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  1. Different presentations in patients with tumor necrosis factor receptor-associated periodic syndrome mutations: report of two cases.

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    Celebi-Tayfur, Aslı; Bilginer, Yelda; Finetti, Martina; Gattorno, Marco; Ozen, Seza

    2013-01-01

    Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant autoinflammatory disorder caused by mutations in the TNFRSF1A gene encoding the 55-kDa receptor for tumor necrosis factor (TNF)-α. It is characterized by recurrent prolonged episodes of fever accompanied by abdominal pain, pleuritis, migratory skin rashes, fasciitis, headache, conjunctivitis, and periorbital edema. We report two children, one with a severe mutation in the TNFRSF1A gene causing the typical phenotype. The second patient had a homozygous R92Q-type mutation and displayed a periodic fever with aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome-like phenotype. In the eastern Mediterranean region, TRAPS is probably underdiagnosed because of the overwhelming frequency of familial Mediterranean fever (FMF). However, TRAPS should be sought for in patients with atypical symptoms for FMF.

  2. Familial clustering of recurrent pericarditis may disclose tumour necrosis factor receptor-associated periodic syndrome.

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    Cantarini, Luca; Lucherini, Orso Maria; Baldari, Cosima Tatiana; Laghi Pasini, Franco; Galeazzi, Mauro

    2010-01-01

    Although several causes of recurrent pericarditis have been identified, the etiology remains obscure in most cases. The tumour necrosis factor receptor-1 associated periodic syndrome (TRAPS) is the most common autosomal dominant autoinflammatory disorder and is caused by mutations in the TNFRSF1A gene encoding the 55-kD receptor for tumour necrosis factor-(TNF)-alpha. Serosal membrane inflammation is a common feature of TRAPS, usually in the form of polyserositis. In addition, patients affected with recurrent pericarditis as the only clinical manifestation of TRAPS have been recently described. Our aim was to investigate the possible involvement of mutations in the TNFRSF1A gene in a cohort of patients affected with idiopathic recurrent pericarditis. Twenty consecutive patients diagnosed with idiopathic recurrent pericarditis were enrolled. Each patient underwent detailed examinations in order to rule out underlying diseases such as infections, connective tissue disorders and malignancies, and mutations of the TNFRSF1A gene were searched for by amplifying, using polymerase chain reaction (PCR), genomic DNA, and direct sequencing. TNFRSF1A mutations were found in 2 of the 20 patients. They were siblings, and they both carried a heterozygous low-penetrance R92Q mutation in the TNFRSF1A gene. Familial clustering has been recently reported in up to 10% of patients with recurrent pericarditis, thus suggesting in some cases a possible genetic predisposition. Our study suggests that familial clustering may represent a clue for investigating mutations in the TNFRSF1A gene in these patients and eventually disclose TRAPS.

  3. Overlap syndrome between Familial Mediterranean fever and tumor necrosis factor receptor-associated periodic syndrome in a lupus patient.

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    Nonaka, Fumiaki; Migita, Kiyoshi; Iwasaki, Keisuke; Shimizu, Toshimasa; Kawakami, Atsushi; Yasunami, Michio; Eguchi, Katsumi

    2014-06-01

    Autoinflammatory diseases represent an expanding spectrum of genetic and non-genetic inflammatory diseases characterized by recurrent episodes of fever and systemic inflammation, affecting joints, skin and serosal surfaces. Familial Mediterranean fever (FMF) is the most common autosomal recessive hereditary autoinflammatory disease. Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant hereditary autoinflammatory disease. They share some clinical manifestations such as a periodic fever and skin rash. We present here the association of FMF with TRAPS in a systemic lupus erythematosus (SLE) patient. A 54-year-old SLE patient with recurrent attacks of fever, arthritis, and skin rashes was referred to our hospital. She had been diagnosed with lupus nephritis at 19 years old. Her lupus nephritis was controlled by steroid treatments; however, since childhood she has suffered from recurrent episodes of periodic fever, abdominal pain, arthritis, and erythematous skin rashes. An initial diagnosis of FMF was suspected based on the genetic analysis, showing the compound heterozygous L110P/E148Q mutations in the MEFV gene that is responsible for FMF. Her symptoms responded to colchicine, but the febrile attacks were not completely resolved. Therefore, genetic testing for TRAPS was performed. The results revealed a heterozygous T61I mutation in the TNFRSF1A gene that encodes tumor necrosis factor-α receptor and is responsible for TRAPS. The patient was diagnosed with overlapping FMF and TRAPS, in addition to SLE. This is the first report of SLE associated with both FMF and TRAPS.

  4. Novel mutation identified in severe early-onset tumor necrosis factor receptor-associated periodic syndrome: a case report.

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    Radhakrishna, Suhas M; Grimm, Amy; Broderick, Lori

    2017-04-20

    Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS) is the second most common heritable autoinflammatory disease, typically presenting in pre-school aged children with fever episodes lasting 1-3 weeks. Systemic symptoms can include rash, myalgia, ocular inflammation, and serositis. Here we report an unusual presentation of TRAPS in a 7 month old girl who presented with only persistent fever. She was initially diagnosed with incomplete Kawasaki Disease and received IVIG and infliximab; however, her fevers quickly recurred. Subsequent testing revealed a urinary tract infection, but she did not improve despite appropriate therapy. As fever continued, she developed significant abdominal distension with imaging concerning for appendicitis, followed by hyperthermia and hemodynamic instability. Given her protracted clinical course and maternal history of a poorly defined inflammatory condition, an autoinflammatory disease was considered. Therapy with anakinra was initiated, resulting in rapid resolution of fever and normalization of inflammatory markers. She was found to have a previously unreported mutation, Thr90Pro, in the TNFRSF1A gene associated with TRAPS. This novel mutation was also confirmed in the patient's mother and maternal uncle. This report reviews a severe case of TRAPS in infancy associated with a novel mutation, Thr90Pro, in the TNFRSF1A gene, and emphasizes that autoinflammatory disease should be considered in the differential of infants with fever of unknown origin.

  5. First report of circulating microRNAs in tumour necrosis factor receptor-associated periodic syndrome (TRAPS.

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    Orso Maria Lucherini

    Full Text Available Tumor necrosis factor-receptor associated periodic syndrome (TRAPS is a rare autosomal dominant autoinflammatory disorder characterized by recurrent episodes of long-lasting fever and inflammation in different regions of the body, such as the musculo-skeletal system, skin, gastrointestinal tract, serosal membranes and eye. Our aims were to evaluate circulating microRNAs (miRNAs levels in patients with TRAPS, in comparison to controls without inflammatory diseases, and to correlate their levels with parameters of disease activity and/or disease severity. Expression levels of circulating miRNAs were measured by Agilent microarrays in 29 serum samples from 15 TRAPS patients carrying mutations known to be associated with high disease penetrance and from 8 controls without inflammatory diseases. Differentially expressed and clinically relevant miRNAs were detected using GeneSpring GX software. We identified a 6 miRNAs signature able to discriminate TRAPS from controls. Moreover, 4 miRNAs were differentially expressed between patients treated with the interleukin (IL-1 receptor antagonist, anakinra, and untreated patients. Of these, miR-92a-3p and miR-150-3p expression was found to be significantly reduced in untreated patients, while their expression levels were similar to controls in samples obtained during anakinra treatment. MiR-92b levels were inversely correlated with the number of fever attacks/year during the 1(st year from the index attack of TRAPS, while miR-377-5p levels were positively correlated with serum amyloid A (SAA circulating levels. Our data suggest that serum miRNA levels show a baseline pattern in TRAPS, and may serve as potential markers of response to therapeutic intervention.

  6. First Report of Circulating MicroRNAs in Tumour Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS)

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    Ferracin, Manuela; Fulci, Valerio; McDermott, Michael F.; Merlini, Giampaolo; Muscari, Isabella; Magnotti, Flora; Dickie, Laura J.; Galeazzi, Mauro; Negrini, Massimo; Baldari, Cosima Tatiana; Cimaz, Rolando; Cantarini, Luca

    2013-01-01

    Tumor necrosis factor-receptor associated periodic syndrome (TRAPS) is a rare autosomal dominant autoinflammatory disorder characterized by recurrent episodes of long-lasting fever and inflammation in different regions of the body, such as the musculo-skeletal system, skin, gastrointestinal tract, serosal membranes and eye. Our aims were to evaluate circulating microRNAs (miRNAs) levels in patients with TRAPS, in comparison to controls without inflammatory diseases, and to correlate their levels with parameters of disease activity and/or disease severity. Expression levels of circulating miRNAs were measured by Agilent microarrays in 29 serum samples from 15 TRAPS patients carrying mutations known to be associated with high disease penetrance and from 8 controls without inflammatory diseases. Differentially expressed and clinically relevant miRNAs were detected using GeneSpring GX software. We identified a 6 miRNAs signature able to discriminate TRAPS from controls. Moreover, 4 miRNAs were differentially expressed between patients treated with the interleukin (IL)-1 receptor antagonist, anakinra, and untreated patients. Of these, miR-92a-3p and miR-150-3p expression was found to be significantly reduced in untreated patients, while their expression levels were similar to controls in samples obtained during anakinra treatment. MiR-92b levels were inversely correlated with the number of fever attacks/year during the 1st year from the index attack of TRAPS, while miR-377-5p levels were positively correlated with serum amyloid A (SAA) circulating levels. Our data suggest that serum miRNA levels show a baseline pattern in TRAPS, and may serve as potential markers of response to therapeutic intervention. PMID:24066048

  7. Tumor necrosis factor receptor-associated periodic syndrome (TRAPS): definition, semiology, prognosis, pathogenesis, treatment, and place relative to other periodic joint diseases.

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    Masson, Charles; Simon, Virginie; Hoppé, Emmanuel; Insalaco, Paolo; Cissé, Idrissa; Audran, Maurice

    2004-07-01

    Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal dominant inherited condition of periodic fever and pain. Most patients are of northern European descent. The attacks manifest as fever and pain in the joints, abdomen, muscles, skin, or eyes, with variations across patients. An acute-phase response occurs during the attacks. Patients with TRAPS are at risk for AA amyloidosis, the most common targets being the kidneys and liver. Soluble TNFRSF1A is usually low between the attacks and may be normal during the attacks, when TNF levels are high. TNFRSF1A is found in abnormally high numbers on leukocyte cell membranes. TRAPS is the first condition for which naturally occurring mutations in a TNF receptor were found; the mutations affect the soluble TNFRSF1A gene in the 12p13 region. In some patients, the pathogenesis involves defective TNFRSF1A shedding from cell membranes in response to a given stimulus. Thus, TRAPS is a model for a novel pathogenic concept characterized by failure to shed a cytokine receptor. This review compares TRAPS to other inherited periodic febrile conditions, namely, familial Mediterranean fever, Muckle-Wells syndrome, cold urticaria, and hyper-IgD syndrome. The place of TRAPS relative to other intermittent systemic joint diseases is discussed. Colchicine neither relieves nor prevents the attacks, whereas oral glucocorticoid therapy is effective when used in dosages greater than 20 mg/day. The pathogenic hypothesis involving defective TNFRSF1A shedding suggests that medications targeting TNF may be effective in TRAPS.

  8. International Retrospective Chart Review of Treatment Patterns in Severe Familial Mediterranean Fever, Tumor Necrosis Factor Receptor-Associated Periodic Syndrome, and Mevalonate Kinase Deficiency/Hyperimmunoglobulinemia D Syndrome.

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    Ozen, Seza; Kuemmerle-Deschner, Jasmin B; Cimaz, Rolando; Livneh, Avi; Quartier, Pierre; Kone-Paut, Isabelle; Zeft, Andrew; Spalding, Steve; Gul, Ahmet; Hentgen, Veronique; Savic, Sinisa; Foeldvari, Ivan; Frenkel, Joost; Cantarini, Luca; Patel, Dony; Weiss, Jeffrey; Marinsek, Nina; Degun, Ravi; Lomax, Kathleen G; Lachmann, Helen J

    2017-04-01

    Periodic fever syndrome (PFS) conditions are characterized by recurrent attacks of fever and localized inflammation. This study examined the diagnostic pathway and treatments at tertiary centers for familial Mediterranean fever (FMF), tumor necrosis factor receptor-associated periodic syndrome (TRAPS), and mevalonate kinase deficiency (MKD)/hyperimmunoglobulinemia D syndrome (HIDS). PFS specialists at medical centers in the US, the European Union, and the eastern Mediterranean participated in a retrospective chart review, providing de-identified data in an electronic case report form. Patients were treated between 2008 and 2012, with at least 1 year of followup; all had clinical and/or genetically proven disease and were on/eligible for biologic treatment. A total of 134 patients were analyzed: FMF (n = 49), TRAPS (n = 47), and MKD/HIDS (n = 38). Fever was commonly reported as severe across all indications. Other frequently reported severe symptoms were serositis for FMF patients and elevated acute-phase reactants and gastrointestinal upset for TRAPS and MKD/HIDS. A long delay from disease onset to diagnosis was seen within TRAPS and MKD/HIDS (5.8 and 7.1 years, respectively) compared to a 1.8-year delay in FMF patients. An equal proportion of TRAPS patients first received anti-interleukin-1 (anti-IL-1) and anti-tumor necrosis factor (anti-TNF) biologic agents, whereas IL-1 blockade was the main choice for FMF patients resistant to colchicine and MKD/HIDS patients. For TRAPS patients, treatment with anakinra versus anti-TNF treatments as first biologic agent resulted in significantly higher clinical and biochemical responses (P = 0.03 and P < 0.01, respectively). No significant differences in responses were observed between biologic agents among other cohorts. Referral patterns and diagnostic delays highlight the need for greater awareness and improved diagnostics for PFS. This real-world treatment assessment supports the need for further

  9. Typical and severe tumor necrosis factor receptor-associated periodic syndrome in the absence of mutations in the TNFRSF1A gene: a case series.

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    Cantarini, Luca; Lucherini, Orso Maria; Cimaz, Rolando; Rigante, Donato; Baldari, Cosima Tatiana; Laghi Pasini, Franco; Galeazzi, Mauro

    2012-12-01

    Tumor necrosis factor receptor-1-associated periodic syndrome (TRAPS) is the most common autosomal dominant autoinflammatory disorder and is caused by mutations in the TNFRSF1A gene encoding the 55-kDa receptor for tumor necrosis factor (TNF)-α. TRAPS is characterized by recurrent attacks of fever, typically lasting from 1 to 3 weeks. In addition to fever, common clinical features include periorbital edema, a migratory erythematous plaque simulating erysipela with underlying myalgia, and arthralgia or arthritis. Serosal membrane inflammation is also a common feature, usually in the form of polyserositis. To date, at least 40 different TNFRSF1A mutations have been identified, but few patients with symptoms highly suggestive of TRAPS with no mutations in the TNFRSF1A gene have recently been described, thus suggesting that not all mutations are yet known or that alternative mechanisms might be involved in the pathogenesis of the disease. We report on three such patients here.

  10. [Molecular diagnostics of hereditary fever syndromes. Familial Mediterranean fever (FMF), hyperimmunoglobulin D syndrome (HIDS), tumor necrosis factor receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS: FCAS, MWS, NOMID/CINCA)].

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    Timmann, C; Horstmann, R

    2009-11-01

    Periodic episodes of fever and inflammation can have a genetic origin. Nowadays, the identification of the causative genetic variants in the majority of cases allows molecular genetic confirmation of the clinical diagnosis, which enables approaches with specific drug treatment and improves patient compliance as well as genetic counseling. Besides a detailed clinical examination a medical history including family history and an assessment of the ethnic origin are required. In order to make genetic testing straightforward and cost effective an iterative procedure should be followed which should include, in addition to clinical data, the frequencies of causative mutations in the various gene segments involved.

  11. Tumor necrosis factor receptor-associated factor 3 is a positive regulator of pathological cardiac hypertrophy.

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    Jiang, Xi; Deng, Ke-Qiong; Luo, Yuxuan; Jiang, Ding-Sheng; Gao, Lu; Zhang, Xiao-Fei; Zhang, Peng; Zhao, Guang-Nian; Zhu, Xueyong; Li, Hongliang

    2015-08-01

    Cardiac hypertrophy, a common early symptom of heart failure, is regulated by numerous signaling pathways. Here, we identified tumor necrosis factor receptor-associated factor 3 (TRAF3), an adaptor protein in tumor necrosis factor-related signaling cascades, as a key regulator of cardiac hypertrophy in response to pressure overload. TRAF3 expression was upregulated in hypertrophied mice hearts and failing human hearts. Four weeks after aortic banding, cardiac-specific conditional TRAF3-knockout mice exhibited significantly reduced cardiac hypertrophy, fibrosis, and dysfunction. Conversely, transgenic mice overexpressing TRAF3 in the heart developed exaggerated cardiac hypertrophy in response to pressure overload. TRAF3 also promoted an angiotensin II- or phenylephrine-induced hypertrophic response in isolated cardiomyocytes. Mechanistically, TRAF3 directly bound to TANK-binding kinase 1 (TBK1), causing increased TBK1 phosphorylation in response to hypertrophic stimuli. This interaction between TRAF3 and TBK1 further activated AKT signaling, which ultimately promoted the development of cardiac hypertrophy. Our findings not only reveal a key role of TRAF3 in regulating the hypertrophic response but also uncover TRAF3-TBK1-AKT as a novel signaling pathway in the development of cardiac hypertrophy and heart failure. This pathway may represent a potential therapeutic target for this pathological process.

  12. MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis

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    Guo, Li-Juan; Liao, Lan [Department of Endocrinology, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, Hunan 410008 (China); Yang, Li [Department of Endocrinology, Hunan Province Geriatric Hospital, Changsha, Hunan 410001 (China); Li, Yu [Department of Endocrinology, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, Hunan 410008 (China); Jiang, Tie-Jian, E-mail: jiangtiejian@gmail.com [Department of Endocrinology, Xiangya Hospital of Central South University, 87 Xiangya Road, Changsha, Hunan 410008 (China)

    2014-02-15

    MicroRNAs (miRNAs) play important roles in osteoclastogenesis and bone resorption. In the present study, we found that miR-125a was dramatically down-regulated during macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ligand (RANKL) induced osteoclastogenesis of circulating CD14+ peripheral blood mononuclear cells (PBMCs). Overexpression of miR-125a in CD14+ PBMCs inhibited osteoclastogenesis, while inhibition of miR-125a promoted osteoclastogenesis. TNF receptor-associated factor 6 (TRAF6), a transduction factor for RANKL/RANK/NFATc1 signal, was confirmed to be a target of miR-125a. EMSA and ChIP assays confirmed that NFATc1 bound to the promoter of the miR-125a. Overexpression of NFATc1 inhibited miR-125a transcription, and block of NFATc1 expression attenuated RANKL-regulated miR-125a transcription. Here, we reported that miR-125a played a biological function in osteoclastogenesis through a novel TRAF6/ NFATc1/miR-125a regulatory feedback loop. It suggests that regulation of miR-125a expression may be a potential strategy for ameliorating metabolic disease. - Highlights: • MiR-125a was significantly down-regulated in osteoclastogenesis of CD14+ PBMCs. • MiR-125a inhibited osteoclast differentiation by targeting TRAF6. • NFATc1 inhibited miR-125a transciption by binding to the promoter of miR-125a. • TRAF6/NFATc1 and miR-125a form a regulatory feedback loop in osteoclastogenesis.

  13. Tumor necrosis factor receptor-associated protein 1 improves hypoxia-impaired energy production in cardiomyocytes through increasing activity of cytochrome c oxidase subunit II.

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    Xiang, Fei; Ma, Si-Yuan; Zhang, Dong-Xia; Zhang, Qiong; Huang, Yue-Sheng

    2016-10-01

    Tumor necrosis factor receptor-associated protein 1 protects cardiomyocytes against hypoxia, but the underlying mechanisms are not completely understood. In the present study, we used gain- and loss-of-function approaches to explore the effects of tumor necrosis factor receptor-associated protein 1 and cytochrome c oxidase subunit II on energy production in hypoxic cardiomyocytes. Hypoxia repressed ATP production in cultured cardiomyocytes, whereas overexpression of tumor necrosis factor receptor-associated protein 1 significantly improved ATP production. Conversely, knockdown of tumor necrosis factor receptor-associated protein 1 facilitated the hypoxia-induced decrease in ATP synthesis. Further investigation revealed that tumor necrosis factor receptor-associated protein 1 induced the expression and activity of cytochrome c oxidase subunit II, a component of cytochrome c oxidase that is important in mitochondrial respiratory chain function. Moreover, lentiviral-mediated overexpression of cytochrome c oxidase subunit II antagonized the decrease in ATP synthesis caused by knockdown of tumor necrosis factor receptor-associated protein 1, whereas knockdown of cytochrome c oxidase subunit II attenuated the increase in ATP synthesis caused by overexpression of tumor necrosis factor receptor-associated protein 1. In addition, inhibition of cytochrome c oxidase subunit II by a specific inhibitor sodium azide suppressed the ATP sy nthesis induced by overexpressed tumor necrosis factor receptor-associated protein 1. Hence, tumor necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxia at least partly via potentiation of energy generation, and cytochrome c oxidase subunit II is one of the downstream effectors that mediates the tumor necrosis factor receptor-associated protein 1-mediated energy generation program.

  14. Canakinumab treatment for patients with active recurrent or chronic TNF receptor-associated periodic syndrome (TRAPS): an open-label, phase II study

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    Gattorno, Marco; Obici, Laura; Cattalini, Marco; Tormey, Vincent; Abrams, Ken; Davis, Nicole; Speziale, Antonio; Bhansali, Suraj G; Martini, Alberto; Lachmann, Helen J

    2017-01-01

    Objective To evaluate the efficacy of canakinumab, a high-affinity human monoclonal anti-interleukin-1β antibody, in inducing complete or almost complete responses in patients with active tumour necrosis factor receptor-associated periodic syndrome (TRAPS). Methods Twenty patients (aged 7–78 years) with active recurrent or chronic TRAPS were treated with canakinumab 150 mg every 4 weeks for 4 months (2 mg/kg for those ≤40 kg) in this open-label, proof-of-concept, phase II study. Canakinumab was then withdrawn for up to 5 months, with reintroduction on relapse, and 4 weekly administration (subsequently increased to every 8 weeks) for 24 months. The primary efficacy variable was the proportion of patients achieving complete or almost complete response at day 15, defined as clinical remission (Physician's Global Assessment score ≤1) and full or partial serological remission. Results Nineteen patients (19/20, 95%; 95% CI 75.1% to 99.9%) achieved the primary efficacy variable. Responses to canakinumab occurred rapidly; median time to clinical remission 4 days (95% CI 3 to 8 days). All patients relapsed after canakinumab was withdrawn; median time to relapse 91.5 days (95% CI 65 to 117 days). On reintroduction of canakinumab, clinical and serological responses were similar to those seen during the first phase, and were sustained throughout treatment. Canakinumab was well tolerated and clinical responses were accompanied by rapid and sustained improvement in health-related quality of life. Weight normalised pharmacokinetics of canakinumab, although limited, appeared to be consistent with historical canakinumab data. Conclusions Canakinumab induces rapid disease control in patients with active TRAPS, and clinical benefits are sustained during long-term treatment. Trial registration number NCT01242813; Results. PMID:27269295

  15. Lansoprazole Upregulates Polyubiquitination of the TNF Receptor-Associated Factor 6 and Facilitates Runx2-mediated Osteoblastogenesis

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    Kenichi Mishima

    2015-12-01

    Full Text Available The transcription factor, runt-related transcription factor 2 (Runx2, plays a pivotal role in the differentiation of the mesenchymal stem cells to the osteochondroblast lineages. We found by the drug repositioning strategy that a proton pump inhibitor, lansoprazole, enhances nuclear accumulation of Runx2 and induces osteoblastogenesis of human mesenchymal stromal cells. Systemic administration of lansoprazole to a rat femoral fracture model increased osteoblastogenesis. Dissection of signaling pathways revealed that lansoprazole activates a noncanonical bone morphogenic protein (BMP-transforming growth factor-beta (TGF-β activated kinase-1 (TAK1–p38 mitogen-activated protein kinase (MAPK pathway. We found by in cellulo ubiquitination studies that lansoprazole enhances polyubiquitination of the TNF receptor-associated factor 6 (TRAF6 and by in vitro ubiquitination studies that the enhanced polyubiquitination of TRAF6 is attributed to the blocking of a deubiquitination enzyme, cylindromatosis (CYLD. Structural modeling and site-directed mutagenesis of CYLD demonstrated that lansoprazole tightly fits in a pocket of CYLD where the C-terminal tail of ubiquitin lies. Lansoprazole is a potential therapeutic agent for enhancing osteoblastic differentiation.

  16. The enteropathogenic E. coli (EPEC Tir effector inhibits NF-κB activity by targeting TNFα receptor-associated factors.

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    Marie-Hélène Ruchaud-Sparagano

    2011-12-01

    Full Text Available Enteropathogenic Escherichia coli (EPEC disease depends on the transfer of effector proteins into epithelia lining the human small intestine. EPEC E2348/69 has at least 20 effector genes of which six are located with the effector-delivery system genes on the Locus of Enterocyte Effacement (LEE Pathogenicity Island. Our previous work implied that non-LEE-encoded (Nle effectors possess functions that inhibit epithelial anti-microbial and inflammation-inducing responses by blocking NF-κB transcription factor activity. Indeed, screens by us and others have identified novel inhibitory mechanisms for NleC and NleH, with key co-operative functions for NleB1 and NleE1. Here, we demonstrate that the LEE-encoded Translocated-intimin receptor (Tir effector has a potent and specific ability to inhibit NF-κB activation. Indeed, biochemical, imaging and immunoprecipitation studies reveal a novel inhibitory mechanism whereby Tir interaction with cytoplasm-located TNFα receptor-associated factor (TRAF adaptor proteins induces their proteasomal-independent degradation. Infection studies support this Tir-TRAF relationship but reveal that Tir, like NleC and NleH, has a non-essential contribution in EPEC's NF-κB inhibitory capacity linked to Tir's activity being suppressed by undefined EPEC factors. Infections in a disease-relevant intestinal model confirm key NF-κB inhibitory roles for the NleB1/NleE1 effectors, with other studies providing insights on host targets. The work not only reveals a second Intimin-independent property for Tir and a novel EPEC effector-mediated NF-κB inhibitory mechanism but also lends itself to speculations on the evolution of EPEC's capacity to inhibit NF-κB function.

  17. Genetics Home Reference: tumor necrosis factor receptor-associated periodic syndrome

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    ... can have additional signs and symptoms. These include abdominal and muscle pain and a spreading skin rash, typically found ... occur? How can gene mutations affect health and development? More about Mutations and Health Inheritance Pattern This ...

  18. Molecular characterization and functional analysis of tumor necrosis factor receptor-associated factor 2 in the Pacific oyster.

