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Sample records for factor xii fxii

  1. Selective depletion of plasma prekallikrein or coagulation factor XII inhibits thrombosis in mice without increased risk of bleeding.

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    Revenko, Alexey S; Gao, Dacao; Crosby, Jeff R; Bhattacharjee, Gourab; Zhao, Chenguang; May, Chris; Gailani, David; Monia, Brett P; MacLeod, A Robert

    2011-11-10

    Recent studies indicate that the plasma contact system plays an important role in thrombosis, despite being dispensable for hemostasis. For example, mice deficient in coagulation factor XII (fXII) are protected from arterial thrombosis and cerebral ischemia-reperfusion injury. We demonstrate that selective reduction of prekallikrein (PKK), another member of the contact system, using antisense oligonucleotide (ASO) technology results in an antithrombotic phenotype in mice. The effects of PKK deficiency were compared with those of fXII deficiency produced by specific ASO-mediated reduction of fXII. Mice with reduced PKK had ∼ 3-fold higher plasma levels of fXII, and reduced levels of fXIIa-serpin complexes, consistent with fXII being a substrate for activated PKK in vivo. PKK or fXII deficiency reduced thrombus formation in both arterial and venous thrombosis models, without an apparent effect on hemostasis. The amount of reduction of PKK and fXII required to produce an antithrombotic effect differed between venous and arterial models, suggesting that these factors may regulate thrombus formation by distinct mechanisms. Our results support the concept that fXII and PKK play important and perhaps nonredundant roles in pathogenic thrombus propagation, and highlight a novel, specific and safe pharmaceutical approach to target these contact system proteases.

  2. Genotyping analysis for the 46 C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss.

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    Eriko Asano

    Full Text Available BACKGROUND: Established causes of recurrent pregnancy loss (RPL include antiphospholipid syndrome, uterine anomalies, parental chromosomal abnormalities, particularly translocations and abnormal embryonic karyotype. A systematic review concluded that coagulation factor XII (FXII deficiency was associated with RPL. However, it could not be established whether the 46 C/T SNP of FXII or low activity of FXII was a risk factor for RPL, because of the small sample size. METHODS AND FINDINGS: We conducted a cross-sectional and cohort study in 279 patients with two or more unexplained consecutive pregnancy losses and 100 fertile women. The association between the lupus anticoagulant (LA activity and FXII activity was examined. The frequency of the CC, CT and TT genotypes and the FXII activity were also compared between the patients and controls. Subsequent miscarriage rates among the CC, CT, TT genotypes and according to the FXII activity was examined. LA was associated with reduced FXII activity. The CT, but not the TT, genotype was confirmed to be a risk factor for RPL in the cross-sectional study using multivariate logistic regression analysis (OR, 2.8; 95% CI, 1.37-5.85. The plasma FXII activity in the patients was similar to that in the controls. Neither low FXII activity nor the CT genotype predicted the subsequent pregnancy outcome in the cohort study. On the other hand, and intermediate FXII activity level of 85-101% was predictive of subsequent miscarriage. CONCLUSIONS: Low FXII activity was not associated with RPL. The FXII gene was found to be one of the significant susceptibility genes for RPL, similar to the FV Leiden mutation. However, the clinical influence of the CT genotype might be relatively small, because the presence/absence of this genotype did not have any predictive value for the subsequent pregnancy outcome. This was the first study indicating the influence of FXII 46C/T on further pregnancy outcomes.

  3. Plasmin is a natural trigger for bradykinin production in patients with hereditary angioedema with factor XII mutations

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    de Maat, Steven; Björkqvist, Jenny; Suffritti, Chiara; Wiesenekker, Chantal P.; Nagtegaal, Willem; Koekman, Arnold; van Dooremalen, Sanne; Pasterkamp, Gerard; de Groot, Philip G.; Cicardi, Marco; Renné, Thomas; Maas, Coen

    2016-01-01

    BACKGROUND: Patients with angioedema experience unpredictable attacks of tissue swelling in which bradykinin is implicated. Several distinct mutations in Factor XII (FXII) are associated with hereditary angioedema (HAE) in the presence of normal C1 esterase inhibitor activity (FXII-HAE). The underly

  4. Factor XII-Driven Inflammatory Reactions with Implications for Anaphylaxis

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    Lysann Bender

    2017-09-01

    Full Text Available Anaphylaxis is a life-threatening allergic reaction. It is triggered by the release of pro-inflammatory cytokines and mediators from mast cells and basophils in response to immunologic or non-immunologic mechanisms. Mediators that are released upon mast cell activation include the highly sulfated polysaccharide and inorganic polymer heparin and polyphosphate (polyP, respectively. Heparin and polyP supply a negative surface for factor XII (FXII activation, a serine protease that drives contact system-mediated coagulation and inflammation. Activation of the FXII substrate plasma kallikrein leads to further activation of zymogen FXII and triggers the pro-inflammatory kallikrein–kinin system that results in the release of the mediator bradykinin (BK. The severity of anaphylaxis is correlated with the intensity of contact system activation, the magnitude of mast cell activation, and BK formation. The main inhibitor of the complement system, C1 esterase inhibitor, potently interferes with FXII activity, indicating a meaningful cross-link between complement and kallikrein–kinin systems. Deficiency in a functional C1 esterase inhibitor leads to a severe swelling disorder called hereditary angioedema (HAE. The significance of FXII in these disorders highlights the importance of studying how these processes are integrated and can be therapeutically targeted. In this review, we focus on how FXII integrates with inflammation and the complement system to cause anaphylaxis and HAE as well as highlight current diagnosis and treatments of BK-related diseases.

  5. Defective glycosylation of coagulation factor XII underlies hereditary angioedema type III.

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    Björkqvist, Jenny; de Maat, Steven; Lewandrowski, Urs; Di Gennaro, Antonio; Oschatz, Chris; Schönig, Kai; Nöthen, Markus M; Drouet, Christian; Braley, Hal; Nolte, Marc W; Sickmann, Albert; Panousis, Con; Maas, Coen; Renné, Thomas

    2015-08-03

    Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is associated with point mutations in the gene encoding the plasma protease factor XII (FXII). Here, we demonstrate that HAEIII-associated mutant FXII, derived either from HAEIII patients or recombinantly produced, is defective in mucin-type Thr309-linked glycosylation. Loss of glycosylation led to increased contact-mediated autoactivation of zymogen FXII, resulting in excessive activation of the bradykinin-forming kallikrein-kinin pathway. In contrast, both FXII-driven coagulation and the ability of C1-esterase inhibitor to bind and inhibit activated FXII were not affected by the mutation. Intravital laser-scanning microscopy revealed that, compared with control animals, both F12-/- mice reconstituted with recombinant mutant forms of FXII and humanized HAEIII mouse models with inducible liver-specific expression of Thr309Lys-mutated FXII exhibited increased contact-driven microvascular leakage. An FXII-neutralizing antibody abolished bradykinin generation in HAEIII patient plasma and blunted edema in HAEIII mice. Together, the results of this study characterize the mechanism of HAEIII and establish FXII inhibition as a potential therapeutic strategy to interfere with excessive vascular leakage in HAEIII and potentially alleviate edema due to other causes.

  6. Comparable levels of activity and antigen in factor XII deficiency: a study of 21 homozygotes and 58 heterozygotes.

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    Girolami, A; Gavasso, S; Pacquola, E; Cabrio, L; Lombardi, A M; Girolami, B

    2005-07-01

    Results of coagulation studies on 21 homozygote patients with factor XII (FXII) deficiency revealed that all of them had no cross-reacting material (CRM) in their plasma. The 58 heterozygotes had in every instance an antigen level comparable to that of clotting activity namely, approximately 50% of normal. An analysis of all pertinent literature also showed that the presence of CRM is very rare in FXII deficiency. CRM is present in approximately 5% of homozygote patients. More precisely, seven of 145 patients. Only in one case, the antigen level was normal (FXII Washington). This prevalence appears lower than that observed for another contact phase factor (prekallikrein). The significance of blood abnormal forms of FXII has not been completely clarified yet. Their study appears useful in the attempt of clarifying the structure-function relation of factor XII.

  7. Factor XII: a novel target for safe prevention of thrombosis and inflammation.

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    Kenne, E; Nickel, K F; Long, A T; Fuchs, T A; Stavrou, E X; Stahl, F R; Renné, T

    2015-12-01

    Plasma protein factor XII (FXII) activates the procoagulant and proinflammatory contact system that drives both the kallikrein-kinin system and the intrinsic pathway of coagulation. When zymogen FXII comes into contact with negatively charged surfaces, it auto-activates to the serine proteaseactivated FXII (FXIIa). Recently, various in vivo activators of FXII have been identified including heparin, misfolded protein aggregates, polyphosphate and nucleic acids. Murine models have established a central role of FXII in arterial and venous thrombosis. Despite its central function in thrombosis, deficiency in FXII does not impair haemostasis in animals and humans. In a preclinical cardiopulmonary bypass system in large animals, the FXIIa-blocking antibody 3F7 prevented thrombosis; however, in contrast to traditional anticoagulants, bleeding was not increased. In addition to its function in thrombosis, FXIIa initiates formation of the inflammatory mediator bradykinin. This mediator increases vascular leak, causes vasodilation, and induces chemotaxis with implications for septic, anaphylactic and allergic disease states. Therefore, targeting FXIIa appears to be a promising strategy for thromboprotection without associated bleeding risks but with anti-inflammatory properties.

  8. A Comparison of Blood Factor XII Autoactivation in Buffer, Protein Cocktail, Serum, and Plasma Solutions

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    Golas, Avantika; Yeh, Chyi-Huey Josh; Pitakjakpipop, Harit; Siedlecki, Christopher A.; Vogler, Erwin A.

    2012-01-01

    Activation of blood plasma coagulation in vitro by contact with material surfaces is demonstrably dependent on plasma-volume-to-activator-surface-area ratio. The only plausible explanation consistent with current understanding of coagulation-cascade biochemistry is that procoagulant stimulus arising from the activation complex of the intrinsic pathway is dependent on activator surface area. And yet, it is herein shown that activation of the blood zymogen factor XII (Hageman factor, FXII) dissolved in buffer, protein cocktail, heat-denatured serum, and FXI deficient plasma does not exhibit activator surface-area dependence. Instead, a highly-variable burst of procoagulant-enzyme yield is measured that exhibits no measurable kinetics, sensitivity to mixing, or solution-temperature dependence. Thus, FXII activation in both buffer and protein-containing solutions does not exhibit characteristics of a biochemical reaction but rather appears to be a “mechanochemical” reaction induced by FXII molecule interactions with hydrophilic activator particles that do not formally adsorb blood proteins from solution. Results of this study strongly suggest that activator surface-area dependence observed in contact activation of plasma coagulation does not solely arise at the FXII activation step of the intrinsic pathway. PMID:23117212

  9. Depletion of coagulation factor XII ameliorates brain pathology and cognitive impairment in Alzheimer disease mice.

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    Chen, Zu-Lin; Revenko, Alexey S; Singh, Pradeep; MacLeod, A Robert; Norris, Erin H; Strickland, Sidney

    2017-05-04

    Vascular abnormalities and inflammation are found in many Alzheimer disease (AD) patients, but whether these changes play a causative role in AD is not clear. The factor XII (FXII) -initiated contact system can trigger both vascular pathology and inflammation and is activated in AD patients and AD mice. We have investigated the role of the contact system in AD pathogenesis. Cleavage of high-molecular-weight kininogen (HK), a marker for activation of the inflammatory arm of the contact system, is increased in a mouse model of AD, and this cleavage is temporally correlated with the onset of brain inflammation. Depletion of FXII in AD mice inhibited HK cleavage in plasma and reduced neuroinflammation, fibrinogen deposition, and neurodegeneration in the brain. Moreover, FXII-depleted AD mice showed better cognitive function than untreated AD mice. These results indicate that FXII-mediated contact system activation contributes to AD pathogenesis, and therefore this system may offer novel targets for AD treatment. © 2017 by The American Society of Hematology.

  10. Plasma levels of factor XII, prekallikrein and high molecular weight kininogen in normal blood donors and patients having suffered venous thrombosis.

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    Gallimore, Michael J; Harris, Simon L; Jones, David W; Winter, Mark

    2004-01-01

    The contact system proteins factor XII (FXII), prekallikrein (PK) and high molecular weight kininogen (HK) have roles in coagulation, fibrinolysis, thrombin-induced platelet activation, cell adhesion and angeogenisis. It has been suggested that inherited or acquired deficiencies of these proteins may be risk factors for thrombosis. Studies on the levels of FXII in plasma from normal and thrombotic patient populations have been reported, to our knowledge however, no systematic study on plasma levels of PK and HK in large populations of normal blood donors and patients having had venous thrombotic events has been performed. Chromogenic substrate assays were used to measure plasma levels of FXII, PK and HK in 300 normal blood donors (ND) and 300 patients attending our anticoagulant clinic who had a history of venous thrombosis (deep vein thrombosis or pulmonary embolism [VT]). All subjects were Caucasian, antiphospholipid antibody negative and had normal liver function. Mean values +/- SD were: FXII: ND 99.4 +/- 26.7%: VT 91.0 +/- 27.2%: PKK: ND 99.7 +/- 19.8%: VT 99.1 +/- 21.2%: HK: ND 101.0 +/- 20.5%: VT 110.7 +/- 32.3%. Statistical analysis of the data revealed significantly lower (pPKK: 66.8%, HK: 63.4%. The prevalence of values below the lower limit of normal were FXII-ND 2.3%: FXII-VT 8.0%, PKK-ND 3.0%: PKK-VT 4.7%, HK-ND 2.3%: HK-VT 5.0%. No homozygous deficiency patients were found for any parameter. One VT patient had combined FXII and HK deficiency and one ND and two VT patients had combined PK and HK deficiency. FXII levels were lower and HK levels and the prevalence of FXII, PK and HK deficiency higher in a population of patients with a history of VT than in a population of healthy blood donors.

  11. Factor XII assay

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    ... D, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, ... Laboratory evaluation of hemostatic and thrombotic disorders. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, ...

  12. Moderation of prekallkrein-factor XII interactions in surface activation of coagulation by protein-adsorption competition.

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    Chatterjee, Kaushik; Thornton, Jennifer L; Bauer, James W; Vogler, Erwin A; Siedlecki, Christopher A

    2009-10-01

    Traditional biochemistry of contact activation of blood coagulation suggesting that anionic hydrophilic surfaces are specific activators of the cascade is inconsistent with known trends in protein adsorption. To investigate contact activation reactions, a chromogenic assay was used to measure prekallkrein (PK) hydrolysis to kallikrein (Kal) by activated factor XII (FXIIa) at test hydrophilic (clean glass) and hydrophobic (silanized glass) surfaces in the presence of bovine serum albumin (BSA). Hydrolysis of PK by FXIIa is detected after contact of the zymogen FXII with a test hydrophobic surface only if putatively-adsorbed FXIIa is competitively displaced by BSA. By contrast, FXIIa activity is detected spontaneously following FXII activation by a hydrophilic surface and requires no adsorption displacement. These results (i) show that an anionic hydrophilic surface is not a necessary cofactor for FXIIa-mediated hydrolysis of PK, (ii) indicate that PK hydrolysis does not need to occur by an activation complex assembled directly on an anionic, activating surface, (iii) confirms that contact activation of FXII (autoactivation) is not specific to anionic hydrophilic surfaces, and (iv) demonstrates that protein-adsorption competition is an essential feature that must be included in any comprehensive mechanism of surface-induced blood coagulation.

  13. The binding of bovine factor XII to kaolin.

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    Kirby, E P; McDevitt, P J

    1983-04-01

    Purified bovine factor XII was radiolabeled with iodine-125 and its binding to kaolin studied. Binding was rapid and was not readily reversible upon adding unlabeled factor XII. The optimum pH for binding was in the region of pH 5-7. The isoelectric point of factor XII was pH 5.7. High concentrations of urea or increasing the ionic strength of the medium did not inhibit binding. Polyvalent macromolecules, such as Polybrene and polylysine, were effective inhibitors of factor XII binding to kaolin. Polylysine caused the release of factor XII that had bound to the kaolin surface.

  14. Factor XII binding to endothelial cells depends on caveolae

    DEFF Research Database (Denmark)

    Schousboe, Inger; Thomsen, Peter; van Deurs, Bo

    2004-01-01

    to human umbilical vein endothelial cells (HUVEC) has never been shown to be localized to these specialized membrane structures. Using microscopical techniques, we here report that FXII binds to specific patches of the HUVEC plasma membrane with a high density of caveolae. Further investigations of FXII...... lipid rafts. Accordingly, cholesterol-depleted cells were found to bind significantly reduced amounts of FXII. These observations, combined with the presence of a minority of u-PAR in caveolae concomitant with FXII binding, indicate that FXII binding to u-PAR may be secondary and depends upon...... the structural elements within caveolae. Thus, FXII binding to HUVEC depends on intact caveolae on the cellular surface....

  15. Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system.

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    Shannon L Taylor

    Full Text Available Hemorrhagic fever with renal syndrome (HFRS and hantavirus pulmonary syndrome (HPS are diseases caused by hantavirus infections and are characterized by vascular leakage due to alterations of the endothelial barrier. Hantavirus-infected endothelial cells (EC display no overt cytopathology; consequently, pathogenesis models have focused either on the influx of immune cells and release of cytokines or on increased degradation of the adherens junction protein, vascular endothelial (VE-cadherin, due to hantavirus-mediated hypersensitization of EC to vascular endothelial growth factor (VEGF. To examine endothelial leakage in a relevant in vitro system, we co-cultured endothelial and vascular smooth muscle cells (vSMC to generate capillary blood vessel-like structures. In contrast to results obtained in monolayers of cultured EC, we found that despite viral replication in both cell types as well as the presence of VEGF, infected in vitro vessels neither lost integrity nor displayed evidence of VE-cadherin degradation. Here, we present evidence for a novel mechanism of hantavirus-induced vascular leakage involving activation of the plasma kallikrein-kinin system (KKS. We show that incubation of factor XII (FXII, prekallikrein (PK, and high molecular weight kininogen (HK plasma proteins with hantavirus-infected EC results in increased cleavage of HK, higher enzymatic activities of FXIIa/kallikrein (KAL and increased liberation of bradykinin (BK. Measuring cell permeability in real-time using electric cell-substrate impedance sensing (ECIS, we identified dramatic increases in endothelial cell permeability after KKS activation and liberation of BK. Furthermore, the alterations in permeability could be prevented using inhibitors that directly block BK binding, the activity of FXIIa, or the activity of KAL. Lastly, FXII binding and autoactivation is increased on the surface of hantavirus-infected EC. These data are the first to demonstrate KKS activation

  16. Association of FXII 5’UTR 46C>T polymorphism with FXII activity and risk of thrombotic disease

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    Parisa Rasighaemi

    2010-03-01

    Full Text Available Objective: Thrombotic diseases are caused by genetic and environmental factors. There are a number of well-characterized genetic defects that lead to increased risk of thrombosis. Results from previous studies have indicated that FXII is involved in the pathogenesis of thrombophilic diseases. However, the results in this regard are highly controversial. One of the most important determinants of Plasma FXII level is 46CgT polymorphism in the FXII gene. In the present study, the risk of thrombophilic diseases related to this polymorphism was investigated in a case-control study. Material and Methods: One hundred and sixty subjects were studied: 120 patients diagnosed with thrombophilia (96 venous thromboembolism, 24 arterial thrombosis, and 40 age-gender-matched controls. For each subject, FXII activity level was measured by a one-step clotting assay with FXII-deficient plasma, and 46CγT polymorphism was genotyped using a restriction fragment length polymorphism (RFLP method. Results: In this study, the previous observation that individuals with different genotypes for the 46 CγT polymorphism show significant differences in FXII activity levels was confirmed. Most importantly, FXII activity ≤68% was associated with an increased risk of venous thrombosis with an adjusted odds ratio (OR of 4.7 (95% confidence interval [CI]: 1.03-21.1, p=0.04. However, it was not a risk factor for arterial thrombosis with adjusted OR of 5 (95% CI: 0.91-27.1, p=0.09. In CT and TT genotype, the adjusted ORs were 2 (95% CI: 0.9-4.4, p=0.11 and 2.3 (95% CI: 0.45-11, p=0.48, respectively, for patients with venous thrombosis compared with the controls. Similarly, the adjusted ORs in arterial thrombosis were 1.2 (95% CI: 0.4-3.6, p=0.76 for CT and 1.8 (95% CI: 0.2-14.9, p=0.59 for TT genotype. Thus, we did not find any association of the mutated T allele in the heterozygous or homozygous state with an increased risk of venous or arterial thrombosis. Conclusion: Lower

  17. Mechanism of surface-mediated activation of bovine Factor XII and prekallikrein.

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    Sugo, T; Ohno, Y; Shimada, T; Kato, H; Iwanaga, S

    1983-01-01

    The mechanism of kaolin-mediated activation of bovine Factor XII was studied in the presence of prekallikrein and HMW kininogen. The activated enzymes were assayed using fluorogenic peptides, Boc-Glu (OBzl)-Gly-Arg-4-methylcoumaryl-7-amide (MCA) for Factor XIIa and Z-Phe-Arg-MCA for plasma kallikrein. The rates of activation of the zymogens were separately measured by blocking either of the active enzymes with specific inhibitors, corn inhibitor for Factor XIIa (Ki = 6.7 nM) and Trasylol for plasma kallikrein (Ki = 3.9 nM). The result was as follows: (1) At the early stage of the activation reaction, kallikrein activity was first generated after short lag time, and then Factor XIIa activity was generated with a sigmoidal curve. In the presence of corn inhibitor, the activation of prekallikrein was observed, but in the presence of Trasylol, the activation of Factor XII was not observed. In the presence of high concentration of Ala-Phe-Arg-Ch2Cl, which inactivates immediately both of the active enzymes, the cleavage of a single chain prekallikrein into the two chain form by Factor XII was shown by SDS-PAGE, using nonlabelled and tritiated prekallikrein. (2) The incubation of Factor XII alone in a quartz cuvette or in the presence of kaolin and HMW kininogen did not result in the activation of Factor XII. The concave upward curve due to an autocatalytic activation was not observed even after the addition of Factor XIIa to Factor XII preparation. Moreover, no structural change of Factor XII during the incubation with kaolin and HMW kininogen was shown by SDS-PAGE, using 3H-Factor XII. (3) The rates of activation of prekallikrein by Factor XII and by Factor XIIa were approximately the same at higher concentration of prekallikrein. However, at lower concentration of prekallikrein the rate of activation of prekallikrein by Factor XII was shown to be a sigmoidal curve and slower than that by Factor XIIa. These results indicate that the activation of bovine Factor XII is

  18. Role of HMW kininogen in surface-mediated activation of Factor XII.

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    Shimada, T; Sugo, T; Kato, H; Iwanaga, S

    1983-01-01

    We have shown that bovine HMW kininogen remarkably accelerates the activation of Factor XII and prekallikrein in the presence of kaolin, adsorbing on kaolin through the fragment 1.2 region and forming a complex with prekallikrein through the light chain region (Sugo et al., 1980; Ikari et al., 1981). The present study was undertaken to examine the role of HMW kininogen in the activation of Factor XII and prekallikrein with other negatively-charged surfaces. The activation system used here was as follows; (1) Activation of prekallikrein by Factor XII, (2) Activation of Factor XII by plasma kallikrein and (3) Activation of prekallikrein by Factor XIIa. Among a variety of foreign surfaces, amylose sulfate and sulfatide were the most efficient in the activation reaction of Factor XII and prekallikrein. Bovene HMW kininogen accelerated all the three reactions triggered by these surfaces. However, the accelerating effect of HMW kininogen on the activation of Factor XII by plasma kallikrein was very weak, when amylose sulfate or sulfatide was used as surface. The three reactions were highly dependent on the amounts of HMW kininogen and surfaces contained in the reaction mixtures. Excess amount of them inhibited these reactions. Among the various fragments, which were prepared from HMW kininogen digests with plasma and urinary kallikreins (Sugo et al., 1980), a large fragment consisting of fragment 1.2 and light chain accelerated the reactions. Thus both fragment 1.2 and the light chain region in HMW kininogen were essential for these activation reactions.

  19. Prekallikrein, HMW-kininogen and factor XII in various disease states.

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    Deutsch, E; Dragosics, B; Kopsa, H; Mannhalter, C; Rainer, H

    1983-07-15

    The behaviour of prekallikrein (PKK), factor XII, high molecular weight kininogen (HMWK) and kallikrein-inhibitor (KK-I) in 367 patients with various diseases is described. Malignancies lead to elevation of factor XII and KK-I, and reduction of PKK. The effect is more pronounced in patients with metastases. In renal diseases also one or more of the above mentioned parameters are abnormal. Defects requiring dialysis treatment significantly impair the contact factors. In this group low levels of PKK, Factor XII and HMWK and increased KK-I are common. In chronic renal disease patients, only F XII and KK-I are elevated, whereas PKK and HMWK are normal. Kidney transplantation leads to a rise in KK-I and reduction of PKK and HMWK. The values almost normalize few days after the operation. Factor XII, slightly increased immediately after transplantation, remains high in long term transplant recipients, whereas HMWK falls below normal. In liver disease patients, acute and chronic hepatitis, cirrhosis of the liver and coma, PKK is reduced. In cases with acute hepatitis PKK raises with recovery. Cirrhosis and coma lead to low HMWK and factor XII concentrations. KK-I is mostly affected during acute hepatitis, and is then highly increased. Our results clearly demonstrate that the biologic activity of one or more of contact factors is affected in many diseases.

  20. Rosai-Dorfman disease with factor XII deficiency.

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    Kasapoglu Gunal, Esen; Kamali, Sevil; Akdogan, Mehmet Fatih; Cimen, Arif Oguz; Ocal, Lale; Agan, Mehmet; Gul, Ahmet; Inanc, Murat; Konice, Meral; Aral, Orhan

    2009-06-01

    A 17-year-old female patient presented with chronic symmetrical oligoarthritis of both knees and ankles, xerostomia, xerophthalmia, multiple bilateral lymphadenopathies in the cervical region, and bilateral parotid enlargement with the histological finding of chronic sialoadenitis. She had been already given methotrexate, chloroquine, and corticosteroids with the diagnosis of rheumatoid arthritis (RA) before referral to our outpatient clinic. Because her complaints and the lumps did not remit and she could be classified as neither RA nor primary Sjögren's syndrome (SS) according to 1987 ACR RA criteria or European preliminary criteria for SS, lymph node biopsy was repeated and revealed the diagnosis of Rosai-Dorfman disease (RDD) with the histological findings of histiocytes, phagocyting lymphocytes in enlarged sinuses, and mature plasma cells infiltrating the pulpa. All the medications were stopped after the pathological diagnosis of RDD and consulting with the Division of Hematology. She was reevaluated with magnetic resonance imaging, which showed dense infiltrative areas around knee and ankle joints, and computed tomography that showed a soft tissue mass surrounding the descending aorta and upper part of the abdominal aorta. Activated partial thromboplastin time was found to be prolonged in prebiopsy examinations, and factor XII deficiency was detected after detailed hematological evaluation. The symptoms of joint involvement were relieved with nonsteroidal antiinflammatory drugs. She has been followed-up without medication without obvious clinical or laboratory change. We herein report a patient with RDD mimicking RA and SS. We consider that RDD should be kept in mind especially in patients with resistant symptoms to conventional therapies, younger disease onset, and predominant parotid and lymph node enlargement.

  1. Factor XII-independent activation of the bradykinin-forming cascade

    DEFF Research Database (Denmark)

    Joseph, Kusumam; Tholanikunnel, Baby G; Bygum, Anette

    2013-01-01

    and assayed for kallikrein formation. C1-INH was removed from factor XII-deficient plasma by means of immunoadsorption. RESULTS: We demonstrate that prekallikrein-HK will activate to kallikrein in phosphate-containing buffers and that the rate is further accelerated on addition of heat shock protein 90....... Prolonged incubation of plasma deficient in both factor XII and C1-INH led to conversion of prekallikrein to kallikrein and cleavage of HK, as was seen in plasma from patients with hereditary angioedema but not plasma from healthy subjects. CONCLUSIONS: These results indicate that C1-INH stabilizes...

  2. Factor XII mutations, estrogen-dependent inherited angioedema, and related conditions

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    Binkley Karen E

    2010-07-01

    Full Text Available Abstract The clinical, biochemical and genetic features of the conditions known as estrogen-dependent inherited angioedema, estrogen-associated angioedema, hereditary angioedema with normal C-1 inhibitor, type III angioedema, or factor XII angioedema are reviewed. Discussion emphasizes pathogenesis, diagnosis, and management.

  3. Factor XII mutations, estrogen-dependent inherited angioedema, and related conditions

    OpenAIRE

    Binkley Karen E

    2010-01-01

    Abstract The clinical, biochemical and genetic features of the conditions known as estrogen-dependent inherited angioedema, estrogen-associated angioedema, hereditary angioedema with normal C-1 inhibitor, type III angioedema, or factor XII angioedema are reviewed. Discussion emphasizes pathogenesis, diagnosis, and management.

  4. FACTOR-XII FRAGMENT AND KALLIKREIN GENERATION IN PLASMA DURING INCUBATION WITH BIOMATERIALS

    NARCIS (Netherlands)

    VANDERKAMP, KWHJ; VANOEVEREN, W

    Blood biocompatibility of medical devices is in many ways dependent on surface characteristics and biochemical blood material interactions. In this study, the contact system, in which the activation of factor XII and plasma kallikrein is included, is highlighted. This article describes a simple

  5. Acquired factor XII deficiency in a woman with recurrent pregnancy loss: working on a differential diagnosis in a single case

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    Di Micco Pierpaolo

    2005-12-01

    Full Text Available Abstract Background Antiphospholipid syndrome (APS has been often associated to RPL since 1980 and some reports in the Literature rarely described antibodies to factor XII in patients with APS. Case history We report the case history of 34-year-old caucasian women with recurrent fetal loss and persistent prolonged activated partial thromboplastin time. Haemostatic tests revealed persistent light decrease of clotting factor XII with normal values of IgG and IgM anticardiolipin antibodies and transient positivity for lupus anticoagulant (LA. Few reports in the Literature described antibodies to factor XII in patient with antiphospholipid syndrome (APS and transient LA. So, once other causes of RPL were excluded, the patient was diagnosed an unusual form of APS associated to antibodies to factor XII, reduced factor XII plasma levels, transient LA and prolonged activated partial thromboplastin time. Discussion We suggest to consider also antibodies directed to clotting factors (e.g. factor XII in our case as second step of thrombophilia screening in RPL, in particular if a persistent prolonged aPTT is present without an apparent cause.

  6. Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitors

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    Gozzo A.J.

    2003-01-01

    Full Text Available Human plasma kallikrein, a serine proteinase, plays a key role in intrinsic blood clotting, in the kallikrein-kinin system, and in fibrinolysis. The proteolytic enzymes involved in these processes are usually controlled by specific inhibitors and may be influenced by several factors including glycosaminoglycans, as recently demonstrated by our group. The aim of the present study was to investigate the effect of glycosaminoglycans (30 to 250 µg/ml on kallikrein activity on plasminogen and factor XII and on the inhibition of kallikrein by the plasma proteins C1-inhibitor and antithrombin. Almost all available glycosaminoglycans (heparin, heparan sulfate, bovine and tuna dermatan sulfate, chondroitin 4- and 6-sulfates reduced (1.2 to 3.0 times the catalytic efficiency of kallikrein (in a nanomolar range on the hydrolysis of plasminogen (0.3 to 1.8 µM and increased (1.9 to 7.7 times the enzyme efficiency in factor XII (0.1 to 10 µM activation. On the other hand, heparin, heparan sulfate, and bovine and tuna dermatan sulfate improved (1.2 to 3.4 times kallikrein inhibition by antithrombin (1.4 µM, while chondroitin 4- and 6-sulfates reduced it (1.3 times. Heparin and heparan sulfate increased (1.4 times the enzyme inhibition by the C1-inhibitor (150 nM.

  7. Trombosis cerebral en presencia de un inhibidor especifico contra el factor xii de la coagulación

    OpenAIRE

    Martínez Betancur, Octavio; López de Goenaga, Inés

    2011-01-01

    El presente informe determina la especificidad de un inhibidor de la coagulación dirigido contra el factor XII, activador intrínseco de la fibrinólisis plasmática, en un paciente con un evento oclusivo vascular cerebral agudo de tipo trombótico, sobre un transfondo de múltiples infartos cerebrales antiguos. Se excluyó la presencia de anticoagulante lúpico mediante la prueba de neutralización de plaquetas. Como resultado de la inhibición del factor XII, se demostró la ausencia de actividad fib...

  8. The polyphosphate/factor XII pathway in cancer-associated thrombosis: novel perspectives for safe anticoagulation in patients with malignancies.

    Science.gov (United States)

    Nickel, Katrin F; Labberton, Linda; Long, Andrew T; Langer, Florian; Fuchs, Tobias A; Stavrou, Evi X; Butler, Lynn M; Renné, Thomas

    2016-05-01

    Cancer is an established risk factor for venous thromboembolism (VTE) and VTE is the second leading cause of death in patients with cancer. The incidence of cancer-related thrombosis is rising and is associated with worse outcomes. Despite our growing understanding on tumor-driven procoagulant mechanisms including cancer-released procoagulant proteases, expression of tissue factor on cancer cells and derived microvesicles, as well as alterations in the extracellular matrix of the cancer cell milieu, anticoagulation therapy in cancer patients has remained challenging. This review comments on a newly discovered cancer-associated procoagulant pathway. Experimental VTE models in mice and studies on patient cancer material revealed that prostate cancer cells and associated exosomes display the inorganic polymer polyphosphate on their plasma membrane. Polyphosphate activates blood coagulation factor XII and initiates thrombus formation via the intrinsic pathway of coagulation. Pharmacologic inhibition of factor XII activity protects mice from VTE and reduces thrombin coagulant activity in plasma of prostate cancer patients. Factor XII inhibitors provide thrombo-protection without impairing hemostatic mechanisms and thus, unlike currently used anticoagulants, do not increase bleeding risk. Interference with the polyphosphate/factor XII pathway may provide the novel opportunity for safe anticoagulation therapy in patients with malignancies.

  9. Kinetic studies on surface-mediated activation of bovine factor XII and prekallikrein. Effects of kaolin and high-Mr kininogen on the activation reactions.

    Science.gov (United States)

    Sugo, T; Kato, H; Iwanaga, S; Takada, K; Sakakibara, S

    1985-01-02

    The kaolin-mediated reciprocal activation of bovine factor XII and prekallikrein was divided into the following two reactions: the activation of factor XII by plasma kallikrein (reaction 1) and the activation of prekallikrein by factor XIIa (reaction 2). The effects of high-Mr kininogen and kaolin surface on the kinetics of these activation reactions were studied. High-Mr kininogen markedly enhanced the rate of reactions 1 and 2 in the presence of kaolin, and the enhancements were highly dependent on the concentrations of the protein cofactor and amount of kaolin surface. For the activation of factor XII by plasma kallikrein (reaction 1), high-Mr kininogen was required when a low concentration of factor XII and kaolin was used. The molar ratio of the protein cofactor to factor XII for optimal activation was found to be approximately 1:1. The apparent Km value and the kcat/Km value for plasma kallikrein on factor XII were calculated to be 4 nM and 5.2 X 10(7) s-1 X M-1, respectively. The activation of prekallikrein by factor XIIa, (reaction 2) proceeded even in the absence of high-Mr kininogen and kaolin. The addition of the protein cofactor and surface to the reaction mixture remarkably accelerated the reaction, and the apparent Km value for factor XIIa on prekallikrein was reduced from 1 microM to 40 nM. Moreover, the kcat/Km value was altered from 7.3 X 10(4) to 1.1 X 10(6) s-1 X M-1). These results suggest that high-Mr kininogen accelerates the surface-mediated activation of factor XII and prekallikrein by enhancing the susceptibility of factor XII to plasma kallikrein, on the one hand, and the affinity of factor XIIa for prekallikrein, on the other hand. Kaolin may play an important role in the concentration and organization of these components on the negatively charged surface.

  10. Isolation of bovine platelet cationic proteins which inhibit the surface-mediated activation of factor XII and prekallikrein.

    Science.gov (United States)

    Kodama, K; Kato, H; Iwanaga, S

    1985-01-01

    A possible role of bovine platelets in the surface-mediated activation of Factor XII and prekallikrein was studied, using the contact system reconstituted with the purified proteins from bovine plasma. The washed platelets before and after aggregation by ADP, thrombin or collagen did not show any ability to trigger or accelerate the activation of Factor XII and prekallikrein. On the contrary, these aggregates showed a potent inhibitory activity on the activation of those zymogens triggered by kaolin, amylose sulfate and sulfatide. The inhibitory substances from the supernatant of the thrombin-induced aggregates were separated into two major fractions, a low affinity fraction and a high affinity fraction, on a heparin-Sepharose column. The high affinity protein was identified as platelet factor 4, based on the amino acid composition. From the low affinity fraction, a beta-thromboglobulin (beta-TG)-like substance and three kinds of unknown proteins, named LA1, LA2, and LA3, were isolated by gel-filtration on a column of Sephadex G-100 or Sephadex G-75 followed by chromatography on a column of Mono S. The molecular weights of LA1, LA2, and LA3 were estimated to be 35,000, 26,000, and 11,000, respectively, on SDS-PAGE. LA2 was identified as a carbohydrate-less LA1, as judged from the amino acid composition and carbohydrate content. The inhibitory activities of these five cationic proteins on the activation of Factor XII and prekallikrein mediated with amylose sulfate, sulfatide and kaolin were different from each other. In the case of kaolin-mediated activation, LA3 was the most potent inhibitor, while platelet factor 4 and beta-TG-like substance did not show any significant inhibitory activity. Moreover, the inhibitory activities of all the cationic proteins were not correlated with their anti-heparin activities. Since these proteins were rapidly liberated from platelets by the action of the stimulants, the present results demonstrate a negative role of platelets in

  11. C1-inhibitor polymers activate the FXII-dependent kallikrein-kinin system

    DEFF Research Database (Denmark)

    Elenius Madsen, Daniel; Sidelmann, Johannes Jakobsen; Biltoft, Daniel

    2015-01-01

    attacks. HAE is caused by mutations in the C1-inh encoding gene, and we recently demonstrated that some mutations give rise to the presence of polymerized C1-inh in the plasma of HAE patients. METHODS: C1-inh polymers corresponding to the size of polymers observed in vivo were produced using heat...... denaturation and gel filtration. The ability of these polymers to facilitate FXII activation was assessed in vitro in an FXII activation bandshift assay. After spiking of plasma with C1-inh polymers, kallikrein generation was analyzed in a global kallikrein generation method. Prekallikrein consumption...... in the entire Danish HAE cohort was analyzed using an ELISA method. RESULTS: C1-inh polymers mediated FXII activation, and a dose dependent kallikrein generation in plasma spiked with C1-inh polymers. An increased (pre)kallikrein consumption was observed in plasma samples from HAE patients presenting with C1...

  12. A major gene mapped on chromosome XII is the main factor of a quantitatively inherited resistance to Meloidogyne fallax in Solanum sparsipilum.

    Science.gov (United States)

    Kouassi, Abou Bakari; Bakari, Kouassi Abou; Kerlan, Marie-Claire; Marie-Claire, Kerlan; Caromel, Bernard; Bernard, Caromel; Dantec, Jean-Paul; Jean-Paul, Dantec; Fouville, Didier; Didier, Fouville; Manzanares-Dauleux, Maria; Maria, Manzanares-Dauleux; Ellissèche, Daniel; Daniel, Ellissèche; Mugniéry, Didier; Didier, Mugniéry

    2006-02-01

    Meloidogyne fallax is an emerging pest in Europe and represents a threat for potato production. We report the mapping of genetic factors controlling a quantitative resistance against M. fallax identified in the Solanum sparsipilum genotype 88S.329.15. When infected, this genotype develops a necrotic reaction at the feeding site of the juveniles and totally prevents their development to the female stage. A "F1" diploid progeny consisting of 128 individuals was obtained using the potato (S. tuberosum) dihaploid genotype BF15 H1 as female progenitor. Sixty-eight hybrid genotypes displayed necrosis at the feeding site of the juveniles and 60 other genotypes showed no defence reaction. This suggested a monogenic control of the resistance. However, when considering the number of nematode females developed in their roots, a continuous distribution was observed for both "necrotic" and "non-necrotic" hybrid genotypes, indicating a polygenic control of the resistance. A linkage map of each parental genotype was constructed using AFLP markers. The necrotic reaction (NR) was mapped as a qualitative trait on chromosome XII of the resistant genotype 88S.329.15. Quantitative trait locus (QTL) analysis for the number of nematode females developed per "F1" plant genotype was performed using the QTL cartographer software. No QTL was detected on the linkage map of the susceptible parent. A QTL explaining 94.5% of the phenotypic variation was mapped on chromosome XII of the resistant progenitor. This QTL, named MfaXIIspl, was mapped in a genomic region collinear to the map position of the Mi-3 gene conferring resistance to Meloidogyne incognita in tomato. It corresponds to the NR locus.

  13. Pío XII

    Directory of Open Access Journals (Sweden)

    Álvaro Sánchez

    1958-10-01

    Full Text Available Acatando los supremos valores que todos los Pontífices representan, es fuerza reverenciar personalidades superiores que desde la cátedra de San Pedro han brillado como luminares excelsos. Aun no extinguida la preciosa existencia de Pío XII, ya la pluma de acuciosos historiógrafos se había ocupado de reunir y contar a los cristianos lectores las múltiples actividades del eximio Pontífice.

  14. Interactions outside the proteinase-binding loop contribute significantly to the inhibition of activated coagulation factor XII by its canonical inhibitor from corn.

    Science.gov (United States)

    Korneeva, Vera A; Trubetskov, Mikhail M; Korshunova, Alena V; Lushchekina, Sofya V; Kolyadko, Vladimir N; Sergienko, Olga V; Lunin, Vladimir G; Panteleev, Mikhail A; Ataullakhanov, Fazoil I

    2014-05-16

    Activated factor XII (FXIIa) is selectively inhibited by corn Hageman factor inhibitor (CHFI) among other plasma proteases. CHFI is considered a canonical serine protease inhibitor that interacts with FXIIa through its protease-binding loop. Here we examined whether the protease-binding loop alone is sufficient for the selective inhibition of serine proteases or whether other regions of a canonical inhibitor are involved. Six CHFI mutants lacking different N- and C-terminal portions were generated. CHFI-234, which lacks the first and fifth disulfide bonds and 11 and 19 amino acid residues at the N and C termini, respectively, exhibited no significant changes in FXIIa inhibition (Ki = 3.2 ± 0.4 nm). CHFI-123, which lacks 34 amino acid residues at the C terminus and the fourth and fifth disulfide bridges, inhibited FXIIa with a Ki of 116 ± 16 nm. To exclude interactions outside the FXIIa active site, a synthetic cyclic peptide was tested. The peptide contained residues 20-45 (Protein Data Bank code 1BEA), and a C29D substitution was included to avoid unwanted disulfide bond formation between unpaired cysteines. Surprisingly, the isolated protease-binding loop failed to inhibit FXIIa but retained partial inhibition of trypsin (Ki = 11.7 ± 1.2 μm) and activated factor XI (Ki = 94 ± 11 μm). Full-length CHFI inhibited trypsin with a Ki of 1.3 ± 0.2 nm and activated factor XI with a Ki of 5.4 ± 0.2 μm. Our results suggest that the protease-binding loop is not sufficient for the interaction between FXIIa and CHFI; other regions of the inhibitor also contribute to specific inhibition.

  15. Crew Factors in Flight Operations XII: A Survey of Sleep Quantity and Quality in On-Board Crew Rest Facilities

    Science.gov (United States)

    Rosekind, Mark R.; Gregory, Kevin B.; Co, Elizabeth L.; Miller, Donna L.; Dinges, David F.

    2000-01-01

    Many aircraft operated on long-haul commercial airline flights are equipped with on-board crew rest facilities, or bunks, to allow crewmembers to rest during the flight. The primary objectives of this study were to gather data on how the bunks were used, the quantity and quality of sleep obtained by flight crewmembers in the facilities, and the factors that affected their sleep. A retrospective survey comprising 54 questions of varied format addressed demographics, home sleep habits, and bunk sleep habits. Crewmembers from three airlines with long-haul fleets carrying augmented crews consisting of B747-100/200, B747-400, and MD-11 aircraft equipped with bunks returned a total of 1404 completed surveys (a 37% response rate). Crewmembers from the three carriers were comparable demographically, although one carrier had older, more experienced flight crewmembers. Each group, on average, rated themselves as "good" or "very good" sleepers at home, and all groups obtained about the same average amount of sleep each night. Most were able to sleep in the bunks, and about two thirds indicated that these rest opportunities benefited their subsequent flight deck alertness and performance. Comfort, environment, and physiology (e.g., being ready for sleep) were identified as factors that most promoted sleep. Factors cited as interfering with sleep included random noise, thoughts, heat, and the need to use the bathroom. These factors, in turn, suggest potential improvements to bunk facilities and their use. Ratings of the three aircraft types suggested differences among facilities. Bunks in the MD-11 were rated significantly better than either of the B747 types, and the B747-400 bunks received better ratings than did the older, B747-100/200 facilities.

  16. XII Elkonin Readings

    Directory of Open Access Journals (Sweden)

    Bugrimenko E.A.,

    2016-07-01

    Full Text Available The article introduces the reader the main content of report presented at the XII Elkonin Readings (4th March, 2016. Elkonin Readings takes place each 2 years in Psychological Institute, Russian Academy of education. This year they are focused on the problem of “Mediation and development”. Speakers from different institutions presented their approaches to solving these problems. The theoretical foundation of the new understanding of the relationship of functional genesis and ontogenesis, buildings mediation activities, proximal development areas have been disclosed in the articles of V.V. Rubtsov, D.B. Elkonin, P.G. Nezhnov. The new conditions for mediation were created on the basis of the different materials (games, reading, and spatial image of “self” according to an experimental practice of teaching and correction of self- development. Developing of creative ways of mediation were mentioned in the articles of L.I. Elkoninov, E.O. Smirnov, E.A. Abdulaeva, E.A. Bugrimenko, N.U. Mangutov, that meet actual problems for modern children.

  17. The role of bovine high-molecular-weight (HMW) kininogen in contact-mediated activation of bovine factor XII: interaction of HMW kininogen with kaolin and plasma prekallikrein.

    Science.gov (United States)

    Ikari, N; Sugo, T; Fujii, S; Kato, H; Iwanaga, S

    1981-06-01

    Previous studies from our laboratories (Sugo et al. (1980) Biochemistry 19, 3215-3220) have shown that bovine high-molecular-weight (HMW) kininogen remarkably accelerates the kaolin-mediated activation of Factor XII in the presence of prekallikrein, and that both fragment 1.2 and the light chain regions located in the COOH terminal half of the kininogen molecule are essential for the activation. In the present study, we demonstrate that the accelerating effect of HMW kininogen is mediated through its adsorption on the kaolin surface through the fragment 1.2 region and its complex formation with prekallikrein through the light chain region. The evidence is as follows: 1. HMW kininogen radio-labeled with 125I was adsorbed on kaolin and the adsorption was inhibited by the prior treatment of kaolin with fragment 1.2, fragment 1.2-light chain, kinin-free protein or HMW kininogen, but not with kinin- and fragment 1.2-free protein, light chain or low molecular-weight (LMW) kininogen. 2. The complex formation of HMW kininogen with prekallikrein in bovine plasma or in the purified system was examined by gel-filtration on a column of Sephacryl S-200 In bovine plasma, prekallikrein was eluted in the same fraction as HMW kininogen, showing an apparent molecular weight of 250,000, whereas purified prekallikrein was eluted in the fraction corresponding to an apparent molecular weight of 100,000. When purified prekallikrein was mixed with purified HMW kininogen in a mol ratio of 1 to 2, all prekallikrein was found to be associated with HMW kininogen. Furthermore, purified prekallikrein mixed with kininogen derivatives, such as kinin- and fragment 1.2-free protein, fragment 1.2-light chain or light chain, was eluted in the higher molecular weight fraction. HMW kininogen did not form a complex with prekallikrein. Using the same technique, it was shown that kinin- and fragment 1.2-free protein forms a complex not only with prekallikrein but also with kallikrein.

  18. The Effect of Carbon Dioxide Insufflation Applied at Different Pressures and Periods on Thrombotic Factors.

    Science.gov (United States)

    Sen, Mehmet Celal; Turkyilmaz, Zafer; Sonmez, Kaan; Karabulut, Ramazan; Kaya, Zuhre; Yenicesu, Idil; Gursel, Turkiz; Basaklar, Abdullah Can

    2016-03-01

    The aim of this experimantal study which is applied on rats, is to determine the differences on the clotting factors over the application of low and high intraabdominal pressure (IAP) values in different periods of time in carbon dioxide (CO2) pneumoperitoneum. Thirty rats were randomized into five groups (n = 6): a control group (Group K) and 1 h and 6 mm Hg IAP (Group A), 2 h and 6 mm Hg IAP (Group B), 1 h and 12 mm Hg IAP (Group C) and 2 h and 12 mm Hg IAP were created with CO2 pneumoperitoneum (Group D). At the end of the experiment, plasma samples taken from subjects and fibrinogen, FII (prothrombin), FV, FVII, FVIII, FIX, FX, FXI, FXII, von willebrand's factor (vWF), ristocetin cofactor, protein C, protein S, antithrombin III (AT III) levels are studied. There were statistically significant differences in the mean levels of FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, and protein S between the groups. A hypercoagulable state occurred with the following: increase in the coagulation parameters compared to the control group; increase in FVII in the group only Group C; decrease in AT III in all groups compared to the control group; decrease in protein C in the group only XII Group D compared to control group; decrease in protein S in all groups except group D compared to control group. CO2 insufflation predisposes to thromboembolic events both by inducing coagulation factors and by suppressing the fibrinolytic system contrary to the controversies in the literature.

  19. Calibrated kallikrein generation in human plasma

    DEFF Research Database (Denmark)

    Biltoft, D; Sidelmann, J J; Olsen, L F

    2016-01-01

    OBJECTIVES: The physiological role of the contact system remains inconclusive. No obvious clinical complications have been observed for factor XII (FXII), prekallikrein (PK), or high molecular weight kininogen deficiencies even though the contact system in vitro is associated with coagulation...

  20. Chondrule Tieschitz XII Revisited: Reading a Very Old Logbook

    Science.gov (United States)

    Kurat, G.; Varela, M. E.; Zinner, E.

    2010-03-01

    Chondrule Tieschitz XII (Tie XII) was recently re-investigated with an ion micro-probe. Tie XII perfectly fit the PLC model (Varela and Kurat, 2009) and the theoretical predictions of phase condensation in a non-canonical solar nebula [Ebel 2006].

  1. Processing of Factor XII during Inflammatory Reactions

    NARCIS (Netherlands)

    Jukema, Bernard Nico; de Maat, Steven; Maas, Coen

    2016-01-01

    The contact system was originally identified as an obsolete part of the coagulation system, but it has been repeatedly implicated in inflammatory states, such as infection, as well as in allergic- and chronic inflammatory disease. Under these conditions, there is surprisingly little evidence that

  2. [XII National Forum on Health Education].

    Science.gov (United States)

    Ramiro-H, Manuel

    2015-01-01

    In Guadalajara, on August 19, 20 and 21 was held the XII Foro Nacional de Educación en Salud, in line with the interest that both, the Dirección General and the Dirección de Prestaciones Médicas of the IMSS, have in training and updating the human resources for the care of the beneficiaries. The Unidad de Educación, Investigación y Políticas de Salud organized a meeting in which the actors of these tasks, the institutional staff and authorities from various universities worked together with the IMSS.

  3. Plasmin-induced procoagulant effects in the blood coagulation: a crucial role of coagulation factors V and VIII.

    Science.gov (United States)

    Ogiwara, Kenichi; Nogami, Keiji; Nishiya, Katsumi; Shima, Midori

    2010-09-01

    Plasminogen activators provide effective treatment for patients with acute myocardial infarction. However, paradoxical elevation of thrombin activity associated with failure of clot lysis and recurrent thrombosis has been reported. Generation of thrombin in these circumstances appears to be owing to plasmin (Plm)-induced activation of factor (F) XII. Plm catalyzes proteolysis of several coagulant factors, but the roles of these factors on Plm-mediated procoagulant activity remain to be determined. Recently developed global coagulation assays were used in this investigation. Rotational thromboelastometry using whole blood, clot waveform analysis and thrombin generation tests using plasma, showed that Plm (> or =125 nmol/l) shortened the clotting times in similar dose-dependent manners. In particular, the thrombin generation test, which was unaffected by products of fibrinolysis, revealed the enhanced coagulation with an approximately two-fold increase of peak level of thrombin generation. Studies using alpha2-antiplasmin-deficient plasma revealed that much lower dose of Plm (> or =16 nmol/l) actually contributed to enhancing thrombin generation. The shortening of clotting time could be observed even in the presence of corn trypsin inhibitor, supporting that Plm exerted the procoagulant activity independently of FXII. In addition, using specific coagulation-deficient plasmas, the clot waveform analysis showed that Plm did not shorten the clotting time in only FV-deficient or FVIII-deficient plasma in prothrombin time-based or activated partial thromboplastin time-based assay, respectively. Our results indicated that Plm did possess procoagulant activity in the blood coagulation, and this effect was likely attributed by multicoagulation factors, dependent on FV and/or FVIII.

  4. 1. XII kell 13 avatakse Pärnu uue kunsti muuseumis...

    Index Scriptorium Estoniae

    2002-01-01

    Jõulunäitus "Kunst kuulub lastele!" kunstnike ja laste töödest. 6.-8. XII tekstiilipäevad (Anu Raud, Hilja Kulles); 13.-15. XII piparkoogipäevad; 20.-21. XII inglipäevad (kutsutud Ilon Wikland); 27-29. XII unenäopäevad (Enn Tegova). Saab vaadata Lasse Naukarise filmi "Kunstniku elu"

  5. Alates 13. XII on Vaala galeriis avatud "Talvesalong"

    Index Scriptorium Estoniae

    2004-01-01

    Väljas on Ellinor Aiki, Valdur Ohaka, Herman Talviku, Jaak Arro, Raoul Kurvitza, Andres Toltsi, Laurentsiuse, Lembit Saartsi, Rait Rosina, Merike Estna, Maarit Murka ning Aleksandr Breneri ja Barbara Schurzi tööd. 17. XII Anna Litvinova, Ilmar Kruusamäe ja Lembit Sarapuu ühised maaliseansid

  6. Karl XII rootsi kirjanduses / Anu Saluäär

    Index Scriptorium Estoniae

    Saluäär, Anu, 1948-

    2008-01-01

    Valikuline ülevaade Karl XII-st rootsi kirjanduses: Israel Holmström, Esaias Tegner, Zacharias Topelius, Carl Snoilsky, Anders Fryxell, Verner von Heidenstam, Harald Hiärne, Frans G. Bengtsson. Sisaldab märkusi joonealustes viidetes

  7. Alfonso XII: el rey que quiso ser constitucional

    OpenAIRE

    Lario González, María Ángeles

    2003-01-01

    La restauración de los Borbones en la persona del hijo de Isabel II, Alfonso XII, significó el inicio de una nueva etapa en la historia del liberalismo español. De nuevo, tras la sucesión de Constituciones de partido que significó la ruptura de los a

  8. Tallinna XII graafikatriennaali kuraatornäituse konkurss

    Index Scriptorium Estoniae

    2000-01-01

    Tallinna XII graafikatriennaal "Muutuv kujund" ("Mutating Image"), mis toimub 2001. a. sügisel, koosneb rahvusvahelise žüriiga Rotermanni soolalao põhinäitusest ja kuraatorinäitusest Tallinna Kunstihoones ja Linnagaleriis. Kirjalikke kontseptsioone oodatakse 1. märtsiks 2000.

  9. Alates 13. XII on Vaala galeriis avatud "Talvesalong"

    Index Scriptorium Estoniae

    2004-01-01

    Väljas on Ellinor Aiki, Valdur Ohaka, Herman Talviku, Jaak Arro, Raoul Kurvitza, Andres Toltsi, Laurentsiuse, Lembit Saartsi, Rait Rosina, Merike Estna, Maarit Murka ning Aleksandr Breneri ja Barbara Schurzi tööd. 17. XII Anna Litvinova, Ilmar Kruusamäe ja Lembit Sarapuu ühised maaliseansid

  10. On a six-parameter generalized Burr XII distribution

    OpenAIRE

    A. K. Olapade

    2008-01-01

    In this paper, we derive a probability density function that generalizes the Burr XII distribution. The cumulative distribution function and the $n^{th}$ moment of the generalized distribution are obtained while the distribution of some order statistics of the distribution are established. A theorem that relate the new distribution to another statistical distribution is established.

  11. Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones.

    Science.gov (United States)

    Sarikaya, Busra; Ceruso, Mariangela; Carta, Fabrizio; Supuran, Claudiu T

    2014-11-01

    A series of new Schiff bases was obtained from sulfanilamide, 3-fluorosulfanilamide or 4-(2-aminoethyl)-benzenesulfonamide and aromatic/heterocyclic aldehydes incorporating both hydrophobic and hydrophilic moieties. The obtained sulfonamides were investigated as inhibitors of four physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic CA I and II, as well as the transmembrane, tumor-associated CA IX and XII. Most derivatives were medium potency or weak hCA I/II inhibitors, but several of them showed nanomolar affinity for CA IX and/or XII, making them an interesting example of isoform-selective compounds. The nature of the aryl/hetaryl moiety present in the initial aldehyde was the main factor influencing potency and isoform selectivity. The best and most CA IX-selective compounds incorporated moieties such as 4-methylthiophenyl, 4-cyanophenyl-, 4-(2-pyridyl)-phenyl and the 4-aminoethylbenzenesulfonamide scaffold. The best hCA XII inhibitors, also showing selectivity for this isoform, incorporated 2-methoxy-4-nitrophenyl-, 2,3,5,6-tetrafluorophenyl and 4-(2-pyridyl)-phenyl functionalities and were also derivatives of 4-aminoethylbenzenesulfonamide. The sulfanilamide and 3-fluorosulfanilamide derived Schiff bases were less active compared to the corresponding 4-aminoethyl-benzenesulfonamide derivatives. As hCA IX/XII selective inhibition is attractive for obtaining antitumor agents/diagnostic tools with a new mechanism of action, compounds of the type described here may be considered interesting preclinical candidates.

  12. Natural pathways for factor XII activation : Implications for hereditary angioedema

    NARCIS (Netherlands)

    Maat, S. de

    2016-01-01

    It is well known that the swelling of tissue (edema) that occurs during an inflammation is the result of local vascular leakage. While histamine is the most well-known mediator of vascular leakage, other mediators such as bradykinin have also shown to be of importance. The contact system is an enzym

  13. Natural pathways for factor XII activation : Implications for hereditary angioedema

    NARCIS (Netherlands)

    Maat, S. de

    2016-01-01

    It is well known that the swelling of tissue (edema) that occurs during an inflammation is the result of local vascular leakage. While histamine is the most well-known mediator of vascular leakage, other mediators such as bradykinin have also shown to be of importance. The contact system is an

  14. 2. XII avati Tallinna Linnagaleriis Eve Kiileri näitus "Progressi arhitektoonika"

    Index Scriptorium Estoniae

    2003-01-01

    E. Kiiler on pildistatud Londoni, Pariisi, Stockholmi, Helsingi ja Tallinna ehitusplatse, tellinguid, soojakuid jt. ajutisi ehitisi. Väljapaneku I vaatus (3.-15. XII) näitab üldisemat vaadet, II vaatuses (17.-21. XII) on esil üldvaatest suurendatud fragmendid

  15. Jalutuskäik Tallinna galeriides laupäeval, 17. XII / Juta Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Juta, 1952-

    2005-01-01

    Jaan Elkeni ja Anu Põdra ühisnäitus "Mina ja tema" Deco galeriis kuni 30. XII. Kristin Kalamehe näitus "Mehed" Tallinna Linnagaleriis kuni 1. I 2006. Alice Kase joonistused Hobusepea galeriis 13.-19. XII. Rita Raave näitus "Vana sein" G-galeriis kuni 31. XII

  16. 40 CFR Appendix Xii to Part 266 - Nickel or Chromium-Bearing Materials that may be Processed in Exempt Nickel-Chromium Recovery...

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Nickel or Chromium-Bearing Materials that may be Processed in Exempt Nickel-Chromium Recovery Furnaces XII Appendix XII to Part 266... FACILITIES Pt. 266, App. XII Appendix XII to Part 266—Nickel or Chromium-Bearing Materials that may...

  17. XII International Conference of the Italian Association on Artificial Intelligence

    CERN Document Server

    Semeraro, Giovanni; Vargiu, Eloisa; New Challenges in Distributed Information Filtering and Retrieval : DART 2011: Revised and Invited Papers

    2013-01-01

    This volume focuses on new challenges in distributed Information Filtering and Retrieval. It collects invited chapters and extended research contributions from the DART 2011 Workshop, held in Palermo (Italy), on September 2011, and co-located with the XII International Conference of the Italian Association on Artificial Intelligence. The main focus of DART was to discuss and compare suitable novel solutions based on intelligent techniques and applied to real-world applications. The chapters of this book present a comprehensive review of related works and state of the art. Authors, both practitioners and researchers, shared their results in several topics such as "Multi-Agent Systems", "Natural Language Processing", "Automatic Advertisement", "Customer Interaction Analytics", "Opinion Mining".

  18. XII International Conference on the Theory of Machines and Mechanisms

    CERN Document Server

    Bílek, Martin; Žabka, Petr

    2017-01-01

    This book presents the most recent advances in the research of machines and mechanisms. It collects 54 reviewed papers presented at the XII International Conference on the Theory of Machines and mechanisms (TMM 2016) held in Liberec, Czech Republic, September 6-8, 2016. This volume offers an international selection of the most important new results and developments, grouped in six different parts, representing a well-balanced overview, and spanning the general theory of machines and mechanisms, through analysis and synthesis of planar and spatial mechanisms, linkages and cams, robots and manipulators, dynamics of machines and mechanisms, rotor dynamics, computational mechanics, vibration and noise in machines, optimization of mechanisms and machines, mechanisms of textile machines, mechatronics to the control and monitoring systems of machines. This conference is traditionally organised every four year under the auspices of the international organisation IFToMM and the Czech Society for Mechanics.

  19. Hydrodynamic Instability Experiments at the GEKKO XII/HIPER Laser

    Science.gov (United States)

    Azechi, Hiroshi; Nakai, Mitsuo; Shiraga, Hiroyuki; Miyanaga, Noriaki; Shigemori, Keisuke; Nishikino, Masaharu; Sakaiya, Tatsuro; Nishimura, Hiroaki; Fujita, Kazuhisa; Kang, Young-Gwang; Nagatomo, Hideo; Nishihara, Katsunobu; Yamanaka, Tatsuhiko

    2000-10-01

    We have constructed the HIPER laser system that combines all 12 beams of the existing GEKKO XII laser to irradiate a target from one side.The laser pulse in standard operation consists of partially coherent light for foot (green) and two-dimensional SSD for main drive (blue). We will test in the first series of experiment the ablation pressure and its uniformity, ablative Rayleigh-Taylor instability, and instability at explosion phase.\\x81@ Although the primary objective is to test hydrodynamic stability of an ignition target (both in fast ignition and conventional self-ignition), the HIPER laser is expected to be a major tool for a number of high energy-density physics, such as laboratory astrophysics, equation-of-state study.

