The economic and mathematical analysis of migration of employable population as a factor of national modernization in crisis

Directory of Open Access Journals (Sweden)

Liudmyla ANDROSHCHUK

2016-06-01

Full Text Available The methodical approach presented in the article allows for an unbiased analysis of the complex migratory processes that take place in Ukraine due to the influence of social, economic and financial indicators. The article offers a reliable analysis of the migratory processes, applying the differential logistic population model in order to clarify the effect of labour migration on the productive ability of the economy. The authors investigate the factors that induce a human person to migrate, and show that globalization affects international mobility.

Macrophage migration inhibitory factor is associated with aneurysmal expansion

DEFF Research Database (Denmark)

Pan, Jie-Hong; Lindholt, Jes Sanddal; Sukhova, Galina K

2003-01-01

Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine released mainly from macrophages and activated lymphocytes. Both atherosclerosis and abdominal aortic aneurysm (AAA) are inflammatory diseases tightly linked to the function of these cells. The correlation and contribution o...... of MIF to these human diseases remain unknown, although a recent rabbit study showed expression of this cytokine in atherosclerotic lesions.......Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine released mainly from macrophages and activated lymphocytes. Both atherosclerosis and abdominal aortic aneurysm (AAA) are inflammatory diseases tightly linked to the function of these cells. The correlation and contribution...

ANALYSIS OF POPULATION MIGRATION AS A CRIMINOGENIC FACTOR

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Mariana MITRA-NIŢĂ

2016-07-01

Full Text Available Migration is a voluntary movement of population from one geographic location to another. This movement can be of several types, depending on the cause determining the respective migration. Population movements or its mobility is not a new phenomenon but has deep roots in ancient history. We can even say that in the beginning man was migratory, nomadic and later it became steadfast, linked in some way to certain geographic locations. Population migration has multiple consequences, both positive and negative. Among the negative we can mention overpopulation or underpopulation of certain areas, heterogeneity of traditions and cultures of immigrants, inability of migratory population to adapt to the area they migrated to, not finding a job, marginalization, etc. All these are genuine and objective criminological factors that could actually cause committing crimes in the migratory population. We cannot and do not want to stop the mobility of people, but we can be careful to avoid harmful consequences caused by this phenomenon.

Risk factors for venous port migration in a single institute in Taiwan.

Science.gov (United States)

Fan, Wen-Chieh; Wu, Cheng-Han; Tsai, Ming-Ju; Tsai, Ying-Ming; Chang, Hsu-Liang; Hung, Jen-Yu; Chen, Pei-Huan; Yang, Chih-Jen

2014-01-14

An implantable port device provides an easily accessible central route for long-term chemotherapy. Venous catheter migration is one of the rare complications of venous port implantation. It can lead to side effects such as pain in the neck, shoulder, or ear, venous thrombosis, and even life-threatening neurologic problems. To date, there are few published studies that discuss such complications. This retrospective study of venous port implantation in a single center, a Taiwan hospital, was conducted from January 2011 to March 2013. Venous port migration was recorded along with demographic and characteristics of the patients. Of 298 patients with an implantable import device, venous port migration had occurred in seven, an incidence rate of 2.3%. All seven were male and had received the Bard port Fr 6.6 which had smaller size than TYCO port Fr 7.5 and is made of silicon. Significantly, migration occurred in male patients (P = 0.0006) and in those with lung cancer (P = 0.004). Multivariable logistic regression analysis revealed that lung cancer was a significant risk factor for port migration (odds ratio: 11.59; P = 0.0059). The migration rate of the Bard port Fr 6.6 was 6.7%. The median time between initial venous port implantation and port migration was 35.4 days (range, 7 to 135 days) and 71.4% (5/7) of patients had port migration within 30 days after initial port implantation. Male sex and lung cancer are risk factors for venous port migration. The type of venous port is also an important risk factor.

Macrophage migration inhibitory factor and autism spectrum disorders

NARCIS (Netherlands)

Grigorenko, Elena L.; Han, Summer S.; Yrigollen, Carolyn M.; Leng, Lin; Mizue, Yuka; Anderson, George M.; Mulder, Erik J.; de Bildt, Annelies; Minderaa, Ruud B.; Volkmar, Fred R.; Chang, Joseph T.; Bucala, Richard

OBJECTIVE. Autistic spectrum disorders are childhood neurodevelopmental disorders characterized by social and communicative impairment and repetitive and stereotypical behavior. Macrophage migration inhibitory factor (MIF) is an upstream regulator of innate immunity that promotes

The niche-derived glial cell line-derived neurotrophic factor (GDNF induces migration of mouse spermatogonial stem/progenitor cells.

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Lisa Dovere

Full Text Available In mammals, the biological activity of the stem/progenitor compartment sustains production of mature gametes through spermatogenesis. Spermatogonial stem cells and their progeny belong to the class of undifferentiated spermatogonia, a germ cell population found on the basal membrane of the seminiferous tubules. A large body of evidence has demonstrated that glial cell line-derived neurotrophic factor (GDNF, a Sertoli-derived factor, is essential for in vivo and in vitro stem cell self-renewal. However, the mechanisms underlying this activity are not completely understood. In this study, we show that GDNF induces dose-dependent directional migration of freshly selected undifferentiated spermatogonia, as well as germline stem cells in culture, using a Boyden chamber assay. GDNF-induced migration is dependent on the expression of the GDNF co-receptor GFRA1, as shown by migration assays performed on parental and GFRA1-transduced GC-1 spermatogonial cell lines. We found that the actin regulatory protein vasodilator-stimulated phosphoprotein (VASP is specifically expressed in undifferentiated spermatogonia. VASP belongs to the ENA/VASP family of proteins implicated in actin-dependent processes, such as fibroblast migration, axon guidance, and cell adhesion. In intact seminiferous tubules and germline stem cell cultures, GDNF treatment up-regulates VASP in a dose-dependent fashion. These data identify a novel role for the niche-derived factor GDNF, and they suggest that GDNF may impinge on the stem/progenitor compartment, affecting the actin cytoskeleton and cell migration.

Inter-communal migrations in Switzerland: a "mountain factor"?

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Martin Camenisch

2011-05-01

Full Text Available To go beyond existing publications on inter-communal migrations in Switzerland, this paper focuses on a comparison of behaviours between communes of different types: rural, urban, mountain, tourist, etc. It is based on two sets of data: the Swiss Population Census (1999-2008 and the Swiss Household Panel. This paper has two main conclusions of this paper: first, contrary to the dominant practice which compares communes according to their respective difference between in-migration and out-migration rate, this paper highlights the contrast between “warm” and “cold” communes (comparing the migration rate itself; there is a "mountain factor" which means that most inter-communal migrations occur within the mountain zone, or within the Swiss Plateau.Prolongeant les publications existantes sur les migrations intercommunales en Suisse, l'article focalise son attention sur les comportements différenciés des communes selon les types dont elles relèvent: urbaines, montagnardes, touristiques, rurales, etc. Il repose sur l'utilisation des données du recensement fédéral de la population (1999-2008 et sur celles du Panel Suisse des Ménages. Il parvient à deux conclusions principales: les communes que l'on compare le plus souvent en fonction de leur bilan migratoire, peuvent aussi être utilement différenciées selon qu'elles sont « chaudes » ou « froides » (avec un taux de migration fort ou faible, quelque soit le solde; il existe un "effet montagne" qui signifie ici la propension des migrations à se faire principalement à l'intérieur de la zone de montagne suisse ou à l'intérieur du Plateau suisse.

The incomplete trajectory of Albanian migration in Greece

OpenAIRE

GEMI, Eda

2015-01-01

Proceedings from the conference "Governing Irregular Migration : States, Actors and Intermediaries", Athens 8-9 July 2015 The study addresses the irregular migration of Albanians to Greece. In particular, it analyses the key findings of the fieldwork with 87 Albanian migrants, the dynamic of irregular migration from Albania to Greece, the factors and the actors who affect them as well as the success or failure of the relevant migration policies. The report shows that the expanding possibil...

Compulsory Schooling Laws and Migration Across European Countries.

Science.gov (United States)

Aparicio Fenoll, Ainhoa; Kuehn, Zoë

2017-12-01

Educational attainment is a key factor for understanding why some individuals migrate and others do not. Compulsory schooling laws, which determine an individual's minimum level of education, can potentially affect migration. We test whether and how increasing the length of compulsory schooling influences migration of affected cohorts across European countries, a context where labor mobility is essentially free. We construct a novel database that includes information for 31 European countries on compulsory education reforms passed between 1950 and 1990. Combining this data with information on recent migration flows by cohorts, we find that an additional year of compulsory education reduces the number of individuals from affected cohorts who migrate in a given year by 9 %. Our results rely on the exogeneity of compulsory schooling laws. A variety of empirical tests indicate that European legislators did not pass compulsory education reforms as a reaction to changes in emigration rates or educational attainment.

Neuronal migration and its disorders affecting the CA3 region

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Richard eBelvindrah

2014-03-01

Full Text Available In this review, we focus on CA3 neuronal migration disorders in the rodent. We begin by introducing the main steps of hippocampal development, and we summarize characteristic hippocampal malformations in human. We then describe various mouse mutants showing structural hippocampal defects. Notably, genes identified in human cortical neuronal migration disorders consistently give rise to a CA3 phenotype when mutated in the mouse. We successively describe their molecular, physiological and behavioral phenotypes that together contribute to a better understanding of CA3-dependent functions. We finally discuss potential factors underlying the CA3 vulnerability revealed by these mouse mutants and that may also contribute to other human neurological and psychiatric disorders.

Expression of macrophage migration inhibitory factor in footpad skin lesions with diabetic neuropathy.

Science.gov (United States)

Up Noh, Sun; Lee, Won-Young; Kim, Won-Serk; Lee, Yong-Taek; Jae Yoon, Kyung

2018-01-01

Background Diabetic neuropathy originating in distal lower extremities is associated with pain early in the disease course, overwhelming in the feet. However, the pathogenesis of diabetic neuropathy remains unclear. Macrophage migration inhibitory factor has been implicated in the onset of neuropathic pain and the development of diabetes. Objective of this study was to observe pain syndromes elicited in the footpad of diabetic neuropathy rat model and to assess the contributory role of migration inhibitory factor in the pathogenesis of diabetic neuropathy. Methods Diabetic neuropathy was made in Sprague Dawley rats by streptozotocin. Pain threshold was evaluated using von Frey monofilaments for 24 weeks. On comparable experiment time after streptozotocin injection, all footpads were prepared for following procedures; glutathione assay, terminal deoxynucleotidyl transferase-mediated biotinylated UTP nick end labeling staining, immunohistochemistry staining, real-time reverse transcription polymerase chain reaction, and Western blot. Additionally, human HaCaT skin keratinocytes were treated with methylglyoxal, transfected with migration inhibitory factor/control small interfering RNA, and prepared for real-time reverse transcription polymerase chain reaction and Western blot. Results As compared to sham group, pain threshold was significantly reduced in diabetic neuropathy group, and glutathione was decreased in footpad skin, simultaneously, cell death was increased. Over-expression of migration inhibitory factor, accompanied by low expression of glyoxalase-I and intraepidermal nerve fibers, was shown on the footpad skin lesions of diabetic neuropathy. But, there was no significance in expression of neurotransmitters and inflammatory mediators such as transient receptor potential vanilloid 1, mas-related G protein coupled receptor D, nuclear factor kappa B, tumor necrosis factor-alpha, and interleukin-6 between diabetic neuropathy group and sham group. Intriguingly

Ouabain affects cell migration via Na,K-ATPase-p130cas and via nucleus-centrosome association.

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Young Ou

Full Text Available Na,K-ATPase is a membrane protein that catalyzes ATP to maintain transmembrane sodium and potassium gradients. In addition, Na,K-ATPase also acts as a signal-transducing receptor for cardiotonic steroids such as ouabain and activates a number of signalling pathways. Several studies report that ouabain affects cell migration. Here we used ouabain at concentrations far below those required to block Na,K-ATPase pump activity and show that it significantly reduced RPE cell migration through two mechanisms. It causes dephosphorylation of a 130 kD protein, which we identify as p130cas. Src is involved, because Src inhibitors, but not inhibitors of other kinases tested, caused a similar reduction in p130cas phosphorylation and ouabain increased the association of Na,K-ATPase and Src. Knockdown of p130cas by siRNA reduced cell migration. Unexpectedly, ouabain induced separation of nucleus and centrosome, also leading to a block in cell migration. Inhibitor and siRNA experiments show that this effect is mediated by ERK1,2. This is the first report showing that ouabain can regulate cell migration by affecting nucleus-centrosome association.

Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migration

Energy Technology Data Exchange (ETDEWEB)

Zhu, Zhong Xin [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Sun, Cong Cong [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Wenzhou People' s Hospital, Wenzhou, Zhejiang (China); Ting Zhu, Yu; Wang, Ying; Wang, Tao; Chi, Li Sha; Cai, Wan Hui [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Zheng, Jia Yong [Wenzhou People' s Hospital, Wenzhou, Zhejiang (China); Zhou, Xuan [Ningbo First Hospital, Ningbo, Zhejiang (China); Cong, Wei Tao [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Li, Xiao Kun, E-mail: proflxk@163.com [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China); Jin, Li Tai, E-mail: jin_litai@126.com [School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang (China)

2017-06-15

Fibroblast migration is a central process in skin wound healing, which requires the coordination of several types of growth factors. bFGF, a well-known fibroblast growth factor (FGF), is able to accelerate fibroblast migration; however, the underlying mechanism of bFGF regulation fibroblast migration remains unclear. Through the RNA-seq analysis, we had identified that the hedgehog (Hh) canonical pathway genes including Smoothened (Smo) and Gli1, were regulated by bFGF. Further analysis revealed that activation of the Hh pathway via up-regulation of Smo promoted fibroblast migration, invasion, and skin wound healing, but which significantly reduced by GANT61, a selective antagonist of Gli1/Gli2. Western blot analyses and siRNA transfection assays demonstrated that Smo acted upstream of phosphoinositide 3-kinase (PI3K)-c-Jun N-terminal kinase (JNK)-β-catenin to promote cell migration. Moreover, RNA-seq and qRT-PCR analyses revealed that Hh pathway genes including Smo and Gli1 were under control of β-catenin, suggesting that β-catenin turn feedback activates Hh signaling. Taken together, our analyses identified a new bFGF-regulating mechanism by which Hh signaling regulates human fibroblast migration, and the data presented here opens a new avenue for the wound healing therapy. - Highlights: • bFGF regulates Hedgehog (Hh) signaling in fibroblasts. • The Smo and Gli two master regulators of Hh signaling positively regulate fibroblast migration. • Smo facilitates β-catenin nuclear translocation via activation PI3K/JNK/GSK3β. • β-catenin positively regulates fibroblast cell migration and the expression of Hh signaling genes including Smo and Gli.

Hedgehog signaling contributes to basic fibroblast growth factor-regulated fibroblast migration

International Nuclear Information System (INIS)

Zhu, Zhong Xin; Sun, Cong Cong; Ting Zhu, Yu; Wang, Ying; Wang, Tao; Chi, Li Sha; Cai, Wan Hui; Zheng, Jia Yong; Zhou, Xuan; Cong, Wei Tao; Li, Xiao Kun; Jin, Li Tai

2017-01-01

Fibroblast migration is a central process in skin wound healing, which requires the coordination of several types of growth factors. bFGF, a well-known fibroblast growth factor (FGF), is able to accelerate fibroblast migration; however, the underlying mechanism of bFGF regulation fibroblast migration remains unclear. Through the RNA-seq analysis, we had identified that the hedgehog (Hh) canonical pathway genes including Smoothened (Smo) and Gli1, were regulated by bFGF. Further analysis revealed that activation of the Hh pathway via up-regulation of Smo promoted fibroblast migration, invasion, and skin wound healing, but which significantly reduced by GANT61, a selective antagonist of Gli1/Gli2. Western blot analyses and siRNA transfection assays demonstrated that Smo acted upstream of phosphoinositide 3-kinase (PI3K)-c-Jun N-terminal kinase (JNK)-β-catenin to promote cell migration. Moreover, RNA-seq and qRT-PCR analyses revealed that Hh pathway genes including Smo and Gli1 were under control of β-catenin, suggesting that β-catenin turn feedback activates Hh signaling. Taken together, our analyses identified a new bFGF-regulating mechanism by which Hh signaling regulates human fibroblast migration, and the data presented here opens a new avenue for the wound healing therapy. - Highlights: • bFGF regulates Hedgehog (Hh) signaling in fibroblasts. • The Smo and Gli two master regulators of Hh signaling positively regulate fibroblast migration. • Smo facilitates β-catenin nuclear translocation via activation PI3K/JNK/GSK3β. • β-catenin positively regulates fibroblast cell migration and the expression of Hh signaling genes including Smo and Gli.

Neuronal migration is regulated by endogenous RNAi and chromatin-binding factor ZFP-1/AF10 in Caenorhabditis elegans.

Science.gov (United States)

Kennedy, Lisa M; Grishok, Alla

2014-05-01

Endogenous short RNAs and the conserved plant homeodomain (PHD) zinc-finger protein ZFP-1/AF10 regulate overlapping sets of genes in Caenorhabditis elegans, which suggests that they control common biological pathways. We have shown recently that the RNAi factor RDE-4 and ZFP-1 negatively modulate transcription of the insulin/PI3 signaling-dependent kinase PDK-1 to promote C. elegans fitness. Moreover, we have demonstrated that the insulin/IGF-1-PI3K-signaling pathway regulates the activity of the DAF-16/FOXO transcription factor in the hypodermis to nonautonomously promote the anterior migrations of the hermaphrodite-specific neurons (HSNs) during embryogenesis of C. elegans. In this study, we implicate the PHD-containing isoform of ZFP-1 and endogenous RNAi in the regulation of HSN migration. ZFP-1 affects HSN migration in part through its negative effect on pdk-1 transcription and modulation of downstream DAF-16 activity. We also identify a novel role for ZFP-1 and RNAi pathway components, including RDE-4, in the regulation of HSN migration in parallel with DAF-16. Therefore, the coordinated activities of DAF-16, ZFP-1, and endogenous RNAi contribute to gene regulation during development to ensure proper neuronal positioning.

Recovery Migration After Hurricanes Katrina and Rita: Spatial Concentration and Intensification in the Migration System.

Science.gov (United States)

Curtis, Katherine J; Fussell, Elizabeth; DeWaard, Jack

2015-08-01

Changes in the human migration systems of the Gulf of Mexico coastline counties affected by Hurricanes Katrina and Rita provide an example of how climate change may affect coastal populations. Crude climate change models predict a mass migration of "climate refugees," but an emerging literature on environmental migration suggests that most migration will be short-distance and short-duration within existing migration systems, with implications for the population recovery of disaster-stricken places. In this research, we derive a series of hypotheses on recovery migration predicting how the migration system of hurricane-affected coastline counties in the Gulf of Mexico was likely to have changed between the pre-disaster and the recovery periods. We test these hypotheses using data from the Internal Revenue Service on annual county-level migration flows, comparing the recovery period migration system (2007-2009) with the pre-disaster period (1999-2004). By observing county-to-county ties and flows, we find that recovery migration was strong: the migration system of the disaster-affected coastline counties became more spatially concentrated, while flows within it intensified and became more urbanized. Our analysis demonstrates how migration systems are likely to be affected by the more intense and frequent storms anticipated by climate change scenarios, with implications for the population recovery of disaster-affected places.

DMPD: Macrophage migration inhibitory factor and host innate immune responses tomicrobes. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 14620137 Macrophage migration inhibitory factor and host innate immune responses to...microbes. Calandra T. Scand J Infect Dis. 2003;35(9):573-6. (.png) (.svg) (.html) (.csml) Show Macrophage migration... inhibitory factor and host innate immune responses tomicrobes. PubmedID 14620137 Title Macrophage migration

Transforming growth factor β induces bone marrow mesenchymal stem cell migration via noncanonical signals and N-cadherin.

Science.gov (United States)

Dubon, Maria Jose; Yu, Jinyeong; Choi, Sanghyuk; Park, Ki-Sook

2018-01-01

Transforming growth factor-beta (TGF-β) induces the migration and mobilization of bone marrow-derived mesenchymal stem cells (BM-MSCs) to maintain bone homeostasis during bone remodeling and facilitate the repair of peripheral tissues. Although many studies have reported the mechanisms through which TGF-β mediates the migration of various types of cells, including cancer cells, the intrinsic cellular mechanisms underlying cellular migration, and mobilization of BM-MSCs mediated by TGF-β are unclear. In this study, we showed that TGF-β activated noncanonical signaling molecules, such as Akt, extracellular signal-regulated kinase 1/2 (ERK1/2), focal adhesion kinase (FAK), and p38, via TGF-β type I receptor in human BM-MSCs and murine BM-MSC-like ST2 cells. Inhibition of Rac1 by NSC23766 and Src by PP2 resulted in impaired TGF-β-mediated migration. These results suggested that the Smad-independent, noncanonical signals activated by TGF-β were necessary for migration. We also showed that N-cadherin-dependent intercellular interactions were required for TGF-β-mediated migration using functional inhibition of N-cadherin with EDTA treatment and a neutralizing antibody (GC-4 antibody) or siRNA-mediated knockdown of N-cadherin. However, N-cadherin knockdown did not affect the global activation of noncanonical signals in response to TGF-β. Therefore, these results suggested that the migration of BM-MSCs in response to TGF-β was mediated through N-cadherin and noncanonical TGF-β signals. © 2017 Wiley Periodicals, Inc.

Associations Between Sociodemographic Characteristics, Pre Migratory and Migratory Factors and Psychological Distress Just After Migration and After Resettlement: The Indian Migration Study.

Science.gov (United States)

Agrawal, Sutapa; Taylor, Fiona C; Moser, Kath; Narayanan, Gitanjali; Kinra, Sanjay; Prabhakaran, Dorairaj; Reddy, Kolli Srinath; Davey Smith, George; Ebrahim, Shah

2015-01-01

Migration is suspected to increase the risk for psychological distress for those who enter a new cultural environment. We investigated the association between sociodemographic characteristics, premigratory and migratory factors and psychological distress in rural-to-urban migrants just after migration and after resettlement. Data from the cross-sectional sib-pair designed Indian Migration Study (IMS, 2005-2007) were used. The analysis focused on 2112 participants aged ≥18 years from the total IMS sample ( n = 7067) who reported being migrant. Psychological distress was assessed based on the responses of the 7-questions in a five-point scale, where the respondents were asked to report about their feelings now and also asked to recall these feelings when they first migrated. The associations were analyzed using multiple logistic regression models. High prevalence of psychological distress was found just after migration (7.3%; 95% confidence interval [CI]: 6.2-8.4) than after settlement (4.7%; 95% CI: 3.8-5.6). Push factors as a reason behind migration and not being able to adjust in the new environment were the main correlates of psychological distress among both the male and female migrants, just after migration. Rural-urban migration is a major phenomenon in India and given the impact of premigratory and migratory related stressors on mental health, early intervention could prevent the development of psychological distress among the migrants.

MiR-375 inhibits the hepatocyte growth factor-elicited migration of mesenchymal stem cells by downregulating Akt signaling.

Science.gov (United States)

He, Lihong; Wang, Xianyao; Kang, Naixin; Xu, Jianwei; Dai, Nan; Xu, Xiaojing; Zhang, Huanxiang

2018-04-01

The migration of mesenchymal stem cells (MSCs) is critical for their use in cell-based therapies. Accumulating evidence suggests that microRNAs are important regulators of MSC migration. Here, we report that the expression of miR-375 was downregulated in MSCs treated with hepatocyte growth factor (HGF), which strongly stimulates the migration of these cells. Overexpression of miR-375 decreased the transfilter migration and the migration velocity of MSCs triggered by HGF. In our efforts to determine the mechanism by which miR-375 affects MSC migration, we found that miR-375 significantly inhibited the activation of Akt by downregulating its phosphorylation at T308 and S473, but had no effect on the activity of mitogen-activated protein kinases. Further, we showed that 3'phosphoinositide-dependent protein kinase-1 (PDK1), an upstream kinase necessary for full activation of Akt, was negatively regulated by miR-375 at the protein level. Moreover, miR-375 suppressed the phosphorylation of focal adhesion kinase (FAK) and paxillin, two important regulators of focal adhesion (FA) assembly and turnover, and decreased the number of FAs at cell periphery. Taken together, our results demonstrate that miR-375 inhibits HGF-elicited migration of MSCs through downregulating the expression of PDK1 and suppressing the activation of Akt, as well as influencing the tyrosine phosphorylation of FAK and paxillin and FA periphery distribution.

Transcription factor FOXO1 promotes cell migration toward exogenous ATP via controlling P2Y1 receptor expression in lymphatic endothelial cells.

Science.gov (United States)

Niimi, Kenta; Ueda, Mizuha; Fukumoto, Moe; Kohara, Misaki; Sawano, Toshinori; Tsuchihashi, Ryo; Shibata, Satoshi; Inagaki, Shinobu; Furuyama, Tatsuo

2017-08-05

Sprouting migration of lymphatic endothelial cell (LEC) is a pivotal step in lymphangiogenic process. However, its molecular mechanism remains unclear including effective migratory attractants. Meanwhile, forkhead transcription factor FOXO1 highly expresses in LEC nuclei, but its significance in LEC migratory activity has not been researched. In this study, we investigated function of FOXO1 transcription factor associated with LEC migration toward exogenous ATP which has recently gathered attentions as a cell migratory attractant. The transwell membrane assay indicated that LECs migrated toward exogenous ATP, which was impaired by FOXO1 knockdown. RT-PCR analysis showed that P2Y1, a purinergic receptor, expression was markedly reduced by FOXO1 knockdown in LECs. Moreover, P2Y1 blockage impaired LEC migration toward exogenous ATP. Western blot analysis revealed that Akt phosphorylation contributed to FOXO1-dependent LEC migration toward exogenous ATP and its blockage affected LEC migratory activity. Furthermore, luciferase reporter assay and ChIP assay suggested that FOXO1 directly bound to a conserved binding site in P2RY1 promoter and regulated its activity. These results indicated that FOXO1 serves a pivotal role in LEC migration toward exogenous ATP via direct transcriptional regulation of P2Y1 receptor. Copyright © 2017 Elsevier Inc. All rights reserved.

Recovery Migration after Hurricanes Katrina and Rita: Spatial Concentration and Intensification in the Migration System

Science.gov (United States)

Fussell, Elizabeth; DeWaard, Jack

2015-01-01

Changes in the human migration systems of Hurricane Katrina- and Rita-affected Gulf of Mexico coastline counties provide an example of how climate change may affect coastal populations. Crude climate change models predict a mass migration of “climate refugees,” but an emerging literature on environmental migration suggests most migration will be short-distance and short-duration within existing migration systems, with implications for the population recovery of disaster-struck places. In this research, we derive a series of hypotheses on recovery migration predicting how the migration system of hurricane-affected coastline counties in the Gulf of Mexico was likely to have changed between the pre-disaster and the recovery periods. We test these hypotheses using data from the Internal Revenue Service on annual county-level migration flows, comparing the recovery period migration system (2007–2009) to the pre-disaster period (1999–2004). By observing county-to-county ties and flows we find that recovery migration was strong, as the migration system of the disaster-affected coastline counties became more spatially concentrated while flows within it intensified and became more urbanized. Our analysis demonstrates how migration systems are likely to be affected by the more intense and frequent storms anticipated by climate change scenarios with implications for the population recovery of disaster-affected places. PMID:26084982

Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes

International Nuclear Information System (INIS)

Ceccarelli, Simona; Cardinali, Giorgia; Aspite, Nicaela; Picardo, Mauro; Marchese, Cinzia; Torrisi, Maria Rosaria; Mancini, Patrizia

2007-01-01

Keratinocyte growth factor (KGF/FGF7) and fibroblast growth factor 10 (FGF10/KGF2) regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (KGFR). KGF induces keratinocyte motility and cytoskeletal rearrangement, whereas a direct role of FGF10 on keratinocyte migration is not clearly established. Here we analyzed the motogenic activity of FGF10 and KGF on human keratinocytes. Migration assays and immunofluorescence of actin cytoskeleton revealed that FGF10 is less efficient than KGF in promoting migration and exerts a delayed effect in inducing lamellipodia and ruffles formation. Both growth factors promoted phosphorylation and subsequent membrane translocation of cortactin, an F-actin binding protein involved in cell migration; however, FGF10-induced cortactin phosphorylation was reduced, more transient and delayed with respect to that promoted by KGF. Cortactin phosphorylation induced by both growth factors was Src-dependent, while its membrane translocation and cell migration were blocked by either Src and PI3K inhibitors, suggesting that both pathways are involved in KGF- and FGF10-dependent motility. Furthermore, siRNA-mediated downregulation of cortactin inhibited KGF- and FGF10-induced migration. These results indicate that cortactin is involved in keratinocyte migration promoted by both KGF and FGF10

Macrophage migration inhibitory factor is elevated in obese adolescents

NARCIS (Netherlands)

Kamchybekov, Uran; Figulla, Hans R.; Gerdes, Norbert; Jung, Christian

2012-01-01

Objectives: The prevalence of obesity in childhood and adolescence is continuing rising. Macrophage migration inhibitory factor (MIF) participates in inflammatory and immune responses as a pro-inflammatory cytokine. The present study aimed to investigate MIF in overweight adolescents. Methods:

The Factors that Affect Indian Migrants' Decision to Stay in or Counter Migrate from the United States: A Study with Special Reference to the Role of Tourism Related Imagery as a Determinant

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Babu P. GEORGE

2007-11-01

Full Text Available In the light of the changing socio-economic realities of the presenttimes, this paper explores the complex dynamics underlying Indian immigrants' decision to continue to stay in the United States or to counter migrate back to India. In a reversal of fortunes, the specific set of conditions that once triggered a massive inflow of economic migrants from India to the US has been causing a counter migration to India. Based on a review of literature and an exploratory study involving focus groups the paper identifiessome of the major migration / counter migration related factors. Then, employing a survey, the relative importance of each of these factors is gauged for individuals associated with different professions. In addition, the study explores as a special case the role of tourism related images about the US being held by immigrants as determinants of their migration related decisions. Tourism images held by the migrants and the tourism opportunities provided by the US act more as hygiene factors than as motivators. In course of theexploration, a number of hypotheses are emerged that are of interest to future researchers. The study has got significant implications for migration / counter migration policy makers, industry practitioners, and the migrants themselves.

The role of wages in the migration of health care professionals from developing countries

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Adams Orvill

2004-04-01

Full Text Available Abstract Several countries are increasingly relying on immigration as a means of coping with domestic shortages of health care professionals. This trend has led to concerns that in many of the source countries – especially within Africa – the outflow of health care professionals is adversely affecting the health care system. This paper examines the role of wages in the migration decision and discusses the likely effect of wage increases in source countries in slowing migration flows. This paper uses data on wage differentials in the health care sector between source country and receiving country (adjusted for purchasing power parity to test the hypothesis that larger wage differentials lead to a larger supply of health care migrants. Differences in other important factors affecting migration are discussed and, where available, data are presented. There is little correlation between the supply of health care migrants and the size of the wage differential between source and destination country. In cases where data are available on other factors affecting migration, controlling for these factors does not affect the result. At current levels, wage differentials between source and destination country are so large that small increases in health care wages in source countries are unlikely to affect significantly the supply of health care migrants. The results suggest that non-wage instruments might be more effective in altering migration flows.

MIGRATION INTEGRATION AS A FACTOR OF ECONOMIC AND REGIONAL DEVELOPMENT IN THE EUROPEAN UNION

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Petronela Daniela FERARU

2015-10-01

Full Text Available International migration, together with economic and financial crisis or the different socio-economic development of Member States, is a serious threat to security in Europe. Population migration as a threatening factor, places the European Union in the face of a decision to establish clear policies for the establishment of a climate of external security, both for the migrant population and for the rest of the population. All in all, this study will centre on the following hypothesis: the better we know the challenges of international migration in the European Union and its Member States the more the European policies to mitigate negative effects of the world will be diminished. The aim is to highlight aspects pertaining to migration integration as a factor of economic, social and regional development in the European Union, and less as a factor of destabilization and insecurity. In other words, a good knowledge of the phenomenon leads to drawing up effective policies to reduce hazards, risks, threats and negative effects that happen today due to the increasing number of immigrants. Finally, the study will present a series of conclusions, including on the work hypothesis verification and some proposals related to migration integration efficiency as a factor of regional and economic development in the European Union.

Strength training and testosterone treatment have opposing effects on migration inhibitor factor levels in ageing men

DEFF Research Database (Denmark)

Glintborg, D.; Christensen, L. L.; Kvorning, T.

2013-01-01

Strength Training and Testosterone Treatment Have Opposing Effects on Migration Inhibitor Factor Levels in Ageing Men......Strength Training and Testosterone Treatment Have Opposing Effects on Migration Inhibitor Factor Levels in Ageing Men...

Migration towards fibre to the home: key cost factors

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Zhou, L. W.; Mas Machuca, C.; Zhao, R.; Grunert, K.

2010-12-01

This paper presents a comprehensive cost model for migration towards FTTH, some case study results from different network area scenarios, as well as the identification of the most important cost factors to be considered by operators aiming at increasing the profitability of their networks.

Plasma rich in growth factors promotes dermal fibroblast proliferation, migration and biosynthetic activity.

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Anitua, E; Pino, A; Orive, G

2016-11-02

The use of plasma rich in growth factors (PRGF) has gained importance in many medical fields due to its regenerative potential. The aim of this study is to evaluate the effects of PRGF on primary skin fibroblasts assessing cell proliferation, migration and secretion of growth factors. The age of the patients from who PRGF was prepared was also studied to determine whether it influenced the outcomes. Human dermal fibroblasts were isolated from three healthy volunteers. Using PRGF-Endoret technology, PRGF was prepared from two groups of different ages (18-35 years and 50+ years). The effects of increasing concentration of PRGF (5%, 10% and 20%) on cell proliferation and migration was evaluated. Biosynthetic behaviour of cells was also analysed measuring vascular endothelial growth factor (VEGF), transforming growth factor b1 (TGFb1) and pro-collagen type I secreted levels with or without PRGF treatment. Mean platelet enrichment reached 2.4X and 2X in 18-35 and 50+ groups respectively. A dose-dependent response was observed in proliferation assays achieving the highest levels with 20% PRGF. Migration was also promoted in cells but not in a dose-dependent manner. Cell proliferation and migration outcomes obtained with PRGF (from both groups) were significantly higher compared to non-stimulated groups (pPRGF, however, with the exception of VEGF, no statistical significances were observed between the different age groups. Results from this study concluded that PRGF is safe and effective in stimulating skin regeneration by enhancing proliferation, migration and expression of pivotal bioactive molecules involved in wound healing and haemostasis.

[Internal migration trends and regional dynamics].

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Trabelsi, M

1992-01-01

This study concerns aspects of regional development in Tunisia. It specifically considers how economic factors affect income differentials among regions, and ways in which these in turn influence trends in internal migration. The effect of these trends on urbanization is also explored.

Factors influencing the migration of West African health professionals

African Journals Online (AJOL)

Introduction: The West African health sector is characterized by a human resource base lacking in numbers and specialized skills. Among the contributory factors to this lack of human resource for health workforce include but not limited to the migration of health professionals. Methods: This cross-sectional survey targeted ...

Factors affecting gas migration and contaminant redistribution in heterogeneous porous media subject to electrical resistance heating.

Science.gov (United States)

Munholland, Jonah L; Mumford, Kevin G; Kueper, Bernard H

2016-01-01

A series of intermediate-scale laboratory experiments were completed in a two-dimensional flow cell to investigate gas production and migration during the application of electrical resistance heating (ERH) for the removal of dense non-aqueous phase liquids (DNAPLs). Experiments consisted of heating water in homogeneous silica sand and heating 270 mL of trichloroethene (TCE) and chloroform (CF) DNAPL pools in heterogeneous silica sands, both under flowing groundwater conditions. Spatial and temporal distributions of temperature were measured using thermocouples and observations of gas production and migration were collected using front-face image capture throughout the experiments. Post-treatment soil samples were collected and analyzed to assess DNAPL removal. Results of experiments performed in homogeneous sand subject to different groundwater flow rates showed that high groundwater velocities can limit subsurface heating rates. In the DNAPL pool experiments, temperatures increased to achieve DNAPL-water co-boiling, creating estimated gas volumes of 131 and 114 L that originated from the TCE and CF pools, respectively. Produced gas migrated vertically, entered a coarse sand lens and subsequently migrated laterally beneath an overlying capillary barrier to outside the heated treatment zone where 31-56% of the original DNAPL condensed back into a DNAPL phase. These findings demonstrate that layered heterogeneity can potentially facilitate the transport of contaminants outside the treatment zone by mobilization and condensation of gas phases during ERH applications. This underscores the need for vapor phase recovery and/or control mechanisms below the water table during application of ERH in heterogeneous porous media during the co-boiling stage, which occurs prior to reaching the boiling point of water. Copyright © 2015 Elsevier B.V. All rights reserved.

Modification of meander migration by bank failures

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Motta, D.; Langendoen, E. J.; Abad, J. D.; García, M. H.

2014-05-01

Meander migration and planform evolution depend on the resistance to erosion of the floodplain materials. To date, research to quantify meandering river adjustment has largely focused on resistance to erosion properties that vary horizontally. This paper evaluates the combined effect of horizontal and vertical floodplain material heterogeneity on meander migration by simulating fluvial erosion and cantilever and planar bank mass failure processes responsible for bank retreat. The impact of stream bank failures on meander migration is conceptualized in our RVR Meander model through a bank armoring factor associated with the dynamics of slump blocks produced by cantilever and planar failures. Simulation periods smaller than the time to cutoff are considered, such that all planform complexity is caused by bank erosion processes and floodplain heterogeneity and not by cutoff dynamics. Cantilever failure continuously affects meander migration, because it is primarily controlled by the fluvial erosion at the bank toe. Hence, it impacts migration rates and meander shapes through the horizontal and vertical distribution of erodibility of floodplain materials. Planar failures are more episodic. However, in floodplain areas characterized by less cohesive materials, they can affect meander evolution in a sustained way and produce preferential migration patterns. Model results show that besides the hydrodynamics, bed morphology and horizontal floodplain heterogeneity, floodplain stratigraphy can significantly affect meander evolution, both in terms of migration rates and planform shapes. Specifically, downstream meander migration can either increase or decrease with respect to the case of a homogeneous floodplain; lateral migration generally decreases as result of bank protection due to slump blocks; and the effect on bend skewness depends on the location and volumes of failed bank material caused by cantilever and planar failures along the bends, with possible achievement of

Mertk deficiency affects macrophage directional migration via disruption of cytoskeletal organization.

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Yong Tang

Full Text Available Mertk belongs to the Tyro3, Axl and Mertk (TAM family of receptor tyrosine kinases, and plays a pivotal role in regulation of cytoskeletal rearrangement during phagocytosis. Phagocytosis by either professional or non-professional phagocytes is impaired in the Mertk deficient individual. In the present study, we further investigated the effects of Mertk mutation on peritoneal macrophage morphology, attachment, spreading and movement. Mertk-mutated macrophages exhibited decreased attachment, weak spreading, loss of spindle-like body shape and lack of clear leading and trailing edges within the first few hours of culture, as observed by environmental scanning electron microscopy. Time-lapse video photography recording showed that macrophage without Mertk conducted mainly random movement with oscillating swing around the cell body, and lost the directional migration action seen on the WT cells. Western blotting showed a decreased phosphorylation of focal adhesion kinase (FAK. Immunocytochemistry revealed that actin filaments and dynamic protein myosin II failed to concentrate in the leading edge of migrating cells. Microtubules were localized mainly in one side of mutant cell body, with no clear MTOC and associated radially-distributed microtubule bundles, which were clearly evident in the WT cells. Our results suggest that Mertk deficiency affects not only phagocytosis but also cell shape and migration, likely through a common regulatory mechanism on cytoskeletons.

Lines of evidence for environmentally driven human migration

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Davis, K. F.; D'Odorico, P.

2012-12-01

International human migration is an important mechanism that affects, and is affected by, various human and natural systems. With the number of people living outside their countries of origin currently estimated at 214 million people and projected to potentially reach more than 400 million people by mid-century, the topic of international human movements presents possible advantages and pitfalls for both sending and receiving countries on multiple fronts (e.g. economic, environmental, political and cultural). Understanding how human migration interacts with human and natural systems is therefore essential in realizing a sustainable and balanced future. While the study of international migration has historically been motivated largely by economic and political interests, the issue of environmentally induced migration has become increasingly important in light of a rapidly changing climate in conjunction with increasing population pressure on many important resources. Particularly in terms of theoretical and conceptual discussions, environmentally induced human migration has been receiving increased attention in the literature. To date, few studies - many of which focus on internal (intra-national) or regional migration - have attempted to quantify the interactions of human migration and the environment, with little attention paid to the global scale as a result of varying regional factors and lack of sufficient data. Recently available global bilateral migration datasets have been developed that allow for a more comprehensive understanding of human movements between all countries. With these datasets, we seek to elucidate environmental drivers of human migration over the past half-century using a multi-pronged approach. First, using a recently developed universal radiation model, we examine human movements based solely on global population distribution. Next, by comparison of migration movements with selected economic, environmental and human welfare indicators, we

Psychosocial factors of migration: adaptation and application of the health belief model

NARCIS (Netherlands)

Groenewold, W.G.F.; de Bruijn, B.J.; Bilsborrow, R.

2012-01-01

Psychosocial factors influencing behaviour play a central role in health research but seem under-explored in migration research. This is unfortunate because these factors, which include knowledge, attitudes, beliefs, intentions and personality traits, provide essential and potentially effective

A preference for migration

OpenAIRE

Stark, Oded

2007-01-01

At least to some extent migration behavior is the outcome of a preference for migration. The pattern of migration as an outcome of a preference for migration depends on two key factors: imitation technology and migration feasibility. We show that these factors jointly determine the outcome of a preference for migration and we provide examples that illustrate how the prevalence and transmission of a migration-forming preference yield distinct migration patterns. In particular, the imitation of...

Morphological constraints on changing avian migration phenology.

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Møller, A P; Rubolini, D; Saino, N

2017-06-01

Many organisms at northern latitudes have responded to climate warming by advancing their spring phenology. Birds are known to show earlier timing of spring migration and reproduction in response to warmer springs. However, species show heterogeneous phenological responses to climate warming, with those that have not advanced or have delayed migration phenology experiencing population declines. Although some traits (such as migration distance) partly explain heterogeneity in phenological responses, the factors affecting interspecies differences in the responsiveness to climate warming have yet to be fully explored. In this comparative study, we investigate whether variation in wing aspect ratio (reflecting relative wing narrowness), an ecomorphological trait that is strongly associated with flight efficiency and migratory behaviour, affects the ability to advance timing of spring migration during 1960-2006 in a set of 80 European migratory bird species. Species with larger aspect ratio (longer and narrower wings) showed smaller advancement of timing of spring migration compared to species with smaller aspect ratio (shorter and wider wings) while controlling for phylogeny, migration distance and other life-history traits. In turn, migration distance positively predicted aspect ratio across species. Hence, species that are better adapted to migration appear to be more constrained in responding phenologically to rapid climate warming by advancing timing of spring migration. Our findings corroborate the idea that aspect ratio is a major evolutionary correlate of migration, and suggest that selection for energetically efficient flights, as reflected by high aspect ratio, may hinder phenotypically plastic/microevolutionary adjustments of migration phenology to ongoing climatic changes. © 2017 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2017 European Society For Evolutionary Biology.

On the move: migration, urbanization and development in Papua New Guinea.

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Walsh, A C

1987-03-01

"Migration and urbanization data from Papua New Guinea's first truly national census in 1980 are considered against a backdrop of spatial and social inequalities. Source and destination factors affecting migration flows and destinations are found to relate to population density, availability of rural wages, ease of access, destination wage-earning opportunities, historical linkages and present day developments. Short-distance migration differs from longer-distance migration; many migrants are short-term, and possibly circular, migrants. Migration and urbanization are considered part of the same process of developmental change." A section is included on earlier censuses and surveys, data reliability, and related problems.

Determinants of labour migration of elite sport coaches.

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Orlowski, Johannes; Wicker, Pamela; Breuer, Christoph

2016-09-01

Previous research examining labour migration in sport focused on athletes in professional team sports. The purpose of this study is to analyse the factors influencing the migration probability of elite sport coaches in Germany (i.e. national coaches, state coaches, and coaches at Olympic training bases). From a theoretical perspective, labour migration of athletes is affected by economic, social, political, competitive, geographic and cultural factors. This study examines whether these factors can be applied to coaches. Primary data were collected using an online survey of elite sport coaches in Germany. Applying a conjoint design, respondents were presented with 10 migration scenarios leading to a sample size of n = 1860 for the empirical analysis. In the scenarios, the coaching position openings abroad differed in terms of income level, contract length, weekly workload, responsibility for personnel, reputation of coaching job, career perspectives, sporting performance of athletes, distance from Germany, and predominant job language. Coaches were asked for their migration probability contingent on the specific scenario. On average, migration probability was 24.2%. The results of regression analysis showed that higher income, contracts of longer duration, responsibility for personnel and speaking the respective language significantly increased the migration probability, while distances of nine flight hours and more, lower reputation and career perspectives reduced it. The findings have implications for policy-makers: they indicate in what areas the situation of coaches needs improvement to increase the likelihood of retaining elite sport coaches in the German sport system.

The contribution of ecosystem services to place utility as a determinant of migration decision-making

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Adams, Helen; Adger, W. Neil

2013-03-01

Environment migration research has sought to provide an account of how environmental risks and resources affect migration and mobility. Part of that effort has focused on the role of the environment in providing secure livelihoods through provisioning ecosystem services. However, many of the models of environment migration linkages fail to acknowledge the importance of social and psychological factors in the decision to migrate. Here, we seek to provide a more comprehensive model of migration decision-making under environmental change by investigating the attachment people form to place, and the role of the environment in creating that attachment. We hypothesize that environmental factors enter the migration decision-making process through their contribution to place utility, defined as a function of both affective and instrumental bonds to location, and that ecosystem services, the aspects of ecosystems that create wellbeing, contribute to both components of place utility. We test these ideas in four rural highland settlements in Peru sampled along an altitudinal gradient. We find that non-economic ecosystem services are important in creating place attachment and that ecological place attachment exists independently of use of provisioning ecosystem services. Individuals’ attitudes to ecosystem services vary with the type of ecosystem services available at a location and the degree of rurality. While social and economic factors are the dominant drivers of migration in these locations, a loss of non-provisioning ecosystem services leads to a decrease in place utility and commitment to place, determining factors in the decision to migrate. The findings suggest that policy interventions encouraging migration as an adaptation to environmental change will have limited success if they only focus on provisioning services. A much wider set of individuals will experience a decrease in place utility, and migration will be unable to alleviate that decrease since the factors

The contribution of ecosystem services to place utility as a determinant of migration decision-making

International Nuclear Information System (INIS)

Adams, Helen; Neil Adger, W

2013-01-01

Environment migration research has sought to provide an account of how environmental risks and resources affect migration and mobility. Part of that effort has focused on the role of the environment in providing secure livelihoods through provisioning ecosystem services. However, many of the models of environment migration linkages fail to acknowledge the importance of social and psychological factors in the decision to migrate. Here, we seek to provide a more comprehensive model of migration decision-making under environmental change by investigating the attachment people form to place, and the role of the environment in creating that attachment. We hypothesize that environmental factors enter the migration decision-making process through their contribution to place utility, defined as a function of both affective and instrumental bonds to location, and that ecosystem services, the aspects of ecosystems that create wellbeing, contribute to both components of place utility. We test these ideas in four rural highland settlements in Peru sampled along an altitudinal gradient. We find that non-economic ecosystem services are important in creating place attachment and that ecological place attachment exists independently of use of provisioning ecosystem services. Individuals’ attitudes to ecosystem services vary with the type of ecosystem services available at a location and the degree of rurality. While social and economic factors are the dominant drivers of migration in these locations, a loss of non-provisioning ecosystem services leads to a decrease in place utility and commitment to place, determining factors in the decision to migrate. The findings suggest that policy interventions encouraging migration as an adaptation to environmental change will have limited success if they only focus on provisioning services. A much wider set of individuals will experience a decrease in place utility, and migration will be unable to alleviate that decrease since the factors

International Labour Migration. A Present-Day Phenomenon Using the Example of Slovakia

Directory of Open Access Journals (Sweden)

Kolláriková Petra

2016-06-01

Full Text Available The term migration encompasses a dynamic and complex process affected by numerous components that at the same time creates numerous relationships and factors. Nowadays, migration is understood as a natural phenomenon that occurs in every state and as a source of cultural diversity or cultural contribution. Migration touches upon a great number of issues in the fields of demography, economy, language, religion, national security and politics.

Insulin-like Growth Factor Binding Protein 7 Mediates Glioma Cell Growth and Migration

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Wei Jiang

2008-12-01

Full Text Available Insulin-like growth factor binding protein 7 (IGFBP-7 is the only member of the IGFBP superfamily that binds strongly to insulin, suggesting that IGFBP-7 may have different functions from other IGFBPs. Unlike other IGFBPs, the expression and functions of IGFBP-7 in glioma tumors have not been reported. Using cDNA microarray analysis, we found that expression of IGFBP-7 correlated with the grade of glioma tumors and the overall patient survival. This finding was further validated by real-time reverse transcription-polymerase chain reaction and Western blot analysis. We used RNAi to examine the role of IGFBP-7 in glioma cells, inhibiting IGFBP-7 expression by short interfering RNA transfection. Cell proliferation was suppressed after IGFBP-7 expression was inhibited for 5 days, and glioma cell growth was stimulated consistently by the addition of recombinant IGFBP-7 protein. Moreover, glioma cell migration was attenuated by IGFBP-7 depletion but enhanced by IGFBP-7 overexpression and addition. Overexpression of AKT1 in IGFBP-7-overxpressed cells attenuated the IGFBP-7-promoted migration and further enhanced inhibition of IGFBP-7 depletion on the migration. Phosphorylation of AKT and Erk1/2 was also inversely regulated by IGFBP-7 expression. These two factors together suggest that IGFBP-7 can regulate glioma cell migration through the AKT-ERK pathway, thereby playing an important role in glioma growth and migration.

Allosuppressor T lymphocytes abolish migration inhibition factor production in autoimmune thyroid disease: evidence from radiosensitivity experiments

International Nuclear Information System (INIS)

Topliss, D.J.; Okita, N.; Lewis, M.; Row, V.V.; Volpe, R.

1981-01-01

The ability of normal T lymphocytes to abolish the production of migration inhibition factor by antigen-sensitized T lymphocytes of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in response to thyroid antigen has been studied by a modified migration inhibition factor test using isolated T lymphocytes alone. The production of migration inhibition factor was consistently abolished when normal T lymphocytes were mixed with GD or HT T lymphocytes in various ratios (1:9, 2:8, 5:5) as reported previously (Okita et al., 1980b). However, prior in-vitro irradiation (1000 rad) of the normal T lymphocytes resulted in loss of their ability to abolish migration inhibition factor production by the antigen-sensitized T lymphocytes of GD and HT. The effect is consistent with the radiosensitivity of suppressor T lymphocytes and indicates that the effect of normal T lymphocytes on GD and HT T lymphocytes is one of allosuppression. The results support the view that there is a defect in suppressor T cell function in GD and HT. (author)

Factors affecting access to healthcare services by intermarried Filipino women in rural Tasmania: a qualitative study.