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    Huang, Baoyu; Zhang, Linlin; Du, Yishuai; Li, Li; Tang, Xueying; Zhang, Guofan

    2016-01-01

    Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of crucial adaptors, playing vital roles in mediating signal transduction in immune signaling pathways, including RIG-I-like receptor (RLR) signaling pathway. In the present study, a new TRAF family member (CgTRAF2) was identified in the Pacific oyster, Crassostrea gigas. Comparison and phylogenetic analysis revealed that CgTRAF2 could be a new member of the invertebrate TRAF2 family. Quantitative real-time PCR revealed that CgTRAF2 mRNA was highly expressed in the digestive gland, gills, and hemocytes, and it was significantly up-regulated after Vibrio alginolyticus and ostreid herpesvirus 1 (OsHV-1) challenge. The CgTRAF2 mRNA expression profile in different developmental stages of oyster larvae suggested that CgTRAF2 could function in early larval development. CgTRAF2 mRNA expression pattern, after the silence of CgMAVS (Mitochondrial Antiviral Signaling) -like, indicated that CgTRAF2 might function downstream of CgMAVS-like. Moreover, the subcellular localization analysis revealed that CgTRAF2 was localized in cytoplasm, and it may play predominately important roles in signal transduction. Collectively, these results demonstrated that CgTRAF2 might play important roles in the innate immunity and larval development of the Pacific oyster.

  19. Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Associates with Huntingtin Protein and Promotes Its Atypical Ubiquitination to Enhance Aggregate Formation*

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    Zucchelli, Silvia; Marcuzzi, Federica; Codrich, Marta; Agostoni, Elena; Vilotti, Sandra; Biagioli, Marta; Pinto, Milena; Carnemolla, Alisia; Santoro, Claudio; Gustincich, Stefano; Persichetti, Francesca

    2011-01-01

    Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of polyglutamines in the first exon of huntingtin (HTT), which confers aggregation-promoting properties to amino-terminal fragments of the protein (N-HTT). Mutant N-HTT aggregates are enriched for ubiquitin and contain ubiquitin E3 ligases, thus suggesting a role for ubiquitination in aggregate formation. Here, we report that tumor necrosis factor receptor-associated factor 6 (TRAF6) binds to WT and polyQ-expanded N-HTT in vitro as well as to endogenous full-length proteins in mouse and human brain in vivo. Endogenous TRAF6 is recruited to cellular inclusions formed by mutant N-HTT. Transient overexpression of TRAF6 promotes WT and mutant N-HTT atypical ubiquitination with Lys6, Lys27, and Lys29 linkage formation. Both interaction and ubiquitination seem to be independent from polyQ length. In cultured cells, TRAF6 enhances mutant N-HTT aggregate formation, whereas it has no effect on WT N-HTT protein localization. Mutant N-HTT inclusions are enriched for ubiquitin staining only when TRAF6 and Lys6, Lys27, and Lys29 ubiquitin mutants are expressed. Finally, we show that TRAF6 is up-regulated in post-mortem brains from HD patients where it is found in the insoluble fraction. These results suggest that TRAF6 atypical ubiquitination warrants investigation in HD pathogenesis. PMID:21454471

  20. Tumor necrosis factor receptor-associated factor 6 (TRAF6) associates with huntingtin protein and promotes its atypical ubiquitination to enhance aggregate formation.

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    Zucchelli, Silvia; Marcuzzi, Federica; Codrich, Marta; Agostoni, Elena; Vilotti, Sandra; Biagioli, Marta; Pinto, Milena; Carnemolla, Alisia; Santoro, Claudio; Gustincich, Stefano; Persichetti, Francesca

    2011-07-15

    Huntington disease (HD) is a neurodegenerative disorder caused by an expansion of polyglutamines in the first exon of huntingtin (HTT), which confers aggregation-promoting properties to amino-terminal fragments of the protein (N-HTT). Mutant N-HTT aggregates are enriched for ubiquitin and contain ubiquitin E3 ligases, thus suggesting a role for ubiquitination in aggregate formation. Here, we report that tumor necrosis factor receptor-associated factor 6 (TRAF6) binds to WT and polyQ-expanded N-HTT in vitro as well as to endogenous full-length proteins in mouse and human brain in vivo. Endogenous TRAF6 is recruited to cellular inclusions formed by mutant N-HTT. Transient overexpression of TRAF6 promotes WT and mutant N-HTT atypical ubiquitination with Lys(6), Lys(27), and Lys(29) linkage formation. Both interaction and ubiquitination seem to be independent from polyQ length. In cultured cells, TRAF6 enhances mutant N-HTT aggregate formation, whereas it has no effect on WT N-HTT protein localization. Mutant N-HTT inclusions are enriched for ubiquitin staining only when TRAF6 and Lys(6), Lys(27), and Lys(29) ubiquitin mutants are expressed. Finally, we show that TRAF6 is up-regulated in post-mortem brains from HD patients where it is found in the insoluble fraction. These results suggest that TRAF6 atypical ubiquitination warrants investigation in HD pathogenesis.

  1. [Mechanism of protective effects of tumor necrosis factor receptor associated protein 1 on hypoxic cardiomyocytes of rats].

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    Xiang, F; Zhang, D X; Ma, S Y; Huang, Y S

    2016-12-20

    Objective: To investigate the mechanism of protective effects of tumor necrosis factor receptor associated protein 1 (TRAP1) on hypoxic cardiomyocytes of rats. Methods: Primary cultured cardiomyocytes were obtained from neonatal Sprague-Dawley rats (aged 1 to 3 days) and then used in the following experiments. (1) Cells were divided into group TRAP1 and control group according to the random number table (the same grouping method below), and then the total protein of cells was extracted. Total protein of cells in group TRAP1 was added with mouse anti-rat TRAP1 monoclonal antibody, while that in control group was added with the same type of IgG from mouse. Co-immunoprecipitation and protein mass spectrography analysis were used to determine the possible proteins interacted with TRAP1. (2) Cells were divided into normoxia blank control group (NBC), normoxia+ TRAP1 interference control group (NTIC), normoxia+ TRAP1 interference group (NTI), normoxia+ TRAP1 over-expression control group (NTOC), and normoxia+ TRAP1 over-expression group (NTO), with 1 well in each group. Cells in group NBC were routinely cultured, while cells in the latter four groups were respectively added with TRAP1 RNA interference empty virus vector, TRAP1 RNA interference adenovirus vector, TRAP1 over-expression empty virus vector, and TRAP1 over-expression adenovirus vector. Another batch of cells were divided into group NBC, hypoxic blank control group (HBC), hypoxic+ TRAP1 interference control group (HTIC), hypoxic+ TRAP1 interference group (HTI), hypoxic+ TRAP1 over-expression control group (HTOC), and hypoxic+ TRAP1 over-expression group (HTO), with 1 well in each group. Cells in hypoxic groups were under hypoxic condition for 6 hours after being treated as those in the corresponding normoxia groups, respectively. The mRNA expression of cytochrome c oxidase subunit Ⅱ (COXⅡ) of cells in each group was detected by real time fluorescent quantitive reverse transcription polymerase chain

  2. Citrobacter rodentium NleB Protein Inhibits Tumor Necrosis Factor (TNF) Receptor-associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production.

    Science.gov (United States)

    Gao, Xiaofei; Pham, Thanh H; Feuerbacher, Leigh Ann; Chen, Kangming; Hays, Michael P; Singh, Gyanendra; Rueter, Christian; Hurtado-Guerrero, Ramon; Hardwidge, Philip R

    2016-08-26

    Interferon signaling plays important roles in both intestinal homeostasis and in the host response to pathogen infection. The extent to which bacterial pathogens inhibit this host pathway is an understudied area of investigation. We characterized Citrobacter rodentium strains bearing deletions in individual type III secretion system effector genes to determine whether this pathogen inhibits the host type I IFN response and which effector is responsible. The NleB effector limited host IFN-β production by inhibiting Lys(63)-linked ubiquitination of TNF receptor-associated factor 3 (TRAF3). Inhibition was dependent on the glycosyltransferase activity of NleB. GAPDH, a target of NleB during infection, bound to TRAF3 and was required for maximal TRAF3 ubiquitination. NleB glycosyltransferase activity inhibited GAPDH-TRAF3 binding, resulting in reduced TRAF3 ubiquitination. Collectively, our data reveal important interplay between GAPDH and TRAF3 and suggest a mechanism by which the NleB effector inhibits type I IFN signaling.

  3. Impact of the Tumor Necrosis Factor Receptor-Associated Protein 1 (Trap1) on Renal DNaseI Shutdown and on Progression of Murine and Human Lupus Nephritis

    DEFF Research Database (Denmark)

    Fismen, Silje; Thiyagarajan, Dhivya; Seredkina, Natalya

    2013-01-01

    electron microscopy, IHC, and in situ hybridization. Data indicate that silencing of DNaseI gene expression correlates inversely with expression of the Trap1 gene. Our observations suggest that the mouse model is relevant for the aspects of disease progression in human lupus nephritis. Acquired silencing...... basement membranes where they appear in complex with IgG antibodies. Here, we implicate the anti-apoptotic and survival protein, tumor necrosis factor receptor-associated protein 1 (Trap1) in the disease process, based on the observation that annotated transcripts from this gene overlap with transcripts...... from the DNaseI gene. Furthermore, we translate these observations to human lupus nephritis. In this study, mouse and human DNaseI and Trap1 mRNA levels were determined by quantitative PCR and compared with protein expression levels and clinical data. Cellular localization was analyzed by immune...

  4. Molecular cloning, expression and functional characterization of tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) in grass carp, Ctenopharyngodon idella.

    Science.gov (United States)

    Lu, R-H; Chang, Z-G; Sun, J; Yang, F; Nie, G-X; Ji, H

    2016-10-01

    TRIP (Tumor Necrosis Factor (TNF) Receptor-Associated Factor (TRAF)-Interacting Protein), a member of the TNF superfamily, plays a crucial role in the modulation of inflammation in vertebrates. However, no information about TRIP is available in teleosts. In this study, the full-length cDNA of TRIP, containing a 5'UTR of 112 bp, an ORF of 1359 bp, and a 3'UTR of 29 bp before the poly (A) tail, was cloned from grass carp, Ctenopharyngodon idella. The TRIP gene encoded a protein of 452 amino acids with an estimated molecular mass of 51.06 KD and a predicted theoretical isoelectric point (pI) of 9.11. Quantitative real-time PCR analysis revealed that TRIP mRNA was expressed in all the tissues examined in grass carp, with the highest expression in the kidney, followed by the intestine and thymus. However, lower levels of expression were also detected in fat, spleen, liver, gonad and heart. Subcellular localization and two-hybrid analysis revealed that TRIP was located in the nucleus and that it interacted with TRAF1 and TRAF2 in HEK293T cells. Furthermore, similar to TNF-α, IL-10 and TRIP mRNA expression was upregulated in the spleen of fish fed high-fat or high-carbohydrate diets, suggesting that TRIP might be associated with the response to excessive energy intake. The mRNA relative expression of TRIP was significantly reduced (P < 0.05) after hepatocyte of C. idella was treated with 2 μg/mL lipopolysaccharide (LPS) for 4 h, while the expression levels of inflammatory cytokines TNF-α and IL-10 were significantly increased (P < 0.05). Taken together, these results indicate that TRIP might play important roles in immune defense and has the potential to be used as a anti-inflammation target in grass carp.

  5. TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.

    Science.gov (United States)

    Pype, S; Declercq, W; Ibrahimi, A; Michiels, C; Van Rietschoten, J G; Dewulf, N; de Boer, M; Vandenabeele, P; Huylebroeck, D; Remacle, J E

    2000-06-16

    CD40 belongs to the tumor necrosis factor (TNF) receptor family. CD40 signaling involves the recruitment of TNF receptor-associated factors (TRAFs) to its cytoplasmic domain. We have identified a novel intracellular CD40-binding protein termed TRAF and TNF receptor-associated protein (TTRAP) that also interacts with TNF-R75 and CD30. The region of the CD40 cytoplasmic domain that is required for TTRAP association overlaps with the TRAF6 recognition motif. Association of TTRAP with CD40 increases profoundly in response to treatment of cells with CD40L. Interestingly, TTRAP also associates with TRAFs, with the highest affinity for TRAF6. In transfected cells, TTRAP inhibits in a dose-dependent manner the transcriptional activation of a nuclear factor-kappaB (NF-kappaB)-dependent reporter mediated by CD40, TNF-R75 or Phorbol 12-myristate 13-acetate (PMA) and to a lesser extent by TRAF2, TRAF6, TNF-alpha, or interleukin-1beta (IL-1beta). TTRAP does not affect stimulation of NF-kappaB induced by overexpression of the NF-kappaB-inducing kinase (NIK), the IkappaB kinase alpha (IKKalpha), or the NF-kappaB subunit P65/RelA, suggesting it acts upstream of the latter proteins. Our results indicate that we have isolated a novel regulatory factor that is involved in signal transduction by distinct members of the TNF receptor family.

  6. TGF-β1 inhibits the production of IFN in response to CpG DNA via ubiquitination of TNF receptor-associated factor (TRAF) 6.

    Science.gov (United States)

    Naiki, Yoshikazu; Komatsu, Takayuki; Koide, Naoki; Dagvadorj, Jargalsaikhan; Yoshida, Tomoaki; Arditi, Moshe; Yokochi, Takashi

    2015-10-01

    The effect of TGF-β1 on CpG DNA-induced type I IFN production was examined by reconstituting a series of signaling molecules in TLR 3 signaling. TGF-β1 inhibited CpG DNA-induced IFN-α4 productivity in HeLa cells. Transfection of IFN regulatory factor (IRF)7 but not TNF receptor-associated factor (TRAF)6 and TRAF3 into cells triggered IFN-α4 productivity, and TGF-β1 inhibited IRF7-mediated type I IFN production in the presence of TRAF6. TGF-β1 induced ubiquitination of TRAF6, although CpG DNA did not induce it. Moreover, TGF-β1 accelerated the ubiquitination of TRAF6 in the presence of CpG DNA. TGF-β1 ubiquitinated TRAF6 at K63 but not K48. TGF-β1 also induced ubiquitination of IRF7. Further, TGF-β1 did not impair the interaction of IRF7 and TRAF6. CpG DNA induced the phosphorylation of IRF7 in the presence of TRAF6, whereas TGF-β1 inhibited the IRF7 phosphorylation. Blocking of TRAF6 ubiquitination abolished the inhibition of CpG DNA-induced type I IFN production by TGF-β. Taken together, TGF-β was suggested to inhibit CpG DNA-induced type I IFN production transcriptionally via ubiquitination of TRAF6.

  7. Up-regulation of fibroblast growth factor 19 and its receptor associates with progression from fatty liver to hepatocellular carcinoma

    Science.gov (United States)

    Doughtie, Anne; Cui, Guozhen; Li, Xuanyi; Pandit, Harshul; Yang, Yingbin; Li, Suping; Martin, Robert

    2016-01-01

    Background Human fibroblast growth factor 19 (FGF19), its receptor (FGFR4) and EpCAM play an important role in cell proliferation, differentiation, motility, and overexpression have been linked to hepatocellular carcinoma (HCC). The aim of this study was to evaluate the FGF19 signals responsible for the progression of HCC arising from fatty liver. Results FGF19 level was significantly increased in the HCC patients' serum compared to non-HCC controls. The IHC results demonstrated significant increases of protein expressions of FGF19, FGFR4 and EpCAM in specimens with fatty liver, NASH, cirrhosis, and HCC compared to healthy liver tissue. There was a significant positive correlation between the protein expressions (FGF19, FGFR4, and EpCAM) and histopathologic changes from FL to HCC. Furthermore, FGF19 was positively correlated with FGFR4 and with EpCAM. Materials and Methods FGF19 protein levels in serum and tissues were determined by ELISA assay. The FGFR4, and EpCAM expression and tissue distribution were further evaluated by immunohistochemical staining in tissue array samples. FGF19, FGFR4 and EpCAM expressions between the different histologic stages of fatty liver steatohepatitis-cirrhosis-HCC carcinogenesis sequence were compared to healthy hepatic tissue. Conclusions Overexpression of FGF19/FGFR4 significantly correlated with EpCAM as a marker of hepatic cancer stem cells within the fatty liver-steatosis-cirrhosis-HCC sequence. Impact This is the first study to elucidate FGF19/FGFR4 signaling in favor of HCC cells developing as indicated by increased EpCAM within the carcinogenesis sequence from fatty liver to hepatocellular carcinoma. Our study has the potential to yield novel and cost effective screening strategies for HCC patients. PMID:27447573

  8. Suppression of tumor necrosis factor receptor-associated protein 1 expression induces inhibition of cell proliferation and tumor growth in human esophageal cancer cells.

    Science.gov (United States)

    Tian, Xin; Ma, Ping; Sui, Cheng-Guang; Meng, Fan-Dong; Li, Yan; Fu, Li-Ye; Jiang, Tao; Wang, Yang; Jiang, You-Hong

    2014-06-01

    Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a molecular chaperone involved in multidrug resistance and antiapoptosis in some human tumors, but its regulatory mechanisms have not been revealed in esophageal squamous cell carcinoma (ESCC). In this study, 138 specimens of ESCC were analyzed. TRAP1 was overexpressed in ESCC, particularly in poorly differentiated tumors. To further explore the molecular regulatory mechanism, we constructed specific small interfering RNA-expressing vectors targeting Trap1, and knocked down Trap1 expression in the esophageal cancer cell lines ECA109 and EC9706. Knockdown of Trap1 induced increases in reactive oxygen species and mitochondrial depolarization, which have been proposed as critical regulators of apoptosis. The cell cycle was arrested in G2/M phase, and in vitro inhibition of cell proliferation was confirmed with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide and bromodeoxyuridine assays. Furthermore, re-expression of TRAP1 in Trap1 small interfering RNA-transfected ESCC cells restored cell proliferation and cell apoptosis. Bioluminescence of subcutaneously xenografted ESCC tumor cells demonstrated significant inhibition of in vivo tumor growth by Trap1 knockdown. This study shows that TRAP1 was overexpressed in most patients with ESCC, and caused an increase in antiapoptosis potency. TRAP1 may be regarded as a target in ESCC biotherapy.

  9. Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria*

    OpenAIRE

    Kim, Hyunjin; Yang, Jinsung; Kim, Min Ju; Choi, Sekyu; Chung, Ju-Ryung; Kim, Jong-Min; Yoo, Young Hyun; Chung, Jongkyeong; Koh, Hyongjong

    2015-01-01

    TRAP1 (tumor necrosis factor receptor-associated protein 1), a mitochondrial Hsp90 family chaperone, has been identified as a critical regulator of cell survival and bioenergetics in tumor cells. To discover novel signaling networks regulated by TRAP1, we generated Drosophila TRAP1 mutants. The mutants successfully developed into adults and produced fertile progeny, showing that TRAP1 is dispensable in development and reproduction. Surprisingly, mutation or knockdown of TRAP1 markedly enhance...

  10. HIV-1 Tat C-mediated regulation of tumor necrosis factor receptor-associated factor-3 by microRNA 32 in human microglia

    Directory of Open Access Journals (Sweden)

    Mishra Ritu

    2012-06-01

    Full Text Available Abstract Background HIV-1 Tat protein is known to be associated with neuroinflammation, a condition that develops in almost half of patients infected with HIV-1. HIV-1 Tat can alter glial neuroprotective functions, leading to neurotoxicity within the CNS. HIV-1 Tat is known to be secreted from productively infected cells and can affect neighboring uninfected cells by modulating cellular gene expression in a bystander fashion. Methods We were interested to study whether exogenous exposure to HIV-1 Tat-C protein perturbs the microRNA (miRNA expression profile of human microglial cells, leading to altered protein expression. We used protein expression and purification, miRNA overexpression, miRNA knockdown, transfection, site-directed mutagenesis, real-time PCR, luciferase assay and western blotting techniques to perform our study. Results HIV-1 Tat-C treatment of human microglial cells resulted in a dose-dependent increase in miR-32 expression. We found that tumor necrosis factor-receptor–associated factor 3 TRAF3 is a direct target for miR-32, and overexpression of miR-32 in CHME3 cells decreased TRAF3 both at the mRNA and the protein level. Recovery of TRAF3 protein expression after transfection of anti-miR-32 and the results of the luciferase reporter assay provided direct evidence of TRAF3 regulation by miR-32. We found that the regulation of interferon regulatory factor 3 (IRF3 and IRF7 is controlled by cellular levels of TRAF3 protein in microglial cells, as after overexpression of miR-32 and application of anti-miR-32, expression levels of IRF3 and IRF7 were inversely regulated by expression levels of TRAF3. Thus, our results suggest a novel miRNA mediated mechanism for regulation of TRAF3 in human microglial cells exposed to HIV-1 Tat C protein. These results may help to elucidate the detrimental neuroinflammatory consequences of HIV-1 Tat C protein in bystander fashion. Conclusion HIV-1 Tat protein can modulate TRAF3 expression through

  11. Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFα-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein.

    Science.gov (United States)

    Scudiero, Ivan; Zotti, Tiziana; Ferravante, Angela; Vessichelli, Mariangela; Reale, Carla; Masone, Maria C; Leonardi, Antonio; Vito, Pasquale; Stilo, Romania

    2012-02-17

    The pro-inflammatory cytokine tumor necrosis factor (TNF) α signals both cell survival and death. The biological outcome of TNFα treatment is determined by the balance between survival factors and Jun NH(2)-terminal kinase (JNK) signaling, which promotes cell death. Here, we show that TRAF7, the most recently identified member of the TNF receptor-associated factors (TRAFs) family of proteins, is essential for activation of JNK following TNFα stimulation. We also show that TRAF6 and TRAF7 promote unconventional polyubiquitination of the anti-apoptotic protein c-FLIP(L) and demonstrate that degradation of c-FLIP(L) also occurs through a lysosomal pathway. RNA interference-mediated depletion of TRAF7 correlates with increased c-FLIP(L) expression level, which, in turn, results in resistance to TNFα cytotoxicity. Collectively, our results indicate an important role for TRAF7 in the activation of JNK following TNFα stimulation and clearly point to an involvement of this protein in regulating the turnover of c-FLIP and, consequently, cell death.

  12. Tumor Necrosis Factor (TNF) Receptor-associated Factor 7 Is Required for TNFα-induced Jun NH2-terminal Kinase Activation and Promotes Cell Death by Regulating Polyubiquitination and Lysosomal Degradation of c-FLIP Protein*

    Science.gov (United States)

    Scudiero, Ivan; Zotti, Tiziana; Ferravante, Angela; Vessichelli, Mariangela; Reale, Carla; Masone, Maria C.; Leonardi, Antonio; Vito, Pasquale; Stilo, Romania

    2012-01-01

    The pro-inflammatory cytokine tumor necrosis factor (TNF) α signals both cell survival and death. The biological outcome of TNFα treatment is determined by the balance between survival factors and Jun NH2-terminal kinase (JNK) signaling, which promotes cell death. Here, we show that TRAF7, the most recently identified member of the TNF receptor-associated factors (TRAFs) family of proteins, is essential for activation of JNK following TNFα stimulation. We also show that TRAF6 and TRAF7 promote unconventional polyubiquitination of the anti-apoptotic protein c-FLIPL and demonstrate that degradation of c-FLIPL also occurs through a lysosomal pathway. RNA interference-mediated depletion of TRAF7 correlates with increased c-FLIPL expression level, which, in turn, results in resistance to TNFα cytotoxicity. Collectively, our results indicate an important role for TRAF7 in the activation of JNK following TNFα stimulation and clearly point to an involvement of this protein in regulating the turnover of c-FLIP and, consequently, cell death. PMID:22219201

  13. Anti-hepatitis B virus effect of matrine-type alkaloid and involvement of p38 mitogen-activated protein kinase and tumor necrosis factor receptor-associated factor 6.

    Science.gov (United States)

    Chen, Jia-Xin; Shen, Hong-Hui; Niu, Ming; Guo, Yu-Ming; Liu, Xiao-Qiong; Han, Yan-Zhong; Zhang, Ya-Ming; Zhao, Yan-Ling; Bai, Bing-Ke; Zhou, Wen-Jun; Xiao, Xiao-He

    2016-04-01

    The matrine-type alkaloid, oxymatrine inhibits hepatitis B virus (HBV) replication but very little is known about these effects in other matrine-type alkaloids, including sophoridine and sophocarpine. Therefore, we compared the in vitro anti-HBV effects of matrine, oxymatrine, sophocarpine, and sophoridine by treating an HBV-transfected cell line (HepG2.2.15) with 0.4-1.6mM of the compounds for 24 or 72h. The levels of the HBV surface antigen (HBsAg) and e antigen (HBeAg) in the culture medium, as well as the intracellular and extracellular HBV DNA levels, were determined. Metabolomic analysis and detection of the mRNA level of p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor receptor-associated factor (TRAF) 6, extracellular signal-regulated kinase (ERK) 1, NOD-like receptor family pyrin domain containing 10 (NLRP10), and caspase-1 were conducted in sophoridine-treated HepG2.2.15 cells. HepG2.2.15 cell exposure to 0.4-1.6mM sophocarpine or sophoridine for 24h reduced the HBsAg level of the medium more effectively than exposure to matrine and oxymatrine did, and reduced the HBeAg levels more effectively than these compounds did at 1.6mM. Sophoridine (0.4-1.6mM) reduced the cell medium HBV DNA levels more than the same concentrations of matrine, oxymatrine, or sophocarpine did. After 72h, 0.4 and 0.8mM sophoridine reduced HBsAg and intracellular HBV DNA levels more potently than matrine, oxymatrine, or sophocarpine did. Furthermore, sophoridine (0.8mM) potently reduced the cell medium HBeAg levels while the metabolomic analyses revealed that HepG2.2.15 cells exposed to 0.8mM sophoridine for 72h exhibited reduced cycloleucine and phytosphingosine levels. In addition, the mRNA expression analyses revealed that HepG2.2.15 cells exposed to 0.8mM sophoridine showed reduced levels of p38 MAPK, TRAF6, ERK1, NLRP10, and caspase-1. Sophoridine produced more potent anti-HBV effects than matrine, oxymatrine, and sophocarpine did. These effects may be related

  14. Genetic variation in the TNF receptor-associated factor 6 gene is associated with susceptibility to sepsis-induced acute lung injury

    Directory of Open Access Journals (Sweden)

    Song Zhenju

    2012-08-01

    Full Text Available Abstract Background Recent studies showed that overwhelming inflammatory response mediated by the toll-like receptor (TLR-related pathway was important in the development of acute lung injury (ALI. The aim of this study was to determine whether common genetic variation in four genes of the TLR signaling pathway were associated with sepsis-induced ALI susceptibility and risk of death in Chinese Han population. Methods Fourteen tag single nucleotide polymorphisms (tagSNPs in MyD88, IRAK1, IRAK4 and TRAF6 were genotyped in samples of sepsis-induced ALI (n = 272 and sepsis alone patients (n = 276, and tested for association in this case-control collection. Then, we investigated correlation between the associated SNP and the mRNA expression level of the corresponding gene. And we also investigated correlation between the associated SNP and tumor necrosis factor alpha (TNF-α as well as interleukin-6 (IL-6 concentrations in peripheral blood mononuclear cells (PBMCs exposed to lipopolysaccharides (LPS ex vivo. The mRNA expression level was determined using real-time quantitative Polymerase Chain Reaction (PCR assays, and concentrations of TNF-α and IL-6 were measured by enzyme-linked immunosorbent assay (ELISA. Results The association analysis revealed that rs4755453, an intronic SNP of TRAF6, was significantly associated with susceptibility to sepsis-induced ALI. The C allele frequency of rs4755453 in the sepsis alone group was significantly higher than that in the sepsis-induced ALI group (P = 0.00026, odds ratio (OR = 0.52, 95% confidence interval (CI 0.37–0.74. These associations remained significant after adjustment for covariates in multiple logistic regression analysis and for multiple comparisons. TRAF6 mRNA expression levels in PBMCs from homozygotes of the rs4755453G allele were significantly higher than that in heterozygotes and homozygotes of the rs4755453C allele at baseline (P = 0.012 and P = 0.003, respectively as

