decline in TFII-I protein levels. We also show that E4-ORF3 is required for ubiquitination of TFII-I and subsequent proteasomal degradation. This is the first evidence that E4-ORF3 regulates ubiquitination. Interestingly, we found that E4-ORF3 modulation of TFII-I occurs in diverse cell types but only E4-ORF3 of Ad species C regulates TFII-I, providing critical insight into the mechanism by which E4-ORF3 targets TFII-I. Finally, we show that E4-ORF3 stimulates the activity of a TFII-I-repressed viral promoter during infection. Our results characterize a novel mechanism of TFII-I regulation by Ad and highlight how a viral protein can modulate a critical cellular transcription factor during infection.

  7. Gene transcripts encoding hypoxia-inducible factor (HIF) exhibit tissue- and muscle fiber type-dependent responses to hypoxia and hypercapnic hypoxia in the Atlantic blue crab, Callinectes sapidus.

    Science.gov (United States)

    Hardy, Kristin M; Follett, Chandler R; Burnett, Louis E; Lema, Sean C

    2012-09-01

    Hypoxia inducible factor (HIF) is a transcription factor that under low environmental oxygen regulates the expression of suites of genes involved in metabolism, angiogenesis, erythropoiesis, immune function, and growth. Here, we isolated and sequenced partial cDNAs encoding hif-α and arnt/hif-β from the Atlantic blue crab, Callinectes sapidus, an estuarine species that frequently encounters concurrent hypoxia (low O(2)) and hypercapnia (elevated CO(2)). We then examined the effects of acute exposure (1h) to hypoxia (H) and hypercapnic hypoxia (HH) on relative transcript abundance for hif-α and arnt/hif-β in different tissues (glycolytic muscle, oxidative muscle, hepatopancreas, gill, and gonads) using quantitative real-time RT-PCR. Our results indicate that hif-α and arnt/hif-β mRNAs were constitutively present under well-aerated normoxia (N) conditions in all tissues examined. Further, H and HH exposure resulted in both tissue-specific and muscle fiber type-specific effects on relative hif-α transcript abundance. In the gill and glycolytic muscle, relative hif-α mRNA levels were significantly lower under H and HH, compared to N, while no change (or a slight increase) was detected in oxidative muscle, hepatopancreas and gonadal tissues. H and HH did not affect relative transcript abundance for arnt/hif-β in any tissue or muscle fiber type. Thus, in crustaceans the HIF response to H and HH appears to involve changes in hif transcript abundance, with variation in hif-α and arnt/hif-β transcriptional dynamics occurring in both a tissue- and muscle fiber type-dependent manner. Copyright © 2012 Elsevier Inc. All rights reserved.

  8. ASSESSMENT OF THE MAGNITUDE OF TEENAGE PREGNANCY AND ITS ASSOCIATED FACTORS AMONG TEENAGE FEMALES VISITING ASSOSA GENERAL HOSPITAL.

    Science.gov (United States)

    Beyene, Assefa; Muhiye, Abiyou; Getachew, Yeneneh; Hiruye, Abiy; Mariam, Damen Haile; Derbew, Millard; Mammo, Dereje; Enquselassie, Fikre

    2015-07-01

    Teenage pregnancy is directly related to high incidence of pregnancy related complications contributing to maternal morbidity and mortality and social problems. There are no enough data on teenage pregnancy and related complications in Ethiopia and in Benishangul Gumuz region in particular. To investigate the magnitude and factors associated with teenage pregnancy among teenage females visiting Assosa general hospital for health care services. Facility-based quantitative cross-sectional study was carried out among 783 randomly selected teenage females using structured and pre-tested questionnaire from January to April 2014. Teenage pregnancy is estimated at 20.4% in this study. The median age of subjects at first sexual intercourse and at first marriage being 16 and 17 years respectively. High proportion of (46.8%) teenagers had engaged in premarital sex. Among sexually active teenage females, 46.7% experienced their first sexual encounter by coercion. Being young [AOR = 0.21, 95% CI = 0.06-0.67], single [AOR = 0.06, 95% CI = 0.03-0.12], housemaid [AOR = 3.93, 95% CI = 1.71-9.04] and use of family planning [AOR = 2.39, 95% CI = 1.20-4.75] have statistically significant association with teenage pregnancy. A range offactors including age, marital status, level of education, occupational status, average family income and use of family planning have influence on teenage pregnancy in the study area. Behavioral change communication, strengthening school health program, empowering young women specifically the rural women, and promoting parent-children discussion on sexuality is recommended.

  9. Diabetes mellitus type II as a risk factor for depression: a lower than expected risk in a general practice setting.

    Science.gov (United States)

    Aarts, S; van den Akker, M; van Boxtel, M P J; Jolles, J; Winkens, B; Metsemakers, J F M

    2009-01-01

    The aim of the present study was to determine whether a diagnosis of diabetes mellitus (DM) in a primary setting is associated with an increased risk of subsequent depression. A retrospective cohort design was used based on the Registration Network Family Practice (RNH) database. Patients diagnosed with diabetes mellitus at or after the age of 40 and who were diagnosed between 01-01-1980 and 01-01-2007 (N = 6,140), were compared with age-matched controls from a reference group (N = 18,416) without a history of diabetes. Both groups were followed for an emerging first diagnosis of depression (and/or depressive feelings) until January 1, 2008. 2.0% of the people diagnosed with diabetes mellitus developed a depressive disorder, compared to 1.6% of the reference group. After statistical correction for confounding factors diabetes mellitus was associated with an increased risk of developing subsequent depression (HR 1.26; 95% CI: 1.12-1.42) and/or depressive feelings (HR 1.33; 95% CI: 1.18-1.46). After statistical adjustment practice identification code, age and depression preceding diabetes, were significantly related to a diagnosis of depression. Patients with diabetes mellitus are more likely to develop subsequent depression than persons without a history of diabetes. Results from this large longitudinal study based on a general practice population indicate that this association is weaker than previously found in cross-sectional research using self-report surveys. Several explanations for this dissimilarity are discussed

  10. Dyslipidemia and associated factors among diabetic patients attending Durame General Hospital in Southern Nations, Nationalities, and People’s Region

    Directory of Open Access Journals (Sweden)

    Bekele S

    2017-06-01

    Full Text Available Shiferaw Bekele, Tagesech Yohannes, Abdurehman Eshete Mohammed Department of Medical Laboratory Sciences, College of Health Sciences, Jimma University, Jimma, Ethiopia Background: Diabetes mellitus is a group of metabolic disorders that are caused by deficiency in insulin secretion or the decreased ability of insulin to act effectively on target tissues, particularly muscle, liver, and fat. As a result of insulin resistance in the target tissues, particularly in the adipocytes, free fatty acid flux is increased, leading to increased lipid synthesis in hepatocytes, which is responsible for diabetic dyslipidemia.Objective: The objective of this study was to determine the prevalence and associated factors of dyslipidemia among diabetic patients in Durame General Hospital in Kembata Tembaro zone.Methods: A cross-sectional study was conducted from September 2015 to April 2016. In total, 224 subjects were involved in the study by using convenient sampling techniques. Face-to-face interview–administered questionnaire was used to collect sociodemographic data and other possible clinical data associated with the prevalence of dyslipidemia. Fasting venous blood specimens were collected to assess serum lipid profiles. Blood pressure (BP, weight, height, and waist circumference were measured.Results: The prevalence of dyslipidemia was 65.6%. Individual lipid abnormality of elevated LDL-C, TC, TG, and reduced HDL-C were identified in 43.8%, 23.7%, 40.6%, and 41.9% of study subjects, respectively. The prevalence of dyslipidemia was significantly associated with high BP, high body mass index, aging, and longer duration of diabetes mellitus. Conclusion: High prevalence of dyslipidemia was found among diabetic patients in the study area. Therefore, a compressive mechanism is required to screen, treat, and prevent dyslipidemia. Keywords: diabetes, lipid profile, Jimma, Ethiopia

  11. The Dimensionality of the General Aptitude Test Battery (GATB) and the Dominance of General Factors over Specific Factors in the Prediction of Job Performance for the U.S. Employment Service.

    Science.gov (United States)

    Hunter, John E.

    The structure of this report is as follows: First, specific aptitude theory and general ability theory, the two theories of the relation between ability and job performance, are presented and differentiated. Second, there is a discussion of problems in the current use of the General Aptitude Test Battery (GATB) and of problems in the use of…

  12. Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor

    Directory of Open Access Journals (Sweden)

    Hoang Anh Vu

    2010-01-01

    Full Text Available The exact molecular mechanism by which epigallocatechin gallate (EGCG suppresses human pancreatic cancer cell proliferation is unclear. We show here that EGCG-treated pancreatic cancer cells AsPC-1 and BxPC-3 decrease cell adhesion ability on micro-pattern dots, accompanied by dephosphorylations of both focal adhesion kinase (FAK and insulin-like growth factor-1 receptor (IGF-1R whereas retained the activations of mitogen-activated protein kinase and mammalian target of rapamycin. The growth of AsPC-1 and BxPC-3 cells can be significantly suppressed by EGCG treatment alone in a dose-dependent manner. At a dose of 100 μM which completely abolishes activations of FAK and IGF-1R, EGCG suppresses more than 50% of cell proliferation without evidence of apoptosis analyzed by PARP cleavage. Finally, the MEK1/2 inhibitor U0126 enhances growth-suppressive effect of EGCG. Our data suggests that blocking FAK and IGF-1R by EGCG could prove valuable for targeted therapy, which can be used in combination with other therapies, for pancreatic cancer.

