WorldWideScience

Sample records for factors fourth edition

  1. Factor Structure of the Wechsler Intelligence Scale for Children--Fourth Edition among Referred Students

    Science.gov (United States)

    Watkins, Marley W.; Wilson, Sharise M.; Kotz, Kasey M.; Carbone, Maria C.; Babula, Teresa

    2006-01-01

    Factor analysis was applied to the Wechsler Intelligence Scale for Children--Fourth Edition (WISC-IV) scores of 432 Pennsylvania students referred for evaluation for special education services to determine the factor structure of the WISC-IV with this population. A first-order, four-factor oblique solution that mirrored that found in the WISC-IV…

  2. Factor Structure of the Wechsler Intelligence Scale for Children: Fourth Edition in Children with ADHD.

    Science.gov (United States)

    Thaler, Nicholas S; Barchard, Kimberly A; Parke, Elyse; Jones, W Paul; Etcoff, Lewis M; Allen, Daniel N

    2015-12-01

    Recent evidence suggests that the factor structure of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) is better explained by a five-factor model rather than the four-factor model in the standardization sample. The current study examined the WISC-IV's factor structure in a sample of children with ADHD. Participants included 314 children and adolescents who were diagnosed with ADHD. Confirmatory factor analysis was conducted on the 10 core subtests of the WISC-IV, and three models were examined including two based on Cattell-Horn-Carroll (CHC) theory. A five-factor model consisting of Gc, Gf, Gv, Gsm, and Gs factors provided the best fit for the data. The Perceptual Reasoning factor identified in the original four-factor model split into the two CHC factors, Gf and Gv, and cross-loaded the Symbol Search subtest onto the Gv factor. A five-factor model based on CHC theory provided superior fit for the WISC-IV in children with ADHD, as has been found with the standardization sample. © The Author(s) 2012.

  3. Confirmatory Factor Analysis of the Dutch Version of the Wechsler Memory Scale-Fourth Edition (WMS-IV-NL)

    NARCIS (Netherlands)

    Bouman, Z.; Hendriks, M.P.; Kerkmeer, M.C.; Kessels, R.P.C.; Aldenkamp, A.P.

    2015-01-01

    The latent factor structure of the Dutch version of the Wechsler Memory Scale-Fourth Edition (WMS-IV-NL) was examined with a series of confirmatory factor analyses. As part of the Dutch standardization, 1,188 healthy participants completed the WMS-IV-NL. Four models were tested for the Adult Battery

  4. Confirmatory factor analysis of the Dutch version of the Wechsler Memory Scale-Fourth Edition (WMS-IV-NL)

    NARCIS (Netherlands)

    Bouman, Z.; Hendriks, M.P.H.; Kerkmeer, M.; Kessels, R.P.C.; Aldenkamp, A.P.

    2015-01-01

    The latent factor structure of the Dutch version of the Wechsler Memory Scale-Fourth Edition (WMS-IV-NL) was examined with a series of confirmatory factor analyses. As part of the Dutch standardization, 1,188 healthy participants completed the WMS-IV-NL. Four models were tested for the Adult Battery

  5. Investigation of the Factor Structure of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): Exploratory and Higher Order Factor Analyses

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.

    2010-01-01

    The present study examined the factor structure of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV; D. Wechsler, 2008a) standardization sample using exploratory factor analysis, multiple factor extraction criteria, and higher order exploratory factor analysis (J. Schmid & J. M. Leiman, 1957) not included in the WAIS-IV Technical…

  6. Investigation of the Factor Structure of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): Exploratory and Higher Order Factor Analyses

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.

    2010-01-01

    The present study examined the factor structure of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV; D. Wechsler, 2008a) standardization sample using exploratory factor analysis, multiple factor extraction criteria, and higher order exploratory factor analysis (J. Schmid & J. M. Leiman, 1957) not included in the WAIS-IV Technical…

  7. Confirmatory Factor Analysis of the Dutch Version of the Wechsler Memory Scale-Fourth Edition (WMS-IV-NL).

    Science.gov (United States)

    Bouman, Zita; Hendriks, Marc P H; Kerkmeer, Margreet C; Kessels, Roy P C; Aldenkamp, Albert P

    2015-05-01

    The latent factor structure of the Dutch version of the Wechsler Memory Scale-Fourth Edition (WMS-IV-NL) was examined with a series of confirmatory factor analyses. As part of the Dutch standardization, 1,188 healthy participants completed the WMS-IV-NL. Four models were tested for the Adult Battery (16-69 years; N = 699), and two models were tested for the Older Adult Battery (65-90 years; N = 489). Results corroborated the presence of three WMS-IV-NL factors in the Adult Battery consisting of Auditory Memory, Visual Memory, and Visual Working Memory. A two-factor model (consisting of Auditory Memory and Visual Memory) provided the best fit for the data of the Older Adult Battery. These findings provide evidence for the structural validity of the WMS-IV-NL, and further support the psychometric integrity of the WMS-IV.

  8. Exploratory and Higher-Order Factor Analyses of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) Adolescent Subsample

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.

    2010-01-01

    The factor structure of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV; Wechsler, 2008a) with the adolescent participants (ages 16-19 years; N = 400) in the standardization sample was assessed using exploratory factor analysis, multiple factor extraction criteria, and higher-order exploratory factor analyses. Results from…

  9. Exploratory and Higher-Order Factor Analyses of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) Adolescent Subsample

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.

    2010-01-01

    The factor structure of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV; Wechsler, 2008a) with the adolescent participants (ages 16-19 years; N = 400) in the standardization sample was assessed using exploratory factor analysis, multiple factor extraction criteria, and higher-order exploratory factor analyses. Results from…

  10. Higher Order, Multisample, Confirmatory Factor Analysis of the Wechsler Intelligence Scale for Children--Fourth Edition: What Does It Measure?

    Science.gov (United States)

    Keith, Timothy Z.; Fine, Jodene Goldenring; Taub, Gordon E.; Reynolds, Matthew R.; Kranzler, John H.

    2006-01-01

    The recently published fourth edition of the Wechsler Intelligence Scale for Children (WISC-IV) represents a considerable departure from previous versions of the scale. The structure of the instrument has changed, and some subtests have been added and others deleted. The technical manual for the WISC-IV provided evidence supporting this new…

  11. Factor Structure of the Wechsler Intelligence Scales for Children-Fourth Edition among Referred Native American Students

    Science.gov (United States)

    Nakano, Selena; Watkins, Marley W.

    2013-01-01

    The Native American population is severely underrepresented in empirical test validity research despite being overrepresented in special education programs and at increased risk for psychoeducational evaluation. The structural validity of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) was investigated with a sample of 176,…

  12. Factor Structure of the Wechsler Intelligence Scales for Children-Fourth Edition among Referred Native American Students

    Science.gov (United States)

    Nakano, Selena; Watkins, Marley W.

    2013-01-01

    The Native American population is severely underrepresented in empirical test validity research despite being overrepresented in special education programs and at increased risk for psychoeducational evaluation. The structural validity of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) was investigated with a sample of 176,…

  13. Investigation of the factor structure of the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV): exploratory and higher order factor analyses.

    Science.gov (United States)

    Canivez, Gary L; Watkins, Marley W

    2010-12-01

    The present study examined the factor structure of the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV; D. Wechsler, 2008a) standardization sample using exploratory factor analysis, multiple factor extraction criteria, and higher order exploratory factor analysis (J. Schmid & J. M. Leiman, 1957) not included in the WAIS-IV Technical and Interpretation Manual (D. Wechsler, 2008b). Results indicated that the WAIS-IV subtests were properly associated with the theoretically proposed first-order factors, but all but one factor-extraction criterion recommended extraction of one or two factors. Hierarchical exploratory analyses with the Schmid and Leiman procedure found that the second-order g factor accounted for large portions of total and common variance, whereas the four first-order factors accounted for small portions of total and common variance. It was concluded that the WAIS-IV provides strong measurement of general intelligence, and clinical interpretation should be primarily at that level.

  14. Fuel Cell Handbook, Fourth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Stauffer, D.B; Hirschenhofer, J.H.; Klett, M.G.; Engleman, R.R.

    1998-11-01

    Robust progress has been made in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in January 1994. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultra high efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 6 describe the four major fuel cell types and their performance based on cell operating conditions. The section on polymer electrolyte membrane fuel cells has been added to reflect their emergence as a significant fuel cell technology. Phosphoric acid, molten carbonate, and solid oxide fuel cell technology description sections have been updated from the previous edition. New information indicates that manufacturers have stayed with proven cell designs, focusing instead on advancing the system surrounding the fuel cell to lower life cycle costs. Section 7, Fuel Cell Systems, has been significantly revised to characterize near-term and next-generation fuel cell power plant systems at a conceptual level of detail. Section 8 provides examples of practical fuel cell system calculations. A list of fuel cell URLs is included in the Appendix. A new index assists the reader in locating specific information quickly.

  15. An examination of the factor structure of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, narcissistic personality disorder criteria: one or two factors?

    Science.gov (United States)

    Miller, Joshua D; Hoffman, Brian J; Campbell, W Keith; Pilkonis, Paul A

    2008-01-01

    A growing body of research has suggested that narcissistic personality disorder (NPD) contains 2 factors or types: overt/grandiose and covert/vulnerable. A recent factor analysis of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), NPD symptoms supported a similar 2-factor model. The present research tested this proposed 2-factor solution against a 1-factor solution (N = 289; 72% patients) using both confirmatory factor analysis and an examination of associations between the resultant factors and theoretically relevant criteria (other personality disorders; depression, anxiety). The results of the confirmatory factor analysis supported a 1-factor solution. Likewise, the 2 factors each yielded a similar pattern of correlations with relevant criteria. Together, these results argue against a 2-factor structure for the current DSM-IV NPD symptoms. Given the broader research literature suggesting a 2-factor structure of narcissism, strategies for assessing both overt/grandiose and covert/vulnerable forms of narcissism in DSM-V are discussed.

  16. Human Resources Administration: A School-Based Perspective. Fourth Edition

    Science.gov (United States)

    Smith, Richard

    2009-01-01

    Enhanced and updated, this Fourth Edition of Richard E. Smith's highly successful text examines the growing role of the principal in planning, hiring, staff development, supervision, and other human resource functions. The Fourth Edition includes new sections on ethics, induction, and the role of the mentor teacher. This edition also introduces…

  17. Human Resources Administration: A School-Based Perspective. Fourth Edition

    Science.gov (United States)

    Smith, Richard

    2009-01-01

    Enhanced and updated, this Fourth Edition of Richard E. Smith's highly successful text examines the growing role of the principal in planning, hiring, staff development, supervision, and other human resource functions. The Fourth Edition includes new sections on ethics, induction, and the role of the mentor teacher. This edition also introduces…

  18. An independent confirmatory factor analysis of the Wechsler Intelligence Scale for Children-fourth Edition (WISC-IV) integrated: what do the process approach subtests measure?

    Science.gov (United States)

    Benson, Nicholas; Hulac, David M; Bernstein, Joshua D

    2013-09-01

    The Wechsler intelligence scale for children--fourth edition (WISC-IV) Integrated contains the WISC-IV core and supplemental subtests along with process approach subtests designed to facilitate a process-oriented approach to score interpretation. The purpose of this study was to examine the extent to which WISC-IV Integrated subtests measure the constructs they are purported to measure. In addition to examining the measurement and scoring model provided in the manual, this study also tested hypotheses regarding Cattell-Horn-Carroll abilities that might be measured along with other substantive questions regarding the factor structure of the WISC-IV Integrated and the nature of abilities measured by process approach subtests. Results provide insight regarding the constructs measured by these subtests. Many subtests appear to be good to excellent measures of psychometric g (i.e., the general factor presumed to cause the positive correlation of mental tasks). Other abilities measured by subtests are described. For some subtests, the majority of variance is not accounted for by theoretical constructs included in the scoring model. Modifications made to remove demands such as memory recall and verbal expression were found to reduce construct-irrelevant variance. The WISC-IV Integrated subtests appear to measure similar constructs across ages 6-16, although strict factorial invariance was not supported.

  19. Dental Hygiene Program Clinic Manual, Fall 1997. Fourth Edition.

    Science.gov (United States)

    Errico, Mary; Cama, Christine; Pastoriza-Maldonado, Alida

    This is the fourth edition of the Clinic Manual for the Dental Hygiene Program at Eugenio Maria de Hostos Community College in the Bronx (New York). It contains general information, grading procedures, performance guides, and clinical forms related to the program. Section 1 provides an introduction to clinic philosophy, policies, goals and…

  20. The Copyright Book: A Practical Guide. Fourth Edition.

    Science.gov (United States)

    Strong, William S.

    In response to important changes in copyright law as the United States accommodates itself to the Berne Convention and develops means to take account of new technologies, this guide puts these changes in a form and context that will make sense to persons who are concerned about their rights under the law. New material in the fourth edition of this…

  1. Power Technologies Energy Data Book - Fourth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Aabakken, J.

    2006-08-01

    This report, prepared by NREL's Strategic Energy Analysis Center, includes up-to-date information on power technologies, including complete technology profiles. The data book also contains charts on electricity restructuring, power technology forecasts, electricity supply, electricity capability, electricity generation, electricity demand, prices, economic indicators, environmental indicators, and conversion factors.

  2. EIA publication manual: Fourth edition. [Energy information manuals

    Energy Technology Data Exchange (ETDEWEB)

    Neef, C.A.

    1988-01-01

    This is the fourth edition of the Publications Manual. It was written to help the staff of the Energy Information Administration (EIA) who are involved in the production process to create and format uniform publications that not only provide information, but readily identify the agency. The manual reflects the substantial changes that have taken place to streamline methods of producing EIA publications over the past few years. Whereas the first edition, in 1979, was written for writers and typists which struggled with producing reports on manual typewriters, this report now reflects the increased use of automation in preparing most EIA publications. EIA has a fully automated photocomposition publishing system. Many of the style features discussed in this manual are automatically produced using EPIC/ICEF2. The need for format sheets and illustrations produced by graphic artists has been significantly reduced. However, the basic style has changed very little. EIA style continues to be based on the Government Printing Office Style Manual with some deviations tailored specifically for EIA.

  3. The effects of Wechsler Intelligence Scale for Children-Fourth Edition cognitive abilities on math achievement.

    Science.gov (United States)

    Parkin, Jason R; Beaujean, A Alexander

    2012-02-01

    This study used structural equation modeling to examine the effect of Stratum III (i.e., general intelligence) and Stratum II (i.e., Comprehension-Knowledge, Fluid Reasoning, Short-Term Memory, Processing Speed, and Visual Processing) factors of the Cattell-Horn-Carroll (CHC) cognitive abilities, as operationalized by the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV; Wechsler, 2003a) subtests, on Quantitative Knowledge, as operationalized by the Wechsler Individual Achievement Test, Second Edition (WIAT-II; Wechsler, 2002) subtests. Participants came from the WISC-IV/WIAT-II linking sample (n=550). We compared models that predicted Quantitative Knowledge using only Stratum III factors, only Stratum II factors, and both Stratum III and Stratum II factors. Results indicated that the model with only the Stratum III factor predicting Quantitative Knowledge best fit the data.

  4. Book review of “The Biomedical Engineering Handbook” fourth edition, edited by Joseph D. Bronzino, Donald R. Peterson

    OpenAIRE

    Koprowski, Robert

    2016-01-01

    This article is a review of the book “The biomedical engineering handbook”, fourth edition: four volume set (ISBN 9781439825334, 254GBP, 5430 pages) edited by Joseph D. Bronzino and Donald R. Peterson published by the CRC Press Taylor & Francis group in 2015. The content of the book and its importance for biomedical engineering have been discussed in this invited review.

  5. Structure of the Wechsler Intelligence Scale for Children-Fourth Edition among a National Sample of Referred Students

    Science.gov (United States)

    Watkins, Marley W.

    2010-01-01

    The structure of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV; D. Wechsler, 2003a) was analyzed via confirmatory factor analysis among a national sample of 355 students referred for psychoeducational evaluation by 93 school psychologists from 35 states. The structure of the WISC-IV core battery was best represented by four…

  6. Validating the Learning Disability Screening Questionnaire against the Weschler Adult Intelligence Scale, Fourth Edition

    Science.gov (United States)

    McKenzie, Karen; Sharples, Phil; Murray, Aja L.

    2015-01-01

    The Learning Disability Screening Questionnaire (LDSQ), a brief screening tool for intellectual disability, was originally validated against the Weschler Adult Intelligence Scale, Third Edition (WAIS-III), which was superseded by the Weschler Adult Intelligence Scale, Fourth Edition (WAIS-IV) in the United Kingdom in 2010. This study examines the…

  7. Validating the Learning Disability Screening Questionnaire against the Weschler Adult Intelligence Scale, Fourth Edition

    Science.gov (United States)

    McKenzie, Karen; Sharples, Phil; Murray, Aja L.

    2015-01-01

    The Learning Disability Screening Questionnaire (LDSQ), a brief screening tool for intellectual disability, was originally validated against the Weschler Adult Intelligence Scale, Third Edition (WAIS-III), which was superseded by the Weschler Adult Intelligence Scale, Fourth Edition (WAIS-IV) in the United Kingdom in 2010. This study examines the…

  8. Weeding Library Collections: Library Weeding Methods. Fourth Edition.

    Science.gov (United States)

    Slote, Stanly J.

    Weeding is one of the best ways to make long-term improvements to library collections, but it is also a difficult and sometimes painful task. In the tradition of previous editions, this book guides librarians in the process of methodical and efficient weeding. The book shows how to identify core collections versus the weedable items. The approach…

  9. Clinical utility of the Wechsler Adult Intelligence Scale-Fourth Edition after traumatic brain injury.

    Science.gov (United States)

    Donders, Jacobus; Strong, Carrie-Ann H

    2015-02-01

    The performance of 100 patients with traumatic brain injury (TBI) on the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) was compared with that of 100 demographically matched neurologically healthy controls. Processing Speed was the only WAIS-IV factor index that was able to discriminate between persons with moderate-severe TBI on the one hand and persons with either less severe TBI or neurologically healthy controls on the other hand. The Processing Speed index also had acceptable sensitivity and specificity when differentiating between patients with TBI who either did or did not have scores in the clinically significant range on the Trail Making Test. It is concluded that WAIS-IV Processing Speed has acceptable clinical utility in the evaluation of patients with moderate-severe TBI but that it should be supplemented with other measures to assure sufficient accuracy in the diagnostic process. © The Author(s) 2014.

  10. The fourth edition of the ASP took place in Kigali

    CERN Multimedia

    CERN Bulletin

    2016-01-01

    The fourth biennial African School of Fundamental Physics and Applications (ASP) took place on 1-19 August in Africa’s cleanest city, Kigali in Rwanda.   The students of the fourth African School of Fundamental Physics and Applications pose for the traditional conference group picture. Many lecturers flew in from CERN to give lectures and mentor students. (Photo: Gilbert Tekoute) Seventy-five students from around the African continent, chosen from 439 applicants, were hosted in the University of Rwanda’s College of Sciences and Technology for about 3 weeks. The school received financial support from CERN and 19 other institutions in total, including the International Centre for Theoretical Physics (ICTP), Brookhaven National Laboratory, the South African National Research Foundation and Department of Technology, the Rwandan Ministry of Education, INFN, and other major particle physics laboratories, as well as governmental institutions in Africa, Europe and the United States....

  11. Indicators of suboptimal performance embedded in the Wechsler Memory Scale-Fourth Edition (WMS-IV)

    NARCIS (Netherlands)

    Bouman, Z.; Hendriks, M.P.H.; Schmand, B.A.; Kessels, R.P.C.; Aldenkamp, A.P.

    2016-01-01

    Introduction. Recognition and visual working memory tasks from the Wechsler Memory Scale-Fourth Edition (WMS-IV) have previously been documented as useful indicators for suboptimal performance. The present study examined the clinical utility of the Dutch version of the WMS-IV (WMS-IV-NL) for the ide

  12. Indicators of suboptimal performance embedded in the Wechsler Memory Scale-Fourth Edition (WMS-IV)

    NARCIS (Netherlands)

    Bouman, Z.; Hendriks, M.P.H; Schmand, B.A.; Kessels, R.P.C.; Aldenkamp, A.P.

    2016-01-01

    INTRODUCTION: Recognition and visual working memory tasks from the Wechsler Memory Scale-Fourth Edition (WMS-IV) have previously been documented as useful indicators for suboptimal performance. The present study examined the clinical utility of the Dutch version of the WMS-IV (WMS-IV-NL) for the

  13. Indicators of suboptimal performance embedded in the Wechsler Memory Scale-Fourth Edition (WMS-IV)

    NARCIS (Netherlands)

    Bouman, Z.; Hendriks, M.P.H.; Schmand, B.A.; Kessels, R.P.C.; Aldenkamp, A.P.

    2016-01-01

    Introduction. Recognition and visual working memory tasks from the Wechsler Memory Scale-Fourth Edition (WMS-IV) have previously been documented as useful indicators for suboptimal performance. The present study examined the clinical utility of the Dutch version of the WMS-IV (WMS-IV-NL) for the

  14. Indicators of suboptimal performance embedded in the Wechsler Memory Scale : Fourth Edition (WMS-IV)

    NARCIS (Netherlands)

    Bouman, Z.; Hendriks, M.P.H.; Schmand, B.A.; Kessels, R.P.C.; Aldenkamp, A.P.

    2016-01-01

    INTRODUCTION: Recognition and visual working memory tasks from the Wechsler Memory Scale-Fourth Edition (WMS-IV) have previously been documented as useful indicators for suboptimal performance. The present study examined the clinical utility of the Dutch version of the WMS-IV (WMS-IV-NL) for the

  15. External validity of the Indonesian Wechsler Adult Intelligence Scale - Fourth edition (WAIS-IV-ID)

    NARCIS (Netherlands)

    Suwartono, C.; Hidajat, L.L.; Halim, M.S.; Hendriks, M.P.H.; Kessels, R.P.C.

    2016-01-01

    The Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV-ID) has been adapted and proved to be valid for its internal structure for Indonesian population. The same structure found as in the American WAIS-IV (WAIS-IV-US; Suwartono, Hendriks, Hidajat, Halim, & Kessels, 2015). Despite its strong i

  16. Longitudinal Invariance of the Wechsler Intelligence Scale for Children--Fourth Edition in a Referral Sample

    Science.gov (United States)

    Richerson, Lindsay P.; Watkins, Marley W.; Beaujean, A. Alexander

    2014-01-01

    Measurement invariance of the Wechsler Intelligence Scale for Children--Fourth Edition (WISC-IV) was investigated with a group of 352 students eligible for psychoeducational evaluations tested, on average, 2.8 years apart. Configural, metric, and scalar invariance were found. However, the error variance of the Coding subtest was not constant…

  17. Test Review: Wechsler Preschool and Primary Scale of Intelligence, Fourth Edition: Canadian

    Science.gov (United States)

    Soares, Melissa A.; McCrimmon, Adam W.

    2013-01-01

    The Wechsler Preschool and Primary Scale of Intelligence-Fourth Edition: Canadian (WPPSI-IVCDN; Wechsler, 2012), published by NCS Pearson, is a newly updated, individually administered measure of cognitive intelligence for children aged 2:6 through 7:7. Suitable for educational, clinical, and research settings, the purposes of the WPPSI-IVCDN are…

  18. European Sourcebook of Crime and Criminal Justice Statistics - 2010 : Fourth edition

    NARCIS (Netherlands)

    Aebi, M.F.; Aubusson de Cavarlay, B.; Barclay, G.; Gruszczyńska, B.; Harrendorf, S.; Heiskanen, M.; Vasilika, H.; Jaquier, V.; Jehle, J.-M.; Killias, M.; Shostko, O.; Smit, P.; Þórisdóttir, R.

    2010-01-01

    This is the fourth edition of a data collection initiative that started in 1993 under the umbrella of the Council of Europe. The present document covers the years of 2003-2006 for all areas. In-depth analysis are presented for the year 2006. The basic structure of five chapters - offences and offen

  19. NIOSH Manual of Analytical Methods (third edition). Fourth supplement

    Energy Technology Data Exchange (ETDEWEB)

    1990-08-15

    The NIOSH Manual of Analytical Methods, 3rd edition, was updated for the following chemicals: allyl-glycidyl-ether, 2-aminopyridine, aspartame, bromine, chlorine, n-butylamine, n-butyl-glycidyl-ether, carbon-dioxide, carbon-monoxide, chlorinated-camphene, chloroacetaldehyde, p-chlorophenol, crotonaldehyde, 1,1-dimethylhydrazine, dinitro-o-cresol, ethyl-acetate, ethyl-formate, ethylenimine, sodium-fluoride, hydrogen-fluoride, cryolite, sodium-hexafluoroaluminate, formic-acid, hexachlorobutadiene, hydrogen-cyanide, hydrogen-sulfide, isopropyl-acetate, isopropyl-ether, isopropyl-glycidyl-ether, lead, lead-oxide, maleic-anhydride, methyl-acetate, methyl-acrylate, methyl-tert-butyl ether, methyl-cellosolve-acetate, methylcyclohexanol, 4,4'-methylenedianiline, monomethylaniline, monomethylhydrazine, nitric-oxide, p-nitroaniline, phenyl-ether, phenyl-ether-biphenyl mixture, phenyl-glycidyl-ether, phenylhydrazine, phosphine, ronnel, sulfuryl-fluoride, talc, tributyl-phosphate, 1,1,2-trichloro-1,2,2-trifluoroethane, trimellitic-anhydride, triorthocresyl-phosphate, triphenyl-phosphate, and vinyl-acetate.

  20. Validation of the fifth edition BI-RADS ultrasound lexicon with comparison of fourth and fifth edition diagnostic performance using video clips

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Jung Hyun; Kim, Min Jung; Lee, Hye Sun [Yonsei University College of Medicine, Seoul (Korea, Republic of); Kim, Sung Hun [Dept. of Radiology, Seoul St. Mary' s Hospital, The Catholic University of Korea, Seoul(Korea, Republic of); Youk, Ji Hyun [Dept. of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of); Jeong, Sun Hye [Dept. of Radiology, Soonchunhyang University Bucheon Hospital, Bucheon (Korea, Republic of); Kim, You Me [Dept. of Radiology, Dankook University Hospital, Dankook University College of Medicine, Cheonan (Korea, Republic of)

    2016-08-15

    The aim of this study was to evaluate the positive predictive value (PPV) and the diagnostic performance of the ultrasonographic descriptors in the fifth edition of BI-RADS, comparing with the fourth edition using video clips. From September 2013 to July 2014, 80 breast masses in 74 women (mean age, 47.5±10.7 years) from five institutions of the Korean Society of Breast Imaging were included. Two radiologists individually reviewed the static and video images and analyzed the images according to the fourth and fifth edition of BI-RADS. The PPV of each descriptor was calculated and diagnostic performances between the fourth and fifth editions were compared. Of the 80 breast masses, 51 (63.8%) were benign and 29 (36.2%) were malignant. Suspicious ultrasonographic features such as irregular shape, non-parallel orientation, angular or spiculated margins, and combined posterior features showed higher PPV in both editions (all P<0.05). No significant differences were found in the diagnostic performances between the two editions (all P>0.05). The area under the receiver operating characteristics curve was higher in the fourth edition (0.708 to 0.690), without significance (P=0.416). The fifth edition of the BI-RADS ultrasound lexicon showed comparable performance to the fourth edition and can be useful in the differential diagnosis of breast masses using ultrasonography.

  1. Bifactor structure of the Wechsler Preschool and Primary Scale of Intelligence--Fourth Edition.

    Science.gov (United States)

    Watkins, Marley W; Beaujean, A Alexander

    2014-03-01

    The Wechsler Preschool and Primary Scale of Intelligence--Fourth Edition (WPPSI-IV; Wechsler, 2012) represents a substantial departure from its predecessor, including omission of 4 subtests, addition of 5 new subtests, and modification of the contents of the 5 retained subtests. Wechsler (2012) explicitly assumed a higher-order structure with general intelligence (g) as the second-order factor that explained all the covariation of several first-order factors but failed to consider a bifactor model. The WPPSI-IV normative sample contains 1,700 children aged 2 years and 6 months through 7 years and 7 months, bifurcated into 2 age groups: 2:6-3:11 year olds (n = 600) and 4:0-7:7 year olds (n = 1,100). This study applied confirmatory factor analysis to the WPPSI-IV normative sample data to test the fit of a bifactor model and to determine the reliability of the resulting factors. The bifactor model fit the WPPSI-IV normative sample data as well as or better than the higher-order models favored by Wechsler (2012). In the bifactor model, the general factor accounted for more variance in every subtest than did its corresponding domain-specific factor and the general factor accounted for more total and common variance than all domain-specific factors combined. Further, the domain-specific factors exhibited poor reliability independent of g (i.e., ωh coefficients of .05 to .33). These results suggest that only the general intelligence dimension was sufficiently robust and precise for clinical use.

  2. Investigating RNA editing factors from trypanosome mitochondria

    Science.gov (United States)

    Aphasizheva, Inna; Zhang, Liye; Aphasizhev, Ruslan

    2016-01-01

    Mitochondrial U-insertion/deletion mRNA editing is carried out by two principal multiprotein assemblies, enzymatic RNA editing core (RECC) and RNA editing substrate binding (RESC) complexes, and a plethora of auxiliary factors. An integral part of mitochondrial gene expression, editing receives inputs from primary mRNA and gRNA precursor processing pathways, and generates substrates for mRNA polyadenylation and translation. Although nearly all RECC-embedded enzymes have been implicated in specific editing reactions, the majority of proteins that populate the RESC are also essential for generating edited mRNAs. However, lack of recognizable motifs in RESC subunits limits the prowess of bioinformatics in guiding biochemical experiments and elucidating their specific biological functions. In this chapter, we describe a generic workflow for investigating mitochondrial mRNA editing in Trypanosoma brucei and focus on several methods that proved instrumental is assigning definitive functions to editing factors lacking known signature sequences. PMID:27020893

  3. Validation of the fifth edition BI-RADS ultrasound lexicon with comparison of fourth and fifth edition diagnostic performance using video clips

    Directory of Open Access Journals (Sweden)

    Jung Hyun Yoon

    2016-10-01

    Full Text Available Purpose The aim of this study was to evaluate the positive predictive value (PPV and the diagnostic performance of the ultrasonographic descriptors in the fifth edition of BI-RADS, comparing with the fourth edition using video clips. Methods From September 2013 to July 2014, 80 breast masses in 74 women (mean age, 47.5±10.7 years from five institutions of the Korean Society of Breast Imaging were included. Two radiologists individually reviewed the static and video images and analyzed the images according to the fourth and fifth edition of BI-RADS. The PPV of each descriptor was calculated and diagnostic performances between the fourth and fifth editions were compared. Results Of the 80 breast masses, 51 (63.8% were benign and 29 (36.2% were malignant. Suspicious ultrasonographic features such as irregular shape, non-parallel orientation, angular or spiculated margins, and combined posterior features showed higher PPV in both editions (all P0.05. The area under the receiver operating characteristics curve was higher in the fourth edition (0.708 to 0.690, without significance (P=0.416. Conclusion The fifth edition of the BI-RADS ultrasound lexicon showed comparable performance to the fourth edition and can be useful in the differential diagnosis of breast masses using ultrasonography.

  4. Material-specific retroactive interference effects of the Wechsler Adult Intelligence Scale-Fourth Edition on the Wechsler Memory Scale-Fourth Edition in a nonclinical sample.

    Science.gov (United States)

    Ingram, Nicolette S; Diakoumakos, Jessica V; Sinclair, Erin R; Crowe, Simon F

    2016-01-01

    This study investigated proactive and retroactive interference effects between the Wechsler Memory Scale-Fourth Edition (WMS-IV) using the flexible approach, and the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV). One hundred and eighty nonclinical participants were assigned to a four (visual interference, verbal interference, visual and verbal interference, vs. no interference) by two (retroactive vs. proactive) between-subjects design. The administration order of the tests was counterbalanced (i.e., administration of the WAIS-IV prior to the WMS-IV, and the WAIS-IV administered during the delay interval of the WMS-IV). The WAIS-IV produced significant retroactive interference effects on the WMS-IV; however, no proactive interference effect was observed. The retroactive interference effect was dependent on material specificity. The results indicate that material presented within the delay of the WMS-IV can have a significant effect on subsequent delayed recall. Clinicians should carefully consider the effects associated with carry-over effects of these tests when using them in combination.

  5. Comparison of Wechsler Memory Scale-Fourth Edition (WMS-IV) and Third Edition (WMS-III) dimensional structures: improved ability to evaluate auditory and visual constructs.

    Science.gov (United States)

    Hoelzle, James B; Nelson, Nathaniel W; Smith, Clifford A

    2011-03-01

    Dimensional structures underlying the Wechsler Memory Scale-Fourth Edition (WMS-IV) and Wechsler Memory Scale-Third Edition (WMS-III) were compared to determine whether the revised measure has a more coherent and clinically relevant factor structure. Principal component analyses were conducted in normative samples reported in the respective technical manuals. Empirically supported procedures guided retention of dimensions. An invariant two-dimensional WMS-IV structure reflecting constructs of auditory learning/memory and visual attention/memory (C1 = .97; C2 = .96) is more theoretically coherent than the replicable, heterogeneous WMS-III dimension (C1 = .97). This research suggests that the WMS-IV may have greater utility in identifying lateralized memory dysfunction.

  6. Structural and incremental validity of the Wechsler Adult Intelligence Scale-Fourth Edition with a clinical sample.

    Science.gov (United States)

    Nelson, Jason M; Canivez, Gary L; Watkins, Marley W

    2013-06-01

    Structural and incremental validity of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV; Wechsler, 2008a) was examined with a sample of 300 individuals referred for evaluation at a university-based clinic. Confirmatory factor analysis indicated that the WAIS-IV structure was best represented by 4 first-order factors as well as a general intelligence factor in a direct hierarchical model. The general intelligence factor accounted for the most common and total variance among the subtests. Incremental validity analyses indicated that the Full Scale IQ (FSIQ) generally accounted for medium to large portions of academic achievement variance. For all measures of academic achievement, the first-order factors combined accounted for significant achievement variance beyond that accounted for by the FSIQ, but individual factor index scores contributed trivial amounts of achievement variance. Implications for interpreting WAIS-IV results are discussed. (PsycINFO Database Record (c) 2013 APA, all rights reserved).

  7. Validating the Learning Disability Screening Questionnaire Against the Weschler Adult Intelligence Scale, Fourth Edition.

    Science.gov (United States)

    McKenzie, Karen; Sharples, Phil; Murray, Aja L

    2015-08-01

    The Learning Disability Screening Questionnaire (LDSQ), a brief screening tool for intellectual disability, was originally validated against the Weschler Adult Intelligence Scale, Third Edition (WAIS-III), which was superseded by the Weschler Adult Intelligence Scale, Fourth Edition (WAIS-IV) in the United Kingdom in 2010. This study examines the performance of the LDSQ using the WAIS-IV as the diagnostic intellectual assessment. Based on the original optimal cut-off score, the LDSQ sensitivity value was equivalent (91%) to that obtained in the original validation study, and the specificity value was higher at 92%. This suggests that the LDSQ remains valid when using the WAIS-IV as the comparative intellectual assessment.

  8. Performance on selected visual and auditory subtests of the Wechsler Memory Scale-Fourth Edition during laboratory-induced pain.

    Science.gov (United States)

    Etherton, Joseph L; Tapscott, Brian E

    2015-01-01

    Although chronic pain patients commonly report problems with concentration and memory, recent research indicates that induced pain alone causes little or no impairment on several Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) subtests, suggesting that cognitive complaints in chronic pain may be attributable to factors other than pain. The current studies examined potential effects of induced pain on Wechsler Memory Scale-Fourth Edition (WMS-IV) visual working memory index (VWM) subtests (Experiment 1, n = 32) and on the immediate portions of WMS-IV auditory memory (IAM) subtests (Experiment 2, n = 55). In both studies, participants were administered one of two subtests (Symbol Span or Spatial Addition for Experiment 1; Logical Memory or Verbal Paired Associates for Experiment 2) normally and were then administered the alternate subtest while experiencing either cold pressor pain induction or a nonpainful control condition. Results indicate that induced pain in nonclinical volunteers did not impair performance on either VWM or IAM performance, suggesting that pain alone does not account for complaints or deficits in these domains in chronic pain patients. Nonpainful variables such as sleep deprivation or emotional disturbance may be responsible for reported cognitive complaints in chronic pain patients.

  9. THE FOURTH EDITION OF THE EUROPEAN VOLLEYBALL CHAMPIONSHIP, BUCHAREST 1955 – AN ANALYTICAL APPROACH

    Directory of Open Access Journals (Sweden)

    Ileana-Monica Popovici

    2016-10-01

    Full Text Available From 15 to 26 June 1955, the Romanian capital hosted the fourth edition of the European Volleyball Championship, both women and men. This edition, scheduled four years after the previous one, also registered a record of participation for those times: 14 teams entered the men’s competition and 6 attended the women’s. In the end, the Romanian men representative occupied an honourable second position in the charts, while the women were only fourth. The European titles went to Czechoslovakia, which clearly dominated the competition. The tournament was programmed to take place in Floreasca Hall and Dinamo Sports Park in Bucharest. The main aim of our present study is that of providing a detailed analysis of this sports event, which belongs to a period when the European volleyball championships did not have a regular scheduling, and the number of competing teams was not officially pre-established. Our second goal is that of framing this competition into the larger political context which deeply influenced its development. The sports event happening in Bucharest proved to be a success, both from the perspective of the quality of the featured competitions, and from the organizational point of view, thus placing the country among the select few volleyball promoters worldwide

  10. Test Review: Abidin, R. R. (2012) "Parenting Stress Index, Fourth Edition" ("PSI-4"). Lutz, Florida: Psychological Assessment Resources

    Science.gov (United States)

    Johnson, Alyce O.

    2015-01-01

    The "Parenting Stress Index, Fourth Edition" (PSI-4) is a 120-item measure used to explore parental stress levels considering a parent's relationship with one of his or her children between the ages of 1 month and 12 years. The main purpose of the test is to define these stress levels and from where they originate in order to identify…

  11. Test Review: Wechsler, D. (2005). "Wechsler Intelligence Scale for Children-Fourth Edition Spanish." San Antonio, TX: Harcourt Assessment

    Science.gov (United States)

    Braden, Jeffery P.; Iribarren, Jacqueline A.

    2007-01-01

    In this article, the authors review the Wechsler Intelligence Scale for Children-Fourth Edition Spanish (WISC-IV Spanish), a Spanish translation and adaptation of the WISC-IV. The test was developed to measure the intellectual ability of Spanish-speaking children in the United States ages 6 years, 0 months, through 16 years, 11 months. These…

  12. Temporal stability of the Dutch version of the Wechsler Memory Scale - Fourth Edition (WMS-IV-NL)

    NARCIS (Netherlands)

    Bouman, Z.; Hendriks, M.P.H.; Aldenkamp, A.P.; Kessels, R.P.C.

    2015-01-01

    Objective: The Wechsler Memory Scale - Fourth Edition (WMS-IV) is one of the most widely used memory batteries. We examined the test–retest reliability, practice effects, and standardized regression-based (SRB) change norms for the Dutch version of the WMS-IV (WMS-IV-NL) after both short and long re

  13. Clinical utility of the Wechsler Memory Scale - Fourth Edition (WMS-IV) in patients with intractable temporal lobe epilepsy

    NARCIS (Netherlands)

    Bouman, Z.; Elhorst, D.; Hendriks, M.P.H.; Kessels, R.P.C.; Aldenkamp, A.P.

    2016-01-01

    Introduction: The Wechsler Memory Scale (WMS) is one of the most widely used test batteries to assess memory functions in patients with brain dysfunctions of different etiologies. This study examined the clinical validation of the Dutch Wechsler Memory Scale-Fourth Edition (WMS-IV-NL) in patients wi

  14. European guidelines for quality assurance in breast cancer screening and diagnosis. Fourth edition--summary document.

    Science.gov (United States)

    Perry, N; Broeders, M; de Wolf, C; Törnberg, S; Holland, R; von Karsa, L

    2008-04-01

    Breast cancer is a major cause of suffering and death and is of significant concern to many women. Early detection of breast cancer by systematic mammography screening can find lesions for which treatment is more effective and generally more favourable for quality of life. The potential harm caused by mammography includes the creation of unnecessary anxiety and morbidity, inappropriate economic cost and the use of ionising radiation. It is for this reason that the strongest possible emphasis on quality control and quality assurance is required. Development of the European Guidelines for Quality Assurance in Breast Cancer Screening and Diagnosis has been an initiative within the Europe Against Cancer Programme. The fourth edition of the multidisciplinary guidelines was published in 2006 and comprises approximately 400 pages divided into 12 chapters prepared by >200 authors and contributors. The multidisciplinary editorial board has prepared a summary document to provide an overview of the fundamental points and principles that should support any quality screening or diagnostic service. This document includes a summary table of key performance indicators and is presented here in order to make these principles and standards known to a wider scientific community.

  15. Wechsler Adult Intelligence Scale-Fourth Edition performance in relapsing-remitting multiple sclerosis.

    Science.gov (United States)

    Ryan, Joseph J; Gontkovsky, Samuel T; Kreiner, David S; Tree, Heather A

    2012-01-01

    Forty patients with relapsing-remitting multiple sclerosis (MS) completed the 10 core Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) subtests. Means for age and education were 42.05 years (SD = 9.94) and 14.33 years (SD = 2.40). For all participants, the native language was English. The mean duration of MS diagnosis was 8.17 years (SD = 7.75), and the mean Expanded Disability Status Scale (EDSS; Kurtzke, 1983 ) score was 3.73 (SD = 1.41) with a range from 2.0 to 6.5. A control group of healthy individuals with similar demographic characteristics also completed the WAIS-IV and were provided by the test publisher. Compared to controls, patients with MS earned significantly lower subtest and composite scores. The patients' mean scores were consistently in the low-average to average range, and the patterns of performance across groups did not differ significantly, although there was a trend towards higher scores on the Verbal Comprehension Index (VCI) and lower scores on the Processing Speed Index (PSI). Approximately 78% of patients had actual Full Scale IQs that were significantly lower than preillness, demographically based IQ estimates.

  16. Comparing Canadian and American normative scores on the Wechsler Adult Intelligence Scale-Fourth Edition.

    Science.gov (United States)

    Harrison, Allyson G; Armstrong, Irene T; Harrison, Laura E; Lange, Rael T; Iverson, Grant L

    2014-12-01

    Psychologists practicing in Canada must decide which set of normative data to use for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV). The purpose of this study was to compare the interpretive effects of applying American versus Canadian normative systems in a sample of 432 Canadian postsecondary-level students who were administered the WAIS-IV as part of an evaluation for a learning disability, attention-deficit hyperactivity disorder, or other mental health problems. Employing the Canadian normative system yielded IQ, Index, and subtest scores that were systematically lower than those obtained using the American norms. Furthermore, the percentage agreement in normative classifications, defined as American and Canadian index scores within five points or within the same classification range, was between 49% and 76%. Substantial differences are present between the American and Canadian WAIS-IV norms. Clinicians should consider carefully the implications regarding which normative system is most appropriate for specific types of evaluations. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Book Review: Potassic igneous rocks and associated gold-copper mineralization, Fourth edition (D. Muller and D.I. Groves)

    Science.gov (United States)

    Kelley, Karen D.

    2016-01-01

    The fourth edition of this comprehensive textbook, which succeeds those published in 1995, 1997, and 2000, very nicely summarizes the geochemical and petrological characteristics of potassic igneous rock complexes and the different tectonic settings in which they occur. The authors provide an overview and a classification of these rocks and they outline the geochemical differences between barren and mineralized potassic igneous complexes. Owing to the common association of potassic igneous rocks with many gold- and copper-rich ore deposits, this book will be of interest not only to research scientists but also to those exploring for major deposits in young and ancient terranes. In fact, there was a clear attempt by the authors to provide a good mix of theoretical discussions based on experimental work, with case studies that illustrate field and applied research.

  18. Construct Validity of the Wechsler Intelligence Scale for Children-Fourth UK Edition with a Referred Irish Sample: Wechsler and Cattell-Horn-Carroll Model Comparisons with 15 Subtests

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.; Good, Rebecca; James, Kate; James, Trevor

    2017-01-01

    Background: Irish educational psychologists frequently use the Wechsler Intelligence Scale for Children-Fourth UK Edition (WISC-IV[superscript UK]; Wechsler, 2004, Wechsler Intelligence Scale for Children-Fourth UK Edition, London, UK, Harcourt Assessment) in clinical assessments of children with learning difficulties. Unfortunately, reliability…

  19. Test Review: C. Mardell & D. S. Goldenberg. "Speed Developmental Indicators for the Assessment of Learning-Fourth Edition" ("Speed DIAL-4")

    Science.gov (United States)

    Doskey, Elena M.; Lagunas, Brenda; SooHoo, Michelle; Lomax, Amanda; Bullick, Stephanie

    2013-01-01

    The Speed DIAL-4 was developed from the Developmental Indicators for the Assessment of Learning, Fourth Edition (DIAL-4), a screening designed to identify children between the ages of 2 years, 6 months through 5 years, 11 months "who are in need of intervention or diagnostic assessment in the following areas: motor, concepts, language,…

  20. Clinical validation of three short forms of the Dutch Wechsler Memory Scale – Fourth Edition (WMS-IV-NL) in a mixed clinical sample

    NARCIS (Netherlands)

    Bouman, Z.; Hendriks, M.P.H.; Veld, W.M. van der; Aldenkamp, A.P.; Kessels, R.P.C.

    2016-01-01

    The reliability and validity of three short forms of the Dutch version of the Wechsler Memory Scale–Fourth Edition (WMS-IV-NL) were evaluated in a mixed clinical sample of 235 patients. The short forms were based on the WMS-IV Flexible Approach, that is, a 3-subtest combination (Older Adult Battery

  1. Independent Examination of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): What Does the WAIS-IV Measure?

    Science.gov (United States)

    Benson, Nicholas; Hulac, David M.; Kranzler, John H.

    2010-01-01

    Published empirical evidence for the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV) does not address some essential questions pertaining to the applied practice of intellectual assessment. In this study, the structure and cross-age invariance of the latest WAIS-IV revision were examined to (a) elucidate the nature of the constructs…

  2. Implications for Educational Classification and Psychological Diagnoses Using the Wechsler Adult Intelligence Scale-Fourth Edition with Canadian versus American Norms

    Science.gov (United States)

    Harrison, Allyson G.; Holmes, Alana; Silvestri, Robert; Armstrong, Irene T.

    2015-01-01

    Building on a recent work of Harrison, Armstrong, Harrison, Iverson and Lange which suggested that Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) scores might systematically overestimate the severity of intellectual impairments if Canadian norms are used, the present study examined differences between Canadian and American derived…

  3. Independent Examination of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV): What Does the WAIS-IV Measure?

    Science.gov (United States)

    Benson, Nicholas; Hulac, David M.; Kranzler, John H.

    2010-01-01

    Published empirical evidence for the Wechsler Adult Intelligence Scale--Fourth Edition (WAIS-IV) does not address some essential questions pertaining to the applied practice of intellectual assessment. In this study, the structure and cross-age invariance of the latest WAIS-IV revision were examined to (a) elucidate the nature of the constructs…

  4. Implications for Educational Classification and Psychological Diagnoses Using the Wechsler Adult Intelligence Scale-Fourth Edition with Canadian versus American Norms

    Science.gov (United States)

    Harrison, Allyson G.; Holmes, Alana; Silvestri, Robert; Armstrong, Irene T.

    2015-01-01

    Building on a recent work of Harrison, Armstrong, Harrison, Iverson and Lange which suggested that Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) scores might systematically overestimate the severity of intellectual impairments if Canadian norms are used, the present study examined differences between Canadian and American derived…

  5. Seeing the Forest for the Trees: Prevalence of Low Scores on the Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV)

    Science.gov (United States)

    Brooks, Brian L.

    2010-01-01

    Low scores across a battery of tests are common in healthy people and vary by demographic characteristics. The purpose of the present article was to present the base rates of low scores for the Wechsler Intelligence Scale for Children, fourth edition (WISC-IV; D. Wechsler, 2003). Participants included 2,200 children and adolescents between 6 and…

  6. The Effects of Wechsler Intelligence Scale for Children-Fourth Edition Cognitive Abilities on Math Achievement

    Science.gov (United States)

    Parkin, Jason R.; Beaujean, A. Alexander

    2012-01-01

    This study used structural equation modeling to examine the effect of Stratum III (i.e., general intelligence) and Stratum II (i.e., Comprehension-Knowledge, Fluid Reasoning, Short-Term Memory, Processing Speed, and Visual Processing) factors of the Cattell-Horn-Carroll (CHC) cognitive abilities, as operationalized by the Wechsler Intelligence…

  7. Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans.

    Science.gov (United States)

    Washburn, Michael C; Hundley, Heather A

    2016-05-01

    Adenosine-to-inosine RNA editing by ADARs affects thousands of adenosines in an organism's transcriptome. However, adenosines are not edited at equal levels nor do these editing levels correlate well with ADAR expression levels. Therefore, additional mechanisms are utilized by the cell to dictate the editing efficiency at a given adenosine. To examine cis-and trans-acting factors that regulate A-to-I editing levels specifically in neural cells, we utilized the model organism Caenorhabditis elegans We demonstrate that a double-stranded RNA (dsRNA) binding protein, ADR-1, inhibits editing in neurons, which is largely masked when examining editing levels from whole animals. Furthermore, expression of ADR-1 and mRNA expression of the editing target can act synergistically to regulate editing efficiency. In addition, we identify a dsRNA region within the Y75B8A.83' UTR that acts as acis-regulatory element by enhancing ADR-2 editing efficiency. Together, this work identifies mechanisms that regulate editing efficiency of noncoding A-to-I editing sites, which comprise the largest class of ADAR targets.

  8. School Law. Fourth Edition.

    Science.gov (United States)

    Ware, Martha L.; Remmlein, Madaline Kinter

    This volume presents the legal principles and judicial interpretations that constitute the legal framework within which teachers work. Part 1, on problems of teacher personnel, covers such legal issues as certification and employment, contracts, dismissals, and loyalty requirements. Part 2 concerns legal issues related to race and the schools.…

  9. Classical Mythology. Fourth Edition.

    Science.gov (United States)

    Morford, Mark P. O.; Lenardon, Robert J.

    Designed for students with little or no background in classical literature, this book introduces the Greek and Roman myths of creation, myths of the gods, Greek sagas and local legends, and presents contemporary theories about the myths. Drawing on Homer, Hesiod, Pindar, Vergil, and others, the book provides many translations and paraphrases of…

  10. Hans Rose, Commentary to Heinrich Wölfflin, Renaissance and Baroque, fourth edition, Munich: Bruckmann, 1926, 181-328, translation by Arnold Witte and Andrew Hopkins

    Directory of Open Access Journals (Sweden)

    Arnold Witte

    2016-06-01

    Full Text Available The Commentary by Hans Rose was published as an appendix to the fourth edition of Heinrich Wölfflin’s Renaissance und Barock - eine Untersuchung über Wesen und Entstehung des Barockstils in Italien, published in 1926. It was almost as long as the original text by Wölfflin and intended to discuss the new approaches on the Italian Baroque developed in German academia in the 1920s. It was divided up into four sections of unequal length, which discuss Subjectivism, Material and Colour, Urban Planning, and St Peter’s respectively.

  11. Epilepsy & IQ: the clinical utility of the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) indices in the neuropsychological assessment of people with epilepsy.