  15. Diagnostic and Predictive Levels of Calcium-binding Protein A8 and Tumor Necrosis Factor Receptor-associated Factor 6 in Sepsis-associated Encephalopathy: A Prospective Observational Study

    Institute of Scientific and Technical Information of China (English)

    Li-Na Zhang; Xiao-Hong Wang; Long Wu; Li Huang; Chun-Guang Zhao; Qian-Yi Peng; Yu-Hang Ai

    2016-01-01

    Background:Despite its high prevalence,morbidity,and mortality,sepsis-associated encephalopathy (SAE) is still poorly understood.The aim of this prospective and observational study was to investigate the clinical significance of calcium-binding protein A8 (S100A8) in serum and tumor necrosis factor receptor-associated factor 6 (TRAF6) in peripheral blood mononuclear cells (PBMCs) in diagnosing SAE and predicting its prognosis.Methods:Data of septic patients were collected within 24 h after Intensive Care Unit admission from July 2014 to March 2015.Healthy medical personnel served as the control group.SAE was defined as cerebral dysfunction in the presence of sepsis that fulfilled the exclusion criteria.The biochemical indicators,Glasgow Coma Scale,Acute Physiology and Chronic Health Evaluation score Ⅱ,TRAF6 in PBMC,serum S 100A8,S 100β,and neuron-specific enolase were evaluated in SAE patients afresh.TRAF6 and S 100A8 were also measured in the control group.Results:Of the 57 enrolled patients,29 were diagnosed with SAE.The S 100A8 and TRAF6 concentrations in SAE patients were both significantly higher than that in no-encephalopathy (NE) patients,and higher in NE than that in controls (3.74 ± 3.13 vs.1.08 ± 0.75 vs.0.37 ± 0.14 ng/ml,P < 0.01;3.18 ± 1.55 vs.1.02 ± 0.63 vs.0.47 ± 0.10,P < 0.01).S 100A8 levels of 1.93 ng/ml were diagnostic of SAE with 92.90% specificity and 69.00% sensitivity in the receiver operating characteristic (ROC) curve,and the area under the curve was 0.86 (95% confidence interval [CI]:0.76-0.95).TRAF6-relative levels of 1.44 were diagnostic of SAE with 85.70% specificity and 86.20% sensitivity,and the area under the curve was 0.94 (95% CI:0.88-0.99).In addition,S 100A8 levels of 2.41 ng/ml predicted 28-day mortality of SAE with 90.00% specificity and 73.70% sensitivity in the ROC curve,and the area under the curve was 0.88.TRAF6 relative levels of 2.94 predicted 28-day mortality of SAE with 80.00% specificity

  16. Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria*

    Science.gov (United States)

    Kim, Hyunjin; Yang, Jinsung; Kim, Min Ju; Choi, Sekyu; Chung, Ju-Ryung; Kim, Jong-Min; Yoo, Young Hyun; Chung, Jongkyeong; Koh, Hyongjong

    2016-01-01

    TRAP1 (tumor necrosis factor receptor-associated protein 1), a mitochondrial Hsp90 family chaperone, has been identified as a critical regulator of cell survival and bioenergetics in tumor cells. To discover novel signaling networks regulated by TRAP1, we generated Drosophila TRAP1 mutants. The mutants successfully developed into adults and produced fertile progeny, showing that TRAP1 is dispensable in development and reproduction. Surprisingly, mutation or knockdown of TRAP1 markedly enhanced Drosophila survival under oxidative stress. Moreover, TRAP1 mutation ameliorated mitochondrial dysfunction and dopaminergic (DA) neuron loss induced by deletion of a familial Parkinson disease gene PINK1 (Pten-induced kinase 1) in Drosophila. Gamitrinib-triphenylphosphonium, a mitochondria-targeted Hsp90 inhibitor that increases cell death in HeLa and MCF7 cells, consistently inhibited cell death induced by oxidative stress and mitochondrial dysfunction induced by PINK1 mutation in mouse embryonic fibroblast cells and DA cell models such as SH-SY5Y and SN4741 cells. Additionally, gamitrinib-triphenylphosphonium also suppressed the defective locomotive activity and DA neuron loss in Drosophila PINK1 null mutants. In further genetic analyses, we showed enhanced expression of Thor, a downstream target gene of transcription factor FOXO, in TRAP1 mutants. Furthermore, deletion of FOXO almost nullified the protective roles of TRAP1 mutation against oxidative stress and PINK1 mutation. These results strongly suggest that inhibition of the mitochondrial chaperone TRAP1 generates a retrograde cell protective signal from mitochondria to the nucleus in a FOXO-dependent manner. PMID:26631731

  17. Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria.

    Science.gov (United States)

    Kim, Hyunjin; Yang, Jinsung; Kim, Min Ju; Choi, Sekyu; Chung, Ju-Ryung; Kim, Jong-Min; Yoo, Young Hyun; Chung, Jongkyeong; Koh, Hyongjong

    2016-01-22

    TRAP1 (tumor necrosis factor receptor-associated protein 1), a mitochondrial Hsp90 family chaperone, has been identified as a critical regulator of cell survival and bioenergetics in tumor cells. To discover novel signaling networks regulated by TRAP1, we generated Drosophila TRAP1 mutants. The mutants successfully developed into adults and produced fertile progeny, showing that TRAP1 is dispensable in development and reproduction. Surprisingly, mutation or knockdown of TRAP1 markedly enhanced Drosophila survival under oxidative stress. Moreover, TRAP1 mutation ameliorated mitochondrial dysfunction and dopaminergic (DA) neuron loss induced by deletion of a familial Parkinson disease gene PINK1 (Pten-induced kinase 1) in Drosophila. Gamitrinib-triphenylphosphonium, a mitochondria-targeted Hsp90 inhibitor that increases cell death in HeLa and MCF7 cells, consistently inhibited cell death induced by oxidative stress and mitochondrial dysfunction induced by PINK1 mutation in mouse embryonic fibroblast cells and DA cell models such as SH-SY5Y and SN4741 cells. Additionally, gamitrinib-triphenylphosphonium also suppressed the defective locomotive activity and DA neuron loss in Drosophila PINK1 null mutants. In further genetic analyses, we showed enhanced expression of Thor, a downstream target gene of transcription factor FOXO, in TRAP1 mutants. Furthermore, deletion of FOXO almost nullified the protective roles of TRAP1 mutation against oxidative stress and PINK1 mutation. These results strongly suggest that inhibition of the mitochondrial chaperone TRAP1 generates a retrograde cell protective signal from mitochondria to the nucleus in a FOXO-dependent manner. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

  18. Multidimensional journal evaluation analyzing scientific periodicals beyond the impact factor

    CERN Document Server

    Haustein, Stefanie

    2012-01-01

    Scientific communication depends primarily on publishing in journals. The most important indicator to determine the influence of a journal is the Impact Factor. Since this factor only measures the average number of citations per article in a certain time window, it can be argued that it does not reflect the actual value of a periodical. This book defines five dimensions, which build a framework for a multidimensional method of journal evaluation. The author is winner of the Eugene Garfield Doctoral Dissertation Scholarship 2011.

  19. Suicide During Perinatal Period: Epidemiology, Risk Factors and Clinical Correlates

    Directory of Open Access Journals (Sweden)

    Laura Orsolini

    2016-08-01

    Full Text Available Perinatal period may pose a great challenge for the clinical management and treatment of psychiatric disorders in women. In fact, several mental illnesses can arise during pregnancy and/or following childbirth. Suicide and infanticide have been considered relatively rare events during the perinatal period. However, in some mental disorders (i.e. postpartum depression, bipolar disorder, postpartum psychosis, etc. have been reported a higher risk of suicidal ideation, suicide attempt or suicide. Therefore, a complete screening of mothers’ mental health should also take into account thoughts of suicide and thoughts about harming infants as well. Clinicians should carefully monitor and early identify related clinical manifestations, potential risk factors and alarm symptoms related to suicide. The present paper aims at providing a focused review about epidemiological data, risk and protective factors and an overview about the main clinical correlates associated with the suicidal behaviour during the pregnancy and postpartum period.

  20. Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction.

    Science.gov (United States)

    Park, Eui-Soon; Choi, Seunga; Shin, Bongjin; Yu, Jungeun; Yu, Jiyeon; Hwang, Jung-Me; Yun, Hyeongseok; Chung, Young-Ho; Choi, Jong-Soon; Choi, Yongwon; Rho, Jaerang

    2015-04-10

    The signaling pathway downstream of TNF receptor (TNFR) is involved in the induction of a wide range of cellular processes, including cell proliferation, activation, differentiation, and apoptosis. TNFR-associated factor 2 (TRAF2) is a key adaptor molecule in TNFR signaling complexes that promotes downstream signaling cascades, such as nuclear factor-κB (NF-κB) and mitogen-activated protein kinase activation. TRAF-interacting protein (TRIP) is a known cellular binding partner of TRAF2 and inhibits TNF-induced NF-κB activation. Recent findings that TRIP plays a multifunctional role in antiviral response, cell proliferation, apoptosis, and embryonic development have increased our interest in exploring how TRIP can affect the TNFR-signaling pathway on a molecular level. In our current study, we demonstrated that TRIP is negatively involved in the TNF-induced inflammatory response through the down-regulation of proinflammatory cytokine production. Here, we demonstrated that the TRAF2-TRIP interaction inhibits Lys(63)-linked TRAF2 ubiquitination by inhibiting TRAF2 E3 ubiquitin (Ub) ligase activity. The TRAF2-TRIP interaction inhibited the binding of sphingosine 1-phosphate, which is a cofactor of TRAF2 E3 Ub ligase, to the TRAF2 RING domain. Finally, we demonstrated that TRIP functions as a negative regulator of proinflammatory cytokine production by inhibiting TNF-induced NF-κB activation. These results indicate that TRIP is an important cellular regulator of the TNF-induced inflammatory response.

  1. Factors affecting the gestation period of pigs in Nigeria.

    Science.gov (United States)

    Leigh, A O

    1981-05-01

    Gestation periods taken from 432 records on purebred Large White, Duroc, Hampshire and their crossbred sows at Fashola Stock Farm in the Oyo State of Nigeria were analysed to determine the effects of some factors on the trait. For Large White, Duroc, Hampshire and the crossbred sows the mean gestation periods were 113.2, 115.1, 114.5 and 112.8 days respectively. Overall least squares mean was 11.2 days with a standard deviation of 9.06 days. Litter size at birth, year of birth and breed x season interaction had very highly significant effects of length of pregnancy. Breed differences were significant (P less than 0.05) whereas parity and season per se did not seem to influence this trait. Effects of boars accounted for some 11.8% of the trait was estimated as 0.47 r - 0.20 while the repeatability coefficient was 0.13. The data indicated a slight negative association between gestation period and litter size at birth.

  2. Obstructive Sleep Apnea Syndrome, Periodic Limb Movements and Related Factors

    Directory of Open Access Journals (Sweden)

    Osman Özgür Yalın

    2015-09-01

    Full Text Available OBJECTIVE: Obstructive sleep apnea syndrome (OSAS is characterized by nocturnal repetitive apnea episodes. Periodic limb movements (PLMs is nocturnal, stereotypic, repetitive movements of the lower extremities. The aim of this study was to investigate the presence of periodic limb movements in OSAS patients and correlation of PLM with OSAS severity. METHODS: One hundred and forty one OSAS suspected patients was enrolled into the study. All subjects’ blood pressure, heart rate measurements and neurologic examinations were made by the same neurologist. Sociodemographic characteristics were recorded. One night polysomnography (PSG was performed to all patients and results were analyzed. Apnea Hypopnea Index (AHI ≥ 5 subjects were accepted as OSAS, and PLM Index (PLMI ≥ 5 subjects were accepted as having PLM. RESULTS: One hundred and two patients were diagnosed as OSAS. The control group consisted of 39 patients who had normal polysomnographic findings. OSAS patients’ were older and body mass index (BMI were higher than the control group. Systolic blood pressure was higher in OSAS group. Alcohol use was determined as a risk factor for OSAS. PLM were more common in OSAS group than the control group (% 30,3 - % 10,2. PLM frequency was associated with the severity of OSAS. CONCLUSION: In OSAS patients presence of PLM was related with OSAS severity, higher systolic and diastolic blood pressure and REM sleep depletion. PLM in OSAS patients could be regarded as an indicator of disease severity and also could aware clinician for increased complication rates.

  3. A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).

    Science.gov (United States)

    Heydorn, Arne; Søndergaard, Birgitte P; Ersbøll, Bjarne; Holst, Birgitte; Nielsen, Finn Cilius; Haft, Carol Renfrew; Whistler, Jennifer; Schwartz, Thue W

    2004-12-24

    Adaptor and scaffolding proteins determine the cellular targeting, the spatial, and thereby the functional association of G protein-coupled seven-transmembrane receptors with co-receptors, transducers, and downstream effectors and the adaptors determine post-signaling events such as receptor sequestration through interactions, mainly with the C-terminal intracellular tails of the receptors. A library of tails from 59 representative members of the super family of seven-transmembrane receptors was probed as glutathione S-transferase fusion proteins for interactions with four different adaptor proteins previously proposed to be involved in post-endocytotic sorting of receptors. Of the two proteins suggested to target receptors for recycling to the cell membrane, which is the route believed to be taken by a majority of receptors, ERM (ezrin-radixin-moesin)-binding phosphoprotein 50 (EBP50) bound only a single receptor tail, i.e. the beta(2)-adrenergic receptor, whereas N-ethylmaleimide-sensitive factor bound 11 of the tail-fusion proteins. Of the two proteins proposed to target receptors for lysosomal degradation, sorting nexin 1 (SNX1) bound 10 and the C-terminal domain of G protein-coupled receptor-associated sorting protein bound 23 of the 59 tail proteins. Surface plasmon resonance analysis of the binding kinetics of selected hits from the glutathione S-transferase pull-down experiments, i.e. the tails of the virally encoded receptor US28 and the delta-opioid receptor, confirmed the expected nanomolar affinities for interaction with SNX1. Truncations of the NK(1) receptor revealed that an extended binding epitope is responsible for the interaction with both SNX1 and G protein-coupled receptor-associated sorting protein as well as with N-ethylmaleimide-sensitive factor. It is concluded that the tail library provides useful information on the general importance of certain adaptor proteins, for example, in this case, ruling out EBP50 as being a broad spectrum

  4. The role of tumor necrosis factor receptor-associated factor nuclear factor-κB-binding kinase 1 and stimulator of interferon genes mediated immune responses to DNA vaccines%肿瘤坏死因子受体相关因子联合核因子-κB激酶结合激酶1和干扰素刺激因子基因在介导DNA疫苗免疫中的作用

    Institute of Scientific and Technical Information of China (English)

    宿凌恺

    2012-01-01

    Tumor necrosis factor receptor-associated factor nuclear factor-KB-binding kinase 1 (TBK1) are already proved to play an important role in mediating immune responses to DNA vaccines, not only adaptive immune responses including cellular immunity and humoral immunity, but also innate immune responses. Recently, it is reported that stimulator of interferon genes (STING) is a significant element for the production of type I interferon to regulate innate immunity, which is mediated by TBK1. In this review, the role of TBK1 mediated immune responses to DNA vaccines and the role of STING gene mediated innate immune responses to TBK1 were introduced.%肿瘤坏死因子受体相关因子联合核因子-κB激酶结合激酶1(TBK1)基因不但在DNA疫苗诱导体液免疫和细胞免疫等特异性免疫时发挥着重要的作用,而且在诱导固有免疫方面也有其独特的作用.干扰素刺激因子基因(STING)是TBK1基因诱导I型干扰素产生从而在固有免疫反应时不可缺少的组分.本文就TBK1 和STING基因在介导DNA疫苗免疫中的作用作一综述.

  5. A new mutation causing autosomal dominant periodic fever syndrome in a Danish family

    DEFF Research Database (Denmark)

    Weyhreter, Heike; Schwartz, Marianne; Kristensen, Tim D

    2003-01-01

    We describe four members in a family of 8 individuals over 3 generations with the autosomal dominant inherited periodic fever syndrome tumor necrosis factor receptor-associated periodic syndrome (TRAPS). The patients had recurrent episodes of fever, abdominal pain, arthritis, and rash. We examined...

  6. Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers

    NARCIS (Netherlands)

    Federici, Silvia; Sormani, Maria Pia; Ozen, Seza; Lachmann, Helen J; Amaryan, Gayane; Woo, Patricia; Koné-Paut, Isabelle; Dewarrat, Natacha; Cantarini, Luca; Insalaco, Antonella; Uziel, Yosef; Rigante, Donato; Quartier, Pierre; Demirkaya, Erkan; Herlin, Troels; Meini, Antonella; Fabio, Giovanna; Kallinich, Tilmann; Martino, Silvana; Butbul, Aviel Yonatan; Olivieri, Alma; Kuemmerle-Deschner, Jasmin; Neven, Benedicte; Simon, Anna; Ozdogan, Huri; Touitou, Isabelle; Frenkel, Joost; Hofer, Michael; Martini, Alberto; Ruperto, Nicolino; Gattorno, Marco

    2015-01-01

    The objective of this work was to develop and validate a set of clinical criteria for the classification of patients affected by periodic fevers. Patients with inherited periodic fevers (familial Mediterranean fever (FMF); mevalonate kinase deficiency (MKD); tumour necrosis factor receptor-associate

  7. A new mutation causing autosomal dominant periodic fever syndrome in a Danish family

    DEFF Research Database (Denmark)

    Weyhreter, Heike; Schwartz, Marianne; Kristensen, Tim D;

    2003-01-01

    We describe four members in a family of 8 individuals over 3 generations with the autosomal dominant inherited periodic fever syndrome tumor necrosis factor receptor-associated periodic syndrome (TRAPS). The patients had recurrent episodes of fever, abdominal pain, arthritis, and rash. We examine...

  8. Factors affecting GPs workload in the period 1987-2001.

    NARCIS (Netherlands)

    Kolthof, E.D.; Berg, M.J. van den; Bakker, D.H. de

    2003-01-01

    Background: Like in other countries, Dutch general practitioners (GPs) perceive an increase in workload. Too much work pressure will affect the quality of care and threats the accessibility of health care provided by GPs. Factors on organisational-level, patient-level as well as on GP-level may

  9. Interaction of Tumor Necrosis Factor Receptor-associated Factors with the Latent Membrane Protein 1 Is Essential for Activation of NF-κB%EB病毒潜伏膜蛋白1通过结合TRAFs调控NF-κB

    Institute of Scientific and Technical Information of China (English)

    王承兴; 李晓艳; 顾焕华; 邓锡云; 曹亚

    2001-01-01

    为了探讨EB病毒潜伏膜蛋白1(LMP1)的致瘤机制,对鼻咽癌中LMP1激活重要 的核转录因子NF-κB机制进行了研究.首先,采用免疫共沉淀-蛋白质印迹在稳定表达LMP1 的鼻咽癌细胞系HNE2-LMP1中证实LMP1与TRAF1,2,3结合形成免疫共沉淀复合物,进一步以 野生型LMP1及其三种突变体的鼻咽癌细胞系LMP1(野生型,wt)、HNE2-LMP1 del187~3 51(CTAR1缺失型)、HNE2-LMP1(1~231)(CTAR2缺失型)、HNE2-LMP1(1~187)(羧基端胞浆 区缺失型)、HNE2-pSG5(空白载体型)为材料,结合NF-κB报道基因质粒(pGL2-NF-κB -luc)的荧光素酶活性表达分析NF-κB的活性,证实:较之母细胞, 野生型LMP1活化NF- κB达13.8倍, LMP1(1~187)几乎不活化NF-κB,LMP1(1~231)活化NF-κB达4.9倍, L MP1(del187~351)活化NF-κB达9.1倍;TRAF1过表达升高LMP1(wt)及LMP1(1~231)介导的 NF-κB活性,而对LMP1(del 187~351)活化NF-κB无影响;TRAF3过表达或TRAF3负显性 突变体抑制LMP1(wt)及LMP1(1~231)介导的NF-κB活性,而不影响LMP1(del 187~351)活 化NF-κB; TRAF2过表达升高LMP1(wt)、LMP1 (1~231)及LMP1(del 187~351)介导的NF-κB活性.这些结果表明:鼻咽癌中LMP1通过TRAF1、TRAF2或TRAF3调控NF-κB,TRAF1 和TRAF3主要通过CTAR1发挥作用,TRAF2的作用主要是通过CTAR1和CTAR2介导的.%The Epstein-Barr virus latent membrane protein 1 (LMP1) oncopro tein causes multiple cellular changes, including activation of the NF-κB trans cription factor. To elucidate its possible mechanism, the interaction between LM P1 and the tumor necrosis factor receptor associated factor (TRAF) molecules was detected by the immunoprecipitation-Western blotting assay. Results showed tha t LMP1 was co-precipitated with TRAF1,2,3 in the LMP1-HNE2 cell line. In the m eantime, κB reporter gene analysis revealed that over expression of TRAF1 or TR AF2 augmented LMP1-mediated NF-κB activation from LMP1, suprisingly, overexpr ession of

  10. [Early risk factors of eating disorders--do events of prenatal and perinatal periods bear significance?].

    Science.gov (United States)

    Raevuori, Anu; Niemelä, Solja; Keski-Rahkonen, Anna; Sourander, Andre

    2009-01-01

    Evidence of the relation of complications occurring in the pregnancy, delivery and neonatal periods to the risk of contracting a subsequent eating disorder has been obtained during recent years. Factors associated with parturition and neonatal period seem to predict both anorexia and bulimia, whereas disorders during pregnancy are more clearly associated with the descendant's anorexia. This difference may play an important role in the pathogenesis of the disorders.

  11. Frequent periodic leg movement during sleep is an unrecognized risk factor for progression of atrial fibrillation.

    Directory of Open Access Journals (Sweden)

    Mahek Mirza

    Full Text Available Sleep apnea has been recognized as a factor predisposing to atrial fibrillation recurrence and progression. The effect of other sleep-disturbing conditions on atrial fibrillation progression is not known. We sought to determine whether frequent periodic leg movement during sleep is a risk factor for progression of atrial fibrillation. In this retrospective study, patients with atrial fibrillation and a clinical suspicion of restless legs syndrome who were referred for polysomnography were divided into two groups based on severity of periodic leg movement during sleep: frequent (periodic movement index >35/h and infrequent (≤35/h. Progression of atrial fibrillation to persistent or permanent forms between the two groups was compared using Wilcoxon rank-sum test, chi-square tests and logistic regression analysis. Of 373 patients with atrial fibrillation (77% paroxysmal, 23% persistent, 108 (29% progressed to persistent or permanent atrial fibrillation during follow-up (median, 33 months; interquartile range, 16-50. Compared to patients with infrequent periodic leg movement during sleep (n=168, patients with frequent periodic leg movement during sleep (n=205 had a higher rate of atrial fibrillation progression (23% vs. 34%; p=0.01. Patients with frequent periodic leg movement during sleep were older and predominantly male; however, there were no significant differences at baseline in clinical factors that promote atrial fibrillation progression between both groups. On multivariate analysis, independent predictors of atrial fibrillation progression were persistent atrial fibrillation at baseline, female gender, hypertension and frequent periodic leg movement during sleep. In patients with frequent periodic leg movement during sleep, dopaminergic therapy for control of leg movements in patients with restless legs syndrome reduced risk of atrial fibrillation progression. Frequent leg movement during sleep in patients with restless legs syndrome is

  12. New determination of period and quality factor of Chandler wobble, considering geophysical excitations

    Science.gov (United States)

    Vondrák, J.; Ron, C.; Chapanov, Ya.

    2017-03-01

    Polar motion consists of both free (Chandler wobble, with approximately 14-month period) and forced components. The latter are caused by different excitations of geophysical origin. Very long-periodic (or secular) part is most probably due to post-glacial rebound, shorter periodic part (with dominant annual period) are caused mainly by motions of the atmosphere and oceans. Recently it was also proposed that impulse-like excitations due to geomagnetic jerks might be responsible for rapid changes of the amplitude and phase of Chandler wobble. In order to precisely determine the parameters of the free part, it is necessary to consider all these influences. We use the IERS combined solution C04 together with ERA atmospheric/oceanic excitations in the interval 1974.0-2014.0, and also additional excitations due to nine geomagnetic jerks, registered during this interval, to determine the period and quality factor of Chandler wobble, free from these geophysical effects. We obtained solutions for three different time intervals: 1974.0-1994.0, 1994.0-2014.0, and 1974.0-2014.0. The estimated values of Q-factor are much smaller if GMJ excitations are used in addition to atmospheric and oceanic ones, and they are determined with higher accuracy. Our preferred values, valid for the whole interval 1974.0-2014.0, are P = 432.86 ± 0.04 days and Q = 35.0 ± 0.3 .

  13. Empirical Research on the Factors of Chinese City Growth in the Transitional Period

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Based on the definition of the concept of city growth, the paper mainly discussed the factors which impact the growth of Chinese cities in the transitional period by selecting the proportion of city construction land area to the area of the city X1(%), green coverage ratio of the built up area X2(%), the ratio of personnel involved in the secondary industry X3(%), the GDP per capita X4(×104)and other 43 indicators, by relying on the relevant data from China Urban Statistical Yearbook(2008), applying SPSS statistical software and by applying the Factor Analysis and Regression Analysis. The results show that the factors which affect the city growth have four major groups, namely economic and institutional factors, location factors, environmental factors and social cultural services and functions. Among the factors which affect Chinese city growth, the general budgetary expenditures and the general budgetary revenues of local public finance are the most important factors. The general budgetary expenditures of local finance, the general budgetary revenues, the lands of urban construction and other 12 factors obtained by gradually excluding method can be used to present the coefficient of city growth.

  14. A library of 7TM receptor C-terminal tails - Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)

    DEFF Research Database (Denmark)

    Heydorn, A.; Sondergaard, B.P.; Ersbøll, Bjarne Kjær

    2004-01-01

    -coupled receptor-associated sorting protein bound 23 of the 59 tail proteins. Surface plasmon resonance analysis of the binding kinetics of selected hits from the glutathione S-transferase pull-down experiments, i.e. the tails of the virally encoded receptor US28 and the delta-opioid receptor, confirmed......Adaptor and scaffolding proteins determine the cellular targeting, the spatial, and thereby the functional association of G protein-coupled seven-transmembrane receptors with co-receptors, transducers, and downstream effectors and the adaptors determine post-signaling events such as receptor...... sequestration through interactions, mainly with the C-terminal intracellular tails of the receptors. A library of tails from 59 representative members of the super family of seven-transmembrane receptors was probed as glutathione S-transferase fusion proteins for interactions with four different adaptor...

  15. Relative-Price Changes and Demand Factors in the Period of Quantitative Easing in Japan

    OpenAIRE

    Hayo, Bernd; Ono, Hiroyuki

    2010-01-01

    Concentrating on the period of quantitative easing in Japan, this paper reexamines the correlation between the asymmetry of sectoral relative-price changes and the aggregate inflation rate. This correlation is widely interpreted as evidence that short-run inflation is determined by supply-side factors; however, we study whether, in addition to the inflation rate, monetary environment and aggregate demand explain this correlation. Using producer price index data, we show, first, that the posit...