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Hannah, Chona T; Lê, Quynh

2012-10-01

Access to health care services is vital for every migrant's health and wellbeing. However, migrants' cultural health beliefs and views can hinder their ability to access available services. This study examined factors affecting access to healthcare services for intermarried Filipino women in rural Tasmania, Australia. A qualitative approach using semi-structured interviews was employed to investigate the factors affecting access to healthcare services for 30 intermarried Filipino women in rural Tasmania. The study used grounded theory and thematic analysis for its data analysis. Nvivo v8 (www.qsrinternational.com) was also used to assist the data coding process and analysis. Five influencing factors were identified: (1) language or communication barriers; (2) area of origin in the Philippines; (3) cultural barriers; (4) length of stay in Tasmania; and (5) expectations of healthcare services before and after migration. Factors affecting intermarried Filipino women in accessing healthcare services are shaped by their socio-demographic and cultural background. The insights gained from this study are useful to health policy-makers, healthcare professionals and to intermarried female migrants. The factors identified can serve as a guide to improve healthcare access for Filipino women and other migrants.

Migration Factors in West African Immigrant Parents' Perceptions of Their Children's Neighborhood Safety.

Science.gov (United States)

Rasmussen, Andrew; Cissé, Aïcha; Han, Ying; Roubeni, Sonia

2018-02-12

Immigrants make up large proportions of many low-income neighborhoods, but have been largely ignored in the neighborhood safety literature. We examined perceived safety's association with migration using a six-item, child-specific measure of parents' perceptions of school-aged (5-12 years of age) children's safety in a sample of 93 West African immigrant parents in New York City. Aims of the study were (a) to identify pre-migration correlates (e.g., trauma in home countries), (b) to identify migration-related correlates (e.g., immigration status, time spent separated from children during migration), and (c) to identify pre-migration and migration correlates that accounted for variance after controlling for non-migration-related correlates (e.g., neighborhood crime, parents' psychological distress). In a linear regression model, children's safety was associated with borough of residence, greater English ability, less emotional distress, less parenting difficulty, and a history of child separation. Parents' and children's gender, parents' immigration status, and the number of contacts in the U.S. pre-migration and pre-migration trauma were not associated with children's safety. That child separation was positively associated with safety perceptions suggests that the processes that facilitate parent-child separation might be reconceptualized as strengths for transnational families. Integrating migration-related factors into the discussion of neighborhood safety for immigrant populations allows for more nuanced views of immigrant families' well-being in host countries. © Society for Community Research and Action 2018.

Social, economic and demographic factors relating to interregional migration in the Philippines: 1970-1980.

Science.gov (United States)

Llasa, R N

1982-10-01

The study attempts to identify the different social, economic, and demographic factors relating to interregional migration in the Philippines for the decade 1970-1980. The dependent variable used is the regional net migration rate estimated through the national growth rate method. Using the rank order correlation technique, the relationship between the dependent variable and the different independent variables were determined. It is found that the following variables were positively related to interregional migration: percentage of 20-29 year old population, previous in-migrants, median family income, land area, primacy index, level of urbanization, level of education, and percentage of never married population. However, the first 3 variables mentioned seem to be the most significant determinants of regional net migration rates, which indicates that net migration in the Philippines during the last decade tends to be more dependent upon previous migration patterns and less dependent upon current socioeconomic development.

Serum Macrophage Migration Inhibitory Factor in the Prediction of Preterm Delivery

DEFF Research Database (Denmark)

Pearce, Brad; Garvin, Sicily; Grove, Jakob

2008-01-01

Objective: Macrophage migration inhibitory factor (MIF) is a soluble mediator that helps govern the interaction between cytokines and stress hormones (e.g. cortisol). We determined if maternal MIF levels predicted subsequent preterm delivery (PTD). Study Design: A nested case-control study...

CITY ATTRACTIVENESS AS A FACTOR OF FORMATION OF STUDENTS' ATTITUDES TO MIGRATION

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Lychko S. K.

2014-03-01

Full Text Available This article deals with the problem of increasing of city attractiveness and competitiveness for saving and development of territory’s human capital (on the example of students as one of the most mobile group. The study’s main objective is to identify student’s migration attitudes and its connection with territory perception and student’s features. The idea of migration attitudes is clarified through its features (presence, direction, formation. Furthermore, it was made an analysis and extension of factors, which could determine decision of students to leave. Information base consists of results of online-poll among NSU students, conducted in the end of 2012 - beginning of 2013 year. According to the online-poll, authors found out characteristics, which determine differentiation of migration attitudes. It’s shown the influence of subjective perception of territory’s features and city attractiveness on the process of formation of migration attitudes of students (it’s discovered the differentiation of direction and formation of migration attitudes in groups with different perception. There is the tendency of more loyalty to the territory among students oriented on living in Novosibirsk. Students more oriented on leaving if they have a higher level of expectations of the territory as a potential residence. Despite of the fact that migration attitudes are not necessarily to be implemented in practice, information about it allow estimating potential mobility and migration potential of this group, which is important to consider during creation of city’s marketing strategy.

Investigation of Fibres Migration in Cotton/Polypropylene Blended Yarn

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Dzmitry RYKLIN

2014-09-01

Full Text Available This study is devoted to theoretical and experimental research of fibres migration in blended yarns. A hypothesis states that due to fibres migration their tension in yarn becomes equal. On the basis of that hypothesis, we identified the factors that affect the migration. The main factors influencing are differences in Young's modulus and density of fibres. Simulating the fibres migration we obtained the formulae for determining the proportion of fibres in the external and inner layers of blended yarn. These formulae were proved by analysis of cross-section of cotton/polypropylene yarn. Results of blended yarn processing in knitting showed that migration of polypropylene fibres in direction to the yarn surface leads to significant increase of yarn breakages due to growth of its friction coefficient. Reduction of the input yarn tension by 10 % – 15 % helped to stabilize the process of knitting. It was found that the usage of theoretical information about fibres migration allows to draw conclusions about the necessity of adjustments to settings of subsequent processing of blended yarns. DOI: http://dx.doi.org/10.5755/j01.ms.20.3.4610

Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians

Science.gov (United States)

Abnave, Prasad; Aboukhatwa, Ellen; Kosaka, Nobuyoshi; Thompson, James; Hill, Mark A.

2017-01-01

Migration of stem cells underpins the physiology of metazoan animals. For tissues to be maintained, stem cells and their progeny must migrate and differentiate in the correct positions. This need is even more acute after tissue damage by wounding or pathogenic infection. Inappropriate migration also underpins metastasis. Despite this, few mechanistic studies address stem cell migration during repair or homeostasis in adult tissues. Here, we present a shielded X-ray irradiation assay that allows us to follow stem cell migration in planarians. We demonstrate the use of this system to study the molecular control of stem cell migration and show that snail-1, snail-2 and zeb-1 EMT transcription factor homologs are necessary for cell migration to wound sites and for the establishment of migratory cell morphology. We also observed that stem cells undergo homeostatic migration to anterior regions that lack local stem cells, in the absence of injury, maintaining tissue homeostasis. This requires the polarity determinant notum. Our work establishes planarians as a suitable model for further in-depth study of the processes controlling stem cell migration in vivo. PMID:28893948

Avian migrants adjust migration in response to environmental conditions en route

DEFF Research Database (Denmark)

Tøttrup, Anders P; Thorup, Kasper; Rainio, Kalle

2008-01-01

The onset of migration in birds is assumed to be primarily under endogenous control in long-distance migrants. Recently, climate changes appear to have been driving a rapid change in breeding area arrival. However, little is known about the climatic factors affecting migratory birds during...... covering the entire migration period every year from observatories located in the Middle East and northern Europe, we show that passage of the Sahara Desert is delayed and correlated with improved conditions in the wintering areas. By contrast, migrants travel more rapidly through Europe, and adjust...... the migration cycle, or whether recently reported phenological changes are caused by plastic behavioural responses or evolutionary change. Here, we investigate how environmental conditions in the wintering areas as well as en route towards breeding areas affect timing of migration. Using data from 1984 to 2004...

Light pollution is greatest within migration passage areas for nocturnally-migrating birds around the world.

Science.gov (United States)

Cabrera-Cruz, Sergio A; Smolinsky, Jaclyn A; Buler, Jeffrey J

2018-02-19

Excessive or misdirected artificial light at night (ALAN) produces light pollution that influences several aspects of the biology and ecology of birds, including disruption of circadian rhythms and disorientation during flight. Many migrating birds traverse large expanses of land twice every year at night when ALAN illuminates the sky. Considering the extensive and increasing encroachment of light pollution around the world, we evaluated the association of the annual mean ALAN intensity over land within the geographic ranges of 298 nocturnally migrating bird species with five factors: phase of annual cycle, mean distance between breeding and non-breeding ranges, range size, global hemisphere of range, and IUCN category of conservation concern. Light pollution within geographic ranges was relatively greater during the migration season, for shorter-distance migrants, for species with smaller ranges, and for species in the western hemisphere. Our results suggest that migratory birds may be subject to the effects of light pollution particularly during migration, the most critical stage in their annual cycle. We hope these results will spur further research on how light pollution affects not only migrating birds, but also other highly mobile animals throughout their annual cycle.

Factors Affecting the Recurrence of Giant Cell Tumor of Bone After Surgery: A Clinicopathological Study of 80 Cases from a Single Center

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Dong-dong Cheng

2015-07-01

Full Text Available Background/Aims: This aim of the present study was to identify specific markers determining the recurrence of the giant cell tumor of bone (GCTB. Methods: This study involved the clinicopathological analysis of 80 cases. All of the clinical features, pathological fracture, Campanacci grade, histological features and surgical methods were reviewed. Immunohistochemistry was used to detect the expression of Ki-67, CD147, mutant p53 and p63 in GCTB. Comparisons between different groups were performed using the Chi-square test. The risk factors affecting recurrence were analyzed using a binary logistic model. Kaplan-Meier analysis was employed for the survival analysis between the groups. Cell proliferation assays, migration and invasion assays were used to detect the function of CD147 on GCTB in vitro. Results: The univariate analysis showed that Ki-67 and CD147 expression, pathological fracture, Campanacci grade and surgical method were associated with recurrence. The multivariate analysis revealed that CD147 expression, Campanacci grade and surgical method were the factors affecting GCTB recurrence. In addition, the Kaplan-Meier analysis revealed that these factors affected tumor-free survival time. In vitro study revealed that the CD147 knockdown by small interfering RNA (siRNA technique dramatically reduced the proliferation, migration and invasion of GCTB. Conclusion: Our results suggest that CD147 may serve as an adequate marker for GCTB recurrence. Campanacci grade is a risk factor for GCTB recurrence, which is also affected by the surgical method used.

PLACENTAL SECRETORY FACTORS INFLUENCE TO THP-1 CELLS PHENOTYPE AND THP-1 CELLS TRANSENDOTHELIAL MIGRATION

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O. I. Stepanova

2013-01-01

Full Text Available Decidual and placental macrophage pools are renewed due to its transendothelial monocyte migration from peripheral blood. Tissue macrophages control placental development and provide fetomaternal immunological tolerance. Preeclamptic pregnancy is accompanied by increased monocyte migration to decidual tissue and local inflammatory events. Regulatory mechanisms of monocyte recruitment to placental and decidual tissues is still unclear. Therefore we investigated the influence soluble placental factors (SPFs during the first- and third-trimester normal pregnancy, as compared to effects of these factors in preeclamptic pregnancy. We studied biological actions of SPF upon transendothelial migration of monocyte-like THP-1 cells and their phenotypic pattern. Transendothelial migration of THP-1 cells was more intensive with firsttrimester SPFs from normal pregnancy, when compared with third-trimester samples, and it was accompanied by decreased CD11a expression. SPFs from pre-eclamptic pregnancy caused an increase in transendothelial migration of THP-1 cells, as compared to SPFs from normal pregnancies, being accompanied by increased CD11b expression. The present study was supported by grants ГК №  02.740.11.0711, НШ-3594.2010.7, МД-150.2011.7 and a grant from St.-Petersburg Goverment for young scientists.

Numerical examination of the factors controlling DNAPL migration through a single fracture.

Science.gov (United States)

Reynolds, D A; Kueper, B H

2002-01-01

The migration of five dense nonaqueous phase liquids (DNAPLs) through a single fracture in a clay aquitard was numerically simulated with the use of a compositional simulator. The effects of fracture aperture, fracture dip, matrix porosity, and matrix organic carbon content on the migration of chlorobenzene, 1,2-dichloroethylene, trichloroethylene, tetra-chloroethylene, and 1,2-dibromoethane were examined. Boundary conditions were chosen such that DNAPL entry into the system was allowed to vary according to the stresses applied. The aperture is the most important factor of those studied controlling the migration rate of DNAPL through a single fracture embedded in a clay matrix. Loss of mass to the matrix through diffusion does not significantly retard the migration rate of the DNAPL, particularly in larger aperture fractures (e.g., 50 microm). With time, the ratio of diffusive loss to the matrix to DNAPL flux into the fracture approaches an asymptotic value lower than unity. The implication is that matrix diffusion cannot arrest the migration of DNAPL in a single fracture. The complex relationships between density, viscosity, and solubility that, to some extent, govern the migration of DNAPL through these systems prevent accurate predictions without the use of numerical models. The contamination potential of the migrating DNAPL is significantly increased through the transfer of mass to the matrix. The occurrence of opposite concentration gradients within the matrix can cause dissolved phase contamination to exist in the system for more than 1000 years after the DNAPL has been completely removed from the fracture.

Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration.

Science.gov (United States)

Somogyi, Kálmán; Rørth, Pernille

2004-07-01

Cells migrating through a tissue exert force via their cytoskeleton and are themselves subject to tension, but the effects of physical forces on cell behavior in vivo are poorly understood. Border cell migration during Drosophila oogenesis is a useful model for invasive cell movement. We report that this migration requires the activity of the transcriptional factor serum response factor (SRF) and its cofactor MAL-D and present evidence that nuclear accumulation of MAL-D is induced by cell stretching. Border cells that cannot migrate lack nuclear MAL-D but can accumulate it if they are pulled by other migrating cells. Like mammalian MAL, MAL-D also responds to activated Diaphanous, which affects actin dynamics. MAL-D/SRF activity is required to build a robust actin cytoskeleton in the migrating cells; mutant cells break apart when initiating migration. Thus, tension-induced MAL-D activity may provide a feedback mechanism for enhancing cytoskeletal strength during invasive migration.

The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer

International Nuclear Information System (INIS)

Akkiprik, Mustafa; Hu, Limei; Sahin, Aysegul; Hao, Xishan; Zhang, Wei

2009-01-01

Insulin-like growth factor binding protein 5 (IGFBP5) has been shown to be associated with breast cancer metastasis in clinical marker studies. However, a major difficulty in understanding how IGFBP5 functions in this capacity is the paradoxical observation that ectopic overexpression of IGFBP5 in breast cancer cell lines results in suppressed cellular proliferation. In cancer tissues, IGFBP5 resides mainly in the cytoplasm; however, in transfected cells, IGFBP5 is mainly located in the nucleus. We hypothesized that subcellular localization of IGFBP5 affects its functions in host cells. To test this hypothesis, we generated wild-type and mutant IGFBP5 expression constructs. The mutation occurs within the nuclear localization sequence (NLS) of the protein and is generated by site-directed mutagenesis using the wild-type IGFBP5 expression construct as a template. Next, we transfected each expression construct into MDA-MB-435 breast cancer cells to establish stable clones overexpressing either wild-type or mutant IGFBP5. Functional analysis revealed that cells overexpressing wild-type IGFBP5 had significantly lower cell growth rate and motility than the vector-transfected cells, whereas cells overexpressing mutant IGFBP5 demonstrated a significantly higher ability to proliferate and migrate. To illustrate the subcellular localization of the proteins, we generated wild-type and mutant IGFBP5-pDsRed fluorescence fusion constructs. Fluorescence microscopy imaging revealed that mutation of the NLS in IGFBP5 switched the accumulation of IGFBP5 from the nucleus to the cytoplasm of the protein. Together, these findings imply that the mutant form of IGFBP5 increases proliferation and motility of breast cancer cells and that mutation of the NLS in IGFBP5 results in localization of IGFBP5 in the cytoplasm, suggesting that subcellular localization of IGFBP5 affects its cell growth and migration functions in the breast cancer cells

Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians.

Science.gov (United States)

Abnave, Prasad; Aboukhatwa, Ellen; Kosaka, Nobuyoshi; Thompson, James; Hill, Mark A; Aboobaker, A Aziz

2017-10-01

Migration of stem cells underpins the physiology of metazoan animals. For tissues to be maintained, stem cells and their progeny must migrate and differentiate in the correct positions. This need is even more acute after tissue damage by wounding or pathogenic infection. Inappropriate migration also underpins metastasis. Despite this, few mechanistic studies address stem cell migration during repair or homeostasis in adult tissues. Here, we present a shielded X-ray irradiation assay that allows us to follow stem cell migration in planarians. We demonstrate the use of this system to study the molecular control of stem cell migration and show that snail-1 , snail-2 and zeb-1 EMT transcription factor homologs are necessary for cell migration to wound sites and for the establishment of migratory cell morphology. We also observed that stem cells undergo homeostatic migration to anterior regions that lack local stem cells, in the absence of injury, maintaining tissue homeostasis. This requires the polarity determinant notum Our work establishes planarians as a suitable model for further in-depth study of the processes controlling stem cell migration in vivo . © 2017. Published by The Company of Biologists Ltd.

Interrelationship of migration and housing in Slovakia

Directory of Open Access Journals (Sweden)

Peter Sika

2017-10-01

Full Text Available Labour mobility is one of the factors that positively influence the balance of the labor market and employment and thus, economic growth. Milton Friedman, in his speech (1968 to the American Economic Association, communicated that the natural rate of unemployment depends on the degree of labor mobility in the economy. In this article we examine the interdependencies between migration and housing in Slovak Republic. Most residents commute to work in Bratislava and Trnava regions and migration between the other regions is not as pronounced. Low migration of population in Slovak Republic is strongly affected by high percentage of private ownership in the housing sector, which is arresting work force trapped in unemployment. In regions of high unemployment it is also high percentage of dwellings owned by households, affecting possibility of employment in other regions, because they have insufficient income to procure reality in the area with availabale work places as there is no sector of rental housing assuch. Based on the forecasts of the house prices development this status in the next 5 years will not change.

Factors Affecting University Library Website Design

OpenAIRE

Kim, Yongi-Mi; University of Oklahoma

2011-01-01

Existing studies have extensively explored factors that affect users’ intentions to use university library website resources (ULWR); yet little attention has been given to factors affecting university library website design. This paper investigates factors that affect university library website design and assesses the success of the university library website from both designers’ and users’ perspectives. The findings show that when planning a website, university web designers consider univers...

Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing

International Nuclear Information System (INIS)

Zhang, Yong; Yu, Guoyu; Xiang, Yang; Wu, Jianbo; Jiang, Ping; Lee, Wenhui; Zhang, Yun

2010-01-01

Research highlights: → Bm-TFF2 binds to epithelial cells and induces cell migration and wound healing. → Bm-TFF2 suppresses cell apoptosis. → Bm-TFF2 has no effect on cell proliferation. -- Abstract: Toad skin is naked and continually confronted by various injurious factors. Constant skin renewal and repairs occur frequently. However, the mechanisms of the renewal and repair have not clearly elucidated. In our previous work, a trefoil factor (TFF), Bm-TFF2, has been purified from the Bombina maxima skin and characterized as a platelet agonist. The mRNA of TFFs in toad skin was up-regulated greatly during the metamorphosis, indicating a pivotal role of TFFs in amphibian skin. Here, we presented the effects of Bm-TFF2 on the cell migration, apoptosis and proliferation. Bm-TFF2 bound to epithelial cells and showed strong cell motility activity. At the concentrations of 1-100 nM, Bm-TFF2-induced migration of human epithelial AGS and HT-29 cells, and rat intestinal epithelial IEC-6 cell lines. The in vitro wound healing assay also verified the activity of Bm-TFF2. Bm-TFF2 could also inhibit cell apoptosis induced by ceramide and sodium butyrate. The cell migration-promoting activity was abolished by MEK1 inhibitors, U0126 and PD98059, suggesting that ERK1/2 activation is crucial for Bm-TFF2 to stimulate cell migration. Taken together, Bm-TFF2 promoted wound healing by stimulating cell migration via MAPK pathway and preventing cell apoptosis. The potent biological activity of Bm-TFF2 makes it a useful molecular tool for further studies of structure-function relationship of the related human TFFs.

Bm-TFF2, a toad trefoil factor, promotes cell migration, survival and wound healing

Energy Technology Data Exchange (ETDEWEB)

Zhang, Yong [Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223 (China); Graduate School of Chinese Academy of Sciences, Beijing 100049 (China); Yu, Guoyu [Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223 (China); Graduate School of Chinese Academy of Sciences, Beijing 100049 (China); Department of Biochemistry, Kunming Medical College, Kunming, Yunnan 650032 (China); Xiang, Yang [Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223 (China); Graduate School of Chinese Academy of Sciences, Beijing 100049 (China); Wu, Jianbo [Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223 (China); Jiang, Ping [Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223 (China); Graduate School of Chinese Academy of Sciences, Beijing 100049 (China); Lee, Wenhui [Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223 (China); Zhang, Yun, E-mail: zhangy@mail.kiz.ac.cn [Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223 (China)

2010-07-30

Research highlights: {yields} Bm-TFF2 binds to epithelial cells and induces cell migration and wound healing. {yields} Bm-TFF2 suppresses cell apoptosis. {yields} Bm-TFF2 has no effect on cell proliferation. -- Abstract: Toad skin is naked and continually confronted by various injurious factors. Constant skin renewal and repairs occur frequently. However, the mechanisms of the renewal and repair have not clearly elucidated. In our previous work, a trefoil factor (TFF), Bm-TFF2, has been purified from the Bombina maxima skin and characterized as a platelet agonist. The mRNA of TFFs in toad skin was up-regulated greatly during the metamorphosis, indicating a pivotal role of TFFs in amphibian skin. Here, we presented the effects of Bm-TFF2 on the cell migration, apoptosis and proliferation. Bm-TFF2 bound to epithelial cells and showed strong cell motility activity. At the concentrations of 1-100 nM, Bm-TFF2-induced migration of human epithelial AGS and HT-29 cells, and rat intestinal epithelial IEC-6 cell lines. The in vitro wound healing assay also verified the activity of Bm-TFF2. Bm-TFF2 could also inhibit cell apoptosis induced by ceramide and sodium butyrate. The cell migration-promoting activity was abolished by MEK1 inhibitors, U0126 and PD98059, suggesting that ERK1/2 activation is crucial for Bm-TFF2 to stimulate cell migration. Taken together, Bm-TFF2 promoted wound healing by stimulating cell migration via MAPK pathway and preventing cell apoptosis. The potent biological activity of Bm-TFF2 makes it a useful molecular tool for further studies of structure-function relationship of the related human TFFs.

The extracellular adherence protein (Eap) of Staphylococcus aureus acts as a proliferation and migration repressing factor that alters the cell morphology of keratinocytes.

Science.gov (United States)

Eisenbeis, Janina; Peisker, Henrik; Backes, Christian S; Bur, Stephanie; Hölters, Sebastian; Thewes, Nicolas; Greiner, Markus; Junker, Christian; Schwarz, Eva C; Hoth, Markus; Junker, Kerstin; Preissner, Klaus T; Jacobs, Karin; Herrmann, Mathias; Bischoff, Markus

2017-02-01

Staphyloccocus aureus is a major human pathogen and a common cause for superficial and deep seated wound infections. The pathogen is equipped with a large arsenal of virulence factors, which facilitate attachment to various eukaryotic cell structures and modulate the host immune response. One of these factors is the extracellular adherence protein Eap, a member of the "secretable expanded repertoire adhesive molecules" (SERAM) protein family that possesses adhesive and immune modulatory properties. The secreted protein was previously shown to impair wound healing by interfering with host defense and neovascularization. However, its impact on keratinocyte proliferation and migration, two major steps in the re-epithelialization process of wounds, is not known. Here, we report that Eap affects the proliferation and migration capacities of keratinocytes by altering their morphology and adhesive properties. In particular, treatment of non-confluent HaCaT cell cultures with Eap resulted in cell morphology changes as well as a significant reduction in cell proliferation and migration. Eap-treated HaCaT cells changed their appearance from an oblong via a trapezoid to an astral-like shape, accompanied by decreases in cell volume and cell stiffness, and exhibited significantly increased cell adhesion. Eap had a similar influence on endothelial and cancer cells, indicative for a general effect of Eap on eukaryotic cell morphology and functions. Specifically, Eap was found to interfere with growth factor-stimulated activation of the mitogen-activated protein kinase (MAPK) pathway that is known to be responsible for cell shape modulation, induction of proliferation and migration of epithelial cells. Western blot analyses revealed that Eap blocked the phosphorylation of extracellular signal-regulated kinase 1 and 2 (Erk1/2) in keratinocyte growth factor (KGF)-stimulated HaCaT cells. Together, these data add another antagonistic mechanism of Eap in wound healing, whereby the

Socio-cultural and economic factors affecting food consumption patterns in the Arab countries.

Science.gov (United States)

Musaiger, A O

1993-04-01

Several factors have been found to determine the dietary habits of the people in the Arab world. Food consumption pattern has dramatically changed in some Arab countries as a result of sudden increase in income from oil revenue. It is believed that food subsidy policy has adversely affected the food habits in the Gulf states by encouraging the intake of fat, sugar, rice, wheat flour and meat. Socio-cultural factors such as religion, beliefs, food preferences, gender discrimination, education and women's employment all have a noticeable influence on food consumption patterns in this region. Mass media, especially televised food advertisements, play an important role in modifying the dietary habits. The migration movement, particularly that which was carried out during the 70s has a great impact on the food practices in many Arab countries. Comprehensive studies on social, cultural and economic factors associated with food consumption patterns in the Arab region are highly recommended.

Interaction between pre- and post-migration factors on depressive symptoms in new migrants to Hong Kong from Mainland China.

Science.gov (United States)

Chou, Kee-Lee; Wong, Winky K F; Chow, Nelson W S

2011-10-01

The goal of the current study is to examine the role of poor migration planning as a moderator for the effects of two post-migration factors, namely acculturation stress and quality of life, on symptoms of depression. Using a random sample of 347 Hong Kong new migrants from a 1-year longitudinal study, we used multiple regression analyses to examine both the direct and interaction effects of poorly planned migration, acculturation stress, and quality of life on depressive symptoms. Although poorly planned migration did not predict depressive symptoms at 1-year follow-up, it did exacerbate the detrimental effect of the two post-migration factors, namely high stress or low quality of life (both also measured at baseline) on depressive symptoms at this stage. Our results indicate that preventive measures must be developed for new immigrants in Hong Kong, especially for those who were not well prepared for migration.

Sensory basis of lepidopteran migration: Focus on the monarch butterfly

Science.gov (United States)

Guerra, Patrick A.; Reppert, Steven M.

2015-01-01

In response to seasonal habitats, migratory lepidopterans, exemplified by the monarch butterfly, have evolved migration to deal with dynamic conditions. During migration, monarchs use orientation mechanisms, exploiting a time-compensated sun compasses and a light-sensitive inclination magnetic compass to facilitate fall migration south. The sun compass is bidirectional with overwintering coldness triggering the change in orientation direction for remigration northward in the spring. The timing of the remigration and milkweed emergence in the southern US have co-evolved for propagation of the migration. Current research is uncovering the anatomical and molecular substrates that underlie migratory-relevant sensory mechanisms with the antennae being critical components. Orientation mechanisms may be detrimentally affected by environmental factors such as climate change and sensory interference from human-generated sources. PMID:25625216

Differential role of PTEN in transforming growth factor β (TGF-β) effects on proliferation and migration in prostate cancer cells.

Science.gov (United States)

Kimbrough-Allah, Mawiyah N; Millena, Ana C; Khan, Shafiq A

2018-04-01

Transforming growth factor-β (TGF-β) acts as a tumor suppressor in normal epithelial cells but as a tumor promoter in advanced prostate cancer cells. PI3-kinase pathway mediates TGF-β effects on prostate cancer cell migration and invasion. PTEN inhibits PI3-kinase pathway and is frequently mutated in prostate cancers. We investigated possible role(s) of PTEN in TGF-β effects on proliferation and migration in prostate cancer cells. Expression of PTEN mRNA and proteins were determined using RT-PCR and Western blotting in RWPE1 and DU145 cells. We also studied the role of PTEN in TGF-β effects on cell proliferation and migration in DU145 cells after transient silencing of endogenous PTEN. Conversely, we determined the role of PTEN in cell proliferation and migration after over-expression of PTEN in PC3 cells which lack endogenous PTEN. TGF-β1 and TGF-β3 had no effect on PTEN mRNA levels but both isoforms increased PTEN protein levels in DU145 and RWPE1 cells indicating that PTEN may mediate TGF-β effects on cell proliferation. Knockdown of PTEN in DU145 cells resulted in significant increase in cell proliferation which was not affected by TGF-β isoforms. PTEN overexpression in PC3 cells inhibited cell proliferation. Knockdown of endogenous PTEN enhanced cell migration in DU145 cells, whereas PTEN overexpression reduced migration in PC3 cells and reduced phosphorylation of AKT in response to TGF-β. We conclude that PTEN plays a role in inhibitory effects of TGF-β on cell proliferation whereas its absence may enhance TGF-β effects on activation of PI3-kinase pathway and cell migration. © 2018 Wiley Periodicals, Inc.

Effect of shear stress on the migration of hepatic stellate cells.

Science.gov (United States)

Sera, Toshihiro; Sumii, Tateki; Fujita, Ryosuke; Kudo, Susumu

2018-01-01

When the liver is damaged, hepatic stellate cells (HSCs) can change into an activated, highly migratory state. The migration of HSCs may be affected by shear stress due not only to sinusoidal flow but also by the flow in the space of Disse because this space is filled with blood plasma. In this study, we evaluated the effects of shear stress on HSC migration in a scratch-wound assay with a parallel flow chamber. At regions upstream of the wound area, the migration was inhibited by 0.6 Pa and promoted by 2.0 Pa shear stress, compared to the static condition. The platelet-derived growth factor (PDGF)-BB receptor, PDGFR-β, was expressed in all conditions and the differences were not significant. PDGF increased HSC migration, except at 0.6 Pa shear stress, which was still inhibited. These results indicate that another molecular factor, such as PDGFR-α, may act to inhibit the migration under low shear stress. At regions downstream of the wound area, the migration was smaller under shear stress than under the static condition, although the expression of PDGFR-β was significantly higher. In particular, the migration direction was opposite to the wound area under high shear stress; therefore, migration might be influenced by the intercellular environment. Our results indicate that HSC migration was influenced by shear stress intensity and the intercellular environment.

Exploring the factors influencing the cloud computing adoption: a systematic study on cloud migration.

Science.gov (United States)

Rai, Rashmi; Sahoo, Gadadhar; Mehfuz, Shabana

2015-01-01

Today, most of the organizations trust on their age old legacy applications, to support their business-critical systems. However, there are several critical concerns, as maintainability and scalability issues, associated with the legacy system. In this background, cloud services offer a more agile and cost effective platform, to support business applications and IT infrastructure. As the adoption of cloud services has been increasing recently and so has been the academic research in cloud migration. However, there is a genuine need of secondary study to further strengthen this research. The primary objective of this paper is to scientifically and systematically identify, categorize and compare the existing research work in the area of legacy to cloud migration. The paper has also endeavored to consolidate the research on Security issues, which is prime factor hindering the adoption of cloud through classifying the studies on secure cloud migration. SLR (Systematic Literature Review) of thirty selected papers, published from 2009 to 2014 was conducted to properly understand the nuances of the security framework. To categorize the selected studies, authors have proposed a conceptual model for cloud migration which has resulted in a resource base of existing solutions for cloud migration. This study concludes that cloud migration research is in seminal stage but simultaneously it is also evolving and maturing, with increasing participation from academics and industry alike. The paper also identifies the need for a secure migration model, which can fortify organization's trust into cloud migration and facilitate necessary tool support to automate the migration process.

The Relationship Between Post-Migration Stress and Psychological Disorders in Refugees and Asylum Seekers.

Science.gov (United States)

Li, Susan S Y; Liddell, Belinda J; Nickerson, Angela

2016-09-01

Refugees demonstrate high rates of post-traumatic stress disorder (PTSD) and other psychological disorders. The recent increase in forcible displacement internationally necessitates the understanding of factors associated with refugee mental health. While pre-migration trauma is recognized as a key predictor of mental health outcomes in refugees and asylum seekers, research has increasingly focused on the psychological effects of post-migration stressors in the settlement environment. This article reviews the research evidence linking post-migration factors and mental health outcomes in refugees and asylum seekers. Findings indicate that socioeconomic, social, and interpersonal factors, as well as factors relating to the asylum process and immigration policy affect the psychological functioning of refugees. Limitations of the existing literature and future directions for research are discussed, along with implications for treatment and policy.

Factors influencing upon the incidence of seed migration in I-125 seed transperineal prostate implantation

International Nuclear Information System (INIS)

Itami, Jun; Onishi, Kayoko; Kanemura, Mikio

2005-01-01

Transperineal I-125 seed brachytherapy for prostate cancer is rapidly expanding in Japan. Seed migrations to lung and abdomen are well known complication in the seed brachytherapy. The rate of incidence and the predisposing factors were studied. From April 2004 through January 2005, 36 patients underwent transperineal I-125 seed brachytherapy for prostate cancer. In all patients loose I-125 seeds were inserted with Mick applicator according to modified peripheral loading pattern. One day, 1 week, and 1 month after the procedure, posteroanterior and lateral chest X-rays and abdominal X-ray were performed. Abdominal and chest seed migrations were seen in 11 (30.6%) and 14 (38.9%) patients, respectively. In total, 20 patients (55.6%) showed seed migrations. Forty-two I-125 seeds migrated out of 2,508 implanted seeds. Most of the migrations were seen until 1 month after the procedure. The preplanned number of the extraprostatic seeds had a statistically significant influence upon the incidence of seed migration. Seed migration is not a rare phenomenon in transperineal I-125 seed brachytherapy for prostate cancer. To confirm seed migration, X-ray examinations 1 month after the procedure are suited. At the preplanning, the number of extraprostatic seeds should be limited to minimal to decrease the incidence of seed migration. In future, the introduction of linked I-125 seeds is preferred. (author)

Meander morphodynamics over self-formed floodplains: can the migration history affect the future morphology of the river?

Science.gov (United States)

Bogoni, M.; Lanzoni, S.; Putti, M.

2017-12-01

Floodplains, and rivers therein, constitute complex systems whose simulation involves modeling of hydrodynamic, morphodynamic, chemical, and biological processes which act over a wide range of time scales (from days to centuries) and affect each other. Self-formed floodplains are produced by the sedimentary processes associated with the migration of river bends and the formation of abandoned oxbow lakes consequent to the cutoff of mature meanders. The erosion and deposition processes at the banks lead to heterogeneities in the surface composition, thus the river may experience faster or slower migration rates depending on the spatial distribution of the erosional resistance. As a consequence, the past spatial configurations of the river (i.e. the migration history) play a key role in shaping the successive river paths.We recently published a paper addressing the modeling of meander morphodynamics over self-formed heterogeneous floodplain. Results show that the heterogeneity in floodplain composition associated with the formation of geomorphic units (i.e., scroll bars and oxbow lakes) and the choice of a reliable flow field model to drive channel migration are two fundamental ingredients for reproducing correctly the long-term morphodynamics of alluvial meanders. We compare numerically generated planforms obtained for different scenarios of floodplain heterogeneity to natural meandering paths, through half meander metrics and spatial distribution of channel curvatures. Statistical and spectral tools disclose the complexity embedded in meandering geometry and the crucial differences between apparently similar configurations.Floodplain heterogeneity affects both the temporal and spatial distributions of meander geometry, and eventually leads to a closer statistical similarity between simulated and natural planform shapes when scroll bars and oxbow lakes left behind are harder to erode than the surrounding floodplain.

Health Selection, Migration, and HIV Infection in Malawi.

Science.gov (United States)

Anglewicz, Philip; VanLandingham, Mark; Manda-Taylor, Lucinda; Kohler, Hans-Peter

2018-04-27

Despite its importance in studies of migrant health, selectivity of migrants-also known as migration health selection-has seldom been examined in sub-Saharan Africa (SSA). This neglect is problematic because several features of the context in which migration occurs in SSA-very high levels of HIV, in particular-differ from contextual features in regions that have been studied more thoroughly. To address this important gap, we use longitudinal panel data from Malawi to examine whether migrants differ from nonmigrants in pre-migration health, assessed via SF-12 measures of mental and physical health. In addition to overall health selection, we focus on three more-specific factors that may affect the relationship between migration and health: (1) whether migration health selection differs by destination (rural-rural, rural-town, and rural-urban), (2) whether HIV infection moderates the relationship between migration and health, and (3) whether circular migrants differ in pre-migration health status. We find evidence of the healthy migrant phenomenon in Malawi, where physically healthier individuals are more likely to move. This relationship varies by migration destination, with healthier rural migrants moving to urban and other rural areas. We also find interactions between HIV-infected status and health: HIV-infected women moving to cities are physically healthier than their nonmigrant counterparts.

Pre-migration and post-migration factors associated with mental health in humanitarian migrants in Australia and the moderation effect of post-migration stressors: findings from the first wave data of the BNLA cohort study.

Science.gov (United States)

Chen, Wen; Hall, Brian J; Ling, Li; Renzaho, Andre Mn

2017-03-01

The process of becoming a humanitarian migrant is potentially damaging to mental health. We examined the association between pre-migration and post-migration potentially traumatic events and stressors and mental health, and assessed the moderating effect of post-migration stressors in humanitarian migrants in Australia. In this study, we used the first wave of data between 2013 and 2014 from the Building a New Life in Australia survey. The survey included 2399 migrants who had arrived in Australia holding a permanent humanitarian visa 3-6 months preceding the survey, with 77% and 23% of participants being granted visas through offshore and onshore humanitarian programmes, respectively. Post-traumatic stress disorder (PTSD) was measured with the Post-traumatic Stress Disorder 8 items (PTSD-8) and severe mental illness was measured with the Kessler Screening Scale for Psychological Distress (K6). Pre-migration potentially traumatic events and post-migration stressors related to asylum process and resettlement were measured with a self-reported questionnaire. Of the 2399 participants, 762 (31%; 95% CI 29·4-33·2) had PTSD and 394 (16%; 95% CI 14·2-17·2) had severe mental illness. The mean number of pre-migration potentially traumatic events was 2·1 (SD 1·4). 64%, 59%, 49%, and 18% of participants reported poor social integration, economic problems, worrying about family or friends overseas, and loneliness as post-migration stressors. Pre-migration potentially traumatic events and post-migration stressors were positively associated with PTSD and severe mental illness. Factors significantly modifying the association between pre-migration potentially traumatic events and mental health after controlling for confounding factors were resettlement related stressors, including loneliness (odds ratio 1·17, 95% CI 1·05-1·28 for PTSD and 1·28, 1·16-1·41 for severe mental illness) and the number of social integration stressors (1·10, 1·05-1·16 for PTSD). Our data

Factors affecting nuclear development

International Nuclear Information System (INIS)

Stevens, G.H.; Girouard, P.

1995-01-01

Among the factors affecting nuclear development, some depend more or less on public authorities, but many are out of public authorities control (foreign policies, market and deregulation, socials and environmental impacts, public opinion). As far as possible, the following study tries to identify those factors. (D.L.). 2 photos

Factors affecting construction performance: exploratory factor analysis

Science.gov (United States)

Soewin, E.; Chinda, T.

2018-04-01

The present work attempts to develop a multidimensional performance evaluation framework for a construction company by considering all relevant measures of performance. Based on the previous studies, this study hypothesizes nine key factors, with a total of 57 associated items. The hypothesized factors, with their associated items, are then used to develop questionnaire survey to gather data. The exploratory factor analysis (EFA) was applied to the collected data which gave rise 10 factors with 57 items affecting construction performance. The findings further reveal that the items constituting ten key performance factors (KPIs) namely; 1) Time, 2) Cost, 3) Quality, 4) Safety & Health, 5) Internal Stakeholder, 6) External Stakeholder, 7) Client Satisfaction, 8) Financial Performance, 9) Environment, and 10) Information, Technology & Innovation. The analysis helps to develop multi-dimensional performance evaluation framework for an effective measurement of the construction performance. The 10 key performance factors can be broadly categorized into economic aspect, social aspect, environmental aspect, and technology aspects. It is important to understand a multi-dimension performance evaluation framework by including all key factors affecting the construction performance of a company, so that the management level can effectively plan to implement an effective performance development plan to match with the mission and vision of the company.

Glia maturation factor gamma regulates the migration and adherence of human T lymphocytes

Directory of Open Access Journals (Sweden)

Lippert Dustin ND

2012-04-01

Full Text Available Abstract Background Lymphocyte migration and chemotaxis are essential for effective immune surveillance. A critical aspect of migration is cell polarization and the extension of pseudopodia in the direction of movement. However, our knowledge of the underlying molecular mechanisms responsible for these events is incomplete. Proteomic analysis of the isolated leading edges of CXCL12 stimulated human T cell lines was used to identify glia maturation factor gamma (GMFG as a component of the pseudopodia. This protein is predominantly expressed in hematopoietic cells and it has been shown to regulate cytoskeletal branching. The present studies were undertaken to examine the role of GMFG in lymphocyte migration. Results Microscopic analysis of migrating T-cells demonstrated that GMFG was distributed along the axis of movement with enrichment in the leading edge and behind the nucleus of these cells. Inhibition of GMFG expression in T cell lines and IL-2 dependent human peripheral blood T cells with shRNAmir reduced cellular basal and chemokine induced migration responses. The failure of the cells with reduced GMFG to migrate was associated with an apparent inability to detach from the substrates that they were moving on. It was also noted that these cells had an increased adherence to extracellular matrix proteins such as fibronectin. These changes in adherence were associated with altered patterns of β1 integrin expression and increased levels of activated integrins as detected with the activation specific antibody HUTS4. GMFG loss was also shown to increase the expression of the β2 integrin LFA-1 and to increase the adhesion of these cells to ICAM-1. Conclusions The present studies demonstrate that GMFG is a component of human T cell pseudopodia required for migration. The reduction in migration and increased adherence properties associated with inhibition of GMFG expression suggest that GMFG activity influences the regulation of integrin mediated

The urban risk and migration risk factors for schizophrenia: are cats the answer?

Science.gov (United States)

Torrey, E Fuller; Yolken, Robert H

2014-11-01

Being born in and/or raised in an urban area is a proven risk factor for developing schizophrenia. Migrating from countries such as Jamaica or Morocco to countries such as England or the Netherlands is also a proven risk factor for developing schizophrenia. The transmission of Toxoplasma gondii oocysts to children is reviewed and proposed as a partial explanation for both of these risk factors. Copyright © 2014 Elsevier B.V. All rights reserved.

The role of migration-specific and migration-relevant policies in migrant decision-making in transit

NARCIS (Netherlands)

Kuschminder - de Guerre, Katie; Koser, Khalid

2017-01-01

This paper examines the role of migration-specific and migration-relevant policies in migrant decision-making factors for onwards migration or stay in Greece and Turkey. In this paper we distinguish migration-specific policies from migration-relevant policies in transit and destination countries,

Gender and rural-urban migration in China.

Science.gov (United States)

Davin, D

1996-02-01

Many men and women in China are migrating in search of better economic opportunities. Young women who migrate to urban centers in search of opportunity may stay away from their home villages for several years. At some point, however, they are likely to return home. This article considers the effect which such circular migration is having upon gender relations in China. The author's argument is presented in sections on China's 1990 census, migration and the sexual division of labor, migration and child care, the influence of returning migrants, the influence of young female returnees, and the fertility of returnees. She speculates that the demands and expectations of young women who return to their villages after spending some time earning high wages in urban areas will be affected by urban norms. While their return may lead to initial conflict, it is likely that the women will retain greater personal autonomy from their urban experience. Their return is also likely to lead to a higher degree of material consumption in the rural areas. Present circular migration in China has the potential to return human and financial resources to the villages, thereby helping to prevent the urban-rural gap between economic, social, cultural, and educational factors from growing even wider.

Child Migration and Academic Performance: The Case of Basic Education in Ghana

Science.gov (United States)

Tamanja, Emmanuel Makabu J.

2016-01-01

The nexus between migration and academic performance is complex and difficult to extricate. Not only are there several factors affecting academic performance, but also many of these factors are confounding, making it difficult to identify and isolate in order to address. Furthermore, the discourse appears silent on the nexus between child…

Long-term impacts of parental migration on Chinese children's psychosocial well-being: mitigating and exacerbating factors.

Science.gov (United States)

Zhao, Chenyue; Wang, Feng; Li, Leah; Zhou, Xudong; Hesketh, Therese

2017-06-01

Prolonged separation from migrant parents raises concerns for the well-being of 60 million left behind children (LBC) in rural China. This study aimed to investigate the impact of current and previous parental migration on child psychosocial well-being, with a focus on emotional and behavioral outcomes, while considering factors in family care and support. Children were recruited from schools in migrant-sending rural areas in Zhejiang and Guizhou provinces by random stratified sampling. A self-administered questionnaire measured children's psychosocial well-being, demographics, household characteristics, and social support. Multiple linear regression models examined the effects of parental migration and other factors on psychosocial difficulties. Data from 1930 current, 907 previous, and 701 never LBC were included (mean age 12.4, SD 2.1). Adjusted models showed both previous and current parental migration was associated with significantly higher overall psychosocial difficulties, involving aspects of emotion, conduct, peer relationships, hyperactivity, and pro-social behaviors. Parental divorce and lack of available support demonstrated a strong association with greater total difficulties. While children in Guizhou had much worse psychosocial outcomes than those in Zhejiang, adjusted subgroup analysis showed similar magnitude of between-province disparities regardless of parental migration status. However, having divorced parents and lack of support were greater psychosocial risk factors for current and previous-LBC than for never LBC. Parental migration has an independent, long-lasting adverse effect on children. Psychosocial well-being of LBC depends more on the relationship bonds between nuclear family members and the availability of support, rather than socioeconomic status.

Temperature-influenced energetics model for migrating waterfowl

Science.gov (United States)

Aagaard, Kevin; Thogmartin, Wayne E.; Lonsdorg, Eric V.

2018-01-01

Climate and weather affect avian migration by influencing when and where birds fly, the energy costs and risks of flight, and the ability to sense cues necessary for proper navigation. We review the literature of the physiology of avian migration and the influence of climate, specifically temperature, on avian migration dynamics. We use waterfowl as a model guild because of the ready availability of empirical physiological data and their enormous economic value, but our discussion and expectations are broadly generalizable to migratory birds in general. We detail potential consequences of an increasingly warm climate on avian migration, including the possibility of the cessation of migration by some populations and species. Our intent is to lay the groundwork for including temperature effects on energetic gains and losses of migratory birds with the expected consequences of increasing temperatures into a predictive modeling framework. To this end, we provide a simulation of migration progression exclusively focused on the influence of temperature on the physiological determinants of migration. This simulation produced comparable results to empirically derived and observed values for different migratory factors (e.g., body fat content, flight range, departure date). By merging knowledge from the arenas of avian physiology and migratory theory we have identified a clear need for research and have developed hypotheses for a path forward.

Industrial Based Migration in India. A Case Study of Dumdum "Dunlop Industrial Zone"

Science.gov (United States)

Das, Biplab; Bandyopadhyay, Aditya; Sen, Jayashree

2012-10-01

Migration is a very important part in our present society. Basically Millions of people moved during the industrial revolution. Some simply moved from a village to a town in the hope of finding work whilst others moved from one country to another in search of a better way of life. The main reason for moving home during the 19th century was to find work. On one hand this involved migration from the countryside to the growing industrial cities, on the other it involved rates of migration, emigration, and the social changes that were drastically affecting factors such as marriage,birth and death rates. These social changes taking place as a result of capitalism had far ranging affects, such as lowering the average age of marriage and increasing the size of the average family.Migration was not just people moving out of the country, it also invloved a lot of people moving into Britain. In the 1840's Ireland suffered a terrible famine. Faced with a massive cost of feeding the starving population many local landowners paid for labourers to emigrate.There was a shift away from agriculturally based rural dwelling towards urban habitation to meet the mass demand for labour that new industry required. There became great regional differences in population levels and in the structure of their demography. This was due to rates of migration, emigration, and the social changes that were drastically affecting factors such as marriage, birth and death rates. These social changes taking place as a result of capitalism had far ranging affects, such as lowering the average age of marriage and increasing the size of the average family. There is n serious disagreement as to the extent of the population changes that occurred but one key question that always arouses debate is that of whether an expanding population resulted in economic growth or vice versa, i.e. was industrialization a catalyst for population growth? A clear answer is difficult to decipher as the two variables are so

Factors Affecting Medical Service Quality.

Science.gov (United States)

Mosadeghrad, Ali Mohammad

2014-02-01

A better understanding of factors influencing quality of medical service can pinpoint better strategies for quality assurance in medical services. This study aimed to identify factors affecting the quality of medical services provided by Iranian physicians. Exploratory in-depth individual interviews were conducted with sixty-four physicians working in various medical institutions in Iran. Individual, organizational and environmental factors enhance or inhibit the quality of medical services. Quality of medical services depends on the personal factors of the physician and patient, and factors pertaining to the healthcare setting and the broader environment. Differences in internal and external factors such as availability of resources, patient cooperation and collaboration among providers affect the quality of medical services and patient outcomes. Supportive leadership, proper planning, education and training and effective management of resources and processes improve the quality of medical services. This article contributes to healthcare theory and practice by developing a conceptual framework for understanding factors that influence medical services quality.

An examination of the factors fueling migration amongst Community Service practitioners

Directory of Open Access Journals (Sweden)

Candice Reardon

2014-11-01

Aim: The aims were to (1 explore the migration intentions and the factors that influence these intentions amongst Community Service (CS nurses and doctors; (2 explore their views and opinions about the Bilateral Agreement between the UK and South Africa (SA and other UK policies around the recruitment and employment of foreign health professionals; and (3 understand the impact of these policies on the migration plans of these CS doctors and nurses. Method: Qualitative focus groups and interviews were conducted with 23 CS doctors and nurses. To supplement this, 6 interviews were conducted with nurses and a doctor who had worked in the UK. Results: A higher disposition toward moving abroad was apparent amongst those who had experienced a challenging and frustrating CS year. Poor working conditions, including long work hours, high patient loads and inadequate resources and equipment, as well as low salaries and the perceived ambivalence of the government to the complaints of health practitioners, were influencing decisions to migrate abroad. Conclusion: The findings suggest that government efforts to better manage, recognise and respect the work and contribution of health professionals to the country would go a long way toward retaining health professionals.

Examining the Factors Affecting Student Dropout

Directory of Open Access Journals (Sweden)

Fethi Ahmet INAN

2006-07-01

Full Text Available This study examined the factors affecting student dropouts in an online certificate program. In this research, a combination of quantitative and qualitative methods was used. Online Course Dropout Survey was developed and used to determine which factors affect student attrition from the program. The dropout survey was sent by e-mail to 98 students who had dropped the program. Twenty-six students returned the survey. The findings show that the most important factor affecting student retention is finding sufficient time to study. Having personal problems and affordability of the program took second and third place.