  20. Uudised : Gennadi Tanieli autorikontsert. Tallinna XII barokifestival. Tubina ühing koguneb / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2001-01-01

    21. jaan. toimus sarjas "Eesti heliloojad talveaias" G. Tanieli autorikontsert. 1.-11. veebr. toimuvast Tallinna XII Barokkfestivalist. 27. jaan. toimub EMAs Rahvusvahelise Eduard Tubina Ühingu esimene aastakoosolek, koosoleku päevakorrast

  1. ANALISIS KESULITAN SISWA SMA DALAM PEMECAHAN MASALAH MATEMATIKA KELAS XII IPA DI KOTA YOGYAKARTA

    Directory of Open Access Journals (Sweden)

    Ayu Aji Wedaring Tias

    2015-05-01

    Full Text Available Penelitian ini bertujuan untuk mendeskripsikan letak kesulitan siswa yang dominan dan faktor-faktor kesulitan yang dialami siswa SMA dalam memecahkan masalah matematika. Penelitian ini termasuk penelitian deskriptif dengan pendekatan kuantitatif dan kualitatif. Subjek penelitian ini adalah 94 siswa SMA Negeri di Kota Yogyakarta yang berasal dari tiga sekolah dengan kategori tinggi, sedang, dan rendah. Pemilihan subjek penelitian dilakukan dengan stratified proportional random sampling. Pengumpulan data dilakukan dengan menggunakan dokumen, tes, dan wawancara. Analisis data dilakukan dengan metode analisis deskriptif kualitatif dengan pendekatan kuantitatif dan kualitatif yang memberikan gambaran mengenai letak dan faktor kesulitan siswa. Hasil penelitian menunjukkan bahwa kesulitan matematika siswa terletak pada kesulitan mengingat fakta 1,77%, kesulitan memahami fakta 3,54%, kesulitan menerapkan fakta 3,54%, kesulitan menganalisis fakta 10,18%, kesulitan mengingat konsep 1,33%, kesulitan memahami konsep 13,27%, kesulitan menerap-kan konsep 11,95%, kesulitan menganalisis konsep 4,42%, kesulitan memahami prosedur 7,52%, kesulitan menerapkan prosedur 15,49%, kesulitan menganalisis prosedur 16,37%, kesulitan mengingat konsep visual-spasial 1,33%, kesulitan memahami visual-spasial 3,54%, kesulitan menerapakan visual-spasial 3,10%, dan kesulitan menganalisis visual-spasial 2,65%. Faktor-faktor kesulitan yang dialami siswa SMA dalam memecahkan masalah matematika kelas XII program IPA yakni: siswa kurang teliti, tergesa-gesa dalam mengerjakan soal, lupa, kurang waktu untuk mengerjakan soal, cepat menyerah, terkecoh, dan cemas. Kata Kunci: analisis kesulitan, pemecahan masalah matematika, kemampuan pemecahan masalah   AN ANALYSIS OF SENIOR HIGH SCHOOL STUDENTS’ DIFFICULTIES IN MATHEMATICS PROBLEM SOLVING BASED AT GRADE XII OF SCIENCE PROGRAM IN YOGYAKARTA CITY Abstract This research aims to describe the locations of the difficulties and the factors

  2. Textos de compra-venta en el siglo XII

    Directory of Open Access Journals (Sweden)

    Marta Fernández Alcaide

    2008-06-01

    Full Text Available A partir del desarrollo del concepto de tradiciones discursivas, en los últimos años se ha realizado un estudio de textos del derecho del siglo XII, concretamente de unas actas de compra-venta. Estos documentos, aparentemente escritos en latín, ya presentan una sintaxis romance, muestra de la situación lingüística de la época, esa especie de bilingüismo diafásico entre el latín escrito y el romance hablado. Se empieza por un breve análisis fonológico, morfosintáctico y léxico, que ofrece una idea de las características lingüísticas del siglo. El objetivo del trabajo es el estudio de la estructura textual, facilitado por la escasa libertad de composición en este tipo de textos.---Based on the recent theoretical development of the discursive traditions, this article focuses on some law texts of the XIIth century, in particular, a few acts of purchase. These documents, apparently written in Latin, already display a Romance syntax. This depicts the linguistic situation of that time: some sort of dysphasic bilingualism between written Latin and spoken Romance. The article begins with phonological, morphological and lexical analyses that give a general idea of the characteristics of the language of the XIIth century. However, the objective of the present article is the study of the text structure, taking on consideration that there was not much room for creative display in this kind of documents.

  3. 76 FR 11191 - Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code

    Science.gov (United States)

    2011-03-01

    ... Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code AGENCY... Pressure Vessel Code, Section XII (2010 Edition) and the National Board of Boiler and Pressure Vessel Inspectors' National Board Inspection Code (2007 Edition). Further, PHMSA is extending the comment period...

  4. A Letter from Edmund Husserl to Franz Brentano from 29 XII 1889

    NARCIS (Netherlands)

    Ierna, Carlo

    2015-01-01

    Among the correspondence between Husserl and Brentano kept at the Houghton Library of Harvard University there is a letter from Husserl to Brentano from 29 XII 1889, whose contents were completely unknown until now. The letter is of some significance, both historically as well as systematically for

  5. High spatial resolution FeXII observations of solar active region

    CERN Document Server

    Testa, Paola; Hansteen, Viggo

    2016-01-01

    We use UV spectral observations of active regions with the Interface Region Imaging Spectrograph (IRIS) to investigate the properties of the coronal FeXII 1349.4A emission at unprecedented high spatial resolution (~0.33"). We find that by using appropriate observational strategies (i.e., long exposures, lossless compression), FeXII emission can be studied with IRIS at high spatial and spectral resolution, at least for high density plasma (e.g., post-flare loops, and active region moss). We find that upper transition region (moss) FeXII emission shows very small average Doppler redshifts (v_Dop ~3 km/s), as well as modest non-thermal velocities (with an average ~24 km/s, and the peak of the distribution at ~15 km/s). The observed distribution of Doppler shifts appears to be compatible with advanced 3D radiative MHD simulations in which impulsive heating is concentrated at the transition region footpoints of a hot corona. While the non-thermal broadening of FeXII 1349.4A peaks at similar values as lower resolut...

  6. A Letter from Edmund Husserl to Franz Brentano from 29 XII 1889

    NARCIS (Netherlands)

    Ierna, Carlo

    2015-01-01

    Among the correspondence between Husserl and Brentano kept at the Houghton Library of Harvard University there is a letter from Husserl to Brentano from 29 XII 1889, whose contents were completely unknown until now. The letter is of some significance, both historically as well as systematically for

  7. Transmembrane carbonic anhydrase isozymes IX and XII in the female mouse reproductive organs

    Directory of Open Access Journals (Sweden)

    Tomas Eija

    2004-10-01

    Full Text Available Abstract Background Carbonic anhydrase (CA classically catalyses the reversible hydration of dissolved CO2 to form bicarbonate ions and protons. The twelve active CA isozymes are thought to regulate a variety of cellular functions including several processes in the reproductive systems. Methods The present study was designed to investigate the expression of transmembrane CAs, CA IX and XII, in the mouse uterus, ovary and placenta. The expression of CA IX and XII was examined by immunoperoxidase staining method and western blotting. CA II and XIII served as positive controls since they are known to be present in the mouse reproductive tract. Results The data of our study indicated that CA XII is expressed in the mouse endometrium. Only very faint signal was observed in the corpus luteum of the ovary and the placenta remained mainly negative. CA IX showed weak reaction in the endometrial epithelium, while it was completely absent in the ovary and placenta. Conclusion The conservation of CA XII expression in both mouse and human endometrium suggests a role for this isozyme in reproductive physiology.

  8. 76 FR 75563 - Notice for Delay of Payment of Title XII Interest for Three States

    Science.gov (United States)

    2011-12-02

    ... October 1 for which data are available, the state had an average total unemployment rate of 13.5 percent... State of Nevada had requested delay of payment for accrued interest based on these high unemployment... Employment and Training Administration Notice for Delay of Payment of Title XII Interest for Three States...

  9. Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII.

    Science.gov (United States)

    Ibrahim, Hany S; Abou-Seri, Sahar M; Tanc, Muhammet; Elaasser, Mahmoud M; Abdel-Aziz, Hatem A; Supuran, Claudiu T

    2015-10-20

    New series of benzenesulfonamide derivatives incorporating pyrazole and isatin moieties were prepared using celecoxib as lead molecule. Biological evaluation of the target compounds was performed against the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and more precisely against the human isoforms hCA I, II (cytosolic), IX and XII (transmembrane, tumor-associated enzymes). Most of the tested compounds efficiently inhibited hCA I, II and IX, with KIs of 2.5-102 nM, being more effective than the reference drug acetazolamide. Compounds 11e, 11f, 16e and 16f were found to inhibit hCA XII with Ki of 3.7, 6.5, 5.4 and 7.2 nM, respectively. Compounds 11e and 16e, with 5-NO2 substitution on the isatin ring, were found to be selective inhibitors of hCA IX and hCA XII. Docking studies revealed that the NO2 group of both compounds participate in interactions with Asp132 within the hCA IX active site, and with residues Lys67 and Asp130 in hCA XII, respectively.

  10. The historical methodology of Anna Komnene: A case study of book XII chapter 3 of the Alexias

    Directory of Open Access Journals (Sweden)

    Inoue Koichi

    2015-01-01

    Full Text Available In this paper we examine Anna Komnene’s editorial procedure in Book XII chapter 3 of the Alexias and reappraise her historical methodology. We investigate the two dates at the end of XII.3.1, which are incompatible: the indiction does not correspond to the regnal year. Our investigations come to the following conclusions: Anna composes XII.3 using reliable sources, Alexios I’s official letters and court logbook; both of the dates originate in the trustworthy imperial documents that she consulted; the discrepancy between the two, commonly regarded as a mistake made by Anna, was caused by editorial work on the text after her death. As far as we can tell from XII.3, her method of historical composition is entirely clear and this suggests that the Alexias is a reliable historical source.

  11. The Mast Cell, Contact, and Coagulation System Connection in Anaphylaxis

    Directory of Open Access Journals (Sweden)

    Mar Guilarte

    2017-07-01

    Full Text Available Anaphylaxis is the most severe form of allergic reaction, resulting from the effect of mediators and chemotactic substances released by activated cells. Mast cells and basophils are considered key players in IgE-mediated human anaphylaxis. Beyond IgE-mediated activation of mast cells/basophils, further mechanisms are involved in the occurrence of anaphylaxis. New insights into the potential relevance of pathways other than mast cell and basophil degranulation have been unraveled, such as the activation of the contact and the coagulation systems. Mast cell heparin released upon activation provides negatively charged surfaces for factor XII (FXII binding and auto-activation. Activated FXII, the initiating serine protease in both the contact and the intrinsic coagulation system, activates factor XI and prekallikrein, respectively. FXII-mediated bradykinin (BK formation has been proven in the human plasma of anaphylactic patients as well as in experimental models of anaphylaxis. Moreover, the severity of anaphylaxis is correlated with the increase in plasma heparin, BK formation and the intensity of contact system activation. FXII also activates plasminogen in the fibrinolysis system. Mast cell tryptase has been shown to participate in fibrinolysis through plasmin activation and by facilitating the degradation of fibrinogen. Some usual clinical manifestations in anaphylaxis, such as angioedema or hypotension, or other less common, such as metrorrhagia, may be explained by the direct effect of the activation of the coagulation and contact system driven by mast cell mediators.

  12. Inhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds.

    Science.gov (United States)

    Petrou, Anthi; Geronikaki, Athina; Terzi, Emine; Guler, Ozen Ozensoy; Tuccinardi, Tiziano; Supuran, Claudiu T

    2016-12-01

    Carbonic anhydrases (CAs, EC 4.2.1.1) catalyze the fundamental reaction of CO2 hydration in all living organisms, being actively involved in the regulation of a plethora of patho/physiological conditions. A series of benzothiazole-based sulfonamides were synthesized and tested as possible CA inhibitors. Their inhibitory activity was assessed against the cytosolic human isoforms hCA I and hCA II and the transmembrane hCA IX and hCA XII. Several of the investigated derivatives showed interesting inhibition activity and selectivities for inhibiting hCA IX and hCA XII over the off-target ones hCA I and hCA II. Furthermore, computational procedures were used to investigate the binding mode of this class of compounds, within the active site of hCA IX.

  13. Ludus de Antichristo e o drama da escatologia imperial no século XII

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    Vinicius Cesar Dreger de Araújo

    2013-09-01

    Full Text Available Buscamos neste texto analisar as imbricações entre o texto teatral germânico do século XII, o Ludus de Antichristo, e o seu contexto político-cultural, particularmente em relação às personagens do Anticristo e do Último Imperador Romano, seus protagonistas, com a Escatologia Imperial encontrada no período. Nosso artigo contém um detalhado resumo da peça, estudos relacionados às tradições e documentos que levaram à sua concepção e seu enquadramento nos debates políticos e religiosos do século XII.

  14. ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI PRODUKTIVITAS KERJA PEMETIK TEH DI PTPN XII (PERSERO KEBUN WONOSARI

    Directory of Open Access Journals (Sweden)

    Ary Rahmady Pratama

    2015-09-01

    Full Text Available Produktivitas tenaga kerja merupakan hal yang penting bagi perusahaan. Peningkatan produktivitas kerja membuat pekerjaan lebih efektif dan efisien sehingga diperlukan dalam pencapaian tujuan yang telah ditetapkan perusahaan terutama dalam peningkatan produksi. Tujuan penelitian ini untuk mengetahui karakteristik umum karyawan khususnya tenaga kerja bagian pemetikan di PTPN XII (PERSERO Kebun Wonosari, menganalisis faktor-faktor yang signifikan dan paling dominan mempengaruhi produktivitas kerja pemetik di PTPN XII (PERSERO Kebun Wonosari. Analisis faktor-faktor yang mempengaruhi produktivitas tenaga kerja menggunakan analisis regresi linier berganda dengan menggunakan tujuh variabel (usia, pengalaman kerja, gaji, jaminan sosial, hubungan sesama pemetik, dan hubungan atasan bawahan sebagai variabel dependen dan variabel produktivitas tenaga kerja senagai variabel dependen. Hasil penelitian ini yaitu : Produktivitas tenaga kerja PTPN XII (PERSERO Kebun Wonosari pada setiap tenaga kerja berbeda tiap bulannya. Tenaga kerja yang termasuk kedalam golongan produktivitas rendah sebesar 30 orang responden dari 59 orang responden. Presentase pengaruh variabel independen seperti usia, pengalaman kerja, upah, jaminan sosial, hubungan sesama pemetik, hubungan atasan dan bawahan, jenis kelamin terhadap variabel dependen produktivitas tenaga kerja sebesar 93,8% atau variasi variabel independen yang digunakan dalam model mampu menjelaskan sebesar 93,8% variasi variabel dependen sedangkan sisanya sebesar 6,2% dipengaruhi atau dijelaskan oleh variabel lain di luar model. Faktor-faktor yang berpengaruh terhadap produktivitas kerja tenaga kerja adalah usia, pengalaman kerja, dan tingkat upah. Ketiga variabel tersebut berpengaruh pada taraf signifikansi alpha 5% dengan koefisien regresi masing-masing sebesar -0,79, 0,26 dan 0,54.

  15. Pengembangan Bahan Ajar Modul Elektrokimia untuk Siswa SMA Kelas XII IPA dengan Pendekatan Pembelajaran Inkuiri Terbimbing

    Directory of Open Access Journals (Sweden)

    Lilik Fatmawati

    2014-06-01

    Full Text Available Tujuan penelitian ini adalah mengetahui kelayakan, dan keefektifan modul elektrokimia un-tuk siswa SMA kelas XII hasil pengembangan. Modul Elektrokimia hasil pengembangan terdiri dari dua kegiatan belajar, yaitu untuk materi sel Volta dan untuk materi sel elektrolisis. Hasil penilaian oleh dua dosen kimia Universitas Negeri Malang dan dua guru kimia kelas XII sebagai ahli isi/materi pem-belajaran untuk kelayakan isi adalah 92,9%, untuk kelayakan dan kelengkapan penyajian adalah 91,1%, dan untuk kelayakan kebahasaan adalah 92,3%, yang tergolong kriteria sangat layak. Secara keseluruhan rata-rata nilai kelayakan tersebut adalah 92,1. Efektifitas modul hasil pengembangan di-tunjukkan oleh persepsi dan hasil belajar siswa. Persepsi siswa diperoleh dari penilaian siswa terhadap modul hasil pengembangan. Pada ujicoba lapangan terbatas diperoleh nilai rata-rata untuk seluruh aspek adalah 81,8 dari nilai maksimum 100. Perolehan rata-rata nilai hasil belajar siswa untuk aspek kognitif adalah 83,3, untuk aspek afektif adalah  82,3, dan untuk aspek psikomotorik adalah 83,8 dari nilai maksimum 100. Hasil keseluruhan penelitian menunjukkan bahwa Modul Elektrokimia untuk sis-wa SMA Kelas XII IPA hasil pengembangan sangat layak dan sangat efektif digunakan dalam proses pembelajaran.Kata kunci: inkuiri terbimbing, modul elektrokimia, model 4-D

  16. 2. XII möödus 20 aastat Adamson-Ericu muuseumi avamisest Eesti Kunstimuuseumi filiaalina ning 35 aastat Adamson-Ericu (1902-1968) surmast

    Index Scriptorium Estoniae

    2003-01-01

    Muuseumi ajaloost, põhikogust, Adamson-Ericu teoste põhiekspositsioonist, kunstinäitustest. 3. XII tutvustab Kersti Koll Adamson-Ericu ja läti kunstniku Ludolfs Libertsi näitust. 5. XII ekspositsioonis ringkäik "Meistri töövõtetest ning erinevatest materjalidest restauraatori pilgu läbi" Alar Nurkse juhtimisel, ekskursioon Ülle Kruusi juhtimisel. 10. XII algab projekti "Avatud muuseum" raames haridusprogramm "Noor kunstidetektiiv"

  17. 2. XII möödus 20 aastat Adamson-Ericu muuseumi avamisest Eesti Kunstimuuseumi filiaalina ning 35 aastat Adamson-Ericu (1902-1968) surmast

    Index Scriptorium Estoniae

    2003-01-01

    Muuseumi ajaloost, põhikogust, Adamson-Ericu teoste põhiekspositsioonist, kunstinäitustest. 3. XII tutvustab Kersti Koll Adamson-Ericu ja läti kunstniku Ludolfs Libertsi näitust. 5. XII ekspositsioonis ringkäik "Meistri töövõtetest ning erinevatest materjalidest restauraatori pilgu läbi" Alar Nurkse juhtimisel, ekskursioon Ülle Kruusi juhtimisel. 10. XII algab projekti "Avatud muuseum" raames haridusprogramm "Noor kunstidetektiiv"

  18. Factor XI and contact activation as targets for antithrombotic therapy.

    Science.gov (United States)

    Gailani, D; Bane, C E; Gruber, A

    2015-08-01

    The most commonly used anticoagulants produce therapeutic antithrombotic effects either by inhibiting thrombin or factor Xa (FXa) or by lowering the plasma levels of the precursors of these key enzymes, prothrombin and FX. These drugs do not distinguish between thrombin generation contributing to thrombosis from thrombin generation required for hemostasis. Thus, anticoagulants increase bleeding risk, and many patients who would benefit from therapy go untreated because of comorbidities that place them at unacceptable risk for hemorrhage. Studies in animals demonstrate that components of the plasma contact activation system contribute to experimentally induced thrombosis, despite playing little or no role in hemostasis. Attention has focused on FXII, the zymogen of a protease (FXIIa) that initiates contact activation when blood is exposed to foreign surfaces, and FXI, the zymogen of the protease FXIa, which links contact activation to the thrombin generation mechanism. In the case of FXI, epidemiologic data indicate this protein contributes to stroke and venous thromboembolism, and perhaps myocardial infarction, in humans. A phase 2 trial showing that reduction of FXI may be more effective than low molecular weight heparin at preventing venous thrombosis during knee replacement surgery provides proof of concept for the premise that an antithrombotic effect can be uncoupled from an anticoagulant effect in humans by targeting components of contact activation. Here, we review data on the role of FXI and FXII in thrombosis and results of preclinical and human trials for therapies targeting these proteins.

  19. Settlement, territory and notarial formulas: a verification (Verona, IX-XII century Insediamento, territorio e formule notarili: una verifica (Verona, IX-XII secolo

    Directory of Open Access Journals (Sweden)

    Andrea Brugnoli

    2011-10-01

    Full Text Available

    The organization of rural areas in early Middle Ages and its observability through techniques of location taken by notaries is a classic italian subject in the historiography in the second half of the 20th century. The documentation produced in Verona lend to a verify of the ipothesis and to the formulation of guidelines for the interpretation of this formulas as concerning settlement and village territory. The number of documents produced and preserved in Verona between 9th and 12th century, and its homogeneity as institutions which produced and trasmitted them, allows to deal with a complex analysis that must consider several others variables. On the hand of documentation it deals with the possible variety, up to personal practice, of notary’s formulas and uses; these are then linked on to differences on geographic patterns, ownership relations, landlords presence and agrarian practices. The variety of geographical context, equally divided between a hill of significant size, a dry and irrigated high plain and the lowlands subject to flood, is proposed as a positive element to identify different factors in the building of rural settlement, its organization and rapresentations. It is assumed that these formulas are developed into patterns resulting by a dialectic between notary’s culture and perception of the space organization, which should be the resulting in the relationship between human communities and the territory where these act. The aim is highlighting factors which were found to underlie the formation of village territories. This is the level more elusive and less considered by italian historiography that has traditionally focused on the jurisdictional (both landlord and ecclesiastical or fiscal one and therefore the relationship between power and territory. The comparative reading of location practice as a system of relations between the words – elaborated by a topographic level diachronic as

  20. "De grammaticorum schola" : La tradición cultural compostelana en el siglo XII

    OpenAIRE

    Rucquoi, Adeline

    2005-01-01

    Este artículo estudia el desarrollo de la escuela episcopal compostelana desde el siglo X y muestra cómo, a través del análisis de los textos producidos por sus componentes - el Codex Calixtinus, la Historia Compostellana, etc. -, se vislumbra la diversidad de las materias enseñadas y el cosmopolitismo que la caracterizó en el siglo XII.; Cet article s'attache au développement de l'école épiscopale compostellane depuis le Xe siècle, et montre comment l'analyse des textes qui y furent produits...

  1. Economic Reliability Acceptance Sampling Plans from Truncated Life Tests based on the Burr Type XII Percentiles

    Directory of Open Access Journals (Sweden)

    Abdur Razzaque Mughal (Corresponding Author

    2011-09-01

    Full Text Available In this article, economic reliability acceptance sampling plan (ERASP is developed for the Burr type XII distribution when the life test is truncated at pre-specified designed parameters. The minimum termination time is necessary to ensure that the specified life percentile is found under a given producer’s risk. The operating characteristic values of the proposed plan are presented for various parameters. A comparative study of proposedplan and existing plan developed by Lio et al. (2010 is also discussed. The result is illustrated by a real dataset example.

  2. Pedro Abelardo Professor: O Ensino de Filosofia no Século XII

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    Edsel Pamplona Diebe

    2014-09-01

    Full Text Available O artigo tem por objetivo apresentar o filósofo Pedro Abelardo (1079-1142 como professor, seu método de trabalho e a herança que recebeu da filosofia grega cristianizada. Em concomitância com o trabalho do Abelardo, mostraremos de forma introdutória o desenvolvimento do ensino de filosofia no século XII, o mundo escolar, artes liberais, a tentativa de conciliar fé e razão e o ensino da dialética.

  3. La scrittura delle carte bresciane del secolo XII

    Directory of Open Access Journals (Sweden)

    Martina Pantarotto

    2013-01-01

    Full Text Available Generally considered as the period in which a lot of factors (both within and outside the notarial practice made the gap between books and documents handwriting become narrower, and the influence of the former increased on the latter, 12th century was characterized also in Brescia by a shared adaptation of notaries' script to the ancient and prestigious model of littera antiqua. The new 'diplomatic minuscule', documented since the very first years of the century by excellent (though isolated cases (like the graphic experiences of iudex Ebezo and Rodulfus, became a widespread legacy among Brescia notaries in the mid-1150's. The papers aims at analyzing these graphical processes till to the resumption of a more cursive writing and the introduction of 'secondary' ligatures, that frankly foreshadow the most typical 13th century documentary script.

  4. Structure and function of transmembrane segment XII in osmosensor and osmoprotectant transporter ProP of Escherichia coli.

    Science.gov (United States)

    Liu, Feng; Culham, Doreen E; Vernikovska, Yaroslava I; Keates, Robert A B; Boggs, Joan M; Wood, Janet M

    2007-05-15

    Escherichia coli transporter ProP acts as both an osmosensor and an osmoregulator. As medium osmolality rises, ProP is activated and mediates H+-coupled uptake of osmolytes like proline. A homology model of ProP with 12-transmembrane (TM) helices and cytoplasmic termini was created, and the protein's topology was substantiated experimentally. Residues 468-497, at the end of the C-terminal domain and linked to TM XII, form an intermolecular, homodimeric alpha-helical coiled-coil that tunes the transporter's response to osmolality. We aim to further define the structure and function of ProP residues Q415-E440, predicted to include TM XII. Each residue was replaced with cysteine (Cys) in a histidine-tagged, Cys-less ProP variant (ProP*). Cys at positions 415-418 and 438-440 were most reactive with Oregon Green Maleimide (OGM), suggesting that residues 419 through 437 are in the membrane. Except for V429-I433, reactivity of those Cys varied with helical periodicity. Cys predicted to face the interior of ProP were more reactive than Cys predicted to face the lipid. The former may be exposed to hydrated polar residues in the protein interior, particularly on the periplasmic side. Intermolecular cross-links formed when ProP* variants with Cys at positions 419, 420, 422, and 439 were treated with DTME. Thus TM XII can participate, along its entire length, in the dimer interface of ProP. Cys substitution E440C rendered ProP* inactive. All other variants retained more than 30% of the proline uptake activity of ProP* at high osmolality. Most variants with Cys substitutions in the periplasmic half of TM XII activated at lower osmolalities than ProP*. Variants with Cys substitutions on one face of the cytoplasmic half of TM XII required a higher osmolality to activate. They included elements of a GXXXG motif that are predicted to form the interface of TM XII with TM VII. These studies define the position of ProP TM XII within the membrane, further support the predicted

  5. Implosion and heating experiments of fast ignition targets by Gekko-XII and LFEX lasers

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    Shiraga H.

    2013-11-01

    Full Text Available The FIREX-1 project, the goal of which is to demonstrate fuel heating up to 5 keV by fast ignition scheme, has been carried out since 2003 including construction and tuning of LFEX laser and integrated experiments. Implosion and heating experiment of Fast Ignition targets have been performed since 2009 with Gekko-XII and LFEX lasers. A deuterated polystyrene shell target was imploded with the 0.53- μm Gekko-XII, and the 1.053- μm beam of the LFEX laser was injected through a gold cone attached to the shell to generate hot electrons to heat the imploded fuel plasma. Pulse contrast ratio of the LFEX beam was significantly improved. Also a variety of plasma diagnostic instruments were developed to be compatible with harsh environment of intense hard x-rays (γ rays and electromagnetic pulses due to the intense LFEX beam on the target. Large background signals around the DD neutron signal in time-of-flight record of neutron detector were found to consist of neutrons via (γ,n reactions and scattered gamma rays. Enhanced neutron yield was confirmed by carefully eliminating such backgrounds. Neutron enhancement up to 3.5 × 107 was observed. Heating efficiency was estimated to be 10–20% assuming a uniform temperature rise model.

  6. HUBUNGAN ANTARA KUALITAS KEHIDUPAN SEKOLAH DENGAN KEDISIPLINAN SISWA KELAS BERPINDAH PADA KELAS XII SMAN 3 SEMARANG

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    Nada Febriani

    2013-10-01

    Full Text Available Purpose of this study was to determine the relationship between quality of school life with student's discipline of moving class at students class XII SMAN 3 Semarang. Quality of school life is students perception about dimensional of school, including student perspective towards their school, the connection with teachers, feeling that student will achieve success in school, the student chance to face future, social integration, and exlporing. Student's discipline is the meaning of their willingness to obey all regulation in their school. The subject of this study was 301 students of moving class at students class XII SMAN 3 Semarang. Cluster random sampling is used. Technique of data collection used the discipline scale (30 aitem valid α=0,915 and the scale of quality of school life (31 aitem valid α=0,925. Based on the analysis of simple regression showed rxy = 0.520 with p=0.000 (p<0.05. This results indicate that the proposed hypothesis, the existance of a relationship between quality of school life with student's discipline of moving class. Positive coefficient correlation value indicate more positive quality of school life, the higher discipline, and vice versa. Effective quality of school life contributes 27.1% on discipline and 72.9 % were influenced by others. Keywords: Student's Discipline, quality of school life, moving class

  7. Si XII X-ray Satellite Lines in Solar Flare Spectra

    Science.gov (United States)

    Phillips, K. J.; Sylwester, J.; Sylwester, B.; Dubau, J.

    2005-05-01

    We demonstrate the temperature dependence of the intensity ratio of dielectronic satellite lines due to Li-like Si (Si XII) to nearby He-like Si (Si XIII) 1s2 - 1snp(n=3, 4, 5) lines emitted in solar flare X-ray spectra. These lines, which occur in the wavelength range 5.253~Å--5.818~Å, have been observed by the RESIK bent crystal spectrometer on the Russian CORONAS-F solar mission. Line features made up of several strong satellites with transitions 1s2 n'l' - 1s n'l' nl lie near the `parent' Si XIII lines, transition 1s2 1S0 - 1snp 1P1; thus, the feature at 5.818~Å is made up of several blended Si XII satellites with `spectator' electrons n'l'=2s or 2p and nl=3p or 3d, and lies on the long-wavelength side of the Si XIII 1s2 - 1s3p line at 5.681~Å. A similar n=4 satellite feature at 5.565~Å is on the long-wavelength side of the Si XIII 1s2 - 1s4p line at 5.384~Å. The Si XII satellites are formed by dielectronic recombination and direct (inner-shell) excitation. The ratio Is/IHe (Is = Si XII satellite line flux, IHe = Si XIII line flux) depends on electron temperature approximately as Te-1. The atomic data needed to calculate Is/IHe for individual n=3 and n=4 Si XII satellite lines have been calculated and will be presented in this paper; excitation mechanisms including those by dielectronic recombination and inner-shell excitation were included using the SUPERSTRUCTURE and Distorted Wave formalisms. With these and theoretical fluxes of the Si XIII lines, synthetic spectra were calculated and compared with RESIK solar flare spectra. Values of Is/IHe measured from RESIK spectra during the decay of four long-duration solar flares, together with temperatures estimated both from the ratio of the GOES channels and from the ratio of total fluxes in two of the four RESIK channels, enable a comparison to be made with theoretical curves. The agreement with the theoretical curve based on synthetic spectra is within expected uncertainties, and the Te-1 dependence is

  8. Characterization and Sequencing of a Genotype XII Newcastle Disease Virus Isolated from a Peacock (Pavo cristatus) in Peru

    Science.gov (United States)

    Tataje-Lavanda, Luis; Figueroa, Aling; Segovia, Karen; Gonzalez, Rosa; Cribillero, Giovana; Montalvan, Angela; Fernández-Díaz, Manolo; Icochea, Eliana

    2015-01-01

    Here, we report the first complete sequence and biological characterization of a Newcastle disease virus (NDV) isolated from a peacock in South America (NDV/peacock/Peru/2011). This isolate, classified as genotype XII in class II, highlights the need for increased surveillance of noncommercial avian species. PMID:26227592

  9. 78 FR 79363 - Hazardous Materials: Adoption of ASME Code Section XII and the National Board Inspection Code

    Science.gov (United States)

    2013-12-30

    ... tank. Manufacturers will only elect to utilize Section XII if it makes business sense. II...'s compliance and enforcement programs. Within the United States, the most common modes of... practices, improved materials, advances in welding, examination and testing. Notably, fracture mechanics did...

  10. Contact activation of blood-plasma coagulation

    Science.gov (United States)

    Golas, Avantika

    Surface engineering of biomaterials with improved hemocompatibility is an imperative, given the widespread global need for cardiovascular devices. Research summarized in this dissertation focuses on contact activation of FXII in buffer and blood plasma frequently referred to as autoactivation. The extant theory of contact activation imparts FXII autoactivation ability to negatively charged, hydrophilic surfaces. According to this theory, contact activation of plasma involves assembly of proteins comprising an "activation complex" on activating surfaces mediated by specific chemical interactions between complex proteins and the surface. This work has made key discoveries that significantly improve our core understanding of contact activation and unravel the existing paradigm of plasma coagulation. It is shown herein that contact activation of blood factor XII (FXII, Hageman factor) in neat-buffer solution exhibits a parabolic profile when scaled as a function of silanized-glass-particle activator surface energy (measured as advancing water adhesion tension t°a=g° Iv costheta in dyne/cm, where g°Iv is water interfacial tension in dyne/cm and theta is the advancing contact angle). Nearly equal activation is observed at the extremes of activator water-wetting properties --36 < t°a < 72 dyne/cm (O° ≤ theta < 120°), falling sharply through a broad minimum within the 20 < t°a < 40 dyne/cm (55° < theta < 75°). Furthermore, contact activation of FXII in buffer solution produces an ensemble of protein fragments exhibiting either procoagulant properties in plasma (proteolysis of blood factor XI or prekallikrein), amidolytic properties (cleavage of s-2302 chromogen), or the ability to suppress autoactivation through currently unknown biochemistry. The relative proportions of these fragments depend on activator surface chemistry/energy. We have also discovered that contact activation is moderated by adsorption of plasma proteins unrelated to coagulation through an

  11. Arquitectura de las órdenes militares en Aragón (siglos XII-XIV)

    OpenAIRE

    González Arracó, María del Carmen; Galtier Martí, Fernando

    2012-01-01

    Estudio de los edificios conservados en Aragón que pertenecieron a las Órdenes Militares del Temple,San Juan de Jerusalén, Calatrava y Santiago, construidos durante los siglos XII a XIV. La estructura de la tesis comprende: una introducción histórica sobre las Cruzadas, la creación de las respectivas Órdenes y una visión global de alguno de sus edificios más importantes en Tierra Santa; su introducción en Europa y en España con la consecuente fundación de las Órdenes Militares Hispánicas; un ...

  12. Investidura de armas de los reyes españoles en los siglos XII y XIII

    Directory of Open Access Journals (Sweden)

    Palacios Martín, Bonifacio

    1988-12-01

    Full Text Available Este trabajo quiere ser una primera aproximación a uno de los temas más apasionantes para la simbologia política medieval: la investidura de armas del rey en la España cristiana de los siglos XII y XIII. El tema tiene todas las dificultades propias de los estudios de simbologia, que se acrecientan cuando se trata de simbologia política y más aún cuando se interfieren —como en este caso— conceptos caballerescos. Precisa entonces de unos planteamientos muy amplios que atiendan, por una parte, a la evolución pluriforme del acto de investidura, y por otra, al contexto sociopolitico en el que ésta se produce, a fin de captar los matices y circunstancias que inciden en su significado.

  13. Le carte del monastero di S. Maria di Chiaravalle milanese. Additiones documentarie (secolo XII

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    Maria Cristina Piva

    2013-01-01

    Full Text Available Founded in 1135 in the immediate outskirts of Milan, Cistercian monastery of S. Maria di Chiaravalle was one of the most important ecclesiastical institutions in Lombardy. Since its foundation, it has played a prominent role in the political, religious, social and economic life of the city. In the Middle Ages the abbey distinguished itself with intensive production and preservation of documents, exemplified nowadays by the several hundreds of charterse preserved in the Archivio di Stato of Milan. This research aims to complete the organic reconstruction work, recently carried out by Anna Maria Rapetti and Ada Grossi regarding the XII century tabularium of Chiaravalle, with the critical edition of 28 unreleased documents dated between 1106 and 1164. In the introduction, in addition to the presentation of the documents, a paragraph will outline the historiographical balance of the studies conducted so far on the abbey.

  14. Unmelted Meteoritic Debris Collected from Eltanin Ejecta in Polarstern Cores from Expedition ANT XII/4

    Science.gov (United States)

    Kyte, Frank T.

    2002-01-01

    A total of 1.7g of unmelted meteorite particles have been recovered from FS Polarstern piston cores collected on expedition ANT XII/4 that contain ejecta from the Eltanin impact event. Most of the mass (1.2 g) is a large, single specimen that is a polymict breccia, similar in mineralogy and chemistry to howardites or the silicate fraction of mesosiderites. Most of the remaining mass is in several large individual pieces (20-75mg each) that are polymict breccias, fragments dominated by pyroxene, and an igneous rock fragment. The latter has highly fractionated REE, similar to those reported in mafic clasts from mesosiderites. Other types of specimens identified include fragments dominated by maskelynite or olivine. These pieces of the projectile probably survived impact by being blown off the back surface of the Eltanin asteroid during its impact into the Bellingshausen Sea.

  15. KETERAMPILAN MENULIS KREATIF CERPEN MENGGUNAKAN MEDIA AUDIO SISWA KELAS XII SMAN 1 KECAMATAN PAYAKUMBUH

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    Wirda Linda

    2017-04-01

    Full Text Available Writing skills is activities of language serves to produce  written language. Writing can improve intelligence, develop initiative, creativity,, stimulate the willingness and ability to gather information. Students' skills in short stories writing activities is still lacking. This things because teachers use less attractive media. Thus, this study uses audio media to increase students' interest in writing. This study aimed to describe the shost story intrinsic elements and the use of capital letters in Creative Short Story Writing Skills Using Media Audio Class XII SMAN I Payakumbuh District.This research is a quantitative research using descriptive method. The study population class XII students totaling 217 consists of 8 classes. Writer to perform sampling with random random sampling techniques. The instrument of this study is to test performance. Data analysis  in the study: to check the results to write short stories, analyze the data and provide a score based on indicators, and put forward the test results to the classification skills by using a scale of 10.Results showed that  average value of 90.8 are in the range of 86-95% with good qualification. Creative writing skills are evaluated from two short stories specified indicators are: (1 short story creative writing skills in terms of the intrinsic elements of the short story is the 100 that are in the range of 96-100% with impeccable qualifications; (2 The short story creative writing skills in terms of capitalization was 80.8% are in the 76-85 range with good qualifications. Thus, we can conclude the students are already capable in writing short stories as well as the use of capital letters in writing.    

  16. Alfonso XII y el turno sin pacto : prerrogativa regia y práctica parlamentaria

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    Angeles Lario

    1998-01-01

    Full Text Available Alfonso XII era un Rey considerado extremadamente liberal, él mismo se presentó como no creyente, y con la ambición de ser un Rey verdaderamente constitucional. La primera llegada de los Liberales, en 1881, considerada tradicionalmente como el primer ejemplo de turno pacífico entre los partidos, fue fruto de la decisión del Rey de cambiar de política, después de seis años de Gobierno conservador. Cánovas, sin embargo, no había encontrado todavía el modo de proceder a un turno pacífico entre los partidos, que fue forzado por el monarca, y que obligó al ¡efe conservador a provocar la caída de ese Gobierno por todos los medios: no había todavía mecanismo alguno para hacer salir a un Gobierno del poder y se podía volver al exclusivismo.Politics and analyst of his time, thought Alfonso XII was a very liberal King. He wrote thas he wasn't as much catholic as this ancestors. He wanted to be a true constitutional King. The first Government of Liberal Party, in 1881, was a King's decisión, after six years of Conservative Government. Cánovas was doubtful about wich way the crisis should be resolved, and he tried all posibilities for carry Sagasta out of power: The «pacto» still don't working.

  17. Dynamics enhanced by HCl doping triggers full Pauling entropy release at the ice XII-XIV transition

    Science.gov (United States)

    Köster, K. W.; Fuentes-Landete, V.; Raidt, A.; Seidl, M.; Gainaru, C.; Loerting, T.; Böhmer, R.

    2015-06-01

    The pressure-temperature phase diagram of ice displays a perplexing variety of structurally distinct phases. In the century-long history of scientific research on ice, the proton-ordered ice phases numbered XIII through XV were discovered only recently. Despite considerable effort, none of the transitions leading from the low-temperature ordered ices VIII, IX, XI, XIII, XIV and XV to their high-temperature disordered counterparts were experimentally found to display the full Pauling entropy. Here we report calorimetric measurements on suitably high-pressure-treated, hydrogen chloride-doped ice XIV that demonstrate just this at the transition to ice XII. Dielectric spectroscopy on undoped and on variously doped ice XII crystals reveals that addition of hydrogen chloride, the agent triggering complete proton order in ice XIV, enhances the precursor dynamics strongest. These discoveries provide new insights into the puzzling observation that different dopants trigger the formation of different proton-ordered ice phases.

  18. Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD.

    Science.gov (United States)

    Slepchenko, Sergey Mikhailovich; Gusev, Alexander Vasilevich; Ivanov, Sergey Nikolaevich; Svyatova, Evgenia Olegovna

    2015-12-01

    We present a paleoparasitological analysis of the medieval Zeleniy Yar burial ground of the XII-XII centuries AD located in the northern part of Western Siberia. Parasite eggs, identified as eggs of Opisthorchis felineus, were found in the samples from the pelvic area of a one year old infant buried at the site. Presence of these eggs in the soil samples from the infant's abdomen suggests that he/she was infected with opisthorchiasis and imply consumption of undercooked fish. Ethnographic records collected among the population of the northern part of Western Siberia reveal numerous cases of feeding raw fish to their children. Zeleniy Yar case of opisthorchiasis suggests that this dietary custom has persisted from at least medieval times.

  19. Opisthorchiasis in infant remains from the medieval Zeleniy Yar burial ground of XII-XIII centuries AD

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    Sergey Mikhailovich Slepchenko

    2015-01-01

    Full Text Available We present a paleoparasitological analysis of the medieval Zeleniy Yar burial ground of the XII-XII centuries AD located in the northern part of Western Siberia. Parasite eggs, identified as eggs of Opisthorchis felineus, were found in the samples from the pelvic area of a one year old infant buried at the site. Presence of these eggs in the soil samples from the infant’s abdomen suggests that he/she was infected with opisthorchiasis and imply consumption of undercooked fish. Ethnographic records collected among the population of the northern part of Western Siberia reveal numerous cases of feeding raw fish to their children. Zeleniy Yar case of opisthorchiasis suggests that this dietary custom has persisted from at least medieval times.

  20. Kinetic and thermodynamic characterization of the interactions between the components of human plasma kinin-forming system and isolated and purified cell wall proteins of Candida albicans.

    Science.gov (United States)

    Seweryn, Karolina; Karkowska-Kuleta, Justyna; Wolak, Natalia; Bochenska, Oliwia; Kedracka-Krok, Sylwia; Kozik, Andrzej; Rapala-Kozik, Maria

    2015-01-01

    Cell wall proteins of Candida albicans, besides their best known role in the adhesion of this fungal pathogen to host's tissues, also bind some soluble proteins, present in body fluids and involved in maintaining the biochemical homeostasis of the human organism. In particular, three plasma factors - high-molecular-mass kininogen (HK), factor XII (FXII) and prekallikrein (PPK) - have been shown to adhere to candidal cells. These proteins are involved in the surface-contact-catalyzed production of bradykinin-related peptides (kinins) that contribute to inflammatory states associated with microbial infections. We recently identified several proteins, associated with the candidal cell walls, and probably involved in the binding of HK. In our present study, a list of potential FXII- and PPK-binding proteins was proposed, using an affinity selection (on agarose-coupled FXII or PPK) from a whole mixture of β-1,3-glucanase-extrated cell wall-associated proteins and the mass-spectrometry protein identification. Five of these fungal proteins, including agglutinin-like sequence protein 3 (Als3), triosephosphate isomerase 1 (Tpi1), enolase 1 (Eno1), phosphoglycerate mutase 1 (Gpm1) and glucose-6-phosphate isomerase 1 (Gpi1), were purified and characterized in terms of affinities to the human contact factors, using the surface plasmon resonance measurements. Except Gpm1 that bound only PPK, and Als3 that exhibited an affinity to HK and FXII, the other isolated proteins interacted with all three contact factors. The determined dissociation constants for the identified protein complexes were of 10(-7) M order, and the association rate constants were in a range of 10(4)-10(5) M(-1)s(-1). The identified fungal pathogen-host protein interactions are potential targets for novel anticandidal therapeutic approaches.

  1. Electron-ion Recombination of Fe XII forming Fe XI: Laboratory Measurements and Theoretical Calculations

    CERN Document Server

    Novotný, O; Bernhardt, D; Grieser, M; Hahn, M; Krantz, C; Lestinsky, M; Müller, A; Repnow, R; Schippers, S; Wolf, A; Savin, D W

    2012-01-01

    We have measured electron-ion recombination for Fe XII forming Fe XI using a merged beams configuration at the heavy-ion storage ring TSR located at the Max Planck Institute for Nuclear Physics in Heidelberg, Germany. The measured merged beams recombination rate coefficient (MBRRC) for collision energies from 0 to 1500 eV is presented. This work uses a new method for determining the absolute MBRRC based on a comparison of the ion beam decay rate with and without the electron beam on. For energies below 75 eV, the spectrum is dominated by dielectronic recombination (DR) resonances associated with 3s-3p and 3p-3d core excitations. At higher energies we observe contributions from 3-N' and 2-N' core excitations DR. We compare our experimental results to state-of-the-art multi-configuration Breit-Pauli (MCBP) calculations and find significant differences, both in resonance energies and strengths. We have extracted the DR contributions from the measured MBRRC data and transformed them into a plasma recombination ra...

  2. Vivere «secundum Langnobardorum legem» ad Ariano Irpino tra X e XII secolo

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    Paola Massa

    2015-01-01

    Full Text Available The study examines a dossier of 51 notarial documents, produced between Xth and XIIth centuries, mostly coming from the ancient archive of St. Michele Arcangelo monastery in Ariano Irpino (Benevento, to trace the notary development in a peripheral center of Campanian hinterland. It arises as a continuation of the previous essay Prassi giuridica e pratiche di documentazione in carte inedite di Ariano Irpino dall’XI e XII secolo, in «Nuovi Annali della Scuola Speciale per Archivisti e Bibliotecari», 24 (2010, pp. 7-26. The documents, preserved in different locations (Archive of Montevergine Abbey, Museo del Sannio in Benevento, private Archive of Aldobrandini family in Frascati and the Vatican Library, constitute the platform on which it focuses the historical, paleographical and diplomatic exegesis. The edition of 19 charters (15 of them still unpublished, together with the analysis of the other documents, allowed to observe on the one hand the coexistence of conservative attitudes related to the tradition with symptoms of change in negotial patterns and documentary system in a restricted area, even if well connected to Benevento, the capital of the Lombard Principality, and on the other hand to bring out the steps of a slow but refined process of professional identity achievement pursued by notaries and judges, working together to construct a constantly evolving documentary practice.

  3. Identidad de las hospitalarias en la corona de Aragón (siglos XII-XIII

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    Maria Bonet Donato

    2014-12-01

    Full Text Available La rama femenina del Hospital fue singular en el seno de la institución y logró una autonomía y una entidad diferenciadora que se manifestó y consolidó en la afirmación de elementos identitarios. La identidad de las hospitalarias se concretó en la reivindicación y el despliegue de funciones y actividades singulares, en la existencia de mujeres carismáticas que encarnaron dicha identidad y en el reconocimiento de ciertos espacios. Las comunidades de monjas hospitalarias de la corona de Aragón en los siglos XII y XIII se caracterizaron por una diferenciación entre ellas mayor que la que se dio entre las encomiendas masculinas, y a su vez tuvieron mayor individualización en el contexto institucional. Las hospitalarias expresaron su espiritualidad y lograron visibilidad y protagonismo social, conforme a la creación o recreación de la identidad hospitalaria. Dicha identidad femenina hospitalaria resultó de la combinación de aspectos concernientes a la identidad familiar, femenina, espiritual, religiosa, individual, política, y se acomodó a la “personalidad” de cada entidad conventual, e inclusive a la de algunas figuras con destacado liderazgo

  4. Gambaran Strategi Coping Stress Siswa Kelas XII Sman 42 Jakarta dalam Menghadapi Ujian Nasional

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    Muhamad Nanang Suprayogi

    2011-04-01

    Full Text Available This study intended to know the description of stress coping strategies of 12th grade students of Jakarta 42 State Senior High School in facing National Exam. This study stems from the interest of researchers towards the number of cases of high school students who do not pass the National Exam. Researchers seek to impart knowledge to students on how to cope with their stress effectively and to the school and parents for providing the proper approach for students to face the National Exam. This study is a quantitative study using questionnaires as a measurement to know the description of stress coping strategies of Jakarta 42 State Senior High School students. Research instruments are compiled based on the theory developed by Lahey. In this research, obtained results that the class XII students of SMAN 42 Jakarta have a more predominant use of effective coping to cope with their stress in facing the National Exam. The most widely used strategy is removing stress and managing stress reaction  

  5. Historia reciente: XII Congreso Internacional del Cáncer, Buenos Aires, Argentina, 1978

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    Hugo Spinelli

    2014-01-01

    Full Text Available Desde los enfoques de la historia del tiempo presente, este artículo recupera la discusión en torno al XII Congreso Internacional del Cáncer realizado en Buenos Aires en 1978, que provocó la realización en París de un “contracongreso” por iniciativa de Georges Périès. Para ello se describe el escenario político de la época, la situación de los derechos humanos en Argentina, el rol de los medios de comunicación, en especial los periódicos La Nación y Clarín y la revista Gente, y la posición institucional adoptada por la Academia Nacional de Medicina, plasmada en una carta enviada a los presiden- tes de las principales sociedades científicas del mundo, que se reproduce como fuente documental, tomada del libro Memoria: Año 1978 (Presidencia de Dr. José E. Rivarola. El marco de la discusión remite a la política social de la ciencia versus su presunta neu- tralidad y el rol de las sociedades científicas.

  6. Establishment of reference intervals for von Willebrand factor antigen and eight coagulation factors in a Korean population following the Clinical and Laboratory Standards Institute guidelines.

    Science.gov (United States)

    Jang, Ja-Hyun; Seo, Ja-Young; Bang, Sung-Hwan; Park, In-Ae; Kim, Hee-Jin; Kim, Sun-Hee

    2010-04-01

    Establishment of reference intervals for coagulation molecules is important but is costly and sometimes not feasible. Since reference intervals from manufacturers or the literature are mostly out of date or involved Western populations, the authors determined reference intervals for VWF: Ag and eight factors in a Korean population. VWF: Ag, factor VIII (FVIII), FII, FV, FVII, FIX, FX, FXI, and FXII were determined in Korean individuals visiting for routine checkup following the CLSI (Clinical and Laboratory Standards Institute) guidelines. Reagents by Diagnostica Stago were used on the STA Compact Analyzer (Diagnostica Stago). Exclusion criteria were medical history or laboratory findings that could affect the factor levels. Influence of demographic factors was analyzed. Mean +/- 2 x SD or central 95 percentile was used, as appropriate. We obtained data from 266 adults for VWF: Ag, 371 adults for FVIII, and minimum 136 adults for the rest. Reference interval for VWF was 51-176% (52-155% in blood group O and 71-186% for non-O). Reference interval for FVIII was 64-197% (55-150% in O and 77-205% in non-O). Reference interval for FII was 77-121%, FV 81-160%, FVII 68-149%, FIX 67-154%, FX 69-126%, FXI 59-138%, and FXII 48-177%. The medians of VWF: Ag, FVIII, and FIX were significantly higher in the elderly group (> or =60 years). We established local reference intervals for VWF: Ag and eight coagulation factors in a Korean population according to the CLSI guidelines. Significantly, different reference intervals were obtained in blood group O vs. non-O for VWF: Ag and FVIII. The reference intervals obtained in this study could be adopted in other clinical laboratories after appropriate validation.

  7. PENGARUH MOTIVASI BELAJAR EKONOMI, GENDER DAN LINGKUNGAN PONDOK PESANTREN (SUNAN PANDANARAN TERHADAP PERILAKU BELAJAR EKONOMI SISWA DI KELAS PADA SISWA KELAS XII IPS PUTRA DAN XII IPS PUTRI MA SUNAN PANDANARAN SLEMAN, YOGYAKARTA

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    Siti Masruroh

    2015-11-01

    Full Text Available Penelitian ini bertujuan untuk menguji pengaruh motivasi belajar ekonomi, gender dan lingkungan pondok pesantren (Sunan Pandanaran terhadap perilaku belajar ekonomi siswa di kelas baik secara simultan maupun parsial. Populasi dan sampel pada penelitian ini adalah siswa kelas XII IPS Putra dan siswi kelas XII IPS Putri. Metode pengumpulan data dalam penelitian ini menggunakan metode angket/kuesioner. Variabel dependen pada penelitian ini yaitu perilaku belajar ekonomi siswa di kelas. Variabel independennya yaitu motivasi belajar ekonomi, gender dan lingkungan pondok pesantren (Sunan Pandanaran. Hasil uji hipotesis simultan menunjukkan bahwa ada pengaruh motivasi belajar ekonomi, gender dan lingkungan pondok pesantren (Sunan Pandanaran terhadap perilaku belajar ekonomi siswa di kelas. Hasil uji hipotesis secara parsial menunjukkan bahwa ada pengaruh motivasi belajar ekonomi terhadap perilaku belajar ekonomi siswa di kelas, ada pengaruh gender terhadap perilaku belajar ekonomi siswa di kelas dan ada pengaurh lingkungan pondok pesantren (Sunan Pandanaran terhadap perilaku belajar ekonomi siswa di kelas. Simpulan dari penelitian ini yaitu motivasi belajar ekonomi, gender dan lingkungan pondok pesantren (Sunan Pandanaran berpengaruh terhadap perilaku belajar ekonomi siswa di kelas baik secara simultan maupun secara parsial. Untuk penelitian selanjutnya diharapkan dapat menggunakan variabel lain yang tidak digunakan dalam penelitian ini seperti minat terhadap mata pelajaran ekonomi dan dukungan orang tua yang secara parsial maupun simultan dapat berpengaruh terhadap perilaku belajar ekonomi siswa di kelas. This study aimed to examine the effect of learning motivation economic, gender and environmental Boarding Sunan Pandanaran the behavior of students in the classroom studying economics either simultaneously or partially. Population and sample in this research were students of class XII IPS grader son and daughter XII IPS. Data collection method in

  8. Pathotyping and Phylogenetic Characterization of Newcastle Disease Viruses Isolated in Peru: Defining Two Novel Subgenotypes Within Genotype XII.

    Science.gov (United States)

    Chumbe, Ana; Izquierdo-Lara, Ray; Tataje, Luis; Gonzalez, Rosa; Cribillero, Giovana; González, Armando E; Fernández-Díaz, Manolo; Icochea, Eliana

    2017-03-01

    Infections of poultry with virulent strains of avian paramyxovirus 1 (APMV-1), also known as Newcastle disease viruses (NDVs), cause Newcastle disease (ND). This highly contagious disease affects poultry and many other species of birds worldwide. In countries where the disease is prevalent, constant monitoring and characterization of isolates causing outbreaks are necessary. In this study, we report the results of pathogenicity testing and phylogenetic analyses of seven NDVs isolated from several regions of Peru between 2004 and 2015. Six viruses had intracerebral pathogenicity indices (ICPIs) of between 1.75 and 1.88, corresponding to a velogenic pathotype. The remaining virus had an ICPI of 0.00, corresponding to a lentogenic pathotype. These results were consistent with amino acid sequences at the fusion protein (F) cleavage site. All velogenic isolates had the polybasic amino acid sequence (112)RRQKR↓F(117) at the F cleavage site. Phylogenetic analyses of complete F gene sequences showed that all isolates are classified in class II of APMV-1. The velogenic viruses are classified in genotype XII, while the lentogenic virus is classified in genotype II, closely related to the LaSota vaccine strain. Moreover, tree topology, bootstrap values, and genetic distances observed within genotype XII resulted in the identification of novel subgenotypes XIIa (in South America) and XIIb (in China) and possibly two clades within genotype XIIa. All velogenic Peruvian viruses belonged to subgenotype XIIa. Overall, our results confirm the presence of genotype XII in Peru and suggest that it is the prevalent genotype currently circulating in our country. The phylogenetic characterization of these isolates helps to characterize the evolution of NDV and may help with the development of vaccines specific to our regional necessities.

  9. EFEKTIFITAS LAYANAN BIMBINGAN KELOMPOK UNTUK MENGATASI PERILAKU MEMBOLOS SISWA KELAS XII IPS-1 SMA 1 GEBOG TAHUN PELAJARAN 2014/2015

    Directory of Open Access Journals (Sweden)

    Musafiroh -

    2015-11-01

    Full Text Available Penelitian ini dilatarbelakangi oleh fenomena membolos pada siswa kelas XII IPS-1 SMA 1 Gebog Tahun Pelajaran 2014/2015. Tujuan penelitian ini adalah mendeskripsikan efektifitas layanan bimbingan kelompok untuk mengatasi perilaku membolos siswa kelas XII IPS I SMA 1 Gebog Kudus Tahun 2014/2015. Hasil observasi awal menunjukkan ada 8 siswa yang terindikasi berperilaku membolos sangat tinggi. Penelitian ini dirancang dalam dua siklus dimana masing-masing siklus diadakan empat kali pertemuan. Hasil penelitian menunjukkan bahwa survei awal membolos siswa kelas XII IPS 1 SMA 1 Gebog sangat tinggi yaitu rata-rata skor 47,38, setelah diberi layanan Bimbingan Kelompok pada siklus I hasil skor rata-rata 26,13 dalam kategori cukup. Karena hasilnya belum maksimal maka dilakukan Bimbingan Kelompok siklus II dengan tujuan mengatasi membolos siswa menjadi rendah menjadi rata-rata skor 18,13. Sehingga hipotesis tindakan diterima karena teruji kebenarannya.

  10. Geothermal Program Review XII: proceedings. Geothermal Energy and the President's Climate Change Action Plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-12-31

    Geothermal Program Review XII, sponsored by the Geothermal Division of US Department of Energy, was held April 25--28, 1994, in San Francisco, California. This annual conference is designed to promote effective technology transfer by bringing together DOE-sponsored researchers; utility representatives; geothermal energy developers; suppliers of geothermal goods and services; representatives from federal, state, and local agencies; and others with an interest in geothermal energy. In-depth reviews of the latest technological advancements and research results are presented during the conference with emphasis on those topics considered to have the greatest potential to impact the near-term commercial development of geothermal energy.

  11. Gestos, mapas y colores del silencio : estudio comparativo en literatura, arte y pensamiento, siglos XII-XX

    OpenAIRE

    Labraña Cortés, Marcela Andrea

    2014-01-01

    Esta tesis propone un estudio comparado de la poética del silencio desde el siglo XII al XX en una serie de obras en las que se relacionan imagen y texto, ordenadas en tres series: gestos, mapas y colores. La primera considera la representación de la inefabilidad del lenguaje divino en Hildegard von Bingen, y las variaciones del gesto harpocrático en la emblemática barroca. La segunda reúne las descripciones excesivas de Georges Perec y Jorge Luis Borges con los saturados mapas portulanos del...

  12. Do PT and APTT sensitivities to factors' deficiencies calculated by the H47-A2 2008 CLSI guideline reflect the deficiencies found in plasmas from patients?

    Science.gov (United States)

    Martinuzzo, M; Barrera, L; Rodriguez, M; D'Adamo, M A; López, M S; Otaso, J C

    2015-12-01

    Prothrombin time (PT) and activated partial thromboplastin time (APTT) sensitivity for detecting isolated factor deficiencies varies with different reagents and coagulometers. The Clinical and Laboratory Standards Institute (CLSI) H47A2 guideline proposed a method to calculate these sensitivities, but some inconsistency has been reported. This study aimed to calculate factor sensitivities using CLSI guideline and to compare them with those obtained from single factor-deficient patients' data. Different mixtures of normal pooled and deficient plasmas were prepared (CLSI H47A2 guideline. PT with rabbit brain (RB) and human recombinant (HR) thromboplastins, APTT and factors' activities were measured in an ACL TOP coagulometer. Sensitivities (maximum factor concentration that produces PT or APTT values out of the reference range) were calculated from mixtures and from patients with single-factor deficiencies: 17 factor FV, 36 FVII, 19 FX, 39 FVIII, 15 FIX 15 FXI and 24 FXII. PT sensitivity with RB was as follows: FV 38 and 59, FVII 35 and 58, FX 56 and 64 IU/dL; PT sensitivity with HR was as follows: FV 39 and 45, FVII 51 and 50, FX 33 and 61 IU/dL; and APTT sensitivity was as follows: FV 39 and 45, FX 32 and 38, FVIII 47 and 60, FIX 35 and 44, FXI 33 and 43, FXII 37 and 46 IU/dL, respectively. Reagent-coagulometer combination has adequate sensitivities to factor deficiencies according to guideline recommendations (>30 IU/dL). These should not be considered as actual sensitivities because those obtained by analysing patients' plasmas with single-factor deficiencies were higher for most factors and could induce misinterpretation of the basic coagulation test results. © 2015 John Wiley & Sons Ltd.

  13. Soft X-ray emissions of highly charged Si VII--Si XII in cool star--Procyon

    CERN Document Server

    Liang, G Y

    2007-01-01

    Different observation data for cool star--Procyon (Obs\\_IDs of 63, 1461 and 1224) available from {\\it Chandra Data Public Archive} were co-added and analyzed. Emissivities of emission lines of highly charged silicon ions (Si VII--Si XII) were calculated over temperatures by adopting the published data of Liang et al. (2007, {\\it Atom. Data and Nucl. Data Tables}, {\\bf 93}, 375). Using the emission measure derived by Raassen et al. (2002, A&A, {\\bf 389}, 228), the theoretical line fluxes are predicted, and the theoretical spectra are constructed by assuming the Gaussian profile with instrumental broadening (0.06 \\AA). By detailed comparison between observation and predictions, several emissions lines are identified firstly such as emissions at 43.663 \\AA (Si XI), 45.550 \\AA (Si XII), 46.179 \\AA (Si VIII), 50.874 \\AA (Si X), 64.668 \\AA (Si IX), and 73.189 \\AA (Si VII) etc. Several emission lines are re-assigned in this work, such as the emission line at 52.594 \\AA to Si X (52.612 \\AA), at 69.641 \\AA to the ...

  14. Anti-Inflammatory Effects of IKK Inhibitor XII, Thymulin, and Fat-Soluble Antioxidants in LPS-Treated Mice

    Science.gov (United States)

    Novoselova, E. G.; Khrenov, M. O.; Glushkova, O. V.; Lunin, S. M.; Parfenyuk, S. B.; Novoselova, T. V.; Fesenko, E. E.

    2014-01-01

    The present study was designed to compare the anti-inflammatory effects of several agents applied in vivo, namely, a synthetic inhibitor of the NF-κB cascade, fat-soluble antioxidants, and the thymic peptide thymulin. Cytokine response in LPS-treated mice was analysed in tandem with the following parameters: the synthesis of inducible forms of the heat shock proteins HSP72 and HSP90α; activity of the NF-κB and SAPK/JNK signalling pathways; and TLR4 expression. Inflammation-bearing Balb/c male mice were pretreated with an inhibitor of IKK-α/β kinases (IKK Inhibitor XII); with thymulin; with dietary coenzyme Q9, α-tocopherol, and β-carotene; or with combinations of the inhibitor and peptide or antioxidants. Comparable anti-inflammatory effects were observed in inflammation-bearing mice treated separately with thymulin or with dietary antioxidants administered daily for two weeks before LPS treatment. When LPS-injected mice were treated with the inhibitor and antioxidants together, neither plasma cytokines, signal proteins, nor heat shock proteins recovered more efficiently than when mice were treated with these agents separately. In contrast to antioxidant diet, the thymulin was shown to increase the effect of IKK Inhibitor XII in preventing IKK activation in LPS-treated mice. PMID:25045213

  15. Bayesian estimation of finite3-component mixture of Burr Type-XII distributions assuming Type-I right censoring scheme

    Directory of Open Access Journals (Sweden)

    M. Tahir

    2016-12-01

    Full Text Available As compared to simple models, the mixture models of underlying lifetime distributions are intuitively more appropriate and appealing to model the heterogeneous nature of process. This study focuses on the problem of estimating the parameters of a newly developed 3-component mixture of Burr Type-XII distributions using Type-I right censored data. Firstly, considering a Bayesian structure, some mathematical properties of a 3-component mixture of Burr Type-XII distributions are discussed. These mathematical properties include Bayes estimators and posterior risks for the unknown component and proportion parameters using the non-informative and the informative priors under squared error loss function, precautionary loss function and DeGroot loss function. Secondly, in case when no or little prior information is available, elicitation of hyperparameters is given. Also, the posterior predictive distribution for a future observation and the Bayesian predictive interval are constructed. Moreover, the limiting expressions for the Bayes estimators and posterior risks are derived. In addition, the performance of the Bayes estimators for different sample sizes, test termination times and parametric values under different loss functions is investigated. Finally, simulated datasets are designed for the different comparisons and the model is illustrated using the real data.