  16. Periodically Collapsing Bubbles in Stock Prices Cointegrated with Broad Dividends and Macroeconomic Factors

    Directory of Open Access Journals (Sweden)

    Man Fu

    2011-12-01

    Full Text Available We study fluctuations in stock prices using a framework derived from the present value model augmented with a macroeconomic factor. The fundamental value is derived as the expected present discounted value of broad dividends that include, in addition to traditional cash dividends, other payouts to shareholders. A stochastic discount factor motivated by the consumption-based asset pricing model is utilized. A single macroeconomic factor, namely the output gap determines the non-fundamental component of stock prices. A resulting trivariate Vector Autoregression (TVAR model of stock prices, broad dividends, and the output gap shows evidence of cointegration in the DJIA and S&P 500 index data. Nonetheless, a sup augmented Dickey-Fuller test reveals existence of periodically collapsing bubbles in S&P 500 data during the late 1990s.

  17. Identifying erosive periods by using RUSLE factors in mountain fields of the Central Spanish Pyrenees

    Directory of Open Access Journals (Sweden)

    M. López-Vicente

    2008-03-01

    Full Text Available The Mediterranean environment is characterized by strong temporal variations in rainfall volume and intensity, soil moisture and vegetation cover along the year. These factors play a key role on soil erosion. The aim of this work is to identify different erosive periods in function of the temporal changes in rainfall and runoff characteristics (erosivity, maximum intensity and number of erosive events, soil properties (soil erodibility in relation to freeze-thaw processes and soil moisture content and current tillage practices in a set of agricultural fields in a mountainous area of the Central Pyrenees in NE Spain. To this purpose the rainfall and runoff erosivity (R, the soil erodibility (K and the cover-management (C factors of the empirical RUSLE soil loss model were used. The R, K and C factors were calculated at monthly scale. The first erosive period extends from July to October and presents the highest values of erosivity (87.8 MJ mm ha−1 h−1, maximum rainfall intensity (22.3 mm h−1 and monthly soil erosion (0.25 Mg ha−1 month−1 with the minimum values of duration of erosive storms, freeze-thaw cycles, soil moisture content and soil erodibility (0.007 Mg h MJ−1 mm−1. This period includes the harvesting and the plowing tillage practices. The second erosive period has a duration of two months, from May to June, and presents the lowest total and monthly soil losses (0.10 Mg ha−1 month−1 that correspond to the maximum protection of the soil by the crop-cover ($C$ factor = 0.05 due to the maximum stage of the growing season and intermediate values of rainfall and runoff erosivity, maximum rainfall intensity and soil erodibility. The third erosive period extends from November to April and has the minimum values of rainfall erosivity (17.5 MJ mm ha−1 h−1 and

  18. The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry

    NARCIS (Netherlands)

    Lachmann, H.J.; Papa, R.; Gerhold, K.; Obici, L.; Touitou, I.; Cantarini, L.; Frenkel, J.; Anton, J.; Kone-Paut, I.; Cattalini, M.; Bader-Meunier, B.; Insalaco, A.; Hentgen, V.; Merino, R.; Modesto, C.; Toplak, N.; Berendes, R.; Ozen, S.; Cimaz, R.; Jansson, A.; Brogan, P.T.; Hawkins, P.N.; Ruperto, N.; Martini, A.; Woo, P.; Gattorno, M.

    2014-01-01

    Objective To evaluate the genetic findings, demographic features and clinical presentation of tumour necrosis factor receptor-associated autoinflammatory syndrome (TRAPS) in patients from the Eurofever/EUROTRAPS international registry. Methods A web-based registry collected retrospective data on pat

  19. Low rank factorization of the Coulomb integrals for periodic coupled cluster theory

    CERN Document Server

    Hummel, Felix; Grüneis, Andreas

    2016-01-01

    We study the decomposition of the Coulomb integrals of periodic systems into a tensor contraction of six matrices of which only two are distinct. We find that the Coulomb integrals can be well approximated in this form already with small matrices compared to the number of real space grid points. The cost of computing the matrices scales as O(N^4) using a regularized form of the alternating least squares algorithm. The studied factorization of the Coulomb integrals can be exploited to reduce the scaling of the computational cost of expensive tensor contractions appearing in the amplitude equations of coupled cluster methods with respect to system size. We apply the developed methodologies to calculate the adsorption energy of a single water molecule on a hexagonal boron nitride monolayer in a plane wave basis set and periodic boundary conditions.

  20. Identifying erosive periods by using RUSLE factors in mountain fields of the Central Spanish Pyrenees

    Directory of Open Access Journals (Sweden)

    M. López-Vicente

    2007-07-01

    Full Text Available The Mediterranean environment is characterized by strong temporal variations in rainfall volume and intensity, soil moisture and vegetation cover along the year. These factors play a key role on soil erosion. The aim of this work is to identify different erosive periods in function of the temporal changes in rainfall and runoff characteristics (erosivity, maximum intensity and number of erosive events, soil properties (soil erodibility in relation to freeze-thaw processes and soil moisture content and current tillage practices in a set of agricultural fields in a mountainous area of the Central Pyrenees in NE Spain. To this purpose the rainfall and runoff erosivity (R, the soil erodibility (K and the cover-management (C factors of the empirical RUSLE soil loss model were used. The R, K and C factors were calculated at monthly scale. The first erosive period extends from July to October and presents the highest values of erosivity (87.8 MJ mm ha−1 h−1, maximum rainfall intensity (22.3 mm h−1 and monthly soil erosion (0.10 Mg ha−1 month−1 with the minimum values of duration of erosive storms, freeze-thaw cycles, soil moisture content and soil erodibility (0.007 Mg h MJ−1 mm−1. This period includes the harvesting and the plowing tillage practices. The second erosive period has a duration of two months, from May to June, and presents the lowest total and monthly soil losses (0.04 Mg ha−1 month−1 that correspond to the maximum protection of the soil by the crop-cover (C factor = 0.05 due to the maximum stage of the growing season and intermediate values of rainfall and runoff erosivity, maximum rainfall intensity and soil erodibility. The third erosive period extends from November to April and has the minimum values of rainfall erosivity (17.5 MJ mm ha−1 h−1 and maximum rainfall intensity (6.0 mm h−1

  1. General polynomial factorization-based design of sparse periodic linear arrays.

    Science.gov (United States)

    Mitra, Sanjit K; Mondal, Kalyan; Tchobanou, Mikhail K; Dolecek, Gordana Jovanovic

    2010-09-01

    We have developed several methods of designing sparse periodic arrays based upon the polynomial factorization method. In these methods, transmit and receive aperture polynomials are selected such that their product results in a polynomial representing the desired combined transmit/receive (T/R) effective aperture function. A desired combined T/R effective aperture is simply an aperture with an appropriate width exhibiting a spectrum that corresponds to the desired two-way radiation pattern. At least one of the two aperture functions that constitute the combined T/R effective aperture function will be a sparse polynomial. A measure of sparsity of the designed array is defined in terms of the element reduction factor. We show that elements of a linear array can be reduced with varying degrees of beam mainlobe width to sidelobe reduction properties.

  2. Factors influencing the presence of circulating differentiated thyroid cancer cells in the thyroidectomy perioperative period*

    Institute of Scientific and Technical Information of China (English)

    Wentao Wei; Qinjiang Liu; Wei Yao

    2015-01-01

    Objective The aim of the study was to detect circulating differentiated thyroid cancer (DTC) micrometas-tasis and to investigate the factors influencing their presence in the perioperative thyroidectomy period. Methods DTC micrometastases in the peripheral blood were detected with flow cytometry, and patient clinical and pathological factors were analyzed in 327 DTC patients.Results Circulating blood micrometastases were present in the peripheral circulation at a higher rate 1 week postoperatively than preoperatively and at 4 weeks postoperatively (P 0.05). At 4 weeks postoperatively, the presence of circulating micrometastasis was not associated with tumor size or lymph node stage (P > 0.05), but was associated with poorly differentiated tumors (P < 0.05). Conclusion The presence of circulating DTC micrometastases correlates to tumor size, lymph node stage, and operative manipulation. The differentiation degree of the tumors were associated with the persistent presence of micrometastasis in the circulating blood.

  3. DETERMINING THE EFFECTS OF THE FACTORS ON FDI IN GLOBAL CRISIS PERIOD

    Directory of Open Access Journals (Sweden)

    Selahattin GURIS

    2015-01-01

    Full Text Available The purpose of this study is to analyze factors affecting Foreign Direct Investment (FDI in countries with a high rate of FDI from 2005 to 2011, by examining the effects of the 2008 crisis. A Panel Tobit model is estimated in order to see the effects on the whole period, and classical Tobit models for each year are estimated separately for the purpose of examining the effects prior to, after and during the crisis, in detail. In the Tobit models, estimated separately for each year, the labor rate and inflation rate variables that are significant in panel Tobit models are not found significant for any of the examined years. As the balance of current accounts is found to be significant both prior to and after the crisis, it can be said that the effect of this variable on FDI is not affected by the crisis. Although there are studies examining factors affecting the FDI in the crisis period, to the best of our knowledge this is the only study using panel Tobit and classical Tobit models to that end.

  4. Phenomenological analysis of near threshold periodic modulations of the proton timelike form factor

    CERN Document Server

    Bianconi, A

    2015-01-01

    We have recently highlighted the presence of a periodically oscillating 10 \\% modulation in the BABAR data on the proton timelike form factors, in the reaction $e^++e^-$ $\\rightarrow$ $\\bar{p}+p$. Here we deepen our previous data analysis, and confirm that in the case of several standard parametrizations it is possible to write the form factor in the form $F_0$ $+$ $F_{osc}$, where $F_0$ is a parametrization expressing the long-range trend of the form factor (for $q^2$ ranging from the $\\bar{p}p$ threshold to 36 GeV$^2$), and $F_{osc}$ is a function of the form $\\exp(-Bp)\\cos(Cp)$, where $p$ is the relative momentum of the final $\\bar{p}p$ pair. Error bars allow for a clean identification of the main features of this modulation for $q^2$ $<$ 10 GeV$^2$. Assuming this oscillatory modulation to be an effect of final state interactions between the forming proton and the antiproton, we propose a phenomenological model based on a double-layer imaginary optical potential. This potential is flux-absorbing when th...

  5. The Analysis of the Risk Factors of Adverse Prognosis of Myocardial Infarction in the Acute Period

    Directory of Open Access Journals (Sweden)

    A. E. Zakharova

    2016-01-01

    Full Text Available The aim was to identify the risk factors contributed to adverse outcome of myocardial infarction (MI in the acute period of the disease at a prehospital stage.Materials and methods. The study included the call cards of specialized resuscitation and anesthesia units of the budgetary institution A. S. Puchkov «Station of emergency medical care», to patients with complicated MI. The study included two groups of patients. The first group comprized of patients with complicated MI which resulted in circulatory arrest (n=184, the second group (the group of comparison included patients with com plicated MI without the outcome in circulatory arrest (n=271. Statistical processing of the material: significance of differences between two binomial observations was evaluated by the Barnard's Exact Test.The results of the research. The presence of risk of MI complication as a stopping of blood circulation was confirmed in patients of the age group of 40—60 years (P=0.01. Patients with MI complicated by a circulatory arrest was characterized by a significantly greater intensity of pain syndrome (the pain intensity of 9—10 points was typ ical for 11,2% and 3% of patients of the group with circulatory arrest and the group of comparison, respectively; P< 0.001. The combination of clinical manifestations of alveolar pulmonary edema and arrhythmia occurred in 50% of patients with circulatory arrest, resulted in poor prognosis (the frequency of same parameters in a control group was 28,7%, P=0.018. Tachysystolic arrhythmia was the most common form of alteration at a circulatory arrest.Conclusions. The risk factors for MI adverse outcome in acute period included age from 40 to 60 years, pain of high intensity, presence of cardiogenic shock in combination with alveolar pulmonary edema and tachyarrhythmia.

  6. Emotional changes occurring in women in pregnancy, parturition and lying-in period according to factors exerting an effect on a woman during the peripartum period

    Directory of Open Access Journals (Sweden)

    Beata Pięta

    2014-09-01

    Full Text Available [b]Introduction[/b]. Pregnancy, parturition and childcare, which are important moments in a woman’s life, are connected with many emotional states of a future mother, a pregnant woman and a lying-in woman. The perinatal period is the time when the risk of psychological disorders in a pregnant woman may increase by even several times. [b]Objective.[/b] The objective of the study was recognition of the main emotional and psychological changes in pregnant women, those in labour and lying-in, according to the factors occurring during the peripartum period. [b]Material and method[/b]. The study was conducted in the form of a survey and covered a group of 108 mothers who were hospitalized in gynaecological-obstetric and obstetric wards in the Karol Marcinkowski Gynaecological-Obstetric University Hospital in Poznań. [b]Results[/b]. There are a number of factors which may exert a negative effect on the emotions of women in pregnancy, parturition, and during lying-in. The study showed that there is a close relationship between the occurrence of these factors and emotional states of the mothers after giving birth. [b]Conclusion[/b]. Special attention should be given to women in whom already during pregnancy factors arise which may have a negative impact on their mental state. Emotions during pregnancy, parturition and lying-in are often quite extreme, and achieve a high intensity, as well being very variable within a short period of time.

  7. The Effect of Carbon Dioxide Insufflation Applied at Different Pressures and Periods on Thrombotic Factors.

    Science.gov (United States)

    Sen, Mehmet Celal; Turkyilmaz, Zafer; Sonmez, Kaan; Karabulut, Ramazan; Kaya, Zuhre; Yenicesu, Idil; Gursel, Turkiz; Basaklar, Abdullah Can

    2016-03-01

    The aim of this experimantal study which is applied on rats, is to determine the differences on the clotting factors over the application of low and high intraabdominal pressure (IAP) values in different periods of time in carbon dioxide (CO2) pneumoperitoneum. Thirty rats were randomized into five groups (n = 6): a control group (Group K) and 1 h and 6 mm Hg IAP (Group A), 2 h and 6 mm Hg IAP (Group B), 1 h and 12 mm Hg IAP (Group C) and 2 h and 12 mm Hg IAP were created with CO2 pneumoperitoneum (Group D). At the end of the experiment, plasma samples taken from subjects and fibrinogen, FII (prothrombin), FV, FVII, FVIII, FIX, FX, FXI, FXII, von willebrand's factor (vWF), ristocetin cofactor, protein C, protein S, antithrombin III (AT III) levels are studied. There were statistically significant differences in the mean levels of FII, FV, FVII, FVIII, FIX, FX, FXI, FXII, and protein S between the groups. A hypercoagulable state occurred with the following: increase in the coagulation parameters compared to the control group; increase in FVII in the group only Group C; decrease in AT III in all groups compared to the control group; decrease in protein C in the group only XII Group D compared to control group; decrease in protein S in all groups except group D compared to control group. CO2 insufflation predisposes to thromboembolic events both by inducing coagulation factors and by suppressing the fibrinolytic system contrary to the controversies in the literature.

  8. Role of spatial inhomogenity in GPCR dimerisation predicted by receptor association-diffusion models

    Science.gov (United States)

    Deshpande, Sneha A.; Pawar, Aiswarya B.; Dighe, Anish; Athale, Chaitanya A.; Sengupta, Durba

    2017-06-01

    G protein-coupled receptor (GPCR) association is an emerging paradigm with far reaching implications in the regulation of signalling pathways and therapeutic interventions. Recent super resolution microscopy studies have revealed that receptor dimer steady state exhibits sub-second dynamics. In particular the GPCRs, muscarinic acetylcholine receptor M1 (M1MR) and formyl peptide receptor (FPR), have been demonstrated to exhibit a fast association/dissociation kinetics, independent of ligand binding. In this work, we have developed a spatial kinetic Monte Carlo model to investigate receptor homo-dimerisation at a single receptor resolution. Experimentally measured association/dissociation kinetic parameters and diffusion coefficients were used as inputs to the model. To test the effect of membrane spatial heterogeneity on the simulated steady state, simulations were compared to experimental statistics of dimerisation. In the simplest case the receptors are assumed to be diffusing in a spatially homogeneous environment, while spatial heterogeneity is modelled to result from crowding, membrane micro-domains and cytoskeletal compartmentalisation or ‘corrals’. We show that a simple association-diffusion model is sufficient to reproduce M1MR association statistics, but fails to reproduce FPR statistics despite comparable kinetic constants. A parameter sensitivity analysis is required to reproduce the association statistics of FPR. The model reveals the complex interplay between cytoskeletal components and their influence on receptor association kinetics within the features of the membrane landscape. These results constitute an important step towards understanding the factors modulating GPCR organisation.

  9. Factors associated with onset timing, symptoms, and severity of depression identified in the postpartum period.

    Science.gov (United States)

    Fisher, Sheehan D; Wisner, Katherine L; Clark, Crystal T; Sit, Dorothy K; Luther, James F; Wisniewski, Stephen

    2016-10-01

    Unipolar and bipolar depression identified in the postpartum period have a heterogeneous etiology. The objectives of this study are to examine the risk factors that distinguish the timing of onset for unipolar and bipolar depression and the associations between depression onset by diagnosis, and general and atypical depressive symptoms. Symptoms of depression were assessed at 4- to 6-weeks postpartum by the Structured Interview Guide for the Hamilton Depression Rating Scale-Atypical Depression Symptoms in an obstetrical sample of 727 women. Data were analyzed using ANOVA, Chi-square, and linear regression. Mothers with postpartum onset of depression were more likely to be older, Caucasian, educated, married/cohabitating, have one or no previous child, and have private insurance in contrast to mothers with pre-pregnancy and prenatal onset of depression. Mothers with bipolar depression were more likely to have a pre-pregnancy onset. Three general and two atypical depressive symptoms distinguished pre-pregnancy, during pregnancy, and postpartum depression onset, and the presence of agitation distinguished between unipolar and bipolar depression. The sample was urban, which may not be generalizable to other populations. The study was cross-sectional, which excludes potential late onset of depression (after 4-6 weeks) in the first postpartum year. A collective set of factors predicted the onset of depression identified in the postpartum for mothers distinguished by episodes of unipolar versus bipolar depression, which can inform clinical interventions. Future research on the onset of major depressive episodes could inform prophylactic and early psychiatric interventions. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. The joint return period analysis of natural disasters based on monitoring and statistical modeling of multidimensional hazard factors

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xueqin [State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875 (China); National Marine Environmental Monitoring Center, State Oceanic Administration, Dalian 116023 (China); School of Social Development and Public Policy, Beijing Normal University, Beijing 100875 (China); Li, Ning [State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875 (China); Yuan, Shuai, E-mail: syuan@nmemc.org.cn [National Marine Environmental Monitoring Center, State Oceanic Administration, Dalian 116023 (China); Xu, Ning; Shi, Wenqin; Chen, Weibin [National Marine Environmental Monitoring Center, State Oceanic Administration, Dalian 116023 (China)

    2015-12-15

    As a random event, a natural disaster has the complex occurrence mechanism. The comprehensive analysis of multiple hazard factors is important in disaster risk assessment. In order to improve the accuracy of risk analysis and forecasting, the formation mechanism of a disaster should be considered in the analysis and calculation of multi-factors. Based on the consideration of the importance and deficiencies of multivariate analysis of dust storm disasters, 91 severe dust storm disasters in Inner Mongolia from 1990 to 2013 were selected as study cases in the paper. Main hazard factors from 500-hPa atmospheric circulation system, near-surface meteorological system, and underlying surface conditions were selected to simulate and calculate the multidimensional joint return periods. After comparing the simulation results with actual dust storm events in 54 years, we found that the two-dimensional Frank Copula function showed the better fitting results at the lower tail of hazard factors and that three-dimensional Frank Copula function displayed the better fitting results at the middle and upper tails of hazard factors. However, for dust storm disasters with the short return period, three-dimensional joint return period simulation shows no obvious advantage. If the return period is longer than 10 years, it shows significant advantages in extreme value fitting. Therefore, we suggest the multivariate analysis method may be adopted in forecasting and risk analysis of serious disasters with the longer return period, such as earthquake and tsunami. Furthermore, the exploration of this method laid the foundation for the prediction and warning of other nature disasters. - Highlights: • A method to estimate the multidimensional joint return periods is presented. • 2D function allows better fitting results at the lower tail of hazard factors. • Three-dimensional simulation has obvious advantages in extreme value fitting. • Joint return periods are closer to the reality

  11. Comparison of Cardiovascular Risk Factors in Different Areas of Health Care Over a 20-Year Period

    Energy Technology Data Exchange (ETDEWEB)

    Jardim, Thiago Veiga, E-mail: thiagoveiga@cardiol.br; Sousa, Ana Luiza Lima [Liga de Hipertensão Arterial - Universidade Federal de Goiás, Goiânia, GO (Brazil); Povoa, Thais Rolim [Faculdade de Educação Física - Universidade Estadual de Goiás, Goiânia, GO (Brazil); Barroso, Weimar Sebba; Chinem, Brunela; Jardim, Paulo Cesar Veiga [Liga de Hipertensão Arterial - Universidade Federal de Goiás, Goiânia, GO (Brazil)

    2014-12-15

    Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Knowledge about cardiovascular risk factors (CVRFs) in young adults and their modification over time are measures that change the risks and prevent CVDs. To determine the presence of CVRFs and their changes in different health care professionals over a period of 20 years. All students of medicine, nursing, nutrition, odontology, and pharmacy departments of Federal University of Goiás who agreed to participate in this study were evaluated when they started their degree courses and 20 years afterward. Questionnaires on CVRFs [systemic arterial hypertension (SAH), diabetes mellitus, dyslipidemia, and family history of early CVD, smoking, alcohol consumption, and sedentarism] were administered. Cholesterol levels, blood sugar levels, blood pressure, weight, height, and body mass index were determined. The Kolmogorov-Smirnov test was used to evaluate distribution, the chi-square test was used to compare different courses and sexes, and the McNemar test was used for comparing CVRFs. The significance level was set at a p value of < 0.05. The first stage of the study included 281 individuals (91% of all the students), of which 62.9% were women; the mean age was 19.7 years. In the second stage, 215 subjects were reassessed (76% of the initial sample), of which 59.07% were women; the mean age was 39.8 years. The sample mostly consisted of medical students (with a predominance of men), followed by nursing, nutrition, and pharmacy students, with a predominance of women (p < 0.05). Excessive weight gain, SAH, and dyslipidemia were observed among physicians and dentists (p < 0.05). Excessive weight gain and SAH and a reduction in sedentarism (p < 0.05) were observed among pharmacists. Among nurses there was an increase in excessive weight and alcohol consumption (p < 0.05). Finally, nutritionists showed an increase in dyslipidemia (p < 0.05). In general, there was an unfavorable progression of CVRFs in the

  12. Factors influencing the chance of cows being pregnant 30 days after the herd voluntary waiting period.

    Science.gov (United States)

    Löf, E; Gustafsson, H; Emanuelson, U

    2014-01-01

    The objective of this study was to study factors affecting a reproductive performance indicator at the cow level adjusted for herd management strategy. Associations between the outcome variable, pregnant or not at the herd voluntary waiting period (VWP) plus 30d (pregnant at VWP+30), and the predictor variables were analyzed using a multivariable, generalized estimation equations model that adjusted for clustering of the data at the herd level. The statistical analysis was stratified on parity. In total, 132,721 cows were retained for analyses, of which 29,113 (22%) were pregnant at VWP+30d. Of the nonpregnant cows, 81,483 cows had records of artificial inseminations (AI) and 22,125 cows had no records of AI. The chance of pregnancy was higher for cows of the Swedish Red and for other/crossbreeds compared with Swedish Holstein, for cows from herds with high heat detection efficiency compared with cows from herds with medium and low heat detection efficiency, for cows from herds with long VWP (i.e., >51d) compared with cows from herds with short VWP (cows in freestalls compared with cows in tiestalls. The chance for pregnancy was lower for cows with severe problems at claw trimming compared with cows with no problems at trimming (only for second- and higher-parity cows), for cows that had a record of reproduction-related disease, for cows that had a record of any other disease compared with cows without record, for second- and higher-parity cows with records of dystocia compared with cows with no record of dystocia, for first-parity cows in the group with the highest milk yield compared with first-parity cows in the group with the lowest milk yield, for cows of third and higher parity in the group with the lowest milk yield compared with cows in higher yielding groups, for cows bred in summer compared with those bred in winter-spring (not significant for first-parity cows), and for cows with a twin birth had compared with cows with a single birth. We observed

  13. Comparison of Cardiovascular Risk Factors in Different Areas of Health Care Over a 20-Year Period

    Directory of Open Access Journals (Sweden)

    Thiago Veiga Jardim

    2014-12-01

    Full Text Available Background: Cardiovascular diseases (CVDs are the leading cause of death worldwide. Knowledge about cardiovascular risk factors (CVRFs in young adults and their modification over time are measures that change the risks and prevent CVDs. Objectives: To determine the presence of CVRFs and their changes in different health care professionals over a period of 20 years. Methods: All students of medicine, nursing, nutrition, odontology, and pharmacy departments of Federal University of Goiás who agreed to participate in this study were evaluated when they started their degree courses and 20 years afterward. Questionnaires on CVRFs [systemic arterial hypertension (SAH, diabetes mellitus, dyslipidemia, and family history of early CVD, smoking, alcohol consumption, and sedentarism] were administered. Cholesterol levels, blood sugar levels, blood pressure, weight, height, and body mass index were determined. The Kolmogorov-Smirnov test was used to evaluate distribution, the chi-square test was used to compare different courses and sexes, and the McNemar test was used for comparing CVRFs. The significance level was set at a p value of < 0.05. Results: The first stage of the study included 281 individuals (91% of all the students, of which 62.9% were women; the mean age was 19.7 years. In the second stage, 215 subjects were reassessed (76% of the initial sample, of which 59.07% were women; the mean age was 39.8 years. The sample mostly consisted of medical students (with a predominance of men, followed by nursing, nutrition, and pharmacy students, with a predominance of women (p < 0.05. Excessive weight gain, SAH, and dyslipidemia were observed among physicians and dentists (p < 0.05. Excessive weight gain and SAH and a reduction in sedentarism (p < 0.05 were observed among pharmacists. Among nurses there was an increase in excessive weight and alcohol consumption (p < 0.05. Finally, nutritionists showed an increase in dyslipidemia (p < 0.05. Conclusion

  14. EP4 Receptor-Associated Protein in Microglia Promotes Inflammation in the Brain.

    Science.gov (United States)

    Fujikawa, Risako; Higuchi, Sei; Nakatsuji, Masato; Yasui, Mika; Ikedo, Taichi; Nagata, Manabu; Yokode, Masayuki; Minami, Manabu

    2016-08-01

    Microglial cells play a key role in neuronal damage in neurodegenerative disorders. Overactivated microglia induce detrimental neurotoxic effects through the excess production of proinflammatory cytokines. However, the mechanisms of microglial activation are poorly understood. We focused on prostaglandin E2 type 4 receptor-associated protein (EPRAP), which suppresses macrophage activation. We demonstrated that EPRAP exists in microglia in the brain. Furthermore, EPRAP-deficient mice displayed less microglial accumulation, and intraperitoneal administration of lipopolysaccharide (LPS) led to reduced expression of tumor necrosis factor-α and monocyte chemoattractant protein-1 mRNA in the brains of EPRAP-deficient mice. Consistently, EPRAP-deficient microglia showed a marked decrease in the production of tumor necrosis factor-α and monocyte chemoattractant protein-1 induced by LPS treatment compared with wild-type controls. In addition, EPRAP deficiency decreased microglial activation and neuronal cell death induced by intraventricular injection of kainic acid. EPRAP deficiency impaired the LPS-induced phosphorylation of c-jun N-terminal kinase and p38 mitogen-activated protein kinase in microglia. The phosphorylation levels of mitogen-activated protein kinase kinase 4-which phosphorylates c-jun N-terminal kinase and p38 mitogen-activated protein kinase-were also decreased in EPRAP-deficient microglia after LPS stimulation. Although EPRAP in macrophages plays a role in the attenuation of inflammation, EPRAP promotes proinflammatory activation of microglia through mitogen-activated protein kinase kinase 4-mediated signaling and may be key to the deteriorating neuronal damage brought on by brain inflammation. Copyright © 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

  15. Factors Affecting Turnover Intention for New Graduate Nurses in Three Transition Periods for Job and Work Environment Satisfaction.