  13. Examination of the interrelations between the factors of PTSD, major depression, and generalized anxiety disorder in a heterogeneous trauma-exposed sample using DSM 5 criteria.

    Science.gov (United States)

    Price, Matthew; van Stolk-Cooke, Katherine

    2015-11-01

    Exposure to traumatic events places individuals at high risk for multiple psychiatric disorders, including posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and generalized anxiety disorder (GAD). The high rates of comorbidity among these conditions merit evaluation in order to improve diagnosis and treatment approaches. The current study evaluated the association between PTSD, MDD, and GAD factors as presented in the DSM 5. 602 trauma-exposed individuals who experienced an event that met Criterion A for the DSM 5 PTSD diagnosis were recruited through Amazon.com, Inc.'s Mechanical Turk (MTurk) to complete an assessment of the impact of stressful events on their lives. High interrelations were detected among the 4 PTSD factors, 2 MDD factors that corresponded to somatic and affective symptoms, and the single GAD factor. The affective factor of MDD was most strongly related to the emotional numbing factor of PTSD, whereas the somatic factor of MDD was most strongly related to the hyperarousal factor of PTSD. The GAD factor was most strongly related to the hyperarousal factor of PTSD, relative to the other PTSD factors. The strength of the interrelations between factors of the three disorders is largely a function of the overlap in symptoms and calls into question the uniqueness of negative affective symptoms of PTSD, MDD and GAD. Results suggest that improved understanding of the trauma reaction requires a focus on the unique presentation of each individual and assessment of multiple disorders.

  14. Hypothesis: Is frequent, commercial jet travel by the general public a risk factor for developing cutaneous melanoma? [version 1; referees: 2 approved, 1 approved with reservations

    Directory of Open Access Journals (Sweden)

    Harvey Arbesman

    2015-08-01

    Full Text Available Melanoma incidence has been increasing worldwide over the past 50 years and various risk factors have been identified. Interestingly, multiple studies have shown a multifold increased risk of developing melanoma in jet pilots and airline crew. There has also been a dramatic increase in the availability and frequency of jet travel by the general population during this time period.. Therefore, it is hypothesized that frequent commercial jet travel may represent an additional risk factor for the development of cutaneous melanoma in susceptible individuals of the general public.

  15. Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box.

    Science.gov (United States)

    Horikoshi, M; Wang, C K; Fujii, H; Cromlish, J A; Weil, P A; Roeder, R G

    1989-09-28

    The TATA sequence-binding factor TFIID plays a central role both in promoter activation by RNA polymerase II and other common initiation factors, and in promoter regulation by gene-specific factors. The sequence of yeast TFIID, which seems to be encoded by a single gene, contains interesting structural motifs that are possibly involved in these functions, and is similar to sequences of bacterial sigma factors.

  16. Matrix Metalloproteinase-2-deficient Fibroblasts Exhibit an Alteration in the Fibrotic Response to Connective Tissue Growth Factor/CCN2 because of an Increase in the Levels of Endogenous Fibronectin*

    Science.gov (United States)

    Droppelmann, Cristian A.; Gutiérrez, Jaime; Vial, Cecilia; Brandan, Enrique

    2009-01-01

    Matrix metalloproteinase-2 (MMP-2) is an important extracellular matrix remodeling enzyme, and it has been involved in different fibrotic disorders. The connective tissue growth factor (CTGF/CCN2), which is increased in these pathologies, induces the production of extracellular matrix proteins. To understand the fibrotic process observed in diverse pathologies, we analyzed the fibroblast response to CTGF when MMP-2 activity is inhibited. CTGF increased fibronectin (FN) amount, MMP-2 mRNA expression, and gelatinase activity in 3T3 cells. When MMP-2 activity was inhibited either by the metalloproteinase inhibitor GM-6001 or in MMP-2-deficient fibroblasts, an increase in the basal amount of FN together with a decrease of its levels in response to CTGF was observed. This paradoxical effect could be explained by the fact that the excess of FN could block the access to other ligands, such as CTGF, to integrins. This effect was emulated in fibroblasts by adding exogenous FN or RGDS peptides or using anti-integrin αV subunit-blocking antibodies. Additionally, in MMP-2-deficient cells CTGF did not induce the formation of stress fibers, focal adhesion sites, and ERK phosphorylation. Anti-integrin αV subunit-blocking antibodies inhibited ERK phosphorylation in control cells. Finally, in MMP-2-deficient cells, FN mRNA expression was not affected by CTGF, but degradation of 125I-FN was increased. These results suggest that expression, regulation, and activity of MMP-2 can play an important role in the initial steps of fibrosis and shows that FN levels can regulate the cellular response to CTGF. PMID:19276073

  17. The Exhibition Performance Appraisal Index System Based on Stakeholder Theory

    Institute of Scientific and Technical Information of China (English)

    YAN Shu-min; HAO Qi-hui

    2009-01-01

    Exhibition performance should be evaluated from different perspectives of stakeholders. The benefits of each stakeholder can not be satisfied when evaluating the exhibition performance from a single perspective or. only evaluating the economic performance of the exhibition. In this paper, the stakeholders are defined on the basis of questionnaire investigation and classified by mathematical statistical method. According to the requirements of the stakeholders, the exhibition performance appraisal indicators are extracted and, simplified by factor analysis, which leads to the formation of a set of performance appraisal index system. It is an instructive attempt to work out the exhibition performance appraisal model from the perspective of stakeholders, which may provide theoretical foundation and practice instruction for exhibition performance appraisal in our country.

  18. Effects of workplace, family and cultural influences on low back pain: what opportunities exist to address social factors in general consultations?

    Science.gov (United States)

    Shaw, William S; Campbell, Paul; Nelson, Candace C; Main, Chris J; Linton, Steven J

    2013-10-01

    Social factors are widely acknowledged in behavioural models of pain and pain management, but incorporating these factors into general medical consultations for low back pain (LBP) can be challenging. While there is no compelling evidence that social factors contribute to LBP onset, these factors have been shown to influence functional limitation and disability, especially the effects of organisational support in the workplace, spousal support, family conflict and social disadvantage. A number of barriers exist to address such social factors in routine medical encounters for LBP, but there is emerging evidence that improving social and organisational support may be an effective strategy to reduce the negative lifestyle consequences of LBP. For clinicians to address these factors in LBP treatment requires a clearer psychosocial framework in assessment and screening, more individualised problem-solving efforts, more patient-centred interventions involving family, peers and workplace supports and a less biomechanical and diagnostic approach.

  19. Growth of Self-Perceived Clinical Competence in Postgraduate Training for General Practice and Its Relation to Potentially Influencing Factors

    Science.gov (United States)

    Kramer, A. W. M.; Zuithoff, P.; Jansen, J. J. M.; Tan, L. H. C.; Grol, R. P. T. M.; van der Vleuten, C. P. M.

    2007-01-01

    Objective: To examine the increase in self-perceived clinical competence during a three-year postgraduate training in general practice and to explore the relation between the growth of self-perceived competence and several background variables. Design: Cohort, 1995-1998. Setting: Three-year Postgraduate Training for General practice in the…

  20. Study protocol: Transition from localized low back pain to chronic widespread pain in general practice: Identification of risk factors, preventive factors and key elements for treatment – A cohort study

    Directory of Open Access Journals (Sweden)

    Viniol Annika

    2012-05-01

    Full Text Available Abstract Background Chronic localized pain syndromes, especially chronic low back pain (CLBP, are common reasons for consultation in general practice. In some cases chronic localized pain syndromes can appear in combination with chronic widespread pain (CWP. Numerous studies have shown a strong association between CWP and several physical and psychological factors. These studies are population-based cross-sectional and do not allow for assessing chronology. There are very few prospective studies that explore the predictors for the onset of CWP, where the main focus is identifying risk factors for the CWP incidence. Until now there have been no studies focusing on preventive factors keeping patients from developing CWP. Our aim is to perform a cross sectional study on the epidemiology of CLBP and CWP in general practice and to look for distinctive features regarding resources like resilience, self-efficacy and coping strategies. A subsequent cohort study is designed to identify the risk and protective factors of pain generalization (development of CWP in primary care for CLBP patients. Methods/Design Fifty-nine general practitioners recruit consecutively, during a 5 month period, all patients who are consulting their family doctor because of chronic low back pain (where the pain is lasted for 3 months. Patients are asked to fill out a questionnaire on pain anamnesis, pain-perception, co-morbidities, therapy course, medication, socio demographic data and psychosomatic symptoms. We assess resilience, coping resources, stress management and self-efficacy as potential protective factors for pain generalization. Furthermore, we raise risk factors for pain generalization like anxiety, depression, trauma and critical life events. During a twelve months follow up period a cohort of CLBP patients without CWP will be screened on a regular basis (3 monthly for pain generalization (outcome: incident CWP. Discussion This cohort study will be the largest

  1. A General Factor of Personality in 16 sets of the Big Five, the Guilford-Zimmerman Temperament Survey, the California Psychological Inventory, and the Temperament and Character Inventory

    OpenAIRE

    Rushton, J. Philippe; Irwing, Paul

    2009-01-01

    In four studies, we tested the hypothesis that a General Factor of Personality (GFP) occupies the apex of the hierarchy. In Study 1, a GFP was found in 16 sets of Big Five inter-scale correlations (N = 6412) which explained 54% of the variance in the two first-order factors. In Study 2, a GFP was found in validation samples from the Guilford-Zimmerman Temperament Survey (N = 2917) which explained 36% of the variance in three first-order factors and 21% of the total reliable variance in a mode...