  16. Calatrava. Una villa en la frontera castellano-andalusí del siglo XII

    Directory of Open Access Journals (Sweden)

    Rodríguez-Picavea Matilla, Enrique

    2000-12-01

    Full Text Available The aim of this article is to analyze the complex reality of frontier towns through a significant example: the town of Calatrava in the 12th century. The study starts with the incorporation of Calatrava and its area into te kingdom of Alfonso VII of Castile-Leon. After that, there began a difficult period that passed through four significant phases: the first decade of Christian control; the establishment of Calatrava dominion; the period of Almohad control; and, finally, the Christian recovery, that involved the extended decay of the named town. This is the end of the paper. Beside the special circumstances in which the frontier town of Calatrava was entangled, the article deals also with the economical activities, the fuero that Alfonso VII granted to the town, the organization of its council and the peculiar ecclesiastical organization, as a result of the presence there of the Military Order of Calatrava. The article ends with the edition of two documents of the 12th century, that are kept in the Section of "Órdenes Militares" of the Archivo Histórico Nacional (Madrid.[fr] Ce travail veut analyser la complexe réalité des villes frontières de la Péninsule à travers un exemple significatif, celui de la ville de Calatrava au XII siècle. Le point de départ de l'étude se place au moment de l'intégration de la ville de Calatrava et de son vaste finage dans le royaume castellano-léonais d'Alphonse VII Alors commence une évolution complexe qui passe par quatre phases successives: la première décennie de la domination chrétienne, l'implantation de la seigneurie de Calatrava, l'étape de domination almohade et la récupération chrétienne signifiant le début du déclin prolongé de l'agglomération qui marque le point final du travail. Outre les circonstances de l'évolution frontalière de Calatrava, sont ici étudiées les activités économiques, le charte de peuplement concédée à la ville par Alphonse VII, son

  17. Theoretical studies of the atomic transitions in boron-like ions: Mg VIII, Si X and S XII

    Energy Technology Data Exchange (ETDEWEB)

    Nataraj, H S [Non-Accelerator Particle Physics Group, Indian Institute of Astrophysics, Bangalore-34 (India); Sahoo, B K [Max Planck Institute for the Physics of Complex Systems, Noethnitzer Street 38, D-01187 Dresden (Germany); Das, B P [Non-Accelerator Particle Physics Group, Indian Institute of Astrophysics, Bangalore-34 (India); Chaudhuri, R K [Non-Accelerator Particle Physics Group, Indian Institute of Astrophysics, Bangalore-34 (India); Mukherjee, D [Department of Physical Chemistry, Indian Association for Cultivation of Science, Kolkata-700 032 (India)

    2007-08-14

    In this paper, we have carried out the calculations of the weighted oscillator strengths and the transition probabilities for a few low-lying transitions of boron-like ions: Mg VIII, Si X and S XII, which are astrophysically important, particularly in the atmosphere of the solar corona. We have employed an all-order relativistic many-body theory called the relativistic coupled-cluster theory to calculate very precisely these atomic quantities of astrophysical interest. We have reported for the first time the transition probabilities for some forbidden transitions which are unavailable in the literature, either theoretically or experimentally. We also discuss the physical effects associated with these transitions. Our data can be used for the identification of spectral lines arising from the coronal atmospheres of the Sun and Sun-like stars having an extended corona.

  18. Voyages of a successful text. The Dialogi of Gregory the Great in Medieval Sicily (XII-XIV Century

    Directory of Open Access Journals (Sweden)

    Rossana Barcellona

    2013-10-01

    Full Text Available This essay reconstructs two “Sicilian chapters” of great success from the Dialogi by Gregorius Magnus which were enjoyed in the medieval era. These are the legend of Placido (Placido is a Benedict's young disciple mentioned in the Dialogi, which has Sicily as a background, as recounted by Pietro, Deacon of Montecassino between the XI and the XII centuries, and the Sicilian vulgarization of the work, carried out by Giovanni Campolo in the first half of the XIV century. The literary voyage of Placido and the work of Campolo are two excellent examples of the circulation and the fruition of an exemplary and authoritative text. Each highlights the complex intricacy of religion, culture and politics in the various systems of power and in the various historical settings that the medieval age explored.

  19. La función de la pena por la "iniuria" en la Ley de las XII Tablas

    OpenAIRE

    Carvajal,Patricio-Ignacio

    2013-01-01

    En el Derecho arcaico de la Ley de las XII Tablas no existió una noción general de la iniuria y debe evitarse la anticipación del concepto clásico a entonce. Por lo demás, que las conductas hubieran sido sancionadas con una escala de penas que correspondía a su mayor o menor gravedad es una ilusión. Las únicas conductas sancionadas fueron la membri ruptio (VIII,2) y la ossis fractio (VIII,3), y en ambos casos se aplicó el talión. La Tab. VIII, 4 no parece referirse a una conducta autónoma, si...

  20. Influencia de la historia de España (del siglo XII al XIX en el periodismo especializado en ciencia

    Directory of Open Access Journals (Sweden)

    Dr. Carlos Elías

    2001-01-01

    Full Text Available El periodismo especializado en ciencia y tecnología en España no ha alcanzado los niveles de los países anglosajones. Ello se pone de manifiesto no sólo por la relativa ausencia de suplementos destinados a ciencia en los periódicos generalistas sino, sobre todo, por la ausencia de portales de Internet en los que se divulgue la ciencia en español así como los logros en este campo de la comunidad hispana. Pero esta circunstancia no es casual: es el producto de una historia, la de la ciencia en España, que siempre ha tenido muchos detractores, entre ellos la iglesia. En este artículo se analiza cómo influyó la historia de España desde el siglo XII hasta principios del XIX en el actual periodismo especializado en ciencia.

  1. PENGARUH INTERNAL LOCUS OF CONTROL DAN SELF-EFFICACY TERHADAP CAREER MATURITY SISWA KELAS XII SMK DI KABUPATEN KUDUS

    Directory of Open Access Journals (Sweden)

    Novita Larasati

    2016-11-01

    Full Text Available Berdasarkan studi pendahuluan diketahui bahwa 92,4% siswa kelas XII SMK di Kabupaten Kudus masih ragu-ragu dalam membuat keputusan karir. Hal ini mengindikasikan bahwa career maturity siswa masih rendah. Penelitian ini bertujuan untuk mengetahui pengaruh internal locus of control dan self-efficacy terhadap career maturity. Populasi penelitian ini adalah siswa kelas XII SMK di Kabupaten Kudus yang berjumla 4230 siswa dan teknik pengambilan sampel yang digunakan adalah multi-stage sampling, sehingga jumlah sampelnya adalah 70 siswa. Metode pengumpulan data menggunakan angket. Metode analisis data menggunakan analisis deskriptif presentase dan analisis regresi berganda. Analisis deskriptif diperoleh bahwa career maturity dalam kategori mature, internal locus of control dalam kondisi baik, dan self-efficacy dalam kondisi baik. Hasil penelitian menunjukkan bahwa terdapat pengaruh internal locus of control terhadap career maturity sebesar 50,55%, pengaruh self-efficacy terhadap career maturity sebesar 9,8%, dan pengaruh internal locus of control dan self-efficacy terhadap caeer maturity sebesar 81,3%. Simpulan dari penelitian ini adalahinternal locus of control dan self-efficacy berpengaruh terhadap career maturity baik secara parsial maupun simultan.Saran yang diberikan bagi pihak sekolah maupun siswa hendaknya lebih meningkatkan career maturity yang dimiliki dengan lebih banyak mencari informasi yang relevan untuk meningkatkan kesiapan siswa dalam membuat keputusan-keputusan karir yang tepat. Based on the preliminary study known that as many as 92.4% of students in XII grade of SMK in Kudus was hesitant to making decisions vocational career. It is indicated that the students have a low career maturity. This study aimed to determine the effect of an internal locus of control and self-efficacy towards career maturity. The population was all of XII grade vocational school students in Kudus regency totaling 4320 students and the sampling technique used

  2. Notas sobre la penetración del derecho común en Galicia (siglos XII-XV

    Directory of Open Access Journals (Sweden)

    Martínez Martínez, Faustino

    2001-12-01

    Full Text Available This work on the galician case places in a general thinking about the fenomena, comon to other territories of Iberian Peninsula, of the so-called Common Law reception. Our area was not an exception to this process fully developed from XII and XIII centuries. Across this paper we study the conditions that improve the arrival of this new legal conception (the so-called penetration. The penetration will lay the foundation for the later reception. We study the progressive assimilation of the common law looking into different documents that shows the legal practice (wills, contracts, sentences....

    El presente trabajo se enmarca dentro de una reflexión general sobre el fenómeno, común a otros territorios de la Península Ibérica, de la llamada recepción del Derecho Común, centrado por razones obvias en Galicia. Nuestra región no fue una excepción a este proceso que se desarrolla con plenitud a partir de los siglos XII y XIII. A través de las páginas de esta colaboración se estudian las condiciones que favorecieron la llegada de las primeras manifestaciones de esta nueva concepción del Derecho (la llamada propiamente «penetración» que sentará las bases para una posterior «recepción». Estudiamos la progresiva asimilación del derecho común mediante el examen de diferentes documentos que muestran la práctica jurídica (testamentos, contratos, sentencias, etc..

  3. Coagulation factor deficiency apparently related to the Fitzgerald trait: the first cases in Japan.

    Directory of Open Access Journals (Sweden)

    Hayashi,Hisamoto

    1978-04-01

    Full Text Available A blood coagulation deficiency was found at the contact phase in identical Japanese female twins. Of the four possible factors involved, Factor XI or XII can be ruled out according to cross-correction studies. The problem factor was probably not Fletcher factor, because the abnormal partial thromboplastin time was not significantly shortened by increasing the incubation period of plasma with kaolin. The deficiency is most likely due to the lack of Fitzgerald factor.

  4. PREFACE: XII Latin American workshop on plasma physics (17-21 September 2007, Caracas, Venezuela)

    Science.gov (United States)

    Puerta, Julio

    2008-10-01

    Some years ago a group of Latin American physicists took the initiative to consult about the viability of organizing a meeting on plasma physics for researchers and students of the region. The result was that it was not only a good idea, but a necessity in order to show and share everyone's work, and to keep updated on latest advances and technologies on plasma physics. It was decided that for new researchers as well as students of Physics, it would prove to be the best way to keep them posted on such matters. This was the birth of a series of meetings known as Latin American workshops on plasma physics that take place every two years in a different Latin American country. In Venezuela we have had the opportunity to organize two editions of this interesting and important reunion of physicists. The first of these Latin American workshops on plasma physics was held in Cambuquira (Brazil) in 1982. After organizing the first six editions of the workshop, the VII LAWPP meeting was realized in Caracas in January 1997. It was designed with a structure similar to the first edition. It developed in two stages, a first week devoted to short courses with lecturers in different fields of plasma physics and a second week for contributed and invited presentations. Participants from sixteen different countries were present, half of them from this continent and the other half from overseas, demonstrating the international character of this meeting. There have been four more editions of the workshop and once again, we have had the opportunity to organize this latest edition of the series: the XII Latin American workshop on plasma physics, which took place in Caracas, Venezuela from the 17th to the 21st of September 2007. The structure was modified, because contributed and review papers were together during the first stage, with short courses realized during the second one, called mini-courses, and given by several high level contributors such as José Boedo, Leopoldo Soto, Claude

  5. El castillo de Portilla (Zambrana, Álava: Origen y significado de una fortaleza plenomedieval en territorio alavés (siglos XI-XII

    Directory of Open Access Journals (Sweden)

    Jose Luis Solaun Bustinza, Agustín Azkarate Garai-Olaun

    2016-01-01

    Las recientes investigaciones arqueológicas efectuadas en esta fortaleza han permitido conocer mejor su origen y significado. Las evidencias apuntan a que la actual fortaleza, construida entre principios del siglo XI y mediados del siglo XII, estuvo bajo titularidad real, aunque fue gestionada por importantes aristocracias locales y regionales, siendo testigo de las complejas relaciones entre el poder público y privado y, obviamente, de la multiplicidad de funciones que esta fortaleza pudo desempeñar.

  6. Mono- and di-halogenated histamine, histidine and carnosine derivatives are potent carbonic anhydrase I, II, VII, XII and XIV activators.

    Science.gov (United States)

    Saada, Mohamed-Chiheb; Vullo, Daniela; Montero, Jean-Louis; Scozzafava, Andrea; Supuran, Claudiu T; Winum, Jean-Yves

    2014-09-01

    Mono- and di-halogenated histamines, l-histidine methyl ester derivatives and carnosine derivatives incorporating chlorine, bromine and iodine were prepared and investigated as activators of five carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic hCA I, II and VII, and the transmembrane hCA XII and XIV. All of them were activated in a diverse manner by the investigated compounds, with a distinct activation profile.

  7. 77 FR 29633 - Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC...

    Science.gov (United States)

    2012-05-18

    ... [Federal Register Volume 77, Number 97 (Friday, May 18, 2012)] [Notices] [Page 29633] [FR Doc No: 2012-12075] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL12-68-000] Alta Wind VII, LLC, Alta Wind IX, LLC, Alta Wind X, LLC, Alta Wind XI, LLC, Alta Wind XII, LLC, Alta Wind XIII, LLC, Alta Wind XIV, LLC, Alta Wind XV, LLC...

  8. Penerapan Metode Kontekstual Untuk Meningkatkan Kemampuan Menulis Cerita Pendek Siswa Kelas XII IPS-3 SMA Negeri 3 Bojonegoro Tahun Pelajaran 2011/2012.

    Directory of Open Access Journals (Sweden)

    . Susanto

    2014-07-01

    Full Text Available Abstract: Implementation of Contextual Method for Improving Writing Skill of Short Story Class-XII IPS 3 SMA Bojonegoro Academic Year 2011/2012. Writing short stories for high school students is considered a difficult activity. Trouble to write his ideas properly. It is also experienced by students of SMA Negeri 3 Bojonegoroclass-XII IPS 3. In this study using contextual learning methods, namely the method of selecting information based on the needs of individual students. The results show contextual application of the method can improve the quality of student learning outcomes writing short stories class XII IPS 3 SMAN 3 Bojonegoro school year 2011/2012. This isindicated by the increase in the percentage of students who achieve a range of 85-100. For comparison the results of short stories written in the early reflections only 11.42%, i.e. 11.42%  first cycle, whereas 28.57% in the second cycle. So also in the range of 0-44 also decreased. For comparison, the pre-action is 20.01%, 14.30% first cycle, second cycleand 14.30%. Key words: Contextual Method, Learning Writing, Short Story.

  9. The Correlation of Students Knowledge Level About Menstrual with Dysmenorrhea Handling Effort on Classes XII Students At SMA Negeri 1 Parongpong

    Directory of Open Access Journals (Sweden)

    Drs. Oktoruddin Harun

    2015-08-01

    Full Text Available Background reproductive health is a problem that most important to get attention especially among teenagers an effort to get to the healthy have to start at least in the early adolescence because teenagers to be prepared either knowledge attitude or the act of which reached at reproduction healthy. An incident the occurrence of the average dysmenorrhea in young women between 168 81. Some of them are yet resulted in heavy dysmenorrhea so as to interrupt activities such as not going to school. The purpose of this research is to knowledge of menstruation relations with dysmenorrhea handling effort on classes XII students at SMA Negeri 1 Parongpong. The method is applicable study analitik with a method of approach cross-sectional. The total sample 62 students classes XII with been gained through total sampling data collection techniques directly from respondents with the methods in the form of a questionnaire. The results of this research is 62 student on classes XII at SMA Negeri 1 Parongpong having a lack of knowledge of the menses that is some 20 323 students and the level of knowledge have enough that is some 25 403 students while the level of knowledge have good that is some 17 274 students. In efforts to handle dysmenorrhea so that the level of handling pain diminished that is some 33 532 students and with the level of handling so that pain increase that is some 29 468 students.

  10. PENINGKATAN KREATIVITAS BERWIRAUSAHA SISWA KELAS XII JASA BOGA 1 DALAM PENGOLAHAN LIMBAH BANDENG SEBAGAI PELUANG USAHA MELALUI UNIT PRODUKSI DI SMK NEGERI 3 PATI

    Directory of Open Access Journals (Sweden)

    Sri Puji Haryati

    2015-08-01

    Full Text Available The research aims are to: 1 increase students' creativity entrepreneurship Catering 1 Class XII in treating waste as a business opportunity thorns milkfish through the utilization of Production Unit of SMK Negeri 3 Pati and 2 determine the magnitude of the increase in Class XII student entrepreneurship creativity Catering 1 after using Production Unit of SMK Negeri 3 Pati. The method used is descriptive, the technique of classroom action research through qualitative and quantitative analysis. The pprinciples of recycling activity/procedures are: planning, acting, observing, and reflecting. Research held at SMK Negeri 3 Pati, with as many as 31 research subjects. Techniques of data collection are: observation, interviews, field notes, documentation. This study uses an interactive analysis that consists of data collection, data reduction, data presentation and conclusion. The research results showed that there is an increase in entrepreneurial creativity of each cycle, as seen in the first cycle the average value of creativity in entrepreneurship is 81% (the category of "creative" once held the second cycle to 94% (the category of "very creative", so that there is an increase in by 13%. In conclusion empowerment Production Unit Schools can improve the creativity of class XII student entrepreneurship Catering 1 in creating business opportunities through waste treatment milkfish.

  11. Gesta Roderici: El Cid en la historiografía latina medieval del siglo XII

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    Francisco Javier PEÑA PÉREZ

    2010-12-01

    Full Text Available La memoria histórica de Rodrigo Díaz estuvo a punto de perderse tras la pérdida de Valencia a manos de los almorávides y el declive posterior del imperio levantado por éstos. Pero la llegada a la Península Ibérica de los almohades y su agresividad progresiva contra los cristianos del norte hispano desde medidos del siglo xii reavivó los recuerdos del pasado almorávide y de su verdugo más exitoso: el Cid Campeador, creando con ello las condiciones para que la memoria cidiana resurgiera de sus cenizas con renovado brío, aunque sensiblemente estilizada. Dadas las condiciones, los cronistas se ponen manos a la obra, allí donde los recuerdos del caballero castellano pudieron guardarse con más esmero: la corte Navarra, a finales del xii, y el monasterio de Cardeña, en el siglo siguiente.La mémoire historique de Rodrigo Díaz fut sur le point de se perdre en raison de la conquête de Valence par les Almoravides puis du déclin de l'empire érigé par ces derniers. Mais l'arrivée dans la péninsule ibérique des Almohades, ainsi que leur progressive agressivité envers les chrétiens du nord hispanique à partir du XIIè siècle, raviva les souvenirs du passé almoravide et de son plus célèbre ennemi, le Cid Campeador, créant ainsi les conditions nécessaires pour que renaisse de ses cendres la mémoire populaire relative au Cid, et ce avec une vigueur nouvelle, bien que considérablement stylisée. Étant donné ces conditions, les chroniqueurs se sont mis au travail, là où les souvenirs du chevalier castillan avaient pu être conservés avec le plus de soin : la cour de Navarre, à la fin du XIIe siècle, et le monastère de Cardeña, au siècle suivant.

  12. PENGARUH PRAKTIK KERJA INDUSTRI DAN LINGKUNGAN KELUARGA TERHADAP MOTIVASI BERWIRAUSAHA SISWA KELAS XII PEMASARAN SMK NEGERI 2 SEMARANG

    Directory of Open Access Journals (Sweden)

    Sodikin

    2014-06-01

    Full Text Available Motivasi siswa untuk menjadi seorang wirausaha dipengaruhi oleh praktik kerja industri dan lingkungan keluarga. Permasalahan penelitian ini adalah: sebesar besar pengaruh praktik kerja industri dan lingkungan keluarga terhadap motivasi berwirausaha siswa baik secara parsial maupun simultan. Populasi dalam penelitian ini berjumlah 99 siswa yang terdiri dari kelas XII Pemasaran SMK Negeri 2 Semarang, karena merupakan penelitian populasi sehingga semua populasi dijadikan sampel penelitian. Variabel yang diteliti yaitu variabel praktik kerja industri, lingkungan keluarga dan motivasi berwirausaha. Metode pengumpulan data menggunakan angket dan dokumentasi. Analisis data menggunakan analisis deskripsi persentase dan analisis regresi berganda. Hasil penelitian uji regresi menunjukkan hasil uji parsial untuk praktik kerja industri diperoleh thitung sebesar 4,847 dengan signifikansi 0,000 dan lingkungan keluarga diperoleh thitung sebesar 3,182 dengan signifikansi 0,002 berarti H0 ditolak dan Ha1, Ha2, Ha3 diterima. Besarnya pengaruh secara parsial untuk variabel praktik kerja industri sebesar 19,62% dan lingkungan keluarga sebesar 9,55%, secara simultan sebesar 44%. Student motivation to become an entrepreneur is influenced by industry work practices and family environment. The problems of this research are: the influence of industry work practices and family environment against entrepreneurial motivation either partially or simultaneously. The population in this study is composed of 99 students of class XII SMK N 2 Semarang Marketing, as a research population so that all the population made research sample. The variables studied were industry work practices, family environment and entrepreneurial motivation. Methods of data collection using questionnaire and documentation. Data analysis using descriptive analysis and multiple regression analysis percentage. Results of regression studies showed partial test results obtained for industrial work practices

  13. Lista comentada e ilustrada dos Caecidae (Mollusca, Prosobranchia, Mesogastropoda da Operação Oceanográfica Geomar XII Commented and illustrated list of the Caecidae (Mollusca, Prosobranchia, Mesogastropoda from Oceanographic Operation Geomar XII

    Directory of Open Access Journals (Sweden)

    Renata dos Santos Gomes

    1996-01-01

    Full Text Available The family Caecidae deserved special attention, among mollusks, because they occurred in more than 50% of studied stations in Oceanographic Operation Geomar XII, which was carried out in northern and southern coasts of Rio de Janeiro and Espírito Santo States (Brazil, respectively. At the time, Caecum brasilicum Folin, 1874, C. aff condylum Moore, 1969, C. circumvolutum Folin, 1867, C. johnsoni Winkley, 1908, C. someri Folin, 1867, C. striatum Folin, 1868, C. venosum Folin, 1867, C. floridanum Stimpson, 1851, C. massambabensis Absalão, 1994, C. butoti Jong & Coomans, 1989, C. ryssotitum Folin, 1867, C. nitidum (Stimpson., 1851 e C. cubitatum (Folin, 1868 were identitíed. C. venosum is reported, for the first time, since its original description, enlarging its occurrence area from Pernambuco to Rio de Janeiro; C. buloti as well, primarily restricted to Dutch Antilles, begins to make part of the Brazilian malacofauna. C. someri and C. butoti were pointed out for being largely non-sintopic with other congeneric species, suggesting that subtile differences in sediment can be responsable for this segregation.

  14. Calculations with spectroscopic accuracy: energies and transition rates in the nitrogen isoelectronic sequence from Ar XII to Zn XXIV

    CERN Document Server

    Wang, K; Dang, W; Jönsson, P; Guo, X L; Li, S; Chen, Z B; Zhang, H; Long, F Y; Liu, H T; Li, D F; Hutton, R; Chen, C Y; Yan, J

    2016-01-01

    Combined relativistic configuration interaction and many-body perturbation calculations are performed for the 359 fine-structure levels of the $2s^2 2p^3$, $2s 2p^4$, $2p^5$, $2s^2 2p^2 3l$, $2s 2p^3 3l$, $2p^4 3l$, and $2s^2 2p^2 4l$ configurations in N-like ions from Ar XII to Zn XXIV. A complete and consistent data set of energies, wavelengths, radiative rates, oscillator strengths, and line strengths for all possible electric dipole, magnetic dipole, electric quadrupole, and magnetic quadrupole transitions among the 359 levels are given for each ion. The present work significantly increases the amount of accurate data for ions in the nitrogen-like sequence, and the accuracy of the energy levels is high enough to serve identification and interpretation of observed spectra involving the $n=3,4$ levels, for which the experimental values are largely scarce. Meanwhile, the results should be of great help in modeling and diagnosing astrophysical and fusion plasmas.

  15. Dirac R-matrix calculations of photoionization cross sections of Ni XII and atomic structure data of Ni XIII

    Science.gov (United States)

    Nazir, R. T.; Bari, M. A.; Bilal, M.; Sardar, S.; Nasim, M. H.; Salahuddin, M.

    2017-02-01

    We performed R-matrix calculations for photoionization cross sections of the two ground state configuration 3s23p5 (^2P^o3/2,1/2) levels and 12 excited states of Ni XII using relativistic Dirac Atomic R-matrix Codes (DARC) across the photon energy range between the ionizations thresholds of the corresponding states and well above the thresholds of the last level of the Ni XIII target ion. Generally, a good agreement is obtained between our results and the earlier theoretical photoionization cross sections. Moreover, we have used two independent fully relativistic GRASP and FAC codes to calculate fine-structure energy levels, wavelengths, oscillator strengths, transitions rates among the lowest 48 levels belonging to the configuration (3s23p4, 3s3p5, 3p6, 3s23p33d) in Ni XIII. Additionally, radiative lifetimes of all the excited states of Ni XIII are presented. Our results of the atomic structure of Ni XIII show good agreement with other theoretical and experimental results available in the literature. A good agreement is found between our calculated lifetimes and the experimental ones. Our present results are useful for plasma diagnostic of fusion and astrophysical plasmas.

  16. Frontera y órdenes militares en la Edad Media castellano-leonesa (siglos XII-XIII

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    Carlos de AYALA MARTÍNEZ

    2009-12-01

    Full Text Available RESUMEN: El estudio presenta una breve panorámica del papel de las órdenes militares castellano-leonesas en la formación y consolidación de la frontera del reino con el Islam en los siglos XII y XIII. Ese papel tiene una triple dimensión –militar, colonizadora y estrictamente política– y sólo es posible constatar su eficacia a raíz del afianzamiento territorial e institucional de las órdenes militares, es decir, a partir del primer tercio del siglo XIII.ABSTRACT: The survey presents a brief view of the Castillian-Leonese military order’s role in the formation and consolidation of the kingdom’s border with the Islam in the twelfth and thirteenth centuries. This role has a triple dimension –military, settler and strictly political– and it is only possible to show its efficiency from the territorial and institutional strengthening of the military orders, that is, from the first third of the thirteenth century.

  17. Mapping of extreme resistance to PVY (Ry (sto)) on chromosome XII using anther-culture-derived primary dihaploid potato lines.

    Science.gov (United States)

    Song, Ye-Su; Hepting, Leonard; Schweizer, Günther; Hartl, Lorenz; Wenzel, Gerhard; Schwarzfischer, Andrea

    2005-09-01

    The inheritance of extreme resistance to PVY (Ry (sto)) by a single dominant locus was confirmed by obtaining a 1:1 segregation ratio in a virus inoculation test with 28 resistant (Ryry) to 29 susceptible (ryry) anther culture-derived dihaploid lines (2n=2x=24) from cv. "Assia" (2n=4x=48) having extreme resistance derived from Solanum stoloniferum in simplex constitution (Ryryryry). Twelve Ry (sto) markers selected in AFLP assays using bulked segregant analysis were applied to 106 tested potato cultivars from Germany, The Netherlands and Poland and 19 potato cultivars were identified by these markers as extremely resistant to PVY in alignment with phenotypic data. The locus for extreme resistance (Ry (sto)) to PVY was mapped on chromosome XII co-segregating with the SSR marker STM 0003. The utility of anther-culture derived dihaploid potatoes for genetic marker development was demonstrated. Marker transferability from diploids to tetraploids provides an optimistic potential for marker-assisted selection in potato breeding programs.

  18. Investigation of Hot X-ray Points (HXPs) Using Spectroheliograph Mg XII Experiment Data From CORONAS-F/SPIRIT

    CERN Document Server

    Reva, Anton; Bogachev, Sergey; Kuzin, Sergey

    2015-01-01

    Observations in the Mg XII 8.42 AA line onboard the CORONAS-F satellite have revealed compact high temperature objects-hot X-ray points (HXP)-and their major physical parameters were investigated. Time dependencies of temperature, emission measure, intensity, and electron density were measured for 169 HXPs. HXP can be divided into two groups by their temperature variations: those with gradually decreasing temperature and those with rapidly decreasing temperature. HXPs plasma temperatures lie in the range of 5-40 MK, the emission measure is $10^{45}$- $10^{48}$ cm$^{-3}$, and the electron density is above $10^{10}$ cm$^{-3}$, which exceeds the electron density in the quiet Sun ($10^8$-$10^9$ cm$^{-3}$). HXPs lifetimes vary between 5-100 minutes, significantly longer than the conductive cooling time. This means that throughout a HXP's lifetime, the energy release process continues, which helps to maintain its high temperature. A HXP's thermal energy is not greater than $10^{28}$ erg, and the total energy, which...

  19. MOJAVE. XII. ACCELERATION AND COLLIMATION OF BLAZAR JETS ON PARSEC SCALES

    Energy Technology Data Exchange (ETDEWEB)

    Homan, D. C. [Department of Physics, Denison University, Granville, OH 43023 (United States); Lister, M. L.; Richards, J. L. [Department of Physics, Purdue University, 525 Northwestern Avenue, West Lafayette, IN 47907 (United States); Kovalev, Y. Y. [Astro Space Center of Lebedev Physical Institute, Profsoyuznaya 84/32, 117997 Moscow (Russian Federation); Pushkarev, A. B.; Savolainen, T.; Ros, E. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Kellermann, K. I., E-mail: homand@denison.edu [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States)

    2015-01-10

    We report on the acceleration properties of 329 features in 95 blazar jets from the MOJAVE Very Long Baseline Array program. Nearly half the features and three-quarters of the jets show significant changes in speed and/or direction. In general, apparent speed changes are distinctly larger than changes in direction, indicating that changes in the Lorentz factors of jet features dominate the observed speed changes rather than bends along the line of sight. Observed accelerations tend to increase the speed of features near the jet base, ≲ 10-20 pc projected, and decrease their speed at longer distances. The range of apparent speeds at a fixed distance in an individual jet can span a factor of a few, indicating that shock properties and geometry may influence the apparent motions; however, we suggest that the broad trend of jet features increasing their speed near the origin is due to an overall acceleration of the jet flow out to deprojected distances of the order of 10{sup 2} pc, beyond which the flow begins to decelerate or remains nearly constant in speed. We estimate intrinsic rates of change of the Lorentz factors in the galaxy frame of the order of Γ-dot /Γ≃10{sup −3} to 10{sup –2} yr{sup –1}, which can lead to total Lorentz factor changes of a factor of a few on the length scales observed here. Finally, we also find evidence for jet collimation at projected distances of ≲ 10 pc in the form of the non-radial motion and bending accelerations that tend to better align features with the inner jet.

  20. Quantitative analysis of substituted N,N-dimethyl-tryptamines in the presence of natural type XII alkaloids.

    Science.gov (United States)

    Ivanova, Bojidarka; Spiteller, Michael

    2012-10-01

    This paper reports the qualitative and quantitative analysis (QA) of mixtures of hallucinogens, N,N-dimethyltryptamine (DMT) (1), 5-methoxy- (la) and 5-hydroxy-N,N-dimethyltryptamine (1b) in the presence of beta-carbolines (indole alkaloids of type XII) ((2), (3) and (5)}. The validated electronic absorption spectroscopic (EAs) protocol achieved a concentration limit of detection (LOD) of 7.2.10(-7) mol/L {concentration limit of quantification (LOQ) of 24.10(-7) mol/L) using bands (lambda max within 260+/-0.23-262+/-0.33 nm. Metrology, including accuracy, measurement repeatability, measurement precision, trueness of measurement, and reproducibility of the measurements are presented using N,N-dimethyltryptamine (DMA) as standard. The analytical quantities of mixtures of alkaloids 4, 6 and 7 are: lambda max 317+/-0.45, 338+/-0.69 and 430+/-0.09 for 4 (LOD, 8.6.10(-7) mol/L; LOQ, 28.66(6), mol/L), as well as 528+/-0.75 nm for 6 and 7 (LOD, 8.2.10(-7) mol/L; LOQ, 27.33(3), mol/L), respectively. The partially validated protocols by high performance liquid chromatography (HPLC), electrospray ionization (ESI), mass spectrometry (MS), both in single and tandem operation (MS/MS) mode, as well as matrix/assisted laser desorption/ionization (MALDI) MS are elaborated. The Raman spectroscopic (RS) protocol for analysis of psychoactive substances, characterized by strong fluorescence RS profile was developed, with the detection limits being discussed. The known synergistic effect leading to increase the psychoactive and hallucinogenic properties and the reported acute poisoning cases from 1-7, make the present study emergent, since as well the current lack of analytical data and the herein metrology obtained contributed to the elaboration of highly selective and precise analytical protocols, which would be of interest in the field of criminal forensic analysis.

  1. Esclavos musulmanes en los hospitales de cautivos de la Orden Militar de Santiago (siglos XII y XIII

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    Echevarría Arsuaga, Ana

    2007-12-01

    Full Text Available Military Orders had slave manpower in their lands since their foundation. However, the hospitals for ransoming captives owned by the Order of Santiago are the best example of how slavery worked in the kingdom of Leon-Castile during the twelfth and thirteenth centuries. These houses had enough room to provide lodging for captives while ransoms were being negotiated. They also helped to redistribute those Muslims who, lacking this possibility, became slaves of the order itself, or were sold in the slave markets of the kingdom. The scarce records kept in the Archivo Histórico Nacional, section Órdenes Militares, referring to slaves, help to understand the development of traffic, work and manumission of these people.

    Las órdenes militares dispusieron desde su fundación de mano de obra esclava en sus tierras, pero la institución que mejor sirve para estudiar la esclavitud en los siglos XII y XIII en los reinos de León y Castilla son los hospitales para la redención de cautivos de la Orden de Santiago. Estas instituciones disponían de espacio para alojar a los cautivos mientras se negociaban rescates con los poderes islámicos, y atendían a la redistribución de aquellos musulmanes que, por no haber sido redimidos, pasaban a ser esclavos de la propia orden o a ser vendidos en los mercados de los reinos cristianos. Los escasos documentos de la sección de Órdenes Militares del Archivo Histórico Nacional dedicados a esclavos ayudan a comprender el funcionamiento del tráfico, trabajo y liberación de este colectivo.

  2. Fundamentos constructivos de las fortificaciones fronterizas entre las coronas de Castilla y Aragón de los siglos XII al XV en la actual provincia de Soria

    OpenAIRE

    2013-01-01

    La tesis doctoral desarrolla una investigación original, dentro del marco disciplinario de la historia de la construcción, sobre los fundamentos constructivos de las fortificaciones bajomedievales fronterizas entre las Coronas de Castilla y Aragón en la actual provincia de Soria. En el título de la tesis ya queda expresado el objeto fundamental y fundacional, así como el ámbito temporal —desde la reconquista del oriente soriano por parte de Alfonso I el Batallador a principios del siglo XII h...

  3. Conflictividad social castellano-leonesa y Feudalismo en el siglo XII : una reflexión sobre el caso de Castrojeriz

    OpenAIRE

    Larrañaga Zulueta, Miguel

    1999-01-01

    El artículo es una breve nota, situado en un marco de mayores discursiones de conflictividad social que acontecen a principios del siglo XII, a la invasión almorávide hay que añadir una etapa política muy inestable en los reinos cristianos. Las disputas sociales que se recogen en diversas fuentes se refieren al hecho de forzar el reconocimiento de los privilegios feudales concedidos a las villas frente al avance de los señoríos laicos y eclesiásticos, se trataría de mantener una situación de ...

  4. "Penuria pauperum clamat".Discursos letrados sobre los bienes eclesiásticos (Siglos XII-XVI): doctrinas ideales y realidades típicas

    OpenAIRE

    Rafael M. Pérez García

    2014-01-01

    Este trabajo estudia los orígenes y el desarrollo de los discursos letrados sobre los bienes eclesiásticos entre los siglos XII y XVI. Generados en el marco de los procesos reformistas que se producen en la Iglesia durante este arco de tiempo, estos discursos acabaron conformando las mentalidades sociales sobre el clérigo ideal y su relación con los bienes materiales. This article studies the origins and development of the highbrow literature about the ecclesiastical properties...

  5. Research Progress on Group-XII Secreted Phospholipase A2%分泌型磷脂酶A2-XII的研究进展

    Institute of Scientific and Technical Information of China (English)

    许媛媛; 叶波平

    2011-01-01

    Group-XII secreted phospholipase A2 (sPLA2 - XII) includes two isoforms: sPLA2 - XIIA and sPLA2 - XIIB. They are present only in animals and their primary sequence, distribution and functions are markedly different from other PLA2s. The catalytic activity of sPLA2 - XIIA is very weak, yet it can kill Gram-negative bacteria efficiently. However sPLA2 - IIB is the first mammalian secreted phospholipase A2 that is completely devoid of enzymatic activity. Strong expression was observed in liver, small intestine, and kidney in both human and mouse species. Interestingly, the expression of SPLA2 - XIIBs dramatically decreased in tumors from the same tissues, which suggest that sPLA2 - XIIB probably play an important role in tumorigenesis. The study on sPLA2 - XIIs' structure, distribution and pharmaceutical application, which provide the theoretical basis for further investigations and applications of sPLA2 - XII, was reviewed in this paper.%分泌型磷脂酶A2-XII包括A、B 2个亚型,存在于多种动物的组织和细胞中,在结构、分布与功能上明显异于其他磷脂酶,其中的分泌型磷脂酶A2-XIIA酶活性较低,但具有很强的抗革兰氏阴性菌作用,而分泌型磷脂酶A2-XIIB是首个发现于哺乳动物的完全没有酶活性的分泌型磷脂酶亚型,在人和小鼠的肝脏、小肠和肾脏中含量最高,而在这些组织对应的肿瘤中表达下调,推测其在这些肿瘤发生过程中发挥重要作用.文章综述了分泌型磷脂酶A2-XII的结构、分布以及在药学中的应用,为进一步开发其药用价值提供理论依据.

  6. Hegel y Aristóteles: Una lectura de Metafísica XII, 7,1072b 18-30

    Directory of Open Access Journals (Sweden)

    Luis Xavier López-Farjeat

    2013-11-01

    Full Text Available The author does a hegelian interpretation of Metaphysics XII, 7, 1072b 18-30, passage with which the Encyclopedia of the Philosophical Sciences concludes. Here are drawn the relations and similitudes that exist between Aristotle's Unmoved Mover and Hegel's Absolute. In order to understand in which points both thinkers coincide when describing divine thought, it is highly important to analyze the notions of thought, movement, power, act, concept, object, material substance, formal substance and suprasensible substance. The interpretative turn that Hegel does of Metaphysics and the comparative reading here offered, point towards a better understanding of the nature of the Unmoved Mover and the Absolute.

  7. MOJAVE XII: Acceleration and Collimation of Blazar Jets on Parsec Scales

    CERN Document Server

    Homan, D C; Kovalev, Y Y; Pushkarev, A B; Savolainen, T; Kellermann, K I; Richards, J L; Ros, E

    2014-01-01

    We report on the acceleration properties of 329 features in 95 blazar jets from the MOJAVE VLBA program. Nearly half the features and three-quarters of the jets show significant changes in speed and/or direction. In general, apparent speed changes are distinctly larger than changes in direction, indicating that changes in the Lorentz factors of jet features dominate the observed speed changes rather than bends along the line of sight. Observed accelerations tend to increase the speed of features near the jet base, $\\lesssim 10-20$ parsecs projected, and decrease their speed at longer distances. The range of apparent speeds at fixed distance in an individual jet can span a factor of a few, indicating that shock properties and geometry may influence the apparent motions; however, we suggest that the broad trend of jet features increasing their speed near the origin is due to an overall acceleration of the jet flow out to de-projected distances of order $10^2$ parsecs, beyond which the flow begins to decelerate ...

  8. A history of late and very late stent thrombosis is not associated with increased activation of the contact system, a case control study

    Directory of Open Access Journals (Sweden)

    Brügger-Andersen Trygve

    2010-04-01

    Full Text Available Abstract Background The pathophysiological pathways resulting in Late Stent Thrombosis (LST remain uncertain. Findings from animal studies indicate a role of the intrinsic coagulation pathway in arterial thrombus formation, while clinical studies support an association with ischemic cardiovascular disease. It is currently unknown whether differences in the state of the contact system might contribute to the risk of LST or Very Late Stent Thrombosis (VLST. We assessed the relation between levels of several components involved in the contact system and a history of LST and VLST, termed (VLST in a cohort of 20 patients as compared to a matched control group treated with PCI. Methods and Results Activated factor XII (FXIIa, FXII zymogen (FXII, FXIIa-C1-esterase inhibitor (C1-inhibitor, Kallikrein-C1-inhibitor, FXIa-C1-inhibitor and FXIa-α1-antitrypsin (AT-inhibitor complexes were measured by Enzyme-linked immunosorbent assy (ELISA methodology. Cases and controls showed similar distributions in sex, age, baseline medications and stent type. Patients with a history of (VLST had a significantly greater stent burden and a higher number of previous myocardial infarctions than the control patients. There were no significant between-group differences in the plasma levels of the components of the contact system. Conclusion In a cohort of patients with a history of (VLST, we did not observe differences in the activation state of the intrinsic coagulation system as compared to patients with a history of percutaneous coronary intervention without stent thrombosis.

  9. Arterial thrombosis is accelerated in mice deficient in histidine-rich glycoprotein.

    Science.gov (United States)

    Vu, Trang T; Zhou, Ji; Leslie, Beverly A; Stafford, Alan R; Fredenburgh, James C; Ni, Ran; Qiao, Shengjun; Vaezzadeh, Nima; Jahnen-Dechent, Willi; Monia, Brett P; Gross, Peter L; Weitz, Jeffrey I

    2015-04-23

    Factor (F) XII, a key component of the contact system, triggers clotting via the intrinsic pathway, and is implicated in propagating thrombosis. Although nucleic acids are potent activators, it is unclear how the contact system is regulated to prevent uncontrolled clotting. Previously, we showed that histidine-rich glycoprotein (HRG) binds FXIIa and attenuates its capacity to trigger coagulation. To investigate the role of HRG as a regulator of the intrinsic pathway, we compared RNA- and DNA-induced thrombin generation in plasma from HRG-deficient and wild-type mice. Thrombin generation was enhanced in plasma from HRG-deficient mice, and accelerated clotting was restored to normal with HRG reconstitution. Although blood loss after tail tip amputation was similar in HRG-deficient and wild-type mice, carotid artery occlusion after FeCl3 injury was accelerated in HRG-deficient mice, and HRG administration abrogated this effect. To confirm that HRG modulates the contact system, we used DNase, RNase, and antisense oligonucleotides to characterize the FeCl3 model. Whereas DNase or FVII knockdown had no effect, carotid occlusion was abrogated with RNase or FXII knockdown, confirming that FeCl3-induced thrombosis is triggered by RNA in a FXII-dependent fashion. Therefore, in a nucleic acid-driven model, HRG inhibits thrombosis by modulating the intrinsic pathway of coagulation.

  10. Factor XI Deficiency Alters the Cytokine Response and Activation of Contact Proteases during Polymicrobial Sepsis in Mice.

    Directory of Open Access Journals (Sweden)

    Charles E Bane

    Full Text Available Sepsis, a systemic inflammatory response to infection, is often accompanied by abnormalities of blood coagulation. Prior work with a mouse model of sepsis induced by cecal ligation and puncture (CLP suggested that the protease factor XIa contributed to disseminated intravascular coagulation (DIC and to the cytokine response during sepsis. We investigated the importance of factor XI to cytokine and coagulation responses during the first 24 hours after CLP. Compared to wild type littermates, factor XI-deficient (FXI-/- mice had a survival advantage after CLP, with smaller increases in plasma levels of TNF-α and IL-10 and delayed IL-1β and IL-6 responses. Plasma levels of serum amyloid P, an acute phase protein, were increased in wild type mice 24 hours post-CLP, but not in FXI-/- mice, supporting the impression of a reduced inflammatory response in the absence of factor XI. Surprisingly, there was little evidence of DIC in mice of either genotype. Plasma levels of the contact factors factor XII and prekallikrein were reduced in WT mice after CLP, consistent with induction of contact activation. However, factor XII and PK levels were not reduced in FXI-/- animals, indicating factor XI deficiency blunted contact activation. Intravenous infusion of polyphosphate into WT mice also induced changes in factor XII, but had much less effect in FXI deficient mice. In vitro analysis revealed that factor XIa activates factor XII, and that this reaction is enhanced by polyanions such polyphosphate and nucleic acids. These data suggest that factor XI deficiency confers a survival advantage in the CLP sepsis model by altering the cytokine response to infection and blunting activation of the contact (kallikrein-kinin system. The findings support the hypothesis that factor XI functions as a bidirectional interface between contact activation and thrombin generation, allowing the two processes to influence each other.

  11. FOREWORD: The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009) The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) (Pine Mountain, Georgia, USA, 19-23 April 2009)

    Science.gov (United States)

    Orlando, Thomas M.; Diebold, Ulrike

    2010-03-01

    The 12th International Workshop on Desorption Induced by Electronic Transitions (DIET XII) took place from 19-23 April 2009 in Pine Mountain, Georgia, USA. This was the 12th conference in a strong and vibrant series, which dates back to the early 1980s. DIET XII continued the tradition of exceptional interdisciplinary science and focused on the study of desorption and dynamics induced by electronic excitations of surfaces and interfaces. The format involved invited lectures, contributed talks and a poster session on the most recent developments and advances in this area of surface physics. The Workshop International Steering Committee and attendees wish to dedicate DIET XII to the memory of the late Professor Theodore (Ted) Madey. Ted was one of the main pioneers of this field and was one of the primary individuals working to keep this area of science exciting and adventurous. His overall contributions to surface science were countless and his contributions to the DIET field and community were enormous. He is missed and remembered by many friends and colleagues throughout the world. The papers collected in this issue cover many of the highlights of DIET XII. Topics include ultrafast electron transfer at surfaces and interfaces, quantum and spatially resolved mapping of surface dynamics and desorption, photon-, electron- and ion-beam induced processes at complex interfaces, the role of non-thermal desorption in astrochemistry and astrophysics and laser-/ion-based methods of examining soft matter and biological media. Although the workshop attracted many scientists active in the general area of non-thermal surface processes, DIET XII also attracted many younger scientists (i.e., postdoctoral fellows, advanced graduate students, and a select number of advanced undergraduate students). This field has had an impact in a number of areas including nanoscience, device physics, astrophysics, and now biophysics. We believe that this special issue of Journal of Physics

  12. Genética de Coffea: XII - Hereditariedade da côr amarela da semente

    Directory of Open Access Journals (Sweden)

    A. Carvalho

    1949-01-01

    Full Text Available The known species of Coffea can be grouped into two categories according to the color of their endosperm which is either green or yellow. The commercially cultivated varieties of Coffea arabica L. and Coffea canephora Pierre ex Froehner are well known for the green color of their seed while the less known varieties of Coffea liberica Hiern and Coffea Dewevrei De Wild, et Th. Dur. have yellow Feed. In 1935, however, a yellow seeded type of C. arabica, was found in Brazil and has been described as Coffea arabica L. var. cera K.M.C. ; it is believed to have originated by mutation from Coffea arabica L. var. typica Cramer. In this paper the authors present the results of a genetic study of the yellow seeded mutant known as "cera". It has been found that in C. arabica, yellow endosperm is controlled by one pair of recessive factors cece. Hybrid seeds containing a Cece embryo were green (xenia, their endosperm being either Cecece or CeCece. Cera is a tetraploid variety and when it was crossed with diploid Coffea species having yellow endosperm, it was found to produce only yellow hybrid seeds. The cera, which is a yellow seeded mutant has been useful not only for definitely showing that the bulk of the coffee seed is true endosperm, but it has also proved useful is study of the biology of the coffee flower.

  13. [Electrophysiological monitoring of cranial motor nerves (V, VII, IX, X, XI, XII)].

    Science.gov (United States)

    Lefaucheur, J-P; Neves, D O; Vial, C

    2009-04-01

    In various neurosurgical operations, there is a risk of cranial nerve lesion that can be avoided or minimized with intraoperative electrophysiological monitoring. Regarding motor function of the cranial nerves, stimulodetection techniques are used, including electrical stimulation of nerve trunks and electromyographic recording of evoked motor responses. These techniques can be used for monitoring the trigeminal nerve (Vth cranial nerve), facial nerve (VIIth), glossopharyngeal nerve (IXth), pneumogastric nerve (Xth), spinal accessory nerve (XIth), and hypoglossal nerve (XIIth), in particular during surgical removal of tumors of the cerebellopontine angle or skull base. When beginning an operation, electrical stimulation is only used to identify the nerve structures. As removal of the tumor progresses, the goal is to verify that a surgical injury to the nerve is avoided by looking for the absence of any change regarding amplitude, morphology, and latency of motor responses. Intraoperative electromyographic monitoring can also be applied during the surgical treatment of primary hemifacial spasm by microvascular decompression. An effective decompression is usually associated with the disappearance of "lateral spread" motor responses to facial nerve branch stimulation. Therefore, the intraoperative disappearance of the lateral spread responses can be considered a predictive factor of good postoperative clinical outcome, even if this assertion remains a matter of debate.

  14. National Library of Norway's new database of 22 manuscript maps concerning the Swedish King Charles XII's campaign in Norway in 1716 and 1718

    Directory of Open Access Journals (Sweden)

    Benedicte Gamborg Brisa

    2003-03-01

    Full Text Available The National Library of Norway is planning to digitise approximately 1,500 manuscript maps. Two years ago we started working on a pilot project, and for this purpose we chose 22 maps small enough to be photographed in one piece. We made slides 6 x 7 cm in size, converted the slides into PhotoCDs and used four different resolutions on JPEG-files. To avoid large file sizes, we had to divide the version with the biggest resolution into four pieces. The preliminary work was done in Photoshop, the database on the web is made in Oracle. You can click on the map to zoom. Norwegians and probably Swedes during the Great Northern War drew the 22 maps when the Swedish King Charles XII in 1716 and 1718 unsuccessfully attempted to conquer Norway. The database is now accessible on the National Library of Norway's web site. The database is in Norwegian, but we are working on an English version as well. The maps are searchable on different topics, countries, counties, geographical names, shelfmarks or a combination of these. We are planning to expand the database to other manuscript maps later. This is the reason why it is possible to search for obvious subjects as Charles XII and the Great Northern War.

  15. Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.

    Science.gov (United States)

    Ibrahim, Diaa A; Lasheen, Deena S; Zaky, Maysoun Y; Ibrahim, Amany W; Vullo, Daniela; Ceruso, Mariangela; Supuran, Claudiu T; Abou El Ella, Dalal A

    2015-08-01

    A series of novel 2-aminobenzothiazole derivatives bearing sulfonamide at position 6 was designed, synthesized and investigated as inhibitors of four isoforms of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), the cytosolic CA I and II, and the tumor-associated isozymes CA IX and XII. Docking and binding energy studies were carried out to reveal details regarding the favorable interactions between the scaffolds of these new inhibitors and the active sites of the investigated CA isoforms. Most of the novel compounds were acting as highly potent inhibitors of the tumor-associated hCA IX and hCA XII with KIs in the nanomolar range. The ubiquitous and dominant rapid cytosolic isozyme hCA II was also inhibited with KIs ranging from 3.5 to 45.4 nM. The favorable interactions between some of the new compounds and the active site of different CA isoforms were delineated by using molecular docking which may be useful for designing compounds with high affinity and selectivity for some CAs with biomedical applications.

  16. Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, IX and XII with benzene sulfonamides incorporating 4- and 3-nitrophthalimide moieties.

    Science.gov (United States)

    Sethi, Kalyan K; Verma, Saurabh M; Tanç, Muhammet; Purper, Gaultier; Calafato, Gaetan; Carta, Fabrizio; Supuran, Claudiu T

    2014-03-01

    A series of 4 and 5 nitro-1,3-dioxoisoindolin-2-yl benzenesulfonamide derivatives (compounds 1-8) was synthesized by reaction of benzenesulfonamide derivatives with 4 and 3-nitrophthalic anhydrides. These new sulfonamides were investigated as inhibitors of the zinc metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) and more specifically against the human (h) cytosolic isoforms hCA I and II and the transmembrane, tumor-associated hCA IX and XII. Most of the novel compounds were medium potency-weak hCA I inhibitors (Kis in the range of 295-10,000 nM), but were more effective hCA II inhibitors (Kis of 1.7-887 nM). The tumor-associated hCA IX was also inhibited, with Kis in the micromolar range, whereas against hCA XII the inhibition constants were in the range of 90-3,746 nM. The structure-activity relationship (SAR) with this series of sulfonamides is straightforward, with the main features leading to good activity for each isoforms being established. The high sequence hCA alignment homology and molecular docking studies was performed in order to rationalize the activities reported and binding mode to different hCA as inhibitors. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. Levels of intrinsic coagulation factors and the risk of myocardial infarction among men: opposite and synergistic effects of factors XI and XII

    NARCIS (Netherlands)

    Doggen, Catharina Jacoba Maria; Rosendaal, Frits R.; Meijers, Joost C.M.

    2006-01-01

    The role of the intrinsic coagulation system on the risk of myocardial infarction is unclear. In the Study of Myocardial Infarctions Leiden (SMILE) that included 560 men younger than age 70 with a first myocardial infarction and 646 control subjects, we investigated the risk of myocardial infarction

  18. 2. XII avati Vaalas...

    Index Scriptorium Estoniae

    2005-01-01

    Soome kunstnike Tello Anttila, Lasse Kempase ja Jarmo Virmavirta näitus "Maagiline maastik". Väljas on suuremõõtmelised maastikku, iseäranis valgust ning põhjamaist ürgloomust käsitlevad akvarellid, õlimaalid ja puuskulptuurid. Näituse patroon Kristi Kallas

  19. 2. XII avati Vaalas...

    Index Scriptorium Estoniae

    2005-01-01

    Soome kunstnike Tello Anttila, Lasse Kempase ja Jarmo Virmavirta näitus "Maagiline maastik". Väljas on suuremõõtmelised maastikku, iseäranis valgust ning põhjamaist ürgloomust käsitlevad akvarellid, õlimaalid ja puuskulptuurid. Näituse patroon Kristi Kallas

  20. Collagen type XII and versican are present in the early stages of cartilage tissue formation by both redifferentating passaged and primary chondrocytes.

    Science.gov (United States)

    Taylor, Drew W; Ahmed, Nazish; Parreno, Justin; Lunstrum, Gregory P; Gross, Allan E; Diamandis, Eleftherios P; Kandel, Rita A

    2015-02-01

    Current approaches to cartilage tissue engineering require a large number of chondrocytes. Although chondrocyte numbers can be expanded in monolayer culture, the cells dedifferentiate and unless they can be redifferentiated are not optimal to use for cartilage repair. We took advantage of the differential effect of culture conditions on the ability of passaged and primary chondrocytes to form cartilage tissue to dissect out the extracellular matrix (ECM) molecules produced and accumulated in the early stages of passaged cell cartilage tissue formation as we hypothesized that passaged bovine cells that form cartilage accumulate a pericellular matrix that differs from cells that do not form cartilage. Twice passaged bovine chondrocytes (P2) (cartilage forming), or as a control primary chondrocytes (P0) (which do not generate cartilage), were cultured on three-dimensional membrane inserts in serum-free media. P2 redifferentiation was occurring during the first 8 days as indicated by increased expression of the chondrogenic genes Sox9, collagen type II, aggrecan, and COMP, suggesting that this is an appropriate time period to examine the ECM. Mass spectrometry showed that the P2 secretome (molecules released into the media) at 1 week had higher levels of collagen types I, III, and XII, and versican while type II collagen and COMP were found at higher levels in the P0 secretome. There was increased collagen synthesis and retention by P2 cells compared to P0 cells as early as 3 days of culture. Confocal microscopy showed that types XII, III, and II collagen, aggrecan, versican, and decorin were present in the ECM of P2 cells. In contrast, collagen types I, II, and III, aggrecan, and decorin were present in the ECM of P0 cells. As primary chondrocytes grown in serum-containing media, a condition that allows for the generation of cartilage tissue in vitro, also accumulate versican and collagen XII, this study suggests that these molecules may be necessary to provide a

  1. Exophytic pilocytic astrocytoma of the brain stem in an adult with encasement of the caudal cranial nerve complex (IX-XII): presurgical anatomical neuroimaging using MRI

    Energy Technology Data Exchange (ETDEWEB)

    Yousry, Indra; Yousry, Tarek A. [Department of Neuroradiology, Klinikum Grosshadern, Ludwig-Maximilians University, Marchioninistr. 15, 81377, Munich (Germany); Muacevic, Alexander; Olteanu-Nerbe, Vlad [Department of Neurosurgery, Klinikum Grosshadern, Ludwig-Maximilians University, Munich (Germany); Naidich, Thomas P. [Department of Radiology, Section of Neuroradiology, Mount Sinai Hospital, New York (United States)

    2004-07-01

    We describe a rare case of adult pilocytic astrocytoma in which exophytic growth from the brain stem presented as a right cerebellopontine angle mass. An initial MRI examination using T2- and T1-weighted images without and with contrast suggested the diagnosis of schwannoma. Subsequent use of 3D CISS (three-dimensional constructive interference in steady state) and T1-weighted contrast-enhanced 3D MP-RAGE (three-dimensional magnetization prepared rapid acquisition gradient echo) sequences led to the diagnosis of an exophytic brain stem tumor, documented the precise relationships of the tumor to cranial nerve VIII, revealed encasement of cranial nerves IX-XII (later confirmed intraoperatively), and provided the proper basis for planning surgical management. (orig.)

  2. The Joint International Conference of the XII International Conference on Mechanisms and Mechanical Transmissions (MTM) and the XXIII International Conference on Robotics (Robotics ’16)

    CERN Document Server

    Lovasz, Erwin-Christian; Hüsing, Mathias; Maniu, Inocentiu; Gruescu, Corina

    2017-01-01

    This volume presents the proceedings of the Joint International Conference of the XII International Conference on Mechanisms and Mechanical Transmissions (MTM) and the XXIII International Conference on Robotics (Robotics ’16), that was held in Aachen, Germany, October 26th-27th, 2016. It contains applications of mechanisms and transmissions in several modern technical fields such as mechatronics, biomechanics, machines, micromachines, robotics and apparatus. In connection with these fields, the work combines the theoretical results with experimental testing. The book presents reviewed papers developed by researchers specialized in mechanisms analysis and synthesis, dynamics of mechanisms and machines, mechanical transmissions, biomechanics, precision mechanics, mechatronics, micromechanisms and microactuators, computational and experimental methods, CAD in mechanism and machine design, mechanical design of robot architecture, parallel robots, mobile robots, micro and nano robots, sensors and actuators in ro...

  3. CT-clinical approach to patients with symptoms related to the V, VII, IX-XII cranial nerves and cervical sympathetics

    Energy Technology Data Exchange (ETDEWEB)

    Kalovidouris, A.; Mancuso, A.A.; Dillon, W.

    1984-06-01

    Forty-three patients who had signs and symptoms possibly related to the extracranial course of cranial nerves V, VII, IX, X-XII, and the cervical sympathetics were examined prospectively using high resolution CT to obtain images of thin sections during rapid drip infusion of contrast material. Anatomic areas in the scan protocols included the posterior fossa, cavernous and paranasal sinuses, skull base, temporal bone, nasopharynx, parotid gland, tongue base, and neck. Nine of the 23 patients with possible fifth nerve deficits had extracranial structural lesions that explained the symptoms; none of these nine, however, had typical trigeminal neuralgia. Of eight patients with peripheral seventh nerve abnormalities, two had positive findings on scans. Of five patients presenting with referred ear pain, three had carcinoma of the upper aerodigestive tract. The authors' experience suggests that patients at high risk for structural lesions responsible for cranial nerve deficits can be selected by clinical criteria. Protocols for each clinical setting are presented.

  4. Pengaruh Kompetensi Pedagogik dan Kompetensi Profesional Guru terhadap Economic Literacy melalui Prestasi Belajar Siswa Kelas XII IPS di SMA Kota Malang

    Directory of Open Access Journals (Sweden)

    Denik Wulandari

    2013-10-01

    Full Text Available Tujuan penelitian ini untuk menguji pengaruh (1 kompetensi pedagogik guru terhadap economic literacy melalui prestasi belajar siswa, (2 kompetensi profesional guru terhadap economic literacy melalui prestasi belajar siswa. Penelitian dilakukan terhadap siswa kelas XII IPS di SMA RSBI se-Kota Malang pada tahun 2012, data diperoleh dari angket, tes, dan dokumentasi. Hasil pene-litian: (1 kompetensi pedagogik guru berpengaruh positif signifikan terhadap economic literacy; (2 kompetensi pedagogik guru berpengaruh positif signifikan terhadap prestasi belajar; (3 prestasi belajar berpengaruh positif signifikan terhadap economic literacy; (4 kompetensi profesional guru berpengaruh positif signifikan terhadap economic literacy; dan (5 kompetensi profesional guru berpengaruh positif signifikan terhadap prestasi belajar. Berdasarkan hasil penelitian tersebut secara keseluruhan dapat diketahui bahwa kompetensi pedagogik dan kompetensi profesional guru dapat mempengaruhi economic literacy siswa melalui prestasi belajar siswa. Kata kunci: kompetensi pedagogik, kompetensi profesional, prestasi belajar, economic literacy

  5. Pesca y trabajo en el reino de Toledo. La cuenca alta y media del Tajo en los siglos XII al XVI

    Directory of Open Access Journals (Sweden)

    Sánchez Quiñones, Julián

    2006-06-01

    Full Text Available

    This work treats about the professions related with the fishing in the Kingdom of Toledo, in the high and middle course of river Tagus, from XII-XVIth centuries. Along these pages we have seen many different kind of people, public servants, great merchants, workers of the fisheries, involved in the fishing, trading and delivering of fish in this time. So with this article, we break with the idea which identified the fishing only with fishing men and boats showing how the medieval society was interested in every economic activity which produced profits.



    Este trabajo trata acerca de las profesiones relacionadas con la pesca en el Reino de Toledo, en la cuenca alta y media del río Tajo, de los siglos XII al XVI. A lo largo de estas páginas hemos visto muchos tipos diferentes de personas, oficiales públicos, grandes mercaderes, trabajadores de las pesquerías, envueltos en la captura, comercio y distribución del pescado. Con este artículo, queremos romper con la idea que identifica la pesca sólo con los pescadores y los barcos, mostrando como la sociedad medieval se interesaba en cualquier actividad económica que produjese beneficios.

  6. Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isoforms I and II and transmembrane, tumor-associated isoforms IX and XII with boronic acids.

    Science.gov (United States)

    Winum, Jean-Yves; Innocenti, Alessio; Scozzafava, Andrea; Montero, Jean-Louis; Supuran, Claudiu T

    2009-05-15

    A series of aromatic, arylalkenyl- and arylalkyl boronic acids were assayed as inhibitors of four physiologically relevant carbonic anhydrase (CA, EC 4.2.1.1) isoforms, the cytosolic human (h) hCA I and II, and the transmembrane, tumor-associated hCA IX and XII. The best hCA I and II inhibitor was biphenyl boronic acid with, a K(I) of 3.7-4.5 microM, whereas the remaining derivatives showed inhibition constants in the range of 6.0-1560 microM for hCA I and of 6.0-1050 microM for hCA II, respectively. hCA IX and XII were effectively inhibited by most of the aromatic boronic acids (K(I)s of 7.6-12.3 microM) whereas the arylalkenyl and aryl-alkyl derivatives generally showed weaker inhibitory properties (K(I)s of 34-531 microM). The nature of the moiety substituting the boronic acid group strongly influenced the CA inhibitory activity, with inhibitors possessing low micromolar to millimolar activity being detected in this small series of investigated compounds. This study proves that the B(OH)(2) moiety represents a new zinc-binding group for the generation of effective CA inhibitors targeting isoforms with medicinal chemistry applications. The boronic acids probably bind to the Zn(II) ion within the CA active site leading to a tetrahedral geometry of the metal ion and of the B(III) derivative.

  7. O frontal do altar de Nedstryn e o mito de Heráclio na Noruega medieval (séculos XII-XIV

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    Guilherme Queiroz de Souza

    2016-10-01

    Full Text Available Esta pesquisa aborda as manifestações do mito do imperador Heráclio (c. 575-641 na Noruega medieval (séculos XII-XIV. Alguns fatos marcam profundamente a trajetória desse governante bizantino e corroboram a relevância do tema: a vitória contra o rei persa Cósroes II e a recuperação da cidade sagrada de Jerusalém e da relíquia da Santa Cruz (630. Juntamente com a Europa feudal, a Noruega foi uma região que mitificou a história sobre os feitos de Heráclio, cuja representação alternou entre a soberba e a humildade – do soberano triunfante ao imitator Christi em busca da Restitutio Crucis. Neste trabalho, cotejamos os indícios textuais do mito com as imagens do frontal do altar da igreja de Nedstryn (início do século XIV, nossa principal fonte que será alvo de uma análise iconográfica. Elaborados nos séculos XII-XIII, os vestígios textuais são dois: a Historia de Antiquitate Regum Norwagiensium, de Theodoricus Monachus, e o Gammelnorsk homiliebok. Com isso, objetivamos compreender de que maneira o mito heracliano expressou-se em terras norueguesas.