    Science.gov (United States)

    Baxendale, Sallie; McGrath, Katherine; Thompson, Pamela J

    2014-01-01

    We examined Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) General Ability Index (GAI) and Full Scale Intelligence Quotient (FSIQ) discrepancies in 100 epilepsy patients; 44% had a significant GAI > FSIQ discrepancy. GAI-FSIQ discrepancies were correlated with the number of antiepileptic drugs taken and duration of epilepsy. Individual antiepileptic drugs differentially interfere with the expression of underlying intellectual ability in this group. FSIQ may significantly underestimate levels of general intellectual ability in people with epilepsy. Inaccurate representations of FSIQ due to selective impairments in working memory and reduced processing speed obscure the contextual interpretation of performance on other neuropsychological tests, and subtle localizing and lateralizing signs may be missed as a result.

  12. Strategic Competence as a Fourth-Order Factor Model: A Structural Equation Modeling Approach

    Science.gov (United States)

    Phakiti, Aek

    2008-01-01

    This article reports on an empirical study that tests a fourth-order factor model of strategic competence through the use of structural equation modeling (SEM). The study examines the hierarchical relationship of strategic competence to (a) strategic knowledge of cognitive and metacognitive strategy use in general (i.e., trait) and (b) strategic…

  13. Concurrent Validity of the Cognitive Domain of the Battelle Developmental Inventory in Relation to the Stanford-Binet Intelligence Test, Fourth Edition for Urban African-American Low SES Preschool Children.

    Science.gov (United States)

    Lidz, Carol S.; And Others

    The relationship between scores on the cognitive domain of the Battelle Developmental Inventory (BDI) and scores on the Stanford-Binet Intelligence Test (SBIT), Fourth Edition, was studied for 32 urban, low socioeconomic status (SES), African American children (22 males and 10 females) aged 3 to 5 years. The BDI is a developmental inventory…

  14. Structure of the Wechsler Intelligence Scale for Children - Fourth Edition in a Group of Children with ADHD.

    Science.gov (United States)

    Gomez, Rapson; Vance, Alasdair; Watson, Shaun D

    2016-01-01

    This study used confirmatory factor analysis to examine the factor structure for the 10 core WISC-IV subtests in a group of children (N = 812) with ADHD. The study examined oblique four- and five-factor models, higher order models with one general secondary factor and four and five primary factors, and a bifactor model with a general factor and four specific factors. The findings supported all models tested, with the bifactor model being the optimum model. For this model, only the general factor had high explained common variance and omega hierarchical value, and it predicted reading and arithmetic abilities. The findings favor the use of the FSIQ scores of the WISC-IV, but not the subscale index scores.

  15. Structure of the Wechsler Intelligence Scale for Children – Fourth Edition in a Group of Children with ADHD

    Science.gov (United States)

    Gomez, Rapson; Vance, Alasdair; Watson, Shaun D.

    2016-01-01

    Objective: This study used confirmatory factor analysis to examine the factor structure for the 10 core WISC–IV subtests in a group of children (N = 812) with ADHD. Method: The study examined oblique four- and five-factor models, higher order models with one general secondary factor and four and five primary factors, and a bifactor model with a general factor and four specific factors. Results: The findings supported all models tested, with the bifactor model being the optimum model. For this model, only the general factor had high explained common variance and omega hierarchical value, and it predicted reading and arithmetic abilities. Conclusion: The findings favor the use of the FSIQ scores of the WISC-IV, but not the subscale index scores. PMID:27303319

  16. Concurrent validity of persian version of wechsler intelligence scale for children - fourth edition and cognitive assessment system in patients with learning disorder.

    Science.gov (United States)

    Rostami, Reza; Sadeghi, Vahid; Zarei, Jamileh; Haddadi, Parvaneh; Mohazzab-Torabi, Saman; Salamati, Payman

    2013-04-01

    The aim of this study was to compare the Persian version of the wechsler intelligence scale for children - fourth edition (WISC-IV) and cognitive assessment system (CAS) tests, to determine the correlation between their scales and to evaluate the probable concurrent validity of these tests in patients with learning disorders. One-hundered-sixty-two children with learning disorder who were presented at Atieh Comprehensive Psychiatry Center were selected in a consecutive non-randomized order. All of the patients were assessed based on WISC-IV and CAS scores questionnaires. Pearson correlation coefficient was used to analyze the correlation between the data and to assess the concurrent validity of the two tests. Linear regression was used for statistical modeling. The type one error was considered 5% in maximum. There was a strong correlation between total score of WISC-IV test and total score of CAS test in the patients (r=0.75, PWISC-IV scales and CAS test in children with learning disorders. A concurrent validity is established between the two tests and their scales.

  17. Clinical utility of the Wechsler Memory Scale--Fourth Edition (WMS-IV) in predicting laterality of temporal lobe epilepsy among surgical candidates.

    Science.gov (United States)

    Soble, Jason R; Eichstaedt, Katie E; Waseem, Hena; Mattingly, Michelle L; Benbadis, Selim R; Bozorg, Ali M; Vale, Fernando L; Schoenberg, Mike R

    2014-12-01

    This study evaluated the accuracy of the Wechsler Memory Scale--Fourth Edition (WMS-IV) in identifying functional cognitive deficits associated with seizure laterality in localization-related temporal lobe epilepsy (TLE) relative to a previously established measure, the Rey Auditory Verbal Learning Test (RAVLT). Emerging WMS-IV studies have highlighted psychometric improvements that may enhance its ability to identify lateralized memory deficits. Data from 57 patients with video-EEG-confirmed unilateral TLE who were administered the WMS-IV and RAVLT as part of a comprehensive presurgical neuropsychological evaluation for temporal resection were retrospectively reviewed. We examined the predictive accuracy of the WMS-IV not only in terms of verbal versus visual composite scores but also using individual subtests. A series of hierarchal logistic regression models were developed, including the RAVLT, WMS-IV delayed subtests (Logical Memory, Verbal Paired Associates, Designs, Visual Reproduction), and a WMS-IV verbal-visual memory difference score. Analyses showed that the RAVLT significantly predicted laterality with overall classification rates of 69.6% to 70.2%, whereas neither the individual WMS-IV subtests nor the verbal-visual memory difference score accounted for additional significant variance. Similar to previous versions of the WMS, findings cast doubt as to whether the WMS-IV offers significant incremental validity in discriminating seizure laterality in TLE beyond what can be obtained from the RAVLT.

  18. Memory functioning in individuals with traumatic brain injury: an examination of the Wechsler Memory Scale-Fourth Edition (WMS-IV).

    Science.gov (United States)

    Carlozzi, Noelle E; Grech, Julie; Tulsky, David S

    2013-01-01

    This study was designed to examine the construct validity of the Wechsler Memory Scale-Fourth Edition (WMS-IV) in individuals with traumatic brain injury (TBI). One hundred individuals with TBI (n = 35 complicated mild/moderate TBI; n = 65 severe TBI) and 100 matched controls from the WMS-IV normative dataset completed the WMS-IV. Multivariate analyses indicated that severe TBI participants had poorer performance than matched controls on all index scores and subtests. Individuals with complicated mild/moderate TBI performed more poorly than controls on all index scores, as well as on tests of visual memory (Designs I and II; Visual Reproduction I and II) and visual working memory (Spatial Addition; Symbol Span), but not on auditory verbal memory tests (Logical Memory I and II; Verbal Paired Associates I and II). After controlling for time since injury, severe TBI participants had significantly lower scores than the complicated mild/moderate TBI on 4 of the 5 WMS-IV index scores (Auditory Memory, Visual Memory, Immediate Memory, Delayed Memory) and 4 of the 10 WMS-IV subtests (Designs I and II, Verbal Pairs II, Logical Memory II). Effect sizes for index and subtest scores were generally moderate for the complicated mild/moderate group and moderate-to-large for the severe TBI group. Findings provide support for the construct validity of the WMS-IV in individuals with TBI.

  19. Clinical validation of three short forms of the Dutch Wechsler Memory Scale-Fourth Edition (WMS-IV-NL) in a mixed clinical sample.

    Science.gov (United States)

    Bouman, Zita; Hendriks, Marc P H; Van Der Veld, William M; Aldenkamp, Albert P; Kessels, Roy P C

    2016-06-01

    The reliability and validity of three short forms of the Dutch version of the Wechsler Memory Scale-Fourth Edition (WMS-IV-NL) were evaluated in a mixed clinical sample of 235 patients. The short forms were based on the WMS-IV Flexible Approach, that is, a 3-subtest combination (Older Adult Battery for Adults) and two 2-subtest combinations (Logical Memory and Visual Reproduction and Logical Memory and Designs), which can be used to estimate the Immediate, Delayed, Auditory and Visual Memory Indices. All short forms showed good reliability coefficients. As expected, for adults (16-69 years old) the 3-subtest short form was consistently more accurate (predictive accuracy ranged from 73% to 100%) than both 2-subtest short forms (range = 61%-80%). Furthermore, for older adults (65-90 years old), the predictive accuracy of the 2-subtest short form ranged from 75% to 100%. These results suggest that caution is warranted when using the WMS-IV-NL Flexible Approach short forms to estimate all four indices.

  20. An examination of the Wechsler Adult Intelligence Scales, Fourth Edition (WAIS-IV) in individuals with complicated mild, moderate and Severe traumatic brain injury (TBI).

    Science.gov (United States)

    Carlozzi, Noelle E; Kirsch, Ned L; Kisala, Pamela A; Tulsky, David S

    2015-01-01

    This study examined the clinical utility of the Wechsler Adult Intelligence Scales-Fourth Edition (WAIS-IV) in individuals with complicated mild, moderate or severe TBI. One hundred individuals with TBI (n = 35 complicated mild or moderate TBI; n = 65 severe TBI) and 100 control participants matched on key demographic variables from the WAIS-IV normative dataset completed the WAIS-IV. Univariate analyses indicated that participants with severe TBI had poorer performance than matched controls on all index scores and subtests (except Matrix Reasoning). Individuals with complicated mild/moderate TBI performed more poorly than controls on the Working Memory Index (WMI), Processing Speed Index (PSI), and Full Scale IQ (FSIQ), and on four subtests: the two processing speed subtests (SS, CD), two working memory subtests (AR, LN), and a perceptual reasoning subtest (BD). Participants with severe TBI had significantly lower scores than the complicated mild/moderate TBI on PSI, and on three subtests: the two processing speed subtests (SS and CD), and the new visual puzzles test. Effect sizes for index and subtest scores were generally small-to-moderate for the group with complicated mild/moderate and moderate-to-large for the group with severe TBI. PSI also showed good sensitivity and specificity for classifying individuals with severe TBI versus controls. Findings provide support for the clinical utility of the WAIS-IV in individuals with complicated mild, moderate, and severe TBI.

  1. Optical determination of rock-forming minerals — Part I determinative tables W.E. Tröger, 1979. English edition of the fourth German edition by H.U. Bambauer, F. Taborszky and H.D. Trochim. Schweizerbartsche Verlagsbuchhandlung, Stuttgart, 188 pp., DM 48.00, U.S. $ 27.00

    NARCIS (Netherlands)

    Sauter, P.C.C.

    1980-01-01

    This book is the English translation of the fourth German edition of Tröger's Optische Bestimmung der gesteinsbildenden Minerale, Tell I: Bestimmungstabellen. Part II, the descriptive text volume, is only available in German. These Determinative Tables contain data on optical, crystallographic, phys

  2. Optical determination of rock-forming minerals — Part I determinative tables W.E. Tröger, 1979. English edition of the fourth German edition by H.U. Bambauer, F. Taborszky and H.D. Trochim. Schweizerbartsche Verlagsbuchhandlung, Stuttgart, 188 pp., DM 48.00, U.S. $ 27.00

    NARCIS (Netherlands)

    Sauter, P.C.C.

    1980-01-01

    This book is the English translation of the fourth German edition of Tröger's Optische Bestimmung der gesteinsbildenden Minerale, Tell I: Bestimmungstabellen. Part II, the descriptive text volume, is only available in German. These Determinative Tables contain data on optical,

  3. Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) processing speed scores as measures of noncredible responding: The third generation of embedded performance validity indicators.

    Science.gov (United States)

    Erdodi, Laszlo A; Abeare, Christopher A; Lichtenstein, Jonathan D; Tyson, Bradley T; Kucharski, Brittany; Zuccato, Brandon G; Roth, Robert M

    2017-02-01

    Research suggests that select processing speed measures can also serve as embedded validity indicators (EVIs). The present study examined the diagnostic utility of Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) subtests as EVIs in a mixed clinical sample of 205 patients medically referred for neuropsychological assessment (53.3% female, mean age = 45.1). Classification accuracy was calculated against 3 composite measures of performance validity as criterion variables. A PSI ≤79 produced a good combination of sensitivity (.23-.56) and specificity (.92-.98). A Coding scaled score ≤5 resulted in good specificity (.94-1.00), but low and variable sensitivity (.04-.28). A Symbol Search scaled score ≤6 achieved a good balance between sensitivity (.38-.64) and specificity (.88-.93). A Coding-Symbol Search scaled score difference ≥5 produced adequate specificity (.89-.91) but consistently low sensitivity (.08-.12). A 2-tailed cutoff on the Coding/Symbol Search raw score ratio (≤1.41 or ≥3.57) produced acceptable specificity (.87-.93), but low sensitivity (.15-.24). Failing ≥2 of these EVIs produced variable specificity (.81-.93) and sensitivity (.31-.59). Failing ≥3 of these EVIs stabilized specificity (.89-.94) at a small cost to sensitivity (.23-.53). Results suggest that processing speed based EVIs have the potential to provide a cost-effective and expedient method for evaluating the validity of cognitive data. Given their generally low and variable sensitivity, however, they should not be used in isolation to determine the credibility of a given response set. They also produced unacceptably high rates of false positive errors in patients with moderate-to-severe head injury. Combining evidence from multiple EVIs has the potential to improve overall classification accuracy. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  4. The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells

    Energy Technology Data Exchange (ETDEWEB)

    Galloway, Chad A. [Department of Biochemistry and Biophysics, University of Rochester School of Medicine, 601 Elmwood Ave., Rochester, NY 14642 (United States); Smith, Harold C., E-mail: harold.smith@rochester.edu [Department of Biochemistry and Biophysics, University of Rochester School of Medicine, 601 Elmwood Ave., Rochester, NY 14642 (United States)

    2010-01-01

    Apolipoprotein B mRNA is edited at cytidine 6666 in the enterocytes lining the small intestine of all mammals; converting a CAA codon to a UAA stop codon. The conversion is {approx}80% efficient in this tissue and leads to the expression of the truncated protein, ApoB48, essential for secretion of dietary lipid as chylomicrons. Caco-2 cell raft cultures have been used as an in vitro model for the induction of editing activity during human small intestinal cell differentiation. This induction of apoB mRNA editing has been ascribed to the expression of APOBEC-1. In agreement our data demonstrated differentiation-dependent induction of expression of the editing enzyme APOBEC-1 and in addition we show alternative splicing of the essential auxiliary factor ACF. However, transfection of these editing factors in undifferentiated proliferating Caco-2 cells was not sufficient to induce robust apoB mRNA editing activity. Only differentiation of Caco-2 cells could induce more physiological like levels of apoB mRNA editing. The data suggested that additional regulatory mechanism(s) were induced by differentiation that controlled the functional activity of editing factors.

  5. Communications Style Guide. Fourth Edition

    Science.gov (United States)

    2010-08-01

    red = economic). When you review the text before an important exam or before sitting down to draft a paper, your post-it notes should lead you to...practice your presentation.  Avoid excess caffeine or alcohol: Alcohol and caffeine can affect your nervous system and may make it difficult for you

  6. Introduction to Psychology. Fourth Edition.

    Science.gov (United States)

    Kalat, James W.

    Chapters in this textbook for college students in introductory psychology courses are: (1) What is Psychology?; (2) Scientific Methods in Psychology; (3) Biological Psychology; (4) Sensation and Perception; (5) Altered States; (6) Learning; (7) Memory; (8) Cognition and Language; (9) Intelligence and Its Measurement; (10) Development; (11)…

  7. Performance of Fourth-Grade Students in the 2012 NAEP Computer-Based Writing Pilot Assessment: Scores, Text Length, and Use of Editing Tools. Working Paper Series. NCES 2015-119

    Science.gov (United States)

    White, Sheida; Kim, Young Yee; Chen, Jing; Liu, Fei

    2015-01-01

    This study examined whether or not fourth-graders could fully demonstrate their writing skills on the computer and factors associated with their performance on the National Assessment of Educational Progress (NAEP) computer-based writing assessment. The results suggest that high-performing fourth-graders (those who scored in the upper 20 percent…

  8. Factors associated with fourth grade health education scores on the Maine Educational Assessment.

    Science.gov (United States)

    Stroble, L P

    1997-02-01

    Data collected in 1994 on the health section of the fourth grade Maine Educational Assessment (MEA) were analyzed in this study. Correlational studies and analyses of variance tested significance of community, school, and teacher variables. A multiple regression analysis with a path model determined significant factors associated with achievement in health. The most salient finding was that students' overall ability--represented by achievement in the other MEA content areas--related strongly to achievement in health. Community socioeconomic status emerged as another significant influence on health scores. Type of health education program did not make a difference in scores, but any method of delivering health education, in contrast to no health education affected health scores significantly. Up to 30 minutes of instruction per week yielded the highest mean scores. The teachers' rating of the health program emerged as a pivotal variable.

  9. Confirmatory Factor Analysis of the WAIS-IV/WMS-IV

    Science.gov (United States)

    Holdnack, James A.; Zhou, Xiaobin; Larrabee, Glenn J.; Millis, Scott R.; Salthouse, Timothy A.

    2011-01-01

    The Wechsler Adult Intelligence Scale-fourth edition (WAIS-IV) and the Wechsler Memory Scale-fourth edition (WMS-IV) were co-developed to be used individually or as a combined battery of tests. The independent factor structure of each of the tests has been identified; however, the combined factor structure has yet to be determined. Confirmatory…

  10. Confirmatory Factor Analysis of the WAIS-IV/WMS-IV

    Science.gov (United States)

    Holdnack, James A.; Zhou, Xiaobin; Larrabee, Glenn J.; Millis, Scott R.; Salthouse, Timothy A.

    2011-01-01

    The Wechsler Adult Intelligence Scale-fourth edition (WAIS-IV) and the Wechsler Memory Scale-fourth edition (WMS-IV) were co-developed to be used individually or as a combined battery of tests. The independent factor structure of each of the tests has been identified; however, the combined factor structure has yet to be determined. Confirmatory…

  11. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    Science.gov (United States)

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four composites,…

  12. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    Science.gov (United States)

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four…

  13. Guide to the Successful Thesis and Dissertation: A Handbook for Students and Faculty, Fourth Edition, Revised and Expanded. Books in Library and Information Science Series.

    Science.gov (United States)

    Mauch, James E.; Birch, Jack W.

    This guide for graduate students and their supervising university faculty provides practical advice for writing and supervising the thesis or dissertation. The guide is based on input from interviews with more than 100 supervising faculty members as well as other sources. Among changes in this edition are an increased emphasis on the honors…

  14. Guide to the Successful Thesis and Dissertation: A Handbook for Students and Faculty, Fourth Edition, Revised and Expanded. Books in Library and Information Science Series.

    Science.gov (United States)

    Mauch, James E.; Birch, Jack W.

    This guide for graduate students and their supervising university faculty provides practical advice for writing and supervising the thesis or dissertation. The guide is based on input from interviews with more than 100 supervising faculty members as well as other sources. Among changes in this edition are an increased emphasis on the honors…

  15. A Four- and Five-Factor Structural Model for Wechsler Tests: Does It Really Matter Clinically?

    Science.gov (United States)

    Schwartz, David M.

    2013-01-01

    The purpose of this commentary is to focus on the clinical utility of the four- and five-factor structural models for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) and Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). It provides a discussion of important considerations when evaluating the clinical utility of the…

  16. A Four- and Five-Factor Structural Model for Wechsler Tests: Does It Really Matter Clinically?

    Science.gov (United States)

    Schwartz, David M.

    2013-01-01

    The purpose of this commentary is to focus on the clinical utility of the four- and five-factor structural models for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) and Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). It provides a discussion of important considerations when evaluating the clinical utility of the…

  17. The time factor in two Slovak editions of the novel El río oscuro by Alfredo Varela

    Directory of Open Access Journals (Sweden)

    Eva Palkovičová

    2012-12-01

    Full Text Available The aim of this study is to compare of two Slovak editions of the novel El río oscuro by the Argentinian writer Alfredo Varela. This novel was first published in Slovak in 1951 as a translation by Vladimír Oleríny and in 1968 was republished in a new edition with significant changes to the translation. Since we are dealing with two different editions of the same translation published in the span of 17 years, it is interesting to examine the influence of the time factor on the translation itself, the edition, revision and re-edition of this literary work. Following a comparative analysis of the two texts, we came to the conclusion that the edition from 1951 bears all hallmarks of a novice translator’s idiolect, however it also reflects the short tradition of translating from Spanish into Slovak. In the 1968 edition there is a marked change in the translator’s perspective, concerning, above all, the relation of ‘the foreign’ to ‘the domestic’. There also is a clearer and pronounced translation strategy, reflecting the abilities of an experienced translator, the development of the target language and the development of the Slovak theory of translation. It seems to us that the influence of the time factor is visible in both editions examined and, it would with no doubt manifest in a possible third edition of Oleríny’s translation, or, as the case may be, in another translation of Valera’s El río oscuro.

  18. APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo

    Science.gov (United States)

    Snyder, Elizabeth M.; McCarty, Christopher; Mehalow, Adrienne; Svenson, Karen L.; Murray, Stephen A.; Korstanje, Ron; Braun, Robert E.

    2017-01-01

    Editing of the human and murine ApoB mRNA by APOBEC1, the catalytic enzyme of the protein complex that catalyzes C-to-U RNA editing, creates an internal stop codon within the APOB coding sequence, generating two protein isoforms. It has been long held that APOBEC1-mediated editing activity is dependent on the RNA binding protein A1CF. The function of A1CF in adult tissues has not been reported because a previously reported null allele displays embryonic lethality. This work aimed to address the function of A1CF in adult mouse tissues using a conditional A1cf allele. Unexpectedly, A1cf-null mice were viable and fertile with modest defects in hematopoietic, immune, and metabolic parameters. C-to-U RNA editing was quantified for multiple targets, including ApoB, in the small intestine and liver. In all cases, no changes in RNA editing efficiency were observed. Blood plasma analysis demonstrated a male-specific increase in solute concentration and increased cellularity in the glomeruli of male A1cf-null mice. Urine analysis showed a reduction in solute concentration, suggesting abnormal water homeostasis and possible kidney abnormalities exclusive to the male. Computational identification of kidney C-to-U editing sites from polyadenylated RNA-sequencing identified a number of editing sites exclusive to the kidney. However, molecular analysis of kidney C-to-U editing showed no changes in editing efficiency with A1CF loss. Taken together, these observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggests new roles for A1CF, specifically within the male adult kidney. PMID:28069890

  19. APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.

    Science.gov (United States)

    Snyder, Elizabeth M; McCarty, Christopher; Mehalow, Adrienne; Svenson, Karen L; Murray, Stephen A; Korstanje, Ron; Braun, Robert E

    2017-04-01

    Editing of the human and murine ApoB mRNA by APOBEC1, the catalytic enzyme of the protein complex that catalyzes C-to-U RNA editing, creates an internal stop codon within the APOB coding sequence, generating two protein isoforms. It has been long held that APOBEC1-mediated editing activity is dependent on the RNA binding protein A1CF. The function of A1CF in adult tissues has not been reported because a previously reported null allele displays embryonic lethality. This work aimed to address the function of A1CF in adult mouse tissues using a conditional A1cf allele. Unexpectedly, A1cf-null mice were viable and fertile with modest defects in hematopoietic, immune, and metabolic parameters. C-to-U RNA editing was quantified for multiple targets, including ApoB, in the small intestine and liver. In all cases, no changes in RNA editing efficiency were observed. Blood plasma analysis demonstrated a male-specific increase in solute concentration and increased cellularity in the glomeruli of male A1cf-null mice. Urine analysis showed a reduction in solute concentration, suggesting abnormal water homeostasis and possible kidney abnormalities exclusive to the male. Computational identification of kidney C-to-U editing sites from polyadenylated RNA-sequencing identified a number of editing sites exclusive to the kidney. However, molecular analysis of kidney C-to-U editing showed no changes in editing efficiency with A1CF loss. Taken together, these observations demonstrate that A1CF does not act as the APOBEC1 complementation factor in vivo under normal physiological conditions and suggests new roles for A1CF, specifically within the male adult kidney.

  20. FACTORS THAT INFLUENCE IN SEDENTARY LIFESTYLE OF STUDENTS OF FOURTH CYCLE OF A PUBLIC HIGH SCHOOL

    Directory of Open Access Journals (Sweden)

    Carlos Álvarez Bogantes

    2015-08-01

    Full Text Available There is sufficient evidence to say that women as they move into the education system to reduce physical activity levels of sedentary lifestyle that put them at higher risk for non-communicable diseases. This led to determine the reasons for the inactivity of a group of fourth cycle. In order to address this problem, a qualitative design using focus groups and depth interviews was used, applied to30 women of high school participated. The results indicate that the participants are unaware of the benefits that can give them an active life, possibly affecting their movement behavior. A key element that have expressed is little impact of physical education classes when promoting lifestyles movement of the participants in this study, especially for ignoring the needs and barriers that students have. Become clear that the sport orientation of physical education classes and lack the skills to participate in activities successfully, sedentary activities of friends, the attitudes of parents; curriculum and lack of facilities also have significant impact in the studied group.

  1. Exploratory Factor Analysis of Diagnostic and Statistical Manual, 5th Edition, Criteria for Posttraumatic Stress Disorder.

    Science.gov (United States)

    McSweeney, Lauren B; Koch, Ellen I; Saules, Karen K; Jefferson, Stephen

    2016-01-01

    One change to the posttraumatic stress disorder (PTSD) nomenclature highlighted in the Diagnostic and Statistical Manual, 5th Edition (DSM-5; American Psychiatric Association, 2013) is the conceptualization of PTSD as a diagnostic category with four distinct symptom clusters. This article presents exploratory factor analysis to test the structural validity of the DSM-5 conceptualization of PTSD via an online survey that included the PTSD Checklist-5. The study utilized a sample of 113 college students from a large Midwestern university and 177 Amazon Mechanical Turk users. Participants were primarily female, Caucasian, single, and heterosexual with an average age of 32 years. Approximately 30% to 35% of participants met diagnostic criteria for PTSD based on two different scoring criteria. Results of the exploratory factor analysis revealed five distinct symptom clusters. The implications for the classification of PTSD are discussed.

  2. In vitro RNA-binding assay for studying trans-factors for RNA editing in chloroplasts.

    Science.gov (United States)

    Shikanai, Toshiharu; Okuda, Kenji

    2011-01-01

    In plant organelles, specific C residues are modified to U by RNA editing. Short RNA sequences surrounding the target site (i.e., cis-elements) are recognized by trans-factors, which were recently shown to be pentatricopeptide repeat (PPR) proteins. PPR proteins consist of tandem arrays of a highly degenerate unit of 35 (pentatrico) amino acids, and PPR motifs are believed to recognize specific RNA sequences. In Arabidopsis thaliana, more than 450 sites are edited in mitochondria and plastids, and a similar number of PPR proteins are encoded in the nuclear genome. To study how the tandem array of a PPR motif facilitates the recognition of RNA sequences, an efficient biochemical strategy is an in vitro binding assay of recombinant PPR proteins with target RNA. This analysis is especially powerful with a combination of in vivo analyses based on the phenotypes of mutants and transgenic plants. In this chapter, we describe methods for the expression of recombinant PPR proteins in Escherichia coli, preparation of probe RNAs, and RNA gel shift assays. These methods can also be utilized for other RNA-binding proteins.

  3. Investigating the structure and invariance of the Wechsler Adult Intelligence Scales, Fourth Edition in a sample of adults with intellectual disabilities.

    Science.gov (United States)

    Reynolds, Matthew R; Ingram, Paul B; Seeley, Jennifer S; Newby, Kaylee D

    2013-10-01

    Recent research has questioned whether the Wechsler Adult Intelligence Scales (WAIS) measure the same constructs for adults with intellectual disabilities as they do for the general population (MacLean et al., 2011). Using the special validity sample of the WAIS-IV (Wechsler, 2008b), the structure of the WAIS-IV was investigated using confirmatory factor analysis and tested for measurement invariance across a sample with intellectual disabilities and a control group matched in demographic characteristics. The instrument demonstrated strong factorial invariance when the standard subtests were used. When the standard and supplemental subtests were included in the model, the WAIS-IV four-factor structure provided a model of measurement for the Subtest Scores in the intellectual disability group, but the Perceptual Reasoning factor demonstrated differentiation into Fluid Reasoning and Visual-Spatial factors in the matched control group. In general, the research findings suggest that the four-factor structure of the WAIS-IV is invariant across the intellectual disability and matched control groups. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Fourth quantization

    Energy Technology Data Exchange (ETDEWEB)

    Faizal, Mir

    2013-12-18

    In this Letter we will analyze the creation of the multiverse. We will first calculate the wave function for the multiverse using third quantization. Then we will fourth-quantize this theory. We will show that there is no single vacuum state for this theory. Thus, we can end up with a multiverse, even after starting from a vacuum state. This will be used as a possible explanation for the creation of the multiverse. We also analyze the effect of interactions in this fourth-quantized theory.

  5. Fourth dimension of the nucleon structure: Spacetime analysis of the timelike electromagnetic proton form factors

    Science.gov (United States)

    Bianconi, Andrea; Tomasi-Gustafsson, Egle

    2017-01-01

    As is well known, spacelike proton form factors expressed in the Breit frame may be interpreted as the Fourier transform of static space distributions of electric charge and current. In particular, the electric form factor is simply the Fourier transform of the charge distribution F (q ) =∫ei q ⃗.r ⃗ρ (r ) d3r . We do not have an intuitive interpretation of the same level of simplicity for the proton timelike form factor appearing in the reactions e+e-↔p ¯p . However, one may suggest that, in the center-of-mass frame, where qμxμ=q t , a timelike electric form factor is the Fourier transform F (q ) =∫ei q tR (t ) d t of a function R (t ) expressing how the electric properties of the forming (or annihilating) proton-antiproton pair evolve in time. Here we analyze in depth this idea and show that the functions ρ (r ) and R (t ) can be formally written as the time and space integrals of a unique correlation function depending on both time and space coordinates.

  6. The fourth dimension of the nucleon structure: spacetime analysis of the timelike electromagnetic proton form factors

    CERN Document Server

    Bianconi, Andrea

    2016-01-01

    As well known, spacelike proton form factors expressed in the Breit frame may be interpreted as the Fourier transform of static space distributions of electric charge and current. In particular, the electric form factor is simply the Fourier transform of the charge distribution $F(q)=\\int e^{i\\vec q \\cdot \\vec r} \\rho(r)d^3r$. We don't have an intuitive interpretation of the same level of simplicity for the proton timelike form factor appearing in the reactions $e^+e^-\\leftrightarrow \\bar{p}p$. However, one may suggest that in the center of mass (CM) frame, where $q_\\mu x^\\mu =qt$, a timelike electric form factor is the Fourier transform $F(q) =\\int e^{iqt} R(t)dt$ of a function $R(t)$ expressing how the electric properties of the forming (or annihilating) proton-antiproton pair evolve in time. Here we analyze in depth this idea, show that the functions $\\rho(r)$ and $R(t)$ can be formally written as the time and space integrals of a unique correlation function depending on both time and space coordinates.

  7. A Confirmatory Factor Analysis of the California Verbal Learning Test-Second Edition (CVLT-II) in the Standardization Sample

    Science.gov (United States)

    Donders, Jacobus

    2008-01-01

    The purpose of this study is to determine the latent structure of the California Verbal Learning Test-Second Edition (CVLT-II; Delis, Kramer, Kaplan, & Ober, 2000) at three different age levels, using the standardization sample. Maximum likelihood confirmatory factor analyses are performed to test four competing hypothetical models for fit and…

  8. A Confirmatory Factor Analysis of the California Verbal Learning Test-Second Edition (CVLT-II) in the Standardization Sample

    Science.gov (United States)

    Donders, Jacobus

    2008-01-01

    The purpose of this study is to determine the latent structure of the California Verbal Learning Test-Second Edition (CVLT-II; Delis, Kramer, Kaplan, & Ober, 2000) at three different age levels, using the standardization sample. Maximum likelihood confirmatory factor analyses are performed to test four competing hypothetical models for fit and…

  9. Learning string edit distance

    CERN Document Server

    Ristad, E S; Ristad, Eric Sven; Yianilos, Peter N.

    1996-01-01

    In many applications, it is necessary to determine the similarity of two strings. A widely-used notion of string similarity is the edit distance: the minimum number of insertions, deletions, and substitutions required to transform one string into the other. In this report, we provide a stochastic model for string edit distance. Our stochastic model allows us to learn a string edit distance function from a corpus of examples. We illustrate the utility of our approach by applying it to the difficult problem of learning the pronunciation of words in conversational speech. In this application, we learn a string edit distance with one fourth the error rate of the untrained Levenshtein distance. Our approach is applicable to any string classification problem that may be solved using a similarity function against a database of labeled prototypes. Keywords: string edit distance, Levenshtein distance, stochastic transduction, syntactic pattern recognition, prototype dictionary, spelling correction, string correction, ...

  10. A proposed method to estimate premorbid full scale intelligence quotient (FSIQ) for the Canadian Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) using demographic and combined estimation procedures.

    Science.gov (United States)

    Schoenberg, Mike R; Lange, Rael T; Saklofske, Donald H

    2007-11-01

    Establishing a comparison standard in neuropsychological assessment is crucial to determining change in function. There is no available method to estimate premorbid intellectual functioning for the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV). The WISC-IV provided normative data for both American and Canadian children aged 6 to 16 years old. This study developed regression algorithms as a proposed method to estimate full-scale intelligence quotient (FSIQ) for the Canadian WISC-IV. Participants were the Canadian WISC-IV standardization sample (n = 1,100). The sample was randomly divided into two groups (development and validation groups). The development group was used to generate regression algorithms; 1 algorithm only included demographics, and 11 combined demographic variables with WISC-IV subtest raw scores. The algorithms accounted for 18% to 70% of the variance in FSIQ (standard error of estimate, SEE = 8.6 to 14.2). Estimated FSIQ significantly correlated with actual FSIQ (r = .30 to .80), and the majority of individual FSIQ estimates were within +/-10 points of actual FSIQ. The demographic-only algorithm was less accurate than algorithms combining demographic variables with subtest raw scores. The current algorithms yielded accurate estimates of current FSIQ for Canadian individuals aged 6-16 years old. The potential application of the algorithms to estimate premorbid FSIQ is reviewed. While promising, clinical validation of the algorithms in a sample of children and/or adolescents with known neurological dysfunction is needed to establish these algorithms as a premorbid estimation procedure.

  11. Analysis on the chapter of rehabilitation definition in the fourth edition of rehabilitation medicine textbook%对《康复医学》第4版教材中康复定义一节的分析

    Institute of Scientific and Technical Information of China (English)

    张弘; 江园; 李飞

    2013-01-01

    康复的定义应该反映其在康复医学体系中的内涵和外延,因其系外来名词,在翻译推广过程中需要特别注意.《康复医学》(人民卫生出版社,第4版)教材中康复定义一节在康复定义方面综合国外权威定义时欠准确,“再学习”概念引入未考虑前后衔接,使教师在课堂上对于《康复医学》的讲解以及学生的理解均较为困难.此外在康复医学术语使用方面也有待商榷.%The definition of rehabilitation should reflect the connotation and extension of rehabilitation medicine system,moreover,special attention should be paid to the process of translation,applications and promotion due to its derivation from Latin.The fourth edition of rehabilitation medicine textbook which published by People's Medical Publishing House described the definition of rehabilitation inaccurately,although integrated the foreign authority definitions.The definition of ‘ re-learning’has been described by the textbook without considering logical sequence,which caused difficulty in explaining and comprehending between teachers and students in class.Besides,application of another term of rehabilitation medicine in the textbook is imprudence.

  12. Military Display Market: Fourth Comprehensive Edition

    Science.gov (United States)

    2006-02-01

    Operations Center ( SPOC ) Web Server monitors are DELL. The Autodin Message Distribution Terminal (AMDT) is by TOUCH. The Enhanced Command Console...goggles. 9. ACKNOWLEDGEMENTS We thank the DOD Program Offices, Logistics Centers, and industrial partners that provided information over the course of this

  13. Special Operations Forces Reference Manual. Fourth Edition

    Science.gov (United States)

    2015-06-01

    operational leverage by gathering critical information, undermining a potential adversary’s will or capacity to wage war, and enhancing the...Wingspan 132 ft., 7 in. (40.4m) Speed 300 mph (480 kph) Ceiling 33,000 ft. (10,000m) Load 75 troops or 50 paratroopers Max Takeoff Weight 155,000 pounds...130J Commando II Length 97 ft., 9 in (29.3m) Height 38 ft., 10 in. (11.9m) Wingspan 132 ft., 7 in. (40.4m) Speed 362 KTAS Ceiling 28,000 ft. Load 75

  14. Effective Teaching: Preparation and Implementation. Fourth Edition

    Science.gov (United States)

    Hunt, Gilbert H.; Wiseman, Dennis G.; Touzel, Timothy J.

    2009-01-01

    Schools today have transcended from the chalkboard to the whiteboard and are populated by students who are not frightened to use the technology of this new age of learning. During this period of dynamic change, teachers must be ready to meet the challenges of preparing students for a global society characterized by diversity and ever-increasing…

  15. Manatees: An Educator's Guide. Fourth Edition.

    Science.gov (United States)

    Save the Manatee Club, Maitland, FL.

    The manatee is known for its gentleness and uniqueness and has become a symbol of human concern for endangered species. This guide provides current information on the West Indian manatee as well as strategies for teaching about this endangered animal. While focusing on the manatee, this guide points out the importance of interdependencies within…

  16. Disease Vector Ecology Profile: Somalia. Fourth Edition

    Science.gov (United States)

    1993-09-15

    resistance have been reported from Somalia. Those reports available indicate that Aedes aegypti is resistant to diazinon but is susceptible to other...B. E. et al. 1968. Yellow fever immunity surveys in northern Uganda and Kenya and eastern Somalia, 1966-67. WHO Bull. 38(2): 229-37 (19 ref

  17. Adlerian Counseling: A Practitioner's Approach. Fourth Edition.

    Science.gov (United States)

    Sweeney, Thomas J.

    Written with the practitioner in mind, this overview of the theory and practice of Alfred Adler's Individual Psychology explains the dimensions and uses of natural and logical consequences--the twin bases of Adlerian/Individual Psychology. The text takes a practical approach to the topic, and covers a variety of settings (school, home, community,…

  18. Adlerian Counseling: A Practitioner's Approach. Fourth Edition.

    Science.gov (United States)

    Sweeney, Thomas J.

    Written with the practitioner in mind, this overview of the theory and practice of Alfred Adler's Individual Psychology explains the dimensions and uses of natural and logical consequences--the twin bases of Adlerian/Individual Psychology. The text takes a practical approach to the topic, and covers a variety of settings (school, home, community,…

  19. Sexual dimorphism in ratio of second and fourth digits and its relationship with metabolic syndrome indices and cardiovascular risk factors

    Directory of Open Access Journals (Sweden)

    Bolaji Fatai Oyeyemi

    2014-01-01

    Full Text Available Background: Ratio of second and fourth digit (2D:4D is known to be germane in analyzing utero concentrations of testosterone and estrogen in human and other vertebrates. 2D:4D had been linked to several traits like athletes′ abilities, reproductive success, risk of cancer and cardiovascular disease (CVD. Metabolic syndrome (MetS is a clustering of several cardiovascular risk factors. Waist circumference (WC, neck circumference (NC, body mass index (BMI and waist-to-height ratio (WHtR are important in measuring MetS. This study investigated sexual dimorphism in 2D:4D and its relationship with MetS indices and CVD factors among adult residing in Ilorin, North central Nigeria. Materials and Methods: This is a cross-sectional, stratified multi-staged sampling study. Participants residing in different neighborhoods were visited at home where finger lengths and anthropometric traits were measured. Participants include 801 healthy adults aged 18-44 years (56% male who had been living in the area for more than 3 years. Results: Males showed significantly lower 2D:4D than females (unpaired t-test; t [699] = 11.49, P = 0.001. A significant positive correlation was observed in MetS markers and 2D:4D. WHtR showed the highest correlation with 2D:4D in male (r = 0.461, P ≤ 0.001 and female (r = 0.408, P ≤ 0.001 when compared with BMI, NC and WC. All positive correlations recorded in this study were high in male and right hand. Conclusion: Our results showed that 2D:4D is sexual dimorphic and right hand 2D:4D as a predictor of MetS is better. We concluded that 2D:4D is a proxy for MetS and CVD risk factors in Ilorin.

  20. A survey of PPR proteins identifies DYW domains like those of land plant RNA editing factors in diverse eukaryotes

    OpenAIRE

    Schallenberg-Rüdinger, Mareike; Lenz, Henning; Polsakiewicz, Monika; Gott, Jonatha M.; Knoop, Volker

    2013-01-01

    The pentatricopeptide repeat modules of PPR proteins are key to their sequence-specific binding to RNAs. Gene families encoding PPR proteins are greatly expanded in land plants where hundreds of them participate in RNA maturation, mainly in mitochondria and chloroplasts. Many plant PPR proteins contain additional carboxyterminal domains and have been identified as essential factors for specific events of C-to-U RNA editing, which is abundant in the two endosymbiotic plant organelles. Among th...

  1. A survey of PPR proteins identifies DYW domains like those of land plant RNA editing factors in diverse eukaryotes.

    Science.gov (United States)

    Schallenberg-Rüdinger, Mareike; Lenz, Henning; Polsakiewicz, Monika; Gott, Jonatha M; Knoop, Volker

    2013-01-01

    The pentatricopeptide repeat modules of PPR proteins are key to their sequence-specific binding to RNAs. Gene families encoding PPR proteins are greatly expanded in land plants where hundreds of them participate in RNA maturation, mainly in mitochondria and chloroplasts. Many plant PPR proteins contain additional carboxyterminal domains and have been identified as essential factors for specific events of C-to-U RNA editing, which is abundant in the two endosymbiotic plant organelles. Among those carboxyterminal domain additions to plant PPR proteins, the so-called DYW domain is particularly interesting given its similarity to cytidine deaminases. The frequency of organelle C-to-U RNA editing and the diversity of DYW-type PPR proteins correlate well in plants and both were recently identified outside of land plants, in the protist Naegleria gruberi. Here we present a systematic survey of PPR protein genes and report on the identification of additional DYW-type PPR proteins in the protists Acanthamoeba castellanii, Malawimonas jakobiformis, and Physarum polycephalum. Moreover, DYW domains were also found in basal branches of multi-cellular lineages outside of land plants, including the alga Nitella flexilis and the rotifers Adineta ricciae and Philodina roseola. Intriguingly, the well-characterized and curious patterns of mitochondrial RNA editing in the slime mold Physarum also include examples of C-to-U changes. Finally, we identify candidate sites for mitochondrial RNA editing in Malawimonas, further supporting a link between DYW-type PPR proteins and C-to-U editing, which may have remained hitherto unnoticed in additional eukaryote lineages.

  2. A survey of PPR proteins identifies DYW domains like those of land plant RNA editing factors in diverse eukaryotes

    Science.gov (United States)

    Schallenberg-Rüdinger, Mareike; Lenz, Henning; Polsakiewicz, Monika; Gott, Jonatha M; Knoop, Volker

    2013-01-01

    The pentatricopeptide repeat modules of PPR proteins are key to their sequence-specific binding to RNAs. Gene families encoding PPR proteins are greatly expanded in land plants where hundreds of them participate in RNA maturation, mainly in mitochondria and chloroplasts. Many plant PPR proteins contain additional carboxyterminal domains and have been identified as essential factors for specific events of C-to-U RNA editing, which is abundant in the two endosymbiotic plant organelles. Among those carboxyterminal domain additions to plant PPR proteins, the so-called DYW domain is particularly interesting given its similarity to cytidine deaminases. The frequency of organelle C-to-U RNA editing and the diversity of DYW-type PPR proteins correlate well in plants and both were recently identified outside of land plants, in the protist Naegleria gruberi. Here we present a systematic survey of PPR protein genes and report on the identification of additional DYW-type PPR proteins in the protists Acanthamoeba castellanii, Malawimonas jakobiformis, and Physarum polycephalum. Moreover, DYW domains were also found in basal branches of multi-cellular lineages outside of land plants, including the alga Nitella flexilis and the rotifers Adineta ricciae and Philodina roseola. Intriguingly, the well-characterized and curious patterns of mitochondrial RNA editing in the slime mold Physarum also include examples of C-to-U changes. Finally, we identify candidate sites for mitochondrial RNA editing in Malawimonas, further supporting a link between DYW-type PPR proteins and C-to-U editing, which may have remained hitherto unnoticed in additional eukaryote lineages. PMID:23899506

  3. Solar Energy Technologies Program Newsletter - Fourth Quarter 2009

    Energy Technology Data Exchange (ETDEWEB)

    DOE Solar Energy Technologies Program

    2009-12-31

    The Fourth Quarter 2009 edition of the Solar Energy Technologies Program newsletter summarizes the activities for the past three months, funding opportunities, highlights from the national labs, and upcoming events.

  4. Reproducing the Wechsler Intelligence Scale for Children-Fifth Edition: Factor Model Results

    Science.gov (United States)

    Beaujean, A. Alexander

    2016-01-01

    One of the ways to increase the reproducibility of research is for authors to provide a sufficient description of the data analytic procedures so that others can replicate the results. The publishers of the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V) do not follow these guidelines when reporting their confirmatory factor…

  5. The relationship between five-factor model and diagnostic and statistical manual of mental disorder-fifth edition personality traits on patients with antisocial personality disorder

    Directory of Open Access Journals (Sweden)

    Mahdi Amini

    2015-01-01

    Full Text Available Background: Despite the fact that new criteria of antisocial personality disorder (ASPD in diagnostic and statistical manual of mental disorders-fifth edition (DSM-5 were resulted from five-factor model (FFM, there is a small amount of studies that investigate the relations between proposed personality traits and FFM. Also, cross-cultural study in this field continuously would be needed. The aim of the present study was to evaluate the relation between the FFM and DSM-5 ASPD pathological traits. Materials and Methods: This study was a cross-sectional study design. The participants consisted of 122 individuals with ASPD that selected from prisoners (73.0%, outpatients (18.0%, and inpatients (9.0%. They were recruited from Tehran Prisoners, and Clinical Psychology and Psychiatry Clinics of Razi and Taleghani Hospitals, Tehran, Iran, since 2013-2014. The Sample was selected based on judgmental sampling. The structured clinical interview for DSM-IV axis II disorders-Personality Questionnaire, NEO-Personality Inventory-Revised, and DSM-5 personality trait rating form were used to diagnosis and assessment of personality disorder. Pearson correlation has been used for data analysis. All statistical analyses were performed using the SPSS 16 software. Results: The results indicate that neuroticism (N has positive significant relationship with hostility (r = 0.33, P < 0.01, manipulativeness (r = 0.25, P < 0.01, deceitfulness (r =.23, P < 0.01, impulsivity (r = 0.20, P < 0.05, and negative relation with risk taking (r = −0.23, P < 0.01. Also, there was significant relationship between extraversion (E with manipulativeness (r = 0.28, P < 0.01 and deceitfulness (r = 0.32, P < 0.01. Agreeableness and conscientiousness have negative significant relation with DSM-5 traits. In addition, results showed that there is positive significant relationship between FFM and DSM-5 personality traits with DSM-fourth edition-text revision (DSM-IV-TR ASPD symptoms (P < 0

  6. The factor structure, metrical properties, and convergent validity of the third edition (1999 of the locus of control inventory

    Directory of Open Access Journals (Sweden)

    Johann M Schepers

    2006-02-01

    Full Text Available The principal objective of the study was to examine the factor structure and metrical properties of the third edition (1999 of the Locus of Control Inventory (LCI. A corollary of the study was to examine the convergent validity of the instrument. After a thorough revision and extension of the scale to 88 items it was applied to a sample of 2091 first-year university students. Particular attention was paid to the shortcomings revealed in a study by de Bruin (2004. An iterative principal factor analysis of the scale was done. The three-factor-structure previously found was substantiated by the analysis. The obtained factors were interpreted as Autonomy, External Control and Internal Control. Highly acceptable reliabilities were obtained. As far as validity is concerned it was found that Internal Control and Autonomy are strongly related to Psychological Wellness and External Control negatively to Stress Management. The implications of the findings are discussed.

  7. Family Life: Literature and Films. An Annotated Bibliography. Supplement to Fourth Revision.

    Science.gov (United States)

    Pitzer, Ronald L., Ed.

    This supplement to the fourth edition of "Family Life Literature and Films: An Annotated Bibliography" includes materials produced since the publication of the fourth edition (see AC 012 492). The materials are listed under nine topic headings, as follows: I. The American Family: Theoretical, Historical, and Subcultural Perspectives; II. Human…

  8. A Confirmatory Analysis of the Factor Structure and Cross-Age Invariance of the Wechsler Adult Intelligence Scale-Third Edition

    Science.gov (United States)

    Taub, Gordon E.; McGrew, Kevin S.; Witta, E. Lea

    2004-01-01

    In the Wechsler Adult Intelligence Scale-Third Edition (WAIS-III; D. Wechsler, 1997), the manual reports several confirmatory factor analyses in support of the instrument's latent factor structure. In practice, examiners frequently compare an examinee's score from a current administration of the WAIS-III with the results from a previous test…

  9. Site-specific factor involved in the editing of the psbL mRNA in tobacco plastids.

    OpenAIRE

    1995-01-01

    In tobacco plastids, functional psbL mRNA is created by editing an ACG codon to an AUG translation initiation codon. To determine if editing may occur in a chimeric mRNA, the N-terminal part of psbL containing the editing site was translationally fused with the aadA and kan bacterial genes. The chimeric constructs were introduced into the tobacco plastid genome by targeted gene insertion. Editing of the chimeric mRNAs indicated that the 98 nt fragment spanning the psbL editing site contains a...

  10. Distinctions without a Difference: The Utility of Observed versus Latent Factors from the WISC-IV in Estimating Reading and Math Achievement on the WIAT-II

    Science.gov (United States)

    Glutting, Joseph J.; Watkins, Marley W.; Konold, Timothy R.; McDermott, Paul A.

    2006-01-01

    This study employed observed factor index scores as well as latent ability constructs from the "Wechsler Intelligence Scale for Children-Fourth Edition" (WISC-IV; Wechsler, 2003) in estimating reading and mathematics achievement on the "Wechsler Individual Achievement Test-Second Edition" (WIAT-II; Wechsler, 2002). Participants…

  11. Factor structure of the Wechsler Intelligence Scale for Children-Fifth Edition: Exploratory factor analyses with the 16 primary and secondary subtests.