  2. The General Public’s Awareness of Early Symptoms of and Emergency Responses to Acute Myocardial Infarction and Related Factors in South Korea: A National Public Telephone Survey

    Directory of Open Access Journals (Sweden)

    Hee-Sook Kim

    2016-05-01

    Full Text Available Background: Prompt treatment affects prognosis and survival after acute myocardial infarction (AMI onset. This study evaluated the awareness of early symptoms of AMI and knowledge of appropriate responses on symptom occurrence, along with related factors. Methods: Participants’ knowledge of the early symptoms of and responses to AMI onset were investigated using a random digit dialing survey. We included 9600 residents of 16 metropolitan cities and provinces in Korea. Results: The proportions of respondents who were aware of early symptoms of AMI ranged from 32.9% (arm or shoulder pain to 79.1% (chest pain and discomfort. Of the respondents, 67.0% would call an ambulance if someone showed signs of AMI, 88.7% knew ≥1 symptom, 10.9% knew all five symptoms, and 3.1% had excellent knowledge (correct identification of all five AMI symptoms, not answering “Yes” to the trap question, and correctly identifying calling an ambulance as the appropriate response when someone is exhibiting AMI symptoms. The odds ratio (OR for having excellent knowledge was significantly higher for those who graduated college or higher (OR 3.42; 95% confidence interval [CI], 1.09–10.76 than for those with less than a primary school education, as well as for subjects with AMI advertisement exposure (OR 1.49; 95% CI, 1.10–2.02 and with knowledge of AMI (OR 1.63; 95% CI, 1.16–2.27. The 60- to 79-year-old group had significantly lower OR for excellent knowledge than the 20- to 39-year-old group (OR 0.53; 95% CI, 0.28–0.99. Conclusions: Awareness of AMI symptoms and the appropriate action to take after symptom onset in South Korea was poor. Therefore, educational and promotional strategies to increase the overall awareness in the general public, especially in the elderly and those with low education levels, are needed.

  3. Big Five Personality Traits and the General Factor of Personality as Moderators of Stress and Coping Reactions Following an Emergency Alarm on a Swiss University Campus

    NARCIS (Netherlands)

    M.P. Hengartner (Michael P.); D. van der Linden (Dimitri); L. Bohleber (Laura); A. von Wyl (Agnes)

    2017-01-01

    textabstractWe conducted an online survey including 306 participants aged 18-64years to assess the general factor of personality (GFP) and Big Five personality traits in relation to individual stress and coping reactions following a shooting emergency alarm at a Swiss university campus. Although the

  4. Presentation and exhibition activities for promoting theexportof transport services

    Directory of Open Access Journals (Sweden)

    Darya Vladimirovna Nesterova

    2012-03-01

    Full Text Available Development of presentation and exhibition activities is considered as an important factor in providing new competitive advantages at the strategic markets for exporting of transportation services. A specific role for exhibition activities as a factor to overcome market failures arose from imperfect information and incomplete markets is displayed. Exhibitions are considered as a true reflection of most market parameters, as a means to get correct information concerning market capacity and its borders, as an instrument to access to new markets. At the firm level presentation and branding activities should be considered as a modern technology (especially it concerns Russian companies which provide to hold up already existed markets and to conquer new ones. Presentation and branding activities are an effective technology to promote company trade-mark, competitive advantages for market demand increasing. Comparative analysis of the main exhibitions on transport and logistics issues is fulfilled on the data basecollected by authors. Data observes geographical distribution of transport exhibition and exhibition facilities development at several regions for the last years. The analyses allow to revealing a geographical structure of the exhibitions and its distribution by type of transport. The most promising and economically favorable exhibition areas for the promotion of Russian transport services are shown.

  5. 21 March 2011 - South African Ministry of Science and Technology, Department of Science and Technology (DST) Director General P. Mjwara signing the guest with Head of International Relations F. Pauss and Adviser J. Ellis and ALICE Collaboration Spokesperson P. Giubellino and J. Cleymans; in the CERN control centre with R. Steerenberg; visiting ALICE surface exhibition with P. Giubellino and LHC superconducting magnet test hall with L. Bottura.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    21 March 2011 - South African Ministry of Science and Technology, Department of Science and Technology (DST) Director General P. Mjwara signing the guest with Head of International Relations F. Pauss and Adviser J. Ellis and ALICE Collaboration Spokesperson P. Giubellino and J. Cleymans; in the CERN control centre with R. Steerenberg; visiting ALICE surface exhibition with P. Giubellino and LHC superconducting magnet test hall with L. Bottura.

  6. CERN’s travelling exhibition goes to Austria

    CERN Document Server

    Mélissa Lanaro

    2011-01-01

    Since April 2009 CERN’s travelling exhibition has been touring through some of the Organization's Member States. After Italy and Denmark it has been on show since February at Austria’s Hartberg Ökopark, a very popular science museum situated some one hundred kilometres from Vienna. To coincide with the CERN exhibition, Austria’s scientific community has organised a series of events for the general public which have had marked success. The exhibition's next destination will be Portugal and preparations are already underway to ensure that it is another resounding success   The travelling exhibition was designed in collaboration with the University of Geneva, as part of the celebrations for its 450th anniversary, and has already notched up a good number of kilometres as it travels from country to country. “In 2010 the exhibition already had around 55,000 visitors,” explains Rolf Landua, who heads the Education Group. Since its inauguration ...

  7. Factorization of J-unitary matrix polynomials on the line and a Schur algorithm for generalized Nevanlinna functions

    NARCIS (Netherlands)

    Alpay, D.; Dijksma, A.; Langer, H.

    2004-01-01

    We prove that a 2 × 2 matrix polynomial which is J-unitary on the real line can be written as a product of normalized elementary J-unitary factors and a J-unitary constant. In the second part we give an algorithm for this factorization using an analog of the Schur transformation.

  8. Do work-related factors affect care-seeking in general practice for back pain or upper extremity pain?

    DEFF Research Database (Denmark)

    Jensen, J. C.; Haahr, J. P.; Frost, P.

    2012-01-01

    . Repetitive work and psychosocial factors did not have any statistically significant impact on care-seeking for neither back pain nor upper extremity pain. CONCLUSION: Work-related factors such as heavy lifting do, to some extent, contribute to care-seeking with MP. We suggest that asking the patient about...

  9. Risk factors for more severe regional musculoskeletal symptoms: a two-year prospective study of a general working population

    DEFF Research Database (Denmark)

    Andersen, JH; Haahr, J. P.; Frost, P.

    2007-01-01

    OBJECTIVE: To quantify the relative contribution of work-related physical and psychosocial factors, individual factors, and health-related factors to the development of more severe musculoskeletal pain in the neck and upper limbs and the back and lower limbs. METHODS: In this cohort study of 5......,604 workers from industrial and service companies, we collected information on work-related physical and psychosocial exposures and on individual and health-related factors. Questionnaires were completed at baseline by 4,006 participants (71.5%) and after 24 months by 3,276 (82%). At followup, participants....... Highly repetitive work predicted arm pain, heavy lifting and prolonged standing predicted low back pain, and heavy pushing or pulling predicted lower limb pain. Low job satisfaction predicted neck/shoulder pain and lower limb pain, whereas other psychosocial work place factors were only of marginal...

  10. Polar Factorization and Generalized Inverse for Row (Column) Skew Symmetric Matrix%行(列)反对称矩阵的极分解及其广义逆

    Institute of Scientific and Technical Information of China (English)

    袁晖坪

    2013-01-01

    The author studied the polar factorization and generalized inverse of row (column) skew symmetric matrix, which leads to some new results. In addition, the formula of the polar factorization and generalized inverse of row (column) skew symmetric matrix were given, which makes calculation easier, and some perturbation bounds of polar factorization of row (column) skew symmetric matrix were also presented.%考虑行(列)反对称矩阵的极分解和广义逆,给出了行(列)反对称矩阵的极分解和广义逆计算公式,并对行(列)反对称矩阵的极分解作了扰动分析.结果表明,所给方法既减少了计算量与存储量,又保证了数值精度.