Influences of environmental cues, migration history and habitat familiarity on partial migration

DEFF Research Database (Denmark)

Skov, Christian; Aarestrup, Kim; Baktoft, Henrik

2010-01-01

The factors that drive partial migration in organisms are not fully understood. Roach (Rutilus rutilus), a freshwater fish, engage in partial migration where parts of populations switch between summer habitats in lakes and winter habitats in connected streams. To test if the partial migration trait...

Migration among individuals with leprosy: a population-based study in Central Brazil

Directory of Open Access Journals (Sweden)

Christine Murto

2014-03-01

Full Text Available This study investigates social and clinical factors associated with migration among individuals affected by leprosy. A cross-sectional study was conducted among those newly diagnosed with leprosy (2006-2008, in 79 endemic municipalities in the state of Tocantins, Brazil (N = 1,074. In total, 76.2% were born in a municipality different from their current residence. In the five years before diagnosis 16.7% migrated, and 3.6% migrated after leprosy diagnosis. Findings reflect aspects associated with historical rural-urban population movement in Brazil. Indicators of poverty were prominent among before-diagnosis migrants but not after-diagnosis migrants. Migration after diagnosis was associated with prior migration. The association of multibacillary leprosy with migration indicates healthcare access may be an obstacle to early diagnosis among before-diagnosis migrants, which may also be related to the high mobility of this group.

Neuronal Migration and Neuronal Migration Disorder in Cerebral Cortex

OpenAIRE

SUN, Xue-Zhi; TAKAHASHI, Sentaro; GUI, Chun; ZHANG, Rui; KOGA, Kazuo; NOUYE, Minoru; MURATA, Yoshiharu

2002-01-01

Neuronal cell migration is one of the most significant features during cortical development. After final mitosis, neurons migrate from the ventricular zone into the cortical plate, and then establish neuronal lamina and settle onto the outermost layer, forming an "inside-out" gradient of maturation. Neuronal migration is guided by radial glial fibers and also needs proper receptors, ligands, and other unknown extracellular factors, requests local signaling (e.g. some emitted by the Cajal-Retz...

Multiple Weather Factors Affect Apparent Survival of European Passerine Birds

Science.gov (United States)

Salewski, Volker; Hochachka, Wesley M.; Fiedler, Wolfgang

2013-01-01

Weather affects the demography of animals and thus climate change will cause local changes in demographic rates. In birds numerous studies have correlated demographic factors with weather but few of those examined variation in the impacts of weather in different seasons and, in the case of migrants, in different regions. Using capture-recapture models we correlated weather with apparent survival of seven passerine bird species with different migration strategies to assess the importance of selected facets of weather throughout the year on apparent survival. Contrary to our expectations weather experienced during the breeding season did not affect apparent survival of the target species. However, measures for winter severity were associated with apparent survival of a resident species, two short-distance/partial migrants and a long-distance migrant. Apparent survival of two short distance migrants as well as two long-distance migrants was further correlated with conditions experienced during the non-breeding season in Spain. Conditions in Africa had statistically significant but relatively minor effects on the apparent survival of the two long-distance migrants but also of a presumably short-distance migrant and a short-distance/partial migrant. In general several weather effects independently explained similar amounts of variation in apparent survival for the majority of species and single factors explained only relatively low amounts of temporal variation of apparent survival. Although the directions of the effects on apparent survival mostly met our expectations and there are clear predictions for effects of future climate we caution against simple extrapolations of present conditions to predict future population dynamics. Not only did weather explains limited amounts of variation in apparent survival, but future demographics will likely be affected by changing interspecific interactions, opposing effects of weather in different seasons, and the potential for

Determinants of the Egyptian labour migration.

Science.gov (United States)

Kandil, M; Metwally, M

1992-03-01

The objective is to summarize the pattern of Egyptian migration to Arab oil-producing countries (AOPC), to review some factors that are important determinants of labor movement based on theory, and to empirically model the migration rate to AOPC and to Saudi Arabia. Factors are differentiated as to their relative importance. Push factors are the low wages, high inflation rate, and high population density in Egypt; pull factors are higher wages. It is predicted that an increase in income from destination countries has a significant positive impact on the migration rate. An increase in population density stimulates migration. An increase in inflation acts to increase out-migration with a 2-year lag, which accommodates departure preparation. Egypt's experience with labor migration is described for the pre-oil boom, and the post-oil boom. Several estimates of labor migration are given. Government policy toward migration is positive. Theory postulates migration to be determined by differences in the availability of labor, labor rewards between destination and origin, and the cost of migration. In the empirical model, push factors are population density, the current inflation rate, and the ratio of income/capita in AOPC to Egypt. The results indicate that the ratio of income/capita had a strong pull impact and population density had a strong push impact. The inflation rate has a positive impact with a lag estimated at 2 years. Prior to the Camp David Accord, there was a significant decrease in the number of Egyptian migrants due to political tension. The findings support the classical theory of factor mobility. The consequences of migration on the Egyptian economy have been adverse. Future models should disaggregate data because chronic shortages exist in some parts of the labor market. Manpower needs assessment would be helpful for policy makers.

Oceanic migration and spawning of anguillid eels.

Science.gov (United States)

Tsukamoto, K

2009-06-01

Many aspects of the life histories of anguillid eels have been revealed in recent decades, but the spawning migrations of their silver eels in the open ocean still remains poorly understood. This paper overviews what is known about the migration and spawning of anguillid species in the ocean. The factors that determine exactly when anguillid eels will begin their migrations are not known, although environmental influences such as lunar cycle, rainfall and river discharge seem to affect their patterns of movement as they migrate towards the ocean. Once in the ocean on their way to the spawning area, silver eels probably migrate in the upper few hundred metres, while reproductive maturation continues. Although involvement of a magnetic sense or olfactory cues seems probable, how they navigate or what routes they take are still a matter of speculation. There are few landmarks in the open ocean to define their spawning areas, other than oceanographic or geological features such as oceanic fronts or seamounts in some cases. Spawning of silver eels in the ocean has never been observed, but artificially matured eels of several species have exhibited similar spawning behaviours in the laboratory. Recent collections of mature adults and newly spawned preleptocephali in the spawning area of the Japanese eel Anguilla japonica have shown that spawning occurs during new moon periods in the North Equatorial Current region near the West Mariana Ridge. These data, however, show that the latitude of the spawning events can change among months and years depending on oceanographic conditions. Changes in spawning location of this and other anguillid species may affect their larval transport and survival, and appear to have the potential to influence recruitment success. A greater understanding of the spawning migration and the choice of spawning locations by silver eels is needed to help conserve declining anguillid species.

Understanding how emergencies affect internal migration in Costa ...

International Development Research Centre (IDRC) Digital Library (Canada)

2016-06-08

Jun 8, 2016 ... ... under the Latin American and Caribbean Environmental Economics Program ... and, as this research found, will in turn have an impact on migration patterns. ... Balancing trade-offs for wastewater treatment in Mexico City.

The effect of Helicobacter pylori eradication on macrophage migration inhibitory factor, C-reactive protein and fetuin-a levels

Directory of Open Access Journals (Sweden)

Levent Kebapcilar

2010-06-01

Full Text Available OBJECTIVES: To determine the effect of Helicobacter pylori (H. pylori eradication on blood levels of high-sensitivity C-reactive protein (hs-CRP, macrophage migration inhibitory factor and fetuin-A in patients with dyspepsia who are concurrently infected with H. pylori. METHODS: H.pylori infection was diagnosed based on the 14C urea breath test (UBT and histology. Lansoprazole 30 mg twice daily, amoxicillin 1 g twice daily, and clarithromycin 500 mg twice daily were given to all infected patients for 14 days; 14C UBT was then re-measured. In 30 subjects, migration inhibitory factor, fetuin-A and hs-CRP levels were examined before and after the eradication of H. pylori infection and compared to levels in 30 healthy subjects who tested negative for H. pylori infection. RESULTS: Age and sex distribution were comparable between patients and controls. Migration inhibitory factor and hs-CRP levels were higher, and fetuin-A levels were lower, in H. pylori-infected patients (p0.05. CONCLUSION: These findings suggest that H. pylori eradication reduces the levels of pro-inflammatory cytokines such as migration inhibitory factor and hs-CRP and also results in a significant increase in anti-inflammatory markers such as fetuin-A.

Minocycline affects human neutrophil respiratory burst and transendothelial migration.

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Parenti, Astrid; Indorato, Boris; Paccosi, Sara

2017-02-01

This study aimed at investigating the in vitro activity of minocycline and doxycycline on human polymorphonuclear (h-PMN) cell function. h-PMNs were isolated from whole venous blood of healthy subjects; PMN oxidative burst was measured by monitoring ROS-induced oxidation of luminol and transendothelial migration was studied by measuring PMN migration through a monolayer of human umbilical vein endothelial cells. Differences between multiple groups were determined by ANOVA followed by Tukey's multiple comparison test; Student's t test for unpaired data for two groups. Minocycline (1-300 µM) concentration dependently and significantly inhibited oxidative burst of h-PMNs stimulated with 100 nM fMLP. Ten micromolar concentrations, which are superimposable to C max following a standard oral dose of minocycline, promoted a 29.8 ± 4 % inhibition of respiratory burst (P minocycline impaired PMN transendothelial migration, with maximal effect at 100 µM (42.5 ± 7 %, inhibition, n = 5, P minocycline exerted on innate immune h-PMN cell function.

Lack of macrophage migration inhibitory factor in mice does not affect hallmarks of the inflammatory/immune response during the first week after stroke

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Deierborg Tomas

2011-06-01

Full Text Available Abstract Background Macrophage migration inhibitory factor (MIF has been proposed to play a detrimental role in stroke. We recently showed that MIF promotes neuronal death and aggravates neurological deficits during the first week after experimental stroke, in mice. Since MIF regulates tissue inflammation, we studied the putative role of MIF in post-stroke inflammation. Methods We subjected C57BL/6 mice, Mif-/- (MIF-KO or Mif+/+ (WT, to a transient occlusion of the right middle cerebral artery (tMCAo or sham-surgery. We studied MIF expression, GFAP expression and the number of CD74-positive cells in the ischemic brain hemisphere 7 days after tMCAo using primarily immunohistochemistry. We determined IFN-γ, IL-2, IL-4, IL-5, IL-10, IL-12, KC/CXCL-1 and TNF-α protein levels in the brain (48 h after surgery and serum (48 h and 7 days after surgery by a multiplex immunoassay. Results We observed that MIF accumulates in neurons and astrocytes of the peri-infarct region, as well as in microglia/macrophages of the infarct core up to 7 days after stroke. Among the inflammatory mediators analyzed, we found a significant increase in cerebral IL-12 and KC levels after tMCAo, in comparison to sham-surgery. Importantly, the deletion of Mif did not significantly affect the levels of the cytokines evaluated, in the brain or serum. Moreover, the spleen weight 48 h and 7 days subsequent to tMCAo was similar in WT and MIF-KO mice. Finally, the extent of GFAP immunoreactivity and the number of MIF receptor (CD74-positive cells within the ischemic brain hemisphere did not differ significantly between WT and MIF-KO mice subjected to tMCAo. Conclusions We conclude that MIF does not affect major components of the inflammatory/immune response during the first week after experimental stroke. Based on present and previous evidence, we propose that the deleterious MIF-mediated effects in stroke depend primarily on an intraneuronal and/or interneuronal action.

Rural migration in Nevada: Lincoln County

International Nuclear Information System (INIS)

Soden, D.L.; Carns, D.E.; Mosser, D.; Conary, J.S.; Ansell, J.P.

1993-01-01

The principal objective of this project was to develop insight into the scope of migration of working age Nevadans out of their county of birth; including the collection of data on their skill levels, desire to out or in-migrate, interactions between families of migratory persons, and the impact that the proposed high-level nuclear waste repository at Yucca mountain might have on their individual, and collective, decisions to migrate and return. The initial phase of this project reported here was conducted in 1992 and 1993 in Lincoln County, Nevada, one of the counties designated as ''affected'' by the proposed repository program. The findings suggest that a serious out-migration problem in Lincoln County, and that the Yucca mountain project will likely affect decisions relating to migration patterns in the future

Why are you draining your brain? Factors underlying decisions of graduating Lebanese medical students to migrate.

Science.gov (United States)

Akl, Elie A; Maroun, Nancy; Major, Stella; Afif, Claude; Chahoud, Bechara; Choucair, Jacques; Sakr, Mazen; Schünemann, Holger J

2007-03-01

In the context of a worldwide physician brain drain phenomenon, Lebanon has the highest emigration factor in the Middle East and North Africa. In this manuscript we aim to identify and develop a conceptual framework for the factors underlying the decisions of graduating Lebanese medical students to train abroad. We conducted two focus groups and seven semi-structured individual interviews with 23 students. In the deductive analysis (based on the push-pull theory), students reported push factors in Lebanon and pull factors abroad related to five dimensions. They focused predominantly on how training abroad provides them with a competitive advantage in an oversaturated Lebanese job market. An inductive analysis revealed the following emerging concepts: repel factors abroad and retain factors locally; societal expectations that students should train abroad; marketing of abroad training; and an established culture of migration. The marketing of abroad training and the culture of migration are prevalent in the academic institutions.

Important processes affecting the release and migration of radionuclides from a deep geological repository

International Nuclear Information System (INIS)

Barátová, Dana; Nečas, Vladimír

2017-01-01

The processes that affect significantly the transport of contaminants through the near field and far field of a deep geological repository of spent nuclear fuel were studied. The processes can be generally divided into (i) processes related to the release of radionuclides from the spent nuclear fuel; (ii) processes related to the radionuclide transport mechanisms (such as advection and diffusion); and (iii) processes affecting the rate of radionuclide migration through the multi-barrier repository system. A near-field and geosphere model of an unspecified geological repository sited in a crystalline rock is also described. Focus of the treatment is on the effects of the different processes on the activity flow of the major safety-relevant radionuclides. The activity flow was simulated for one spent fuel cask by using the GoldSim simulation tool. (orig.)

Expression of macrophage migration inhibitory factor and CD74 in the inner ear and middle ear in lipopolysaccharide-induced otitis media.

Science.gov (United States)

Ishihara, Hisashi; Kariya, Shin; Okano, Mitsuhiro; Zhao, Pengfei; Maeda, Yukihide; Nishizaki, Kazunori

2016-10-01

Significant expression of macrophage migration inhibitory factor and its receptor (CD74) was observed in both the middle ear and inner ear in experimental otitis media in mice. Modulation of macrophage migration inhibitory factor and its signaling pathway might be useful in the management of inner ear inflammation due to otitis media. Inner ear dysfunction secondary to otitis media has been reported. However, the specific mechanisms involved are not clearly understood. The aim of this study is to investigate the expression of macrophage migration inhibitory factor and CD74 in the middle ear and inner ear in lipopolysaccharide-induced otitis media. BALB/c mice received a transtympanic injection of either lipopolysaccharide or phosphate-buffered saline (PBS). The mice were sacrificed 24 h after injection, and temporal bones were processed for polymerase chain reaction (PCR) analysis, histologic examination, and immunohistochemistry. PCR examination revealed that the lipopolysaccharide-injected mice showed a significant up-regulation of macrophage migration inhibitory factor in both the middle ear and inner ear as compared with the PBS-injected control mice. The immunohistochemical study showed positive reactions for macrophage migration inhibitory factor and CD74 in infiltrating inflammatory cells, middle ear mucosa, and inner ear in the lipopolysaccharide-injected mice.

Fisetin inhibits epidermal growth factor-induced migration of ARPE-19 cells by suppression of AKT activation and Sp1-dependent MMP-9 expression.

Science.gov (United States)

Lin, Hung-Yu; Chen, Yong-Syuan; Wang, Kai; Chien, Hsiang-Wen; Hsieh, Yi-Hsien; Yang, Shun-Fa

2017-01-01

Proliferative vitreoretinopathy (PVR) can result in abnormal migration of RPE cells. Fisetin is a naturally occurring compound that has been reported to have antitumor effects, but its effects on epidermal growth factor (EGF)-induced cell migration and the underlying mechanisms remain unclear. Effects of fisetin on EGF-induced cell viability and migration were examined with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and in vitro migration assays. Reverse transcription-PCR (RT-PCR) and immunoblotting were performed to evaluate matrix metallopeptidase-9 (MMP-9) expression and activation of specificity protein-1 (Sp1) and protein kinase B (AKT) in ARPE-19 cells treated with EGF and with or without fisetin. Luciferase and chromatin immunoprecipitation (ChIP) assays were performed to examine Sp1 transcription activity and MMP-9 binding activity. Fisetin did not affect ARPE-19 cell viability and significantly inhibited the EGF-induced migration capacity of ARPE-19 cells. Furthermore, fisetin exerted an antimigratory effect and suppressed MMP-9 mRNA and protein expression. Treatment with EGF induced phosphorylation of AKT and expression of MMP-9 and Sp1. Fisetin combined with LY294002 (an inhibitor of AKT) prevented the EGF-induced migration involved in downregulation of Sp1 and MMP-9 expression. Luciferase and ChIP assays suggested that fisetin remarkably decreased the EGF-induced transcription activity of MMP-9 and Sp1 and inhibited EGF-mediated Sp1 from directly binding to the MMP-9 promoter in ARPE-19 cells. Fisetin inhibited EGF-induced cell migration via modulation of AKT/Sp1-dependent MMP-9 transcriptional activity. Therefore, fisetin may be a potential agent in the treatment of migratory PVR diseases.

NAFTA: The Mexican Economy, and Undocumented Migration

Science.gov (United States)

2011-10-28

NAFTA contributed to modest increases in Mexican formal employment since 1994. Since employment constitutes one of the chief factors affecting poverty...any other provision of law , no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a...FINAL 3. DATES COVERED (From - To) 4. TITLE AND SUBTITLE NAFTA , the Mexican Economy, and Undocumented Migration 5a

Cyclone Aila, livelihood stress, and migration: empirical evidence from coastal Bangladesh.

Science.gov (United States)

Saha, Sebak Kumar

2017-07-01

This paper investigates why households migrated as a unit to Khulna City from the affected Upazilas of Dacope and Koyra in Khulna District, Bangladesh, following Cyclone Aila on 25 May 2009. The study reveals that households migrated primarily because of the livelihood stress that resulted from the failure to derive a secure income like before the event from the impacted areas-other push and pull factors also played a part in their migration decision. Despite all of the Aila-induced losses and problems, all households wanted to avoid migration, but they were unable to do so for this principal reason. The findings also demonstrate that, if livelihoods cannot be restored, some form of widespread migration is inevitable after a disaster such as this one. In addition, they show that migration has the potential to serve as a key adaptive response to environmental events, as evidenced by the improved economic conditions of a substantial number of the migrated households. © 2017 The Author(s). Disasters © Overseas Development Institute, 2017.

RNAi Knockdown of Hypoxia-Inducible Factor-1α Decreased the Proliferation, Migration, and Invasion of Hypoxic Hepatocellular Carcinoma Cells.

Science.gov (United States)

Chen, ChengShi; Liu, Rong; Wang, JianHua; Yan, ZhiPing; Qian, Sheng; Zhang, Wei

2015-04-01

The obstruction of hepatic arterial blood flow results in tumor tissue hypoxia and elevated expression of hypoxia-inducible factor-1alpha (HIF-1α). Our study evaluated whether lentivirus-mediated short interference RNA against HIF-1α inhibits proliferation, invasion, and migration of hepatocellular carcinoma (HCC) cells under hypoxia. RNA interference knockdown of HIF-1α was achieved by HIF-1α-directed lentiviral shRNA, in a rat HCC cell line cultured under hypoxia condition for varying length of times. The expression levels of HIF-1α and vascular endothelial growth factor were examined using reverse transcription polymerase chain reaction and western blot analyses. Cell proliferation, migration, and invasion were measured by cell viability, transwell migration, and invasion assays, respectively. Inhibition of HIF-1α expression by shRNA suppressed vascular endothelial growth factor mRNA and protein levels under both normoxia and hypoxia. It also suppressed cell migration and invasion, which were enhanced under hypoxic conditions. RNAi knockdown of HIF-1α further suppressed hypoxia-mediated inhibition of the cell proliferation. These data suggest that shRNA of HIF-1α could antagonize the hypoxia-mediated increase in hepatic cancer cell migration and invasion, and synergize with hypoxia to inhibit the cell proliferation in HCC cells.

Curcumin modulates endothelial permeability and monocyte transendothelial migration by affecting endothelial cell dynamics.

Science.gov (United States)

Monfoulet, Laurent-Emmanuel; Mercier, Sylvie; Bayle, Dominique; Tamaian, Radu; Barber-Chamoux, Nicolas; Morand, Christine; Milenkovic, Dragan

2017-11-01

Curcumin is a phenolic compound that exhibits beneficial properties for cardiometabolic health. We previously showed that curcumin reduced the infiltration of immune cells into the vascular wall and prevented atherosclerosis development in mice. This study aimed to investigate the effect of curcumin on monocyte adhesion and transendothelial migration (TEM) and to decipher the underlying mechanisms of these actions. Human umbilical vein endothelial cells (HUVECs) were exposed to curcumin (0.5-1μM) for 3h prior to their activation by Tumor Necrosis Factor alpha (TNF-α). Endothelial permeability, monocyte adhesion and transendothelial migration assays were conducted under static condition and shear stress that mimics blood flow. We further investigated the impact of curcumin on signaling pathways and on the expression of genes using macroarrays. Pre-exposure of endothelial cells to curcumin reduced monocyte adhesion and their transendothelial migration in both static and shear stress conditions. Curcumin also prevented changes in both endothelial permeability and the area of HUVECs when induced by TNF-α. We showed that curcumin modulated the expression of 15 genes involved in the control of cytoskeleton and endothelial junction dynamic. Finally, we showed that curcumin inhibited NF-κB signaling likely through an antagonist interplay with several kinases as suggested by molecular docking analysis. Our findings demonstrate the ability of curcumin to reduce monocyte TEM through a multimodal regulation of the endothelial cell dynamics with a potential benefit on the vascular endothelial function barrier. Copyright © 2017 Elsevier Inc. All rights reserved.

Proneural Transcription Factors Regulate Different Steps of Cortical Neuron Migration through Rnd-Mediated Inhibition of RhoA Signaling

Science.gov (United States)

Pacary, Emilie; Heng, Julian; Azzarelli, Roberta; Riou, Philippe; Castro, Diogo; Lebel-Potter, Mélanie; Parras, Carlos; Bell, Donald M.; Ridley, Anne J.; Parsons, Maddy; Guillemot, François

2011-01-01

Summary Little is known of the intracellular machinery that controls the motility of newborn neurons. We have previously shown that the proneural protein Neurog2 promotes the migration of nascent cortical neurons by inducing the expression of the atypical Rho GTPase Rnd2. Here, we show that another proneural factor, Ascl1, promotes neuronal migration in the cortex through direct regulation of a second Rnd family member, Rnd3. Both Rnd2 and Rnd3 promote neuronal migration by inhibiting RhoA signaling, but they control distinct steps of the migratory process, multipolar to bipolar transition in the intermediate zone and locomotion in the cortical plate, respectively. Interestingly, these divergent functions directly result from the distinct subcellular distributions of the two Rnd proteins. Because Rnd proteins also regulate progenitor divisions and neurite outgrowth, we propose that proneural factors, through spatiotemporal regulation of Rnd proteins, integrate the process of neuronal migration with other events in the neurogenic program. PMID:21435554

Thalidomide increases human keratinocyte migration and proliferation.

Science.gov (United States)

Nasca, M R; O'Toole, E A; Palicharla, P; West, D P; Woodley, D T

1999-11-01

Thalidomide is reported to have therapeutic utility in the treatment of pyoderma gangrenosum, Behçet's disease, aphthous ulcers, and skin wounds. We investigated the effect of thalidomide on human keratinocyte proliferation and migration, two early and critical events in the re-epithelialization of skin wounds. Thalidomide at concentrations less than 1 microM did not affect keratinocyte viability. Using a thymidine incorporation assay, we found that thalidomide, at therapeutic concentrations, induced more than a 2. 5-fold increase in the proliferative potential of the cells. Keratinocyte migration was assessed by two independent motility assays: a colloidal gold assay and an in vitro scratch assay. At optimal concentrations, thalidomide increased keratinocyte migration on a collagen matrix more than 2-fold in the colloidal gold assay and more than 3-fold in the scratch assay over control. Although pro-migratory, thalidomide did not alter the level of metalloproteinase-9 secreted into culture medium. Thalidomide did, however, induce a 2-4-fold increase in keratinocyte-derived interleukin-8, a pro-migratory cellular autocrine factor. Human keratinocyte migration and proliferation are essential for re-epithelialization of skin wounds. Interleukin-8 increases human keratinocyte migration and proliferation and is chemotactic for keratinocytes. Therefore, thalidomide may modulate keratinocyte proliferation and motility by a chemokine-dependent pathway.

Long-term relationship between climate change and nomadic migration in historical China

Directory of Open Access Journals (Sweden)

Qing Pei

2014-06-01

Full Text Available We investigated the relationship between a 2000-year history of nomadic migration and climate change in historical China. By using updated data and statistical methods, the study solved several unanswered questions from past research about the relationship between climate change and the nomadic migration, especially over the long term and on a large spatial scale. The study used correlation analysis, multiple regression analysis, and Granger causality analysis to quantitatively verify the following causal pathway: climate change â†' nomadic migration â†' conflicts between pastoralists and agriculturalists. In the long term, precipitation was a statistically more influential factor on nomadic migration than temperature in historical China. How climate change affects the migration of nomadic minorities in the long term is theoretically explained based on the Push-Pull model as well as statistical evidence.

How social structure changes in Chinese global cities: Synthesizing globalization, migration and institutional factors in Beijing

NARCIS (Netherlands)

Shi, Q.; Liu, T.; Musterd, S.; Cao, G.

2017-01-01

Recent studies on the social structural change in global cities have recognized globalization, migration, and institutional factors as three main forces underlying this process. However, effects of these factors have rarely been synthetically examined and the social structure of emerging Chinese

Low Calorie Diet Affects Aging-Related Factors

Science.gov (United States)

... Current Issue Past Issues Research News From NIH Low Calorie Diet Affects Aging-Related Factors Past Issues / ... to learn more about the effects of sustained low-calorie diets in humans on factors affecting aging. ...

Outward migration may alter population dynamics and income inequality

Science.gov (United States)

Shayegh, Soheil

2017-11-01

Climate change impacts may drive affected populations to migrate. However, migration decisions in response to climate change could have broader effects on population dynamics in affected regions. Here, I model the effect of climate change on fertility rates, income inequality, and human capital accumulation in developing countries, focusing on the instrumental role of migration as a key adaptation mechanism. In particular, I investigate how climate-induced migration in developing countries will affect those who do not migrate. I find that holding all else constant, climate change raises the return on acquiring skills, because skilled individuals have greater migration opportunities than unskilled individuals. In response to this change in incentives, parents may choose to invest more in education and have fewer children. This may ultimately reduce local income inequality, partially offsetting some of the damages of climate change for low-income individuals who do not migrate.

An insight into the nature of the relationship between migration and entrepreneurship

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Alin Croitoru

2013-06-01

Full Text Available Having as starting point a research field within the Romanian immigrant community from Graz, this paper assumes two ambitious objectives. Firstly, the article highlights some of the features of Romanian migration to Austria, an under-researched country of destination. Secondly, the paper attempts to supply a brief introduction into a very broad topic, namely the relationship between migration and entrepreneurship. Here we also attempt an understanding of how individuals’ experience of international migration affects their propensity to entrepreneurial behaviors. The concept of entrepreneurship follows the lines described by Austrian economics which allows for a deeper insight into the individuals subjective perspectives on stimulating and inhibiting factors for entrepreneurship.

Towards healthy migration: an exploratory study on the resilience of migrant domestic workers from the Philippines

NARCIS (Netherlands)

van der Ham, A.J.; Ujano-Batangan, M.T.; Ignacio, R.; Wolffers, I.N.

2014-01-01

Domestic workers face many migration-related stressors that affect their mental health. Currently there is an emphasis in the literature on these workers' problems and vulnerability, while there is little insight into factors that positively affect their mental health. In this study, we describe a

Migration trends of Sockeye Salmon at the northern edge of their distribution

Science.gov (United States)

Carey, Michael P.; Zimmerman, Christian E.; Keith, Kevin D.; Schelske, Merlyn; Lean, Charles; Douglas, David C.

2017-01-01

Climate change is affecting arctic and subarctic ecosystems, and anadromous fish such as Pacific salmon Oncorhynchus spp. are particularly susceptible due to the physiological challenge of spawning migrations. Predicting how migratory timing will change under Arctic warming scenarios requires an understanding of how environmental factors drive salmon migrations. Multiple mechanisms exist by which environmental conditions may influence migrating salmon, including altered migration cues from the ocean and natal river. We explored relationships between interannual variability and annual migration timing (2003–2014) of Sockeye Salmon O. nerka in a subarctic watershed with environmental conditions at broad, intermediate, and local spatial scales. Low numbers of Sockeye Salmon have returned to this high-latitude watershed in recent years, and run size has been a dominant influence on the migration duration and the midpoint date of the run. The duration of the migration upriver varied by as much as 25 d across years, and shorter run durations were associated with smaller run sizes. The duration of the migration was also extended with warmer sea surface temperatures in the staging area and lower values of the North Pacific Index. The midpoint date of the total run was earlier when the run size was larger, whereas the midpoint date was delayed during years in which river temperatures warmed earlier in the season. Documenting factors related to the migration of Sockeye Salmon near the northern limit of their range provides insights into the determinants of salmon migrations and suggests processes that could be important for determining future changes in arctic and subarctic ecosystems.

Japanese migration in contemporary Japan: economic segmentation and interprefectural migration.

Science.gov (United States)

Fukurai, H

1991-01-01

This paper examines the economic segmentation model in explaining 1985-86 Japanese interregional migration. The analysis takes advantage of statistical graphic techniques to illustrate the following substantive issues of interregional migration: (1) to examine whether economic segmentation significantly influences Japanese regional migration and (2) to explain socioeconomic characteristics of prefectures for both in- and out-migration. Analytic techniques include a latent structural equation (LISREL) methodology and statistical residual mapping. The residual dispersion patterns, for instance, suggest the extent to which socioeconomic and geopolitical variables explain migration differences by showing unique clusters of unexplained residuals. The analysis further points out that extraneous factors such as high residential land values, significant commuting populations, and regional-specific cultures and traditions need to be incorporated in the economic segmentation model in order to assess the extent of the model's reliability in explaining the pattern of interprefectural migration.

Role of macrophage migration inhibitory factor (MIF in allergic and endotoxin-induced airway inflammation in mice

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M. Korsgren

2000-01-01

Full Text Available Macrophage migration inhibitory factor (MIF has recently been forwarded as a critical regulator of inflammatory conditions, and it has been hypothesized that MIF may have a role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD. Hence, we examined effects of MIF immunoneutralization on the development of allergen-induced eosinophilic inflammation as well as on lipopolysaccaride (LPS-induced neutrophilic inflammation in lungs of mice. Anti-MIF serum validated with respect to MIF neutralizing capacity or normal rabbit serum (NRS was administered i.p. repeatedly during allergen aerosol exposure of ovalbumin (OVA-immunized mice in an established model of allergic asthma, or once before instillation of a minimal dose of LPS into the airways of mice, a tentative model of COPD. Anti-MIF treatment did not affect the induced lung tissue eosinophilia or the cellular composition of bronchoalveolar lavage fluid (BALF in the asthma model. Likewise, anti-MIF treatment did not affect the LPS-induced neutrophilia in lung tissue, BALF, or blood, nor did it reduce BALF levels of tumor necrosis factor-α (TNF-α and macrophage inflammatory protein–1 α (MIP–1 α. The present data suggest that MIF is not critically important for allergen-induced eosinophilic, and LPS-induced neutrophilic responses in lungs of mice. These findings do not support a role of MIF inhibition in the treatment of inflammatory respiratory diseases.

Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation.

LENUS (Irish Health Repository)

Wakai, A

2012-02-03

The effects of adenosine on neutrophil (polymorphonuclear neutrophils; PMN)-directed changes in vascular permeability are poorly characterized. This study investigated whether adenosine modulates activated PMN vascular endothelial growth factor (vascular permeability factor; VEGF) release and transendothelial migration. PMN activated with tumour necrosis factor-alpha (TNF-alpha, 10 ng\\/mL) were incubated with adenosine and its receptor-specific analogues. Culture supernatants were assayed for VEGF. PMN transendothelial migration across human umbilical vein endothelial cell (HUVEC) monolayers was assessed in vitro. Adhesion molecule receptor expression was assessed flow cytometrically. Adenosine and some of its receptor-specific analogues dose-dependently inhibited activated PMN VEGF release. The rank order of potency was consistent with the affinity profile of human A2B receptors. The inhibitory effect of adenosine was reversed by 3,7-dimethyl-1-propargylxanthine, an A2 receptor antagonist. Adenosine (100 microM) or the A2B receptor agonist 5\\'-N-ethylcarboxamidoadenosine (NECA, 100 microM) significantly reduced PMN transendothelial migration. However, expression of activated PMN beta2 integrins and HUVEC ICAM-1 were not significantly altered by adenosine or NECA. Adenosine attenuates human PMN VEGF release and transendothelial migration via the A2B receptor. This provides a novel target for the modulation of PMN-directed vascular hyperpermeability in conditions such as the capillary leak syndrome.

Plasma rich in growth factors (PRGF-Endoret) stimulates tendon and synovial fibroblasts migration and improves the biological properties of hyaluronic acid.

Science.gov (United States)

Anitua, E; Sanchez, M; De la Fuente, M; Zalduendo, M M; Orive, G

2012-09-01

Cell migration plays an essential role in development, wound healing, and tissue regeneration. Plasma rich in growth factors (PRGF-Endoret) technology offers a potential source of growth factors involved in tissue regeneration. Here, we evaluate the potential of PRGF-Endoret over tendon cells and synovial fibroblasts migration and study whether the combination of this autologous technology with hyaluronic acid (HA) improves the effect and potential of the biomaterials over the motility of both types of fibroblasts. Migration of primary tendon cells and synovial fibroblasts after culturing with either PRGF or PPGF (plasma poor in growth factors) at different doses was evaluated. Furthermore, the migratory capacity induced by the combination of PPGF and PRGF with HA was tested. PPGF stimulated migration of both types of cells but this effect was significantly higher when PRGF was used. Tendon cells showed an increase of 212% in migratory ability when HA was combined with PPGF and of 335% in the case of HA + PRGF treatment compared with HA alone. PRGF-Endoret stimulates migration of tendon cells and synovial fibroblasts and improves the biological properties of HA.

Health professionals' migration in emerging market economies: patterns, causes and possible solutions.

Science.gov (United States)

Nair, Manisha; Webster, Premila

2013-03-01

About a third of the countries affected by shortage of human resources for health are the emerging market economies (EMEs). The greatest shortage in absolute terms was found to be in India and Indonesia leading to health system crisis. This review identifies the patterns of migration of health workers, causes and possible solutions in these EMEs. A qualitative synthesis approach based on the 'critical review' and 'realist review' approaches to the literature review was used. The patterns of migration of health professionals' in the EMEs have led to two types of discrepancies between health needs and healthcare workers: (i) within country (rural-urban, public-private or government healthcare sector-private sector) and (ii) across countries (south to north). Factors that influence migration include lack of employment opportunities, appropriate work environment and wages in EMEs, growing demand in high-income countries due to demographic transition, favourable country policies for financial remittances by migrant workers and medical education system of EMEs. A range of successful national and international initiatives to address health workforce migration were identified. Measures to control migration should be country specific and designed in accordance with the push and pull factors existing in the EMEs.

Factors affecting dispersion of radionuclides in north western coast of Mediterranean Sea, Egypt

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E.R. Atta

2015-01-01

Full Text Available This study aims to analyze the principal factors affecting the interaction of 137Cs, 60Co and 89Sr with coastal sediments and their importance for migration of these ions in surface water. The second goal is to assess the acceptability of radiological consequences of proposed routine discharges of nuclear installations for radioactive materials into surface water as well as to confirm the suitability of the site to select and to establish limits for radioactive discharge into water. Uptake of the investigated ions by Mediterranean Sea bottom sediment samples have been studied as a function of liquid to solid ratio (V/m and contact time using batch technique. The suspended sediment concentration, different discharge rates of radionuclides and the distance between the source point in the sea and the beach were investigated. The obtained results show that Kd of Cs+, Co2+ and Sr2+is 20, 32 and 10 l/g, respectively. The lowest effective dose is for 89Sr, while the highest effective dose is for 137Cs, at the same distances. A mathematical model for the migration of the investigated isotopes in surface water was constructed to predict the concentration of these ions for both different distances and time periods.

Factors Affecting University Library Website Design

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Yongi-Mi Kim

2011-09-01

Full Text Available Existing studies have extensively explored factors that affect users’ intentions to use university library website resources (ULWR; yet little attention has been given to factors affecting university library website design. This paper investigates factors that affect university library website design and assesses the success of the university library website from both designers’ and users’ perspectives. The findings show that when planning a website, university web designers consider university guidelines, review other websites, and consult with experts and other divisions within the library; however, resources and training for the design process are lacking. While website designers assess their websites as highly successful, user evaluations are somewhat lower. Accordingly, use is low, and users rely heavily on commercial websites. Suggestions for enhancing the usage of ULWR are provided.

Migration intentions of Ghanaian medical students: the influence of existing funding mechanisms of medical education ("the fee factor").

Science.gov (United States)

Eliason, S; Tuoyire, D A; Awusi-Nti, C; Bockarie, A S

2014-06-01

To explore the effects of fee paying status on migration intentions of Ghanaian medical students. Cross sectional questionnaire based survey. All established Ghanaian medical schools with students in their clinical years. Fee-paying and non-fee-paying Ghanaian medical students in their clinical years. None. Migration intentions of Ghanaian medical students after graduation, Allegiance to Government of Ghana. Approximately half (49%) of the medical students surveyed had intentions of migrating after school. Over 48% of those with migration intentions plan on doing so immediately after completing their house job, while 44% plan to migrate at least one year after their house job. The most popular destination chosen by the potential migrant doctors was North America (38%). Fee-paying students were significantly more likely (OR=2.11, CI=1.32, 3.38) than non-fee-paying students to have intentions of migrating after their training. Secondly, fee-paying students were more likely (OR=9.66, CI=4.42, 21.12) than non-fee paying students to feel they owe no allegiance to the Government of Ghana because of their fee-paying status. Medical Students' fee-paying status affects their intentions to migrate and their allegiance to the country after completion of their training.

Vascular endothelial growth factor receptor-1 mediates migration of human colorectal carcinoma cells by activation of Src family kinases

Science.gov (United States)

Lesslie, D P; Summy, J M; Parikh, N U; Fan, F; Trevino, J G; Sawyer, T K; Metcalf, C A; Shakespeare, W C; Hicklin, D J; Ellis, L M; Gallick, G E

2006-01-01

Vascular endothelial growth factor (VEGF) is the predominant pro-angiogenic cytokine in human malignancy, and its expression correlates with disease recurrence and poor outcomes in patients with colorectal cancer. Recently, expression of vascular endothelial growth factor receptors (VEGFRs) has been observed on tumours of epithelial origin, including those arising in the colon, but the molecular mechanisms governing potential VEGF-driven biologic functioning in these tumours are not well characterised. In this report, we investigated the role of Src family kinases (SFKs) in VEGF-mediated signalling in human colorectal carcinoma (CRC) cell lines. Vascular endothelial growth factor specifically activated SFKs in HT29 and KM12L4 CRC cell lines. Further, VEGF stimulation resulted in enhanced cellular migration, which was effectively blocked by pharmacologic inhibition of VEGFR-1 or Src kinase. Correspondingly, migration studies using siRNA clones with reduced Src expression confirmed the requirement for Src in VEGF-induced migration in these cells. Furthermore, VEGF treatment enhanced VEGFR-1/SFK complex formation and increased tyrosine phosphorylation of focal adhesion kinase, p130 cas and paxillin. Finally, we demonstrate that VEGF-induced migration is not due, at least in part, to VEGF acting as a mitogen. These results suggest that VEGFR-1 promotes migration of tumour cells through a Src-dependent pathway linked to activation of focal adhesion components that regulate this process. PMID:16685275

Factors influencing the spawning migration of female anadromous brown trout

DEFF Research Database (Denmark)

Svendsen, Jon Christian; Koed, Anders; Aarestrup, Kim

2004-01-01

Radio telemetry was employed to study movements of adult female anadromous brown trout Salmo trutta (sea trout) during upstream spawning migration and following spawning in a stream with tributaries. Sea trout were monitored by manual tracking and by automatic listening stations. The latter...... suggested that initiation of upstream migration was positively correlated with stream discharge. Individual sea trout performed repeated upstream migration 'initiations' (visits) to areas where they were detected by the automatic listening stations. The first and subsequent upstream migration 'initiations...

Dynamic Quantification of Host Schwann Cell Migration into Peripheral Nerve Allografts

Science.gov (United States)

Whitlock, Elizabeth L.; Myckatyn, Terence M.; Tong, Alice Y.; Yee, Andrew; Yan, Ying; Magill, Christina K.; Johnson, Philip J.; Mackinnon, Susan E.

2010-01-01

Host Schwann cell (SC) migration into nerve allografts is the limiting factor in the duration of immunosuppression following peripheral nerve allotransplantation, and may be affected by different immunosuppressive regimens. Our objective was to compare SC migration patterns between clinical and experimental immunosuppression regimens both over time and at the harvest endpoint. Eighty mice that express GFP under the control of the Schwann cell specific S100 promoter were engrafted with allogeneic, nonfluorescent sciatic nerve grafts. Mice received immunosuppression with either tacrolimus (FK506), or experimental T-cell triple costimulation blockade (CSB), consisting of CTLA4-immunoglobulin fusion protein, anti-CD40 monoclonal antibody, and anti-inducible costimulator monoclonal antibody. Migration of GFP-expressing host SCs into wild-type allografts was assessed in vivo every 3 weeks until 15 weeks postoperatively, and explanted allografts were evaluated for immunohistochemical staining patterns to differentiate graft from host SCs. Immunosuppression with tacrolimus exhibited a plateau of SC migration, characterized by significant early migration (< 3 weeks) followed by a constant level of host SCs in the graft (15 weeks). At the endpoint, graft fluorescence was decreased relative to surrounding host nerve, and donor SCs persisted within the graft. CSB-treated mice displayed gradually increasing migration of host SCs into the graft, without the plateau noted in tacrolimus-treated mice, and also maintained a population of donor SCs at the 15-week endpoint. SC migration patterns are affected by immunosuppressant choice, particularly in the immediate postoperative period, and the use of a single treatment of CSB may allow for gradual population of nerve allografts with host SCs. PMID:20633557

Factors Affecting Tocopherol Concentrations in Soybean Seeds.

Science.gov (United States)

Carrera, Constanza S; Seguin, Philippe

2016-12-21

Soybean seeds contain several health-beneficial compounds, including tocopherols, which are used by the nutraceutical and functional food industries. Soybean tocopherol concentrations are, however, highly variable. Large differences observed in tocopherol concentrations among soybean genotypes together with the relatively simple biosynthetic pathway involving few genes support the feasibility of selecting for high-tocopherol soybean. Tocopherol concentrations are also highly influenced by environmental factors and field management. Temperature during seed filling and soil moisture appear to be the main factors affecting tocopherol concentrations; other factors such as soil fertility and solar radiation also affect concentrations and composition. Field management decisions including seeding date, row spacing, irrigation, and fertilization also affect tocopherols. Knowledge of factors affecting soybean tocopherols is essential to develop management strategies that will lead to the production of seeds with consistent target concentrations that will meet the needs of the nutraceutical and functional food industries.

Factors Affecting Wound Healing

OpenAIRE

Guo, S.; DiPietro, L.A.

2010-01-01

Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutane...

Web-based Factors Affecting Online Purchasing Behaviour

Science.gov (United States)

Ariff, Mohd Shoki Md; Sze Yan, Ng; Zakuan, Norhayati; Zaidi Bahari, Ahamad; Jusoh, Ahmad

2013-06-01

The growing use of internet and online purchasing among young consumers in Malaysia provides a huge prospect in e-commerce market, specifically for B2C segment. In this market, if E-marketers know the web-based factors affecting online buyers' behaviour, and the effect of these factors on behaviour of online consumers, then they can develop their marketing strategies to convert potential customers into active one, while retaining existing online customers. Review of previous studies related to the online purchasing behaviour in B2C market has point out that the conceptualization and empirical validation of the online purchasing behaviour of Information and Communication Technology (ICT) literate users, or ICT professional, in Malaysia has not been clearly addressed. This paper focuses on (i) web-based factors which online buyers (ICT professional) keep in mind while shopping online; and (ii) the effect of web-based factors on online purchasing behaviour. Based on the extensive literature review, a conceptual framework of 24 items of five factors was constructed to determine web-based factors affecting online purchasing behaviour of ICT professional. Analysis of data was performed based on the 310 questionnaires, which were collected using a stratified random sampling method, from ICT undergraduate students in a public university in Malaysia. The Exploratory factor analysis performed showed that five factors affecting online purchase behaviour are Information Quality, Fulfilment/Reliability/Customer Service, Website Design, Quick and Details, and Privacy/Security. The result of Multiple Regression Analysis indicated that Information Quality, Quick and Details, and Privacy/Security affect positively online purchase behaviour. The results provide a usable model for measuring web-based factors affecting buyers' online purchase behaviour in B2C market, as well as for online shopping companies to focus on the factors that will increase customers' online purchase.

Web-based Factors Affecting Online Purchasing Behaviour

International Nuclear Information System (INIS)

Ariff, Mohd Shoki Md; Yan, Ng Sze; Zakuan, Norhayati; Bahari, Ahamad Zaidi; Jusoh, Ahmad

2013-01-01

The growing use of internet and online purchasing among young consumers in Malaysia provides a huge prospect in e-commerce market, specifically for B2C segment. In this market, if E-marketers know the web-based factors affecting online buyers' behaviour, and the effect of these factors on behaviour of online consumers, then they can develop their marketing strategies to convert potential customers into active one, while retaining existing online customers. Review of previous studies related to the online purchasing behaviour in B2C market has point out that the conceptualization and empirical validation of the online purchasing behaviour of Information and Communication Technology (ICT) literate users, or ICT professional, in Malaysia has not been clearly addressed. This paper focuses on (i) web-based factors which online buyers (ICT professional) keep in mind while shopping online; and (ii) the effect of web-based factors on online purchasing behaviour. Based on the extensive literature review, a conceptual framework of 24 items of five factors was constructed to determine web-based factors affecting online purchasing behaviour of ICT professional. Analysis of data was performed based on the 310 questionnaires, which were collected using a stratified random sampling method, from ICT undergraduate students in a public university in Malaysia. The Exploratory factor analysis performed showed that five factors affecting online purchase behaviour are Information Quality, Fulfilment/Reliability/Customer Service, Website Design, Quick and Details, and Privacy/Security. The result of Multiple Regression Analysis indicated that Information Quality, Quick and Details, and Privacy/Security affect positively online purchase behaviour. The results provide a usable model for measuring web-based factors affecting buyers' online purchase behaviour in B2C market, as well as for online shopping companies to focus on the factors that will increase customers' online purchase.

Determining the Factors Affecting Labor Productivity of Nurses

Directory of Open Access Journals (Sweden)

Yurdanur Dikmen

2016-12-01

Results: It was found that the 45.5% of nurses participated in the study were in the 23-53 age group, 79.5% were women, 76.9% married, 41.1% associate degree graduates. 42.3% of nurses' durations of professional experience were 0-5 years, 22.4% of nurses were clinical chief, 69.2% were working as shifts. Participants believe that the factors affecting the labor productivity were respectively organizational factors, ergonomic factors and personal factors. When organizational factors was examined; nurses stated that the lack of working personnel in the section, the low wages and unequal wages for the same work, the long working hours and the system which based on personal relations instead of merit were affecting productivity. The factors affecting labor productivity of nurses were not different according to age, gender, education level and marital status (p>0.05, but different according to mode of operation and years of experience (p<0.05. Conclusion: According to this study, it was found that there are many factors that affect the efficiency of the nurses. The most important factors affecting nurses' efficiency were determined as wage and working conditions. [J Contemp Med 2016; 6(4.000: 334-342

Lesion-induced increase in survival and migration of human neural progenitor cells releasing GDNF

Science.gov (United States)

Behrstock, Soshana; Ebert, Allison D.; Klein, Sandra; Schmitt, Melanie; Moore, Jeannette M.; Svendsen, Clive N.

2009-01-01

The use of human neural progenitor cells (hNPC) has been proposed to provide neuronal replacement or astrocytes delivering growth factors for brain disorders such as Parkinson’s and Huntington’s disease. Success in such studies likely requires migration from the site of transplantation and integration into host tissue in the face of ongoing damage. In the current study, hNPC modified to release glial cell line derived neurotrophic factor (hNPCGDNF) were transplanted into either intact or lesioned animals. GDNF release itself had no effect on the survival, migration or differentiation of the cells. The most robust migration and survival was found using a direct lesion of striatum (Huntington’s model) with indirect lesions of the dopamine system (Parkinson’s model) or intact animals showing successively less migration and survival. No lesion affected differentiation patterns. We conclude that the type of brain injury dictates migration and integration of hNPC which has important consequences when considering transplantation of these cells as a therapy for neurodegenerative diseases. PMID:19044202

Examining the Impact of Latino Nativity, Migration, and Acculturation Factors on Colonoscopy Screening.

Science.gov (United States)

Costas-Muñiz, Rosario; Jandorf, Lina; Philip, Errol; Cohen, Noah; Villagra, Cristina; Sriphanlop, Pathu; Schofield, Elizabeth; DuHamel, Katherine

2016-10-01

Latinos are a diverse population comprised of multiple countries of origin with varying cultural profiles. This study examines differences in colonoscopy completion across place of birth and migration-related factors in a sample of predominantly Dominican and Puerto Rican Latinos living in New York City after receiving a recommendation for colonoscopy screening and navigation services. The sample included 702 Latinos recruited for two cancer screening projects targeting Latinos eligible for colonoscopy who seek healthcare in New York City. Participants completed a survey that included sociodemographic, health-related questions, psychosocial assessments and cancer screening practices, in Spanish or English. Migration, acculturation, and language factors were found to predict colonoscopy completion. The results indicated that Latinos born in the Dominican Republic and Central America were more likely to complete a screening colonoscopy than their counterparts born in the US. Further, those who emigrated at an older age, who have resided in the US for less than 20 years, preferred Spanish and those with lower US acculturation levels were also more likely to complete a screening colonoscopy. The findings suggest that Latinos who are less acculturated to the US are more likely to complete a screening colonoscopy after receiving a physician recommendation for colonoscopy screening. The results provide important information that can inform clinical practice and public health interventions. Continued attention to cultural and migration influences are important areas for cancer screening intervention development.

Male out-migration: a factor for the spread of HIV infection among married men and women in rural India.