    Science.gov (United States)

    Canivez, Gary L; Watkins, Marley W; Dombrowski, Stefan C

    2016-08-01

    The factor structure of the 16 Primary and Secondary subtests of the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V; Wechsler, 2014a) standardization sample was examined with exploratory factor analytic methods (EFA) not included in the WISC-V Technical and Interpretive Manual (Wechsler, 2014b). Factor extraction criteria suggested 1 to 4 factors and results favored 4 first-order factors. When this structure was transformed with the Schmid and Leiman (1957) orthogonalization procedure, the hierarchical g-factor accounted for large portions of total and common variance while the 4 first-order factors accounted for small portions of total and common variance; rendering interpretation at the factor index level less appropriate. Although the publisher favored a 5-factor model where the Perceptual Reasoning factor was split into separate Visual Spatial and Fluid Reasoning dimensions, no evidence for 5 factors was found. It was concluded that the WISC-V provides strong measurement of general intelligence and clinical interpretation should be primarily, if not exclusively, at that level. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  12. Incremental Validity of WISC-IV[superscript UK] Factor Index Scores with a Referred Irish Sample: Predicting Performance on the WIAT-II[superscript UK

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.; James, Trevor; Good, Rebecca; James, Kate

    2014-01-01

    Background: Subtest and factor scores have typically provided little incremental predictive validity beyond the omnibus IQ score. Aims: This study examined the incremental validity of Wechsler Intelligence Scale for Children-Fourth UK Edition (WISC-IV[superscript UK]; Wechsler, 2004a, "Wechsler Intelligence Scale for Children-Fourth UK…

  13. Incremental Validity of WISC-IV[superscript UK] Factor Index Scores with a Referred Irish Sample: Predicting Performance on the WIAT-II[superscript UK

    Science.gov (United States)

    Canivez, Gary L.; Watkins, Marley W.; James, Trevor; Good, Rebecca; James, Kate

    2014-01-01

    Background: Subtest and factor scores have typically provided little incremental predictive validity beyond the omnibus IQ score. Aims: This study examined the incremental validity of Wechsler Intelligence Scale for Children-Fourth UK Edition (WISC-IV[superscript UK]; Wechsler, 2004a, "Wechsler Intelligence Scale for Children-Fourth UK…

  14. 2015版犠犎犗肺肿瘤组织学分类解读%Fourth edition of WHO classification of tumours of the lung,published in 2015

    Institute of Scientific and Technical Information of China (English)

    陈真伟; 滕晓东

    2016-01-01

    To compare 4th edition of WHO Classification of Tumours of the Lung (published in 2015)and 3rd edi-tion (published in 2004)and review relevant literature.The 4th edition not only incorporated a great number of changes but also newly added 6 tumors entities,ie:NUT carcinoma,myoepithelial tumours,pulmonary myxoid sarcoma with EWSR1-CREB1 translocation,intravascular large B-cell lymphoma,Erdheim-Chester disease,Meningioma NOS,as well as updated the contents of molecular pathology and immunohistochemistry of lung cancer,emphasizing detection of lung cancer relate genes and targeted therapies,renamed some of the tumours,for example,sclerosing haemangioma replaced by sclerosing pneumocytoma,using the term lepidic adenocarcinoma for formerly bronchioloalveolar carcinoma.%对第4版(2015年)WHO 肺肿瘤分类与第3版(2004年)肿瘤分类进行比较,并复习相关文献。2015版肿瘤分类作了大量的改动,对肺肿瘤的分类做了一些修改,新增了6个病种,即 NUT 中线癌、肌上皮肿瘤、伴有 EWSR1-CREB1基因易位的肺黏液样肉瘤、血管内大 B 细胞淋巴瘤、Erdheim-Chester 病和脑膜瘤非特异型;更新了肺癌的分子病理和免疫组织化学等内容,强调了肺癌相关基因的检测与靶向治疗。对一些肿瘤作了重新命名,如硬化性血管瘤命名为硬化性肺泡细胞瘤,使用贴壁型腺癌代替原先的细支气管肺泡癌。

  15. Factor structure of the Beck Depression Inventory-Second Edition (BDI-II) with Puerto Rican elderly.

    Science.gov (United States)

    Rodríguez-Gómez, José R; Dávila-Martínez, Mariel G; Collazo-Rodríguez, Luis C

    2006-06-01

    The Beck Depression Inventory-Second Edition (BDI-II; (1) is one of the most useful measures for depressive symptomatology in many countries (2). The psychometric properties of this inventory, however, have not been reported with Puerto Rican elderly. This paper reports, exploratory psychometric results with a sample of 410 elderly Puerto Rican (65 years and older; men=94, women=316). The assessment of the construct validity of the BDI-II yielded four factors accounting for 52% of total variance and an internal reliability coefficient (alpha Cronbach) of .89. A factor analysis with the 21 items of the BDI-II was performed using principal component analysis as the extraction method and Varimax rotation. This analysis revealed that the BDI-II was a good measure of the dimensions of depressive symptomatology in the present sample, which resembled prior findings reported with the general Puerto Rican Population (3). This study also reports further data supporting the reliability, validity, and practical utility of the BDI-II for the Puerto Rican population including elders. Implications for potential research with minorities and clinical uses of the BDI-II are also discussed.

  16. 76 FR 61098 - Exposure Factors Handbook: 2011 Edition; Release of Final Report

    Science.gov (United States)

    2011-10-03

    ... and soil adherence factors; consumption of fruits and vegetables, fish, meats, dairy products, and... National Center for Environmental Assessment (NCEA) within EPA's Office of Research and Development. The... the Recent Additions and Publications menus at http://www.epa.gov/ncea . Paper copies of the report...

  17. Evidence-based editing: factors influencing the number of citations in a national journal.

    Science.gov (United States)

    Ruano-Ravina, Alberto; Alvarez-Dardet, Carlos

    2012-09-01

    Citations received by papers published within a journal serve to increase its bibliometric impact. The objective of this paper was to assess the influence of publication language, article type, number of authors, and year of publication on the citations received by papers published in Gaceta Sanitaria, a Spanish-language journal of public health. The information sources were the journal website and the Web of Knowledge, of the Institute of Scientific Information. The period analyzed was from 2007 to 2010. We included original articles, brief original articles, and reviews published within that period. We extracted manually information regarding the variables analyzed and we also differentiated among total citations and self-citations. We constructed logistic regression models to analyze the probability of a Gaceta Sanitaria paper to be cited or not, taking into account the aforementioned independent variables. We also analyzed the probability of receiving citations from non-Spanish authors. Two hundred forty papers fulfilled the inclusion criteria. The included papers received a total of 287 citations, which became 202 when excluding self-citations. The only variable influencing the probability of being cited was the publication year. After excluding never cited papers, time since publication and review papers had the highest probabilities of being cited. Papers in English and review articles had a higher probability of citation from non-Spanish authors. Publication language has no influence on the citations received by a national, non-English journal. Reviews in English have the highest probability of citation from abroad. Editors should decide how to manage this information when deciding policies to raise the bibliometric impact factor of their journals. Copyright © 2012 Elsevier Inc. All rights reserved.

  18. Psychological Status and Associated Factors among Korean Cancer Survivors: a Cross-Sectional Analysis of the Fourth & Fifth Korea National Health and Nutrition Examination Surveys.

    Science.gov (United States)

    Choi, Kyung-Hyun; Park, Sang Min

    2016-07-01

    It is important to assess psychological distress after a diagnosis for cancer survivors, a population with a high risk for psychological distress. The aim of this study is to assess psychological distress among cancer survivors and to clarify the associated factors. In this cross-sectional analysis, data were obtained from standardized questionnaires administered to 1,163 cancer survivors and 49,243 non-cancer survivors who participated in the Fourth and Fifth Korea National Health and Nutrition Examination Survey (2007-2012). We identified the adjusted rates for psychological distress and assessed factors associated with this kind of distress using multivariate logistic regression. Cancer survivors tended to have a higher adjusted rate of psychological distress than the general population. The current depressive symptom rate for cancer survivors was 16.69%, and the adjusted rate for history of depression in cancer survivors was 15.61%. The adjusted rate for higher level of stress was 25.51% in cancer survivors. Among the cancer survivors, younger subjects, female subjects, and those with limited social support were more prone to psychological distress. In addition, current smokers or risky drinkers, those with chronic diseases, and those with a poor self-perception of their health status were also identified as a high-risk group for psychological distress. As the number of cancer survivors has increased, the importance of assessing psychological distress after a cancer diagnosis should be emphasized among all cancer survivors. Further, psychological supportive care interventions for cancer survivors are needed to improve the survival rate and improve their quality of life.

  19. The fourth dimension

    CERN Document Server

    Rucker, Rudy

    2014-01-01

    ""This is an invigorating book, a short but spirited slalom for the mind."" - Timothy Ferris, The New York Times Book Review ""Highly readable. One is reminded of the breadth and depth of Hofstadter's Gödel, Escher, Bach."" - Science""Anyone with even a minimal interest in mathematics and fantasy will find The Fourth Dimension informative and mind-dazzling... [Rucker] plunges into spaces above three with a zest and energy that is breathtaking."" - Martin Gardner ""Those who think the fourth dimension is nothing but time should be encouraged to read The Fourth Dimension, along with anyone else

  20. Cluster editing

    DEFF Research Database (Denmark)

    Böcker, S.; Baumbach, Jan

    2013-01-01

    . The problem has been the inspiration for numerous algorithms in bioinformatics, aiming at clustering entities such as genes, proteins, phenotypes, or patients. In this paper, we review exact and heuristic methods that have been proposed for the Cluster Editing problem, and also applications......The Cluster Editing problem asks to transform a graph into a disjoint union of cliques using a minimum number of edge modifications. Although the problem has been proven NP-complete several times, it has nevertheless attracted much research both from the theoretical and the applied side...

  1. Multilinguals and Wikipedia Editing

    CERN Document Server

    Hale, Scott A

    2013-01-01

    This article analyzes one month of edits to Wikipedia in order to examine the role of users editing multiple language editions (referred to as multilingual users). Such multilingual users may serve an important function in diffusing information across different language editions of the project, and prior work has suggested this could reduce the level of self-focus bias in each edition. This study finds multilingual users are much more active than their single-edition (monolingual) counterparts. They are found in all language editions, but smaller-sized editions with fewer users have a higher percentage of multilingual users than larger-sized editions. About a quarter of multilingual users always edit the same articles in multiple languages, while just over 40% of multilingual users edit different articles in different languages. When non-English users do edit a second language edition, that edition is most frequently English. Nonetheless, several regional and linguistic cross-editing patterns are also present...

  2. Orthogonal Higher Order Structure of the WISC-IV Spanish Using Hierarchical Exploratory Factor Analytic Procedures

    Science.gov (United States)

    McGill, Ryan J.; Canivez, Gary L.

    2016-01-01

    As recommended by Carroll, the present study examined the factor structure of the Wechsler Intelligence Scale for Children-Fourth Edition Spanish (WISC-IV Spanish) normative sample using higher order exploratory factor analytic techniques not included in the WISC-IV Spanish Technical Manual. Results indicated that the WISC-IV Spanish subtests were…

  3. Confirmatory Factor Analysis of the WISC-IV in a Hospital Referral Sample

    Science.gov (United States)

    Devena, Sarah E.; Gay, Catherine E.; Watkins, Marley W.

    2013-01-01

    Confirmatory factor analysis was used to determine the factor structure of the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) scores of 297 children referred to a children's hospital in the Southwestern United States. Results support previous findings that indicate the WISC-IV is best represented by a direct hierarchical…

  4. Orthogonal Higher Order Structure of the WISC-IV Spanish Using Hierarchical Exploratory Factor Analytic Procedures

    Science.gov (United States)

    McGill, Ryan J.; Canivez, Gary L.

    2016-01-01

    As recommended by Carroll, the present study examined the factor structure of the Wechsler Intelligence Scale for Children-Fourth Edition Spanish (WISC-IV Spanish) normative sample using higher order exploratory factor analytic techniques not included in the WISC-IV Spanish Technical Manual. Results indicated that the WISC-IV Spanish subtests were…

  5. Biomass Energy Data Book: Edition 4

    Energy Technology Data Exchange (ETDEWEB)

    Boundy, Robert Gary [ORNL; Diegel, Susan W [ORNL; Wright, Lynn L [ORNL; Davis, Stacy Cagle [ORNL

    2011-12-01

    The Biomass Energy Data Book is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Biomass Program in the Energy Efficiency and Renewable Energy (EERE) program of the Department of Energy (DOE). Designed for use as a convenient reference, the book represents an assembly and display of statistics and information that characterize the biomass industry, from the production of biomass feedstocks to their end use, including discussions on sustainability. This is the fourth edition of the Biomass Energy Data Book which is only available online in electronic format. There are five main sections to this book. The first section is an introduction which provides an overview of biomass resources and consumption. Following the introduction to biomass, is a section on biofuels which covers ethanol, biodiesel and bio-oil. The biopower section focuses on the use of biomass for electrical power generation and heating. The fourth section is on the developing area of biorefineries, and the fifth section covers feedstocks that are produced and used in the biomass industry. The sources used represent the latest available data. There are also two appendices which include frequently needed conversion factors, a table of selected biomass feedstock characteristics, and discussions on sustainability. A glossary of terms and a list of acronyms are also included for the reader's convenience.

  6. Classroom Management: Sound Theory and Effective Practice. Fourth Edition

    Science.gov (United States)

    Tauber, Robert T.

    2007-01-01

    Educators need a balance between discipline theory and its practice in the classroom. This is especially important in today's educational climate, with its increased demands for teacher accountability. Tauber has designed this book for both those who are new to teaching and those who are already seasoned teachers, but who have had little, if any,…

  7. Thompson and Thompson genetics in medicine. Fourth edition

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, M.

    1986-01-01

    This book provides coverage of the basic principles and clinical role of genetics. It also emphasizes new developments in molecular genetics as applied to medicine and features expanded coverage of pre-natal issues, recombinant DNA, gene mapping - plus new information on genetically based clinical syndromes such as ''Fragile X Syndrome,'' a common cause of mental retardation.

  8. Neutron capture cross section standards for BNL 325, Fourth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Holden, N.E.

    1981-01-01

    This report evaluates the experimental data and recommends values for the thermal neutron cross sections and resonance integrals for the neutron capture reactions: /sup 55/Mn(n,..gamma..), /sup 59/Co(n,..gamma..) and /sup 197/Au(n,..gamma..). The failure of lithium and boron as standards due to the natural variation of the absorption cross sections of these elements is discussed. The Westcott convention, which describes the neutron spectrum as a thermal Maxwellian distribution with an epithermal component, is also discussed.

  9. Ethical Responsibility in Communication: A Selected, Annotated Bibliography. Fourth Edition.

    Science.gov (United States)

    Johannesen, Richard L.

    Representing works published between 1970 and 1984, this annotated bibliography identifies a variety of readings that explore fundamental issues of ethics in interpersonal, public, and mass communication, and that examine from an ethical viewpoint how to and whether to employ particular communication tactics or techniques. The bibliography…

  10. Educators Guide to Free Filmstrips. Twenty-Fourth Edition.

    Science.gov (United States)

    Horkheimer, Mary Foley, Comp.; Diffor, John C., Comp.

    More than 450 filmstrips for teaching a wide range of educational topics which are available to schools in the U.S. without charge are listed in this catalog. The filmstrips are classified into 17 topics, including agriculture, arts and crafts, business education, driver education, environmental education, geography, history, home economics,…

  11. The Principalship: A Reflective Practice Perspective. Fourth Edition.

    Science.gov (United States)

    Sergiovanni, Thomas J.

    This book addresses the concepts, values, principles, and practices of the principalship. Its five major themes are as follows: (1) toward a new theory; (2) providing leadership; (3) building community; (4) the development of human resources; and (5) the moral dimension. Chapter titles reflect its contents: (1) "Views of the Principal's…

  12. Planning for an Individual Water System. Fourth Edition Revised.

    Science.gov (United States)

    Turner, J. Howard, Ed.

    Few investments have as little thought given to planning as the installation of a water-supply system for the home or farm. There are many considerations to be made if an adequate supply of water is to be available for the living and recreational needs of a family or the needs of livestock. This book is designed to instruct the reader on how to…

  13. Leadership for Recreation, Parks, and Leisure Services. Fourth Edition

    Science.gov (United States)

    Edginton, Christopher R.; Hudson, Susan D.; Scholl, Kathleen G.; Lauzon, Lara

    2011-01-01

    "Leadership for Recreation, Parks and Leisure Services" presents new perspectives on the importance of leadership in the profession. Integrating theory with practice, the book provides foundational perspectives in the study of leadership at all levels--direct service, supervisory, managerial and community/civic--in recreation, parks and leisure…

  14. The Principalship: A Reflective Practice Perspective. Fourth Edition.

    Science.gov (United States)

    Sergiovanni, Thomas J.

    This book addresses the concepts, values, principles, and practices of the principalship. Its five major themes are as follows: (1) toward a new theory; (2) providing leadership; (3) building community; (4) the development of human resources; and (5) the moral dimension. Chapter titles reflect its contents: (1) "Views of the Principal's…

  15. Law and society [Review] Steven Vago (Fourth Edition: 1994)

    OpenAIRE

    Ghouri, Ahmad

    2012-01-01

    My primary interest in Sociology of Law is to analyse the interconnection between social and legal orders, and understand how the socio-legal environment reflects and influences different legal structures. I take up Vago’s book “Law & Society” with this avowed purpose, and also to refine, or perhaps to realign, my sociological imagination. I am also interested to learn research techniques employed in the socio-legal context, and possible uses of such techniques in the area of law I work in. T...

  16. MOPAC Manual. A General Molecular Orbital Package. Fourth Edition.

    Science.gov (United States)

    1987-10-01

    when I DENOUT was specified. This affects MOPAC running on Gould, Cray I and other computers. I 2. Masamoto Togashi, Jerzy M. Rudzinski, Zdenek...DCART - PRINT DETAiL- (F WORKING IN DCART DEBUG - DEBUG OPTION TURNED ON DEBUGPULAY PRINT DETAILS OF WORKING IN PULAY DENOUT - DENSITY MATRIX OUTPUT...debugging ITER. DEBUG can also increase the amount of output produced when certain output keywords are used, e.g. COMPFG. DENOUT (0) The density matrix

  17. The Supervisor and On-the-Job Training. Fourth Edition.

    Science.gov (United States)

    Broadwell, Martin M.

    This training book is designed to help supervisors give accurate and effective on-the-job training (OJT) to employees under their supervision. Chapter 1 identifies good and bad training and good and bad reasons for training. Chapter 2 examines human learning and three motivators: desire for reward, fear of punishment, and curiosity. Chapter 3…

  18. Directory of Federally Supported Information Analysis Centers, 1979. Fourth Edition.

    Science.gov (United States)

    1979-01-01

    controlled by (DASIAC) Headquarters, DNA . General Electric Tempo 816 State St. SERVICES: Provides consulting and advisory Santa Barbara, Calif. 93102...makes materials available to qualified users; assists in organizing, announcing, and conducting SPONSOR: Defense Nuclear Agency ( DNA ). seminars...and Greenland flora; Antarctic lichen mission to visit the Center should be addressed to and plant fossil collections. the Security Office of the

  19. Understanding Emergent Readers and Writers. Custom Edition for the Ohio Summer Institute for Reading Intervention, Summer 2001.

    Science.gov (United States)

    Morrow, Lesley Mandel; McGee, Lea M.; Richgels, Donald J.

    This book, a custom edition for the Ohio Summer Institute for Reading Intervention (Summer 2001), reprints selected chapters from two books, "Literacy Development in the Early Years: Helping Children Read and Write," Fourth Edition (Lesley Mandel Morrow) and "Literacy's Beginnings: Supporting Young Readers and Writers," Third Edition (Lea M. McGee…

  20. FOURTH REVIEW OF TESTS PUBLISHED IN SPAIN: FORM AND CONTENT

    Directory of Open Access Journals (Sweden)

    Paula Elosua

    2016-05-01

    Full Text Available Assessing the quality of tests and disseminating the results has been implemented in the international arena with the aim of improving testing and professional practice. Assessing tests provides users with an independent review, which follows clearly defined procedures and criteria. In Spain, the Spanish Association of Psychology (COP leads the “test evaluation” project, which has recently completed its fourth edition. Basically, there are two primary assessment models; the Buros model and the European Federation of Psychologists’ Associations (EFPA model, which has been adopted by the COP. The two models share the same objectives and content; excluding the evaluation format and the management system, they are similar in essence. In this paper, we present the results of the fourth edition of the Spanish test evaluation program following the general guidelines for assessing the quality of tests, and we explain the critical points affecting each phase of the process

  1. The Arabidopsis thaliana RNA Editing FactorSLO2, which Affects the Mitochondrial ElectronTransport Chain, Participates in Multiple Stressand Hormone Resoonses

    Institute of Scientific and Technical Information of China (English)

    2014-01-01

    Recently, we reported that the novel mitochondrial RNA editing factor SLO2 is essential for mitochondrialelectron transport, and vital for plant growth through regulation of carbon and energy metabolism. Here, we show thatmutation in SL02 causes hypersensitivity to ABA and insensitivity to ethylene, suggesting a link with stress responses.Indeed, slo2 mutants are hypersensitive to salt and osmotic stress during the germination stage, while adult plantsshow increased drought and salt tolerance. Moreover, slo2 mutants are more susceptible to Botrytis cinerea infection.An increased expression of nuclear-encoded stress-responsive genes, as well as mitochondrial-encoded NAD genes ofcomplex I and genes of the alternative respiratory pathway, was observed in slo2 mutants, further enhanced by ABAtreatment. In addition, H202 accumulation and altered amino acid levels were recorded in slo2 mutants. We conclude thatSLO2 is required for plant sensitivity to ABA, ethylene, biotic, and abiotic stress. Although two stress-related RNA editingfactors were reported very recently, this study demonstrates a unique role of SLO2, and further supports a link betweenmitochondrial RNA editing events and stress response.

  2. Fourth Generation War: Paradigm for Change

    Science.gov (United States)

    2005-06-01

    frustrated by the advantages that the weak acquire through 4GW, are also within the genre of the Fourth Generation. Terrorism is the strategy and tactic of...for SF. In order to examine these factors a brief overview of SF is necessary. 1. What Makes the SOF As per the techno-- thriller author Tom

  3. Structural validity of the Wechsler Intelligence Scale for Children-Fifth Edition: Confirmatory factor analyses with the 16 primary and secondary subtests.

    Science.gov (United States)

    Canivez, Gary L; Watkins, Marley W; Dombrowski, Stefan C

    2017-04-01

    The factor structure of the Wechsler Intelligence Scale for Children-Fifth Edition (WISC-V; Wechsler, 2014a) standardization sample (N = 2,200) was examined using confirmatory factor analyses (CFA) with maximum likelihood estimation for all reported models from the WISC-V Technical and Interpretation Manual (Wechsler, 2014b). Additionally, alternative bifactor models were examined and variance estimates and model-based reliability estimates (ω coefficients) were provided. Results from analyses of the 16 primary and secondary WISC-V subtests found that all higher-order CFA models with 5 group factors (VC, VS, FR, WM, and PS) produced model specification errors where the Fluid Reasoning factor produced negative variance and were thus judged inadequate. Of the 16 models tested, the bifactor model containing 4 group factors (VC, PR, WM, and PS) produced the best fit. Results from analyses of the 10 primary WISC-V subtests also found the bifactor model with 4 group factors (VC, PR, WM, and PS) produced the best fit. Variance estimates from both 16 and 10 subtest based bifactor models found dominance of general intelligence (g) in accounting for subtest variance (except for PS subtests) and large ω-hierarchical coefficients supporting general intelligence interpretation. The small portions of variance uniquely captured by the 4 group factors and low ω-hierarchical subscale coefficients likely render the group factors of questionable interpretive value independent of g (except perhaps for PS). Present CFA results confirm the EFA results reported by Canivez, Watkins, and Dombrowski (2015); Dombrowski, Canivez, Watkins, and Beaujean (2015); and Canivez, Dombrowski, and Watkins (2015). (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  4. Ebola virus RNA editing depends on the primary editing site sequence and an upstream secondary structure.

    Directory of Open Access Journals (Sweden)

    Masfique Mehedi

    Full Text Available Ebolavirus (EBOV, the causative agent of a severe hemorrhagic fever and a biosafety level 4 pathogen, increases its genome coding capacity by producing multiple transcripts encoding for structural and nonstructural glycoproteins from a single gene. This is achieved through RNA editing, during which non-template adenosine residues are incorporated into the EBOV mRNAs at an editing site encoding for 7 adenosine residues. However, the mechanism of EBOV RNA editing is currently not understood. In this study, we report for the first time that minigenomes containing the glycoprotein gene editing site can undergo RNA editing, thereby eliminating the requirement for a biosafety level 4 laboratory to study EBOV RNA editing. Using a newly developed dual-reporter minigenome, we have characterized the mechanism of EBOV RNA editing, and have identified cis-acting sequences that are required for editing, located between 9 nt upstream and 9 nt downstream of the editing site. Moreover, we show that a secondary structure in the upstream cis-acting sequence plays an important role in RNA editing. EBOV RNA editing is glycoprotein gene-specific, as a stretch encoding for 7 adenosine residues located in the viral polymerase gene did not serve as an editing site, most likely due to an absence of the necessary cis-acting sequences. Finally, the EBOV protein VP30 was identified as a trans-acting factor for RNA editing, constituting a novel function for this protein. Overall, our results provide novel insights into the RNA editing mechanism of EBOV, further understanding of which might result in novel intervention strategies against this viral pathogen.

  5. Biomass Energy Data Book: Edition 2

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Lynn L [ORNL; Boundy, Robert Gary [ORNL; Badger, Philip C [ORNL; Perlack, Robert D [ORNL; Davis, Stacy Cagle [ORNL

    2009-12-01

    The Biomass Energy Data Book is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Biomass Program in the Energy Efficiency and Renewable Energy (EERE) program of the Department of Energy (DOE). Designed for use as a convenient reference, the book represents an assembly and display of statistics and information that characterize the biomass industry, from the production of biomass feedstocks to their end use, including discussions on sustainability. This is the second edition of the Biomass Energy Data Book which is only available online in electronic format. There are five main sections to this book. The first section is an introduction which provides an overview of biomass resources and consumption. Following the introduction to biomass, is a section on biofuels which covers ethanol, biodiesel and bio-oil. The biopower section focuses on the use of biomass for electrical power generation and heating. The fourth section is on the developing area of biorefineries, and the fifth section covers feedstocks that are produced and used in the biomass industry. The sources used represent the latest available data. There are also four appendices which include frequently needed conversion factors, a table of selected biomass feedstock characteristics, assumptions for selected tables and figures, and discussions on sustainability. A glossary of terms and a list of acronyms are also included for the reader's convenience.

  6. Biomass Energy Data Book: Edition 3

    Energy Technology Data Exchange (ETDEWEB)

    Boundy, Robert Gary [ORNL; Davis, Stacy Cagle [ORNL

    2010-12-01

    The Biomass Energy Data Book is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Biomass Program in the Energy Efficiency and Renewable Energy (EERE) program of the Department of Energy (DOE). Designed for use as a convenient reference, the book represents an assembly and display of statistics and information that characterize the biomass industry, from the production of biomass feedstocks to their end use, including discussions on sustainability. This is the third edition of the Biomass Energy Data Book which is only available online in electronic format. There are five main sections to this book. The first section is an introduction which provides an overview of biomass resources and consumption. Following the introduction to biomass, is a section on biofuels which covers ethanol, biodiesel and bio-oil. The biopower section focuses on the use of biomass for electrical power generation and heating. The fourth section is on the developing area of biorefineries, and the fifth section covers feedstocks that are produced and used in the biomass industry. The sources used represent the latest available data. There are also four appendices which include frequently needed conversion factors, a table of selected biomass feedstock characteristics, and discussions on sustainability. A glossary of terms and a list of acronyms are also included for the reader's convenience.

  7. Transportation energy data book: Edition 13

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.; Strang, S.G.

    1993-03-01

    The Transportation Energy Data Book: Edition 13 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. Each of the major transportation modes -- highway, air, water, rail, pipeline -- is treated in separate chapters or sections. Chapter 1 compares US transportation data with data from seven other countries. Aggregate energy use and energy supply data for all modes are presented in Chapter 2. The highway mode, which accounts for over three-fourths of total transportation energy consumption, is dealt with in Chapter 3. Topics in this chapter include automobiles, trucks, buses, fleet automobiles, federal standards, fuel economies, and vehicle emission data. Household travel behavior characteristics are displayed in Chapter 4. Chapter 5 contains information on alternative fuels and alternatively-fueled vehicles. The last chapter, Chapter 6, covers each of the nonhighway modes: air, water, pipeline, and rail, respectively.

  8. Transportation energy data book: Edition 12

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.; Morris, M.D.

    1992-03-01

    The Transportation Energy Data Book: Edition 12 is a statistical compendium prepared and published by Oak Ridge National Laboratory under contract with the Office of Transportation Technologies in the Department of Energy. Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. Each of the major transportation modes--highway, air, water, rail, pipeline--is treated in separate chapters or sections. Chapter 1 compares US transportation data with data from seven other countries. Aggregate energy use and energy supply data for all modes are presented in Chapter 2. The highway mode, which accounts for over three-fourths of total transportation energy consumption, is dealt with in Chapter 3. Topics in this chapter include automobiles, trucks, buses, fleet automobiles, federal standards, fuel economies, and vehicle emission data. Household travel behavior characteristics are displayed in Chapter 4. Chapter 5 contains information on alternative fuels and alternatively-fueled vehicles. The last chapter, Chapter 6, covers each of the nonhighway modes: air, water, pipeline, and rail, respectively.

  9. Transportation energy data book: edition 16

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C. [Lockheed Martin Energy Systems, Inc., Oak Ridge, TN (United States); McFarlin, D.N. [Tennessee Univ., Knoxville, TN (United States)

    1996-07-01

    The Transportation Energy Data Book: Edition 16 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. Each of the major transportation modes is treated in separate chapters or sections. Chapter 1 compares U.S. transportation data with data from other countries. Aggregate energy use and energy supply data for all modes are presented in Chapter 2. The highway mode, which accounts for over three-fourths of total transportation energy consumption, is dealt with in Chapter 3. Topics in this chapter include automobiles, trucks, buses, fleet vehicles, federal standards, fuel economies, and high- occupancy vehicle lane data. Household travel behavior characteristics are displayed in Chapter 4. Chapter 5 contains information on alternative fuels and alternative fuel vehicles. Chapter 6 covers the major nonhighway modes: air, water, and rail. The last chapter, Chapter 7, presents data on environmental issues relating to transportation.

  10. Transportation energy data book: Edition 15

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    1995-05-01

    The Transportation Energy Data Book: Edition 15 is a statistical compendium. Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. Purpose of this document is to present relevant statistical data in the form of tables and graphs. Each of the major transportation modes is treated in separate chapters or sections. Chapter I compares US transportation data with data from other countries. Aggregate energy use and energy supply data for all modes are presented in Chapter 2. The highway mode, which accounts for over three-fourths of total transportation energy consumption, is dealt with in Chapter 3. Topics in this chapter include automobiles, trucks, buses, fleet vehicles, federal standards, fuel economies, and high-occupancy vehicle lane data. Household travel behavior characteristics are displayed in Chapter 4. Chapter 5 contains information on alternative fuels and alternative fuel vehicles. Chapter 6 covers the major nonhighway modes: air, water, and rail. The last chapter, Chapter 7, presents data environmental issues relating to transportation.

  11. Transportation energy data book: Edition 13

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.; Strang, S.G.

    1993-03-01

    The Transportation Energy Data Book: Edition 13 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. Each of the major transportation modes - highway, air, water, rail, pipeline - is treated in separate chapters or sections. Chapter 1 compares US transportation data with data from seven other countries. Aggregate energy use and energy supply data for all modes are presented in Chapter 2. The highway mode, which accounts for over three-fourths of total transportation energy consumption, is dealt with in Chapter 3. Topics in this chapter include automobiles, trucks, buses, fleet automobiles, federal standards, fuel economies, and vehicle emission data. Household travel behavior characteristics are displayed in Chapter 4. Chapter 5 contains information on alternative fuels and alternatively-fueled vehicles. The last chapter, Chapter 6, covers each of the nonhighway modes: air, water, pipeline, and rail, respectively.

  12. Transportation energy data book: Edition 12

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.; Morris, M.D.

    1992-03-01

    The Transportation Energy Data Book: Edition 12 is a statistical compendium prepared and published by Oak Ridge National Laboratory under contract with the Office of Transportation Technologies in the Department of Energy. Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. Each of the major transportation modes--highway, air, water, rail, pipeline--is treated in separate chapters or sections. Chapter 1 compares US transportation data with data from seven other countries. Aggregate energy use and energy supply data for all modes are presented in Chapter 2. The highway mode, which accounts for over three-fourths of total transportation energy consumption, is dealt with in Chapter 3. Topics in this chapter include automobiles, trucks, buses, fleet automobiles, federal standards, fuel economies, and vehicle emission data. Household travel behavior characteristics are displayed in Chapter 4. Chapter 5 contains information on alternative fuels and alternatively-fueled vehicles. The last chapter, Chapter 6, covers each of the nonhighway modes: air, water, pipeline, and rail, respectively.

  13. 海洛因依赖者《美国精神障碍诊断与统计手册(第四版)》轴Ⅰ障碍的终身患病情况分析%Axis Ⅰ comorbidity of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders among heroin-dependent patients

    Institute of Scientific and Technical Information of China (English)

    杨梅; 廖艳辉; 王强; 王红; Vasish Kavi; 刘铁桥; 郝伟

    2013-01-01

    Objective To provide lifetime rates of axis Ⅰ conorbidities of the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) among patients with heroin dependence.Methods A cross-section study was conducted.Subjects were 1002 heroin-dependent patients who were consecutively admitted into three drug rehabilitation settings in Hunan province.A questionnaire was developed to get demographic and drug use-related information of the subjects.Structured Clinical Interview for DSM-IV-TR Axis Ⅰ Disorders-Patient Edition (SCID-I/P) was used for making lifetime DSM-Ⅳ axis Ⅰ diagnoses.Results Among the subjects,mood disorder was the most common type of cooccurring axis Ⅰ non-substance use mental disorders (191,19.1%),followed by anxiety disorder (128,12.8%).Major depression (135,13.5%) was the most common diagnosis among co-occurring mood disorders,whereas post-traumatic stress disorder (PTSD,81,8.1%) was the most common diagnosis among anxiety disorders.579 (57.8%) subjects had other substance (non-opioid,other than tobacco) use disorders.The most frequent diagnoses of other substance use disorders were sedative-hypnotics use disorder and alcohol use disorder,with lifetime rates of 30.3% (303) and 27.5% (275) respectively,followed by stimulant and hallucinogen use disorder,with a lifetime rate of 14.8% (148) for stimulant use disorder and a lifetime rate of 12.7% (127) for hallucinogen use disorder.Conclusions Co-occurring non-substance use mental disorders and other substance use disorders among heroin-dependent patients in China are highly prevalent,to which great importance should be attached in the process of diagnosis and treatment.%目的 调查我国海洛因依赖者中《美国精神障碍诊断与统计手册(第4版)》(DSM-Ⅳ)轴Ⅰ精神障碍和其他物质使用障碍的终身患病情况.方法 对湖南省3家戒毒机构的1002例海洛因依赖者进行横截面调查;采用自制调查表收集一

  14. Soft Drink Design - USMES Teacher Resource Book. Fourth Edition. Trial Edition.

    Science.gov (United States)

    Agro, Sally; Sampson, Sue Scott

    Inventing a new soft drink that is popular and can be produced at low cost is the challenge of this Unified Sciences and Mathematics for Elementary Schools (USMES) unit. The challenge is general enough to apply to many problem-solving situations in mathematics, science, social science, and language arts at any elementary school level (grades 1-8).…

  15. Edit wars in Wikipedia

    CERN Document Server

    Sumi, Róbert; Rung, András; Kornai, András; Kertész, János

    2011-01-01

    We present a new, efficient method for automatically detecting severe conflicts `edit wars' in Wikipedia and evaluate this method on six different language WPs. We discuss how the number of edits, reverts, the length of discussions, the burstiness of edits and reverts deviate in such pages from those following the general workflow, and argue that earlier work has significantly over-estimated the contentiousness of the Wikipedia editing process.

  16. Multiplex editing system

    DEFF Research Database (Denmark)

    2015-01-01

    The present invention relates to a multiplex editing system. The system allows multiple editing of nucleic acid sequences such as genomic sequences, such as knockins of genes of interest in a genome, knockouts of genomic sequences and/or allele replacement. Also provided herein are a method...... for editing nucleic acids and a cell comprising a stably integrated endonuclease....

  17. Health Behaviors and Risk Factors Associated with Chronic Kidney Disease in Korean Patients with Diabetes: The Fourth Korean National Health and Nutritional Examination Survey

    Directory of Open Access Journals (Sweden)

    Suk Jeong Lee, PhD, RN

    2014-03-01

    Conclusion: Since renal functions are affected by lifestyle factors, it is critical for healthcare professionals to provide diabetic patients with health education focused on changing their behavior so that it is conducive to health. It is also necessary to consider that diabetes education should be made more available and provided more effectively to these patients.

  18. The brain-derived neurotrophic factor (BDNF) val66met polymorphism differentially affects performance on subscales of the Wechsler Memory Scale - Third Edition (WMS-III).

    Science.gov (United States)

    Lamb, Yvette N; Thompson, Christopher S; McKay, Nicole S; Waldie, Karen E; Kirk, Ian J

    2015-01-01

    Single nucleotide polymorphisms in the brain-derived neurotrophic factor (BDNF) gene and the catechol-O-methyltransferase (COMT) gene influence brain structure and function, as well as cognitive abilities. They are most influential in the hippocampus and prefrontal cortex (PFC), respectively. Recall and recognition are forms of memory proposed to have different neural substrates, with recall having a greater dependence on the PFC and hippocampus. This study aimed to determine whether the BDNF val(66)met or COMT val(158)met polymorphisms differentially affect recall and recognition, and whether these polymorphisms interact. A sample of 100 healthy adults was assessed on recall and familiarity-based recognition using the Faces and Family Pictures subscales of the Wechsler Memory Scale - Third Edition (WMS-III). COMT genotype did not affect performance on either task. The BDNF polymorphism (i.e., met carriers relative to val homozygotes) was associated with poorer recall ability, while not influencing recognition. Combining subscale scores in memory tests such as the WMS might obscure gene effects. Our results demonstrate the importance of distinguishing between recall and familiarity-based recognition in neurogenetics research.

  19. The brain-derived neurotrophic factor (BDNF val66met polymorphism differentially affects performance on subscales of the Wechsler memory scale – third edition (WMS-III

    Directory of Open Access Journals (Sweden)

    Yvette Nicole Lamb

    2015-08-01

    Full Text Available Single nucleotide polymorphisms in the brain-derived neurotrophic factor (BDNF gene and the catechol-O-methyltransferase (COMT gene influence brain structure and function, as well as cognitive abilities. They are most influential in the hippocampus and prefrontal cortex (PFC, respectively. Recall and recognition are forms of memory proposed to have different neural substrates, with recall having a greater dependence on the PFC and hippocampus. This study aimed to determine whether the BDNF val66met or COMT val158met polymorphisms differentially affect recall and recognition, and whether these polymorphisms interact. A sample of 100 healthy adults was assessed on recall and familiarity-based recognition using the Faces and Family Pictures subscales of the Wechsler Memory Scale – Third Edition (WMS-III. COMT genotype did not affect performance on either task. The BDNF polymorphism (i.e. met carriers relative to val homozygotes was associated with poorer recall ability, while not influencing recognition. Combining subscale scores in memory tests such as the WMS might obscure gene effects. Our results demonstrate the importance of distinguishing between recall and familiarity-based recognition in neurogenetics research.

  20. Factors Associated with Diabetic Retinopathy and Nephropathy Screening in Korea: The Third and Fourth Korea National Health and Nutrition Examination Survey (KNHANES III and IV)

    OpenAIRE

    Rim, Tyler Hyung Taek; Byun, Il Hwan; Kim, Han Sang; Lee, Sang Yeul; Yoon, Jin Sook

    2013-01-01

    This cross-sectional study was done to identify and determine the socio-demographic and health-related factors associated with diabetic retinopathy and nephropathy screening in Korea. Participants included 2,660 adults, aged 40 or older, with diabetes. Of the 2,660 adults, 998 (37%) and 1,226 (46.1%) had received a diabetic retinopathy and a nephropathy screening within one year, respectively. Regarding retinopathy, subjects older than 65, living in urban areas, with high educational levels, ...

  1. Fourth Order Theories Without Ghosts

    CERN Document Server

    Mannheim, P D; Mannheim, Philip D.; Davidson, Aharon

    2000-01-01

    Using the Dirac constraint method we show that the pure fourth-order Pais-Uhlenbeck oscillator model is free of observable negative norm states. Even though such ghosts do appear when the fourth order theory is coupled to a second order one, the limit in which the second order action is switched off is found to be a highly singular one in which these states move off shell. Given this result, construction of a fully unitary, renormalizable, gravitational theory based on a purely fourth order action in 4 dimensions now appears feasible.

  2. Prevalence and risk factors of visual impairment and blindness in Korea: the Fourth Korea National Health and Nutrition Examination Survey in 2008-2010.

    Science.gov (United States)

    Rim, Tyler H T; Nam, Jae S; Choi, Moonjung; Lee, Sung C; Lee, Christopher S

    2014-06-01

    To describe the age, gender specific prevalence and risk factors of visual impairment and blindness in Korea. From 2008 to 2010, a total 14 924 randomly selected national representative participants of the Korea National Health and Nutrition Examination Survey underwent additional ophthalmologic examinations by the Korean Ophthalmologic Society. Best Corrected Distance Visual Acuity was measured using an international standard vision chart based on Snellen scale (Jin's vision chart). Independent risk factors for visual impairment were investigated using multivariate logistic regression analysis. The overall prevalence of visual impairment (≤20/40) of adults 40 years and older was 4.1% (95% CI, 3.6-4.6) based on the better seeing eye. The overall prevalence of blindness (≤20/200) for adults 40 years and older was 0.2% (95% CI, 0.1-0.3). Risk indicators of visual impairment were increasing age, low education status, living in rural area, being unemployed, being without spouse and the absence of private health insurance. The visually impaired were more likely to have eye diseases compared with the normal subjects, and they were less likely to utilize eye care. The prevalence of visual impairment was demonstrated to be higher while that of blindness was similar to previous population studies in Asia or U.S. Sociodemographic disparities are present in the prevalence of visual impairment and more targeted efforts are needed to promote vision screening in high risk groups. © 2014 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.

  3. Fourth Light at Paranal!

    Science.gov (United States)

    2000-09-01

    VLT YEPUN Joins ANTU, KUEYEN and MELIPAL It was a historical moment last night (September 3 - 4, 2000) in the VLT Control Room at the Paranal Observatory , after nearly 15 years of hard work. Finally, four teams of astronomers and engineers were sitting at the terminals - and each team with access to an 8.2-m telescope! From now on, the powerful "Paranal Quartet" will be observing night after night, with a combined mirror surface of more than 210 m 2. And beginning next year, some of them will be linked to form part of the unique VLT Interferometer with unparalleled sensitivity and image sharpness. YEPUN "First Light" Early in the evening, the fourth 8.2-m Unit Telescope, YEPUN , was pointed to the sky for the first time and successfully achieved "First Light". Following a few technical exposures, a series of "first light" photos was made of several astronomical objects with the VLT Test Camera. This instrument was also used for the three previous "First Light" events for ANTU ( May 1998 ), KUEYEN ( March 1999 ) and MELIPAL ( January 2000 ). These images served to evaluate provisionally the performance of the new telescope, mainly in terms of mechanical and optical quality. The ESO staff were very pleased with the results and pronounced YEPUN fit for the subsequent commissioning phase. When the name YEPUN was first given to the fourth VLT Unit Telescope, it was supposed to mean "Sirius" in the Mapuche language. However, doubts have since arisen about this translation and a detailed investigation now indicates that the correct meaning is "Venus" (as the Evening Star). For a detailed explanation, please consult the essay On the Meaning of "YEPUN" , now available at the ESO website. The first images At 21:39 hrs local time (01:39 UT), YEPUN was turned to point in the direction of a dense Milky Way field, near the border between the constellations Sagitta (The Arrow) and Aquila (The Eagle). A guide star was acquired and the active optics system quickly optimized the

  4. Developing new levels of edit

    Energy Technology Data Exchange (ETDEWEB)

    Prono, J.; DeLanoy, M.; Deupree, R.; Skiby, J.; Thompson, B.

    1998-07-01

    In 1985, the writing and editing group at Los Alamos National Laboratory established four levels of edit for technical reports. When a survey in 1994 showed that both authors and editors felt the levels were not meeting author needs, the authors set about revising them. Their goals were to simplify the editing process, focus editing on improving technical clarity, and ensure that value was added in editing. This paper describes the revision process and product -- three author-based levels of edit.

  5. A Confirmatory Factor Analysis of the California Verbal Learning Test-Second Edition (CVLT-II) in a Traumatic Brain Injury Sample

    Science.gov (United States)

    DeJong, Joy; Donders, Jacobus

    2009-01-01

    The latent structure of the California Verbal Learning Test-Second Edition (CVLT-II) was examined in a clinical sample of 223 persons with traumatic brain injury that had been screened to remove individuals with complicating premorbid (e.g., psychiatric) or comorbid (e.g., financial compensation seeking) histories. Analyses incorporated the…

  6. Digital Video Editing

    Science.gov (United States)

    McConnell, Terry

    2004-01-01

    Monica Adams, head librarian at Robinson Secondary in Fairfax country, Virginia, states that librarians should have the technical knowledge to support projects related to digital video editing. The process of digital video editing and the cables, storage issues and the computer system with software is described.

  7. Quality text editing

    Directory of Open Access Journals (Sweden)

    Gyöngyi Bujdosó

    2009-10-01

    Full Text Available Text editing is more than the knowledge of word processing techniques. Originally typographers, printers, text editors were the ones qualified to edit texts, which were well structured, legible, easily understandable, clear, and were able to emphasize the coreof the text. Time has changed, and nowadays everyone has access to computers as well as to text editing software and most users believe that having these tools is enough to edit texts. However, text editing requires more skills. Texts appearing either in printed or inelectronic form reveal that most of the users do not realize that they are not qualified to edit and publish their works. Analyzing the ‘text-products’ of the last decade a tendency can clearly be drawn. More and more documents appear, which instead of emphasizingthe subject matter, are lost in the maze of unstructured text slices. Without further thoughts different font types, colors, sizes, strange arrangements of objects, etc. are applied. We present examples with the most common typographic and text editing errors. Our aim is to call the attention to these mistakes and persuadeusers to spend time to educate themselves in text editing. They have to realize that a well-structured text is able to strengthen the effect on the reader, thus the original message will reach the target group.

  8. Comprehensive high-resolution analysis of the role of an Arabidopsis gene family in RNA editing.

    Directory of Open Access Journals (Sweden)

    Stéphane Bentolila

    2013-06-01

    Full Text Available In flowering plants, mitochondrial and chloroplast mRNAs are edited by C-to-U base modification. In plant organelles, RNA editing appears to be generally a correcting mechanism that restores the proper function of the encoded product. Members of the Arabidopsis RNA editing-Interacting Protein (RIP family have been recently shown to be essential components of the plant editing machinery. We report the use of a strand- and transcript-specific RNA-seq method (STS-PCRseq to explore the effect of mutation or silencing of every RIP gene on plant organelle editing. We confirm RIP1 to be a major editing factor that controls the editing extent of 75% of the mitochondrial sites and 20% of the plastid C targets of editing. The quantitative nature of RNA sequencing allows the precise determination of overlapping effects of RIP factors on RNA editing. Over 85% of the sites under the influence of RIP3 and RIP8, two moderately important mitochondrial factors, are also controlled by RIP1. Previously uncharacterized RIP family members were found to have only a slight effect on RNA editing. The preferential location of editing sites controlled by RIP7 on some transcripts suggests an RNA metabolism function for this factor other than editing. In addition to a complete characterization of the RIP factors for their effect on RNA editing, our study highlights the potential of RNA-seq for studying plant organelle editing. Unlike previous attempts to use RNA-seq to analyze RNA editing extent, our methodology focuses on sequencing of organelle cDNAs corresponding to known transcripts. As a result, the depth of coverage of each editing site reaches unprecedented values, assuring a reliable measurement of editing extent and the detection of numerous new sites. This strategy can be applied to the study of RNA editing in any organism.

  9. Comprehensive high-resolution analysis of the role of an Arabidopsis gene family in RNA editing.

    Science.gov (United States)

    Bentolila, Stéphane; Oh, Julyun; Hanson, Maureen R; Bukowski, Robert

    2013-06-01

    In flowering plants, mitochondrial and chloroplast mRNAs are edited by C-to-U base modification. In plant organelles, RNA editing appears to be generally a correcting mechanism that restores the proper function of the encoded product. Members of the Arabidopsis RNA editing-Interacting Protein (RIP) family have been recently shown to be essential components of the plant editing machinery. We report the use of a strand- and transcript-specific RNA-seq method (STS-PCRseq) to explore the effect of mutation or silencing of every RIP gene on plant organelle editing. We confirm RIP1 to be a major editing factor that controls the editing extent of 75% of the mitochondrial sites and 20% of the plastid C targets of editing. The quantitative nature of RNA sequencing allows the precise determination of overlapping effects of RIP factors on RNA editing. Over 85% of the sites under the influence of RIP3 and RIP8, two moderately important mitochondrial factors, are also controlled by RIP1. Previously uncharacterized RIP family members were found to have only a slight effect on RNA editing. The preferential location of editing sites controlled by RIP7 on some transcripts suggests an RNA metabolism function for this factor other than editing. In addition to a complete characterization of the RIP factors for their effect on RNA editing, our study highlights the potential of RNA-seq for studying plant organelle editing. Unlike previous attempts to use RNA-seq to analyze RNA editing extent, our methodology focuses on sequencing of organelle cDNAs corresponding to known transcripts. As a result, the depth of coverage of each editing site reaches unprecedented values, assuring a reliable measurement of editing extent and the detection of numerous new sites. This strategy can be applied to the study of RNA editing in any organism.

  10. Fandom and the fourth wall

    Directory of Open Access Journals (Sweden)

    Jenna Kathryn Ballinger

    2014-09-01

    Full Text Available I use the Teen Wolf fandom as an example to examine the ways social media has created a more complicated, nuanced relationship with fans. The collapse of the fourth wall between fans and The Powers That Be can have both positive and negative impacts, depending on the willingness of participants to maintain mutual respect and engage in meaningful dialogue.

  11. Modeling Individual Subtests of the WAIS IV with Multiple Latent Factors: e74980

    National Research Council Canada - National Science Library

    Dennis J McFarland

    2013-01-01

    ... multidimensional models of the Wechsler Adult Intelligence Scales- fourth edition (WAIS-IV) subtests. Multidimensional models of subtest performance provided better model fit as compared to several...

  12. Modeling individual subtests of the WAIS IV with multiple latent factors

    National Research Council Canada - National Science Library

    McFarland, Dennis J

    2013-01-01

    ... multidimensional models of the Wechsler Adult Intelligence Scales-fourth edition (WAIS-IV) subtests. Multidimensional models of subtest performance provided better model fit as compared to several...

  13. Cutaneous Squamous Cell Carcinoma: Review of the Eighth Edition of the American Joint Committee on Cancer Staging Guidelines, Prognostic Factors, and Histopathologic Variants.

    Science.gov (United States)

    Motaparthi, Kiran; Kapil, Jyoti P; Velazquez, Elsa F

    2017-07-01

    Cutaneous squamous cell carcinoma is the second most common form of nonmelanoma skin cancer after basal cell carcinoma and accounts for the majority of nonmelanoma skin cancer-related deaths. In 2017, the American Joint Committee on Cancer revised the staging guidelines of cutaneous squamous cell carcinoma to reflect recent evidence concerning high-risk clinicopathologic features. This update reviews the literature on prognostic features and staging, including the eighth edition of the American Joint Committee on Cancer Staging Manual. A wide range of histopathologic variants of cutaneous squamous cell carcinoma exists, several of which are associated with aggressive behavior. A review of cutaneous squamous cell carcinoma variants, emphasizing diagnostic pitfalls, immuhistochemical findings and prognostic significance, is included. Of note, the eighth edition of the American Joint Committee on Cancer Staging Manual refers to squamous cell carcinoma of the head and neck only.