  11. 行(列)对称矩阵的极分解与广义逆%Polar Factorization and Generalized Inverse for Row (Column)Symmetric Matrix

    Institute of Scientific and Technical Information of China (English)

    袁晖坪

    2015-01-01

    考虑行(列)对称矩阵的极分解与广义逆,给出了行(列)对称矩阵的极分解和广义逆的计算公式,并导出了行(列)对称矩阵极分解的系列扰动界。结果表明,所给方法既减少了计算量与存储量,又不会降低数值精度。%The author studied the polar factorization and generalized inverse of row (column ) symmetric matrix.In addition,the formulae of the polar factorization and generalized inverse of row (column) symmetric matrix were given,which make calculation easier.And some perturbation bounds of the polar factorization of row (column)symmetric matrix were also presented.

  12. Development Report on Exhibition Industry in Guangzhou

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Ⅰ. Generat Features of Guangzhou Exhibitions (Ⅰ) Quantity of Exhibitions and Industry Features. Overall, after suf-fering from global financial crisis in 2008 as well as the interference of Beijing Olympic Games and other major events, the exhibition industry in Guangzhou has still not encountered an easy condition in 2009.

  13. Beijing Lack of "Carrier"Exhibition Center

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    An Interview towards Mr. Chu Xiangyin, Vice Chairman of Beijing Subcouncil, CCPIT Reporter: Would you please tell us development of exhibition industry in Beijing? Chu Xiangyin: Beijing Statistical Bureau and us have been designing and analyzing statistical system for exhibition industry from 2003. As the largest exhibition center in Beijing,

  14. Risk factors for incident delirium in an acute general medical setting: a retrospective case-control study.

    Science.gov (United States)

    Tomlinson, Emily Jane; Phillips, Nicole M; Mohebbi, Mohammadreza; Hutchinson, Alison M

    2017-03-01

    To determine predisposing and precipitating risk factors for incident delirium in medical patients during an acute hospital admission. Incident delirium is the most common complication of hospital admission for older patients. Up to 30% of hospitalised medical patients experience incident delirium. Determining risk factors for delirium is important for identifying patients who are most susceptible to incident delirium. Retrospective case-control study with two controls per case. An audit tool was used to review medical records of patients admitted to acute medical units for data regarding potential risk factors for delirium. Data were collected between August 2013 and March 2014 at three hospital sites of a healthcare organisation in Melbourne, Australia. Cases were 161 patients admitted to an acute medical ward and diagnosed with incident delirium between 1 January 2012 and 31 December 2013. Controls were 321 patients sampled from the acute medical population admitted within the same time range, stratified for admission location and who did not develop incident delirium during hospitalisation. Identified using logistic regression modelling, predisposing risk factors for incident delirium were dementia, cognitive impairment, functional impairment, previous delirium and fracture on admission. Precipitating risk factors for incident delirium were use of an indwelling catheter, adding more than three medications during admission and having an abnormal sodium level during admission. Multiple risk factors for incident delirium exist; patients with a history of delirium, dementia and cognitive impairment are at greatest risk of developing delirium during hospitalisation. Nurses and other healthcare professionals should be aware of patients who have one or more risk factors for incident delirium. Knowledge of risk factors for delirium has the potential to increase the recognition and understanding of patients who are vulnerable to delirium. Early recognition and

  15. CERN Industrials Exhibitions - Over 30 Years of Tradition

    CERN Multimedia

    2001-01-01

    Industrial exhibitions have been part of the CERN landscape for 33 years. At least once each year several companies from the same country come to CERN to present their products and services. Now, a new scheme of one-day visits is giving potential exhibitors at CERN a lighter option. The United Kingdom inaugurated the Industrial Exhibitions in 1968, and it wasn't till 1971 that other countries staged exhibitions at CERN. This photo was taken in 1969, at the second British exhibition, where 16 companies were present. Four years after joining CERN, Poland inaugurated its first exhibition at CERN in 1995 in the presence of the former Director-General Chris Llewellyn-Smith. Almost all the Member States have held industrial exhibitions at the Organization. May '68 wasn't only revolutionary in Paris. For the very first time, an industrial exhibition took place at CERN. Great Britain was first to come with eight companies and remains until this day the most devoted country to the programme with 17 exhibitions and ...

  16. Designing museum exhibits that facilitate visitor reflection and discussion

    DEFF Research Database (Denmark)

    Skydsgaard, Morten Arnika; Andersen, Hanne Møller; King, Heather

    2016-01-01

    personal reflection but also prompted discussion. Participation, defined as including both physical interaction with exhibits, and dialogic interaction between visitors, facilitated the sharing of ideas and feelings between visitors. Exhibits with elements of curiosity and challenge were found to attract...... pupils’ attention but also worked well with other design principles to engage the pupils in sustained reflection and discussion. While other contextual factors remain significant in determining visitor responses, this paper argues that the use of design principles can help create visitor experiences...

  17. CREATION OF PUBLIC DIGITAL EDUCATIONAL RESOURCES FOR SECONDARY SCHOOLS AS AN IMPORTANT FACTOR FOR IMPROVING OF GENERAL EDUCATION QUALITY

    Directory of Open Access Journals (Sweden)

    Anatolii Yu. Pylypchuk

    2010-08-01

    Full Text Available The article deals with the problems that must be addressed for digital educational resources to meet current requirements and to ensure their general education, analyzed ways to solve these problems abroad, particularly in the Russian Federation, and suggested possible ways to address them in Ukraine.

  18. Sexual orientation and health : general and minority stress factors explaining health differences between lesbian, gay, bisexual and heterosexual individuals

    NARCIS (Netherlands)

    Kuyper, L.S.

    2011-01-01

    Previous studies show that lesbian, gay and bisexual (LGB) individuals report more health problems than heterosexual individuals. However, several important gaps remain in the knowledge regarding the explanations for these health differences. In general, there is a lack of differentiation between

  19. The Influence of Self-Efficacy and Motivational Factors on Academic Performance in General Chemistry Course: A Modeling Study

    Science.gov (United States)

    Alci, Bulent

    2015-01-01

    This study aims to determine the predictive and explanatory model in terms of university students' academic performance in "General Chemistry" course and their motivational features. The participants were 169 university students in the 1st grade at university. Of the participants, 132 were female and 37 were male students. Regarding…

  20. Identifying Chronic Conditions and Other Selected Factors That Motivate Physical Activity in World Senior Games Participants and the General Population

    Directory of Open Access Journals (Sweden)

    Ray M. Merrill PhD, MPH

    2015-07-01

    Full Text Available This study assesses chronic disease or disease-related conditions as motivators of physical activity. It also compares these and other motivators of physical activity between Senior Games participants (SGPs and the general population. Analyses are based on an anonymous cross-sectional survey conducted among 666 SGPs and 177 individuals from the general population. SGPs experienced better general health and less obesity, diabetes, and depression, as well as an average of 14.7 more years of regular physical activity (p < .0001, 130.8 more minutes per week of aerobic activity (p < .0001, and 42.7 more minutes of anaerobic activity per week (p < .0001. Among those previously told they had diabetes, high blood pressure, high cholesterol, or depression, 74.2%, 72.2%, 70.4%, and 60.6%, respectively, said that it motivated them to increase their physical activity. Percentages were similar between SGPs and the general population. SGPs were more likely motivated to be physically active to improve physical and mental health in the present, to prevent physical and cognitive decline in the future, and to increase social opportunities. The Senior Games reinforces extrinsic motivators to positively influence intrinsic promoters such as skill development, satisfaction of learning, enjoyment, and fun.

  1. Growth of self-perceived clinical competence in postgraduate training for general practice and its relation to potentially influencing factors.

    NARCIS (Netherlands)

    Kramer, A.W.M.; Zuithoff, P.; Jansen, J.J.M.; Tan, L.H.; Grol, R.P.T.M.; Vleuten, C.P.M. van der

    2007-01-01

    OBJECTIVE: To examine the increase in self-perceived clinical competence during a three-year postgraduate training in general practice and to explore the relation between the growth of self-perceived competence and several background variables. DESIGN: Cohort, 1995-1998. SETTING: Three-year Postgrad

  2. Sexual orientation and health : general and minority stress factors explaining health differences between lesbian, gay, bisexual and heterosexual individuals

    NARCIS (Netherlands)

    Kuyper, L.S.

    2011-01-01

    Previous studies show that lesbian, gay and bisexual (LGB) individuals report more health problems than heterosexual individuals. However, several important gaps remain in the knowledge regarding the explanations for these health differences. In general, there is a lack of differentiation between su

  3. Carpal tunnel syndrome in general practice 1987 and 2001: incidence and the role of occupational and non-occupational factors.