    Science.gov (United States)

    Yu, Mi; Kang, Kyung Ja

    2016-03-01

    The turnover rate of new graduate nurses in Korea is twice that of all Korean nurses; job/work environment satisfaction is a known risk factor. The authors examined these factors in new graduate nurses at various transition periods. A cross-sectional survey was conducted using stratified sampling from nine regions of Korea, and 443 new graduate nurses were enrolled. Job/work environment satisfaction and turnover intention were measured. Stepwise multiple regression analysis identified the factors affecting turnover intention. The factors differed through the transition periods. At 0 to 6 months, the factors were work schedule, desired hospital, orientation duration, becoming part of a team, professional development, and practical support; at 7 to 12 months, the factors were work schedule and desired hospital; and at 13 to 18 months, the factor was professional development, which accounted for 31%, 22.9%, and 12.6%, respectively, of the reasons for turnover intention. Reducing turnover intention requires consideration of the influential factors at each transition period. Copyright 2016, SLACK Incorporated.

  16. Factors Impacting Mortality in the Pre-Hospital Period After Road Traffic Accidents in Urban India.

    Science.gov (United States)

    Chandrasekharan, Ananthnarayan; Nanavati, Aditya J; Prabhakar, Sandhya; Prabhakar, Subramaniam

    2016-07-01

    India currently has the dubious distinction of experiencing the highest number of road traffic accidents in the world. We believe that this study on road traffic accidents may help to identify factors in the pre-hospital setting that may influence mortality rates. A prospective observational study was carried out in a metro area in India over a period of one year. The study included consecutive patients admitted to the trauma service after road traffic accidents. Demographic information, time and place of accident, and details regarding the vehicle and the events leading up to the hospital admission were recorded. Injury severity, management in the hospital, and final outcomes in terms of mortality were noted. The data were analyzed with SPSS software. A total of 773 patients were enrolled. Of these, there were 197 deaths and 576 survivors. The majority of patients were aged 15 - 40 years (67%) and were male (87.84%). More accidents occurred at night (58.2%) than during the day (41.8%). Mortality was not significantly associated with age, sex, or time of accident. City roads (38.9%) saw more accidents than highways (26.13%), but highway accidents were more likely to be fatal. Two-wheeler riders (37.65%) and pedestrians (35.75%) formed the majority of our study population. Mortality was significantly associated with crossing the road on foot (P = 0.004). Pillion riders on two-wheeler vehicles were more likely to experience poor outcomes (relative risk [RR] = 1.9, P = 0.001). Front-seat occupants in four-wheeler vehicles were at an increased risk of not surviving the accident (61.98%; RR=2.56, P = 0.01). Lack of safety gear, such as helmets, seat belts, and airbags, was significantly associated with mortality (P = 0.05). Delays in transfers of patients to the hospital and a lack of pre-hospital emergency services was significantly associated with increased mortality (P = 0.000). A lack of respect for the law, weak legislation and law enforcement, disregard for

  17. Use of Recombinant Factor VIIa in US Military Casualties for a Five-Year Period

    Science.gov (United States)

    2010-08-01

    Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled...particularly Factor VII level, in order that all of us could help learn the ideal plasma to red cell ratio by science rather than by some gestalt ? Dr. Slate

  18. Factor structure of the Japanese version of the Edinburgh Postnatal Depression Scale in the postpartum period.

    Directory of Open Access Journals (Sweden)

    Chika Kubota

    Full Text Available BACKGROUND: The Edinburgh Postnatal Depression Scale (EPDS is a widely used screening tool for postpartum depression (PPD. Although the reliability and validity of EPDS in Japanese has been confirmed and the prevalence of PPD is found to be about the same as Western countries, the factor structure of the Japanese version of EPDS has not been elucidated yet. METHODS: 690 Japanese mothers completed all items of the EPDS at 1 month postpartum. We divided them randomly into two sample sets. The first sample set (n = 345 was used for exploratory factor analysis, and the second sample set was used (n = 345 for confirmatory factor analysis. RESULTS: The result of exploratory factor analysis indicated a three-factor model consisting of anxiety, depression and anhedonia. The results of confirmatory factor analysis suggested that the anxiety and anhedonia factors existed for EPDS in a sample of Japanese women at 1 month postpartum. The depression factor varies by the models of acceptable fit. CONCLUSIONS: We examined EPDS scores. As a result, "anxiety" and "anhedonia" exist for EPDS among postpartum women in Japan as already reported in Western countries. Cross-cultural research is needed for future research.

  19. IL-1 Receptor-Associated Kinase Signaling and Its Role in Inflammation, Cancer Progression, and Therapy Resistance.

    Science.gov (United States)

    Jain, Ajay; Kaczanowska, Sabina; Davila, Eduardo

    2014-01-01

    Chronic inflammation has long been associated with the development of cancer. Among the various signaling pathways within cancer cells that can incite the expression of inflammatory molecules are those that activate IL-1 receptor-associated kinases (IRAK). The IRAK family is comprised of four family members, IRAK-1, IRAK-2, IRAK-3 (also known as IRAK-M), and IRAK-4, which play important roles in both positively and negatively regulating the expression of inflammatory molecules. The wide array of inflammatory molecules that are expressed in response to IRAK signaling within the tumor microenvironment regulate the production of factors which promote tumor growth, metastasis, immune suppression, and chemotherapy resistance. Based on published reports we propose that dysregulated activation of the IRAK signaling pathway in cancer cells contributes to disease progression by creating a highly inflammatory tumor environment. In this article, we present both theoretical arguments and reference experimental data in support of this hypothesis.

  20. IL-1 Receptor-associated kinase signaling and its role in inflammation, cancer progression and therapy resistance

    Directory of Open Access Journals (Sweden)

    Ajay eJain

    2014-11-01

    Full Text Available Chronic inflammation has long been associated with the development of cancer. Amongst the various signaling pathways within cancer cells that can incite the expression of inflammatory molecules are those that activate IL-1 receptor associated kinases (IRAK. The IRAK family comprises of four family members, IRAK-1, IRAK-2, IRAK-3 (also known as IRAK-M, and IRAK-4, which play important roles in both positively and negatively regulating the expression of inflammatory molecules. The wide array of inflammatory molecules that are expressed in response to IRAK signaling within the tumor microenvironment regulate the production of factors that promote tumor growth, metastasis, immune suppression and chemotherapy resistance. Based on published reports and compelling preliminary data, we propose that the dysregulated activation of the IRAK signaling pathway in cancer cells contributes to disease progression by creating a highly inflammatory tumor environment. In this article, we present both theoretical arguments and experimental data in support of this hypothesis.

  1. Comparative Study of Impacting Factors of Grain Production of Inner Mongolia Region in Different Periods

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    On the basis of grey correlation analysis,8 factors impacting grain production prominently as follows are selected to establish indices system:yield per unit(X1),grain planting area(X2),agricultural labor forces(X3),the total power of agricultural machinery(X4),using amount of fertilizer(X5),the damaged area of crops(X6),effective irrigation area(X7),and agricultural fixed assets investment(X8).According to the relevant data of Inner Mongolia Statistical Yearbook from 1988 to 2008,we use the method of grey correlation analysis to analyze the factors impacting grain production in Inner Mongolia,quantify the correlation degree of the total grain output and all factors,and finally conclude the impacting capacity of all factors on grain production in the light of correlation degree value.The results show that yield per unit still is the principal factor impacting the total output of grain in Inner Mongolia;the area of grain planting and the area of affected crops are the two most important factors responsible for the decrease of grain output;effective irrigation area the total power of agricultural machinery are the two primary factors impacting the increase of grain output;the using amount of fertilizer shows dwindling impact on grain production;agricultural fixed assets investment still hovers at the minuscule impact degree on grain production.

  2. The joint return period analysis of natural disasters based on monitoring and statistical modeling of multidimensional hazard factors.

    Science.gov (United States)

    Liu, Xueqin; Li, Ning; Yuan, Shuai; Xu, Ning; Shi, Wenqin; Chen, Weibin

    2015-12-15

    As a random event, a natural disaster has the complex occurrence mechanism. The comprehensive analysis of multiple hazard factors is important in disaster risk assessment. In order to improve the accuracy of risk analysis and forecasting, the formation mechanism of a disaster should be considered in the analysis and calculation of multi-factors. Based on the consideration of the importance and deficiencies of multivariate analysis of dust storm disasters, 91 severe dust storm disasters in Inner Mongolia from 1990 to 2013 were selected as study cases in the paper. Main hazard factors from 500-hPa atmospheric circulation system, near-surface meteorological system, and underlying surface conditions were selected to simulate and calculate the multidimensional joint return periods. After comparing the simulation results with actual dust storm events in 54years, we found that the two-dimensional Frank Copula function showed the better fitting results at the lower tail of hazard factors and that three-dimensional Frank Copula function displayed the better fitting results at the middle and upper tails of hazard factors. However, for dust storm disasters with the short return period, three-dimensional joint return period simulation shows no obvious advantage. If the return period is longer than 10years, it shows significant advantages in extreme value fitting. Therefore, we suggest the multivariate analysis method may be adopted in forecasting and risk analysis of serious disasters with the longer return period, such as earthquake and tsunami. Furthermore, the exploration of this method laid the foundation for the prediction and warning of other nature disasters.

  3. Fabricating centimeter-scale high quality factor two-dimensional periodic photonic crystal slabs.

    Science.gov (United States)

    Lee, Jeongwon; Zhen, Bo; Chua, Song-Liang; Shapira, Ofer; Soljačić, Marin

    2014-02-10

    We present a fabrication route for centimeter-scale two-dimensional defect-free photonic crystal slabs with quality factors bigger than 10,000 in the visible, together with a unique way to quantify their quality factors. We fabricate Si(3)N(4) photonic crystal slabs, and perform an angle-resolved reflection measurement. This measurement data is used to retrieve the quality factors of the slabs by fitting it to a model based on temporal coupled-mode theory. The macroscopic nature of the structure and the high quality factors of their resonances could open up new opportunities for realizing efficient macroscale optoelectronic devices such as sensors, lasers, and energy harvesting systems.

  4. Analysis of a log periodic nano-antenna for multi-resonant broadband field enhancement and the Purcell factor

    Science.gov (United States)

    Yang, Jie; Kong, Fanmin; Li, Kang; Sheng, Shiwei

    2015-05-01

    Broadband nano-antennas play a central role in many areas of science and technology. However, a more intuitive understanding for rational design of nano-antennas with broadband response is desirable. A log periodic nano-antenna was studied in the paper. The finite-difference time-domain method was used to explore the spectral characteristics of the log periodic nano-antenna by the excitation mode of reception and emission. The effects of geometry on field enhancement and the Purcell factor were systematically described and investigated. The field enhancement of the nano-antenna can be tuned by geometric parameters such as the outer radius, the tooth angle, and the ratio of the radial sizes of successive teeth, which provide control over both the spectral resonance position and the field enhancement peak amplitude. The Purcell factor mainly depends on the outer radius, the tooth angle, and the bow angle. In addition, multi-resonant field enhancement was analyzed in detail by conformal transformation. Furthermore, a careful comparison of the characteristics of a bowtie nano-antenna demonstrated that the log periodic nano-antenna has considerable potential for multi-resonant field enhancement and improvement of the Purcell factor. The results provide a promising prospect for designing and optimizing the log periodic nano-antenna in a broad range of wavelengths.

  5. BEDESTENS FROM OTTOMAN PERIOD: FACTORS OF INFLUENCE IMPLEMENTED IN CONTEMPORARY CITY CONCEPT

    Directory of Open Access Journals (Sweden)

    Petar Namičev

    2017-01-01

    Full Text Available Bedesten or covered marked, are usually located in the bazaar area of the Balkan city type. Bedesten was served as a place for the transactions of valuable goods, quality fabrics and the shops with luxury items in the past. The analysis of factors are presented at three characteristic preserved bedestens in Bitola, Skopje and Shtip, dating from XV-XVI century.Through presented factors were investigated the impacts of re-building and conservation interventions on the activity of objects in modern urban context, the role of the local community, which affects at the development of cultural tourism,at theambiental values of the environment, raising awareness, identifying and attitude of the population to the monuments.The identification of factors which affecting the modern treatment of historic buildings is important because of their adequate treatment adapted to modern needs, raising of awareness of population and development of cultural tourism.

  6. The use of antivascular endothelial growth factor agents in the perioperative period in diabetic vitrectomy

    Directory of Open Access Journals (Sweden)

    Nakhleh E Abu-Yaghi

    2012-01-01

    Full Text Available Pars plana vitrectomy is an established surgical method for the treatment of proliferative diabetic retinopathy and its complications. Anti-vascular endothelial growth factor agents suppress vascular proliferation and may be used as pharmacological adjuvants to reduce the incidence of postoperative hemorrhage in the vitreous cavity and to facilitate the surgical approach. We conducted an electronic search to identify prospective randomized controlled trials looking at the use of -perioperative vascular endothelial growth factor suppression in diabetic patients undergoing vitrectomy. We found six prospective randomized trials with only one being double-masked. We present a summary of the findings. Four studies suggest that the use of perioperative, anti-vascular endothelial growth factor agents facilitate vitrectomy surgery, but only one study supports their use to reduce the chances of early postoperative vitreous bleeding. Two studies did not find a significant benefit for their use before surgery to reduce the recurrence of vitreous hemorrhage in proliferative diabetic retinopathy. More randomized double blinded studies with a larger number of patients are needed to establish a clear recommendation regarding the use of these agents. Those studies should factor in the use of endo-tamponade with gas or silicone oil following vitrectomy.

  7. Is Age The Major Factor in Second Language Acquisition? -- An examination of the Critical Period Hypothesis

    Institute of Scientific and Technical Information of China (English)

    LiYing; LiuShufan

    2004-01-01

    Children, unlike adults, have an innate ability for learning language with great facility and minimal effort. This idea that early age is a major factor in native-proficient second language acquisition is a widely held and popular belief. Such views have been supported by many theories that were first proposed in the middle of the 20th century. This paper examines the

  8. Changes in Climatic Factors Influencing the Growth Period of Corn in Fengjie County

    Institute of Scientific and Technical Information of China (English)

    Xiaozhen; MAO; Xinli; MOU; Chen; MA; Jiang; HUANG; Lin; YUAN

    2014-01-01

    Under the background of global climate change,we analyze the change tendency of average temperature and amount of precipitation influencing the corn’s growth period. The results show that from March to August,the monthly temperatures show an upward trend,but the rise is different in different months,and the maximum temperature rise is in May. Precipitation in different months has different trends. Climate change brings about favorable conditions at high altitudes in Fengjie,reduces production due to the temperature drop after the beginning of autumn,and increases the pressure on the corn supply.

  9. Evaluation of abiotic factors on the activity period of crab-eating fox (Cerdocyon thous – Carnivora: Canidae

    Directory of Open Access Journals (Sweden)

    Fernando Rodrigo Tortato

    2009-12-01

    Full Text Available The activity period of the crab-eating fox (Cerdocyon thous was studied in the Itajaí valley, Santa Catarina state, southern Brazil, through camera traps during a 15-month survey. The existence of relationships between this behavior and abiotic factors was also investigated. We found that the crab-eating fox’s activity is basically nocturnal (54% and crepuscular (25%. It has been classified as cathemeral. However, there were no relationships among the abiotic factors estimated (rainfall, temperature and lunar phases.

  10. Critical evaluation of factors required to terminate the postclosure monitoring period at solid waste landfills

    DEFF Research Database (Denmark)

    Barlaz, M.A.; Rooker, A.P.; Kjeldsen, Peter

    2002-01-01

    requirements and regulatory activity that might be required to prepare regulators for the large number of requests to terminate postclosure monitoring expected over the next 20 years. An approach in which the frequency and extent of postclosure monitoring is reduced as warranted by site-specific data......Regulations governing the disposal of solid waste in landfills specify that they must be monitored for 30 years after closure unless this period is extended by the governing regulatory authority. Given the wide range of conditions under which refuse is buried, technical criteria, rather than...... water or groundwater. The acceptability of gaseous releases should be evaluated against criteria for odors, the potential for subsurface migration, and greenhouse gas and ozone precursor emissions. The approach presented here must be tested on a site-specific basis to identify additional data...

  11. Effect of the Nerve Growth Factor Mimetic GK-2 on Brain Structural and Functional State in the Early Postresuscitation Period

    Directory of Open Access Journals (Sweden)

    M. Sh. Avrushchenko

    2012-01-01

    Full Text Available Objective: to evaluate the efficacy of the nerve growth factor mimetic GK-2 used to improve the structural and functional state of the brain in the early postresuscitation period. Material and methods. Cardiac arrest was induced in mature male albino rats for 12 minutes, followed by resuscitation. The neurological state of the resuscitated animals was assessed by a scoring scale. On postresuscitation day 7, the density and composition of neuronal populations of Purkinje cells in the lateral cerebellar region and pyramidal neurons in the hippocampal CA1 sector were determined by a differential morphometric analysis. The results were statistically processed using the ANOVA method. Results. The use of GK-2 was found to accelerate neurological recovery in the resuscitated animals. On day 7 after 12-minute cardiac arrest, the resuscitated animals showed neuronal dystrophic changes and death in the neuronal populations highly susceptible to ischemia. It was shown that the systemic administration of the nerve growth factor mimetic GK-2 contributed to a reduction in the magnitude and depth of postresuscitation changes in the cerebellar Purkinje cells and prevented dystrophic changes in the pyramidal cells of the hippocampal CA1 sector. The findings suggest that GK-2 has a neuroprotective effect in the recovery period after total body ischemia. Conclusion. The results of this study indicate the efficiency of the systemic administration of the nerve growth factor mimetic GK-2 in improving the brain structural and functional state in the early postresuscitation period. This determines perspectives for the use of GK-2 to prevent and correct posthypoxic encephalopathies. Key words: the nerve growth factor mimetic GK-2, postresuscitation period, neuronal dystrophic changes and death, neurological status.

  12. Risk factors for mortality in patients with bloodstream infections during the pre-engraftment period after hematopoietic stem cell transplantation

    Science.gov (United States)

    Karpov, Igor; Milanovich, Natalia; Uss, Anatoly; Iskrov, Igor

    2016-01-01

    Background Bloodstream infections (BSI) remain a frequent complication during the pre-engraftment period after hematopoietic stem cell transplantation (HSCT), resulting in high mortality rates. This study evaluated risk factors for mortality in hematopoietic stem cell transplant recipients with BSI in the pre-engraftment period. Methods This prospective case control study was performed at the Center of Hematology and Bone Marrow Transplantation in Minsk, Republic of Belarus. Data relating to patient age and gender, date and type of transplantation, conditioning chemotherapy regimen, microorganisms isolated from blood, and antibacterial therapy were prospectively collected from all hematopoietic stem cell recipients with microbiologically proven cases of BSI in the pre-engraftment period. The primary outcome was all-cause 30-day mortality after onset of febrile neutropenia. Results A total of 135 adult patients with microbiologically proven BSI after HSCT were studied, with 65.2% of cases caused by gram-negative microorganisms and 21.5% by non-fermenting bacteria. Inadequate empiric antibacterial therapy and isolation of carbapenem-resistant non-fermenting gram-negative bacteria (Acinetobacter baumannii and Pseudomonas aeruginosa) were independently associated with increased all-cause 30-day mortality in these patients. Conclusion The risk factors for mortality in adult patients with BSI in the pre-engraftment period after HSCT were inadequacy of empirical antibacterial therapy and isolation of carbapenem-resistant A. baumannii or P. aeruginosa. PMID:27382554

  13. Incidence and risk factors for intimate partner violence during the postpartum period.

    Science.gov (United States)

    Silva, Elisabete Pereira; Valongueiro, Sandra; de Araújo, Thália Velho Barreto; Ludermir, Ana Bernarda

    2015-01-01

    OBJECTIVE To estimate the incidence and identify risk factors for intimate partner violence during postpartum. METHODS This prospective cohort study was conducted with women, aged between 18-49 years, enrolled in the Brazilian Family Health Strategy in Recife, Northeastern Brazil, between 2005 and 2006. Of the 1.057 women interviewed during pregnancy and postpartum, 539 women, who did not report violence before or during pregnancy, were evaluated. A theoretical-conceptual framework was built with three levels of factors hierarchically ordered: women's and partners' sociodemografic and behavioral characteristics, and relationship dynamics. Incidence and risk factors of intimate partner violence were estimated by Poisson Regression. RESULTS The incidence of violence during postpartum was 9.3% (95%CI 7.0;12.0). Isolated psychological violence was the most common (4.3%; 95%CI 2.8;6.4). The overlapping of psychological with physical violence occurred at 3.3% (95%CI 2.0;5.3) and with physical and/or sexual in almost 2.0% (95%CI 0.8;3.0) of cases. The risk of partner violence during postpartum was increased for women with a low level of education (RR = 2.6; 95%CI 1.3;5.4), without own income (RR = 1.7; 95%CI 1.0;2.9) and those who perpetrated physical violence against their partner without being assaulted first (RR = 2.0; 95%CI 1.2;3.4), had a very controlling partner (RR = 2.5; 95%CI 1.1;5.8), and had frequent fights with their partner (RR = 1.7; 95%CI 1.0;2.9). CONCLUSIONS The high incidence of intimate partner violence during postpartum and its association with aspects of the relationship's quality between the couple, demonstrated the need for public policies that promote conflict mediation and enable forms of empowerment for women to address the cycle of violence.

  14. Civil Society as one of the decisive factors of the Ukrainians’ consolidation in the Postcolonial period

    Directory of Open Access Journals (Sweden)

    I. M. Grabovska

    2017-04-01

    Full Text Available The actual problem of the modern Ukrainian society has been considered in the article. Civil society’s development is a major factor in the consolidation of the community. The consolidation of the Ukrainian postcolonial community is a crucial condition for its further existence as the state. Hybrid War of Russia against Ukraine is threatening its national integrity. The actuality of the issue is determined also by the tasks of the implementation of the stable democracy in Ukraine. The purpose of the article is to prove that civil society today is the most important factor, which is uniting the Ukrainian society. Today there are several concepts of the civil society. Many historical challenges have led to the creation of the civil society in these lands. For example, the establishment of the Magdeburg Law on ethnic Ukrainian lands united the cities’ public societies. Principles of life organisation by the Magdeburg Law were organic for Ukrainians. This was caused by a number of factors. In particular, it was the Ukrainian mentality. The Russian colonization of Ukraine destroyed the democratic principles of life in these lands, crashed civil solidarity and influenced the mentality of people. The phenomenon of the civil society is complex and multifaceted. Civil society is a space of the initiative of free citizens and NGOs, independent from the state and business. They willingly assume the responsibility for their maintenance of the social life outside the state and business. Civil society plays special role in postcolonial communities of the transition type. The Ukrainian society is such community now. The events of the Revolution of Dignity, and then the war in the eastern Ukraine have shown that the civil activity of the population by itself, the ability to act effectively and integrally created the conditions for preservation of the independent Ukrainian state. The consolidation of the Ukrainians in the most dangerous times of

  15. Data from "Cohort differences in big five personality factors over a period of 25 years"

    OpenAIRE

    Smits, Iris A. M.; Conor V Dolan; Harrie C. Vorst; Jelte M Wicherts; Timmerman, M.E.

    2013-01-01

    This data set comprises of scores of 8,954 psychology freshmen from the University of Amsterdam (1982-2007) on the ‘Vijf PersoonlijkheidsFactoren Test’ or 5PFT developed by Elshout and Akkerman, which is an instrument to measure the Big Five personality factors Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness to Experience. Data were collected during the yearly freshmen-testing program from 1982-2007 and include scores at the level of 70 items that can be used in stud...

  16. Novel Role and Regulation of the Interleukin-1 Receptor Associated Kinase (IRAK) Family Proteins

    Institute of Scientific and Technical Information of China (English)

    Yingsu Huang; Anna Misior; Liwu Li

    2005-01-01

    The interleukin-1 receptor associated kinases (IRAKs) sit at the bottle neck for the Toll-like-receptor (TLR) mediated signal transduction process controlling host innate immune response. However, the exact role and regulation of IRAKs are still in the early stage and not fully understood. This review intends to summarize the recent advancement in this important topic and points out areas that need further intensive investigation.

  17. Novel Role and Regulation of the Interleukin-1 Receptor Associated Kinase (IRAK) Family Proteins

    Institute of Scientific and Technical Information of China (English)

    YingsuHuang; AnnaMisior

    2005-01-01

    The interleukin-1 receptor associated kinases (IRAKs) sit at the bottle neck for the Toll-like-receptor (TLR) mediated signal transduction process controlling host innate immune response. However, the exact role and regulation of IRAKs are still in the early stage and not fully understood. This review intends to summarize the recent advancement in this important topic and points out areas that need further intensive investigation. Cellular & Molecular Immunology. 2005;2(1):36-39.

  18. [Anaemia in pregnancy and in the immediate postpartum period. Prevalence and risk factors in pregnancy and childbirth].

    Science.gov (United States)

    Urquizu I Brichs, Xavier; Rodriguez Carballeira, Mónica; García Fernández, Antonio; Perez Picañol, Emilio

    2016-05-20

    The objective of the study was to assess the prevalence of anaemia in the immediate postpartum period (48-72hours), determine the risk factors and the value of haemoglobin before birth to reduce postpartum anaemia. A prospective, observational and longitudinal study that included 1,426 women who delivered consecutively and agreed to participate in the study. Different variables, analytical, epidemiological, foetal and maternal symptoms were studied. The prevalence of anaemia in the postpartum period was 49.7%. The most important risk factors were antepartum anaemia and type of delivery. The types of delivery most influencing postpartum anaemia were, forceps (82.3%), the ventouse 67%, cesarean section (58,2%) and vaginal delivery (37.2%). In the multivariate study was found as the most important independent risk factors, the haemoglobin in the delivery day (OR 6.16, CI: 3.73 to 10.15) and instrumental delivery (OR: 4.61, CI: 3.44 to 6, 19). Other independent risk factors were haemoglobin in the third trimester, episiotomy and perineal tears, ethnicity, birth weight, parity and intra/postpartum complications. Anaemia in the immediate postpartum is a prevalent problem. The factors most associated postpartum anaemia were antepartum anaemia and instrumental delivery. If patients arrive at the day of delivery with haemoglobins≥12,6g/dl and were restricted to necessary instrumented deliveries and cesarean sections, episiotomies and we could avoid perineal tears we can decrease anaemia in the immediate postpartum period very significantly. Copyright © 2016 Elsevier España, S.L.U. All rights reserved.