  14. Precise genome editing by homologous recombination.

    Science.gov (United States)

    Hoshijima, K; Jurynec, M J; Grunwald, D J

    2016-01-01

    Simple and efficient methods are presented for creating precise modifications of the zebrafish genome. Edited alleles are generated by homologous recombination between the host genome and double-stranded DNA (dsDNA) donor molecules, stimulated by the induction of double-strand breaks at targeted loci in the host genome. Because several kilobase-long tracts of sequence can be exchanged, multiple genome modifications can be generated simultaneously at a single locus. Methods are described for creating: (1) alleles with simple sequence changes or in-frame additions, (2) knockin/knockout alleles that express a reporter protein from an endogenous locus, and (3) conditional alleles in which exons are flanked by recombinogenic loxP sites. Significantly, our approach to genome editing allows the incorporation of a linked reporter gene into the donor sequences so that successfully edited alleles can be identified by virtue of expression of the reporter. Factors affecting the efficiency of genome editing are discussed, including the finding that dsDNA products of I-SceI meganuclease enzyme digestion are particularly effective as donor molecules for gene-editing events. Reagents and procedures are described for accomplishing efficient genome editing in the zebrafish.

  15. Clinical and Pathological Staging Validation in the Eighth Edition of the TNM Classification for Lung Cancer: Correlation between Solid Size on Thin-Section Computed Tomography and Invasive Size in Pathological Findings in the New T Classification.

    Science.gov (United States)

    Aokage, Keiju; Miyoshi, Tomohiro; Ishii, Genichiro; Kusumoto, Masahiro; Nomura, Shogo; Katsumata, Shinya; Sekihara, Keigo; Hishida, Tomoyuki; Tsuboi, Masahiro

    2017-09-01

    The aim of this study was to validate the new eighth edition of the TNM classification and to elucidate whether radiological solid size corresponds to pathological invasive size incorporated in this T factor. We analyzed the data on 1792 patients who underwent complete resection from 2003 to 2011 at the National Cancer Center Hospital East, Japan. We reevaluated preoperative thin-section computed tomography (TSCT) to determine solid size and pathological invasive size using the fourth edition of the WHO classification and reclassified them according to the new TNM classification. The discriminative power of survival curves by the seventh edition was compared with that by the eighth edition by using concordance probability estimates and Akaike's information criteria calculated using a univariable Cox regression model. Pearson's correlation coefficient was calculated to elucidate the correlation between radiological solid size using TSCT and pathological invasive size. The overall survival curves in the eighth edition were well distinct at each clinical and pathological stage. The 5-year survival rates of patients with clinical and pathological stage 0 newly defined were both 100%. The concordance probability estimate and Akaike's information criterion values of the eighth edition were higher than those of the seventh edition in discriminatory power for overall survival. Solid size on TSCT scan and pathological invasive size showed a positive linear relationship, and Pearson's correlation coefficient was calculated as 0.83, which indicated strong correlation. This TNM classification will be feasible regarding patient survival, and radiological solid size correlates significantly with pathological invasive size as a new T factor. Copyright © 2017 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

  16. Fourth-generation storage rings

    Energy Technology Data Exchange (ETDEWEB)

    Galayda, J. N.

    1999-11-16

    It seems clear that a linac-driven free-electron laser is the accepted prototype of a fourth-generation facility. This raises two questions: can a storage ring-based light source join the fourth generation? Has the storage ring evolved to its highest level of performance as a synchrotrons light source? The answer to the second question is clearly no. The author thinks the answer to the first question is unimportant. While the concept of generations has been useful in motivating thought and effort towards new light source concepts, the variety of light sources and their performance characteristics can no longer be usefully summed up by assignment of a ''generation'' number.

  17. The fourth generation in supergravity

    Science.gov (United States)

    Enqvist, K.; Nanopoulos, D. V.; Zwirner, F.

    1985-12-01

    We consider model-independent constraints on the fourth-generation fermion masses and the magnitude of the D-term contribution to the scalar masses. We find that the ratio of vacuum expectation values is limited to the range 1/5 ~ 150 GeV. A general feature of the four-generation models is thus a heavy spectrum of sparticles. On leave from International School for Advanced Studies, Trieste, and Istituto Nazionale di Fisica Nucleare, Padua, Italy.

  18. The Fourth Way in Finland

    Directory of Open Access Journals (Sweden)

    Vesa Iitti

    2008-01-01

    Full Text Available This article focuses on the general history of the Fourth Way in Finland. The Fourth Way, or simply ‘the Work’, began as a Greco-Armenian man named Georges Ivanovich Gurdjieff (1866?–1949 gathered groups of pupils in St Petersburg and Moscow in 1912. To these groups, Gurdjieff started to teach what he had learned and synthesized between ca 1896 and 1912 during his travels on spiritual search of Egypt, Crete, Sumeria, Assyria, the Holy Land, Mecca, Ethiopia, Sudan, India, Afghanistan, the northern valleys of Siberia, and Tibet. Neither Gurdjieff nor any of his disciples called themselves a church, a sect, or anything alike, but referred to themselves simply as ‘the Work’, or as ‘the Fourth Way’. The name ‘the Fourth Way’ originates in a Gurdjieffian view that there are essentially three traditional ways of spiritual work: those of a monk, a fakir, and a yogi. These ways do not literally refer to the activities of a monk, a fakir, and a yogi, but to similar types of spiritual work emphasizing exercise of emotion, body, or mind. Gurdjieff’s teaching is a blend of various influences that include Suf­ism, orthodox Christianity, Buddhism, Kabbalah, and general elem­ents of various occult teachings of both the East and the West. Gurdjieff’s teaching is a blend of various influences that include Suf­ism, orthodox Christianity, Buddhism, Kabbalah, and general elem­ents of various occult teachings of both the East and the West. It is a unique combination of cosmology, psychology, theory of evolution, and overall theory and practise aiming to help individ­uals in their efforts towards what is called ‘self-remembering’.

  19. Developing new levels of edit

    Energy Technology Data Exchange (ETDEWEB)

    Prono, J.K.

    1997-06-01

    Since 1985, Los Alamos National Laboratory (LANL) staff have had four levels of edit to choose from for technical reports. When a CQI survey showed that both authors and editors felt the levels were not meeting author needs, LANL set about revising them. The goals were to simplify the editing process, focus editing on improving technical clarity, and ensure value added in editing. This paper describes the revision process and product--three author-based levels of edit.

  20. CRISPR Genome Editing

    Science.gov (United States)

    A research article about a technique for gene editing known as CRISPR-Cas9. The technique has made it much easier and faster for cancer researchers to study mutations and test new therapeutic targets.

  1. Decimal Classification Editions

    Directory of Open Access Journals (Sweden)

    Zenovia Niculescu

    2009-01-01

    Full Text Available The study approaches the evolution of Dewey Decimal Classification editions from the perspective of updating the terminology, reallocating and expanding the main and auxilary structure of Dewey indexing language. The comparative analysis of DDC editions emphasizes the efficiency of Dewey scheme from the point of view of improving the informational offer, through basic index terms, revised and developed, as well as valuing the auxilary notations.

  2. The fourth dimension simply explained

    CERN Document Server

    Manning, Henry P

    2005-01-01

    To remove the contents of an egg without puncturing its shell or to drink the liquor in a bottle without removing the cork is clearly unthinkable - or is it? Understanding the world of Einstein and curved space requires a logical conception of the fourth dimension.This readable, informative volume provides an excellent introduction to that world, with 22 essays that employ a minimum of mathematics. Originally written for a contest sponsored by Scientific American, these essays are so well reasoned and lucidly written that they were judged to merit publication in book form. Their easily unders

  3. Fourth order deformed general relativity

    CERN Document Server

    Cuttell, Peter D

    2014-01-01

    Whenever the condition of anomaly freedom is imposed within the framework of effective approaches to loop quantum cosmology, one seems to conclude that a deformation of general covariance is required. Here, starting from a general deformation we regain an effective gravitational Lagrangian including terms up to fourth order in extrinsic curvature. We subsequently constrain the form of the corrections, and then investigate the conditions for the occurrence of a big bounce and the realisation of an inflationary era, in the presence of a perfect fluid or scalar field.

  4. Adaptation of A-to-I RNA editing in Drosophila.

    Directory of Open Access Journals (Sweden)

    Yuange Duan

    2017-03-01

    Full Text Available Adenosine-to-inosine (A-to-I editing is hypothesized to facilitate adaptive evolution by expanding proteomic diversity through an epigenetic approach. However, it is challenging to provide evidences to support this hypothesis at the whole editome level. In this study, we systematically characterized 2,114 A-to-I RNA editing sites in female and male brains of D. melanogaster, and nearly half of these sites had events evolutionarily conserved across Drosophila species. We detected strong signatures of positive selection on the nonsynonymous editing sites in Drosophila brains, and the beneficial editing sites were significantly enriched in genes related to chemical and electrical neurotransmission. The signal of adaptation was even more pronounced for the editing sites located in X chromosome or for those commonly observed across Drosophila species. We identified a set of gene candidates (termed "PSEB" genes that had nonsynonymous editing events favored by natural selection. We presented evidence that editing preferentially increased mutation sequence space of evolutionarily conserved genes, which supported the adaptive evolution hypothesis of editing. We found prevalent nonsynonymous editing sites that were favored by natural selection in female and male adults from five strains of D. melanogaster. We showed that temperature played a more important role than gender effect in shaping the editing levels, although the effect of temperature is relatively weaker compared to that of species effect. We also explored the relevant factors that shape the selective patterns of the global editomes. Altogether we demonstrated that abundant nonsynonymous editing sites in Drosophila brains were adaptive and maintained by natural selection during evolution. Our results shed new light on the evolutionary principles and functional consequences of RNA editing.

  5. Common and unique factors associated with DSM-IV-TR internalizing disorders in children.

    Science.gov (United States)

    Higa-McMillan, Charmaine K; Smith, Rita L; Chorpita, Bruce F; Hayashi, Kentaro

    2008-11-01

    With the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association. Diagnostic and statistical manual of mental disorders DSM-IV Fourth Edition-Text Revision. Author, Washington, DC. 2000) ahead, decisions will be made about the future of taxonomic conceptualizations. This study examined the factor structure of items from three internalizing disorders (Social Phobia, Generalized Anxiety Disorder, and Depression) on the Anxiety Disorders Interview Schedule for DSM-IV-Child Version (Silverman, W. K., & Albano, A. M. Anxiety disorders interview schedule for children for DSM-IV, child and parent versions. Psychological Corporation, San Antonio, 1996). Two-, three-, and four-factor models emerged in an exploratory factor analysis. Confirmatory factor analysis provided additional empirical support for the four-factor model over the two- or three-factor models. Implications for the structure of the DSM-V taxonomy in children and adolescents are discussed.

  6. Fourth International Conference on Complex Systems Design & Management

    CERN Document Server

    Boulanger, Frédéric; Krob, Daniel; Marchal, Clotilde

    2014-01-01

    This book contains all refereed papers that were accepted to the fourth edition of the « Complex Systems Design & Management » (CSD&M 2013) international conference which took place in Paris (France) from December 4-6, 2013. These proceedings cover the most recent trends in the emerging field of complex systems sciences & practices from an industrial and academic perspective, including the main industrial domains (transport, defense & security, electronics, energy & environment, e-services), scientific & technical topics (systems fundamentals, systems architecture & engineering, systems metrics & quality, systemic tools) and system types (transportation systems, embedded systems, software & information systems, systems of systems, artificial ecosystems). The CSD&M 2013 conference is organized under the guidance of the CESAMES non-profit organization

  7. Minutes of the fourth SALE program participants meeting

    Energy Technology Data Exchange (ETDEWEB)

    1981-10-01

    This report is a documentation of the presentations made to the Fourth Safeguards Analytical Laboratory Evaluation (S.A.L.E.) Program Participants Meeting at Argonne, Illinois, July 8-9, 1981. The meeting was sponsored by the US Department of Energy and was coordinated by the S.A.L.E. Program of the New Brunswick Laboratory. The objective of the meeting was to provide a forum through which administration of the Program and methods appropriate to the analysis of S.A.L.E. Program samples could be discussed. The Minutes of the Meeting is a collection of presentations by the speakers at the meeting and of the discussions following the presentations. The presentations are included as submitted by the speakers. The discussion sections were transcribed from tape recordings of the meeting and were edited to clarify and emphasize important comments. Seventeen papers have been abstracted and indexed.

  8. Editing Audio with Audacity

    Directory of Open Access Journals (Sweden)

    Brandon Walsh

    2016-08-01

    Full Text Available For those interested in audio, basic sound editing skills go a long way. Being able to handle and manipulate the materials can help you take control of your object of study: you can zoom in and extract particular moments to analyze, process the audio, and upload the materials to a server to compliment a blog post on the topic. On a more practical level, these skills could also allow you to record and package recordings of yourself or others for distribution. That guest lecture taking place in your department? Record it and edit it yourself! Doing so is a lightweight way to distribute resources among various institutions, and it also helps make the materials more accessible for readers and listeners with a wide variety of learning needs. In this lesson you will learn how to use Audacity to load, record, edit, mix, and export audio files. Sound editing platforms are often expensive and offer extensive capabilities that can be overwhelming to the first-time user, but Audacity is a free and open source alternative that offers powerful capabilities for sound editing with a low barrier for entry. For this lesson we will work with two audio files: a recording of Bach’s Goldberg Variations available from MusOpen and another recording of your own voice that will be made in the course of the lesson. This tutorial uses Audacity 2.1.2, released January 2016.

  9. The NMC Horizon Report: 2014 Library Edition

    NARCIS (Netherlands)

    Johnson, L; Adams Becker, S.; Estrada, V.; Freeman, A.; van den Brekel, Guus

    2014-01-01

    The NMC Horizon Report: 2014 Library Edition, examines key trends, significant challenges, and emerging technologies for their potential impact on academic and research libraries worldwide. While there are many local factors affecting libraries, there are also issues that transcend regional boundari

  10. Transportation Energy Data Book, Edition 19

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    1999-09-01

    The Transportation Energy Data Book: Edition 19 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (http://www-cta.ornl.gov/data/tedb.htm).

  11. Dietary Behaviors among Fourth Graders: A Social Cognitive Theory Approach.

    Science.gov (United States)

    Corwin, Sara J.; Sargent, Roger G.; Rheaume, Carol E.; Saunders, Ruth P.

    1999-01-01

    Examined the impact of behavioral, personal, and environmental factors on fourth graders' dietary practices, using a social cognitive theory framework. Survey results highlighted social cognitive variables that significantly influenced dietary behaviors: gender, race, socioeconomic status, fruit and vegetable availability at home, nutrition…

  12. Precision genome editing

    DEFF Research Database (Denmark)

    Steentoft, Catharina; Bennett, Eric P; Schjoldager, Katrine Ter-Borch Gram

    2014-01-01

    of glycobiology, primarily due to their low efficiencies, with resultant failure to impose substantial phenotypic consequences upon the final glycosylation products. Here, we review novel nuclease-based precision genome editing techniques enabling efficient and stable gene editing, including gene disruption...... by introducing single or double-stranded breaks at a defined genomic sequence. We here compare and contrast the different techniques and summarize their current applications, highlighting cases from the field of glycobiology as well as pointing to future opportunities. The emerging potential of precision gene...

  13. The genome editing revolution

    DEFF Research Database (Denmark)

    Stella, Stefano; Montoya, Guillermo

    2016-01-01

    In the last 10 years, we have witnessed a blooming of targeted genome editing systems and applications. The area was revolutionized by the discovery and characterization of the transcription activator-like effector proteins, which are easier to engineer to target new DNA sequences than the previo......In the last 10 years, we have witnessed a blooming of targeted genome editing systems and applications. The area was revolutionized by the discovery and characterization of the transcription activator-like effector proteins, which are easier to engineer to target new DNA sequences than...

  14. Students' perspectives on the fourth year of medical school: a mixed-methods analysis.

    Science.gov (United States)

    Wolf, Stephen J; Lockspeiser, Tai M; Gong, Jennifer; Guiton, Gretchen

    2014-04-01

    Little is known about the purpose and value of the fourth year of medical school from the perspective of medical students. In this study, the authors systematically explored the year's purpose and value as determined by students. In April 2011, the authors conducted semistructured focus groups with graduating fourth-year students at the University of Colorado School of Medicine to understand their perspectives on the purpose of the fourth year. Using results of a thematic analysis of the focus group data, the authors developed and administered a 10-item questionnaire to all graduating fourth-year medical students in May 2011. Questionnaire data were analyzed using descriptive statistics and exploratory factor analysis. A total of 17 students participated in two focus groups. Six themes related to the purpose of the fourth year emerged from the focus group data: career development and preparation, pursuing personal interests, career identification, exploration of diverse practice settings, influence of emotion, and flexibility and individualization. The questionnaire was completed by 134 of 148 students (91% response rate). Factor analysis of the questionnaire data identified five factors: strengthening one's residency application, developing skills, pursuing personal interests, exploring diverse practice settings, and identifying a career. Medical students uniformly identified the fourth year of medical school as having purpose and value, but their views on the fourth year's purpose differed. This finding underscores the importance of the individualization of the fourth year. Students' perspectives should inform any decisions made about modifying fourth-year curricula and structure.

  15. Editing tools. Transcribing and encoding

    NARCIS (Netherlands)

    Spadini, E.

    2015-01-01

    This paper deals with editing tools and editing platforms, i.e. programs used by editors in order to fulfil one or more tasks in the creation of a scholarly digital edition (SDE). Recurring themes in the field of SDEs are the standardization of XML-TEI markup and the success of documentary digital

  16. Reference Encyclopedia of the American Indian. Volume 1, 4th Edition.

    Science.gov (United States)

    Klein, Barry T., Ed.

    Volume 1 of the fourth edition of the encyclopedia contains directory and descriptive listings of organizations in the United States and Canada, resource materials concerning North American Indians, and a bibliography of in-print books about the American Indian. The first section of the volume contains source listings of government agencies,…

  17. The cytidine deaminase signature HxE(x)n CxxC of DYW1 binds zinc and is necessary for RNA editing of ndhD-1

    DEFF Research Database (Denmark)

    Boussardon, Clément; Avon, Alexandra; Kindgren, Peter

    2014-01-01

    In flowering plants, RNA editing involves deamination of specific cytidines to uridines in both mitochondrial and chloroplast transcripts. Pentatricopeptide repeat (PPR) proteins and multiple organellar RNA editing factor (MORF) proteins have been shown to be involved in RNA editing but none have...... that this domain forms part of the active enzyme that carries out RNA editing in plants....

  18. Beginning to edit physics

    Energy Technology Data Exchange (ETDEWEB)

    Murphy, P.W.

    1995-02-01

    A physicist-turned-editor shows you the basics required for copyediting physics papers (physical quantities, symbols, units, scientific notation, the structure of mathematical expressions, the nature of graphs), and points the way to learning enough ``editorial physics`` to begin substantive editing.

  19. Generation of gene edited birds in one generation using sperm transfection assisted gene editing (STAGE).

    Science.gov (United States)

    Cooper, Caitlin A; Challagulla, Arjun; Jenkins, Kristie A; Wise, Terry G; O'Neil, Terri E; Morris, Kirsten R; Tizard, Mark L; Doran, Timothy J

    2016-11-28

    Generating transgenic and gene edited mammals involves in vitro manipulation of oocytes or single cell embryos. Due to the comparative inaccessibility of avian oocytes and single cell embryos, novel protocols have been developed to produce transgenic and gene edited birds. While these protocols are relatively efficient, they involve two generation intervals before reaching complete somatic and germline expressing transgenic or gene edited birds. Most of this work has been done with chickens, and many protocols require in vitro culturing of primordial germ cells (PGCs). However, for many other bird species no methodology for long term culture of PGCs exists. Developing methodologies to produce germline transgenic or gene edited birds in the first generation would save significant amounts of time and resource. Furthermore, developing protocols that can be readily adapted to a wide variety of avian species would open up new research opportunities. Here we report a method using sperm as a delivery mechanism for gene editing vectors which we call sperm transfection assisted gene editing (STAGE). We have successfully used this method to generate GFP knockout embryos and chickens, as well as generate embryos with mutations in the doublesex and mab-3 related transcription factor 1 (DMRT1) gene using the CRISPR/Cas9 system. The efficiency of the method varies from as low as 0% to as high as 26% with multiple factors such as CRISPR guide efficiency and mRNA stability likely impacting the outcome. This straightforward methodology could simplify gene editing in many bird species including those for which no methodology currently exists.

  20. Confirmatory factor analysis of the WAIS-IV/WMS-IV.

    Science.gov (United States)

    Holdnack, James A; Xiaobin Zhou; Larrabee, Glenn J; Millis, Scott R; Salthouse, Timothy A

    2011-06-01

    The Wechsler Adult Intelligence Scale-fourth edition (WAIS-IV) and the Wechsler Memory Scale-fourth edition (WMS-IV) were co-developed to be used individually or as a combined battery of tests. The independent factor structure of each of the tests has been identified; however, the combined factor structure has yet to be determined. Confirmatory factor analysis was applied to the WAIS-IV/WMS-IV Adult battery (i.e., age 16-69 years) co-norming sample (n = 900) to test 13 measurement models. The results indicated that two models fit the data equally well. One model is a seven-factor solution without a hierarchical general ability factor: Verbal Comprehension, Perceptual Reasoning, Processing Speed, Auditory Working Memory, Visual Working Memory, Auditory Memory, and Visual Memory. The second model is a five-factor model composed of Verbal Comprehension, Perceptual Reasoning, Processing Speed, Working Memory, and Memory with a hierarchical general ability factor. Interpretative implications for each model are discussed.

  1. Fourth Lepton Family is Natural in Technicolor

    DEFF Research Database (Denmark)

    T. Frandsen, Mads; Masina, Isabella; Sannino, Francesco

    2010-01-01

    structure with and without mixing with the Standard Model families. We also analyze the LHC potential to observe the fourth lepton family in tandem with the new composite Higgs dynamics. We finally introduce a model uniting the fourth lepton family and the technifermion sector at higher energies.......Imagine to discover a new fourth family of leptons at the Large Hadron Collider (LHC) but no signs of an associated fourth family of quarks. What would that imply? An intriguing possibility is that the new fermions needed to compensate for the new leptons gauge anomalies simultaneously address...

  2. Technology Integration in Third, Fourth and Fifth Grade Classrooms in a Florida School District

    Science.gov (United States)

    Pittman, Tiffani; Gaines, Trudi

    2015-01-01

    Third, fourth and fifth grade teachers have the potential to shape the way their students will begin to view and use technology. This study investigated the nature of technology usage among third, fourth and fifth grade teachers in a Florida school district as well as the relationship between the level of technology usage factors such as available…

  3. Technology Integration in Third, Fourth and Fifth Grade Classrooms in a Florida School District

    Science.gov (United States)

    Pittman, Tiffani; Gaines, Trudi

    2015-01-01

    Third, fourth and fifth grade teachers have the potential to shape the way their students will begin to view and use technology. This study investigated the nature of technology usage among third, fourth and fifth grade teachers in a Florida school district as well as the relationship between the level of technology usage factors such as available…

  4. Fan edits and the legacy of The Phantom Edit

    Directory of Open Access Journals (Sweden)

    Joshua Wille

    2014-09-01

    Full Text Available A fan edit can generally be defined as an alternative version of a film or television text created by a fan. It offers a different viewing experience, much as a song remix offers a different listening experience. The contemporary wave of fan edits has emerged during the remix zeitgeist of digital media and at a time when digital video editing technology has become more affordable and popular. The increasing number of alternative versions of films and the works of revisionist Hollywood filmmakers such as George Lucas have contributed to a greater public understanding of cinema as a fluid medium instead of one that exists in a fixed form. The Phantom Edit (2000, a seminal fan edit based on Lucas's Star Wars Episode I: The Phantom Menace (1999, inspired new ranks of fan editors. However, critics have misunderstood fan edits as merely the work of disgruntled fans. In order to provide a critical and historical basis for studies in fan editing as a creative practice, I examine previous interpretations of fan edits in the context of relevant contemporary works, and I use an annotated chronology of The Phantom Edit to trace its influence on subsequent fan editing communities and uncover their relationship with intellectual property disputes.

  5. Extreme Makeover: Reading Edition

    Science.gov (United States)

    Ray, Rachel

    2011-01-01

    Located in Lancaster, South Carolina, Clinton Elementary School enrolls approximately 400 students in pre-kindergarten through grade 5. Ninety-five percent of students are minority and 5 percent are white. Currently, 99 percent of students receive free or reduced-price lunch. In addition to the school having a high poverty rate, one-fourth of the…

  6. Cognitive Proficiency Index for the Canadian Edition of the Wechsler Intelligence Scale for Children-Fourth Edition

    Science.gov (United States)

    Saklofske, Donald H.; Zhu, Jianjun; Coalson, Diane L.; Raiford, Susan E.; Weiss, Lawrence G.

    2010-01-01

    The Cognitive Proficiency Index (CPI) developed for the most recent Wechsler intelligence scales comprises the working memory and processing speed subtests. It reflects the proficiency and efficiency of cognitive processing and provides another lens for analyzing children's abilities assessed by the Wechsler Intelligence Scale for Children--Fourth…

  7. United States housing, fourth quarter 2013

    Science.gov (United States)

    Delton Alderman

    2017-01-01

    In the beginning of 2013, the U.S. housing construction market indicated increases in all sectors; yet, by the fourth quarter’s end, only housing under construction improved. Moderation and declines are to be expected in the fourth quarter, as winter is setting in. Permits, starts, housing under construction, completions, and new and existing house sales all exceeded...

  8. Osteoblastic meningioma of the fourth ventricle.

    Science.gov (United States)

    Johnson, M D; Tulipan, N; Whetsell, W O

    1989-04-01

    Meningiomas of the fourth ventricle are rare neoplasms. Only meningothelial and fibroblastic subtypes, purportedly arising from the tela choroidea, have been described. In this report we describe clinical, neuroradiological and pathological findings in a 52-year-old man with mild hydrocephalus produced by a large, calcified, osteoblastic meningioma of the fourth ventricle.

  9. The Craft of Editing

    DEFF Research Database (Denmark)

    Moeran, Brian

    To edit is to make a choice, or series of choices. Will I write a rough draft of this essay in longhand, or hammer it out on my computer? If the latter, what font shall I use? Times New Roman, Book Antiqua, or Garamond? Once I get started, what style shall I adopt: realistic, confessional or impr...... or impressionistic; or a combination of all three (Van Maanen 1988)? Should I try to impress with ‘learned scholarship’, or should I merely outline in conversational English a few thoughts based on my own experiences?......To edit is to make a choice, or series of choices. Will I write a rough draft of this essay in longhand, or hammer it out on my computer? If the latter, what font shall I use? Times New Roman, Book Antiqua, or Garamond? Once I get started, what style shall I adopt: realistic, confessional...

  10. Video Editing System

    Science.gov (United States)

    Schlecht, Leslie E.; Kutler, Paul (Technical Monitor)

    1998-01-01

    This is a proposal for a general use system based, on the SGI IRIS workstation platform, for recording computer animation to videotape. In addition, this system would provide features for simple editing and enhancement. Described here are a list of requirements for the system, and a proposed configuration including the SGI VideoLab Integrator, VideoMedia VLAN animation controller and the Pioneer rewritable laserdisc recorder.

  11. Understanding Physics, First Edition

    Science.gov (United States)

    Cummings, Karen; Laws, Priscilla W.; Redish, Edward F.; Cooney, Patrick J.

    2004-03-01

    Built on the foundations of Halliday, Resnick, and Walker's Fundamentals of Physics Sixth Edition, this text is designed to work with interactive learning strategies that are increasingly being used in physics instruction (for example, microcomputer-based labs, interactive lectures, etc. ). In doing so, it incorporates new approaches based upon Physics Education Research (PER), aligns with courses that use computer-based laboratory tools, and promotes Activity Based Physics in lectures, labs, and recitations.

  12. Investigating the Hierarchical Factor Structure of the Fifth Edition of the 16PF: An Application of the Schmid-Leiman Orthogonalization Procedure.

    Science.gov (United States)

    Chernyshenko, Oleksandr S.; Stark, Stephen; Chan, Kim Yin

    2001-01-01

    Studied the unidimensionality of the 16 noncognitive scales of the Sixteen Personality Factor Questionnaire (16PF) and the hierarchical factor structure of the inventory. Results using the Schmid Leiman orthogonalization procedure (J. Schmid and J. Leiman, 1957) showed that the noncognitive multi-item composites could be factored into 16…

  13. Revising and editing for translators

    CERN Document Server

    Mossop, Brian

    2014-01-01

    Revising and Editing for Translators provides guidance and learning materials for translation students learning to edit texts written by others, and professional translators wishing to improve their self-revision ability or learning to revise the work of others. Editing is understood as making corrections and improvements to texts, with particular attention to tailoring them to the given readership. Revising is this same task applied to draft translations. The linguistic work of editors and revisers is related to the professional situations in which they work. Mossop offers in-depth coverage of a wide range of topics, including copyediting, style editing, structural editing, checking for consistency, revising procedures and principles, and translation quality assessment. This third edition provides extended coverage of computer aids for revisers, and of the different degrees of revision suited to different texts. The inclusion of suggested activities and exercises, numerous real-world examples, a proposed gra...

  14. Electrochemical Dictionary-Second Edition

    OpenAIRE

    Gulaboski, Rubin

    2012-01-01

    The 1st edition of the “Electrochemical Dictionary” has received a very positive, even enthusiastic, resonance. It is one of themost successful e-books of Springer. The second edition of the “Electrochemical Dictionary” provides a considerably extended coverage of terms, especially in the fields of electrochemical energy conversion and bioelectricity. Some new authors joined the project, so that their number is now 100. All entries of the first edition were carefully revised, and ref...

  15. [One hundred years of Freud editions in The Netherlands].

    Science.gov (United States)

    Greven, Elsbeth

    2009-01-01

    The history of Dutch editions of Freud is discussed from a publisher's point of view. The author focuses on the main publishers involved in presenting Freud's work to the Dutch public: S. C. van Doesburgh, De Wereldbibliotheek, De Bezige Bij and Uitgeverij Boom. She describes their role, together with their networks of translators, editors and psychoanalysts, in the production, perception and reception of Freud's work--and hence in the development of psychoanalysis in The Netherlands--as well as their approaches to translation, publishing strategies and use of paratextual resources. Three main stages can be identified: 1. 1912 to World War I (Freud was introduced), 2. World War I to 1950 (Freud was popularised), and 3. 1960 to 1990 (Freud was canonised, but also criticised). A fourth stage, the historicisation of Freud, began in 2006 with a new, scholarly edition of his Werken, arranged in chronological order.

  16. REDIdb: the RNA editing database.

    Science.gov (United States)

    Picardi, Ernesto; Regina, Teresa Maria Rosaria; Brennicke, Axel; Quagliariello, Carla

    2007-01-01

    The RNA Editing Database (REDIdb) is an interactive, web-based database created and designed with the aim to allocate RNA editing events such as substitutions, insertions and deletions occurring in a wide range of organisms. The database contains both fully and partially sequenced DNA molecules for which editing information is available either by experimental inspection (in vitro) or by computational detection (in silico). Each record of REDIdb is organized in a specific flat-file containing a description of the main characteristics of the entry, a feature table with the editing events and related details and a sequence zone with both the genomic sequence and the corresponding edited transcript. REDIdb is a relational database in which the browsing and identification of editing sites has been simplified by means of two facilities to either graphically display genomic or cDNA sequences or to show the corresponding alignment. In both cases, all editing sites are highlighted in colour and their relative positions are detailed by mousing over. New editing positions can be directly submitted to REDIdb after a user-specific registration to obtain authorized secure access. This first version of REDIdb database stores 9964 editing events and can be freely queried at http://biologia.unical.it/py_script/search.html.

  17. Depletion of elongation initiation factor 4E binding proteins by CRISPR/Cas9 genome editing enhances antiviral response in porcine cells

    Science.gov (United States)

    Type I interferons (IFN) are key mediators of the innate antiviral response in mammalian cells. Elongation initiation factor 4E binding proteins (4E-BPs) are translational controllers of interferon regulatory factor 7 (IRF7), the master regulator of IFN transcription. The role of 4EBPs in the negat...

  18. Proceedings of the fourth National Congress of the Italian Society of Virology.

    Science.gov (United States)

    Salata, Cristiano; Parolin, Cristina; Palù, Giorgio

    2005-09-01

    The aim of the yearly National Congress of the Italian Society of Virology (SIV) is to promote the discussion between senior and younger researchers to improve the knowledge and scientific collaboration among the various areas of Virology. The invited and selected lecturers of the fourth National Congress of SIV covered the following topics: general Virology and viral Genetics; virus host interactions and pathogenesis; viral immunology and vaccines; emerging and re-emerging viral diseases; antiviral therapy; innovative diagnostics; viral biotechnologies and gene therapy. As in the previous edition (Salata and Palù, 2004 J Cell Physiol 199:171-173), a specific topic was thoroughly covered in a roundtable. In this edition the overviewed topic was HCV, from epidemiology and genetic variability to immunology and antiviral therapy. The final program can be found at the web site http://www.siv-virologia.it. A summary of the oral presentations of the 2004 meeting is reported.

  19. The Fourth Wave in Deterrence Research

    OpenAIRE

    Knopf, Jeffrey W.

    2010-01-01

    The article of record as published may be located at http://dx.doi.org/10.1080/13523261003640819 A new line of work on deterrence began emerging after the end of the Cold War and gained momentum after the September 11 terrorist attacks. Building on a previous characterization by Robert Jervis that identified three waves of deterrence research,1 this work is here designated the fourth wave. The fourth wave reflects a change from a focus on relatively symmetrical situations of mu...

  20. Annotation in Digital Scholarly Editions

    NARCIS (Netherlands)

    Boot, P.; Haentjens Dekker, R.

    2016-01-01

    Annotation in digital scholarly editions (of historical documents, literary works, letters, etc.) has long been recognized as an important desideratum, but has also proven to be an elusive ideal. In so far as annotation functionality is available, it is usually developed for a single edition and

  1. Transportation Energy Data Book, Edition 18

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy C.

    1998-09-01

    The Transportation Energy Data Book: Edition 18 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. This edition of the Data Book has 11 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 - energy Chapter 3 - emissions; Chapter 4 - transportation and the economy; Chapter 5 - highway vehicles; Chapter 6 - Light vehicles; Chapter 7 - heavy vehicles; Chapter 8 - alternative fuel vehicles; Chapter 9 - fleet vehicles; Chapter 10 - household vehicles; and Chapter 11 - nonhighway modes. The sources used represent the latest available data.

  2. A Unifying Field in Logics: Neutrosophic Logic, Neutrosophic Set, Neutrosophic Probability and Statistics (fourth edition)

    OpenAIRE

    2001-01-01

    In this book one makes an introduction to non-standard analysis in the first part, needed to the next four chapters in order to study the neutrosophics: 1. Neutrosophy - a new branch of philosophy. 2. Neutrosophic Logic - a unifying field in logics. 3. Neutrosophic Set - a unifying field in sets. 4. Neutrosophic Probability - a generalization of classical and imprecise probabilities - and Neutrosophic Statistics.

  3. 76 FR 23823 - Guidance for Industry on Fish and Fishery Products Hazards and Controls, Fourth Edition...

    Science.gov (United States)

    2011-04-28

    ... principles of HACCP. Fish and fishery products are adulterated under section 402(a)(4) of the Federal Food... chapter has been added containing guidance for the control of pathogen survival through processes designed... HUMAN SERVICES Food and Drug Administration Guidance for Industry on Fish and Fishery Products...

  4. Problem Solving: Tools and Techniques for the Park and Recreation Administrator. Fourth Edition

    Science.gov (United States)

    Arnold, Margaret L.; Heyne, Linda A.; Busser, James A.

    2005-01-01

    This book is a useful tool for recreation educators in carrying out their responsibilities for preparing the next generation for effective service in recreation and parks. The need for this book is apparent, because few recreation curricula include courses in problem solving. It is true that many texts dealing with recreation describe policies and…

  5. Measuring Price Changes: A Study of the Price Indexes. Fourth Edition.

    Science.gov (United States)

    Wallace, William H.; Cullison, William E.

    This three-part monograph examines the major price indexes used to measure the intensity of inflation. The first part discusses the recent behavior of prices as measured by the Consumer Price Index (commodities, goods, and services), the Producer Price Index (wholesale prices of crude materials, intermediate materials, supplies, components, and…

  6. United States Air Force Statistical Digest, Fiscal Year 1979, Thirty-Fourth Edition

    Science.gov (United States)

    1980-06-30

    Force Simpson Historical Research Center Air Force Service Information and News Center Air Force Intelligence Service. Air Force Inspection and Saftey ...Examination (Standard Form 88); physical inspections of food handlers or barbers are not included nor are examina- tions of personnel who are ill

  7. United States Air Force Statistical Digest, Fiscal Year 1969. Twenty-fourth Edition

    Science.gov (United States)

    1970-02-02

    PROPERTY - Personal propert.y which, through screening or other means, has been determined to bee in excess to all federal agency r-equ.i r ement.s...Investigations, Special 1,486 1,485 1 - 1,488 1,487 1 -77 Ultra-Sensitive Positions 1,025 906 104 15 1,045 930 96 19 144 Premarital Investigations 749 13...2,412 71 12 77 Ultra- Sensitive Positions 219 174 4 41 I 214 170 4 40 144 Premarital Investigations 2 - 1 1\\ 4 2 1 1 149 Name Traces 379 367 2 10 I 360

  8. Stress Education Curriculum: Grades 6-12, Middle and High School Levels. Revised Fourth Edition.

    Science.gov (United States)

    Trotter, Jennie C.

    Everyone experiences stress; there is no escaping it. This manual is concerned with teaching young people various positive coping skills to help them handle stress in their lives. It is designed to help professionals such as teachers, nurses, school counselors, and youth recreational leaders teach students lessons on stress management. It is…

  9. Development and Reliability of the Indonesian Wechsler Adult Intelligence Scale—Fourth Edition (WAIS-IV)

    NARCIS (Netherlands)

    Suwartono, C.; Halim, M.S.; Hidajat, L.L.; Hendriks, M.P.H.; Kessels, R.P.C.

    2014-01-01

    Through the years, several translated versions of Wechsler’s intelligence test have been used in Indonesia, in clinical, educational or industrial settings. However, instruments such as Wechsler-Bellevue Intelligence Scale are outdated, have not been validated and lack proper normative data, resulti

  10. The National Adult Reading Test: restandardisation against the Wechsler Adult Intelligence Scale-Fourth edition.

    Science.gov (United States)

    Bright, Peter; Hale, Emily; Gooch, Vikki Jayne; Myhill, Thomas; van der Linde, Ian

    2016-09-14

    Since publication in 1982, the 50-item National Adult Reading Test (NART; Nelson, 1982 ; NART-R; Nelson & Willison, 1991 ) has remained a widely adopted method for estimating premorbid intelligence both for clinical and research purposes. However, the NART has not been standardised against the most recent revisions of the Wechsler Adult Intelligence Scale (WAIS-III; Wechsler, 1997 , and WAIS-IV; Wechsler, 2008 ). Our objective, therefore, was to produce reliable standardised estimates of WAIS-IV IQ from the NART. Ninety-two neurologically healthy British adults were assessed and regression equations calculated to produce population estimates of WAIS-IV full-scale IQ (FSIQ) and constituent index scores. Results showed strong NART/WAIS-IV FSIQ correlations with more moderate correlations observed between NART error and constituent index scores. FSIQ estimates were closely similar to the published WAIS and WAIS-R estimates at the high end of the distribution, but at the lower end were approximately equidistant from the highly discrepant WAIS (low) and WAIS-R (high) values. We conclude that the NART is likely to remain an important tool for estimating the impact of neurological damage on general cognitive ability. We advise caution in the use of older published WAIS and/or WAIS-R estimates for estimating premorbid WAIS-IV FSIQ, particularly for those with low NART scores.

  11. Development and Reliability of the Indonesian Wechsler Adult Intelligence Scale—Fourth Edition (WAIS-IV)

    OpenAIRE

    Suwartono, C.; Halim, M. S.; Hidajat, L.L.; Hendriks, M.P.H.; Kessels, R.P.C.

    2014-01-01

    Through the years, several translated versions of Wechsler’s intelligence test have been used in Indonesia, in clinical, educational or industrial settings. However, instruments such as Wechsler-Bellevue Intelligence Scale are outdated, have not been validated and lack proper normative data, resulting in measurement errors and invalid decisions made on the intellectual potential of individuals. The primary aim of this study was to adapt and validate the Wechsler Adult Intelligence Scale—fourt...

  12. The National Adult Reading Test: restandardisation against the Wechsler Adult Intelligence Scale—Fourth edition

    OpenAIRE

    Bright, Peter; Hale, Emily; Gooch, Victoria; Myhill, Thomas; Van Der Linde, Ian

    2016-01-01

    Since publication in 1982, the 50-item National Adult Reading Test (NART; Nelson, 1982; NART–R; Nelson & Willison, 1991) has remained a widely adopted method for estimating premorbid intelligence both for clinical and research purposes. However, the NART has not been standardised against the most recent revisions of the Wechsler Adult Intelligence Scale (WAIS-III (1997) and WAIS-IV (2008)). Our objective, therefore, was to produce reliable standardised estimates of WAIS-IV IQ from the NART. N...

  13. Development and Reliability of the Indonesian Wechsler Adult Intelligence Scale—Fourth Edition (WAIS-IV)

    NARCIS (Netherlands)

    Suwartono, C.; Halim, M.S.; Hidajat, L.L.; Hendriks, M.P.H.; Kessels, R.P.C.

    2014-01-01

    Through the years, several translated versions of Wechsler’s intelligence test have been used in Indonesia, in clinical, educational or industrial settings. However, instruments such as Wechsler-Bellevue Intelligence Scale are outdated, have not been validated and lack proper normative data, resulti

  14. USAMRIID’s Medical Management of Biological Casualties Handbook, Fourth Edition

    Science.gov (United States)

    2001-02-01

    Ciprofloxacin 500 mg q 12 h x 3 d Quinolones for tetra/doxy resistant strains Norfloxacin 400 mg q 12 h x 3 d Q Fever IND 610 - inactivated whole...unlikely that the battlefield provider, especially at lower echelons, removed from sophisticated laboratory and preventive medicine resources, will...penicillin, ciprofloxacin , or doxycycline should be undertaken. Supportive therapy may be necessary. Prophylaxis: Oral ciprofloxacin or doxycycline

  15. Fundamentals of Welding. Teacher Edition [and] Student Edition [and] Student Workbook. Second Edition.

    Science.gov (United States)

    Fortney, Clarence; Gregory, Mike; New, Larry

    Teacher and student editions and a student workbook for fundamentals of welding comprise the first of six in a series of competency-based instructional materials for welding programs. Introductory pages in the teacher edition are training and competency profile, instructional/task analysis, basic skills icons and classifications, basic skills…

  16. Oxyacetylene Welding and Oxyfuel Cutting. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

    Science.gov (United States)

    Knapp, John; Harper, Eddie

    This Oklahoma curriculum guide, which includes a teacher edition, a student edition, and a student workbook, provides three units for a course on oxyacetylene welding, oxyfuel cutting, and cutting done with alternative fuels such as MAPP, propane, and natural gas. The three units are: "Oxyacetylene Welding"; "Oxyfuel Cutting";…

  17. Introduction to Surgical Technology. Third Edition. Teacher Edition [and] Student Edition.

    Science.gov (United States)

    Bushey, Vicki; Hildebrand, Bob; Hildebrand, Dinah; Johnson, Dave; Sikes, John; Tahah, Ann; Walker, Susan; Zielsdorf, Lani

    These teacher and student editions provide instructional materials for an introduction to surgical technology course. Introductory materials in the teacher edition include information on use, instructional/task analysis, academic and workplace skill classifications and definitions, related academic and workplace skill list, and crosswalk to…

  18. Residential and Light Commercial HVAC. Teacher Edition and Student Edition. Second Edition.

    Science.gov (United States)

    Stephenson, David

    This package contains teacher and student editions of a residential and light commercial heating, ventilation, and air conditioning (HVAC) course of study. The teacher edition contains information on the following: using the publication; national competencies; competency profile; related academic and workplace skills list; tools, equipment, and…

  19. Residential and Light Commercial HVAC. Teacher Edition and Student Edition. Second Edition.

    Science.gov (United States)

    Stephenson, David

    This package contains teacher and student editions of a residential and light commercial heating, ventilation, and air conditioning (HVAC) course of study. The teacher edition contains information on the following: using the publication; national competencies; competency profile; related academic and workplace skills list; tools, equipment, and…

  20. Prediction and Research of Development Control Factor of Fourth Member’s Salt Lake Reservoir%沙四下盐湖储层发育控制因素预测研究

    Institute of Scientific and Technical Information of China (English)

    王译庆; 李亚辉

    2013-01-01

    盐湖盆地的石油资源勘探,长期以来一直是国际石油界所密切关注、饶有兴趣的一个研究领域。深化东营凹陷膏盐岩的成因分析,通过大量的资料查询、岩芯的详细观察和分析化验资料,搞清楚东营凹陷中泥页岩、膏盐岩以及碎屑砂岩的成因。同时通过大量的岩芯观察利用马尔科夫链的方法建立东营凹陷沙四下亚段盐湖相的沉积序列,并预测储层的有利发育位置,可以为含盐盆地油气成藏规律研究提供很好的沉积学基础。%The oil resources exploration of salt lake basin has always been a closely intentioned and widely interested research field by international representatives, interesting a research field. Deepening the cause analyses of Dongying sag cream rock, through a large amount of information inquiry, core detailed observation and analysis of the test material, finding out clearly the causes of the shale, paste rock and clastic sandstone in Dongying sag, and at the same time, using markov chain method to establish the sedimentary sequence of salt lake facies of the latter in Dongying sag fourth menber through a large number of core observation, and predict the advantageous position for reservoir development, thus we can provide a very good sedimentology foundation for salt basin hydrocarbon accumulation law research.

  1. The Naturalness of the Fourth SM Family

    CERN Document Server

    Sultansoy, S

    2009-01-01

    The necessity of the fourth family follows from the SM basics. According to flavor democracy the Dirac masses of the fourth SM family fermions are almost equal with preferable value 450 GeV, which corresponds to common (for all fundamental fermions) Yukawa coupling equal to SU(2) gauge coupling gW. In principle, one expect u4 a little bit lighter than d4, while nu4 could be essentially lighter than l4 due to Majorana mass terms for right-handed components of neutrinos. Obviously, the fourth family quarks will be copiously produced at the LHC. However, the first indication of the fourth SM family may be provided by early Higgs boson observation due to almost an order enhancement of the gluon fusion to Higgs cross-section. For the same reason the Tevatron still has a chance to observe the Higgs boson before the LHC. Concerning the fourth family leptons, in general, best place will be NLC/CLIC. However, for some mass regions and MNS matrix elements double discovery of both the nu4 and H could be possible at the ...

  2. Fast Quasi-Threshold Editing

    CERN Document Server

    Brandes, Ulrik; Strasser, Ben; Wagner, Dorothea

    2015-01-01

    We introduce Quasi-Threshold Mover (QTM), an algorithm to solve the quasi-threshold (also called trivially perfect) graph editing problem with edge insertion and deletion. Given a graph it computes a quasi-threshold graph which is close in terms of edit count. This edit problem is NP-hard. We present an extensive experimental study, in which we show that QTM is the first algorithm that is able to scale to large real-world graphs in practice. As a side result we further present a simple linear-time algorithm for the quasi-threshold recognition problem.

  3. Tools of Radio Astronomy, 5th edition

    Science.gov (United States)

    Wilson, Thomas L.; Rohlfs, Kristian; Huttemeister, Susanne

    2012-12-01

    New 5th corrected edition of the book http://adsabs.harvard.edu/abs/2009tra..book.....W in Russian, translated by O. Verkhodanov and S. Trushkin, editing S.A. Trushkin from Special astrophysical observatory RAS. This edition contains the translation of the 5th Springer edition of 2009 and new additional chapter (wrote by authors) of Solutions of the problems.

  4. Transportation Energy Data Book (Edition 20)

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    2000-10-09

    The ''Transportation Energy Data Book: Edition 20'' is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (www-cta.ornl.gov/data/tedb.htm). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2--energy; Chapter 3--greenhouse gas emissions; Chapter 4--criteria pollutant emissions; Chapter 5--transportation and the economy; Chapter 6--highway vehicles; Chapter 7--light vehicles; Chapter 8--heavy vehicles; Chapter 9--alternative fuel vehicles; Chapter 10--fleet vehicles; Chapter 11--household vehicles; and Chapter 12--nonhighway modes. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  5. Transportation Energy Data Book: Edition 34

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Williams, Susan E [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Boundy, Robert Gary [Roltek, Inc., Clinton, TN (United States)

    2015-08-01

    The Transportation Energy Data Book: Edition 34 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  6. Edit Distance to Monotonicity in Sliding Windows

    CERN Document Server

    Chan, Ho-Leung; Lee, Lap-Kei; Pan, Jiangwei; Ting, Hing-Fung; Zhang, Qin

    2011-01-01

    Given a stream of items each associated with a numerical value, its edit distance to monotonicity is the minimum number of items to remove so that the remaining items are non-decreasing with respect to the numerical value. The space complexity of estimating the edit distance to monotonicity of a data stream is becoming well-understood over the past few years. Motivated by applications on network quality monitoring, we extend the study to estimating the edit distance to monotonicity of a sliding window covering the $w$ most recent items in the stream for any $w \\ge 1$. We give a deterministic algorithm which can return an estimate within a factor of $(4+\\eps)$ using $O(\\frac{1}{\\eps^2} \\log^2(\\eps w))$ space. We also extend the study in two directions. First, we consider a stream where each item is associated with a value from a partial ordered set. We give a randomized $(4+\\epsilon)$-approximate algorithm using $O(\\frac{1}{\\epsilon^2} \\log \\epsilon^2 w \\log w)$ space. Second, we consider an out-of-order strea...

  7. Transportation Energy Data Book: Edition 21

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    2001-09-13

    The ''Transportation Energy Data Book: Edition 21'' is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Transportation Technologies in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (www-cta.ornl.gov/data/tedb.htm). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2--energy; Chapter 3--greenhouse gas emissions; Chapter 4--criteria pollutant emissions; Chapter 5--transportation and the economy; Chapter 6--highway vehicles; Chapter 7--light vehicles; Chapter 8--heavy vehicles; Chapter 9--alternative fuel vehicles; Chapter 10--fleet vehicles; Chapter 11--household vehicles; and Chapter 12--nonhighway modes. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  8. Transportation Energy Data Book: Edition 22

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy C.; Diegel, Susan W.