    NARCIS (Netherlands)

    Bongers, F.J.M.; Schellevis, F.G.; Bosch, W.J.H.M. van den; Zee, J. van der

    2007-01-01

    Most studies on the incidence of the carpal tunnel syndrome and the relation of this disorder with occupation are population-based. In this study we present data from general practice. Aim: to compare incidence rates of carpal tunnel syndrome in 1987 and 2001, and to study the relationship between c

  4. A Re-Assessment of Factors Associated with Environmental Concern and Behavior Using the 2010 General Social Survey

    Science.gov (United States)

    Newman, Todd P.; Fernandes, Ronald

    2016-01-01

    The associations between social and psychological influences and environmental attitudes, intentions and behavior have generated considerable interest, both in the fields of environmental behavior and of environmental education. We use the 2010 General Social Survey (GSS) to study these associations and expand the scope of earlier studies by…

  5. The Influence of Self-Efficacy and Motivational Factors on Academic Performance in General Chemistry Course: A Modeling Study

    Science.gov (United States)

    Alci, Bulent

    2015-01-01

    This study aims to determine the predictive and explanatory model in terms of university students' academic performance in "General Chemistry" course and their motivational features. The participants were 169 university students in the 1st grade at university. Of the participants, 132 were female and 37 were male students. Regarding…

  6. General and Maladaptive Traits in a Five-Factor Framework for "DSM"-5 in a University Student Sample

    Science.gov (United States)

    De Fruyt, Filip; De Clercq, Barbara; De Bolle, Marleen; Wille, Bart; Markon, Kristian; Krueger, Robert F.

    2013-01-01

    The relationships between two measures proposed to describe personality pathology, that is the Revised NEO Personality Inventory (NEO-PI-3) and the Personality Inventory for "DSM"-5 (PID-5), are examined in an undergraduate sample (N = 240). The NEO inventories are general trait measures, also considered relevant to assess disordered…

  7. General and Maladaptive Traits in a Five-Factor Framework for "DSM"-5 in a University Student Sample

    Science.gov (United States)

    De Fruyt, Filip; De Clercq, Barbara; De Bolle, Marleen; Wille, Bart; Markon, Kristian; Krueger, Robert F.

    2013-01-01

    The relationships between two measures proposed to describe personality pathology, that is the Revised NEO Personality Inventory (NEO-PI-3) and the Personality Inventory for "DSM"-5 (PID-5), are examined in an undergraduate sample (N = 240). The NEO inventories are general trait measures, also considered relevant to assess disordered…

  8. Affordances and distributed cognition in museum exhibitions

    DEFF Research Database (Denmark)

    Achiam, Marianne; May, Michael; Marandino, Martha

    2014-01-01

    consistent framework. Here, we invoke the notions of affordance and distributed cognition to explain in a coherent way how visitors interact with exhibits and exhibit spaces and make meaning from those interactions, and we exemplify our points using observations of twelve visitors to exhibits at a natural...... history museum. We show how differences in exhibit characteristics give rise to differences in the interpretive strategies used by visitors in their meaning-making process, and conclude by discussing how the notions of affordance and distributed cognition can be used in an exhibit design perspective....

  9. Stroke awareness in the general population: knowledge of stroke risk factors and warning signs in older adults.

    LENUS (Irish Health Repository)

    Hickey, Anne

    2009-01-01

    BACKGROUND: Stroke is a leading cause of death and functional impairment. While older people are particularly vulnerable to stroke, research suggests that they have the poorest awareness of stroke warning signs and risk factors. This study examined knowledge of stroke warning signs and risk factors among community-dwelling older adults. METHODS: Randomly selected community-dwelling older people (aged 65+) in Ireland (n = 2,033; 68% response rate). Participants completed home interviews. Questions assessed knowledge of stroke warning signs and risk factors, and personal risk factors for stroke. RESULTS: Of the overall sample, 6% had previously experienced a stroke or transient ischaemic attack. When asked to identify stroke risk factors from a provided list, less than half of the overall sample identified established risk factors (e.g., smoking, hypercholesterolaemia), hypertension being the only exception (identified by 74%). Similarly, less than half identified established warning signs (e.g., weakness, headache), with slurred speech (54%) as the exception. Overall, there were considerable gaps in awareness with poorest levels evident in those with primary level education only and in those living in Northern Ireland (compared with Republic of Ireland). CONCLUSION: Knowledge deficits in this study suggest that most of the common early symptoms or signs of stroke were recognized as such by less than half of the older adults surveyed. As such, many older adults may not recognise early symptoms of stroke in themselves or others. Thus, they may lose vital time in presenting for medical attention. Lack of public awareness about stroke warning signs and risk factors must be addressed as one important contribution to reducing mortality and morbidity from stroke.

  10. Stroke awareness in the general population: knowledge of stroke risk factors and warning signs in older adults

    Directory of Open Access Journals (Sweden)

    Shelley Emer

    2009-08-01

    Full Text Available Abstract Background Stroke is a leading cause of death and functional impairment. While older people are particularly vulnerable to stroke, research suggests that they have the poorest awareness of stroke warning signs and risk factors. This study examined knowledge of stroke warning signs and risk factors among community-dwelling older adults. Methods Randomly selected community-dwelling older people (aged 65+ in Ireland (n = 2,033; 68% response rate. Participants completed home interviews. Questions assessed knowledge of stroke warning signs and risk factors, and personal risk factors for stroke. Results Of the overall sample, 6% had previously experienced a stroke or transient ischaemic attack. When asked to identify stroke risk factors from a provided list, less than half of the overall sample identified established risk factors (e.g., smoking, hypercholesterolaemia, hypertension being the only exception (identified by 74%. Similarly, less than half identified established warning signs (e.g., weakness, headache, with slurred speech (54% as the exception. Overall, there were considerable gaps in awareness with poorest levels evident in those with primary level education only and in those living in Northern Ireland (compared with Republic of Ireland. Conclusion Knowledge deficits in this study suggest that most of the common early symptoms or signs of stroke were recognized as such by less than half of the older adults surveyed. As such, many older adults may not recognise early symptoms of stroke in themselves or others. Thus, they may lose vital time in presenting for medical attention. Lack of public awareness about stroke warning signs and risk factors must be addressed as one important contribution to reducing mortality and morbidity from stroke.

  11. Educational interventions for general practitioners to identify and manage depression as a suicide risk factor in young people: a systematic review and meta-analysis protocol.

    Science.gov (United States)

    Tait, Lynda; Michail, Maria

    2014-12-15

    Suicide is a major public health problem and globally is the second leading cause of death in young adults. Globally, there are 164,000 suicides per year in young people under 25 years. Depression is a strong risk factor for suicide. Evidence shows that 45% of those completing suicide, including young adults, contact their general practitioner rather than a mental health professional in the month before their death. Further evidence indicates that risk factors or early warning signs of suicide in young people go undetected and untreated by general practitioners. Healthcare-based suicide prevention interventions targeted at general practitioners are designed to increase identification of at-risk young people. The rationale of this type of intervention is that early identification and improved clinical management of at-risk individuals will reduce morbidity and mortality. This systematic review will synthesise evidence on the effectiveness of education interventions for general practitioners in identifying and managing depression as a suicide risk factor in young people. We shall conduct a systematic review and meta-analysis following the Cochrane Handbook for Systematic Reviews of Interventions guidelines and conform to the reporting guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement recommendations. Electronic databases will be systematically searched for randomised controlled trials and quasi-experimental studies investigating the effectiveness of interventions for general practitioners in identifying and managing depression as a suicide risk factor in young people in comparison to any other intervention, no intervention, usual care or waiting list. Grey literature will be searched by screening trial registers. Only studies published in English will be included. No date restrictions will be applied. Two authors will independently screen titles and abstracts of potential studies. The primary outcome is

  12. Factors affecting poor attendance for outpatient physiotherapy by patients discharged from Mthatha General Hospital with a stroke

    OpenAIRE

    N.P. Ntamo; D. Buso; Longo-Mbenza, B

    2013-01-01

    Background: Stroke is a major cause of disability inthe world and its long term effects require adherence to physiotherapyprotocols for optimal rehabilitation. Clinical impression of data fromMthatha General Hospital (MGH) Physiotherapy Department revealedthat there was poor attendance of outpatient physiotherapy by strokepatients discharged from MGH and this had negative effects on outcomesand health care costs.Objective: To determine the extent and the socio-demographic reasonsfor poor atte...

  13. "Do I have to be good all day? The timing of delayed reinforcement as a factor in generalization.

    OpenAIRE

    Fowler, S A; Baer, D M

    1981-01-01

    Delayed reinforcement, sometimes delivered just after the setting in which the critical behavior had occurred (Early), and sometimes delivered only after several further settings had been encountered (Late), was used to improve a variety of behaviors in seven preschool children, and to control their generalization. Performance of those behaviors was measured in two classroom settings: the Contingent setting, within which performance of the specified behavior determined the latter (Early or La...