  8. PENGARUH HASIL BELAJAR MATA PELAJARAN PRODUKTIF AKUNTANSI, PROGRAM PRAKTIK KERJA INDUSTRI DAN SELF EFFICACY TERHADAP KESIAPAN KERJA SISWA KELAS XII PROGRAM KEAHLIAN AKUNTANSI DI SMK NEGERI 1 KENDAL TAHUN AJARAN 2013/2014

    Directory of Open Access Journals (Sweden)

    Noviana Noviana

    2013-02-01

    Full Text Available Sekolah Menengah Kejuruan merupakan lembaga pendidikan yang menghasilkan lulusan untuk siap kerja sesuai dengan bidang keahliannya. Kondisi di SMK Negeri 1 Kendal Tahun Ajaran 2012/2013 terdapat 66,67% atau 34 siswa yang bekerja diluar bidang akuntansi. Tujuan penelitian ini untuk mengetahui pengaruh hasil belajar mata pelajaran produktif akuntansi, program praktik kerja industri, dan self efficacy terhadap kesiapan kerja siswa kelas XII program keahlian akuntansi di SMK Negeri 1 Kendal Tahun Ajaran 2013/2014 baik secara parsial maupun simultan. Jenis penelitian ini adalah uji pengaruh dengan pendekatan kuantitatif. Populasi penelitian ini adalah seluruh siswa kelas XII program keahlian akuntansi sejumlah 105 siswa. Metode pengumpulan data menggunakan metode dokumentasi dan metode angket/kuesioner. Metode analisis data menggunakan analisis deskriptif, analisis regresi berganda, uji koefisien determinasi (R2, uji simultan (F, dan uji parameter individual (t. Hasil penelitian ini adalah secara parsial ada pengaruh hasil belajar mata pelajaran produktif akuntansi sebesar 25,70%, program praktik kerja industri sebesar 23,20%, dan self efficacy sebesar 32,90% terhadap kesiapan kerja siswa kelas XII. Sedangkan secara simultan ada pengaruh hasil belajar mata pelajaran produktif akuntansi, program praktik kerja industri, dan self efficacy terhadap kesiapan kerja siswa kelas XII program keahlian akuntansi di SMK Negeri 1 Kendal Tahun Ajaran 2013/2014 sebesar 43,10%. Vocational High School is an educational institution that produces graduates ready to work according to their expertise. Conditions at SMK Negeri 1 Kendal Academic Year 2012/2013 there are 66.67 % or 34 students working beyond the field of accounting The purpose of this study was to determine the effect of the learning outcomes of productive subjects accounting, on the job training program, and self-efficacy on job readiness class XII students accounting skills program at SMK Negeri 1 Kendal

  9. EFEKTIVITAS METODE DRILL BERBANTUAN MODUL PEMBELAJARAN DALAM UPAYA MENINGKATKAN HASIL BELAJAR SISWA KOMPETENSI DASAR JURNAL KHUSUS PERUSAHAAN DAGANG PADA SISWA KELAS XII IPS SMA NEGERI 10 SEMARANG TAHUN AJARAN 2013/2014

    Directory of Open Access Journals (Sweden)

    Meta Aditya Handayani

    2013-11-01

    Full Text Available Tujuan penelitian untuk mengetahui penerapan metode drill berbantuan modul dapat meningkatkan hasil belajar akuntansi kompetensi dasar Jurnal Khusus kelas XII IPS SMA Negeri 10 Semarang tahun ajaran 2013/2014 . Penelitian ini menggunakan metode quasi eksperimen. Populasi dalam penelitian ini adalah seluruh kelas XII IPS SMA Negeri 10 Semarang Tahun Ajaran 2013/2014. Metode pengumpulan data yaitu dengan menggunakan tes dan observasi. Pengujian hipotesis menggunakan uji paired sample t-tets dan independent sample t-test. Hasil penelitian menunjukkan peningkatan hasil belajar pada kelas eksperimen dilihat dari 61,16 meningkat mencapai 80,89. Selain itu menunjukkan hasil rata-rata nilai post-test sebesar 80,89 pada kelas eksperimen lebih tinggi dibandingkan nilai post-test sebesar 77,29 pada kelas kontrol. Berdasarkan hasil penelitian dapat disimpulkan bahwa pembelajaran dengan menggunakan metode pembelajaran drill berbantuan modul dapat meningkatkan hasil belajar serta efektif dalam meningkatkan hasil belajar siswa k ompetensi dasar jurnal khusus. Research purposes to determine the application of assisted modules drill method to improve learning outcomes of accounting competence base class XII IPS Special Journal SMA Negeri 10 Semarang school year 2013/2014. This study uses a quasi-experimental methods. The population in this study were all class XII IPS SMA Negeri 10 Semarang Academic Year 2013/2014. Data collection method is by using tests and observation. Hypothesis testing using paired sample t-tets and independent sample t-test. Results showed improved learning outcomes seen in the experimental classes increased to 80.89 from 61.16. In addition it shows the results of the average post-test score of 80.89 in the experimental class higher than the post -test score of 77.29 in the control class. Based on the results of this study concluded that learning by using drill -assisted learning modules to improve learning outcomes and effective in imp

  10. Roma ante el cambio dinástico en la monarquía española. La consulta de Carlos II a Inocencio XII sobre la sucesión

    Directory of Open Access Journals (Sweden)

    David Martín Marcos

    2007-04-01

    Full Text Available The problems derivated from the lack of Charles II’descendants affected the whole Europe at the end of the seventeenth century. In Italy this crisis was lived with particular intensity because an important part of its territories were controlled by the Spanish Monarchy. This article studies the role of Rome, as temporal and spiritual power, in the query maded to Innocent XII by Charles II in 1700 about the Spanish sucession.

  11. PENGARUH MOTIVASI, PRESTASI BELAJAR, STATUS SOSIAL EKONOMI ORANG TUA DAN LINGKUNGAN SEKOLAH TERHADAP MINAT MELANJUTKAN PENDIDIKAN KE PERGURUAN TINGGI PADA SISWA KELAS XII AKUNTANSI SMK NEGERI 1 KENDAL

    Directory of Open Access Journals (Sweden)

    Khoerunisa Fitriani

    2013-02-01

    Full Text Available Tujuan penelitian ini adalah untuk mengetahui apakah terdapat pengaruh positif motivasi, prestasi belajar, status sosial ekonomi dan lingkungan sekolah terhadap minat melanjutkan pendidikan ke perguruan tinggi pada siswa kelas XII akuntansi SMK Negeri 1 Kendal baik secara simultan maupun parsial. Populasi dalam penelitian ini seluruh siswa kelas XII akuntansi di SMK Negeri 1 Kendal (105 siswa. Pengambilan sampel dilakukan secara undian dengan metode proportional random sampling, dengan jumlah responden sebanyak 84 siswa. Metode pengumpulan data yaitu dokumentasi dan angket. Metode analisis data yang digunakan adalah deskriptif dan pengujian hipotesis menggunakan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa motivasi, prestasi belajar, status sosial ekonomi dan lingkungan sekolah berpengaruh 91,7% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara simultan. Motivasi berpengaruh 8,07% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial, prestasi belajar berpengaruh 39,56% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial, status sosial ekonomi orang tua berpengaruh 21,53% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial. Serta lingkungan sekolah berpengaruh 25,50% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial. The purpose of this research is to determine the level of positive influence between motivation, academic achievement, socio economic status of parents and school environment on interest in continuing education to the college of 12th Accounting Students at Vocational High School 1 of Kendal. Populations that used in this research is students at Vocational High School 1 of Kendal specially 12th accounting students (105 students. Lottery and proportional random sampling method is used to take the sample, which has total 84 students. Methods of the data collection is documentation and questionnaire. Methods of data

  12. Hubungan Asupan Energi Sarapan terhadap Tingkat Konsentrasi pada Siswa-Siswi Kelas XII SMA Negeri 1 Padang Tahun Ajaran 2013/2014

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    Kurnia Maidarmi Handayani

    2014-09-01

    Full Text Available AbstrakIndonesia menduduki peringkat terakhir dalam cognitive skills dan pencapaian pendidikan menurut penelitian yang dilakukan oleh Economist Intelligence Unit. Cognitive skills memerlukan fungsi otak yang adekuat yang dipertahankan oleh nutrisi berupa konsumsi pangan yang baik dan beragam, terutama sarapan. Penelitian di Amerika Serikat pada anak usia sekolah remaja (15-18 tahun menunjukkan bahwa sebesar 30% remaja tidak biasa sarapan. Penelitian ini bertujuan untuk mengetahui hubungan antara asupan energi sarapan dan tingkat konsentrasi pada siswa SMAN 1 Padang. Studi dilakukan di SMAN 1 Padang pada bulan November 2013 terhadap 116 siswa kelas XII. Desain penelitian bersifat analitik dengan desain cross sectional. Pengolahan data dilakukan dengan uji chi-square menggunakan sistem komputerisasi. Hasil penelitian menunjukkan terdapat perbedaan tingkat konsentrasi menggunakan digit symbol test antara siswa dengan asupan energi sarapan baik, kurang, dan sangat kurang (p=0,001 dan tidak terdapat perbedaan tingkat konsentrasi menggunakan digit span test antara siswa dengan asupan energi sarapan baik, kurang, dan sangat kurang (p=0,345. Terdapat hubungan yang bermakna antara asupan energi sarapan dengan tingkat konsentrasi menggunakan digit symbol test (p<0,05.Kata kunci: sarapan, asupan energi, konsentrasi, digit symbol test, digit span testAbstractIndonesia was ranked last in the cognitive skills and educational attainment according to research conducted by the Economist Intelligence Unit.Cognitive skills require brain function is maintained by adequate intake of nutrients such as good and varied food, especially breakfast. Research in the United States in children of school age youth (15-18 years showed that 30% of teenagers are not usually did breakfast.This study aimed to determine the relationship between energy intake at breakfast and the level of concentration of students of SMAN 1 Padang. The study was conducted at SMAN 1 Padang in

  13. PENGARUH BIMBINGAN KARIR DAN LINGKUNGAN SEKOLAH MELALUI MOTIVASI KERJA TERHADAP KESIAPAN KERJA SISWA KELAS XII KOMPETENSI KEAHLIAN AKUNTANSI SMK NEGERI 2 MAGELANG

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    Muhammad Zachim Alfan

    2013-02-01

    Full Text Available Kesiapan kerja merupakan keseluruhan kondisi individu yang meliputi kematangan fisik, mental dan pengalaman serta adanya kemauan dan kemampuan untuk melaksanakan suatu pekerjaan atau kegiatan. Tujuan dari penelitian ini adalah untuk mengetahui ada tidaknya pengaruh bimbingan karir dan lingkungan sekolah melalui motivasi terhadap kesiapan kerja siswa kelas XII SMK Negeri 2 Magelang. Populasi penelitian ini adalah siswa kelas XII Kompetensi Keahlian Akuntansi SMK Negeri 2 Magelang Tahun Ajaran 2013/2014. Jumlah sampel sebanyak 84 siswa yang diambil dengan menggunakan rumus Isaac. Pengambilan sampel tiap kelas menggunakan proporsional random sampling. Metode pengumpulan data adalah angket. Metode analisis data menggunakan teknik analisis deskriptif, regresi linear berganda dan analisis jalur. Hasil penelitian menunjukkan bahwa terdapat pengaruh bimbingan karir terhadap kesiapan kerja siswa (48,1%, lingkungan sekolah berpengaruh terhadap kesiapan kerja siswa (33,5%, bimbingan karir berpengaruh terhadap motivasi kerja siswa (30,5%, ada pengaruh lingkungan sekolah terhadap motivasi kerja siswa (27%, bimbingan karir melalui motivasi kerja berpengaruh terhadap kesiapan kerja siswa (50,8%, dan lingkungan sekolah melalui motivasi kerja berpengaruh terhadap kesiapan kerja siswa (35,9%. The working readiness is the entire condition of an individual including physical maturity, mental maturity, experiential maturity, the existence of willingness and capability to do a job or activity. The purpose of this study is to know whether there is influence of career guidance and environmental school through motivation toward the working readiness of the twelfth graders who are taking accountancy program at State Vocational High School 2 Magelang. In this research, the population was the twelfth graders with year of education 2013/2014 who are taking accountancy program at State Vocational High School 2 Magelang. The population was the twelfth graders with year of

  14. PENGARUH KUALITAS POLA ASUH ORANG TUA, CARA BELAJAR, DAN MOTIVASI BELAJAR TERHADAP PRESTASI BELAJAR AKUNTANSI SISWA KELAS XI DAN XII KOMPETENSI KEAHLIAN AKUNTANSI SMK GATRA PRAJA KOTA PEKALONGAN TAHUN PELAJARAN 2013/2014

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    Eva Yulianti

    2014-11-01

    Full Text Available Prestasi belajar dipengaruhi oleh beberapa faktor, diantaranya yaitu kualitas pola asuh orang tua, cara belajar, dan motivasi belajar. Prestasi belajar akuntansi di SMK Gatra Praja Kota Pekalongan masih rendah. Masih ada 57 % siswa belum mencapai KKM yang ditetapkan sekolah yaitu ≥70. Tujuan penelitian ini untuk mengetahui adanya pengaruh kualitas pola asuh orang tua, cara belajar, dan motivasi belajar akuntansi di SMK Gatra Praja Kota Pekalongan baik secara parsial maupun simultan. Penelitian ini merupakan penelitian kuantitatif. Metode pengumpulan data menggunakan metode dokumentasi dan metode kuesioner. Metode analisis data menggunakan deskriptif persentase, regresi berganda, uji F, uji t, koefisien determinasi simultan(R2 dan koefisien determinasi parsial (r2. Hasil penelitian ini adalah secara parsial ada pengaruh kualitas pola asuh orang tua sebesar 16,2 %, cara belajar sebesar 6,4%, dan motivasi belajar sebesar 6,2% terhadap prestasi belajar akuntansi. Sedangkan secara simultan ada pengaruh kualitas pola asuh orang tua, cara belajar, dan motivasi belajar akuntansi di SMK Gatra Praja Kota Pekalongan tahun ajaran 2013/2014 sebesar 51,1%. Learning achievement is influenced by several factors, among which are quality of parents parenting, learning style, and learning motivation. Learning achievement of Accounting subjects in SMK Gatra Praja Pekalongan City is still low. There are still 57% students have not reached the KKM which has been established by the school is ≥70. The purpose of this study is to investigate the influence of quality of parents parenting, learning style, and learning motivation toward the learning achievement of Accounting subjects either partially or simultaneously. This research is quantitative research. Methods of data collection which are used are documentation and questionnaire method. Methods of data analysis using descriptive percentages, multiple regression, F test, t tes , and simultaneous determination

  15. Estrategias de subsistencia en los momentos finales del Pleistoceno medio: el nivel XII de la Cova del Bolomor (La Valldigna, Valencia

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    Ruth BLASCO

    2009-08-01

    Full Text Available RESUMEN: La Cova del Bolomor, situada en Tavernes de la Valldigna (Valencia, ofrece uno de los mejores registros faunísticos de la segunda mitad del Pleistoceno medio de la Península Ibérica. La cavidad contiene un relleno sedimentario formado por diecisiete niveles estratigráficos que abarcan desde el OIS 9 al OIS 5e. Esta amplia secuencia cronológica permite abordar diferentes cuestiones relacionadas con los grupos humanos de este periodo y sus relaciones con el medio ambiente. Concretamente, a partir del estudio zooarqueológico del nivel XII (OIS 6, se ha reconstruido la secuencia antrópica de obtención y procesamiento de los recursos faunísticos. De este modo, se han identificado diferentes estrategias de subsistencia llevadas a cabo por los homínidos para la obtención de los animales. Estas técnicas van desde el carroñeo hasta la caza e incluyen el aprovisionamiento de pequeñas presas como las aves (Cygnus olor o los lepóridos (Oryctolagus cuniculus. Esta variabilidad de estrategias podría interpretarse como la gran capacidad de adaptación que poseen estos grupos humanos para aprovechar las oportunidades que el medio les ofrece. También se ha observado la existencia de patrones bien sistematizados tanto en el aprovechamiento de los recursos faunísticos externos (piel, carne, tendones como en la obtención de los recursos internos (médula. Muchos de los elementos diagnósticos que evidencian la fracturación antrópica en el nivel XII presentan cierta sistematización en zonas y partes anatómicas concretas. La existencia de morfologías repetidas en algunos elementos esqueléticos indica una cierta estandarización a la hora de fracturar los huesos. Esta reiteración podría implicar la existencia de mecanismos de aprendizaje o de transmisión de información intergrupal por parte de los grupos humanos del Pleistoceno medio final. En general, este estudio pretende aportar datos sobre las estrategias de subsistencia de

  16. Homens de letras e homens de leis ao serviço da monarquia portuguesa (séculos XII-XIII

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    Armando Norte

    2014-06-01

    Full Text Available Ao longo da primeira dinastia, os letrados ao serviço da Coroa portuguesa desempenharam um papel decisivo e cada vez mais importante na afirmação do poder real. Homens de leis e homens de letras serviram à casa real como oficiais, representaram os reis portugueses em atos políticos e diplomáticos e exerceram um grande leque de funções na esfera da administração central - políticas, jurídicas, médicas, económicas, administrativas. A presença desses elementos ao lado dos monarcas fez-se sentir desde a fundação do reino, logo desde o reinado de D. Afonso Henriques, coincidindo o corolário deste processo de recrutamento com a chegada de D. Afonso III ao trono, numa política continuada, de forma firme, por D. Dinis. O conjunto de eruditos recenseados junto dos reis portugueses da época fundacional constitui, nessa medida, um interessante estudo de caso para compreender, em parte, em que consistia um círculo áulico, à luz dos valores do século XII e XIII.

  17. Preliminary report on AED deployment on the entire Air France commercial fleet: a joint venture with Paris XII University Training Programme.

    Science.gov (United States)

    Bertrand, C; Rodriguez Redington, P; Lecarpentier, E; Bellaiche, G; Michel, D; Teiger, E; Morris, W; Le Bourgeois, J P; Barthout, M

    2004-11-01

    The positive effect of early defibrillation on survival from cardiac arrest has been demonstrated. We describe the use of AEDs over 1 year following the training of flight attendants. Air France and the University of Paris XII together designed a 1 year training programme for 14000 flight attendants. The university emergency departments (SAMU) provided 250 instructors. AEDs training and certification was conducted for crew members between November 2001 and November 2002. By January 2003, all aircraft were fully equipped with AEDs. All cases of cardiac arrest that occurred during the study were reviewed comprehensively. Comments from the crew were collected. Twelve cardiac arrests were reported between November 2002 and November 2003 out of 4194 cases of emergency care delivered to passengers. Shock treatment was advised initially in 5/12 cases. The survival rate after in-flight cardiac arrest was 3/12. The survival rate at discharge from hospital following in flight shock was 2/5. No complications arose from the use of AEDs. Training by professionals gave the flight attendants confidence and allowed for the survival of two young passengers. Our study highlights the ability of flight attendants to give better onboard care for the future. The next step is to consolidate the network between in-flight care and the medical dispatch centre in Paris.

  18. A probable case of gigantism/acromegaly in skeletal remains from the Jewish necropolis of "Ronda Sur" (Lucena, Córdoba, Spain; VIII-XII centuries CE).

    Science.gov (United States)

    Viciano, Joan; De Luca, Stefano; López-Lázaro, Sandra; Botella, Daniel; Diéguez-Ramírez, Juan Pablo

    2015-01-01

    Pituitary gigantism is a rare endocrine disorder caused by hypersecretion of growth hormone during growing period. Individuals with this disorder have an enormous growth in height and associated degenerative changes. The continued hypersecretion of growth hormone during adulthood leads to acromegaly, a condition related to the disproportionate bone growth of the skull, hands and feet. The skeletal remains studied belong to a young adult male from the Jewish necropolis of "Ronda Sur" in Lucena (Córdoba, Spain, VIII-XII centuries CE). The individual shows a very large and thick neurocranium, pronounced supraorbital ridges, an extremely prominent occipital protuberance, and an extremely large and massive mandible. Additional pathologies include enlargement of the vertebral bodies with degenerative changes, thickened ribs, and a slight increased length of the diaphysis with an increased cortical bone thickness of lower limbs. Comparative metric analysis of the mandible with other individuals from the same population and a contemporary Mediterranean population shows a trend toward acromegalic morphology. This case is an important contribution in paleopathological literature because it is a rare condition that has not been widely documented in ancient skeletal remains.

  19. Experimental arterial thrombosis in genetically or diet induced hyperlipidemia in rats--role of vitamin K-dependent clotting factors and prevention by low-intensity oral anticoagulation.

    Science.gov (United States)

    De Curtis, A; D'Adamo, M C; Amore, C; Polishchuck, R; Castelnuovo, A D; Donati, M B; Iacoviello, L

    2001-12-01

    To investigate the relationship among lipids, coagulation and thrombosis in the absence of atherosclerosis, spontaneous or dietary-induced hyperlipidemic (FHL) rats were studied. FHL showed higher levels of coagulation factors VII, IX, X, VIII and XII and a shortening of the occlusion time (OT) of an artificial arterial prosthesis as compared with normolipidemic (FNL) animals. Damage of abdominal aorta of FHL was followed by increased fibrin deposition in the vascular intima as compared to FNL. After 5 months of cholesterol-rich diet FNL showed increased cholesterol, triglycerides and factor II, VII, IX, X, XII levels. A significant shortening of the OT and increased fibrin deposition was also observed. Two-month diet withdrawal restored the initial condition. Warfarin treatment, at a dose decreasing vitamin K-dependent factor to levels found in FNL, prolonged the OT and reduced fibrin deposition, without modifying F XII or changing lipid profile. An increase in the activated form of F VII was observed. In contrast, no difference was found in F VII clearance. High lipid levels favour the process of thrombus formation by increasing the activation of vitamin K-dependent coagulation factors. Low-dose warfarin treatment reverts the prothrombotic effect of hyperlipidemia.

  20. Studies in Reaction to Disability. XII: Structure of Attitudes toward the Physically Disabled; Disability Factor Scales--Amputation, Blindness, Cosmetic Conditions.

    Science.gov (United States)

    Siller, Jerome; And Others

    To describe and to develop instruments to measure attitudes toward amputees, the blind, and those with cosmetic conditions, three groups of subjects responded to one of three large pools of items tapping attitudes toward the three disability conditions. Three new groups of about 500 subjects of diverse demographic characteristics were given one of…

  1. Evaluación de Resúmenes enviados al Congreso de Córdoba 2008 Evaluation of the abstracts sent to the XII Congress of Cordoba

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    Ricardo Luis Videla

    2008-09-01

    Full Text Available Objetivo: Mostrar las debilidades y fortalezas de los resúmenes enviados al XII Congreso de Córdoba. Material y Método: Los resúmenes se dividieron en Científicos y Educativos. Los Científicos debían confeccionarse con: Introducción, Material y Método, Resultados y Conclusión. Los Educativos: Introducción, Objetivo, Revisión del tema y Conclusión. Máximo de caracteres 2.200. Resultados: Se recibieron 61 resúmenes, 18 Científicos, 43 Educativos. Se rechazó uno Científico que no mostraba casuística. De los 60 aceptados el 58 % no respetó el reglamento de confección. En 4 casos no había introducción; en 6, no había objetivos, en 13 no había conclusiones; en 4, faltas gruesas de ortografía y en 8 se superaban los caracteres reglamentarios (más de 2400 caracteres. En 11 casos se anticipaba lo que iban a exponer sin desarrollar el tema y por lo tanto fueron clasificados como "resúmenes que no dicen nada". Conclusiones: Las debilidades de los resúmenes fueron: no respeto del reglamento, resúmenes que no decían nada, exceso de palabras y errores de ortografía. Las fortalezas de los resúmenes fueron: importante cantidad de residentes que realizaron trabajos, participación de médicos del interior y la calidad científica y educativa de la mayoría de los resúmenes.Objective: To show the weaknesses and strengths of the abstract sent to the XII Congress of Cordoba. Material and Methods: The abstracts were divided into Scientifics and Educational. Scientifics should be made with: Introduction, Material and Method, Results and Conclusion. Educators: Introduction, Objectives, Revision of the theme and Conclusion. Maximum 2,200 characters. Results: There were 61 abstracts, 18 Scientifics, 43 educatives. A scientific abstract was rejected because of lock of casuistic. Of the 60 accepted 58% did not respect the rules. In 4 cases there were no introduction, there were no objectives in 6, 13 had not conclusions, 4 had great

  2. A Keck/DEIMOS spectroscopic survey of the faint M31 satellites AndIX, AndXI, AndXII and AndXIII†

    Science.gov (United States)

    Collins, M. L. M.; Chapman, S. C.; Irwin, M. J.; Martin, N. F.; Ibata, R. A.; Zucker, D. B.; Blain, A.; Ferguson, A. M. N.; Lewis, G. F.; McConnachie, A. W.; Peñarrubia, J.

    2010-10-01

    We present the first spectroscopic analysis of the faint M31 satellite galaxies, AndXI and AndXIII, as well as a re-analysis of existing spectroscopic data for two further faint companions, AndIX (correcting for an error in earlier geometric modelling that caused a misclassification of member stars in previous work) and AndXII. By combining data obtained using the Deep Imaging Multi-Object Spectrograph (DEIMOS) mounted on the Keck II telescope with deep photometry from the Suprime-Cam instrument on Subaru, we have identified the most probable members for each of the satellites based on their radial velocities (precise to several down to i ~ 22), distance from the centre of the dwarf spheroidal galaxies (dSphs) and their photometric [Fe/H]. Using both the photometric and spectroscopic data, we have also calculated global properties for the dwarfs, such as systemic velocities, metallicities and half-light radii. We find each dwarf to be very metal poor ([Fe/H] ~ -2 both photometrically and spectroscopically, from their stacked spectrum), and as such, they continue to follow the luminosity-metallicity relationship established with brighter dwarfs. We are unable to resolve dispersion for AndXI due to small sample size and low signal-to-noise ratio, but we set a 1σ upper limit of σv financial support of the W.M. Keck Foundation. Based in part on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. ‡ E-mail: mlmc2@ast.cam.ac.uk

  3. Galaxy pairs in the Sloan Digital Sky Survey - XII: The fuelling mechanism of low excitation radio-loud AGN

    CERN Document Server

    Ellison, Sara L; Hickox, Ryan C

    2015-01-01

    We investigate whether the fuelling of low excitation radio galaxies (LERGs) is linked to major galaxy interactions. Our study utilizes a sample of 10,800 spectroscopic galaxy pairs and 97 post-mergers selected from the Sloan Digital Sky Survey with matches to multi-wavelength datasets. The LERG fraction amongst interacting galaxies is a factor of 3.5 higher than that of a control sample matched in local galaxy density, redshift and stellar mass. However, the LERG excess in pairs does not depend on projected separation and remains elevated out to at least 500 kpc, suggesting that major mergers are not their main fuelling channel. In order to identify the primary fuelling mechanism of LERGs, we compile samples of control galaxies that are matched in various host galaxy and environmental properties. The LERG excess is reduced, but not completely removed, when halo mass or D4000 are included in the matching parameters. However, when BOTH M_halo and D4000 are matched, there is no LERG excess and the 1.4 GHz lumin...

  4. La concesión del titulo de (I conde de Buendía por el rey Alfonso XII de Castilla (1465 como expresión del poder del linaje Acuña

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    Dolores Carmen Morales Muñiz

    2006-01-01

    Full Text Available La concesión del título de I conde de Buendía por el rey Alfonso XII de Castilla permite analizar una doble realidad en un contexto de dualidad monárquica (1465- 68. Primerante remite a la importancia del linaje Acuña beneficiario de la merced en la persona de Pedro de Acuña. La concesión demuestra la condición de monarca del joven Alfonso: sólo el rey puede expedir títulos nobiliarios. El hecho de que más adelante, la reina Isabel confirme el acto, ratifica la condición de su hermano como legítimo rey.The granting, on the part of the king of Castille Alfonso XII of the title of count of Buendía allows for an analysis of the double reality that from 1465 to 1468 existed in the context of a dual monarchy. The grant stressed the relevance of the Acuña lineage favored in the person of Pedro de Acuña. But of far larger relevance, the title likewise evidences the condition of king that young Alfonso had at the time as only the monarch could grant nobility titles. The ratification of that concession later on by queen Isabella I further santioned her brother’s legitimacy as king.

  5. Measurement of Blood Coagulation Factor Synthesis in Cultures of Human Hepatocytes.

    Science.gov (United States)

    Heinz, Stefan; Braspenning, Joris

    2015-01-01

    An important function of the liver is the synthesis and secretion of blood coagulation factors. Within the liver, hepatocytes are involved in the synthesis of most blood coagulation factors, such as fibrinogen, prothrombin, factor V, VII, IX, X, XI, XII, as well as protein C and S, and antithrombin, whereas liver sinusoidal endothelial cells produce factor VIII and von Willebrand factor. Here, we describe methods for the detection and quantification of most blood coagulation factors in hepatocytes in vitro. Hepatocyte cultures indeed provide a valuable tool to study blood coagulation factors. In addition, the generation and expansion of hepatocytes or hepatocyte-like cells may be used in future for cell-based therapies of liver diseases, including blood coagulation factor deficiencies.

  6. Observações citológicas em Coffea: XII - Uma nova forma tetraplóide

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    A. J. T. Mendes

    1949-01-01

    develop and one frequently encounters empty or only-one-seeded fruits. It is suggested that the sterility of the ovule and pollen grains may be due to the same factors.

  7. International Congress on Glass XII

    Energy Technology Data Exchange (ETDEWEB)

    Doremus, R H; LaCourse, W C; Mackenzie, J D; Varner, J R; Wolf, W W [eds.

    1980-01-01

    A total of 158 papers are included under nine headings: structure and glass formation; optical properties; electrical and magnetic properties; mechanical properties and relaxation; mass transport; chemical durability and surfaces; nucleation; crystallization; and glass ceramics; processing; and automatic controls. Separate abstracts were prepared for eight papers; four of the remaining papers had been processed previously for the data base. (DLC)

  8. Radiation Effects on Polymers - XII

    DEFF Research Database (Denmark)

    El-Awady, N. I.; Ghanem, N. A.; Pedersen, Walther Batsberg

    1979-01-01

    Calibration of gel permeation chromatography was carried out to determine molecular weight and molecular weight distribution of the side-chains and homopolymer formed during grafting of cellulose acetate with acrylamide monomer using accelerated electrons. Polyacrylamide in side-chains and in hom...

  9. Laser Spectroscopy : XII International Conference

    CERN Document Server

    Allegrini, Maria; Sasso, Antonio

    1996-01-01

    This text includes all the recent advances in the field of laser spectroscopy. Major results span from the control of matter by electromagnetic fields (trapping and coding) to high precision measurements on simple atomic systems and to quantum optics with single atoms. It includes a report of the Bose-Einstein condensation achieved by laser-cooling of rubidium atoms. Achievements in the technology of tunable sources, in particular of miniaturized solid state devices, are also reported. Most recent advances in molecular spectroscopy are illustrated with emphasis on "cooled" spectra, clusters and high accuracy frequency references. Topics such as atomic interferometry and microcavity quantum optics are also covered.

  10. Vides de Simón de Rojas Clemente (1777-1827 en el herbario del Real Colegio Alfonso XII de San Lorenzo de El Escorial (Madrid, España

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    Perea, Domingo

    1997-12-01

    Full Text Available In the present paper, the discovery of grape-vine mounted sheets from the Simón de Rojas Clemente herbarium, which were found in the Herbarium of the Real Colegio Alfonso XH in San Lorenzo de El Escorial, is reported. This material completes the collection of Clemente's vines which makes up one of the historical collections deposited in the MA herbarium.Damos a conocer unos pliegos de vides procedentes del herbario de Simón de Rojas Clemente que han aparecido en el Gabinete de Ciencias Naturales del Real Colegio Alfonso XII de San Lorenzo de El Escorial. Estos materiales completan la colección de vides de Clemente que constituye uno de los herbarios históricos depositados en MA.

  11. Morfología dental y distancias biológicas entre tres grupos funerarios prehispánicos asociados a la tradición cultural Sonso del Valle del Cauca, Colombia (siglos X al XII d.c.

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    Rodríguez Flores, Carlos D.

    2005-01-01

    Full Text Available Estudios arqueológicos sobre poblaciones prehispánicas del sur occidente colombiano sugieren que existe una continuidad cultural expresada en los patrones de cultura material. La biología de la población que perteneció a la tradición cultural Sonso aún no se conoce. Por esta razón, no se han formulado aún hipótesis sobre la condición biológica y genética de este grupo humano prehispánico y sus orígenes asociados a patrones de poblamiento y adaptación en esta región de Colombia. Se describe la variación morfológica y el patrón dental intragrupal de la población prehispánica excavada en el Municipio de Yumbo, Departamento del Valle del Cauca en Colombia y portadora de la tradición cultural Sonso ubicada en el durante los siglos XI y XII d.C. Mediante la observación de la prevalencia de 51 rasgos en la morfología coronal de dientes temporales y permanentes se determinan las relaciones biológicas entre los miembros de los grupos funerarios y se infieren relaciones genéticas e históricas entre los integrantes de esta población. Se encontró que el patrón morfológico de algunos rasgos cambia a entre los siglos X y XII d.C. Esto es explicado como resultado de posible contacto con otros grupos provenientes del sur.

  12. How Do R&D Programs Funded by the Dg Xii (Science, Research and Development Directorate of the European Commission Impact the Upstream Oil and Gas Industry in Europe? Comment les programmes de R&D financés par la DG XII de la Commission européenne influencent-ils l'industrie pétrolière amont en Europe ?

    Directory of Open Access Journals (Sweden)

    Forbes P.

    2006-12-01

    Full Text Available This paper provides an overview of the direct and indirect impact which DG XII funding for research and development has on the oil and gas exploration and production industry in Europe. Despite the relatively low level of funding, the impact is quite significant. These impacts are presented using a bottom-up analysis, starting with the impact of technology on industry and society, the impact of research on technology, and the impact of DG XII funding on both research and technology for the exploration and production of oil and gas. The different aspects that are discussed include the direct impact, the impact on R&D organization and management, and the impact due to the Commission demonstration program for oil and gas (Thermie. Examples are provided from current and past project results. The future impact on the industry, and Commission policy toward the oil and gas sector are suggestedIn the near future, it is expected that there will be greater impact on production technologies, on the contribution of oil and gas companies to long-term R&D, and on the transfer of results to the Commission demonstration program. L'article apporte une vue d'ensemble sur la manière dont les financements de la DG XII pour la recherche et le développement (R&D ont une influence, directe ou indirecte, sur l'exploration et la production dans l'industrie du pétrole et du gaz en Europe. Le niveau de ces financements est présenté comme relativement faible de façon à mettre en évidence que, comparativement, leur répercution est très significative. L'impact de ces financements est abordé en couvrant successivement les effets sur la société, l'industrie, la technologie et finalement la recherche elle-même. Nous décrivons ici les influences de la technologie sur l'industrie et sur la société, puis les influences de la recherche sur la technologie et enfin celles des financements de la DG XII sur la recherche et la technologie en exploration-production. Diff

  13. Disputes i compromisos entre l'església de Girona i la noblesa: Notes d'unes difícils relacions. Segles XI i XII

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    Salrach, Josep M.

    1999-12-01

    Full Text Available In this article are studied the disputes or conflicts between the ecclesiastic hierarchy and the aristocracy of the country of Girona in the era of the feudal change. The sources of information are the documents of the XI-XII Century of the Chartulary call of "Carlemany", of the bishop of Girona, edited by J. M. Marqués, and the documents of the XI Century of the cathedral of Gerona, edited by R. Marti. The article is split into two parts of unequal extension. In the first, the shortest, it is summarised the problem of the relationships between the Church and the civil power in the Late Antiquity and the High Middle Ages, until the XIXII Century. The approach is general, European, but is ended this part carrying the problems to the case of Catalonia. It is a study of the context in the one which the author attempts to find the bases of the attitude of the feudal nobility in theirs disputes with the Church. In the second part of the article are studied the disputes and the engagements (more the first tan the seconds between the cathedral of Gerona and the nobility. The analysis and the description are not effected in a way concrete, examining a dispute after other, that is to say. there is no studies of cases with lineages and personages identification, because prevails the global vision and the will of identifying the principal disputes and the general and dominant reasons of each part. The questions that they have guided the investigation are: With what obstacles stumbled the reform of the Church? Which were the concrete causes of the disputes? How they were solved these disputes? Which were the political bases, material, spiritual and cultural on those which the Church of Gerona sustained their engagements with the nobility? How they were articulated these engagements? Turned out to be it a work that interprets the reform of the Church in the framework of the feudal change process, and arrives to the conclusion of the fact that the reform was

  14. F12-46C/T polymorphism as modifier of the clinical phenotype of hereditary angioedema.

    Science.gov (United States)

    Speletas, M; Szilágyi, Á; Csuka, D; Koutsostathis, N; Psarros, F; Moldovan, D; Magerl, M; Kompoti, M; Varga, L; Maurer, M; Farkas, H; Germenis, A E

    2015-12-01

    The factors influencing the heterogeneous clinical manifestation of hereditary angioedema due to C1-INH deficiency (C1-INH-HAE) represent one of the oldest unsolved problems of the disease. Considering that factor XII (FXII) levels may affect bradykinin production, we investigated the contribution of the functional promoter polymorphism F12-46C/T in disease phenotype. We studied 258 C1-INH-HAE patients from 113 European families, and we explored possible associations of F12-46C/T with clinical features and the SERPING1 mutational status. Given that our cohort consisted of related subjects, we implemented generalized estimating equations (GEEs), an extension of the generalized linear model accounting for the within-subject correlation. F12-46C/T carriers exhibited a significantly delayed disease onset (P < 0.001) and did not need long-term treatment (P = 0.02). In a GEE linear regression model, the presence of F12-46C/T was significantly associated with a 7-year delay in disease onset (P < 0.0001) regardless of SERPING1 mutational status. It is concluded that F12-46C/T carriage acts as an independent modifier of C1-INH-HAE severity.

  15. Proteins of the Hageman Factor System in an Inflammatory Reaction in the Acute Period of Severe Brain Injury

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    T. I. Borshchikova

    2010-01-01

    Full Text Available Objective: to study the time course of changes and an association of contact factors and their inhibitors with the global values of hemocoagulation, fibrinolysis, and inflammatory reactants in acute severe brain injury (SBI in order to deepen notions of Hageman factor system functioning. Subjects and methods. One hundred and thirteen patients with SBI were examined on 1 to 21 days of injury. The level of unconsciousness averaged a Glasgow coma score of 6.8±0.25. A control group included 23 healthy individuals. The investigators determined the activity of contact factors (prekallikrein, high-molecular-weight kininogen, factors XII, XI and their inhibitors (total activity of the protein C system, the activity and quantity of antithrombin III, C1 esterase inhibitor, a^antitrypsin, fl^-antiplasmin, fl^-macroglobulin, hemostatic parameters (blood fibrinolytic activity by an euglobulin test; factor XII-kallikrein-dependent fibrinolysis, treptokinase induced fibrinolysis by calculating the plasminogen reserve index, activated partial thromboplastin time, fibrinogen, D-dimer, and soluble fibrin monomer complexes, and inflammatory reactants (C-reactive protein, IL10, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, TNF-a, and IFN-y. Results. The acute period of SBI was marked by significant deficiency and imbalance of contact factors and their physiological inhibitors. In SBI, prekallikrein rather than factor XII plays a central role in the function of the contact factor system due to inflammatory inhibition of Hageman factor synthesis, which disturbs its key role in the reactions of contact activation of homeostatic proteolytic systems. Out of the considered systems, the activation of which is associated with contact factors, the function of the internal mechanism of fibrinolysis is largely changed; at the same time the internal hemocoagulation activation pathway remains virtually intact. When an inflammatory reaction develops after SBI, normal Hageman factor

  16. Consilium y fortalecimiento regio: consejeros y acción política regia en el reino de León en los siglos XI y XII

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    Fernando Luis Corral

    2011-11-01

    Full Text Available Este trabajo pretende ver la relación existente entre el acto de aconsejar y la realidad de la acción política regia en el reino leonés durante los siglos XI y XII. Como es sabido, el consejo formaba parte de los formulismos vasalláticos –consilium et auxilium– que definían la relación que se establecía entre la nobleza y la monarquía fundamentalmente a través de los juramentos de homenaje en los que la nobleza reconocía, al menos teóricamente, la superioridad del rey como su señor. El monarca, a su vez, por la fidelidad que los nobles le juraban controlaba sus movimientos aunque se veía obligado a recompensarles adecuadamente sus servicios para ganarse su apoyo. Pero a finales del siglo XII, estos formulismos vasalláticos de los que el consilium era un elemento importante se comenzaron a mostrar ineficaces para contrarrestar el poder político de la nobleza y sus movimientos cada vez más autónomos rompiendo su fidelitas con el rey. Paulatinamente la monarquía leonesa utilizó nuevas estrategias de control que, incorporando el Derecho Romano a sus formulaciones teóricas legales, la situó en una posición inmejorable para introducir elementos nuevos de organización y administración del territorio, como los tenentes y merinos regios. Éstas y otras actuaciones fueron determinantes en el fortalecimiento regio que experimentaron los monarcas leoneses durante el siglo XII.Ce travail porte sur le rapport entre l'acte de conseiller et la réalité de l'action politique royale dans le royaume de León au cours des XIe et XIIe siècles. Le conseil apparaît dans les formules qui, comme “consilium et auxilium”, définissent la relation entre la noblesse et la monarchie, essentiellement dans les serments accompagnant l'hommage vassalique et par lesquels la noblesse reconnaissait, du moins théoriquement, la supériorité du roi en tant que seigneur. Grâce à la fidélité que les nobles lui juraient, le monarque exer

  17. PENGARUH MOTIVASI, PRESTASI BELAJAR, STATUS SOSIAL EKONOMI ORANG TUA DAN LINGKUNGAN TEMAN SEBAYA TERHADAP MINAT MELANJUTKAN PENDIDIKAN KE PERGURUAN TINGGI PADA SISWA KELAS XII KOMPETENSI KEAHLIAN AKUNTANSI DI SMK NEGERI SE-KOTA SEMARANG TAHUN AJARAN 2014/

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    Nabila Kharisma

    2015-11-01

    Full Text Available Penelitian ini bertujuan untuk mengetahui apakah terdapat pengaruh positif motivasi, prestasi belajar, status sosial ekonomi dan lingkungan teman sebaya terhadap minat melanjutkan pendidikan ke perguruan tinggi pada siswa kelas XII kompetensi keahlian akuntansi di SMK Negeri se-Kota Semarang baik secara simultan maupun parsial. Populasi dalam penelitian ini adalah seluruh siswa kelas XII Kompetensi Keahlian Akuntansi di SMK Negeri se-Kota Semarang tahun ajaran 2014/2015 yang berjumlah 213 siswa. Metode pengambilan sampel menggunakan teknik proportional random sampling dengan jumlah responden sebanyak 135 siswa. Metode pengumpulan data menggunakan angket dan dokumentasi. Sedangkan metode analisis data yang digunakan adalah analisis deskriptif dan pengujian hipotesis menggunakan analisis regresi linier berganda. Hasil penelitian menunjukkan bahwa terdapat pengaruh motivasi, prestasi belajar, status sosial ekonomi orang tua, dan lingkungan teman sebaya secara simultan berpengaruh sebesar 71,5% terhadap minat melanjutkan pendidikan ke perguruan tinggi. Sedangkan motivasi berpengaruh sebesar 17,47% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial, prestasi belajar berpengaruh sebesar 23,91% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial , status sosial ekonomi orang tua berpengaruh sebesar 16,81% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial, dan lingkungan teman sebaya berpengaruh sebesar 10,50% terhadap minat melanjutkan pendidikan ke perguruan tinggi secara parsial. This research aims to determine the level of positive influence between motivation, academic achievement, socio economic status of parents and peers environment on interest in continuing education to the collage of 12th Accounting Program Students at State Vocational High School of Semarang City in 2014/2015. Populations in this research is students at State Vocational High School of Semarang city specially 12

  18. Gramíneas uruguayas de D. José Arechavaleta (1838-1912, en el Real Colegio Alfonso XII de San Lorenzo de El Escorial (Madrid, España

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    Carrasco, María A.

    2001-12-01

    Full Text Available The Royal Monastery of El Escorial was built in the xvi century by king Felipe U. In the part intended to be a college and seminary, the Real Colegio Alfonso XII was established in 1885. In this place, the treasures that had been accumulated for fíve hundred years, that carne from acquisitions, collections and donations, are stored. In this paper we present a small collection, of undeniable historical valué. It contains 186 Gramineae that were sent as a present to María Cristina, the Regent Queen of Spain, by the President of Uruguay on the occasion of the World Exhibition of Barcelona in 1888. The plants are part of the herbarium of the Flora Uruguaya of José Arechavaleta y Balparda [Santurce (España, 1838-Montevideo (Uruguay, 1912]. Some of the plants are annotated by Arechavaleta as new species, and some belong from the loc. clas. All this material is identified by Arechavaleta and J. Hackel.El Real Monasterio de El Escorial fue fundado en el siglo XVI por el rey Felipe n. En la parte dedicada a colegio-seminario se estableció en 1885 el Real Colegio Alfonso XII, donde están depositados todos los fondos que se han ido acumulando a lo largo de quinientos años, procedentes de adquisiciones, recolecciones y donaciones. En este trabajo presentamos una colección, pequeña pero de indudable valor histórico, de 186 Gramineae que fueron enviadas por el presidente del Uruguay a la reina regente de España con motivo de la Exposición Universal de Barcelona celebrada en 1888. Estos materiales son parte del herbario de la Flora Uruguaya de D. José Arechavaleta y Balparda [Santurce (España, 1838-Montevideo (Uruguay, 1912]. Algunas plantas están anotadas por Arechavaleta como especies nuevas -unas cuantas proceden de la localidad clásica- y todas ellas están identificadas por Arechavaleta o J. Hackel.

  19. El reinado del Cornificio y el exilio de las Musas. El filósofo educado en las Artes en la Antigüedad arcaica y en la Europa medieval hasta el siglo XII

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    Diego Pintado

    2016-12-01

    Full Text Available Este estudio describe y analiza el tránsito de un paradigma educativo (antiguo, clásico y medieval a un nuevo paradigma (el universitario, hacia el siglo XII. Se examina el origen y el desarrollo de un paradigma educativo y de formación que se remonta hasta la Grecia arcaica y que se mantuvo en vigencia en la Europa medieval hasta la creación de las universidades en el siglo XII. La tradición educativa de las artes liberales, conocida también como disciplinae cyclicae, es analizado como heredero directo de la tradición arcaica y pitagórica griega basada en la formación por las Musas. Se examinarán las similitudes y paralelismos entre las Musas y las Artes a la luz de la obra de Marciano Capela, De nuptis Philologiae et Mercuri. Luego se estudiará en modo conciso la figura del Cornificio, recreada por Juan de Salisbury en su Metalogicon, y se meditará sobre la relación de esta figura paradigmática y el contexto social, cultural, histórico, político y religioso que acaba dando lugar al nacimiento de los primeros estatutos universitarios. This paper treats the question of how the archaic and classical education paradigm is replaced by a new one based on institutionalization. It concerns about the origin and development of one education paradigm of schools, and the other paradigm, the institutional one, current and prevailing since the creation of the institution of university emerged about 12th century. The Liberal Arts education, also known as disciplinae cyclicae education, is analyzed according to the archaic and pithagoric greek tradition based on education by Muses. We will find similarities between Muses and Liberal Arts according to Martianus Capella’s work De nuptis Philologiae et Mercuri. Finally, we will observe this problem in John of Salisbury’ work Metalogicon and his central symbolic figure of the Cornificius.

  20. Armas y equipos en la marca superior de Al-Andalus. El reducto rural islámico de Solibernat (Lleida y su panoplia militar en la primera mitad del siglo XII

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    Rovira i Port, Jordi

    2006-12-01

    Full Text Available

    This work present and analyze in full detail the weapons collection and the military equipment of islamic’s garrison detached in first half of the XII century in rural redoubt of Solibernat (Torres de Segre, Lleida, a little multivalent’s emplacement with military and agricultural functions, a control point and relay of post horses situated near the Madina Larida, the modern town of Lleida. The findings in Solibernat show us that a mixed detachment with infantryman and cavalryman guarded this emplacement. This detachment had spears, perhaps javelins, crossbows with their darts, shields and knifes. This way, Solibernat and the near islamic’s redoubt of Zafranales (Fraga, show us an extensive range of military weapons collection correctly dated between 1075/1080 and 1149 in a very delimitated territory of Thaghr al-á’la, the Upper’s March of al-Andalus.



    Este artículo presenta y analiza en detalle la panoplia militar y el equipo metálico de la guarnición islámica que ocupaba a lo largo de la primera mitad del siglo XII el reducto rural de Solibernat (Torres de Segre, Lleida, un pequeño asentamiento polivalente con funciones militares y agropecuarias que formaba parte de los anillos de control y posta existentes alrededor de Madina Larida, la actual ciudad de Lleida. Los hallazgos de Solibernat permiten inferir que el asentamiento se hallaba custodiado por un destacamento mixto compuesto por infantes y jinetes dotados de un armamento constituido, entre otros elementos, por lanzas, quizás jabalinas, ballestas y sus correspondientes dardos, escudos y cuchillos. Así, Solibernat y el cercano reducto islámico de Zafranales en Fraga, nos ofrecen un amplio espectro de panoplia militar bien datada entre 1075/1080 y el año 1149 en un territorio muy delimitado del Thaghr al-á’la, la Marca Superior de al-Andalus.

  1. Alzheimer's beta-amyloid peptides can activate the early components of complement classical pathway in a C1q-independent manner.

    Science.gov (United States)

    Bergamaschini, L; Canziani, S; Bottasso, B; Cugno, M; Braidotti, P; Agostoni, A

    1999-03-01

    beta-Amyloid (beta-A) accumulates in the brain of patients with Alzheimer's disease (AD) and is presumably involved in the pathogenesis of this disease, on account of its neurotoxicity and complement-activating ability. Although assembly of beta-A in particular aggregates seems to be crucial, soluble non-fibrillar beta-A may also be involved. Non-fibrillar beta-A does not bind C1q, so we investigated alternative mechanisms of beta-A-dependent complement activation in vitro. On incubation with normal human plasma, non-fibrillar beta-A 1-42, and truncated peptide 1-28, induced dose-dependent activation of C1s and C4, sparing C3, as assessed by densitometric analysis of immunostained membrane after SDS-PAGE and Western blotting. The mechanism of C4 activation was not dependent on C1q, because non-fibrillar beta-A can still activate C1s and C4 in plasma genetically deficient in C1q (C1qd). In Factor XII-deficient plasma (F.XIId) the amount of cleaved C4 was about 5-10% less that in C1qd and in normal EDTA plasma; the reconstitution of F.XIId plasma with physiologic concentrations of F.XII resulted in an increased (8-15%) beta-A-dependent cleavage of C4. Thus our results indicate that the C1q-independent activation of C1 and C4 can be partially mediated by the activation products of contact system. Since the activation of contact system and of C4 leads to generation of several humoral inflammatory peptides, non-fibrillar beta-A might play a role in initiating the early inflammatory reactions leading to a multistep cascade contributing to neuronal and clinical dysfunction of AD brain.

  2. Alzheimer's β-amyloid peptides can activate the early components of complement classical pathway in a C1q-independent manner

    Science.gov (United States)

    Bergamaschini, L; Canziani, S; Bottasso, B; Cugno, M; Braidotti, P; Agostoni, A

    1999-01-01

    β-Amyloid (β-A) accumulates in the brain of patients with Alzheimer's disease (AD) and is presumably involved in the pathogenesis of this disease, on account of its neurotoxicity and complement-activating ability. Although assembly of β-A in particular aggregates seems to be crucial, soluble non-fibrillar β-A may also be involved. Non-fibrillar β-A does not bind C1q, so we investigated alternative mechanisms of β-A-dependent complement activation in vitro. On incubation with normal human plasma, non-fibrillar β-A 1-42, and truncated peptide 1–28, induced dose-dependent activation of C1s and C4, sparing C3, as assessed by densitometric analysis of immunostained membrane after SDS–PAGE and Western blotting. The mechanism of C4 activation was not dependent on C1q, because non-fibrillar β-A can still activate C1s and C4 in plasma genetically deficient in C1q (C1qd). In Factor XII-deficient plasma (F.XIId) the amount of cleaved C4 was about 5–10% less that in C1qd and in normal EDTA plasma; the reconstitution of F.XIId plasma with physiologic concentrations of F.XII resulted in an increased (8–15%) β-A-dependent cleavage of C4. Thus our results indicate that the C1q-independent activation of C1 and C4 can be partially mediated by the activation products of contact system. Since the activation of contact system and of C4 leads to generation of several humoral inflammatory peptides, non-fibrillar β-A might play a role in initiating the early inflammatory reactions leading to a multistep cascade contributing to neuronal and clinical dysfunction of AD brain. PMID:10193429

  3. Novelties in the Diagnosis and Treatment of Angioedema.

    Science.gov (United States)

    Cicardi, M; Suffritti, C; Perego, F; Caccia, S

    2016-01-01

    Angioedema is defined as local, noninflammatory, self-limiting edema that is circumscribed owing to increased leakage of plasma from the capillaries located in the deep layers of the skin and the mucosae. Two mediators, histamine and bradykinin, account for most cases of angioedema. Angioedema can occur with wheals as a manifestation of urticaria, and this form is frequently allergic. In the present review, we discuss nonallergic angioedema without wheals, which can be divided into 3 acquired and 4 hereditary forms. Histamine is the mediator in acquired angioedema of unknown etiology (idiopathic histaminergic acquired angioedema), whereas in other forms the main mediator is bradykinin. Angioedema can be caused by C1-inhibitor deficiency (C1-INH-hereditary angioedema and C1-INH-acquired angioedema), mutations in coagulation factor XII (FXII-hereditary angioedema), and treatment with angiotensin-converting enzyme inhibitors (ACEI-acquired angioedema). Etiology remains unclear in acquired angioedema (idiopathic nonhistaminergic acquired angioedema) and in 1 type of hereditary angioedema (hereditary angioedema of unknown origin). Several treatments are licensed for hereditary C1-INH deficiency. Plasma-derived and recombinant C1-INHs, the bradykinin receptor blocker icatibant, and the plasma kallikrein inhibitor ecallantide have been approved for on-demand treatment to reverse angioedema symptoms. Attenuated androgen and plasma-derived C1-INH are approved for prophylaxis.

  4. FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT BERWIRAUSAHA PADA SISWA KELAS XII SMK NEGERI 1 KANDEMAN KABUPATEN BATANG TAHUN 2011/2012

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    Fitriani Aprilia

    2012-10-01

    Full Text Available Interest in entrepreneurship is an encouragement, a sense of� interest and the availability of � the individual to conduct a business without fear of� the risk will occur. Secondary vocational schools are educational institutions that prepare students to be a human resources that ready to work and have capacity for work independently (entrepreneurial after graduate from this school. Factors originating from within the students and the factors that originate from outside is affecting interest in entrepreneurship. In this study population is 287 students. The samples are 74 students conducted by proportional random sampling. Independent variables exam- ined in this study were internal factors (X1 and external factors (X2. While the dependent variable is the interest in entrepreneurship (Y. The data was collected by questionnaires and documentation. The results of� descriptive research showed that the percentage of� interest in entrepreneurship is included in the high category, internal and external factors are included in either category. Partial internal factors have a significant influence of� 28.84%, while external factors also have a significant effect of� 7.34%. Variables simultaneously internal and external factors affect the interest of� entrepreneurship by 48.4%

  5. Los fines de la presencia de la Orden del Hospital en Castilla (Siglos XII y XIII = The objectives of the presence of the Order of the Hospital in Castile during the 12th and 13th Centuries

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    Carlos Barquero Goñi

    2015-06-01

    Full Text Available Las fuentes nos informan muy poco acerca de la suerte que tenían los recursos obtenidos por la Orden del Hospital de sus posesiones en la Corona de Castilla durante los siglos XII y XIII. Con toda seguridad lo primero en que debían utilizarse estas sumas era en el mantenimiento de todas las instalaciones y miembros de la Orden en Castilla y León. Lo que sobrase después de esto se habría de emplear en cuatro partidas distintas: aportaciones al convento central del Hospital en Oriente, actividad militar en la propia Corona de Castilla, desempeño de funciones asistenciales y propiamente hospitalarias, y soporte para algunas operaciones financieras.The sources provide us with scarce information on the use of resources obtained by the Order of the Hospital from its possessions in the Crown of Castile during the twelfth and thirteenth centuries. There is no doubt that this wealth was destined in the first place for the maintenance of all the facilities and members of the Order in Castile and Leon. What remained thereafter would be allocated to four different areas: Contributions to the central convent of the Hospital in the East; military activity within the Crown of Castile itself; coverage of welfare and specifically hospitaller functions; and support for certain financial operations.

  6. As parroquias do Porriño, Cans e Atios na documentación do mosteiro cisterciense de Santa María de Melón. Séculos XII e XIII

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    Gradín Fernández, Isis

    2011-12-01

    Full Text Available After the introduction and criteria of transcription, 31 papers are published from the twelfth and thirteenth centuries belonging to the Cistercian monastery of Santa Maria de Melon, specifically those that permit the reconstruction of old possessions, focusing on the current council of O Porriño -which was the monastery of San Miguel de Cans, absorbed by the cistercian monks of Melon. A paleographic and historical approximation of this documentation is done, which is complemented with the corresponding index of names and place names.

    [gl] Trala introducción e criterios de transcripción, edítanse 31 documentos dos séculos XII e XIII pertencentes ó mosteiro cisterciense de Santa María de Melón, concretamente aqueles que permiten reconstruír as antigas posesións –centradas sobre o actual concello de O Porriño- do que foi o mosteiro de San Miguel de Cans, absorvido polos monxes cistercienses de Melón. Faise unha aproximación paleográfica e histórica da documentación, que se complementa cos correspondentes índices onomásticos e toponímicos.

  7. Un infrecuente objeto de madera en el Túmulo Neolítico Monte Areo XII (Carreño, Spain : estudio arqueológico, anatómico y taxonómico

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    Díaz González, Tomás E.

    2009-01-01

    Full Text Available Monte Areo XII (Carreño, Asturias es un raro túmulo erigido a fines del V milenio a. de C. sobre una estructura de madera (una probable choza previamente incendiada. Como único elemento instrumental en el monumento neolítico, y gracias a su carbonización, se conservó una pequeña pieza de madera. Su estudio arqueológico, anatómico y taxonómico nos permite identificarla como una probable punta de flecha o arma similar elaborada a partir de una rama de roble. La excepcionalidad de este objeto leñoso en la prehistoria de la extensa región cantábrica da lugar a distintas consideraciones sobre el instrumental corruptible a partir del mesolítico y el habitual uso de los objetos de madera durante el neolítico. La revisión del túmulo y su estructura en troncos de roble propicia además distintas consideraciones sobre las llamadas "casas fúnebres" en distintos contextos prehistóricos e ibéricos.

  8. Mineralogy and technology of bricks used for the construction of the XII century ducal castle on the island of Ostrów Tumski, Wrocław (SW Poland)

    Science.gov (United States)

    Bartz, W.; Chorowska, M.

    2016-12-01

    The historic bricks from the ducal castle on Ostrów Tumski (Wrocław), one of the first brickwork structures in the Lower Silesia, which dates back to the XII and XIII century, were studied and characterised by a combination of classical petrographic studies (polarising microscopy), scanning microscopy, thermal analysis and X-ray diffraction. The combined results of these methods suggest that the firing temperature ranges from 950°C, through the most common temperatures of 850-900°C, to the infrequent temperatures below 750°C. Most of the bricks were fired under oxidising conditions, occasionally over a sequence of oxidising and reducing steps, resulting in a sandwich structure. The results indicate, that low-calcareous raw materials were used, presumably Miocene-Pliocene `flamy clays', exploited a few kilometres away from the castle and tempered with locally obtained sand from the Odra river. Only small differences have been recognized in: 1) clay to aplastic material ratio, 2) amount of accessory minerals, 3) grain-size distribution of aplastic materials, but no significant changes in the brick technology were observed. The observed variability corresponds well to the different constructing phases, identified previously on the basis of archaeological work. Thus, our work proves that a detailed mineralogical and petrological study may help to identify different construction phases in historic monuments.

  9. Regime de discurso e laços sociais: o silêncio e a escrita monástica na primeira metade do século XII

    Directory of Open Access Journals (Sweden)

    Gabriel de C. G. Castanho

    2016-06-01

    Full Text Available Resumo Momento de importante expansão urbana e econômica, o século XII foi também marcado por vozes que clamavam pelos desertos europeus. Social e religiosamente, esse foi um tempo marcado pela tensão entre a reestruturação da vida em comunidade e a valorização do isolamento eremítico. O aparecimento dos monges cartuxos (talvez a mais importante ordem eremítica medieval, ocorrido nesse contexto, oferece uma ocasião privilegiada para o estudo do que venho chamando de “monopólio da solidão” (o controle do isolamento pela Ecclesia. Pretendo aqui demonstrar como a escrita e o silêncio (ligados ao studium e à noção de comunicação “per litteras” constituem um verdadeiro “regime de discurso” responsável por solucionar dialeticamente a contradição existente entre o propositum eremítico de abandono do mundo e sua inserção na comunidade eclesial.

  10. El Monasterio de Lorvão y los confines de la Beira (siglos IX-XII. Apuntes sobre la memoria histórica de un espacio de contacto

    Directory of Open Access Journals (Sweden)

    Cyrille AILLET

    2011-02-01

    Full Text Available La Beira es un caso modélico para estudiar las áreas fronterizas de la Alta Edad Media ibérica. En este espacio, el flujo de los dominios que se sucedieron hasta finales del siglo XI contrasta con la estabilidad relativa del poblamiento cristiano autóctono. La reorganización del territorio después de la conquista cristiana ocurrida en 878 no llegó a borrar por completo las estructuras sociales anteriores. La vigencia de la onomástica árabo- romance parece traducir el mantenimiento de ciertos contactos con el sur andalusí. La segunda fase de dominio islámico (998-1064 confirma esta interpretación, estableciéndose al norte del Mondego una suerte de protectorado andalusí en una zona compuesta de un verdadero mosaico de micropoderes cristianos. Lorvão y otros monasterios sobrevivieron y se adaptaron al nuevo dominio. La reconquista de Coimbra en 1064 tampoco impulsó un cambio radical. Sin embargo, la presión del clero favorable a la reforma gregoriana promovió un proceso de latinización. El desarrollo de la cronística real y la compilación de cartularios acompañaron el proceso de remodelación social y cultural de los siglos XII y XIII.

  11. Isolation and characterization of bovine plasma prekallikrein (Fletcher factor).

    Science.gov (United States)

    Heimark, R L; Davie, E W

    1979-12-11

    Prekallikrein (Fletcher factor) has been purified from bovine plasma approximately 25 000-fold with an overall yield of 14%. Purification steps included ammonium sulfate fractionation and column chromatography on heparin-agarose, DEAE-Sephadex, CM-Sephadex, benzamidine-agarose, and arginine methyl ester-agarose. The purified protein was homogeneous as judged by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and amino-terminal sequence analysis. Bovine plasma prekallikrein is a glycoprotein with a molecular weight of 82 000 as determined by sedimentation equilibrium centrifugation. It contains 12.9% carbohydrate, including 6.2% hexose, 4.5% N-acetylglucosamine, and 2.2% N-acetylneuraminic acid. Prekallikrein is a single polypeptide chain with an amino-terminal sequence of Gly-Cys-Leu-Thr-Gln-Leu-Tyr-His-Asn-Ile-Phe-Phe-Arg-Gly-Gly. This sequence is homologous to the amino-terminal sequence of human factor XI (plasma thromboplastin antecedent). Both prekallikrein and kallikrein require kaolin to correct Fletcher factor deficient plasma. Kallikrein, however, has a specific activity 3.5 times greater than prekallikrein. Prekallikrein does not correct plasma deficient in factor XII (Hageman factor), factor XI, or high molecular weight kininogen (Fitzgerald factor).

  12. The Contact Activation System (CAS) in cord blood: Measurement of CAS components and comparison with mother's blood. A pilot study.

    Science.gov (United States)

    Uszyński, Mieczysław; Kuczyński, Jarosław; Żekanowska, Ewa; Uszyński, Waldemar

    2015-11-01

    Classical reference data concerning the coagulation system and fibrinolysis in fetuses and newborns date back to the 1990 s. Since that time a number of methodological or other improvements have been implemented, which may cast some doubt on timeliness of the data. The study objective was to measure the levels of Contact Activation System (CAS) components by antigen, i.e. factors XII and XI (FXII, FXI), prekallikrein (PK) and high molecular weight kininogen (HMWK) in cord blood and maternal blood. The study group consisted of 35 healthy parturient women with an uneventful pregnancy and birth. The samples of cord blood and maternal blood were obtained immediately after delivery, before clumping the umbilical cord. The CAS components were measured by immunoenzymatic method (ELISA). The median concentrations of CAS components in cord blood plasma and mother's plasma were as follow: FXII: 1.02 (0.60- 2.58) ng/mg protein vs. 0.94 (0.66-1.86) ng/mg protein (p>0.05); FXI: 2.71(0.03-8.0) ng/mg protein vs. 0.92 (0.03-10.44) ng/mg protein (p>0.05); PK: 168.78 (104.28-261.16) pg/mg protein vs. 113.44 (79.94-146.70) pg/mg protein (p>0.05); HMWK: 2169.45 (1530.64- 2539.83) ng/mg protein vs. 2857.96 (2541.52-3161.04) ng/mg protein (pblood of full-term and healthy fetuses were similar to those observed in mother's blood immediately after delivery. Only high molecular weight kininogen was found to be lower (accounting for 84% of the values noted in mothers). 2. Based on our measurements, we claim that the cited reference data concerning the contact factors in full-term and healthy newborns are underestimated; hence, new reference values need to be determined for each antigen and activity contact factor level. Copyright © 2015. Published by Elsevier Ltd.