    2002-12-04

    The Transportation Energy Data Book: Edition 22 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (www.cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 - energy; Chapter 3 - greenhouse gas emissions; Chapter 4 - criteria pollutant emissions; Chapter 5 - transportation and the economy; Chapter 6 - highway vehicles; Chapter 7 - light vehicles; Chapter 8 - heavy vehicles; Chapter 9 - alternative fuel vehicles; Chapter 10 - fleet vehicles; Chapter 11 - household vehicles; and Chapter 12- nonhighway modes. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  9. Transportation Energy Data Book: Edition 23

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    2003-10-24

    The ''Transportation Energy Data Book: Edition 23'' is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (www-cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2--energy; Chapter 3--highway vehicles; Chapter 4--light vehicles; Chapter 5--heavy vehicles; Chapter 6--alternative fuel vehicles; Chapter 7--fleet vehicles; Chapter 8--household vehicles; and Chapter 9--nonhighway modes; Chapter 10--transportation and the economy; Chapter 11--greenhouse gas emissions; and Chapter 12--criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  10. Transportation Energy Data Book: Edition 35

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Williams, Susan E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Boundy, Robert Gary [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-10-01

    The Transportation Energy Data Book: Edition 35 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  11. Transportation Energy Data Book: Edition 24

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    2005-03-08

    The ''Transportation Energy Data Book: Edition 24'' is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2--energy; Chapter 3--highway vehicles; Chapter 4--light vehicles; Chapter 5--heavy vehicles; Chapter 6--alternative fuel vehicles; Chapter 7--fleet vehicles; Chapter 8--household vehicles; and Chapter 9--nonhighway modes; Chapter 10--transportation and the economy; Chapter 11--greenhouse gas emissions; and Chapter 12--criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  12. Transportation Energy Data Book: Edition 25

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL

    2006-06-01

    The Transportation Energy Data Book: Edition 25 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 - energy; Chapter 3 - highway vehicles; Chapter 4 - light vehicles; Chapter 5 - heavy vehicles; Chapter 6 - alternative fuel vehicles; Chapter 7 - fleet vehicles; Chapter 8 - household vehicles; and Chapter 9- nonhighway modes; Chapter 10 - transportation and the economy; Chapter 11 - greenhouse gas emissions; and Chapter 12 - criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  13. Transportation Energy Data Book. Edition 33

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Williams, Susan E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Boundy, Robert Gary [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-07-01

    The Transportation Energy Data Book: Edition 33 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  14. Transportation Energy Data Book: Edition 32

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2013-08-01

    The Transportation Energy Data Book: Edition 32 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Office. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  15. Transportation Energy Data Book: Edition 31

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2012-08-01

    The Transportation Energy Data Book: Edition 31 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  16. Transportation Energy Data Book: Edition 30

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2011-07-01

    The Transportation Energy Data Book: Edition 30 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  17. Transportation Energy Data Book: Edition 29

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2010-07-01

    The Transportation Energy Data Book: Edition 29 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program. Designed for use as a desk-top reference, the Data Book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book is available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the reader s convenience.

  18. Transportation Energy Data Book: Edition 28

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2009-06-01

    The Transportation Energy Data Book: Edition 28 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with U.S Department of Energy, Office of Energy Efficiency and Renewable Energy, Vehicle Technologies Program and the Hydrogen, Fuel Cells, and Infrastructure Technologies Program. Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest edition of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; and Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  19. Transportation Energy Data Book: Edition 27

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL; Boundy, Robert Gary [ORNL

    2008-06-01

    The Transportation Energy Data Book: Edition 27 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 energy; Chapter 3 highway vehicles; Chapter 4 light vehicles; Chapter 5 heavy vehicles; Chapter 6 alternative fuel vehicles; Chapter 7 fleet vehicles; Chapter 8 household vehicles; and Chapter 9 nonhighway modes; Chapter 10 transportation and the economy; Chapter 11 greenhouse gas emissions; and Chapter 12 criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  20. Transportation Energy Data Book: Edition 26

    Energy Technology Data Exchange (ETDEWEB)

    Davis, Stacy Cagle [ORNL; Diegel, Susan W [ORNL

    2007-07-01

    The Transportation Energy Data Book: Edition 26 is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of Planning, Budget Formulation, and Analysis, under the Energy Efficiency and Renewable Energy (EERE) program in the Department of Energy (DOE). Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. The latest editions of the Data Book are available to a larger audience via the Internet (cta.ornl.gov/data). This edition of the Data Book has 12 chapters which focus on various aspects of the transportation industry. Chapter 1 focuses on petroleum; Chapter 2 - energy; Chapter 3 - highway vehicles; Chapter 4 - light vehicles; Chapter 5 - heavy vehicles; Chapter 6 - alternative fuel vehicles; Chapter 7 - fleet vehicles; Chapter 8 - household vehicles; and Chapter 9- nonhighway modes; Chapter 10 - transportation and the economy; Chapter 11 - greenhouse gas emissions; and Chapter 12 - criteria pollutant emissions. The sources used represent the latest available data. There are also three appendices which include detailed source information for some tables, measures of conversion, and the definition of Census divisions and regions. A glossary of terms and a title index are also included for the readers convenience.

  1. Water quality management library. 2. edition

    Energy Technology Data Exchange (ETDEWEB)

    Eckenfelder, W.W.; Malina, J.F.; Patterson, J.W. [eds.

    1998-12-31

    A series of ten books offered in conjunction with Water Quality International, the Biennial Conference and Exposition of the International Association on Water Pollution Research and Control (IAWPRC). Volume 1, Activated Sludge Process, Design and Control, 2nd edition, 1998: Volume 2, Upgrading Wastewater Treatment Plants, 2nd edition, 1998: Volume 3, Toxicity Reduction, 2nd edition, 1998: Volume 4, Municipal Sewage Sludge Management, 2nd edition, 1998: Volume 5, Design and Retrofit of Wastewater Treatment Plants for Biological Nutrient Removal, 1st edition, 1992: Volume 6, Dynamics and Control of the Activated Sludge Process, 2nd edition, 1998: Volume 7: Design of Anaerobic Processes for the Treatment of Industrial and Municipal Wastes, 1st edition, 1992: Volume 8, Groundwater Remediation, 1st edition, 1992: Volume 9, Nonpoint Pollution and Urban Stormwater Management, 1st edition, 1995: Volume 10, Wastewater Reclamation and Reuse, 1st edition, 1998.

  2. Edit while watching: home video editing made easy

    Science.gov (United States)

    Campanella, Marco; Weda, Hans; Barbieri, Mauro

    2007-01-01

    In recent years, more and more people capture their experiences in home videos. However, home video editing still is a difficult and time-consuming task. We present the Edit While Watching system that allows users to automatically create and change a summary of a home video in an easy, intuitive and lean-back way. Based on content analysis, video is indexed, segmented, and combined with proper music and editing effects. The result is an automatically generated home video summary that is shown to the user. While watching it, users can indicate whether they like certain content, so that the system will adapt the summary to contain more content that is similar or related to the displayed content. During the video playback users can also modify and enrich the content, seeing immediately the effects of their changes. Edit While Watching does not require a complex user interface: a TV and a few keys of a remote control are sufficient. A user study has shown that it is easy to learn and to use, even if users expressed the need for more control in the editing operations and in the editing process.

  3. Loss of matK RNA editing in seed plant chloroplasts

    Directory of Open Access Journals (Sweden)

    Maier Uwe G

    2009-08-01

    Full Text Available Abstract Background RNA editing in chloroplasts of angiosperms proceeds by C-to-U conversions at specific sites. Nuclear-encoded factors are required for the recognition of cis-elements located immediately upstream of editing sites. The ensemble of editing sites in a chloroplast genome differs widely between species, and editing sites are thought to evolve rapidly. However, large-scale analyses of the evolution of individual editing sites have not yet been undertaken. Results Here, we analyzed the evolution of two chloroplast editing sites, matK-2 and matK-3, for which DNA sequences from thousands of angiosperm species are available. Both sites are found in most major taxa, including deep-branching families such as the nymphaeaceae. However, 36 isolated taxa scattered across the entire tree lack a C at one of the two matK editing sites. Tests of several exemplary species from this in silico analysis of matK processing unexpectedly revealed that one of the two sites remain unedited in almost half of all species examined. A comparison of sequences between editors and non-editors showed that specific nucleotides co-evolve with the C at the matK editing sites, suggesting that these nucleotides are critical for editing-site recognition. Conclusion (i Both matK editing sites were present in the common ancestor of all angiosperms and have been independently lost multiple times during angiosperm evolution. (ii The editing activities corresponding to matK-2 and matK-3 are unstable. (iii A small number of third-codon positions in the vicinity of editing sites are selectively constrained independent of the presence of the editing site, most likely because of interacting RNA-binding proteins.

  4. Fourth Generation Leptons and Muon $g-2$

    CERN Document Server

    Hou, Wei-Shu; Ma, Chien-Yi

    2008-01-01

    We consider the contributions to $g_\\mu-2$ from fourth generation heavy neutral and charged leptons, $N$ and $E$, at the one-loop level. Diagrammatically, there are two types of contributions: boson-boson-$N$, and $E$-$E$-boson in the loop diagram. In general, the effect from $N$ is suppressed by off-diagonal lepton mixing matrix elements. For $E$, we consider flavor changing neutral couplings arising from various New Physics models, which are stringently constrained by $\\mu\\to e\\gamma$. We assess how the existence of a fourth generation would affect these New Physics models.

  5. The Fourth (A)ATSR Data Reprocessing

    Science.gov (United States)

    Goryl, Philippe; Cocevar, Pauline; Done, Fay; Aatsr Quality Working Group

    2016-08-01

    This paper aims to inform users of the upcoming Fourth Reprocessing of ATSR-1, ATSR-2 and AATSR data. The main objective of the Fourth Reprocessing is to generate (A)ATSR Level 1B data products in a similar format to SLSTR products from Sentinel-3. In this way, users can easily access the 20-year dataset from the ERS and ENVISAT (A)ATSR missions and carry the analysis forward into the Sentinel era. In addition to the product format change, the dataset will build on the improvements implemented in the Third Reprocessing, and will contain further improvements and enhancements, as described below.

  6. JACOBI PSEUDOSPECTRAL METHOD FOR FOURTH ORDER PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Zheng-su Wan; Ben-yu Guo; Zhong-qing Wang

    2006-01-01

    In this paper, we investigate Jacobi pseudospectral method for fourth order problems.We establish some basic results on the Jacobi-Gauss-type interpolations in non-uniformly weighted Sobolev spaces, which serve as important tools in analysis of numerical quadratures, and numerical methods of differential and integral equations. Then we propose Jacobi pseudospectral schemes for several singular problems and multiple-dimensional problems of fourth order. Numerical results demonstrate the spectral accuracy of these schemes,and coincide well with theoretical analysis.

  7. Modern Physics, 4th edition

    Science.gov (United States)

    Tipler, Paul A.; Llewellyn, Ralph

    The new edition of the classic text for the intermediate-level modern physics course, revised and updated to take students to the forefront of contemporary research and applications across the full spectrum of science and technology."

  8. Native mitochondrial RNA-binding complexes in kinetoplastid RNA editing differ in guide RNA composition.

    Science.gov (United States)

    Madina, Bhaskara R; Kumar, Vikas; Metz, Richard; Mooers, Blaine H M; Bundschuh, Ralf; Cruz-Reyes, Jorge

    2014-07-01

    Mitochondrial mRNAs in kinetoplastids require extensive U-insertion/deletion editing that progresses 3'-to-5' in small blocks, each directed by a guide RNA (gRNA), and exhibits substrate and developmental stage-specificity by unsolved mechanisms. Here, we address compositionally related factors, collectively known as the mitochondrial RNA-binding complex 1 (MRB1) or gRNA-binding complex (GRBC), that contain gRNA, have a dynamic protein composition, and transiently associate with several mitochondrial factors including RNA editing core complexes (RECC) and ribosomes. MRB1 controls editing by still unknown mechanisms. We performed the first next-generation sequencing study of native subcomplexes of MRB1, immunoselected via either RNA helicase 2 (REH2), that binds RNA and associates with unwinding activity, or MRB3010, that affects an early editing step. The particles contain either REH2 or MRB3010 but share the core GAP1 and other proteins detected by RNA photo-crosslinking. Analyses of the first editing blocks indicate an enrichment of several initiating gRNAs in the MRB3010-purified complex. Our data also indicate fast evolution of mRNA 3' ends and strain-specific alternative 3' editing within 3' UTR or C-terminal protein-coding sequence that could impact mitochondrial physiology. Moreover, we found robust specific copurification of edited and pre-edited mRNAs, suggesting that these particles may bind both mRNA and gRNA editing substrates. We propose that multiple subcomplexes of MRB1 with different RNA/protein composition serve as a scaffold for specific assembly of editing substrates and RECC, thereby forming the editing holoenzyme. The MRB3010-subcomplex may promote early editing through its preferential recruitment of initiating gRNAs.

  9. Editing Fibroblast Growth Factor 5 Gene in Ovine Fibroblasts Using TALENs%TALENs编辑绵羊成纤维细胞FGF 5基因

    Institute of Scientific and Technical Information of China (English)

    皮文辉; 周平; 王立民; 唐红; 郭延华; 张译元; 刘守仁; 王新华

    2015-01-01

    类转录激活因子效应物(Transcription activator-like effector,TALE)已经成为基因组编辑和基因转录调控的有效工具,在多个物种的基因组中实现特定位点的删除、插入和突变.针对绵羊成纤维细胞生长因子5 (Fibroblast growth factor 5,FGF 5)基因起始密码子ATG位点,设计构建TALENs(Transcription activator-like effector nucleases,TALENs).通过比较分析正常培养和基因组编辑处理的绵羊成纤维细胞,电转TALENs组合,Surveyor突变检测,筛选获得1对有效的TALENs.有限稀释细胞传代培养,PCR扩增FGF 5基因片段,经PAGE检测筛选发生突变的细胞,测序确认FGF 5基因ATG位点产生缺失突变细胞.获得具有编辑活性的TALENs,为该基因的定点编辑奠定基础.Surveyor检测和测序结果表明,在绵羊FGF 5基因ATG起始密码子上游104碱基位点,存在1个G/C单核苷酸多态.

  10. Photovoltaic System Pricing Trends. Historical, Recent, and Near-Term Projections, 2015 Edition

    Energy Technology Data Exchange (ETDEWEB)

    Feldman, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Barbose, Galen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Margolis, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Bolinger, Mark [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Chung, Donald [National Renewable Energy Lab. (NREL), Golden, CO (United States); Fu, Ran [National Renewable Energy Lab. (NREL), Golden, CO (United States); Seel, Joachim [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Davidson, Carolyn [National Renewable Energy Lab. (NREL), Golden, CO (United States); Darghouth, Naïm [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wiser, Ryan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2015-08-25

    This presentation, based on research at Lawrence Berkeley National Laboratory and the National Renewable Energy Laboratory, provides a high-level overview of historical, recent, and projected near-term PV pricing trends in the United States focusing on the installed price of PV systems. It also attempts to provide clarity surrounding the wide variety of potentially conflicting data available about PV system prices. This PowerPoint is the fourth edition from this series.

  11. An Introduction to Object-Oriented Programming with JAVA, 4th Edition

    OpenAIRE

    Wu, C. Thomas

    2006-01-01

    An Introduction to Object-Oriented Programming with Java takes a full immersion approach to object-oriented programming. Proper object-oriented design practices are emphasized throughout the book. Students learn to be object users first, then learn to be class designers. In the fourth edition, we use a gentler approach to teaching students how to design their own classes, separating the coverage into two chapters.

  12. Foundations of Mechanics, Second Edition

    OpenAIRE

    1987-01-01

    Preface to the Second Edition. Since the first edition of this book appeared in 1967, there has been a great deal of activity in the field of symplectic geometry and Hamiltonian systems. In addition to the recent textbooks of Arnold, Arnold-Avez, Godbillon, Guillemin-Sternberg, Siegel-Moser, and Souriau, there have been many research articles published. Two good collections are "Symposia Mathematica," vol. XIV, and "Géométrie Symplectique el Physique Mathématique," CNRS, Colloque Intern...

  13. Genome editing in cardiovascular diseases.

    Science.gov (United States)

    Strong, Alanna; Musunuru, Kiran

    2017-01-01

    Genome-editing tools, which include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) systems, have emerged as an invaluable technology to achieve somatic and germline genomic manipulation in cells and model organisms for multiple applications, including the creation of knockout alleles, introducing desired mutations into genomic DNA, and inserting novel transgenes. Genome editing is being rapidly adopted into all fields of biomedical research, including the cardiovascular field, where it has facilitated a greater understanding of lipid metabolism, electrophysiology, cardiomyopathies, and other cardiovascular disorders, has helped to create a wider variety of cellular and animal models, and has opened the door to a new class of therapies. In this Review, we discuss the applications of genome-editing technology throughout cardiovascular disease research and the prospect of in vivo genome-editing therapies in the future. We also describe some of the existing limitations of genome-editing tools that will need to be addressed if cardiovascular genome editing is to achieve its full scientific and therapeutic potential.

  14. Singapore: The Fourth Way in Action?

    Science.gov (United States)

    Hargreaves, Andy

    2012-01-01

    This article has two main objectives. It first outlines the first three waves of change termed by Hargreaves and Shirley (The Fourth Way: The inspiring future for educational change. Thousand Oaks, CA: Corwin Press, "2009") as the First, Second and Third Way that defined global educational policy and practice since the 1960s. It then…

  15. Teaching Fourth Generation Evaluation through Monologue Interpretation.

    Science.gov (United States)

    Hepburn, Eric; Sparks, Cheryl

    1992-01-01

    This article illustrates the use of monologue interpretation, in which an interpreter illuminates issues in a speaker's monologue to translate theoretical pedagogical material into usable classroom applications. The example shows how the tenets of Guba and Lincoln's (1989) Responsive Constructivist Fourth Generation Model were presented via…

  16. The Fourth Basic: Computer Skills. Final Report.

    Science.gov (United States)

    Hardin County Board of Education, Elizabethtown, KY.

    Traditionally, the fundamental goal of all American education has been to provide students with adequate competencies in reading, writing, and mathematics. A year-long project, conducted at three high schools in Hardin County, Kentucky, provided for the development of a fourth basic: computer skills. Through this project, computer skills were…

  17. Vocabulary Strategies for a Fourth Grade Classroom

    Science.gov (United States)

    Howell, Gina

    2012-01-01

    For this project I worked with twelve of my fourth grade students from a local school in the southwestern part of Stokes County, North Carolina on increasing their vocabulary skills through the development and implementation of seven vocabulary strategies. During the Literature Review I came across the following seven strategies: Prediction;…

  18. An experiment with the fourth Futamura projection

    DEFF Research Database (Denmark)

    Glück, Robert

    2010-01-01

    We have experimentally validated the theoretical insight, that a compiler generator is an Ershov generating extension of a program specializer, by showing that an existing offline partial evaluator can perform the fourth Futamura projection. Specifically, an online and an offline partial evaluator...

  19. "Researching" with Third- and Fourth-Graders.

    Science.gov (United States)

    Liston, Barbara

    1970-01-01

    In order to instill in children the skills which will be basic to their school experience, words implying a process (such as "hemp,""parasite," and "vanilla") may be "researched" by third and fourth graders through the use of a dictionary, an encyclopedia, a supplementary book on the subject, and an interview with an adult. The child makes a…

  20. The Fourth Domain of Educational Objectives: Induction.

    Science.gov (United States)

    Holleman, Wes

    1985-01-01

    Tests the claim to comprehensiveness of Bloom's taxonomy of educational objectives by analyzing educational objectives of some freshmen orientation programs and those connected with human developmental tasks. It is concluded that the taxonomy should be enlarged with a fourth domain: actual induction into tasks for which students are being…

  1. Biomass Energy Data Book: Edition 1

    Energy Technology Data Exchange (ETDEWEB)

    Wright, Lynn L [ORNL; Boundy, Robert Gary [ORNL; Perlack, Robert D [ORNL; Davis, Stacy Cagle [ORNL; Saulsbury, Bo [ORNL

    2006-09-01

    The Biomass Energy Data Book is a statistical compendium prepared and published by Oak Ridge National Laboratory (ORNL) under contract with the Office of the Biomass Program and the Office of Planning, Budget and Analysis in the Department of Energy's Energy Efficiency and Renewable Energy (EERE) program. Designed for use as a desk-top reference, the book represents an assembly and display of statistics and information that characterize the biomass industry, from the production of biomass feedstocks to their end use. This is the first edition of the Biomass Energy Data Book and is currently only available online in electronic format. There are five main sections to this book. The first section is an introduction which provides an overview of biomass resources and consumption. Following the introduction to biomass is a section on biofuels which covers ethanol, biodiesel and BioOil. The biopower section focuses on the use of biomass for electrical power generation and heating. The fourth section is about the developing area of biorefineries, and the fifth section covers feedstocks that are produced and used in the biomass industry. The sources used represent the latest available data. There are also three appendices which include measures of conversions, biomass characteristics and assumptions for selected tables and figures. A glossary of terms and a list of acronyms are also included for the reader's convenience.

  2. Unveiling Chloroplast RNA Editing Events Using Next Generation Small RNA Sequencing Data

    Directory of Open Access Journals (Sweden)

    Nureyev F. Rodrigues

    2017-09-01

    Full Text Available Organellar RNA editing involves the modification of nucleotide sequences to maintain conserved protein functions, mainly by reverting non-neutral codon mutations. The loss of plastid editing events, resulting from mutations in RNA editing factors or through stress interference, leads to developmental, physiological and photosynthetic alterations. Recently, next generation sequencing technology has generated the massive discovery of sRNA sequences and expanded the number of sRNA data. Here, we present a method to screen chloroplast RNA editing using public sRNA libraries from Arabidopsis, soybean and rice. We mapped the sRNAs against the nuclear, mitochondrial and plastid genomes to confirm predicted cytosine to uracil (C-to-U editing events and identify new editing sites in plastids. Among the predicted editing sites, 40.57, 34.78, and 25.31% were confirmed using sRNAs from Arabidopsis, soybean and rice, respectively. SNP analysis revealed 58.2, 43.9, and 37.5% new C-to-U changes in the respective species and identified known and new putative adenosine to inosine (A-to-I RNA editing in tRNAs. The present method and data reveal the potential of sRNA as a reliable source to identify new and confirm known editing sites.

  3. TbRGG2 facilitates kinetoplastid RNA editing initiation and progression past intrinsic pause sites.

    Science.gov (United States)

    Ammerman, Michelle L; Presnyak, Vladimir; Fisk, John C; Foda, Bardees M; Read, Laurie K

    2010-11-01

    TbRGG2 is an essential kinetoplastid RNA editing accessory factor that acts specifically on pan-edited RNAs. To understand the mechanism of TbRGG2 action, we undertook an in-depth analysis of edited RNA populations in TbRGG2 knockdown cells and an in vitro examination of the biochemical activities of the protein. We demonstrate that TbRGG2 down-regulation more severely impacts editing at the 5' ends of pan-edited RNAs than at their 3' ends. The initiation of editing is reduced to some extent in TbRGG2 knockdown cells. In addition, TbRGG2 plays a post-initiation role as editing becomes stalled in TbRGG2-depleted cells, resulting in an overall decrease in the 3' to 5' progression of editing. Detailed analyses of edited RNAs from wild-type and TbRGG2-depleted cells reveal that TbRGG2 facilitates progression of editing past intrinsic pause sites that often correspond to the 3' ends of cognate guide RNAs (gRNAs). In addition, noncanonically edited junction regions are either absent or significantly shortened in TbRGG2-depleted cells, consistent with impaired gRNA transitions. Sequence analysis further suggests that TbRGG2 facilitates complete utilization of certain gRNAs. In vitro RNA annealing and in vivo RNA unwinding assays demonstrate that TbRGG2 can modulate RNA-RNA interactions. Collectively, these data are consistent with a model in which TbRGG2 facilitates initiation and 3' to 5' progression of editing through its ability to affect gRNA utilization, both during the transition between specific gRNAs and during usage of certain gRNAs.

  4. Incremental validity of WISC-IV(UK) factor index scores with a referred Irish sample: predicting performance on the WIAT-II(UK.).

    Science.gov (United States)

    Canivez, Gary L; Watkins, Marley W; James, Trevor; Good, Rebecca; James, Kate

    2014-12-01

    Subtest and factor scores have typically provided little incremental predictive validity beyond the omnibus IQ score. This study examined the incremental validity of Wechsler Intelligence Scale for Children - Fourth UK Edition (WISC-IV(UK) ; Wechsler, 2004a, Wechsler Intelligence Scale for Children - Fourth UK Edition, Harcourt Assessment, London, UK) and factor index scores in predicting academic achievement on the Wechsler Individual Achievement Test - Second UK Edition (WIAT-II(UK) ; Wechsler, 2005a, Wechsler Individual Achievement Test-Second UK Edition, Pearson, London, UK), beyond that predicted by the WISC-IV(UK) FSIQ. The sample included 1,014 Irish children (ages 6-0 to 16-9) who were referred for evaluation of learning difficulties. Hierarchical multiple regression analyses were used with the WISC-IV(UK) FSIQ (Block 1) and factor index scores (Block 2) as predictors and WIAT-II(UK) subtest and composite scores as dependent variables. The WISC-IV(UK) FSIQ accounted for statistically significant and generally large portions of WIAT-II(UK) subtest and composite score variance. WISC-IV(UK) factor index scores combined to provide statistically significant increments in prediction of most WIAT-II(UK) subtest and composite scores over and above the FSIQ; however, the effect sizes were mostly small as previously observed (i.e., Canivez, 2013a, Psychol. Assess., 25, 484; Glutting et al., 2006, J. Spec. Educ., 40, 103; Nelson et al., 2013, Psychol. Assess., 25, 618). Individually, the WISC-IV(UK) factor index scores provided small unique contributions to predicting WIAT-II(UK) scores. This, in combination with studies of apportioned variance from bifactor confirmatory factor analysis (Watkins et al., 2013, Int. J. Sch. Educ. Psychol., 1, 102), indicated that the WISC-IV(UK) FSIQ should retain the greatest weight in WISC-IV(UK) interpretation. © 2014 The British Psychological Society.

  5. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan

    2011-12-12

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed highlevel operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques. © 2011 ACM.

  6. Connectivity editing for quadrilateral meshes

    KAUST Repository

    Peng, Chihan

    2011-12-01

    We propose new connectivity editing operations for quadrilateral meshes with the unique ability to explicitly control the location, orientation, type, and number of the irregular vertices (valence not equal to four) in the mesh while preserving sharp edges. We provide theoretical analysis on what editing operations are possible and impossible and introduce three fundamental operations to move and re-orient a pair of irregular vertices. We argue that our editing operations are fundamental, because they only change the quad mesh in the smallest possible region and involve the fewest irregular vertices (i.e., two). The irregular vertex movement operations are supplemented by operations for the splitting, merging, canceling, and aligning of irregular vertices. We explain how the proposed high-level operations are realized through graph-level editing operations such as quad collapses, edge flips, and edge splits. The utility of these mesh editing operations are demonstrated by improving the connectivity of quad meshes generated from state-of-art quadrangulation techniques.

  7. [Genome editing of industrial microorganism].

    Science.gov (United States)

    Zhu, Linjiang; Li, Qi

    2015-03-01

    Genome editing is defined as highly-effective and precise modification of cellular genome in a large scale. In recent years, such genome-editing methods have been rapidly developed in the field of industrial strain improvement. The quickly-updating methods thoroughly change the old mode of inefficient genetic modification, which is "one modification, one selection marker, and one target site". Highly-effective modification mode in genome editing have been developed including simultaneous modification of multiplex genes, highly-effective insertion, replacement, and deletion of target genes in the genome scale, cut-paste of a large DNA fragment. These new tools for microbial genome editing will certainly be applied widely, and increase the efficiency of industrial strain improvement, and promote the revolution of traditional fermentation industry and rapid development of novel industrial biotechnology like production of biofuel and biomaterial. The technological principle of these genome-editing methods and their applications were summarized in this review, which can benefit engineering and construction of industrial microorganism.

  8. CTD writing and editing standards

    Science.gov (United States)

    Caruthers, C. M.

    1991-03-01

    The Computer and Telecommunication Division (CTD) recognizes that the communication of clear, accurate, reasonably complete information is essential to the success of its Laboratory mission. CTD therefore encourages all Division personnel to adhere to the principles of good writing and to the standards for grammar, usage, style, formats, and publication procedures that are described in CTD Writing and Editing Standards. We encourage CTD personnel to read CTD Writing and Editing Standards and to use it continually as a desktop reference. It will help CTD writers to produce better documents consistent with CTD standards in less time. Applying the principles specified in this document on how to write and organize technical information will speed up the editing, review, and revision processes. CTD Writing and Editing Standards complements the Argonne National Laboratory Technical Publications Guide, which serves as the basic Argonne documentation reference on issues concerning DOE orders and guidelines, NRC directives, and other sponsor requirements. However, this Laboratory-wide document does not address matters of grammar or style. Documents recommended in CTD Writing and Editing Standards are usually available for purchase at the Document Distribution Counter (Building 221, Room A-134) or through the mail (by calling extension 2-5405 and ordering copies).

  9. Using fourth-generation evaluation in nursing.

    Science.gov (United States)

    Swenson, M M

    1991-03-01

    Evaluation is disciplined inquiry undertaken to determine the value, including merit and worth, of some entity: a curriculum program, a clinical intervention, an academic course, a care plan. An evaluation is conducted to improve or refine the thing being evaluated (evaluand) or to assess its impact and effectiveness. Evaluation in nursing has been designed using various positivistic and post-positivistic models in the first three "generations" in the evolution of evaluation practice. This article describes a new model of nursing evaluation more consistent with a nursing paradigm than with a traditional, scientific, medical paradigm. Responsive nursing evaluation informs and empowers all those involved in its outcomes (the stakeholders) when framed within the research stance called naturalistic or constructivist inquiry. The fourth-generation-evaluation approach of Guba and Lincoln (1989) is consistent with a nursing paradigm and a constructivist approach. Fourth-generation evaluation is presented with specific application to nursing evaluation.

  10. The Fourth Law of Behavior Genetics.

    Science.gov (United States)

    Chabris, Christopher F; Lee, James J; Cesarini, David; Benjamin, Daniel J; Laibson, David I

    2015-07-01

    Behavior genetics is the study of the relationship between genetic variation and psychological traits. Turkheimer (2000) proposed "Three Laws of Behavior Genetics" based on empirical regularities observed in studies of twins and other kinships. On the basis of molecular studies that have measured DNA variation directly, we propose a Fourth Law of Behavior Genetics: "A typical human behavioral trait is associated with very many genetic variants, each of which accounts for a very small percentage of the behavioral variability." This law explains several consistent patterns in the results of gene discovery studies, including the failure of candidate gene studies to robustly replicate, the need for genome-wide association studies (and why such studies have a much stronger replication record), and the crucial importance of extremely large samples in these endeavors. We review the evidence in favor of the Fourth Law and discuss its implications for the design and interpretation of gene-behavior research.

  11. The "fourth dimension" of gene transcription.

    Science.gov (United States)

    O'Malley, Bert W

    2009-05-01

    The three dimensions of space provide our relationship to position on the earth, but the fourth dimension of time has an equally profound influence on our lives. Everything from light and sound to weather and biology operate on the principle of measurable temporal periodicity. Consequently, a wide variety of time clocks affect all aspects of our existence. The annual (and biannual) cycles of activity, metabolism, and mating, the monthly physiological clocks of women and men, and the 24-h diurnal rhythms of humans are prime examples. Should it be surprising to us that the fourth dimension also impinges upon gene expression and that the genome itself is regulated by the fastest running of all biological clocks? Recent evidence substantiates the existence of such a ubiquitin-dependent transcriptional clock that is based upon the activation and destruction of transcriptional coactivators.

  12. Imitatio Christi in the fourth gospel

    Directory of Open Access Journals (Sweden)

    D.G. van der Merwe

    2001-08-01

    Full Text Available Imitatio Christi is a concept which, although not referred to explicitly in the Fourth Gospel, is clearly spelled out in relation to the agency motif occurring in the Gospel. The disciples of Jesus have been appointed as his agents to continue his mission after his departure to his Father. In giving this message through to his readers, the Fourth Evangelist refers to Jesus' calling of his disciples, [Foreign font omitted]; pictures Jesus as [Foreign font omitted]; uses [Foreign font omitted] (the particle of comparison to compare the lives of the disciples with that of Jesus; points out the tasks the disciples had to perform after Jesus' ascension and, finally, indicates how Jesus dwells in his disciples through the Paraclete.

  13. Coping with Downsizing as a Writing and Editing Group.

    Science.gov (United States)

    Steve, Mike; Bigelow, Tom

    1993-01-01

    Maintains that writers and editors are likely candidates for downsizing within an organization. Notes that centralization-decentralization factors are valuable in addressing downsizing, as is knowledge of corporate management's point of view toward its investment in writing and editing. Offers five self-assessment scenarios to help prepare for the…

  14. Coping with Downsizing as a Writing and Editing Group.

    Science.gov (United States)

    Steve, Mike; Bigelow, Tom

    1993-01-01

    Maintains that writers and editors are likely candidates for downsizing within an organization. Notes that centralization-decentralization factors are valuable in addressing downsizing, as is knowledge of corporate management's point of view toward its investment in writing and editing. Offers five self-assessment scenarios to help prepare for the…

  15. The Mass Media and Modern Society. Second Edition.

    Science.gov (United States)

    Rivers, William L.; And Others

    The focus throughout this second edition is on the 1970's and the impact of mass communication on contemporary society. Analyzing the ways in which communication affects and is, in turn, affected by society, the book examines the social, economic, and intellectual environments in which the media operate. Two intellectual factors which have had the…

  16. Understanding Editing Behaviors in Multilingual Wikipedia.

    Directory of Open Access Journals (Sweden)

    Suin Kim

    Full Text Available Multilingualism is common offline, but we have a more limited understanding of the ways multilingualism is displayed online and the roles that multilinguals play in the spread of content between speakers of different languages. We take a computational approach to studying multilingualism using one of the largest user-generated content platforms, Wikipedia. We study multilingualism by collecting and analyzing a large dataset of the content written by multilingual editors of the English, German, and Spanish editions of Wikipedia. This dataset contains over two million paragraphs edited by over 15,000 multilingual users from July 8 to August 9, 2013. We analyze these multilingual editors in terms of their engagement, interests, and language proficiency in their primary and non-primary (secondary languages and find that the English edition of Wikipedia displays different dynamics from the Spanish and German editions. Users primarily editing the Spanish and German editions make more complex edits than users who edit these editions as a second language. In contrast, users editing the English edition as a second language make edits that are just as complex as the edits by users who primarily edit the English edition. In this way, English serves a special role bringing together content written by multilinguals from many language editions. Nonetheless, language remains a formidable hurdle to the spread of content: we find evidence for a complexity barrier whereby editors are less likely to edit complex content in a second language. In addition, we find that multilinguals are less engaged and show lower levels of language proficiency in their second languages. We also examine the topical interests of multilingual editors and find that there is no significant difference between primary and non-primary editors in each language.

  17. Description scheme for video editing work

    Science.gov (United States)

    Ruiloba, Rosa I.; Joly, Philippe

    2001-03-01

    This article presents a Description Scheme (DS) to describe the audio-visual documents from the video editing work point of view. This DS is based on edition techniques used in the video edition domain. The main objective of this DS is to provide a complete, modular and extensible description of the structure of the video documents based on editing process. This VideoEditing DS is generic in the sense that it may be used in a large number of applications such as video document indexing and analysis, description of Edit Decision List and elaboration of editing patterns. It is based on accurate and complete definitions of shots and transition effects required for video document analysis applications. The VideoEditing DS allows three levels of description : analytic, synthetic and semantic. In the DS, the higher (resp. the lower) is the element of description, the more analytic (resp. synthetic) is the information. %Phil This DS allows describing the editing work made by editing boards, using more detailed descriptors of Shots and Transition DSs. These elements are provided to define editing patterns that allow several possible reconstructions of movies depending on, for example, the target audience. A part of the video description made with this DS may be automatically produced by the video to shots segmentation algorithms (analytic DSs ) or by editing software, at the same time the edition work is made. This DS gives an answer to the needs related to the exchange of editing work descriptions between editing softwares. At the same time, the same DS provide an analytic description of editing work which is complementary to existing standards for Edit Decision Lists like SMPTE or AAF.

  18. Understanding Editing Behaviors in Multilingual Wikipedia.

    Science.gov (United States)

    Kim, Suin; Park, Sungjoon; Hale, Scott A; Kim, Sooyoung; Byun, Jeongmin; Oh, Alice H

    2016-01-01

    Multilingualism is common offline, but we have a more limited understanding of the ways multilingualism is displayed online and the roles that multilinguals play in the spread of content between speakers of different languages. We take a computational approach to studying multilingualism using one of the largest user-generated content platforms, Wikipedia. We study multilingualism by collecting and analyzing a large dataset of the content written by multilingual editors of the English, German, and Spanish editions of Wikipedia. This dataset contains over two million paragraphs edited by over 15,000 multilingual users from July 8 to August 9, 2013. We analyze these multilingual editors in terms of their engagement, interests, and language proficiency in their primary and non-primary (secondary) languages and find that the English edition of Wikipedia displays different dynamics from the Spanish and German editions. Users primarily editing the Spanish and German editions make more complex edits than users who edit these editions as a second language. In contrast, users editing the English edition as a second language make edits that are just as complex as the edits by users who primarily edit the English edition. In this way, English serves a special role bringing together content written by multilinguals from many language editions. Nonetheless, language remains a formidable hurdle to the spread of content: we find evidence for a complexity barrier whereby editors are less likely to edit complex content in a second language. In addition, we find that multilinguals are less engaged and show lower levels of language proficiency in their second languages. We also examine the topical interests of multilingual editors and find that there is no significant difference between primary and non-primary editors in each language.

  19. Fourth international conference on Networks & Communications

    CERN Document Server

    Meghanathan, Natarajan; Nagamalai, Dhinaharan; Computer Networks & Communications (NetCom)

    2013-01-01

    Computer Networks & Communications (NetCom) is the proceedings from the Fourth International Conference on Networks & Communications. This book covers theory, methodology and applications of computer networks, network protocols and wireless networks, data communication technologies, and network security. The proceedings will feature peer-reviewed papers that illustrate research results, projects, surveys and industrial experiences that describe significant advances in the diverse areas of computer networks & communications.

  20. On a fourth order superlinear elliptic problem

    Directory of Open Access Journals (Sweden)

    M. Ramos

    2001-01-01

    Full Text Available We prove the existence of a nonzero solution for the fourth order elliptic equation $$Delta^2u= mu u +a(xg(u$$ with boundary conditions $u=Delta u=0$. Here, $mu$ is a real parameter, $g$ is superlinear both at zero and infinity and $a(x$ changes sign in $Omega$. The proof uses a variational argument based on the argument by Bahri-Lions cite{BL}.

  1. Fourth World Theory: The Evolution of . . .

    OpenAIRE

    2014-01-01

    Fourth World theory is a methodology for examining and developing greater understanding of the extent of the distress and abandonment commonly found in the cores of American cities resulting from de-industrialization, historic segregation and discrimination patterns, suburban sprawl, erosion of a viable tax base, racism, inability to embrace the concept of desegregation and civil rights legislation, fear, despair, crumbling infrastructure systems, disinvestment in urban school systems, and en...

  2. Supernumerary maxillary and Mandibular Fourth Molars.

    Science.gov (United States)

    1981-09-23

    in earlier primates then in man. Hyperdontia has occasionally been associated with clefts of the lip and palate , I0 cleldocranial dysostosis, 2...year-old black male was seen In the clinic for treatment of pain which was originating from a deep carious lesion in the mandibular left second molar...incompletely formed impacted left fourth molar and right bicuspid were also noted. Case III. A 24-year-old male was seen in the clinic for treatment of

  3. The fourth China Bioanalysis Forum Annual Meeting.

    Science.gov (United States)

    Tang, Daniel; Zhong, Dafang; Dong, Kelly

    2017-01-01

    The fourth China Bioanalysis Forum annual conference, co-organized with the Nanjing International Drug Metabolism Conference, was successfully held in Nanjing, China, between 24-26 June 2016. The theme of the conference was 'how to conduct regulated bioanalysis under China Food and Drug Administration (CFDA) regulations'. In addition, several hot topics including bioanalytical challenges, solutions for biomarkers, antidrug antibody (antibody-drug conjugates) and biologics were discussed. This Conference Report summarizes the major discussion topics from the conference.

  4. Art meets mathematics in the fourth dimension

    CERN Document Server

    Lipscomb, Stephen Leon

    2014-01-01

    To see objects that live in the fourth dimension we humans would need to add a fourth dimension to our three-dimensional vision. An example of such an object that lives in the fourth dimension is a hyper-sphere or “3-sphere”. The quest to imagine the elusive 3-sphere has deep historical roots: medieval poet Dante Alighieri, in his circa 1300 AD Divine Comedy, used a 3-sphere to convey his allegorical vision of the Christian afterlife. In 1917, Albert Einstein visualized the universe, at each instant in time, as a 3-sphere. He described his representation as “…the place where the reader’s imagination boggles. Nobody can imagine this thing.” Over time, however, our understanding of the concept of dimension evolved. By 2003, a researcher had successfully rendered into human vision the structure of a 4-web (think of an every increasingly-dense spider’s web). In this text Stephen Lipscomb takes his innovative dimension theory research a step further, using the 4-web to reveal a new partial image of a...

  5. Telling time in the Fourth Gospel

    Directory of Open Access Journals (Sweden)

    Jerome H. Neyrey

    2008-01-01

    Full Text Available When we begin the task of telling time in the Fourth Gospel, we bring something not found in any previous study, namely, a model of time articulated by cross- ultural anthropologists (Bordieu, in Pitt-Rivers 1963:55-72, Ayoade, in Wright 1984:71-89. As much as we admire Davies’ study, she has no notes to her chapter on time nor any citations in her bibliography to indicate that she has any conversation partners, much less cultural experts, a deficit to be filled in this study. Learning to tell time entails three theoretical considerations: a definition of time, key classifications of it, and special attention to what the ancients meant by past, present and future. With these lenses we are prepared to do as thorough a study as we can on telling time in the Fourth Gospel. As we consider each classification, we will suggest a brief meaning of it from the experts on time, then present a body of Greco-Roman materials illustrative of the classification, and finally use it to gather and interpret data in John. Proving the native existence of these classifications for telling time in antiquity is essential for readers to have a background against which to compare their usage with that of the Fourth Gospel.

  6. Fourth order difference methods for hyperbolic IBVP's

    Science.gov (United States)

    Gustafsson, Bertil; Olsson, Pelle

    1994-01-01

    Fourth order difference approximations of initial-boundary value problems for hyperbolic partial differential equations are considered. We use the method of lines approach with both explicit and compact implicit difference operators in space. The explicit operator satisfies an energy estimate leading to strict stability. For the implicit operator we develop boundary conditions and give a complete proof of strong stability using the Laplace transform technique. We also present numerical experiments for the linear advection equation and Burgers' equation with discontinuities in the solution or in its derivative. The first equation is used for modeling contact discontinuities in fluid dynamics, the second one for modeling shocks and rarefaction waves. The time discretization is done with a third order Runge-Kutta TVD method. For solutions with discontinuities in the solution itself we add a filter based on second order viscosity. In case of the non-linear Burger's equation we use a flux splitting technique that results in an energy estimate for certain different approximations, in which case also an entropy condition is fulfilled. In particular we shall demonstrate that the unsplit conservative form produces a non-physical shock instead of the physically correct rarefaction wave. In the numerical experiments we compare our fourth order methods with a standard second order one and with a third order TVD-method. The results show that the fourth order methods are the only ones that give good results for all the considered test problems.

  7. Latent variable models an introduction to factor, path, and structural equation analysis

    CERN Document Server

    Loehlin, John C

    2004-01-01

    This fourth edition introduces multiple-latent variable models by utilizing path diagrams to explain the underlying relationships in the models. The book is intended for advanced students and researchers in the areas of social, educational, clinical, ind

  8. [An introduction on the editions of Zhang Gao's Yi shuo (Medical Narrations)].

    Science.gov (United States)

    Wang, Xuguang; Lu, Xiang

    2014-11-01

    Zhang Gao's Yi shuo (Medical Narrations) of the Southern Song Dynasty had 2 kinds of editions: domestic editions and foreign editions. The former includes 1 Song edition, 14 Ming editions, 3 Qing editions and 25 editions after the Republic of China. The latter, mainly 2 classes, the Japanese edition and Korean printing type edition. In the Ming Dynasty, the editions of Yi shuo generated 2 branches: inherited edition and supplementary edition. The inherited editions include Gu Dingfang's edition, Zhang Yaode's edition, Wu Mianxue's edition, Wu Zhongheng's edition, Wang Kentang's edition, editions from Si ku quan shu (Imperial Collection of Four), stereotype edition of the 3th year of Xuantong reign (1911) from Shanghai Civilization Bookstore, edition of the 2(nd) year of Manji of Japan etc. The supplemental editions include Zhang Zili's edition, Shen Fan's edition, Fu Feng'ao's edition, transcript of the late Ming Dynasty preserved in the Library of Peking University, and Korean printing type edition etc.

  9. Boneless Pose Editing and Animation

    DEFF Research Database (Denmark)

    Bærentzen, Jakob Andreas; Hansen, Kristian Evers; Erleben, Kenny

    2007-01-01

    In this paper, we propose a pose editing and animation method for triangulated surfaces based on a user controlled partitioning of the model into deformable parts and rigid parts which are denoted handles. In our pose editing system, the user can sculpt a set of poses simply by transforming...... the handles for each pose. Using Laplacian editing, the deformable parts are deformed to match the handles. In our animation system the user can constrain one or several handles in order to define a new pose. New poses are interpolated from the examples poses, by solving a small non-linear optimization...... problem in order to obtain the interpolation weights. While the system can be used simply for building poses, it is also an animation system. The user can specify a path for a given constraint and the model is animated correspondingly....

  10. Genome-editing tools for stem cell biology.

    Science.gov (United States)

    Vasileva, E A; Shuvalov, O U; Garabadgiu, A V; Melino, G; Barlev, N A

    2015-07-23

    Human pluripotent stem cells provide a versatile platform for regenerative studies, drug testing and disease modeling. That the expression of only four transcription factors, Oct4, Klf4, Sox2 and c-Myc (OKSM), is sufficient for generation of induced pluripotent stem cells (iPSCs) from differentiated somatic cells has revolutionized the field and also highlighted the importance of OKSM as targets for genome editing. A number of novel genome-editing systems have been developed recently. In this review, we focus on successful applications of several such systems for generation of iPSCs. In particular, we discuss genome-editing systems based on zinc-finger fusion proteins (ZFs), transcription activator-like effectors (TALEs) and an RNA-guided DNA-specific nuclease, Cas9, derived from the bacterial defense system against viruses that utilizes clustered regularly interspaced short palindromic repeats (CRISPR).

  11. Gas Metal Arc Welding and Flux-Cored Arc Welding. Third Edition. Teacher Edition [and] Student Edition [and] Student Workbook.

    Science.gov (United States)

    Knapp, John; Harper, Eddie

    This packet, containing a teacher's edition, a student edition, and a student workbook, introduces students to high deposition welding and processes for "shielding" a weld. In addition to general information, the teacher edition consists of introductory pages and teacher pages, as well as unit information that corresponds to the…

  12. Gas Tungsten Arc Welding and Plasma Arc Cutting. Teacher Edition [and] Student Edition [and] Student Workbook. Second Edition.

    Science.gov (United States)

    Harper, Eddie; Knapp, John

    This packet of instructional materials for a gas tungsten arc welding (GTAW) and plasma arc cutting course is comprised of a teacher edition, student edition, and student workbook. The teacher edition consists of introductory pages and teacher pages. Introductory pages include training and competency profile, state duty/task crosswalk,…

  13. Isotope-edited infrared spectroscopy.

    Science.gov (United States)

    Buchner, Ginka S; Kubelka, Jan

    2012-01-01

    Isotope-edited infrared (IR) spectroscopy is a powerful tool for studying structural and dynamical properties of peptides and proteins with site-specific resolution. Labeling of selected amide carbonyls with (13)C results in detectable sidebands of amide I' vibrations, which provide information about local conformation and/or solvent exposure without structural perturbation to the protein. Incorporation of isotopically labeled amino acids at specific positions is achieved by the chemical synthesis of the studied proteins. We describe the basic procedures for synthesis of (13)C isotopically edited protein samples, experimental IR spectroscopic measurements, and analysis of the site-specific structural changes from the thermal unfolding IR data.

  14. Delivery technologies for genome editing.

    Science.gov (United States)

    Yin, Hao; Kauffman, Kevin J; Anderson, Daniel G

    2017-03-24

    With the recent development of CRISPR technology, it is becoming increasingly easy to engineer the genome. Genome-editing systems based on CRISPR, as well as transcription activator-like effector nucleases (TALENs) and zinc-finger nucleases (ZFNs), are becoming valuable tools for biomedical research, drug discovery and development, and even gene therapy. However, for each of these systems to effectively enter cells of interest and perform their function, efficient and safe delivery technologies are needed. This Review discusses the principles of biomacromolecule delivery and gene editing, examines recent advances and challenges in non-viral and viral delivery methods, and highlights the status of related clinical trials.

  15. Beginning XML, 5th Edition

    CERN Document Server

    Fawcett, Joe; Quin, Liam R E

    2012-01-01

    A complete update covering the many advances to the XML language The XML language has become the standard for writing documents on the Internet and is constantly improving and evolving. This new edition covers all the many new XML-based technologies that have appeared since the previous edition four years ago, providing you with an up-to-date introductory guide and reference. Packed with real-world code examples, best practices, and in-depth coverage of the most important and relevant topics, this authoritative resource explores both the advantages and disadvantages of XML and addresses the mo

  16. Genome editing comes of age.

    Science.gov (United States)

    Kim, Jin-Soo

    2016-09-01

    Genome editing harnesses programmable nucleases to cut and paste genetic information in a targeted manner in living cells and organisms. Here, I review the development of programmable nucleases, including zinc finger nucleases (ZFNs), TAL (transcription-activator-like) effector nucleases (TALENs) and CRISPR (cluster of regularly interspaced palindromic repeats)-Cas9 (CRISPR-associated protein 9) RNA-guided endonucleases (RGENs). I specifically highlight the key advances that set the foundation for the rapid and widespread implementation of CRISPR-Cas9 genome editing approaches that has revolutionized the field.

  17. Medical writing, revising and editing

    DEFF Research Database (Denmark)

    Pilegaard, Morten

    2006-01-01

    The globalization of science makes medical writing, editing and revision a rapidly growing field of linguistic study and practice. Medical science texts are written according to uniform, general guidelines and medical genres have become highly conventionalized in terms of structure and linguistic...... form. Medical editing often takes the form of peer review and mainly addresses issues of contents and overall validity. Medical revision incorporates the checking of the macrostructure and the microstructure of the text, its language and style and its suitability for the target reader or client...

  18. Language Editing at Astronomy & Astrophysics

    Science.gov (United States)

    Adams, J.

    2011-07-01

    In 2002, the A&A Board of Directors voted that all articles must be written in English and decided to improve the overall quality of the language in the articles with the help of a team of language editors. This article reviews the general advantages of editing the English expression and describes both the aims of this effort and its place in the full publication process. This is followed by the Guide to language editing that has been available on the Journal's website for several years now.

  19. Handbook of ecotoxicology, second edition

    Science.gov (United States)

    Hoffman, David J.; Rattner, Barnett A.; Burton, G. Allen; Cairns, John

    2003-01-01

    Handbook of Ecotoxicology, Second Edition focuses on toxic substances and how they affect ecosystems worldwide. It presents methods for quantifying and measuring ecotoxicological effects in the field and in the lab, as well as methods for estimating, predicting, and modeling in ecotoxicology studies. Completely revised and updated with 18 new chapters, this second edition includes contributions from over 75 international experts. Also, a Technical Review Board reviewed all manuscripts for accuracy and currency. This authoritative work is the definitive reference for students, researchers, consultants, and other professionals in the environmental sciences, toxicology, chemistry, biology, and ecology - in academia, industry, and government.