Directory of Open Access Journals (Sweden)

Niranjan Saggurti

Full Text Available INTRODUCTION: Thus far, the reasons for increasing HIV prevalence in northern and eastern Indian states are unknown. We investigated the role of male out-migration in the spread of human immunodeficiency virus (HIV infection through a case-control study in rural India. METHODS: Currently married men and women were recruited from HIV testing and treatment centers across seven selected districts with high rates of male out-migration in eastern and northern India in 2010 using a case-control study design. Case subjects (men: 595, women: 609 were people who tested HIV seropositive and control subjects (men: 611, women: 600 were those tested HIV seronegative. For each gender, we obtained adjusted odds ratios (AORs and population attributable risks (PARs for migration, and behavioral factors. RESULTS: For men, the prevalence of HIV was significantly higher among those with a migration history (AOR, 4.4; for women, the prevalence of HIV was higher among those with migrant husbands (AOR, 2·3. For both genders, the returned male migration (men: AOR, 3·7; women: AOR, 28 was significantly associated with higher prevalence of HIV infection. The PAR associated with male migration was higher for men (54.5%-68.6% than for women (32·7%-56·9% across the study areas. DISCUSSION: Male out-migration is the most important risk factor influencing the spread of HIV infection in rural areas with high out-migration rates, thereby emphasizing the need for interventions, particularly, for returned migrants and spouses of those migrants.

Improved survival of mesenchymal stem cells by macrophage migration inhibitory factor

OpenAIRE

Xia, Wenzheng; Xie, Congying; Jiang, Miaomiao; Hou, Meng

2015-01-01

Macrophage migration inhibitory factor (MIF) is a critical inflammatory cytokine that was recently associated with progenitor cell survival and potently inhibits apoptosis. We examined the protective effect of MIF on hypoxia/serum deprivation (SD)-induced apoptosis of mesenchymal stem cells (MSCs), as well as the possible mechanisms. MSCs were obtained from rat bone marrow and cultured in vitro. Apoptosis was induced by culturing MSCs under hypoxia/SD conditions for up to 24?h and assessed by...

Hydrogeochemical processes affecting the migration of radionuclides in a fluvial sand aquifer at the Chalk River Nuclear Laboratories

International Nuclear Information System (INIS)

Jackson, R.E.; Inch, K.J.

1980-01-01

In the mid-1950's two experimental disposals of liquid radioactive waste containing about 700 curries of strontium-90 and cesium-137 were made into pits in sandy ground at one of the disposal areas at Chalk River Nuclear Laboratories. Since then, the wastes have migrated into two nearby aquifers and have chromatographically separated into strontium-90 and cesium-137 plumes moving at velocities less than that of the transporting groundwater. Analysis of radioactively contaminated aquifer sediments showed that most of the strontium-90 is exchangeably adsorbed, primarily to feldspars and layer silicates (mainly biotite); the rest is either specifically adsorbed to iron (III) and perhaps manganese (IV) oxhydroxides or fixed to unknown sinks. Less than one half of adsorbed cesium-137 is exchangeable with 0.5 m calcium chloride; the high levels of cesium-137 adsorption and fixation are probably due to its reaction with micaceous minerals. Complexation of strontium-90 and cesium-137 does not appear to be an important factor affecting their transport or adsorption. In studies of groundwater quality or pollution, dissolved oxygen and sulfide should be measured in addition to the redox potential since it allows independent assessment of the redox levels. The latter were found to affect the mobility of multivalent transition metals and nonmetals. (DN)

Migration aspirations and migration cultures : A case study of Ukrainian migration towards the European Union

NARCIS (Netherlands)

Van Mol, C.; Snel, Erik; Hemmerechts, Kenneth; Timmerman, Christiane

2018-01-01

An abundant body of research focused on macrolevel, mesolevel, and microlevel factors explaining why individuals move across international borders. In this paper, we aim to complement the existing literature by exploring how, within a single country, mesolevel factors differently impact migration

Factors in the drop in the migration of Spanish-trained nurses: 1999-2007.

Science.gov (United States)

Galbany-Estragués, Paola; Nelson, Sioban

2018-05-01

To reveal correlates of the decrease of Spanish nurse migration (1999-2007). Nursing outmigration is a concern for countries. Nurse migration from Spain began in the 1990s. From 1999 to 2007, the yearly number of migrations dropped significantly. We ask what social, economic and policy factors could be related to this drop. We used publicly available statistics to confirm hypothesis (1) The drop in nursing migration coincided with a drop in nursing unemployment. Then we hypothesized that this coincided with (1a) a decrease in the number of graduates, (1b) an increase in the number of hospitals and/or beds functioning, and/or (1c) an increase in the ratio of part-time contracts. Our analysis confirms hypotheses (1) and (1c) and disconfirms (1a) and (1b). The greater availability of part-time contracts seems to have encouraged nurses to remain in Spain. The strategy to reduce nursing unemployment with more part-time contracts, while temporarily successful in Spain, brings with it major challenges for patient care and the working life of nurses. We suggest that nurse leaders and health policymakers consider proactive policies to adjust the balance between supply and demand without decreasing the quality of available positions. © 2017 The Authors. Journal of Nursing Management Published by John Wiley & Sons Ltd.

Wind effects on the migration routes of trans-Saharan soaring raptors: geographical, seasonal, and interspecific variation

Science.gov (United States)

Vidal-Mateo, Javier; Mellone, Ugo; López-López, Pascual; La Puente, Javier De; García-Ripollés, Clara; Bermejo, Ana; Urios, Vicente

2016-01-01

Abstract Wind is among the most important environmental factors shaping birds’ migration patterns. Birds must deal with the displacement caused by crosswinds and their behavior can vary according to different factors such as flight mode, migratory season, experience, and distance to goal areas. Here we analyze the relationship between wind and migratory movements of three raptor species which migrate by soaring–gliding flight: Egyptian vulture Neophron percnopterus, booted eagle Aquila pennata, and short-toed snake eagle Circaetus gallicus. We analyzed daily migratory segments (i.e., the path joining consecutive roosting locations) using data recorded by GPS satellite telemetry. Daily movements of Egyptian vultures and booted eagles were significantly affected by tailwinds during both autumn and spring migrations. In contrast, daily movements of short-toed eagles were only significantly affected by tailwinds during autumn migration. The effect of crosswinds was significant in all cases. Interestingly, Egyptian vultures and booted eagles showed latitudinal differences in their behavior: both species compensated more frequently at the onset of autumn migration and, at the end of the season when reaching their wintering areas, the proportion of drift segments was higher. In contrast, there was a higher drift at the onset of spring migration and a higher compensation at the end. Our results highlight the effect of wind patterns on the migratory routes of soaring raptors, with different outcomes in relation to species, season, and latitude, ultimately shaping the loop migration patterns that current tracking techniques are showing to be widespread in many long distance migrants. PMID:29491895

Factors affecting endoglucanase production by Trichoderma reesei ...

African Journals Online (AJOL)

Jane

2011-08-22

Aug 22, 2011 ... from the ANOVA analysis have a significant value of Pmodel>F= 0.0008 and R2 .... there are various environmental and nutritional factors ... reported to affect cellulase production from wheat straw ... many factors affecting simultaneously the fermentation ..... and control its stability (Kalra and Sandhu, 1986).

Effects of Migration on Women Mental Health

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Ayla Tuzcu

2015-03-01

Full Text Available People leave their habitats and go to different regions of the world due to various reasons, which is defined as migration. One of the most important changes that have been experienced in migration in the last half century is the increase in women's migration. Women are among the risk groups that are affected by the process of migration at most. A particular attention is attracted to the special requirements of women among groups that are obliged to migrate due to the crisis in their countries. Different lifestyles in the migrated social environment, difficult economic and working conditions, language barrier and relevant adaptation problems all negatively affect the mental health of these women. In order to protect and develop the mental health of migrant women from different cultural groups, it is important to approach these groups as primary risk groups and start multi-directional interventions aimed at their areas required. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2015; 7(1: 56-67

ERK-dependent and -independent pathways trigger human neural progenitor cell migration

International Nuclear Information System (INIS)

Moors, Michaela; Cline, Jason E.; Abel, Josef; Fritsche, Ellen

2007-01-01

Besides differentiation and apoptosis, cell migration is a basic process in brain development in which neural cells migrate several centimeters within the developing brain before reaching their proper positions and forming the right connections. For identifying signaling events that control neural migration and are therefore potential targets of chemicals to disturb normal brain development, we developed a human neurosphere-based migration assay based on normal human neural progenitor (NHNP) cells, in which the distance is measured that cells wander over time. Applying this assay, we investigated the role of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) in the regulation of NHNP cell migration. Exposure to model substances like ethanol or phorbol 12-myristate 13-acetate (PMA) revealed a correlation between ERK1/2 activation and cell migration. The participation of phospho-(P-) ERK1/2 was confirmed by exposure of the cells to the MEK inhibitor PD98059, which directly prohibits ERK1/2 phosphorylation and inhibited cell migration. We identified protein kinase C (PKC) and epidermal growth factor receptor (EGFR) as upstream signaling kinases governing ERK1/2 activation, thereby controlling NHNP cell migration. Additionally, treatments with src kinase inhibitors led to a diminished cell migration without affecting ERK1/2 phosphorylation. Based on these results, we postulate that migration of NHNP cells is controlled via ERK1/2-dependent and -independent pathways

Contextual investigation of factors affecting sludge accumulation ...

African Journals Online (AJOL)

Pit latrines in slums areas of Uganda fill up faster than might be expected from some estimates owing to inappropriate use and failure to consider critical factors affecting sludge accumulation rates at the planning, design and construction stages. This study sought to investigate factors affecting filling rates of lined pit latrines ...

Factors Affecting Wound Healing

Science.gov (United States)

Guo, S.; DiPietro, L.A.

2010-01-01

Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds. PMID:20139336

Transcription Factor SOX5 Promotes the Migration and Invasion of Fibroblast-Like Synoviocytes in Part by Regulating MMP-9 Expression in Collagen-Induced Arthritis

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Yumeng Shi

2018-04-01

Full Text Available ObjectivesFibroblast-like synoviocytes (FLS exhibit a unique aggressive phenotype in rheumatoid arthritis (RA. Increased FLS migration and subsequent invasion of the extracellular matrix are essential to joint destruction in RA. Our previous research reported that transcription factor SOX5 was highly expressed in RA-FLS. Here, the effects of SOX5 in RA-FLS migration and invasion will be investigated.MethodsThe migration and invasion of RA-FLS were evaluated using a transwell chamber assay. The expression of several potential SOX5-targeted genes, including matrix metalloproteinases (MMP-1, 2, 3 and 9, chemokines (CCL4, CCL2, CCR5 and CCR2, and pro-inflammatory cytokines (TNF-α and IL-6, were examined in RA-FLS using SOX5 gain- and loss-of-function study. The molecular mechanisms of SOX5-mediated MMP-9 expressions were assayed by luciferase reporter gene and chromatin immunoprecipitation (ChIP studies. The in vivo effect of SOX5 on FLS migration and invasion was examined using collagen-induced arthritis (CIA in DBA/1J mice.ResultsKnockdown SOX5 decreased lamellipodium formation, migration, and invasion of RA-FLS. The expression of MMP-9 was the only gene tested to be concomitantly affected by silencing or overexpressing SOX5. ChIP assay revealed that SOX5 was bound to the MMP-9 promoter in RA-FLS. The overexpression of SOX5 markedly enhanced the MMP-9 promoter activity, and specific deletion of a putative SOX5-binding site in MMP-9 promoter diminished this promoter-driven transcription in FLS. Locally knocked down SOX5 inhibited MMP-9 expression in the joint tissue and reduced pannus migration and invasion into the cartilage in CIA mice.ConclusionSOX5 plays a novel role in mediating migration and invasion of FLS in part by regulating MMP-9 expression in RA.

Transcription Factor SOX5 Promotes the Migration and Invasion of Fibroblast-Like Synoviocytes in Part by Regulating MMP-9 Expression in Collagen-Induced Arthritis.

Science.gov (United States)

Shi, Yumeng; Wu, Qin; Xuan, Wenhua; Feng, Xiaoke; Wang, Fang; Tsao, Betty P; Zhang, Miaojia; Tan, Wenfeng

2018-01-01

Fibroblast-like synoviocytes (FLS) exhibit a unique aggressive phenotype in rheumatoid arthritis (RA). Increased FLS migration and subsequent invasion of the extracellular matrix are essential to joint destruction in RA. Our previous research reported that transcription factor SOX5 was highly expressed in RA-FLS. Here, the effects of SOX5 in RA-FLS migration and invasion will be investigated. The migration and invasion of RA-FLS were evaluated using a transwell chamber assay. The expression of several potential SOX5-targeted genes, including matrix metalloproteinases (MMP-1, 2, 3 and 9), chemokines (CCL4, CCL2, CCR5 and CCR2), and pro-inflammatory cytokines (TNF-α and IL-6), were examined in RA-FLS using SOX5 gain- and loss-of-function study. The molecular mechanisms of SOX5-mediated MMP-9 expressions were assayed by luciferase reporter gene and chromatin immunoprecipitation (ChIP) studies. The in vivo effect of SOX5 on FLS migration and invasion was examined using collagen-induced arthritis (CIA) in DBA/1J mice. Knockdown SOX5 decreased lamellipodium formation, migration, and invasion of RA-FLS. The expression of MMP-9 was the only gene tested to be concomitantly affected by silencing or overexpressing SOX5. ChIP assay revealed that SOX5 was bound to the MMP-9 promoter in RA-FLS. The overexpression of SOX5 markedly enhanced the MMP-9 promoter activity, and specific deletion of a putative SOX5-binding site in MMP-9 promoter diminished this promoter-driven transcription in FLS. Locally knocked down SOX5 inhibited MMP-9 expression in the joint tissue and reduced pannus migration and invasion into the cartilage in CIA mice. SOX5 plays a novel role in mediating migration and invasion of FLS in part by regulating MMP-9 expression in RA.

Recovery Migration to the City of New Orleans after Hurricane Katrina: A Migration Systems Approach.

Science.gov (United States)

Fussell, Elizabeth; Curtis, Katherine J; Dewaard, Jack

2014-03-01

Hurricane Katrina's effect on the population of the City of New Orleans provides a model of how severe weather events, which are likely to increase in frequency and strength as the climate warms, might affect other large coastal cities. Our research focuses on changes in the migration system - defined as the system of ties between Orleans Parish and all other U.S. counties - between the pre-disaster (1999-2004) and recovery (2007-2009) periods. Using Internal Revenue Service county-to-county migration flow data, we find that in the recovery period Orleans Parish increased the number of migration ties with and received larger migration flows from nearby counties in the Gulf of Mexico coastal region, thereby spatially concentrating and intensifying the in-migration dimension of this predominantly urban system, while the out-migration dimension contracted and had smaller flows. We interpret these changes as the migration system relying on its strongest ties to nearby and less damaged counties to generate recovery in-migration.

Migration Theories and Mental Health in Toni Morrison's Jazz

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Leila Tafreshi Motalgh

2015-01-01

Full Text Available This article aims to elaborate the relationship between migration and mental health problems that are evident in migrant women in Toni Morrison's Jazz (1992. To this end, pre-migration, migration and post-migration stress factors are identified in the novel based on Danish Bhugra's theory of migration. It seems that pre-migration stress factors and traumas are associated with the push theory of migration, while post-migration stresses are associated with the pull theory of migration. Despite post-migration stresses, the main female characters who encounter pre-migration stress factors and traumas are more likely to develop mental health problems like Post-traumatic Stress Disorder (PTSD. Although there is extensive literary criticism of Jazz (1992, no theoretical criticism exists that simultaneously covers migration theories and the mental health problems evident in Toni Morrison's female characters. It is worth highlighting that gender is a variable that correlates positively with migration and mental health. This article attempts to fill a gap in literary criticism and contribute to the body of research on mental health problems associated with gender and migration. Keywords: Push-Pull Theory, Great Migration, Black Studies, Gender, Trauma, PTSD

Rho A Regulates Epidermal Growth Factor-Induced Human Osteosarcoma MG63 Cell Migration

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Jinyang Wang

2018-05-01

Full Text Available Osteosarcoma, the most common primary bone tumor, occurs most frequently in children and adolescents and has a 5-year survival rate, which is unsatisfactory. As epidermal growth factor receptor (EGFR positively correlates with TNM (tumor-node-metastasis stage in osteosarcoma, EGFR may play an important role in its progression. The purpose of this study was to explore potential mechanisms underlying this correlation. We found that EGF promotes MG63 cell migration and invasion as well as stress fiber formation via Rho A activation and that these effects can be reversed by inhibiting Rho A expression. In addition, molecules downstream of Rho A, including ROCK1, LIMK2, and Cofilin, are activated by EGF in MG63 cells, leading to actin stress fiber formation and cell migration. Moreover, inhibition of ROCK1, LIMK2, or Cofilin in MG63 cells using known inhibitors or short hairpin RNA (shRNA prevents actin stress fiber formation and cell migration. Thus, we conclude that Rho A/ROCK1/LIMK2/Cofilin signaling mediates actin microfilament formation in MG63 cells upon EGFR activation. This novel pathway provides a promising target for preventing osteosarcoma progression and for treating this cancer.

Inflammation and cancer: macrophage migration inhibitory factor (MIF)--the potential missing link.

LENUS (Irish Health Repository)

Conroy, H

2010-11-01

Macrophage migration inhibitory factor (MIF) was the original cytokine, described almost 50 years ago and has since been revealed to be an important player in pro-inflammatory diseases. Recent work using MIF mouse models has revealed new roles for MIF. In this review, we present an increasing body of evidence implicating the key pro-inflammatory cytokine MIF in specific biological activities related directly to cancer growth or contributing towards a microenvironment favouring cancer progression.

Quantitative Analysis of the Factors Influencing Soil Heavy Metal Lateral Migration in Rainfalls Based on Geographical Detector Software: A Case Study in Huanjiang County, China

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Pengwei Qiao

2017-07-01

Full Text Available Quantitative analysis of the factors influencing heavy metal migration could be useful for controlling heavy metal migration. In this paper, a geographical detector was used to calculate the contributions of and interactions among factors in Huanjiang County, South China, covering an area of 273 km2. In this paper, nine factors were analyzed. The results showed that, among these factors, soil type was the main factor influencing the migration of As, Pb and Cd; the other eight factors did not have big differences and were lower than soil type. In addition, there were obvious synergistic effects between the soil type and concentration of water-soluble heavy metals (CWS and the concentration of water-insoluble heavy metals (CWI and NDVI. Therefore, these factors of the study area were especially focused on. Furthermore, the results of the key factor identification and the high-risk region identification in the nine factors were reliable, based on the geographical detector software. Therefore, the geographical detector software could be used as an effective tool to quantitatively analyze the contribution of the factors, and identify the high-risk regions for the factors influencing soil heavy metal lateral migration in rainfalls.

Integrating meteorology into research on migration

NARCIS (Netherlands)

Shamoun-Baranes, J.; Bouten, W.; van Loon, E.E.

2010-01-01

Atmospheric dynamics strongly influence the migration of flying organisms. They affect, among others, the onset, duration and cost of migration, migratory routes, stop-over decisions, and flight speeds en-route. Animals move through a heterogeneous environment and have to react to atmospheric

Identification of factors affecting individual industries

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Maryam Sadat Mirzadeh

2017-10-01

Full Text Available High knowledge and technology are rapidly becoming a competitive advantage in today’s world. Individual industries are considered one of the key sectors in the country’s industry. Ranking the factors that affect these industries makes us more familiar with their effectiveness and helps us take actions to improve such factors in knowledge-based companies. Consequently, based on previous research studies on Individual Industries, field observations, and a questionnaire prepared by the researchers, the current study explores and classifies the factors affecting the establishment of these industries. Regarding its purpose, this is an applied research, and regarding data collection, it is a descriptive survey. Using purposive sampling, 60 questionnaires were collected and effective factors were classified applying the SPSS software and the TOPSIS technique. This study suggests that content factors are ranked first place, while contextual and structural factors are ranked second and third, respectively. Therefore, executives and managers in single industries are recommended to strengthen joint enterprise norms and dominant values and beliefs in knowledge-based companies in order to help the growth and development of single industries.

Variation of 137Cs migration parameters in soils

International Nuclear Information System (INIS)

Silant'ev, A.N.; Shkuratova, I.G.

1988-01-01

Quasidiffusion model accounting the oriented migration is used to describe the observed profiles of 137 Cs distribution in soil. A way of model use in case of real soil, the quasidiffusion migration factor being varied, is suggested. It is shown that in the upper thin soil layer the quasidiffusion migration factor and oriented migration rate values are constant. With further increase of depth the quasidiffusion coefficient grows, the oriented migration rate is unchanged. On the basis of location data characteristic values of migration parameters for different soils of the USSR European territory depending on the soil texture, vegetative cover and moistening are determined

Does Choice of Head Size and Neck Geometry Affect Stem Migration in Modular Large-Diameter Metal-on-Metal Total Hip Arthroplasty? A Preliminary Analysis.

Science.gov (United States)

Georgiou, Cs; Evangelou, Kg; Theodorou, Eg; Provatidis, Cg; Megas, Pd

2012-01-01

Due to their theoretical advantages, hip systems combining modular necks and large diameter femoral heads have gradually gained popularity. However, among others, concerns regarding changes in the load transfer patterns were raised. Recent stress analyses have indeed shown that the use of modular necks and big femoral heads causes significant changes in the strain distribution along the femur. Our original hypothesis was that these changes may affect early distal migration of a modular stem. We examined the effect of head diameter and neck geometry on migration at two years of follow-up in a case series of 116 patients (125 hips), who have undergone primary Metal-on-Metal total hip arthroplasty with the modular grit-blasted Profemur®E stem combined with large-diameter heads (>36 mm). We found that choice of neck geometry and head diameter has no effect on stem migration. A multivariate regression analysis including the potential confounding variables of the body mass index, bone quality, canal fill and stem positioning revealed only a negative correlation between subsidence and canal fill in midstem area. Statistical analysis, despite its limitations, did not confirm our hypothesis that choice of neck geometry and/or head diameter affects early distal migration of a modular stem. However, the importance of correct stem sizing was revealed.

Factors affecting farm diversification in rice-wheat

International Nuclear Information System (INIS)

Ashfaq, M.; Hassan, S.; Naseer, M.Z.; Baig, I.A.; Asma, J.

2008-01-01

The risk in agriculture sector is due to various factors like weather and market conditions, particularly the demand of the commodities. This uncertainty can result in variable returns (farm income) to the decisions that farmers make in a particular season. Diversification is a frequently used risk management strategy that involves participation in more than one activity. It has the added advantage of mitigating price risk as well as fluctuations in outputs. The main purpose of this paper was to determine the factors affecting crop diversification. For determining the effect of different factors on diversification a multiple regression model was used. The values of Entropy index computed for measuring horizontal diversification were taken as dependent variable and different factors affecting diversification were taken as independent variables. The results showed that the main factors affecting diversification were size of land holding, age of respondent, education level of respondent, farming experience of respondent, off farm income of respondent, distance of farm from main road, distance of farm from main market and farm machinery. (author)

Macrophage migration inhibitory factor (MIF) modulates trophic signaling through interaction with serine protease HTRA1

DEFF Research Database (Denmark)

Fex Svenningsen, Åsa; Loering, Svenja; Sørensen, Anna Lahn

2017-01-01

Macrophage migration inhibitory factor (MIF), a small conserved protein, is abundant in the immune- and central nervous system (CNS). MIF has several receptors and binding partners that can modulate its action on a cel-lular level. It is upregulated in neurodegenerative diseases and cancer although...

Polarization and Segregation through Conformity Pressure and Voluntary Migration: Simulation Analysis of Co-Evolutionary Dynamics

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Dai Zusai

2017-11-01

Full Text Available While conformity pressures people to assimilate in a community, an individual occasionally migrates among communities when the individual feels discomfort. These two factors cause segregation and cultural diversity within communities in the society. By embedding a migration dynamic into Kuran and Sandholm’s model (2008 of preference evolution, we build an agent-based model to see how the variance of preferences in the entire society quantitatively changes over time. We find from the Monte-Carlo simulations that, while preferences assimilate within a community, self-selected migrations enlarge the diversity of preferences over communities in the society. We further study how the arrival rate of migration opportunities and the degree of conformity pressures affect the variance of preferences.

Src Induces Podoplanin Expression to Promote Cell Migration*

Science.gov (United States)

Shen, Yongquan; Chen, Chen-Shan; Ichikawa, Hitoshi; Goldberg, Gary S.

2010-01-01

Nontransformed cells can force tumor cells to assume a normal morphology and phenotype by the process of contact normalization. Transformed cells must escape this process to become invasive and malignant. However, mechanisms underlying contact normalization have not been elucidated. Here, we have identified genes that are affected by contact normalization of Src-transformed cells. Tumor cells must migrate to become invasive and malignant. Src must phosphorylate the adaptor protein Cas (Crk-associated substrate) to promote tumor cell motility. We report here that Src utilizes Cas to induce podoplanin (Pdpn) expression to promote tumor cell migration. Pdpn is a membrane-bound extracellular glycoprotein that associates with endogenous ligands to promote tumor cell migration leading to cancer invasion and metastasis. In fact, Pdpn expression accounted for a major part of the increased migration seen in Src-transformed cells. Moreover, nontransformed cells suppressed Pdpn expression in adjacent Src-transformed cells. Of >39,000 genes, Pdpn was one of only 23 genes found to be induced by transforming Src activity and suppressed by contact normalization of Src-transformed cells. In addition, we found 16 genes suppressed by Src and induced by contact normalization. These genes encode growth factor receptors, adaptor proteins, and products that have not yet been annotated and may play important roles in tumor cell growth and migration. PMID:20123990

ELEVATED CIRCULATING LEVELS OF MACROPHAGE MIGRATION INHIBITORY FACTOR IN POLYCYSTIC OVARY SYNDROME

OpenAIRE

González, Frank; Rote, Neal S.; Minium, Judi; Weaver, Amy L.; Kirwan, John P.

2010-01-01

Women with Polycystic Ovary Syndrome (PCOS) have chronic low level inflammation which can increase the risk of atherogenesis. We evaluated the status of circulating macrophage migration inhibitory factor (MIF), a proinflammatory cytokine involved in atherogenesis, in women with PCOS and weight-matched controls. Two-way analysis of variance models adjusted for age were fit to evaluate the effect of PCOS status (PCOS vs. controls) and weight-class (obese vs. lean) on MIF and other parameters. M...

Mechano-growth factor induces migration of rat mesenchymal stem cells by altering its mechanical properties and activating ERK pathway

Energy Technology Data Exchange (ETDEWEB)

Wu, Jiamin; Wu, Kewen; Lin, Feng; Luo, Qing; Yang, Li; Shi, Yisong [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China); Song, Guanbin, E-mail: song@cqu.edu.cn [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China); Sung, Kuo-Li Paul [Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044 (China); Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0412 (United States)

2013-11-08

Highlights: •MGF induced the migration of rat MSC in a concentration-dependent manner. •MGF enhanced the mechanical properties of rMSC in inducing its migration. •MGF activated the ERK 1/2 signaling pathway of rMSC in inducing its migration. •rMSC mechanics may synergy with ERK 1/2 pathway in MGF-induced rMSC migration. -- Abstract: Mechano-growth factor (MGF) generated by cells in response to mechanical stimulation has been identified as a mechano effector molecule, playing a key role in regulating mesenchymal stem cell (MSC) function, including proliferation and migration. However, the mechanism(s) underlying how MGF-induced MSC migration occurs is still unclear. In the present study, MGF motivated migration of rat MSCs (rMSCs) in a concentration-dependent manner and optimal concentration of MGF at 50 ng/mL (defined as MGF treatment in this paper) was demonstrated. Notably, enhancement of mechanical properties that is pertinent to cell migration, such as cell traction force and cell stiffness were found to respond to MGF treatment. Furthermore, MGF increased phosphorylation of extracellular signal-regulated kinase (ERK), ERK inhibitor (i.e., PD98059) suppressed ERK phosphorylation, and abolished MGF-induced rMSC migration were found, demonstrating that ERK is involved molecule for MGF-induced rMSC migration. These in vitro evidences of MGF-induced rMSC migration and its direct link to altering rMSC mechanics and activating the ERK pathway, uncover the underlying biomechanical and biological mechanisms of MGF-induced rMSC migration, which may help find MGF-based application of MSC in clinical therapeutics.

Brain Drain: Post Graduation Migration Intentions and the influencing factors among Medical Graduates from Lahore, Pakistan.

Science.gov (United States)

Imran, Nazish; Azeem, Zahra; Haider, Imran I; Amjad, Naeem; Bhatti, Muhammad R

2011-10-17

The increasing migration of health professionals to affluent countries is not a recent phenomenon and has been addressed in literature. However the various facets of physician migration from Pakistan, the third leading source of International medical graduates has not been rigorously evaluated. The objective of the current study was to survey final year students and recent medical graduates in Lahore, Pakistan about their intentions to train abroad, their post training plans as well as to identify the factors responsible for their motivation for international migration. A self administered structured questionnaire was developed to collect respondents' demographic and educational characteristics, intention to train abroad, their preferred destination & post training intentions of returning to Pakistan. Various influencing factors which impact on medical graduate's motivation to train abroad or stay in Pakistan were explored using a 10 point scale. SPSS software was used for data entry and analysis. Of the 400 eligible respondents, 275 responded (response rate 68.7%). One hundred and sixty six respondents (60.4%) intended to train abroad either for a specialty (54.9%) or a subspecialty (5.5%) The United States and United Kingdom were the most preferred destination. While 14.2% intended to return to Pakistan immediately after training, a significant percentage (10%) never intended to return to Pakistan or wished to stay abroad temporarily (37%). Professional excellence and establishing quickly in the competitive market were the most important goal to be achieved by the respondents for intention for postgraduate training abroad. The most common reasons cited for training abroad were the impact of residency training on future career (mean score 8.20 ± 2.3), financial conditions of doctors (mean score 7.97 ± 2.37) and job opportunities (mean score7.90 ± 2.34). An alarming percentage of medical graduates from Lahore, Pakistan intend to migrate for post graduate

Brain Drain: Post Graduation Migration Intentions and the influencing factors among Medical Graduates from Lahore, Pakistan

Directory of Open Access Journals (Sweden)

Imran Nazish

2011-10-01

Full Text Available Abstract Background The increasing migration of health professionals to affluent countries is not a recent phenomenon and has been addressed in literature. However the various facets of physician migration from Pakistan, the third leading source of International medical graduates has not been rigorously evaluated. The objective of the current study was to survey final year students and recent medical graduates in Lahore, Pakistan about their intentions to train abroad, their post training plans as well as to identify the factors responsible for their motivation for international migration. Method A self administered structured questionnaire was developed to collect respondents' demographic and educational characteristics, intention to train abroad, their preferred destination & post training intentions of returning to Pakistan. Various influencing factors which impact on medical graduate's motivation to train abroad or stay in Pakistan were explored using a 10 point scale. SPSS software was used for data entry and analysis. Results Of the 400 eligible respondents, 275 responded (response rate 68.7%. One hundred and sixty six respondents (60.4% intended to train abroad either for a specialty (54.9% or a subspecialty (5.5% The United States and United Kingdom were the most preferred destination. While 14.2% intended to return to Pakistan immediately after training, a significant percentage (10% never intended to return to Pakistan or wished to stay abroad temporarily (37%. Professional excellence and establishing quickly in the competitive market were the most important goal to be achieved by the respondents for intention for postgraduate training abroad. The most common reasons cited for training abroad were the impact of residency training on future career (mean score 8.20 ± 2.3, financial conditions of doctors (mean score 7.97 ± 2.37 and job opportunities (mean score7.90 ± 2.34. Conclusion An alarming percentage of medical graduates from

MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

DEFF Research Database (Denmark)

Tseng, Kuan-Yin; Anttila, Jenni E; Khodosevich, Konstantin

2018-01-01

die shortly after injury or are unable to arrive at the infarct boundary. In this study, we demonstrate for the first time that endogenous mesencephalic astrocyte-derived neurotrophic factor (MANF) protects NSCs against oxygen-glucose-deprivation-induced injury and has a crucial role in regulating NPC...... migration. In NSC cultures, MANF protein administration did not affect growth of cells but triggered neuronal and glial differentiation, followed by activation of STAT3. In SVZ explants, MANF overexpression facilitated cell migration and activated the STAT3 and ERK1/2 pathway. Using a rat model of cortical...... stroke, intracerebroventricular injections of MANF did not affect cell proliferation in the SVZ, but promoted migration of doublecortin (DCX)+ cells toward the corpus callosum and infarct boundary on day 14 post-stroke. Long-term infusion of MANF into the peri-infarct zone increased the recruitment...

Refugees migration as a factor of human resources redistribution in the world: problems of conflict economy’s development

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Ievdokymov V.V.

2017-06-01

Full Text Available Numerous humanitarian, socio-economic and environmental problems caused by the worldwide refugees’ migration lead to aggravation of the political debate on these issues. A geo-economic transformation in the world, which consists of multipolar geo-economic space formation, causing the need to managing migration movements of refugees between countries and regions around the world. This is associated with the importance of consideration of refugees’ migration as a factor of human resources redistribution in the world and the need to develop the regional migration policies for eliminating the negative effects of such migration. The research aimed to studying the current trends, preconditions and problems of refugees’ migration as a special category of migrants from countries developing in conflict and in post-conflict conditions. Found that there are military conflicts in all the countries that are leaders by refugees’ origin. In addition, the indicators of refugees’ pressure on socio-demographic, territorial and economic systems of host countries have been described, as well as analysis of the main refugees’ destination countries indicators has been carried out. This analysis has been done in interconnection with the surveyed countries rank in the Fragile States Index 2017.

Notch signaling mediates granulocyte-macrophage colony-stimulating factor priming-induced transendothelial migration of human eosinophils.

Science.gov (United States)

Liu, L Y; Wang, H; Xenakis, J J; Spencer, L A

2015-07-01

Priming with cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF) enhances eosinophil migration and exacerbates the excessive accumulation of eosinophils within the bronchial mucosa of asthmatics. However, mechanisms that drive GM-CSF priming are incompletely understood. Notch signaling is an evolutionarily conserved pathway that regulates cellular processes, including migration, by integrating exogenous and cell-intrinsic cues. This study investigates the hypothesis that the priming-induced enhanced migration of human eosinophils requires the Notch signaling pathway. Using pan Notch inhibitors and newly developed human antibodies that specifically neutralize Notch receptor 1 activation, we investigated a role for Notch signaling in GM-CSF-primed transmigration of human blood eosinophils in vitro and in the airway accumulation of mouse eosinophils in vivo. Notch receptor 1 was constitutively active in freshly isolated human blood eosinophils, and inhibition of Notch signaling or specific blockade of Notch receptor 1 activation during GM-CSF priming impaired priming-enhanced eosinophil transendothelial migration in vitro. Inclusion of Notch signaling inhibitors during priming was associated with diminished ERK phosphorylation, and ERK-MAPK activation was required for GM-CSF priming-induced transmigration. In vivo in mice, eosinophil accumulation within allergic airways was impaired following systemic treatment with Notch inhibitor, or adoptive transfer of eosinophils treated ex vivo with Notch inhibitor. These data identify Notch signaling as an intrinsic pathway central to GM-CSF priming-induced eosinophil tissue migration. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Meningeal defects alter the tangential migration of cortical interneurons in Foxc1hith/hith mice

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Zarbalis Konstantinos

2012-01-01

Full Text Available Abstract Background Tangential migration presents the primary mode of migration of cortical interneurons translocating into the cerebral cortex from subpallial domains. This migration takes place in multiple streams with the most superficial one located in the cortical marginal zone. While a number of forebrain-expressed molecules regulating this process have emerged, it remains unclear to what extent structures outside the brain, like the forebrain meninges, are involved. Results We studied a unique Foxc1 hypomorph mouse model (Foxc1hith/hith with meningeal defects and impaired tangential migration of cortical interneurons. We identified a territorial correlation between meningeal defects and disruption of interneuron migration along the adjacent marginal zone in these animals, suggesting that impaired meningeal integrity might be the primary cause for the observed migration defects. Moreover, we postulate that the meningeal factor regulating tangential migration that is affected in homozygote mutants is the chemokine Cxcl12. In addition, by using chromatin immunoprecipitation analysis, we provide evidence that the Cxcl12 gene is a direct transcriptional target of Foxc1 in the meninges. Further, we observe migration defects of a lesser degree in Cajal-Retzius cells migrating within the cortical marginal zone, indicating a less important role for Cxcl12 in their migration. Finally, the developmental migration defects observed in Foxc1hith/hith mutants do not lead to obvious differences in interneuron distribution in the adult if compared to control animals. Conclusions Our results suggest a critical role for the forebrain meninges to promote during development the tangential migration of cortical interneurons along the cortical marginal zone and Cxcl12 as the factor responsible for this property.

Age Learning Factors Affecting Pilot Education.

Science.gov (United States)

Torbert, Brison

This document, intended for pilot education and flight safety specialists, consists chiefly of a review of the literature on physiological factors that affect pilot education and an examination of environmental factors that should be scrutinized in order to improve the effectiveness of aviation learning facilities. The physiological factors…

Influences of body size and environmental factors on autumn downstream migration of bull trout in the Boise River, Idaho

Science.gov (United States)

Monnot, L.; Dunham, J.B.; Hoem, T.; Koetsier, P.

2008-01-01

Many fishes migrate extensively through stream networks, yet patterns are commonly described only in terms of the origin and destination of migration (e.g., between natal and feeding habitats). To better understand patterns of migration in bull trout,Salvelinus confluentus we studied the influences of body size (total length [TL]) and environmental factors (stream temperature and discharge) on migrations in the Boise River basin, Idaho. During the autumns of 2001-2003, we tracked the downstream migrations of 174 radio-tagged bull trout ranging in size from 21 to 73 cm TL. The results indicated that large bull trout (>30 cm) were more likely than small fish to migrate rapidly downstream after spawning in headwater streams in early autumn. Large bull trout also had a higher probability of arriving at the current terminus of migration in the system, Arrowrock Reservoir. The rate of migration by small bull trout was more variable and individuals were less likely to move into Arrowrock Reservoir. The rate of downstream migration by all fish was slower when stream discharge was greater. Temperature was not associated with the rate of migration. These findings indicate that fish size and environmentally related changes in behavior have important influences on patterns of migration. In a broader context, these results and other recent work suggest, at least in some cases, that commonly used classifications of migratory behavior may not accurately reflect the full range of behaviors and variability among individuals (or life stages) and environmental conditions. ?? Copyright by the American Fisheries Society 2008.

Perceived Factors Affecting Performance Of Extension Workers In ...

African Journals Online (AJOL)

The study focused on perceived factors affecting performance of extension workers in Imo State, Nigeria. Data for the study was collected from 83 Extension agents from the Imo State Agricultural Development Programme (ADP). Results of the study revealed that the organizational factors that affect performance are ...

Demographic situation and population migration problems

International Nuclear Information System (INIS)

1993-01-01

Problem of the Chernobyl accident effect on the population migration in controlled areas of the Ukraine, Belarus and in Russian Federation. Comparison of the data on migration for 1990 and for 1995 has shown considerable growth of the intensity of efflux of rural population at most Ukrainian areas affected due to the Chernobyl accident. Negative migration growth in urban settlements of these regions is marked. Decrease in rural resident migration is observed. Migrant current in Russia is twice increased. Main regions of North-West, Central, North-Caucasus ones in Russia and Donetsk-Dnieper river in the Ukraine. 6 tabs

International migration from non-endemic settings as a protective factor for HIV/STI risk among female sex workers in Vancouver, Canada.

Science.gov (United States)

Goldenberg, Shira M; Liu, Vivian; Nguyen, Paul; Chettiar, Jill; Shannon, Kate

2015-02-01

Given heterogeneous evidence regarding the impacts of migration on HIV/sexually transmitted infections (STIs) among female sex workers (FSWs), we explored factors associated with international migration among FSWs in Vancouver, Canada. We draw on baseline questionnaire and HIV/STI testing data from a community-based cohort, AESHA, from 2010-2012. Logistic regression identified correlates of international migration. Of 650 FSWs, 163 (25.1%) were international migrants, who primarily worked in formal indoor establishments. HIV/STI prevalence was lower among migrants than Canadian-born women (5.5 vs. 25.9%). In multivariate analysis, international migration was positively associated with completing high school, supporting dependents, and paying a third party, and negatively associated with HIV, injecting drugs and inconsistent condom use with clients. Although migrants experience lower workplace harms and HIV risk than Canadian-born women, they face concerning levels of violence, police harassment, and HIV/STIs. Research exploring structural and socio-cultural factors shaping risk mitigation and migrants' access to support remains needed.

ANALYSIS OF THE FACTORS AFFECTING THE AVERAGE

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Carmen BOGHEAN

2013-12-01

Full Text Available Productivity in agriculture most relevantly and concisely expresses the economic efficiency of using the factors of production. Labour productivity is affected by a considerable number of variables (including the relationship system and interdependence between factors, which differ in each economic sector and influence it, giving rise to a series of technical, economic and organizational idiosyncrasies. The purpose of this paper is to analyse the underlying factors of the average work productivity in agriculture, forestry and fishing. The analysis will take into account the data concerning the economically active population and the gross added value in agriculture, forestry and fishing in Romania during 2008-2011. The distribution of the average work productivity per factors affecting it is conducted by means of the u-substitution method.

Regime shifts in shallow lakes: the importance of seasonal fish migration

DEFF Research Database (Denmark)

Brönmark, Christer; Brodersen, Jakob; Chapman, Ben B.

2010-01-01

. Our earlier research shows that a large proportion of zooplanktivorous fish populations in shallow lakes undertake seasonal migrations where they leave the lake during winter and migrate back to the lake in spring. Based on our past research, we propose a number of scenarios of how feedback processes...... properties, including piscivore abundance and zooplankton productivity, affect the individual state of zooplanktivorous fish, such as growth rate or condition. Individual state, in turn, affects the relative proportion and timing of migrating zooplanktivorous fish. This change, in turn, may stabilize states...... between the individual and ecosystem levels may affect stability of alternative stable states in shallow lakes when mediated by fish migration. Migration effects on shallow lakes result from processes at different scales, from the individual to the ecosystem. Our earlier research has shown that ecosystem...

Environmental Factors Affecting Preschoolers' Motor Development

Science.gov (United States)

Venetsanou, Fotini; Kambas, Antonis

2010-01-01

The process of development occurs according to the pattern established by the genetic potential and also by the influence of environmental factors. The aim of the present study was to focus on the main environmental factors affecting motor development. The review of the literature revealed that family features, such as socioeconomic status,…

Multiple spring migration strategies in a population of Pacific Common Eiders

Science.gov (United States)

Petersen, M.R.

2009-01-01

Spring migration strategies vary within and among species. Examination of this variability extends our understanding of life histories and has implications for conservation. I used satellite transmitters to determine migration strategies and evaluate factors influencing the timing of spring migration of Pacific Common Eiders (Somateria mollissima v-nigrum) that nest along the western Beaufort Sea coast. Adult females were marked at nesting colonies in the summers of 2000, 2001, and 2003, and were followed throughout spring migration the following year. Each year approximately equal proportions of eiders used three distinct migration strategies varying in duration, staging locations (waters near the Chukotka Peninsula, Russia, and the Chukchi and Beaufort seas, Alaska), and arrival dates at the nesting areas. It is unlikely that differences in the timing of movements to stopover sites in the Chukchi and Beaufort seas were a result of responses to changes in weather, particularly wind direction. Ice distribution and melt/movement patterns vary substantially among staging areas and thus may affect risk of starvation and reproductive potential. Long-term (decadal) changes in climate may favor birds using one strategy during "warmer" and another during "colder" years. ?? 2009 by The Cooper Ornithological Society. All rights reserved.

Radionuclide migration studies in soil

International Nuclear Information System (INIS)

Marumo, J.T.

1989-01-01

In this work a brief description about retention and migration parameters of radionuclides in soil, including main methods to determine the distribution coefficient (K) are given. Some of several factors that can act on the migration are also mentioned. (author) [pt

Taiwan’s Security Calculus of Cross-­Strait Migration

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Ching Chang

2015-08-01

Full Text Available Migration across the Taiwan Strait is relatively insignificant by its scale but it is indeed indisputably politically sensitive. Given the long-term political separation and military rivalry across the Taiwan Strait in the past six decades while both sides of the Taiwan Strait nevertheless intensively engaged each other economically, commercially and culturally, a social trend of cross-Strait migration inevitably results. There are various interpretations on such a demographic development which has raised security concerns, which are in turn creating a biased judiciary arrangement on the migration activities. What are the factors behind the security calculus of cross-Strait migration? How can the security calculus justify its arguments and subsequently maintain unequal treatments with respect to cross-Strait immigrants? Are the rationales for maintaining a tight grip on cross-Strait migration in line with the political ideal proclaimed by the political factions in Taiwan still sensible? What is the potential for the trend of cross-Strait migration affecting the security calculus in the future? On the other hand, for the migration from Taiwan to Mainland China, how influential can it be on the security decision-making process of the Beijing leadership? Is there any impact possibly caused by cross-Strait migration – and is it essentially overstated? Or alternatively, is the overstated influence potentially caused by cross-Strait migration an intentionally staged political myth? What are the substantial impacts actually ever achieved by cross-Strait migration on the security dimension? What is the self-fulfilled conviction of cross-Strait migration? For all the inquiries noted above, the author of this paper would like to scrutinize the truth and separate it from numerous myths ever advocated by the different factions in Taiwan politics. A sound and neutral judgment to tell the exact influences likely enacted by cross-Strait migration would

Forced migration and mental health: prolonged internal displacement, return migration and resilience.

Science.gov (United States)

Siriwardhana, Chesmal; Stewart, Robert

2013-03-01

Forced internal displacement has been rising steadily, mainly due to conflict. Many internally displaced people (IDP) experience prolonged displacement. Global research evidence suggests that many of these IDP are at high risk for developing mental disorders, adding weight to the global burden of disease. However, individual and community resilience may act as protective factors. Return migration may be an option for some IDP populations, especially when conflicts end, although return migration may itself be associated with worse mental health. Limited evidence is available on effects of resettlement or return migration following prolonged forced internal displacement on mental health. Also, the role of resilience factors remains to be clarified following situations of prolonged displacement. The public health impact of internal displacement is not clearly understood. Epidemiological and interventional research in IDP mental health needs to look beyond medicalised models and encompass broader social and cultural aspects. The resilience factor should be integrated and explored more in mental health research among IDP and a clearly focused multidisciplinary approach is advocated.

Interspecific comparison of the performance of soaring migrants in relation to morphology, meteorological conditions and migration strategies.

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Ugo Mellone

Full Text Available BACKGROUND: Performance of migrating birds can be affected by a number of intrinsic and extrinsic factors like morphology, meteorological conditions and migration strategies. We compared travel speeds of four raptor species during their crossing of the Sahara desert. Focusing the analyses on this region allows us to compare different species under equivalent conditions in order to disentangle which factors affect migratory performance. METHODOLOGY/PRINCIPAL FINDING: We tracked raptors using GPS satellite transmitters from Sweden, Spain and Italy, and evaluated their migratory performance at both an hourly and a daily scale. Hourly data (flight speed and altitude for intervals of two hours were analyzed in relation to time of day, species and season, and daily data (distance between roosting sites in relation to species, season, day length and tailwind support. CONCLUSIONS/SIGNIFICANCE: Despite a clear variation in morphology, interspecific differences were generally very small, and did only arise in spring, with long-distance migrants (>5000 km: osprey and Western marsh-harrier being faster than species that migrate shorter distances (Egyptian vulture and short-toed eagle. Our results suggest that the most important factor explaining hourly variation in flight speed is time of day, while at a daily scale, tailwind support is the most important factor explaining variation in daily distance, raising new questions about the consequences of possible future changes in worldwide wind patterns.

Physicians' Migration: Perceptions of Pakistani Medical Students.

Science.gov (United States)

Hossain, Nazli; Shah, Nusrat; Shah, Tahira; Lateef, Sidra Binte

2016-08-01

To study the perceptions of medical students about factors responsible for physicians'migration. Cross-sectional survey. Dow Medical College and Civil Hospital, Karachi, from April to May 2015. Aself-administered structured questionnaire was used including demographic details, attitudes about push and pull factors of migration, and reasons for migrating or not migrating abroad. Final year students and interns were included. Likert scale from 1 to 4 (1=strongly disagree to 4=strongly agree) was used to assess attitudes. Data was analyzed by SPSS version 16. Atotal of 240 medical students, mostly females (n=181, 75%) (60% final year and 40% interns), participated in the study. Majority wished to go abroad (n=127; 54%) with United States being the favourite destination (n=80; 66.1%) and internal medicine fields being the preferred choice for specialization (n=126; 54%). The major pull factors were better quality of postgraduate education abroad (n=110; 48.2%) and economic prospects (80; 35.2%); while the push factors were a weak healthcare system (n=219; 94.3%), inadequate salary structure (n=205; 88.3%), insecurity (n=219; 93.9%) and increasing religious intolerance in Pakistan (n=183; 78.5%). This survey highlights the continuing trend of physician migration from Pakistan owing to an interplay of various push and pull factors. Majority of our medical students wish to migrate, mainly due to low salaries, poor job structure, and insecurity. Urgent interventions are required to reverse this trend of medical brain-drain.

Kaempferol inhibits the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes by blocking activation of the MAPK pathway.

Science.gov (United States)

Pan, Dongmei; Li, Nan; Liu, Yanyan; Xu, Qiang; Liu, Qingping; You, Yanting; Wei, Zhenquan; Jiang, Yubao; Liu, Minying; Guo, Tianfeng; Cai, Xudong; Liu, Xiaobao; Wang, Qiang; Liu, Mingling; Lei, Xujie; Zhang, Mingying; Zhao, Xiaoshan; Lin, Changsong

2018-02-01

In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLSs) play an essential role in cartilage destruction. Aggressive migration and invasion by FLSs significantly affect RA pathology. Kaempferol has been shown to inhibit cancer cell migration and invasion. However, the effects of kaempferol on RA FLSs have not been investigated. Our study aimed to determine the effects of kaempferol on RA both in vitro and in vivo. In vitro, cell migration and invasion were measured using scratch assays and the Boyden chamber method, respectively. The cytoskeletal reorganization of RA FLSs was evaluated by immunofluorescence staining. Matrix metalloproteinase (MMP) levels were measured by real-time PCR, and protein expression levels were measured by western blotting. In vivo, the effects of kaempferol were evaluated in mice with CIA. The results showed that kaempferol reduced migration, invasion and MMP expression in RA FLSs. In addition, we demonstrated that kaempferol inhibited reorganization of the actin cytoskeleton during cell migration. Moreover, kaempferol dramatically suppressed tumor necrosis factor (TNF)-α-induced MAPK activation without affecting the expression of TNF-α receptors. We also demonstrated that kaempferol attenuated the severity of arthritis in mice with CIA. Taken together, these results suggested that kaempferol inhibits the migration and invasion of FLSs in RA by blocking MAPK pathway activation without affecting the expression of TNF-α receptors. Copyright © 2017 Elsevier B.V. All rights reserved.

The relationship between affective factors and the academic ...

African Journals Online (AJOL)

The purpose of this study is to investigate the relationship between affective factors and the academic achievement of students at the University of Venda. To this end, self-concept, motivation and attitude are the affective factors selected for the study. The general aim of the study is to determine the role of self-concept, ...