  13. Valeria Añón (ed.), Historia de la conquista de México. Libro XII de la Historia general de las cosas de la Nueva España : Buenos Aires, Corregidor, 2016, Vía México, 250 páginas

    OpenAIRE

    2012-01-01

    Es de festejarse la aparición de un libro como el que hoy nos convoca. Me hace muy feliz estar en esta mesa, por lo que en primer lugar quiero agradecer a Clementina Battcock su invitación a la presentación de la edición argentina del Libro XII de la Historia general de las cosas de la Nueva España. Clementina, además, escribe las Notas histórico-filológicas del libro, indispensables para situar a un autor como fray Bernardino de Sahagún y conocer cuál fue el destino de su obra.

  14. Changes in Dietary Fat Content Rapidly Alters the Mouse Plasma Coagulation Profile without Affecting Relative Transcript Levels of Coagulation Factors.

    Directory of Open Access Journals (Sweden)

    Audrey C A Cleuren

    Full Text Available Obesity is associated with a hypercoagulable state and increased risk for thrombotic cardiovascular events.Establish the onset and reversibility of the hypercoagulable state during the development and regression of nutritionally-induced obesity in mice, and its relation to transcriptional changes and clearance rates of coagulation factors as well as its relation to changes in metabolic and inflammatory parameters.Male C57BL/6J mice were fed a low fat (10% kcal as fat; LFD or high fat diet (45% kcal as fat; HFD for 2, 4, 8 or 16 weeks. To study the effects of weight loss, mice were fed the HFD for 16 weeks and switched to the LFD for 1, 2 or 4 weeks. For each time point analyses of plasma and hepatic mRNA levels of coagulation factors were performed after overnight fasting, as well as measurements of circulating metabolic and inflammatory parameters. Furthermore, in vivo clearance rates of human factor (F VII, FVIII and FIX proteins were determined after 2 weeks of HFD-feeding.HFD feeding gradually increased the body and liver weight, which was accompanied by a significant increase in plasma glucose levels from 8 weeks onwards, while insulin levels were affected after 16 weeks. Besides a transient rise in cytokine levels at 2 weeks after starting the HFD, no significant effect on inflammation markers was present. Increased plasma levels of fibrinogen, FII, FVII, FVIII, FIX, FXI and FXII were observed in mice on a HFD for 2 weeks, which in general persisted throughout the 16 weeks of HFD-feeding. Interestingly, with the exception of FXI the effects on plasma coagulation levels were not paralleled by changes in relative transcript levels in the liver, nor by decreased clearance rates. Switching from HFD to LFD reversed the HFD-induced procoagulant shift in plasma, again not coinciding with transcriptional modulation.Changes in dietary fat content rapidly alter the mouse plasma coagulation profile, thereby preceding plasma metabolic changes, which

  15. Puerarin Attenuates Ovalbumin-Induced Lung Inflammation and Hemostatic Unbalance in Rat Asthma Model

    Directory of Open Access Journals (Sweden)

    Feng Dong

    2014-01-01

    Full Text Available Aim. We aimed to investigate and evaluate the preventive activity of puerarin on the ovalbumin-induced asthma rat model. Materials and Methods. Male Wistar rats were sensitized intraperitoneally on days 0, 7, and 14 and challenged to ovalbumin intratracheally on day 21. Groups of sensitized rats were treated randomly either with placebo, puerarin, dexamethasone, or puerarin combined with dexamethasone, from days 15 to 20. Inflammatory markers, including cell counts in bronchoalveolar lavage fluid (BALF, inflammatory cytokines, histopathology, and coagulation parameters, such as coagulation tests and the activity of coagulation factors, were analyzed. Results. Puerarin significantly inhibited the recruitment of inflammatory cells in BALF and lung tissue. At the same time, the release of IL-4, IL-10, and IFN-γ in serum and the expression of mRNAs in lung tissue homogenate were changed by puerarin. Administration of puerarin also effectively rectified the coagulation disorder in asthmatic rats, such as prothrombin time (PT (P<0.01, thrombin time (TT (P<0.05, fibrinogen (FIB (P<0.01,the activity of factor II (FII (P<0.01, the activity of factor V (FV (P<0.05, the activity of factor VII (FVII (P<0.05, the activity of factor X (FX (P<0.05, the activity of factor VIII (FVIII (P<0.01, the activity of factor IX (FIX (P<0.05, and the activity of factor XII (FXII (P<0.05. Conclusions. Our results provide a clue that puerarin was useful for the preventive of allergic airway disease in rodents.

  16. Mast Cell Coupling to the Kallikrein–Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease

    Directory of Open Access Journals (Sweden)

    Clarissa R. Nascimento

    2017-08-01

    Full Text Available During the course of Chagas disease, infectious forms of Trypanosoma cruzi are occasionally liberated from parasitized heart cells. Studies performed with tissue culture trypomastigotes (TCTs, Dm28c strain demonstrated that these parasites evoke neutrophil/CXCR2-dependent microvascular leakage by activating innate sentinel cells via toll-like receptor 2 (TLR2. Upon plasma extravasation, proteolytically derived kinins and C5a stimulate immunoprotective Th1 responses via cross-talk between bradykinin B2 receptors (B2Rs and C5aR. Awareness that TCTs invade cardiovascular cells in vitro via interdependent activation of B2R and endothelin receptors [endothelin A receptor (ETAR/endothelin B receptor (ETBR] led us to hypothesize that T. cruzi might reciprocally benefit from the formation of infection-associated edema via activation of kallikrein–kinin system (KKS. Using intravital microscopy, here we first examined the functional interplay between mast cells (MCs and the KKS by topically exposing the hamster cheek pouch (HCP tissues to dextran sulfate (DXS, a potent “contact” activator of the KKS. Surprisingly, although DXS was inert for at least 30 min, a subtle MC-driven leakage resulted in factor XII (FXII-dependent activation of the KKS, which then amplified inflammation via generation of bradykinin (BK. Guided by this mechanistic insight, we next exposed TCTs to “leaky” HCP—forged by low dose histamine application—and found that the proinflammatory phenotype of TCTs was boosted by BK generated via the MC/KKS pathway. Measurements of footpad edema in MC-deficient mice linked TCT-evoked inflammation to MC degranulation (upstream and FXII-mediated generation of BK (downstream. We then inoculated TCTs intracardiacally in mice and found a striking decrease of parasite DNA (quantitative polymerase chain reaction; 3 d.p.i. in the heart of MC-deficient mutant mice. Moreover, the intracardiac parasite load was significantly reduced in WT

  17. Ressenya a Delle Donne, Fulvio & Torró, Jaume (eds. L’immagine di Alfonso il Magnanimo tra letteratura e storia, tra Corona d’Aragona e Italia - La imatge d’Algons el Magnànim en la literatura i la Historiografia entre la Corona d’Aragó i Itàlia, Florència, SISMEL -Edizioni del Galluzzo , 2016, XII + 300 p. ISBN: 978-88-8450-691-7

    Directory of Open Access Journals (Sweden)

    Marta Marfany Simó

    2016-12-01

    Full Text Available Review to Delle Donne, Fulvio & Torró, Jaume (eds. L’immagine di Alfonso il Magnanimo tra letteratura e storia, tra Corona d’Aragona e Italia - La imatge d’Algons el Magnànim en la literatura i la Historiografia entre la Corona d’Aragó i Itàlia, Firenze, SISMEL -Edizioni del Galluzzo , 2016, XII + 300 p. ISBN: 978-88-8450-691-7

  18. Innovación y ruptura en la métrica de la poesía en al-Maqāmāt al-Luzūmiyya de al-Saraqusṭī (s. VI/XII

    Directory of Open Access Journals (Sweden)

    Ferrando, Ignacio

    2016-06-01

    Full Text Available Al-Maqāmāt al-Luzūmiyya, a collection of 50 picaresque-like stories couched in rhymed prose by Abū l-Ṭāhir al-Saraqusṭī in al-Andalus in the VI/XIIth century, were considered by Western scholars, up until the eighties of XXth century, as highly rhetorical pieces with a negligible and irrelevant content. However, some contemporary scholars argued that they contain some degree of social and political criticism, as they constitute a fictional domain in which subversion and irony play a fundamental role. In this paper, we cast some light on the particular use of metrical patterns in Al-Maqāmāt al-Luzūmiyya, which should be considered another subversion field: a poetical rhythm that avoids the most usual Arabic metrical patterns, contributing to provide the maqāma a flavor of the countergenre.Al-Maqāmāt al-Luzūmiyya, la colección de 50 relatos de corte picaresco escritos en una exigente prosa rimada por Abū l-Ṭāhir al-Saraqusṭī en al-Andalus en el siglo VI/XII, han sido consideradas por los críticos occidentales como piezas de alta retórica y de virtuosismo lingüístico en las que el contenido es prácticamente irrelevante. Sin embargo, a partir de los años 80 del siglo pasado, algunos investigadores han tratado de incidir en el hecho de que esta obra contiene cierto grado de crítica social y política, puesto que constituye un espacio ficticio en el que la subversión y la ironía desempeñan un papel fundamental. En este trabajo vamos a tratar de arrojar luz sobre el uso particular de los esquemas métricos por parte de al-Saraqusṭī, tratando de mostrar que los metros constituyen otro más de los ámbitos de subversión tan caros al autor. De hecho, el uso de ritmos “invertidos” o contrarios a los más habituales de la poesía clásica contribuye a darle a la maqāma ese aire de anti género que la puebla.

  19. Synthesis of human pancreatic growth hormone-releasing factor and two omission analogs by segment-coupling method in aqueous solution

    Energy Technology Data Exchange (ETDEWEB)

    Blake, J.; Westphal, M.; Li, C.H. (Laboratory of Molecular Endocrinology, University of California, San Francisco, USA)

    1984-01-01

    The human growth hormone-releasing factor (GRF) peptides (GlyS/sup 15/)-GRF-(1-15) (IV), trifluoroacetyl-GRF-(20-44) (VI), trifluoroacetyl-GRF-(18-44) (VIII), and trifluoroacetyl-GRF-(16-44) (X) were synthesized by the solidphase method. Each of the peptides was reacted with citraconic anhydride and the trifluoroacetyl group was removed by reaction with 10% hydrazine in water. The citraconylated GRF-(1-15) peptide was coupled to the (20-44), (18-44) or (16-44) peptides by reaction with silver nitrate/N-hydroxysuccinimide to give GRF-(1-15)-(20-44) (XII), GRF-(1-15)-(18-44) (XIII), or GRF-(1-44), respectively. GRF-(1-44) was shown to stimulate the release of rat growth hormone from rat pituitary cells with an ED/sub 50/=8.8 x 10/sup -11/M. Peptides XII and XIII were inactive, either as agonists or as antagonists of the action of GRF-(1-44).

  20. Al-Ḏajīra al-saniyya: una fuente relevante para el siglo XII en la Península Ibérica

    Directory of Open Access Journals (Sweden)

    Ramírez-del-Río, José

    2012-06-01

    Full Text Available The work al-Dhakhīra al-saniyya fī ta’rīkh al-dawla al-marīniyya records the history of the Marīnid dynasty, including a number of references to other Islamic regions like Egypt, Syria and al-Andalus. The authorship of this chronicle has not yet been solved. The aim of this paper is to provide the most relevant information on the issue. Alongside with other type of information concerning al-Andalus, this paper focuses on that which concerns the territory conquered by the Kingdom of Castile throughout the 13th century, and which so far has been mostly disregarded. It undoubtedly contributes to improve our knowledge of the period, especially as regards both the destiny of the conquered Muslim populations and the chronology of the conquest. We will also focus here on the political leaders of al-Andalus and Maghreb, their reactions towards the Christian conquests, ranging from utter resistance to conversion, and the importance this group attached to fighting the Christians, as a key factor of the political legitimacy of the Banū Marīn to guide the Islamic community, a point that greatly concerns the author of the present chronicle.La obra al-Ḏajīra al-saniyya fī ta’rīj aldawla al-marīniyya, que aborda la historia de los Banū Marīn, incluye una serie de noticias referentes a otras tierras de la Dār al-Islam, como Egipto, Siria o al-Andalus. La autoría de la misma no ha sido determinada, por lo que señalaremos las noticias más destacadas sobre este asunto. De la información que ofrece esta obra acerca de al-Andalus, este artículo se centra en el análisis de los fragmentos relativos a los territorios conquistados por Castilla durante el s. XIII, que no había sido aprovechada hasta el momento, y que contribuye a ampliar nuestro conocimiento acerca de este período histórico, muy especialmente por lo que respecta a la suerte que corrieron las poblaciones musulmanas y a la cronología de la conquista. Abordamos las actitudes

  1. Genetic programming theory and practice XII

    CERN Document Server

    Riolo, Rick; Kotanchek, Mark

    2015-01-01

    These contributions, written by the foremost international researchers and practitioners of Genetic Programming (GP), explore the synergy between theoretical and empirical results on real-world problems, producing a comprehensive view of the state of the art in GP. Topics in this volume include: gene expression regulation, novel genetic models for glaucoma, inheritable epigenetics, combinators in genetic programming, sequential symbolic regression, system dynamics, sliding window symbolic regression, large feature problems, alignment in the error space, HUMIE winners, Boolean multiplexer funct

  2. Defects and diffusion in semiconductors XII

    CERN Document Server

    Fisher, David J

    2010-01-01

    This twelfth volume in the series covering the latest results in the field includes abstracts of papers which have appeared since the publication of Annual Retrospective XI (Volume 282). As well as the 565 semiconductor-related abstracts, the issue includes - in line with the policy of including original papers on all of the major material groups: ""Study of Conduction Mechanism in Amorphous Se85-xTe15Bix Thin Films"" (A.Sharma and P.B.Barman), ""Structure and Optical Properties of Magnetron-Sputtered SiOx Layers with Silicon Nanoparticles"" (L.Khomenkova, N.Korsunska, T.Stara, Y.Goldstein, J.

  3. Planck 2013 results. XII. Diffuse component separation

    CERN Document Server

    Ade, P A R; Armitage-Caplan, C; Arnaud, M; Ashdown, M; Atrio-Barandela, F; Aumont, J; Baccigalupi, C; Banday, A J; Barreiro, R B; Bartlett, J G; Battaner, E; Benabed, K; Benoît, A; Benoit-Lévy, A; Bernard, J -P; Bersanelli, M; Bielewicz, P; Bobin, J; Bock, J J; Bonaldi, A; Bonavera, L; Bond, J R; Borrill, J; Bouchet, F R; Boulanger, F; Bridges, M; Bucher, M; Burigana, C; Butler, R C; Cardoso, J -F; Catalano, A; Challinor, A; Chamballu, A; Chary, R -R; Chen, X; Chiang, L -Y; Chiang, H C; Christensen, P R; Church, S; Clements, D L; Colombi, S; Colombo, L P L; Couchot, F; Coulais, A; Crill, B P; Cruz, M; Curto, A; Cuttaia, F; Danese, L; Davies, R D; Davis, R J; de Bernardis, P; de Rosa, A; de Zotti, G; Delabrouille, J; Delouis, J -M; Désert, F -X; Dickinson, C; Diego, J M; Dole, H; Donzelli, S; Doré, O; Douspis, M; Dunkley, J; Dupac, X; Efstathiou, G; Enßlin, T A; Eriksen, H K; Falgarone, E; Finelli, F; Forni, O; Frailis, M; Fraisse, A A; Franceschi, E; Galeotta, S; Ganga, K; Giard, M; Giardino, G; Giraud-Héraud, Y; González-Nuevo, J; Górski, K M; Gratton, S; Gregorio, A; Gruppuso, A; Hansen, F K; Hanson, D; Harrison, D; Helou, G; Henrot-Versillé, S; Hernández-Monteagudo, C; Herranz, D; Hildebrandt, S R; Hivon, E; Hobson, M; Holmes, W A; Hornstrup, A; Hovest, W; Huey, G; Huffenberger, K M; Jaffe, T R; Jaffe, A H; Jewell, J; Jones, W C; Juvela, M; Keihänen, E; Keskitalo, R; Kisner, T S; Kneissl, R; Knoche, J; Knox, L; Kunz, M; Kurki-Suonio, H; Lagache, G; Lähteenmäki, A; Lamarre, J -M; Lasenby, A; Laureijs, R J; Lawrence, C R; Jeune, M Le; Leach, S; Leahy, J P; Leonardi, R; Lesgourgues, J; Liguori, M; Lilje, P B; Linden-Vørnle, M; López-Caniego, M; Lubin, P M; Macías-Pérez, J F; Maffei, B; Maino, D; Mandolesi, N; Marcos-Caballero, A; Maris, M; Marshall, D J; Martin, P G; Martínez-González, E; Masi, S; Matarrese, S; Matthai, F; Mazzotta, P; Meinhold, P R; Melchiorri, A; Mendes, L; Mennella, A; Migliaccio, M; Mikkelsen, K; Mitra, S; Miville-Deschênes, M -A; Moneti, A; Montier, L; Morgante, G; Mortlock, D; Moss, A; Munshi, D; Naselsky, P; Nati, F; Natoli, P; Netterfield, C B; Nørgaard-Nielsen, H U; Noviello, F; Novikov, D; Novikov, I; O'Dwyer, I J; Osborne, S; Oxborrow, C A; Paci, F; Pagano, L; Pajot, F; Paladini, R; Paoletti, D; Partridge, B; Pasian, F; Patanchon, G; Pearson, T J; Perdereau, O; Perotto, L; Perrotta, F; Pettorino, V; Piacentini, F; Piat, M; Pierpaoli, E; Pietrobon, D; Plaszczynski, S; Platania, P; Pointecouteau, E; Polenta, G; Ponthieu, N; Popa, L; Poutanen, T; Pratt, G W; Prézeau, G; Prunet, S; Puget, J -L; Rachen, J P; Reach, W T; Rebolo, R; Reinecke, M; Remazeilles, M; Renault, C; Renzi, A; Ricciardi, S; Riller, T; Ristorcelli, I; Rocha, G; Rosset, C; Roudier, G; Rowan-Robinson, M; Rubiño-Martín, J A; Rusholme, B; Salerno, E; Sandri, M; Santos, D; Savini, G; Schiavon, F; Scott, D; Seiffert, M D; Shellard, E P S; Spencer, L D; Starck, J -L; Stompor, R; Sudiwala, R; Sunyaev, R; Sureau, F; Sutton, D; Suur-Uski, A -S; Sygnet, J -F; Tauber, J A; Tavagnacco, D; Terenzi, L; Toffolatti, L; Tomasi, M; Tristram, M; Tucci, M; Tuovinen, J; Türler, M; Umana, G; Valenziano, L; Valiviita, J; Van Tent, B; Varis, J; Viel, M; Vielva, P; Villa, F; Vittorio, N; Wade, L A; Wandelt, B D; Wehus, I K; Wilkinson, A; Xia, J -Q; Yvon, D; Zacchei, A; Zonca, A

    2014-01-01

    Planck has produced detailed all-sky observations over nine frequency bands between 30 and 857 GHz. These observations allow robust reconstruction of the primordial cosmic microwave background (CMB) temperature fluctuations over nearly the full sky, as well as new constraints on Galactic foregrounds. This paper describes the component separation framework adopted by Planck. We test four foreground-cleaned CMB maps derived using qualitatively different component separation algorithms. The quality of our reconstructions is evaluated through detailed simulations and internal comparisons, and shown through various tests to be internally consistent and robust for CMB power spectrum and cosmological parameter estimation up to l = 2000. The parameter constraints on LambdaCDM cosmologies derived from these maps are consistent with those presented in the cross-spectrum based Planck likelihood analysis. We choose two of the CMB maps for specific scientific goals. We also present maps and frequency spectra of the Galact...

  4. Progress in ultrafast intense laser science XII

    CERN Document Server

    Roso, Luis; Li, Ruxin; Mathur, Deepak; Normand, Didier

    2015-01-01

    This  volume covers a broad range of topics focusing on atoms, molecules, and clusters interacting in intense laser field, laser induced filamentation, and laser plasma interaction and application. The PUILS series delivers up-to-date reviews of progress in Ultrafast Intense Laser Science, a newly emerging interdisciplinary research field spanning atomic and molecular physics, molecular science, and optical science, which has been stimulated by the recent developments in ultrafast laser technologies. Each volume compiles peer-reviewed articles authored by researchers at the forefront of each their own subfields of UILS. Every chapter opens with an overview of the topics to be discussed, so that researchers unfamiliar to the subfield, as well as graduate students, can grasp the importance and attractions of the research topic at hand; these are followed by reports of cutting-edge discoveries. .

  5. 14. XII korraldas Viviann Napa galerii...

    Index Scriptorium Estoniae

    2005-01-01

    Galerii korraldasTallinna Psühhiaatriahaigla heaks heategevusõhtu. Monotüüpia trükitehnikat tutvustas Marju Bormeister. Tema õlimaalide, akvarellide ja monotüüpiate müügitulu läks haigla heaks

  6. Remesas y desarrollo (Casablanca 15.XII.2006)

    OpenAIRE

    Cebrián de Miguel, Juan Antonio; Bodega Fernández, María Isabel; Martín Lou, María Asunción

    2007-01-01

    El 15 de diciembre de 2006 tuvo lugar en Casablanca el seminario "Remesas y Desarrollo", organizado por Remesas.org, el Comité Averroes y el Insitut Europeu de la Mediterrània. El seminario contaba con el patrocinio del Attijariwafa Bank, el Grupo Santander, la Asociación Nacional de Agencias de Envío de Dinero y el periódico L’Economiste. En esta nota presentamos un resumen de las discusiones del seminario y algunas de las tablas del informe resumen de la Dirección General de Economía y F...

  7. Division XII: Commission 6: Astronomical Telegrams

    Science.gov (United States)

    Samus, N. N.; Yamaoka, H.; Gilmore, A. C.; Aksnes, K.; Green, D. W. E.; Marsden, B. G.; Nakano, S.; Lara, Martin; Pitjeva, Elena V.; Sphar, T.; Ticha, J.; Williams, G.

    2015-08-01

    IAU Commission 6 ``Astronomical Telegrams'' had a single business meeting during the Beijing General Assembly of the IAU. It took place on Friday, August 24, 2012. The meeting was attended by five C6 members (N. N. Samus; D. W. E. Green; S. Nakano; J. Ticha; and H. Yamaoka). Also present was Prof. F. Genova as a representative of the IAU Division B. She told the audience about the current restructuring of IAU Commissions and Divisions and consequences for the future of C6.

  8. Kuni 11. XII oli Tallinna Linnagaleriis...

    Index Scriptorium Estoniae

    2005-01-01

    Valie Export Society (Kadi Estland, Mari Laanemets, Killu Sukmit) väljapanek "Streik ei ole horoskoop!" - dokumentatsioon, kus üksteisele saadetud e-kirjades avatakse naiskunstnike rühmituse eesmärk ja praegune olukord, peatutakse Eesti kunstielu võimuküsimustel

  9. Planck 2013 results. XII. Diffuse component separation

    Science.gov (United States)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.; Arnaud, M.; Ashdown, M.; Atrio-Barandela, F.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bobin, J.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bridges, M.; Bucher, M.; Burigana, C.; Butler, R. C.; Cardoso, J.-F.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chary, R.-R.; Chen, X.; Chiang, H. C.; Chiang, L.-Y.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Couchot, F.; Coulais, A.; Crill, B. P.; Cruz, M.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dobler, G.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Dunkley, J.; Dupac, X.; Efstathiou, G.; Enßlin, T. A.; Eriksen, H. K.; Falgarone, E.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Galeotta, S.; Ganga, K.; Giard, M.; Giardino, G.; Giraud-Héraud, Y.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Helou, G.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huey, G.; Huffenberger, K. M.; Jaffe, A. H.; Jaffe, T. R.; Jewell, J.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Knox, L.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Lasenby, A.; Laureijs, R. J.; Lawrence, C. R.; Le Jeune, M.; Leach, S.; Leahy, J. P.; Leonardi, R.; Lesgourgues, J.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maffei, B.; Maino, D.; Mandolesi, N.; Marcos-Caballero, A.; Maris, M.; Marshall, D. J.; Martin, P. G.; Martínez-González, E.; Masi, S.; Massardi, M.; Matarrese, S.; Matthai, F.; Mazzotta, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mikkelsen, K.; Mitra, S.; Miville-Deschênes, M.-A.; Molinari, D.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; O'Dwyer, I. J.; Osborne, S.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paladini, R.; Paoletti, D.; Partridge, B.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Platania, P.; Pointecouteau, E.; Polenta, G.; Ponthieu, N.; Popa, L.; Poutanen, T.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ricciardi, S.; Riller, T.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Roudier, G.; Rowan-Robinson, M.; Rubiño-Martín, J. A.; Rusholme, B.; Salerno, E.; Sandri, M.; Santos, D.; Savini, G.; Schiavon, F.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Starck, J.-L.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sureau, F.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Tavagnacco, D.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Türler, M.; Umana, G.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Varis, J.; Viel, M.; Vielva, P.; Villa, F.; Vittorio, N.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Wilkinson, A.; Xia, J.-Q.; Yvon, D.; Zacchei, A.; Zonca, A.

    2014-11-01

    Planck has produced detailed all-sky observations over nine frequency bands between 30 and 857 GHz. These observations allow robust reconstruction of the primordial cosmic microwave background (CMB) temperature fluctuations over nearly the full sky, as well as new constraints on Galactic foregrounds, including thermal dust and line emission from molecular carbon monoxide (CO). This paper describes the component separation framework adopted by Planck for many cosmological analyses, including CMB power spectrum determination and likelihood construction on large angular scales, studies of primordial non-Gaussianity and statistical isotropy, the integrated Sachs-Wolfe effect, gravitational lensing, and searches for topological defects. We test four foreground-cleaned CMB maps derived using qualitatively different component separation algorithms. The quality of our reconstructions is evaluated through detailed simulations and internal comparisons, and shown through various tests to be internally consistent and robust for CMB power spectrum and cosmological parameter estimation up to ℓ = 2000. The parameter constraints on ΛCDM cosmologies derived from these maps are consistent with those presented in the cross-spectrum based Planck likelihood analysis. We choose two of the CMB maps for specific scientific goals. We also present maps and frequency spectra of the Galactic low-frequency, CO, and thermal dust emission. The component maps are found to provide a faithful representation of the sky, as evaluated by simulations, with the largest bias seen in the CO component at 3%. For the low-frequency component, the spectral index varies widely over the sky, ranging from about β = -4 to - 2. Considering both morphology and prior knowledge of the low frequencycomponents, the index map allows us to associate a steep spectral index (β -2.3 with strong free-free emission, and intermediate values with synchrotron emission.

  10. Studies in Sulphonamides-Part XII

    Directory of Open Access Journals (Sweden)

    H. C. Mutreja

    1980-01-01

    Full Text Available Four new 1, 3-diarylpropane-1, 3-diones, 1-(m/p-nitrophenyl-3-(p-ethylphenyl-and 1-(m/p-nitrophenyl-3-(p-ehoxyphenyl propane-1, 3-diones have been synthesised and coupled with a number of diazotised sulphonamide bases to yield the corresponding 1, 3-diaryl-2-(N-substituted p-sulphamylbenzeneazo propane-1, 3-diones. These azo-compounds have been screened in vitro for their antibacterial properties against S. aureus, E. coli and P. pyocyanea.

  11. Kuni 11. XII oli Tallinna Linnagaleriis...

    Index Scriptorium Estoniae

    2005-01-01

    Valie Export Society (Kadi Estland, Mari Laanemets, Killu Sukmit) väljapanek "Streik ei ole horoskoop!" - dokumentatsioon, kus üksteisele saadetud e-kirjades avatakse naiskunstnike rühmituse eesmärk ja praegune olukord, peatutakse Eesti kunstielu võimuküsimustel

  12. Planck 2013 results. XII. Diffuse component separation

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.

    2014-01-01

    presented in the cross-spectrum based Planck likelihood analysis. We choose two of the CMB maps for specific scientific goals. We also present maps and frequency spectra of the Galactic low-frequency, CO, and thermal dust emission. The component maps are found to provide a faithful representation of the sky...... foregrounds, including thermal dust and line emission from molecular carbon monoxide (CO). This paper describes the component separation framework adopted by Planck for many cosmological analyses, including CMB power spectrum determination and likelihood construction on large angular scales, studies...... of primordial non-Gaussianity and statistical isotropy, the integrated Sachs-Wolfe effect, gravitational lensing, and searches for topological defects. We test four foreground-cleaned CMB maps derived using qualitatively different component separation algorithms. The quality of our reconstructions is evaluated...

  13. Planck 2013 results. XII. Component separation

    DEFF Research Database (Denmark)

    Planck Collaboration,; Ade, P. A. R.; Aghanim, N.

    2013-01-01

    analysis. We choose two of the CMB maps for specific scientific goals. We also present maps and frequency spectra of the Galactic low-frequency, CO, and thermal dust emission. The component maps are found to provide a faithful representation of the sky, as evaluated by simulations. For the low...... foregrounds. This paper describes the component separation framework adopted by Planck. We test four foreground-cleaned CMB maps derived using qualitatively different component separation algorithms. The quality of our reconstructions is evaluated through detailed simulations and internal comparisons......, and shown through various tests to be internally consistent and robust for CMB power spectrum and cosmological parameter estimation up to l = 2000. The parameter constraints on LambdaCDM cosmologies derived from these maps are consistent with those presented in the cross-spectrum based Planck likelihood...

  14. Surface-mediated molecular events in material-induced blood-plasma coagulation

    Science.gov (United States)

    Chatterjee, Kaushik

    Coagulation and thrombosis persist as major impediments associated with the use of blood-contacting medical devices. We are investigating the molecular mechanism underlying material-induced blood-plasma coagulation focusing on the role of the surface as a step towards prospective development of improved hemocompatible biomaterials. A classic observation in hematology is that blood/blood-plasma in contact with clean glass surface clots faster than when in contact with many plastic surfaces. The traditional biochemical theory explaining the underlying molecular mechanism suggests that hydrophilic surfaces, like that of glass, are specific activators of the coagulation cascade because of the negatively-charged groups on the surface. Hydrophobic surfaces are poor procoagulants or essentially "benign" because they lack anionic groups. Further, these negatively-charged surfaces are believed to not only activate blood factor XII (FXII), the key protein in contact activation, but also play a cofactor role in the amplification and propagation reactions that ultimately lead to clot formation. In sharp contrast to the traditional theory, our investigations indicate a need for a paradigm shift in the proposed sequence of contact activation events to incorporate the role of protein adsorption at the material surfaces. These studies have lead to the central hypothesis for this work proposing that protein adsorption to hydrophobic surfaces attenuates the contact activation reactions so that poorly-adsorbent hydrophilic surfaces appear to be stronger procoagulants relative to hydrophobic surfaces. Our preliminary studies measuring the plasma coagulation response of activated FXII (FXIIa) on different model surfaces suggested that the material did not play a cofactor role in the processing of this enzyme dose through the coagulation pathway. Therefore, we focused our efforts on studying the mechanism of initial production of enzyme at the procoagulant surface. Calculations for the

  15. Resumen de tesis. El Mišle he-‘araḇ (Los dichos de los árabes) y la tradición sapiencial hebrea (Península Ibérica y Provenza, s. XII y XIII)

    OpenAIRE

    2014-01-01

    [ES]La obra Mišle he-`arab [Los dichos de los árabes] es una obra escrita en hebreo entre los siglos XII y XIII, dividida en cincuenta capítulos en prosa, con poemas intercalados y de contenido ético sapiencial. De ella se conservan diez manuscritos datados entre los siglos XIII y XVII, cinco de los cuales están completos. Fue además editada por fascículos, capítulo a capítulo, en diversos números no consecutivos de la revista ha Lebanon, mientras era publicada en París entre 1865 y 1869. La ...

  16. Wolfgang Hagemann e la storia del Fermano nell’età degli Svevi (secoli XII-XIII: a margine di un progetto per la valorizzazione della ricerca storica / Wolfgang Hagemann and the history of the area of Fermo during the Svevian age (12th-13th centuries: notes on a project for the enhancement of the historical research

    Directory of Open Access Journals (Sweden)

    Francesco Pirani

    2011-11-01

    Full Text Available Il testo rende conto del progetto di riedizione, in traduzione italiana, degli studi compiuti da Wolfgang Hagemann (Lipsia, 1911 – Roma, 1978 sulle relazioni intercorse fra gli imperatori Hohenstaufer e i maggiori centri comunali del Fermano (secoli XII-XIII. Tali ricerche furono condotte dallo studioso per oltre un trentennio, dai primi anni Cinquanta fino alla metà degli anni Settanta del Novecento, con l’obiettivo principale di cogliere ogni traccia della presenza imperiale nelle Marche e, in particolare, nel Fermano. L’enorme mole della documentazione consultata negli archivi comunali, in gran parte edita in appendice dei saggi in forma di regesto, consentì ad Hagemann di tracciare un quadro storico estremamente mosso e dinamico, che ancor oggi offre numerosi stimoli culturali sia per gli studiosi che per un pubblico più vasto. This paper explains the re-edition’s project (in italian translation of same historical studies by Wolfgang Hagemann (Leipzig, 1911 – Rom, 1978. The german historian accomplished his researches on the relationships between the Hohenstaufer’s emperor and the most important ‘comuni’ in the region of Fermo (XII-XIII Century for over thirty-year period, since the beginning of 50s till the middle 70s of the XX Century. His main aim was to catch every evidence of the imperial presence in the Marches, especially in the region of Fermo. He looked through the council archives a huge amount of documents and often edited them as a summary in the essays’s appendix. That allows him to draw a picture very rich and appealing. Therefore, his studies still offers an interesting input both for historians and for wide users.

  17. "Nuts and Bolts" of Laboratory Evaluation of Angioedema.

    Science.gov (United States)

    Farkas, Henriette; Veszeli, Nóra; Kajdácsi, Erika; Cervenak, László; Varga, Lilian

    2016-10-01

    Angioedema, as a distinct disease entity, often becomes a clinical challenge for physicians, because it may cause a life-threatening condition, whereas prompt and accurate laboratory diagnostics may not be available. Although the bedside diagnosis needs to be established based on clinical symptoms and signs, family history, and the therapeutic response, later, laboratory tests are available. Currently, only for five out of the nine different types of angioedema can be diagnosed by laboratory testing, and these occur only in a minority of the patient population. Hereditary angioedema with C1-inhibitor (C1-INH) deficiency type I can be diagnosed by the low C1-INH function and concentration, whereas in type II, C1-INH function is low, but its concentration is normal or even elevated. C1q concentration is normal in both forms. Acquired angioedema with C1-INH deficiency type I is characterized by the low C1-INH function and concentration; however, C1q concentration is also low, and autoantibodies against C1-INH cannot be detected. Complement profile of acquired angioedema with C1-INH deficiency type II is similar to that of type I, but in this form, autoantibodies against C1-INH are present. Hereditary angioedema due to a mutation of the coagulation factor XII can be diagnosed exclusively by mutation analysis of FXII gene. Diagnostic metrics are not available for idiopathic histaminergic acquired angioedema, idiopathic non-histaminergic acquired angioedema, acquired angioedema related to angiotensin-converting enzyme inhibitor, and hereditary angioedema of unknown origin; these angioedemas can be diagnosed by medical and family history, clinical symptoms, and therapeutic response and by excluding the forms previously described. Several potential biomarkers of angioedema are used to date only in research. In the future, they could be utilized into the clinical practice to improve the differential diagnosis, therapy, as well as the prognosis of angioedema.

  18. OC-03 - Modelisation of the procoagulant properties of cancer cells and their capacity to alter the antithrombotic efficiency of LMWHs and specific inhibitors of factor Xa.

    Science.gov (United States)

    Gerotziafas, G T; Rousseau, A; van Dreden, P; Mbemba, E; Gkalea, V; Khaterchi, A; Larsen, A; Elalamy, I

    2016-04-01

    The risk of venous thromboembolism varies according to the histological type of cancer. The failure of antithrombotic treatment is more frequent in cancer patients as compared to non-cancer ones. We aimed to elucidate the mechanism of activation of blood coagulation induced by cancer, the impact of chemo-resistance phenotype on the capacity of cancer cells to trigger thrombin generation and the alterations of the efficiency of LMWHs and the specific inhibitors of factor Xa (fondaparinux and apixaban) in the presence of cancer cells. Thrombin generation of human plasma was assessed in the presence of various cancer cell lines. The model of cancer-induced hypercoagulability was coupled to the research for the expression of procoagulant molecules by cancer cells. The pancreatic adenocarcinoma cells BXPC3 and the breast adenocarcinoma cells MCF7 were initially tested. The BXPC3 cells induce significantly higher thrombin generation as compared to the MCF7 cells. In the same line Marchetti et al. showed that malignant hematologic cells (NB4, HEL, and K562) and H69 small cell lung cells express different procoagulant potential on triggering thrombin generation of human plasma. The comparison of the procoagulant activity has been extended to cancer cell lines from various cancers (i.e. colon, ovarian and prostatic cancer) as well as to different cell lines of the same type of cancer. The differences of the cancer cell lines to trigger thrombin generation are mainly due to the expression of TF. The acquisition of chemoresistant phenotype by cancer cells is correlated with increased TF expression and enhancement of theit procoagulant activity. The ability of cancer cells to activate FXII is an alternative pathway of significant importance for some cancer cell lines (i.e. MCF7). Clinically relevant concentrations of LMWH and specific direct and indirect inhibitors of FXa (apixaban and fondaparinux) inhibit thrombin generation induced by cancer cells. The synergy between the

  19. Tissue factor expression on the surface of monocytes from a patient with hereditary angioedema.

    Science.gov (United States)

    Iwamoto, Kazumasa; Morioke, Satoshi; Yanase, Yuhki; Uchida, Kazue; Hide, Michihiro

    2014-10-01

    Hereditary angioedema (HAE) presents as severe angioedema, which is mostly due to the C1 inhibitor (C1-INH) gene mutations. Environmental factors, minor trauma and oral contraceptives have been reported to induce angioedema attack, but the trigger may often be uncertain. Activated factor XII controlled by C1-INH facilitates bradykinin generation and also regulates coagulation cascade, but the relationship between edema formation and coagulation is still unclear. We have described a 35-year-old female patient with HAE, presenting with frequent angioedema attacks in the absence of an apparent triggering factor. She showed higher levels of FDP and D-dimer during angioedema than those in remission. In addition, tissue factor (TF), an initiator of the extrinsic coagulation cascade, was expressed on the surface of monocytes. It was significantly higher than that of monocytes from healthy controls and tends to further increase during attacks. The expression of TF on monocytes may play a role in the induction of angioedema attacks in HAE by activating the coagulation pathway in association with reduced functions of C1-INH.

  20. Corruption Factors

    OpenAIRE

    Polterovich, Victor

    1998-01-01

    Among the factors that give rise to corruption, it is suggested that three groups be distinguished: fundamental factors rooted in the imperfection of economic institutions and economic policy, organizational factors ("weakness of the government"), and societal factors that depend on the prehistory and are connected with the mass culture and norms of bureaucratic behavior. A model in which corruption equilibrium is supported by non-optimum tax policy or by slow technical progress is compared w...

  1. El factoring

    Directory of Open Access Journals (Sweden)

    Alberto Rosenthal

    1988-04-01

    Full Text Available RESUMEN El artículo  presenta, una conceptualización general de lo que es el factoring, el origen del mismo, su evolución y hace una clasificación de los distintos tipos de factoring.

  2. Robust factorization

    DEFF Research Database (Denmark)

    Aanæs, Henrik; Fisker, Rune; Åström, Kalle;

    2002-01-01

    Factorization algorithms for recovering structure and motion from an image stream have many advantages, but they usually require a set of well-tracked features. Such a set is in generally not available in practical applications. There is thus a need for making factorization algorithms deal...... effectively with errors in the tracked features. We propose a new and computationally efficient algorithm for applying an arbitrary error function in the factorization scheme. This algorithm enables the use of robust statistical techniques and arbitrary noise models for the individual features....... These techniques and models enable the factorization scheme to deal effectively with mismatched features, missing features, and noise on the individual features. The proposed approach further includes a new method for Euclidean reconstruction that significantly improves convergence of the factorization algorithms...

  3. El factoring

    Directory of Open Access Journals (Sweden)

    Alberto Rosenthal

    2015-04-01

    Full Text Available RESUMEN Se presenta la segunda parte del artículo aparecido en  el número 6 de la revista EAN. Su contenido es complementario a lo expuesto en dicho número, en está aparecen las ventajas del factoring, conveniencias, limitaciones así como la forma  de efectuar un factor en Colombia,  su necesidad, incidencia económica, etc.

  4. Atomic data from the iron project. 3: Rate coefficients for electron impact excitation of boron-like ions: Ne VI, Mg VIII, Al IX, Si X, S XII, Ar XIV, Ca XVI and Fe XXII

    Science.gov (United States)

    Zhang, Hong Lin; Graziani, Mark; Pradhan, Anil K.

    1994-01-01

    Collison strengths and maxwellian averaged rate coefficients have been calculated for the 105 transitions among all 15 fine structure levels of the 8 LS terms 2s(sup 2) 2 P(P-2(sup 0 sub 1/, 3/2)), 2s2p(sup 2)(P-4(sub 1/2,3/2,5/2), D-2(sub 3/2, 5/2), S-2(sub 1/2), P-2(sub 1/2, 3/2)), 2p(sup 3)(S-4(sup 0)(sub 3/2), D-2(sup 0 sub 3/2, 5/2), P-2(sup 0 sub 1/2, 3/2)) in highly- charged B-like Ne, Mg, Al, Si, S, Ar, Ca and Fe. Rate coefficients have been tabulated at a wide range of temperatures, depending on the ion charge and abundance in plasma sources. Earlier work for O IV has also been extended to include the high temperature range. A brief discussion of the calculations, sample results, and comparison with earlier works is also given. While much of the new data should be applicable to UV spectral diagnostics, the new rates for the important ground state fine structure transition P-2(sup 0 sub 1/2)-P-2(sup 0 sub 3/2) should result in significant revision of the IR cooling rates in plasmas where B-like ions are prominent constituents, since the new rate coefficients are generally higher by several factors compared with the older data.

  5. Comparison of Ways to Use Weighted Factors for Developing Vehicle Schedules in a Mass Transit System.

    Science.gov (United States)

    1983-03-01

    A4 . . . . .......... 47 XI. T rip Depth Affects ....... ......... 8 XII . Ca-abase 2 Initial Rssul-s . . . . ........ 50 XIII. Database 2- Varying Al...230 trips. Tabl = XII TABLE III Database 2 Initial Results Parametirs: Al= I A2= 1 A3= 1 A4= 1 IDHT= 20 MWT= 30 M JM-I IMD I WT I DHT I NBI L/B I VSI I...from the MST database. Tabla XIII shows the effects Cf varying Al and A2. For ma.hcd 4, -here was a 50 .0 .. TABLE XIII Database 2 - Varying Al and &2

  6. Ongoing contact activation in patients with hereditary angioedema.

    Directory of Open Access Journals (Sweden)

    Joke Konings

    Full Text Available Hereditary angioedema (HAE is predominantly caused by a deficiency in C1 esterase inhibitor (C1INH (HAE-C1INH. C1INH inhibits activated factor XII (FXIIa, activated factor XI (FXIa, and kallikrein. In HAE-C1INH patients the thrombotic risk is not increased even though activation of the contact system is poorly regulated. Therefore, we hypothesized that contact activation preferentially leads to kallikrein formation and less to activation of the coagulation cascade in HAE-C1INH patients. We measured the levels of C1INH in complex with activated contact factors in plasma samples of HAE-C1INH patients (N=30, 17 during remission and 13 during acute attack and healthy controls (N=10. We did not detect differences in enzyme-inhibitor complexes between samples of controls, patients during remission and patients during an acute attack. Reconstitution with C1INH did not change this result. Next, we determined the potential to form enzyme-inhibitory complexes after complete in vitro activation of the plasma samples with a FXII trigger. In all samples, enzyme-C1INH levels increased after activation even in patients during an acute attack. However, the levels of FXIIa-C1INH, FXIa-C1INH and kallikrein-C1INH were at least 52% lower in samples taken during remission and 70% lower in samples taken during attack compared to samples from controls (p<0.05. Addition of C1INH after activation led to an increase in levels of FXIIa-C1INH and FXIa-C1INH (p<0.05, which were still lower than in controls (p<0.05, while the levels of kallikrein-C1INH did not change. These results are consistent with constitutive activation and attenuated depletion of the contact system and show that the ongoing activation of the contact system, which is present in HAE-C1INH patients both during remission and during acute attacks, is not associated with preferential generation of kallikrein over FXIa.

  7. Behavioral factors.

    Science.gov (United States)

    Zero, D T; Lussi, A

    2006-01-01

    During and after an erosive challenge, behavioral factors play a role in modifying the extent of erosive tooth wear. The manner that dietary acids are introduced into the mouth (gulping, sipping, use of a straw) will affect how long the teeth are in contact with the erosive challenge. The frequency and duration of exposure to an erosive agent is of paramount importance. Night-time exposure (e.g. baby bottle-feeding) to erosive agents may be particularly destructive because of the absence of salivary flow. Health-conscious individuals tend to ingest acidic drinks and juices more frequently and tend to have higher than average oral hygiene. While good oral hygiene is of proven value in the prevention of periodontal disease and dental caries, frequent toothbrushing with abrasive oral hygiene products may enhance erosive tooth wear. Unhealthy lifestyles such as consumption of designer drugs, alcopops and alcohol abuse are other important behavioral factors.

  8. Factor analysis

    CERN Document Server

    Gorsuch, Richard L

    2013-01-01

    Comprehensive and comprehensible, this classic covers the basic and advanced topics essential for using factor analysis as a scientific tool in psychology, education, sociology, and related areas. Emphasizing the usefulness of the techniques, it presents sufficient mathematical background for understanding and sufficient discussion of applications for effective use. This includes not only theory but also the empirical evaluations of the importance of mathematical distinctions for applied scientific analysis.

  9. Plasma levels of plasminogen activator inhibitor type 1, factor VIII, prothrombin activation fragment 1+2, anticardiolipin, and antiprothrombin antibodies are risk factors for thrombosis in hemodialysis patients.

    Science.gov (United States)

    Molino, Daniela; De Santo, Natale G; Marotta, Rosa; Anastasio, Pietro; Mosavat, Mahrokh; De Lucia, Domenico

    2004-09-01

    , there was a reduction of factor XII during the treatment. It is possible to assume in the TC group and, to a lesser extent, also in the NTC group that endothelial cells liberate PAI-1 in the vascular lumen, which causes hypofibrinolysis. In addition, an excess of factor VIII is activated by endothelial dysfunction with subsequent activation of the coagulation cascade as shown by increased F1+2 and fibrinogen. ACA-IgM, in turn, is capable of interfering with the system of protein C, a potent anticoagulant factor that inactivates cofactors Va and VIIIa. They also induce the expression of procoagulant factors on the surface of the endothelial cells. In conclusion, the hypercoagulable state caused by alterations of coagulation and fibrinolytic factors is a cause of vascular access dysfunction and thrombosis of other vessels.

  10. DISTRIBUTION OF RIVER RUNOFF AND ITS CLIMATE FACTORS IN AVERAGE AND EXTREME YEARS

    Directory of Open Access Journals (Sweden)

    Vladimir Konovalov

    2011-01-01

    Full Text Available Schematic maps of spatial distribution of seasonal precipitation amounts and average air temperatures were obtained for the areas studied in years with normal and extreme values of annual river runoff. Data on precipitation for January–December (I–XII and on average air temperatures for June–September (VI–IX during 1961–1990 collected at 93 meteorological stations located along 30.20°–44.08°N and 67.20°–82.98°E, altitude 122–4 169 m above sea level, were used in the maps’ compilation. For each point-element (i.e. a meteorological station with proper data, the ordinates of an integral empirical function of distribution of probabilities P were calculated from these data for a 30-year sample period and for each year were received average values and standard deviations of P. In characteristic years were revealed, significant differences of spatial distribution of climatic factors and runoff. It was found out also that the spatial distribution of the total volume of glaciers melting is less variable in the years with extreme water yields compared to the average years. This peculiarity is very beneficial for hydropower and agriculture sectors because it provides additional natural ability to stabilize water balance of reservoirs. Piecewise multi-factor linear equations were obtained to calculate the statistical probability of glaciers’ total melting in low and high flow years as a function of geographical coordinates and the average altitude of firn boundary.

  11. La Mancha en el siglo XII: sociedades, espacios, culturas

    Directory of Open Access Journals (Sweden)

    Francisco RUIZ GÓMEZ

    2009-12-01

    Full Text Available RESUMEN: El presente trabajo es una reflexión sobre las circunstancias históricas del proceso de conquista cristiana de La Mancha. Los acontecimientos analizados se enmarcan entre dos hechos de enorme trascendencia: la conquista de Toledo en 1085 y la victoria cristiana de Las Navas de Tolosa en 1212, que supuso el inicio de la caída del imperio almohade. El punto de observación son los campos de La Mancha, un amplio sector de la frontera castellana que se convirtió entonces en un escenario, en el que participaban reyes, caballeros cristianos y musulmanes, y órdenes militares, cuyo papel en la vertebración de un nuevo paisaje y una nueva sociedad en La Mancha resultó fundamental.ABSTRACT: This paper is a remark about the historical circumstances of the process of Christian conquest of La Mancha. The events are framed between two relevant facts: the conquest of the city of Toledo in 1085 and the Christian victory in Las Navas de Tolosa in 1212, which involved the beginning of the fall of the Almohad Empire. The observatory is the countryside of La Mancha, a wide area of the Castilian frontier that was then turned into an arena in which kings, Christian and Muslim knights and overall military orders took part. The role of the military orders in the shaping of a new landscape and society in La Mancha was essential.

  12. Wood Anatomy of the Neotropical Sapotaceae. XII. Neoxythece.

    Science.gov (United States)

    1979-01-01

    dura. The longest average of 1.14 mn was from an unassigned specimen (Krukoff 1065). Tyloses commonly sclerotic and usually very abundant in the...3229) ,show ing pa1renchyma deta Ii potr ;in( parencuhyma and sclerotic tyloses Xl 10. arrangement X 30. Figure 7.--Elaeoltima Slabrescens Figure 8

  13. Division X, XII / Commission 40, 41 / Working Group Radio Astronomy

    NARCIS (Netherlands)

    Kellermann, Kenneth; Orchiston, Wayne; Davies, Rod; Gurvits, Leonid; Ishiguro, Masato; Lequeux, James; Swarup, Govind; Wall, Jasper; Wielebinski, Richard; van Woerden, Hugo

    2012-01-01

    The IAU Working Group on Historical Radio Astronomy (WGHRA) was formed at the 2003 General Assembly of the IAU as a Joint Working Group of Commissions 40 (Radio Astronomy) and 41 (History of Astronomy), in order to: a) assemble a master list of surviving historically-significant radio telescopes and

  14. 13. XII kell 16 avatakse rahvusraamatukogu VI korruse galeriis...

    Index Scriptorium Estoniae

    2005-01-01

    Näitus "Euroopa XVIII sajandi sügavtrükigraafika Eesti rahvusraamatukogu kollektsioonist". Autoritest nimetatud Bernard Picart (1673-1733), Daniel Nikolaus Chodowiecki (1726-1801), Domenico Bernardo Zilotti (u 1730-1780). Esitletakse näituse kataloogi. Kunstiteadlane Jüri Hain peab ajastu graafika ja näituse teemal loengu

  15. Planck 2015 results. XII. Full Focal Plane simulations

    CERN Document Server

    Ade, P A R; Arnaud, M; Ashdown, M; Aumont, J; Baccigalupi, C; Banday, A J; Barreiro, R B; Bartlett, J G; Bartolo, N; Battaner, E; Benabed, K; Beno\\^\\it, A; Benoit-Lévy, A; Bernard, J -P; Bersanelli, M; Bielewicz, P; Bock, J J; Bonaldi, A; Bonavera, L; Bond, J R; Borrill, J; Bouchet, F R; Boulanger, F; Bucher, M; Burigana, C; Butler, R C; Calabrese, E; Cardoso, J -F; Castex, G; Catalano, A; Challinor, A; Chamballu, A; Chiang, H C; Christensen, P R; Clements, D L; Colombi, S; Colombo, L P L; Combet, C; Couchot, F; Coulais, A; Crill, B P; Curto, A; Cuttaia, F; Danese, L; Davies, R D; Davis, R J; de Bernardis, P; de Rosa, A; de Zotti, G; Delabrouille, J; Delouis, J -M; Désert, F -X; Dickinson, C; Diego, J M; Dolag, K; Dole, H; Donzelli, S; Doré, O; Douspis, M; Ducout, A; Dupac, X; Efstathiou, G; Elsner, F; Enßlin, T A; Eriksen, H K; Fergusson, J; Finelli, F; Forni, O; Frailis, M; Fraisse, A A; Franceschi, E; Frejsel, A; Galeotta, S; Galli, S; Ganga, K; Ghosh, T; Giard, M; Giraud-Héraud, Y; Gjerløw, E; González-Nuevo, J; Górski, K M; Gratton, S; Gregorio, A; Gruppuso, A; Gudmundsson, J E; Hansen, F K; Hanson, D; Harrison, D L; Henrot-Versillé, S; Hernández-Monteagudo, C; Herranz, D; Hildebrandt, S R; Hivon, E; Hobson, M; Holmes, W A; Hornstrup, A; Hovest, W; Huffenberger, K M; Hurier, G; Jaffe, A H; Jaffe, T R; Jones, W C; Juvela, M; Karakci, A; Keihänen, E; Keskitalo, R; Kiiveri, K; Kisner, T S; Kneissl, R; Knoche, J; Kunz, M; Kurki-Suonio, H; Lagache, G; Lamarre, J -M; Lasenby, A; Lattanzi, M; Lawrence, C R; Leonardi, R; Lesgourgues, J; Levrier, F; Liguori, M; Lilje, P B; Linden-Vørnle, M; Lindholm, V; López-Caniego, M; Lubin, P M; Mac\\'\\ias-Pérez, J F; Maggio, G; Maino, D; Mandolesi, N; Mangilli, A; Maris, M; Martin, P G; Mart\\'\\inez-González, E; Masi, S; Matarrese, S; McGehee, P; Meinhold, P R; Melchiorri, A; Melin, J -B; Mendes, L; Mennella, A; Migliaccio, M; Mitra, S; Miville-Deschênes, M -A; Moneti, A; Montier, L; Morgante, G; Mortlock, D; Moss, A; Munshi, D; Murphy, J A; Naselsky, P; Nati, F; Natoli, P; Netterfield, C B; Nørgaard-Nielsen, H U; Noviello, F; Novikov, D; Novikov, I; Oxborrow, C A; Paci, F; Pagano, L; Pajot, F; Paoletti, D; Pasian, F; Patanchon, G; Pearson, T J; Perdereau, O; Perotto, L; Perrotta, F; Pettorino, V; Piacentini, F; Piat, M; Pierpaoli, E; Pietrobon, D; Plaszczynski, S; Pointecouteau, E; Polenta, G; Pratt, G W; Prézeau, G; Prunet, S; Puget, J -L; Rachen, J P; Rebolo, R; Reinecke, M; Remazeilles, M; Renault, C; Renzi, A; Ristorcelli, I; Rocha, G; Roman, M; Rosset, C; Rossetti, M; Roudier, G; Rubiño-Martín, J A; Rusholme, B; Sandri, M; Santos, D; Savelainen, M; Scott, D; Seiffert, M D; Shellard, E P S; Spencer, L D; Stolyarov, V; Stompor, R; Sudiwala, R; Sutton, D; Suur-Uski, A -S; Sygnet, J -F; Tauber, J A; Terenzi, L; Toffolatti, L; Tomasi, M; Tristram, M; Tucci, M; Tuovinen, J; Valenziano, L; Valiviita, J; Van Tent, B; Vielva, P; Villa, F; Wade, L A; Wandelt, B D; Wehus, I K; Welikala, N; Yvon, D; Zacchei, A; Zonca, A

    2015-01-01

    We present the 8th Full Focal Plane simulation set (FFP8), deployed in support of the Planck 2015 results. FFP8 consists of 10 fiducial mission realizations reduced to 18144 maps, together with the most massive suite of Monte Carlo realizations of instrument noise and CMB ever generated, comprising $10^4$ mission realizations reduced to about $10^6$ maps. The resulting maps incorporate the dominant instrumental, scanning, and data analysis effects; remaining subdominant effects will be included in future updates. Generated at a cost of some 25 million CPU-hours spread across multiple high-performance-computing (HPC) platforms, FFP8 is used for the validation and verification of analysis algorithms, as well as their implementations, and for removing biases from and quantifying uncertainties in the results of analyses of the real data.

  16. The Path of Carbon in Photosynthesis XII. Some Temperature Effects

    Science.gov (United States)

    Ouellet, C.

    1951-06-25

    The photosynthetic assimilation of radioactive carbon dioxide for two-minute periods by Scenedesmus has bee studied at temperatures ranging from 25° to 44° C. All labeled intermediates cease to be formed at about 45° C. With rising temperature, the radioactivity reaching the sugar phosphate reservoirs decreases regularly while there is a sharp maximum in sucrose at 37° C. and a less pronounced one in malic and aspartic acids about 40° C. A tentative interpretation of these effects is offered.

  17. Mid-Infrared Optoelectronics: Materials and Devices. MIOMD-XII

    Science.gov (United States)

    2014-10-01

    University, 6100 Main Street, Houston, TX 77005‐1827, USA 3Dipartimento Interateneo di Fisica , Università e Politecnico di Bari Via Amendola 173, I‐70126, Bari...Lancaster University, Lancaster, LA1 4YB, UK 2School of Physics and Astronomy, University of Nottingham, Nottingham NG7 2RD, UK 3Dipartimento di Fisica

  18. Vilma Tugi 20. II 1924 - 24. XII 2007

    Index Scriptorium Estoniae

    2008-01-01

    Kunstniku elust ja loomingust. 1942. a. astus Vilma Tugi kõrgemasse kunstikooli Pallas, 1949. aastani jätkas õpinguid Tartu Riiklikus Kunstiinstituudis. 2003. a. sai temast kunstiühingu Pallas liige

  19. 7. XII avati rahvusraamatukogu VI korruse näitusesaalis...

    Index Scriptorium Estoniae

    2005-01-01

    Hispaania Graafiliste Kunstide Akadeemia (Calcografia Nacional) koostatud ja Hispaania Suursaatkonna vahendatud näitus "Goya : portreteeritud südametunnistus". Väljas on 20 suureformaadilist digitaalpilti Francisco de Goya gravüüridest. Enne näituse avamist pidas Ramon de Villanueva loengu "Selgitusi Goya loomingu mõistmiseks"

  20. Laser-Time Interaction XII: Photochemical, Photothermal, and Photomechanical

    Science.gov (United States)

    Duncan, Donald D.; Jacques, Steven L.; Johnson, Peter C.

    2001-01-01

    This proceedings contains papers on the following topics: photodynamic therapy, immunotherapy, pulsed laser effects, polarized light interactions, photochemical interactions, occular laser effects,thermal interactions, laser shaping of cartilage.

  1. Division X, XII / Commission 40, 41 / Working Group Radio Astronomy

    NARCIS (Netherlands)

    Kellermann, Kenneth; Orchiston, Wayne; Davies, Rod; Gurvits, Leonid; Ishiguro, Masato; Lequeux, James; Swarup, Govind; Wall, Jasper; Wielebinski, Richard; van Woerden, Hugo

    The IAU Working Group on Historical Radio Astronomy (WGHRA) was formed at the 2003 General Assembly of the IAU as a Joint Working Group of Commissions 40 (Radio Astronomy) and 41 (History of Astronomy), in order to: a) assemble a master list of surviving historically-significant radio telescopes and

  2. Nina Poom 14. IX 1909 - 15. XII 2006

    Index Scriptorium Estoniae

    2007-01-01

    4. I 2007 maeti Stockholmis Nina Poom, Eduard Wiiralti tööde suurim koguja sõjajärgsel perioodil väljaspool Eestit. Põhiliselt tema kogu baasil avati Eesti Rahvusraamatukogus Eduard Wiiralti galerii

  3. XII Jornadas Nacionales y Latinoamericanas Actuariales: Tomo 2

    OpenAIRE

    Casparri, María Teresa; Bernardello, Alicia; García Fronti, Javier; Vilker, Ana Silvia

    2011-01-01

    Melinsky, Eduardo y Boietti, Alfredo: Análisis patrimonial dinámico.Caride, Verónica; De Jesús, Mauro y Vilker, Ana Silvia: Precios internacionales de commodities y ciclo económico: el caso de Latinoamérica. Zbinden, Pablo y Mutchinick, Paula: Teoría de la credibilidad: aplicación a los seguros de vida de saldos deudores. De Simoni, María Eugenia: Metodologías tradicionales y las opciones reales en las decisiones de inversión en la industria del turismo. Fernández Villa, Milagros y Mutchinick...

  4. 30. IX kuni 31. XII 2000 toimus Makedoonia Vabariigis...

    Index Scriptorium Estoniae

    2001-01-01

    III rahvusvaheline graafikatriennaal "Bitola 2000" teemadel "2000 aastat kristlust" ja "Metamorfoos". Eestist osalesid Peeter Allik, Sirje Eelma, Kelli Kagovere, Avo Keerend, Ilmar Kruusamäe, Raul Meel, Benjamin Vasserman. Peapreemia - poola graafiku Mira Boczniowiczi töö "Empire Sign".

  5. Planck 2015 results. XII. Full focal plane simulations

    Science.gov (United States)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartlett, J. G.; Bartolo, N.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Boulanger, F.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Castex, G.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Delouis, J.-M.; Désert, F.-X.; Dickinson, C.; Diego, J. M.; Dolag, K.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Ghosh, T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Karakci, A.; Keihänen, E.; Keskitalo, R.; Kiiveri, K.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lamarre, J.-M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; Lindholm, V.; López-Caniego, M.; Lubin, P. M.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Melin, J.-B.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Pearson, T. J.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Roman, M.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, B.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Welikala, N.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    We present the 8th full focal plane simulation set (FFP8), deployed in support of the Planck 2015 results. FFP8 consists of 10 fiducial mission realizations reduced to 18 144 maps, together with the most massive suite of Monte Carlo realizations of instrument noise and CMB ever generated, comprising 104 mission realizations reduced to about 106 maps. The resulting maps incorporate the dominant instrumental, scanning, and data analysis effects, and the remaining subdominant effects will be included in future updates. Generated at a cost of some 25 million CPU-hours spread across multiple high-performance-computing (HPC) platforms, FFP8 is used to validate and verify analysis algorithms and their implementations, and to remove biases from and quantify uncertainties in the results of analyses of the real data.

  6. NIHAO XII: galactic uniformity in a $\\Lambda$CDM universe

    CERN Document Server

    Dutton, Aaron A; Wang, Liang; Gutcke, Thales A; Buck, Tobias; Udrescu, Silviu M; Frings, Jonas; Stinson, Gregory S; Kang, Xi; Macciò, Andrea V

    2016-01-01

    We use a sample of 83 high-resolution cosmological zoom-in simulations and a semi-analytic model to study the stocasticity of galaxy formation in haloes ranging from dwarf ($M_{200} \\sim 10^{10} M_{\\odot}$) to Milky Way ($M_{200}\\sim 10^{12}M_{\\odot}$) masses. Our simulated galaxies reproduce the observed inefficiency of galaxy formation as expressed through the stellar, gas and baryonic Tully-Fisher (TF) relations. The scatter in our simulated TF relations is very small, and velocity dependent. For HI velocities in the range ($70 < V < 220$ km/s), the scatter is just 0.08 to 0.14 dex, consistent with the observed intrinsic scatter. At low velocities ($20 < V < 70$ km/s), the simulated scatter is 0.20-0.25 dex, which could be tested with future observations. The scatter in the stellar mass vs dark halo velocity relation is constant for $30 < V < 200$ km/s, and smaller ($\\simeq 0.17$ dex) when using the maximum circular velocity of the dark matter only simulation, $V_{max}^{DMO}$, compared to...

  7. 7. XII avati rahvusraamatukogu VI korruse näitusesaalis...

    Index Scriptorium Estoniae

    2005-01-01

    Hispaania Graafiliste Kunstide Akadeemia (Calcografia Nacional) koostatud ja Hispaania Suursaatkonna vahendatud näitus "Goya : portreteeritud südametunnistus". Väljas on 20 suureformaadilist digitaalpilti Francisco de Goya gravüüridest. Enne näituse avamist pidas Ramon de Villanueva loengu "Selgitusi Goya loomingu mõistmiseks"

  8. Global Factor Trade with Differentiated Factor Prices and Factor Intensities

    OpenAIRE

    Yun-kwong Kwok

    2004-01-01

    Relaxing the assumption of internationally identical factor intensity techniques in the HOV model creates two challenges. First, computing actual factor intensity techniques of different countries requires detailed input-output tables and factor usage data, which are not always available. Second, determinants of the factor intensity technique differences across countries need to be identified. This paper explores the role of relative factor price differences in the determination of factor int...