  14. Endogenous Capital Market Imperfection, Informal Interest Rate Determination and International Factor mobility in a General Equilibrium Model

    OpenAIRE

    Chaudhuri, Sarbajit; GUPTA, Manash Ranjan

    2013-01-01

    This paper makes a pioneering attempt to provide a theory of determination of interest rate in the informal credit market in a less developed economy in terms of a three-sector static deterministic general equilibrium model. There are two informal sectors which obtain production loans from a monopolistic moneylender and employ labour from the informal labour market. On the other hand, the formal sector employs labour at an institutionally fixed wage rate and takes loans from the competitive f...

  15. 48 CFR 6101.17 - Exhibits [Rule 17].

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Exhibits . 6101.17 Section 6101.17 Federal Acquisition Regulations System CIVILIAN BOARD OF CONTRACT APPEALS, GENERAL SERVICES... original by leave of the Board at any time. The Board may require a party to provide either copies...

  16. 7 CFR Exhibit A to Subpart L of... - [Reserved

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true [Reserved] A Exhibit A to Subpart L of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING SERVICE, RURAL BUSINESS...) PROGRAM REGULATIONS (CONTINUED) GENERAL Methodology and Formulas for Allocation of Loan and Grant Program...

  17. Comparison of incidence and risk factors of delirium between general and regional anesthesia in elderly patients after lower extremity surgery

    Directory of Open Access Journals (Sweden)

    ilke Kupeli

    2016-03-01

    Conclusion: We found that the incidence of delirium is 12.5% in elderly patients undergoing total hip or knee arthroplasty and femur fracture surgery. Advanced age and polypharmacy are risk factors of delirium. Delirium increases the hospital stay and cost. [Cukurova Med J 2016; 41(1.000: 34-40

  18. Risk factors for more severe regional musculoskeletal symptoms: a two-year prospective study of a general working population

    DEFF Research Database (Denmark)

    Andersen, JH; Haahr, J. P.; Frost, P.

    2007-01-01

    ,604 workers from industrial and service companies, we collected information on work-related physical and psychosocial exposures and on individual and health-related factors. Questionnaires were completed at baseline by 4,006 participants (71.5%) and after 24 months by 3,276 (82%). At followup, participants...

  19. Screening for congenital malformations by ultrasonography in the general population of pregnant women: factors affecting the efficacy

    DEFF Research Database (Denmark)

    Tabor, Ann; Zdravkovic, Milica Branislava; Perslev, Annette

    2003-01-01

    of the staff were at work. CONCLUSIONS: Some team and work environment factors that may affect the detection rate of fetal abnormalities were identified and have been changed: appointments for screening have been reorganized, regular breaks for all the staff introduced and second opinions are given...

  20. Main causes and factors associated with liver cirrhosis in patients in the General Hospital of Zone 2 of Chiapas, Mexico

    Directory of Open Access Journals (Sweden)

    Carlos Alfredo Meléndez González

    2012-08-01

    Full Text Available Background: Liver cirrhosis is a worldwide public health problem. Its main characteristic is low life expectancy. In Mexico, it is the second leading cause of death in the age group with the highest work productivity. Methods: The study is observational, retrospective, descriptive and cross-sectional. Data were collected on age, sex, occupation, origin, risk factors for liver damage and probable etiology of patients referred with a diagnosis of cirrhosis in a period of 2 years. Purpose: To determine the causes and factors associated with liver cirrhosis in our population. Results: Females prevailed over males by 57.2% over 42.7%. Average age was 55.27 and 55.02% were Tuxtla Gutierrez residents. The following risk factors were found: alcohol consumption (74.67%, diabetes mellitus (56.33%, obesity (41.92%, use of alternative medicines (19.22%, frequent use of drugs (12.66%, and transfusion (9.17%. Housewives were most affected (50.21% [95% CI 43.6-56.9]. Alcoholism in 47.59% was found to be a triggering factor; in 41.92% the cause was unexplained or cryptogenic; and in 5.24% the cause was chronic viral hepatitis. Portal hypertension data were found in 89.5%: 59.8% had esophageal varices, 37.11% had ascites, and 2.62% had chronic hepatic encephalopathy. VP > 11 mm in 18.7%. The prevalence during the study period was 9.85%. Conclusions: There are significant differences observed in gender and cause of cirrhosis in this study. In the future more research should be done to look into the conditions under which women live in the city of Tuxtla Gutierrez, as well as whether other idiosyncratic factors or cultural conditions are leading to a higher prevalence of cirrhosis in this population group in the Southeast of Mexico.

  1. Clinical Assessment of Standard and Generalized Autocalibrating Partially Parallel Acquisition Diffusion Imaging: Effects of Reduction Factor and Spatial Resolution

    Science.gov (United States)

    Andre, J.B.; Zaharchuk, G.; Fischbein, N.J.; Augustin, M.; Skare, S.; Straka, M.; Rosenberg, J.; Lansberg, M.G.; Kemp, S.; Wijman, C.A.C.; Albers, G.W.; Schwartz, N.E.; Bammer, R.

    2012-01-01

    BACKGROUND AND PURPOSE PI improves routine EPI-based DWI by enabling higher spatial resolution and reducing geometric distortion, though it remains unclear which of these is most important. We evaluated the relative contribution of these factors and assessed their ability to increase lesion conspicuity and diagnostic confidence by using a GRAPPA technique. MATERIALS AND METHODS Four separate DWI scans were obtained at 1.5T in 48 patients with independent variation of in-plane spatial resolution (1.88 mm2 versus 1.25 mm2) and/or reduction factor (R = 1 versus R = 3). A neuroradiologist with access to clinical history and additional imaging sequences provided a reference standard diagnosis for each case. Three blinded neuroradiologists assessed scans for abnormalities and also evaluated multiple imaging-quality metrics by using a 5-point ordinal scale. Logistic regression was used to determine the impact of each factor on subjective image quality and confidence. RESULTS Reference standard diagnoses in the patient cohort were acute ischemic stroke (n = 30), ischemic stroke with hemorrhagic conversion (n = 4), intraparenchymal hemorrhage (n = 9), or no acute lesion (n = 5). While readers preferred both a higher reduction factor and a higher spatial resolution, the largest effect was due to an increased reduction factor (odds ratio, 47 ± 16). Small lesions were more confidently discriminated from artifacts on R = 3 images. The diagnosis changed in 5 of 48 scans, always toward the reference standard reading and exclusively for posterior fossa lesions. CONCLUSIONS PI improves DWI primarily by reducing geometric distortion rather than by increasing spatial resolution. This outcome leads to a more accurate and confident diagnosis of small lesions. PMID:22403781

  2. Science, providence, and progress at the Great Exhibition.

    Science.gov (United States)

    Cantor, Geoffrey

    2012-09-01

    The Great Exhibition of 1851 is generally interpreted as a thoroughly secular event that celebrated progress in science, technology, and industry. In contrast to this perception, however, the exhibition was viewed by many contemporaries as a religious event of considerable importance. Although some religious commentators were highly critical of the exhibition and condemned the display of artifacts in the Crystal Palace as giving succor to materialism, others incorporated science and technology into their religious frameworks. Drawing on sermons, tracts, and the religious periodical press, this essay pays close attention to the ways in which science and technology were endowed with providentialist significance and particularly examines the notion of human progress used by a number of Christian writers, especially Congregationalists, who set scientific and technological progress within a teleological religious perspective. This discussion sheds fresh light not only on the Great Exhibition itself but also on the deployment of natural theology in mid-nineteenth-century Britain.

  3. Assessment of child behavior in dental operatory in relation to sociodemographic factors, general anxiety, body mass index and role of multi media distraction

    Directory of Open Access Journals (Sweden)

    Gyanendra Mishra

    2016-01-01

    Full Text Available Background and Objectives: Children and adolescents comprise a group of individuals representing a large variation in size, competence, maturity, personality, temperament and emotions experience, oral health, family background, culture, etc. Furthermore, a growing child is in a constant state of flux as he grows up and actively interacts with the environment. Many factors contribute to the dental behavior of the child. The aim of this study was to evaluate the effect of sociodemographic factors, general anxiety, body mass index (BMI, and role of multimedia on the child behavior (CB in the dental operatory. Materials and Methods: Three hundred and one children aged 3-14 years and their parents participated in the study. In the first visit, the questionnaire was filled by the parent and general examination was done. During the second visit, the required dental procedure was rendered, and the behavior was recorded by a single examiner. Results: Among sociodemographic factors, increasing age is directly related to child′s positive behavior, whereas other factors such as gender and socioeconomic status (SES are not significantly related. General anxiety significantly affects the child′s behavior. BMI of the child is not related to child′s behavior in dental operatory. Multimedia was not found to be significantly affecting the behavior of the child in dental operatory. Interpretations and Conclusion: The principle conclusion of this study is that there is a significant association of age and treatment procedure rendered with the CB in the dental operatory whereas gender, SES, general anxiety, BMI, and multimedia do not show any significant association with the CB in the dental operatory.

  4. The relation between societal factors and different forms of prejudice: A cross-national approach on target-specific and generalized prejudice.