Hypoxia-induced mitogenic factor enhances angiogenesis by promoting proliferation and migration of endothelial cells

International Nuclear Information System (INIS)

Tong Qiangsong; Zheng Liduan; Li Bo; Wang Danming; Huang Chuanshu; Matuschak, George M.; Li Dechun

2006-01-01

Our previous studies have indicated that hypoxia-induced mitogenic factor (HIMF) has angiogenic properties in an in vivo matrigel plug model and HIMF upregulates expression of vascular endothelial growth factor (VEGF) in mouse lungs and cultured lung epithelial cells. However, whether HIMF exerts angiogenic effects through modulating endothelial cell function remains unknown. In this study, mouse aortic rings cultured with recombinant HIMF protein resulted in enhanced vascular sprouting and increased endothelial cell spreading as confirmed by Dil-Ac-LDL uptake, von Willebrand factor and CD31 staining. In cultured mouse endothelial cell line SVEC 4-10, HIMF dose-dependently enhanced cell proliferation, in vitro migration and tubulogenesis, which was not attenuated by SU1498, a VEGFR2/Flk-1 receptor tyrosine kinase inhibitor. Moreover, HIMF stimulation resulted in phosphorylation of Akt, p38 and ERK1/2 kinases in SVEC 4-10 cells. Treatment of mouse aortic rings and SVEC 4-10 cells with LY294002, but not SB203580, PD098059 or U0126, abolished HIMF-induced vascular sprouting and angiogenic responses. In addition, transfection of a dominant-negative mutant of phosphatidylinositol 3-kinase (PI-3K), Δp85, blocked HIMF-induced phosphorylation of Akt, endothelial activation and tubulogenesis. These results indicate that HIMF enhances angiogenesis by promoting proliferation and migration of endothelial cells via activation of the PI-3K/Akt pathways

The benefits and caveats of international nurse migration

Directory of Open Access Journals (Sweden)

Hongyan Li

2014-09-01

Full Text Available Worldwide, there is a dramatic shortage of nurses. An increase in the migration of nurses from their home countries to recipient countries is having a global effect on the healthcare system. This global phenomenon stems from historical, economical, social, and political factors. Migration has a significant impact on both the individual and national level. This article summarizes the factors that contribute to nurse migration form the perspective of the source and recipient countries. Additionally, the impacts and issues surrounding nurse migration were also analyzed.

International migration: a global challenge.

Science.gov (United States)

Martin, P; Widgren, J

1996-04-01

Trends in international migration are presented in this multiregional analysis. Seven of the world's wealthiest countries have about 33% of the world's migrant population, but under 16% of the total world population. Population growth in these countries is substantially affected by the migrant population. The migration challenge is external and internal. The external challenge is to balance the need for foreign labor and the commitment to human rights for those migrants seeking economic opportunity and political freedom. The internal challenge is to assure the social adjustment of immigrants and their children and to integrate them into society as citizens and future leaders. Why people cross national borders and how migration flows are likely to evolve over the next decades are explained. This report also presents some ways that countries can manage migration or reduce the pressures which force people to migrate. It is recommended that receiving nations control immigration by accelerating global economic growth and reducing wars and human rights violations. This report examines the impact of immigration on international trade, aid, and direct intervention policies. Although migration is one of the most important international economic issues, it is not coordinated by an international group. The European experience indicates that it is not easy to secure international cooperation on issues that affect national sovereignty. It is suggested that countries desiring control of their borders should remember that most people never cross national borders to live or work in another country, that 50% of the world's migrants move among developing countries, and that countries can shift from being emigration to immigration countries. The author suggests that sustained reductions in migration pressure are a better alternative than the "quick fixes" that may invite the very much feared mass and unpredictable movements.

Stem cell factor supports migration in canine mesenchymal stem cells.

Science.gov (United States)

Enciso, Nathaly; Ostronoff, Luciana L K; Mejías, Guillermo; León, Leticia G; Fermín, María Luisa; Merino, Elena; Fragio, Cristina; Avedillo, Luis; Tejero, Concepción

2018-03-01

Adult Mesenchymal Stem Cells (MSC) are cells that can be defined as multipotent cells able to differentiate into diverse lineages, under appropriate conditions. These cells have been widely used in regenerative medicine, both in preclinical and clinical settings. Initially discovered in bone marrow, MSC can now be isolated from a wide spectrum of adult and foetal tissues. Studies to evaluate the therapeutic potential of these cells are based on their ability to arrive to damaged tissues. In this paper we have done a comparative study analyzing proliferation, surface markers and OCT4, SOX9, RUNX2, PPARG genes expression in MSC cells from Bone marrow (BMMSC) and Adipose tissue (ASC). We also analyzed the role of Stem Cell Factor (SCF) on MSC proliferation and on ASCs metalloproteinases MMP-2, MMP-9 secretion. Healthy dogs were used as BMMSC donors, and ASC were collected from omentum during elective ovariohysterectomy surgery. Both cell types were cultured in IMDM medium with or without SCF, 10% Dog Serum (DS), and incubated at 38 °C with 5% CO2. Growth of BMMSCs and ASCs was exponential until 25-30 days. Flow citometry of MSCs revealed positive results for CD90 and negative for CD34, CD45 and MCH-II. Genes were evaluated by RT-PCR and metalloproteinases by zymografy. Our findings indicate morphological and immunological similarities as well as expression of genes from both origins on analyzed cells. Furthermore, SCF did not affect proliferation of MSCs, however it up-regulated MMP-2 and MMP-9 secretion in ASCs. These results suggest that metalloproteinases are possibly essential molecules pivoting migration.

Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function.

Science.gov (United States)

Poulose, Shibu M; Miller, Marshall G; Scott, Tammy; Shukitt-Hale, Barbara

2017-11-01

Adult neurogenesis, a complex process by which stem cells in the hippocampal brain region differentiate and proliferate into new neurons and other resident brain cells, is known to be affected by many intrinsic and extrinsic factors, including diet. Neurogenesis plays a critical role in neural plasticity, brain homeostasis, and maintenance in the central nervous system and is a crucial factor in preserving the cognitive function and repair of damaged brain cells affected by aging and brain disorders. Intrinsic factors such as aging, neuroinflammation, oxidative stress, and brain injury, as well as lifestyle factors such as high-fat and high-sugar diets and alcohol and opioid addiction, negatively affect adult neurogenesis. Conversely, many dietary components such as curcumin, resveratrol, blueberry polyphenols, sulforaphane, salvionic acid, polyunsaturated fatty acids (PUFAs), and diets enriched with polyphenols and PUFAs, as well as caloric restriction, physical exercise, and learning, have been shown to induce neurogenesis in adult brains. Although many of the underlying mechanisms by which nutrients and dietary factors affect adult neurogenesis have yet to be determined, nutritional approaches provide promising prospects to stimulate adult neurogenesis and combat neurodegenerative diseases and cognitive decline. In this review, we summarize the evidence supporting the role of nutritional factors in modifying adult neurogenesis and their potential to preserve cognitive function during aging. © 2017 American Society for Nutrition.

Adjusting the general growth balance method for migration

OpenAIRE

Hill, Kenneth; Queiroz, Bernardo

2010-01-01

Death distribution methods proposed for death registration coverage by comparison with census age distributions assume no net migration. This assumption makes it problematic to apply these methods to sub-national and national populations affected by substantial net migration. In this paper, we propose and explore a two-step process in which the Growth Balance Equation is first used to estimate net migration rates, using a model of age-specific migration, and then it is used to compare the obs...

International migration desires related to subjective well-being

OpenAIRE

Cai, Ruohong; Esipova, Neli; Oppenheimer, Michael; Feng, Shuaizhang

2014-01-01

Previous research on the determinants of international migration has largely focused on objective factors, such as income. We instead use subjective well-being (SWB) to explain international migration desires, an expressed willingness to migrate. We find that individuals with higher SWB have lower international migration desires. At the individual level, the SWB-migration relationship appears to be more robust than the income-migration relationship. At the country level, national average SWB ...

Abdominally implanted satellite transmitters affect reproduction and survival rather than migration of large shorebirds

Science.gov (United States)

Hooijmeijer, Jos C. E. W.; Gill, Robert E.; Mulcahy, Daniel M.; Tibbitts, T. Lee; Kentie, Rosemarie; Gerritsen, Gerrit J.; Bruinzeel, Leo W.; Tijssen, David C.; Harwood, Christopher M.; Piersma, Theunis

2014-01-01

Satellite telemetry has become a common technique to investigate avian life-histories, but whether such tagging will affect fitness is a critical unknown. In this study, we evaluate multi-year effects of implanted transmitters on migratory timing and reproductive performance in shorebirds. Shorebirds increasingly are recognized as good models in ecology and evolution. That many of them are of conservation concern adds to the research responsibilities. In May 2009, we captured 56 female Black-tailed Godwits Limosa limosa limosa during late incubation in The Netherlands. Of these, 15 birds were equipped with 26-g satellite transmitters with a percutaneous antenna (7.8 % ± 0.2 SD of body mass), surgically implanted in the coelom. We compared immediate nest survival, timing of migration, subsequent nest site fidelity and reproductive behaviour including egg laying with those of the remaining birds, a comparison group of 41 females. We found no effects on immediate nest survival. Fledging success and subsequent southward and northward migration patterns of the implanted birds conformed to the expectations, and arrival time on the breeding grounds in 2010–2012 did not differ from the comparison group. Compared with the comparison group, in the year after implantation, implanted birds were equally faithful to the nest site and showed equal territorial behaviour, but a paucity of behaviours indicating nests or clutches. In the 3 years after implantation, the yearly apparent survival of implanted birds was 16 % points lower. Despite intense searching, we found only three eggs of two implanted birds; all were deformed. A similarly deformed egg was reported in a similarly implanted Whimbrel Numenius phaeopus returning to breed in central Alaska. The presence in the body cavity of an object slightly smaller than a normal egg may thus lead to egg malformation and, likely, reduced egg viability. That the use of implanted satellite transmitters in these large shorebirds

Conservation physiology of animal migration

Science.gov (United States)

Lennox, Robert J.; Chapman, Jacqueline M.; Souliere, Christopher M.; Tudorache, Christian; Wikelski, Martin; Metcalfe, Julian D.; Cooke, Steven J.

2016-01-01

Migration is a widespread phenomenon among many taxa. This complex behaviour enables animals to exploit many temporally productive and spatially discrete habitats to accrue various fitness benefits (e.g. growth, reproduction, predator avoidance). Human activities and global environmental change represent potential threats to migrating animals (from individuals to species), and research is underway to understand mechanisms that control migration and how migration responds to modern challenges. Focusing on behavioural and physiological aspects of migration can help to provide better understanding, management and conservation of migratory populations. Here, we highlight different physiological, behavioural and biomechanical aspects of animal migration that will help us to understand how migratory animals interact with current and future anthropogenic threats. We are in the early stages of a changing planet, and our understanding of how physiology is linked to the persistence of migratory animals is still developing; therefore, we regard the following questions as being central to the conservation physiology of animal migrations. Will climate change influence the energetic costs of migration? Will shifting temperatures change the annual clocks of migrating animals? Will anthropogenic influences have an effect on orientation during migration? Will increased anthropogenic alteration of migration stopover sites/migration corridors affect the stress physiology of migrating animals? Can physiological knowledge be used to identify strategies for facilitating the movement of animals? Our synthesis reveals that given the inherent challenges of migration, additional stressors derived from altered environments (e.g. climate change, physical habitat alteration, light pollution) or interaction with human infrastructure (e.g. wind or hydrokinetic turbines, dams) or activities (e.g. fisheries) could lead to long-term changes to migratory phenotypes. However, uncertainty remains

Labour Migrations of Bulgarians from Ukraine to the European Union Today and Tomorrow: Factors and Forecasts

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Alexander Ganchev

2011-08-01

Full Text Available Labour migrations from Ukraine to the European Union are closely connected with the issues of interrelations between EU metropolitan countries and their Diasporas in Ukraine. Labour migration developments in independent Ukraine after 1991 have been moving towards their intensification. Migration trends among the Bulgarian Diaspora of South-Western Ukraine gained specific characteristics in the period of the world economic crisis. The enlargement of the EU in 2004 and 2007 led to the transformations in the preferences and choice factors of labour migrants, representatives of the Bulgarian Diaspora, while choosing the destination country in the EU. As a metropolitan country, Bulgaria has focused its policy on attracting its Diaspora groups, seeing them as labour and demographic potential for further development. This point of view is justified in many respects, though metropolitan country efforts must also be directed to the support of the Diaspora and its social, psychological, cultural and linguistic features.

Connective tissue growth factor is activated by gastrin and involved in gastrin-induced migration and invasion.

Science.gov (United States)

Bhandari, Sabin; Bakke, Ingunn; Kumar, J; Beisvag, Vidar; Sandvik, Arne K; Thommesen, Liv; Varro, Andrea; Nørsett, Kristin G

2016-06-17

Connective tissue growth factor (CTGF) has been reported in gastric adenocarcinoma and in carcinoid tumors. The aim of this study was to explore a possible link between CTGF and gastrin in gastric epithelial cells and to study the role of CTGF in gastrin induced migration and invasion of AGS-GR cells. The effects of gastrin were studied using RT-qPCR, Western blot and assays for migration and invasion. We report an association between serum gastrin concentrations and CTGF abundancy in the gastric corpus mucosa of hypergastrinemic subjects and mice. We found a higher expression of CTGF in gastric mucosa tissue adjacent to tumor compared to normal control tissue. We showed that gastrin induced expression of CTGF in gastric epithelial AGS-GR cells via MEK, PKC and PKB/AKT pathways. CTGF inhibited gastrin induced migration and invasion of AGS-GR cells. We conclude that CTGF expression is stimulated by gastrin and involved in remodeling of the gastric epithelium. Copyright © 2016 Elsevier Inc. All rights reserved.

MIGRATION IMPACT ON ECONOMICAL SITUATION

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Virginia COJOCARU

2016-01-01

Full Text Available This paper presents recent trends and flows of labor migration and its impact on economic and social life. Main aim of this research sets up the influence of the migration on the European economics and its competitiveness. Methods of research are: method of comparison, analysis method, method of deduction, method of statistics, modeling method. The economic impact of migration has been intensively studied but is still often driven by ill-informed perceptions, which, in turn, can lead to public antagonism towards migration. These negative views risk jeopardising efforts to adapt migration policies to the new economic and demographic challenges facing many countries. Migration Policy looks at the evidence for how immigrants affect the economy in three main areas: The labour market, public purse and economic growth. In Europe, the scope of labour mobility greatly increased within the EU/EFTA zones following the EU enlargements of 2004, 2007 and 2014-2015. This added to labour markets’ adjustment capacity. Recent estimates suggest that as much as a quarter of the asymmetric labour market shock – that is occurring at different times and with different intensities across countries – may have been absorbed by migration within a year.

[Role of connective tissue growth factor (CTGF) in proliferation and migration of pancreatic cancer cells].

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Bai, Yu-chun; Kang, Quan; Luo, Qing; Wu, Dao-qi; Ye, Wei-xia; Lin, Xue-mei; Zhao, Yong

2011-10-01

To explore the expression of connective tissue growth factor (CTGF) in pancreatic cancer and its influence on the proliferation and migration of cancer cells. The expression of CTGF in pancreatic cell line PANC-1 cells was analyzed by real-time PCR and in pancreatic carcinoma (50 cases) tissues by immunohistochemistry. The ability of proliferation and migration in vitro of PANC-1 cells was tested by MTT assay, scratch test and Boyden chamber test after the CTGF gene was overexpressed by Ad5-CTGF or silenced with Ad5-siCTGF transfection. CTGF was overexpressed in both pancreatic cancer cells and tissues. Overxpression of CTGF leads to increased proliferation and migration of PANC-1 cells. The CTGF-transfected PANC-1 cells showed apparent stronger proliferation ability and scratch-repair ability than that of empty vector controls. The results of Boyden chamber test showed that there were 34 cells/field (200× magnificantion) of the CTGF-transfected overexpressing cells, much more than the 11 cells/field of the empty vector control cells; and 6 cells/microscopic field of the Ad5-siCTGF-transfected silenced cells, much less than the 15 cells/field of the control cells. CTGF is overexpressed in both pancreatic cancer cells in vitro and in vivo, indicating that it may play an important role in the cell proliferation and migration in pancreatic cancer.

Factors Affecting Green Residential Building Development: Social Network Analysis

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Xiaodong Yang

2018-05-01

Full Text Available Green residential buildings (GRBs are one of the effective practices of energy saving and emission reduction in the construction industry. However, many real estate developers in China are less willing to develop GRBs, because of the factors affecting green residential building development (GRBD. In order to promote the sustainable development of GRBs in China, this paper, based on the perspective of real estate developers, identifies the influential and critical factors affecting GRBD, using the method of social network analysis (SNA. Firstly, 14 factors affecting GRBD are determined from 64 preliminary factors of three main elements, and the framework is established. Secondly, the relationships between the 14 factors are analyzed by SNA. Finally, four critical factors for GRBD, which are on the local economy development level, development strategy and innovation orientation, developer’s acknowledgement and positioning for GRBD, and experience and ability for GRBD, are identified by the social network centrality test. The findings illustrate the key issues that affect the development of GRBs, and provide references for policy making by the government and strategy formulation by real estate developers.

Rural to urban migration and changes in cardiovascular risk factors in Tanzania: a prospective cohort study

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Tamin Bushiri

2010-05-01

Full Text Available Abstract Background High levels of rural to urban migration are a feature of most African countries. Our aim was to investigate changes, and their determinants, in cardiovascular risk factors on rural to urban migration in Tanzania. Methods Men and women (15 to 59 years intending to migrate from Morogoro rural region to Dar es Salaam for at least 6 months were identified. Measurements were made at least one week but no more than one month prior to migration, and 1 to 3 monthly after migration. Outcome measures included body mass index, blood pressure, fasting lipids, and self reported physical activity and diet. Results One hundred and three men, 106 women, mean age 29 years, were recruited and 132 (63.2% followed to 12 months. All the figures presented here refer to the difference between baseline and 12 months in these 132 individuals. Vigorous physical activity declined (79.4% to 26.5% in men, 37.8% to 15.6% in women, p -1 respectively, p -1, p = 0.01, and triglycerides fell (0.31 mmoll-1, p = 0.034. Blood pressure appeared to fall in both men and women. For example, in men systolic blood pressure fell by 5.4 mmHg, p = 0.007, and in women by 8.6 mmHg, p = 0.001. Conclusion The lower level of physical activity and increasing weight will increase the risk of diabetes and cardiovascular disease. However, changes in diet were mixed, and may have contributed to mixed changes in lipid profiles and a lack of rise in blood pressure. A better understanding of the changes occurring on rural to urban migration is needed to guide preventive measures.

Factors affecting dignity of patients with multiple sclerosis.

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Sharifi, Simin; Borhani, Fariba; Abbaszadeh, Abbas

2016-12-01

MS is one of the most common chronic diseases of the nervous system. Apart from disease progression, other complications such as unemployment, separation and divorce could potentially threat patients' dignity. Most of the previous studies have been done of maintaining patients' dignity in interaction with healthcare team, but studies on affecting factors of dignity in chronic patients in the society and in interaction with usual people are scarce. We aimed to investigate factors affecting dignity of Iranian patients with MS in daily living and in interaction of them with the society. In this qualitative study, 13 patients with multiple sclerosis were chosen by purposive sampling and semi-structured interviews were conducted until data saturation. The study was done in Tehran, the capital city of Iran. Factors affecting dignity were classified as 'personal factors' and 'social factors'. Personal factors consist of the following subcategories: patients' communication with self, patients' knowledge, patients' values and beliefs and patients' resources. Social factors include others' communication with patients, social knowledge, social values and beliefs and social resources. Multiple personal and social factors interfere in perceived patient dignity. In fact, interaction between personal and social factors can be influential in final perceived dignity. By focusing on whole aspects of the patients' lives, we can identify dignity-promoting or dignity-threatening factors and help patients maintain their dignity by taking appropriate measures for moderating threatening factors and improving dignity enhancing ones. © 2016 Nordic College of Caring Science.

Engendering climate change-induced migration

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Caretta, Martina Angela; Miletto, Michela

2017-04-01

Climate change leads to increased climate variability, which is manifest in extreme weather events such as floods and droughts. These put at stake agricultural productivity, forestry, inland fisheries, aquaculture, water supply and sanitation which in turn hamper poorest householdś self-sufficiency and capability to cope with risks. Due to the risk of losing or the actual loss of livelihood, farmers in the Global South must look for alternative strategies to diversify risk. Migration is one of those strategies, which that can be seen either as an adaptive measure or an indicator of limits to adaptation to environmental stress. 60% of young migrants live in the Global South (UN, 2013). Many internally displaced people in the world are under the age of 18, some move with their families, other, mostly in South Asia and West Africa, migrate alone. Youth, as all migrants, are seeking better economic opportunities to support themselves and their families. Migration is a gendered process which plays out differently in diverse societies depending on local cultural norms that do not only affect and are affected by gender roles, but also by age, class and ethnicity. Threats to water availability, access and water hazards have diverse impacts on men and women. The link gender and climate-induced migration is still under investigation and few studies provide concrete country specific examples of this phenomenon. Our paper will present a state of the art literature review around climate-induced migration in the Global South from a gender perspective showing how meńs and womeńs migratory decisions, patterns and outcomes differ at the stage pre-during post migration.

Migration signatures across the decades: Net migration by age in U.S. counties, 1950-2010

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Richelle L. Winkler

2015-05-01

Full Text Available Background: Migration is the primary population redistribution process in the United States. Selective migration by age, race/ethnic group, and spatial location governs population integration, affects community and economic development, contributes to land use change, and structures service needs. Objective: Delineate historical net migration patterns by age, race/ethnic, and rural-urban dimensions for United States counties. Methods: Net migration rates by age for all US counties are aggregated from 1950−2010, summarized by rural-urban location and compared to explore differential race/ethnic patterns of age-specific net migration over time. Results: We identify distinct age-specific net migration 'signatures' that are consistent over time within county types, but different by rural-urban location and race/ethnic group. There is evidence of moderate population deconcentration and diminished racial segregation between 1990 and 2010. This includes a net outflow of Blacks from large urban core counties to suburban and smaller metropolitan counties, continued Hispanic deconcentration, and a slowdown in White counterurbanization. Conclusions: This paper contributes to a fuller understanding of the complex patterns of migration that have redistributed the U.S. population over the past six decades. It documents the variability in county age-specific net migration patterns both temporally and spatially, as well as the longitudinal consistency in migration signatures among county types and race/ethnic groups.

Individual Decisions to Migrate During Civil Conflict

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Bohra-Mishra, Pratikshya; Massey, Douglas S.

2012-01-01

The existing literature on forced migration limits our understanding of how violence affects migration to competing destinations. This article adds to the literature on forced migration by studying how armed violence during a period of civil conflict in south-central Nepal influenced the likelihood of local, internal, and international migration. We find that violence has a nonlinear effect on migration, such that low to moderate levels of violence reduce the odds of movement, but when violence reaches high levels, the odds of movement increase. We also find that the effect of violence on mobility increases as the distance of the move increases. When we consider the influence of violence on microlevel decision-making, we find that the effects of individual and household-level determinants were mostly consistent with hypotheses derived from contemporary theories of voluntary migration and that no predictor of migration influenced the decision to migrate differently in the presence of violence. PMID:21541805

Evolution of Mammalian Migrations for Refuge, Breeding, and Food

OpenAIRE

Gnanadesikan, Gitanjali E.; Pearse, William; Shaw, Allison K.

2017-01-01

Abstract Many organisms migrate between distinct habitats, exploiting variable resources while profoundly affecting ecosystem services, disease spread, and human welfare. However, the very characteristics that make migration captivating and significant also make it difficult to study, and we lack a comprehensive understanding of which species migrate and why. Here we show that, among mammals, migration is concentrated within Cetacea and Artiodactyla but also diffusely spread throughout the cl...

Empirical research on international environmental migration: a systematic review.

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Obokata, Reiko; Veronis, Luisa; McLeman, Robert

2014-01-01

This paper presents the findings of a systematic review of scholarly publications that report empirical findings from studies of environmentally-related international migration. There exists a small, but growing accumulation of empirical studies that consider environmentally-linked migration that spans international borders. These studies provide useful evidence for scholars and policymakers in understanding how environmental factors interact with political, economic and social factors to influence migration behavior and outcomes that are specific to international movements of people, in highlighting promising future research directions, and in raising important considerations for international policymaking. Our review identifies countries of migrant origin and destination that have so far been the subject of empirical research, the environmental factors believed to have influenced these migrations, the interactions of environmental and non-environmental factors as well as the role of context in influencing migration behavior, and the types of methods used by researchers. In reporting our findings, we identify the strengths and challenges associated with the main empirical approaches, highlight significant gaps and future opportunities for empirical work, and contribute to advancing understanding of environmental influences on international migration more generally. Specifically, we propose an exploratory framework to take into account the role of context in shaping environmental migration across borders, including the dynamic and complex interactions between environmental and non-environmental factors at a range of scales.

Factor affecting Agrobacterium -mediated transformation of rice ...

African Journals Online (AJOL)

Potato is a very important food crop and is adversely affected by fungus. Agrobacterium-mediated transformation can play an important role in the improvement of potato. The present study was conducted to optimize the different factors affecting Agrobacterium-mediated transformation of chitinase gene. Nodes were used as ...

Do migrating cells need a nucleus?

Science.gov (United States)

Hawkins, Rhoda J

2018-03-05

How the nucleus affects cell polarity and migration is unclear. In this issue, Graham et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201706097) show that enucleated cells polarize and migrate in two but not three dimensions and propose that the nucleus is a necessary component of the molecular clutch regulating normal mechanical responses. © 2018 Hawkins.

Rural migration in Nevada: Lincoln County. Phase 1, 1992--1993

Energy Technology Data Exchange (ETDEWEB)

Soden, D.L.; Carns, D.E.; Mosser, D.; Conary, J.S.; Ansell, J.P.

1993-12-31

The principal objective of this project was to develop insight into the scope of migration of working age Nevadans out of their county of birth; including the collection of data on their skill levels, desire to out or in-migrate, interactions between families of migratory persons, and the impact that the proposed high-level nuclear waste repository at Yucca mountain might have on their individual, and collective, decisions to migrate and return. The initial phase of this project reported here was conducted in 1992 and 1993 in Lincoln County, Nevada, one of the counties designated as ``affected`` by the proposed repository program. The findings suggest that a serious out-migration problem exists in Lincoln County, and that the Yucca mountain project will likely affect decisions relating to migration patterns in the future.

Factors affecting patient dose in diagnostic radiology

International Nuclear Information System (INIS)

Poletti, J.L.

1994-03-01

The report, Factors Affecting Patient Dose in Diagnostic Radiology is divided into three main sections. Part one is introductory and covers the basic principles of x-ray production and image formation. It includes discussion of x-ray generators and x-ray tubes, radiation properties and units, specification and measurement of x-ray beams, methods of patient dose measurement, radiation effects, radiation protection philosophy and finally the essentials of imaging systems. Part two examines factors affecting the x-ray output of x-ray machines and the characteristics of x-ray beams. These include the influence of heat ratings, kVp, waveform, exposure timer, filtration, focus-film distance, beam intensity distribution, x-ray tube age and focal spot size. Part three examines x-ray machine, equipment and patient factors which affect the dose received by individual patients. The factors considered include justification of examinations, choice of examination method, film/screen combinations, kVp, mAs, focus-film distance, collimation and field size, exposure time, projection, scatter, generator calibration errors, waveform, filtration, film processing and patient size. The patient dose implications of fluoroscopy systems, CT scanners, special procedures and mammography are also discussed. The report concludes with a brief discussion of patient dose levels in New Zealand and dose optimisation. 104 refs., 32 figs., 27 tabs

Overview of factors affecting the leachability of nuclear waste forms

International Nuclear Information System (INIS)

Stone, J.A.

1980-01-01

An overview of various factors that affect the leachability of nuclear waste forms is presented. The factors affect primarily the leaching system (temperature, for example), the leachant (pH, for example), or the solid being leached (surface condition, for example). A qualitative understanding exists of the major factors affecting leaching, but further studies are needed to establish leaching mechanisms and develop predictive models. 67 refs

Modelling of far-field gas migration from a deep radioactive waste repository

International Nuclear Information System (INIS)

Rodwell, W.R.; Nash, P.J.

1992-01-01

In assessing the post-closure safety of a deep radioactive waste repository, it is necessary to show that gas generated within the repository can migrate away, through the far-field geology, without affecting repository safety. This paper discusses the contribution of various mechanisms to gas migration through the far field; for example, diffusion of dissolved gas versus gas-phase movement, and bubble flow versus formation of a connected gas stream. It outlines different approaches to modelling gas movement from a repository, with simple semi-analytical models furnishing physical insights into the factors controlling gas migration in the absence of directly applicable experimental data, and more comprehensive numerical computations allowing the exploration of more detailed behaviour when appropriate data is obtained. If gas can induce groundwater movement, this could accelerate the transport of water-borne contaminants. Processes by which this could occur are noted, and the current status of work on possible effects of gas migration on groundwater movement in fractured hard rocks is indicated. 14 refs., 4 figs

Migration as a Context-Dependent Dynamic in a World of Global Inequalities

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Jana Sládková

2011-11-01

Full Text Available Global migration is a topic of utmost importance in psychological research. As over 200 million people are on the move across national borders, and many more within their own countries, the processes of these migrations must be examined from different points of view and from different geographical locations. The articles in this special journal issue pointedly illustrate the role of international, national, community, and individual factors that shape these migrations. One cross-cutting theme is the importance of studying how multiple levels of context affect immigrant and migrant experiences. All six contributions, collectively, enrich the often individual-centric psychological literature. Issues of resilience and spaces of resistance emerged as a second cross-cutting theme, pointing to new directions for acculturation research and intervention. The challenge of recognizing diversity within migrant communities and among migration patterns is a third cross-cutting theme essential to address as we work toward a more equal world in which people can more freely chose whether to stay or leave their homes.

SOCIO-ECONOMIC FACTORS AFFECTING APPLE PRODUCTION ...

African Journals Online (AJOL)

ACSS

Research Organisation scientists working directly with apple farmers ... be productive up to 40 years, it was more realistic to consider .... to determine the factors that affect apple production. ..... profit maximising model using flexible production ...

Individual versus Household Migration Decision Rules: Gender and Marital Status Differences in Intentions to Migrate in South Africa.

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Gubhaju, Bina; De Jong, Gordon F

2009-03-01

This research tests the thesis that the neoclassical micro-economic and the new household economic theoretical assumptions on migration decision-making rules are segmented by gender, marital status, and time frame of intention to migrate. Comparative tests of both theories within the same study design are relatively rare. Utilizing data from the Causes of Migration in South Africa national migration survey, we analyze how individually held "own-future" versus alternative "household well-being" migration decision rules effect the intentions to migrate of male and female adults in South Africa. Results from the gender and marital status specific logistic regressions models show consistent support for the different gender-marital status decision rule thesis. Specifically, the "maximizing one's own future" neoclassical microeconomic theory proposition is more applicable for never married men and women, the "maximizing household income" proposition for married men with short-term migration intentions, and the "reduce household risk" proposition for longer time horizon migration intentions of married men and women. Results provide new evidence on the way household strategies and individual goals jointly affect intentions to move or stay.

Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid–stimulated migration of murine osteosarcoma LM8 cells

Energy Technology Data Exchange (ETDEWEB)

Kubohara, Yuzuru, E-mail: ykuboha@juntendo.ac.jp [Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi 371-8512 (Japan); Department of Health Science, Juntendo University Graduate School of Health and Sports Science, Inzai 270-1695 (Japan); Komachi, Mayumi [Department of Molecular and Cellular Biology, Institute for Molecular and Cellular Regulation (IMCR), Gunma University, Maebashi 371-8512 (Japan); Department of Radiation Oncology, Gunma University Graduate School of Medicine, Maebashi 371-8511 (Japan); Homma, Yoshimi [Department of Biomolecular Science, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960-1295 (Japan); Kikuchi, Haruhisa; Oshima, Yoshiteru [Laboratory of Natural Product Chemistry, Tohoku University Graduate School of Pharmaceutical Sciences, Aoba-yama, Aoba-ku, Sendai 980-8578 (Japan)

2015-08-07

Osteosarcoma is a common metastatic bone cancer that predominantly develops in children and adolescents. Metastatic osteosarcoma remains associated with a poor prognosis; therefore, more effective anti-metastatic drugs are needed. Differentiation-inducing factor-1 (DIF-1), −2, and −3 are novel lead anti-tumor agents that were originally isolated from the cellular slime mold Dictyostelium discoideum. Here we investigated the effects of a panel of DIF derivatives on lysophosphatidic acid (LPA)-induced migration of mouse osteosarcoma LM8 cells by using a Boyden chamber assay. Some DIF derivatives such as Br-DIF-1, DIF-3(+2), and Bu-DIF-3 (5–20 μM) dose-dependently suppressed LPA-induced cell migration with associated IC{sub 50} values of 5.5, 4.6, and 4.2 μM, respectively. On the other hand, the IC{sub 50} values of Br-DIF-1, DIF-3(+2), and Bu-DIF-3 versus cell proliferation were 18.5, 7.2, and 2.0 μM, respectively, in LM8 cells, and >20, 14.8, and 4.3 μM, respectively, in mouse 3T3-L1 fibroblasts (non-transformed). Together, our results demonstrate that Br-DIF-1 in particular may be a valuable tool for the analysis of cancer cell migration, and that DIF derivatives such as DIF-3(+2) and Bu-DIF-3 are promising lead anti-tumor agents for the development of therapies that suppress osteosarcoma cell proliferation, migration, and metastasis. - Highlights: • LPA induces cell migration (invasion) in murine osteosarcoma LM8 cells. • DIFs are novel lead anti-tumor agents found in Dictyostelium discoideum. • We examined the effects of DIF derivatives on LPA-induced LM8 cell migration in vitro. • Some of the DIF derivatives inhibited LPA-induced LM8 cell migration.

Factors Affecting Entrepreneurship and Business Sustainability

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Ana Tur-Porcar

2018-02-01

Full Text Available Sustainability is becoming increasingly important for society, and the creation of business ventures is one area where sustainability is critical. We examined the factors affecting actions that are designed to foster business sustainability. These factors are related to the environment, behavior, human relations, and business activity. Based on questionnaire responses from experts, the Analytic Hierarchy Process (AHP method was used to rank sustainable business criteria according to their importance for entrepreneurs starting sustainable businesses. The results indicate that the most important drivers of sustainable entrepreneurship are behavioral factors and business factors. Ethical principles and values, together with competitive intelligence, are crucial for undertaking actions that lead to sustainability.

Psychological distress in torture survivors: pre- and post-migration risk factors in a US sample.

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Song, Suzan J; Kaplan, Charles; Tol, Wietse A; Subica, Andrew; de Jong, Joop

2015-04-01

To investigate the relationships between sociodemographic, pre- and post-migration variables with prevalence of psychological distress and global functioning in a heterogeneous sample of torture survivors. Clients referred from resettlement agencies via the Office of Refugee Resettlement (ORR) to a community clinic in the United States (N = 278) were interviewed with structured, translated questionnaires. Univariate and multivariate logistic regression analyses determined the associations of sociodemographic, pre-, and post-migration risk factors with posttraumatic stress disorder (PTSD), depression, anxiety, and global functioning. Regression data indicate that length of time between arrival in US and clinical services was significantly associated with PTSD and depression; participants receiving services after 1 year of resettlement were more likely to experience PTSD (adjusted OR = 3.29) and depression (adjusted OR = 4.50) than participants receiving services within 1 year. Anxiety was predicted by female gender (adjusted OR = 3.43), age over 40 years (adjusted OR = 3.12), Muslim religion (adjusted OR = 2.64), and receiving medical services (AOR 3.1). Severely impaired global functioning was associated with female gender (adjusted OR = 2.75) and unstable housing status (adjusted OR = 2.21). Findings highlight the importance of examining post-migration variables such as length of time in country prior to receiving services in addition to pre-migration torture history upon relocated torture survivors. Clinicians and policy-makers should be aware of the importance of early mental health screening and intervention on reducing the psychiatric burden associated with torture and forced relocation.

Return Migration as Failure or Success?: The Determinants of Return Migration Intentions Among Moroccan Migrants in Europe.

Science.gov (United States)

de Haas, Hein; Fokkema, Tineke; Fihri, Mohamed Fassi

Different migration theories generate competing hypotheses with regard to determinants of return migration. While neoclassical migration theory associates migration to the failure to integrate at the destination, the new economics of labour migration sees return migration as the logical stage after migrants have earned sufficient assets and knowledge and to invest in their origin countries. The projected return is then likely to be postponed for sustained or indefinite periods if integration is unsuccessful. So, from an indication or result of integration failure return is rather seen as a measure of success. Drawing on recent survey data ( N  = 2,832), this article tests these hypotheses by examining the main determinants of return intention among Moroccan migrants across Europe. The results indicate that structural integration through labour market participation, education and the maintenance of economic and social ties with receiving countries do not significantly affect return intentions. At the same time, investments and social ties to Morocco are positively related, and socio-cultural integration in receiving countries is negatively related to return migration intentions. The mixed results corroborate the idea that there is no uniform process of (return) migration and that competing theories might therefore be partly complementary.

Factors Affecting the Productivity of Government Workers

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Jerry P. Haenisch

2012-01-01

Full Text Available While there have been a variety of studies concerning government worker motivation and productivity, few, if any, studies have focused specifically on state government workers’ perceptions about what factors affect their productivity. With more than 5 million workers employed by state governments in the United States, any improvement in state workplace productivity could have significant financial and service impact for society. In this study, state government workers identified those factors perceived as most affecting their workplace productivity. Data were collected through a survey offered to state government workers in the state of Wyoming. Factor analysis was used to derive key productivity factors from survey responses. The results indicate that state government workers appreciate having freedom and autonomy, like their jobs and the sense of achievement, and welcome teamwork, but feel limited by poor supervision and management, poor communications, and insufficient budgets and staffing. To improve productivity, the workers would eliminate bureaucracy, supervise better, and improve communication.

The role of family decision in internal migration: the case of India.

Science.gov (United States)

Bhattacharyya, B

1985-01-01

This paper analyzes the effects of family decisions and individual decisions on rural-urban migration in India under 2 different rural institutions--family farm and wage labor systems. An analytical framework for explaining family migration decisions reveals that whenever a member of the extended family migrates, he gives up his share in the produce of the family farm. When this happens, the number of adult members on the farm goes down and the total product is affected. 3 case studies of Indian villages are analyzed for this study. 2 empirical relations are examined: 1) if individual migration decisions are predominant, and 2) if family decisions are important in determining the overall flow of migration. Relationships between migration decisions and other variables, such as: 1) number of males in urban areas; 2) urban wages; 3) daily wage rate; 4) average agricultural income; 5) railway distance between rural and urban areas; 6) size of the labor market in destination region; 7) probability that a migrant arriving in an urban area will find a job; and 8) comsumption expenditure, in urban areas estimated by working class consumer price index, are determined. Results show that: 1) the market determined wage variable does not play a very significant role in migration decisions; 2) distance is one of the most important variables in analyzing migration; and 3) the aggregate flow of migration is affected if migration decisions are predominantly family decisions. These findings have relevant policy implications for less developed countries (LDCs), especially because large flows of rural-urban migration in recent years have forced governments to adopt policies for controlling the flows to reduce the burden of unemployment in the urban areas. Government policies affecting rural institutions will have an impact on migration flow; those that lead to a reduction of uncertainty in agriculture will affect average per-capita consumption levels in family farms and hence

Families, children, migration and AIDS.

Science.gov (United States)

Haour-Knipe, Mary

2009-01-01

Migration is very often a family affair, and often involves children, directly or indirectly. It may give rise to better quality of life for an entire family, or to bitter disappointment, and may also increase vulnerability to HIV and AIDS. This review, carried out for the Joint Learning Initiative on Children and AIDS, links the literature on "migration", on "HIV and AIDS" and on "families". Three themes are sketched: (1) As both HIV prevalence and circular migration increase, former migrant workers affected by AIDS may return to their families for care and support, especially at the end of life, often under crisis conditions. Families thus lose promising members, as well as sources of support. However, very little is known about the children of such migrants. (2) Following patterns of migration established for far different reasons, children may have to relocate to different places, sometimes over long distances, if their AIDS-affected parents can no longer care for them. They face the same adaptation challenges as other children who move, but complicated by loss of parent(s), AIDS stigma, and often poverty. (3) The issue of migrant families living with HIV has been studied to some extent, but mainly in developed countries with a long history of migration, and with little attention paid to the children in such families. Difficulties include involuntary separation from family members, isolation and lack of support, disclosure and planning for children's care should the parent(s) die and differences in treatment access within the same family. Numerous research and policy gaps are defined regarding the three themes, and a call is made for thinking about migration, families and AIDS to go beyond description to include resilience theory, and to go beyond prevention to include care.

[The regional context of migration: the case of Tabasco].

Science.gov (United States)

Lezama, J L

1991-09-01

This work contains reflections on regional influences in determination of migratory processes, as distinct from economic and political influences at the national level. The relationship between migration and region implies discussion of the concept of regions and regional hierarchies in relation to the national level. The economic structure of a region and its influence on migration for example is related to characteristics of the same phenomenon at the national level. Migration to Mexico City and Monterrey represents a process of social change that affects all of Mexican society, both because of the regional diversity and large volume of migrants to the 2 cities and because of their importance in Mexico's economic and social development. Migration at the regional level may be determined by forces within that region or by processes at the national or even international level that are beyond local control. The particular mix of resources available in a region and the level of its development compared to other places within the nation strongly affect migratory potential. The concrete case of petroleum activity in the state of Tabasco is an example of the lack of participation at the regional level in design of investment policy. The petroleum boom of the 1960s in Tabasco produced profound economic changes in the region and caused changes in the local power structure. Particularities in the case of Tabasco included a state economy dominated by petroleum activity, deterioration in the agricultural sector accompanied by increased livestock raising, expansion of zones of population expulsion especially where livestock were most dominant, and consolidation of strong migratory flows toward the petroleum zones. External factors in the regional socioeconomic situation included the impacts generated by petroleum activity, while internal factors included the increasing importance of livestock and eclipse of agriculture even before the petroleum boom. Census and survey data

[Perception of residents in world heritage site to the effects of ecological migration: a case study of three migrant resettlement spots in Wulingyuan, Hunan Province of South-central China].

Science.gov (United States)

Wang, Kai; Ou, Yan; Ge, Quan-Sheng

2012-06-01

Based on the investigation in three typical migrant resettlement spots in Wulingyuan Scenic Area, a demonstration analysis was conducted on the residents' perception to the effects of ecological migration on world heritage site. The residents in the 3 spots had great differences in the positive perception to the economic effects of ecological migration, but less differences in the perception to the negative indices. The residents had high identity with the positive socio-cultural effects, but weak perception to the negative effects. The residents in the 3 resettlement spots had obvious differences in the perception to the effects on resources and environment, but mostly agreed that the negative psychological effects were not so obvious. The negative comments were given to the main migration policies. Age, educational level, monthly income, and proportion of tourism input were the main factors affecting the residents' perception, and the way of resettlement as well as the proportion of tourism input also had important effects on the residents' perception. Migration policy was the dominant factor affecting the integral perception of the residents to ecological migration.

Immunohistochemical study of macrophage migration inhibitory factor in rat liver fibrosis induced by thioacetamide

OpenAIRE

Y Hori; S Sato; J Yamate; M Kurasaki

2009-01-01

Macrophage migration inhibitory factor (MIF) is a molecule known to regulate macrophage accumulation at sites of inflammation. To elucidate the role of MIF in progression of liver fibrosis, the immunohistochemical localization of MIF and macrophages in the liver were examined. Male Wistar rats received thioacetamide (TA) injections (200 mg/kg, i.p.) for 1 or 6 weeks. In biochemical and histological tests, it was confirmed that liver fibrosis was induced. In immunohistochemical analyses, the e...

MicroRNA-145 Inhibits Cell Migration and Invasion and Regulates Epithelial-Mesenchymal Transition (EMT) by Targeting Connective Tissue Growth Factor (CTGF) in Esophageal Squamous Cell Carcinoma.

Science.gov (United States)

Han, Qiang; Zhang, Hua-Yong; Zhong, Bei-Long; Wang, Xiao-Jing; Zhang, Bing; Chen, Hua

2016-10-23

BACKGROUND This study investigated the mechanism of miR-145 in targeting connective tissue growth factor (CTGF), which affects the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of ESCC cells. MATERIAL AND METHODS A total of 50 ESCC tissues and their corresponding normal adjacent esophageal tissue samples were collected. Then, miR-145 expression in both ESCC clinical specimens and cell lines was detected using quantitative real-time PCR. CTGF protein was detected using immunohistochemistry. Dual luciferase reporter gene assay was employed to assess the effect of miR-145 on the 3'UTR luciferase activity of CTGF. Eca109 cells were transfected with miR-145 mimics and CTGF siRNA, respectively, and changes in cellular proliferation, migration, and invasion were detected via MTT assay, wound-healing assay, and Transwell assay, respectively. Western blotting assay was used to detect the expression of marker genes related to EMT. RESULTS MiR-145 was significantly down-regulated in ESCC tissues and cell lines compared with normal tissues and cell lines (Ptissues was than in normal adjacent esophageal tissues (Ptissues and cell lines, while the protein expression of CTGF exhibited the opposite trend. MiR-145 inhibited the proliferation, migration, invasiveness, and the EMT process of ESCC cells through targeted regulation of CTGF expression.

Redundant control of migration and adhesion by ERM proteins in vascular smooth muscle cells

International Nuclear Information System (INIS)

Baeyens, Nicolas; Latrache, Iman; Yerna, Xavier; Noppe, Gauthier; Horman, Sandrine; Morel, Nicole

2013-01-01

Highlights: •The three ERM proteins are expressed in vascular smooth muscle cell. •ERM depletion inhibited PDGF-evoked migration redundantly. •ERM depletion increased cell adhesion redundantly. •ERM depletion did not affect PDGF-evoked Ca signal, Rac1 activation, proliferation. •ERM proteins control PDGF-induced migration by regulating adhesion. -- Abstract: Ezrin, radixin, and moesin possess a very similar structure with a C-terminal actin-binding domain and a N-terminal FERM interacting domain. They are known to be involved in cytoskeleton organization in several cell types but their function in vascular smooth muscle cells (VSMC) is still unknown. The aim of this study was to investigate the role of ERM proteins in cell migration induced by PDGF, a growth factor involved in pathophysiological processes like angiogenesis or atherosclerosis. We used primary cultured VSMC obtained from rat aorta, which express the three ERM proteins. Simultaneous depletion of the three ERM proteins with specific siRNAs abolished the effects of PDGF on cell architecture and migration and markedly increased cell adhesion and focal adhesion size, while these parameters were only slightly affected by depletion of ezrin, radixin or moesin alone. Rac1 activation, cell proliferation, and Ca 2+ signal in response to PDGF were unaffected by ERM depletion. These results indicate that ERM proteins exert a redundant control on PDGF-induced VSMC migration by regulating focal adhesion turn-over and cell adhesion to substrate

Redundant control of migration and adhesion by ERM proteins in vascular smooth muscle cells

Energy Technology Data Exchange (ETDEWEB)

Baeyens, Nicolas; Latrache, Iman; Yerna, Xavier [Laboratory of Cell Physiology, IoNS, Université Catholique de Louvain (Belgium); Noppe, Gauthier; Horman, Sandrine [Pôle de Recherche Cardiovasculaire, IREC, Université Catholique de Louvain (Belgium); Morel, Nicole, E-mail: nicole.morel@uclouvain.be [Laboratory of Cell Physiology, IoNS, Université Catholique de Louvain (Belgium)

2013-11-22

Highlights: •The three ERM proteins are expressed in vascular smooth muscle cell. •ERM depletion inhibited PDGF-evoked migration redundantly. •ERM depletion increased cell adhesion redundantly. •ERM depletion did not affect PDGF-evoked Ca signal, Rac1 activation, proliferation. •ERM proteins control PDGF-induced migration by regulating adhesion. -- Abstract: Ezrin, radixin, and moesin possess a very similar structure with a C-terminal actin-binding domain and a N-terminal FERM interacting domain. They are known to be involved in cytoskeleton organization in several cell types but their function in vascular smooth muscle cells (VSMC) is still unknown. The aim of this study was to investigate the role of ERM proteins in cell migration induced by PDGF, a growth factor involved in pathophysiological processes like angiogenesis or atherosclerosis. We used primary cultured VSMC obtained from rat aorta, which express the three ERM proteins. Simultaneous depletion of the three ERM proteins with specific siRNAs abolished the effects of PDGF on cell architecture and migration and markedly increased cell adhesion and focal adhesion size, while these parameters were only slightly affected by depletion of ezrin, radixin or moesin alone. Rac1 activation, cell proliferation, and Ca{sup 2+} signal in response to PDGF were unaffected by ERM depletion. These results indicate that ERM proteins exert a redundant control on PDGF-induced VSMC migration by regulating focal adhesion turn-over and cell adhesion to substrate.

Short-term forecasting of internal migration.

Science.gov (United States)

Frees, E W

1993-11-01

A new methodological approach to the forecasting of short-term trends in internal migration in the United States is introduced. "Panel-data (or longitudinal-data) models are used to represent the relationship between destination-specific out-migration and several explanatory variables. The introduction of this methodology into the migration literature is possible because of some new and improved databases developed by the U.S. Bureau of the Census.... Data from the Bureau of Economic Analysis are used to investigate the incorporation of exogenous factors as variables in the model." The exogenous factors considered include employment and unemployment, income, population size of state, and distance between states. The author concludes that "when one...includes additional parameters that are estimable in longitudinal-data models, it turns out that there is little additional information in the exogenous factors that is useful for forecasting." excerpt

Migration, human capital, and growth in a globalized economy

OpenAIRE

Burzynski, Michal

2016-01-01

This thesis focuses on the implications of past, and hypothetical future movements of people for the prosperity of natives and residents living in the highly developed regions. The first Chapter discusses the welfare impact of migration in the OECD countries by analyzing recent migration flows (net migration between 2000 and 2010), and total stock of migrants in 2010. The importance of different channels, through which migration affects the wellbeing of stayers, is discussed. In the second Ch...

RhoA and RhoC are involved in stromal cell-derived factor-1-induced cell migration by regulating F-actin redistribution and assembly.

Science.gov (United States)

Luo, Jixian; Li, Dingyun; Wei, Dan; Wang, Xiaoguang; Wang, Lan; Zeng, Xianlu

2017-12-01

Stromal cell-derived factor-1 (SDF-1) signaling is important to the maintenance and progression of T-cell acute lymphoblastic leukemia by inducing chemotaxis migration. To identify the mechanism of SDF-1 signaling in the migration of T-ALL, Jurkat acute lymphoblastic leukemia cells were used. Results showed that SDF-1 induces Jurkat cell migration by F-actin redistribution and assembly, which is dependent on Rho activity. SDF-1 induced RhoA and RhoC activation, as well as reactive oxygen species (ROS) production, which was inhibited by Rho inhibitor. The Rho-dependent ROS production led to subsequent cytoskeleton redistribution and assembly in the process of migration. Additionally, RhoA and RhoC were involved in SDF-1-induced Jurkat cell migration. Taken together, we found a SDF-1/CXCR4-RhoA and RhoC-ROS-cytoskeleton pathway that regulates Jurkat cell migration in response to SDF-1. This work will contribute to a clearer insight into the migration mechanism of acute lymphoblastic leukemia.