  19. Differentiating PFAPA syndrome from monogenic periodic fevers.

    Science.gov (United States)

    Gattorno, Marco; Caorsi, Roberta; Meini, Antonella; Cattalini, Marco; Federici, Silvia; Zulian, Francesco; Cortis, Elisabetta; Calcagno, Giuseppina; Tommasini, Alberto; Consolini, Rita; Simonini, Gabriele; Pelagatti, Maria Antonietta; Baldi, Maurizia; Ceccherini, Isabella; Plebani, Alessandro; Frenkel, Joost; Sormani, Maria Pia; Martini, Alberto

    2009-10-01

    To analyze whether there were clinical differences between genetically positive and negative patients fulfilling periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome criteria and to test the accuracy of the Gaslini diagnostic score for identifying patients with PFAPA syndrome with higher probabilities of carrying relevant mutations in genes associated with periodic fevers. Complete clinical and genetic information was available for 393 children with periodic fever; 82 had positive genetic test results, 75 had incomplete genetic test results, and 236 had negative results for MVK, TNFRSF1A, and MEFV mutations. Current diagnostic criteria for PFAPA syndrome were applied. Of 393 children, 210 satisfied PFAPA syndrome criteria; 43 carried diagnostic mutations (mevalonate kinase deficiency: n = 33; tumor necrosis factor receptor-associated periodic syndrome: n = 3; familial Mediterranean fever: n = 7), 37 displayed low-penetrance mutations or incomplete genotypes, and 130 demonstrated negative genetic testing results. Genetically positive patients had higher frequencies of abdominal pain and diarrhea (P < .001), vomiting (P = .006), and cutaneous rash and arthralgia (P = .01). Genetically negative patients had a higher frequency of exudative pharyngitis (P = .010). Genetically undetermined patients showed the same pattern of symptom frequency as genetically negative patients. The Gaslini diagnostic score was able to identify 91% of genetically positive patients correctly, with a global accuracy of 66%. The Gaslini diagnostic score represents a useful tool to identify patients meeting PFAPA syndrome criteria and at low risk of carrying relevant mutations in genes associated with periodic fevers.

  20. Incidence and risk factors for intimate partner violence during the postpartum period

    Directory of Open Access Journals (Sweden)

    Elisabete Pereira Silva

    2015-01-01

    Full Text Available OBJECTIVE To estimate the incidence and identify risk factors for intimate partner violence during postpartum.METHODS This prospective cohort study was conducted with women, aged between 18-49 years, enrolled in the Brazilian Family Health Strategy in Recife, Northeastern Brazil, between 2005 and 2006. Of the 1.057 women interviewed during pregnancy and postpartum, 539 women, who did not report violence before or during pregnancy, were evaluated. A theoretical-conceptual framework was built with three levels of factors hierarchically ordered: women’s and partners’ sociodemografic and behavioral characteristics, and relationship dynamics. Incidence and risk factors of intimate partner violence were estimated by Poisson Regression.RESULTS The incidence of violence during postpartum was 9.3% (95%CI 7.0;12.0. Isolated psychological violence was the most common (4.3%; 95%CI 2.8;6.4. The overlapping of psychological with physical violence occurred at 3.3% (95%CI 2.0;5.3 and with physical and/or sexual in almost 2.0% (95%CI 0.8;3.0 of cases. The risk of partner violence during postpartum was increased for women with a low level of education (RR = 2.6; 95%CI 1.3;5.4, without own income (RR = 1.7; 95%CI 1.0;2.9 and those who perpetrated physical violence against their partner without being assaulted first (RR = 2.0; 95%CI 1.2;3.4, had a very controlling partner (RR = 2.5; 95%CI 1.1;5.8, and had frequent fights with their partner (RR = 1.7; 95%CI 1.0;2.9.CONCLUSIONS The high incidence of intimate partner violence during postpartum and its association with aspects of the relationship’s quality between the couple, demonstrated the need for public policies that promote conflict mediation and enable forms of empowerment for women to address the cycle of violence.

  1. [An analysis of the risk factors for the severity of paralysis in patients with hypokalemic periodic paralysis].

    Science.gov (United States)

    Dou, Ru-xiang; Zou, Liang-yu; Li, Zhuo-xing

    2010-03-01

    To analyze the independent factors for the severity of paralysis in the patients with hypokalemic periodic paralysis (HOPP). Eighty patients admitted with HOPP were reviewed. Using univariate analysis and multivariate analysis, the independent factors for the severity of paralysis were revealed. A total of 76 cases were male and 4 female with a mean age of (26.3 +/- 4.5) years. Univariate analysis showed that patients with low serum magnesium level, low serum potassium level, high serum creatine kinase level, changes of electrocardiogram, chest distress and palpitation, nausea and vomiting as well as muscular soreness had more severe paralysis, while multivariate analysis revealed that serum magnesium 200 U/L (OR 1.1, 95%CI 1.0 - 1.1, P paralysis. Low serum magnesium level, low serum potassium level and high serum creatine kinase level are the independent risk factors for more severe paralysis in patients with HOPP.

  2. Factors associated with intern noncompliance with the 2003 Accreditation Council for Graduate Medical Education's 30-hour duty period requirement.

    Science.gov (United States)

    Maloney, Christopher G; Antommaria, Armand H Matheny; Bale, James F; Ying, Jian; Greene, Tom; Srivastava, Rajendu

    2012-07-13

    In 2003 the Accreditation Council for Graduate Medical Education mandated work hour restrictions. Violations can results in a residency program being cited or placed on probation. Recurrent violations could results in loss of accreditation. We wanted to determine specific intern and workload factors associated with violation of a specific mandate, the 30-hour duty period requirement. Retrospective review of interns' performance against the 30-hour duty period requirement during inpatient ward rotations at a pediatric residency program between June 24, 2008 and June 23, 2009. The analytical plan included both univariate and multivariable logistic regression analyses. Twenty of the 26 (77%) interns had 80 self-reported episodes of continuous work hours greater than 30 hours. In multivariable analysis, noncompliance was inversely associated with the number of prior inpatient rotations (odds ratio: 0.49, 95% confidence interval (0.38, 0.64) per rotation) but directly associated with the total number of patients (odds ratio: 1.30 (1.10, 1.53) per additional patient). The number of admissions on-call, number of admissions after midnight and number of discharges post-call were not significantly associated with noncompliance. The level of noncompliance also varied significantly between interns after accounting for intern experience and workload factors. Subject to limitations in statistical power, we were unable to identify specific intern characteristics, such as demographic variables or examination scores, which account for the variation in noncompliance between interns. Both intern and workload factors were associated with pediatric intern noncompliance with the 30-hour duty period requirement during inpatient ward rotations. Residency programs must develop information systems to understand the individual and experience factors associated with noncompliance and implement appropriate interventions to ensure compliance with the duty hour regulations.

  3. Expression of germ cell nuclear factor in mouse germ cells and sperm during postnatal period

    Institute of Scientific and Technical Information of China (English)

    ChenXu; Zong-YaoZhou; Qiang-SuGuo; Yi-FeiWang

    2004-01-01

    Aim: To assess the spatial and temporal expression of germ cell nuclear factor (GCNF) in male mouse germ cells during postnatal development and in sperm before and after capacitation. Methods: The indirect immunofluorescence method with anti-GCNF antiserum was used to investigate the GCNF expression in mice at day 8, 10,14, 17, 20, 28, 35, 70, and 420 after birth and in sperm before and after capacitation. Results: With the proceeding of spermatogenesis, GCNF was first detected in the nuclei of spermatogonia and a few early stage primary spermatocytes at day 8, which was increased gradually at day 10 to 14 inclusive. From day 17 to day 20, the GCNF was concentrated in round spermatids, while both spermatogonia and early stage primary spermatocytes became GCNF negative. From day 28 until day 420, strong GCNF expression was shown in round spermatids and pachytene spermatocytes, while spermatogonia, early primary spermatocytes and elongating spermatids were all GCNF negative.In addition, it was also found that GCNF was localized on the acrosomal cap region of spermatozoa and there was a big change in GCNF expression during capacitation, from 98 % GCNF positive before capacitation to about 20 % positive following capacitation. The localization of GCNF in caput and cauda spermatozoa was similar. Conclusion:GCNF may play important roles in spermatogenesis, capacitation and fertilization. (Asian J Androl 2004 Sep; 6: 217-222)

  4. Study of anti-vascular endothelial growth factor medicine for proliferative diabetic retinopathy at perioperative period

    Directory of Open Access Journals (Sweden)

    Mei Sun

    2015-10-01

    Full Text Available AIM:To compare clinical effects of intravitreal injection of anti-vascular endothelial growth factor(VEGFmedicine for proliferative diabetic retinopathy(PDR. METHODS: Eighty-four patients with PDR(84 eyesin our hospital in January 2010 to January 2015 were selected, and were randomly divided into three groups(A, B, C, 28 eyes of 28 cases . The patients in group A underwent vitrectomy, those in group B received intravitreal injection of ranibizumab before vitrectomy; and those in group C got intravitreal injection of conbercept before vitrectomy. Operative time, complications, and postoperative best-corrected visual acuity at 6mo of the three groups were compared.RESULTS: After treatment, the incidence of intraoperative and postoperative complications and the operation time of group B and group C were lower than those of group A. Compared best corrected visual acuity at preoperative and postoperative 6mo, and among three groups, there were no statistically significance difference(PP>0.05.CONCLUSION: Intravitreal injection of ranibizumab and conbercept before vitrectomy can decrease the operation time and intraoperative bleeding, reduce the incidence of intraoperative and postoperative complications and improve BCVA of patients in the treatment of PDR.

  5. Proteins of the Hageman Factor System in an Inflammatory Reaction in the Acute Period of Severe Brain Injury

    Directory of Open Access Journals (Sweden)

    T. I. Borshchikova

    2010-01-01

    Full Text Available Objective: to study the time course of changes and an association of contact factors and their inhibitors with the global values of hemocoagulation, fibrinolysis, and inflammatory reactants in acute severe brain injury (SBI in order to deepen notions of Hageman factor system functioning. Subjects and methods. One hundred and thirteen patients with SBI were examined on 1 to 21 days of injury. The level of unconsciousness averaged a Glasgow coma score of 6.8±0.25. A control group included 23 healthy individuals. The investigators determined the activity of contact factors (prekallikrein, high-molecular-weight kininogen, factors XII, XI and their inhibitors (total activity of the protein C system, the activity and quantity of antithrombin III, C1 esterase inhibitor, a^antitrypsin, fl^-antiplasmin, fl^-macroglobulin, hemostatic parameters (blood fibrinolytic activity by an euglobulin test; factor XII-kallikrein-dependent fibrinolysis, treptokinase induced fibrinolysis by calculating the plasminogen reserve index, activated partial thromboplastin time, fibrinogen, D-dimer, and soluble fibrin monomer complexes, and inflammatory reactants (C-reactive protein, IL10, IL2, IL4, IL5, IL6, IL8, IL10, IL12p70, TNF-a, and IFN-y. Results. The acute period of SBI was marked by significant deficiency and imbalance of contact factors and their physiological inhibitors. In SBI, prekallikrein rather than factor XII plays a central role in the function of the contact factor system due to inflammatory inhibition of Hageman factor synthesis, which disturbs its key role in the reactions of contact activation of homeostatic proteolytic systems. Out of the considered systems, the activation of which is associated with contact factors, the function of the internal mechanism of fibrinolysis is largely changed; at the same time the internal hemocoagulation activation pathway remains virtually intact. When an inflammatory reaction develops after SBI, normal Hageman factor

  6. Human Factors Evaluation of Man-Machine Interface for Periodic Safety Review of Yonggwang Unit no. 1, 2

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Hee; Lee, Jung Woon; Park, Jae Chang (and others)

    2006-01-15

    This report describes the research results of human factors assessment on the MMI(Man Machine Interface) equipment as part of Periodic Safety Review(PSR) of Yonggwang Unit no. 1, 2. As MMI is a key factor among human factors to be reviewed in PSR, we reviewed the MMI components of nuclear power plants in aspect of human factors engineering. The availability, suitability, and effectiveness of the MMI devices were chosen to be reviewed. The MMI devices were investigated through the review of design documents related to the MMI, survey of control panels, evaluation of experts, and experimental assessment. Checklists were used to perform this assessment and record the review results. The items mentioned by the expert comments to review in detail in relation with task procedures were tested by experiments with operators' participation. For some questionable issues arisen during this MMI review, operator workload and possibility of errors in operator actions were analysed. The reviewed MMI devices contain MCR(Main Control Room), SPDS(Safety Parameter Display System), RSP(Remote Shutdown Panel), and the selected LCBs(Local Control Boards) importantly related to safety. As results of the assessments, any significant problem challenging the safety was not found on human factors in the MMI devices. However, several small items to be changed and improved in suitability of MMI devices were discovered. An action plan is recommended to accommodate the suggestions and review comments. It will enhance the plant safety on MMI area.

  7. Prognostic factors for weight loss over 1-year period in patients recently diagnosed with mild Alzheimer Disease

    DEFF Research Database (Denmark)

    Hansen, M.L.; Waldorff, F.B.; Waldemar, G.;

    2011-01-01

    % in 1 year for defining weight loss. The mean age at inclusion was 76.1 years. Sixty-six patients (24.6%) lost more than 4% of their body weight during the study period. A logistic regression showed that an increase of 1 baseline body mass index point significantly increased the odds of weight loss by 9......%. Furthermore, the results suggested a trend that for men, living alone was a risk factor for losing weight, whereas for women living with somebody was associated with a higher risk. However, further studies are pertinent within this area. As weight loss is a predictor of mortality in patients with AD...

  8. DMPD: The involvement of the interleukin-1 receptor-associated kinases (IRAKs) incellular signaling networks controlling inflammation. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18249132 The involvement of the interleukin-1 receptor-associated kinases (IRAKs) i...2008 Jan 30. (.png) (.svg) (.html) (.csml) Show The involvement of the interleukin-1 receptor-associated kin...ases (IRAKs) incellular signaling networks controlling inflammation. PubmedID 18249132 Title The... involvement of the interleukin-1 receptor-associated kinases (IRAKs) incellular signaling ne

  9. Risk factors and epidemiology of Clostridium difficile infection in hematopoietic stem cell transplant recipients during the peritransplant period.

    Science.gov (United States)

    Aldrete, Sol Del Mar; Kraft, Colleen S; Magee, Matthew J; Chan, Austin; Hutcherson, Don; Langston, Amelia A; Greenwell, Brian I; Burd, Eileen M; Friedman-Moraco, Rachel

    2017-02-01

    Hematopoietic stem cell transplant (HSCT) recipients represent a high-risk group for developing Clostridium difficile (CD) infection (CDI). We aimed to identify specific risk factors for CDI in an HSCT patient population during the peritransplant period. We performed a case-control study within a cohort of HSCT patients who received a transplant from November 2010 to March 2013. Cases had a clinical presentation compatible with CDI and a positive stool sample Xpert(®) C. difficile test. Controls were CDI negative and matched on age, gender, and transplant type. Peritransplant period was defined as -30 days or time of stem cell mobilization maneuver to 30 days post transplant in autologous SCT or 90 days post transplant in allogeneic SCT. Of 781 HSCTs performed during the study period, 650 (83.2%) had a stool sample submitted for CD testing. Eight-six (13.2%) cases with CDI were identified. Most of the cases were diagnosed within a week after transplantation (median of 5 days). In adjusted analysis, prior hospitalization (odds ratio [OR]: 2.01, 95% confidence interval [CI] 1.2-3.36), prior cephalosporin administration (OR 2.72, 95% CI: 1.54-4.83), and prior chemotherapy (OR: 3.26, 95% CI: 1.92-5.5) were significantly associated with CDI. Hospitalization, and prior antibiotic and chemotherapy use are risk factors that are not easily modifiable, which emphasizes the need to start investigating preventive or prophylactic strategies in this high-risk population. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Relationship factors and trajectories of intimate partner violence among South African women during pregnancy and the postpartum period.

    Directory of Open Access Journals (Sweden)

    Allison K Groves

    Full Text Available Intimate partner violence (IPV is a significant public health problem in South Africa. However, there is limited research on whether and how IPV changes during pregnancy and the postpartum period and on the factors that might affect women's risk during this time. In this study, we describe the mean trajectories of physical and psychological IPV during pregnancy and the postpartum period and examine whether relationship power, partner social support, and relationship stress are associated with women's trajectories of IPV. Data come from a longitudinal study with 1,480 women recruited during pregnancy between May 2008 and June 2010 at a public clinic in Durban. Women completed behavioral assessments at their first antenatal visit, at fourteen weeks and at nine months postpartum. Women's experiences of IPV were measured at all three time points and relationship power, partner social support and relationship stress were each measured at the baseline assessment. We used multilevel random coefficients growth modeling to build our models. The mean trajectory for both types of IPV was flat which means that, on average, there was not significant change in levels of IPV over pregnancy and the postpartum period. However, there was significant individual variability in trajectories of IPV over the study period. Women who had higher relationship power had lower levels of physical and psychological IPV over time than women with lower relationship power. Additionally, women with higher relationship stress and lower partner support had higher levels of psychological IPV at pregnancy. Interventions that maximize women's relationship power and partner social support and minimize relationship stress during this transformative time are needed.

  11. The return periods and risk assessment of severe dust storms in Inner Mongolia with consideration of the main contributing factors.

    Science.gov (United States)

    Liu, Xueqin; Li, Ning; Xie, Wei; Wu, Jidong; Zhang, Peng; Ji, Zhonghui

    2012-09-01

    This study presents a methodology for return period analysis and risk assessment of severe dust storm disaster. Meteorological observation data, soil moisture data, and remote sensing data from 30 meteorological stations in Inner Mongolia (western China) from 1985 to 2006 were used for the study. A composite index of severe dust storm disaster (Index I (SDS)) based on the influence mechanisms of the main contributing factors was developed by using the analytic hierarchy process and the weighted comprehensive method, and the hazard risk curves (i.e., the transcendental probability curves of I (SDS)) for the 30 stations were established using the parameter estimation method. We then analyzed the risk of the occurrence of severe dust storm under different scenarios of 5-, 10-, 20-, and 50-year return periods. The results show that the risk decreased from west to east across Inner Mongolia, and there are four severe dust storm occurrence peak value centers, including Guaizihu, Jilantai, Hailisu, and Zhurihe-Erenhot. The severity of dust storms in seven places will be intolerable in the 50-year return period scenario and in three places in the 20-year return period scenario. These results indicate that these locations should concentrate forces on disaster prevention, monitoring, and early warning. The I (SDS) was developed as an easily understandable tool useful for the assessment and comparison of the relative risk of severe dust storm disasters in different areas. The risk assessment was specifically intended to support local and national government agencies in their management of severe dust storm disasters in their efforts to (1) make resource allocation decisions, (2) make high-level planning decisions, and (3) raise public awareness of severe dust storm risk.

  12. Relationship Factors and Trajectories of Intimate Partner Violence among South African Women during Pregnancy and the Postpartum Period

    Science.gov (United States)

    Groves, Allison K.; McNaughton-Reyes, H. Luz; Foshee, Vangie A.; Moodley, Dhayendre; Maman, Suzanne

    2014-01-01

    Intimate partner violence (IPV) is a significant public health problem in South Africa. However, there is limited research on whether and how IPV changes during pregnancy and the postpartum period and on the factors that might affect women's risk during this time. In this study, we describe the mean trajectories of physical and psychological IPV during pregnancy and the postpartum period and examine whether relationship power, partner social support, and relationship stress are associated with women's trajectories of IPV. Data come from a longitudinal study with 1,480 women recruited during pregnancy between May 2008 and June 2010 at a public clinic in Durban. Women completed behavioral assessments at their first antenatal visit, at fourteen weeks and at nine months postpartum. Women's experiences of IPV were measured at all three time points and relationship power, partner social support and relationship stress were each measured at the baseline assessment. We used multilevel random coefficients growth modeling to build our models. The mean trajectory for both types of IPV was flat which means that, on average, there was not significant change in levels of IPV over pregnancy and the postpartum period. However, there was significant individual variability in trajectories of IPV over the study period. Women who had higher relationship power had lower levels of physical and psychological IPV over time than women with lower relationship power. Additionally, women with higher relationship stress and lower partner support had higher levels of psychological IPV at pregnancy. Interventions that maximize women's relationship power and partner social support and minimize relationship stress during this transformative time are needed. PMID:25268363

  13. Relationship factors and trajectories of intimate partner violence among South African women during pregnancy and the postpartum period.

    Science.gov (United States)

    Groves, Allison K; McNaughton-Reyes, H Luz; Foshee, Vangie A; Moodley, Dhayendre; Maman, Suzanne

    2014-01-01

    Intimate partner violence (IPV) is a significant public health problem in South Africa. However, there is limited research on whether and how IPV changes during pregnancy and the postpartum period and on the factors that might affect women's risk during this time. In this study, we describe the mean trajectories of physical and psychological IPV during pregnancy and the postpartum period and examine whether relationship power, partner social support, and relationship stress are associated with women's trajectories of IPV. Data come from a longitudinal study with 1,480 women recruited during pregnancy between May 2008 and June 2010 at a public clinic in Durban. Women completed behavioral assessments at their first antenatal visit, at fourteen weeks and at nine months postpartum. Women's experiences of IPV were measured at all three time points and relationship power, partner social support and relationship stress were each measured at the baseline assessment. We used multilevel random coefficients growth modeling to build our models. The mean trajectory for both types of IPV was flat which means that, on average, there was not significant change in levels of IPV over pregnancy and the postpartum period. However, there was significant individual variability in trajectories of IPV over the study period. Women who had higher relationship power had lower levels of physical and psychological IPV over time than women with lower relationship power. Additionally, women with higher relationship stress and lower partner support had higher levels of psychological IPV at pregnancy. Interventions that maximize women's relationship power and partner social support and minimize relationship stress during this transformative time are needed.

  14. Total working period and other risk factors related to eating protein foods habits among civil pilots in Indonesia

    Directory of Open Access Journals (Sweden)

    Indah Imelda Hutabarat

    2017-07-01

    pilots in Indonesia. Methods: A cross-sectional study using secondary data from the survey of eating, drinking and physical exercise habits among civilian pilots in Indonesia 2016. Data collected were demographic characteristics, physical exercise habits, smoking habits, knowledge, body mass index and flight characteristics. Cox regression analysis was used to analyze the dominant factors associated with protein eating habits. Results: Among 528 pilots aged 19-64 years, 194 (36.74% pilots had excessive protein eating habits . Long working period and body mass index were the dominant risk factors associated with protein eating habit in pilots. Compared to pilots with 1-9 years working period, pilots with 10-40 years working period had 35% lower risk of excessive protein eating habits (RRA = 0.65; 95% CI 0:49 - 0.87. Compared to pilots with normal body mass index, overweight pilots had 34% lower risk of excessive protein eating habits (RRA = 0.66; 95% CI 0:47 - 0.93. Conclusion: Long working period and overweight were protective factors from the risk of excessive protein eating habits Keywords: protein eating habits, total working periode, body mass index, civilian pilots Indonesia

  15. Excess energy and decoherence factor of a qubit coupled to a one-dimensional periodically driven spin chain

    Science.gov (United States)

    Nag, Tanay

    2016-06-01

    We take a central spin model (CSM), consisting of a one-dimensional environmental Ising spin chain and a single qubit connected globally to all the spins of the environment, to study the excess energy (EE) of the environment and the logarithm of decoherence factor namely, generalized fidelity susceptibility per site (GFSS), associated with the qubit under a periodic driving of the transverse field term of environment across its critical point using the Floquet theory. The coupling to the qubit, prepared in a pure state, with the transverse field of the spin chain yields two sets of EE corresponding to the two species of Floquet operators. In the limit of weak coupling, we derive an approximated expression of GFSS after an infinite number of driving period which can successfully estimate the low- and intermediate-frequency behavior of GFSS obtained numerically with a large number of time periods. Our main focus is to analytically investigate the effect of system-environment coupling strength on the EEs and GFSS and relate the behavior of GFSS to EEs as a function of frequency by plausible analytical arguments. We explicitly show that the low-frequency beatinglike pattern of GFSS is an outcome of two frequencies, causing the oscillations in the two branches of EEs, that are dependent on the coupling strength. In the intermediate frequency regime, dip structure observed in GFSS can be justified by the resonance peaks of EEs at those coupling parameter-dependent frequencies; high-frequency saturation behavior of EEs and GFSS are controlled by the same static Hamiltonian and the associated saturation values are related to the coupling strength.

  16. Restoration of nerve growth factor in organs of mice injected with cobra venom followed by specific treatment and reversal period.

    Science.gov (United States)

    Lipps, Binie V

    2002-05-01

    Research from this laboratory reported the decreased levels of endogenously present nerve growth factor (NGF) in organs of mice as a consequence of sub-lethal injection of Naja kaouthia venom. This research reports that the decreased levels of NGF in organs of mice were prevented by (1) specific treatment and (2) restored to normal by a prolonged period. Adult female Balb/c mice were injected intramuscularly (IM) with a sub-lethal dose of cobra venom. The injected mice were divided into five groups. Mice in group I were injected with PBS, group II with anti-cobra venom, and group III with lethal toxin neutralizing factor (LTNF). Mice in group IV were treated IM with synthetic LTNF (LT-10), and mice in group V were treated orally with LT-10. After 24 hr. mice were sacrificed and NGF levels in organ homogenates were assayed and compared with control mice not injected with venom. It was observed that the organs from group I treated with PBS showed a tremendous drop in NGF level in comparison to the organs of the control mice. It was further revealed that the decreased levels of NGF in organs of injected mice were prevented by treatment with anti-cobra venom, LTNF and LT-10 by IM, or oral routes. In the second series of experiments, mice injected with sub-lethal dose of cobra venom were sacrificed after 1, 3, 7, and 10 days, and the organs were assayed for NGF levels. It was observed that the recovery period for normal homeostasis of NGF was between 7 and 10 days in the brain, heart, liver, salivary glands, and ovaries.

  17. ANALYSIS OF PREDISPOSING FACTORS TO ABORTION IN WOMEN OF THE FIRST PERIOD OF MATURE AGE OF DIFFERENT SOMATOTYPES WITH 22 - 27 WEEKS GESTATIONAL PERIOD

    Directory of Open Access Journals (Sweden)

    L. V. Muzurova

    2008-12-01

    Full Text Available Frequency of occurance ofdifferent somatotypes and predisposing factors to abortion in women at the age of 22 to 35 of the 2-nd trimester of pregnancy has been understudy. It is determined the women with different somatotypes are characterized by different frequency of occurance of extragenital and genital pathology

  18. FACTORS CAUSING DIFFERENCES IN THE FINANCIAL REPORTING PRACTICES IN SELECTED SOUTH PACIFIC COUNTRIES IN THE POST-CONVERGENCE PERIOD

    Directory of Open Access Journals (Sweden)

    Parmod Chand

    2008-01-01

    Full Text Available The international accounting literature pays much attention to the clustering of national accounting systems of various countries based on similar financial reporting characteristics. In this paper, we argue that the existing models that cluster countries are substantially incomplete and misleading due to the recent convergence efforts that have taken place. We identify the factors that may be causing differences in both the de jure and de facto aspects of comparability in financial reporting across countries in the post-convergence period. Using four countries from the South Pacific region (Australia, New Zealand, Papua New Guinea and Fiji, we identify three dominant factors that still act as constraints in accounting convergence. These include: (1 the nature of business ownership and the financial system, (2 culture, and (3 the level of accounting education and the experience of professional accountants in each of the different countries. We argue that national and international regulators need to work towards reducing these remaining differences across countries to achieve the objectives of accounting convergence.

  19. Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.