  20. Introducing ZBrush 3rd Edition

    CERN Document Server

    Keller, Eric

    2012-01-01

    Learn ZBrush inside and out with this updated new edition Get totally comfortable sculpting in a digital environment with the latest edition of this bestselling beginner's guide to ZBrush. Fully updated for the newest version of the software, ZBrush 4R3, this book dispels any fears you might have about the difficulty of using ZBrush and soon has you creating realistic, cartoon, and organic models with flair. Learn all the essentials, as you complete fun tutorials on painting, meshes, organic scripting, hard surface sculpting, lighting, rendering, and more. Introduces you to ZBrush, the sculpt

  1. Medical writing, revising and editing

    DEFF Research Database (Denmark)

    Pilegaard, Morten

    2006-01-01

    The globalization of science makes medical writing, editing and revision a rapidly growing field of linguistic study and practice. Medical science texts are written according to uniform, general guidelines and medical genres have become highly conventionalized in terms of structure and linguistic...... form. Medical editing often takes the form of peer review and mainly addresses issues of contents and overall validity. Medical revision incorporates the checking of the macrostructure and the microstructure of the text, its language and style and its suitability for the target reader or client...

  2. Power Product Equipment Technician: Equipment Systems. Teacher Edition. Student Edition.

    Science.gov (United States)

    Hilley, Robert

    This packet contains teacher and student editions on the topic of equipment systems, intended for the preparation of power product equipment technicians. This publication contains seven units: (1) principles of power transmission; (2) mechanical drive systems; (3) principles of fluid power; (4) hydraulic and pneumatic drive systems; (5) wheel and…

  3. Human Genome Editing and Ethical Considerations.

    Science.gov (United States)

    Krishan, Kewal; Kanchan, Tanuj; Singh, Bahadur

    2016-04-01

    Editing human germline genes may act as boon in some genetic and other disorders. Recent editing of the genome of the human embryo with the CRISPR/Cas9 editing tool generated a debate amongst top scientists of the world for the ethical considerations regarding its effect on the future generations. It needs to be seen as to what transformation human gene editing brings to humankind in the times to come.

  4. Strategies of Qualitative Inquiry. Third Edition

    Science.gov (United States)

    Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

    2007-01-01

    "Strategies of Qualitative Inquiry, Third Edition," the second volume in the paperback version of "The SAGE Handbook of Qualitative Research, 3rd Edition," consists of Part III of the handbook ("Strategies of Inquiry"). "Strategies of Qualitative Inquiry, Third Edition" presents the major tactics--historically, the research methods--that…

  5. 7 CFR 51.2296 - Three-fourths half kernel.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Three-fourths half kernel. 51.2296 Section 51.2296 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards...-fourths half kernel. Three-fourths half kernel means a portion of a half of a kernel which has more...

  6. Veterinary Microbiology, 3rd Edition

    Science.gov (United States)

    Veterinary Microbiology, Third Edition is organized into four sections and begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral d...

  7. Money and Schools. Fifth Edition

    Science.gov (United States)

    Thompson, David C.; Crampton, Faith E.; Wood, R. Craig

    2012-01-01

    In the new edition of this essential, all-inclusive text, the authors provide more important research for future principals and others enrolled in graduate-level school finance courses. Written in a style that is highly readable, the book offers strong connections to real-world experiences. Readers get both a broad overview of funding concepts and…

  8. Testing post-editing guidelines

    DEFF Research Database (Denmark)

    Flanagan, Marian; Christensen, Tina Paulsen

    2014-01-01

    There is a growing interest in machine translation (MT) and post-editing (PE). MT has been around for decades, but the use of the technology has grown significantly in the language industry in recent years, while PE is still a relatively new task. Consequently, there are currently no standard PE ...

  9. Money and Schools. Fifth Edition

    Science.gov (United States)

    Thompson, David C.; Crampton, Faith E.; Wood, R. Craig

    2012-01-01

    In the new edition of this essential, all-inclusive text, the authors provide more important research for future principals and others enrolled in graduate-level school finance courses. Written in a style that is highly readable, the book offers strong connections to real-world experiences. Readers get both a broad overview of funding concepts and…

  10. Prospective investigation of penile length with newborn male circumcision and second to fourth digit ratio

    Science.gov (United States)

    Park, Jong Kwan; Doo, A. Ram; Kim, Joo Heung; Park, Hyung Sub; Do, Jung Mo; Choi, Hwang; Park, Seung Chol; Kim, Myung Ki; Jeong, Young Beom; Kim, Hyung Jim; Kim, Young Gon; Shin, Yu Seob

    2016-01-01

    Introduction: We prospectively investigated the relationship between newborn male circumcision (NMC) and second to fourth digit ratio with penile length. Methods: As participants for our study, we identified already circumcised young patients who visited our hospital for urological treatment. The age at which the circumcision had been done was assessed. The patients’ height and weight were measured. Second to fourth digit ratio was calculated by measuring the second and fourth digit lengths. The flaccid and erectile penile lengths were measured from the base of the penis to the tip of the glans in standing position. Results: A total of 248 patients were included in our study. In univariate analysis, height, second to fourth digit ratio, flaccid penile length, and age of circumcision were associated with erectile penile length. Among these variables, second to fourth digit ratio, flaccid penile length, and age of circumcision were significant predictive factors for erectile penile length in multivariate analysis. The subjects were divided into two groups, including 72 patients in the NMC group and 176 patients in the non-NMC group. No significant difference was found in height, weight, and second to fourth digit ratio between both groups. However, flaccid (p<0.001) and erectile (p=0.001) penile lengths were shorter in the NMC group than in the non-NMC group. Conclusions: Despite the small number of subjects, this study shows that NMC was associated with shorter penile length. Second to fourth digit ratio, flaccid penile length, and age of circumcision were also significant predictive factors for erectile penile length. Further multicentre studies with larger number of subjects and biochemical analyses are needed for potential clinical applicability. PMID:27695583

  11. Fourth Generation Leptons and Muon $g-2$

    CERN Document Server

    Hou, Wei-Shu; Ma, Chien-Yi

    2008-01-01

    We consider the contributions to $g_\\mu-2$ from fourth generation neutral and charged leptons, $N$ and $E$, at the one-loop level. Diagramatically, there are two types of contributions: boson-boson-$N$, and $E$-$E$-boson in the loop diagram. In general, the effect from $N$ is suppressed by off-diagonal PMNS matrix element $V_{N\\mu}$, from the Standard Model to the Two-Higgs Doublet Models. With contribution from $E$, we consider flavor changing neutral couplings.

  12. Geometry, relativity and the fourth dimension

    CERN Document Server

    Rucker, Rudolf

    1977-01-01

    This is a highly readable, popular exposition of the fourth dimension and the structure of the universe. A remarkable pictorial discussion of the curved space-time we call home, it achieves even greater impact through the use of 141 excellent illustrations. This is the first sustained visual account of many important topics in relativity theory that up till now have only been treated separately.Finding a perfect analogy in the situation of the geometrical characters in Flatland, Professor Rucker continues the adventures of the two-dimensional world visited by a three-dimensional being to expl

  13. Fourth international seminar on horizontal steam generators

    Energy Technology Data Exchange (ETDEWEB)

    Tuomisto, H. [ed.] [IVO Group, Vantaa (Finland); Purhonen, H. [ed.] [VTT, Espoo (Finland); Kouhia, V. [ed.] [Lappeenranta Univ. of Technology (Finland)

    1997-12-31

    The general objective of the International Seminars of Horizontal Steam Generator Modelling has been the improvement in understanding of realistic thermal hydraulic behaviour of the generators when performing safety analyses for VVER reactors. The main topics presented in the fourth seminar were: thermal hydraulic experiments and analyses, primary collector integrity, feedwater distributor replacement, management of primary-to-secondary leakage accidents and new developments in the VVER safety technology. The number of participants, representing designers and manufacturers of the horizontal steam generators, plant operators, engineering companies, research organizations, universities and regulatory authorities, was 70 from 10 countries.

  14. Efficient Video Editing for Mobile Applications

    Directory of Open Access Journals (Sweden)

    Ignasi Vegas Pajaro

    2017-01-01

    Full Text Available Recording, storing and sharing video content has become one of the most popular usages of smartphones. This has resulted in demand for video editing apps that the users can use to edit their videos before sharing on various social networks. This study describes a technique to create a video editing application that uses the processing power of both GPU and CPU to process various editing tasks. The results and subsequent discussion shows that using the processing power of both the GPU and CPU in the video editing process makes the application much more time-efficient and responsive as compared to just the CPU-based processing.

  15. Distinct role of Arabidopsis mitochondrial P-type pentatricopeptide repeat protein-modulating editing protein, PPME, in nad1 RNA editing.

    Science.gov (United States)

    Leu, Kuan-Chieh; Hsieh, Ming-Hsiun; Wang, Huei-Jing; Hsieh, Hsu-Liang; Jauh, Guang-Yuh

    2016-06-02

    The mitochondrion is an important power generator in most eukaryotic cells. To preserve its function, many essential nuclear-encoded factors play specific roles in mitochondrial RNA metabolic processes, including RNA editing. RNA editing consists of post-transcriptional deamination, which alters specific nucleotides in transcripts to mediate gene expression. In plant cells, many pentatricopeptide repeat proteins (PPRs) participate in diverse organellar RNA metabolic processes, but only PLS-type PPRs are involved in RNA editing. Here, we report a P-type PPR protein from Arabidopsis thaliana, P-type PPR-Modulating Editing (PPME), which has a distinct role in mitochondrial nad1 RNA editing via RNA binding activity. In the homozygous ppme mutant, cytosine (C)-to-uracil (U) conversions at both the nad1-898 and 937 sites were abolished, disrupting Arg(300)-to-Trp(300) and Pro(313)-to-Ser(313) amino acid changes in the mitochondrial NAD1 protein. NAD1 is a critical component of mitochondrial respiration complex I; its activity is severely reduced in the homozygous ppme mutant, resulting in significantly altered growth and development. Both abolished RNA editing and defective complex I activity were completely rescued by CaMV 35S promoter- and PPME native promoter-driven PPME genomic fragments tagged with GFP in a homozygous ppme background. Our experimental results demonstrate a distinct role of a P-type PPR protein, PPME, in RNA editing in plant organelles.

  16. European Code against Cancer 4th Edition: Infections and Cancer.

    Science.gov (United States)

    Villain, Patricia; Gonzalez, Paula; Almonte, Maribel; Franceschi, Silvia; Dillner, Joakim; Anttila, Ahti; Park, Jin Young; De Vuyst, Hugo; Herrero, Rolando

    2015-12-01

    Of the 2,635,000 new cancer cases (excluding non-melanoma skin cancers) occurring in the European Union (EU) in 2012, it is estimated that approximately 185,000 are related to infection with human papillomaviruses (HPVs), hepatitis B and C viruses (HBV and HCV), and Helicobacter pylori (H. pylori). Chronic infection with these agents can lead to cancers of the cervix uteri, liver, and stomach, respectively. Chronic infection with HCV can also lead to B-cell non-Hodgkin lymphoma. Human immunodeficiency virus (HIV) infection continues to be of major public health importance in several EU countries and increases cancer risk via HIV-induced immunosuppression. The fourth edition of the European Code Against Cancer presents recommendations on effective and safe preventive interventions in order to reduce the risk of infection-related cancers in EU citizens. Based on current available evidence, the fourth edition recommends that parents ensure the participation of their children in vaccination programs against HBV (for newborns) and HPV (for girls). In the 'Questions and Answers' (Q&As) section about vaccination and infections in the website for the European Code Against Cancer, individuals who are at risk of chronic HBV or HCV are advised to seek medical advice about testing and obtaining treatment when appropriate. Individuals most at risk of HIV are advised to consult their doctor or healthcare provider to access counselling and, if needed, testing and treatment without delay. Information about H. pylori testing and treatment is also provided as testing might currently be offered in some high-risk areas in Europe. The rationale and supporting evidence for the recommendations on vaccination in the European Code Against Cancer, and for the main recommendations on vaccination and infection in the Q&As, are explained in the present review. Copyright © 2015 International Agency for Research on Cancer. Published by Elsevier Ltd. All rights reserved.

  17. Common and Unique Factors Associated with DSM-IV-TR Internalizing Disorders in Children

    Science.gov (United States)

    Higa-McMillan, Charmaine K.; Smith, Rita L.; Chorpita, Bruce F.; Hayashi, Kentaro

    2008-01-01

    With the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association. "Diagnostic and statistical manual of mental disorders DSM-IV Fourth Edition-Text Revision". Author, Washington, DC. 2000) ahead, decisions will be made about the future of taxonomic conceptualizations. This study examined the…

  18. Common and Unique Factors Associated with DSM-IV-TR Internalizing Disorders in Children

    Science.gov (United States)

    Higa-McMillan, Charmaine K.; Smith, Rita L.; Chorpita, Bruce F.; Hayashi, Kentaro

    2008-01-01

    With the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association. "Diagnostic and statistical manual of mental disorders DSM-IV Fourth Edition-Text Revision". Author, Washington, DC. 2000) ahead, decisions will be made about the future of taxonomic conceptualizations. This study examined the…

  19. Environmental Radioactivity from Natural, Industrial and Military Sources. 4th Edition

    Energy Technology Data Exchange (ETDEWEB)

    Jones, Steve

    1998-09-01

    Merril Eisenbud's series of books on environmental radioactivity have long had a place on the bookshelves of those involved with the environmental aspects of radiation protection. They provide authoritative coverage of the subject including sources, transport mechanisms and effects. The first edition, published in 1963, was naturally mostly concerned with the effects of nuclear weapons testing in the atmosphere. The second edition, published in 1977, reflected the then expansive phase of nuclear power development worldwide and included an extensive treatment of the nuclear fuel cycle and its contributions to environmental radioactivity. In 1987 the third edition included coverage of the Three Mile Island accident and the Chernobyl accident against the background of cessation of new orders for nuclear plant in the United States. The fourth edition is a major revision with a lot of new material, and the welcome adoption of SI units throughout. The principal additions to the new edition are chapters on environmental surveillance, radiological assessment and dose reconstruction, and the remediation of contaminated sites; nothing has been lost from the extensive coverage of other topics in the third edition, whilst the text and bibliography have been revised and brought up to date. Earlier editions of the book have provided good summaries of accidents which have resulted in environmental contamination, and the updating here results in more extensive and up-to-date coverage of the Three Mile Island and Chernobyl accidents, including the more recent evidence of health effects from the latter, together with new sections on the Palomares nuclear weapons accident in Spain, the Mayak/Chelyabinsk complex in Russia, and the accidents involving lost gamma radiation sources in Juarez, Mexico and Goiania, Brazil. Both here and in the extensive coverage of contamination at the USDoE production sites the new edition reflects and benefits from the increased public availability

  20. Statistical Physics Approaches to RNA Editing

    Science.gov (United States)

    Bundschuh, Ralf

    2012-02-01

    The central dogma of molecular Biology states that DNA is transcribed base by base into RNA which is in turn translated into proteins. However, some organisms edit their RNA before translation by inserting, deleting, or substituting individual or short stretches of bases. In many instances the mechanisms by which an organism recognizes the positions at which to edit or by which it performs the actual editing are unknown. One model system that stands out by its very high rate of on average one out of 25 bases being edited are the Myxomycetes, a class of slime molds. In this talk we will show how the computational methods and concepts from statistical Physics can be used to analyze DNA and protein sequence data to predict editing sites in these slime molds and to guide experiments that identified previously unknown types of editing as well as the complete set of editing events in the slime mold Physarum polycephalum.

  1. Attitude of fourth year Doctor of Pharmacy students towards pharmacy profession and their career preferences

    Directory of Open Access Journals (Sweden)

    Salman Saad

    2012-01-01

    Conclusion: Fourth year students believed that pharmacy education and practice affect the health care system. Their favorite career areas were clinical pharmacy, industrial pharmacy, and hospital pharmacy. Personal interest was the most important factor involved in this selection. Most of them were interested in pharmacy-related research activities.

  2. Weak gravitational lensing by fourth order gravity black holes

    CERN Document Server

    Horváth, Zsolt; Hobill, David; Capozziello, Salvatore; De Laurentis, Mariafelicia

    2012-01-01

    We discuss weak lensing characteristics for black holes in a fourth order f(R) gravity theory, characterized by a gravitational strength parameter $\\sigma $ and a distance scale $r_{c}$. Above $r_{c}$ gravity is strengthened and as a consequence weak lensing features are modified compared to the Schwarzschild case. We find a critical impact parameter (depending upon $r_{c}$) for which the behavior of the deflection angle changes. Using the Virbhadra-Ellis lens equation we improve the computation of the image positions, Einstein ring radii, magnification factors and the magnification ratio. We demonstrate that the magnification ratio as function of image separation has a different power-law dependence for each parameter $\\sigma $. As these are the lensing quantities most conveniently determined by direct measurements, future lensing surveys will be able to constrain the parameter $\\sigma $ based on this prediction.

  3. Cosmic Acceleration in a Model of Fourth Order Gravity

    CERN Document Server

    Banerjee, Shreya; Singh, Tejinder P

    2015-01-01

    We investigate a fourth order model of gravity, having a free length parameter, and no cosmological constant or dark energy. We consider cosmological evolution of a flat Friedmann universe in this model for the case that the length parameter is of the order of present Hubble radius. By making a suitable choice for the present value of the Hubble parameter, and value of third derivative of the scale factor (the jerk) we find that the model can explain cosmic acceleration to the same degree of accuracy as the standard concordance model. If the free length parameter is assumed to be time-dependent, and of the order of the Hubble parameter of the corresponding epoch, the model can still explain cosmic acceleration, and provides a possible resolution of the cosmic coincidence problem. We also compare redshift drift in this model, with that in the standard model.

  4. The Readiness of the European Union to Embrace the Fourth Industrial Revolution

    Directory of Open Access Journals (Sweden)

    Eva Kuruczleki

    2016-12-01

    Full Text Available Knowledge has become a crucial factor of production in the developed economies and, as humans are the carriers and utilisers of knowledge, skilled human resource is gaining similarly large relevance. These advancements are elements of the substantial changes that characterise the fourth industrial revolution – a phenomenon worth studying in detail. The European Union has been explicitly concerned about the shift to the knowledge economy since the Lisbon Summit of 2000. More than one and a half decades later the eu’s readiness to embrace the knowledge-driven fourth industrial revolution can be examined. We undertake that by creating an index based on various related data.

  5. Comparison of insertional RNA editing in Myxomycetes.

    Directory of Open Access Journals (Sweden)

    Cai Chen

    Full Text Available RNA editing describes the process in which individual or short stretches of nucleotides in a messenger or structural RNA are inserted, deleted, or substituted. A high level of RNA editing has been observed in the mitochondrial genome of Physarum polycephalum. The most frequent editing type in Physarum is the insertion of individual Cs. RNA editing is extremely accurate in Physarum; however, little is known about its mechanism. Here, we demonstrate how analyzing two organisms from the Myxomycetes, namely Physarum polycephalum and Didymium iridis, allows us to test hypotheses about the editing mechanism that can not be tested from a single organism alone. First, we show that using the recently determined full transcriptome information of Physarum dramatically improves the accuracy of computational editing site prediction in Didymium. We use this approach to predict genes in the mitochondrial genome of Didymium and identify six new edited genes as well as one new gene that appears unedited. Next we investigate sequence conservation in the vicinity of editing sites between the two organisms in order to identify sites that harbor the information for the location of editing sites based on increased conservation. Our results imply that the information contained within only nine or ten nucleotides on either side of the editing site (a distance previously suggested through experiments is not enough to locate the editing sites. Finally, we show that the codon position bias in C insertional RNA editing of these two organisms is correlated with the selection pressure on the respective genes thereby directly testing an evolutionary theory on the origin of this codon bias. Beyond revealing interesting properties of insertional RNA editing in Myxomycetes, our work suggests possible approaches to be used when finding sequence motifs for any biological process fails.

  6. Comparison of Insertional RNA Editing in Myxomycetes

    Science.gov (United States)

    Chen, Cai; Frankhouser, David; Bundschuh, Ralf

    2012-01-01

    RNA editing describes the process in which individual or short stretches of nucleotides in a messenger or structural RNA are inserted, deleted, or substituted. A high level of RNA editing has been observed in the mitochondrial genome of Physarum polycephalum. The most frequent editing type in Physarum is the insertion of individual Cs. RNA editing is extremely accurate in Physarum; however, little is known about its mechanism. Here, we demonstrate how analyzing two organisms from the Myxomycetes, namely Physarum polycephalum and Didymium iridis, allows us to test hypotheses about the editing mechanism that can not be tested from a single organism alone. First, we show that using the recently determined full transcriptome information of Physarum dramatically improves the accuracy of computational editing site prediction in Didymium. We use this approach to predict genes in the mitochondrial genome of Didymium and identify six new edited genes as well as one new gene that appears unedited. Next we investigate sequence conservation in the vicinity of editing sites between the two organisms in order to identify sites that harbor the information for the location of editing sites based on increased conservation. Our results imply that the information contained within only nine or ten nucleotides on either side of the editing site (a distance previously suggested through experiments) is not enough to locate the editing sites. Finally, we show that the codon position bias in C insertional RNA editing of these two organisms is correlated with the selection pressure on the respective genes thereby directly testing an evolutionary theory on the origin of this codon bias. Beyond revealing interesting properties of insertional RNA editing in Myxomycetes, our work suggests possible approaches to be used when finding sequence motifs for any biological process fails. PMID:22383871

  7. Comparison of insertional RNA editing in Myxomycetes.

    Science.gov (United States)

    Chen, Cai; Frankhouser, David; Bundschuh, Ralf

    2012-01-01

    RNA editing describes the process in which individual or short stretches of nucleotides in a messenger or structural RNA are inserted, deleted, or substituted. A high level of RNA editing has been observed in the mitochondrial genome of Physarum polycephalum. The most frequent editing type in Physarum is the insertion of individual Cs. RNA editing is extremely accurate in Physarum; however, little is known about its mechanism. Here, we demonstrate how analyzing two organisms from the Myxomycetes, namely Physarum polycephalum and Didymium iridis, allows us to test hypotheses about the editing mechanism that can not be tested from a single organism alone. First, we show that using the recently determined full transcriptome information of Physarum dramatically improves the accuracy of computational editing site prediction in Didymium. We use this approach to predict genes in the mitochondrial genome of Didymium and identify six new edited genes as well as one new gene that appears unedited. Next we investigate sequence conservation in the vicinity of editing sites between the two organisms in order to identify sites that harbor the information for the location of editing sites based on increased conservation. Our results imply that the information contained within only nine or ten nucleotides on either side of the editing site (a distance previously suggested through experiments) is not enough to locate the editing sites. Finally, we show that the codon position bias in C insertional RNA editing of these two organisms is correlated with the selection pressure on the respective genes thereby directly testing an evolutionary theory on the origin of this codon bias. Beyond revealing interesting properties of insertional RNA editing in Myxomycetes, our work suggests possible approaches to be used when finding sequence motifs for any biological process fails.

  8. Strategic Leadership Primer (Third Edition)

    Science.gov (United States)

    2010-01-01

    Meinhart, while also acknowledging previous edition contributions from Dr� Lenny Wong, Dr� Craig Bullis , and Colonel (Ret) George Reed� 1 CHAPTER 1...the cyber war� Although the strategies are different between commercial and government entities, at the end of the day both seek competitive...and everyone else—to 140 characters per tweet, and he tweets once or more almost daily�4 400 million people have established accounts on Facebook �5

  9. Electromagnetic Fields, 2nd Edition

    Science.gov (United States)

    Wangsness, Roald K.

    1986-07-01

    This revised edition provides patient guidance in its clear and organized presentation of problems. It is rich in variety, large in number and provides very careful treatment of relativity. One outstanding feature is the inclusion of simple, standard examples demonstrated in different methods that will allow students to enhance and understand their calculating abilities. There are over 145 worked examples; virtually all of the standard problems are included.

  10. Fourth Thematic CERN School of Computing

    CERN Multimedia

    Alberto Pace, CSC Director

    2016-01-01

    The Fourth Thematic School of Computing (tCSC2016) takes place this year in Split, Croatia, from 22 to 28 May 2016.   The theme is "Efficient and Parallel Processing of Scientific Data", looking at: The challenge of scientific data processing: commonalities, analogies and the main differences between different sciences. Size of scientific software projects. Parallelism and asynchronism: computation and I/O. The School is open to postgraduate students and research workers with a few years' experience in elementary particle physics, computing, engineering or related fields.  All applicants are welcome, including former and future participants in the main CSC summer school. Registration will close on 15 February and participation is limited to 24 students. To register, please go here. About: The Thematic Schools are part of the annual series of CERN Schools of Computing, to promote advanced learning and knowledge exchange on the subject of scientific compu...

  11. Fourth International Conference on Complex Systems

    CERN Document Server

    Minai, Ali A; Unifying Themes in Complex Systems IV

    2008-01-01

    In June of 2002, over 500 professors, students and researchers met in Boston, Massachusetts for the Fourth International Conference on Complex Systems. The attendees represented a remarkably diverse collection of fields: biology, ecology, physics, engineering, computer science, economics, psychology and sociology, The goal of the conference was to encourage cross-fertilization between the many disciplines represented and to deepen understanding of the properties common to all complex systems. This volume contains 43 papers selected from the more than 200 presented at the conference. Topics include: cellular automata, neurology, evolution, computer science, network dynamics, and urban planning. About NECSI: For over 10 years, The New England Complex Systems Institute (NECSI) has been instrumental in the development of complex systems science and its applications. NECSI conducts research, education, knowledge dissemination, and community development around the world for the promotion of the study of complex sys...

  12. Fourth-generation Mars vehicle concepts

    Science.gov (United States)

    Sherwood, Brent

    1994-09-01

    Conceptual designs for fourth-generation crew-carrying Mars transfer and excursion vehicles, fully integrated to state-of-the-art standards, are presented. The resulting vehicle concepts are sized for six crew members, and can support all opposition and conjunction opportunities in or after 2014. The modular, reusable transfer ship is launched to Earth orbit on six 185-ton-class boosters and assembled there robotically. Its dual nuclear-thermal rocket engines use liquid hydrogen propollant. The payload consists of a microgravity habitation system and an expendable lift-to-drag = 1.6 lander capable of aeromaneuvering to sites within +/- 20 deg of the equator. This lander can deliver either an expendable, storable-bipropellant crew-carrying ascent vehicle, or 40 tons of cargo, and it is capable of limited surface mobility to support base buildup. Multiple cargo landers sent ahead on robotic transfer vehicles deliver the supplies and equipment required for long-duration surface missions.

  13. Fourth ventricle meningiomas: a rare entity.

    Science.gov (United States)

    Pichierri, Angelo; Ruggeri, Andrea; Morselli, Carlotta; Delfini, Roberto

    2011-08-01

    Fourth ventricle meningiomas (FVMs) are rare, often misdiagnosed, lesions. To the best of our knowledge, 47 cases have been reported in the literature: we describe our series of three cases treated at our Institution, focusing on some diagnostic tips and intraoperative features of these tumours. Our three patients have a history of headache. Gait disturbances, vomiting and/or diplopia complicated the clinical picture before the referral at our Department. The operations were uneventful, and the patients fully recovered from neurological symptoms. They are free of recurrence at a median follow-up of 19 years. FVMs are rare lesions, which are difficult to differentiate preoperatively from the much more common ependymomas. A preoperative distinction would be extremely advantageous: indeed, although both tumours share similar radiological and clinical patterns, they clearly differ as to surgical difficulty and outcome. In fact, meningiomas are comparatively easier to remove, granting better clinical results.

  14. Fourth World Theory: The Evolution of . . .

    Directory of Open Access Journals (Sweden)

    Olon F. Dotson

    2014-05-01

    Full Text Available Fourth World theory is a methodology for examining and developing greater understanding of the extent of the distress and abandonment commonly found in the cores of American cities resulting from de-industrialization, historic segregation and discrimination patterns, suburban sprawl, erosion of a viable tax base, racism, inability to embrace the concept of desegregation and civil rights legislation, fear, despair, crumbling infrastructure systems, disinvestment in urban school systems, and environmental justice issues. This article uses the analytical lens of Fourth World theory to examine how such structural and cultural forces contributed to the severely distressed conditions now found in the city of Gary, Indiana. Tracking its one-hundred-year history, from its founding as an industrial town through its post-industrial decline occurring during the city’s first African-American mayor’s five terms in office, the methodology clearly demonstrates how the social construction of race has systematically undermined every aspect of Gary’s overall quality of life. To illustrate that this city is not an anomaly but rather reflects a typical pattern of disparity and uneven development arising from racist practices, Gary is compared to other cities of similar size and also to the much larger Detroit. The article triangulates academic literature, news media archives, and an oral history provided by the mayor to show how Gary evolved from being a model industrial city to a cauldron of racial disparity. The paper concludes by arguing that continued absence of reflection on the nation’s historical racialization of place threatens not just impoverished communities of color, but also the sustainability of the entire nation.

  15. Editing as a psychological practice.

    Science.gov (United States)

    Beebe, John

    2006-06-01

    The experience of the Jungian analyst in the role of editor of manuscripts by creative colleagues is examined. Historical precedents include Michael Fordham's editorial correspondence with Jung around the latter's synchronicity essay; Jung's handling of manuscripts submitted by Sabina Spielrein to the Jahrbuch für psychoanalytische und psychopathologische Forschungen and various authors to the Zentralblatt für Psychotherapie und ihre Grenzgebiete, and the author's close editing of a paper submitted by Andrew Samuels to the Journal of Analytical Psychology. In addition to mustering an adequate amount of generosity, erudition, and availability, the analytic editor must know how to clarify a psychological argument and to gauge the psychological impact of the written text. Notwithstanding transference/countertransference phenomena that can emerge around issues of competition, envy, and territoriality when author and editor are also fellow-authors working in the same field, the editor needs to be comfortable about serving as the author's selfobject and midwife. From an analytic perspective, although communicating decisions about the best way to put ideas into words can sometimes attract transference to the editor, the more profound transference that analysts experience in the editing situation is toward the text being edited, which helps to motivate donated time spent caring for journal manuscripts.

  16. RNA Editing in Plant Mitochondria

    Science.gov (United States)

    Hiesel, Rudolf; Wissinger, Bernd; Schuster, Wolfgang; Brennicke, Axel

    1989-12-01

    Comparative sequence analysis of genomic and complementary DNA clones from several mitochondrial genes in the higher plant Oenothera revealed nucleotide sequence divergences between the genomic and the messenger RNA-derived sequences. These sequence alterations could be most easily explained by specific post-transcriptional nucleotide modifications. Most of the nucleotide exchanges in coding regions lead to altered codons in the mRNA that specify amino acids better conserved in evolution than those encoded by the genomic DNA. Several instances show that the genomic arginine codon CGG is edited in the mRNA to the tryptophan codon TGG in amino acid positions that are highly conserved as tryptophan in the homologous proteins of other species. This editing suggests that the standard genetic code is used in plant mitochondria and resolves the frequent coincidence of CGG codons and tryptophan in different plant species. The apparently frequent and non-species-specific equivalency of CGG and TGG codons in particular suggests that RNA editing is a common feature of all higher plant mitochondria.

  17. Connectivity editing for quad-dominant meshes

    KAUST Repository

    Peng, Chihan

    2013-08-01

    We propose a connectivity editing framework for quad-dominant meshes. In our framework, the user can edit the mesh connectivity to control the location, type, and number of irregular vertices (with more or fewer than four neighbors) and irregular faces (non-quads). We provide a theoretical analysis of the problem, discuss what edits are possible and impossible, and describe how to implement an editing framework that realizes all possible editing operations. In the results, we show example edits and illustrate the advantages and disadvantages of different strategies for quad-dominant mesh design. © 2013 The Author(s) Computer Graphics Forum © 2013 The Eurographics Association and John Wiley & Sons Ltd.

  18. Searching for the fourth family quarks through anomalous decays

    Science.gov (United States)

    Sahin, M.; Sultansoy, S.; Turkoz, S.

    2010-09-01

    The flavor democracy hypothesis predicts the existence of the fourth standard model family. Because of the high masses of the fourth family quarks, their anomalous decays could be dominant if certain criteria are met. This will drastically change the search strategy at hadron colliders. We show that the fourth standard model family down quarks with masses up to 400-450 GeV can be observed (or excluded) via anomalous decays by Tevatron.

  19. The Fourth Gospel as a textual field of meaning

    OpenAIRE

    Micallef, Martin

    2014-01-01

    The Fourth Gospel is a textual field of meaning and it reinforces pressure on readers to differentiate appearance from intended meaning. No single interpretation can claim to have said the last word on the meaning of the Fourth Gospel’s use of language, which may be considered as the most striking characteristic of this Gospel. The whole network of the Johannine literary devices and vocabulary is an expression of the Fourth Gospel’s theological message and brings dissimilari...

  20. Operational Transformation In Co-Operative Editing

    Directory of Open Access Journals (Sweden)

    Mandeep Kaur

    2015-08-01

    Full Text Available Cooperative Editing Systems in real-time allows a virtual team to view and edit a shared document at the same time. The document shared must be synchronized in order to ensure consistency for all the participants. This paper describes the Operational Transformation the evolution of its techniques its various applications major issues and achievements. In addition this paper will present working of a platform where two users can edit a code programming file at the same time.

  1. Operational Transformation In Co-Operative Editing

    OpenAIRE

    Mandeep Kaur; Manpreet Singh; Harneet Kaur; Simran Kaur

    2015-01-01

    Cooperative Editing Systems in real-time allows a virtual team to view and edit a shared document at the same time. The document shared must be synchronized in order to ensure consistency for all the participants. This paper describes the Operational Transformation the evolution of its techniques its various applications major issues and achievements. In addition this paper will present working of a platform where two users can edit a code programming file at the same time.

  2. Review on Urban Sociology(2nd Edition)

    Institute of Scientific and Technical Information of China (English)

    Liu; Yuting; Li; Caige

    2016-01-01

    Urban Sociology(2nd Edition)Author:Gu Chaolin,Liu Jiayan,et al.Year:2013Publisher:Tsinghua University Press ISBN:9787302337591(446 pages,in Chinese)Urban Sociology is a textbook edited by Gu Chaolin,a wellk now n schola r of u rba n st udies i n Ch i na,a nd published by Tsinghua University Press in 2013.The first edition of this book,

  3. Deciphering the functions and regulation of brain-enriched A-to-I RNA editing.

    Science.gov (United States)

    Li, Jin Billy; Church, George M

    2013-11-01

    Adenosine-to-inosine (A-to-I) RNA editing, in which genomically encoded adenosine is changed to inosine in RNA, is catalyzed by adenosine deaminase acting on RNA (ADAR). This fine-tuning mechanism is critical during normal development and diseases, particularly in relation to brain functions. A-to-I RNA editing has also been hypothesized to be a driving force in human brain evolution. A large number of RNA editing sites have recently been identified, mostly as a result of the development of deep sequencing and bioinformatic analyses. Deciphering the functional consequences of RNA editing events is challenging, but emerging genome engineering approaches may expedite new discoveries. To understand how RNA editing is dynamically regulated, it is imperative to construct a spatiotemporal atlas at the species, tissue and cell levels. Future studies will need to identify the cis and trans regulatory factors that drive the selectivity and frequency of RNA editing. We anticipate that recent technological advancements will aid researchers in acquiring a much deeper understanding of the functions and regulation of RNA editing.

  4. The Fourth World Conference on Women.

    Science.gov (United States)

    1995-01-01

    The Fourth World Conference on Women held in Beijing during September 4-15, 1995, was a major success. The platform for action adopted by consensus at the conference is comprised of the mission statement, a global framework, critical areas of concern, strategic objectives and actions, and institutional and financial arrangements. The conference was an extension of other large international conferences organized under UN initiative over the past 15 years. The Beijing platform of action aims to remove all obstacles to women's active participation in all spheres of public and private life through a full and equal share in economic, social, cultural, and political decision-making. The following concerns were defined by the conference: eradicating poverty, increasing school enrollment and eliminating gender inequalities in access to education, improving access to health care and eliminating gender inequalities in access to services, eliminating violence against women, mitigating the consequences of armed conflicts against women, securing equal access of men and women to economic resources and employment, providing equal participation of men and women in power structures and decision making, enhancing national mechanisms to promote the advancement of women, protecting the rights of girls and women, eradicating stereotypes about women, participating in the management of natural resources and environmental protection, and improving the status of girls.

  5. Mandibular asymmetry and the fourth dimension.

    Science.gov (United States)

    Kaban, Leonard B

    2009-03-01

    This paper represents more than 30 years of discussion and collaboration with Drs Joseph Murray and John Mulliken in an attempt to understand growth patterns over time (ie, fourth dimension) in patients with hemifacial microsomia (HFM). This is essential for the development of rational treatment protocols for children and adults with jaw asymmetry. Traditionally, HFM was thought of as a unilateral deformity, but it was recognized that 20% to 30% of patients had bilateral abnormalities. However, early descriptions of skeletal correction addressed almost exclusively lengthening of the short (affected) side of the face. Based on longitudinal clinical observations of unoperated HFM patients, we hypothesized that abnormal mandibular growth is the earliest skeletal manifestation and that restricted growth of the mandible plays a pivotal role in progressive distortion of both the ipsilateral and contralateral facial skeleton. This hypothesis explains the progressive nature of the asymmetry in patients with HFM and provides the rationale for surgical lengthening of the mandible in children to prevent end-stage deformity. During the past 30 years, we have learned that this phenomenon of progressive distortion of the adjacent and contralateral facial skeleton occurs with other asymmetric mandibular undergrowth (tumor resection, radiation therapy, or posttraumatic defects) and overgrowth (mandibular condylar hyperplasia) conditions. In this paper, I describe the progression of deformity with time in patients with mandibular asymmetry as a result of undergrowth and overgrowth. Understanding these concepts is critical for the development of rational treatment protocols for adults with end-stage asymmetry and for children to minimize secondary deformity.

  6. Neural crest: The fourth germ layer

    Directory of Open Access Journals (Sweden)

    K Shyamala

    2015-01-01

    Full Text Available The neural crest cells (NCCs, a transient group of cells that emerges from the dorsal aspect of the neural tube during early vertebrate development has been a fascinating group of cells because of its multipotency, long range migration through embryo and its capacity to generate a prodigious number of differentiated cell types. For these reasons, although derived from the ectoderm, the neural crest (NC has been called the fourth germ layer. The non neural ectoderm, the neural plate and the underlying mesoderm are needed for the induction and formation of NC cells. Once formed, NC cells start migrating as a wave of cells, moving away from the neuroepithelium and quickly splitting into distinct streams. These migrating NCCs home in to different regions and give rise to plethora of tissues. Umpteen number of signaling molecules are essential for formation, epithelial mesenchymal transition, delamination, migration and localization of NCC. Authors believe that a clear understanding of steps and signals involved in NC formation, migration, etc., may help in understanding the pathogenesis behind cancer metastasis and many other diseases. Hence, we have taken this review to discuss the various aspects of the NC cells.

  7. TALE: a tale of genome editing.

    Science.gov (United States)

    Zhang, Mingjie; Wang, Feng; Li, Shifei; Wang, Yan; Bai, Yun; Xu, Xueqing

    2014-01-01

    Transcription activator-like effectors (TALEs), first identified in Xanthomonas bacteria, are naturally occurring or artificially designed proteins that modulate gene transcription. These proteins recognize and bind DNA sequences based on a variable numbers of tandem repeats. Each repeat is comprised of a set of ∼ 34 conserved amino acids; within this conserved domain, there are usually two amino acids that distinguish one TALE from another. Interestingly, TALEs have revealed a simple cipher for the one-to-one recognition of proteins for DNA bases. Synthetic TALEs have been used to successfully target genes in a variety of species, including humans. Depending on the type of functional domain that is fused to the TALE of interest, these proteins can have diverse biological effects. For example, after binding DNA, TALEs fused to transcriptional activation domains can function as robust transcription factors (TALE-TFs), while fused to restriction endonucleases (TALENs) can cut DNA. Targeted genome editing, in theory, is capable of modifying any endogenous gene sequence of interest; this can be performed in cells or organisms, and may be applied to clinical gene-based therapies in the future. With current technologies, highly accurate, specific, and reliable gene editing cannot be achieved. Thus, recognition and binding mechanisms governing TALE biology are currently hot research areas. In this review, we summarize the major advances in TALE technology over the past several years with a focus on the interaction between TALEs and DNA, TALE design and construction, potential applications for this technology, and unique characteristics that make TALEs superior to zinc finger endonucleases.

  8. GPU Computing Gems Emerald Edition

    CERN Document Server

    Hwu, Wen-mei W

    2011-01-01

    ".the perfect companion to Programming Massively Parallel Processors by Hwu & Kirk." -Nicolas Pinto, Research Scientist at Harvard & MIT, NVIDIA Fellow 2009-2010 Graphics processing units (GPUs) can do much more than render graphics. Scientists and researchers increasingly look to GPUs to improve the efficiency and performance of computationally-intensive experiments across a range of disciplines. GPU Computing Gems: Emerald Edition brings their techniques to you, showcasing GPU-based solutions including: Black hole simulations with CUDA GPU-accelerated computation and interactive display of

  9. APP Snrinn Edition Kicks Off

    Institute of Scientific and Technical Information of China (English)

    Tang Rong

    2012-01-01

    When European textile insiders still take delight in talking about the last apparel sourcing show in September 2011, the debut of APP Spring edition bring people back to the Le Bourget Expo Center, with entire passion. The 7th APP Show, sponsored by China National Textile and Apparel Council (CNTAC), organized by the Sub-Council of Textile Industry, China Council for the Promotion of International Trade (CCPIT TEX), China National Garment Association and Messe Frankfurt French Subsidiary, was on display from Feb 13th to 16th 2012,

  10. Biocommunication and natural genome editing

    Institute of Scientific and Technical Information of China (English)

    Guenther; Witzany

    2010-01-01

    The biocommunicative approach investigates communication processes within and among cells,tissues,organs and organisms as sign-mediated interactions,and nucleotide sequences as code,i.e.language-like text,which follows in parallel three kinds of rules:combinatorial (syntactic),context-sensitive(pragmatic),and contentspecific(semantic).Natural genome editing from a bio-communicative perspective is competent agent-driven generation and integration of meaningful nucleotide sequences into pre-existing genomic content arrangements and the ability to(re-)combine and(re-)regulate them according to context-dependent(i.e.adaptational) purposes of the host organism.

  11. RNA Editing and Its Molecular Mechanism in Plant Organelles

    OpenAIRE

    2016-01-01

    RNA editing by cytidine (C) to uridine (U) conversions is widespread in plant mitochondria and chloroplasts. In some plant taxa, “reverse” U-to-C editing also occurs. However, to date, no instance of RNA editing has yet been reported in green algae and the complex thalloid liverworts. RNA editing may have evolved in early land plants 450 million years ago. However, in some plant species, including the liverwort, Marchantia polymorpha, editing may have been lost during evolution. Most RNA edit...

  12. Field-Based Concerns about Fourth-Generation Evaluation Theory.

    Science.gov (United States)

    Lai, Morris K.

    Some aspects of fourth generation evaluation procedures that have been advocated by E. G. Guba and Y. S. Lincoln were examined empirically, with emphasis on areas where there have been discrepancies between theory and field-based experience. In fourth generation evaluation, the product of an evaluation is not a set of conclusions, recommendations,…

  13. Genetic Architectures of Quantitative Variation in RNA Editing Pathways.

    Science.gov (United States)

    Gu, Tongjun; Gatti, Daniel M; Srivastava, Anuj; Snyder, Elizabeth M; Raghupathy, Narayanan; Simecek, Petr; Svenson, Karen L; Dotu, Ivan; Chuang, Jeffrey H; Keller, Mark P; Attie, Alan D; Braun, Robert E; Churchill, Gary A

    2016-02-01

    RNA editing refers to post-transcriptional processes that alter the base sequence of RNA. Recently, hundreds of new RNA editing targets have been reported. However, the mechanisms that determine the specificity and degree of editing are not well understood. We examined quantitative variation of site-specific editing in a genetically diverse multiparent population, Diversity Outbred mice, and mapped polymorphic loci that alter editing ratios globally for C-to-U editing and at specific sites for A-to-I editing. An allelic series in the C-to-U editing enzyme Apobec1 influences the editing efficiency of Apob and 58 additional C-to-U editing targets. We identified 49 A-to-I editing sites with polymorphisms in the edited transcript that alter editing efficiency. In contrast to the shared genetic control of C-to-U editing, most of the variable A-to-I editing sites were determined by local nucleotide polymorphisms in proximity to the editing site in the RNA secondary structure. Our results indicate that RNA editing is a quantitative trait subject to genetic variation and that evolutionary constraints have given rise to distinct genetic architectures in the two canonical types of RNA editing.

  14. A New Perspective on Peer Editing.

    Science.gov (United States)

    Amores, Maria J.

    1997-01-01

    Describes the peer-editing behaviors of eight undergraduate students in a third-year Spanish composition and grammar review course. Data collected over four months through interviews, participant observation, artifact inventories, and questionnaires revealed a strong tendency among informants to define the peer-editing process in social and…

  15. Bibliography of Fynbos ecology: 2nd edition

    CSIR Research Space (South Africa)

    Manders, PT

    1989-12-01

    Full Text Available The first edition of a bibliography of fynbos ecology was produced in 1981 and comprised 814 references to work completed or commenced prior to the initiation of the Fynbos Biome Project. It is appropriate that this second edition...

  16. Editing Technical Proposals (The Friendly Editor).

    Science.gov (United States)

    Bush, Don

    1994-01-01

    Makes suggestions for editing technical proposals. Discusses the marketeers, the hierarchy of hype, how to save days, managing story boards, expediting a laborious process, teaching engineers to write, writing incrementally, the art group, and the editing task. Argues that the best proposals come from starting to write early. (SR)

  17. Books in Action: The Armed Services Editions.

    Science.gov (United States)

    Cole, John Y., Ed.

    In an effort to reach a wide audience, the Center for the Book in the Library of Congress presents this book in honor of the 40th anniversary celebration of the Armed Services Editions (ASE), the paperback books distributed during World War II. The titles of the essays and their authors are as follows: "The Armed Services Editions: An…

  18. Tax Justice Focus – The Whistleblower edition

    OpenAIRE

    Young, M A; Tax Justice Network

    2015-01-01

    Guest edited by Mary Alice Young of the University of the West of England, this edition is both an exploration of the difficulties confronting people who want to blow the whistle on companies engaged in providing financial services, and an acknowledgment of their personal courage.

  19. Applications of genome editing in insects

    Science.gov (United States)

    Insect genome editing was first reported 1991 in Drosophila melanogaster but the technology used was not portable to other species. Not until the recent development of facile, engineered DNA endonuclease systems has gene editing become widely available to insect scientists. Most applications in inse...

  20. Caution required for handling genome editing technology.

    Science.gov (United States)

    Araki, Motoko; Nojima, Kumie; Ishii, Tetsuya

    2014-05-01

    Genome-editing technology, although a robust tool for genetic engineering, is creating indistinct regulatory boundaries between naturally occurring and modified organisms. However, researchers must act with caution in research and development to avoid misleading society. Furthermore, appropriate regulations should be proactively discussed and established for handling genome-editing technology.

  1. Accounting for Independent Schools. Second Edition.

    Science.gov (United States)

    National Association of Independent Schools, Boston, MA.

    This is a thoroughly revised edition of the 1969 publication, "Accounting for Independent Schools," a guide that attempted to codify basic accounting principles and practices for specific application to independent schools. The focus of the second edition is more on refining practices than on initiating them, and more on extending the managerial…

  2. Accounting for Independent Schools. Second Edition.

    Science.gov (United States)

    National Association of Independent Schools, Boston, MA.

    This is a thoroughly revised edition of the 1969 publication, "Accounting for Independent Schools," a guide that attempted to codify basic accounting principles and practices for specific application to independent schools. The focus of the second edition is more on refining practices than on initiating them, and more on extending the managerial…

  3. CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants

    DEFF Research Database (Denmark)

    Spisák, Sándor; Lawrenson, Kate; Fu, Yanfang

    2015-01-01

    a general pipeline in which candidate functional SNPs are first evaluated by fine mapping, epigenomic profiling, and epigenome editing, and then interrogated for causal function by using genome editing to create isogenic cell lines followed by phenotypic characterization. To validate this approach, we...... analyzed the 6q22.1 prostate cancer risk locus and identified rs339331 as the top-scoring SNP. Epigenome editing confirmed that the rs339331 region possessed regulatory potential. By using transcription activator-like effector nuclease (TALEN)-mediated genome editing, we created a panel of isogenic 22Rv1...... prostate cancer cell lines representing all three genotypes (TT, TC, CC) at rs339331. Introduction of the 'T' risk allele increased transcription of the regulatory factor 6 (RFX6) gene, increased homeobox B13 (HOXB13) binding at the rs339331 region, and increased deposition of the enhancer-associated H3K4...

  4. Exploring the RNA editing potential of RNA-Seq data by ExpEdit.

    Science.gov (United States)

    D'Antonio, Mattia; Picardi, Ernesto; Castrignanò, Tiziana; D'Erchia, Anna Maria; Pesole, Graziano

    2015-01-01

    Revealing the impact of A-to-I RNA editing in RNA-Seq experiments is relevant in humans because RNA editing can influence gene expression. In addition, its deregulation has been linked to a variety of human diseases. Exploiting the RNA editing potential in complete RNA-Seq datasets, however, is a challenging task. Indeed, no dedicated software is available, and sometimes deep computational skills and appropriate hardware resources are required. To explore the impact of known RNA editing events in massive transcriptome sequencing experiments, we developed the ExpEdit web service application. In the present work, we provide an overview of ExpEdit as well as methodologies to investigate known RNA editing in human RNA-Seq datasets.

  5. An isolated fourth ventricle in neurosarcoidosis: MRI findings

    Energy Technology Data Exchange (ETDEWEB)

    Hesselmann, Volker; Terstegge, Klaus; Schulte, Oliver; Krug, Barbara; Lackner, Klaus [Department of Radiology, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne (Germany); Wedekind, Christoph [Department of Neurosurgery, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne (Germany); Voges, Juergen [Department of Stereotaxy und Functional Neurosurgery, University of Cologne, Joseph Stelzmann Strasse 9, 50924 Cologne (Germany)

    2002-07-01

    We report on an isolated enlargement of the fourth ventricle in a patient with neurosarcoidosis which developed 3 years after the insertion of a ventriculo-atrial shunt. Repeated MRI images were obtained in a patient with known neurosarcoidosis between 1995 and 2000. Imaging findings were correlated to the medical course of the patient, who developed a hydrocephalus and a trapped fourth ventricle consecutively. The isolation was presumably due to granulomatous inflammation of the ependyma surrounding the fourth ventricular outlets. The isolated fourth ventricle was responsible for a deterioration of neurological status. Neurosarcoidosis is a severe complication in sarcoidosis patients. An isolated enlargement of the fourth ventricle is a rare complication in clinically deteriorated patients with neurosarcoidosis and ventricular drainage, which may require neurosurgical treatment. (orig.)

  6. Syringomyelia regression after shunting of a trapped fourth ventricle

    Directory of Open Access Journals (Sweden)

    Dukagjin Morina

    2013-01-01

    Full Text Available We describe a case of progressive syringomyelia following post-infectious trapped fourth ventricle (TFV, which resolved after shunting of the fourth ventricle. A 28-year-old female who had previously undergone treatment of intracerebral hemorrhage and meningitis developed a hydrocephalus with TFV. After 3 years she developed disturbance of walking and coordination. Cranial-CT revealed an enlargement of the shunted fourth ventricle as a result of shunt dysfunction. Furthermore a cervical syringomyelia developed. The patient underwent a revision of a failed fourth ventriculo- peritoneal shunt. Postoperatively, syringomyelia resolved within 6 months and the associated neurological deficits improved significantly. An insufficiency of cerebrospinal fluid draining among patients with TFV can be associated with communicating syringomyelia. An early detection and treatment seems important on resolving syringomyelia and avoiding permanent neurological deficits. Ventriculo-peritoneal shunt in trapped fourth ventricles can resolve a secondary syringomyelia.