Review: Factors affecting fouling in conventional pens for slaughter pigs

DEFF Research Database (Denmark)

Larsen, Mona Lilian Vestbjerg; Bertelsen, Maja; Pedersen, Lene Juul

2018-01-01

and pigs’ earlier experience. Further, these primary factors are affected by secondary factors such as the shape of the pen, the weight of the pigs and especially the heat balance of the pigs, which is affected by several tertiary factors including, for example, temperature, humidity and draught. Results...

Factors Affecting Prenatal Care Utilization in East Wollega Zone ...

African Journals Online (AJOL)

The objective of the study was to identify factors affecting utilization of prenatal care and skilled birth attendant in East Wollega zone. Prenatal care and skilled birth attendant are crucial factor which affects the health and wellbeing of the mother and newborn and help the women to access skilled assistance, drugs, ...

The quantum walk search algorithm: Factors affecting efficiency

OpenAIRE

Lovett, Neil B.; Everitt, Matthew; Heath, Robert M.; Kendon, Viv

2011-01-01

We numerically study the quantum walk search algorithm of Shenvi, Kempe and Whaley [PRA \\textbf{67} 052307] and the factors which affect its efficiency in finding an individual state from an unsorted set. Previous work has focused purely on the effects of the dimensionality of the dataset to be searched. Here, we consider the effects of interpolating between dimensions, connectivity of the dataset, and the possibility of disorder in the underlying substrate: all these factors affect the effic...

Determining the Factors Affecting Labor Productivity of Nurses

OpenAIRE

Yurdanur Dikmen; Dilek Kara Yilmaz; Handenur Basaran; Nasibe Yagmur Filiz

2016-01-01

Aim: This study was conducted to determine the factors affecting the labor productivity of nurses. Material and Methods: The study which was planned as descriptive and analytical was carried out with 156 nurses who volunteered to participate in the study in a public hospital in the northwest of Turkey. Data was collected with the and ldquo;Participant Presentation Form and rdquo; and the questionnaire including the factors affecting labor productivity which was developed by Ozkoc (2005). ...

Study of the factors affecting radon diffusion through building materials

International Nuclear Information System (INIS)

Chauhan, R.P.

2011-01-01

Radon appears mainly by diffusion processes from the point of origin following - decay of 226 Ra in underground soil and building materials used, in the construction of floors, walls, and ceilings. The diffusion of radon in dwellings is a process determined by the radon concentration gradient across the building material structure and can be a significant contributor to indoor radon inflow. Radon can originate from the deeply buried deposit beneath homes and can migrate to the surface of earth. Radon diffusion and transport through different media is a complex process and is affected by several factors. It is well known that for building construction materials the porosity, permeability and the diffusion coefficient are the parameters, which can quantify the materials capability to hinder the flow of radon soil gas. An increase in porosity will provide more air space within the material for radon to travel, thus reducing its resistance to radon transport. The permeability of material describes its ability to act as a barrier to gas movement when a pressure gradient exists across it and is closely related to the porosity of material. The radon diffusion coefficient of a material quantifies the ability of radon gas to move through it when a concentration gradient is the driving force. This parameter depends upon the porosity and permeability of the medium. As diffusion process is the major contributor to indoor levels, therefore, the factors affecting the diffusion process need to be kept in consideration. Keeping this in mind the experimental arrangements have been made for control study of radon diffusion through some building materials to observe the effects of different factors viz.; compaction, grain size, temperature, humidity and the mixing of these materials etc. For the present study alpha sensitive LR-115 type II solid-state nuclear track detectors (SSNTDs) have been used for the recording of alpha tracks caused by radon gas after its diffusion through the

Dispersal and migration

Directory of Open Access Journals (Sweden)

Schwarz, C.

2004-06-01

philopatric movement of geese using a classic multi–state design. Previous studies of philopaty often rely upon simple return rates —however, good mark–recapture studies do not need to assume equal detection probabilities in space and time. This is likely the most important contribution of multi–state modelling to the study of movement. As with many of these studies, the most pressing problem in the analysis is the explosion in the number of parameters and the need to choose parsimonious modelss to get good precision. Drake and Alisauska demonstrate that model choice still remains an art with a great deal of biological insight being very helpful in the task. There is still plenty of scope for novel methods to study migration. Traditionally, there has been a clear cut distinction between birds being labelled as “migrant” or “resident” on the basis of field observations and qualitative interpretations of patterns of ring–recoveries. However, there are intermediate species where only part of the population migrates (partial migrants or where different components of the population migrate to different extents (differential migrants. Siriwardena, Wernham and Baillie (Siriwardena et al., 2004 develop a novel method that produces a quantitative index of migratory tendency. The method uses distributions of ringing–to–recovery distances to classify individual species’ patterns of movement relative to those of other species. The areas between species’ cumulative distance distributions are used with multi–dimensional scaling to produce a similarity map among species. This map can be used to investigate the factors that affect the migratory strategies that species adopt, such as body size, territoriality and distribution, and in studies of their consequences for demographic parameters such as annual survival and the timing of breeding. The key assumption of the method is the similar recovery effort of species over space and time. It would be interesting to

Transforming Growth Factor β1 Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells Via Up-Regulation of Connective Tissue Growth Factor.

Science.gov (United States)

Liu, Haizhou; Wang, Shaoyang; Ma, Weimin; Lu, Youguang

2015-12-01

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with a poor patient survival. Expression of TGF-β1 is up-regulated in HCC and is thought to play a crucial role in the occurrence and development of HCC. However, the mechanism of TGF-β1-mediated facilitation of malignant growth and invasion remains unclear, although some previous studies highlighted a potential involvement of the connective tissue growth factor (CTGF). Here we demonstrate that the in vitro migration of the HCC cell line SMMC-7721 is increased in the presence of recombinant TGF-β1, and that this effect is reversed by the specific inhibitor SB431542. Furthermore, TGF-β1 treatment up-regulated the expression of its own mRNA as well as the expression of CTGF mRNA. The TGF-β1-stimulated migration of SMMC-7721 cells was diminished by siRNA silencing of CTGF. These in vitro observations were validated in a murine xenograft model. In particular, silencing of CTFG diminished the TGF-β1-induced tumorigenesis in experimental animals. In conclusion, TGF-β1 plays a critical role in HCC migration and invasion, and this effect is dependent on CTGF.

Modeling Bird Migration under Climate Change: A Mechanistic Approach

Science.gov (United States)

Smith, James A.

2009-01-01

How will migrating birds respond to changes in the environment under climate change? What are the implications for migratory success under the various accelerated climate change scenarios as forecast by the Intergovernmental Panel on Climate Change? How will reductions or increased variability in the number or quality of wetland stop-over sites affect migratory bird species? The answers to these questions have important ramifications for conservation biology and wildlife management. Here, we describe the use of continental scale simulation modeling to explore how spatio-temporal changes along migratory flyways affect en-route migration success. We use an individually based, biophysical, mechanistic, bird migration model to simulate the movement of shorebirds in North America as a tool to study how such factors as drought and wetland loss may impact migratory success and modify migration patterns. Our model is driven by remote sensing and climate data and incorporates important landscape variables. The energy budget components of the model include resting, foraging, and flight, but presently predation is ignored. Results/Conclusions We illustrate our model by studying the spring migration of sandpipers through the Great Plains to their Arctic breeding grounds. Why many species of shorebirds have shown significant declines remains a puzzle. Shorebirds are sensitive to stop-over quality and spacing because of their need for frequent refueling stops and their opportunistic feeding patterns. We predict bird "hydrographs that is, stop-over frequency with latitude, that are in agreement with the literature. Mean stop-over durations predicted from our model for nominal cases also are consistent with the limited, but available data. For the shorebird species simulated, our model predicts that shorebirds exhibit significant plasticity and are able to shift their migration patterns in response to changing drought conditions. However, the question remains as to whether this

Eastern migrations vs western welfare states - (unbiased fears

Directory of Open Access Journals (Sweden)

Josifidis Kosta

2013-01-01

Full Text Available This inquiry considers some effects of migration on the labour markets and the welfare systems found in the EU-15, and from the perspectives of sustainability of the current welfare state regimes. Our inquiry aims to determine whether and to what extent different approaches in regulation of migration flows between the new and old member states are compatible with related economic and demographic findings. Within this context, our research considers regulations affecting migration flows. Our findings suggest that some effects of migration from the EU8+2 on the labour markets and social protection systems found in the EU-15, both with respect to level and structure, do indeed generate effects on migration, especially considering whether migration is based upon economic or welfare decisions. In addition, our inquiry considers perspectives upon restrictive versus liberal migration policies.

Identifying factors affecting optimal management of agricultural water

Directory of Open Access Journals (Sweden)

Masoud Samian

2015-01-01

In addition to quantitative methodology such as descriptive statistics and factor analysis a qualitative methodology was employed for dynamic simulation among variables through Vensim software. In this study, the factor analysis technique was used through the Kaiser-Meyer-Olkin (KMO and Bartlett tests. From the results, four key elements were identified as factors affecting the optimal management of agricultural water in Hamedan area. These factors were institutional and legal factors, technical and knowledge factors, economic factors and social factors.

Labour migration and rural development in Egypt. A study of return migration in six villages.

Science.gov (United States)

Reichert, C

1993-01-01

An analysis of the impact of labor migration on social change in 6 rural villages (Shanawan and Kafr Shanawan north of Cairo, Kafr Yusuf and Tambul el Kubra near Simbalaween, and Abu Girg and Bani Walims in Minya governate) in Egypt was conducted in 1987-88. Since the 1991 Gulf war, the political environment, the labor markets, and the structure of migration opportunities have changed. An estimated 5% of rural households might have been directly affected by migrants' departure from Kuwait and Iraq. Data collection involved a household census survey of 8620 households, of which 2483 were migrants, including 1765 return migrants. A sample of return migrant (639) was interviewed about their migration experiences. Participant observation was also conducted among migrants and nonmigrants, and case studies were developed. Villages were demographically and socioeconomically very different; migration ranged from 18.5-434.2%. Structural change was measured on a scale of 1 to 6 in terms of population size, literacy of household heads, share of agricultural occupations, share of new red brick houses, and availability of infrastructural or institutional facilities. The probability of having a household with a migrant member increased with the rural character of the village. Landholdings or other major household variables were unrelated to migration. Rural outmigration was almost exclusively male, the average age was 29.6 years, and the average stay was 2.6 years. Migration destination was specific to individuals but affected by occupation and family or village resources. Professionals were overrepresented in Saudi Arabia, and farm and unskilled laborers or the unemployed were overrepresented in Iraq. Remittances from international migration have contributed along with the economic reforms of Sadat to new, private initiatives from all strata in rural society. 74.3% of returnees stated that improvement in income and living standards was the motivation for migration; many motives

Factors affecting the runoff response of watersheds to precipitation

OpenAIRE

DROZDOVÁ, Martina

2013-01-01

This bachelor thesis is focused on the factors that affect the drainage basin of the response. It contains a literature review, which deals with the hydrological cycle characteristics of precipitation, surface runoff and flood and erosion protection. The aim of the work is to evaluate the factors that adversely affect the runoff from the catchment.

Economic and Cultural Factors Affecting University Excellence

Science.gov (United States)

Jabnoun, Naceur

2009-01-01

Purpose: The ranking of top universities in the world has generated increased interest in the factors that enhance university performance. The purpose of this paper is to identify economic and cultural factors that affect the number of top ranking universities in each country. Design/methodology/approach: This paper first identifies the number of…

Effects of alluvial knickpoint migration on floodplain ecology and geomorphology

Science.gov (United States)

Larsen, Annegret; May, Jan-Hendrick

2016-04-01

Alluvial knickpoints are well described as erosional mechanism within discontinuous ephemeral streams in the semi-arid SW USA. However, alluvial knickpoints occur globally in a wide range of settings and of climate zones, including temperate SE Australia, subtropical Africa, and tropical Australia. Much attention has been given in the scientific literature to the trigger mechanisms of alluvial knickpoints, which can be summarized as: i) threshold phenomena, ii) climate variability and iii) land-use change, or to a combination of these factors. Recently, studies have focused on the timescale of alluvial knickpoint retreat, and the processes, mechanisms and feedbacks with ecology, geomorphology and hydrology. In this study, we compile data from a global literature review with a case study on a tropical river system in Australia affected by re-occurring, fast migrating (140 myr-1) alluvial knickpoint. We highlight the importance of potential water table declines due to channel incision following knickpoint migration, which in turn leads to the destabilization of river banks, and a shift in floodplain vegetation and fire incursion. We hypothesize that the observed feedbacks might also help to understand the broader impacts of alluvial knickpoint migration in other regions, and might explain the drastic effects of knickpoint migration on land cover and land-use in semi-arid areas.

Factors affecting the organization and management of emergency ...

African Journals Online (AJOL)

Factors affecting the organization and management of emergency mass casualty ... service all under a unified command of leadership with a specified job description. Factors identified were: Political will, human resource planning, appropriate ...

Factors affecting IUCD discontinuation in Nepal

DEFF Research Database (Denmark)

Thapa, Subash; Paudel, Ishwari Sharma; Bhattarai, Sailesh

2015-01-01

Information related to contraception discontinuation, especially in the context of Nepal is very limited. A nested case-control study was carried out to determine the factors affecting discontinuation of intrauterine contraceptive devices (IUCDs). A total of 115 cases (IUCD discontinuers) and 115...

Survival of migrating sea trout (Salmo trutta ) smolts during their passage of an artificial lake in a Danish lowland stream

DEFF Research Database (Denmark)

Schwinn, Michael; Aarestrup, Kim; Baktoft, Henrik

2017-01-01

Artificial lake development is often used as a management tool to reduce nutrient runoff to coastal waters. Denmark has restored more than 10 000 ha of wetlands and lakes in the last 14 years as a consequence of ‘Action Plans for the Aquatic Environment’, which aim to meet the demands...... of the European Union’s Water Framework Directive. Juvenile, seaward migrating salmonids are highly affected by impounded waterbodies, as they are subjected to extraordinary high mortalities due to predation and altered habitat. From 2005 to 2015, survival and migration patterns of wild brown trout (Salmo trutta....... Water temperature and discharge were key environmental factors affecting survival of the smolts during the passage of the lake. Furthermore, smolt survival was negatively correlated with condition factor. This elevated level of smolt mortality may seriously compromise self-sustaining anadromous salmonid...

Migration as a form of workforce attrition: a nine-country study of pharmacists.

Science.gov (United States)

Wuliji, Tana; Carter, Sarah; Bates, Ian

2009-04-09

There is a lack of evidence to inform policy development on the reasons why health professionals migrate. Few studies have sought to empirically determine factors influencing the intention to migrate and none have explored the relationship between factors. This paper reports on the first international attempt to investigate the migration intentions of pharmacy students and identify migration factors and their relationships. Responses were gathered from 791 final-year pharmacy students from nine countries: Australia, Bangladesh, Croatia, Egypt, Portugal, Nepal, Singapore, Slovenia and Zimbabwe. Data were analysed by means of Principal Components Analysis (PCA) and two-step cluster analysis to determine the relationships between factors influencing migration and the characteristics of subpopulations most likely and least likely to migrate. Results showed a significant difference in attitudes towards the professional and sociopolitical environment of the home country and perceptions of opportunities abroad between those who have no intention of migrating and those who intend to migrate on a long-term basis. Attitudes of students planning short-term migration were not significantly different from those of students who did not intend to migrate. These attitudes, together with gender, knowledge of other migrant pharmacists and past experiences abroad, are associated with an increased propensity for migration. Given the influence of the country context and environment on migration intentions, research and policy should frame the issue of migration in the context of the wider human resource agenda, thus viewing migration as one form of attrition and a symptom of other root causes. Remuneration is not an independent stand-alone factor influencing migration intentions and cannot be decoupled from professional development factors. Comprehensive human resource policy development that takes into account the issues of both remuneration and professional development are necessary

Unnoticed Ways in which Migration Reinforces Under development ...

African Journals Online (AJOL)

But this paper argues that there are unnoticed ways in which migration negatively affects development and low income economies. For this paper, the relationship between ... But to see that migration in turn reinforces underdevelopment, one needs to engage in some complex analysis. Alarmingly, the end-result of the ...

Effects of diel vertical migration on ephippia production in Daphnia

Directory of Open Access Journals (Sweden)

Victor ALEKSEEV

2004-09-01

Full Text Available Fish presence in experimentally simulated temperature conditions (limno-towers led to diel vertical migration and resulted in a decrease of ephippia production in Daphnia pulicaria. Diel fluctuation of food, temperature and day length similar to those experienced by migrating Daphnia were tested in laboratory experiments with flow-through-systems. Daphnids were kept under these conditions for 15 days and the proportions of females producing an ephippium were determined. In addition, maturation time, survival to maturation, size of the first clutch and female dry weight (without eggs on day 15 were traced. The most important factor affecting ephippia production in migrating Daphnia was photoperiod change, and when mother and embryo are exposed to alternating light conditions, these are thought to have the effect on the mother of acting as a signal to stop ephippia production. Such effects might be explained by the different sensitiveness to light intensity in females carrying an embryo and an embryo itself in broods. Fish presence forced Daphnia to stay in low-light conditions during daytime hours, to avoid attacks by fish. The Daphnia were able to check light intensity constantly by short vertical jumps above a light-threshold that was confirmed experimentally in limno-towers. The dim conditions were possibly light enough for adults to check day length, but were too dark for embryos shaded by the mother's body. Food conditions played a relatively small role in the process, and no effects of temperature on ephippia production were found. As expected, food affected the size of the first clutch, and temperature controlled the time to maturation. Photoperiod had a marginally significant influence on the time to maturation in Daphnia. A hypothesis on the role of photoperiod as the key factor for Daphnia life cyclic recurrence and other seasonal adaptations is proposed.

Factors affecting the design of instrument flight procedures

Directory of Open Access Journals (Sweden)

Ivan FERENCZ

2008-01-01

Full Text Available The article highlights factors, which might affect the design of instrument flight procedures. Ishikawa diagram is used to distribute individual factors into classes, as are People, Methods, Regulations, Tools, Data and Environment.

DEFINING HUMAN MIGRATION – A POLICY MAKERS PERSPECTIVE

Directory of Open Access Journals (Sweden)

Paul-Panfil IVAN

2015-06-01

Full Text Available Migration is a global phenomenon gradually increased in scope, impact and complexity. Practically all countries are simultaneously countries of destination, origin and transit for migrants. Traditionally migration flows are complemented by new changes generated by economic, demographic, political or social conditions, and these trends affect both the size and structure of the migrant population and also economies and societies. Of course this has sparked international interest from various NGOs and by the European Union and the United Nations. This paper aims to present the vision of international organizations concerned with migration and how they define migration and its typologies.

Factors Affecting Rural Facilitators’ Role: Iran

OpenAIRE

Azimi, Farideh; Kamali, Mohammad Bagher

2011-01-01

This study aimed to examine key factors affecting rural female facilitators’ role in participatory rural development in Tehran Province. Since the researchers intended to have a better insight into the facilitators’ role and employ inquiry as a learning forum for bringing about changes for all participants, they preferred to use a case study based upon an appreciative inquiry method. The study divided the factors affecting the facilitators’ role into two main categories: driving factors...

Psychological factors affecting equine performance

Directory of Open Access Journals (Sweden)

McBride Sebastian D

2012-09-01

Full Text Available Abstract For optimal individual performance within any equestrian discipline horses must be in peak physical condition and have the correct psychological state. This review discusses the psychological factors that affect the performance of the horse and, in turn, identifies areas within the competition horse industry where current behavioral research and established behavioral modification techniques could be applied to further enhance the performance of animals. In particular, the role of affective processes underpinning temperament, mood and emotional reaction in determining discipline-specific performance is discussed. A comparison is then made between the training and the competition environment and the review completes with a discussion on how behavioral modification techniques and general husbandry can be used advantageously from a performance perspective.

Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses.

Science.gov (United States)

Twu, Olivia; Dessí, Daniele; Vu, Anh; Mercer, Frances; Stevens, Grant C; de Miguel, Natalia; Rappelli, Paola; Cocco, Anna Rita; Clubb, Robert T; Fiori, Pier Luigi; Johnson, Patricia J

2014-06-03

The human-infective parasite Trichomonas vaginalis causes the most prevalent nonviral sexually transmitted infection worldwide. Infections in men may result in colonization of the prostate and are correlated with increased risk of aggressive prostate cancer. We have found that T. vaginalis secretes a protein, T. vaginalis macrophage migration inhibitory factor (TvMIF), that is 47% similar to human macrophage migration inhibitory factor (HuMIF), a proinflammatory cytokine. Because HuMIF is reported to be elevated in prostate cancer and inflammation plays an important role in the initiation and progression of cancers, we have explored a role for TvMIF in prostate cancer. Here, we show that TvMIF has tautomerase activity, inhibits macrophage migration, and is proinflammatory. We also demonstrate that TvMIF binds the human CD74 MIF receptor with high affinity, comparable to that of HuMIF, which triggers activation of ERK, Akt, and Bcl-2-associated death promoter phosphorylation at a physiologically relevant concentration (1 ng/mL, 80 pM). TvMIF increases the in vitro growth and invasion through Matrigel of benign and prostate cancer cells. Sera from patients infected with T. vaginalis are reactive to TvMIF, especially in males. The presence of anti-TvMIF antibodies indicates that TvMIF is released by the parasite and elicits host immune responses during infection. Together, these data indicate that chronic T. vaginalis infections may result in TvMIF-driven inflammation and cell proliferation, thus triggering pathways that contribute to the promotion and progression of prostate cancer.

Macrophage migration inhibitory factor deficiency is associated with impaired killing of gram-negative bacteria by macrophages and increased susceptibility to Klebsiella pneumoniae sepsis.

Science.gov (United States)

Roger, Thierry; Delaloye, Julie; Chanson, Anne-Laure; Giddey, Marlyse; Le Roy, Didier; Calandra, Thierry

2013-01-15

The cytokine macrophage migration inhibitory factor (MIF) is an important component of the early proinflammatory response of the innate immune system. However, the antimicrobial defense mechanisms mediated by MIF remain fairly mysterious. In the present study, we examined whether MIF controls bacterial uptake and clearance by professional phagocytes, using wild-type and MIF-deficient macrophages. MIF deficiency did not affect bacterial phagocytosis, but it strongly impaired the killing of gram-negative bacteria by macrophages and host defenses against gram-negative bacterial infection, as shown by increased mortality in a Klebsiella pneumonia model. Consistent with MIF's regulatory role of Toll-like 4 expression in macrophages, MIF-deficient cells stimulated with lipopolysaccharide or Escherichia coli exhibited reduced nuclear factor κB activity and tumor necrosis factor (TNF) production. Addition of recombinant MIF or TNF corrected the killing defect of MIF-deficient macrophages. Together, these data show that MIF is a key mediator of host responses against gram-negative bacteria, acting in part via a modulation of bacterial killing by macrophages.

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration

Science.gov (United States)

Marei, Hadir; Carpy, Alejandro; Woroniuk, Anna; Vennin, Claire; White, Gavin; Timpson, Paul; Macek, Boris; Malliri, Angeliki

2016-01-01

The small GTPase Rac1 has been implicated in the formation and dissemination of tumours. Upon activation by guanine nucleotide exchange factors (GEFs), Rac1 associates with a variety of proteins in the cell thereby regulating various functions, including cell migration. However, activation of Rac1 can lead to opposing migratory phenotypes raising the possibility of exacerbating tumour progression when targeting Rac1 in a clinical setting. This calls for the identification of factors that influence Rac1-driven cell motility. Here we show that Tiam1 and P-Rex1, two Rac GEFs, promote Rac1 anti- and pro-migratory signalling cascades, respectively, through regulating the Rac1 interactome. In particular, we demonstrate that P-Rex1 stimulates migration through enhancing the interaction between Rac1 and the actin-remodelling protein flightless-1 homologue, to modulate cell contraction in a RhoA-ROCK-independent manner. PMID:26887924

Workplace, Biographical and Motivation Factors Affecting ...

African Journals Online (AJOL)

This paper presents the findings of a survey on how workplace, biographical and motivational factors affect the organisational commitment of records officers in federal universities in Nigeria. Single stage random sampling, with equal allocation method, was used to administer questionnaire on 300 sampled participants from ...

On the interrelations between migration and commuting

Directory of Open Access Journals (Sweden)

Lukić Vesna

2013-01-01

Full Text Available In this paper, we emphasise the significance of studying the interrelations between commuting and migration. The aim of the paper is to point out the factors which affect these interrelations (demographic and socio-economic characteristics of migrants and commuters, labour market, real estate market, information, life style, etc., with the special emphasis on the role of commuting distance onto the chosen mobility type. Besides theorethical frameworks and results of the selected foreign researches up to date, the overview of research of interrelations between migration and commuting in Serbia has also been presented. While earlier studies conducted by Gawryszenski (1978, Termote (1980 and Reitsma&Vergoossen (1987 pointed to the replacement of migration types between each other within country, in recent literature the interaction between migration and commuting has been studied in a trans-boundary context of the contemporary EU. Modern trend of long distance commuting instead of migration and the concept of substitution/replacement regarding migration and commuting have also been discussed. In Serbia, there is a positive correlation between commuting outflows and immigration in rural settlements of Vojvodina province. Namely, commuting and migration are complement, which is the characteristic of both processes sub-urbanisation and ex-urbanisation (Lukić, 2012. In addition to ownership of real estate and previous migration experience, marital status influenced the chosen mobility type in Serbia as well. Adjustment to changes of Serbian labour market is mostly conducted via migration (Miletić, Lukić, Miljanović, 2011. Interrelations between migration and commuting are very significant due to the tendency of transformation of some commuters into migrants. This process has its consequences, both on demographic as well as the overall socio-economic development of the area of commuters’ origin and destination. However, even though the surveys

Population, migration and urbanization.

Science.gov (United States)

1982-06-01

in rural areas. According to UN data, at the global level the trend in longterm and permanent migration is towards stabilization or decline in the rate of movement into developed countries like the US, Canada, the UK, and Australia from developing countries. Migrants in the Asian and Pacific region mostly tend to be in the 15-25 year age group. Most migrants streams are male dominant. The rural urban migration stream includes a large proportion of people who are better educated than their rural counterparts but generally less educated than the urban natives. Reasons for migrating in the Asian and Pacific region are economic, educational, sociocultural and political. A negative factor in rural migration is that it deprives villages of the ablest people.

Psychological factors affecting equine performance

OpenAIRE

McBride, Sebastian D; Mills, Daniel S

2012-01-01

Abstract For optimal individual performance within any equestrian discipline horses must be in peak physical condition and have the correct psychological state. This review discusses the psychological factors that affect the performance of the horse and, in turn, identifies areas within the competition horse industry where current behavioral research and established behavioral modification techniques could be applied to further enhance the performance of animals. In particular, the role of af...

Stopover habitats of spring migrating surf scoters in southeast Alaska

Science.gov (United States)

Lok, E.K.; Esler, Daniel; Takekawa, John Y.; De La Cruz, S.W.; Sean, Boyd W.; Nysewander, D.R.; Evenson, J.R.; Ward, D.H.

2011-01-01

Habitat conditions and nutrient reserve levels during spring migration have been suggested as important factors affecting population declines in waterfowl, emphasizing the need to identify key sites used during spring and understand habitat features and resource availability at stopover sites. We used satellite telemetry to identify stopover sites used by surf scoters migrating through southeast Alaska during spring. We then contrasted habitat features of these sites to those of random sites to determine habitat attributes corresponding to use by migrating scoters. We identified 14 stopover sites based on use by satellite tagged surf scoters from several wintering sites. We identified Lynn Canal as a particularly important stopover site for surf scoters originating throughout the Pacific winter range; approximately half of tagged coastally migrating surf scoters used this site, many for extended periods. Stopover sites were farther from the mainland coast and closer to herring spawn sites than random sites, whereas physical shoreline habitat attributes were generally poor predictors of site use. The geography and resource availability within southeast Alaska provides unique and potentially critical stopover habitat for spring migrating surf scoters. Our work identifies specific sites and habitat resources that deserve conservation and management consideration. Aggregations of birds are vulnerable to human activity impacts such as contaminant spills and resource management decisions. This information is of value to agencies and organizations responsible for emergency response planning, herring fisheries management, and bird and ecosystem conservation. Copyright ?? 2011 The Wildlife Society.

Physical factors affecting the electrically assisted thermal bitumen recovery

Energy Technology Data Exchange (ETDEWEB)

Bogdanov, I.I.; Torres, J.-A.; Kamp, A.M. [CHLOE, University of Pau (France); Corre, B. [CSTJF, Total (France)

2011-07-01

In the heavy oil industry, thermal processes are used to enhance oil recovery by increasing the reservoir temperature which results in better oil mobility. Low frequency heating (LFH) is a technology using electrical conductivity of connate water to propagate current between electrodes, thus generating heat in the reservoir through the Joule effect. During the preheating and production periods, many physical factors may affect the LFH process and the aim of this study was to determine which factors affect the process and how, using a particular pattern of electrodes. Simulations were conducted using the CMG Stars reservoir simulator under different configurations, conditions and parameters. Important physical properties and operational conditions affecting the LFH process were determined and results showed that convection heat, bulk electrical conductivity and power distribution can be improved by salt water circulation. This paper highlighted the physical factors affecting LFH efficiency and these findings will be useful for future process design.

Sex biased survival and differences in migration of wild steelhead (Oncorhynchus mykiss) smolts from two coastal Oregon rivers

Science.gov (United States)

Thompson, Neil F.; Leblanc, Camille A.; Romer, Jeremy D.; Schreck, Carl B.; Blouin, Michael S.; Noakes, David L. G.

2016-01-01

In salmonids with partial migration, females are more likely than males to undergo smoltification and migrate to the ocean (vs. maturing in freshwater). However, it is not known whether sex affects survivorship during smolt migration (from fresh water to entry into the ocean). We captured wild steelhead (Oncorhynchus mykiss) smolts in two coastal Oregon rivers (USA) and collected fin tissue samples for genetic sex determination (2009; N = 70 in the Alsea and N = 69 in the Nehalem, 2010; N = 25 in the Alsea). We implanted acoustic tags and monitored downstream migration and survival until entry in to the Pacific Ocean. Survival was defined as detection at an estuary/ocean transition array. We found no effect of sex on smolt survivorship in the Nehalem River in 2009, or in the Alsea River in 2010. However, males exhibited significantly lower survival than females in the Alsea River during 2009. Residency did not influence this result as an equal proportion of males and females did not reach the estuary entrance (11% of males, 9% of females). The sexes did not differ in timing or duration of migration, so those variables seem unlikely to explain sex-biased survivorship. Larger males had higher odds of survival than smaller males in 2009, but the body size of females did not affect survivorship. The difference in survivorship between years in the Alsea River could be due to flow conditions, which were higher in 2010 than in 2009. Our findings suggest that sex may affect steelhead smolt survival during migration, but that the difference in survivorship may be weak and not a strong factor influencing adult sex ratios.

Sex-biased survivorship and differences in migration of wild steelhead (Oncorhynchus mykiss) smolts from two coastal Oregon rivers

Science.gov (United States)

Thompson, Neil F.; Leblanc, Camille A.; Romer, Jeremy D.; Schreck, Carl B.; Blouin, Michael S.; Noakes, David L. G.

2016-01-01

In salmonids with partial migration, females are more likely than males to undergo smoltification and migrate to the ocean (vs. maturing in freshwater). However, it is not known whether sex affects survivorship during smolt migration (from fresh water to entry into the ocean). We captured wild steelhead (Oncorhynchus mykiss) smolts in two coastal Oregon rivers (USA) and collected fin tissue samples for genetic sex determination (2009; N = 70 in the Alsea and N = 69 in the Nehalem, 2010; N = 25 in the Alsea). We implanted acoustic tags and monitored downstream migration and survival until entry in to the Pacific Ocean. Survival was defined as detection at an estuary/ocean transition array. We found no effect of sex on smolt survivorship in the Nehalem River in 2009, or in the Alsea River in 2010. However, males exhibited significantly lower survival than females in the Alsea River during 2009. Residency did not influence this result as an equal proportion of males and females did not reach the estuary entrance (11% of males, 9% of females). The sexes did not differ in timing or duration of migration, so those variables seem unlikely to explain sex-biased survivorship. Larger males had higher odds of survival than smaller males in 2009, but the body size of females did not affect survivorship. The difference in survivorship between years in the Alsea River could be due to flow conditions, which were higher in 2010 than in 2009. Our findings suggest that sex may affect steelhead smolt survival during migration, but that the difference in survivorship may be weak and not a strong factor influencing adult sex ratios.

A STUDY ON THE INTERNAL MIGRATION FLOWS IN TURKEY: LOWRY HYPOTHESIS

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FERHAT TOPBAŞ

2013-06-01

Full Text Available The purpose of this study is to re-examine Lowry hypothesis that were examined for Turkey in period of 1965–1980 by Gedik (1992 and period of 1985–1990 by Yamak and Küçükkale (2001 by using The Census of Population 1975, 1980, 1985, 1990 and 2000 in Turkey. For this reason, the relationships between in-migration and out-migration and net migration have investigated with population size, net migration rate and per capita income factors. Analysis that involve in all provinces called general model is not considered in social, economic and urban development factors. In addition, estimated restriction models that are considered urban development are involved population, net migration rate and per capita income factors. In conclusion we have exposed comparatively relationship between internal migration flows and urban development frame of estimated models.

Migration processes in SCO member states

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Valentina Sergeevna Antonyuk

2012-12-01

Full Text Available The article concerns modern state and development of migration processes in SCO member states. As a main method of research statistical analysis was applied. The article shows that migration streams between SCO member states are rather intensive, and the problem of labor migration becomes more and more urgent. The countries of consuming and supplying of labour force are clearly differentiated in the region. For some countries, labor export is the key sector of economy. At the same time, interstate relations between SCO member states sometimes are rather disputed. The most urgent factors causing the development of migration processes in the region were determined. Among them, thefactor of growing outflows from China isespecially noted. It is noted that migration processes are discussed by SCO member states nowadays in terms of illegal migration and international criminality connected with it. It means that the question of labor migration is a real problem. It is indicated that the creation of a specific joint commission on migration policy affiliated with the Council of Foreign Ministers of SCO member states is the necessary condition of effective interaction in migration questions within the framework of Shanghai Cooperation Organization.

Political freedom and the response to economic incentives: labor migration in Africa, 1972-1987.

Science.gov (United States)

Barkley, A P; Mcmillan, J

1994-12-01

This study examines the thesis that political institutions and the freedoms and civil rights generated by these institutions affect migration decisions. The hypothesis is based on one stated by Adam Smith in 1776, that economic conditions that reflect greater political freedoms and civil liberties harbor higher levels of resource mobility in response to economic incentives. Pooled cross-sectional and time-series analysis is based on data from the World Bank for 32 African countries during 1972-87. Findings support the hypothesis that migration rate is more affected by the expected returns ratio to labor in countries where civil liberties are greater than in nations with fewer civil liberties. The implication, from the inclusion of institutional factors in the model, is that civil liberties have an indirect impact on the rate of labor migration out of agriculture in Africa. The impact is a mix of economic incentives and civil liberties. In the political rights model, the most free countries had the largest migration elasticity. The findings on political rights impacts support findings by Friedman and McMillan that civil liberties are a more important determinant of economic growth than political rights. Further testing for measurement error confirmed that the data were flawed, but not so greatly that the basic findings were overturned. The migration out of African agriculture was found to be sensitive to the effect of price signals, which were conditioned by the degree of political rights and civil liberties. Policy makers are urged to consider both changes in pricing and institutions.

Investigation of Factors Affecting Microdialysis Probe Delivery and ...

African Journals Online (AJOL)

HP

Purpose: To investigate in vitro the factors affecting microdialysis probe delivery and recovery of puerarin . Methods: ... methods. Factors such as drug concentration, stirring speed, additives and length of membrane were ... The high performance liquid chromatography ..... Pharmacokinetic Modeling to Investigate Regional.

Personality factors and adult attachment affecting job mobility

NARCIS (Netherlands)

van Vianen, A.E.M.; Feij, J.A.; Krausz, M.; Taris, R.

2003-01-01

Past research has revealed that individuals' job mobility is affected by factors such as job satisfaction, specific career enhancing attributes and job availability. This study examined personality factors predicting voluntary internal and external job mobility. Three types of voluntary job mobility

Isotope migration and barrier in a VLLW site

International Nuclear Information System (INIS)

Kang Houjun; Zhang Dong; Yang Yong; Shi Zhengkun; Li Kuanliang; Zhang Peicong

2010-01-01

In this work, adsorption and migration of 238 U and 90 Sr in unsaturated soil at a VLLW (very low level waste) site was investigated, in an attempt to find geochemical features of the site. Migration of the isotopes in heterosphere was studied under instantaneous and sequential conditions of the sources. The migration barrier experiment was carried out in two steps on wall rock absorption of the isotopes and addictives to improve the barrier of the wall rock to 90 Sr. The results show that the migration speed of 238 U and 90 Sr in the soil is 0.365 and 0.385 mm/a, respectively. The heterosphere effects on the isotope migration not only alleviated the mainstream contamination, but also prolonged the time of contaminated affection. And false zeolite should be used as barrier additive material for 90 Sr migration. (authors)

Parallel factor analysis PARAFAC of process affected water

Energy Technology Data Exchange (ETDEWEB)

Ewanchuk, A.M.; Ulrich, A.C.; Sego, D. [Alberta Univ., Edmonton, AB (Canada). Dept. of Civil and Environmental Engineering; Alostaz, M. [Thurber Engineering Ltd., Calgary, AB (Canada)

2010-07-01

A parallel factor analysis (PARAFAC) of oil sands process-affected water was presented. Naphthenic acids (NA) are traditionally described as monobasic carboxylic acids. Research has indicated that oil sands NA do not fit classical definitions of NA. Oil sands organic acids have toxic and corrosive properties. When analyzed by fluorescence technology, oil sands process-affected water displays a characteristic peak at 290 nm excitation and approximately 346 nm emission. In this study, a parallel factor analysis (PARAFAC) was used to decompose process-affected water multi-way data into components representing analytes, chemical compounds, and groups of compounds. Water samples from various oil sands operations were analyzed in order to obtain EEMs. The EEMs were then arranged into a large matrix in decreasing process-affected water content for PARAFAC. Data were divided into 5 components. A comparison with commercially prepared NA samples suggested that oil sands NA is fundamentally different. Further research is needed to determine what each of the 5 components represent. tabs., figs.

Factors affecting the performance of professional nurses in Namibia

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Magdalene H. Awases

2013-04-01

Objectives: The aim of the present study was to identify factors affecting the performance of professional nurses in Namibia. Method: A quantitative, descriptive survey was used to collect data by means of a questionnaire. A random sample of 180 professional nurses was selected from six hospitals in three regions of Namibia. Results: Factors affecting the performance of nurses negatively were identified such as: lack of recognition of employees who are performing well, quality performance outcomes and an absence of a formal performance appraisal system and poor working conditions. Various factors contribute to both the positive and negative performance of professional nurses in Namibia. Strategies were developed for addressing the negative factors that could positively affect the performance of professional nurses in Namibia. Conclusions: This study emphasises the importance of developing strategies to promote the performance of nurses; build knowledge and expertise; develop mechanisms for improving the performance of nurses; expand leadership and management capacity; and generate information and knowledge through research.

Economic and geographic factors affecting the development of Greater Baku

Directory of Open Access Journals (Sweden)

Vusat AFANDIYEV

2014-12-01

Full Text Available Globally, the responsible factors for the ongoing development of urbanization are the high speed of population growth, and the mass migration of humans to cities and large urban areas. In most countries, this process resulted in the emergence of ‘pseudo-urbanization’ which is difficult to be regulated. The purpose of the carried researches to determine the development priorities in the territory of Greater Baku – the capital city of the Republic of Azerbaijan; to define the problems that take place in this connection; and to develop ways of elimination of these problems. The reason of taking Baku as a research area is connected with some of the factors. Firstly, studies on Baku have been conducted based on the Soviet geographical and urban planning school and their methods for a long period. In this regard, it is necessary to carry out research in this field based on the principles adopted in most countries. Secondly, since 1992, the intensive accumulation of population in the territory of the capital city and the surrounding areas is being observed because of socio-economic problems. As a result, the process of pseudo-urbanization intensified, entailing a densely-populated area. Thirdly, low-rise buildings still continue to exist in the large areas within the territory of Baku, and they are not associated with the functional structure of the city. This situation creates many challenges, particularly in terms of density growth and effective use of the city’s territory. Finally, numerous new buildings have been constructed in the residential areas of Baku in recent years, and this may entailserious problems in water supply, energy provision, and utilities. The study is carried out referring to previous works of researchers, statistic data, and the results of the population census conducted in 1959-2009.The practical significance of the scientific work is that positive and negative factors affecting the further development of Greater Baku

Self-selection and intermunicipal migration in Canada.

Science.gov (United States)

Islam, M N; Choudhury, S A

1991-02-01

"This paper investigates individual intermunicipal migration behaviour in Canada within the context of a human capital model that adjusts for the migrant's selectivity in computing expected income gains. In addition to the typical regional determinants of migration, housing and labour market characteristics are found to influence intermunicipal migration significantly, the effects differing with age. Structural coefficients remained more or less stable during the decade 1971-1981. It is shown that the failure to adjust income gains for selectivity bias results in an underestimation of the migration-impacts of income gains and municipal-specific factors." excerpt

Common and Specific Features of Migration Flows In Russia, CIS and Far Abroad

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Tamara Vladimirovna Kuprina

2015-06-01

Full Text Available The article discusses the features of migration flows in Russia, CIS and abroad in terms of transnationality and translocality. Special attention is paid to migration flows from Asia, depending on the gender perception. During the analysis, the preferences of migrants of different age groups are determined. It shows their desire for a more independent financial and professional life, relationship with family responsibilities, plans for the future. The data obtained by the method of continuous selection have led to the following conclusions: migration is a multidimensional phenomenon that requires multidisciplinary research; the heterogeneity of migration flows to the socio-cultural and gender features must be taken into account; the problem of illegal migration requires special solutions; in connection with the emigration of highly skilled professionals and immigration of low-skilled personnel, a professional important indicator of migratory replacement and attracting compatriots from abroad are important. The data obtained can be used for ethnic and cultural planning in order to improve production activities that affect the quality of solving of production tasks and programming adaptation of migrants as the significant impact of intangible factors on the development of society has been noted by economists for a long time. Thus, the economic sustainability requires new thinking based on socio-cultural sustainability determined by such global phenomena as international migration flows.

Private primary care physicians' perspectives on factors affecting the adoption of electronic medical records: a qualitative pre-implementation study.

Science.gov (United States)

Or, Calvin; Wong, Katie; Tong, Ellen; Sek, Antonio

2014-01-01

Use of electronic medical records (EMR) has the potential to offer quality and safety benefits, but without the adoption of the technology, the benefits will not be realized. This study aimed to identify the factors perceived as relevant by private physicians when considering EMR adoption. A qualitative pre-implementation study was conducted using semi-structured, face to face interviews to explore the perspectives of physicians (n=16) operating in private clinics on the factors affecting their adoption of EMR. A multilevel, work system approach and the immersion/crystallization data analysis technique guided the researchers in examining the data, identifying patterns and key themes, and extracting representative quotes to illustrate these themes. The major factors associated with EMR adoption, which relate to the five categories of a work system, were system usefulness; user interface design; technical support; cost; system reliability; the privacy, confidentiality, and security of patient information; physical space in the clinic; data migration process; adverse work-related factors; and the computer and systems skills of physicians. Pre-implementation identification of factors important to adoption can allow system developers to focus proactively on these factors when developing the system and its implementation strategies, to maximize the likelihood of successful introduction.

Migration and speciation of heavy metal in salinized mine tailings affected by iron mining.

Science.gov (United States)

Zhang, Xu; Yang, Huanhuan; Cui, Zhaojie

2017-10-01

The negative effects of heavy metals have aroused much attention due to their high toxicity to human beings. Migration and transformation trend of heavy metals have a close relationship with soil safety. Researching on migration and transformation of heavy metals in tailings can provide a reliable basis for pollution management and ecosystem restoration. Heavy metal speciation plays an important role in risk assessment. We chose Anshan tailings for our study, including field investigations and laboratory research. Four typical heavy metal elements of mine tailings {Fe (373.89 g/kg), Mn (2,303.80 mg/kg), Pb (40.99 mg/kg) and Cr (199.92 mg/kg)} were studied via Tessier test in vertical and horizontal direction. The main speciation of heavy metals in Anshan tailings was the residual. However, heavy metals have a strong ability for migration and transformation in vertical and horizontal directions. Its tendency to change from stable to unstable speciation results in increasing bioavailability and potential bioavailability. Fe, Mn, Pb and Cr showed different ability in the migration and transformation process (Mn > Pb > Fe > Cr) depending on the characteristics of heavy metals and physicochemical properties of the environment.

Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population

NARCIS (Netherlands)

Bossini-Castillo, L.; Simeon, C.P.; Beretta, L.; Vonk, M.C.; Callejas-Rubio, J.L.; Espinosa, G.; Carreira, P.; Camps, M.T.; Rodriguez-Rodriguez, L.; Rodriguez-Carballeira, M.; Garcia-Hernandez, F.J.; Lopez-Longo, F.J.; Hernandez-Hernandez, V.; Saez-Comet, L.; Egurbide, M.V.; Hesselstrand, R.; Nordin, A.; Hoffmann-Vold, A.M.; Vanthuyne, M.; Smith, V.; Langhe, E. De; Kreuter, A.; Riemekasten, G.; Witte, T.J.M. de; Hunzelmann, N.; Voskuyl, A.E.; Schuerwegh, A.J.; Lunardi, C.; Airo, P.; Scorza, R.; Shiels, P.; Laar, J.M. van; Fonseca, C.; Denton, C.; Herrick, A.; Worthington, J.; Koeleman, B.P.; Rueda, B.; Radstake, T.R.D.J.; Martin, J.

2011-01-01

Objectives. The aim of this study was to confirm the implication of macrophage migration inhibitory factor (MIF) gene in SSc susceptibility or clinical phenotypes in a large European population. Methods. A total of 3800 SSc patients and 4282 healthy controls of white Caucasian ancestry from eight

Contemporary world migration - towards new terminology, patterns and policies

Directory of Open Access Journals (Sweden)

Šantić Danica

2016-01-01

Full Text Available In the last decades, after the Cold War and the fall of the Berlin wall, the strengthening of overall population mobility is evident on local, regional, national and global scale. In addition, there are changes in the scope and direction of migration, their structural characteristics and increasing in the number of determining factors and consequences, which affects the complexity of this phenomenon. It is important to point out the emergence of new forms of migration as a result of intensifying pace of globalization, which is an integral part of the migration. The total number of migrants in the world (internal and external in the first decade of the XXI century reached the highest value in history and is around one billion, with small, but continuous increase in share of total population. This means that one in every seven person in the world has changed place of residence, either within their own country (about 700 million of internal migrants or moved to another country (244 million international migrants. Therefore some authors points out that all of us are becoming migrants. Also, the number of irregular migrants recently has reached its highest amount, which implies an intensification of government actions to regulate migration through the creation of effective policies, spatial mobility and intensification of bilateral, regional and international negotiations in this domain. Estimates show that the number of migrants will continue to grow, especially the number of climate migrants, persons who left their homes due to changes in the environment. That is why it is of crucial importance in a first place to understand migrations properly and then to create the steps towards the best solutions in solving the problems caused by population movement in space and create proper migration policies.

Macrophage Migration Inhibitory Factor: Critical Role in Obesity, Insulin Resistance, and Associated Comorbidities

Directory of Open Access Journals (Sweden)

Robert Kleemann

2010-01-01

Full Text Available Obesity is associated with insulin resistance, disturbed glucose homeostasis, low grade inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease. The cytokine macrophage migration inhibitory factor (MIF is an ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. This is a comprehensive summary of our current knowledge on the role of MIF in obesity and obesity-associated comorbidities, based on human clinical data as well as animal models of disease.

Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection

DEFF Research Database (Denmark)

Ostergaard, Christian; Benfield, Thomas

2009-01-01

ABSTRACT: INTRODUCTION: Macrophage Migration Inhibitory Factor (MIF) plays an essential pathophysiological role in septic shock; however, its role in central nervous system infection (CNS) remains to be defined. METHODS: The aim of the present study was to investigate cerebrospinal fluid (CSF......-22725) vs. 3240ng/L (1563-9302), respectively, P=0.003), and in patients with impaired consciousness (8614 ng/L (3344-20935) vs. 2625 ng/L (1561-7530), respectively, P=0.02). CSF MIF levels correlated significantly to the meningeal inflammation (Psystemic inflammatory response (P>0...

A space oddity: geographic and specific modulation of migration in Eudyptes penguins.

Science.gov (United States)

Thiebot, Jean-Baptiste; Cherel, Yves; Crawford, Robert J M; Makhado, Azwianewi B; Trathan, Philip N; Pinaud, David; Bost, Charles-André

2013-01-01

Post-breeding migration in land-based marine animals is thought to offset seasonal deterioration in foraging or other important environmental conditions at the breeding site. However the inter-breeding distribution of such animals may reflect not only their optimal habitat, but more subtle influences on an individual's migration path, including such factors as the intrinsic influence of each locality's paleoenvironment, thereby influencing animals' wintering distribution. In this study we investigated the influence of the regional marine environment on the migration patterns of a poorly known, but important seabird group. We studied the inter-breeding migration patterns in three species of Eudyptes penguins (E. chrysolophus, E. filholi and E. moseleyi), the main marine prey consumers amongst the World's seabirds. Using ultra-miniaturized logging devices (light-based geolocators) and satellite tags, we tracked 87 migrating individuals originating from 4 sites in the southern Indian Ocean (Marion, Crozet, Kerguelen and Amsterdam Islands) and modelled their wintering habitat using the MADIFA niche modelling technique. For each site, sympatric species followed a similar compass bearing during migration with consistent species-specific latitudinal shifts. Within each species, individuals breeding on different islands showed contrasting migration patterns but similar winter habitat preferences driven by sea-surface temperatures. Our results show that inter-breeding migration patterns in sibling penguin species depend primarily on the site of origin and secondly on the species. Such site-specific migration bearings, together with similar wintering habitat used by parapatrics, support the hypothesis that migration behaviour is affected by the intrinsic characteristics of each site. The paleo-oceanographic conditions (primarily, sea-surface temperatures) when the populations first colonized each of these sites may have been an important determinant of subsequent migration

A space oddity: geographic and specific modulation of migration in Eudyptes penguins.

Directory of Open Access Journals (Sweden)

Jean-Baptiste Thiebot

Full Text Available Post-breeding migration in land-based marine animals is thought to offset seasonal deterioration in foraging or other important environmental conditions at the breeding site. However the inter-breeding distribution of such animals may reflect not only their optimal habitat, but more subtle influences on an individual's migration path, including such factors as the intrinsic influence of each locality's paleoenvironment, thereby influencing animals' wintering distribution. In this study we investigated the influence of the regional marine environment on the migration patterns of a poorly known, but important seabird group. We studied the inter-breeding migration patterns in three species of Eudyptes penguins (E. chrysolophus, E. filholi and E. moseleyi, the main marine prey consumers amongst the World's seabirds. Using ultra-miniaturized logging devices (light-based geolocators and satellite tags, we tracked 87 migrating individuals originating from 4 sites in the southern Indian Ocean (Marion, Crozet, Kerguelen and Amsterdam Islands and modelled their wintering habitat using the MADIFA niche modelling technique. For each site, sympatric species followed a similar compass bearing during migration with consistent species-specific latitudinal shifts. Within each species, individuals breeding on different islands showed contrasting migration patterns but similar winter habitat preferences driven by sea-surface temperatures. Our results show that inter-breeding migration patterns in sibling penguin species depend primarily on the site of origin and secondly on the species. Such site-specific migration bearings, together with similar wintering habitat used by parapatrics, support the hypothesis that migration behaviour is affected by the intrinsic characteristics of each site. The paleo-oceanographic conditions (primarily, sea-surface temperatures when the populations first colonized each of these sites may have been an important determinant of

A Study of Factors Affecting the Renewal of Health Insurance Policy

OpenAIRE

Bhat Ramesh; Jain Nishant

2007-01-01

Health insurance policies are generally one-year policies and to remain part of the insurance poll, policyholders are required to renew their policies each year. Understanding the factors that affect the demand and renewal decisions to continue in health insurance programme is imperative for future growth and development of the insurance sector. We extend our previous work on factors affecting the decision to purchase health insurance to understand the factors affecting the renewal of insuran...