  9. Melhoramento do cafeeiro: XII - Variabilidade em linhas puras de café Coffee breeding: XII - Variability within isogenic coffee progenies

    Directory of Open Access Journals (Sweden)

    H. Antunes Filho

    1957-01-01

    Full Text Available Três progênies isogênicas de café Bourbon Vermelho, duas oriundas de cafeeiros haplóides (357-21 e RP 13 que tiveram os cromossomos duplicados e outra correspondente ao F1 (H 1934 do cruzamento entre esses dois cafeeiros, foram estudadas com relação a vários característicos, em um ensaio tipo látice balanceado, onde entraram 13 outras progênies de origens diversas. Dentre estas destacam-se as progênies Bourbon Vermelho 959 correspondente a S0, 43-18-11 correspondente a S3 do cafeeiro 43 e 43-7-7-15 e 43-7-19-13 correspondente a S4 dessa mesma planta, as quais também foram analisadas com detalhes. Com relação à altura das plantas no campo não se notou heterose no híbrido Fr que apresenta altura média intermediária. Também as autofecundações sucessivas parecem não influir na redução do vigor vegetativo. Os dados obtidos foram aproveitados para análise da variabilidade desse característico, calculando-se a variância para os canteiros e a variância total, bem como sua homogeneidade. Notou-se que Fx apresenta variância igual à de uma das linhas puras e muito próxima da outra. Das duas linhas puras, a de número 357-21Dp mostrou-se pouco mais variável, cinco anos após a transplantação para o local definitivo. Embora o híbrido F1 tenha produzido mais café cereja no conjunto de três anos do que as linhas puras, a diferença não foi significativa. O híbrido se mostrou menos variável quanto a este característico, embora as variâncias não sejam também significativamente diferentes. Nas outras progénies estudadas os valores da variância foram bem maiores, com tendência de aumento com as sucessivas autofecundações. As linhas isogênicas analisadas ano por ano deram indicações de que a variância do híbrido permaneceu menor, com exceção de um ano apenas. Variação bem acentuada foi encontrada entre as progénies constantes do ensaio no tocante às porcentagens de sementes do tipo moca. O híbrido H 1934 apresentou menor quantidade de sementes moca do que as linhas puras e significativamente menos que a progênie 357-21 Dp. Quanto à variabilidade, a do híbrido se mostrou intermediária, aproximando-se da linha pura com variância maior. As variâncias das outras progênies estudadas são bem mais elevadas, notando-se tendência de aumento com as autofecundações sucessivas. Com relação às sementes concha, a porcentagem média para o híbrido não difere das linhas puras e o valor da variância é intermediário. Para as demais progênies analisadas os valores das variâncias são maiores e mostram tendência de redução com as autofecundações. O valor da peneira média correspondente ao tamanho das sementes não difere para as três linhas isogênicas, a variabilidade sendo, porém, menor para o híbrido. Para as outras progênies não se notou redução do tamanho como efeito da autofecundação e as suas variâncias não mostram tendência de aumento ou redução nas gerações estudadas. Dos itens analisados, destacam-se como mais promissores do ponto de vista da produção e altura das plantas (a qual pode representar o vigor vegetativo a progénie de Bourbon Vermelho 959 e a de Bourbon Amarelo J 24ex. Dependendo do característico analisado, notou-se que a variância entre plantas nos canteiros do híbrido F1 pode ser igual, intermediária ou menor do que a das linhas puras. Em nenhum caso, porém, a variância do híbrido se mostrou maior que a das linhas puras.Three isogenic progenies of Red Bourbon coffee (Coffea arabica L.var. bourbon (B. Rodr. Choussy were investigated in relation to several characteristics in a balanced lattice experiment with 16 entries, five replications, each plot with four individual plants. Two of these isogenic progenies were obtained by artificial self-pollination of two plants which were derived from haploid sporophytes after their chromosomes were duplicated (357-21 and RP 13. The third isogenic progeny is the F1 of the hybrid between those duplicated plants (H 1934. Among the remaining 13 entries of this trial more attention was given to the following progenies of Red Bourbon coffee: 959, S0 from open pollinated seeds taken in a private farm; 43-18-11, selfed S3 from a selected plant; 43-7-7-15 and 43-7-19-13, selfed S4 progenies of similar pedigrees. Plant height was measured for all entries five years after transplantation to the field. It was observed that the F1 did not show heterosis for this characteristic, its average height being intermediate between those of the two isogenic progenies. The within plot variance presented by the F1 is equal to that of one of the pure lines and close to that of the other. The average height presented by the S3 and the S4 progenies originally derived from plant C 43 suggests that successive selfing does not reduce plant height (Table 3. Total yields in kilograms of riped fruits of individual plants were recorded for the first three years of crops. The mean yield of the F1 is higher than those of the two isogenic lines, although this difference is not significant. The within plot variance of yields is smaller for the F1 than for the two pure lines, but again the differences are not significant. When separate analyses were made for the annual crops of the three isogenic progenies, it was seen that the smallest within plot variance was presented by the F1 in two of the three years. The within plot variances for the total yields of the S3 and S4 progenies were higher than those presented by the isogenic progenies, showing a tendency to become larger with successive selfings (Tables 4 and 5. Observations were also made on the percentages of three different seed types produced by coffee plants, namely, the flat, normal seeds, "moca" (peaberry and "concha" seeds. "Moca" seeds result from the development of a single ovule after a precocious abortion of the second ovule in the ovary. "Concha" seeds are those born from independent ovules which may eventually occur in the same fruit lo-cule. Abnormal frequencies of these abnormal seed types are clearly under genetic control and apparently the percentage of "moca" beans is more subjected to environmental influences. Lower percentages of "moca" seeds were found for the F1 hybrid than for the two pure lines. The value of the F1 variance for percentage of "moca" is intermediate between those of the pure lines and closer to the highest vafcie. Higher variances in the percentage of this seed type were found for the other progenies, showing also a tendency to increase with more generations of selfing. The percentages of "concha" seeds were not different among the three isogenic lines, the F1 variance for this seed type being intermediate. Higher variances for the percentage of "concha" seeds were found for the other progenies, together with an indication that successive selfings may reduce the incidence of this seed types (Tables 6 and 7. Seed size was graded for all plants during the three years of crop in a series of sieves differing by 1/64 of an inch. No differences were noticed between isogenic progenies, although the F1 variance for seed size was lower (Table 8. It is concluded that a definite trend can not be observed for the variability within isogenic progenies of the arabian coffee plant, which is a predominantly autogamous species. Depending on the characteristic under observation, the variances of the F1 hybrid may be lower, equal to or higher than the variances presented by the isogenic progenies of the homozygous plants that entered the cross. (Table 9. Although these data refer only to the first three years of crop, it may be pointed out that no instance was found where the Fx presented higher variances than those of the two isogenic progenies.

  10. Design, Analysis, and Interpretation of Screening Studies for Human Factors Engineering Research. Revision.

    Science.gov (United States)

    1978-06-01

    141 11 Geometric Representation of One Main Effect, A, in a 25 Experiment with Two Responses . . . 154 xii It I. INTRODUCTION Screoning...perimenter should first use procedures that help reduce or 0 eliminate unwanted trend effects. Next, he should assign 119 , 0 -I - TABLA 14 $ ESTTMATING

  11. Ex vivo effects of low-dose rivaroxaban on specific coagulation assays and coagulation factor activities in patients under real life conditions.

    Science.gov (United States)

    Mani, Helen; Hesse, Christian; Stratmann, Gertrud; Lindhoff-Last, Edelgard

    2013-01-01

    Global coagulation assays display variable effects at different concentrations of rivaroxaban. The aim of this study is to quantify the ex vivo effects of low-dose rivaroxaban on thrombophilia screening assays and coagulation factor activities based on the administration time, and to show how to mask possible interferences. Plasma samples from 40 patients receiving rivaroxaban 10 mg daily were investigated to measure activities of clotting factor II, V, VII, VIII, IX, XI, XII and XIII; protein C- and protein S-levels; lupus anticoagulants; anticardiolipin IgG and IgM; D-dimer, heparin-platelet factor 4 (HPF4) antibodies and screening tests for von Willebrand disease (VWD). Two hours after rivaroxaban administration, the activities of clotting factors were significantly decreased to different extents, except for factor XIII. Dilution of plasma samples resulted in neutralisation of these interferences. The chromogenic protein C activity assay was not affected by rivaroxaban. Depending on the timing of tablet intake in relation to blood sampling protein S activity was measured falsely high when a clotting assay was used. False-positive results for lupus anticoagulants were observed depending on the assay system used and the administration time of rivaroxaban. ELISA-based assays such as anticardiolipin IgG and IgM, D-dimer, HPF4-antibodies and the turbidimetric assays for VWD were not affected by rivaroxaban. Specific haemostasis clotting tests should be performed directly prior to rivaroxaban intake. Assay optimisation in the presence of rivaroxaban can be achieved by plasma dilution. Immunologic assays are not influenced by rivaroxaban, while chromogenic assays can be used, when they do not depend on factor Xa.

  12. DNA barcoding for identification of 'Candidatus Phytoplasmas' using a fragment of the elongation factor Tu gene.

    Directory of Open Access Journals (Sweden)

    Olga Makarova

    Full Text Available BACKGROUND: Phytoplasmas are bacterial phytopathogens responsible for significant losses in agricultural production worldwide. Several molecular markers are available for identification of groups or strains of phytoplasmas. However, they often cannot be used for identification of phytoplasmas from different groups simultaneously or are too long for routine diagnostics. DNA barcoding recently emerged as a convenient tool for species identification. Here, the development of a universal DNA barcode based on the elongation factor Tu (tuf gene for phytoplasma identification is reported. METHODOLOGY/PRINCIPAL FINDINGS: We designed a new set of primers and amplified a 420-444 bp fragment of tuf from all 91 phytoplasmas strains tested (16S rRNA groups -I through -VII, -IX through -XII, -XV, and -XX. Comparison of NJ trees constructed from the tuf barcode and a 1.2 kbp fragment of the 16S ribosomal gene revealed that the tuf tree is highly congruent with the 16S rRNA tree and had higher inter- and intra- group sequence divergence. Mean K2P inter-/intra- group divergences of the tuf barcode did not overlap and had approximately one order of magnitude difference for most groups, suggesting the presence of a DNA barcoding gap. The use of the tuf barcode allowed separation of main ribosomal groups and most of their subgroups. Phytoplasma tuf barcodes were deposited in the NCBI GenBank and Q-bank databases. CONCLUSIONS/SIGNIFICANCE: This study demonstrates that DNA barcoding principles can be applied for identification of phytoplasmas. Our findings suggest that the tuf barcode performs as well or better than a 1.2 kbp fragment of the 16S rRNA gene and thus provides an easy procedure for phytoplasma identification. The obtained sequences were used to create a publicly available reference database that can be used by plant health services and researchers for online phytoplasma identification.

  13. [Денис Хрусталëв. Северные крестоносцы: Русь в борьбе за сферы влияния в Восточной Прибалтике XII-XIII вв.] / Andris Šnē

    Index Scriptorium Estoniae

    Šnē, Andris, 1973-

    2012-01-01

    Arvustus: Хрусталëв, Денис. Северные крестоносцы: Русь в борьбе за сферы влияния в Восточной Прибалтике XII-XIII вв. (Санкт-Петербург: Евразия, 2009)

  14. The effect of nine common polymorphisms in coagulation factor genes (F2, F5, F7, F12 and F13 ) on the effectiveness of statins: the GenHAT study.

    Science.gov (United States)

    Maitland-van der Zee, Anke-Hilse; Peters, Bas J M; Lynch, Amy I; Boerwinkle, Eric; Arnett, Donna K; Cheng, Suzanne; Davis, Barry R; Leiendecker-Foster, Catherine; Ford, Charles E; Eckfeldt, John H

    2009-05-01

    Pharmacogenetic research has shown that genetic variation may influence statin responsiveness. Statins exert a variety of beneficial effects beyond lipid lowering, including antithrombotic effects, which contribute to the risk reduction of cardiovascular disease. Statins have been shown to influence the expression of coagulation factors II, V, VII, XII and XIII. Data from a large randomized clinical trial of pravastatin, designed to show efficacy relative to usual care, were used to investigate whether a pharmacogenetic effect of polymorphisms in genes coding for coagulation factors II, V, VII, XII and XIII is associated with reduced fatal coronary heart disease (CHD) and nonfatal myocardial infarction, combined CHD and all-cause mortality. The Genetics of Hypertension Associated Treatment is an ancillary study of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. The genotyped population in the lipid-lowering trial of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial included 9624 participants randomly assigned to pravastatin or to usual care. The efficacy of pravastatin in reducing risk of all-cause mortality, CHD and nonfatal myocardial infarction and combined CHD, was compared among genotype strata by examining an interaction term in a proportional hazards model. None of the polymorphisms were associated with the clinical outcomes. For the F7 (-323) ins/del polymorphism there was no interaction with pravastatin for either outcome. For both the F5 Arg506Gln G>A (rs6025) polymorphism and F7 Arg353Gln G>A (rs6046) polymorphism there were no interactions with pravastatin in relation to all-cause mortality, but there were significant interactions with combined CHD [interaction hazard ratio = 1.33, 95% confidence interval (1.01-1.76) and interaction hazard ratio = 1.92, 95% confidence interval (1.00-3.65), respectively]. There were no interactions between the polymorphisms in the other coagulation genes and

  15. Factor II deficiency

    Science.gov (United States)

    ... if one or more of these factors are missing or are not functioning like they should. Factor II is one such coagulation factor. Factor II deficiency runs in families (inherited) and is very rare. Both parents must ...

  16. Factor VII deficiency

    Science.gov (United States)

    ... if one or more of these factors are missing or are not functioning like they should. Factor VII is one such coagulation factor. Factor VII deficiency runs in families (inherited) and is very rare. Both parents must ...

  17. Heart disease - risk factors

    Science.gov (United States)

    Heart disease - prevention; CVD - risk factors; Cardiovascular disease - risk factors; Coronary artery disease - risk factors; CAD - risk ... a certain health condition. Some risk factors for heart disease you cannot change, but some you can. ...

  18. Thyroid Cancer Risk Factors

    Science.gov (United States)

    ... Prevented? Thyroid Cancer Causes, Risk Factors, and Prevention Thyroid Cancer Risk Factors A risk factor is anything that ... Cancer? Can Thyroid Cancer Be Prevented? More In Thyroid Cancer About Thyroid Cancer Causes, Risk Factors, and Prevention ...

  19. Risk Factors and Prevention

    Science.gov (United States)

    ... Factors & Prevention Back to Patient Resources Risk Factors & Prevention Even people who look healthy and free of ... as possible. Share: The Normal Heart Risk Factors & Prevention Heart Diseases & Disorders Substances & Heart Rhythm Disorders Symptoms & ...

  20. Risk Factors for Scleroderma

    Science.gov (United States)

    ... You are here: Home For Patients Risk Factors Risk Factors for Scleroderma The cause of scleroderma is ... what biological factors contribute to scleroderma pathogenesis. Genetic Risk Scleroderma does not tend to run in families ...

  1. Factor V deficiency

    Science.gov (United States)

    ... When certain blood clotting factors are low or missing, your blood does not clot properly. Factor V deficiency is rare. It may be caused by: A defective Factor V gene passed down through families (inherited) An antibody that interferes with normal Factor ...

  2. Foundations of factor analysis

    CERN Document Server

    Mulaik, Stanley A

    2009-01-01

    Introduction Factor Analysis and Structural Theories Brief History of Factor Analysis as a Linear Model Example of Factor AnalysisMathematical Foundations for Factor Analysis Introduction Scalar AlgebraVectorsMatrix AlgebraDeterminants Treatment of Variables as Vectors Maxima and Minima of FunctionsComposite Variables and Linear Transformations Introduction Composite Variables Unweighted Composite VariablesDifferentially Weighted Composites Matrix EquationsMulti

  3. ISS Payload Human Factors

    Science.gov (United States)

    Ellenberger, Richard; Duvall, Laura; Dory, Jonathan

    2016-01-01

    The ISS Payload Human Factors Implementation Team (HFIT) is the Payload Developer's resource for Human Factors. HFIT is the interface between Payload Developers and ISS Payload Human Factors requirements in SSP 57000. ? HFIT provides recommendations on how to meet the Human Factors requirements and guidelines early in the design process. HFIT coordinates with the Payload Developer and Astronaut Office to find low cost solutions to Human Factors challenges for hardware operability issues.

  4. DNA Barcoding for Identification of "Candidatus Phytoplasmas" Using a Fragment of the Elongation Factor Tu Gene

    DEFF Research Database (Denmark)

    Makarova, Olga; Contaldo, Nicoletta; Paltrinieri, Samanta

    2012-01-01

    /Principal Findings We designed a new set of primers and amplified a 420–444 bp fragment of tuf from all 91 phytoplasmas strains tested (16S rRNA groups -I through -VII, -IX through -XII, -XV, and -XX). Comparison of NJ trees constructed from the tuf barcode and a 1.2 kbp fragment of the 16S ribosomal gene revealed...... by plant health services and researchers for online phytoplasma identification....

  5. Bayesian Exploratory Factor Analysis

    DEFF Research Database (Denmark)

    Conti, Gabriella; Frühwirth-Schnatter, Sylvia; Heckman, James J.;

    2014-01-01

    This paper develops and applies a Bayesian approach to Exploratory Factor Analysis that improves on ad hoc classical approaches. Our framework relies on dedicated factor models and simultaneously determines the number of factors, the allocation of each measurement to a unique factor, and the corr......This paper develops and applies a Bayesian approach to Exploratory Factor Analysis that improves on ad hoc classical approaches. Our framework relies on dedicated factor models and simultaneously determines the number of factors, the allocation of each measurement to a unique factor......, and the corresponding factor loadings. Classical identification criteria are applied and integrated into our Bayesian procedure to generate models that are stable and clearly interpretable. A Monte Carlo study confirms the validity of the approach. The method is used to produce interpretable low dimensional aggregates...

  6. Risk Factors for Thrombosis

    Institute of Scientific and Technical Information of China (English)

    包承鑫

    2002-01-01

    @@ Thrombotic disease is a multifactorial disease, multiple interactions between genetic and environmental factors contribute to the development of the disease.This review summarized some risk factors reported for arterial thrombosis and venous thrombosis in recent few years.

  7. Factoring Polynomials and Fibonacci.

    Science.gov (United States)

    Schwartzman, Steven

    1986-01-01

    Discusses the factoring of polynomials and Fibonacci numbers, offering several challenges teachers can give students. For example, they can give students a polynomial containing large numbers and challenge them to factor it. (JN)

  8. Coagulation Factors Test

    Science.gov (United States)

    ... be limited. Home Visit Global Sites Search Help? Coagulation Factors Share this page: Was this page helpful? ... else I should know? How is it used? Coagulation factor testing is performed to determine if a ...

  9. Annual Adjustment Factors

    Data.gov (United States)

    Department of Housing and Urban Development — The Department of Housing and Urban Development establishes the rent adjustment factors - called Annual Adjustment Factors (AAFs) - on the basis of Consumer Price...

  10. Environmental factors in autism

    OpenAIRE

    Andreas Martin Grabrucker

    2013-01-01

    Autism is a neurodevelopmental disorders characterized by impairments in communication and social behavior, and by repetitive behaviors. Although genetic factors might be largely responsible for the occurrence of autism they cannot fully account for all cases and it is likely that in addition to a certain combination of autism-related genes, specific environmental factors might act as risk factors triggering the development of autism. Thus, the role of environmental factors in autism is an im...

  11. Environmental Factors in Autism

    OpenAIRE

    Andreas M. Grabrucker

    2013-01-01

    Autism is a neurodevelopmental disorders characterized by impairments in communication and social behavior, and by repetitive behaviors. Although genetic factors might be largely responsible for the occurrence of autism they cannot fully account for all cases and it is likely that in addition to a certain combination of autism-related genes, specific environmental factors might act as risk factors triggering the development of autism. Thus, the role of environmental factors in autism is an im...

  12. Mesonic Form Factors

    Energy Technology Data Exchange (ETDEWEB)

    Frederic D. R. Bonnet; Robert G. Edwards; George T. Fleming; Randal Lewis; David Richards

    2003-07-22

    We have started a program to compute the electromagnetic form factors of mesons. We discuss the techniques used to compute the pion form factor and present preliminary results computed with domain wall valence fermions on MILC asqtad lattices, as well as Wilson fermions on quenched lattices. These methods can easily be extended to rho-to-gamma-pi transition form factors.

  13. Multilevel Mixture Factor Models

    Science.gov (United States)

    Varriale, Roberta; Vermunt, Jeroen K.

    2012-01-01

    Factor analysis is a statistical method for describing the associations among sets of observed variables in terms of a small number of underlying continuous latent variables. Various authors have proposed multilevel extensions of the factor model for the analysis of data sets with a hierarchical structure. These Multilevel Factor Models (MFMs)…

  14. Bayesian Exploratory Factor Analysis

    DEFF Research Database (Denmark)

    Conti, Gabriella; Frühwirth-Schnatter, Sylvia; Heckman, James J.

    2014-01-01

    This paper develops and applies a Bayesian approach to Exploratory Factor Analysis that improves on ad hoc classical approaches. Our framework relies on dedicated factor models and simultaneously determines the number of factors, the allocation of each measurement to a unique factor......, and the corresponding factor loadings. Classical identification criteria are applied and integrated into our Bayesian procedure to generate models that are stable and clearly interpretable. A Monte Carlo study confirms the validity of the approach. The method is used to produce interpretable low dimensional aggregates...

  15. The regime of sediment transport in the Soloneţ Catchment (Romania): quantification of the controlling factors

    Science.gov (United States)

    Niga, Bogdan; Obreja, Florin; Robu, Delia; Rǎdoane, Maria

    2016-04-01

    This paper focuses on the regime of sediment transportation to the river mouth of a catchment of 206 km2, located on the easternmost side of the Eastern Carpathians (NE Romania). The primary aim of the paper is to attempt a quantification of the catchment controlling factors of the sediment volume transited through the drainage network and their annual and multi-annual distribution. Among these factors we will focus on the role of sediment sources and human interventions in the mobilization of sediments towards rivers. The data employed in this study were obtained from the Parhauti gauging station (1973 to 2014), located at a distance of about 1.7 km from the confluence of the Solonet River with the Suceava River. These are represented of measurements of water discharge, suspended sediment discharge (hourly or daily measurements during flash flood intervals) and monthly values. The data were correlated with records on rainfall, local slope and morphological characteristics of the river crosssection. For a more detailed analysis we introduced a further comparison with records obtained at other gauging stations, located within the same physical-geographical settings, in neighboring catchments. Regarding our study catchment, investigations were performed on all variables that control flow formation and sediment load of water flows, i.e. geologic substrate, landforms, catchment morphometry, characteristics of the drainage network, land use, types of human interventions in the catchment area and on the river network. The average drainage network density equals ca. 2.5 km / km2, ranging from less than 1 km / km2 at the watershed, to the maximum of over 4 km / km2 recorded at the cuesta frontslopes. The multi-annual average amount of suspended sediment transport is 3.06 kg / s. Suspended sediment transport occurs most intensely during summer (months VI-VIII), (59.8%) as a result of floods which enhance the power of the river. During winter months (XII-II), sediment

  16. Analytic Couple Modeling Introducing Device Design Factor, Fin Factor, Thermal Diffusivity Factor, and Inductance Factor

    Science.gov (United States)

    Mackey, Jon; Sehirlioglu, Alp; Dynys, Fred

    2014-01-01

    A set of convenient thermoelectric device solutions have been derived in order to capture a number of factors which are previously only resolved with numerical techniques. The concise conversion efficiency equations derived from governing equations provide intuitive and straight-forward design guidelines. These guidelines allow for better device design without requiring detailed numerical modeling. The analytical modeling accounts for factors such as i) variable temperature boundary conditions, ii) lateral heat transfer, iii) temperature variable material properties, and iv) transient operation. New dimensionless parameters, similar to the figure of merit, are introduced including the device design factor, fin factor, thermal diffusivity factor, and inductance factor. These new device factors allow for the straight-forward description of phenomenon generally only captured with numerical work otherwise. As an example a device design factor of 0.38, which accounts for thermal resistance of the hot and cold shoes, can be used to calculate a conversion efficiency of 2.28 while the ideal conversion efficiency based on figure of merit alone would be 6.15. Likewise an ideal couple with efficiency of 6.15 will be reduced to 5.33 when lateral heat is accounted for with a fin factor of 1.0.

  17. Explicit correlation factors

    Science.gov (United States)

    Johnson, Cole M.; Hirata, So; Ten-no, Seiichiro

    2017-09-01

    We analyze the performance of 17 different correlation factors in explicitly correlated second-order many-body perturbation calculations for correlation energies. Highly performing correlation factors are found to have near-universal shape and size in the short range of electron-electron distance (0 1.5 a.u.) is insignificant insofar as the factor becomes near constant, leaving an orbital expansion to describe decoupled electrons. An analysis based on a low-rank Taylor expansion of the correlation factor seems limited, except that a negative second derivative with the value of around -1.3 a.u. correlates with high performance.

  18. Rh Factor Blood Test

    Science.gov (United States)

    Tests and Procedures Rh factor blood test By Mayo Clinic Staff Rhesus (Rh) factor is an inherited protein found on the surface of ... If your blood has the protein, you're Rh positive. If your blood lacks the protein, you' ...

  19. Baryon form factors

    CERN Document Server

    Kubis, B; Meißner, Ulf G; Mei{\\ss}ner, Ulf-G.

    1999-01-01

    We calculate the form factors of the baryon octet in the framework of heavy baryon chiral perturbation theory. The calculated charge radius of the show that kaon loop effects can play a significant role in the neutron electric form factor. Furthermore. we derive generalized Caldi-Pagels relations between various charge radii which are free of chiral loop effects.

  20. Overview of environmental factors

    Science.gov (United States)

    Purvis, C. K.

    1989-01-01

    The orbital environment is complex, dynamic, and comprised of both natural and system-induced components. Several environment factors are important for materials. Materials selection/suitability determination requires consideration of each and all factors, including synergisms among them. Understanding and evaluating these effects will require ground testing, modeling, and focused flight experimentation.

  1. The Transcription Factor Encyclopedia

    DEFF Research Database (Denmark)

    Yusuf, Dimas; Butland, Stefanie L; Swanson, Magdalena I

    2012-01-01

    ABSTRACT: Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130...

  2. Factors of schizoid personality.

    Science.gov (United States)

    Raine, A; Allbutt, J

    1989-02-01

    The increasing use of schizoid personality scales with normals has led to a number of validation studies, but to date there are no published analyses of the factorial structure of these scales. This study presents results of factor analyses of schizoid personality scales in an initial attempt to delineate their factorial structure. Questionnaires were administered to 114 male and female undergraduates and factor analysed using Varimax, Quartimax, and Oblique rotations. A two-factor varimax solution yielded a first factor accounting for 49 per cent of total unrotated variance with high (0.70 to 0.91) loadings from Hallucinatory predisposition, Perceptual aberration, Schizophrenism, STA and STB scales, and was interpreted as reflecting a general factor of schizoid personality disorder. Psychoticism and Social anhedonia loaded on a second factor accounting for 20 per cent of the variance which was uncorrelated (r = 0.09) with factor 1. This factor solution was closely replicated using quartimax and oblimin rotation criteria. It is concluded that Social anhedonia and Psychoticism represent a separate dimension from other scales which reflect the more positive features of schizoid personality.

  3. Factorized Graph Matching.

    Science.gov (United States)

    Zhou, Feng; de la Torre, Fernando

    2015-11-19

    Graph matching (GM) is a fundamental problem in computer science, and it plays a central role to solve correspondence problems in computer vision. GM problems that incorporate pairwise constraints can be formulated as a quadratic assignment problem (QAP). Although widely used, solving the correspondence problem through GM has two main limitations: (1) the QAP is NP-hard and difficult to approximate; (2) GM algorithms do not incorporate geometric constraints between nodes that are natural in computer vision problems. To address aforementioned problems, this paper proposes factorized graph matching (FGM). FGM factorizes the large pairwise affinity matrix into smaller matrices that encode the local structure of each graph and the pairwise affinity between edges. Four are the benefits that follow from this factorization: (1) There is no need to compute the costly (in space and time) pairwise affinity matrix; (2) The factorization allows the use of a path-following optimization algorithm, that leads to improved optimization strategies and matching performance; (3) Given the factorization, it becomes straight-forward to incorporate geometric transformations (rigid and non-rigid) to the GM problem. (4) Using a matrix formulation for the GM problem and the factorization, it is easy to reveal commonalities and differences between different GM methods. The factorization also provides a clean connection with other matching algorithms such as iterative closest point; Experimental results on synthetic and real databases illustrate how FGM outperforms state-of-the-art algorithms for GM. The code is available at http://humansensing.cs.cmu.edu/fgm.

  4. Risk Factors for Tuberculosis

    Directory of Open Access Journals (Sweden)

    Padmanesan Narasimhan

    2013-01-01

    Full Text Available The risk of progression from exposure to the tuberculosis bacilli to the development of active disease is a two-stage process governed by both exogenous and endogenous risk factors. Exogenous factors play a key role in accentuating the progression from exposure to infection among which the bacillary load in the sputum and the proximity of an individual to an infectious TB case are key factors. Similarly endogenous factors lead in progression from infection to active TB disease. Along with well-established risk factors (such as human immunodeficiency virus (HIV, malnutrition, and young age, emerging variables such as diabetes, indoor air pollution, alcohol, use of immunosuppressive drugs, and tobacco smoke play a significant role at both the individual and population level. Socioeconomic and behavioral factors are also shown to increase the susceptibility to infection. Specific groups such as health care workers and indigenous population are also at an increased risk of TB infection and disease. This paper summarizes these factors along with health system issues such as the effects of delay in diagnosis of TB in the transmission of the bacilli.

  5. Environmental factors in autism.

    Science.gov (United States)

    Grabrucker, Andreas M

    2012-01-01

    Autism is a neurodevelopmental disorders characterized by impairments in communication and social behavior, and by repetitive behaviors. Although genetic factors might be largely responsible for the occurrence of autism they cannot fully account for all cases and it is likely that in addition to a certain combination of autism-related genes, specific environmental factors might act as risk factors triggering the development of autism. Thus, the role of environmental factors in autism is an important area of research and recent data will be discussed in this review. Interestingly, the results show that many environmental risk factors are interrelated and their identification and comparison might unveil a common scheme of alterations on a contextual as well as molecular level. For example, both, disruption in the immune system and in zinc homeostasis may affect synaptic transmission in autism. Thus, here, a model is proposed that interconnects the most important and scientifically recognized environmental factors. Moreover, similarities in how these risk factors impact synapse function are discussed and a possible influence on an already well described genetic pathway leading to the development of autism via zinc homeostasis is proposed.

  6. Environmental factors in autism

    Directory of Open Access Journals (Sweden)

    Andreas Martin Grabrucker

    2013-01-01

    Full Text Available Autism is a neurodevelopmental disorders characterized by impairments in communication and social behavior, and by repetitive behaviors. Although genetic factors might be largely responsible for the occurrence of autism they cannot fully account for all cases and it is likely that in addition to a certain combination of autism-related genes, specific environmental factors might act as risk factors triggering the development of autism. Thus, the role of environmental factors in autism is an important area of research and recent data will be discussed in this review. Interestingly, the results show that many environmental risk factors are interrelated and their identification and comparison might unveil a common scheme of alterations on a contextual as well as molecular level. For example, both, disruption in the immune system and in zinc homeostasis may affect synaptic transmission in autism. Thus, here, a model is proposed that interconnects the most important and scientifically recognized environmental factors. Moreover, similarities in how these risk factors impact synapse function are discussed and a possible influence on an already well described genetic pathway leading to the development of autism via zinc homeostasis is proposed.

  7. Factor V Leiden thrombophilia.

    Science.gov (United States)

    Kujovich, Jody Lynn

    2011-01-01

    Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to activated Protein C and an increased risk for venous thromboembolism. Deep venous thrombosis and pulmonary embolism are the most common manifestations, but thrombosis in unusual locations also occurs. The current evidence suggests that the mutation has at most a modest effect on recurrence risk after initial treatment of a first venous thromboembolism. Factor V Leiden is also associated with a 2- to 3-fold increased relative risk for pregnancy loss and possibly other obstetric complications, although the probability of a successful pregnancy outcome is high. The clinical expression of Factor V Leiden is influenced by the number of Factor V Leiden alleles, coexisting genetic and acquired thrombophilic disorders, and circumstantial risk factors. Diagnosis requires the activated Protein C resistance assay (a coagulation screening test) or DNA analysis of the F5 gene, which encodes the Factor V protein. The first acute thrombosis is treated according to standard guidelines. Decisions regarding the optimal duration of anticoagulation are based on an individualized assessment of the risks for venous thromboembolism recurrence and anticoagulant-related bleeding. In the absence of a history of thrombosis, long-term anticoagulation is not routinely recommended for asymptomatic Factor V Leiden heterozygotes, although prophylactic anticoagulation may be considered in high-risk clinical settings. In the absence of evidence that early diagnosis reduces morbidity or mortality, decisions regarding testing at-risk family members should be made on an individual basis.

  8. Two-factor authentication

    CERN Document Server

    Stanislav, Mark

    2015-01-01

    During the book, readers will learn about the various technical methods by which two-factor authentication is implemented, security concerns with each type of implementation, and contextual details to frame why and when these technologies should be used. Readers will also be provided with insight about the reasons that two-factor authentication is a critical security control, events in history that have been important to prove why organization and individual would want to use two factor, and core milestones in the progress of growing the market.

  9. Teratogenic factors affect transcription factor expression.

    Science.gov (United States)

    Kojima, Takuya; Asano, Shinya; Takahashi, Naoki

    2013-01-01

    Chemical compounds are produced every day, many with adverse effects on human health, and hence it is vital to predict the risks to humans simply, rapidly, and accurately. Teratogens have a serious impact on fetal development. This has been studied mainly by phenotypic analysis of experimental animals. However, since phenotypes can vary within different species, we established a new evaluation system based on our recent finding that teratogens influence Hox gene expression in mice. Similarly to the Hox gene expression changes, the expression patterns of several transcription factors involved in development, including the Dlx, Irx, Sall, and T-box families, were altered after 6 h of exposure to retinoic acid (RA) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The expression changes in Dlx4, Dlx6, Irx5, Sall2, Sall3, Sall4, Tbx10, and Tbx22 were linked to teratogen-induced phenotypes, and our results indicate that expression changes in developmental transcription factors can help to predict teratogenic risk.

  10. Rhoptry Proteins ROP5 and ROP18 Are Major Murine Virulence Factors in Genetically Divergent South American Strains of Toxoplasma gondii.

    Directory of Open Access Journals (Sweden)

    Michael S Behnke

    2015-08-01

    Full Text Available Toxoplasma gondii has evolved a number of strategies to evade immune responses in its many hosts. Previous genetic mapping of crosses between clonal type 1, 2, and 3 strains of T. gondii, which are prevalent in Europe and North America, identified two rhoptry proteins, ROP5 and ROP18, that function together to block innate immune mechanisms activated by interferon gamma (IFNg in murine hosts. However, the contribution of these and other virulence factors in more genetically divergent South American strains is unknown. Here we utilized a cross between the intermediately virulent North American type 2 ME49 strain and the highly virulent South American type 10 VAND strain to map the genetic basis for differences in virulence in the mouse. Quantitative trait locus (QTL analysis of this new cross identified one peak that spanned the ROP5 locus on chromosome XII. CRISPR-Cas9 mediated deletion of all copies of ROP5 in the VAND strain rendered it avirulent and complementation confirmed that ROP5 is the major virulence factor accounting for differences between type 2 and type 10 strains. To extend these observations to other virulent South American strains representing distinct genetic populations, we knocked out ROP5 in type 8 TgCtBr5 and type 4 TgCtBr18 strains, resulting in complete loss of virulence in both backgrounds. Consistent with this, polymorphisms that show strong signatures of positive selection in ROP5 were shown to correspond to regions known to interface with host immunity factors. Because ROP5 and ROP18 function together to resist innate immune mechanisms, and a significant interaction between them was identified in a two-locus scan, we also assessed the role of ROP18 in the virulence of South American strains. Deletion of ROP18 in South American type 4, 8, and 10 strains resulted in complete attenuation in contrast to a partial loss of virulence seen for ROP18 knockouts in previously described type 1 parasites. These data show that ROP5

  11. TMDs, universality and factorization

    CERN Document Server

    D'Alesio, Umberto

    2011-01-01

    We present a short overview on transverse momentum dependent parton distribution and fragmentation functions, giving their partonic interpretation and ways to access them. We then discuss the issue of their universality and its connection to factorization in perturbative QCD.

  12. Factor V Leiden

    Science.gov (United States)

    ... increase your chance of developing abnormal blood clots (thrombophilia), usually in your veins. Most people with factor ... sharp tools. References Bauer KA. Management of inherited thrombophilia. http://www.uptodate.com/home. Accessed June 6, ...

  13. New microbial growth factor

    Science.gov (United States)

    Bok, S. H.; Casida, L. E., Jr.

    1977-01-01

    A screening procedure was used to isolate from soil a Penicillium sp., two bacterial isolates, and a Streptomyces sp. that produced a previously unknown microbial growth factor. This factor was an absolute growth requirement for three soil bacteria. The Penicillium sp. and one of the bacteria requiring the factor, an Arthrobacter sp., were selected for more extensive study concerning the production and characteristics of the growth factor. It did not seem to be related to the siderochromes. It was not present in soil extract, rumen fluid, or any other medium component tested. It appears to be a glycoprotein of high molecular weight and has high specific activity. When added to the diets for a meadow-vole mammalian test system, it caused an increased consumption of diet without a concurrent increase in rate of weight gain.

  14. Factors Affecting Wound Healing

    Science.gov (United States)

    Guo, S.; DiPietro, L.A.

    2010-01-01

    Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds. PMID:20139336

  15. Factor X assay

    Science.gov (United States)

    ... D, Neff AT. Rare coagulation factor deficiencies. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, ... Laboratory evaluation of hemostatic and thrombotic disorders. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, ...

  16. Rheumatoid Factors: Clinical Applications

    Directory of Open Access Journals (Sweden)

    Francesca Ingegnoli

    2013-01-01

    Full Text Available Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects. Rheumatoid factors form part of the workup for the differential diagnosis of arthropathies. In clinical practice, it is recommended to measure anti-cyclic citrullinated peptide antibodies and rheumatoid factors together because anti-cyclic citrullinated peptide antibodies alone are only moderately sensitive, and the combination of the two markers improves diagnostic accuracy, especially in the case of early rheumatoid arthritis. Furthermore, different rheumatoid factor isotypes alone or in combination can be helpful when managing rheumatoid arthritis patients, from the time of diagnosis until deciding on the choice of therapeutic strategy.

  17. Heart Disease Risk Factors

    Science.gov (United States)

    ... Hearts® WISEWOMAN Program Other Chronic Disease Topics Diabetes Nutrition Obesity Physical Activity Stroke Heart Disease Risk Factors Recommend ... Hearts® WISEWOMAN Program Other Chronic Disease Topics Diabetes Nutrition Obesity Physical Activity Stroke File Formats Help: How do ...

  18. Human Factors Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose: The purpose of the Human Factors Laboratory is to further the understanding of highway user needs so that those needs can be incorporated in roadway design,...

  19. Factors Affecting Wound Healing

    OpenAIRE

    Guo, S.; DiPietro, L A

    2010-01-01

    Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutane...

  20. FGF growth factor analogs

    Science.gov (United States)

    Zamora, Paul O [Gaithersburg, MD; Pena, Louis A [Poquott, NY; Lin, Xinhua [Plainview, NY; Takahashi, Kazuyuki [Germantown, MD

    2012-07-24

    The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

  1. Brain derived neurotrophic factor

    DEFF Research Database (Denmark)

    Mitchelmore, Cathy; Gede, Lene

    2014-01-01

    Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies are curre......Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies...

  2. General Factors in Graphs.

    Science.gov (United States)

    1986-07-01

    conjectured that the general factor problem can be solved in polynomial time when, in each Bi, all the gaps (if any) have length one. We prove this conjecture...exactly bi edges incident with node i, for each i. This problem is well-solved. A polynomial algorithm is known (Edmonds and Johnson (1970)) as well as a...powerful theorem to characterize the existence of solutions ( Tutte (1952)). The following generalization of the factor problem was studied by Lovtsz

  3. Factors Impacting Knowledge Sharing

    DEFF Research Database (Denmark)

    Schulzmann, David; Slepniov, Dmitrij

    The purpose of this paper is to examine various factors affecting knowledge sharing at the R&D center of a Western MNE in China. The paper employs qualitative methodology and is based on the action research and case study research techniques. The findings of the paper advance our understanding...... about factors that affect knowledge sharing. The main emphasis is given to the discussion on how to improve knowledge sharing in global R&D organizations....

  4. Los factores de riesgo

    Directory of Open Access Journals (Sweden)

    Justo Senado Dumoy

    1999-01-01

    Full Text Available Sobre el fundamento filosófico de los conceptos de la Dialéctica Materialista, se presenta un análisis en relación con el concepto e interpretación de los Factores de Riesgo.A analysis on the concept and interpretation of risk factors is presented based on the philosophical foundation of the concepts of materialist dialectics.

  5. Factors affecting emotional divorce

    Directory of Open Access Journals (Sweden)

    Karim Said Shabanlou

    2016-03-01

    Full Text Available Emotional Divorce is the most important factor in the rupture of the most fundamental structures of society, the family.Due to the sensitivity and position of the familyAnd its functions specifically to investigate the factors underlying emotional divorce has of particular importance.Emotional Divorce phenomenon is not a single factor, but rather a set of related factors together led to Emotional Divorce.In this paper the role of psychological factors such as early maladaptive schemas, negative body image, perfectionism is discussed on an emotional divorce.Also quality of life and family relationships of couples with emotional divorce,Such as quality of health, sexual dissatisfaction, ignoring the needs, expectations and opinions of women by men or vice versa,And also social and economic factors such as subcultures families, couples, the quality of social relationships, social networks couple,Economic situation of the families of the couple, financial crisis, unemployment and economic revenues couples studied and some suggestions are presented based on the findings.

  6. CATTELL AND EYSENCK FACTOR SCORES RELATED TO COMREY PERSONALITY FACTORS.

    Science.gov (United States)

    Comrey, A L; Duffy, K E

    1968-10-01

    The Eysenck Personality Inventory, the Cattell 16 PF Inventory, and the Comrey Personality Inventory were administered to 272 volunteers. Eysenck and Cattell factor scores were correlated with scores over homogeneous item groups (FHIDs) which define the Comrey test factors. This matrix was factor analyzed to relate the Eysenck and Cattell factor scores to the factor structure underlying the Comrey test. The Eysenck Neuroticism, Comrey Neuroticism, and Cattell second-order Anxiety factors appeared to match. The Eysenck Introversion and the Comrey Shyness factors also matched. The 16 Cattell primary factors overlapped but did not match with the Comrey factors.

  7. Breast cancer risk factors

    Directory of Open Access Journals (Sweden)

    Marzena Kamińska

    2015-09-01

    Full Text Available Breast cancer is the most frequently diagnosed neoplastic disease in women around menopause often leading to a significant reduction of these women’s ability to function normally in everyday life. The increased breast cancer incidence observed in epidemiological studies in a group of women actively participating in social and professional life implicates the necessity of conducting multidirectional studies in order to identify risk factors associated with the occurrence of this type of neoplasm. Taking the possibility of influencing the neoplastic transformation process in individuals as a criterion, all the risk factors initiating the process can be divided into two groups. The first group would include inherent factors such as age, sex, race, genetic makeup promoting familial occurrence of the neoplastic disease or the occurrence of benign proliferative lesions of the mammary gland. They all constitute independent parameters and do not undergo simple modification in the course of an individual’s life. The second group would include extrinsic factors conditioned by lifestyle, diet or long-term medical intervention such as using oral hormonal contraceptives or hormonal replacement therapy and their influence on the neoplastic process may be modified to a certain degree. Identification of modifiable factors may contribute to development of prevention strategies decreasing breast cancer incidence.

  8. [Prognostic factors in resuscitation].

    Science.gov (United States)

    Bahloul, F; Le Gall, J R; Loirat, P; Alperovitch, A; Patois, E

    1988-10-08

    The outcome from intensive care is known to be influenced by such factors as age, previous health status, severity of the disease and diagnosis. In order to assess the influence of each individual factor, 3,687 patients from 38 French intensive care units were studied. For each patient were recorded: age, simplified acute physiological score (SAPS), previous health status, diagnosis, type of intensive care unit (medicine, scheduled or elective surgery) and immediate outcome. Each of these factors was found to influence the immediate survival rate. A multivariate analysis ranked the factors in the following order: SAPS, age, type of intensive care unit and previous health status. Diagnosis played a role in the prognosis since with a 10-15 points SAPS mortality was nil for drug overdose, 12 per cent for chronic obstructive pulmonary disease and 38 per cent for cardiogenic shock. However, a single diagnosis was made in only 37 per cent of the patients, as against 3 diagnoses in 17 per cent and 4 diagnoses or more in 7 per cent. When the type of intensive care unit was considered, the mean death rate was 20 per cent in medicine, 27 per cent in scheduled surgery and 5 per cent in elective surgery (P less than 0.001). Since this study showed a definite influence of each of the four factors on immediate survival, intensive care patients can be described and classified according to this system. However, it must be stressed that individual prognoses are extremely vague.

  9. Perspectivas Pedagogicas. Documentos-Ponencias Y Ensayos Proyecto Teacher Corps, Ciclo XII (Pedagogical Perspectives. Documents, Papers and Essays, Teacher Corps Project, Cycle XII).

    Science.gov (United States)

    Albino, Isidra, Ed.; Davila, Sonia, Ed.

    The purpose of this book is to stimulate ideas leading to a sharing of approaches, strategies, and methodologies applicable to the education of Puerto Ricans. Following introductory material, 18 papers are presented, the first 10 of which are in Spanish. Titles and authors are: (1) "El maestro que Puerto Rico necesita," Leonides Santos…

  10. Geothermal Plant Capacity Factors

    Energy Technology Data Exchange (ETDEWEB)

    Greg Mines; Jay Nathwani; Christopher Richard; Hillary Hanson; Rachel Wood

    2015-01-01

    The capacity factors recently provided by the Energy Information Administration (EIA) indicated this plant performance metric had declined for geothermal power plants since 2008. Though capacity factor is a term commonly used by geothermal stakeholders to express the ability of a plant to produce power, it is a term frequently misunderstood and in some instances incorrectly used. In this paper we discuss how this capacity factor is defined and utilized by the EIA, including discussion on the information that the EIA requests from operations in their 923 and 860 forms that are submitted both monthly and annually by geothermal operators. A discussion is also provided regarding the entities utilizing the information in the EIA reports, and how those entities can misinterpret the data being supplied by the operators. The intent of the paper is to inform the facility operators as the importance of the accuracy of the data that they provide, and the implications of not providing the correct information.

  11. Multi-factor authentication

    Energy Technology Data Exchange (ETDEWEB)

    Hamlet, Jason R; Pierson, Lyndon G

    2014-10-21

    Detection and deterrence of spoofing of user authentication may be achieved by including a cryptographic fingerprint unit within a hardware device for authenticating a user of the hardware device. The cryptographic fingerprint unit includes an internal physically unclonable function ("PUF") circuit disposed in or on the hardware device, which generates a PUF value. Combining logic is coupled to receive the PUF value, combines the PUF value with one or more other authentication factors to generate a multi-factor authentication value. A key generator is coupled to generate a private key and a public key based on the multi-factor authentication value while a decryptor is coupled to receive an authentication challenge posed to the hardware device and encrypted with the public key and coupled to output a response to the authentication challenge decrypted with the private key.

  12. The focus factor

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Frandsen, Tove Faber

    2015-01-01

    Introduction. We present a new bibliometric indicator to measure journal specialisation over time, named the focus factor. This new indicator is based on bibliographic coupling and counts the percentage of re-citations given in subsequent years. Method. The applicability of the new indicator....... To validate re-citations as caused by specialisation, other possible causes were measured and correlated (obsolescence, journal self-citations and number of references). Results. The results indicate that the focus factor is capable of distinguishing between general and specialised journals and thus...... effectively measures the intended phenomenon (i.e., journal specialisation). Only weak correlations were found between journal re-citations and obsolescence, journal self-citations, and number of references. Conclusions. The focus factor successfully measures journal specialisation over time. Measures based...

  13. La adolescencia: factores criticos

    Directory of Open Access Journals (Sweden)

    Noé Ardila Espinel

    1980-01-01

    Full Text Available Ten factors, tbat are considered by several psychologists as sensitive and characterístíc of the adolescent period, were tested by means of a Lykert type scale of 50 ítems, Seventy-eight subjects divided in three groups (U·13 years, early adolescence; 14·17 years, middle adolescence; 18-22 years, late adolescence answered the scale, Results índicate age differences. The factors that are in conflict duríng the middle adolescente are: emotional control, self control, social behavior, logical thinking, tendeney toward independency, economic índependency, family índependency, relígíous independency, rules conflict,and affective development, The factors change in direction before, during, and after adolescence

  14. Model Correction Factor Method

    DEFF Research Database (Denmark)

    Christensen, Claus; Randrup-Thomsen, Søren; Morsing Johannesen, Johannes

    1997-01-01

    The model correction factor method is proposed as an alternative to traditional polynomial based response surface techniques in structural reliability considering a computationally time consuming limit state procedure as a 'black box'. The class of polynomial functions is replaced by a limit...... statebased on an idealized mechanical model to be adapted to the original limit state by the model correction factor. Reliable approximations are obtained by iterative use of gradient information on the original limit state function analogously to previous response surface approaches. However, the strength...... of the model correction factor method, is that in simpler form not using gradient information on the original limit state function or only using this information once, a drastic reduction of the number of limit state evaluation is obtained together with good approximations on the reliability. Methods...

  15. Orthogonal factorizations of digraphs

    Institute of Scientific and Technical Information of China (English)

    Guizhen LIU

    2009-01-01

    Let G be a digraph with vertex set V(G) and arc set E(G) and let g = (g-,g+) and f = (f-, f+) be pairs of positive integer-valued functions defined on V(G) such that g-(x) ≤ f-(x) and g+(x) ≤ f+(x) for each x ∈ V(G). A (g, f)-factor of G is a spanning subdigraph H of G such that g-(x) ≤ idH(x) ≤ f-(x) and g+(x) ≤ odu(x) ≤ f+(x) for each x ∈ V(H); a (g, f)-factorization of G is a partition of E(G) into arc-disjoint (g, f)-factors. Let = {F1,F2,...,Fm} and H be a factorization and a subdigraph of G, respectively, is called k-orthogonal to H if each FI, 1 ≤ I ≤ m, has exactly k arcs in common with H. In this paper it is proved that every (mg+m-1, mf-m+1)-digraph has a (g, f)-factorization k-orthogonal to any given subdigraph with km arcs if k ≤ min{g-(x),g+(x)} for any x ∈ V(G) and that every (mg, mf)-digraph has a (g, f)-factorization orthogonal to any given directed m-star if 0 ≤ g(x) ≤ f(x) for any x ∈ V(G). The results in this paper are in some sense best possible.

  16. Factores de riesgo psicosocial

    OpenAIRE

    Fernández, Borja

    2012-01-01

    Tras un año de estudio de la Prevención de Riesgos Laborales he podido ir adquiriendo, todavía más, una clara concienciación sobre el estudio, supresión y mejora de los factores de riesgo que afectan a los trabajadores en la ejecución de su trabajo. Algo que es fácil de darse cuenta al entrar en profundidad en estas cuestiones, es de la escasa conciencia que tienen las organizaciones y los trabajadores sobre lo perjudiciales que pueden ser para su salud los factores de riesgo ergonómicos. ...

  17. Graph factors modulo k

    DEFF Research Database (Denmark)

    Thomassen, Carsten

    2014-01-01

    We prove a general result on graph factors modulo k . A special case says that, for each natural number k , every (12k−7)-edge-connected graph with an even number of vertices contains a spanning subgraph in which each vertex has degree congruent to k modulo 2k.......We prove a general result on graph factors modulo k . A special case says that, for each natural number k , every (12k−7)-edge-connected graph with an even number of vertices contains a spanning subgraph in which each vertex has degree congruent to k modulo 2k....

  18. Endodontic surgery prognostic factors.

    Science.gov (United States)

    Azarpazhooh, Amir; Shah, Prakesh S

    2011-01-01

    Medline, (PubMed) and the Cochrane databases together with hand searching of the following journals: Journal of Endodontics, International Endodontic Journal, Oral Surgery Oral Medicine Oral Pathology (name changed to Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics in 1995), Endodontics and Dental Traumatology (name changed to Dental Traumatology in 2001), Journal of Oral and Maxillofacial Surgery, and International Journal of Oral and Maxillofacial Surgery. Clinical studies evaluating apical surgery with placement of a root-end filling were included. Studies on apical surgery with orthograde root canal filling or about apicectomy alone without root-end filling were excluded, as were experimental and animal studies. Only studies with ≥ ten patients with a minimum six month follow-up period and clearly defined radiographic and clinical healing criteria, with healing reported for at least two categories of a specific prognostic factor were accepted. Studies reporting in English, German, French, Spanish, Italian, Portuguese and Scandinavian languages were included. All studies were assessed separately by two of the three authors, with disagreements resolved by discussion. Prognostic factors were divided into patient related, tooth-related or treatment-related factors. The reported percentages of healed teeth were pooled per category. The statistical method of Mantel-Haenszel was applied to estimate the odds ratios and their 95% confidence intervals. Homogeneity was assessed using Woolf's test. With regard to tooth-related factors, the following were identified as predictors of healing: absence of preoperative pain or signs, good density of the root canal filling and a periapical lesion size of ≤ 5 mm. With regard to treatment-related factors, teeth treated with the use of an endoscope tended to have higher healed rates than teeth treated without the use of an endoscope. Although the clinician may be able to control treatment

  19. STEREOTYPICAL FACTORS IN TOURISM

    Directory of Open Access Journals (Sweden)

    Cristina-Elena ALBU

    2013-06-01

    Full Text Available International tourism has grown rapidly nowdays, contributing to the growth of the global economy. The purpose of this essay is to identify and analyze stereotypical factors in the development of strategies concerning the offer for the tourism industry: the image of a tourist destination, brand, country of origin and customer behaviour. Documentary study was the research method used: representative articles were analysed, as recent as possible, to determine the factors mentioned above. Professionals in the industry of tourism need to understand cultural differences between tourists, as well as those of the host country, to be able to create tourist reception offers that live up to the standards expected by clients.

  20. The transcription factor encyclopedia.

    Science.gov (United States)

    Yusuf, Dimas; Butland, Stefanie L; Swanson, Magdalena I; Bolotin, Eugene; Ticoll, Amy; Cheung, Warren A; Zhang, Xiao Yu Cindy; Dickman, Christopher T D; Fulton, Debra L; Lim, Jonathan S; Schnabl, Jake M; Ramos, Oscar H P; Vasseur-Cognet, Mireille; de Leeuw, Charles N; Simpson, Elizabeth M; Ryffel, Gerhart U; Lam, Eric W-F; Kist, Ralf; Wilson, Miranda S C; Marco-Ferreres, Raquel; Brosens, Jan J; Beccari, Leonardo L; Bovolenta, Paola; Benayoun, Bérénice A; Monteiro, Lara J; Schwenen, Helma D C; Grontved, Lars; Wederell, Elizabeth; Mandrup, Susanne; Veitia, Reiner A; Chakravarthy, Harini; Hoodless, Pamela A; Mancarelli, M Michela; Torbett, Bruce E; Banham, Alison H; Reddy, Sekhar P; Cullum, Rebecca L; Liedtke, Michaela; Tschan, Mario P; Vaz, Michelle; Rizzino, Angie; Zannini, Mariastella; Frietze, Seth; Farnham, Peggy J; Eijkelenboom, Astrid; Brown, Philip J; Laperrière, David; Leprince, Dominique; de Cristofaro, Tiziana; Prince, Kelly L; Putker, Marrit; del Peso, Luis; Camenisch, Gieri; Wenger, Roland H; Mikula, Michal; Rozendaal, Marieke; Mader, Sylvie; Ostrowski, Jerzy; Rhodes, Simon J; Van Rechem, Capucine; Boulay, Gaylor; Olechnowicz, Sam W Z; Breslin, Mary B; Lan, Michael S; Nanan, Kyster K; Wegner, Michael; Hou, Juan; Mullen, Rachel D; Colvin, Stephanie C; Noy, Peter John; Webb, Carol F; Witek, Matthew E; Ferrell, Scott; Daniel, Juliet M; Park, Jason; Waldman, Scott A; Peet, Daniel J; Taggart, Michael; Jayaraman, Padma-Sheela; Karrich, Julien J; Blom, Bianca; Vesuna, Farhad; O'Geen, Henriette; Sun, Yunfu; Gronostajski, Richard M; Woodcroft, Mark W; Hough, Margaret R; Chen, Edwin; Europe-Finner, G Nicholas; Karolczak-Bayatti, Magdalena; Bailey, Jarrod; Hankinson, Oliver; Raman, Venu; LeBrun, David P; Biswal, Shyam; Harvey, Christopher J; DeBruyne, Jason P; Hogenesch, John B; Hevner, Robert F; Héligon, Christophe; Luo, Xin M; Blank, Marissa Cathleen; Millen, Kathleen Joyce; Sharlin, David S; Forrest, Douglas; Dahlman-Wright, Karin; Zhao, Chunyan; Mishima, Yuriko; Sinha, Satrajit; Chakrabarti, Rumela; Portales-Casamar, Elodie; Sladek, Frances M; Bradley, Philip H; Wasserman, Wyeth W

    2012-01-01

    Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130 mini review articles on pertinent human, mouse and rat TFs. Notable features of the TFe website include a high-quality PDF generator and web API for programmatic data retrieval. TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe.

  1. The Transcription Factor Encyclopedia

    DEFF Research Database (Denmark)

    Yusuf, Dimas; Butland, Stefanie L; Swanson, Magdalena I

    2012-01-01

    mini review articles on pertinent human, mouse and rat TFs. Notable features of the TFe website include a high-quality PDF generator and web API for programmatic data retrieval. TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written......ABSTRACT: Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130...

  2. Factors stimulating content marketing

    Directory of Open Access Journals (Sweden)

    Naser Azad

    2016-02-01

    Full Text Available This paper presents an empirical investigation to determine factors influencing on content marketing in banking industry. The study designs a questionnaire consists of 40 questions in Likert scale and distributes it among 550 randomly selected regular customers of Bank Mellat in city of Tehran, Iran and 400 properly filled questionnaires are collected. Cronbach alphas for all components of the survey are well above desirable level. Using principle component analysis with Varimax rotation, the study has determined six factors influencing the most on content marketing including organization, details, having new ideas, quality, sensitivity and power while the last component contains only two subcomponents and is removed from the study.

  3. Human factors in network security

    OpenAIRE

    Jones, Francis B.

    1991-01-01

    Human factors, such as ethics and education, are important factors in network information security. This thesis determines which human factors have significant influence on network security. Those factors are examined in relation to current security devices and procedures. Methods are introduced to evaluate security effectiveness by incorporating the appropriate human factors into network security controls

  4. Introduction to human factors

    Energy Technology Data Exchange (ETDEWEB)

    Winters, J.M.

    1988-03-01

    Some background is given on the field of human factors. The nature of problems with current human/computer interfaces is discussed, some costs are identified, ideal attributes of graceful system interfaces are outlined, and some reasons are indicated why it's not easy to fix the problems. (LEW)

  5. Irrational factor races

    Indian Academy of Sciences (India)

    Sneha Chaubey; Milenda Lanius; Alexandru Zaharescu

    2014-11-01

    We investigate the behavior of the sum of the irrational factor function over arithmetic progressions. We first establish a general asymptotic formula for such a sum, and then obtain some further results in the case of arithmetic progressions 3 ± 1.

  6. Affective Factors: Anxiety

    Science.gov (United States)

    Tasnimi, Mahshad

    2009-01-01

    Affective factors seem to play a crucial role in success or failure in second language acquisition. Negative attitudes can reduce learners' motivation and harm language learning, while positive attitudes can do the reverse. Discovering students' attitudes about language will help both teacher and student in teaching learning process. Anxiety is…

  7. Hyperglycemia: a prothrombotic factor?

    NARCIS (Netherlands)

    B.A. Lemkes; J. Hermanides; J.H. Devries; F. Holleman; J.C.M. Meijers; J.B.L. Hoekstra

    2010-01-01

    Diabetes mellitus is characterized by a high risk of atherothrombotic events. What is more, venous thrombosis has also been found to occur more frequently in this patient group. This prothrombotic condition in diabetes is underpinned by laboratory findings of elevated coagulation factors and impaire

  8. FRUIT NUTRITIVE FACTOR NETWORK

    Institute of Scientific and Technical Information of China (English)

    Yanqing QU; Yumei JIANG; Daren HE

    2009-01-01

    As an research example of the widely existing cooperation-competition systems, the authors present an empirical investigation on a fruit nutritive factor network. It is described by a node-weighted bipartite graph. The fruit nutritive factors are defined as the nodes, and two nodes are connected by an edge if at least one fruit contains these two nutritive factors. The fruits are defined as the collaboration acts. The node-weight Writ, which signifies the "importance degree" of each actor node, is defined as the content of a nutritive factor in a fruit. The empirical investigation results show some unique features.The node-weight distributions take so-called "shifted power law" function forms, but the act-weight distribution takes a normal form. The degree and act-degree distributions show impulsive-spectrum like forms. These observations may be helpful for the study of fruits. The network description method proposed in this article may be universal for a kind of cooperation-competition systems.

  9. Environmental factors and leukaemia

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, L.

    1985-01-01

    Investigations on the association between environmental hazards and the development of various types of leukaemia are reviewed. Regarding acute non-lymphocytic leukaemia (ANLL) exposure to ionizing radiation is a well-documented risk factor. According to several recent studies exposure to strong electromagnetic fields may be suspected to be of etiologic importance for ANLL. There is evidence that occupational handling of benzene is a risk factor and other organic solvents may also be leukaemogenic. Occupational exposure to petrol products has been proposed to be a risk factor although the hazardous substances have not yet been defined. Results of cytogenetic studies in ANLL suggest that exposure to certain environmental agents may be associated with relatively specific clonal chromosome aberrations. Exposure in utero to ionizing radiation has been proposed to be a risk factor for acute lymphocytic leukaemia (ALL) in children. Unlike ANLL there seems at present to be little evidence that ALL is related to exposure to some chemicals. Chronic myeloid leukaemia (CML) may follow exposure to high doses of ionizing radiation whereas such exposure seems to be of insignificant importance for the development of chronic lymphocytic leukaemia (CLL). According to some studies an abnormally high incidence of CLL may be found among farmers in the USA. These results have not been confirmed in Scandinavian studies. There seems to be little evidence that CML or CLL are related to occupational handling of some chemicals. 35 references.

  10. Factor Analysis and AIC.

    Science.gov (United States)

    Akaike, Hirotugu

    1987-01-01

    The Akaike Information Criterion (AIC) was introduced to extend the method of maximum likelihood to the multimodel situation. Use of the AIC in factor analysis is interesting when it is viewed as the choice of a Bayesian model; thus, wider applications of AIC are possible. (Author/GDC)

  11. eta ' transition form factors

    NARCIS (Netherlands)

    Amo Sanchez, del P.; Raven, H.G.; Snoek, H.; BaBar, Collaboration

    2011-01-01

    eta((')) transition form factors in the momentum-transfer range from 4 to 40 GeV(2). The analysis is based on 469 fb(-1) of integrated luminosity collected at PEP-II with the BABAR detector at e(+)e(-) center-of-mass energies near 10.6 GeV.

  12. Identificar Factores de Riesgo

    Directory of Open Access Journals (Sweden)

    Luis Carlos Silva Ayçaguer

    2005-01-01

    Full Text Available Se exponen el contexto histórico y las condiciones en que se ha configurado lo que podría caracterizarse como una verdadera "cacería de factores de riesgo" en la epidemiología contemporánea. Entre otros problemas, se ha extendido la práctica de encarar el problema de la determinación o identificación de factores de riesgo a través de un ritual estadístico que roza la caricatura y, lo más importante, que la mayor parte de las veces no conduce a conseguir el objetivo de la investigación, ni a obtener nuevos conocimientos. El trabajo caracteriza dicho ritual y examina críticamente sus pasos. Se realiza una detallada discusión de la endeblez metodológica de tal procedimiento y se ilustra profusamente su empleo.

  13. Smad transcription factors.

    Science.gov (United States)

    Massagué, Joan; Seoane, Joan; Wotton, David

    2005-12-01

    Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology-the transforming growth factor-beta (TGFbeta) pathway. Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes. A rich repertoire of regulatory devices exerts control over each step of the Smad pathway. This knowledge is enabling work on more complex questions about the organization, integration, and modulation of Smad-dependent transcriptional programs. We are beginning to uncover self-enabled gene response cascades, graded Smad response mechanisms, and Smad-dependent synexpression groups. Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior.