  7. Proceedings: Fourth Workshop on Mining Scientific Datasets

    Energy Technology Data Exchange (ETDEWEB)

    Kamath, C

    2001-07-24

    Commercial applications of data mining in areas such as e-commerce, market-basket analysis, text-mining, and web-mining have taken on a central focus in the JCDD community. However, there is a significant amount of innovative data mining work taking place in the context of scientific and engineering applications that is not well represented in the mainstream KDD conferences. For example, scientific data mining techniques are being developed and applied to diverse fields such as remote sensing, physics, chemistry, biology, astronomy, structural mechanics, computational fluid dynamics etc. In these areas, data mining frequently complements and enhances existing analysis methods based on statistics, exploratory data analysis, and domain-specific approaches. On the surface, it may appear that data from one scientific field, say genomics, is very different from another field, such as physics. However, despite their diversity, there is much that is common across the mining of scientific and engineering data. For example, techniques used to identify objects in images are very similar, regardless of whether the images came from a remote sensing application, a physics experiment, an astronomy observation, or a medical study. Further, with data mining being applied to new types of data, such as mesh data from scientific simulations, there is the opportunity to apply and extend data mining to new scientific domains. This one-day workshop brings together data miners analyzing science data and scientists from diverse fields to share their experiences, learn how techniques developed in one field can be applied in another, and better understand some of the newer techniques being developed in the KDD community. This is the fourth workshop on the topic of Mining Scientific Data sets; for information on earlier workshops, see http://www.ahpcrc.org/conferences/. This workshop continues the tradition of addressing challenging problems in a field where the diversity of applications is

  8. An Organelle RNA Recognition Motif Protein Is Required for Photosystem II Subunit psbF Transcript Editing1[OPEN

    Science.gov (United States)

    Lucas, Meriah K.

    2017-01-01

    Loss-of-function mutations in ORGANELLE RNA RECOGNITION MOTIF PROTEIN6 (ORRM6) result in the near absence of RNA editing of psbF-C77 and the reduction in accD-C794 editing in Arabidopsis (Arabidopsis thaliana). The orrm6 mutants have decreased levels of photosystem II (PSII) proteins, especially PsbF, lower PSII activity, pale green pigmentation, smaller leaf and plant sizes, and retarded growth. Stable expression of ORRM6 rescues the orrm6 editing defects and mutant phenotype. Unlike ORRM1, the other known ORRM plastid editing factor, ORRM6, does not contain RNA editing interacting protein/multiple organellar RNA editing factor (RIP/MORF) boxes, which are required for ORRM1 to interact with site-specific pentatricopeptide repeat protein editing factors. ORRM6 interacts with RIP1/MORF8, RIP2/MORF2, and RIP9/MORF9, known components of RNA editosomes. While some plastid RRM proteins are involved in other forms of RNA processing and translation, the primary function of ORRM6 is evidently to mediate psbF-C77 editing, like the essential site-specific pentatricopeptide repeat protein LOW PSII ACCUMULATION66. Stable expression in the orrm6 mutants of a nucleus-encoded, plastid-targeted PsbF protein from a psbF gene carrying a T at nucleotide 77 significantly increases leaf and plant sizes, chlorophyll content, and PSII activity. These transformants demonstrate that plastid RNA editing can be bypassed through the expression of nucleus-encoded, edited forms of plastid genes. PMID:28213559

  9. An Organelle RNA Recognition Motif Protein Is Required for Photosystem II Subunit psbF Transcript Editing.

    Science.gov (United States)

    Hackett, Justin B; Shi, Xiaowen; Kobylarz, Amy T; Lucas, Meriah K; Wessendorf, Ryan L; Hines, Kevin M; Bentolila, Stephane; Hanson, Maureen R; Lu, Yan

    2017-04-01

    Loss-of-function mutations in ORGANELLE RNA RECOGNITION MOTIF PROTEIN6 (ORRM6) result in the near absence of RNA editing of psbF-C77 and the reduction in accD-C794 editing in Arabidopsis (Arabidopsis thaliana). The orrm6 mutants have decreased levels of photosystem II (PSII) proteins, especially PsbF, lower PSII activity, pale green pigmentation, smaller leaf and plant sizes, and retarded growth. Stable expression of ORRM6 rescues the orrm6 editing defects and mutant phenotype. Unlike ORRM1, the other known ORRM plastid editing factor, ORRM6, does not contain RNA editing interacting protein/multiple organellar RNA editing factor (RIP/MORF) boxes, which are required for ORRM1 to interact with site-specific pentatricopeptide repeat protein editing factors. ORRM6 interacts with RIP1/MORF8, RIP2/MORF2, and RIP9/MORF9, known components of RNA editosomes. While some plastid RRM proteins are involved in other forms of RNA processing and translation, the primary function of ORRM6 is evidently to mediate psbF-C77 editing, like the essential site-specific pentatricopeptide repeat protein LOW PSII ACCUMULATION66. Stable expression in the orrm6 mutants of a nucleus-encoded, plastid-targeted PsbF protein from a psbF gene carrying a T at nucleotide 77 significantly increases leaf and plant sizes, chlorophyll content, and PSII activity. These transformants demonstrate that plastid RNA editing can be bypassed through the expression of nucleus-encoded, edited forms of plastid genes.

  10. Adaptive sampling for mesh spectrum editing

    Institute of Scientific and Technical Information of China (English)

    ZHAO Xiang-jun; ZHANG Hong-xin; BAO Hu-jun

    2006-01-01

    A mesh editing framework is presented in this paper, which integrates Free-Form Deformation (FFD) and geometry signal processing. By using simplified model from original mesh, the editing task can be accomplished with a few operations. We take the deformation of the proxy and the position coordinates of the mesh models as geometry signal. Wavelet analysis is employed to separate local detail information gracefully. The crucial innovation of this paper is a new adaptive regular sampling approach for our signal analysis based editing framework. In our approach, an original mesh is resampled and then refined iteratively which reflects optimization of our proposed spectrum preserving energy. As an extension of our spectrum editing scheme,the editing principle is applied to geometry details transferring, which brings satisfying results.

  11. TALEN-mediated genome editing: prospects and perspectives.

    Science.gov (United States)

    Wright, David A; Li, Ting; Yang, Bing; Spalding, Martin H

    2014-08-15

    Genome editing is the practice of making predetermined and precise changes to a genome by controlling the location of DNA DSBs (double-strand breaks) and manipulating the cell's repair mechanisms. This technology results from harnessing natural processes that have taken decades and multiple lines of inquiry to understand. Through many false starts and iterative technology advances, the goal of genome editing is just now falling under the control of human hands as a routine and broadly applicable method. The present review attempts to define the technique and capture the discovery process while following its evolution from meganucleases and zinc finger nucleases to the current state of the art: TALEN (transcription-activator-like effector nuclease) technology. We also discuss factors that influence success, technical challenges and future prospects of this quickly evolving area of study and application.

  12. TALEN-mediated genome editing: prospects and perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Wright, DA; Li, T; Yang, B; Spalding, MH

    2014-08-15

    Genome editing is the practice of making predetermined and precise changes to a genome by controlling the location of DNA DSBs (double-strand breaks) and manipulating the cell's repair mechanisms. This technology results from harnessing natural processes that have taken decades and multiple lines of inquiry to understand. Through many false starts and iterative technology advances, the goal of genome editing is just now falling under the control of human hands as a routine and broadly applicable method. The present review attempts to define the technique and capture the discovery process while following its evolution from meganucleases and zinc finger nucleases to the current state of the art: TALEN (transcription-activator-like effector nuclease) technology. We also discuss factors that influence success, technical challenges, and future prospects of this quickly evolving area of study and application.

  13. A TALE nuclease architecture for efficient genome editing.

    Science.gov (United States)

    Miller, Jeffrey C; Tan, Siyuan; Qiao, Guijuan; Barlow, Kyle A; Wang, Jianbin; Xia, Danny F; Meng, Xiangdong; Paschon, David E; Leung, Elo; Hinkley, Sarah J; Dulay, Gladys P; Hua, Kevin L; Ankoudinova, Irina; Cost, Gregory J; Urnov, Fyodor D; Zhang, H Steve; Holmes, Michael C; Zhang, Lei; Gregory, Philip D; Rebar, Edward J

    2011-02-01

    Nucleases that cleave unique genomic sequences in living cells can be used for targeted gene editing and mutagenesis. Here we develop a strategy for generating such reagents based on transcription activator-like effector (TALE) proteins from Xanthomonas. We identify TALE truncation variants that efficiently cleave DNA when linked to the catalytic domain of FokI and use these nucleases to generate discrete edits or small deletions within endogenous human NTF3 and CCR5 genes at efficiencies of up to 25%. We further show that designed TALEs can regulate endogenous mammalian genes. These studies demonstrate the effective application of designed TALE transcription factors and nucleases for the targeted regulation and modification of endogenous genes.

  14. A Comparison Study: Kaufman Assessment Battery for Children, Second Edition (KABC-II) and Wechsler Intelligence Scale for Children, Fourth Edition (WISC-IV) with Referred Students

    Science.gov (United States)

    McKown, Danielle M.

    2010-01-01

    This study was conducted based on the limited availability of research comparing the KABC-II and WISC-IV. The study included 30 Caucasian students between the ages of 6 years, 7 months to 16 years 11 months who attend rural school districts in Ohio and West Virginia and were referred due to academic concerns; the sample consisted of 19 females and…

  15. On the further development of the electronic edition «NANOTECHNOLOGIES IN CONSTRUCTION: A Scientific Internet-Journal» in 2015

    OpenAIRE

    GUSEV Boris Vladimirovich

    2015-01-01

    In 2015 the electronic edition «NANOTECHNOLOGIES IN CONSTRUCTION: A Scientific Internet-Journal» achieved a great success, it is recognized not only by Russian scientists but also foreign ones: • the geography of the edition’s authors has been enlarged, the new sections and columns have been introduced; • the edition has been included in the following citation systems (data bases): Global Impact Factor (Australia), EZB (Germany), ResearchGate (USA), DOAJ (Sweden); • the edition has b...

  16. High conservation of a 5' element required for RNA editing of a C target in chloroplast psbE transcripts.

    Science.gov (United States)

    Hayes, Michael L; Hanson, Maureen R

    2008-09-01

    C-to-U editing modifies 30-40 distinct nucleotides within higher-plant chloroplast transcripts. Many C targets are located at the same position in homologous genes from different plants; these either could have emerged independently or could share a common origin. The 5' sequence GCCGUU, required for editing of C214 in tobacco psbE in vitro, is one of the few identified editing cis-elements. We investigated psbE sequences from many plant species to determine in what lineage(s) editing of psbE C214 emerged and whether the cis-element identified in tobacco is conserved in plants with a C214. The GCCGUU sequence is present at a high frequency in plants that carry a C214 in psbE. However, Sciadopitys verticillata (Pinophyta) edits C214 despite the presence of nucleotide differences compared to the conserved cis-element. The C214 site in psbE genes is represented in members of four branches of spermatophytes but not in gnetophytes, resulting in the parsimonious prediction that editing of psbE C214 was present in the ancestor of spermatophytes. Extracts from chloroplasts from a species that has a difference in the motif and lacks the C target are incapable of editing tobacco psbE C214 substrates, implying that the critical trans-acting protein factors were not retained without a C target. Because noncoding sequences are less constrained than coding regions, we analyzed sequences 5' to two C editing targets located within coding regions to search for possible editing-related conserved elements. Putative editing cis-elements were uncovered in the 5' UTRs near editing sites psbL C2 and ndhD C2.

  17. Fuel Cell Handbook, Fifth Edition

    Energy Technology Data Exchange (ETDEWEB)

    Energy and Environmental Solutions

    2000-10-31

    Progress continues in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in November 1998. Uppermost, polymer electrolyte fuel cells, molten carbonate fuel cells, and solid oxide fuel cells have been demonstrated at commercial size in power plants. The previously demonstrated phosphoric acid fuel cells have entered the marketplace with more than 220 power plants delivered. Highlighting this commercial entry, the phosphoric acid power plant fleet has demonstrated 95+% availability and several units have passed 40,000 hours of operation. One unit has operated over 49,000 hours. Early expectations of very low emissions and relatively high efficiencies have been met in power plants with each type of fuel cell. Fuel flexibility has been demonstrated using natural gas, propane, landfill gas, anaerobic digester gas, military logistic fuels, and coal gas, greatly expanding market opportunities. Transportation markets worldwide have shown remarkable interest in fuel cells; nearly every major vehicle manufacturer in the U.S., Europe, and the Far East is supporting development. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultrahigh efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 8 describe the six major fuel cell types and their performance based on cell operating conditions. Alkaline and intermediate solid state fuel cells were added to this edition of the Handbook. New information indicates that manufacturers have stayed

  18. Guide Catalogues on Adjusting Industrial Structure 2011 Edition Revised and Published by the State

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    On March 27,National Development and Reform Commission published its No.9 order Guide Catalogues on Adjusting Industrial Structure (2011 Edition),to be implemented from June 1,2011.At the same time the Guide Catalogues on Adjusting Industrial Structure (2005 Edition) shall be abolished. Guide Catalogues on Adjusting Industrial Structure is an important reference for government to guide the investment direction,administrate investment projects,draw up and carry out fiscal and tax,financial,land,import and export policies.The revision of 2005 Edition keeps to the following principles:the first is to insist on the combination of market adjustment with government guidance;the second is to insist on the combination of traditional industrial upgrade with developing strategic emerging industries;the third is to insist on the combination of structural adjustment with coordinated development;and the fourth is to insist on the combination of controlling the total volume with optimizing the stock.The new catalogues aim to reflect the direction and content of structural adjustment and industrial upgrade.It lays much stress on the development and independent innovation of strategic emerging industries,and the limitation and guidance for industries with excess production capacity.The new edition keeps to the classification of 2005 Edition,and it's still divided into three categories including encouraged,limited and eliminated ones.Categories that do not belong to the above three categories,but still meet the requirements of national laws,regulations and policies arc defined as allowed category,which will not be included in the Catalogues.

  19. The origin of the lower fourth molar in canids, inferred by individual variation

    Directory of Open Access Journals (Sweden)

    Masakazu Asahara

    2016-11-01

    Full Text Available Background An increase in tooth number is an exception during mammalian evolution. The acquisition of the lower fourth molar in the bat-eared fox (Otocyon megalotis, Canidae, Carnivora, Mammalia is one example; however, its developmental origin is not clear. In some canids (Canidae, individual variation exist as supernumerary molar M4. This study focuses on the acquisition of the lower fourth molar in canids and proposes that the inhibitory cascade model can explain its origin. Methods Occlusal view projected area of lower molars was determined from 740 mandibles obtained from Canis latrans, Nyctereutes procyonoides, and Urocyon cinereoargenteus museum specimens. For each molar, relative sizes of molars (M2/M1 and M3/M1 scores affected by inhibition/activation dynamics during development, were compared between individuals with and without supernumerary molar (M4. Results Possession of a supernumerary molar was associated with significantly larger M2/M1 score in Canis latrans, M3/M1 score in Nyctereutes procyonoides, and M2/M1 and M3/M1 scores in Urocyon cinereoargenteus compared to individuals of these species that lacked supernumerary molars. Discussion We propose that, in canids, the supernumerary fourth molar is attributable to reduced inhibition and greater activation during molar development. In the bat-eared fox, altered inhibition and activation dynamics of dental development during omnivorous-insectivorous adaptation may be a contributing factor in the origin of the lower fourth molar.

  20. Combined search for the quarks of a sequential fourth generation

    Science.gov (United States)

    Chatrchyan, S.; Khachatryan, V.; Sirunyan, A. M.; Tumasyan, A.; Adam, W.; Aguilo, E.; Bergauer, T.; Dragicevic, M.; Erö, J.; Fabjan, C.; Friedl, M.; Frühwirth, R.; Ghete, V. M.; Hammer, J.; Hörmann, N.; Hrubec, J.; Jeitler, M.; Kiesenhofer, W.; Knünz, V.; Krammer, M.; Krätschmer, I.; Liko, D.; Mikulec, I.; Pernicka, M.; Rahbaran, B.; Rohringer, C.; Rohringer, H.; Schöfbeck, R.; Strauss, J.; Taurok, A.; Waltenberger, W.; Walzel, G.; Widl, E.; Wulz, C.-E.; Mossolov, V.; Shumeiko, N.; Suarez Gonzalez, J.; Bansal, M.; Bansal, S.; Cornelis, T.; De Wolf, E. A.; Janssen, X.; Luyckx, S.; Mucibello, L.; Ochesanu, S.; Roland, B.; Rougny, R.; Selvaggi, M.; Staykova, Z.; Van Haevermaet, H.; Van Mechelen, P.; Van Remortel, N.; Van Spilbeeck, A.; Blekman, F.; Blyweert, S.; D'Hondt, J.; Gonzalez Suarez, R.; Kalogeropoulos, A.; Maes, M.; Olbrechts, A.; Van Doninck, W.; Van Mulders, P.; Van Onsem, G. P.; Villella, I.; Clerbaux, B.; De Lentdecker, G.; Dero, V.; Gay, A. P. R.; Hreus, T.; Léonard, A.; Marage, P. E.; Mohammadi, A.; Reis, T.; Thomas, L.; Vander Marcken, G.; Vander Velde, C.; Vanlaer, P.; Wang, J.; Adler, V.; Beernaert, K.; Cimmino, A.; Costantini, S.; Garcia, G.; Grunewald, M.; Klein, B.; Lellouch, J.; Marinov, A.; Mccartin, J.; Ocampo Rios, A. A.; Ryckbosch, D.; Strobbe, N.; Thyssen, F.; Tytgat, M.; Verwilligen, P.; Walsh, S.; Yazgan, E.; Zaganidis, N.; Basegmez, S.; Bruno, G.; Castello, R.; Ceard, L.; Delaere, C.; du Pree, T.; Favart, D.; Forthomme, L.; Giammanco, A.; Hollar, J.; Lemaitre, V.; Liao, J.; Militaru, O.; Nuttens, C.; Pagano, D.; Pin, A.; Piotrzkowski, K.; Schul, N.; Vizan Garcia, J. M.; Beliy, N.; Caebergs, T.; Daubie, E.; Hammad, G. H.; Alves, G. A.; Correa Martins Junior, M.; De Jesus Damiao, D.; Martins, T.; Pol, M. E.; Souza, M. H. G.; Aldá Júnior, W. L.; Carvalho, W.; Custódio, A.; Da Costa, E. M.; De Oliveira Martins, C.; Fonseca De Souza, S.; Matos Figueiredo, D.; Mundim, L.; Nogima, H.; Oguri, V.; Prado Da Silva, W. L.; Santoro, A.; Soares Jorge, L.; Sznajder, A.; Anjos, T. S.; Bernardes, C. A.; Dias, F. A.; Tomei, T. R. Fernandez Perez; Gregores, E. M.; Lagana, C.; Marinho, F.; Mercadante, P. G.; Novaes, S. F.; Padula, Sandra S.; Genchev, V.; Iaydjiev, P.; Piperov, S.; Rodozov, M.; Stoykova, S.; Sultanov, G.; Tcholakov, V.; Trayanov, R.; Vutova, M.; Dimitrov, A.; Hadjiiska, R.; Kozhuharov, V.; Litov, L.; Pavlov, B.; Petkov, P.; Bian, J. G.; Chen, G. M.; Chen, H. S.; Jiang, C. H.; Liang, D.; Liang, S.; Meng, X.; Tao, J.; Wang, J.; Wang, X.; Wang, Z.; Xiao, H.; Xu, M.; Zang, J.; Zhang, Z.; Asawatangtrakuldee, C.; Ban, Y.; Guo, S.; Guo, Y.; Li, W.; Liu, S.; Mao, Y.; Qian, S. J.; Teng, H.; Wang, D.; Zhang, L.; Zhu, B.; Zou, W.; Avila, C.; Gomez, J. P.; Gomez Moreno, B.; Osorio Oliveros, A. F.; Sanabria, J. C.; Godinovic, N.; Lelas, D.; Plestina, R.; Polic, D.; Puljak, I.; Antunovic, Z.; Kovac, M.; Brigljevic, V.; Duric, S.; Kadija, K.; Luetic, J.; Morovic, S.; Attikis, A.; Galanti, M.; Mavromanolakis, G.; Mousa, J.; Nicolaou, C.; Ptochos, F.; Razis, P. A.; Finger, M.; Finger, M., Jr.; Assran, Y.; Elgammal, S.; Ellithi Kamel, A.; Khalil, S.; Mahmoud, M. A.; Radi, A.; Kadastik, M.; Müntel, M.; Raidal, M.; Rebane, L.; Tiko, A.; Eerola, P.; Fedi, G.; Voutilainen, M.; Härkönen, J.; Heikkinen, A.; Karimäki, V.; Kinnunen, R.; Kortelainen, M. J.; Lampén, T.; Lassila-Perini, K.; Lehti, S.; Lindén, T.; Luukka, P.; Mäenpää, T.; Peltola, T.; Tuominen, E.; Tuominiemi, J.; Tuovinen, E.; Ungaro, D.; Wendland, L.; Banzuzi, K.; Karjalainen, A.; Korpela, A.; Tuuva, T.; Besancon, M.; Choudhury, S.; Dejardin, M.; Denegri, D.; Fabbro, B.; Faure, J. L.; Ferri, F.; Ganjour, S.; Givernaud, A.; Gras, P.; Hamel de Monchenault, G.; Jarry, P.; Locci, E.; Malcles, J.; Millischer, L.; Nayak, A.; Rander, J.; Rosowsky, A.; Shreyber, I.; Titov, M.; Baffioni, S.; Beaudette, F.; Benhabib, L.; Bianchini, L.; Bluj, M.; Broutin, C.; Busson, P.; Charlot, C.; Daci, N.; Dahms, T.; Dobrzynski, L.; Granier de Cassagnac, R.; Haguenauer, M.; Miné, P.; Mironov, C.; Naranjo, I. N.; Nguyen, M.; Ochando, C.; Paganini, P.; Sabes, D.; Salerno, R.; Sirois, Y.; Veelken, C.; Zabi, A.; Agram, J.-L.; Andrea, J.; Bloch, D.; Bodin, D.; Brom, J.-M.; Cardaci, M.; Chabert, E. C.; Collard, C.; Conte, E.; Drouhin, F.; Ferro, C.; Fontaine, J.-C.; Gelé, D.; Goerlach, U.; Juillot, P.; Le Bihan, A.-C.; Van Hove, P.; Fassi, F.; Mercier, D.; Beauceron, S.; Beaupere, N.; Bondu, O.; Boudoul, G.; Chasserat, J.; Chierici, R.; Contardo, D.; Depasse, P.; El Mamouni, H.; Fay, J.; Gascon, S.; Gouzevitch, M.; Ille, B.; Kurca, T.; Lethuillier, M.; Mirabito, L.; Perries, S.; Sordini, V.; Tschudi, Y.; Verdier, P.; Viret, S.; Tsamalaidze, Z.; Anagnostou, G.; Beranek, S.; Edelhoff, M.; Feld, L.; Heracleous, N.; Hindrichs, O.; Jussen, R.

    2012-12-01

    Results are presented from a search for a fourth generation of quarks produced singly or in pairs in a data set corresponding to an integrated luminosity of 5fb-1 recorded by the CMS experiment at the LHC in 2011. A novel strategy has been developed for a combined search for quarks of the up and down type in decay channels with at least one isolated muon or electron. Limits on the mass of the fourth-generation quarks and the relevant Cabibbo-Kobayashi-Maskawa matrix elements are derived in the context of a simple extension of the standard model with a sequential fourth generation of fermions. The existence of mass-degenerate fourth-generation quarks with masses below 685 GeV is excluded at 95% confidence level for minimal off-diagonal mixing between the third- and the fourth-generation quarks. With a mass difference of 25 GeV between the quark masses, the obtained limit on the masses of the fourth-generation quarks shifts by about ±20GeV. These results significantly reduce the allowed parameter space for a fourth generation of fermions.

  1. The superior transvelar approach to the fourth ventricle and brainstem.

    Science.gov (United States)

    Ezer, Haim; Banerjee, Anirban Deep; Bollam, Papireddy; Guthikonda, Bharat; Nanda, Anil

    2012-06-01

    Objective The superior transvelar approach is used to access pathologies located in the fourth ventricle and brainstem. The surgical path is below the venous structures, through the superior medullary velum. Following splitting the tentorial edge, near the tentorial apex, the superior medullary velum is split in the cerebello-mesencephalic fissure. Using the supracerebellar infratentorial, transtentorial or parietal interhemispheric routes, the superior medullary velum is approached. Splitting this velum provides a detailed view of the fourth ventricle and its floor. Materials and Methods A total of 10 formalin-fixed specimens were dissected in a stepwise manner to simulate the superior transvelar approach to the fourth ventricle. The exposure gained the distance from the craniotomy site and the ease of access was assessed for each of the routes. We also present an illustrative case, operated by the senior author (AN). Results The superior transvelar approach provides access to the entire length of the fourth ventricle floor, from the aqueduct to the obex, when using the parietal interhemispheric route. In addition, this approach provides access to the entire width of the floor of the fourth ventricle; however, this requires retracting the superior cerebellar peduncle. Using the supracerebellar infratentorial route gives a limited exposure of the superior part of the fourth ventricle. The occipital interhemispheric route is a compromise between these two. Conclusion The superior transvelar approach to the fourth ventricle provides a route for approaching the fourth ventricle from above. This approach does not require opening the posterior fossa in the traditional way, and provides a reasonable alternative for accessing the superior fourth ventricle.

  2. PREFACE: Fourth International Workshop on Inelastic Ion-Surface Collisions

    Science.gov (United States)

    Sigmund, Peter

    1983-01-01

    The Fourth International Workshop on Inelastic Ion-Surface Collisions was held at Hindsgavl Manor near Middelfart, Denmark from 21 to 24 September 1982, following previous workshops held in Murray Hill, New Jersey (1976), Hamilton, Ontario (1978) and Feldkirchen-Westerham, Bavaria (1980). Like in the previous meetings, the underlying idea was to gather a moderately small group of researchers to discuss fundamental physical and chemical problems in a number of areas that are related, but are normally represented at separate conferences focusing on different aspects. The area of inelastic ion-surface collisions has a wide diversity of applications ranging from surface analysis by particle impact through microelectronic and controlled thermonuclear fusion devices to biomolecule identification and solar wind effects in planetary space. There are strong links to surface science and atomic collision physics and their respective applications. The present series of workshops is an attempt to focus on fundamental problems common to all these areas and thus to provide a forum for fruitful interaction. At Middelfart, we were lucky to have an exceptional number of well-presented and stimulating summary talks covering a rather broad range of fundamental processes with the emphasis shifting back and forth between collisional and surface aspects. Moreover, there was a wealth of short contributions on current research, of which many were submitted to the present proceedings. Thanks to the speakers, an active audience, and considerate session chairmen, we had extensive and lively but friendly discussions in an always stimulating atmosphere. This volume contains 11 of 13 invited papers and 15 of the 30 contributions presented orally at the workshop. It should, like the proceedings of the previous workshops, give a balanced survey of the current status of the field, with a slight bias toward recent developments like those in the theory of charge states of sputtered atoms, and others

  3. The SLO1 PPR protein is required for RNA editing at multiple sites with similar upstream sequences in Arabidopsis mitochondria.

    Science.gov (United States)

    Sung, Tzu-Ying; Tseng, Ching-Chih; Hsieh, Ming-Hsiun

    2010-08-01

    In Arabidopsis, RNA editing changes more than 500 cytidines to uridines in mitochondrial transcripts. The editing enzyme and co-factors involved in these processes are largely unknown. We have identified a nuclear gene SLOW GROWTH1 (SLO1) encoding an E motif-containing pentatricopeptide repeat protein that is required for RNA editing of nad4 and nad9 in Arabidopsis mitochondria. The SLO1 protein is localized to the mitochondrion, and its absence gives rise to small plants with slow growth and delayed development. A survey of approximately 500 mitochondrial RNA editing sites in Arabidopsis reveals that the editing of two sites, nad4-449 and nad9-328, is abolished in the slo1 mutants. Sequence comparison in the upstream (from -1 to -15 bp) of nad4-449 and nad9-328 editing sites shows that nine of the 15 nucleotides are identical. In addition to RNA editing, we used RNA gel blot analysis to compare the abundance and banding patterns of mitochondrial transcripts between the wild type and slo1 mutants. Of the 79 genes and open reading frames examined, steady-state levels of 56 mitochondrial transcripts are increased in the slo1 mutants. These results suggest that the SLO1 protein may indirectly regulate plant growth and development via affecting mitochondrial RNA editing and gene expression.

  4. Fourth generation effects in rare exclusive $B \\to K^{*}1^{+}l^{-}$ decay

    CERN Document Server

    Aliev, T M; Savci, M

    2000-01-01

    Influence of the fourth generation, if ever exists, on the experimentallymeasurable quantities such as invariant dilepton mass distribution, leptonforward-backward asymmetry, and the ratio (Gamma_L/Gamma_T) of the decay widthswhen K* meson is longitudinally and transversally polarized, is studied. Usingthe experimental results on the branching ratios for the (B -> X_s) gamma andsemileptonic (B -> X_c l nu) decays, the two possible solutions of the 4x4Cabibbo-Kobayashi-Maskawa factor (V_{t's} V_{t^'b}) are obtained as a functionof the t'-quark mass. It is observed that the results for the above-mentionedphysical quantities are essentially different from the standard modelpredictions only for one solution of the CKM factor. In this case theabove-mentioned physical quantities can serve as efficient tools in search ofthe fourth generation. The other solution yields almost identical results withthe SM.

  5. Image editing with spatiograms transfer.

    Science.gov (United States)

    Papadakis, Nicolas; Bugeau, Aurélie; Caselles, Vicent

    2012-05-01

    Histogram equalization is a well-known method for image contrast enhancement. Nevertheless, as histograms do not include any information on the spatial repartition of colors, their application to local image editing problems remains limited. To cope with this lack of spatial information, spatiograms have been recently proposed for tracking purposes. A spatiogram is an image descriptor that combines a histogram with the mean and the variance of the position of each color. In this paper, we address the problem of local retouching of images by proposing a variational method for spatiogram transfer. More precisely, a reference spatiogram is used to modify the color value of a given region of interest of the processed image. Experiments on shadow removal and inpainting demonstrate the strength of the proposed approach.

  6. AAO Observer - August 2011 Edition

    CERN Document Server

    Brough, Sarah

    2011-01-01

    This edition of the Australian Astronomical Observatory Observer contains articles on the commissioning of the new SAMI instrument giving the first hexabundle galaxy spectra; galaxy parameter variations across and through the 6dFGS Fundamental Plane; an introduction to the new Dragonfly stellar interferometer; an update on the RAdial VElocity (RAVE) survey at half a million spectra; the Magellanic Quasars Survey; the Integrated Photonic Spectrograph's first look at the heart of the Scorpion; using AAOMega to measure the age of the young open cluster IC2602; making MANIFEST fibres for the Giant Magellan Telescope and a Voyage through Filaments of Galaxies. The Observer also contains thoughts on diversity in the astronomy community and reports on the recent Supernovae and their Host Galaxies conference and the 2011 Science Meets Parliament. In addition there are the usual features of the AUSGO Corner, Epping News and Letter from Coona.

  7. Genome edited animals: Learning from GM crops?

    Science.gov (United States)

    Bruce, Ann

    2017-06-01

    Genome editing of livestock is poised to become commercial reality, yet questions remain as to appropriate regulation, potential impact on the industry sector and public acceptability of products. This paper looks at how genome editing of livestock has attempted to learn some of the lessons from commercialisation of GM crops, and takes a systemic approach to explore some of the complexity and ambiguity in incorporating genome edited animals in a food production system. Current applications of genome editing are considered, viewed from the perspective of past technological applications. The question of what is genome editing, and can it be considered natural is examined. The implications of regulation on development of different sectors of livestock production systems are studied, with a particular focus on the veterinary sector. From an EU perspective, regulation of genome edited animals, although not necessarily the same as for GM crops, is advocated from a number of different perspectives. This paper aims to open up new avenues of research on genome edited animals, extending from the current primary focus on science and regulation, to engage with a wider-range of food system actors.

  8. Yangzhou’s Famous Twenty-fourth Bridge

    Institute of Scientific and Technical Information of China (English)

    1992-01-01

    “LOOMING green moun-tains and runningstreams;grass does notwither and fall,though the autumnhas come to an end in the south.The bright moon arises overTwenty-fourth Bridge.Where doyou teach pure-jade Yangzhouwomen to play music on bambooflutes?”This poem by Du Mu(803-c.852),a famous poet of thelate Tang Dynasty,is well remem-bered today It made Yangzhou’sTwenty-fourth Bridge Known to la-ter generations.Of many ancientpoems about Twenty-fourth Bridge

  9. Fourth-order partial differential equations for effective image denoising

    Directory of Open Access Journals (Sweden)

    Seongjai Kim

    2009-04-01

    Full Text Available This article concerns mathematical image denoising methods incorporating fourth-order partial differential equations (PDEs. We introduce and analyze piecewise planarity conditions (PPCs with which unconstrained fourth-order variational models in continuum converge to a piecewise planar image. It has been observed that fourth-order variational models holding PPCs can restore better images than models without PPCs and second-order models. Numerical schemes are presented in detail and various examples in image denoising are provided to verify the claim.

  10. A population-based evaluation of the seventh edition of the TNM system for lung cancer

    DEFF Research Database (Denmark)

    Strand, T-E; Rostad, H; Wentzel-Larsen, T

    2010-01-01

    Our study describes the new seventh edition of the TNM system for lung cancer in a national population and its clinical implications. We classified 1,885 operated patients with lung cancer, reported to the Cancer Registry of Norway (Oslo, Norway) from 2001 to 2005, according to the sixth and the ......Our study describes the new seventh edition of the TNM system for lung cancer in a national population and its clinical implications. We classified 1,885 operated patients with lung cancer, reported to the Cancer Registry of Norway (Oslo, Norway) from 2001 to 2005, according to the sixth...... and the seventh edition of the TNM system. We compared survival differences adjusting for known prognostic factors. Furthermore, we evaluated the overall predictive ability of both editions using Harrell's concordance index. Survival curves by stage for each of the editions were similar; however, a better...... to stage II and 161 (48%) patients migrated from stage IIB to IIA. Stage migrations could change the treatment for up to 326 (17.3%) of the study patients. The seventh edition did not improve the overall predictive ability of the TNM system; however, the new classification implies changes in treatment...

  11. Data Director editor user's manual. [EDIT

    Energy Technology Data Exchange (ETDEWEB)

    McGoldrick, P.

    1977-03-21

    EDIT allows the user to edit or create text, either interactively or in the batch mode. The text may be a source program, program data, or documents. Special provisions permit the creation or editing of APT source-language programs. EDIT processes ASCII files from any accessible Data Director library and outputs files to any such library as specified by the user.

  12. The SKI*HI Model: Programming for Hearing Impaired Infants through Home Intervention, Home Visit Curriculum. Fourth Edition.

    Science.gov (United States)

    Clark, Thomas C.; Watkins, Susan

    The manual describes the SKI*HI Model, a comprehensive approach to identification and home intervention treatment of hearing impaired children and their families. The model features home programing in four basic areas: the home hearing aid program (nine lessons which facilitate the proper fit and acceptance of amplification by the child), home…

  13. Should borderline personality disorder be included in the fourth edition of the Chinese classification of mental disorders?

    Institute of Scientific and Technical Information of China (English)

    ZHONG Jie; LEUNG Freedom

    2007-01-01

    @@ Borderline personality disorder (BPD) is a serious Bpersonality disorder characterized by a pervasive pattern of disturbances in mood regulation, impulse control, self-image and interpersonal relationships.1 In the United States, the prevalence of BPD has been estimated at 1%-2% of the general population, 10% of psychiatric outpatients, and 20% of inpatients.2,3 According to the 4th text revision of diagnostic and statistical manual of mental disorders (DSM-Ⅳ-TR),1 about 75% of BPD patients are women. The BPD diagnosis has been associated with heightened risk (8.5% to 10.0% among BPD patients) for completed suicide, a rate almost 50times higher than in the general population.4

  14. Intelligent Testing with Wechsler’s Fourth Editions: Perspectives on the Weiss et al. Studies and the Eight Commentaries

    Science.gov (United States)

    Kaufman, Alan S.

    2013-01-01

    The two featured articles and eight commentaries on the WISC-IV (Wechsler, 2003) and WAIS-IV (Wechsler, 2008) in this special issue of "Journal of Psychoeducational Assessment" are of exceptional quality. As a collective, this special issue greatly advances the field of cognitive assessment by intelligently synthesizing the best of…

  15. Intelligent Testing with Wechsler’s Fourth Editions: Perspectives on the Weiss et al. Studies and the Eight Commentaries

    Science.gov (United States)

    Kaufman, Alan S.

    2013-01-01

    The two featured articles and eight commentaries on the WISC-IV (Wechsler, 2003) and WAIS-IV (Wechsler, 2008) in this special issue of "Journal of Psychoeducational Assessment" are of exceptional quality. As a collective, this special issue greatly advances the field of cognitive assessment by intelligently synthesizing the best of…

  16. Editing CCR5: a novel approach to HIV gene therapy.

    Science.gov (United States)

    Cornu, Tatjana I; Mussolino, Claudio; Bloom, Kristie; Cathomen, Toni

    2015-01-01

    Acquired immunodeficiency syndrome (AIDS) is a life-threatening disorder caused by infection of individuals with the human immunodeficiency virus (HIV). Entry of HIV-1 into target cells depends on the presence of two surface proteins on the cell membrane: CD4, which serves as the main receptor, and either CCR5 or CXCR4 as a co-receptor. A limited number of people harbor a genomic 32-bp deletion in the CCR5 gene (CCR5∆32), leading to expression of a truncated gene product that provides resistance to HIV-1 infection in individuals homozygous for this mutation. Moreover, allogeneic hematopoietic stem cell (HSC) transplantation with CCR5∆32 donor cells seems to confer HIV-1 resistance to the recipient as well. However, since Δ32 donors are scarce and allogeneic HSC transplantation is not exempt from risks, the development of gene editing tools to knockout CCR5 in the genome of autologous cells is highly warranted. Targeted gene editing can be accomplished with designer nucleases, which essentially are engineered restriction enzymes that can be designed to cleave DNA at specific sites. During repair of these breaks, the cellular repair pathway often introduces small mutations at the break site, which makes it possible to disrupt the ability of the targeted locus to express a functional protein, in this case CCR5. Here, we review the current promise and limitations of CCR5 gene editing with engineered nucleases, including factors affecting the efficiency of gene disruption and potential off-target effects.

  17. Newer Gene Editing Technologies toward HIV Gene Therapy

    Directory of Open Access Journals (Sweden)

    Premlata Shankar

    2013-11-01

    Full Text Available Despite the great success of highly active antiretroviral therapy (HAART in ameliorating the course of HIV infection, alternative therapeutic approaches are being pursued because of practical problems associated with life-long therapy. The eradication of HIV in the so-called “Berlin patient” who received a bone marrow transplant from a CCR5-negative donor has rekindled interest in genome engineering strategies to achieve the same effect. Precise gene editing within the cells is now a realistic possibility with recent advances in understanding the DNA repair mechanisms, DNA interaction with transcription factors and bacterial defense mechanisms. Within the past few years, four novel technologies have emerged that can be engineered for recognition of specific DNA target sequences to enable site-specific gene editing: Homing Endonuclease, ZFN, TALEN, and CRISPR/Cas9 system. The most recent CRISPR/Cas9 system uses a short stretch of complementary RNA bound to Cas9 nuclease to recognize and cleave target DNA, as opposed to the previous technologies that use DNA binding motifs of either zinc finger proteins or transcription activator-like effector molecules fused to an endonuclease to mediate sequence-specific DNA cleavage. Unlike RNA interference, which requires the continued presence of effector moieties to maintain gene silencing, the newer technologies allow permanent disruption of the targeted gene after a single treatment. Here, we review the applications, limitations and future prospects of novel gene-editing strategies for use as HIV therapy.

  18. Newer gene editing technologies toward HIV gene therapy.

    Science.gov (United States)

    Manjunath, N; Yi, Guohua; Dang, Ying; Shankar, Premlata

    2013-11-14

    Despite the great success of highly active antiretroviral therapy (HAART) in ameliorating the course of HIV infection, alternative therapeutic approaches are being pursued because of practical problems associated with life-long therapy. The eradication of HIV in the so-called "Berlin patient" who received a bone marrow transplant from a CCR5-negative donor has rekindled interest in genome engineering strategies to achieve the same effect. Precise gene editing within the cells is now a realistic possibility with recent advances in understanding the DNA repair mechanisms, DNA interaction with transcription factors and bacterial defense mechanisms. Within the past few years, four novel technologies have emerged that can be engineered for recognition of specific DNA target sequences to enable site-specific gene editing: Homing Endonuclease, ZFN, TALEN, and CRISPR/Cas9 system. The most recent CRISPR/Cas9 system uses a short stretch of complementary RNA bound to Cas9 nuclease to recognize and cleave target DNA, as opposed to the previous technologies that use DNA binding motifs of either zinc finger proteins or transcription activator-like effector molecules fused to an endonuclease to mediate sequence-specific DNA cleavage. Unlike RNA interference, which requires the continued presence of effector moieties to maintain gene silencing, the newer technologies allow permanent disruption of the targeted gene after a single treatment. Here, we review the applications, limitations and future prospects of novel gene-editing strategies for use as HIV therapy.

  19. The radial velocity experiment (RAVE) : Fourth data release

    NARCIS (Netherlands)

    Kordopatis, G.; Gilmore, G.; Steinmetz, M.; Boeche, C.; Seabroke, G. M.; Siebert, A.; Zwitter, T.; Binney, J.; de Laverny, P.; Recio-Blanco, A.; Williams, M. E. K.; Piffl, T.; Enke, H.; Roeser, S.; Bijaoui, A.; Wyse, R. F. G.; Freeman, K.; Munari, U.; Carrillo, I.; Anguiano, B.; Burton, D.; Campbell, R.; Cass, C. J. P.; Fiegert, K.; Hartley, M.; Parker, Q. A.; Reid, W.; Ritter, A.; Russell, K. S.; Stupar, M.; Watson, F. G.; Bienayme, O.; Bland-Hawthorn, J.; Gerhard, O.; Gibson, B. K.; Grebel, E. K.; Helmi, A.; Navarro, J. F.; Conrad, C.; Famaey, B.; Faure, C.; Just, A.; Kos, J.; Matijevic, G.; McMillan, P. J.; Minchev, I.; Scholz, R.; Sharma, S.; Siviero, A.; de Boer, E. Wylie; Zerjal, M.

    2013-01-01

    We present the stellar atmospheric parameters (effective temperature, surface gravity, overall metallicity), radial velocities, individual abundances, and distances determined for 425,561 stars, which constitute the fourth public data release of the RAdial Velocity Experiment (RAVE). The stellar atm

  20. Development of neurogenic stress cardiomyopathy after fourth ventricle tumor surgery

    Directory of Open Access Journals (Sweden)

    D. A. Doroshenko

    2014-07-01

    Full Text Available The paper describes a clinical case of the development of neurogenic stress cardiomyopathy that had the characteristics of Takotsubo cardiomyopathyin a young female patient in the early periods after fourth ventricle tumor surgery.

  1. Development of neurogenic stress cardiomyopathy after fourth ventricle tumor surgery

    Directory of Open Access Journals (Sweden)

    D. A. Doroshenko

    2012-01-01

    Full Text Available The paper describes a clinical case of the development of neurogenic stress cardiomyopathy that had the characteristics of Takotsubo cardiomyopathyin a young female patient in the early periods after fourth ventricle tumor surgery.

  2. The Radial Velocity Experiment (RAVE): Fourth Data Release

    NARCIS (Netherlands)

    Kordopatis, G.; Gilmore, G.; Steinmetz, M.; Boeche, C.; Seabroke, G. M.; Siebert, A.; Zwitter, T.; Binney, J.; de Laverny, P.; Recio-Blanco, A.; Williams, M. E. K.; Piffl, T.; Enke, H.; Roeser, S.; Bijaoui, A.; Wyse, R. F. G.; Freeman, K.; Munari, U.; Carrillo, I.; Anguiano, B.; Burton, D.; Campbell, R.; Cass, C. J. P.; Fiegert, K.; Hartley, M.; Parker, Q. A.; Reid, W.; Ritter, A.; Russell, K. S.; Stupar, M.; Watson, F. G.; Bienaymé, O.; Bland-Hawthorn, J.; Gerhard, O.; Gibson, B. K.; Grebel, E. K.; Helmi, A.; Navarro, J. F.; Conrad, C.; Famaey, B.; Faure, C.; Just, A.; Kos, J.; Matijevič, G.; McMillan, P. J.; Minchev, I.; Scholz, R.; Sharma, S.; Siviero, A.; de Boer, E. Wylie; Žerjal, M.

    2013-01-01

    We present the stellar atmospheric parameters (effective temperature, surface gravity, overall metallicity), radial velocities, individual abundances, and distances determined for 425,561 stars, which constitute the fourth public data release of the RAdial Velocity Experiment (RAVE). The stellar atm

  3. Suicide attempts and psychological risk factors in patients with bipolar and unipolar affective disorder.

    Science.gov (United States)

    Pawlak, Joanna; Dmitrzak-Węglarz, Monika; Skibińska, Maria; Szczepankiewicz, Aleksandra; Leszczyńska-Rodziewicz, Anna; Rajewska-Rager, Aleksandra; Maciukiewicz, Małgorzata; Czerski, Piotr; Hauser, Joanna

    2013-01-01

    Suicide is an important clinical problem in psychiatric patients. The highest risk of suicide attempts is noted in affective disorders. The aim of the study was looking for suicide risk factors among personality dimensions and value system in patients with diagnosis of unipolar and bipolar affective disorder (n=189 patients, n=101 controls). To establish the diagnosis, we used SCID (Structured clinical interview for diagnostic and statistical manual of mental disorders, fourth edition) questionnaire, TCI (Temperament and Character Inventory) questionnaire and Value Survey--to assess the personality. The main limitations of the study are number of participants, lack of data about stressful life events and treatment with lithium. Novelty seeking and harm avoidance dimensions constituted suicide attempt risk factors in the group of patients with affective disorders. Protective role of cooperativeness was discovered. Patients with and without suicide attempt in lifetime history varied in self-esteem position in Value Survey.

  4. The Latent Factor Structure of Acute Stress Disorder following Bank Robbery

    DEFF Research Database (Denmark)

    Hansen, M.; Lasgaard, M.; Elklit, A.

    2013-01-01

    OBJECTIVE: Acute stress disorder (ASD) was introduced into the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV; American Psychiatric Association, 1994) to identify posttraumatic stress reactions occurring within the first month after a trauma and thus help...... for the ASD diagnosis in the pending DSM-5, there is a profound need for empirical studies that investigate the latent structure of ASD prior to the DSM-5 being finalized. DESIGN: Based on previous factor analytic research, the DSM-IV, and the proposed DSM-5 formulation of ASD, four different models...... of the latent structure of ASD were specified and estimated. METHOD: The analyses were based on a national study of bank robbery victims (N = 450) using the acute stress disorder scale. RESULTS: The results of the confirmatory factor analyses showed that the DSM-IV model provided the best fit to the data. Thus...

  5. Acronyms, initialisms, and abbreviations: Fourth Revision

    Energy Technology Data Exchange (ETDEWEB)

    Tolman, B.J. [comp.

    1994-04-01

    This document lists acronyms used in technical writing. The immense list is supplemented by an appendix containing chemical elements, classified information access, common abbreviations used for functions, conversion factors for selected SI units, a flowcharting template, greek alphabet, metrix terminology, proofreader`s marks, signs and symbols, and state abbreviations.

  6. Developmental competence of porcine genome-edited zygotes.

    Science.gov (United States)

    Gil, Maria A; Martinez, Cristina A; Nohalez, Alicia; Parrilla, Inmaculada; Roca, Jordi; Wu, Jun; Ross, Pablo J; Cuello, Cristina; Izpisua, Juan C; Martinez, Emilio A

    2017-09-01

    Genome editing in pigs has tremendous practical applications for biomedicine. The advent of genome editing technology, with its use of site-specific nucleases-including ZFNs, TALENs, and the CRISPR/Cas9 system-has popularized targeted zygote genome editing via one-step microinjection in several mammalian species. Here, we review methods to optimize the developmental competence of genome-edited porcine embryos and strategies to improve the zygote genome-editing efficiency in pigs. © 2017 Wiley Periodicals, Inc.