Determinants of internal migration in Kazakhstan

OpenAIRE

Aldashev, Alisher; Dietz, Barbara

2011-01-01

In this paper we analyze the determinants of interregional migration in Kazakhstan using quarterly panel data on region to region migration in 2008–2010. To the best of our knowledge this is the first study on interregional population flows in Central Asia. We find that migration is determined by economic factors, first of all income: People are more likely to leave regions where incomes are low and more likely to move to regions with a higher income level. Furthermore, mobility is larger bet...

Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.

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Anne N Shemon

2009-06-01

Full Text Available Raf Kinase Inhibitory Protein (RKIP, also PEBP1, a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway. Since an organic compound, locostatin, was reported to bind RKIP and inhibit cell migration by a Raf-dependent mechanism, we addressed the role of RKIP in locostatin function.We analyzed locostatin interaction with RKIP and examined the biological consequences of locostatin binding on RKIP function. NMR studies show that a locostatin precursor binds to the conserved phosphatidylethanolamine binding pocket of RKIP. However, drug binding to the pocket does not prevent RKIP association with its inhibitory target, Raf-1, nor affect RKIP phosphorylation by Protein Kinase C at a regulatory site. Similarly, exposure of wild type, RKIP-depleted HeLa cells or RKIP-deficient (RKIP(-/- mouse embryonic fibroblasts (MEFs to locostatin has no effect on MAP kinase activation. Locostatin treatment of wild type MEFs causes inhibition of cell migration following wounding. RKIP deficiency impairs migration further, indicating that RKIP protects cells against locostatin-mediated inhibition of migration. Locostatin treatment of depleted or RKIP(-/- MEFs reveals cytoskeletal disruption and microtubule abnormalities in the spindle.These results suggest that locostatin's effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling. The protective effect of RKIP against drug inhibition of migration suggests a new role for RKIP in potentially sequestering toxic compounds that may have deleterious effects on cells.

Raf Kinase Inhibitory Protein protects cells against locostatin-mediated inhibition of migration.

Science.gov (United States)

Shemon, Anne N; Eves, Eva M; Clark, Matthew C; Heil, Gary; Granovsky, Alexey; Zeng, Lingchun; Imamoto, Akira; Koide, Shohei; Rosner, Marsha Rich

2009-06-24

Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway. Since an organic compound, locostatin, was reported to bind RKIP and inhibit cell migration by a Raf-dependent mechanism, we addressed the role of RKIP in locostatin function. We analyzed locostatin interaction with RKIP and examined the biological consequences of locostatin binding on RKIP function. NMR studies show that a locostatin precursor binds to the conserved phosphatidylethanolamine binding pocket of RKIP. However, drug binding to the pocket does not prevent RKIP association with its inhibitory target, Raf-1, nor affect RKIP phosphorylation by Protein Kinase C at a regulatory site. Similarly, exposure of wild type, RKIP-depleted HeLa cells or RKIP-deficient (RKIP(-/-)) mouse embryonic fibroblasts (MEFs) to locostatin has no effect on MAP kinase activation. Locostatin treatment of wild type MEFs causes inhibition of cell migration following wounding. RKIP deficiency impairs migration further, indicating that RKIP protects cells against locostatin-mediated inhibition of migration. Locostatin treatment of depleted or RKIP(-/-) MEFs reveals cytoskeletal disruption and microtubule abnormalities in the spindle. These results suggest that locostatin's effects on cytoskeletal structure and migration are caused through mechanisms independent of its binding to RKIP and Raf/MAP kinase signaling. The protective effect of RKIP against drug inhibition of migration suggests a new role for RKIP in potentially sequestering toxic compounds that may have deleterious effects on cells.

The Last Adventure: Retirement Migration, Climate and "Amenities"

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Saša Božić

2001-12-01

Full Text Available The rising number of European retirement migrants on the Mediterranean coasts, especially in the EU countries shows that the practical and scientific relevance of the new forms of migration in Europe is on the rise. "Retirement migration" evolved from a descriptive term to a candidate for a scientific or a research concept, at least if the use of the term IRM (international retirement migration is considered. However, it is necessary to solve several problems before this term can really become a coherent concept, useful for the research and explanation of the "new" migration phenomena. The author claims that the studies usually do not distinguish clearly between the migration of the elderly and retirement migration. The naming of the concept in this case mixes the characteristics of the migrants with the reasons for migration. The author shows that the usually mentioned reasons for retirement migration cannot be clearly formulated as factors which explain retirement migration. Further on, retirement as such is not a pull, push or staying put factor. Migration rates of retired, although rising, are still lower than the migration rates of the working age population and the Mediterranean coasts are also a destination for professionals who have the means to detach the job from the working place. Only a combination of conditions that enable migration and migration decisions, as well as a combination of motives and perceptions of reasons for migration, can partially "explain" retirement migration. One of the problems that has to be solved before retirement migration is affirmed as a concept is the treatment of the temporal and spatial dimension of the mobility of the retirement migrants. The author shows that a clear positioning of retirement migration on the temporal scale of mobility is hardly possible. Retirement migration is too wide and too complex a phenomenon to be easily localised in the temporal continuum. A similar problem emerges when the

Podoplanin increases the migration of human fibroblasts and affects the endothelial cell network formation: A possible role for cancer-associated fibroblasts in breast cancer progression.

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Jaroslaw Suchanski

Full Text Available In our previous studies we showed that in breast cancer podoplanin-positive cancer-associated fibroblasts correlated positively with tumor size, grade of malignancy, lymph node metastasis, lymphovascular invasion and poor patients' outcome. Therefore, the present study was undertaken to assess if podoplanin expressed by fibroblasts can affect malignancy-associated properties of breast cancer cells. Human fibroblastic cell lines (MSU1.1 and Hs 578Bst overexpressing podoplanin and control fibroblasts were co-cultured with breast cancer MDA-MB-231 and MCF7 cells and the impact of podoplanin expressed by fibroblasts on migration and invasiveness of breast cancer cells were studied in vitro. Migratory and invasive properties of breast cancer cells were not affected by the presence of podoplanin on the surface of fibroblasts. However, ectopic expression of podoplanin highly increases the migration of MSU1.1 and Hs 578Bst fibroblasts. The present study also revealed for the first time, that podoplanin expression affects the formation of pseudo tubes by endothelial cells. When human HSkMEC cells were co-cultured with podoplanin-rich fibroblasts the endothelial cell capillary-like network was characterized by significantly lower numbers of nodes and meshes than in co-cultures of endothelial cells with podoplanin-negative fibroblasts. The question remains as to how our experimental data can be correlated with previous clinical data showing an association between the presence of podoplanin-positive cancer-associated fibroblasts and progression of breast cancer. Therefore, we propose that expression of podoplanin by fibroblasts facilitates their movement into the tumor stroma, which creates a favorable microenvironment for tumor progression by increasing the number of cancer-associated fibroblasts, which produce numerous factors affecting proliferation, survival and invasion of cancer cells. In accordance with this, the present study revealed for the first

Podoplanin increases the migration of human fibroblasts and affects the endothelial cell network formation: A possible role for cancer-associated fibroblasts in breast cancer progression.

Science.gov (United States)

Suchanski, Jaroslaw; Tejchman, Anna; Zacharski, Maciej; Piotrowska, Aleksandra; Grzegrzolka, Jedrzej; Chodaczek, Grzegorz; Nowinska, Katarzyna; Rys, Janusz; Dziegiel, Piotr; Kieda, Claudine; Ugorski, Maciej

2017-01-01

In our previous studies we showed that in breast cancer podoplanin-positive cancer-associated fibroblasts correlated positively with tumor size, grade of malignancy, lymph node metastasis, lymphovascular invasion and poor patients' outcome. Therefore, the present study was undertaken to assess if podoplanin expressed by fibroblasts can affect malignancy-associated properties of breast cancer cells. Human fibroblastic cell lines (MSU1.1 and Hs 578Bst) overexpressing podoplanin and control fibroblasts were co-cultured with breast cancer MDA-MB-231 and MCF7 cells and the impact of podoplanin expressed by fibroblasts on migration and invasiveness of breast cancer cells were studied in vitro. Migratory and invasive properties of breast cancer cells were not affected by the presence of podoplanin on the surface of fibroblasts. However, ectopic expression of podoplanin highly increases the migration of MSU1.1 and Hs 578Bst fibroblasts. The present study also revealed for the first time, that podoplanin expression affects the formation of pseudo tubes by endothelial cells. When human HSkMEC cells were co-cultured with podoplanin-rich fibroblasts the endothelial cell capillary-like network was characterized by significantly lower numbers of nodes and meshes than in co-cultures of endothelial cells with podoplanin-negative fibroblasts. The question remains as to how our experimental data can be correlated with previous clinical data showing an association between the presence of podoplanin-positive cancer-associated fibroblasts and progression of breast cancer. Therefore, we propose that expression of podoplanin by fibroblasts facilitates their movement into the tumor stroma, which creates a favorable microenvironment for tumor progression by increasing the number of cancer-associated fibroblasts, which produce numerous factors affecting proliferation, survival and invasion of cancer cells. In accordance with this, the present study revealed for the first time, that such

Factors Affecting Faculty Web Portal Usability

Science.gov (United States)

Bringula, Rex P.; Basa, Roselle S.

2011-01-01

The study investigated the factors that might significantly affect web portal usability. Results of the study were intended to serve as inputs for faculty web portal development of the University of the East-Manila. Descriptive statistics utilized questionnaire data from 82 faculty members. The data showed that most of the respondents were…

The Expression of Leptin, Estrogen Receptors, and Vitellogenin mRNAs in Migrating Female Chum Salmon, : The Effects of Hypo-osmotic Environmental Changes

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Young Jae Choi

2014-04-01

Full Text Available Leptin plays an important role in energy homeostasis and reproductive function in fish, especially in reproduction. Migrating fish, such as salmonoids, are affected by external environmental factors, and salinity changes are a particularly important influence on spawning migrations. The aim of this study was to test whether changes in salinity affect the expression of leptin, estrogen receptors (ERs, and vitellogenin (VTG in chum salmon (Oncorhynchus keta. The expression and activity of leptin, the expression of ERs and VTG, and the levels of estradiol-17β and cortisol increased after the fish were transferred to FW, demonstrating that changes in salinity stimulate the HPG axis in migrating female chum salmon. These findings reveal details about the role of elevated leptin levels and sex steroid hormones in stimulating sexual maturation and reproduction in response to salinity changes in chum salmon.

Determination of the factors that control migration and entry of radon into basements

International Nuclear Information System (INIS)

Borak, T.B.; Gadd, M.S.; Ward, D.C.; Barry, M.S.

1992-01-01

'Full Text:' Elevated concentrations of radon gas indoors are the result or a complicated combination of factors. This report describes results from a facility designed to test and verify theories of radon migration into underground structures. The buildings resemble miniature basements using conventional construction methods, hut eliminate other confounding factors introduced by the activities of occupants. Sensors accumulate data on soil properties such as temperature, moisture, pressure differentials, and permeability, as well as outdoor meteorological conditions and indoor environment. Results indicate that indoor radon concentrations do not correlate with changes in the adjacent soil gas concentration or the rate that radon enters the structure. When no attempt is made to control the indoor environment, periods of highest indoor concentration occur when the rate of entry is low. Methods to identify the driving mechanisms and implication for mitigation and control will he described. (author)

Probabilistic income-maximizing behavior in regional migration: an empirical test.

Science.gov (United States)

Weinstein, R I; Evans, R D

1980-01-01

"This paper provides an empirical test of the hypothesis that migrants consider income risk in their evaluation of the returns to migration in that higher levels of income risk for a given region reduce the rate of net migration into that region." Theoretical approaches to the incorporation of income risk in migration models are first considered, and alternative approaches are then tested using data on white and nonwhite net migration in the United States between 1960 and 1970. The results indicate support for the hypothesis that the extent of net migration is inversely affected by income risk. excerpt

Gender factors affecting female labour input in the Nigerian ...

African Journals Online (AJOL)

Gender factors affecting female labour input in the Nigerian University system. ... which mostly affect women‟s job performance in the Nigerian university system. ... are essential in building a gender-friendly university work environment.

Socio-Economic Determinants of International Migration

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Yaroslav PRYTULA

2012-05-01

Full Text Available Since economic factors cannot fully explain the determinants of bilateral migration, this study explores the social and cultural determinants that influence an individual’s decision to migrate. Values, norms and interests in a given culture, may determine whether an individual’s intention to move translates into actual migration. Work values inherent in different cultures could explain why people move or do not move under the condition of perceived economic advantages of migration. A gravity type migration model is used to incorporate variables related both to economic indicators and work values. It is perhaps the first migration study to use the World Value Survey (WVS and the European Value Survey (EVS. We use 2000 stock bilateral migration dataset collected by the World Bank. Our findings indicate that if more aspects of work are valued in a country, this country sends more migrants. Also we show that countries with higher extrinsic work value orientation tend to send more migrants, while countries with higher intrinsic work value orientation tend to send fewer migrants. Our finding shows that the value of work and the level of job security in a country may significantly change migration decision.

Theories of international labor migration: an overview.

Science.gov (United States)

Stahl, C W

1995-01-01

"Emigration pressures are primarily the result of increasing inequalities between countries which, in turn, are the result of factors internal to less developed countries and their relations with developed countries. Both micro (neoclassical) and macrostructural theories of migration are reviewed. It is argued that the neoclassical theory of migration is often unjustly criticized and is sufficiently robust to incorporate those structural considerations which are at the core of macrostructural theories. Moreover, the neoclassical theory, with slight modification, can incorporate the ¿new economics of migration.' The major empirical problem confronting models of international labor migration is that migration flows are constrained by immigration policy. This policy, in turn, is influenced by various special interest groups. The direction and form of migration flows is conditioned by contemporary and historical relationships between source and destination countries." excerpt

Variability in connectivity patterns of fish with ontogenetic migrations: Modelling effects of abiotic and biotic factors

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Susanne Eva Tanner

2015-10-01

Full Text Available Connectivity is a critical property of marine fish populations as it drives population replenishment, determines colonization patterns and the resilience of populations to harvest. Understanding connectivity patterns is particularly important in species that present ontogenetic migrations and segregated habitat use during their life history, such as marine species with estuarine nursery areas. Albeit challenging, fish movement can be estimated and quantified using different methodologies depending on the life history stages of interest (e.g. biophysical modelling, otolith chemistry, genetic markers. Relative contributions from estuarine nursery areas to the adult coastal populations were determined using otolith elemental composition and maximum likelihood estimation for four commercially important species (Dicentrarchus labrax, Plathichtys flesus, Solea senegalensis and Solea solea and showed high interannual variability. Here, the effects of abiotic and biotic factors on the observed variability in connectivity rates and extent between estuarine juvenile and coastal adult subpopulations are investigated using generalized linear models (GLM and generalized mixed models (GMM. Abiotic factors impacting both larval and juvenile life history stages are included in the models (e.g. wind force and direction, NAO, water temperature while biotic factors relative to the estuarine residency of juvenile fish are evaluated (e.g. juvenile density, food availability. Factors contributing most to the observed variability in connectivity rates are singled out and compared among species. General trends are identified and results area discussed in the general context of identifying potential management frameworks applicable to different life stages and which may prove useful for ontogenetically migrating species.

Investigation of Factors Affecting Microdialysis Probe Delivery and ...

African Journals Online (AJOL)

Purpose: To investigate in vitro the factors affecting microdialysis probe delivery and recovery of puerarin. Methods: The recovery and delivery of puerarin were tested for extraction efficiency and retro-dialysis methods. Factors such as drug concentration, stirring speed, additives and length of membrane were studied to ...

Investigation of Factors Affecting Microdialysis Probe Delivery and ...

African Journals Online (AJOL)

Purpose: To investigate in vitro the factors affecting microdialysis probe delivery and recovery of puerarin . Methods: The recovery and delivery of puerarin were tested for extraction efficiency and retro-dialysis methods. Factors such as drug concentration, stirring speed, additives and length of membrane were studied to ...

7339 BASELINE SURVEY ON FACTORS AFFECTING SORGHUM ...

African Journals Online (AJOL)

muuicathy

2013-01-01

Jan 1, 2013 ... factors affecting sorghum production and the sorghum farming ... The informal seed system includes methods such as retaining seed on-farm from ..... Jaetzold R and H Schmidt Farm Management Handbook of Kenya, Ministry.

Expectations, gender, and norms in migration decision-making.

Science.gov (United States)

DE Jong, Gordon F

2000-01-01

This paper argues that expectations - the process of evaluating the chances for future attainment of valued goals in the home community (stay decision) vs. alternative locations (move decision) - along with family norms about migration are major predictors of intention to move, which in turn is a proximate determinant of migration behaviour. Utilizing longitudinal data from the 1992 and 1994 waves of the Thailand National Migration Survey, logistic regression models show that a strikingly different set of expectations, household demographic indicators, and migrant capital factors were significant determinants of migration intentions for men and women; reflecting Thai gender roles. Migration intentions, in turn, predicted more permanent, but not temporary, survival strategy migration behaviour, while low household income predicted temporary but not more permanent migration behaviour. The measure of perceived family migration norms was a powerful determinant of migration behaviour, but the size of migrant networks was not a statistically significant determinant of either migration intentions or behaviour.

Temperature as a proximate factor in orientation behavior

Energy Technology Data Exchange (ETDEWEB)

Reynolds, W.W.

1977-05-01

Temperature serves as a proximate factor (cue, guidepost, sign stimulus, or directive factor) affecting locomotor responses of fishes. Although temperature can also serve as an ultimate ecological factor, as in behavioral thermoregulation, nonthermal factors may in some cases provide the ultimate adaptive or ecological value of a temperature response; some examples are habitat selection, intraspecific size segregation, interspecific niche differentiation, isolating mechanisms, predator avoidance, prey location, escape reactions, and migrations (thermoperiodic, diel, seasonal, spawning). Conversely, nonthermal variables such as light intensity or water depth may act as accessory proximate factors in thermoregulation. In spawning migrations, thermal requirements of eggs and larvae may take precedence over the (often different) preferenda or optima of adults. Although thermal responses of fishes are largely innate and species specific, ontogenetic and other changes can occur. Since temperature can serve as an unconditioned reinforcer in operant conditioning, thermal responses are not limited to simple kineses or taxes. Nonthermal factors such as photoperiod, circadian rhythms, currents, social and biotic interactions, stresses, infections, or chemicals can affect thermal responses, and may account for some lack of conformity between laboratory preferenda and field distributions and behaviors.

Analysis of Economic Factors Affecting Stock Market

OpenAIRE

Xie, Linyin

2010-01-01

This dissertation concentrates on analysis of economic factors affecting Chinese stock market through examining relationship between stock market index and economic factors. Six economic variables are examined: industrial production, money supply 1, money supply 2, exchange rate, long-term government bond yield and real estate total value. Stock market comprises fixed interest stocks and equities shares. In this dissertation, stock market is restricted to equity market. The stock price in thi...

Migration and common mental disorder: an improvement in mental health over time?

Science.gov (United States)

Butler, Margaret; Warfa, Nasir; Khatib, Yasmin; Bhui, Kamaldeep

2015-02-01

Global migration is reaching record high levels and UK migrant groups comprise an increasing proportion of the total population. The migratory process causes stress that can affect mental health. There is limited consistent empirical evidence of a longitudinal nature to explain the association between migration and mental health. This review aims to examine the evidence of a relationship between migration and common mental disorder (CMD) amongst migrants over time. A comprehensive search of medical and psychiatric databases for global quantitative empirical studies investigating incidence of CMD amongst adult migrants from 1975 to July 2012 was conducted. Declines in rates of CMD amongst migrants over time were reported by two thirds of the 18 studies reviewed, less than one third of which were statistically significant. On the contrary, three studies showed an increased rate of CMD, one statistically significant. Individual psychological resources, social support, the acculturation process, cultural variations and time since relocation are identified as statistically significant protective factors against the development of CMD amongst migrants. New enlightening points include the significant impact of varying patterns of psychological distress, of which negative is the most adverse for CMD. Migration is an extremely complex process. Further clarification is needed to gain deeper understanding of the relationship between migration and CMD to address contradictions in the literature and health inequalities amongst migrants.

Factors Affecting Learning Among Undergraduate Nursing Students: Cross-Sectional Survey

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Linu Sara George

2017-11-01

Full Text Available Introduction: Nursing education expects the students to be competent enough to render quality care for their patients in hospital as well as community setting. To reach the level of expected competency, the students must undergo vigorous training during their undergraduate education. The learning experience of the students is influenced by many factors. Aim: To identify the factors, affecting learning as perceived by the students. Materials and Methods: This descriptive survey was conducted among 414 undergraduate nursing students enrolled in selected Nursing Colleges. Background information was collected using Demographic Proforma and the factors affecting learning were identified using Likert Scale. Factors were identified by exploratory factor analysis using extraction method of principal component analysis with varimax rotation. Results: Majority (73.7% of the samples were between 22-25 years of age, 93.2% were females, most (38.9% were studying in the fourth year of nursing, 50% of the students enrolled in the study had chosen nursing as a career due to job security in future, 58.7% students did not spent time every day for their studies and majority (89.1% had English as their medium of instruction in Pre-university college. Factor analysis identified five factors (Learning environment, Supportive services, Teacher characteristics, Learner challenges and Personal factors that affect the student learning. Conclusion: From the present study it can be concluded that perception of students do have an influence on factors affecting learning. The study findings will help the faculty members to bring in changes for the best learning outcome.

Substrate-Related Factors Affecting Enzymatic Saccharification of Lignocelluloses: Our Recent Understanding

Science.gov (United States)

Shao-Yuan Leu; J.Y. Zhu

2013-01-01

Enzymatic saccharification of cellulose is a key step in conversion of plant biomass to advanced biofuel and chemicals. Many substrate-related factors affect saccharification. Rather than examining the role of each individual factor on overall saccharification efficiency, this study examined how each factor affects the three basic processes of a heterogeneous...

Impact of cell shape on cell migration behavior on elastic substrate

International Nuclear Information System (INIS)

Zhong Yuan; Ji Baohua

2013-01-01

Cell shape is known to have profound effects on a number of cell behaviors. In this paper we have studied its role in cell migration through modeling the effect of cell shape on the cell traction force distribution, the traction force dependent stability of cell adhesion and the matrix rigidity dependent traction force formation. To quantify the driving force of cell migration, a new parameter called the motility factor, that takes account of the effect of cell shape, matrix rigidity and dynamic stability of cell adhesion, is proposed. We showed that the motility factor depends on the matrix rigidity in a biphasic manner, which is consistent with the experimental observations of the biphasic dependence of cell migration speed on the matrix rigidity. We showed that the cell shape plays a pivotal role in the cell migration behavior by regulating the traction force at the cell front and rear. The larger the cell polarity, the larger the motility factor is. The keratocyte-like shape has a larger motility factor than the fibroblast-like shape, which explains why keratocyte has a much higher migration speed. The motility factor might be an appropriate parameter for a quantitative description of the driving force of cell migration. (paper)

Why sub-Saharan African health workers migrate to European countries that do not actively recruit: a qualitative study post-migration.

Science.gov (United States)

Poppe, Annelien; Jirovsky, Elena; Blacklock, Claire; Laxmikanth, Pallavi; Moosa, Shabir; De Maeseneer, Jan; Kutalek, Ruth; Peersman, Wim

2014-01-01

Many studies have investigated the migration intentions of sub-Saharan African medical students and health professionals within the context of a legacy of active international recruitment by receiving countries. However, many health workers migrate outside of this recruitment paradigm. This paper aims to explore the reasons for migration of health workers from sub-Saharan Africa to Belgium and Austria; European countries without a history of active recruitment in sub-Saharan Africa. Data were collected using semistructured interviews. Twenty-seven health workers were interviewed about their migration experiences. Included participants were born in sub-Saharan Africa, had trained as health workers in sub-Saharan Africa, and were currently living in Belgium or Austria, though not necessarily currently working as a health professional. Both Austria and Belgium were shown not to be target countries for the health workers, who instead moved there by circumstance, rather than choice. Three principal reasons for migration were reported: 1) educational purposes; 2) political instability or insecurity in their country of origin; and 3) family reunification. In addition, two respondents mentioned medical reasons and, although less explicit, economic factors were also involved in several of the respondents' decision to migrate. These results highlight the importance of the broader economic, social, and political context within which migration decisions are made. Training opportunities proved to be an important factor for migration. A further development and upgrade of primary care might help to counter the common desire to specialize and improve domestic training opportunities.

A preliminary study of international migration of the Chinese people.

Science.gov (United States)

Zhu, G

1994-01-01

International Chinese migration has spanned five periods: 1) an initial period of random and short-term migration dating back to the Qing and Han dynasties; 2) a spontaneous period since the Sui and Tang dynasties along trade routes; 3) a transition period during the Ming dynasty and the early Qing dynasty with war, poverty, and population growth as push factors; 4) peak migration during the Opium War period due to economic depression, population pressure, and the "coolie" trade; and 5) continuous development between the 1920s and 1949. Migration tended to occur between Guangdong and Fujian provinces and other southeast Asian countries. Four factors were identified as necessary for international migration to occur: the origin of migration, the destination factor, the middle link factor, and the immigrant characteristics. The origins of early Chinese migration appeared in a country of political corruption, population pressure, a backward economy, and social chaos. The pull factors at destination end were demand for labor. The middle link was the short distance between Guangdong and Fujian provinces and southeast Asian countries and longstanding nongovernmental exchanges. Other links were the similarity of climate, similar racial features, cultural lifestyle similarities, and convenient transportation. The people in these two provinces had a history of migration and a personality suitable for the spirit of adventure. Peak migration occurred during the late Qing dynasty and during the continuous development period. Between 1840 and 1911 there were about 10 million Chinese immigrants and during 1911 and 1949 there were about 6 million. In general, over 20 million immigrated prior to 1949, of which about 50% migrated during the peak period, 33% during the continuous period, and 20% before 1840. This amounted to about 33% of European migration and two times African migration. 60% were from Guangdong, and 30% were from Fujian province, of whom most were from counties

Ion Migration in Organometal Trihalide Perovskite and Its Impact on Photovoltaic Efficiency and Stability.

Science.gov (United States)

Yuan, Yongbo; Huang, Jinsong

2016-02-16

Organometal trihalide perovskites (OTPs) are emerging as very promising photovoltaic materials because the power conversion efficiency (PCE) of OTP solar cells quickly rises and now rivals with that of single crystal silicon solar cells after only five-years research. Their prospects to replace silicon photovoltaics to reduce the cost of renewable clean energy are boosted by the low-temperature solution processing as well as the very low-cost raw materials and relative insensitivity to defects. The flexibility, semitransparency, and vivid colors of perovskite solar cells are attractive for niche applications such as built-in photovoltaics and portable lightweight chargers. However, the low stability of current hybrid perovskite solar cells remains a serious issue to be solved before their broad application. Among all those factors that affect the stability of perovskite solar cells, ion migration in OTPs may be intrinsic and cannot be taken away by device encapsulation. The presence of ion migration has received broad attention after the report of photocurrent hysteresis in OTP based solar cells. As suggested by much direct and indirect experimental evidence, the ion migration is speculated to be the origin or an important contributing factor for many observed unusual phenomenon in OTP materials and devices, such as current-voltage hysteresis, switchable photovoltaic effect, giant dielectric constant, diminished transistor behavior at room temperature, photoinduced phase separation, photoinduced self-poling effect, and electrical-field driven reversible conversion between lead iodide (PbI2) and methylammonium lead triiodide (MAPbI3). Undoubtedly thorough insight into the ion-migration mechanism is highly desired for the development of OTP based devices to improve intrinsic stability in the dark and under illumination. In this Account, we critically review the recent progress in understanding the fundamental science on ion migration in OTP based solar cells. We look

Interregional migration in Indonesia. Macro, micro, and agent-based modelling approaches

NARCIS (Netherlands)

Wajdi, N.

2017-01-01

This thesis aims to explain the dynamics of interregional migration in Indonesia in the 2000-2010 period and to project migration dynamics up to 2035. Four empirical studies presented in this thesis are interregional migration flows in Indonesia, migration and its relation to macro factors,

Evolution of mammalian migrations for refuge, breeding, and food.

Science.gov (United States)

Gnanadesikan, Gitanjali E; Pearse, William D; Shaw, Allison K

2017-08-01

Many organisms migrate between distinct habitats, exploiting variable resources while profoundly affecting ecosystem services, disease spread, and human welfare. However, the very characteristics that make migration captivating and significant also make it difficult to study, and we lack a comprehensive understanding of which species migrate and why. Here we show that, among mammals, migration is concentrated within Cetacea and Artiodactyla but also diffusely spread throughout the class (found in 12 of 27 orders). We synthesize the many ecological drivers of round-trip migration into three types of movement-between breeding and foraging sites, between breeding and refuge sites, and continuous tracking of forage/prey-each associated with different traits (body mass, diet, locomotion, and conservation status). Our results provide only partial support for the hypothesis that migration occurs without phylogenetic constraint. Furthermore, our findings suggest that categorizing migration into these three types may aid predictions of migrants' responses to environmental changes.

Migration strategy affects avian influenza dynamics in mallards (Anas platyrhynchos).

Science.gov (United States)

Takekawa, John Y.; Hill, Nichola J.; Ackerman, Joshua T.; Herring, Garth; Hobson, Keith; Cardona, Carol J.; Runstadler, Jonathan; Boyce, Walter M.

2012-01-01

Studies of pathogen transmission typically overlook that wildlife hosts can include both migrant and resident populations when attempting to model circulation. Through the application of stable isotopes in flight feathers, we estimated the migration strategy of mallards (Anas platyrhynchos) occurring on California wintering grounds. Our study demonstrates that mallards- a principal host of avian influenza virus (AIV) in nature, contribute differently to virus gene flow depending on migration strategy. No difference in AIV prevalence was detected between resident (9.6%), intermediate-distance (9.6%) and long-distance migrants (7.4%). Viral diversity among the three groups was also comparable, possibly owing to viral pool mixing when birds converge at wetlands during winter. However, migrants and residents contributed differently to the virus gene pool at wintering wetlands. Migrants introduced virus from northern breeding grounds (Alaska and the NW Pacific Rim) into the wintering population, facilitating gene flow at continental scales, but circulation of imported virus appeared to be limited. In contrast, resident mallards acted as AIV reservoirs facilitating year-round circulation of limited subtypes (i.e. H5N2) at lower latitudes. This study supports a model of virus exchange in temperate regions driven by the convergence of wild birds with separate geographic origins and exposure histories.

Demographic situation in territories of Russia affected by the Chernobyl accident

International Nuclear Information System (INIS)

Arutyunyan, R.; Linge, I.; Melikhova, E.; Pavlovski, O.

1996-01-01

Population statistics in the most contaminated territories in Russia are compared with those of reference populations. Changes of size and age structure of populations as well as migration, dynamics of birth-rate and mortality are followed for the period 1982-1994. Deviations of the affected population statistics from a common trend are shown to be connected with social factors arising from countermeasures implemented in the zones but not with the radiation factor itself. (Author)

Factors affecting the rural domestic waste generation

Directory of Open Access Journals (Sweden)

A.R. Darban Astane

2017-12-01

Full Text Available The current study was carried out to evaluate the quantity and quality of rural domestic waste generation and to identify the factors affecting it in rural areas of Khodabandeh county in Zanjan Province, Iran. Waste samplings consisted of 318 rural households in 11 villages. In order to evaluate the quality and quantity of the rural domestic waste, waste production was classified into 12 groups and 2 main groups of organic waste and solid waste. Moreover, kriging interpolation technique in ARC-GIS software was used to evaluate the spatial distribution of the generated domestic waste and ultimately multiple regression analysis was used to evaluate the factors affecting the generation of domestic waste. The results of this study showed that the average waste generated by each person was 0.588 kilograms per day. with the share of organic waste generated by each person being 0.409 kilograms per day and the share of solid waste generated by each person being 0.179 kilograms per day. The results from spatial distribution of waste generation showed a certain pattern in three groups and a higher rate of waste generation in the northern and northwestern parts, especially in the subdistrict. The results of multiple regression analysis showed that the households’ income, assets, age, and personal attitude are respectively the most important variables affecting waste generation. The housholds’ attitude and indigenous knowledge on efficient use of materials are also the key factors which can help reducing waste generation.

Local temperature fine-tunes the timing of spring migration in birds

DEFF Research Database (Denmark)

Tøttrup, Anders P.; Rainio, Kalle; Coppack, Timothy

2010-01-01

and predict consequences of climatic change for migratory birds. In order to better understand migration phenology and adaptation in environmental changes, we here assess the scale at which weather affects timing of spring migration in passerine birds. We use three commonly used proxies of spring......-time climatic conditions: (1) vegetation "greenness" (NDVI) in Europe, (2) local spring temperatures in northern Europe, and (3) the North Atlantic Oscillation Index (NAO) as predictors of the phenology of avian migration as well as the strength of their effect on different subsets of populations...... breeding area. Local temperature was the best single predictor of phenology with the highest explanatory power achieved in combination with NAO. Furthermore, early individuals are more affected by climatic variation compared to individuals on later passage, indicating that climatic change affects subsets...

Retirement migration and military retirement

International Nuclear Information System (INIS)

1988-06-01

This report addresses questions relevant to a socioeconomic assessment system for southern Nevada. They point to an understanding of the magnitude of impacts which may occur if the Yucca Mountain Project were to affect the decision-making process which leads these groups to migrate to southern Nevada. This is an important but somewhat elusive topic lacking in standard data sources. However, the topic may be addressed and analyzed systematically. This report presents the results of efforts to develop a data base and begin development of a model to address the migration, income and expenditure dimensions of these groups. 1 fig., 62 tabs

Migrating and herniating hydatid cysts

International Nuclear Information System (INIS)

Koc, Zafer; Ezer, Ali

2008-01-01

Objective: To present the prevalence and imaging findings of patients with hydatid disease (HD) showing features of migration or herniation of the hydatid cysts (HCs) and underline the clinical significance of this condition. Materials and methods: Between May 2003 and June 2006, 212 patients with HD were diagnosed by abdomen and/or thorax CT, searched for migrating or herniating HC. Imaging findings of 7 patients (5 women, 2 men with an age range of 19-63 years; mean ± S.D., 44 ± 19 years) with HD showing transdiaphragmatic migration (6 subjects) or femoral herniation (1 subject) were evaluated. Diagnosis of all the patients were established by pathologic examination and migration or herniation was confirmed by surgery in all patients. Results: Liver HD were identified in 169 (79.7%) of 212 patients with HD. Transdiaphragmatic migration of HCs were identified in 6 (3.5%) of the 169 patients with liver HD. In one patient, femoral herniation of the retroperitoneal HC into the proximal anterior thigh was identified. All of these seven patients exhibiting migration or herniation of HCs had active HCs including 'daughter cysts'. Two patients had previous surgery because of liver HD and any supradiaphragmatic lesion was not noted before operation. Findings of migration or herniation were confirmed by surgery. Conclusion: Active HCs may show migration or herniation due to pressure difference between the anatomic cavities, and in some of the patients, by contribution of gravity. Previous surgery may be a complementary factor for migration as seen in two of our patients. The possibility of migration or herniation in patients with HD should be considered before surgery

Factors affecting the corrosion of SiC layer by fission product palladium

International Nuclear Information System (INIS)

Dewita, E.

2000-01-01

HTR is one of the advanced nuclear reactors which has inherent safety system, graphite moderated and helium gas cooled. In general, these reactors are designed with the TRISO coated particle consist of four coating layers that are porous pyrolytic carbon (PyC). inner dense PyC (IPyC), silicon carbide (SiC), and outer dense PyC (OPyC). Among the four coating layers, the SiC plays an important role beside in retaining metallic fission products, it also provides mechanical strength to fuel particle. However, results of post irradiation examination indicate that fission product palladium can react with and corrode SiC layer, This assessment is conducted to get the comprehension about resistance of SiC layer on irradiation effects, especially in order to increase the fuel bum-up. The result of this shows that the corrosion of SiC layer by fission product palladium is beside depend on the material characteristics of SiC, and also there are other factors that affect on the SiC layer corrosion. Fuel enrichment, bum-up, and irradiation time effect on the palladium flux in fuel kernel. While, the fuel density, vapour pressure of palladium (the degree depend on the irradiation temperature and kernel composition) effect on palladium migration in fuel particle. (author)

Regulators of Intestinal Epithelial Migration in Sepsis.

Science.gov (United States)

Meng, Mei; Klingensmith, Nathan J; Liang, Zhe; Lyons, John D; Fay, Katherine T; Chen, Ching-Wen; Ford, Mandy L; Coopersmith, Craig M

2018-02-08

The gut is a continuously renewing organ, with cell proliferation, migration and death occurring rapidly under basal conditions. Since the impact of critical illness on cell movement from crypt base to villus tip is poorly understood, the purpose of this study was to determine how sepsis alters enterocyte migration. Wild type, transgenic and knockout mice were injected with 5-bromo-2'deoxyuridine (BrdU) to label cells in S phase before and after the onset of cecal ligation and puncture and were sacrificed at pre-determined endpoints to determine distance proliferating cells migrated up the crypt-villus unit. Enterocyte migration rate was decreased from 24-96 hours following sepsis. BrdU was not detectable on villi 6 days after sham laparotomy, meaning all cells had migrated the length of the gut and been exfoliated into its lumen. However, BrdU positive cells were detectable on villi 10 days after sepsis. Multiple components of gut integrity altered enterocyte migration. Sepsis decreased crypt proliferation, which further slowed enterocyte transit as mice injected with BrdU after the onset of sepsis (decreased proliferation) had slower migration than mice injected with BrdU prior to the onset of sepsis (normal proliferation). Decreasing intestinal apoptosis via gut-specific overexpression of Bcl-2 prevented sepsis-induced slowing of enterocyte migration. In contrast, worsened intestinal hyperpermeability by genetic deletion of JAM-A increased enterocyte migration. Sepsis therefore significantly slows enterocyte migration, and intestinal proliferation, apoptosis and permeability all affect migration time, which can potentially be targeted both genetically and pharmacologically.

Ranking and evaluating the factors affecting the success of ...

African Journals Online (AJOL)

Ranking and evaluating the factors affecting the success of management team in construction projects. ... Journal of Fundamental and Applied Sciences. Journal Home ... The project management team is one of these important factors.

Migration: a concept analysis from a nursing perspective.

Science.gov (United States)

Freeman, Michelle; Baumann, Andrea; Blythe, Jennifer; Fisher, Anita; Akhtar-Danesh, Noori

2012-05-01

  This article is a report of a concept analysis of nurse migration.   International migration is increasing and nurse migrants are active participants in this movement. Migration is a complex term and can be examined from a range of perspectives. Analysis of nurse migration is needed to guide policy, practice and research.   A literature search was undertaken using electronic literature indexes, specific journals and websites, internet search engines and hand searches. No timeframe was placed on the search. Most literature found was published between 2001 and 2009. A sample of 80 documents met the inclusion criteria.   Walker and Avant's approach guided the analysis.   Nurse migration can be defined by five attributes: the motivation and decisions of individuals; external barriers and facilitators; freedom of choice to migrate; freedom to migrate as a human right, and dynamic movement. Antecedents of migration include the political, social, economic, legal, historical and educational forces that comprise the push and pull framework. The consequences of migration are positive or negative depending on the viewpoint and its affect on the individual and other stakeholders such as the source country, destination country, healthcare systems and the nursing profession.   This concept analysis clarified the complexities surrounding nurse migration. A nursing-specific middle-range theory was proposed to guide the understanding and study of nurse migration. © 2011 Blackwell Publishing Ltd.

International migration patterns of physicians to the United States: a cross-national panel analysis.

Science.gov (United States)

Hussey, Peter S

2007-12-01

To analyze the dynamics of physician international migration patterns and identify the countries deviating most from expected migration rates. A negative binomial log-linear model of physician migration to the United States from every other country was constructed using a panel of country-level data for years 1994-2000. The model was used to identify factors associated with physician migration and to identify countries with higher or lower rates of physician migration than expected. Physician migration varied with a country's GDP per capita in an inverse-U pattern, with highest migration rates from middle-income countries. The absence of medical schools, immigrant networks in the United States, medical instruction in English, proximity to the United States, and the lack of political and civil liberties were also associated with higher migration rates. Countries with higher-than-predicted migration rates included Iceland, Albania, Armenia, Dominica, Lebanon, Syria, the United Arab Emirates, and Bulgaria. Countries with lower-than-predicted migration rates included Mexico, Japan, Brazil, Zimbabwe, Mauritania, Portugal, Senegal, and France. This analysis shows that many of the most powerful factors associated with physician migration are difficult or impossible for countries to change through public policy. GDP per capita and proximity to the U.S. are two of the most powerful predictors of physician migration. Networks of immigrants in the U.S. and fewer political and civil liberties also put countries at higher risk for physician emigration. Several other factors that were associated with physician migration might be more easily amenable to policy intervention. These factors include the absence of a medical school and medical instruction in English. Policies addressing these factors would involve making several difficult tradeoffs, however. Other examples of policies that are effective in minimizing physician migration might be found by examining countries with lower

An economic analysis of migration in Mexico.

Science.gov (United States)

Greenwood, M J; Ladman, J R

1978-07-01

This paper analyzes internal migration in Mexico over the 1960-70 period. A model of the determinants of migration is specified and estimated for aggregated interstate migration flows. Results show that distance serves as a significant deterrent to migration, that higher destination earning levels are attractive to migrants, and that regions with high unemployment rates experience lower rates of inmigration. An unanticipated finding is that regions with higher earning levels have greater rates of outmigration. The data are disaggregated to examine separate migration relationships for each state. The results are that distance is a lesser deterrent for those migrants with more accessible alternatives, that higher earning levels reduce the deterring effects of distance, and that regions with higher earning levels have lower associated elasticities of migration. It is concluded that economic factors have played a crucial role in internal migration and thus in the changing occupational and geographic structure of the Mexican labor force.

Factors Affecting the Pharmacology of Antibody–Drug Conjugates

Directory of Open Access Journals (Sweden)

Andrew T. Lucas

2018-02-01

Full Text Available Major advances in therapeutic proteins, including antibody–drug conjugates (ADCs, have created revolutionary drug delivery systems in cancer over the past decade. While these immunoconjugate agents provide several advantages compared to their small-molecule counterparts, their clinical use is still in its infancy. The considerations in their development and clinical use are complex, and consist of multiple components and variables that can affect the pharmacologic characteristics. It is critical to understand the mechanisms employed by ADCs in navigating biological barriers and how these factors affect their biodistribution, delivery to tumors, efficacy, and toxicity. Thus, future studies are warranted to better understand the complex pharmacology and interaction between ADC carriers and biological systems, such as the mononuclear phagocyte system (MPS and tumor microenvironment. This review provides an overview of factors that affect the pharmacologic profiles of ADC therapies that are currently in clinical use and development.

Factors affecting strategic plan implementation using interpretive structural modeling (ISM).

Science.gov (United States)

Bahadori, Mohammadkarim; Teymourzadeh, Ehsan; Tajik, Hamidreza; Ravangard, Ramin; Raadabadi, Mehdi; Hosseini, Seyed Mojtaba

2018-06-11

Purpose Strategic planning is the best tool for managers seeking an informed presence and participation in the market without surrendering to changes. Strategic planning enables managers to achieve their organizational goals and objectives. Hospital goals, such as improving service quality and increasing patient satisfaction cannot be achieved if agreed strategies are not implemented. The purpose of this paper is to investigate the factors affecting strategic plan implementation in one teaching hospital using interpretive structural modeling (ISM). Design/methodology/approach The authors used a descriptive study involving experts and senior managers; 16 were selected as the study sample using a purposive sampling method. Data were collected using a questionnaire designed and prepared based on previous studies. Data were analyzed using ISM. Findings Five main factors affected strategic plan implementation. Although all five variables and factors are top level, "senior manager awareness and participation in the strategic planning process" and "creating and maintaining team participation in the strategic planning process" had maximum drive power. "Organizational structure effects on the strategic planning process" and "Organizational culture effects on the strategic planning process" had maximum dependence power. Practical implications Identifying factors affecting strategic plan implementation is a basis for healthcare quality improvement by analyzing the relationship among factors and overcoming the barriers. Originality/value The authors used ISM to analyze the relationship between factors affecting strategic plan implementation.

Pre-migration Trauma Exposure and Psychological Distress for Asian American Immigrants: Linking the Pre- and Post-migration Contexts.

Science.gov (United States)

Li, Miao; Anderson, James G

2016-08-01

Drawing on the life course perspective and the assumptive world theory, this paper examines whether pre-migration trauma exposure is associated with psychological distress through post-migration perceived discrimination for Asian American immigrants. The study is based on cross-sectional data from the National Latino and Asian American Study (N = 1639). Structural equation model is used to estimate the relationship between pre-migration trauma, post-migration perceived discrimination, and psychological distress. Additional models are estimated to explore possible variations across ethnic groups as well as across different types of pre-migration trauma experience. Pre-migration trauma exposure is associated with higher levels of psychological distress, both directly and indirectly through higher level of perceived discrimination, even after controlling for demographic/acculturative factors and post-migration trauma exposure. This pattern holds for the following sub-types of pre-migration trauma: political trauma, crime victimization, physical violence, accidental trauma, and relational trauma. Multi-group analyses show that this pattern holds for all Asian immigrant subgroups except the Vietnamese. Studies of immigrant mental health primarily focus on post-migration stressors. Few studies have considered the link between pre- and post-migration contexts in assessing mental health outcomes. The study illustrates the usefulness of bridging the pre- and post-migration context in identifying the mental health risks along the immigrant life course.

Entropy measures of collective cell migration

Science.gov (United States)

Whitby, Ariadne; Parrinello, Simona; Faisal, Aldo

2015-03-01

Collective cell migration is a critical process during tissue formation and repair. To this end there is a need to develop tools to quantitatively measure the dynamics of collective cell migration obtained from microscopy data. Drawing on statistical physics we use entropy of velocity fields derived from dense optic flow to quantitatively measure collective migration. Using peripheral nerve repair after injury as experimental system, we study how Schwann cells, guided by fibroblasts, migrate in cord-like structures across the cut, paving a highway for neurons. This process of emergence of organised behaviour is key for successful repair, yet the emergence of leader cells and transition from a random to ordered state is not understood. We find fibroblasts induce correlated directionality in migrating Schwann cells as measured by a decrease in the entropy of motion vector. We show our method is robust with respect to image resolution in time and space, giving a principled assessment of how various molecular mechanisms affect macroscopic features of collective cell migration. Finally, the generality of our method allows us to process both simulated cell movement and microscopic data, enabling principled fitting and comparison of in silico to in vitro. ICCS, Imperial College London & MRC Clinical Sciences Centre.

Characterization of the activities of actin-affecting drugs on tumor cell migration

International Nuclear Information System (INIS)

Hayot, Caroline; Debeir, Olivier; Ham, Philippe van; Damme, Marc van; Kiss, Robert; Decaestecker, Christine

2006-01-01

Metastases kill 90% of cancer patients. It is thus a major challenge in cancer therapy to inhibit the spreading of tumor cells from primary tumor sites to those particular organs where metastases are likely to occur. Whereas the actin cytoskeleton is a key component involved in cell migration, agents targeting actin dynamics have been relatively poorly investigated. Consequently, valuable in vitro pharmacological tools are needed to selectively identify this type of agent. In response to the absence of any standardized process, the present work aims to develop a multi-assay strategy for screening actin-affecting drugs with anti-migratory potentials. To validate our approach, we used two cancer cell lines (MCF7 and A549) and three actin-affecting drugs (cytochalasin D, latrunculin A, and jasplakinolide). We quantified the effects of these drugs on the kinetics of actin polymerization in tubes (by means of spectrofluorimetry) and on the dynamics of actin cytoskeletons within whole cells (by means of fluorescence microscopy). Using quantitative videomicroscopy, we investigated the actual effects of the drugs on cell motility. Finally, the combined drug effects on cell motility and cell growth were evaluated by means of a scratch-wound assay. While our results showed concordant drug-induced effects on actin polymerization occurring in vitro in test tubes and within whole cells, the whole cell assay appeared more sensitive than the tube assay. The inhibition of actin polymerization induced by cytochalasin D was paralleled by a decrease in cell motility for both cell types. In the case of jasplakinolide, which induces actin polymerization, while it significantly enhanced the locomotion of the A549 cells, it significantly inhibited that of the MCF-7 ones. All these effects were confirmed by means of the scratch-wound assay except of the jasplakinolide-induced effects on MCF-7 cell motility. These later seemed compensated by an additional effect occurring during wound

Exploring paraprofessional and classroom factors affecting teacher supervision.

Science.gov (United States)

Irvin, Dwight W; Ingram, Paul; Huffman, Jonathan; Mason, Rose; Wills, Howard

2018-02-01

Paraprofessionals serve a primary role in supporting students with disabilities in the classroom, which necessitates teachers' supervision as a means to improve their practice. Yet, little is known regarding what factors affect teacher supervision. We sought to identify how paraprofessional competence and classroom type affected the levels of teacher direction. We administered an adapted version of the Paraprofessional Needs, Knowledge & Tasks Survey and the Survey for Teachers Supervising Paraprofessionals to teachers supervising paraprofessionals in elementary schools. Structural Equation Modeling was used to examine the link between paraprofessional competence and classroom factors affecting the level of teacher supervision. Our results indicated that when teachers perceived paraprofessionals as being more skilled, they provided more supervision, and when more supervision was provided the less they thought paraprofessionals should be doing their assigned tasks. Additionally, paraprofessionals working in classrooms with more students with mild disabilities received less supervision than paraprofessionals working in classrooms with more students with moderate-to-severe disabilities. Those paraprofessionals in classrooms serving mostly children with mild disabilities were also perceived as having lower levels of skill competence than those serving in classrooms with students with more moderate-to-severe disabilities. By understanding the factors that affect teacher supervision, policy and professional development opportunities can be refined/developed to better support both supervising teachers and paraprofessionals and, in turn, improve the outcomes of children with disabilities. Copyright © 2017 Elsevier Ltd. All rights reserved.

Effect of pre-roast moisture content and post roast cooling parameters on oil migration during oil roasting of peanuts

Science.gov (United States)

Oil migration affects the quality and shelf-life of food products and consequently has an impact on overall consumer acceptance. Exchange of oil may occur during or after oil roasting of peanuts but little is known about the factors contributing to this exchange. This study examines the effect of p...