    Science.gov (United States)

    Meeusen, Cecil; Kern, Anna

    2016-01-01

    The goal of this paper was to investigate the generalizability of prejudice across contexts by analyzing associations between different types of prejudice in a cross-national perspective and by investigating the relation between country-specific contextual factors and target-specific prejudices. Relying on the European Social Survey (2008), results indicated that prejudices were indeed positively associated, confirming the existence of a generalized prejudice component. Next to substantial cross-national differences in associational strength, also within country variance in target-specific associations was observed. This suggested that the motivations for prejudice largely vary according to the intergroup context. Two aspects of the intergroup context - economic conditions and cultural values - showed to be related to generalized and target-specific components of prejudice. Future research on prejudice and context should take an integrative approach that considers both the idea of generalized and specific prejudice simultaneously.

  5. Investigating Design Research Landscapes through Exhibition

    DEFF Research Database (Denmark)

    Jönsson, Li; Hansen, Flemming Tvede; Mäkelä, Maarit;

    2013-01-01

    What characterizes a design research exhibition compared to a traditional design and art exhibition? How do you show the very materialities of the design experiments as a means for communicating knowledge of research and of practice? How do you present, review and utilize such an exhibition......? With those questions in mind, the intention and challenge for the Nordes 2013 Design Research Exhibition was to expand on current notions of staging research enquires in design research conference contexts. Artefacts, installations, performances, and other materialities that relate to the theme...... of the conference - Experiments in Design Research – were displayed as tools to express and communicate different design research enquires. Through this paper we will describe the Nordes exhibition as a specific case that renders questions visible in relation to how to utilize a design research exhibition...

  6. The General Assessment of Personality Disorder (GAPD): factor structure, incremental validity of self-pathology, and relations to DSM-IV personality disorders.

    Science.gov (United States)

    Hentschel, Annett G; Livesley, W John

    2013-01-01

    Recent developments in the classification of personality disorder, especially moves toward more dimensional systems, create the need to assess general personality disorder apart from individual differences in personality pathology. The General Assessment of Personality Disorder (GAPD) is a self-report questionnaire designed to evaluate general personality disorder. The measure evaluates 2 major components of disordered personality: self or identity problems and interpersonal dysfunction. This study explores whether there is a single factor reflecting general personality pathology as proposed by the Diagnostic and Statistical Manual of Mental Disorders (5th ed.), whether self-pathology has incremental validity over interpersonal pathology as measured by GAPD, and whether GAPD scales relate significantly to Diagnostic and Statistical Manual of Mental Disorders (4th ed. [DSM-IV]) personality disorders. Based on responses from a German psychiatric sample of 149 participants, parallel analysis yielded a 1-factor model. Self Pathology scales of the GAPD increased the predictive validity of the Interpersonal Pathology scales of the GAPD. The GAPD scales showed a moderate to high correlation for 9 of 12 DSM-IV personality disorders.

  7. Risk factors for malnutrition in children at Port Moresby General Hospital, Papua New Guinea: a case-control study.

    Science.gov (United States)

    Olita'a, Diana; Vince, John; Ripa, Paulus; Tefuarani, Nakapi

    2014-12-01

    Fifty children admitted for malnutrition were age matched with 50 admitted for other reasons. These children were more likely to be female (p = 0.003), born low birth weight (p = 0.02), after a short birth interval (p = 0.014) and to be incompletely vaccinated (p children, and to be living in rural villages or settlement housing (p household income (p = 0.04). Their parents were more likely to have had no or only rudimentary education than parents of control children [Odds ratio (OR) 3.58 for mothers, 4.12 for fathers]. Parental consumption of alcohol as well as smoking in the mother was more common in the malnourished children. Running water in the house was an independent protective factor (OR 0.23) and the fathers' poor employment status (OR 4.12) an independent risk factor. The solution to malnutrition involves improving community understanding of nutrition and in reducing social inequalities.

  8. Carpal tunnel syndrome in general practice (1987 and 2001): incidence and the role of occupational and non-occupational factors

    Science.gov (United States)

    Bongers, Frans JM; Schellevis, Francois G; van den Bosch, Wil JHM; van der Zee, Jouke

    2007-01-01

    Background Most studies on the incidence of the carpal tunnel syndrome and the relation of this disorder with occupation are population-based. In this study we present data from general practice. Aim To compare incidence rates of carpal tunnel syndrome in 1987 with those in 2001, and to study the relationship between carpal tunnel syndrome and occupation. Design of study Analysis of the data of the first and second Dutch National Survey of General Practice, conducted in 1987 and 2001, respectively. Setting General practices in The Netherlands. Method One hundred and three general practices in 1987 with 355 201 listed patients, and 96 practices with 364 998 listed patients in 2001, registered all patients who presented with a new episode of carpal tunnel syndrome. Patient and GP populations were representative for The Netherlands. Results The crude incidence rate was 1.3 per 1000 (95% confidence interval [CI] = 1.0 to 1.5) in 1987, and 1.8 per 1000 (95% CI = 1.7 to 2.0) in 2001. In males it was 0.6 (95% CI = 0.5 to 0.7) and 0.9 (95% CI = 0.8 to 1.0) respectively; in females 1.9 (95% CI = 1.7 to 2.1) and 2.8 (95% CI = 2.6 to 3.1). At both study periods, peak incidence rate occurred in the 45–64-year age group: in 2001 this peak reached 4.8 per 1000 (95 CI = 4.1 to 5.4) for females and 1.6 (95 CI = 1.2 to 2.0) for males. Women who performed unskilled and semi-skilled work had 1.5 times greater risk of acquiring carpal tunnel syndrome than women with higher-skilled jobs (P<0.001). In men no relationship of this kind was found. Conclusion In 2001 the crude incidence rate of carpal tunnel syndrome was 1.5 times higher than in 1987, but the difference was not statistically significant after subdividing by age and sex. In both years the female:male ratio was 3:1. Incidence rates were related to the job level of women, but not of men. PMID:17244422

  9. Use of Weather Information by General Aviation Pilots. Part 2. Qualitative: Exploring Factors Involved in Weather-Related Decision Making

    Science.gov (United States)

    2008-03-01

    fic nstances wthn some gven text, speech, or behavor (Mles & Huberman , 1994). Multple nstances of a sngle factor then consttute a “theme...Aerospace Medcne. Mles, M.B., and Huberman , A.M. (1994). Qualitative data analysis. Thousand Oaks, CA: Sage. Mlgram, S. (2004). Obedience to authority...personal minimum for GA VFR visibility ________ statute miles 12. Your normal personal minimum for GA VFR cloud ceiling ________ feet AGL For

  10. Waves in geomaterials exhibiting negative stiffness behaviour

    Science.gov (United States)

    Esin, Maxim; Dyskin, Arcady; Pasternak, Elena

    2016-04-01

    Negative stiffness denotes the type of material behaviour when the force applied to the body decreases the body's deformation increases. Some geomaterials, for instance, rocks, demonstrate behaviour of this type at certain loads: during the compression tests the loading curves exhibit descending branch (post-peak softening). One of the possible mechanisms of the negative stiffness appearance in geomaterials is rotation of non-spherical grains. It is important to emphasize that in this case the descending branch may be reversible given that the testing machine is stiff enough (in general case it means an importance of boundary conditions). Existence of geomaterials with a negative modulus associated with rotations may have significant importance. In particular, important is understanding of the wave propagation in such materials. We study the stability of geomaterials with negative stiffness inclusions and wave propagation in it using two approaches: Cosserat continuum and discrete mass-spring models. In both cases we consider the rotational degrees of freedom in addition to the conventional translational ones. We show that despite non positiveness of the energy the materials with negative stiffness elements can be stable if certain conditions are met. In the case of Cosserat continuum the Cosserat shear modulus (the modulus relating the non-symmetrical part of shear stress and internal rotations) is allowed to assume negative values as long as its value does not exceed the value of the standard (positive) shear modulus. In the case of discrete mass-spring systems (with translational and rotational springs) the concentration of negative stiffness springs and the absolute values of negative spring stiffness are limited. The critical concentration when the system loses stability and the amplitude of the oscillations tends to infinity is equal to 1/2 and 3/5 for two- and three-dimensional cases respectively.

  11. Seroprevalence and Risk Factors for Hepatitis C Virus Infection among General Population in Central Region of Yemen

    Science.gov (United States)

    Gacche, Rajesh N.; Al-Mohani, Sadiq K.