    Directory of Open Access Journals (Sweden)

    Daouda Sissoko

    Full Text Available Although the acute manifestations of Chikungunya virus (CHIKV illness are well-documented, few data exist about the long-term rheumatic outcomes of CHIKV-infected patients. We undertook between June and September 2006 a retrospective cohort study aimed at assessing the course of late rheumatic manifestations and investigating potential risk factors associated with the persistence of these rheumatic manifestations over 15 months. 147 participants (>16 yrs with laboratory-confirmed CHIKV disease diagnosed between March 1 and June 30, 2005, were identified through a surveillance database and interviewed by telephone. At the 15-month-period evaluation after diagnosis, 84 of 147 participants (57% self-reported rheumatic symptoms. Of these 84 patients, 53 (63% reported permanent trouble while 31 (37% had recurrent symptoms. Age > or=45 years (OR = 3.9, 95% CI 1.7-9.7, severe initial joint pain (OR = 4.8, 95% CI 1.9-12.1, and presence of underlying osteoarthritis comorbidity (OR = 2.9, 95% CI 1.1-7.4 were predictors of nonrecovery. Our findings suggest that long-term CHIKV rheumatic manifestations seem to be a frequent underlying post-epidemic condition. Three independent risk factors that may aid in early recognition of patients with the highest risk of presenting prolonged CHIKV illness were identified. Such findings may be particularly useful in the development of future prevention and care strategies for this emerging virus infection.

  20. Evolution of metabolic risk factors over a two-year period in a cohort of first episodes of psychosis.

    Science.gov (United States)

    Bioque, Miquel; García-Portilla, M A Paz; García-Rizo, Clemente; Cabrera, Bibiana; Lobo, Antonio; González-Pinto, Ana; Díaz-Caneja, Covadonga M; Corripio, Iluminada; Vieta, Eduard; Castro-Fornieles, Josefina; Bobes, Julio; Gutiérrez-Fraile, Miguel; Rodriguez-Jimenez, Roberto; Mezquida, Gisela; Llerena, Adrián; Saiz-Ruiz, Jeronimo; Bernardo, Miguel

    2017-06-26

    Patients with a first episode of psychosis (FEP) display a broad range of metabolic risk factors related to the development of diverse medical comorbidities. Initial stages of these disorders are essential in understanding the increased vulnerability of developing cardiometabolic disturbances, associated with a reduced life expectancy. This study aimed to evaluate the metabolic profile of a cohort of patients with a FEP and its evolution during a two year follow-up, as well as the factors that influence the changes in their metabolic status. 16 participating centers from the PEPs Project recruited 335 subjects with a FEP and 253 matched healthy controls, aged 9-35years. We investigated a set of anthropometric measures, vital signs and laboratory data obtained from each participant over two years in a prospective, naturalistic study. From the beginning of the study the FEP group showed differences in the metabolic profile compared to the control group, together with a progressive worsening in the major part of the analyzed variables during the follow-up period, with higher rates of obesity and metabolic syndrome. Certain risk factors were related to determinate clinical variables such as male gender, the presence of affective symptoms or an early onset or to treatment variables such as the use of antipsychotic polypharmacy, antidepressants or mood stabilizers. Our results highlight the extremely high risk of patients at early phases of schizophrenia and other psychotic disorders of developing cardiovascular comorbidity and the fast worsening of the metabolic profile during the first two years. Copyright © 2016 Elsevier B.V. All rights reserved.

  1. [Prevalence of vitamin D deficiency and associated factors in women and newborns in the immediate postpartum period].

    Science.gov (United States)

    do Prado, Mara Rúbia Maciel Cardoso; Oliveira, Fabiana de Cássia Carvalho; Assis, Karine Franklin; Ribeiro, Sarah Aparecida Vieira; do Prado Junior, Pedro Paulo; Sant'Ana, Luciana Ferreira da Rocha; Priore, Silvia Eloiza; Franceschini, Sylvia do Carmo Castro

    2015-01-01

    To assess the prevalence of vitamin D deficiency and its associated factors in women and their newborns in the postpartum period. This cross-sectional study evaluated vitamin D deficiency/insufficiency in 226 women and their newborns in Viçosa (Minas Gerais, BR) between December 2011 and November 2012. Cord blood and venous maternal blood were collected to evaluate the following biochemical parameters: vitamin D, alkaline phosphatase, calcium, phosphorus and parathyroid hormone. Poisson regression analysis, with a confidence interval of 95% was applied to assess vitamin D deficiency and its associated factors. Multiple linear regression analysis was performed to identify factors associated with 25(OH)D deficiency in the newborns and women from the study. The criteria for variable inclusion in the multiple linear regression model was the association with the dependent variable in the simple linear regression analysis, considering p<0.20. Significance level was α<5%. From 226 women included, 200 (88.5%) were 20 to 44 years old; the median age was 28 years. Deficient/insufficient levels of vitamin D were found in 192 (85%) women and in 182 (80.5%) neonates. The maternal 25(OH)D and alkaline phosphatase levels were independently associated with vitamin D deficiency in infants. This study identified a high prevalence of vitamin D deficiency and insufficiency in women and newborns and the association between maternal nutritional status of vitamin D and their infants' vitamin D status. Copyright © 2015 Sociedade de Pediatria de São Paulo. Publicado por Elsevier Editora Ltda. All rights reserved.

  2. Survival of diurnally sub periodic Wuchereria bancrofti in Downsiomyia nivea (Diptera: Culicidae: a density dependent factor from Andaman & Nicobar Islands

    Directory of Open Access Journals (Sweden)

    A N Shriram

    2014-01-01

    Full Text Available Background & objectives: In India, diurnally sub periodic Wuchereria bancrofti transmitted by Downsiomyia nivea is prevalent only in the Nicobar district of Andaman and Nicobar Islands. The ongoing LF elimination programme aims at transmission interruption by bringing down the microfilarie (mf load in the community, which has implication on the parasite load in mosquito vector. Therefore, understanding density dependent constraints on transmission assumes significance from control perspective. The present study was undertaken in Teressa Island to understand the density dependent parasite mortality and survival probability of the parasite Do. nivea. Methods: The entomological data collected from Teressa Island, endemic for the diurnally sub periodic form of W. bancrofti were used to examine the parasite loss and its survival up to infectivity. Patterns of parasite distribution in Do. nivea were examined. Results: Distribution patterns of microfilariae were found to be over dispersed in Do. nivea. The later stages of the parasite in the vector were randomly distributed. Distribution pattern of various filarial larval stages suggested that the loss of parasites occurred as development progressed and was maximal between the first and second stages. Further, both the prevalence of infection and the degree of parasite aggregation in the vector population have fallen significantly with development of parasite stage. Interpretation & conclusions: Results indicate the operation of parasite density dependent mortality of vectors or parasite loss or combination of both. The present study with Aedes transmitted filariasis conducted before launching LF elimination programme in the study area indicates a comparable level of parasite regulation in the vector which has similar implications on the transmission threshold. Thus, the consideration of Aedes with Culex in deriving the critical level of antigen positive for making decisions on cessation of mass drug

  3. A broad slow frequencies band and high slowing down factor by using one-dimensional hybrid periodic/Fibonacci photonic crystals

    Energy Technology Data Exchange (ETDEWEB)

    Ben Ali, N; Kanzari, M, E-mail: naimgi2@yahoo.fr [Photovoltaic and Semiconductor Materials Laboratory, El-Manar University-ENIT PO Box 37, Le belvedere 1002-Tunis (Tunisia)

    2010-11-15

    By using a theoretical model based on Transfer Matrix Method (TMM) for normal incidence simulator, and for serial (S) polarisation, the slowing of light in one-dimensional (1D) hybrid (Fibonacci{sub 1}/periodic/Fibonacci{sub 2}) photonic crystals is studied at visible frequency band. Effects of the periodicity, the non-periodicity and the number of layers of each photonic structure on the slowing down of light are discussed. The higher slowing down factors was obtained by the hybrid Fibonacci{sub 1}/periodic/Fibonacci{sub 2} structures. This slowing down factors is greater than those corresponding to the periodic, the Fibonacci, the Thue-Morse and the Cantor band-gap structures. In addition this hybrid structure gives the possibility to slowing several frequencies

  4. A TIR domain receptor-associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth.

    Science.gov (United States)

    Karody, V R; Le, M; Nelson, S; Meskin, K; Klemm, S; Simpson, P; Hines, R; Sampath, V

    2013-05-01

    To investigate whether single nucleotide polymorphisms (SNPs) in genes encoding the Toll-like receptor (TLR) signaling pathway modulate susceptibility to preterm birth (PTB). Prospective case-control study examining the contribution of nine TLR SNPs to PTB (<37 weeks) and PTB <32 weeks. Genotyping was done on neonatal blood using a multiplexed single-base extension assay. Chi-square test, Fischer's exact test and classification trees were used for data analysis. Preterm infants (n=177) were more likely to be African American (P=0.02), and were more likely to be born to mothers who smoked (P=0.007), had pregnancy-induced hypertension (PIH; P=0.002) and placental abruption (P=0.0004) when compared with term infants (n=146). The TLR2, TLR4, TLR5, TLR9, nuclear factor-kappa B1 (NFκB1), NFκBIA and IRAK1 variants were not associated with PTB whereas the TIR domain receptor-associated protein (TIRAP) variant was more prevalent in term infants when compared with preterm infants born <32 weeks (P=0.004). PTB <32 weeks was more prevalent in infants without the TIRAP variant whose mothers had PIH and did not smoke (P=0.001). Presence of the TIRAP variant protected against PTB <32 weeks (P=0.015) in Caucasian infants. In our study, a TLR pathway adapter variant (TIRAP (rs8177374)) protected against PTB<32 weeks, supporting our hypothesis that genetic variation in the innate immune signaling pathway contributes to altered risk of PTB.

  5. PROLACTIN-INDUCED TYROSINE PHOSPHORYLATION, ACTIVATION AND RECEPTOR ASSOCIATION OF FOCAL ADHESION KINASE (FAK) IN MAMMARY EPITHELIAL CELLS

    Science.gov (United States)

    Prolactin-Induced Tyrosine Phosphorylation, Activation and ReceptorAssociation of Focal Adhesion Kinase (FAK) in Mammary Epithelial Cells. Suzanne E. Fenton1 and Lewis G. Sheffield2. 1U.S. Environmental ProtectionAgency, MD-72, Research Triangle Park, NC 27711, and

  6. Glycine blunts transplantative liver ischemia-reperfusion injury by downregulating interleukin 1 receptor associated kinase-4

    Institute of Scientific and Technical Information of China (English)

    Zuo-jin LIU; Lu-nan YAN; Shen-wei LI; Hai-bo YOU; Jian-ping GONG

    2006-01-01

    Aim: To determine whether glycine could downregulate interleukin 1 receptor associated kinase-4 (IRAK-4) expression to interfere with lipopolysaccharides (LPS) signal transduction and blunt transplantative liver ischemia-reperfusion injury (I/RI). Methods: SD rats were randomly divided into two groups: donor animals of the glycine group (n=40) were given glycine (1.5 mL; 300 mmol/L, iv) 1 h before harvest, and the control group were treated with 1.5 mL physiological saline (n= 40). Orthotropic liver transplantation was then performed according to the Kamada technique. Ten animals in each group were followed up for 7 d after surgery to assess survival. The remaining animals in each group were divided into 3 subgroups (n=10) at 1h, 2 h and 6 h after portal vein reperfusion. Levels of LPS, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and total bilirubin in portal circulation, as well as IRAK-4 and TNF-α expression, NF-кB transcriptional activity and morphological study of liver tissues were analyzed. Results: Reperfusion resulted in a significant elevation of LPS concentrations in each group persisting to the end of our study. However, glycine, which led to improved survival rate and liver function, significantly alleviated liver parenchyma cell damage by downregulating IRAK-4, TNF-α expression and NF-кB transcriptional activity compared with the control group. Conclusion: Glycine can attenuate hepatic I/RI by downregulating IRAK-4 to interfere with LPS signal transduction.

  7. Novel Splice Variants of Bovine Interleukin-1 Receptor-Associated Kinase 2(IRAK2)

    Institute of Scientific and Technical Information of China (English)

    WANG Xing-ping; LUOREN Zhuo-ma; XU Shang-zhong; GAO Xue; LI Jun-ya; REN Hong-yan; CHEN Jin-bao

    2009-01-01

    Interleukin-1 receptor-associated kinases(IRAKs)are important signaling elements of the toll-like receptors family,which play a role in innate immune responses by coordinating host defense mechanisms.Presently different isoforms of human and murine IRAK2 molecules are cloned,but there is no report on the sequences and structure of bovine IRAK2 gene.In this study,we cloned the bovine IRAK2 gene by RT-PCR and RACE and discovered that there exist two alternative splicing of bovine IRAK2 genes,IRAK2a and IRAK2b(GenBank accession no.EU528620 and EU528621).IRAK2a gene is 2148 bp coding 622 aa,which contains a death domain(aa 14-94)and a kinase domain(aa 205-440),but IRAK2b lacks 147 bp of exon 3 corresponding to IRAK2a,and codes 386 aa which contains only partly kinase domain.

  8. APP independent and dependent effects on neurite outgrowth are modulated by the receptor associated protein, RAP

    Science.gov (United States)

    Billnitzer, Andrew J.; Barskaya, Irina; Yin, Cailing; Perez, Ruth G.

    2013-01-01

    Amyloid precursor protein (APP) and its secreted form, sAPP, contribute to the development of neurons in hippocampus, a brain region critical for learning and memory. Full-length APP binds the low-density lipoprotein receptor-related protein (LRP), which stimulates APP endocytosis. LRP also contributes to neurite growth. Furthermore, the receptor associated protein (RAP) binds LRP in a manner that blocks APP-LRP interactions. To elucidate APP contributions to neurite growth for full-length APP and sAPP, we cultured wild type (WT) and APP knockout (KO) neurons in sAPPα and/or RAP and measured neurite outgrowth at 1 day in vitro. Our data reveal that WT neurons had less axonal outgrowth including less axon branching. RAP treatment potentiated the inhibitory effects of APP. KO neurons had significantly more outgrowth and branching, especially in response to RAP, effects which were also associated with ERK2 activation. Our results affirm a major inhibitory role by full-length APP on all aspects of axonal and dendritic outgrowth, and show that RAP-LRP binding stimulated axon growth independently of APP. These findings support a major role for APP as an inhibitor of neurite growth and reveal novel signaling functions for LRP that may be disrupted by Alzheimer’s pathology or therapies aimed at APP processing. PMID:23061396

  9. APP independent and dependent effects on neurite outgrowth are modulated by the receptor associated protein (RAP).

    Science.gov (United States)

    Billnitzer, Andrew J; Barskaya, Irina; Yin, Cailing; Perez, Ruth G

    2013-01-01

    Amyloid precursor protein (APP) and its secreted form, sAPP, contribute to the development of neurons in hippocampus, a brain region critical for learning and memory. Full-length APP binds the low-density lipoprotein receptor-related protein (LRP), which stimulates APP endocytosis. LRP also contributes to neurite growth. Furthermore, the receptor associated protein (RAP) binds LRP in a manner that blocks APP-LRP interactions. To elucidate APP contributions to neurite growth for full-length APP and sAPP, we cultured wild type (WT) and APP knockout (KO) neurons in sAPPα and/or RAP and measured neurite outgrowth at 1 day in vitro. Our data reveal that WT neurons had less axonal outgrowth including less axon branching. RAP treatment potentiated the inhibitory effects of APP. KO neurons had significantly more outgrowth and branching, especially in response to RAP, effects which were also associated with ERK2 activation. Our results affirm a major inhibitory role by full-length APP on all aspects of axonal and dendritic outgrowth, and show that RAP-LRP binding stimulated axon growth independently of APP. These findings support a major role for APP as an inhibitor of neurite growth and reveal novel signaling functions for LRP that may be disrupted by Alzheimer's pathology or therapies aimed at APP processing. © 2012 International Society for Neurochemistry.

  10. Factors affecting the level and pattern of polycyclic aromatic hydrocarbons (PAHs) at Gosan, Korea during a dust period

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Sung-Deuk [School of Urban and Environmental Engineering, Ulsan National Institute of Science and Technology (UNIST), 100, Banyeon-ri, Eonyang-eup, Ulsan 689-798 (Korea, Republic of); Ghim, Young Sung, E-mail: ysghim@hufs.ac.kr [Department of Environmental Science, Hankuk University of Foreign Studies, Wangsan-ri, Mohyeon-myeon, Yongin 449-791 (Korea, Republic of); Lee, Ji Yi [Department of Environmental Engineering, BK21 Team for Biohydrogen Production, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759 (Korea, Republic of); Kim, Jin Young [Center for Environmental Technology Research, Korea Institute of Science and Technology (KIST), Seoul 136-791 (Korea, Republic of); Kim, Yong Pyo [Department of Environmental Science and Engineering, Ewha Womans University, 11-1 Daehyun-dong, Seodaemun-gu, Seoul 120-750 (Korea, Republic of)

    2012-08-15

    Highlights: Black-Right-Pointing-Pointer We collected air samples at a remote site during an Asian dust period. Black-Right-Pointing-Pointer We analyzed levels, patterns, and gas/particle partitioning of PAHs. Black-Right-Pointing-Pointer Particulate PAHs were highly correlated with PM{sub 2.5}. Black-Right-Pointing-Pointer The fraction of particulate PAHs increased during the dust period. Black-Right-Pointing-Pointer Fine particles might be an important carrier of PAHs emitted from China. - Abstract: Polycyclic aromatic hydrocarbons (PAHs) in both gas and total suspended particles were measured at Gosan, Jeju Island in Korea, a remote background site, for 15 days (March 29-April 12, 2002). During the sampling period, a severe three-day Asian dust (AD) event originating from Mongolia and northern China was observed throughout the Korean Peninsula and Jeju Island. In addition, pollution (PO) and normal (NO) periods were also identified based on the levels of anthropogenic pollutants. Despite a large difference of PM{sub 10} concentrations between the AD and PO periods, the levels of particulate PAHs in both periods were comparable (2.7 {+-} 1.0 and 2.4 {+-} 0.5 ng m{sup -3}, respectively) since they were determined by the concentration of anthropogenic PM{sub 2.5} transported from industrial areas of China. In the AD period, the level of gaseous PAHs, which were mostly from local sources, was the lowest due to strong winds; the gas/particle partitioning was close to equilibrium as the effect of long-range transport was manifested. The results of backward air trajectories, correlation analysis, and diagnostic ratios show that long-range transport of particulate PAHs produced by coal/biomass burning in China could strongly affect the levels and patterns of PAHs at Gosan, Korea.

  11. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker.

    Science.gov (United States)

    Zheng, Xiaoyi; Chang, Frank; Zhang, Xinmin; Rothman, Vicki L; Tuszynski, George P

    2012-08-01

    Using an innovative "2-D high performance liquid electrophoresis" (2-D HPLE) technology we identified that a specific fragment of G-protein coupled receptor-associated sorting protein 1 (GASP-1) was present in the sera of breast cancer patients and was over-expressed in early and late stage breast tumors (Tuszynski, G.P. et al., 2011). In this study we further investigated the significance of GASP-1 as a tumor marker by investigating the expression GASP-1 in different kinds of tumors as well as in the sera of patients with various cancers. Over expression of GASP-1 was detected in brain, pancreatic, and breast cancers as compared to their respective normal tissues as assessed by immunohistochemical staining of tissue arrays using a "peptide specific" GASP-1 antibody. We found that across these cancers, GASP-1 was expressed approximately 10 fold more in the cancer as compared to normal tissue. The increase in GASP-1 expression was also seen in hyperplastic and inflammatory lesions of breast and pancreatic cancers as compared to normal tissue. GASP-1 was primarily expressed in the tumor epithelium of the epithelial-derived cancers and in the transformed glial cells of the brain tumors. Using a sensitive "competitive ELISA" for GASP-1, we found that sera from patients with brain, liver, breast and lung cancers expressed 4-7 fold more GASP-1 peptide than sera from normal healthy individuals. These studies identify GASP-1 as a potential new serum and tumor biomarker for several cancers and suggest that GASP-1 may be a novel target for development of cancer therapeutics. Copyright © 2012 Elsevier Inc. All rights reserved.

  12. Factors affecting the duration of nestling period and fledging order in Tengmalm's owl (Aegolius funereus): effect of wing length and hatching sequence.

    Science.gov (United States)

    Kouba, Marek; Bartoš, Luděk; Korpimäki, Erkki; Zárybnická, Markéta

    2015-01-01

    In altricial birds, the nestling period is an important part of the breeding phase because the juveniles may spend quite a long time in the nest, with associated high energy costs for the parents. The length of the nestling period can be variable and its duration may be influenced by both biotic and abiotic factors; however, studies of this have mostly been undertaken on passerine birds. We studied individual duration of nestling period of 98 Tengmalm's owl chicks (Aegolius funereus) at 27 nests during five breeding seasons using a camera and chip system and radio-telemetry. We found the nestlings stayed in the nest box for 27 - 38 days from hatching (mean ± SD, 32.4 ± 2.2 days). The individual duration of nestling period was negatively related to wing length, but no formally significant effect was found for body weight, sex, prey availability and/or weather conditions. The fledging sequence of individual nestlings was primarily related to hatching order; no relationship with wing length and/or other factors was found in this case. We suggest the length of wing is the most important measure of body condition and individual quality in Tengmalm's owl young determining the duration of the nestling period. Other differences from passerines (e.g., the lack of effect of weather or prey availability on nestling period) are considered likely to be due to different life-history traits, in particular different food habits and nesting sites and greater risk of nest predation among passerines.

  13. Periodic Fever: A Review on Clinical, Management and Guideline for Iranian Patients - Part II.

    Science.gov (United States)

    Ahmadinejad, Zahra; Mansouri, Sedigeh; Ziaee, Vahid; Aghighi, Yahya; Moradinejad, Mohammad-Hassan; Fereshteh-Mehregan, Fatemeh

    2014-06-01

    Periodic fever syndromes are a group of diseases characterized by episodes of fever with healthy intervals between febrile episodes. In the first part of this paper, we presented a guideline for approaching patients with periodic fever and reviewed two common disorders with periodic fever in Iranian patients including familial Mediterranean fever (FMF) and periodic fever syndromes except for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA). In this part, we review other autoinflammatory disorders including hyper IgD, tumor necrosis factor receptor-associated periodic syndrome (TRAPS), cryopyrin associated periodic syndromes, autoinflammatory bone disorders and some other rare autoinflammatory disorders such as Sweet's and Blau syndromes. In cryopyrin associated periodic syndromes group, we discussed chronic infantile neurologic cutaneous and articular (CINCA) syndrome, Muckle-Wells syndrome and familial cold autoinflammatory syndrome. Autoinflammatory bone disorders are categorized to monogenic disorders such as pyogenic arthritis, pyoderma ;gangraenosum and acne (PAPA) syndrome, the deficiency of interleukine-1 receptor antagonist (DIRA) and Majeed syndrome and polygenic background or sporadic group such as chronic recurrent multifocal osteomyelitis (CRMO) or synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome are classified in sporadic group. Other autoinflammatory syndromes are rare causes of periodic fever in Iranian system registry.

  14. Frequency and changes in trends of leading risk factors of coronary heart disease in women in the city of Novi Sad during a 20-year period

    Directory of Open Access Journals (Sweden)

    Rakić Dušica

    2012-01-01

    Full Text Available Backround/Aim. From 1984 to 2004 the city of Novi Sad participated through its Health Center “Novi Sad” in the international Multinational MONItoring of Trends and Determinants in CArdiovascular Disease (MONICA project, as one of the 38 research centers in 21 countries around the world. The aim of this study was to determine frequency and changes of trends in leading risk factors of coronary heart disease (CHD and to analyze the previous trend of movement of coronary event in women in Novi Sad during a 20- year period. Methods. In 2004, the fourth survey within MONICA project was conducted in the city of Novi Sad. The representative sample included 1,041 women between the age of 25 and 74. The prevalence of risk factors in CHD such as smoking, high blood pressure, elevated blood cholesterol, elevated blood glucose and obesity was determined. Also, indicators of risk factors and rates of coronary events in women were compared with the results from MONICA project obtained in previous three screens, as well as with the results from other research centres. χ2-test, linear trend and correlartion coefficient were used in statistical analysis of results obtained. Results. It was observed that during a 20-year period covered by the study, the prevalence of the leading risk factors for the development of CHD in the surveyed women was significantly increasing and in positive correlation with the values of linear trend. Also, the increase of morbidity rates and mortality rates of coronary event were in positive correlation. The decrease was only recorded in the period from 1985-1989 (the implementation of the intervention programme. Conclusion. Upon analysing the increase in prevalence of leading risk factors of CHD and significant increase in the rates of coronary event, we can conclude that health status of women in Novi Sad during a 20-year period was deteriorating.

  15. Prognostic factors for weight loss over 1-year period in patients recently diagnosed with mild Alzheimer Disease

    DEFF Research Database (Denmark)

    Hansen, Marie-Louise H; Waldorff, Frans B; Waldemar, Gunhild

    2011-01-01

    The aim of the study was to identify prognostic factors for weight loss in patients recently diagnosed with mild Alzheimer disease (AD), with special emphasis on the patients' social participation and living arrangements. The data used in this study was part of the Danish Alzheimer Intervention...

  16. Prevalence of and Risk Factors for Depressive Symptoms in Korean Women throughout Pregnancy and in Postpartum Period

    Directory of Open Access Journals (Sweden)

    Jeong-hwan Park, PhD, RN

    2015-09-01

    Conclusions: To assist women suffering from postpartum depression and prevent its effects, women should be screened for prenatal depression during all three trimesters. For Korean women with high risk factors for prenatal depression, we suggest that the Korean government establish healthcare policies related to depression screening as routine prenatal care and mental health referral systems.

  17. The Italian public finances in the period 1998-2007: temporary factors, medium-term trends and discretionary measures

    OpenAIRE

    Maria Rosaria Marino; Sandro Momigliano; Pietro Rizza

    2008-01-01

    The paper examines the development of Italy�s public finances after the consolidation period 1992-97, which secured participation in the European Monetary Union from the outset. The �structural� developments in the main budgetary components are assessed, excluding the effects of the economic cycle and of temporary measures. The analysis shows a rapid deterioration in the years 1998-2003, whose roots can be traced back to the consolidation of the early 1990s, achieved primarily by means ...

  18. Survival analysis of factors affecting incidence risk of Salmonella Dublin in Danish dairy herds during a 7-year surveillance period

    DEFF Research Database (Denmark)

    Nielsen, Liza Rosenbaum; Dohoo, Ian

    2012-01-01

    -quarters (YQs), either at the start of the study period or after recovery from infection. Survival analysis was performed on a dataset including 6931 dairy herds with 118969 YQs at risk, in which 1523 failures (new infection events) occurred. Predictors obtained from register data were tested in a multivariable......A national surveillance programme for Salmonella Dublin, based on regular bulk-tank milk antibody screening and movements of cattle, was initiated in Denmark in 2002. From 2002 to end of 2009 the prevalence of test-positive dairy herds was reduced from 26% to 10%. However, new infections and spread...