Factors Affecting Customer Retention in the Airline Industry

Directory of Open Access Journals (Sweden)

Raghda Climis

2017-01-01

Full Text Available Purpose: This study empirically investigated the factors that affect customer retention in the airline industry in North Cyprus. These factors were service quality attributes, perceived safety, customer satisfaction, loyalty reward program, relationship commitment and customer loyalty. The study also investigated four different groups for purposes of travel (business, education, vacation and family visit in the empirical model. Methodology: A descriptive approach was chosen to conduct this research. A quanhip between customer retention and the related study factors; however, not all of these relations are signifcant. The results also showed that the different purposes of travel had different influences on the variables regarding the positive and signifcant relations between them. Some independent variables had a negative effect on the dependent variables. Conclusions: This research was limited to one group and place: the students of Eastern Mediterranean University in North Cyprus. Originality: This study connected the retention, loyalty, satisfaction and service quality factors as attributes. In addition, this research was the frst to include other independent factors affecting satisfaction and loyalty in a comparison between four different groups regarding the purpose of travel in the airline industry.

Soluble vascular endothelial growth factor (VEGF) receptor-1 inhibits migration of human monocytic THP-1 cells in response to VEGF.

Science.gov (United States)

Zhu, Cansheng; Xiong, Zhaojun; Chen, Xiaohong; Lu, Zhengqi; Zhou, Guoyu; Wang, Dunjing; Bao, Jian; Hu, Xueqiang

2011-08-01

We aimed to investigate the regulation and contribution of vascular endothelial growth factor (VEGF) and sFlt-1(1-3) to human monocytic THP-1 migration. Ad-sFlt-1/FLAG, a recombinant adenovirus carrying the human sFlt-1(1-3) (the first three extracellular domains of FLT-1, the hVEGF receptor-1) gene, was constructed. L929 cells were infected with Ad-sFlt-1/FLAG and the expression of sFlt-1 was detected by immunofluorescent assay and ELISA. Corning(®) Transwell(®) Filter Inserts containing polyethylene terephthalate (PET) membranes with pore sizes of 3 μm were used as an experimental model to simulate THP-1 migration. Five VEGF concentrations (0, 0.1, 1, 10 and 100 ng/ml), four concentrations of sFlt-1(1-3)/FLAG expression supernatants (0.1, 1, 10 and 100 ng/ml), and monocyte chemoattractant protein-1 (MCP-1, 10 ng/ml) were used to test the ability of THP-1 cells to migrate through PET membranes. The sFlt-1(1-3) gene was successfully recombined into Ad-sFlt-1/FLAG. sFlt-1(1-3) was expressed in L929 cells transfected with Ad-sFlt-1/FLAG. THP-1 cell migration increased with increasing concentrations of VEGF, while cell migration decreased with increasing concentrations of sFlt1(1-3)/FLAG. sFlt1(1-3)/FLAG had no effect on MCP-1-induced cell migration. This study demonstrated that VEGF is able to elicit a migratory response in THP-1 cells, and that sFlt-1(1-3) is an effective inhibitor of THP-1 migration towards VEGF.

Collective cell migration during inflammatory response

Science.gov (United States)

Wu, Di; Stroka, Kimberly; Aranda-Espinoza, Helim

2012-02-01

Wound scratch healing assays of endothelial cell monolayers is a simple model to study collective cell migration as a function of biological signals. A signal of particular interest is the immune response, which after initial wounding in vivo causes the release of various inflammatory factors such as tumor necrosis alpha (TNF-α). TNF-α is an innate inflammatory cytokine that can induce cell growth, cell necrosis, and change cell morphology. We studied the effects of TNF-α on collective cell migration using the wound healing assays and measured several migration metrics, such as rate of scratch closure, velocities of leading edge and bulk cells, closure index, and velocity correlation functions between migrating cells. We observed that TNF-α alters all migratory metrics as a function of the size of the scratch and TNF-α content. The changes observed in migration correlate with actin reorganization upon TNF-α exposure.

The impact of forced migration on the mental health of the elderly: a scoping review.

Science.gov (United States)

Virgincar, Ashwini; Doherty, Shannon; Siriwardhana, Chesmal

2016-06-01

The worldwide elderly population fraction is increasing, with the greatest rise in developing countries. Older adults affected by conflict and forced migration mainly taking place in developing countries may be particularly vulnerable to poor mental health due to other age-specific risk factors. This review aims to explore global evidence on the effect of conflict-induced forced migration on the mental health of older adults. Seven bibliographic databases were searched. The title and abstract of 797 results were reviewed for qualitative and quantitative studies meeting inclusion and exclusion criteria. Six studies were selected for the in-depth review. Five papers assessed mental health in older adult populations displaced as refugees. One paper assessed mental health of older adults with varying immigration status. This review highlights the dearth of evidence about the impact of forced migration on the mental health of older adults. Further research is needed to explore the risk factors and processes that contribute to adverse mental health outcomes among older adult populations. This is essential to the development of interventions for this vulnerable and at-risk population, particularly in resource-poor settings.

Angiopoietin-related growth factor (AGF) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with RGD-binding integrins

International Nuclear Information System (INIS)

Zhang Yueqing; Hu Xiaobo; Tian Ruiyang; Wei Wangui; Hu Wei; Chen Xia; Han Wei; Chen Huayou; Gong Yi

2006-01-01

Angiopoietin-related growth factor (AGF) is a newly identified member of angiopoietin-related proteins (ARPs)/angiopoietin-like proteins (Angptls). AGF has been considered as a novel growth factor in accelerating cutaneous wound healing, as it is capable of stimulating keratinocytes proliferation as well as angiogenesis. But in our paper, we demonstrate that AGF stimulates keratinocytes proliferation only at high protein concentration, however, it can potently promote adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells. Furthermore, we confirm that the adhesion and migration cellular events are mediated by RGD-binding integrins, most possibly the α v -containing integrins, by in vitro inhibition assays using synthetic competitive peptides. Our results strongly suggest that AGF is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism

Personal Networks and Migration Decision: The Case of Jamaican Brain Drain

Directory of Open Access Journals (Sweden)

Rosalyn NEGRÓN

2012-05-01

Full Text Available Brain drain is the phenomena where the most educated citizens of a country migrate to countries with better opportunities. This typically affects developing countries more negatively than developed countries. Given the close proximity to the US and the high standard of education of its citizens, Jamaica tends to be particularly hard hit by this brain drain. In this paper I examine intentions to migrate among skilled and educated Jamaicans. Specifically, I explore to what extent the composition of their personal network affects their decision to migrate. The data set consists of 62 university students, roughly half of who intended to migrate. Data were collected on 40 people that they knew, including information about social support provided by their social networks. The socioeconomic data about respondents did not predict intentions to migrate. However, students at Campion College, a prestigious high school linked to upper middle class status, were significantly more likely to express an interest in migration than students from other schools. Frequency of travel abroad was negatively related to intention to migrate for those that had traveled at least once. The proportion of network members that provided informational and career advice was significantly higher for those that intended to migrate. Implications of these findings for immigration policy in Jamaica and receiving countries are discussed.

Migration and adaptation to climate change

Energy Technology Data Exchange (ETDEWEB)

Tacoli, Cecilia

2007-11-15

Climate change is having an undeniable impact on many human systems and behaviours, including population mobility. This is hardly surprising: migration is an adaptive response to changes in people's circumstances. Yet environmental factors are not the whole story. Socio-economic, political and cultural factors are also closely linked to population movement, and heavily influence vulnerability to both direct and indirect impacts of climate change. Shifts in migration patterns are a strategy of adaptation to complex transformations, and recognising and accommodating this is key in policies for sustainable development and poverty reduction in the context of growing environmental stress.

DESIGNING THE RETURN MIGRATION OF ROMANIAN STUDENTS

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Magdalena VELCIU

2017-05-01

Full Text Available Romanian youth migration is an increasing phenomenon, due to subjective and objective factors as economical reasons, professional carrer and increasingly more international competition for talent. In these circumstances, the present article aims to evaluate determinant factors that contribute to the decision of Romanian graduates to return national labour market. We sustain that young Romanians consider carefully and hardly decide their professional future. A particular attention is given to their personal reasons and motivations as well as family and friends network. For designing returning factors we present the results of a questionnaire survey, asking young pupils and students about their future educational way and personal reasons underlying the decision to study in a foreign country and taking into consideration the returning decision. As far international student migration is seen as a first step to migration for work, our work desires to fight for returning home of Romanian well-educated graduates.

Factors affecting the effects of diuresis renography

International Nuclear Information System (INIS)

Zhao Deshan

2006-01-01

Diuresis renography is one of the classic methods for diagnosing upper urinary tract obstruction in both children and adults. However, in clinical practice, the results of diuresis renography were often influenced by many factors including diuretics, timing of diuretics injection, the status of renal function and hydration, the volume and compliance of collecting system, bladder fullness and so on. It is important to consider all the factors affecting diuresis renography during performing and interpreting diuresis renography. (authors)

Macrophage migration inhibitory factor induces vascular leakage via autophagy

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Hong-Ru Chen

2015-01-01

Full Text Available Vascular leakage is an important feature of acute inflammatory shock, which currently has no effective treatment. Macrophage migration inhibitory factor (MIF is a pro-inflammatory cytokine that can induce vascular leakage and plays an important role in the pathogenesis of shock. However, the mechanism of MIF-induced vascular leakage is still unclear. In this study, using recombinant MIF (rMIF, we demonstrated that MIF induced disorganization and degradation of junction proteins and increased the permeability of human endothelial cells in vitro. Western blotting analysis showed that rMIF treatment induced LC3 conversion and p62 degradation. Inhibition of autophagy with a PI3K inhibitor (3-MA, a ROS scavenger (NAC or autophagosomal-lysosomal fusion inhibitors (bafilomycin A1 and chloroquine rescued rMIF-induced vascular leakage, suggesting that autophagy mediates MIF-induced vascular leakage. The potential involvement of other signaling pathways was also studied using different inhibitors, and the results suggested that MIF-induced vascular leakage may occur through the ERK pathway. In conclusion, we showed that MIF triggered autophagic degradation of endothelial cells, resulting in vascular leakage. Inhibition of MIF-induced autophagy may provide therapeutic targets against vascular leakage in inflammatory shock.

Personal factors affecting organizational commitment of records ...

African Journals Online (AJOL)

This study investigated personal factors affecting organizational commitment among records management personnel in the state universities in Nigeria. Simple cluster sampling with equal allocation method was used to select 180 records management personnel from the study population. A five item organizational ...

Circadian flight schedules in night-migrating birds caught on migration.

Science.gov (United States)

Coppack, Timothy; Becker, Simon F; Becker, Philipp J J

2008-12-23

Many species of migratory birds migrate in a series of solitary nocturnal flights. Between flights, they stop to rest and refuel for the next segment of their journey. The mechanism controlling this behaviour has long remained elusive. Here, we show that wild-caught migratory redstarts (Phoenicurus phoenicurus) are consistent in their flight scheduling. An advanced videographic system enabled us to determine the precise timing of flight activity in redstarts caught at a northern European stopover site during their return trip from Africa. Birds were held captive for three days in the absence of photoperiodic cues (constant dim light) and under permanent food availability. Despite the absence of external temporal cues, birds showed clear bimodal activity patterns: intense nocturnal activity alternating with diurnal foraging and resting periods. The onset of their migratory activity coincided with the time of local sunset and was individually consistent on consecutive nights. The data demonstrate that night-migrating birds are driven by autonomous circadian clocks entrained by sunset cues. This timekeeping system is probably the key factor in the overall control of nocturnal songbird migration.

Pancreatic endoplasmic reticulum kinase activation promotes medulloblastoma cell migration and invasion through induction of vascular endothelial growth factor A.

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Stephanie Jamison

Full Text Available Evidence is accumulating that activation of the pancreatic endoplasmic reticulum kinase (PERK in response to endoplasmic reticulum (ER stress adapts tumor cells to the tumor microenvironment and enhances tumor angiogenesis by inducing vascular endothelial growth factor A (VEGF-A. Recent studies suggest that VEGF-A can act directly on certain tumor cell types in an autocrine manner, via binding to VEGF receptor 2 (VEGFR2, to promote tumor cell migration and invasion. Although several reports show that PERK activation increases VEGF-A expression in medulloblastoma, the most common solid malignancy of childhood, the role that either PERK or VEGF-A plays in medulloblastoma remains elusive. In this study, we mimicked the moderate enhancement of PERK activity observed in tumor patients using a genetic approach and a pharmacologic approach, and found that moderate activation of PERK signaling facilitated medulloblastoma cell migration and invasion and increased the production of VEGF-A. Moreover, using the VEGFR2 inhibitor SU5416 and the VEGF-A neutralizing antibody to block VEGF-A/VEGFR2 signaling, our results suggested that tumor cell-derived VEGF-A promoted medulloblastoma cell migration and invasion through VEGFR2 signaling, and that both VEGF-A and VEGFR2 were required for the promoting effects of PERK activation on medulloblastoma cell migration and invasion. Thus, these findings suggest that moderate PERK activation promotes medulloblastoma cell migration and invasion through enhancement of VEGF-A/VEGFR2 signaling.

Relevant Affect Factors of Smartphone Mobile Data Traffic

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Siniša Husnjak

2016-08-01

Full Text Available Smartphones are used to access a wide range of different information and communication services and perform functions based on data transfer. A number of subscription contracts for smartphones is rapidly increasing, and the development of mobile communications network provides higher speed of data transfer. The continuous increase in the average amount of data traffic per one subscriber contract leads to an increase in the total Mobile Data Traffic (MDT, globally. This research represents a summary of factors that affect the amount of smartphone MDT. Previous literature shows only a few of the factors individually that affect the realization of smartphone MDT. The results of the research clarify the ways which influence the amount of MDT generated by a smartphone. This paper increases the awareness of the users of the methods of generating smartphone MDT. The research also allows users to specify parameters that affect the prediction of generated MDT of a smartphone.

Discrimination and distress among Afghan refugees in northern California: The moderating role of pre- and post-migration factors

Science.gov (United States)

2018-01-01

This study investigates the effect of perceived discrimination on the mental health of Afghan refugees, and secondly, tests the distress moderating effects of pre-migration traumatic experiences and post-resettlement adjustment factors. In a cross-sectional design, 259 Afghans completed surveys assessing perceived discrimination and a number of other factors using scales developed through inductive techniques. Multivariable analyses consisted of a series of hierarchical regressions testing the effect of perceived discrimination on distress, followed by a sequential analysis of moderator variables. Perceived discrimination was significantly associated with higher distress, and this relationship was stronger among those with a strong intra-ethnic identity and high pre-resettlement traumatic experiences. The expected buffering effects of civic engagement, ethnic orientation (e.g. integration), and social support were not significant. Discrimination is a significant source of stress for Afghan refugees, which may exacerbate stresses associated with other pre- and post-migration stressors. Future research is needed to tailor interventions that can help mitigate the stress associated with discrimination among this highly vulnerable group. PMID:29782531

Migration waves to the Baltic Sea region.

Science.gov (United States)

Lappalainen, T; Laitinen, V; Salmela, E; Andersen, P; Huoponen, K; Savontaus, M-L; Lahermo, P

2008-05-01

In this study, the population history of the Baltic Sea region, known to be affected by a variety of migrations and genetic barriers, was analyzed using both mitochondrial DNA and Y-chromosomal data. Over 1200 samples from Finland, Sweden, Karelia, Estonia, Setoland, Latvia and Lithuania were genotyped for 18 Y-chromosomal biallelic polymorphisms and 9 STRs, in addition to analyzing 17 coding region polymorphisms and the HVS1 region from the mtDNA. It was shown that the populations surrounding the Baltic Sea are genetically similar, which suggests that it has been an important route not only for cultural transmission but also for population migration. However, many of the migrations affecting the area from Central Europe, the Volga-Ural region and from Slavic populations have had a quantitatively different impact on the populations, and, furthermore, the effects of genetic drift have increased the differences between populations especially in the north. The possible explanations for the high frequencies of several haplogroups with an origin in the Iberian refugia (H1, U5b, I1a) are also discussed.

Frank-ter Haar syndrome protein Tks4 regulates epidermal growth factor-dependent cell migration.

Science.gov (United States)

Bögel, Gábor; Gujdár, Annamária; Geiszt, Miklós; Lányi, Árpád; Fekete, Anna; Sipeki, Szabolcs; Downward, Julian; Buday, László

2012-09-07

Mutations in the SH3PXD2B gene coding for the Tks4 protein are responsible for the autosomal recessive Frank-ter Haar syndrome. Tks4, a substrate of Src tyrosine kinase, is implicated in the regulation of podosome formation. Here, we report a novel role for Tks4 in the EGF signaling pathway. In EGF-treated cells, Tks4 is tyrosine-phosphorylated and associated with the activated EGF receptor. This association is not direct but requires the presence of Src tyrosine kinase. In addition, treatment of cells with LY294002, an inhibitor of PI 3-kinase, or mutations of the PX domain reduces tyrosine phosphorylation and membrane translocation of Tks4. Furthermore, a PX domain mutant (R43W) Tks4 carrying a reported point mutation in a Frank-ter Haar syndrome patient showed aberrant intracellular expression and reduced phosphoinositide binding. Finally, silencing of Tks4 was shown to markedly inhibit HeLa cell migration in a Boyden chamber assay in response to EGF or serum. Our results therefore reveal a new function for Tks4 in the regulation of growth factor-dependent cell migration.

Differential migration and proliferation of geometrical ensembles of cell clusters

International Nuclear Information System (INIS)

Kumar, Girish; Chen, Bo; Co, Carlos C.; Ho, Chia-Chi

2011-01-01

Differential cell migration and growth drives the organization of specific tissue forms and plays a critical role in embryonic development, tissue morphogenesis, and tumor invasion. Localized gradients of soluble factors and extracellular matrix have been shown to modulate cell migration and proliferation. Here we show that in addition to these factors, initial tissue geometry can feedback to generate differential proliferation, cell polarity, and migration patterns. We apply layer by layer polyelectrolyte assembly to confine multicellular organization and subsequently release cells to demonstrate the spatial patterns of cell migration and growth. The cell shapes, spreading areas, and cell-cell contacts are influenced strongly by the confining geometry. Cells within geometric ensembles are morphologically polarized. Symmetry breaking was observed for cells on the circular pattern and cells migrate toward the corners and in the direction parallel to the longest dimension of the geometric shapes. This migration pattern is disrupted when actomyosin based tension was inhibited. Cells near the edge or corner of geometric shapes proliferate while cells within do not. Regions of higher rate of cell migration corresponded to regions of concentrated growth. These findings demonstrate that multicellular organization can result in spatial patterns of migration and proliferation.

Patterns of gravity induced aggregate migration during casting of fluid concretes

DEFF Research Database (Denmark)

Spangenberg, Jon; Roussel, N.; Hattel, Jesper Henri

2012-01-01

In this paper, aggregate migration patterns during fluid concrete castings are studied through experiments, dimensionless approach and numerical modeling. The experimental results obtained on two beams show that gravity induced migration is primarily affecting the coarsest aggregates resulting in...

The Inuit cancer pattern--the influence of migration

DEFF Research Database (Denmark)

Boysen, T.; Friborg, J.; Andersen, Allan

2008-01-01

The Inuit cancer pattern is characterized by high frequencies of Epstein-Barr Virus (EBV)-associated carcinomas of the nasopharynx and salivary glands. The reasons are unknown, but genetic and environmental factors are believed to be involved. Using data from the well-defined Inuit population...... following migration to Denmark. The SIR was not generally influenced by duration of stay. The high risk of carcinoma of the nasopharynx and salivary glands observed in Inuit populations is maintained after migration to a low incidence area. This indicates that genetic factors or environmental factors acting...

Comparing factors of vulnerability and resilience of mountain communities affected by landslides in Eastern Nepal

Science.gov (United States)

Sudmeier-Rieux, Karen; Dubois, Jerome; Jaboyedoff, Michel

2010-05-01

This paper describes a methodology for assessing and quantifying vulnerability and resilience of mountain communities in Eastern Nepal increasingly affected by landslides and flooding. We are interested in improving our understanding of the complex interactions between land use, landslides and multiple dimensions of risk, vulnerability and resilience to better target risk management strategies. Our approach is based on assessing underlying social, ecological and physical factors that cause vulnerability and on the other hand, those resources and capacities that increase resilience. Increasing resilience to disasters is frequently used by NGOs, governments and donors as the main goal of disaster risk reduction policies and practices. If we are to increase resilience to disasters, we need better guidance and tools for defining, assessing and monitoring its parameters. To do so, we are establishing a methodology for quantifying and mapping an index of resilience to compare resilience factors between households and communities based on interdisciplinary research methods: remote sensing, GIS, qualitative and quantitative risk assessments, participatory risk mapping, household questionnaires and focus groups discussions. Our study applied this methodology to several communities in Eastern Nepal where small, frequent landslides are greatly affecting rural lives and livelihoods. These landslides are not captured by headlines or official statistics but are examples of cumulative, hidden disasters, which are impacting everyday life and rural poverty in the Himalayas. Based on experience, marginalized populations are often aware of the physical risks and the limitations of their land. However, they continue to live in dangerous places out of necessity and for the economic or infrastructure opportunities offered. We compare two communities in Nepal, both affected by landslides but with different land use, migration patterns, education levels, social networks, risk reduction

Migration to the Maya Biosphere Reserve, Guatemala: Why place matters.

Science.gov (United States)

Carr, David L

2008-01-01

Virtually all migration research examines international migration or urbanization. Yet understudied rural migrants are of critical concern for environmental conservation and rural sustainable development. Despite the fact that a relatively small number of all migrants settle remote rural frontiers, these are the agents responsible for perhaps most of the tropical deforestation on the planet. Further, rural migrants are among the most destitute people worldwide in terms of economic and human development. While a host of research has investigated deforestation resulting from frontier migration, and a modest literature has emerged on frontier development, this article explores the necessary antecedent to tropical deforestation and poverty along agricultural frontiers: out-migration from origin areas. The data come from a 2000 survey with community leaders and key informants in 16 municipios of migrant origin to the Maya Biosphere Reserve (MBR), Petén, Guatemala. A common denominator among communities of migration origin to the Petén frontier was unequal resource access, usually land. Nevertheless, the factors driving resource scarcity were widely variable. Land degradation, land consolidation, and population growth prevailed in some communities but not in others. Despite similar exposure to community and regional level push factors, most people in the sampled communities did not out-migrate, suggesting that any one or combination of factors is not necessarily sufficient for out-migration.

Ecological factors affect the level and scaling of avian BMR.

Science.gov (United States)

McNab, Brian Keith

2009-01-01

The basal rate of metabolism (BMR) in 533 species of birds, when examined with ANCOVA, principally correlates with body mass, most of the residual variation correlating with food habits, climate, habitat, a volant or flightless condition, use or not of torpor, and a highland or lowland distribution. Avian BMR also correlates with migratory habits, if climate and a montane distribution is excluded from the analysis, and with an occurrence on small islands if a flightless condition and migration are excluded. Residual variation correlates with membership in avian orders and families principally because these groups are behaviorally and ecologically distinctive. However, the distinction between passerines and other birds remains a significant correlate of avian BMR, even after six ecological factors are included, with other birds having BMRs that averaged 74% of the passerine mean. This combination of factors accounts for 97.7% of the variation in avian BMR. Yet, migratory species that belong to Anseriformes, Charadriiformes, Pelecaniformes, and Procellariiformes and breed in temperate or polar environments have mass-independent basal rates equal to those found in passerines. In contrast, penguins belong to an order of polar, aquatic birds that have basal rates lower than passerines because their flightless condition depresses basal rate. Passerines dominate temperate, terrestrial environments and the four orders of aquatic birds dominate temperate and polar aquatic environments because their high BMRs facilitate reproduction and migration. The low BMRs of tropical passerines may reflect a sedentary lifestyle as much as a life in a tropical climate. Birds have BMRs that are 30-40% greater than mammals because of the commitment of birds to an expensive and expansive form of flight.

MiR-9-5p promotes MSC migration by activating β-catenin signaling pathway.

Science.gov (United States)

Li, Xianyang; He, Lihong; Yue, Qing; Lu, Junhou; Kang, Naixin; Xu, Xiaojing; Wang, Huihui; Zhang, Huanxiang

2017-07-01

Mesenchymal stem cells (MSCs) have the potential to treat various tissue damages, but the very limited number of cells that migrate to the damaged region strongly restricts their therapeutic applications. Full understanding of mechanisms regulating MSC migration will help to improve their migration ability and therapeutic effects. Increasing evidence shows that microRNAs play important roles in the regulation of MSC migration. In the present study, we reported that miR-9-5p was upregulated in hepatocyte growth factor -treated MSCs and in MSCs with high migration ability. Overexpression of miR-9-5p promoted MSC migration, whereas inhibition of endogenous miR-9-5p decreased MSC migration. To elucidate the underlying mechanism, we screened the target genes of miR-9-5p and report for the first time that CK1α and GSK3β, two inhibitors of β-catenin signaling pathway, were direct targets of miR-9-5p in MSCs and that overexpression of miR-9-5p upregulated β-catenin signaling pathway. In line with these data, inhibition of β-catenin signaling pathway by FH535 decreased the miR-9-5p-promoted migration of MSCs, while activation of β-catenin signaling pathway by LiCl rescued the impaired migration of MSCs triggered by miR-9-5p inhibitor. Furthermore, the formation and distribution of focal adhesions as well as the reorganization of F-actin were affected by the expression of miR-9-5p. Collectively, these results demonstrate that miR-9-5p promotes MSC migration by upregulating β-catenin signaling pathway, shedding light on the optimization of MSCs for cell replacement therapy through manipulating the expression level of miR-9-5p. Copyright © 2017 the American Physiological Society.

[Migration expectations among nursing students in Mexico City].

Science.gov (United States)

Rosales-Martínez, Yetzi; Nigenda, Gustavo; Galárraga, Omar; Ruiz-Larios, José Arturo

2010-01-01

To analyze the factors associated with the expectations to migrate abroad among nursing students in Mexico City. A cross-sectional study was conducted with a non-random sample of 420 students. A logistic regression model was estimated. A total of 69% of the informants expressed their intention to move abroad, to look for employment (65%) and/or to continue their studies (26%). Of those, 50% would choose Canada as their destination, followed by Spain and the United States. The variables associated with migration expectations were: age, income, having relatives abroad, and perception of poor labor conditions and low wages in Mexico. Results are consistent with international literature. Low wages, poor labor conditions and the limited possibilities for professional development in Mexico are factors that contribute to generate migration expectations among nursing students. Additionally, optimistic perceptions about the job market and the labor demand in more developed countries heighten expectations to migrate.

Myocardial Expression of Macrophage Migration Inhibitory Factor in Patients with Heart Failure

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Julia Pohl

2017-10-01

Full Text Available Macrophage migration inhibitory factor (MIF is a pleiotropic inflammatory protein and contributes to several different inflammatory and ischemic/hypoxic diseases. MIF was shown to be cardioprotective in experimental myocardial ischemia/reperfusion injury and its expression is regulated by the transcription factor hypoxia-inducible factor (HIF-1α. We here report on MIF expression in the failing human heart and assess myocardial MIF in different types of cardiomyopathy. Myocardial tissue samples from n = 30 patients were analyzed by quantitative Real-Time PCR. MIF and HIF-1α mRNA expression was analyzed in myocardial samples from patients with ischemic (ICM and non-ischemic cardiomyopathy (NICM and from patients after heart transplantation (HTX. MIF expression was elevated in myocardial samples from patients with ICM compared to NICM. Transplanted hearts showed lower MIF levels compared to hearts from patients with ICM. Expression of HIF-1α was analyzed and was shown to be significantly increased in ICM patients compared to patients with NICM. MIF and HIF-1α mRNA is expressed in the human heart. MIF and HIF-1α expression depends on the underlying type of cardiomyopathy. Patients with ICM show increased myocardial MIF and HIF-1α expression.

Influence of speciation on the geospheric migration of radionuclides

International Nuclear Information System (INIS)

Hadermann, J.; Schweingruber, M.

1982-01-01

For geosphere transport calculations in safety analyses of waste repositories it is generally assumed that the retardation of a migrating radionuclide is characterized by a single retention factor. However, in groundwater, radionuclides exist in various chemical forms with strongly differing sorption properties. We consider the effect of pseudo first order chemical reactions in liquid phase on migration. Conditions are derived under which local equilibrium in liquid phase is well fulfilled and migration is governed by a single effective retention factor. It is argued that in geosphere transport, equilibrium is likely to exist even when laboratory measurements show chromatographic separations. (author)

Single-tooth replacement: factors affecting different prosthetic treatment modalities

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Al-Quran Firas A

2011-12-01

Full Text Available Abstract Background The choice between several treatment options for replacing a single missing tooth is influenced by clinical, dentist- and patient-immanent factors. This study aimed to determine the patient factors that would affect the treatment decision to replace a single missing tooth and to assess the satisfaction with several options. Method 200 volunteers involved (121 females and 79 males divided into four groups, Group A: consisted of patients with conventional fixed partial dentures or patients with resin bonded fixed partial dentures. Group B: consisted of patients who received removable partial dentures while Group C: consisted of patients who received a single implant supported crown, and a control group D: consisted of patients who received no treatment. Data were collected using a questionnaire. Results The highest percentage of males within groups (58% was within the removable prostheses category. The majority of the subjects in the study reported that the main reason for replacing a missing tooth was for esthetic and function. Most important factor affecting the choice between treatment modalities was damaging the neighboring teeth. Pain, post operative sensitivity and dental phobia were important factors in choosing the prosthesis type and affected the control group patients not to have any treatment. The highest satisfaction percentage among groups studied was recorded for dental implants then FPD groups, while the least percentage were in both the control and RPD groups, for all aspects of function, esthetic and speech efficiency. Conclusions The final choice between FPD, RPD and implant depended on several factors which affected the decision making; among these is cost and patients' awareness of the different treatment options.

Wind conditions and geography shape the first outbound migration of juvenile honey buzzards and their distribution across sub-Saharan Africa.

Science.gov (United States)

Vansteelant, W M G; Kekkonen, J; Byholm, P

2017-05-31

Contemporary tracking studies reveal that low migratory connectivity between breeding and non-breeding ranges is common in migrant landbirds. It is unclear, however, how internal factors and early-life experiences of individual migrants shape the development of their migration routes and concomitant population-level non-breeding distributions. Stochastic wind conditions and geography may determine whether and where migrants end up by the end of their journey. We tested this hypothesis by satellite-tagging 31 fledgling honey buzzards Pernis apivorus from southern Finland and used a global atmospheric reanalysis model to estimate the wind conditions they encountered on their first outbound migration. Migration routes diverged rapidly upon departure and the birds eventually spread out across 3340 km of longitude. Using linear regression models, we show that the birds' longitudinal speeds were strongly affected by zonal wind speed, and negatively affected by latitudinal wind, with significant but minor differences between individuals. Eventually, 49% of variability in the birds' total longitudinal displacements was accounted for by wind conditions on migration. Some birds circumvented the Baltic Sea via Scandinavia or engaged in unusual downwind movements over the Mediterranean, which also affected the longitude at which these individuals arrived in sub-Saharan Africa. To understand why adult migrants use the migration routes and non-breeding sites they use, we must take into account the way in which wind conditions moulded their very first journeys. Our results present some of the first evidence into the mechanisms through which low migratory connectivity emerges. © 2017 The Authors.

Wind conditions and geography shape the first outbound migration of juvenile honey buzzards and their distribution across sub-Saharan Africa

Science.gov (United States)

Kekkonen, J.; Byholm, P.

2017-01-01

Contemporary tracking studies reveal that low migratory connectivity between breeding and non-breeding ranges is common in migrant landbirds. It is unclear, however, how internal factors and early-life experiences of individual migrants shape the development of their migration routes and concomitant population-level non-breeding distributions. Stochastic wind conditions and geography may determine whether and where migrants end up by the end of their journey. We tested this hypothesis by satellite-tagging 31 fledgling honey buzzards Pernis apivorus from southern Finland and used a global atmospheric reanalysis model to estimate the wind conditions they encountered on their first outbound migration. Migration routes diverged rapidly upon departure and the birds eventually spread out across 3340 km of longitude. Using linear regression models, we show that the birds' longitudinal speeds were strongly affected by zonal wind speed, and negatively affected by latitudinal wind, with significant but minor differences between individuals. Eventually, 49% of variability in the birds' total longitudinal displacements was accounted for by wind conditions on migration. Some birds circumvented the Baltic Sea via Scandinavia or engaged in unusual downwind movements over the Mediterranean, which also affected the longitude at which these individuals arrived in sub-Saharan Africa. To understand why adult migrants use the migration routes and non-breeding sites they use, we must take into account the way in which wind conditions moulded their very first journeys. Our results present some of the first evidence into the mechanisms through which low migratory connectivity emerges. PMID:28539514

Socio-demographic and clinical factors affecting adherence to ...

African Journals Online (AJOL)

Socio-demographic and clinical factors affecting adherence to antihypertensive medications and blood pressure control among patients attending the family practice clinic in a tertiary hospital in northern Nigeria.

Security and skills: the two key issues in health worker migration

Directory of Open Access Journals (Sweden)

Posy Bidwell

2014-07-01

Full Text Available Background: Migration of health workers from Africa continues to undermine the universal provision of quality health care. South Africa is an epicentre for migration – it exports more health workers to high-income countries than any other African country and imports health workers from its lower-income neighbours to fill the gap. Although an inter-governmental agreement in 2003 reduced the very high numbers migrating from South Africa to the United Kingdom, migration continues to other high-income English-speaking countries and few workers seem to return although the financial incentive to work abroad has lessened. A deeper understanding of reasons for migration from South Africa and post-migration experiences is therefore needed to underpin policy which is developed in order to improve retention within source countries and encourage return. Methods: Semi-structured interviews were conducted with 16 South African doctors and nurses who had migrated to the United Kingdom. Interviews explored factors influencing the decision to migrate and post-migration experiences. Results: Salary, career progression, and poor working conditions were not major push factors for migration. Many health workers reported that they had previously overcome these issues within the South African healthcare system by migrating to the private sector. Overwhelmingly, the major push factors were insecurity, high levels of crime, and racial tension. Although the wish to work and train in what was perceived to be a first-class care system was a pull factor to migrate to the United Kingdom, many were disappointed by the experience. Instead of obtaining new skills, many (particularly nurses felt they had become ‘de-skilled’. Many also felt that working conditions and opportunities for them in the UK National Health Service (NHS compared unfavourably with the private sector in South Africa. Conclusions: Migration from South Africa seems unlikely to diminish until the major

Security and skills: the two key issues in health worker migration.

Science.gov (United States)

Bidwell, Posy; Laxmikanth, Pallavi; Blacklock, Claire; Hayward, Gail; Willcox, Merlin; Peersman, Wim; Moosa, Shabir; Mant, David

2014-01-01

Migration of health workers from Africa continues to undermine the universal provision of quality health care. South Africa is an epicentre for migration--it exports more health workers to high-income countries than any other African country and imports health workers from its lower-income neighbours to fill the gap. Although an inter-governmental agreement in 2003 reduced the very high numbers migrating from South Africa to the United Kingdom, migration continues to other high-income English-speaking countries and few workers seem to return although the financial incentive to work abroad has lessened. A deeper understanding of reasons for migration from South Africa and post-migration experiences is therefore needed to underpin policy which is developed in order to improve retention within source countries and encourage return. Semi-structured interviews were conducted with 16 South African doctors and nurses who had migrated to the United Kingdom. Interviews explored factors influencing the decision to migrate and post-migration experiences. Salary, career progression, and poor working conditions were not major push factors for migration. Many health workers reported that they had previously overcome these issues within the South African healthcare system by migrating to the private sector. Overwhelmingly, the major push factors were insecurity, high levels of crime, and racial tension. Although the wish to work and train in what was perceived to be a first-class care system was a pull factor to migrate to the United Kingdom, many were disappointed by the experience. Instead of obtaining new skills, many (particularly nurses) felt they had become 'de-skilled'. Many also felt that working conditions and opportunities for them in the UK National Health Service (NHS) compared unfavourably with the private sector in South Africa. Migration from South Africa seems unlikely to diminish until the major concerns over security, crime, and racial tensions are resolved

The Conditions of the Environment as Factors Affecting the Social and Political Stability of Populations

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Fausto Pedrazzini

2010-10-01

Full Text Available In this review article, the different conditions of the environment which could affect the well-being of the populations living on it are taken into consideration and analysed. A specific attention is paid to the phenomenon of water reduction, land degradation and consequent desertification. Such a phenomenon is particularly worrying in selected regions of the world (the Mediterranean Region and Central Asia in which a combination of several factors including climate variations, pressure of populations and increased competition for the available resources have a direct consequence on the economical, social and political conditions of the population. In addition, migrations could also take place, increasing the instability of entire regions. A proper management of water resources and the preservation of land and soil resources are essential requisites to counteract the mentioned adverse effects. Such a management is frequently a transboundary concern since it might involve different regions and countries; this is an additional reason for debating the environment degradation issues at the international level and for increasing the awareness of the civil society, the policy makers and governments.

Economic Analysis of Factors Affecting Technical Efficiency of ...

African Journals Online (AJOL)

Economic Analysis of Factors Affecting Technical Efficiency of Smallholders ... socio-economic characteristics which influence technical efficiency in maize production. ... Ministry of Agriculture and livestock, records, books, reports and internet.

Lutein Inhibits the Migration of Retinal Pigment Epithelial Cells via Cytosolic and Mitochondrial Akt Pathways (Lutein Inhibits RPE Cells Migration

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Ching-Chieh Su

2014-08-01

Full Text Available During the course of proliferative vitreoretinopathy (PVR, the retinal pigment epithelium (RPE cells will de-differentiate, proliferate, and migrate onto the surfaces of the sensory retina. Several studies have shown that platelet-derived growth factor (PDGF can induce migration of RPE cells via an Akt-related pathway. In this study, the effect of lutein on PDGF-BB-induced RPE cells migration was examined using transwell migration assays and Western blot analyses. We found that both phosphorylation of Akt and mitochondrial translocation of Akt in RPE cells induced by PDGF-BB stimulation were suppressed by lutein. Furthermore, the increased migration observed in RPE cells with overexpressed mitochondrial Akt could also be suppressed by lutein. Our results demonstrate that lutein can inhibit PDGF-BB induced RPE cells migration through the inhibition of both cytoplasmic and mitochondrial Akt activation.

Influential Factors Affecting Materials Management in Construction Projects

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Jusoh Zairra Mat

2017-12-01

Full Text Available Construction projects are more often than not plagued by poor performances such as delays, cost overrun, low productivity, construction wastes and compromised quality. Amongst the critical contributory factors of poor project performances, is the ineffectiveness of materials management occurring in the construction sites. Indeed, materials management is a very important component for construction projects. However, there are only limited numbers of research available regarding this topic. Thus, this research focuses its study on materials management, specifically in identifying the influential factors that affect materials management in the construction project activities. Literatures from books, journal articles and conference papers related to poor project performances and materials management have been reviewed. Consequently, this study sorted the salient influential factors and categorized them based on their specific group. Out of 47 factors identified, they are classified into 8 groups. They are (1 site condition; (2 planning and handling on site; (3 management; (4 materials; (5 supplier and manufacturer default; (6 transportation; (7 contractual; and (8 governmental interferences. In conclusion, this study contends that by identifying the influential factors affecting materials management, it will help construction players to avoid the occurrence of those factors and will minimize the negative impacts on the overall performance of construction projects. Hence, the handling-over of project will be according to schedule and not delayed by materials mismanagement.

Fitness consequences of timing of migration and breeding in cormorants.

Directory of Open Access Journals (Sweden)

Phillip Gienapp

Full Text Available In most bird species timing of breeding affects reproductive success whereby early breeding is favoured. In migratory species migration time, especially arrival at the breeding grounds, and breeding time are expected to be correlated. Consequently, migration time should also have fitness consequences. However, in contrast to breeding time, evidence for fitness consequences of migration time is much more limited. Climate change has been shown to negatively affect the synchrony between trophic levels thereby leading to directional selection on timing but again direct evidence in avian migration time is scarce. We here analysed fitness consequences of migration and breeding time in great cormorants and tested whether climate change has led to increased selection on timing using a long-term data set from a breeding colony on the island of Vorsø (Denmark. Reproductive success, measured as number of fledglings, correlated with breeding time and arrival time at the colony and declined during the season. This seasonal decline became steeper during the study period for both migration and breeding time and was positively correlated to winter/spring climate, i.e. selection was stronger after warmer winters/springs. However, the increasing selection pressure on timing seems to be unrelated to climate change as the climatic variables that were related to selection strength did not increase during the study period. There is indirect evidence that phenology or abundances of preferred prey species have changed which could have altered selection on timing of migration and breeding.

A Customizable Chamber for Measuring Cell Migration.

Science.gov (United States)

Chowdhury, Aniqa N; Vo, Huu Tri; Olang, Sharon; Mappus, Elliott; Peterson, Brian; Hlavac, Nora; Harvey, Tyler; Dean, Delphine

2017-03-12

Cell migration is a vital part of immune responses, growth, and wound healing. Cell migration is a complex process that involves interactions between cells, the extracellular matrix, and soluble and non-soluble chemical factors (e.g., chemoattractants). Standard methods for measuring the migration of cells, such as the Boyden chamber assay, work by counting cells on either side of a divider. These techniques are easy to use; however, they offer little geometric modification for different applications. In contrast, microfluidic devices can be used to observe cell migration with customizable concentration gradients of soluble factors 1 , 2 . However, methods for making microfluidics based assays can be difficult to learn. Here, we describe an easy method for creating cell culture chambers to measure cell migration in response to chemical concentration gradients. Our cell migration chamber method can create different linear concentration gradients in order to study cell migration for a variety of applications. This method is relatively easy to use and is typically performed by undergraduate students. The microchannel chamber was created by placing an acrylic insert in the shape of the final microchannel chamber well into a Petri dish. After this, poly(dimethylsiloxane) (PDMS) was poured on top of the insert. The PDMS was allowed to harden and then the insert was removed. This allowed for the creation of wells in any desired shape or size. Cells may be subsequently added to the microchannel chamber, and soluble agents can be added to one of the wells by soaking an agarose block in the desired agent. The agarose block is added to one of the wells, and time-lapse images can be taken of the microchannel chamber in order to quantify cell migration. Variations to this method can be made for a given application, making this method highly customizable.

Development of migration prediction system (MIGSTEM) for cationic species of radionuclides through soil layers

International Nuclear Information System (INIS)

Ohnuki, Toshihiko; Takebe, Shinichi; Yamamoto, Tadatoshi

1989-01-01

The migration prediction system (MIGSTEM) has been developed for estimating the migration of cationic species of radionuclides through soil layers systematically. The MIGSTEM consists of the migration experiments, the one-dimensional fitting code (inverse analysis code) for determining retardation factor and dispersivity (migration factors) and the three-dimensional differential code (prediction code) for estimating the migration of the radionuclides. The migration experiments are carried out for obtaining the concentration profiles of the radionuclides in unsaturated and saturated soil layers. Using the inverse analysis code, the migration factors are obtained at one time by fitting the concentration profiles calculated to those observed. The prediction code can give the contours of concentration and the one-dimensional concentration profiles at selected time, as well as the changing in the concentration at a selected position with time. The validity of the MIGSTEM was obtained by the benchmark test on the prediction and inverse analysis codes. The MIGSTEM was applied to estimate the migration of Sr 2+ through the sandy soil. (author)

CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1α

International Nuclear Information System (INIS)

Esencay, Mine; Sarfraz, Yasmeen; Zagzag, David

2013-01-01

Glioblastomas, the most common and malignant brain tumors of the central nervous system, exhibit high invasive capacity, which hinders effective therapy. Therefore, intense efforts aimed at improved therapeutics are ongoing to delineate the molecular mechanisms governing glioma cell migration and invasion. In order to perform the studies, we employed optimal cell culture methods and hypoxic conditions, lentivirus-mediated knockdown of protein expression, Western Blot analysis, migration assays and immunoprecipitation. We determined statistical significance by unpaired t-test. In this report, we show that U87MG, LN229 and LN308 glioma cells express CXCR7 and that exposure to hypoxia upregulates CXCR7 protein expression in these cell lines. CXCR7-expressing U87MG, LN229 and LN308 glioma cells migrated towards stromal-derived factor (SDF)-1α/CXCL12 in hypoxic conditions in the Boyden chamber assays. While shRNA-mediated knockdown of CXCR7 expression did not affect the migration of any of the three cell lines in normoxic conditions, we observed a reduction in the migration of LN229 and LN308, but not U87MG, glioma cells towards SDF-1α in hypoxic conditions. In addition, knockdown of CXCR7 expression in LN229 and LN308 glioma cells decreased levels of SDF-1α-induced phosphorylation of ERK1/2 and Akt. Inhibiting CXCR4 in LN229 and LN308 glioma cells that were knocked down for CXCR7 did not further reduce migration towards SDF-1α in hypoxic conditions and did not affect the levels of phosphorylated ERK1/2 and Akt. Analysis of immunoprecipitated CXCR4 from LN229 and LN308 glioma cells revealed co-precipitated CXCR7. Taken together, our findings indicate that both CXCR4 and CXCR7 mediate glioma cell migration towards SDF-1α in hypoxic conditions and support the development of therapeutic agents targeting these receptors

Skilled migration and health outcomes in developing countries.

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Uprety, Dambar

2018-04-30

Many studies have found that health outcomes decline when health professionals leave the country, but do such results remain consistent in gender- and income-disaggregated skilled migration? To help uncover explanations for such a pro-migration nature of health outcomes, the present study revisits this topic but allows for associations of skilled migration with mortality and life expectancy to differ between male and female, and between low- and high-income countries. Using a panel of 133 developing countries as source and 20 OECD countries as destination from 1980 to 2010 allowing the coefficient on emigration across different education levels to differ, the study finds the negative effect of high-skilled emigration on health outcomes. Such effect is more pronounced for high-skilled female migration than those for male and for low-income countries than for middle-and high-income countries. Results also show that such adverse effect is larger for African countries than non-African ones. However, the low-skilled migration appears to be insignificant to affect health outcomes in developing countries. Thus, skilled migration is detrimental to longevity in developing countries but unskilled migration is not.

Men’s Migration and Women’s Fertility in Rural Mozambique

OpenAIRE

Agadjanian, Victor; Yabiku, Scott T.; Cau, Boaventura

2011-01-01

Labor migration profoundly affects households throughout rural Africa. This study looks at how men’s labor migration influences marital fertility in a context where such migration has been massive while its economic returns are increasingly uncertain. Using data from a survey of married women in southern Mozambique, we start with an event-history analysis of birth rates among women married to migrants and those married to nonmigrants. The model detects a lower birth rate among migrants’ wives...

Empirical Analysis on Factors Affecting User Behavior in Social Commerce

Directory of Open Access Journals (Sweden)

Xu Jiayi

2017-02-01

Full Text Available [Purpose/significance] This paper aims to discover the factors affecting user behavior in the derivative situation of e-commerce, social commerce, and explore the sustainable development and related marketing advice of it. [Method/process］This paper put forward a theoretical model of factors affecting user behavior in social commerce by integrating emotional state impact into the Stimulus-Organism-Response (S-O-R framework. 277 valid samples were collected by questionnaires and PLS. [Result/conclusion］The results show that information quality and tie strength significantly affect user emotional states, while emotional states positively affect user behavior. In addition, graphic features of business information have indirect effects on user emotional states, while it has direct effect on purchase intention.

Factors affecting academic leadership in dermatology.

Science.gov (United States)

Martires, Kathryn J; Aquino, Lisa L; Wu, Jashin J

2015-02-01

Although prior studies have examined methods by which to recruit and retain academic dermatologists, few have examined factors that are important for developing academic leaders in dermatology. This study sought to examine characteristics of dermatology residency programs that affect the odds of producing department or division chairs/chiefs and program directors (PDs). Data regarding program size, faculty, grants, alumni residency program attended, lectures, and publications for all accredited US dermatology residency programs were collected. Of the 103 programs examined, 46% had graduated at least 1 chair/chief, and 53% had graduated at least 1 PD. Results emphasize that faculty guidance and research may represent modifiable factors by which a dermatology residency program can increase its graduation of academic leaders.

The accretion of migrating giant planets

Science.gov (United States)

Dürmann, Christoph; Kley, Wilhelm

2017-02-01

Aims: Most studies concerning the growth and evolution of massive planets focus either on their accretion or their migration only. In this work we study both processes concurrently to investigate how they might mutually affect one another. Methods: We modeled a two-dimensional disk with a steady accretion flow onto the central star and embedded a Jupiter mass planet at 5.2 au. The disk is locally isothermal and viscosity is modeled using a constant α. The planet is held on a fixed orbit for a few hundred orbits to allow the disk to adapt and carve a gap. After this period, the planet is released and free to move according to the gravitational interaction with the gas disk. The mass accretion onto the planet is modeled by removing a fraction of gas from the inner Hill sphere, and the removed mass and momentum can be added to the planet. Results: Our results show that a fast migrating planet is able to accrete more gas than a slower migrating planet. Utilizing a tracer fluid we analyzed the origin of the accreted gas originating predominantly from the inner disk for a fast migrating planet. In the case of slower migration, the fraction of gas from the outer disk increases. We also found that even for very high accretion rates, in some cases gas crosses the planetary gap from the inner to the outer disk. Our simulations show that the crossing of gas changes during the migration process as the migration rate slows down. Therefore, classical type II migration where the planet migrates with the viscous drift rate and no gas crosses the gap is no general process but may only occur for special parameters and at a certain time during the orbital evolution of the planet.

A study of affecting factors on the degree of university students ...

African Journals Online (AJOL)

There are different factors which affect the way people select and continue their attitudes towards products of certain brands. The main objective of the present study was investigating factors affecting the degree of University students' loyalty to Nike brand. This research is functional in regard with objective and ...

Mental health of newly arrived Burmese refugees in Australia: contributions of pre-migration and post-migration experience.

Science.gov (United States)

Schweitzer, Robert D; Brough, Mark; Vromans, Lyn; Asic-Kobe, Mary

2011-04-01

This study documents the mental health status of people from Burmese refugee backgrounds recently arrived in Australia, then examines the contributions of gender, pre-migration and post-migration factors in predicting mental health. Structured interviews, including a demographic questionnaire, the Harvard Trauma Questionnaire, the Post-migration Living Difficulties Checklist and Hopkins Symptom Checklist assessed pre-migration trauma, post-migration living difficulties, depression, anxiety, somatization and traumatization symptoms in a sample of 70 adults across five Burmese ethnic groups. Substantial proportions of participants reported psychological distress in symptomatic ranges including: post-traumatic stress disorder (9%), anxiety (20%) and depression (36%), as well as significant symptoms of somatization (37%). Participants reported multiple and severe pre-migration traumas. Post-migration living difficulties of greatest concern included communication problems and worry about family not in Australia. Gender did not predict mental health. Level of exposure to traumatic events and post-migration living difficulties each made unique and relatively equal contributions to traumatization symptoms. Post-migration living difficulties made unique contributions to depression, anxiety and somatization symptoms. While exposure to traumatic events impacted on participants' mental well-being, post-migration living difficulties had greater salience in predicting mental health outcomes of people from Burmese refugee backgrounds. Reported rates of post-traumatic stress disorder symptoms were consistent with a large review of adults across seven western countries. High levels of somatization point to a nuanced expression of distress. Findings have implications for service provision in terms of implementing appropriate interventions to effectively meet the needs of this newly arrived group in Australia.

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