  14. Precipitating factors of asthma.

    Science.gov (United States)

    Lee, T H

    1992-01-01

    Asthma is characterised by bronchial hyperresponsiveness. This feature of the asthmatic diathesis predisposes patients to wheezing in response to a number of different factors. These precipitating factors include specific allergen acting via sensitised mediator cells through an IgE-dependent mechanism. There are irritants which may work through a non-specific manner, or stimuli such as exercise and hyperventilation, which probably also act through mediator release via a non-IgE-dependent manner. The mechanism whereby physical stimuli such as exercise induce bronchoconstriction is of interest, because it increases the context in which the mast cell may participate in acute asthmatic bronchoconstriction. Respiratory infections also commonly provoke asthma, especially in infants and may, indeed, precipitate the asthmatic state itself. Finally, drugs can often trigger asthma attacks and the mechanisms of asthma precipitated by non-steroidal anti-inflammatory drugs such as aspirin have been the subject of recent research.

  15. Helicopter human factors

    Science.gov (United States)

    Hart, Sandra G.

    1988-01-01

    The state-of-the-art helicopter and its pilot are examined using the tools of human-factors analysis. The significant role of human error in helicopter accidents is discussed; the history of human-factors research on helicopters is briefly traced; the typical flight tasks are described; and the noise, vibration, and temperature conditions typical of modern military helicopters are characterized. Also considered are helicopter controls, cockpit instruments and displays, and the impact of cockpit design on pilot workload. Particular attention is given to possible advanced-technology improvements, such as control stabilization and augmentation, FBW and fly-by-light systems, multifunction displays, night-vision goggles, pilot night-vision systems, night-vision displays with superimposed symbols, target acquisition and designation systems, and aural displays. Diagrams, drawings, and photographs are provided.

  16. [Streptococcus pyogenes pathogenic factors].

    Science.gov (United States)

    Bidet, Ph; Bonacorsi, S

    2014-11-01

    The pathogenicity of ß-hemolytic group A streptococcus (GAS) is particularly diverse, ranging from mild infections, such as pharyngitis or impetigo, to potentially debilitating poststreptococcal diseases, and up to severe invasive infections such as necrotizing fasciitis or the dreaded streptococcal toxic shock syndrome. This variety of clinical expressions, often radically different in individuals infected with the same strain, results from a complex interaction between the bacterial virulence factors, the mode of infection and the immune system of the host. Advances in comparative genomics have led to a better understanding of how, following this confrontation, GAS adapts to the immune system's pressure, either peacefully by reducing the expression of certain virulence factors to achieve an asymptomatic carriage, or on the contrary, by overexpressing them disproportionately, resulting in the most severe forms of invasive infection.

  17. Power factor compensation

    Energy Technology Data Exchange (ETDEWEB)

    Barra R, Felipe [Schneider Electric Chile (Chile)

    2010-07-01

    Every company is looking for ways to increase productivity as a way to gain a competitive advantage. Energy is a significant element in making any product and so it is important to assess production processes from an energy perspective. This paper discusses the impact of power factor compensation on energy efficiency. The life cycle solution for energy efficiency involves optimization of active energy using automation and regulation. A brief explanation is given of how each component of a company plays a part in this cycle. Examples include simulations and analysis, modeling, performance monitoring facilities, and environmental sustainability. Reactive energy suppliers and the installation of capacitors are also explained. Types of compensation include fixed and automation compensations. Economic advantages include a reduction in the electricity bill and active energy consumption. Technical advantages include reduction in voltage drop and an increase in available power. The power correction factor also improves reliability and contributes to conservation of the environment.

  18. On braid monodromy factorizations

    Energy Technology Data Exchange (ETDEWEB)

    Kharlamov, V M [Institut de Recherche Matematique Avanee Universite Louis Pasteur et CNRS 7 rue Rene Descartes (France); Kulikov, Vik S [Steklov Mathematical Institute, Russian Academy of Sciences (Russian Federation)

    2003-06-30

    We introduce and develop a language of semigroups over the braid groups to study the braid monodromy factorizations (bmf's) of plane algebraic curves and other related objects. As an application, we give a new proof of Orevkov's theorem on the realization of bmf's over a disc by algebraic curves and show that the complexity of such a realization cannot be bounded in terms of the types of factors of the bmf. We also prove that the type of a bmf distinguishes Hurwitz curves with singularities of inseparable type up to H-isotopy and J-holomorphic cuspidal curves in CP{sup 2} up to symplectic isotopy.

  19. The focus factor

    DEFF Research Database (Denmark)

    Nicolaisen, Jeppe; Frandsen, Tove Faber

    2015-01-01

    is demonstrated on a selection of general science journals and on a selection of medical journals. The reference lists of each journal are compared year by year, and the percentage of re-citations is calculated by dividing the number of re-citations with the total number of citations each year. Analysis......Introduction. We present a new bibliometric indicator to measure journal specialisation over time, named the focus factor. This new indicator is based on bibliographic coupling and counts the percentage of re-citations given in subsequent years. Method. The applicability of the new indicator....... To validate re-citations as caused by specialisation, other possible causes were measured and correlated (obsolescence, journal self-citations and number of references). Results. The results indicate that the focus factor is capable of distinguishing between general and specialised journals and thus...

  20. Cross-culturally recurrent personality factors : Analyses of three factors

    NARCIS (Netherlands)

    De Raad, B; Peabody, D

    2005-01-01

    This study proceeds from an earlier one that examined the 'Big Five' factors (Peabody & De Raad, 2002). That study considered the substantive nature of five factors from six European psycholexical studies. The results supported Big Five Factor III (Conscientiousness), but Factors I (Extraversion) an

  1. Information security factors systematization

    OpenAIRE

    Янченко, Вадим Николавевич; Ивченко, Александр Владимирович; Залога, Вильям Александрович; Дынник, Оксана Дмитриевна

    2015-01-01

    In this article the necessity of solving the theoretical and practical task, aimed on development the methodological basis for elaboration and implementation of information security management system, has been considered. Based on research results of scientific works and the requirements in the field of information security management the universal multilevel system of information security factors of organizations (enterprises) in the wood properties form was offered by using quality control ...

  2. La lapidación como castigo de las relaciones sexuales no legales (zinā en el seno de la escuela Mālikí: doctrina, práctica legal y actitudes individuales frente al delito (ss. XI y XII

    Directory of Open Access Journals (Sweden)

    Serrano Ruano, Delfina

    2005-12-01

    Full Text Available The Maliki jurist Ibn Rushd al-Jadd (d.520/1126 issued a fatwā regarding stoning as a punishment for zinā (unlawful sexual relations. This article examines this fatwā, focusing on three problems: 1 the scarcity of references to implementation of stoning as a punishment for zinā in the pre-modem period, 2 the generally contradictory attitude of pre-modem Muslim jurists, who stressed the validity of stoning as a punishment for zinā but also called for a strict observance of the law, a factor that made it almost impossible to implement, and 3 the importance of the legal opinions offered by pre-modern fuqahā' with regard to contemporary discussions on stoning.

    Partiendo del análisis de una fetua en la que se plantea la posibilidad de condenar a la lapidación a una mujer acusada de haber mantenido relaciones sexuales ilícitas con un hombre, se analiza la doctrina legal sobre zinā de Ibn Rušd el abuelo (m. 520/1126, uno de los juristas mālikíes más relevantes de todos los tiempos. El análisis de esta doctrina conduce a una reflexión acerca de tres cuestiones: 1 la escasez de referencias a la aplicación del castigo de lapidación en el período pre-moderno, 2 la actitud contradictoria de los juristas musulmanes de ese mismo período, los cuales, por una parte sostienen la vigencia del castigo y por otra parte insisten en el respeto escrupuloso de una doctrina que hace que sea prácticamente imposible aplicarlo y 3 la vigencia del corpus de opiniones creado por estos juristas en los debates contemporáneos acerca de la práctica de la lapidación.

  3. The malingering factor.

    Science.gov (United States)

    Williams, J Michael

    2011-04-01

    The influence of malingering and suboptimal performance on neuropsychological tests has become a major interest of clinical neuropsychologists. Methods to detect malingering have focused on specialized tests or embedded patterns associated with malingering present in the conventional neuropsychology tests. There are two stages to the study of their validity. The first stage involves whether the method can discriminate malingering subjects from those who are not malingering. In the second stage, they must be examined for their relationship to the conventional tests used to establish impairment and disability. Constantinou, Bauer, Ashendorf, Fisher, and McCaffrey (2005. Is poor performance on recognition memory effort measures indicative of generalized poor performance on neuropsychological tests? Archives of Clinical Neuropsychology, 20, 191-198.) conducted the only study in which correlations are presented between a commonly used symptom validity test, the Test of Memory Malingering (TOMM) and the subtests of the Wechsler Adult Intelligence Scale-Revised (WAIS-R). A factor analysis was conducted using these correlations. It revealed a clear malingering factor that explained significant variance in the TOMM and the WAIS-R subtests. The relationship of malingering with cognitive tests is complex: some tests are sensitive to malingering and others are not. Factor analysis can summarize the magnitude of variance associated with each test and reveal the patterns of inter-relationships between malingering and clinical tests. The analysis also suggested that malingering assessment methods could be improved by the addition of timing the responses.

  4. Risk Factors for Cholelithiasis.

    Science.gov (United States)

    Pak, Mila; Lindseth, Glenda

    2016-01-01

    Gallstone disease is one of the most common public health problems in the United States. Approximately 10%-20% of the national adult populations currently carry gallstones, and gallstone prevalence is rising. In addition, nearly 750,000 cholecystectomies are performed annually in the United States; direct and indirect costs of gallbladder surgery are estimated to be $6.5 billion. Cholelithiasis is also strongly associated with gallbladder, pancreatic, and colorectal cancer occurrence. Moreover, the National Institutes of Health estimates that almost 3,000 deaths (0.12% of all deaths) per year are attributed to complications of cholelithiasis and gallbladder disease. Although extensive research has tried to identify risk factors for cholelithiasis, several studies indicate that definitive findings still remain elusive. In this review, predisposing factors for cholelithiasis are identified, the pathophysiology of gallstone disease is described, and nonsurgical preventive options are discussed. Understanding the risk factors for cholelithiasis may not only be useful in assisting nurses to provide resources and education for patients who are diagnosed with gallstones, but also in developing novel preventive measures for the disease.

  5. Nucleon Electromagnetic Form Factors

    Energy Technology Data Exchange (ETDEWEB)

    Kees de Jager

    2004-08-01

    Although nucleons account for nearly all the visible mass in the universe, they have a complicated structure that is still incompletely understood. The first indication that nucleons have an internal structure, was the measurement of the proton magnetic moment by Frisch and Stern (1933) which revealed a large deviation from the value expected for a point-like Dirac particle. The investigation of the spatial structure of the nucleon, resulting in the first quantitative measurement of the proton charge radius, was initiated by the HEPL (Stanford) experiments in the 1950s, for which Hofstadter was awarded the 1961 Nobel prize. The first indication of a non-zero neutron charge distribution was obtained by scattering thermal neutrons off atomic electrons. The recent revival of its experimental study through the operational implementation of novel instrumentation has instigated a strong theoretical interest. Nucleon electro-magnetic form factors (EMFFs) are optimally studied through the exchange of a virtual photon, in elastic electron-nucleon scattering. The momentum transferred to the nucleon by the virtual photon can be selected to probe different scales of the nucleon, from integral properties such as the charge radius to scaling properties of its internal constituents. Polarization instrumentation, polarized beams and targets, and the measurement of the polarization of the recoiling nucleon have been essential in the accurate separation of the charge and magnetic form factors and in studies of the elusive neutron charge form factor.

  6. Human Factors Review Plan

    Energy Technology Data Exchange (ETDEWEB)

    Paramore, B.; Peterson, L.R. (eds.)

    1985-12-01

    ''Human Factors'' is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management.

  7. Accidents - personal factors

    Energy Technology Data Exchange (ETDEWEB)

    Zaitsev, S.L.; Tsygankov, A.V.

    1982-03-01

    This paper evaluates influence of selected personal factors on accident rate in underground coal mines in the USSR. Investigations show that so-called organizational factors cause from 80 to 85% of all accidents. About 70% of the organizational factors is associated with social, personal and economic features of personnel. Selected results of the investigations carried out in Donbass mines are discussed. Causes of miner dissatisfaction are reviewed: 14% is caused by unsatisfactory working conditions, 21% by repeated machine failures, 16% by forced labor during days off, 14% by unsatisfactory material supply, 16% by hard physical labor, 19% by other reasons. About 25% of miners injured during work accidents are characterized as highly professionally qualified with automatic reactions, and about 41% by medium qualifications. About 60% of accidents is caused by miners with less than a 3 year period of service. About 15% of accidents occurs during the first month after a miner has returned from a leave. More than 30% of accidents occurs on the first work day after a day or days off. Distribution of accidents is also presented: 19% of accidents occurs during the first 2 hours of a shift, 36% from the second to the fourth hour, and 45% occurs after the fourth hour and before the shift ends.

  8. Molecular factors in migraine

    Science.gov (United States)

    Kowalska, Marta; Prendecki, Michał; Kozubski, Wojciech; Lianeri, Margarita; Dorszewska, Jolanta

    2016-01-01

    Migraine is a common neurological disorder that affects 11% of adults worldwide. This disease most likely has a neurovascular origin. Migraine with aura (MA) and more common form - migraine without aura (MO) – are the two main clinical subtypes of disease. The exact pathomechanism of migraine is still unknown, but it is thought that both genetic and environmental factors are involved in this pathological process. The first genetic studies of migraine were focused on the rare subtype of MA: familial hemiplegic migraine (FHM). The genes analysed in familial and sporadic migraine are: MTHFR, KCNK18, HCRTR1, SLC6A4, STX1A, GRIA1 and GRIA3. It is possible that migraine is a multifactorial disease with polygenic influence. Recent studies have shown that the pathomechanisms of migraine involves both factors responsible for immune response and oxidative stress such as: cytokines, tyrosine metabolism, homocysteine; and factors associated with pain transmission and emotions e.g.: serotonin, hypocretin-1, calcitonin gene-related peptide, glutamate. The correlations between genetic variants of the HCRTR1 gene, the polymorphism 5-HTTLPR and hypocretin-1, and serotonin were observed. It is known that serotonin inhibits the activity of hypocretin neurons and may affect the appearance of the aura during migraine attack. The understanding of the molecular mechanisms of migraine, including genotype-phenotype correlations, may contribute to finding markers important for the diagnosis and treatment of this disease. PMID:27191890

  9. Perinatal risk factors for strabismus

    DEFF Research Database (Denmark)

    Torp-Pedersen, Tobias; Boyd, Heather A; Poulsen, Gry;

    2010-01-01

    Little is known about the aetiological factors underlying strabismus. We undertook a large cohort study to investigate perinatal risk factors for strabismus, overall and by subtype.......Little is known about the aetiological factors underlying strabismus. We undertook a large cohort study to investigate perinatal risk factors for strabismus, overall and by subtype....

  10. Contact factor proteases and the complexes formed with alpha 2-macroglobulin can interfere in protein C assays by cleaving amidolytic substrates.

    Science.gov (United States)

    Mackie, I J; Gallimore, M; Machin, S J

    1992-10-01

    Plasma from women taking combined oral contraceptives and cold-activated plasma contain proteases which cleave chromogenic substrates in protein C assays in the absence of protein C activators such as Protac. This spontaneous activity makes a background substraction necessary and makes protein C (PC) assays less accurate. We investigated two commonly used substrates PKK)-deficient plasmas led to cleavage of chromogenic substrate for protein C. The protein C substrates were cleaved by purified kallikrein and alpha- and beta-FXIIa. Immunoabsorption with alpha 2-macroglobulin (alpha 2M) antibodies removed 60% of the alpha 2M and 70% of the activity on PC Substrate. Gel filtration of normal plasma on Sephadex G-150 gave a single peak of protein C activity and antigen in the included volume. After cold activation of the fractions, a second protein C-like peak appeared in the void volume, but with no detectable protein C antigen. This peak coincided with alpha 2M (chromogenic and ELISA) and plasma kallikrein (S-2302), but FXII (measured with a substrate insensitive to kallikrein) eluted separately.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. Milestones and Impact Factors

    Directory of Open Access Journals (Sweden)

    Grandjean Philippe

    2010-07-01

    Full Text Available Abstract Environmental Health has just received its first Impact Factor by Thomson ISI. At a level of 2.48, this achievement is quite satisfactory and places Environmental Health in the top 25% of environmental science journals. When the journal was launched in 2002, it was still unclear whether the Open Access publishing model could be made into a viable commercial enterprise within the biomedical field. During the past eight years, Open Access journals have become widely available, although still covering only about 15% of journal titles. Major funding agencies and institutions, including prominent US universities, now require that researchers publish in Open Access journals. Because of the profound role of scientific journals for the sharing of results and communication between researchers, the advent of Open Access may be of as much significance as the transition from handwriting to printing via moveable type. As Environmental Health is an electronic Open Access journal, the numbers of downloads at the journal website can be retrieved. The top-20 list of articles most frequently accessed shows that all of them have been downloaded over 10,000 times. Back in 2002, the first article published was accessed only 49 times during the following month. A year later, the server had over 1,000 downloads per month, and now the total number of monthly downloads approaches 50,000. These statistics complement the Impact Factor and confirm the viability of Open Access in our field of research. The advent of digital media and its decentralized mode of distribution - the internet - have dramatically changed the control and financing of scientific information dissemination, while facilitating peer review, accelerating editorial handling, and supporting much needed transparency. Both the meaning and means of "having an impact" are therefore changing, as will the degree and way in which scientific journals remain "factors" in that impact.

  12. Milestones and impact factors.

    Science.gov (United States)

    Ozonoff, David M; Grandjean, Philippe

    2010-07-08

    Environmental Health has just received its first Impact Factor by Thomson ISI. At a level of 2.48, this achievement is quite satisfactory and places Environmental Health in the top 25% of environmental science journals. When the journal was launched in 2002, it was still unclear whether the Open Access publishing model could be made into a viable commercial enterprise within the biomedical field. During the past eight years, Open Access journals have become widely available, although still covering only about 15% of journal titles. Major funding agencies and institutions, including prominent US universities, now require that researchers publish in Open Access journals. Because of the profound role of scientific journals for the sharing of results and communication between researchers, the advent of Open Access may be of as much significance as the transition from handwriting to printing via moveable type. As Environmental Health is an electronic Open Access journal, the numbers of downloads at the journal website can be retrieved. The top-20 list of articles most frequently accessed shows that all of them have been downloaded over 10,000 times. Back in 2002, the first article published was accessed only 49 times during the following month. A year later, the server had over 1,000 downloads per month, and now the total number of monthly downloads approaches 50,000. These statistics complement the Impact Factor and confirm the viability of Open Access in our field of research. The advent of digital media and its decentralized mode of distribution - the internet - have dramatically changed the control and financing of scientific information dissemination, while facilitating peer review, accelerating editorial handling, and supporting much needed transparency. Both the meaning and means of "having an impact" are therefore changing, as will the degree and way in which scientific journals remain "factors" in that impact.

  13. A New Factorization Method to Factorize RSA Public Key Encryption

    Directory of Open Access Journals (Sweden)

    Bhagvant Ram Ambedkar

    2011-11-01

    Full Text Available The security of public key encryption such as RSA scheme relied on the integer factoring problem. The security of RSA algorithm is based on positive integer N, because each transmitting node generates pair of keys such as public and private. Encryption and decryption of any message depends on N. Where, N is the product of two prime numbers and pair of key generation is dependent on these prime numbers. The factorization of N is very intricate. In this paper a New Factorization method is proposed to obtain the factor of positive integer N. The proposed work focuses on factorization of all trivial and nontrivial integer numbers and requires fewer steps for factorization process of RSA modulus N. The New Factorization method is based on Pollard rho factorization method. Experimental results shown that factorization speed is fast as compare existing methods.

  14. Cultural Factors in Reading

    Institute of Scientific and Technical Information of China (English)

    孔敏

    2005-01-01

    Reading is a basic ability in learning English and reading comprehension exercise is a common way to assess this ability.Since reading is a communicative activity between author and reader in written form,there are some different rules and regulations of this communication in different countries.Therefore,cultural factors,existing in reading,decide,help,and influence the percentage of the right answers.This article attempts to analyze the effects of cultural differences in reading and the barriers in comprehension,and aims to improve students awareness of cultural differences in reading.

  15. Human Factors Model

    Science.gov (United States)

    1993-01-01

    Jack is an advanced human factors software package that provides a three dimensional model for predicting how a human will interact with a given system or environment. It can be used for a broad range of computer-aided design applications. Jack was developed by the computer Graphics Research Laboratory of the University of Pennsylvania with assistance from NASA's Johnson Space Center, Ames Research Center and the Army. It is the University's first commercial product. Jack is still used for academic purposes at the University of Pennsylvania. Commercial rights were given to Transom Technologies, Inc.

  16. Auxin response factors.

    Science.gov (United States)

    Chandler, John William

    2016-05-01

    Auxin signalling involves the activation or repression of gene expression by a class of auxin response factor (ARF) proteins that bind to auxin response elements in auxin-responsive gene promoters. The release of ARF repression in the presence of auxin by the degradation of their cognate auxin/indole-3-acetic acid repressors forms a paradigm of transcriptional response to auxin. However, this mechanism only applies to activating ARFs, and further layers of complexity of ARF function and regulation are being revealed, which partly reflect their highly modular domain structure. This review summarizes our knowledge concerning ARF binding site specificity, homodimer and heterodimer multimeric ARF association and cooperative function and how activator ARFs activate target genes via chromatin remodelling and evolutionary information derived from phylogenetic comparisons from ARFs from diverse species. ARFs are regulated in diverse ways, and their importance in non-auxin-regulated pathways is becoming evident. They are also embedded within higher-order transcription factor complexes that integrate signalling pathways from other hormones and in response to the environment. The ways in which new information concerning ARFs on many levels is causing a revision of existing paradigms of auxin response are discussed.

  17. Robust and Sparse Factor Modelling

    DEFF Research Database (Denmark)

    Croux, Christophe; Exterkate, Peter

    Factor construction methods are widely used to summarize a large panel of variables by means of a relatively small number of representative factors. We propose a novel factor construction procedure that enjoys the properties of robustness to outliers and of sparsity; that is, having relatively few...... nonzero factor loadings. Compared to the traditional factor construction method, we find that this procedure leads to a favorable forecasting performance in the presence of outliers and to better interpretable factors. We investigate the performance of the method in a Monte Carlo experiment...

  18. Eukaryotic transcription factors

    DEFF Research Database (Denmark)

    Staby, Lasse; O'Shea, Charlotte; Willemoës, Martin

    2017-01-01

    Gene-specific transcription factors (TFs) are key regulatory components of signaling pathways, controlling, for example, cell growth, development, and stress responses. Their biological functions are determined by their molecular structures, as exemplified by their structured DNA-binding domains...... targeting specific cis-acting elements in genes, and by the significant lack of fixed tertiary structure in their extensive intrinsically disordered regions. Recent research in protein intrinsic disorder (ID) has changed our understanding of transcriptional activation domains from 'negative noodles' to ID...... them to participate in large interactomes, how they use only a few hydrophobic residues, short sequence motifs, prestructured motifs, and coupled folding and binding for their interactions with co-activators, and how their accessibility to post-translational modification affects their interactions...

  19. Pion form factor

    Energy Technology Data Exchange (ETDEWEB)

    Ryong Ji, C.; Pang, A.; Szczepaniak, A. [North Carolina State Univ., Raleigh, NC (United States)

    1994-04-01

    It is pointed out that the correct criterion to define the legal PQCD contribution to the exclusive processes in the lightcone perturbative expansion should be based on the large off-shellness of the lightcone energy in the intermediate states. In the lightcone perturbative QCD calculation of the pion form factor, the authors find that the legal PQCD contribution defined by the lightcone energy cut saturates in the smaller Q{sup 2} region compared to that defined by the gluon four-momentum square cut. This is due to the contribution by the highly off-energy-shell gluons in the end point regions of the phase space, indicating that the gluon four-momentum-square cut may have cut too much to define the legal PQCD.

  20. Unity power factor converter

    Science.gov (United States)

    Wester, Gene W. (Inventor)

    1980-01-01

    A unity power factor converter capable of effecting either inversion (dc-to-dc) or rectification (ac-to-dc), and capable of providing bilateral power control from a DC source (or load) through an AC transmission line to a DC load (or source) for power flow in either direction, is comprised of comparators for comparing the AC current i with an AC signal i.sub.ref (or its phase inversion) derived from the AC ports to generate control signals to operate a switch control circuit for high speed switching to shape the AC current waveform to a sine waveform, and synchronize it in phase and frequency with the AC voltage at the AC ports, by selectively switching the connections to a series inductor as required to increase or decrease the current i.

  1. Asma: factores precipitantes

    OpenAIRE

    Pimenta, José Eduardo da Silva Maia Ferreira

    2009-01-01

    A asma é uma doença pulmonar crónica caracterizada por obstrução das vias aéreas, inflamação e hiperreactividade brônquica. A asma afecta cerca de 150 milhões de pessoas de todas as idades no Mundo. Em Portugal calcula-se que atinja cerca de 600.000 pessoas incluindo crianças e adultos, calculando-se que afecte cerca de 11% das crianças e 5% dos adultos. A asma é uma doença que provavelmente resulta de uma interacção complexa entre múltiplos factores ambientais e influências...

  2. Psychosomatic factors in pruritus.

    Science.gov (United States)

    Tey, Hong Liang; Wallengren, Joanna; Yosipovitch, Gil

    2013-01-01

    Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association. Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus. Management of chronic pruritus is directed at treating the underlying causes and adopting a multidisciplinary approach to address the dermatologic, somatosensory, cognitive, and emotional aspects. Pharmcotherapeutic agents that are useful for chronic pruritus with comorbid depression and/or anxiety comprise selective serotonin reuptake inhibitors, mirtazapine, tricyclic antidepressants (amitriptyline and doxepin), and anticonvulsants (gabapentin, pregabalin); the role of neurokinin receptor-1 antagonists awaits verification. Antipsychotics are required for treating itch and formication associated with schizophrenia and delusion of parasitosis (including Morgellons disease). Copyright © 2013 Elsevier Inc. All rights reserved.

  3. Nucleon Electromagnetic Form Factors

    Energy Technology Data Exchange (ETDEWEB)

    Marc Vanderhaeghen; Charles Perdrisat; Vina Punjabi

    2007-10-01

    There has been much activity in the measurement of the elastic electromagnetic proton and neutron form factors in the last decade, and the quality of the data has greatly improved by performing double polarization experiments, in comparison with previous unpolarized data. Here we review the experimental data base in view of the new results for the proton, and neutron, obtained at JLab, MAMI, and MIT-Bates. The rapid evolution of phenomenological models triggered by these high-precision experiments will be discussed, including the recent progress in the determination of the valence quark generalized parton distributions of the nucleon, as well as the steady rate of improvements made in the lattice QCD calculations.

  4. Tiled QR factorization algorithms

    CERN Document Server

    Bouwmeester, Henricus; Langou, Julien; Robert, Yves

    2011-01-01

    This work revisits existing algorithms for the QR factorization of rectangular matrices composed of p-by-q tiles, where p >= q. Within this framework, we study the critical paths and performance of algorithms such as Sameh and Kuck, Modi and Clarke, Greedy, and those found within PLASMA. Although neither Modi and Clarke nor Greedy is optimal, both are shown to be asymptotically optimal for all matrices of size p = q^2 f(q), where f is any function such that \\lim_{+\\infty} f= 0. This novel and important complexity result applies to all matrices where p and q are proportional, p = \\lambda q, with \\lambda >= 1, thereby encompassing many important situations in practice (least squares). We provide an extensive set of experiments that show the superiority of the new algorithms for tall matrices.

  5. Milestones and impact factors

    DEFF Research Database (Denmark)

    Ozonoff, David M; Grandjean, Philippe

    2010-01-01

    universities, now require that researchers publish in Open Access journals. Because of the profound role of scientific journals for the sharing of results and communication between researchers, the advent of Open Access may be of as much significance as the transition from handwriting to printing via moveable...... type. As Environmental Health is an electronic Open Access journal, the numbers of downloads at the journal website can be retrieved. The top-20 list of articles most frequently accessed shows that all of them have been downloaded over 10,000 times. Back in 2002, the first article published...... was accessed only 49 times during the following month. A year later, the server had over 1,000 downloads per month, and now the total number of monthly downloads approaches 50,000. These statistics complement the Impact Factor and confirm the viability of Open Access in our field of research. The advent...

  6. Helicopter Human Factors

    Science.gov (United States)

    Hart, Sandra G.; Sridhar, Banavar (Technical Monitor)

    1995-01-01

    Even under optimal conditions, helicopter flight is a most demanding form of human-machine interaction, imposing continuous manual, visual, communications, and mental demands on pilots. It is made even more challenging by small margins for error created by the close proximity of terrain in NOE flight and missions flown at night and in low visibility. Although technology advances have satisfied some current and proposed requirements, hardware solutions alone are not sufficient to ensure acceptable system performance and pilot workload. However, human factors data needed to improve the design and use of helicopters lag behind advances in sensor, display, and control technology. Thus, it is difficult for designers to consider human capabilities and limitations when making design decisions. This results in costly accidents, design mistakes, unrealistic mission requirements, excessive training costs, and challenge human adaptability. NASA, in collaboration with DOD, industry, and academia, has initiated a program of research to develop scientific data bases and design principles to improve the pilot/vehicle interface, optimize training time and cost, and maintain pilot workload and system performance at an acceptable level. Work performed at Ames, and by other research laboratories, will be reviewed to summarize the most critical helicopter human factors problems and the results of research that has been performed to: (1) Quantify/model pilots use of visual cues for vehicle control; (2) Improve pilots' performance with helmet displays of thermal imagery and night vision goggles for situation awareness and vehicle control; (3) Model the processes by which pilots encode maps and compare them to the visual scene to develop perceptually and cognitively compatible electronic map formats; (4) Evaluate the use of spatially localized auditory displays for geographical orientation, target localization, radio frequency separation; (5) Develop and flight test control

  7. Helicopter Human Factors

    Science.gov (United States)

    Hart, Sandra G.; Sridhar, Banavar (Technical Monitor)

    1995-01-01

    Even under optimal conditions, helicopter flight is a most demanding form of human-machine interaction, imposing continuous manual, visual, communications, and mental demands on pilots. It is made even more challenging by small margins for error created by the close proximity of terrain in NOE flight and missions flown at night and in low visibility. Although technology advances have satisfied some current and proposed requirements, hardware solutions alone are not sufficient to ensure acceptable system performance and pilot workload. However, human factors data needed to improve the design and use of helicopters lag behind advances in sensor, display, and control technology. Thus, it is difficult for designers to consider human capabilities and limitations when making design decisions. This results in costly accidents, design mistakes, unrealistic mission requirements, excessive training costs, and challenge human adaptability. NASA, in collaboration with DOD, industry, and academia, has initiated a program of research to develop scientific data bases and design principles to improve the pilot/vehicle interface, optimize training time and cost, and maintain pilot workload and system performance at an acceptable level. Work performed at Ames, and by other research laboratories, will be reviewed to summarize the most critical helicopter human factors problems and the results of research that has been performed to: (1) Quantify/model pilots use of visual cues for vehicle control; (2) Improve pilots' performance with helmet displays of thermal imagery and night vision goggles for situation awareness and vehicle control; (3) Model the processes by which pilots encode maps and compare them to the visual scene to develop perceptually and cognitively compatible electronic map formats; (4) Evaluate the use of spatially localized auditory displays for geographical orientation, target localization, radio frequency separation; (5) Develop and flight test control

  8. Factor Rotation and Standard Errors in Exploratory Factor Analysis

    Science.gov (United States)

    Zhang, Guangjian; Preacher, Kristopher J.

    2015-01-01

    In this article, we report a surprising phenomenon: Oblique CF-varimax and oblique CF-quartimax rotation produced similar point estimates for rotated factor loadings and factor correlations but different standard error estimates in an empirical example. Influences of factor rotation on asymptotic standard errors are investigated using a numerical…

  9. ADJUSTMENT FACTORS AND ADJUSTMENT STRUCTURE

    Institute of Scientific and Technical Information of China (English)

    Tao Benzao

    2003-01-01

    In this paper, adjustment factors J and R put forward by professor Zhou Jiangwen are introduced and the nature of the adjustment factors and their role in evaluating adjustment structure is discussed and proved.

  10. EAMJ Risk Factors 10.indd

    African Journals Online (AJOL)

    2010-02-02

    Feb 2, 2010 ... Several factors have been suggested as independent risk factors for their ... Conclusions: Current standard regimens in resource-limited countries are associated .... Summary of outcomes and fate of all the ADRs:The most.

  11. R-Factor for Alaska

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The rainfall-runoff erosivity factor (R-Factor) quantifies the effects of raindrop impacts and reflects the amount and rate of runoff associated with the rain. The...

  12. FACTORING TO FIT OFF DIAGONALS.

    Science.gov (United States)

    imply an upper bound on the number of factors. When applied to somatotype data, the method improved substantially on centroid solutions and indicated a reinterpretation of earlier factoring studies. (Author)

  13. Factores de crecimiento IV: Factor de crecimiento epidérmico,Factores estimuladores de colonias, Neurotropinas Growth factors: epidermal growth factor, colony stimulating factors and neurotropins

    Directory of Open Access Journals (Sweden)

    Hilda Norha Jaramillo Londoño

    1999-02-01

    Full Text Available En esta cuarta entrega sobre los factores de crecimiento se revisan el factor de crecimiento epidérmico (EGF, los factores estimuladores de colonias (CSF y las neurotropinas. Como se ha venido presentando en las anteriores entregas, se hace referencia a su estructura bioquímica, su mecanismo de acción, sus efectos biológicos y sus interacciones. Las neurotropinas y el EGF, por tratarse de factores que actúan predominantemente en el microambiente tisular, no pueden manejarse en el contexto de concentraciones circulantes, situación que sí es factible para los CSF. De otro lado, se revisan los mecanismos de las neurotropinas en el sistema nervioso. In this fourth review of growth factors we summarize, as in previous papers, topics related to biochemical structure, mechanisms of action, biological effects and cross-interactions for epidermal growth factor (EGF, colony stimulating factors (CSF and neurotropins. Since the effects of EGF and neurotropins are exerted predominantly at the microenvironment level, they can not be evaluated by means of its circulating levels, a fact that could be possible for CSFs.

  14. Plasma factor XIII and platelet factor XIII in hyperlipaemia.

    Science.gov (United States)

    Cucuianu, M P; Miloszewski, K; Porutiu, D; Losowsky, M S

    1976-12-31

    Plasma factor XIII activity measured by a quantitative assay was found to be significantly higher in hypertriglyceridaemic patients (type IV and combined hyperlipoproteinaemia), as compared to normolipaemic controls. No such elevation in plasma factor XIII activity was found in patients with type Ha hyperlipaemia. Plasma pseudocholinesterase was found to parallel the elevated factor XIII activity in hypertriglyceridaemic subjects. In contrast, platelet factor XIII activity was not raised in hyperlipaemic subjects, and plasma factor XIII was found to be normal in a normolipaemic subjects with thrombocythaemia. It was concluded that there is no significant contribution from platelets to plasma factor XIII activity, and that the observed increase in plasma factor XIII in hypertriglyceridaemia results from enhanced hepatic synthesis of the enzyme.

  15. Human Factors in Marine Casualties

    Directory of Open Access Journals (Sweden)

    Jelenko Švetak

    2002-05-01

    Full Text Available Human factors play an important role in the origin of accidents,and it is commonly claimed that between seventy andninety-five percent of industrial and transport accidents involvehuman factors, see Figure 1.Some authorities, however, claim that ultimately, all accidentsinvolve human factors.

  16. Investing in systematic factor premiums

    NARCIS (Netherlands)

    Koedijk, Kees G.; Slager, Alfred M. H.; Stork, P.A.

    2016-01-01

    In this paper we investigate and evaluate factor investing in the US and Europe for equities and bonds. We show that factor-based portfolios generally produce comparable or better portfolios than market indices. We expand the analysis to other asset classes and factors, work with other optimisation

  17. Factors Affecting Children Learning English

    Institute of Scientific and Technical Information of China (English)

    李楠

    2002-01-01

    By reviewing the literature, the author points out some theoretical defects of the CPH on which the policy was based. CPH is the conceptualization formulation of the maturational constraints for SLA. The paper, based on the reality of China, put forward some suggestion, which includes the time factor, the teacher's factor and the content factor.

  18. Phonological Awareness: Factors of Influence

    Science.gov (United States)

    Frohlich, Linda Paulina; Petermann, Franz; Metz, Dorothee

    2013-01-01

    Early child development is influenced by various genetic and environmental factors. This study aims to identify factors that affect the phonological awareness of preschool and first grade children. Based on a sample of 330 German-speaking children (mean age = 6.2 years) the following domains were evaluated: Parent factors, birth and pregnancy,…

  19. Social networks and factor markets

    DEFF Research Database (Denmark)

    Abay, Kibrom Araya; Kahsay, Goytom Abraha; Berhane, Guush

    In the absence of well-established factor markets, the role of indigenous institutions and social networks can be substantial for mobilizing factors for agricultural production. We investigate the role of an indigenous social network in Ethiopia, the iddir, in facilitating factor market...

  20. Factor Analysis of Intern Effectiveness

    Science.gov (United States)

    Womack, Sid T.; Hannah, Shellie Louise; Bell, Columbus David

    2012-01-01

    Four factors in teaching intern effectiveness, as measured by a Praxis III-similar instrument, were found among observational data of teaching interns during the 2010 spring semester. Those factors were lesson planning, teacher/student reflection, fairness & safe environment, and professionalism/efficacy. This factor analysis was as much of a…

  1. Factor analysis and missing data

    NARCIS (Netherlands)

    Kamakura, WA; Wedel, M

    2000-01-01

    The authors study the estimation of factor models and the imputation of missing data and propose an approach that provides direct estimates of factor weights without the replacement of missing data with imputed values. First, the approach is useful in applications of factor analysis in the presence

  2. Risks factoring business: accounting measurement

    Directory of Open Access Journals (Sweden)

    Z.V. Gutsaylyuk

    2015-06-01

    Full Text Available The paper carried out the identification of risk factors for the development of possible accounting software management. Studied theoretical and methodological aspects of the risk classification of factoring operations in the part of the risk assessment factors. It is proposed to consider the risks factors as the risk that is acceptable controlled by accounting instruments and the risks that can not be taken into account in the accounting records. To minimize the risk factor, accounting-driven tools, a method of self-insurance, which is a factor in the creation of provision for factoring transactions designed to cover unexpected expenses and losses. Provision for factoring factor will establish more stable conditions of financial activity and avoid the fluctuations of profit factor in relation to the writing off of losses on factoring operatsіyam.Developed proposals allow for further research to improve the organizational and methodological basis of accounting and analysis of information as a basis for providing risk management factor, particularly in terms of improving the evaluation questions such risks and their qualitative and quantitative analysis.

  3. Human Factors in Training

    Science.gov (United States)

    Barshi, Immanuel; Byrne, Vicky; Arsintescu, Lucia; Connell, Erin

    2010-01-01

    Future space missions will be significantly longer than current shuttle missions and new systems will be more complex than current systems. Increasing communication delays between crews and Earth-based support means that astronauts need to be prepared to handle the unexpected on their own. As crews become more autonomous, their potential span of control and required expertise must grow to match their autonomy. It is not possible to train for every eventuality ahead of time on the ground, or to maintain trained skills across long intervals of disuse. To adequately prepare NASA personnel for these challenges, new training approaches, methodologies, and tools are required. This research project aims at developing these training capabilities. By researching established training principles, examining future needs, and by using current practices in space flight training as test beds, both in Flight Controller and Crew Medical domains, this research project is mitigating program risks and generating templates and requirements to meet future training needs. Training efforts in Fiscal Year 09 (FY09) strongly focused on crew medical training, but also began exploring how Space Flight Resource Management training for Mission Operations Directorate (MOD) Flight Controllers could be integrated with systems training for optimal Mission Control Center (MCC) operations. The Training Task addresses Program risks that lie at the intersection of the following three risks identified by the Project: 1) Risk associated with poor task design; 2) Risk of error due to inadequate information; and 3) Risk associated with reduced safety and efficiency due to poor human factors design.

  4. Proteolytic factors in exosomes.

    Science.gov (United States)

    Shimoda, Masayuki; Khokha, Rama

    2013-05-01

    Exosomes are small microvesicles secreted from the late endosomal compartment of cells. Although an increasing body of evidence indicates that they play a pivotal role in cell-to-cell communication, the biological functions of exosomes are far from fully understood. Recent work has revealed detailed proteomic profiles of exosomes from cell lines and body fluids, which may provide clues to understanding their biological significance and general importance in human diseases. Metalloproteinases include the cell surface-anchored sheddases a disintegrin and metalloproteinases, as well as cell surface-bound and soluble matrix metalloproteinases and these extracellular proteases have been detected in exosomes by proteomic analyses. Exosomes play a key role in the transfer of proteins to other cells and metalloproteinases may provide a novel platform where ectodomain shedding by these membrane proteases alters the makeup of the recipient cell's surface. This review aims to address some of the facets of exosome biology with particular emphasis on the proteolytic factors and we discuss their potential involvement in human diseases, especially tumor biology.

  5. PANCHROMATIC HUBBLE ANDROMEDA TREASURY. XII. MAPPING STELLAR METALLICITY DISTRIBUTIONS IN M31

    Energy Technology Data Exchange (ETDEWEB)

    Gregersen, Dylan; Seth, Anil C. [Department of Physics and Astronomy, University of Utah, Salt Lake City, UT 84112 (United States); Williams, Benjamin F.; Dalcanton, Julianne J.; Johnson, L. C.; Lewis, Alexia R. [Department of Astronomy, Box 351580, University of Washington, Seattle, WA 98195 (United States); Lang, Dustin [McWilliams Center for Cosmology, Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213 (United States); Girardi, Leó [Osservatorio Astronomico di Padova—INAF, Vicolo dell’Osservatori 5, I-35122 Padova (Italy); Skillman, Evan D. [Minnesota Institute for Astrophysics, University of Minnesota, Minneapolis, MN 55455 (United States); Bell, Eric [Department of Astronomy, University of Michigan, 500 Church Street, Ann Arbor, MI 48109 (United States); Dolphin, Andrew E. [Raytheon, 1151 E. Hermans Road, Tucson, AZ 85706 (United States); Fouesneau, Morgan [MPIA, Koenigstuhl 17, D-69117 Heidelberg (Germany); Guhathakurta, Puragra; Hamren, Katherine M. [UCO/Lick Observatory, University of California at Santa Cruz, 1156 High Street, Santa Cruz, CA 95064 (United States); Kalirai, Jason [Department of Physics and Astronomy, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218 (United States); Monachesi, Antonela [MPA, Garching (Germany); Olsen, Knut, E-mail: dylan.gregersen@utah.edu, E-mail: aseth@astro.utah.edu [NOAO, Tucson, AZ 85719 (United States)

    2015-12-15

    We present a study of spatial variations in the metallicity of old red giant branch stars in the Andromeda galaxy. Photometric metallicity estimates are derived by interpolating isochrones for over seven million stars in the Panchromatic Hubble Andromeda Treasury (PHAT) survey. This is the first systematic study of stellar metallicities over the inner 20 kpc of Andromeda’s galactic disk. We see a clear metallicity gradient of −0.020 ± 0.004 dex kpc{sup −1} from ∼4–20 kpc assuming a constant red giant branch age. This metallicity gradient is derived after correcting for the effects of photometric bias and completeness and dust extinction, and is quite insensitive to these effects. The unknown age gradient in M31's disk creates the dominant systematic uncertainty in our derived metallicity gradient. However, spectroscopic analyses of galaxies similar to M31 show that they typically have small age gradients that make this systematic error comparable to the 1σ error on our metallicity gradient measurement. In addition to the metallicity gradient, we observe an asymmetric local enhancement in metallicity at radii of 3–6 kpc that appears to be associated with Andromeda’s elongated bar. This same region also appears to have an enhanced stellar density and velocity dispersion.

  6. Panchromatic Hubble Andromeda Treasury XII. Mapping Stellar Metallicity Distributions in M31

    CERN Document Server

    Gregersen, Dylan; Williams, Benjamin F; Lang, Dustin; Dalcanton, Julianne J; Girardi, Léo; Skillman, Evan D; Bell, Eric; Dolphin, Andrew E; Fouesneau, Morgan; Guhathakurta, Puragra; Hamren, Katherine M; Johnson, L C; Kalirai, Jason; Lewis, Alexia R; Monachesi, Antonela; Olsen, Knut

    2015-01-01

    We present a study of spatial variations in the metallicity of old red giant branch stars in the Andromeda galaxy. Photometric metallicity estimates are derived by interpolating isochrones for over seven million stars in the Panchromatic Hubble Andromeda Treasury (PHAT) survey. This is the first systematic study of stellar metallicities over the inner 20 kpc of Andromeda's galactic disk. We see a clear metallicity gradient of $-0.020\\pm0.004$ dex/kpc from $\\sim4-20$ kpc assuming a constant RGB age. This metallicity gradient is derived after correcting for the effects of photometric bias and completeness and dust extinction and is quite insensitive to these effects. The unknown age gradient in M31's disk creates the dominant systematic uncertainty in our derived metallicity gradient. However, spectroscopic analyses of galaxies similar to M31 show that they typically have small age gradients that make this systematic error comparable to the 1$\\sigma$ error on our metallicity gradient measurement. In addition to...

  7. Anamnesis de una estructura. La Catedral de Vitoria entre los siglos XII y XX

    Directory of Open Access Journals (Sweden)

    Cámara Muñoz, Leandro

    2002-12-01

    Full Text Available The Cathedral of Vitoria is a building with an extended historical life. We have attempted to produce a chronological sequence of the interventions and architectural “projects” since the beginning of the construction of the church on the early 13th century to the last restorations during the 1960s. This study attempts to fill a void on the available information, crucial for the evaluation of safety and durability issues on the Cathedral. The “anamnesis” practiced on the monument is one of the cornerstones of the method we have chosen for restoration, not only regarding the structural aspects, but regarding the problems of functional interpretation and symbolic content as well. This historical reading the key of structural analysis is what we intend to present: the extraction of the historical building sequence that leads to the current situation of the building, discriminating the different moments of the architectural project, phases of building growth and repair interventions on the structure that comment on or contradict among themselves, to result in the form that we witness now. We use that sequence to evaluate, albeit partially, the safety status of the structure, and to build a working hypothesis for the structural aspects of the restoration tasks.La Catedral de Vitoria es un edificio con una larga vida histórica, llena de acontecimientos constructivos que han venido interesando su comportamiento como estructura construida. Ha sido un objetivo primordial del Plan Director evaluar las sucesivas consecuencias de todos esos acontecimientos y explicar su concatenación. Todo ello se ha investigado durante su redacción, consiguiendo una secuencia cronológica en la que se relaciona el conjunto de intervenciones y de "proyectos" arquitectónicos que se suceden desde el comienzo de la construcción de la iglesia en los inicios del siglo XIII hasta sus últimas restauraciones en los años 60 del siglo XX. Este estudio histórico tiene una aplicación directa en la interpretación de los problemas estructurales que presenta el edificio y viene a llenar un vacío de información fundamental para la evaluación de la seguridad y perdurabilidad actuales de la Catedral. Esa historia de la Catedral viene a ser la recuperación del "historial médico" de un enfermo y puede dar muchas claves sobre los problemas estructurales que en otros apartados del mismo se detallan. La "anamnesis" practicada sobre el monumento es una de las "piedras de toque" del método elegido por nosotros para la restauración del conjunto catedralicio, no sólo en el tema estructural que interesa en esta ponencia sino en todos los problemas de interpretación funcional y contenido simbólico a los que hay que dar solución con las propuestas del restauración. La lectura de esa historia constructiva en clave de análisis estructural es lo que en esta ponencia se presenta: la extracción de la secuencia histórica constructiva que conduce al estado actual del edificio, discriminando los distintos momentos de proyecto arquitectónico, fases de crecimiento constructivo del edificio e intervenciones de reparación de la estructura que se explican o contradicen unos a otros para dar como resultado la torturada forma arquitectónica que nos encontramos ahora. A partir de esa secuencia se evalúa, en parte, el estado de seguridad remanente de la estructura, y se hace una hipótesis de trabajo para las tareas de restauración en esos aspectos estructurales.

  8. 5. XII algusega kell 18.30 peetakse Tallinna Linnateatris kunstisalong Allee kunstioksjon

    Index Scriptorium Estoniae

    2003-01-01

    Oksjonil on 40 teost 35 autorilt. 1. detsembrist saab oksjonivalikuga tutvuda kunstisalongis Allee. Enampakkumisel on K. A. Senffi, E. von Gebhardti, O. Hoffmanni, M. Dückeri, A. Audova, A. Johani, E. Kõksi, N. Mei, L. Mikko, R. Sagritsa, E. Timbermanni, R. Uutmaa, A. Vardi, E. Wiiralti, J. Greenbergi, A. Janseni, K. Mäe, R. Nymani, Ü. Soosteri jt. tööd.

  9. Research Linking Teacher Preparation and Student Performance: Teacher Education Yearbook XII

    Science.gov (United States)

    Guyton, Edith M., Ed.; Dangel, Julie Rainer, Ed.

    2004-01-01

    The case studies, research, and projects presented here strike at the very heart of effective teaching. The specific practices to improve student performance will spark classroom discussion and improve teacher practice. After a foreword by Frances van Tassell and an introduction by Edith M. Guyton and Julie Rainer Dangel, this book is divided into…

  10. The ACS Virgo Cluster Survey. XII. The Luminosity Function of Globular Clusters in Early Type Galaxies

    CERN Document Server

    Jordan, A; Côté, P; Ferrarese, L; Peng, E W; Mei, S; Villegas, D; Merritt, D; Tonry, J L; West, M J; Jordan, Andres; Laughlin, Dean E. Mc; Cote, Patrick; Ferrarese, Laura; Peng, Eric W.; Mei, Simona; Villegas, Daniela; Merritt, David; Tonry, John L.; West, Michael J.

    2007-01-01

    We analyze the luminosity function of the globular clusters (GCs) belonging to the early-type galaxies observed in the ACS Virgo Cluster Survey. We have obtained estimates for a Gaussian representation of the GC luminosity function (GCLF) for 89 galaxies. We have also fit the GCLFs with an "evolved Schechter function", which is meant to reflect the preferential depletion of low-mass GCs, primarily by evaporation due to two-body relaxation, from an initial Schechter mass function similar to that of young massive clusters. We find a significant trend of the GCLF dispersion with galaxy luminosity, in the sense that smaller galaxies have narrower GCLFs. We show that this narrowing of the GCLF in a Gaussian description is driven by a steepening of the GC mass function above the turnover mass, as one moves to smaller host galaxies. We argue that this behavior at the high-mass end of the GC mass function is most likely a consequence of systematic variations of the initial cluster mass function. The GCLF turnover mas...

  11. Chemotaxonomical researches in higher plants XII. Researches concerning the pigments and glucides of Phytolacca Americana L.

    Directory of Open Access Journals (Sweden)

    Gavrila NEAMTU

    1979-08-01

    Full Text Available The paper presents the results of biochemical analyses of Phytolacca Americana plants grown in the Agrobotanical Garden Cluj-Napoca. Carotenoid pigments (neoxanthin, violaxanthin, zeaxanthin, lutein, cryptoxanthin, alpha-carotene and beta-carotene chlorophyll pigments (a,b and glycoside pigments (betalaines, quercetin have been analysed in fruits and leaves respectively.

  12. 18. XII kell 12 kaitstakse EKA E-meedia keskuses 4 magistritööd...

    Index Scriptorium Estoniae

    2002-01-01

    Kristel Sibul "Kehatud kehad - kehad ja identiteet internetis" (juh. Katrin Kivimaa), Ivika Kivi "Virtuaalsed õpitarkvarad" (juh. Mare Emmott Tralla), Maris Lindoja "Digitaalne ruum" (juh. Andres Kurg), Raul Keller "Corporate Consulting in the Digital Age - Jamming vith the Culture" (juh. Richard Barbrook)

  13. Stereochemical studies of acyclic isoprenoids-XII. Lipids of methanogenic bacteria and possible contributions to sediments

    Science.gov (United States)

    Risatti, J.B.; Rowland, S.J.; Yon, D.A.; Maxwell, J.R.

    1984-01-01

    Abundant volatile lipids of Methanobacterium thermoautotrophicum and Methanosarcina barkeri include isoprenoid hydrocarbons (??? C30), and C15, C20 and C25 isoprenoid alcohols. M. barkeri contains 2,6,10,15,19-pentamethyleicosane, whose relative stereochemistry is the same as found in marine sediments, indicating that it is a marker of methanogenic activity. The C20, C30 and C25 alkenes in M. thermoautotrophicum also have a preferred sterochemistry; the latter have the 2,6,10,14,18-pentamethyleicosanyl skeleton, suggesting that the alkane in marine sediments may derive from methanogens. The stereochemistry of squalane in a marine sediment is also compatible with an origin in methanogens; in contrast, the stereochemistry of pristane in M. thermoautotrophicum indicates a fossil fuel contaminant origin, suggesting that this and certain other alkanes reported in archaebacteria might also be of contaminant origin. There is, therefore, little evidence at present that the pristane in immature marine sediments originates in methanogens. The C15 and C20 saturated alcohols in M. thermoautotrophicum have mainly the all-R configuration. If this is generally true for methanogens, the C20 alcohol in the Messel shale may originate mainly from methanogens, whereas that in the Green River shale may originate mainly from photosynthetic organisms. ?? 1984.

  14. Apuntes de los Ambía: linaje y parentelas (siglos XII-XVI

    Directory of Open Access Journals (Sweden)

    Otero Piñeyro Maseda, Pablo S.

    2009-12-01

    Full Text Available Documentary and heraldry news about the Ambia’s Galician lineage, one of the stocks constituting the heterogeneous social group of the Galician medieval knights and squires, are gathered in these pages. The need to know the patrimony, affiliation, tribes, heraldic signs and biographical data of that oligarchy classes is the consequence of their political relevance. As a result, it will be possible to conveniently placing and better understanding them in their historical context.

    En estas páginas se tratan de reunir las noticias documentales del linaje gallego de los Ambía, una de las estirpes que conforman el heterogéneo grupo social de los caballeros y escuderos medievales gallegos. De la relevancia de esos grupos oligárquicos deriva la necesidad de conocer sus patrimonios, filiaciones, parentelas, manifestaciones heráldicas y trayectoria vital, para situarlos convenientemente en su contexto histórico y comprenderlo mejor.

  15. Planck intermediate results. XII: Diffuse Galactic components in the Gould Belt System

    DEFF Research Database (Denmark)

    Planck Collaboration,; Ade, P. A. R.; Aghanim, N.

    2013-01-01

    We perform an analysis of the diffuse low-frequency Galactic components in the Southern part of the Gould Belt system (130^\\circ\\leq l\\leq 230^\\circ and -50^\\circ\\leq b\\leq -10^\\circ). Strong ultra-violet (UV) flux coming from the Gould Belt super-association is responsible for bright diffuse...... separate diffuse free-free emission and AME from synchrotron emission and thermal dust emission by using Planck data, complemented by ancillary data, using the "Correlated Component Analysis" (CCA) component separation method and we compare with the results of cross-correlation of foreground templates...

  16. Ultrasound imaging for the rheumatologist XII. Ultrasound imaging in sports medicine.

    Science.gov (United States)

    Filippucci, E; Meenagh, G; Delle Sedie, A; Riente, L; Iagnocco, A; Bombardieri, S; Valesini, G; Grassi, W

    2007-01-01

    The present review discusses the most frequent sport-related conditions which can present to rheumatologists and the available evidence base for using ultrasonography (US) in such scenarios. From a rheumatological perspective, sports-related pathology is mainly characterised by sub-acute and chronic overuse and stress-related disorders involving tendons, ligaments, muscles, joints and entheses. Major acute injuries are less frequently assessed in a standard rheumatological setting.Longitudinal studies are required to determine the clinical importance of US findings in athletes, particularly those who are asymptomatic. US findings need to be correlated with standard references including surgical and magnetic resonance imaging assessments. Future research should also be directed at determining the usefulness of power Doppler technique in monitoring sport-related abnormalities.

  17. Planck early results. XII. Cluster Sunyaev-Zeldovich optical scaling relations

    DEFF Research Database (Denmark)

    Bucher, M.; Delabrouille, J.; Giraud-Héraud, Y.

    2011-01-01

    We present the Sunyaev-Zeldovich (SZ) signal-to-richness scaling relation (Y500 - N200) for the MaxBCG cluster catalogue. Employing a multi-frequency matched filter on the Planck sky maps, we measure the SZ signal for each cluster by adapting the filter according to weak-lensing calibrated mass-r...

  18. National Training Course. Emergency Medical Technician. Paramedic. Instructor's Lesson Plans. Module XII. Pediatrics and Neonatal.

    Science.gov (United States)

    National Highway Traffic Safety Administration (DOT), Washington, DC.

    This instructor's lesson plan guide on pediatrics and neonatal transport is one of fifteen modules designed for use in the training of emergency medical technicians (paramedics). Five units of study are presented: (1) approach to the pediatric patient including patient assessment; (2) pathophysiology and management of problems unique to the…

  19. Estudiantes y profesores españoles en universidades extranjeras. Siglos XII-XVI

    Directory of Open Access Journals (Sweden)

    Bernabé BARTOLOMÉ MARTÍNEZ

    2010-03-01

    Full Text Available RESUMEN: Dentro de la línea histórico-comparada de este número de la revista, este trabajo pretende ser una elaboración de síntesis. Es un intento de encontrar unidad a algunas investigaciones dispersas que se van publicando sobre el tema. Los cartularios que existen de algunas universidades extranjeras son insuficientes y los libros de registros de estudiantes o de grados no nos han llegado apenas desde las alturas de aquellos siglos xn-xvi. Sin embargo una intensa indagación en los archivos municipales y catedralicios podría arrojar, para este caso, los datos suficientes.

  20. La Arquitectura de Ladrillo en la Provincia de Segovia, siglos XII Y XIII

    OpenAIRE

    Ruiz Hernando, José Antonio

    1988-01-01

    Desde hace mucho tiempo Antonio Ruiz Hernando tiene como ocupación primordial la de enseñar Historia del Arte en la Escuela de Arquitectura de Madrid. La dedicación y rigor que pone en esta tarea trasciende del espacio y del tiempo donde enseña y convierte su vida en un ejercicio, mezcla de conocimiento y emoción por el arte y su historia. Su ¡aborde investigación callada y seguida nos va ofreciendo con la periodicidad que en cada caso, precisa, aspectos y hechos desconocidos, que van ensambl...

  1. XII Encuentro Científico “Desarrollo, innovación y salud”

    Directory of Open Access Journals (Sweden)

    Luis Alberto Gómez

    2011-08-01

    Se prevé un aumento del doble o más en la incidencia y prevalencia de las cardiopatías isquémicas, los accidentes cerebro-vasculares y la diabetes en América Latina y el Caribe; también está aumentando la mortalidad por cáncer del pulmón, de mama y de próstata. Las enfermedades crónicas afectan de distinta manera a los hombres y a las mujeres; los grupos raciales minoritarios y los pobres suelen verse afectados con mayor frecuencia. Los costos anuales de las enfermedades crónicas son enormes; por ejemplo, para la diabetes, se estima que los costos ascendieron a más de US$ 65.000 millones en América Latina y el Caribe por año durante la última década. Por lo tanto, los retos que debe afrontar Colombia en la investigación en salud son muchos, tanto en enfermedades transmisibles y no transmisibles existentes, como en las amenazas al medio ambiente, los desastres naturales y los provocados por el hombre, las amenazas nuevas y emergentes de agentes infecciosos conocidos y desconocidos que pueden llegar a ser epidémicos y pandémicos. Estas amenazas constituyen un reto adicional que debe ser abordado desde diferentes enfoques de la investigación científica en salud, además de ser enfrentados de manera multidisciplinaria y multisectorial de acuerdo con las diferentes competencias de los grupos y las instituciones. La investigación en salud tiene una dinámica de interacción con diferentes disciplinas. La continuidad de los aportes y las futuras aplicaciones de estas investigaciones dependen, en gran parte, de los avances de la investigación en diferentes áreas, de su uso y de la apropiación social del conocimiento. Por ejemplo, los estudios clínicos y epidemiológicos, tanto descriptivos como analíticos, se enriquecen de los mecanismos biológicos y moleculares, contribuyendo a evaluar la relevancia y la relación causa-efecto en estudios de poblaciones. Es así como, las investigaciones en salud desde diferentes enfoques disciplinarios, son componentes complementarios de la totalidad de las evidencias que permiten entender los determinantes de un estado de salud o de enfermedad. Los progresos en la definición de la relación de un evento biológico, ambiental, nutricional o social con el riesgo de desarrollar una enfermedad, están orientados por los desarrollos científicos y tecnológicos, así como por su incorporación en los bienes y servicios. En este escenario tan complejo, y para enfrentar los problemas actuales y por venir, la investigación científica en salud es una de las áreas de desarrollo con una gran responsabilidad de generar conocimiento

  2. Planck early results. XII. Cluster Sunyaev-Zeldovich optical scaling relations

    DEFF Research Database (Denmark)

    Bucher, M.; Delabrouille, J.; Giraud-Héraud, Y.;

    2011-01-01

    -richness relations (N200 - M500). We bin our individual measurements and detect the SZ signal down to the lowest richness systems (N200 = 10) with high significance, achieving a detection of the SZ signal in systems with mass as low as M500 ≈ 5 × 1013 M. The observed Y500 - N200 relation is well modeled by a power...

  3. Planck intermediate results. XII: Diffuse Galactic components in the Gould Belt System

    CERN Document Server

    Ade, P A R; Alves, M I R; Arnaud, M; Ashdown, M; Atrio-Barandela, F; Aumont, J; Baccigalupi, C; Banday, A J; Barreiro, R B; Bartlett, J G; Battaner, E; Bedini, L; Benabed, K; Benoît, A; Bernard, J -P; Bersanelli, M; Bonaldi, A; Bond, J R; Borrill, J; Bouchet, F R; Boulanger, F; Burigana, C; Butler, R C; Chen, X; Chiang, L -Y; Christensen, P R; Clements, D L; Colombi, S; Colombo, L P L; Coulais, A; Cuttaia, F; Davies, R D; Davis, R J; de Bernardis, P; de Zotti, G; Delabrouille, J; Dickinson, C; Diego, J M; Dobler, G; Dole, H; Donzelli, S; Doré, O; Douspis, M; Dupac, X; Enßlin, T A; Finelli, F; Forni, O; Frailis, M; Franceschi, E; Galeotta, S; Ganga, K; Génova-Santos, R T; Ghosh, T; Giard, M; Giardino, G; Giraud-Héraud, Y; González-Nuevo, J; Górski, K M; Gregorio, A; Gruppuso, A; Hansen, F K; Harrison, D; Hernández-Monteagudo, C; Hildebrandt, S R; Hivon, E; Hobson, M; Holmes, W A; Hornstrup, A; Hovest, W; Huffenberger, K M; Jaffe, T R; Jaffe, A H; Juvela, M; Keihänen, E; Keskitalo, R; Kisner, T S; Knoche, J; Kunz, M; Kurki-Suonio, H; Lagache, G; Lähteenmäki, A; Lamarre, J -M; Lasenby, A; Lawrence, C R; Leach, S; Leonardi, R; Lilje, P B; Linden-Vørnle, M; Lubin, P M; Macías-Pérez, J F; Maffei, B; Maino, D; Mandolesi, N; Maris, M; Marshall, D J; Martin, P G; Martínez-González, E; Masi, S; Massardi, M; Matarrese, S; Mazzotta, P; Melchiorri, A; Mennella, A; Mitra, S; Miville-Deschênes, M -A; Moneti, A; Montier, L; Morgante, G; Mortlock, D; Munshi, D; Murphy, J A; Naselsky, P; Nati, F; Natoli, P; Nørgaard-Nielsen, H U; Noviello, F; Novikov, D; Novikov, I; Osborne, S; Oxborrow, C A; Pajot, F; Paladini, R; Paoletti, D; Peel, M; Perotto, L; Perrotta, F; Piacentini, F; Piat, M; Pierpaoli, E; Pietrobon, D; Plaszczynski, S; Pointecouteau, E; Polenta, G; Popa, L; Poutanen, T; Pratt, G W; Prunet, S; Puget, J -L; Rachen, J P; Reach, W T; Rebolo, R; Reinecke, M; Renault, C; Ricciardi, S; Ristorcelli, I; Rocha, G; Rosset, C; Rubiño-Martín, J A; Rusholme, B; Salerno, E; Sandri, M; Savini, G; Scott, D; Spencer, L; Stolyarov, V; Sudiwala, R; Suur-Uski, A -S; Sygnet, J -F; Tauber, J A; Terenzi, L; Tibbs, C T; Toffolatti, L; Tomasi, M; Tristram, M; Valenziano, L; Van Tent, B; Varis, J; Vielva, P; Villa, F; Vittorio, N; Wade, L A; Wandelt, B D; Ysard, N; Yvon, D; Zacchei, A; Zonca, A

    2013-01-01

    We perform an analysis of the diffuse low-frequency Galactic components in the Southern part of the Gould Belt system ($130^\\circ\\leq l\\leq 230^\\circ$ and $-50^\\circ\\leq b\\leq -10^\\circ$). Strong UV flux coming from the Gould Belt super-association is responsible for bright diffuse foregrounds that we observe from our position inside the system and that can help us improve our knowledge of the Galactic emission. Free-free emission and anomalous microwave emission (AME) are the dominant components at low frequencies ($\

  4. 11. XII anti Marko Mäetammele üle ES Sadolini maalipreemia

    Index Scriptorium Estoniae

    2003-01-01

    Preemiaga (20000 krooni) kaasnes kunstniku töödega unikaaltiraazhis seinakalender, kus M. Mäetamme töid kommenteerib Hanno Soans. Sadolini kunstikogusse läheb kunstniku esimene pleksiklaasimaal "Tennis" (1993)

  5. Book of Abstracts of the XII Portuguese-Spanish Symposium on Plant Water Relations (2014)

    OpenAIRE

    Coelho, Renato R. P.; Vaz, Margarida M.