    2012-01-01

    Background. Hepatitis C virus (HCV) represents a major worldwide public health problem. Though several studies from Yemen have provided an estimate of the prevalence of this viral infection, there exist only few studies which reflect the status in the general population. Aim. The present study was designed to investigate the prevalence of hepatitis C infection among general population in central region of Yemen. Methods. The study population comprised 2,379 apparently healthy subjects who were screened for hepatitis C antibodies (HCV Abs) status using ELISA quantitative technique. Seroprevalence rate of seropositive subjects was calculated and stratified by age, sex, educational level, and monthly income. Results. The study showed that out of 2,379 subjects, 31 (1.3%) were HCV Abs positive. Higher prevalence of HCV Abs was found among females, 24 (1.01%), than males, 7 (0.29%). The age specific prevalence rose from 00 (0.00%) in subjects aged ≤14 years to a maximum of 9 (0.38%) in subjects aged ≥55 years. The prevalence of HCV Abs was more prevalent in illiterate subjects and increased with decreasing monthly income. Conclusion. It was found that variables including age and educational level were significantly associated with HCV Ab positivity and not associated with gender and monthly income. PMID:23320156

  12. A cross-sectional study of self-reported general health, lifestyle factors, and disease: the Hordaland Health Study

    Directory of Open Access Journals (Sweden)

    Randi Jepsen

    2014-10-01

    Full Text Available Background. Information on self-reported health is important for health professionals, and the aim of this study was to examine associations between lifestyle factors and self-reported health and the mediating effect of disease in a Norwegian population.Methods and Materials. The data collection was conducted as part of the Hordaland Health Study (HUSK 1997–99, which was a cross-sectional epidemiological study. All individuals in Hordaland county born in 1953–1957 were invited to participate (aged 40–44 years. Complete information for the present study was obtained from 12,883 individuals (44% response rate. Height and weight were measured at a physical examination. Information on lifestyle factors, self-reported health, disease (heart attack, apoplexy, angina pectoris, and diabetes, and socio-demographic variables was obtained from a self-administered questionnaire. Self-reported health was measured with a one-item question. Odds ratios for fair or poor self-reported health were calculated using multiple logistic regression analyses adjusted for disease and socio-demographic variables.Results. Respondents reporting adverse lifestyle behaviours (obesity (odds ratio (OR 1.7, p < 0.001, smoking (OR 1.2, p < 0.001, or excessive intake of alcohol (OR 3.3, p < 0.001 showed an increased risk of poor self-reported health. Furthermore, a moderate intake of wine (OR 0.6, p < 0.001 or strenuous physical activity (OR 0.5, p < 0.001 decreased the risk of poor health. Disease did not mediate the effect.Conclusion. A one-item question measuring self-reported health may be a suitable measure for health professionals to identify levels of subjective health and reveal a need to target lifestyle factors in relatively young individuals with or without disease.

  13. Screening for congenital malformations by ultrasonography in the general population of pregnant women: factors affecting the efficacy

    DEFF Research Database (Denmark)

    Tabor, Ann; Zdravkovic, Milica Branislava; Perslev, Annette

    2003-01-01

    malformations were detected in 100 fetuses or infants, corresponding to an incidence of 1.3%. The prenatal DR was 60%. High maternal body mass index (BMI) was associated with a lower DR, while the presence of twins, the gestational age at time of screening and the sonographer's level of experience were not...... of the staff were at work. CONCLUSIONS: Some team and work environment factors that may affect the detection rate of fetal abnormalities were identified and have been changed: appointments for screening have been reorganized, regular breaks for all the staff introduced and second opinions are given...

  14. Factors prompting PSA-testing of asymptomatic men in a country with no guidelines: a national survey of general practitioners.

    LENUS (Irish Health Repository)

    Drummond, Frances J

    2009-01-01

    BACKGROUND: Increased use of prostate specific antigen (PSA) has been associated with increased prostate cancer incidence. Ireland is estimated to have one of the highest prostate cancer incidences in Europe and has no national guidelines for prostate cancer screening. GPs have a pivotal role in influencing PSA testing, therefore, our aim was to describe GP testing practices and to identify factors influencing these. METHODS: A postal survey, including questions on clinical practice and experience, knowledge and demographics was distributed to all GPs (n = 3,683). The main outcomes were (i) PSA testing asymptomatic men and (ii) "inappropriate" PSA testing, defined as testing asymptomatic men aged < 50 or > 75 years. Factors associated with these outcomes were identified using logistic regression. RESULTS: 1,625 GPs responded (response rate corrected for eligibility = 53%). Most respondents (79%) would PSA test asymptomatic men. Of these, 34% and 51% would test asymptomatic men < 50 and > 75 years, respectively. In multivariate analyses, GPs were more likely to test asymptomatic men if they were >or= 50 years, in practice >or= 10 years, female or less knowledgeable about PSA efficacy. Male GPs who would have a PSA test themselves were > 8-times more likely to PSA test asymptomatic men than GPs who would not have a test. GPs who had an asymptomatic patient diagnosed with prostate cancer following PSA testing, were > 3-times more likely to test asymptomatic men. Practice-related factors positively associated with testing included: running \\'well man\\' clinics, performing occupational health checks and performing other tests routinely with PSA. Factors positively associated with \\'inappropriate\\' testing included; being male and willing to have a PSA test, having worked\\/trained in the UK and supporting annual PSA testing. 91% of respondents supported the development of national PSA testing guidelines. CONCLUSION: Our findings suggest that widespread PSA testing

  15. General practitioners' self-perceived ability to recognize severity of common mental disorders: an underestimated factor in case identification?

    Directory of Open Access Journals (Sweden)

    Mykletun Arnstein

    2006-08-01

    Full Text Available Abstract Background Several studies have shown that general practitioners (GPs under-diagnose common mental disorders, and that training courses hardly improve this practice. The influence of GPs' self-perceived ability to recognize the severity of such disorders on these facts has not been investigated. This study explores: 1 GPs' perceived ability to recognize major depressive episode (MDE and generalized anxiety disorder (GAD in their patients; 2 The GPs' observed ability to recognize severity of these disorders; and 3 If the observed ability to recognize severity is associated with their perceived ability. Methods In a cross-sectional design 40 Norwegian GPs examined 15 – 28 patients each (total N = 724. The GPs' rated their perceived ability to recognize MDE and GAD on a four-point Likert-scale. The GPs' observed ability to recognize severity was defined as the mean of the correlations between the GPs rating of Clinical Global Impression-Severity Scale and the diagnostic reference standards for MDE and GAD filled in by patients. Results Twenty-two GPs considered their perceived ability to recognize MDE as rather good, and the other 18 as moderate/bad. For GAD 12 GPs' perceived their ability as rather good, while 28 considered their ability to be moderate/bad. The observed ability to recognize severity concerning MDE was 0.63 and concerning GAD 0.45. There was no significant association between GPs' perceived and observed abilities to recognize MDE (p = 0.19 and GAD (p = 0.34 Conclusion This study found a discrepancy between the GPs' perceived and observed ability to recognize common mental disorders. The lack of association between GPs' perceived and observed ability to recognize such disorders indicate low understanding of own recognition abilities. This might contribute to explain the low effectiveness of interventions aimed to increase GPs' abilities to recognize mental disorders.

  16. Artefacts and the performance of an exhibition

    DEFF Research Database (Denmark)

    Svabo, Connie

    2008-01-01

    The article explores the role of mediating artefacts in children's encounters with a museum of natural history. Using actor network theory it explores how a specific artefact shapes the way users relate to exhibited objects and how the artefact guides users' movements in the exhibition. The media...

  17. Encountering Nanotechnology in an Interactive Exhibition

    Science.gov (United States)

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  18. Exhibition Economy Set to Boost City Development

    Institute of Scientific and Technical Information of China (English)

    Li Zhen

    2010-01-01

    @@ Awell-developed exhibition industry is usually regarded as an important cri terion in measuring a city's economic and social development level. In recent years, much attention has been paid to exhibition economy for its positive effect on dining, transportation, tourism, advertising, and shopping.

  19. Encountering Nanotechnology in an Interactive Exhibition

    Science.gov (United States)

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  20. Comparison of CAD risk factors in abdominal obesity versus general obesity with normal WC in adult males.

    Science.gov (United States)

    Kamran, Sultan Mehmood; Iftikhar, Raheel; Khan, Amjad; Altaf, Muhammad

    2014-04-01

    To compare the presence of coronary artery disease risk factors in patients with abdominal obesity versus generalised obesity and to determine the probability of developing the disease in both groups. The cross-sectional study was carried out at the Department of Medicine, Combined Military Hospital, Okara, from January 2012 to April 2013. Using consecutive sampling, 785 outdoor healthy adult males were enrolled. Body mass index > 25kg/m2 and waist circumference > 90cm defined obesity and abdominal obesity respectively. Blood pressure > 140/90mmHg defined Hypertension. All the subjects underwent BSF, electrocardiogram, Lipid profile, personality and physical activity assessment. Risk estimation was done using Eric Brittain scoring system. Data was analysed using SPSS 16. In patients with abdominal obesity, 583 (99.2%) individuals had at least 1 risk factor for coronary artery disease, while in those with generalised obesity this prevalence was 96.5% (n = 191). In patients with abdominal obesity, 52.9% had more than 4% risk of developing the disease in the next 6 years compared to 36.9% individuals with generalised obesity. Both increasing body mass index and waist circumference are associated with increased risk of developing coronary artery disease, with significantly higher risk prevalence in the latter group. Moreover, those with abdominal obesity had a higher risk of developing CAD in next 6 years as compared to those with generalised obesity. Thus waist circumference offers additional prognostic information beyond body mass index.