  7. Combined search for the quarks of a sequential fourth generation

    CERN Document Server

    Chatrchyan, Serguei; Sirunyan, Albert M; Tumasyan, Armen; Adam, Wolfgang; Aguilo, Ernest; Bergauer, Thomas; Dragicevic, Marko; Erö, Janos; Fabjan, Christian; Friedl, Markus; Fruehwirth, Rudolf; Ghete, Vasile Mihai; Hammer, Josef; Hörmann, Natascha; Hrubec, Josef; Jeitler, Manfred; Kiesenhofer, Wolfgang; Knünz, Valentin; Krammer, Manfred; Krätschmer, Ilse; Liko, Dietrich; Mikulec, Ivan; Pernicka, Manfred; Rahbaran, Babak; Rohringer, Christine; Rohringer, Herbert; Schöfbeck, Robert; Strauss, Josef; Taurok, Anton; Waltenberger, Wolfgang; Walzel, Gerhard; Widl, Edmund; Wulz, Claudia-Elisabeth; Mossolov, Vladimir; Shumeiko, Nikolai; Suarez Gonzalez, Juan; Bansal, Monika; Bansal, Sunil; Cornelis, Tom; De Wolf, Eddi A; Janssen, Xavier; Luyckx, Sten; Mucibello, Luca; Ochesanu, Silvia; Roland, Benoit; Rougny, Romain; Selvaggi, Michele; Staykova, Zlatka; Van Haevermaet, Hans; Van Mechelen, Pierre; Van Remortel, Nick; Van Spilbeeck, Alex; Blekman, Freya; Blyweert, Stijn; D'Hondt, Jorgen; Gonzalez Suarez, Rebeca; Kalogeropoulos, Alexis; Maes, Michael; Olbrechts, Annik; Van Doninck, Walter; Van Mulders, Petra; Van Onsem, Gerrit Patrick; Villella, Ilaria; Clerbaux, Barbara; De Lentdecker, Gilles; Dero, Vincent; Gay, Arnaud; Hreus, Tomas; Léonard, Alexandre; Marage, Pierre Edouard; Mohammadi, Abdollah; Reis, Thomas; Thomas, Laurent; Vander Marcken, Gil; Vander Velde, Catherine; Vanlaer, Pascal; Wang, Jian; Adler, Volker; Beernaert, Kelly; Cimmino, Anna; Costantini, Silvia; Garcia, Guillaume; Grunewald, Martin; Klein, Benjamin; Lellouch, Jérémie; Marinov, Andrey; Mccartin, Joseph; Ocampo Rios, Alberto Andres; Ryckbosch, Dirk; Strobbe, Nadja; Thyssen, Filip; Tytgat, Michael; Verwilligen, Piet; Walsh, Sinead; Yazgan, Efe; Zaganidis, Nicolas; Basegmez, Suzan; Bruno, Giacomo; Castello, Roberto; Ceard, Ludivine; Delaere, Christophe; Du Pree, Tristan; Favart, Denis; Forthomme, Laurent; Giammanco, Andrea; Hollar, Jonathan; Lemaitre, Vincent; Liao, Junhui; Militaru, Otilia; Nuttens, Claude; Pagano, Davide; Pin, Arnaud; Piotrzkowski, Krzysztof; Schul, Nicolas; Vizan Garcia, Jesus Manuel; Beliy, Nikita; Caebergs, Thierry; Daubie, Evelyne; Hammad, Gregory Habib; Alves, Gilvan; Correa Martins Junior, Marcos; De Jesus Damiao, Dilson; Martins, Thiago; Pol, Maria Elena; Henrique Gomes E Souza, Moacyr; Aldá Júnior, Walter Luiz; Carvalho, Wagner; Custódio, Analu; Da Costa, Eliza Melo; De Oliveira Martins, Carley; Fonseca De Souza, Sandro; Matos Figueiredo, Diego; Mundim, Luiz; Nogima, Helio; Oguri, Vitor; Prado Da Silva, Wanda Lucia; Santoro, Alberto; Soares Jorge, Luana; Sznajder, Andre; Souza Dos Anjos, Tiago; Bernardes, Cesar Augusto; De Almeida Dias, Flavia; Tomei, Thiago; De Moraes Gregores, Eduardo; Lagana, Caio; Da Cunha Marinho, Franciole; Mercadante, Pedro G; Novaes, Sergio F; Padula, Sandra; Genchev, Vladimir; Iaydjiev, Plamen; Piperov, Stefan; Rodozov, Mircho; Stoykova, Stefka; Sultanov, Georgi; Tcholakov, Vanio; Trayanov, Rumen; Vutova, Mariana; Dimitrov, Anton; Hadjiiska, Roumyana; Kozhuharov, Venelin; Litov, Leander; Pavlov, Borislav; Petkov, Peicho; Bian, Jian-Guo; Chen, Guo-Ming; Chen, He-Sheng; Jiang, Chun-Hua; Liang, Dong; Liang, Song; Meng, Xiangwei; Tao, Junquan; Wang, Jian; Wang, Xianyou; Wang, Zheng; Xiao, Hong; Xu, Ming; Zang, Jingjing; Zhang, Zhen; Asawatangtrakuldee, Chayanit; Ban, Yong; Guo, Shuang; Guo, Yifei; Li, Wenbo; Liu, Shuai; Mao, Yajun; Qian, Si-Jin; Teng, Haiyun; Wang, Dayong; Zhang, Linlin; Zhu, Bo; Zou, Wei; Avila, Carlos; Gomez, Juan Pablo; Gomez Moreno, Bernardo; Osorio Oliveros, Andres Felipe; Sanabria, Juan Carlos; Godinovic, Nikola; Lelas, Damir; Plestina, Roko; Polic, Dunja; Puljak, Ivica; Antunovic, Zeljko; Kovac, Marko; Brigljevic, Vuko; Duric, Senka; Kadija, Kreso; Luetic, Jelena; Morovic, Srecko; Attikis, Alexandros; Galanti, Mario; Mavromanolakis, Georgios; Mousa, Jehad; Nicolaou, Charalambos; Ptochos, Fotios; Razis, Panos A; Finger, Miroslav; Finger Jr, Michael; Assran, Yasser; Elgammal, Sherif; Ellithi Kamel, Ali; Khalil, Shaaban; Mahmoud, Mohammed; Radi, Amr; Kadastik, Mario; Müntel, Mait; Raidal, Martti; Rebane, Liis; Tiko, Andres; Eerola, Paula; Fedi, Giacomo; Voutilainen, Mikko; Härkönen, Jaakko; Heikkinen, Mika Aatos; Karimäki, Veikko; Kinnunen, Ritva; Kortelainen, Matti J; Lampén, Tapio; Lassila-Perini, Kati; Lehti, Sami; Lindén, Tomas; Luukka, Panja-Riina; Mäenpää, Teppo; Peltola, Timo; Tuominen, Eija; Tuominiemi, Jorma; Tuovinen, Esa; Ungaro, Donatella; Wendland, Lauri; Banzuzi, Kukka; Karjalainen, Ahti; Korpela, Arja; Tuuva, Tuure; Besancon, Marc; Choudhury, Somnath

    2012-01-01

    Results are presented from a search for a fourth generation of quarks produced singly or in pairs in a data set corresponding to an integrated luminosity of 5 inverse femtobarns recorded by the CMS experiment at the LHC in 2011. A novel strategy has been developed for a combined search for quarks of the up- and down-type in decay channels with at least one isolated muon or electron. Limits on the mass of the fourth-generation quarks and the relevant CKM matrix elements are derived in the context of a simple extension of the standard model with a sequential fourth generation of fermions. The existence of mass-degenerate fourth-generation quarks with masses below 685 GeV is excluded at 95% confidence level for minimal off-diagonal mixing between the third- and the fourth-generation quarks. With a mass difference of 25 GeV between the quark masses, the obtained limit on the masses of the fourth-generation quarks shifts by about +/- 20 GeV. This result significantly reduces the allowed parameter space for a fourt...

  8. Specification Editing and Discovery Assistant Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The project will prototype a specification editing and discovery tool (SPEEDY) for C/C++ that will assist software developers with modular formal verification tasks...

  9. Geographic Response Plan (GRP) Sensitive Sites (editable)

    Data.gov (United States)

    U.S. Environmental Protection Agency — This is an editable point feature data set with points over Apra Harbor in Guam. These points represent sensitive sites such as access points for public use and...

  10. LabVIEW 8 student edition

    CERN Document Server

    Bishop, Robert H

    2007-01-01

    For courses in Measurement and Instrumentation, Electrical Engineering lab, and Physics and Chemistry lab. This revised printing has been updated to include new LabVIEW 8.2 Student Edition. National Instruments' LabVIEW is the defacto industry standard for test, measurement, and automation software solutions. With the Student Edition of LabVIEW, students can design graphical programming solutions to their classroom problems and laboratory experiments with software that delivers the graphical programming capabilites of the LabVIEW professional version. . The Student Edition is also compatible with all National Instruments data acquisition and instrument control hardware. Note: The LabVIEW Student Edition is available to students, faculty, and staff for personal educational use only. It is not intended for research, institutional, or commercial use. For more information about these licensing options, please visit the National Instruments website at (http:www.ni.com/academic/)

  11. Research Review: Magazine Editors and Editing Practices.

    Science.gov (United States)

    Jolliffe, Lee

    1994-01-01

    Reviews and critiques literature in the subfield of magazine editing research, chiefly biographical studies of individual editors and various types of studies of editorial practices, including surveys, magazine content analyses, and close qualitative examinations of editors' relationships with others. (SR)

  12. Wetland Ecology Principles and Conservation, Second Edition

    OpenAIRE

    Richard Smardon

    2014-01-01

    This is a book review of Wetland Ecology Principles and Conservation, second edition, by Paul Keddy. This review focuses on the book’s content as it relates to wetland sustainability for both science and management. Besides overall comments, comparisons are made with the first edition of the book and then very specific chapter-by-chapter relationships to wetland sustainability are made to illustrate specific applications toward wetland sustainability.

  13. Looking forward to genetically edited fruit crops.

    Science.gov (United States)

    Nagamangala Kanchiswamy, Chidananda; Sargent, Daniel James; Velasco, Riccardo; Maffei, Massimo E; Malnoy, Mickael

    2015-02-01

    The availability of genome sequences for many fruit crops has redefined the boundaries of genetic engineering and genetically modified (GM) crop plants. However commercialization of GM crops is hindered by numerous regulatory and social hurdles. Here, we focus on recently developed genome-editing tools for fruit crop improvement and their importance from the consumer perspective. Challenges and opportunities for the deployment of new genome-editing tools for fruit plants are also discussed.

  14. Non-GMO genetically edited crop plants.

    Science.gov (United States)

    Kanchiswamy, Chidananda Nagamangala; Malnoy, Mickael; Velasco, Riccardo; Kim, Jin-Soo; Viola, Roberto

    2015-09-01

    Direct delivery of purified Cas9 protein with guide RNA into plant cells, as opposed to plasmid-mediated delivery, displays high efficiency and reduced off-target effects. Following regeneration from edited cells, the ensuing plant is also likely to bypass genetically modified organism (GMO) legislation as the genome editing complex is degraded in the recipient cells. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Approximate Graph Edit Distance in Quadratic Time.

    Science.gov (United States)

    Riesen, Kaspar; Ferrer, Miquel; Bunke, Horst

    2015-09-14

    Graph edit distance is one of the most flexible and general graph matching models available. The major drawback of graph edit distance, however, is its computational complexity that restricts its applicability to graphs of rather small size. Recently the authors of the present paper introduced a general approximation framework for the graph edit distance problem. The basic idea of this specific algorithm is to first compute an optimal assignment of independent local graph structures (including substitutions, deletions, and insertions of nodes and edges). This optimal assignment is complete and consistent with respect to the involved nodes of both graphs and can thus be used to instantly derive an admissible (yet suboptimal) solution for the original graph edit distance problem in O(n3) time. For large scale graphs or graph sets, however, the cubic time complexity may still be too high. Therefore, we propose to use suboptimal algorithms with quadratic rather than cubic time for solving the basic assignment problem. In particular, the present paper introduces five different greedy assignment algorithms in the context of graph edit distance approximation. In an experimental evaluation we show that these methods have great potential for further speeding up the computation of graph edit distance while the approximated distances remain sufficiently accurate for graph based pattern classification.

  16. The commercialization of genome-editing technologies.

    Science.gov (United States)

    Brinegar, Katelyn; K Yetisen, Ali; Choi, Sun; Vallillo, Emily; Ruiz-Esparza, Guillermo U; Prabhakar, Anand M; Khademhosseini, Ali; Yun, Seok-Hyun

    2017-11-01

    The emergence of new gene-editing technologies is profoundly transforming human therapeutics, agriculture, and industrial biotechnology. Advances in clustered regularly interspaced short palindromic repeats (CRISPR) have created a fertile environment for mass-scale manufacturing of cost-effective products ranging from basic research to translational medicine. In our analyses, we evaluated the patent landscape of gene-editing technologies and found that in comparison to earlier gene-editing techniques, CRISPR has gained significant traction and this has established dominance. Although most of the gene-editing technologies originated from the industry, CRISPR has been pioneered by academic research institutions. The spinout of CRISPR biotechnology companies from academic institutions demonstrates a shift in entrepreneurship strategies that were previously led by the industry. These academic institutions, and their subsequent companies, are competing to generate comprehensive intellectual property portfolios to rapidly commercialize CRISPR products. Our analysis shows that the emergence of CRISPR has resulted in a fivefold increase in genome-editing bioenterprise investment over the last year. This entrepreneurial movement has spurred a global biotechnology revolution in the realization of novel gene-editing technologies. This global shift in bioenterprise will continue to grow as the demand for personalized medicine, genetically modified crops and environmentally sustainable biofuels increases. However, the monopolization of intellectual property, negative public perception of genetic engineering and ambiguous regulatory policies may limit the growth of these market segments.

  17. Genome editing with engineered nucleases in plants.

    Science.gov (United States)

    Osakabe, Yuriko; Osakabe, Keishi

    2015-03-01

    Numerous examples of successful 'genome editing' now exist. Genome editing uses engineered nucleases as powerful tools to target specific DNA sequences to edit genes precisely in the genomes of both model and crop plants, as well as a variety of other organisms. The DNA-binding domains of zinc finger (ZF) proteins were the first to be used as genome editing tools, in the form of designed ZF nucleases (ZFNs). More recently, transcription activator-like effector nucleases (TALENs), as well as the clustered regularly interspaced short palindromic repeats/Cas9 (CRISPR/Cas9) system, which utilizes RNA-DNA interactions, have proved useful. A key step in genome editing is the generation of a double-stranded DNA break that is specific to the target gene. This is achieved by custom-designed endonucleases, which enable site-directed mutagenesis via a non-homologous end-joining (NHEJ) repair pathway and/or gene targeting via homologous recombination (HR) to occur efficiently at specific sites in the genome. This review provides an overview of recent advances in genome editing technologies in plants, and discusses how these can provide insights into current plant molecular biology research and molecular breeding technology.

  18. Genome editing systems in novel therapies.

    Science.gov (United States)

    Jang, Yoon-Young; Cai, Liuhong; Ye, Zhaohui

    2016-01-01

    Genome editing is the process in which DNA sequences at precise genomic locations are modified. In the past three decades, genome editing by homologous recombination has been successfully performed in mouse for generating genetic models. The low efficiency of this process in human cells, however, had prevented its clinical application until the recent advancements in designer endonuclease technologies. The significantly improved genome editing efficiencies aided by ZFN, TALEN, and CRISPR systems provide unprecedented opportunities not only for biomedical research, but also for developing novel therapies. Applications based on these genome editing tools to disrupt deleterious genes, correct genetic mutations, deliver functional transgenes more effectively or even modify the epigenetic landscape are being actively investigated for gene and cell therapy purposes. Encouraging results have been obtained in limited clinical trials in the past two years. While most of the applications are still in proof-of-principle or preclinical development stages, it is anticipated that the coming years will see increasing clinical success in novel therapies based on the modern genome editing technologies. It should be noted that critical issues still remain before the technologies can be translated into more reliable therapies. These key issues include off-target evaluation, establishing appropriate preclinical models and improving the currently low efficiency of homology-based precise gene replacement. In this review we discuss the preclinical and clinical studies aiming at translating the genome editing technologies as well as the issues that are important for more successful translation.

  19. A single alteration 20 nt 5′ to an editing target inhibits chloroplast RNA editing in vivo

    OpenAIRE

    2001-01-01

    Transcripts of typical dicot plant plastid genes undergo C→U RNA editing at approximately 30 locations, but there is no consensus sequence surrounding the C targets of editing. The cis-acting elements required for editing of the C located at tobacco rpoB editing site II were investigated by introducing translatable chimeric minigenes containing sequence –20 to +6 surrounding the C target of editing. When the –20 to +6 sequence specified by the homologous region pre...

  20. Differences between first and fourth year medical students' interest in pursuing careers in academic medicine.

    Science.gov (United States)

    Vetter, Monica H; Carter, Mary

    2016-05-24

    The purpose of this pilot study was to assess the differences in the attitudes of first and fourth-year medical students regarding careers in academics. We also sought to identify any factors associated with an increased interest in academic medicine. A cross-sectional study was conducted during October 2013 at the University of Louisville. All first and fourth year medical students were invited to complete an online survey utilizing a survey instrument developed through literature review. Demographic data and information about background experiences were collected in addition to participants' perceptions regarding careers in academia using a 5-point Likert scale. Participants were also queried about their current interest in a career in academics and the likelihood they would pursue academic medicine. Of the 330 potential participants, 140 (42.4%) agreed to participate. Overall, fourth-years reported a higher likelihood of pursuing an academic career than first-years. Research experience, publications, distinction track interest or involvement, and belief that a career in academics would reduce salary potential were positively correlated with reported likelihood of pursuing academic medicine. Findings from this pilot study demonstrate differences in interest in academic medicine between junior and senior medical students. Additionally, several factors were associated with a high likelihood of self-reported interest in academic. Based on these findings, efforts to increase medical students' interest in academic medicine careers could be supported by providing more research and teaching opportunities or distinction track options as a structured part of the medical school curriculum.

  1. Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems.

    Directory of Open Access Journals (Sweden)

    Pawel Bialk

    Full Text Available Single-stranded DNA oligonucleotides (ssODNs can direct the repair of a single base mutation in human genes. While the regulation of this gene editing reaction has been partially elucidated, the low frequency with which repair occurs has hampered development toward clinical application. In this work a CRISPR/Cas9 complex is employed to induce double strand DNA breakage at specific sites surrounding the nucleotide designated for exchange. The result is a significant elevation in ssODN-directed gene repair, validated by a phenotypic readout. By analysing reaction parameters, we have uncovered restrictions on gene editing activity involving CRISPR/Cas9 complexes. First, ssODNs that hybridize to the non-transcribed strand direct a higher level of gene repair than those that hybridize to the transcribed strand. Second, cleavage must be proximal to the targeted mutant base to enable higher levels of gene editing. Third, DNA cleavage enables a higher level of gene editing activity as compared to single-stranded DNA nicks, created by modified Cas9 (Nickases. Fourth, we calculated the hybridization potential and free energy levels of ssODNs that are complementary to the guide RNA sequences of CRISPRs used in this study. We find a correlation between free energy potential and the capacity of single-stranded oligonucleotides to inhibit specific DNA cleavage activity, thereby indirectly reducing gene editing activity. Our data provide novel information that might be taken into consideration in the design and usage of CRISPR/Cas9 systems with ssODNs for gene editing.

  2. Book Review: New Perspectives on Technical Editing

    Science.gov (United States)

    Murphy, A. J. (Ed.); Sterken, Christiaan

    2012-08-01

    New Perspectives on Technical Editing by Avon J. Murphy (ed.) ISBN : 978-0895033949 (2010) Baywood Publishing Company Inc, Hardcover, 210 pages, 35.5 GBP This book presents a collection of 10 chapters dealing with diverse aspects of technical editing (ie, editorial planning, and analysis and structural changes made to other people's technological documents): research in technical editing, trends and teaching of technical editing, copyediting, and technical journal editing. The role and function of the modern journal and book editor is also dealt with in detail. Each chapter is written by an expert in the field: senior editors, university professors in technical communication, technical writers and linguists. The ever-evolving role of the editor is clearly elucidated in several historical reviews, and in the descriptions of the expectations for the future. A very striking aspect of this book is its extensive collection of bibliographic resources: every chapter lists dozens of very useful references, and the closing chapter, and annotated bibliography, contain many not so well known references, and are most useful. All in all, the book is a treasure trove listing more than 400 references, in addition to numerous webpage URLs embedded in the texts. The book is designed to help the reader to understand current practices and norms in technical editing, and to help to take action in editing as well as in teaching and educating would-be editors. The audience for this book thus includes editors and teachers, but also writers, researchers and students. A deep reading of this book will result in a better understanding of the difference between full technical editing and its much narrower component so well known as copyediting, and will convince any prospective editor that editing should not be undertaken if the people involved do not master the art of precision and accuracy in technical (as well as in human) communication, do not possess the technical know how and computer

  3. Transportation Energy Data Book: Edition 14

    Energy Technology Data Exchange (ETDEWEB)

    Davis, S.C.

    1994-05-01

    Designed for use as a desk-top reference, the data book represents an assembly and display of statistics and information that characterize transportation activity, and presents data on other factors that influence transportation energy use. The purpose of this document is to present relevant statistical data in the form of tables and graphs. Each of the major transportation modes is treated in separate chapters or sections. Chapter 1 compares US transportation data with data from other countries. Aggregate energy use and energy supply data for all modes are presented in Chapter 2. The highway mode, which accounts for over three-fourths of total transportation energy consumption, is dealt with in Chapter 3. Topics in this chapter include automobiles, trucks, buses, fleet vehicles, federal standards, fuel economies, and high-occupancy vehicle lane data. Household travel behavior characteristics are displayed in Chapter 4. Chapter 5 contains information on alternative fuels and alternatively-fueled vehicles. Chapter 6 covers the major nonhighway modes: air, water, and rail. The last chapter, Chapter 7, presents data environmental issues relating to transportation.

  4. Progress in International Reading Literacy Study 2006 (PIRLS): Pedagogical Correlates of Fourth-Grade Students in Hong Kong

    Science.gov (United States)

    Cheung, Wai Ming; Tse, Shek Kam; Lam, Joseph W. I.; Ka Yee Loh, Elizabeth

    2009-01-01

    Reading literacy of fourth-grade students in Hong Kong showed a remarkable improvement from 2001 to 2006 as shown by international PIRLS studies. This study identified various aspects of the teacher factor contributing to the significant improvement among students. A total of 4,712 students and 144 teachers from 144 schools were randomly selected…

  5. Learn Sparse Dictionaries for Edit Propagation.

    Science.gov (United States)

    Xiaowu Chen; Jianwei Li; Dongqing Zou; Qinping Zhao

    2016-04-01

    With the increasing availability of high-resolution images, videos, and 3D models, the demand for scalable large data processing techniques increases. We introduce a method of sparse dictionary learning for edit propagation of large input data. Previous approaches for edit propagation typically employ a global optimization over the whole set of pixels (or vertexes), incurring a prohibitively high memory and time-consumption for large input data. Rather than propagating an edit pixel by pixel, we follow the principle of sparse representation to obtain a representative and compact dictionary and perform edit propagation on the dictionary instead. The sparse dictionary provides an intrinsic basis for input data, and the coding coefficients capture the linear relationship between all pixels and the dictionary atoms. The learned dictionary is then optimized by a novel scheme, which maximizes the Kullback-Leibler divergence between each atom pair to remove redundant atoms. To enable local edit propagation for images or videos with similar appearance, a dictionary learning strategy is proposed by considering range constraint to better account for the global distribution of pixels in their feature space. We show several applications of the sparsity-based edit propagation, including video recoloring, theme editing, and seamless cloning, operating on both color and texture features. Our approach can also be applied to computer graphics tasks, such as 3D surface deformation. We demonstrate that with an atom-to-pixel ratio in the order of 0.01% signifying a significant reduction on memory consumption, our method still maintains a high degree of visual fidelity.

  6. Pain management standards in the eighth edition of the Guide for the Care and Use of Laboratory Animals.

    Science.gov (United States)

    Carbone, Larry

    2012-05-01

    The eighth edition Guide for the Care and Use of Laboratory Animals sets standards for diverse laboratory animal care and use practices. It frames its standards as performance, engineering, and practice standards, with a strong emphasis on performance standards, allowing for multiple routes to clearly defined outcomes. Standards intended to be upheld rigorously are indicated through the use of must in the description, and those accommodating more flexibility are indicated through may and should statements. With respect to pain management standards, a fourth type of standard-the jurisdictional standard-has been prevalent through all 8 editions of the Guide. Under jurisdictional standards, specific methods and outcomes for measuring, preventing, or alleviating pain are not detailed, but the various jurisdictions of veterinarian, investigator, and IACUC are elaborated. Although data on pain management in laboratory animals has expanded greatly since the 1996 Guide, the eighth (2011) edition does not contain major new standards or guidance regarding animal pain management. Requirements for veterinary and IACUC involvement remain as in prior editions, and the duty of veterinarians and scientists to stay abreast of new developments is expected to drive refinement of animal pain management institution by institution. The current article details selected specific pain management standards in the 2011 Guide, lists topics in pain management for which the Guide does not set clear standards, and suggests possible standards for those topics.

  7. Older people and digital disengagement: a fourth digital divide?

    Science.gov (United States)

    Olphert, Wendy; Damodaran, Leela

    2013-01-01

    Digital technologies are becoming more pervasive in all areas of society. Enabling everyone to have access and capability to use the Internet and associated digital technologies, summed up in the term 'digital inclusion', is seen to have wide-ranging benefits to the individual, to the economy and to society. For older people, being digitally included can help them to maintain their independence, social connectedness and sense of worth in the face of declining health or limited capabilities, as well as also offering new opportunities to improve their quality of life. At present however, access to the technology and to the benefits is not equally distributed either between or within nations, and older people tend to be on the 'wrong' side of what is termed the 'digital divide'. Governments globally are developing strategies to promote digital inclusion and indeed Internet uptake is increasing steadily, including amongst older people. However, such strategies have focussed on getting people online, and there appears to be an assumption that once someone is online they will remain 'digitally engaged'. In fact statistics show that some users give up using the Internet, and there is emerging evidence that older people are more vulnerable to the factors which can lead to this outcome. The authors see this phenomenon as a potential but largely unrecognised 'fourth digital divide' which has serious implications for social inclusion. The objectives of this article are (a) to raise awareness of the phenomenon of digital disengagement by considering some of the emerging evidence, (b) to explore some of the potential implications of not recognising and therefore not addressing the needs of the digitally disengaged older population, and (c) to reveal the prevailing gap in knowledge which future research should address.

  8. Dark Coulomb binding of heavy neutrinos of fourth family

    Science.gov (United States)

    Belotsky, K. M.; Esipova, E. A.; Khlopov, M. Yu.; Laletin, M. N.

    2015-11-01

    Direct dark matter searches put severe constraints on the weakly interacting massive particles (WIMPs). These constraints cause serious troubles for the model of stable neutrino of fourth generation with mass around 50GeV. Though the calculations of primordial abundance of these particles make them in the charge symmetric case a sparse subdominant component of the modern dark matter, their presence in the universe would exceed the current upper limits by several orders of the magnitude. However, if quarks and leptons of fourth generation possess their own Coulomb-like y-interaction, recombination of pairs of heavy neutrinos and antineutrinos and their annihilation in the “neutrinium” atoms can play important role in their cosmological evolution, reducing their modern abundance far below the experimental upper limits. The model of stable fourth generation assumes that the dominant part of dark matter is explained by excessive Ū antiquarks, forming (ŪŪŪ)-- charged clusters, bound with primordial helium in nuclear-interacting O-helium (OHe) dark atoms. The y charge conservation implies generation of the same excess of fourth generation neutrinos, potentially dangerous WIMP component of this scenario. We show that due to y-interaction recombination of fourth neutrinos with OHe hides these WIMPs from direct WIMP searches, leaving the negligible fraction of free neutrinos, what makes their existence compatible with the experimental constraints.

  9. Review of "Handbook of Human Factors in Medical Device Design", edited by Matthew B. Weinger, Michael E. Wiklund and Daryle J. Gardner-Bonneau, Assistant Editor Loir M. Kelly

    Directory of Open Access Journals (Sweden)

    Gaev Jonathan A

    2011-06-01

    Full Text Available Abstract Human factors is the study of the relationship between people and devices or systems. The goal of considering human factors in the design of medical devices is to create devices that take into consideration the way people use technology and process information to create a man-machine interface that leads to the best possible performance. This text describes the significant aspects of human factors issues related to medical device design. It is well written and is useful for medical device designers and for others who use or evaluate medical equipment.

  10. Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis.

    Directory of Open Access Journals (Sweden)

    Jean-Pierre Vartanian

    2010-05-01

    Full Text Available DNA viruses, retroviruses and hepadnaviruses, such as hepatitis B virus (HBV, are vulnerable to genetic editing of single stranded DNA by host cell APOBEC3 (A3 cytidine deaminases. At least three A3 genes are up regulated by interferon-alpha in human hepatocytes while ectopic expression of activation induced deaminase (AICDA, an A3 paralog, has been noted in a variety of chronic inflammatory syndromes including hepatitis C virus infection. Yet virtually all studies of HBV editing have confined themselves to analyses of virions from culture supernatants or serum where the frequency of edited genomes is generally low (HBV>alcoholic cirrhosis. A3C and A3D were up regulated for all groups while the interferon inducible A3G was over expressed in virus associated cirrhosis, as was AICDA in approximately 50% of these HBV/HCV samples. While AICDA can indeed edit HBV DNA ex vivo, A3G is the dominant deaminase in vivo with up to 35% of HBV genomes being edited. Despite these highly deleterious mutant spectra, a small fraction of genomes survive and contribute to loss of HBeAg antigenemia and possibly HBsAg immune escape. In conclusion, the cytokine storm associated with chronic inflammatory responses to HBV and HCV clearly up regulates a number of A3 genes with A3G clearly being a major restriction factor for HBV. Although the mutant spectrum resulting from A3 editing is highly deleterious, a very small part, notably the lightly edited genomes, might help the virus evolve and even escape immune responses.

  11. Results of the fourth Hanna field test

    Energy Technology Data Exchange (ETDEWEB)

    Covell, J. R.; Wojdac, L. F.; Barbour, F. A.; Gardner, G. W.; Glass, R.; Hommert, P. J.

    1980-01-01

    The second phase (Hanna IVB) of a coal gasification experiment near Hanna, Wyoming, was completed in September 1979. The experiment attempted to link and gasify coal between process wells spaced 34.3 meters apart. Intermediate wells were positioned between the process wells so that the link could be relayed over shorter distances. Reverse combustion linking was attempted over a 22.9-meter and a 11.4-meter distance of the total well spacing. Thermal activity was generally noted in the upper 3 meters of the coal seam during the link. Two attempts to gasify over the 34.3-meter distance resulted in the propagation of the burn front at the coal overburden interface. Post-burn evaluation indicates fractures as major influencing factors of the combustion process. The Hanna IVB field test provided much insight into influence that geologic features have on in situ coal combustion. The influence of these faults, permeable zones, and cleats, on the air flow patterns can drastically change the overall results of a gasification experiment and should be studied further. The overall results of Hanna IVB were discouraging because of the rapid decline in the heating values for the production gas and the amount of coal gasified. With more complete geologic characerization prior to experimentation and proper well completions, it is believed that most of the subsurface operational problems encountered during Hanna IV could have been avoided.

  12. Two New Fourth-Order Three-Stage Symplectic Integrators

    Institute of Scientific and Technical Information of China (English)

    LI Rong; WU Xin

    2011-01-01

    Two new fourth-order three-stage symplectic integrators are specifically designed for a family of Hamiltonian systems,such as the harmonic oscillator,mathematical pendulum and lattice ψ4 model.When the nonintegrable lattice ψ4 system is taken as a test model,numerical comparisons show that the new methods have a great advantage over the second-order Verlet symplectic integrators in the accuracy of energy,become explicitly better than the usual non-gradient fourth-order seven-stage symplectic integrator of Forest and Ruth,and are almost equivalent to a fourth-order seven-stage force gradient symplectic integrator of Chin.As the most important advantage,the new integrators are convenient for solving the variational equations of many Hamiltonian systems so as to save a great deal of the computational cost when scanning a lot of orbits for chaos.

  13. Scaling, similarity, and the fourth paradigm for hydrology

    Science.gov (United States)

    Peters-Lidard, Christa D.; Clark, Martyn; Samaniego, Luis; Verhoest, Niko E. C.; van Emmerik, Tim; Uijlenhoet, Remko; Achieng, Kevin; Franz, Trenton E.; Woods, Ross

    2017-07-01

    In this synthesis paper addressing hydrologic scaling and similarity, we posit that roadblocks in the search for universal laws of hydrology are hindered by our focus on computational simulation (the third paradigm) and assert that it is time for hydrology to embrace a fourth paradigm of data-intensive science. Advances in information-based hydrologic science, coupled with an explosion of hydrologic data and advances in parameter estimation and modeling, have laid the foundation for a data-driven framework for scrutinizing hydrological scaling and similarity hypotheses. We summarize important scaling and similarity concepts (hypotheses) that require testing; describe a mutual information framework for testing these hypotheses; describe boundary condition, state, flux, and parameter data requirements across scales to support testing these hypotheses; and discuss some challenges to overcome while pursuing the fourth hydrological paradigm. We call upon the hydrologic sciences community to develop a focused effort towards adopting the fourth paradigm and apply this to outstanding challenges in scaling and similarity.

  14. The fourth Arab Impact Cratering and Astrogeology Conference (AICAC IV), April 9-12, 2017, Algiers (Algeria)

    Science.gov (United States)

    Belhaï, D.; Chennaoui-Aoudjehane, H.; Baratoux, D.; Ferrière, L.; Lamali, A.; Sahoui, R.; Lambert, P.; Ayadi, A.

    2017-09-01

    We present a report about the fourth Arab Impact Cratering and Astrogeology Conference (AICAC IV) that took place in Algiers at the USTHB (Université des Sciences et Technologie Houari Boumedienne, Algiers, Algeria) in the presence of the presidents of the USTHB and Boumerdès Universities, the Director of CRAAG (Centre de Recherche en Astronomie, Astrophysique et Géophysique), and the General Director of the National Administration for Scientific Research (NASR/DGRSDT). This series of conferences aims to promote research interest for impact cratering in the Arab world and beyond, including for instance in African countries. In spite of persistently restraining travel measures to Algeria, the fourth edition held in Algiers was marked by continuous international participation, with participants from seven different countries. This conference focused on presentations of scientific results in the research fields related to planetology, meteorites, and impact craters. In particular, the Algerian impact structures were under the spotlights during both oral and poster sessions. During this conference, the presence of freshly graduated Ph.D. students and new Ph.D. projects related to impact cratering or meteoritic science was a positive sign for the consolidation of research groups in this domain in the Arab world and Africa. Therefore, international cooperation or external support and funding are still needed to ensure the development of this scientific discipline in this part of the world.

  15. Designed nucleases for targeted genome editing.

    Science.gov (United States)

    Lee, Junwon; Chung, Jae-Hee; Kim, Ho Min; Kim, Dong-Wook; Kim, Hyongbum

    2016-02-01

    Targeted genome-editing technology using designed nucleases has been evolving rapidly, and its applications are widely expanding in research, medicine and biotechnology. Using this genome-modifying technology, researchers can precisely and efficiently insert, remove or change specific sequences in various cultured cells, micro-organisms, animals and plants. This genome editing is based on the generation of double-strand breaks (DSBs), repair of which modifies the genome through nonhomologous end-joining (NHEJ) or homology-directed repair (HDR). In addition, designed nickase-induced generation of single-strand breaks can also lead to precise genome editing through HDR, albeit at relatively lower efficiencies than that induced by nucleases. Three kinds of designed nucleases have been used for targeted DSB formation: zinc-finger nucleases, transcription activator-like effector nucleases, and RNA-guided engineered nucleases derived from the bacterial clustered regularly interspaced short palindromic repeat (CRISPR)-Cas (CRISPR-associated) system. A growing number of researchers are using genome-editing technologies, which have become more accessible and affordable since the discovery and adaptation of CRISPR-Cas9. Here, the repair mechanism and outcomes of DSBs are reviewed and the three types of designed nucleases are discussed with the hope that such understanding will facilitate applications to genome editing.

  16. BOOK REVIEW: Quantum Gravity: third edition Quantum Gravity: third edition

    Science.gov (United States)

    Rovelli, Carlo

    2012-09-01

    The request by Classical and Quantum Gravity to review the third edition of Claus Kiefer's 'Quantum Gravity' puts me in a slightly awkward position. This is a remarkably good book, which every person working in quantum gravity should have on the shelf. But in my opinion quantum gravity has undergone some dramatic advances in the last few years, of which the book makes no mention. Perhaps the omission only attests to the current vitality of the field, where progress is happening fast, but it is strange for me to review a thoughtful, knowledgeable and comprehensive book on my own field of research, which ignores what I myself consider the most interesting results to date. Kiefer's book is unique as a broad introduction and a reliable overview of quantum gravity. There are numerous books in the field which (often notwithstanding titles) focus on a single approach. There are also countless conference proceedings and article collections aiming to be encyclopaedic, but offering disorganized patchworks. Kiefer's book is a careful and thoughtful presentation of all aspects of the immense problem of quantum gravity. Kiefer is very learned, and brings together three rare qualities: he is pedagogical, he is capable of simplifying matter to the bones and capturing the essential, and he offers a serious and balanced evaluation of views and ideas. In a fractured field based on a major problem that does not yet have a solution, these qualities are precious. I recommend Kiefer's book to my students entering the field: to work in quantum gravity one needs a vast amount of technical knowledge as well as a grasp of different ideas, and Kiefer's book offers this with remarkable clarity. This novel third edition simplifies and improves the presentation of several topics, but also adds very valuable new material on quantum gravity phenomenology, loop quantum cosmology, asymptotic safety, Horava-Lifshitz gravity, analogue gravity, the holographic principle, and more. This is a testament

  17. Investigating the Theoretical Structure of the Stanford-Binet-Fifth Edition

    Science.gov (United States)

    DiStefano, Christine; Dombrowski, Stefan C.

    2006-01-01

    The fifth edition of the Stanford-Binet test went through significant reformulation of its item content, administration format, standardization procedures, and theoretical structure. Additionally, the test was revised to measure five factors important to intelligence across both verbal and nonverbal domains. To better understand these substantial…

  18. Technical Analysis of the Disruptive Behavior Rating Scale--Second Edition--Teacher Version

    Science.gov (United States)

    Erford, Bradley T.; Clark, Kelly

    2011-01-01

    The reliability and validity of scores on the Disruptive Behavior Rating Scale-second edition-teacher version (DBRS-II-T) was analyzed. The DBRS-II-T was designed to assess teacher observations of students referred for behavioral difficulties. The five-factor model fit the data poorly, but convergent and diagnostic validities were excellent.…

  19. Meta-Analysis of the English Version of the Beck Depression Inventory-Second Edition

    Science.gov (United States)

    Erford, Bradley T.; Johnson, Erin; Bardoshi, Gerta

    2016-01-01

    This meta-analysis reviewed 144 studies from 1996 to 2013 using the Beck Depression Inventory-Second Edition. Internal consistency was 0.89 and test-retest reliability 0.75. Convergent comparisons were robust across 43 depression instruments. Structural validity supported both one- and two-factor solutions and diagnostic accuracy varied according…

  20. Technical Analysis of the Disruptive Behavior Rating Scale--Second Edition--Teacher Version

    Science.gov (United States)

    Erford, Bradley T.; Clark, Kelly

    2011-01-01

    The reliability and validity of scores on the Disruptive Behavior Rating Scale-second edition-teacher version (DBRS-II-T) was analyzed. The DBRS-II-T was designed to assess teacher observations of students referred for behavioral difficulties. The five-factor model fit the data poorly, but convergent and diagnostic validities were excellent.…

  1. Towards Reviving Electroweak Baryogenesis with a Fourth Generation

    Directory of Open Access Journals (Sweden)

    Wei-Shu Hou

    2013-01-01

    universe. However, it does not work within the standard model due to two reasons: (1 the strength of CP violation from the Kobayashi-Maskawa mechanism with three generations is too small; (2 the electroweak phase transition is not first order for the experimentally allowed Higgs boson mass. We discuss possibilities to solve these problems by introducing a fourth generation of fermions and how electroweak baryogenesis might be revived. We also discuss briefly the recent observation of a Higgs-like boson with mass around 125 GeV, which puts the fourth generation in a difficult situation, and the possible way out.

  2. Bergman kernel function on Hua construction of the fourth type

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    This paper introduces the Hua construction and presents the holomorphic automorphism group of the Hua construction of the fourth type. Utilizing the Bergman kernel function, under the condition of holomorphic automorphism and the standard complete orthonormal system of the semi-Reinhardt domain, the infinite series form of the Bergman kernel function is derived. By applying the properties of polynomial and Γ functions, various identification relations of the aforementioned form are developed and the explicit formula of the Bergman kernel function for the Hua construction of the fourth type is obtained, which suggest that many of the previously-reported results are only the special cases of our findings.

  3. Introduction to nuclear science, second edition

    CERN Document Server

    Bryan, Jeff C.

    2013-01-01

    This book was written to provide students who have limited backgrounds in the physical sciences and math with an accessible textbook on nuclear science. Expanding on the foundation of the bestselling first edition, Introduction to Nuclear Science, Second Edition provides a clear and complete introduction to nuclear chemistry and physics, from basic concepts to nuclear power and medical applications. Incorporating suggestions from professors using this book for their courses, the author has created a new text that is approximately 60 percent larger and more comprehensive and flexible than the first.New to This Edition: Thorough review of nuclear forensics, radiology, gamma cameras, and decay through proton or neutron emission More detailed explanations of the necessary mathematics A chapter on dosimetry of radiation fields Expanded discussion of applications, introduced earlier in the text More in-depth coverage of nuclear reactors, including a new chapter examining more reactor types, their safety systems,...

  4. Edit Propagation via Edge-Aware Filtering

    Institute of Scientific and Technical Information of China (English)

    Wei Hu; Zhao Dong; Guo-Dong Yuan

    2012-01-01

    This paper presents a novel framework for efficiently propagating the stroke-based user edits to the regions with similar colors and locations in high resolution images and videos.Our framework is based on the key observation that the edit propagation intrinsically can also be achieved by utilizing recently proposed edge-preserving filters.Therefore,instead of adopting the traditional global optimization which may involve a time-consuming solution,our algorithm propagates edits with the aid of the edge-preserve filters.Such a propagation scheme has low computational complexity and supports multiple kinds of strokes for more flexible user interactions.Further,our method can be easily and efficiently implemented in GPU.The experimental results demonstrate the efficiency and user-friendliness of our approach.

  5. Gauge Field Theories, 2nd Edition

    Science.gov (United States)

    Frampton, Paul H.

    2000-08-01

    The first edition of Gauge Field Theories, published in 1985, quickly became widely used in universities and other institutions of higher learning around the world. Written by well-known physicist Paul Frampton, the new edition continues to offer a first-rate mathematical treatment of gauge field theories, while thoroughly updating all chapters to keep pace with developments in the field. Frampton emphasizes formalism rather than experiments and provides sufficient detail for readers wishing to do their own calculations or pursue theoretical physics research. Special features of the Second Edition include: * Improved, logical organization of the material on gauge invariance, quantization, and renormalization * Major revision of the chapter on electroweak interactions, incorporating the latest precision data and discovery of the top quark * Discussions of renormalization group and quantum chromodynamics * A completely new chapter on model building

  6. Ethical and regulatory aspects of genome editing.

    Science.gov (United States)

    Kohn, Donald B; Porteus, Matthew H; Scharenberg, Andrew M

    2016-05-26

    Gene editing is a rapidly developing area of biotechnology in which the nucleotide sequence of the genome of living cells is precisely changed. The use of genome-editing technologies to modify various types of blood cells, including hematopoietic stem cells, has emerged as an important field of therapeutic development for hematopoietic disease. Although these technologies offer the potential for generation of transformative therapies for patients suffering from myriad disorders of hematopoiesis, their application for therapeutic modification of primary human cells is still in its infancy. Consequently, development of ethical and regulatory frameworks that ensure their safe and effective use is an increasingly important consideration. Here, we review a number of issues that have the potential to impact the clinical implementation of genome-editing technologies, and suggest paths forward for resolving them such that new therapies can be safely and rapidly translated to the clinic. © 2016 by The American Society of Hematology.

  7. A-to-I RNA editing: the "ADAR" side of human cancer.

    Science.gov (United States)

    Galeano, Federica; Tomaselli, Sara; Locatelli, Franco; Gallo, Angela

    2012-05-01

    Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human diseases, including tumours. A-to-I RNA editing changes the nucleotide sequence of target RNAs, introducing A-to-I/G "mutations". Since ADAR enzymes catalyse this nucleotide conversion, their expression/activity is essential and finely regulated in normal cells. This review summarizes the available knowledge on A-to-I RNA editing in the cancer field, giving a new view on how ADARs may play a role in carcinogenesis.

  8. Linguistic neighbourhoods: explaining cultural borders on Wikipedia through multilingual co-editing activity

    CERN Document Server

    Samoilenko, Anna; Edler, Daniel; Kunegis, Jérôme; Strohmaier, Markus

    2016-01-01

    In this paper, we study the network of global interconnections between language communities, based on shared co-editing interests of Wikipedia editors, and show that although English is discussed as a potential lingua franca of the digital space, its domination disappears in the network of co-editing similarities, and instead local connections come to the forefront. Out of the hypotheses we explored, bilingualism, linguistic similarity of languages, and shared religion provide the best explanations for the similarity of interests between cultural communities. Population attraction and geographical proximity are also significant, but much weaker factors bringing communities together. In addition, we present an approach that allows for extracting significant cultural borders from editing activity of Wikipedia users, and comparing a set of hypotheses about the social mechanisms generating these borders. Our study sheds light on how culture is reflected in the collective process of archiving knowledge on Wikipedi...

  9. Targeted Editing of Myostatin Gene in Sheep by Transcription Activator-like Effector Nucleases.

    Science.gov (United States)

    Zhao, Xinxia; Ni, Wei; Chen, Chuangfu; Sai, Wujiafu; Qiao, Jun; Sheng, Jingliang; Zhang, Hui; Li, Guozhong; Wang, Dawei; Hu, Shengwei

    2016-03-01

    Myostatin (MSTN) is a secreted growth factor expressed in skeletal muscle and adipose tissue that negatively regulates skeletal muscle mass. Gene knockout of MSTN can result in increasing muscle mass in sheep. The objectives were to investigate whether myostatin gene can be edited in sheep by transcription activator-like effector nucleases (TALENs) in tandem with single-stranded DNA oligonucleotides (ssODNs). We designed a pair of TALENs to target a highly conserved sequence in the coding region of the sheep MSTN gene. The activity of the TALENs was verified by using luciferase single-strand annealing reporter assay in HEK 293T cell line. Co-transfection of TALENs and ssODNs oligonucleotides induced precise gene editing of myostatin gene in sheep primary fibroblasts. MSTN gene-edited cells were successfully used as nuclear donors for generating cloned embryos. TALENs combined with ssDNA oligonucleotides provide a useful approach for precise gene modification in livestock animals.

  10. Ethics of using language editing services in an era of digital communication and heavily multiauthored papers

    CERN Document Server

    Lozano, George A

    2013-01-01

    Scientists of many countries in which English is not the primary language routinely use a variety of manuscript preparation, correction or editing services, a practice that is openly endorsed by many journals and scientific institutions. These services vary tremendously in their scope; at one end there is simple proof-reading, and at the other extreme there is in-depth and extensive peer-reviewing, proposal preparation, statistical analyses, re-writing and co-writing. In this paper, the various types of service are reviewed, along with authorship guidelines, and the question is raised of whether the high-end services surpass most guidelines' criteria for authorship. Three other factors are considered. First, the ease of collaboration possible in the internet era allows multiple iterations between authors and the editing service, so essentially, papers can be co-written. Second, 'editing services' often offer subject-specific experts who comment not only on the language, but interpret and improve scientific co...

  11. CRISPR/Cas9 Platforms for Genome Editing in Plants: Developments and Applications.

    Science.gov (United States)

    Ma, Xingliang; Zhu, Qinlong; Chen, Yuanling; Liu, Yao-Guang

    2016-07-06

    The clustered regularly interspaced short palindromic repeat (CRISPR)-associated protein9 (Cas9) genome editing system (CRISPR/Cas9) is adapted from the prokaryotic type II adaptive immunity system. The CRISPR/Cas9 tool surpasses other programmable nucleases, such as ZFNs and TALENs, for its simplicity and high efficiency. Various plant-specific CRISPR/Cas9 vector systems have been established for adaption of this technology to many plant species. In this review, we present an overview of current advances on applications of this technology in plants, emphasizing general considerations for establishment of CRISPR/Cas9 vector platforms, strategies for multiplex editing, methods for analyzing the induced mutations, factors affecting editing efficiency and specificity, and features of the induced mutations and applications of the CRISPR/Cas9 system in plants. In addition, we provide a perspective on the challenges of CRISPR/Cas9 technology and its significance for basic plant research and crop genetic improvement.

  12. Quantum Field Theory, Revised Edition

    Science.gov (United States)

    Mandl, F.; Shaw, G.

    1994-01-01

    Quantum Field Theory Revised Edition F. Mandl and G. Shaw, Department of Theoretical Physics, The Schuster Laboratory, The University, Manchester, UK When this book first appeared in 1984, only a handful of W± and Z° bosons had been observed and the experimental investigation of high energy electro-weak interactions was in its infancy. Nowadays, W± bosons and especially Z° bosons can be produced by the thousand and the study of their properties is a precise science. We have revised the text of the later chapters to incorporate these developments and discuss their implications. We have also taken this opportunity to update the references throughout and to make some improvements in the treatment of dimen-sional regularization. Finally, we have corrected some minor errors and are grateful to various people for pointing these out. This book is designed as a short and simple introduction to quantum field theory for students beginning research in theoretical and experimental physics. The three main objectives are to explain the basic physics and formalism of quantum field theory, to make the reader fully proficient in theory calculations using Feynman diagrams, and to introduce the reader to gauge theories, which play such a central role in elementary particle physics. The theory is applied to quantum electrodynamics (QED), where quantum field theory had its early triumphs, and to weak interactions where the standard electro-weak theory has had many impressive successes. The treatment is based on the canonical quantization method, because readers will be familiar with this, because it brings out lucidly the connection between invariance and conservation laws, and because it leads directly to the Feynman diagram techniques which are so important in many branches of physics. In order to help inexperienced research students grasp the meaning of the theory and learn to handle it confidently, the mathematical formalism is developed from first principles, its physical

  13. RNA Editing and Drug Discovery for Cancer Therapy

    Directory of Open Access Journals (Sweden)

    Wei-Hsuan Huang

    2013-01-01

    Full Text Available RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. Therefore, RNA editing may be a potential target for therapeutic natural products. In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.

  14. Email English (2nd Edition) by Paul Emmerson

    OpenAIRE

    Simpson, Adam John

    2013-01-01

    A thoroughly worthwhile update to a classic book about emailing which retains everything that was right about the first edition while effectively revitalizing its content a decade on from the first edition.

  15. Unravelling the Franklin Mystery, Second Edition with David C. Woodman

    DEFF Research Database (Denmark)

    Burke, Danita Catherine

    2017-01-01

    This is a forthcoming book review of David C. Woodman's second edition of his book "Unravelling the Franklin Mystery."......This is a forthcoming book review of David C. Woodman's second edition of his book "Unravelling the Franklin Mystery."...

  16. Direct Visual Editing of Node Attributes in Graphs

    Directory of Open Access Journals (Sweden)

    Christian Eichner

    2016-10-01

    Full Text Available There are many expressive visualization techniques for analyzing graphs. Yet, there is only little research on how existing visual representations can be employed to support data editing. An increasingly relevant task when working with graphs is the editing of node attributes. We propose an integrated visualize-and-edit approach to editing attribute values via direct interaction with the visual representation. The visualize part is based on node-link diagrams paired with attribute-dependent layouts. The edit part is as easy as moving nodes via drag-and-drop gestures. We present dedicated interaction techniques for editing quantitative as well as qualitative attribute data values. The benefit of our novel integrated approach is that one can directly edit the data while the visualization constantly provides feedback on the implications of the data modifications. Preliminary user feedback indicates that our integrated approach can be a useful complement to standard non-visual editing via external tools.

  17. The art of editing RNA structural alignments

    DEFF Research Database (Denmark)

    Andersen, Ebbe Sloth

    2014-01-01

    Manual editing of RNA structural alignments may be considered more art than science, since it still requires an expert biologist to take multiple levels of information into account and be slightly creative when constructing high-quality alignments. Even though the task is rather tedious, it is re......Manual editing of RNA structural alignments may be considered more art than science, since it still requires an expert biologist to take multiple levels of information into account and be slightly creative when constructing high-quality alignments. Even though the task is rather tedious...

  18. The art of editing RNA structural alignments

    DEFF Research Database (Denmark)

    Andersen, Ebbe Sloth

    2014-01-01

    Manual editing of RNA structural alignments may be considered more art than science, since it still requires an expert biologist to take multiple levels of information into account and be slightly creative when constructing high-quality alignments. Even though the task is rather tedious, it is re......Manual editing of RNA structural alignments may be considered more art than science, since it still requires an expert biologist to take multiple levels of information into account and be slightly creative when constructing high-quality alignments. Even though the task is rather tedious...

  19. European Corporate Law, 2nd edition

    DEFF Research Database (Denmark)

    Werlauff, Erik; Dorresteijn, Adriaan; Monteiro, Tiago Pereira

    As in the First Edition (1995) of this well-known book, the authors demonstrate that analysis and comparison of national corporate laws on a number of issues yield highly valuable general principles and observations, not least because business organisations, wherever located, tend to show...... a fundamentally similar set of legal characteristics. To its original selection of six representative jurisdictions - Belgium, France, Germany, The Netherlands, Spain, and the United Kingdom - the Second Edition now adds Poland, thus including an Eastern European perspective to supplement those of continental...

  20. Prince2 2009 edition a pocket guide

    CERN Document Server

    Hedeman, Bert

    2010-01-01

    This Pocket Guide supplies a summary of the PRINCE2 method, to provide a quick introduction as well as a structured overview of the method;Main target Group for this pocket guide is anyone who wants to get to know the method PRINCE2 or a methodical approach for project management. The book is also very useful for members of a project management team on a project using the PRINCE2 method. Furthermore this pocket guide can be used as literature for the preparation of the PRINCE2 2009 Edition Foundation exam;This pocket guide is based on PRINCE2 2009 Edition;This pocket book deals with processes,