    2014-01-01

    Contents PLENARY CONFERENCES AND THEMATIC CONFERENCES Molecular Mechanisms of Plant Adaptation to Drought Water Relations in the Irrigation Scheduling of Olive Orchards Physiological Limits for Plant-Based Water Stress Indicators Water Use in Montado Ecosystems Hydrological, Engineering and Physiological Approaches to Water Conservation From Leaf to Whole Plant Water Use Efficiency: Solving the Gaps Efficient Use of Water Under Mediterranean Conditions: Agronomic Too...

  6. 48 CFR Appendix F to Chapter 7 - Use of Collaborative Assistance Method for Title XII Activities

    Science.gov (United States)

    2010-10-01

    .... Such flexibility is also essential to the collaborative style which is responsive to LDC desires in... care must be taken to prevent actual or apparent organizational conflicts of interest in the... flexibility and responsibility for implementation placed with the technical assistance contractor, the host...

  7. [Clinical research XII. From the clinical judgment to the transversal design].

    Science.gov (United States)

    Talavera, Juan O; Rivas-Ruiz, Rodolfo

    2012-01-01

    A longitudinal study, such as a cohort or clinical trial, has the virtue of following the logical sequence in which occurs the components of causality phenomenon. However, in a cross-sectional survey, this logical sequence does not exist, because the three components are measured at one time: the basal state, maneuver, and result. However, the design of "clinical judgment" helps us to rebuild these components artificially in the time sequence in which they occurred. The way the population is assembled and how information is obtained, transversally and retrospectively, carries the risk of bias. While trying to associate a probable maneuver to an outcome in a pathological situation is difficult and often causes bias, a cross-sectional survey is the best to show the development of healthy people simulating a longitudinal study, like the height and weight estimation according to age. This type of design has been called "a longitudinal cross sectional study."

  8. Leaf anatomy of the South African Danthonieae (Poaceae. XII. Pentameris thuarii

    Directory of Open Access Journals (Sweden)

    R. P. Ellis

    1984-12-01

    Full Text Available The leaf blade anatomy of  Pentameris thuarii Beauv. is described and illustrated. It is shown that the leaf anatomy of  P. thuarii bears little resemblance to the anatomy of  P. macrocatyciiw (Steud. Schweick..  P. obiiisifolia (Hochst. Schweick., P. longiglumis (Nccs Stapf or P. dregeana Stapf. The leaf anatomy of P. thuarii was found to correspond closely with that of some specimens of Pentaschistis pallescens (Schrad. Stapf, P. silvatica Adamson and P. lonuosa (Trin. Stapf. The morphology of these  Pentaschistis specimens needs to be compared with that of  P. thuarii in order to establish whether the true relationships of  P. thuarii lie with these taxa. Anatomically. P. thuarii does not appear to be closelv related to anv species presently classified in Pentameris.

  9. The ACS Fornax Cluster Survey. XII. Diffuse Star Clusters in Early-type Galaxies

    CERN Document Server

    Liu, Yiqing; Lim, Sungsoon; Jordán, Andrés; Blakeslee, John; Côté, Patrick; Ferrarese, Laura; Pattarakijwanich, Petchara

    2016-01-01

    Diffuse star clusters (DSCs) are old and dynamically hot stellar systems that have lower surface brightness and more extended morphology than globular clusters (GCs). Using the images from HST/ACS Fornax Cluster Survey, we find that 12 out of 43 early-type galaxies (ETGs) in the Fornax cluster host significant numbers of DSCs. Together with literature data from the HST/ACS Virgo Cluster Survey, where 18 out of 100 ETGs were found to host DSCs, we systematically study the relationship of DSCs with GCs, and their host galaxy environment. Two DSC hosts are post-merger galaxies, with most of the other hosts either having low mass or showing clear disk components. We find that while the number ratio of DSCs to GCs is nearly constant in massive galaxies, the DSC-to-GC ratio becomes systematically higher in lower mass hosts. This suggests that DSCs may be more efficient at forming (or surviving) in low density environments. DSC hosts are not special either in their position in the cluster, or in the galactic color-m...

  10. The ACS Fornax Cluster Survey. XII. Diffuse Star Clusters in Early-type Galaxies

    Science.gov (United States)

    Liu, Yiqing; Peng, Eric W.; Lim, Sungsoon; Jordán, Andrés; Blakeslee, John; Côté, Patrick; Ferrarese, Laura; Pattarakijwanich, Petchara

    2016-10-01

    Diffuse star clusters (DSCs) are old and dynamically hot stellar systems that have lower surface brightness and more extended morphology than globular clusters (GCs). Using the images from Hubble Space Telescope (HST)/ACS Fornax Cluster Survey, we find that 12 out of 43 early-type galaxies (ETGs) in the Fornax Cluster host significant numbers of DSCs. Together with literature data from the HST/ACS Virgo Cluster Survey, where 18 out of 100 ETGs were found to host DSCs, we systematically study the relationship of DSCs with GCs and their host galaxy environment. Two DSC hosts are post-merger galaxies, with most of the other hosts either having low mass or showing clear disk components. We find that while the number ratio of DSCs to GCs is nearly constant in massive galaxies, the DSC-to-GC ratio becomes systematically higher in lower-mass hosts. This suggests that DSCs may be more efficient at forming (or surviving) in low-density environments. DSC hosts are not special either in their position in the cluster or in the galactic color-magnitude diagram. Why some disk and low-mass galaxies host DSCs while others do not is still a puzzle, however. The mean ages of DSC hosts and nonhosts are similar at similar masses, implying that formation efficiency rather than survival is the reason behind different DSC number fractions in ETGs.

  11. Uudised : Baltimaade suurim, XII "Jazzkaar". VII rahvusvaheline koorifestival. Leipzigis improviseeriti edukalt

    Index Scriptorium Estoniae

    2001-01-01

    23.-29. apr. toimuvast festivalist "Jazzkaar 2001". VII rahvusvahelisest koorifestivalist "Tallinn "2001". 6. ja 7. apr. Leipzigis toimunud V rahvusvahelisest improvisatsioonikonkursist, kus osalesid ka eesti interpreedid

  12. ExoMol molecular line lists XII: Line Lists for 8 isotopologues of CS

    CERN Document Server

    Paulose, Geethu; Yurchenko, Sergei N; Tennyson, Jonathan

    2015-01-01

    Comprehensive vibration-rotation line lists for eight isotopologues of carbon monosulphide (CS) ($^{12}$C$^{32}$S, $^{12}$C$^{33}$S, $^{12}$C$^{34}$S, $^{12}$C$^{36}$S, $^{13}$C$^{32}$S, $^{13}$C$^{33}$S, $^{13}$C$^{34}$S, $^{13}$C$^{36}$S) in their ground electronic states are calculated. These line lists are suitable for temperatures up to 3000 K. A spectroscopically-determined potential energy curve (PEC) and dipole moment curve (DMC) are taken from literature. This PEC is adapted to suit our method prior to the computation of ro-vibrational energies. The calculated energies are then substituted by experimental energies, where available, to improve the accuracy of the line lists. The {\\it ab initio} DMC is used without refinement to generate Einstein A coefficients. Full line lists of vibration-rotation transitions and partition functions are made available in an electronic form as supporting information to this paper and at \\url{www.exomol.com}.

  13. La canonica di San Lorenzo a Genova. Dinamiche istituzionali e rapporti sociali (secoli X-XII

    Directory of Open Access Journals (Sweden)

    Luca Filangieri

    2006-06-01

    Full Text Available Studiare la comunità canonicale genovese, dalle prime testimonianze relative alla presenza di un nucleo di convivenza sacerdotale presso la chiesa vescovile (metà del secolo X alla definitiva affermazione – in un contesto ormai comunale e arcidiocesano – dell’istituzione identificata come Capitulum: sono questi gli obiettivi perseguiti dal saggio, che propone un percorso attraverso la definizione dei rapporti con il vescovo, della gerarchia interna alla comunità, del patrimonio fondiario e immobiliare, della propria identità rispetto al comune e ai cives, per tentare di illustrare le dinamiche che caratterizzano i primi tre secoli di vita istituzionale della canonica della chiesa vescovile di Genova.

  14. Rodrigo el Campeador como princeps en los siglos XI y XII

    Directory of Open Access Journals (Sweden)

    Alberto MONTANER FRUTOS

    2010-07-01

    Full Text Available L’attribution à Rodrigue Diaz du titre de princeps dans la charte de donation à la cathédrale de Valence en 1098 et celui de princeps super militiam regis dans l’Historia Roderici révèlent deux attitudes très différentes envers le personnage. Le premier titre veut souligner l’autonomie de la principauté valencienne et présente Rodrigue comme menant la reconquête et la croisade hispaniques de sa propre volonté. Le second présente Rodrigue comme le sénéchal du roi Sanche, tombé par la suite en disgrâce du fait de la jalousie d’Alphonse et de ses courtisans, ce qui oblige le héros exilé à agir malgré lui. Le Carmen Campidoctoris reprend les deux titres, mais le premier est employé d’une façon éminemment honorifique, tandis que l’emploi du second révèle l’influence textuelle et idéologique de la biographie latine.La atribución a Rodrigo Díaz del título de princeps en el acta de dotación de la catedral de Valencia en 1098 y el de princeps super militiam regis en la Historia Roderici revelan dos actitudes profundamente distintas. La primera intitulación pretende subrayar la autonomía del señorío valenciano y reforzar el carácter de Rodrigo como caudillo de la reconquista y la cruzada hispánicas por voluntad propia. La segunda equivale a representar a Rodrigo como alférez del rey Sancho, luego caido en desgracia por la envidia del rey Alfonso y de sus cortesanos, por lo que, héroe perseguido, se ve empujado a actuar en el destierro por decisiones ajenas. El Carmen Campidoctoris recoge ambas titulaciones, pero la primera con un sentido eminentemente honorífico, mientras que la segunda revela su dependencia textual e ideológica respecto de la biografía latina.

  15. Elementos para una historia de la manufactura textil andalusi (siglos IX-XII)

    OpenAIRE

    Serrano Piedecasas, Luis

    1986-01-01

    La historiografía española adolece de un tipo de estudios puntuales sobre una serie de manifestaciones económicas; manifestaciones aparentemente desligadas del mundo rural, marginales en determinadas épocas, pero siempre testimoniales y premonitorias de períodos en que el proceso manufacturero y mercantil adquirirá, un peso específico propio, en el mundo feudal. La manufactura textil representa la base de despegue para la industria medieval, la palanca que permite a un grupo social disperso c...

  16. « La cultura secular y las artes suntuarias en Portugal (siglos XII-XIV)

    OpenAIRE

    Afonso, Luís U.

    2010-01-01

    En Portugal, escasean las artes suntuarias de la Edad Media y la inmensa mayoría de objetos de arte medieval que han llegado hasta nuestros días se asocian con la esfera religiosa. Sin embargo, hay evidencias que permiten matizar esta realidad y que prueban la difusión de las artes suntuarias y el enraizamiento de la cultura secular en Portugal entre 1100 y 1400. Este estudio comienza con un análisis de un pequeño número de objetos de lujo que representaban héroes tan diversos com...

  17. Investigations on carotenoids in lichens. XII. Some species from the Pyrenean Peninsula

    Directory of Open Access Journals (Sweden)

    Bazyli Czeczuga

    2014-01-01

    Full Text Available By means of column and thin-layer chromatography, the authors investigated the presence of various carotenoids in thalli of 12 species of lichens from the Pyrenean Peninsula. The following carotenoids were found: lycophyll, lycoxanthin, β-carotene, α-, β-cryptoxanthin, lutein, lutein epoxide, zeaxanthin, antheraxanthin, canthaxanthin, phoenicoxanthin, adonixanthin, α-doradexanthin, astaxanthin, diatoxanthin, neoxanthin, violaxanthin, mutatochrome, mutatoxanthin and rhodoxanthin. The total content of carotenoids ranged from 2.299 (Cetraria cucullata to 39.402 mg•g-1 dry weight (Pseudoevernia furfuraceae.

  18. 5. XII algusega kell 18.30 peetakse Tallinna Linnateatris kunstisalong Allee kunstioksjon

    Index Scriptorium Estoniae

    2003-01-01

    Oksjonil on 40 teost 35 autorilt. 1. detsembrist saab oksjonivalikuga tutvuda kunstisalongis Allee. Enampakkumisel on K. A. Senffi, E. von Gebhardti, O. Hoffmanni, M. Dückeri, A. Audova, A. Johani, E. Kõksi, N. Mei, L. Mikko, R. Sagritsa, E. Timbermanni, R. Uutmaa, A. Vardi, E. Wiiralti, J. Greenbergi, A. Janseni, K. Mäe, R. Nymani, Ü. Soosteri jt. tööd.

  19. Un arte de la palabra en la Cataluña del siglo XII

    Directory of Open Access Journals (Sweden)

    Puigarnau, Alfons

    2000-12-01

    Full Text Available In this article the author deals with a cultural approach of some manuscripts and artistic images during the 12th century in Catalonia. Behind this pages there is an intention of not no approaching to the so called Historicism and to check to what extent it is possible to make a History of Medieval Catalan Culture from a more hermeneutic point of view. Primary sources as liturgical manuscripts, wall paintings, altar pannels and inscriptions are used in order to understand the fact that behind all of these 'material culture' there is a "mental habit" of producing cultural and religious ideas in connection with three main aspects: a particular conception of the feudal Promise creating strong relations of power between lord and vassal; a eschatological mentality of being at Iast judged in an Apocalyptical context; and a particular connection of these Promise and Judgement through concepts as Memory and Time. The principal issue that is embodying feudal Promise, last Judgement, Memory and Time is the Art of Word, considering this 'word' as an aesthetic consequence of the historical fact of the Incarnation of Christ as Logos and Wisdom believed as Pantocrator (Omnipotens during the whole European Medieval period.[fr] Cet article propose une approche culturelle à quelques manuscrits et images artistiques du XlIème siècle catalan. Ces pages relèvent d'une intention de dépasser l'historicisme et constituent un essai de vérifier jusqu'à quel point il est possible de réaliser une histoire de la culture médiévale catalane d'un point de vue plus herméneutique. Des sources primaires telles que manuscrits liturgiques, peintures murales, frontais d'autel et inscriptions, sont utilisées pour mieux comprendre le fait que au-delà de cette "cuture matérielle" il existe une "habitude mentale" dans le déploiement d'idées culturelles et religieuses mises en liaison avec trois idées principales: une conception particulière du serment féodal, générateur de forts liens de pouvoir entre le seigneur et son vassal; une mentalité scathologique qui songe au Jugement dernier dans un contexte apocaliptique; et une connection spéciale entre ce Serment et ce Jugement au travers de notions comme la Mémoire et le Temps. L'idée centrale qui relie ces quatre éléments (serment, jugement, mémoire et temps c'est un Art de la Parole. Cette "parole" est ici considérée comme conséquence esthétique du fait de l'Incarnation du Christ comme Logos et Sagesse, adorée dans l'image iconographique du Pantocrator (omnipotens au cours du Moyen Âge européen.

  20. cDNA cloning of conotoxins with framework XII from several Conus species

    Institute of Scientific and Technical Information of China (English)

    Zhuguo Liu; Zheng Yu; Na Liu; Chongjia Zhao; Jie Hu; Qiuyun Dai

    2010-01-01

    In our efforts for cloning novel I2-superfamily conotoxins using the signal peptide sequence,we identified a novel eonotoxin Lt12.4 from Conus iitteratus.This gene has a fra mework Ⅻ(-C-C-C-C-CC-C-C-),which is distinct from the cysteine pattern I2-superfamily conotoxin(-C-C-CC CC-C-C-).Subsequently,we found the signal peptide sequence of Lt12.4 by 5'-RACE.Using this new sequence,we identified another five novel conotoxins with this cysteine pattern from four Conus species(Conus eburneus,Conus imperialis,Conus marmoreus,and C.litteratus).These novel conotoxins have the same cysteine pattern as the reported Gla-TxX and Gla-MII,and may contain Gla residues.Furthermore,they have the highly conserved signal peptide and hypervariable mature peptide sequences,and widely exist in Conus species.Therefore,it could be defined as a new superfamily of E-conotoxins.

  1. Human Development XII: A Theory for the Structure and Function of the Human Brain

    Directory of Open Access Journals (Sweden)

    Søren Ventegodt

    2008-01-01

    Full Text Available The human brain is probably the most complicated single structure in the biological universe. The cerebral cortex that is traditionally connected with consciousness is extremely complex. The brain contains approximately 1,000,000 km of nerve fibers, indicating its enormous complexity and which makes it difficult for scientists to reveal the function of the brain. In this paper, we propose a new model for brain functions, i.e., information-guided self-organization of neural patterns, where information is provided from the abstract wholeness of the biophysical system of an organism (often called the true self, or the “soul””. We present a number of arguments in favor of this model that provide self-conscious control over the thought process or cognition. Our arguments arise from analyzing experimental data from different research fields: histology, anatomy, electroencephalography (EEG, cerebral blood flow, neuropsychology, evolutionary studies, and mathematics. We criticize the popular network theories as the consequence of a simplistic, mechanical interpretation of reality (philosophical materialism applied to the brain. We demonstrate how viewing brain functions as information-guided self-organization of neural patterns can explain the structure of conscious mentation; we seem to have a dual hierarchical representation in the cerebral cortex: one for sensation-perception and one for will-action. The model explains many of our unique mental abilities to think, memorize, associate, discriminate, and make abstractions. The presented model of the conscious brain also seems to be able to explain the function of the simpler brains, such as those of insects and hydra.

  2. L’inspectio di un anonimo investigatore pisano nella prima metà del secolo XII

    Directory of Open Access Journals (Sweden)

    Andrea Puglia

    2013-01-01

    Full Text Available The article examines and publishes in the Appendix a document kept in the Archive of the Archbishop of Pisa, known until now only in a partial transcript, because was for a long time not available. The relevance of this document lies both in its materials and graphics characteristics , but also in its unique content, which presents a cross section of political and social life of the entourage of Bishops in the city and county in the first half of the Twelfth century. In fact, it shows the different sides of an inquest (inspectio conducted in the diocese of Pisa by an anonymous investigator appointed by the Archbishop of Pisa Hubert in 1137. The numerous stages of the inquest were probably recorded in some files and then, with the help of judges (and law experts and the graphic abilities of the episcopal clergy, were written in an entire parchment, with a clear and fluid book-Caroline and with a good rhetoric form. The goals of this document were surely informative, but we don’t exclude also a memorial and judicial objective. In conclusion, the inspectio give us the opportunity of studying the non-epistolographic practices of medieval communication and allows us to know a pragmatic and non-formal system of document building. This system is out of the field of notarial acts with legal effects (chartae and brevia recordationis and different from the writing of judicial records.

  3. Uudised : Baltimaade suurim, XII "Jazzkaar". VII rahvusvaheline koorifestival. Leipzigis improviseeriti edukalt

    Index Scriptorium Estoniae

    2001-01-01

    23.-29. apr. toimuvast festivalist "Jazzkaar 2001". VII rahvusvahelisest koorifestivalist "Tallinn "2001". 6. ja 7. apr. Leipzigis toimunud V rahvusvahelisest improvisatsioonikonkursist, kus osalesid ka eesti interpreedid

  4. 6.-30. XII on Tallinna keskraamatukogu peamaja näitusesaalis...

    Index Scriptorium Estoniae

    2004-01-01

    Piusa savikoja keraamikanäitus "Setus nähtud lood". Eksponeeritud jaapani raku-tehnikas tööd. Keraamikaateljee Savikoda tegutseb Piusa raudteejaama hoones 1997. aastast. Keraamikat valmistatakse käsitsi vormides (Signe Krigul) ja potikedral treides (Meelis Krigul)

  5. Elementos para una historia de la manufactura textil andalusi (siglos IX-XII

    Directory of Open Access Journals (Sweden)

    Luis SERRANO PIEDECASAS

    2009-11-01

    Full Text Available La historiografía española adolece de un tipo de estudios puntuales sobre una serie de manifestaciones económicas; manifestaciones aparentemente desligadas del mundo rural, marginales en determinadas épocas, pero siempre testimoniales y premonitorias de períodos en que el proceso manufacturero y mercantil adquirirá, un peso específico propio, en el mundo feudal. La manufactura textil representa la base de despegue para la industria medieval, la palanca que permite a un grupo social disperso constituirse en clase, el trabajo urbano que desarraigará a sectores del campesinado para convertirlos en plebe urbana. Nuestra historia textil no puede compararse a la de nuestros vecinos europeos, que supieron basar sus sociedades mercantiles en el proceso manufacturero de los paños. Las razones que nos impidieron conseguirlo son múltiples y quedan todas ellas fuera de nuestro limitado foco de atención, que no de nuestro interés.

  6. Origen del castillo y coto de Aranga, siglos X-XII

    Directory of Open Access Journals (Sweden)

    Barros, Carlos

    2009-12-01

    Full Text Available The importance of the fortress of the Higth Middle Age in the constitution of the feudal jurisdictions around the year 1000 is illustrated in this work which is the origin of the castle and a lordship of Aranga (now municipality of Galicia from the family of Traba. Th king Alfonso IX of Leon and Galicia transferred in 1193, the domain jurisdiction from a Aranga to Monastery of Sobrado, against the opinion of their vassals and peasants who, in 1168, preferring to continue to belong to the heirs of the counts of Traba and Aranga.

    La importancia de las fortalezas altomedievales en la constitución de las jurisdicciones feudales, en los alrededores del año 1000, se ilustra en este trabajo que trata del origen del castillo y coto de Aranga (actualmente, municipio de Galicia de la casa de Traba. El rey Alfonso IX de León y Galicia traspasa, en 1193, la jurisdicción señorial de Aranga al Monasterio de Sobrado, contra la opinión de sus campesinos y vasallos que, en 1168, preferían seguir perteneciendo a los herederos de los condes de Traba y Aranga.

  7. 18. XII kell 12 kaitstakse EKA E-meedia keskuses 4 magistritööd...

    Index Scriptorium Estoniae

    2002-01-01

    Kristel Sibul "Kehatud kehad - kehad ja identiteet internetis" (juh. Katrin Kivimaa), Ivika Kivi "Virtuaalsed õpitarkvarad" (juh. Mare Emmott Tralla), Maris Lindoja "Digitaalne ruum" (juh. Andres Kurg), Raul Keller "Corporate Consulting in the Digital Age - Jamming vith the Culture" (juh. Richard Barbrook)

  8. La Arquitectura de Ladrillo en la Provincia de Segovia, siglos XII Y XIII

    OpenAIRE

    Ruiz Hernando, José Antonio

    1988-01-01

    Desde hace mucho tiempo Antonio Ruiz Hernando tiene como ocupación primordial la de enseñar Historia del Arte en la Escuela de Arquitectura de Madrid. La dedicación y rigor que pone en esta tarea trasciende del espacio y del tiempo donde enseña y convierte su vida en un ejercicio, mezcla de conocimiento y emoción por el arte y su historia. Su ¡aborde investigación callada y seguida nos va ofreciendo con la periodicidad que en cada caso, precisa, aspectos y hechos desconocidos, que van ensambl...

  9. Eesti Kunstnike Liidu volikogu kogunes 19. XII 2005 Ku-Ku klubis

    Index Scriptorium Estoniae

    2006-01-01

    Vastuvõetud EKL-i 2006. a. eelarvest, Tallinna Linnagalerii tulevikust, tarbekunstinäituste vähesusest. SA Tallinna Kunstihoone nõukogu uueks liikmeks valiti Leonhard Lapin. EKL-i auliikmeteks valiti Edgar Valter, Lea Walter, Jaan Klõsheiko, Lembit Sarapuu, Heinz Valk ja Helge Pihelga

  10. 25 CFR 36.32 - Standard XII-Graduation requirements for a high school diploma.

    Science.gov (United States)

    2010-04-01

    ... general science area. (ii) One (1) unit in laboratory science areas, i.e., chemistry, physics, biology, zoology, laboratory anatomy. (5) Physical education—one (1) unit. (6) Practical arts—one (1) unit. Credit...

  11. Post common envelope binaries from SDSS. XII: The orbital period distribution

    CERN Document Server

    Gómez-Morán, A Nebot; Schreiber, M R; Rebassa-Mansergas, A; Schwope, A D; Southworth, J; Aungwerojwit, A; Bothe, M; Davis, P J; Kolb, U; Müller, M; Papadaki, C; Pyrzas, S; Rabitz, A; Rodríguez-Gil, P; Schmidtobreick, L; Schwarz, R; Tappert, C; Toloza, O; Vogel, J; Zorotovic, M

    2011-01-01

    The complexity of the common envelope phase and of magnetic stellar wind braking currently limits our understanding of close binary evolution. Because of their intrinsically simple structure, observational population studies of white dwarf plus main sequence (WDMS) binaries hold the potential to test theoretical models and constrain their parameters. The Sloan Digital Sky Survey (SDSS) has provided a large and homogeneously selected sample of WDMS binaries, which we are characterising in terms of orbital and stellar parameters. We have obtained radial velocity information for 385 WDMS binaries from follow-up spectroscopy, and for an additional 861 systems from the SDSS sub-spectra. Radial velocity variations identify 191 of these WDMS binaries as post common envelope binaries (PCEBs). Orbital periods of 58 PCEBs were subsequently measured, predominantly from time-resolved spectroscopy, bringing the total number of SDSS PCEBs with orbital parameters to 79. Observational biases inherent to this PCEB sample were...

  12. Planck 2015 results: XII. Full focal plane simulations

    DEFF Research Database (Denmark)

    Ade, P. A R; Aghanim, N.; Arnaud, M.

    2016-01-01

    , comprising 104 mission realizations reduced to about 106 maps. The resulting maps incorporate the dominant instrumental, scanning, and data analysis effects, and the remaining subdominant effects will be included in future updates. Generated at a cost of some 25 million CPU-hours spread across multiple high...

  13. 48 CFR 715.370-1 - Title XII selection procedure-general.

    Science.gov (United States)

    2010-10-01

    ... essential, a statement of work, estimate of personnel requirements, special requirements (logistic support... statement of work, an estimate of the personnel required, and special provisions (such as logistic support, government furnished equipment, and so forth), a proposed contract format, and evaluation criteria. No cost...

  14. La geometria del còdex 80 (s. XII de la catedral de Tortosa

    Directory of Open Access Journals (Sweden)

    Lluís i Ginovart, Josep

    2015-12-01

    Full Text Available The geometry in codex 80 of the Capitular Archive has traditionally been understood as a complete text and attributed to Gerbert of Aurillac (c. 940-1003. From a new reading of the text, we can say that it is a miscellaneous writing about geometry, composed of three independent parts: one containing the Geometria Incerti Auctoris apocryphical by Gerbert of Aurillac (c. 940-1003; another one is a fragment of De Nuptiis Philologiae et Mercurii by Martianus Capella (fl . 430 from Ergasticis Schematibus of Book VII of the Geometry; and finally there is a gloss to the Elementa by Euclides (c. 325-c. 265 bC. by Al-Ḥajjāj ibn Yūsuf ibn Maṭar (786-833. The interpretation of the geometrical propositions provides knowledge about the indirect measure of places which are inaccessible using medieval instrumental, the astrolabe, mirrors, cane and squares.[ct] La geometria del còdex 80 de l’Arxiu Capitular de Tortosa ha estat tradicionalment atribuïda, com un text únic, a Gerbert d’Orlhac (c. 940-1003. Una nova lectura del text ens permet assegurar que es tracta d’un text de caràcter miscel·lani de geometria, compost per tres textos independents: una part pertany a la Geometria Incerti Auctoris apòcrifa de Gerbert d’Orlhac; una altra, al fragment De Nuptiis Philologiae et Mercurii de Marcià Capella (fl . 430 Ergasticis Schematibus, del llibre VII de la Geometria; i, finalment, s’hi llegeix una glossa als Elementa d’Euclides (c. 325-c. 265 aC. d’Al-Ḥajjāj ibn Yūsuf ibn Maṭar (786-833. La interpretació de les proposicions de la geometria dóna el coneixement de la mesura indirecta de llocs als quals no es pot accedir amb l’instrumental medieval, és a dir, amb astrolabi, miralls, bastons i escaires.

  15. The Sloan Lens ACS Survey. XII. Extending Strong Lensing to Lower Masses

    NARCIS (Netherlands)

    Shu, Yiping; Bolton, Adam S.; Brownstein, Joel R.; Montero-Dorta, Antonio D.; Koopmans, Léon V. E.; Treu, Tommaso; Gavazzi, Raphaël; Auger, Matthew W.; Czoske, Oliver; Marshall, Philip J.; Moustakas, Leonidas A.

    2015-01-01

    We present observational results from a new Hubble Space Telescope (HST) Snapshot program to extend the methods of the Sloan Lens ACS (SLACS) Survey to lower lens-galaxy masses. We discover 40 new galaxy-scale strong lenses, which we supplement with 58 previously discovered SLACS lenses. In addition

  16. The VLT-FLAMES Tarantula Survey XII. Rotational velocities of the single O-type stars

    CERN Document Server

    Ramírez-Agudelo, O H; Sana, H; de Koter, A; Sabín-Sanjulían, C; de Mink, S E; Dufton, P L; Gräfener, G; Evans, C J; Herrero, A; Langer, N; Lennon, D J; Apellániz, J Maíz; Markova, N; Najarro, F; Puls, J; Taylor, W D; Vink, J S

    2013-01-01

    Aims. Using ground based multi-object optical spectroscopy obtained in the framework of the VLT-FLAMES Tarantula Survey (VFTS), we aim to establish the (projected) rotational velocity distribution for a sample of 216 presumably single O-type stars in 30 Doradus (30 Dor). Methods. We measured projected rotational velocities, \\vrot, by means of a Fourier transform method and a profile fitting method applied on a set of isolated spectral lines. We also used an iterative deconvolution procedure to infer the probability density, $\\rm{P(\\veq)}$, of the equatorial rotational velocity, \\veq. Results. The distribution of \\vrot\\ shows a two-component structure: a peak around 80 \\kms\\ and a high-velocity tail extending up to $\\sim$600 \\kms. This structure is also present in the inferred distribution $\\rm{P(\\veq)}$ with around 80% of the sample having 0 $<$ \\veq\\, $\\leq\\, 300$ \\kms\\ and the other 20% distributed in the high-velocity region. Conclusions. Most of the stars in our sample rotate with a rate less than 20%\\...

  17. 11. XII anti Marko Mäetammele üle ES Sadolini maalipreemia

    Index Scriptorium Estoniae

    2003-01-01

    Preemiaga (20000 krooni) kaasnes kunstniku töödega unikaaltiraazhis seinakalender, kus M. Mäetamme töid kommenteerib Hanno Soans. Sadolini kunstikogusse läheb kunstniku esimene pleksiklaasimaal "Tennis" (1993)

  18. Summi Pontificatus : the international relation of the Holy See under Pius XII

    OpenAIRE

    Gabriel Ribeiro Barnabé

    2011-01-01

    Resumo: A pesquisa liga-se ao estudo das relações internacionais da Santa Sé. Considerando que essas se operam como relações entre a Igreja e o Estado, analiso, no primeiro capítulo, as principais teorias que as explicam. Primeiramente caracterizo as quatro propriedades da Igreja (una, santa, católica e apostólica), das quais se destaca a catolicidade, isto é, a universalidade, que a move em missão internacional por todo o mundo. Em seguida, comento a teoria da plenitudo potestatis papae, as ...

  19. Studies on Idiocerine Leafhoppers XII. Idioscopus Clavosignatus spec. nov. (Homoptera, Cicadellidae)

    NARCIS (Netherlands)

    Maldonado Capriles, J.

    1974-01-01

    Among material from the Leiden Museum loaned to me for study a new species of Idioscopus was found that is described here. A summary of the species in the genus is added in two tables. In the descriptions below 30 micrometer units are equivalent to 1.0 mm. The types are deposited in the Leiden Museu

  20. EU Interlaboratory comparison study veterinary XII . Bacteriological detection of Salmonella in chicken faeces

    NARCIS (Netherlands)

    Kuijpers AFA; Veenman C; Mooijman KA; LZO

    2009-01-01

    In 2009 heeft een vergelijkende studie onder 34 Nationale Referentie Laboratoria (NRL's) uitgewezen dat alle NRL's in staat waren hoge en lage concentraties Salmonella in kippenmest aan te tonen. Van deze laboratoria lieten er 33 direct zien dat zij het onderzoek met succes en volgens de

  1. Research Linking Teacher Preparation and Student Performance: Teacher Education Yearbook XII

    Science.gov (United States)

    Guyton, Edith M., Ed.; Dangel, Julie Rainer, Ed.

    2004-01-01

    The case studies, research, and projects presented here strike at the very heart of effective teaching. The specific practices to improve student performance will spark classroom discussion and improve teacher practice. After a foreword by Frances van Tassell and an introduction by Edith M. Guyton and Julie Rainer Dangel, this book is divided into…

  2. The Transit Light Curve Project. XII. Six Transits of the Exoplanet XO-2b

    CERN Document Server

    Fernandez, Jose M; Winn, Joshua N; Torres, Guillermo; Shporer, Avi; Mazeh, Tsevi; Esquerdo, Gilbert A; Everett, Mark E

    2009-01-01

    We present photometry of six transits of the exoplanet XO-2b. By combining the light-curve analysis with theoretical isochrones to determine the stellar properties, we find the planetary radius to be 0.996 +0.031/-0.018 rjup and the planetary mass to be 0.565 +/- 0.054 mjup. These results are consistent with those reported previously, and are also consistent with theoretical models for gas giant planets. The mid-transit times are accurate to within 1 min and are consistent with a constant period. However, the period we derive differs by 2.5 sigma from the previously published period. More data are needed to tell whether the period is actually variable (as it would be in the presence of an additional body) or if the timing errors have been underestimated.

  3. Division XII / Commission 5 / Working Group Virtual Observatories, Data Centers & Networks

    Science.gov (United States)

    Hanisch, Robert J.; Barbuy, Beatriz; Bentley, Robert D.; Benvenuti, Piero; Egret, Daniel; Fukushima, Toshio; Genova, Françoise; Grosbol, Preben J.; Helou, George; Norris, Raymond P.; Quinn, Peter

    The Working Group Virtual Observatories, Data Centers, and Networks was established under Commission 5 at the Prague General Assembly in 2006. The purpose of the WG is to provide IAU oversight of the activities of the International Virtual Observatory Alliance (IVOA, ), to encourage data centers and other data providers to archive and publish data according to IVOA standards, and to help assure that astronomical research facilities are electronically linked with current network technologies. The WG coordinates activities closely with the WG-FITS, as the IVOA uses FITS as its primary format for binary data exchange, and the WG on Astronomical Data.

  4. 77 FR 59669 - Comment Request for Information Collection; Unemployment Insurance (UI) Title XII Advances and...

    Science.gov (United States)

    2012-09-28

    ... Constitution Avenue NW. Washington, DC 20210. Telephone number: 202-693-3008 (this is not a toll-free number). Individuals with hearing or speech impairments may access the telephone number above via TTY by calling the toll-free Federal Information Relay Service at 1-877-889-5627 (TTY/TDD). Email:...

  5. The VLT-FLAMES Tarantula Survey. XII. Rotational velocities of the single O-type stars

    Science.gov (United States)

    Ramírez-Agudelo, O. H.; Simón-Díaz, S.; Sana, H.; de Koter, A.; Sabín-Sanjulían, C.; de Mink, S. E.; Dufton, P. L.; Gräfener, G.; Evans, C. J.; Herrero, A.; Langer, N.; Lennon, D. J.; Maíz Apellániz, J.; Markova, N.; Najarro, F.; Puls, J.; Taylor, W. D.; Vink, J. S.

    2013-12-01

    Context. The 30 Doradus (30 Dor) region of the Large Magellanic Cloud, also known as the Tarantula nebula, is the nearest starburst region. It contains the richest population of massive stars in the Local Group, and it is thus the best possible laboratory to investigate open questions on the formation and evolution of massive stars. Aims: Using ground-based multi-object optical spectroscopy obtained in the framework of the VLT-FLAMES Tarantula Survey (VFTS), we aim to establish the (projected) rotational velocity distribution for a sample of 216 presumably single O-type stars in 30 Dor. The sample is large enough to obtain statistically significant information and to search for variations among subpopulations - in terms of spectral type, luminosity class, and spatial location - in the field of view. Methods: We measured projected rotational velocities, νesini, by means of a Fourier transform method and a profile fitting method applied to a set of isolated spectral lines. We also used an iterative deconvolution procedure to infer the probability density, P(νe), of the equatorial rotational velocity, νe. Results: The distribution of νesini shows a two-component structure: a peak around 80 kms-1 and a high-velocity tail extending up to ~600 kms-1. This structure is also present in the inferred distribution P(νe) with around 80% of the sample having 0 low-velocity peak is consistent with what has been found in other studies for late O- and early B-type stars. Conclusions: Most of the stars in our sample rotate with a rate less than 20% of their break-up velocity. For the bulk of the sample, mass loss in a stellar wind and/or envelope expansion is not efficient enough to significantly spin down these stars within the first few Myr of evolution. If massive-star formation results in stars rotating at birth with a large portion of their break-up velocities, an alternative braking mechanism, possibly magnetic fields, is thus required to explain the present-day rotational properties of the O-type stars in 30 Dor. The presence of a sizeable population of fast rotators is compatible with recent population synthesis computations that investigate the influence of binary evolution on the rotation rate of massive stars. Even though we have excluded stars that show significant radial velocity variations, our sample may have remained contaminated by post-interaction binary products. That the high-velocity tail may be populated primarily (and perhaps exclusively) by post-binary interaction products has important implications for the evolutionary origin of systems that produce gamma-ray bursts. Based on observations collected at the European Southern Observatory under program ID 182.D-0222.Full Tables 3 and 4 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/560/A29

  6. Military-political and Dynastic Princes Russian Contacts with the Crusaders XII – Early XIII Centuries

    Directory of Open Access Journals (Sweden)

    Viktor Muderevych

    2015-06-01

    Full Text Available The article is dedicated to the problems of military-political contacts between the Russian princes and Crusaders. In particular, it was considered the relationship of the princes with the Scandinavian, German, Czech and Polish parties of military campaigns on the Middle East. Chronologically, these symptomatic contacts were limited by the period of the first four crusades. The Rusychi did not participate in the Crusades, however, they had repeatedly entered into relationships with their participants. Often, for the sake of personal interests. Special attention is paid to the dynastic ties of princes with the European Crusaders, who played a fundamental role in the translation of crusading ideas into the territory of Kievan Rus. Due to this we are able to understand the reception of these ideas in the ancient social and cultural space. Of particular interest is the reflection of ancient chroniclers about the events related to the crusading movement.

  7. Risk factors for indications of intraoperative blood transfusion among patients undergoing surgical treatment for colorectal adenocarcinoma Fatores de risco para indicação de transfusão sanguínea intraoperatória em doentes operados por adenocarcinoma colorretal

    Directory of Open Access Journals (Sweden)

    Iara Gonçalves

    2009-09-01

    Full Text Available CONTEXT: Identification of risk factors for requiring transfusions during surgery for colorectal cancer may lead to preventive actions or alternative measures, towards decreasing the use of blood components in these procedures, and also rationalization of resources use in hemotherapy services. This was a retrospective case-control study using data from 383 patients who were treated surgically for colorectal adenocarcinoma at "Fundação Pio XII", in Barretos-SP, Brazil, between 1999 and 2003. OBJECTIVE: To recognize significant risk factors for requiring intraoperative blood transfusion in colorectal cancer surgical procedures. METHODS: Univariate analyses were performed using Fisher's exact test or the chi-squared test for dichotomous variables and Student's t test for continuous variables, followed by multivariate analysis using multiple logistic regression. RESULTS: In the univariate analyses, height (P = 0.06, glycemia (P = 0.05, previous abdominal or pelvic surgery (P = 0.031, abdominoperineal surgery (POBJETIVO: Identificar fatores de risco de indicação de transfusão sanguínea intraoperatória em doentes submetidos a tratamento cirúrgico por adenocarcinoma colorretal. MÉTODOS: Estudo retrospectivo, tipo caso-controle, realizado na Fundação Pio XII, em Barretos, SP, utilizando-se base de dados de prontuários de 383 pacientes admitidos entre 1999 e 2003. Utilizou-se teste exato de Fischer ou qui ao quadrado para variáveis dicotômicas e t de Student para variáveis contínuas, na análise univariada, adotando-se nível de significância de 10% (P<0,10; na análise multivariada foi aplicado o teste de regressão logística múltipla, com nível de significância de 5% (P<0,05; as razões de chances e os respectivos intervalos de confiança de 95% foram calculados. RESULTADOS: Nas análises univariadas foram consideradas significantes as variáveis altura (P = 0,06, glicemia (P = 0,05, antecedente de cirurgia abdominal ou pélvica (P

  8. hPDGF-B基因转染对Beagle犬牙龈成纤维细胞生物学活性的影响%Biological Effects of Human Platelet-Derived Growth Factor-B Gene Transfection on Gingival Fibroblasts of Beagle Dog

    Institute of Scientific and Technical Information of China (English)

    钟泉; 闫福华; 李艳芬; 陈超

    2013-01-01

    Objective To evaluate the biological effects of human platelet-derived growth factor-B gene transfection on gingival fibroblasts . Methods The plasmid(EX-A0380-M03) carried human plate-let-derived growth factor-B(hPDGF-B) gene was transfected into gingival fibroblasts by LipofectamineTM 2000 . Morphological changes of transfected cells were recorded by optical and fluorescent microscope . Then ,MTT and flow cytometry were used to estimate the proliferation and apoptosis of gene-modified cells . The expression of collagen I and XII ,as well as theα-SMA(α-Smooth Muscle Actin) was detected by Real-time Quantitative PCR . Results Compared to the normal cells ,partial transfected cells presen-ted startlike ,polygonal ,and neuron-like . Cells proliferation was enhanced after gene interference ,but apoptosis did not appeared . At transcription level ,the expression of Collagen I was up-regulated ,while Collagen XII and α-SMA were down-regulated . Conclusion The enhanced proliferation of gingival fibro-blasts were due to paracrine and autocrine modes of fusion protein PDGF-BB-eGFP synthetized by gene modified cells . Transfeced cells did not present reverse differentiation ,and the extracellular matrix re-modeling ability of those cells were down . The synthesis of Collagen I of hPDGF-B gene modified cells ascended no tably .%目的:检测hPDGF-B基因转染对Beagle犬牙龈成纤维细胞生物学活性的影响。方法使用脂质体LipofectamineTM 2000将携带hPDGF-B基因的质粒EX-A0380-M03转染至Beagle犬牙龈成纤维细胞,观察转染后细胞的形态以及增殖的变化;流式细胞仪检测转染细胞的周期以及凋亡情况;Real-time PCR法检测转染后细胞表达Collagen I、Collagen XII、α-SM A的变化。结果转染后的牙龈成纤维细胞形态多样,但增殖显著;转染组S期细胞比率增高,转染细胞未出现凋亡;转染后细胞上调Collagen I基因的表达,下调Collagen XII和α-SM A

  9. Tissue factor pathway inhibitor endocytosis.

    Science.gov (United States)

    Schwartz, A L; Broze, G J

    1997-10-01

    Tissue factor pathway inhibitor (TFPI), a 42 kD protein, provides the physiological inhibition of tissue factor initiated coagulation by inhibition of both factor Xa and factor VIIa/tissue factor. In plasma, most TFPI is lipoprotein bound with an additional "releasable" pool bound to the endothelial cell surface. TFPI clearance is via receptor mediated endocytosis into liver. Heparin sulfate proteoglycans and LRP (low density lipoprotein receptor-related protein), an extremely large (∼600 kD) cell surface protein, primarily mediate this clearance, although additional TFPI binding sites and endocytosis pathways exist. (Trends Cardiovasc Med 1997; 7:234-239). © 1997, Elsevier Science Inc.

  10. A factor analysis to detect factors influencing building national brand

    Directory of Open Access Journals (Sweden)

    Naser Azad

    Full Text Available Developing a national brand is one of the most important issues for development of a brand. In this study, we present factor analysis to detect the most important factors in building a national brand. The proposed study uses factor analysis to extract the most influencing factors and the sample size has been chosen from two major auto makers in Iran called Iran Khodro and Saipa. The questionnaire was designed in Likert scale and distributed among 235 experts. Cronbach alpha is calculated as 84%, which is well above the minimum desirable limit of 0.70. The implementation of factor analysis provides six factors including “cultural image of customers”, “exciting characteristics”, “competitive pricing strategies”, “perception image” and “previous perceptions”.

  11. The population factor.

    Science.gov (United States)

    Kats, G

    1983-01-01

    Reducing population growth is essentil to Egypt's broader efforts to improve facilities, services, and the phsycial quality of life. Although a family planning program has existed since the mid-1950s, the 2.7% annual rate of population growth has not changed in 30 years. Nasser and the other "free officers" who seized power in 1952 became concerned about the adverse effects of the rapidly growing population, but perhaps out of concern with a possible religious backlash, they confined themselves to launching studies and subsidizing several dozen private family planning clinics. From 1962-72, the number of private clinics grew from 28 to 480, and family planning was introduced in government healthclinics in 1965. Such clinics are mainly located in rural areas and are staffed by doctors and other personnel who are not members of the local community and are not very effective at promoting family planning. Local girls and women called Rayadet were recruited to promote the idea to birth control in local communities. By 1970, 12.6% of Egyptians were using reliable contraception. A national survey 12 years later found 34% using contraception, buth the figure seems high. Approximately 60-65% of eligible couples would need to practice birth control for Egypt to reach a less than 1% annuel increase. The Egyptian government hopes to slow population growth to 1% by the year 2000, but major problems of motivation remain especially among the rural poor. Several factors may lead to success of the family planning effort: 1) financial and technical support from international family planning sources has grown rapidley and is likely to remain high; 2) the mortality rate has dropped from 17.8/1000 in 1952 to about half that level, while the rate of natural increase is about the same, suggesting that future reductions in the birth rate will translate to a reduced rate of natural increase, and that parents will be less reluctant to practice faimly planning if there is a greater chance

  12. Risk factors for periodontal disease.

    Science.gov (United States)

    Genco, Robert J; Borgnakke, Wenche S

    2013-06-01

    Risk factors play an important role in an individual's response to periodontal infection. Identification of these risk factors helps to target patients for prevention and treatment, with modification of risk factors critical to the control of periodontal disease. Shifts in our understanding of periodontal disease prevalence, and advances in scientific methodology and statistical analysis in the last few decades, have allowed identification of several major systemic risk factors for periodontal disease. The first change in our thinking was the understanding that periodontal disease is not universal, but that severe forms are found only in a portion of the adult population who show abnormal susceptibility. Analysis of risk factors and the ability to statistically adjust and stratify populations to eliminate the effects of confounding factors have allowed identification of independent risk factors. These independent but modifiable, risk factors for periodontal disease include lifestyle factors, such as smoking and alcohol consumption. They also include diseases and unhealthy conditions such as diabetes mellitus, obesity, metabolic syndrome, osteoporosis, and low dietary calcium and vitamin D. These risk factors are modifiable and their management is a major component of the contemporary care of many periodontal patients. Genetic factors also play a role in periodontal disease and allow one to target individuals for prevention and early detection. The role of genetic factors in aggressive periodontitis is clear. However, although genetic factors (i.e., specific genes) are strongly suspected to have an association with chronic adult periodontitis, there is as yet no clear evidence for this in the general population. It is important to pursue efforts to identify genetic factors associated with chronic periodontitis because such factors have potential in identifying patients who have a high susceptibility for development of this disease. Many of the systemic risk factors

  13. Growth Factors in Synaptic Function

    Directory of Open Access Journals (Sweden)

    Vivian Yi Nuo Poon

    2013-09-01

    Full Text Available Synapses are increasingly recognized as key structures that malfunction in disorders like schizophrenia, mental retardation, and neurodegenerative diseases. The importance and complexity of the synapse has fuelled research into the molecular mechanisms underlying synaptogenesis, synaptic transmission, and plasticity. In this regard, neurotrophic factors such as netrin, Wnt, transforming growth factor-beta (TGF-beta, tumor necrosis factor-α (TNF-α, and others have gained prominence for their ability to regulate synaptic function. Several of these factors were first implicated in neuroprotection, neuronal growth, and axon guidance. However, their roles in synaptic development and function have become increasingly clear, and the downstream signaling pathways employed by these factors have begun to be elucidated. In this review, we will address the role of these factors and their downstream effectors in synaptic function in vivo and in cultured neurons.

  14. Factors Affecting Medical Service Quality.

    OpenAIRE

    Ali Mohammad Mosadeghrad

    2014-01-01

    A better understanding of factors influencing quality of medical service can pinpoint better strategies for quality assurance in medical services. This study aimed to identify factors affecting the quality of medical services provided by Iranian physicians.Exploratory in-depth individual interviews were conducted with sixty-four physicians working in various medical institutions in Iran.Individual, organizational and environmental factors enhance or inhibit the quality of medical services. Qu...

  15. Factors Affecting Medical Service Quality

    OpenAIRE

    Mosadeghrad, Ali Mohammad

    2014-01-01

    Abstract Background A better understanding of factors influencing quality of medical service can pinpoint better strategies for quality assurance in medical services. This study aimed to identify factors affecting the quality of medical services provided by Iranian physicians. Methods Exploratory in-depth individual interviews were conducted with sixty-four physicians working in various medical institutions in Iran. Results Individual, organizational and environmental factors enhance or inhib...

  16. Risk factors for thyroid cancer.

    Science.gov (United States)

    Nikiforov, Y E; Fagin, J A

    1997-01-01

    The potential risk factors for thyroid carcinoma development include genetic predisposition, exposure to therapeutic or environmental ionizing radiation, residence in areas of iodine deficiency or excess, history of preexisting benign thyroid disease, as well as hormonal and reproductive factors. In this review, we analyze some of the epidemiological data, as well as the possible molecular mechanisms by which certain environmental and genetic factors might predispose to thyroid tumorigenesis. (c) 1997, Elsevier Science Inc. (Trends Endocrinol Metab 1997; 8:20-25).

  17. Matrix Factorization and Matrix Concentration

    OpenAIRE

    Mackey, Lester

    2012-01-01

    Motivated by the constrained factorization problems of sparse principal components analysis (PCA) for gene expression modeling, low-rank matrix completion for recommender systems, and robust matrix factorization for video surveillance, this dissertation explores the modeling, methodology, and theory of matrix factorization.We begin by exposing the theoretical and empirical shortcomings of standard deflation techniques for sparse PCA and developing alternative methodology more suitable for def...

  18. Optimal Algorithm for Algebraic Factoring

    Institute of Scientific and Technical Information of China (English)

    支丽红

    1997-01-01

    This paper presents on optimized method for factoring multivariate polynomials over algebraic extension fields defined by an irreducible ascending set. The basic idea is to convert multivariate polynomials to univariate polynomials and algebraic extension fields to algebraic number fields by suitable integer substituteions.Then factorize the univariate polynomials over the algebraic number fields.Finally,construct mulativariate factors of the original polynomial by Hensel lemma and TRUEFACTOR test.Some examples with timing are included.

  19. Strange nucleon form-factors

    Science.gov (United States)

    Maas, F. E.; Paschke, K. D.

    2017-07-01

    A broad program measuring parity-violation in electron-nuclear scattering has now provided a large set of precision data on the weak-neutral-current form-factors of the proton. Under comparison with well-measured electromagnetic nucleon form-factors, these measurements reveal the role of the strange quark sea on the low-energy interactions of the proton through the strange-quark-flavor vector form-factors. This review will describe the experimental program and the implications of the global data for the strange-quark vector form-factors. We present here a new fit to the world data.

  20. Summable series and convergence factors

    CERN Document Server

    Moore, Charles N

    1938-01-01

    Fairly early in the development of the theory of summability of divergent series, the concept of convergence factors was recognized as of fundamental importance in the subject. One of the pioneers in this field was C. N. Moore, the author of the book under review.... Moore classifies convergence factors into two types. In type I he places the factors which have only the property that they preserve convergence for a convergent series or produce convergence for a summable series. In type II he places the factors which not only maintain or produce convergence but have the additional property that

  1. First course in factor analysis

    CERN Document Server

    Comrey, Andrew L

    2013-01-01

    The goal of this book is to foster a basic understanding of factor analytic techniques so that readers can use them in their own research and critically evaluate their use by other researchers. Both the underlying theory and correct application are emphasized. The theory is presented through the mathematical basis of the most common factor analytic models and several methods used in factor analysis. On the application side, considerable attention is given to the extraction problem, the rotation problem, and the interpretation of factor analytic results. Hence, readers are given a background of

  2. Schemes for Deterministic Polynomial Factoring

    CERN Document Server

    Ivanyos, Gábor; Saxena, Nitin

    2008-01-01

    In this work we relate the deterministic complexity of factoring polynomials (over finite fields) to certain combinatorial objects we call m-schemes. We extend the known conditional deterministic subexponential time polynomial factoring algorithm for finite fields to get an underlying m-scheme. We demonstrate how the properties of m-schemes relate to improvements in the deterministic complexity of factoring polynomials over finite fields assuming the generalized Riemann Hypothesis (GRH). In particular, we give the first deterministic polynomial time algorithm (assuming GRH) to find a nontrivial factor of a polynomial of prime degree n where (n-1) is a smooth number.

  3. Factorization method of quadratic template

    Science.gov (United States)

    Kotyrba, Martin

    2017-07-01

    Multiplication of two numbers is a one-way function in mathematics. Any attempt to distribute the outcome to its roots is called factorization. There are many methods such as Fermat's factorization, Dixońs method or quadratic sieve and GNFS, which use sophisticated techniques fast factorization. All the above methods use the same basic formula differing only in its use. This article discusses a newly designed factorization method. Effective implementation of this method in programs is not important, it only represents and clearly defines its properties.

  4. Social networks and factor markets

    DEFF Research Database (Denmark)

    Abay, Kibrom Araya; Kahsay, Goytom Abraha; Berhane, Guush

    In the absence of well-established factor markets, the role of indigenous institutions and social networks can be substantial for mobilizing factors for agricultural production. We investigate the role of an indigenous social network in Ethiopia, the iddir, in facilitating factor market...... sources. These results point out the roles non-market arrangements, such as social networks, can play in mitigating market inefficiencies in poor rural markets....... transactions among smallholder farmers. Using detailed longitudinal household survey data and employing a difference-in-differences approach, we find that iddir membership improves households’ access to factor markets. Specifically, we find that joining an iddir network improves households’ access to land...

  5. Women's Career Success: A Factor Analytic Study of Contributing Factors.

    Science.gov (United States)

    Gaskill, LuAnn Ricketts

    1991-01-01

    A survey of 466 women employed in retailing received 205 responses identifying (1) factors influencing the success and advancement of women in retailing and (2) how those factors differ for women in upper versus middle positions. Upper-level executives placed more importance on ambition and abilities; midlevel executives credited opportunity and…

  6. Factorized molecular wave functions: Analysis of the nuclear factor

    Energy Technology Data Exchange (ETDEWEB)

    Lefebvre, R., E-mail: roland.lefebvre@u-psud.fr [Institut des Sciences Moléculaires d’ Orsay, Bâtiment 350, UMR8214, CNRS- Université. Paris-Sud, 91405 Orsay, France and Sorbonne Universités, UPMC Univ Paris 06, UFR925, F-75005 Paris (France)

    2015-06-07

    The exact factorization of molecular wave functions leads to nuclear factors which should be nodeless functions. We reconsider the case of vibrational perturbations in a diatomic species, a situation usually treated by combining Born-Oppenheimer products. It was shown [R. Lefebvre, J. Chem. Phys. 142, 074106 (2015)] that it is possible to derive, from the solutions of coupled equations, the form of the factorized function. By increasing artificially the interstate coupling in the usual approach, the adiabatic regime can be reached, whereby the wave function can be reduced to a single product. The nuclear factor of this product is determined by the lowest of the two potentials obtained by diagonalization of the potential matrix. By comparison with the nuclear wave function of the factorized scheme, it is shown that by a simple rectification, an agreement is obtained between the modified nodeless function and that of the adiabatic scheme.

  7. FACTORING- CREDIT OPPORTUNITIES IN ROMANIA

    Directory of Open Access Journals (Sweden)

    ADELA IONESCU

    2013-05-01

    Full Text Available Capital is the main factor of production, business development becomes virtually impossible without taking into account the financial market and the resources it provides to businesses. Any business, regardless of its degree of development, is involving direct contact with financial markets, namely the institutions that mediate mobilization of capital and the services they provide. Understanding the functioning of the financial system, the specific financial mechanisms through which savings are allocated to support capital investments and the costs and risks involved is essential for the development of a solid base for business. In this context, factoring operations can support economic agents, allowing a transfer of commercial receivables from their holder to a factor who commits to their recovery and guarantee such operations even if temporary or permanent insolvency of the debtor . Thus, factoring is a complex technique in at least two aspects, of the debt and the transfer of credit. . Factoring is a means of financing business, especially export-import transactions, less known in Romania. Maybe because of poor business environment popularize the term is as little known as it was a few years ago the leasing. Present in Romanian legislation since 2002, factoring appears as a contract between one party (called adherent, providing goods or service and a banking company or a financial institution specialized (called factor, which the last one shall finance debts pursuing and preservation against credit risks and adherent gives factor by way of sale, debts arising from the sale of goods or services to third parties. The article is divided into three parts. In the first part we defined the concept of factoring and international factoring, then I presented the advantages and development of factoring in Romania, and the last part conclusions.

  8. Matrix factorizations and elliptic fibrations

    Science.gov (United States)

    Omer, Harun

    2016-09-01

    I use matrix factorizations to describe branes at simple singularities of elliptic fibrations. Each node of the corresponding Dynkin diagrams of the ADE-type singularities is associated with one indecomposable matrix factorization which can be deformed into one or more factorizations of lower rank. Branes with internal fluxes arise naturally as bound states of the indecomposable factorizations. Describing branes in such a way avoids the need to resolve singularities. This paper looks at gauge group breaking from E8 fibers down to SU (5) fibers due to the relevance of such fibrations for local F-theory GUT models. A purpose of this paper is to understand how the deformations of the singularity are understood in terms of its matrix factorizations. By systematically factorizing the elliptic fiber equation, this paper discusses geometries which are relevant for building semi-realistic local models. In the process it becomes evident that breaking patterns which are identical at the level of the Kodaira type of the fibers can be inequivalent at the level of matrix factorizations. Therefore the matrix factorization picture supplements information which the conventional less detailed descriptions lack.

  9. Factors associated with asthma control.

    NARCIS (Netherlands)

    Vries, M.P. de; Bemt, E.A.J.M. van den; Lince, S.; Muris, J.W.M.; Thoonen, B.P.A.; Schayck, C.P. van

    2005-01-01

    The aim of this study was to evaluate which factors are associated with asthma control experienced by asthma patients. In a cross-sectional study patients aged 16-60 years with mild to moderate asthma were selected. The influence of the following factors on asthma control was studied in a multivaria

  10. Factor analysis of multivariate data

    Digital Repository Service at National Institute of Oceanography (India)

    Fernandes, A.A.; Mahadevan, R.

    A brief introduction to factor analysis is presented. A FORTRAN program, which can perform the Q-mode and R-mode factor analysis and the singular value decomposition of a given data matrix is presented in Appendix B. This computer program, uses...

  11. Factors That Shape Design Thinking

    Science.gov (United States)

    Gray, Colin M.

    2013-01-01

    A wide range of design literature discusses the role of the studio and its related pedagogy in the development of design thinking. Scholars in a variety of design disciplines pose a number of factors that potentially affect this development process, but a full understanding of these factors as experienced from a critical pedagogy or student…

  12. Matrix factorizations and elliptic fibrations

    Directory of Open Access Journals (Sweden)

    Harun Omer

    2016-09-01

    Full Text Available I use matrix factorizations to describe branes at simple singularities of elliptic fibrations. Each node of the corresponding Dynkin diagrams of the ADE-type singularities is associated with one indecomposable matrix factorization which can be deformed into one or more factorizations of lower rank. Branes with internal fluxes arise naturally as bound states of the indecomposable factorizations. Describing branes in such a way avoids the need to resolve singularities. This paper looks at gauge group breaking from E8 fibers down to SU(5 fibers due to the relevance of such fibrations for local F-theory GUT models. A purpose of this paper is to understand how the deformations of the singularity are understood in terms of its matrix factorizations. By systematically factorizing the elliptic fiber equation, this paper discusses geometries which are relevant for building semi-realistic local models. In the process it becomes evident that breaking patterns which are identical at the level of the Kodaira type of the fibers can be inequivalent at the level of matrix factorizations. Therefore the matrix factorization picture supplements information which the conventional less detailed descriptions lack.

  13. Psychological Factors in English Study

    Institute of Scientific and Technical Information of China (English)

    吴西

    2015-01-01

    <正>1.Introduction The psychological factor that influences English study is dynamic,complex,and flexible.Its influence is not immediately known,but it rather accumulates over a period of time.It is inevitable that students have some psychological factors in learning English.Therefore,in the process of teaching,teachers

  14. Twisting formula of epsilon factors

    Indian Academy of Sciences (India)

    SAZZAD ALI BISWAS

    2017-09-01

    For characters of a non-Archimedean local field we have explicit formula for epsilon factors. But in general, we do not have any generalized twisting formula of epsilon factors. In this paper, we give a generalized twisting formula of epsilon factorsvia local Jacobi sums.

  15. Polynomial J-spectral factorization

    NARCIS (Netherlands)

    Kwakernaak, Huibert; Sebek, Michael

    1994-01-01

    Several algorithms are presented for the J-spectral factorization of a para-Hermitian polynomial matrix. The four algorithms that are discussed are based on diagonalization, successive factor extraction, interpolation, and the solution of an algebraic Riccati equation, respectively. The paper includ

  16. Kadison-Kastler stable factors

    DEFF Research Database (Denmark)

    Cameron, Jan; Christensen, Erik; Sinclair, Allan M.;

    2014-01-01

    It is proven that a pair of continuous finite von Neumann algebra factors are unitarily equivalent if sufficiently close and one satisfies a certain cohomological condition.......It is proven that a pair of continuous finite von Neumann algebra factors are unitarily equivalent if sufficiently close and one satisfies a certain cohomological condition....

  17. Quadratic prediction of factor scores

    NARCIS (Netherlands)

    Wansbeek, T

    1999-01-01

    Factor scores are naturally predicted by means of their conditional expectation given the indicators y. Under normality this expectation is linear in y but in general it is an unknown function of y. II is discussed that under nonnormality factor scores can be more precisely predicted by a quadratic

  18. Shell model and spectroscopic factors

    Energy Technology Data Exchange (ETDEWEB)

    Poves, P. [Madrid Univ. Autonoma and IFT, UAM/CSIC, E-28049 (Spain)

    2007-07-01

    In these lectures, I introduce the notion of spectroscopic factor in the shell model context. A brief review is given of the present status of the large scale applications of the Interacting Shell Model. The spectroscopic factors and the spectroscopic strength are discussed for nuclei in the vicinity of magic closures and for deformed nuclei. (author)

  19. Critical factors for EIA implementation

    DEFF Research Database (Denmark)

    Zhang, Jasmine; Kørnøv, Lone; Christensen, Per

    2013-01-01

    between different critical factors and how they relate to different stages in the EIA and thus influence the decision making process. After reviewing 33 refereed journal articles published between 1999 and 2011, we identified 203 notions of critical factors. Of these, 102 related to different stages...

  20. Shape Factor Modeling and Simulation

    Science.gov (United States)

    2016-06-01

    10 3. Shape Factor Distributions for Natural Fragments 12 3.1 Platonic Solids and Uniform Viewing from All Viewpoints 12 3.2 Natural Fragments from...12 Fig. 9 The 5 Platonic solids. ............................................................. 12 Fig. 10 Mean shape factor of...of the 5 Platonic solids............................................ 13 Table 3 Sequence of viewing angles in Icosahedron Gage