  19. LACK OF INFORMATION AND IRRESPONSIBILITY AS THE CRUCIAL RISK FACTORS OF EARLY SEXUALITY IN THE ADOLESCENT PERIOD

    Directory of Open Access Journals (Sweden)

    Bozidar Jovanovic

    2004-12-01

    Full Text Available The periods of puberty and adolescence are the complex periods of transition from childhood to maturity during which the young are supposed to understand and control their interest in the opposite sex, gain their independence, get used to the problems that adults have, create their own opinion concerning anything that happens around them and in the world and make their own moral principles.The aim of this research is to clarify the problems of adolescent sexuality. The study includes 2000 secondary school students from Kragujevac (500 male and 1500 female students.The study has shown that young people get most information about sex not at school or from their parents but from magazines, mutual communication, and television.The majority of young people do not even think about the possible consequences of sexual intercourse and are quite irresponsible.They do not take into consideration pregnancy nor any other complications. They have no sufficent knowledge about contraceptive methods and do not apply them.Some prevention can be applied among the young by help of the family, school, and surrounding.

  20. Hyper-IgD syndrome and hereditary periodic fever syndromes

    Directory of Open Access Journals (Sweden)

    L. Vicentini

    2011-09-01

    Full Text Available Hereditary periodic fever syndromes are a group of systemic disorders characterized by recurrent attacks of systemic inflammation (autoinflammation without infectious or autoimmune cause. The hyper-IgD syndrome (HIDS is a rare autosomal recessive inflammatory disorder characterized by recurrent fever, increased serum IgD (normal value < 100 U/ml and generalized inflammation (lymphadenopathy, arthralgias/arthritis, abdominal complaints, skin rash, and headache. The attacks persist during the entire life although frequency and severity tend to diminish with age. HIDS is caused by specific mutations in the gene encoding mevalonate kinase, resulting in depressed enzymatic activity. At present the therapy for the syndrome is only supportive. Other than HIDS, other hereditary systemic inflammatory disorders have been described: the Familial Mediterranean Fever, the tumour necrosis factor receptor associated periodic syndrome (TRAPS, a disease related to the mutations of one of the TNF receptors, the Familial Cold Urticaria and the Muckle-Wells syndrome. The differential diagnosis with other causes of periodic fever is crucial for assessing appropriate management and treatment.

  1. Factors influencing the progress of mobilization in hip fracture patients during the early postsurgical period?-A prospective observational study.

    Science.gov (United States)

    Buecking, Benjamin; Bohl, Katharina; Eschbach, Daphne; Bliemel, Christopher; Aigner, Rene; Balzer-Geldsetzer, Monika; Dodel, Richard; Ruchholtz, Steffen; Debus, Florian

    2015-01-01

    The aim of the present study was to determine the independent factors influencing mobilization progress after geriatric hip fractures. 392 Hip fracture patients older than 60 years were included in this prospective, observational, cohort study. The progress of mobilization was measured with walking ability 4 days post-surgery, ability to climb stairs until discharge and the Tinetti test at discharge. Factors correlated with the progress of mobilization were determined using multivariate analyses. The independent factors influencing walking ability 4 days post-surgery were the pre-fracture Charlson Comorbidity Index (OR=0.834, p=0.005), the American Society of Anesthesiologists Score (OR=0.550, p=0.013), pre-fracture Barthel Index ([BI], OR=1.019, p=0.012) and risk for depression, as measured by the Geriatric Depression Scale, (OR=0.896, p=0.013). The probability of climbing stairs until discharge was influenced by the patient's age (OR=0.840, pTinetti test ad discharge. While pre-fracture co-morbidities and function cannot be changed, the treatment of patients with cognitive impairment and depressive symptoms should be optimized. Efforts should be undertaken to ensure early surgery for all hip fractures. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  2. Period-doubling bifurcation in two-stage power factor correction converters using the method of incremental harmonic balance and Floquet theory

    Science.gov (United States)

    Wang, Fa-Qiang; Zhang, Hao; Ma, Xi-Kui

    2012-02-01

    In this paper, period-doubling bifurcation in a two-stage power factor correction converter is analyzed by using the method of incremental harmonic balance (IHB) and Floquet theory. A two-stage power factor correction converter typically employs a cascade configuration of a pre-regulator boost power factor correction converter with average current mode control to achieve a near unity power factor and a tightly regulated post-regulator DC—DC Buck converter with voltage feedback control to regulate the output voltage. Based on the assumption that the tightly regulated post-regulator DC—DC Buck converter is represented as a constant power sink and some other assumptions, the simplified model of the two-stage power factor correction converter is derived and its approximate periodic solution is calculated by the method of IHB. And then, the stability of the system is investigated by using Floquet theory and the stable boundaries are presented on the selected parameter spaces. Finally, some experimental results are given to confirm the effectiveness of the theoretical analysis.

  3. Period-doubling bifurcation in two-stage power factor correction converters using the method of incremental harmonic balance and Floquet theory

    Institute of Scientific and Technical Information of China (English)

    Wang Fa-Qiang; Zhang Hao; Ma Xi-Kui

    2012-01-01

    In this paper,period-doubling bifurcation in a two-stage power factor correction converter is analyzed by using the method of incremental harmonic balance (IHB) and Floquet theory.A two-stage power factor correction converter typically employs a cascade configuration of a pre-regulator boost power factor correction converter with average current mode control to achieve a near unity power factor and a tightly regulated post-regulator DC-DC Buck converter with voltage feedback control to regulate the output voltage. Based on the assumption that the tightly regulated postregulator DC-DC Buck converter is represented as a constant power sink and some other assumptions,the simplified model of the two-stage power factor correction converter is derived and its approximate periodic solution is calculated by the method of IHB.And then,the stability of the system is investigated by using Floquet theory and the stable boundaries are presented on the selected parameter spaces.Finally,some experimental results are given to confirm the effectiveness of the theoretical analysis.

  4. Toward a periodic table of personality: Mapping personality scales between the five-factor model and the circumplex model.

    Science.gov (United States)

    Woods, Stephen A; Anderson, Neil R

    2016-04-01

    In this study, we examine the structures of 10 personality inventories (PIs) widely used for personnel assessment by mapping the scales of PIs to the lexical Big Five circumplex model resulting in a Periodic Table of Personality. Correlations between 273 scales from 10 internationally popular PIs with independent markers of the lexical Big Five are reported, based on data from samples in 2 countries (United Kingdom, N = 286; United States, N = 1,046), permitting us to map these scales onto the Abridged Big Five Dimensional Circumplex model (Hofstee, de Raad, & Goldberg, 1992). Emerging from our findings we propose a common facet framework derived from the scales of the PIs in our study. These results provide important insights into the literature on criterion-related validity of personality traits, and enable researchers and practitioners to understand how different PI scales converge and diverge and how compound PI scales may be constructed or replicated. Implications for research and practice are considered.

  5. Factors affecting the duration of nestling period and fledging order in Tengmalm's owl (Aegolius funereus: effect of wing length and hatching sequence.

    Directory of Open Access Journals (Sweden)

    Marek Kouba

    Full Text Available In altricial birds, the nestling period is an important part of the breeding phase because the juveniles may spend quite a long time in the nest, with associated high energy costs for the parents. The length of the nestling period can be variable and its duration may be influenced by both biotic and abiotic factors; however, studies of this have mostly been undertaken on passerine birds. We studied individual duration of nestling period of 98 Tengmalm's owl chicks (Aegolius funereus at 27 nests during five breeding seasons using a camera and chip system and radio-telemetry. We found the nestlings stayed in the nest box for 27 - 38 days from hatching (mean ± SD, 32.4 ± 2.2 days. The individual duration of nestling period was negatively related to wing length, but no formally significant effect was found for body weight, sex, prey availability and/or weather conditions. The fledging sequence of individual nestlings was primarily related to hatching order; no relationship with wing length and/or other factors was found in this case. We suggest the length of wing is the most important measure of body condition and individual quality in Tengmalm's owl young determining the duration of the nestling period. Other differences from passerines (e.g., the lack of effect of weather or prey availability on nestling period are considered likely to be due to different life-history traits, in particular different food habits and nesting sites and greater risk of nest predation among passerines.

  6. Data from ‘Cohort Differences in Big Five Personality Factors Over a Period of 25 Years’

    Directory of Open Access Journals (Sweden)

    Iris A. M. Smits

    2013-06-01

    Full Text Available This data set comprises of scores of 8,954 psychology freshmen from the University of Amsterdam (1982-2007 on the ‘Vijf PersoonlijkheidsFactoren Test’ or 5PFT developed by Elshout and Akkerman, which is an instrument to measure the Big Five personality factors Extraversion, Agreeableness, Conscientiousness, Neuroticism, and Openness to Experience. Data were collected during the yearly freshmen-testing program from 1982-2007 and include scores at the level of 70 items that can be used in studies of psychometrics and the nature of personality.

  7. Factors associated with seclusion in a statewide forensic psychiatric service in Australia over a 2-year period.

    Science.gov (United States)

    Thomas, Stuart D M; Daffern, Michael; Martin, Trish; Ogloff, James R P; Thomson, Lindsay D G; Ferguson, Murray

    2009-02-01

    Despite seclusion being described as one of the most ethically- and legally-controversial management options available, it remains a widely-used clinical strategy for managing disruptive, aggressive, and violent behaviour. This study sought to determine how frequently seclusion was used, the common characteristics of those secluded and not secluded, and the degree to which the Level of Service Inventory - Revised: Screening Version (LSI-R: SV) could predict seclusion. The study was retrospective, covering the first 2 years of operation of a statewide forensic psychiatry hospital in Victoria, Australia. Data were collected from individual case files, electronic databases, and paper copies of records pertaining to violent incidents and episodes of seclusion. Eighty five (44%) of the 193 patients admitted during this period were secluded. Those secluded were significantly younger and had a more established psychiatric history. LSI-R: SV scores were significantly and positively associated with being secluded. A statistical model containing three LSI-R: SV items, along with age on admission and psychiatric history, achieved an area under the curve of 0.74. Seclusion is used on a regular basis in response to a range of different forms of aggressive behaviour of different severity. The LSI-R: SV demonstrated moderate-to-good accuracy in predicting seclusion and warrants further research using detailed prospective methodologies.

  8. Early Prognostic Factors for the Progress of Preeclampsia – Our Experience in the Period 2010-2011

    Directory of Open Access Journals (Sweden)

    Mariya Angelova Angelova

    2016-08-01

    Full Text Available AIM: To determine the prognostic value of the low Pregnancy-associated plasma protein A (PAPP-A levels in the early stages of pregnancy (11–13 weeks GA independently and in combination with a Doppler test of the uterine arteries during the second half of pregnancy (22–23 weeks GA. MATERIAL AND METHODS: The study covered the period 2010–2011 and included 106 pregnant women, aged 35–40, with a single child pregnancy. The research excluded pregnant women with anomalies of the fetus, smokers and women taking prophylactically low doses of aspirin. RESULTS: Thirty-six pregnant women had PAPP-A level below 0.4 MoM, whereas 20 of them developed preeclampsia and 7 – early preeclampsia. The combination of the low PAPP-A values and the abnormal Doppler test of the uterine arteries is with a considerably better prognostic value in regards to the risk of developing preeclampsia. CONCLUSION: The Doppler test is a non-invasive, quick and easy method for assessment of the uterine-placental blood flow.

  9. 狂犬病发病潜伏期及其影响因素分析%Analysis of rabies incubation period and its influencing factors

    Institute of Scientific and Technical Information of China (English)

    黄少新

    2013-01-01

    [Objective] To understand the rabies incubation period and its influencing factors,and provide scientific evidence for developing control measures.[Methods] The rabies incubation period and its influence factors were analyzed according to 249 questionnaires of rabies in Guilin City from 2004-2011 by using survival analysis method.[Results] The median incubation period of rabies was 51 days,95% CI (42.7,59.3) days,ranging from 1-3 650 days.Interquartile of incubation period was 69 days.Single variable analysis showed that the exposed way,the site of wound,the wound treatment and inoculation after exposure were related to the rabies incubation period.The incubation periods of cases with animal initiative attack,hurt on head or face,wound treatment by doctor,inoculation after exposure were shorter significantly than those of their corresponding ways.Cox model analysis showed that the wound treatment and inoculation after exposure were the real factors influencing latent period.The incubation periods of cases with wound on head or face was the shortest.The incubation period of cases with inoculation after exposure was shorter significantly than that of no inoculation after exposure.[Conclusion] The virus infection of attack animals,the anti-infected abilities of wounded persons,the opportunity and effect of inoculation are the influencing factors of rabies incubation period.It is suggested to note that the status of animal attacks,and receive timely immunization.%目的 了解狂犬病发病潜伏期及其影响因素,为制定预防控制措施提供科学依据.方法 采用生存分析方法对广西桂林市2004-2011年249份狂犬病个案资料就潜伏期及其影响因素进行分析.结果 桂林市狂犬病发病潜伏期最短1d,最长3 650 d,中位数51d,中位数的95%可信区间为42.7 ~59.3 d,潜伏期的四分位数间距为69 d.单因素分析发现暴露方式、伤口部位、伤口处理以及暴露后有无免疫接种与狂犬病发病的

  10. Molecular Characterization of Two Monoclonal Antibodies against the Same Epitope on B-Cell Receptor Associated Protein 31

    OpenAIRE

    Kim, Won-Tae; Shin, Saemina; Hwang, Hyo Jeong; Kim, Min Kyu; Jung, Han-Sung; Park, Hwangseo; RYU, CHUN JEIH

    2016-01-01

    Previously, we showed that B-cell receptor associated protein 31 (BAP31), an endoplasmic reticulum (ER) membrane chaperone, is also expressed on the cell surface by two monoclonal antibodies (MAbs) 297-D4 and 144-A8. Both MAbs recognize the same linear epitope on the C-terminal domain of BAP31, although they were independently established. Here, flow cytometric analysis showed that 144-A8 had additional binding properties to some cells, as compared to 297-D4. Quantitative antigen binding assa...

  11. Factors associated with intern noncompliance with the 2003 Accreditation Council for Graduate Medical Education’s 30-hour duty period requirement

    Science.gov (United States)

    2012-01-01

    Background In 2003 the Accreditation Council for Graduate Medical Education mandated work hour restrictions. Violations can results in a residency program being cited or placed on probation. Recurrent violations could results in loss of accreditation. We wanted to determine specific intern and workload factors associated with violation of a specific mandate, the 30-hour duty period requirement. Methods Retrospective review of interns’ performance against the 30-hour duty period requirement during inpatient ward rotations at a pediatric residency program between June 24, 2008 and June 23, 2009. The analytical plan included both univariate and multivariable logistic regression analyses. Results Twenty of the 26 (77%) interns had 80 self-reported episodes of continuous work hours greater than 30 hours. In multivariable analysis, noncompliance was inversely associated with the number of prior inpatient rotations (odds ratio: 0.49, 95% confidence interval (0.38, 0.64) per rotation) but directly associated with the total number of patients (odds ratio: 1.30 (1.10, 1.53) per additional patient). The number of admissions on-call, number of admissions after midnight and number of discharges post-call were not significantly associated with noncompliance. The level of noncompliance also varied significantly between interns after accounting for intern experience and workload factors. Subject to limitations in statistical power, we were unable to identify specific intern characteristics, such as demographic variables or examination scores, which account for the variation in noncompliance between interns. Conclusions Both intern and workload factors were associated with pediatric intern noncompliance with the 30-hour duty period requirement during inpatient ward rotations. Residency programs must develop information systems to understand the individual and experience factors associated with noncompliance and implement appropriate interventions to ensure compliance with the

  12. Single and multiple scattering XAFS Debye-Waller factors for crystalline materials using periodic Density Functional Theory

    Energy Technology Data Exchange (ETDEWEB)

    Dimakis, N; Mion, T [Department of Physics and Geology, University of Texas-Pan American, Edinburg, TX 78539 (United States); Bunker, G, E-mail: dimakis@utpa.ed [Department of Biological Chemical and Physical Sciences, Illinois Institute of Technology, Chicago, IL 60616 (United States)

    2009-11-15

    We present an accurate and efficient technique for calculating thermal X-ray absorption fine structure (XAFS) Debye-Waller factors (DWFs) applicable to crystalline materials. Using Density Functional Theory on a 3x3x3 supercell pattern of MnO structure, under the nonlocal hybrid B3LYP functional paired with Gaussian local basis sets, we obtain the normal mode eigenfrequencies and eigenvectors; these parameters are in turn used to calculate single and multiple scattering XAFS DWFs. The DWFs obtained via this technique are temperature dependent expressions and can be used to substantially reduce the number of fitting parameters, when experimental spectra are fitted with a hypothetical structure. The size of the supercell size limits the R-space range that these parameters could be used. Therefore corresponding DWFs for paths outside of this range are calculated using the correlated Debye model. Our method is compared with prior cluster calculations and with corresponding values obtained from fitting experimental XAFS spectra on manganosite with simulated spectra.

  13. Period Cramps

    Science.gov (United States)

    ... Too Tall or Too Short All About Puberty Period Cramps KidsHealth > For Kids > Period Cramps Print A ... re a girl who gets them. What Are Period Cramps? Lots of girls experience cramps before or ...

  14. Expression of insulin-like growth factor binding protein-1 and -2 genes through the perinatal period in the rat.

    Science.gov (United States)

    Babajko, S; Hardouin, S; Segovia, B; Groyer, A; Binoux, M

    1993-06-01

    Insulin-like growth factor binding proteins (IGFBPs) are essential mediators of the bioavailability and biological effects of the IGFs. Liver expression of the rat (r) IGFBP-1 and rIGFBP-2 genes has been characterized between day 16 in utero (16 diu) and 16 days postnatally (+16 dpn). Run-on experiments showed transcriptional activity of the rIGFBP-1 and rIGFBP-2 genes at birth (B) to be 25 and 5 times that at 16 diu, respectively. After B, transcriptional activity of the rIGFBP-1 gene remained high (140% B at +6 dpn), but that of the rIGFBP-2 gene dropped to 70% B by +6 dpn. Northern blot analysis done simultaneously showed rIGFBP-1 messenger RNA (mRNA) levels to increase approximately 50-fold between 16 diu and B, whereas rIGFBP-2 mRNA increased only 5- to 10-fold. rIGFBP-1 mRNA levels decreased after birth, reaching about 20% B by +6 dpn; rIGFBP-2 mRNA, however, remained stable (about 80% B) at least up to +6 dpn. Parallel Western ligand blot and immunoblot analyses of serum rIGFBPs revealed rIGFBP-1 and rIGFBP-2 concentrations to be increased 3- and 2-fold, respectively between 20 diu and B. Maximal expression of rIGFBP-1 was at +1 dpn (220% B), and of rIGFBP-2, at B. Both rIGFBPs then decreased, reaching about 5% B at adulthood. All these data indicate that increased transcriptional activity of the rIGFBP-1 and rIGFBP-2 genes at birth would determine the increased synthesis in the liver and circulating levels of these proteins. In addition, it would seem that post-transcriptional events (reduced half-life of the rIGFBP-1 messenger after birth, translation efficiency of the rIGFBP-2 messenger) modulate transcriptional regulation.

  15. Analysis of Factors Affecting China' s Transition Period Corruption%中国转型期腐败产生的原因分析

    Institute of Scientific and Technical Information of China (English)

    李旭辉

    2011-01-01

    目前我国正处于腐败的高发期,而这种腐败的最大特点就是转型期腐败。转型期腐败的发生有三个产生因素:腐败机会、腐败动机、公共权力过大,同时存在监督机制不到位的制约。%At present, our country is in the period of high corruption. The biggest characteristic of the period is transition corruption. Causes of transition corruption phenomenon include consequences of corruption occurrence which involves chances and motivation etc. and restricting factors of the of supervision mechanism. This paper analyzes the four aspects of corruption, highrisk, the specific reason for the multiple, which can provide some useful help for the governance of corruption.

  16. Assessment of Ex-Vitro Anaerobic Digestion Kinetics of Crop Residues Through First Order Exponential Models: Effect of LAG Phase Period and Curve Factor

    Directory of Open Access Journals (Sweden)

    Abdul Razaque Sahito

    2013-04-01

    Full Text Available Kinetic studies of AD (Anaerobic Digestion process are useful to predict the performance of digesters and design appropriate digesters and also helpful in understanding inhibitory mechanisms of biodegradation. The aim of this study was to assess the anaerobic kinetics of crop residues digestion with buffalo dung. Seven crop residues namely, bagasse, banana plant waste, canola straw, cotton stalks, rice straw, sugarcane trash and wheat straw were selected from the field and were analyzed on MC (Moisture Contents, TS (Total Solids and VS (Volatile Solids with standard methods. In present study, three first order exponential models namely exponential model, exponential lag phase model and exponential curve factor model were used to assess the kinetics of the AD process of crop residues and the effect of lag phase and curve factor was analyzed based on statistical hypothesis testing and on information theory. Assessment of kinetics of the AD of crop residues and buffalo dung follows the first order kinetics. Out of the three models, the simple exponential model was the poorest model, while the first order exponential curve factor model is the best fit model. In addition to statistical hypothesis testing, the exponential curve factor model has least value of AIC (Akaike's Information Criterion and can generate methane production data more accurately. Furthermore, there is an inverse linear relationship between the lag phase period and the curve factor.

  17. Factors associated with the risk of fall in adults in the postoperative period: a cross-sectional study.

    Science.gov (United States)

    Mata, Luciana Regina Ferreira da; Azevedo, Cissa; Policarpo, Aryanne Gabrielle; Moraes, Juliano Teixeira

    2017-06-08

    to assess the factors associated with the risk of fall in patients undergoing surgical procedures. quantitative and cross-sectional study carried out with 257 adult patients in a hospital in the state of Minas Gerais, Brazil. Data were collected using the sociodemographic and clinical questionnaire, the Morse Fall Scale, and the Quality of Recovery Score. Data were submitted to descriptive statistical analysis and multinomial logistic regression. The level of significance was set at 0.05. 35.4% of patients had high risk of falls, 38.9% had moderate risk and 25.7% had low risk. The mean value in the surgical recovery scale was 175.37 points and no patient presented poor surgical recovery. Regarding the results of the bivariate analysis, it was found that age (pacciones de enfermería dirigidas para prevenir el riesgo de caída en el posoperatorio. avaliar os fatores associados ao risco de queda em pacientes submetidos a procedimentos cirúrgicos. estudo quantitativo, transversal, realizado com 257 pacientes adultos em um hospital de Minas Gerais, Brasil. A coleta de dados se deu por meio de um questionário sociodemográfico e clínico, Morse Fall Scale e Quality of Recovery Score. Os dados foram submetidos a análise estatística descritiva e regressão logística multinominal. O nível de significância adotado foi de 0,05. 35,4% dos pacientes apresentaram elevado risco de quedas, 38,9% moderado risco e 25,7% baixo risco. A escala de recuperação cirúrgica indicou valor médio de 175,37 pontos e nenhum paciente apresentou recuperação cirúrgica precária. Em relação aos resultados da análise bivariada, identificou-se que idade (p<0,001), HAS (p<0,001) e diabetes (p=0,017) estiveram associados positivamente com o alto risco de queda e o câncer (p=0,004) esteve associado positivamente com o moderado risco de queda. Já a recuperação cirúrgica (p=0,008) esteve associada inversamente com o alto risco de queda. os resultados deste estudo possibilitaram a

  18. Effect of block-periodized exercise training on bone and coronary heart disease risk factors in early post-menopausal women: a randomized controlled study.

    Science.gov (United States)

    Kemmler, W; Bebenek, M; von Stengel, S; Engelke, K; Kalender, W A

    2013-02-01

    The purpose of this 12 month randomized exercise intervention was to determine the effect of a block-periodized multipurpose exercise program on bone mineral density (BMD) and parameters of the metabolic syndrome (MetS) in early post-menopausal women. Eighty-five subjects (52.3 ± 2.4 years) living in the area of Erlangen (Germany) were randomly assigned into an exercise (EG, n=43) or a wellness-control group (CG: n=42). The EG performed a periodized multipurpose exercise program with 4-6-week blocks of high-intensity bone-specific exercise intermitted by 10-12 weeks of exercise dedicated to increase endurance and reduce cardiac and metabolic risk factors. The CG performed a low-volume/low-intensity "wellness" program to increase well-being. After 12 months, significant exercise effects were observed for the lumbar spine (LS) BMD as assessed by quantitative computed tomography [total BMD (EG: -0.3 ± 2.1% vs CG: -2.1 ± 2.2%, P=0.015); trabecular BMD (EG: -0.7 ± 3.4% vs CG: -4.7 ± 4.9%, P=0.001) and dual-energy x-ray absorptiometry (DXA) (EG: -0.1 ± 2.2% vs CG: -2.0 ± 2.0%, P=0.002)]. However, no significant effects were observed for total hip BMD as assessed by DXA (P=0.152). Although all MetS parameters were favorably affected among the EG, only the effect for waist circumference was significant. In summary, short periods of bone-specific intervention embedded in longer periods of exercises dedicated to improve cardiovascular and metabolic risk factors positively affected BMD at the LS.

  19. Factors affecting spontaneous reduction of corpora lutea and twin embryos during the late embryonic/early fetal period in multiple-ovulating dairy cows.

    Science.gov (United States)

    López-Gatius, F; García-Ispierto, I; Hunter, R H F

    2010-02-01

    Spontaneous reduction of advanced twin embryos has been described in high-producing, Holstein-Fresian (Bos taurus) dairy herds. The first objective of the current study was to determine whether management and cow factors could have an effect on such a reduction in twin pregnancies during the early fetal period. Because loss of a corpus luteum was noted in cows suffering twin reduction, we expanded our study to include multiple-ovulating cows carrying singletons. Pregnancy was diagnosed and confirmed from Days 28 to 34 and 56 to 62 postinsemination. Sixty-nine (23.5%) of 293 pregnant cows with two corpora lutea carrying singletons and 132 (28.4%) of 464 twin pregnancies recorded on first pregnancy diagnosis subsequently lost one of the corpora lutea or one of the embryos, respectively. Thirty-four (25.8%) of the 132 twin pregnancies suffering embryo reduction lost one corpus luteum along with the embryo. Corpus luteum reduction always occurred in the ovary ipsilateral to the gravid horn suffering embryo reduction. Binary logistic regressions were performed considering corpus luteum and embryo reduction as dependent variables in single and twin pregnancies, respectively, and several management- and cow-related factors as independent variables. In cows carrying singletons, the risk of corpus luteum reduction was 14.3 (1/0.07) times lower for a given herd, whereas the interaction season by laterality significantly affected corpus luteum reduction such that in cows with two corpora lutea ipsilateral to the horn of pregnancy, the risk of reduction decreased during the winter period. In cows carrying twins, ipsilateral twin pregnancies were 3.45 (1/0.29) times more likely to undergo the loss of one embryo than bilateral twin pregnancies. As an overall conclusion, both corpora lutea and embryos were vulnerable to the effects of stress factors during the early fetal period in cows maintaining their pregnancies. A strong unilateral relationship between the corpus luteum and

  20. Evolutionary trajectory of channel planforms in the middle Garonne River (Toulouse, SW France) over a 130-year period: Contribution of mixed multiple factor analysis (MFAmix)

    Science.gov (United States)

    David, Mélodie; Labenne, Amaury; Carozza, Jean-Michel; Valette, Philippe

    2016-04-01

    The purpose of this study is to propose a methodological essay for defining evolutionary trajectories of channel planforms and to examine the channel change in the middle Garonne River (southwest France) over a 130-year period. The study focuses on a reach of ~ 90 km situated downstream from the city of Toulouse. A set of four historical maps (1868, 1940s, 1970s, and 2000s) is used to build a geomorphometric diachronic database. Data processing through mixed multiple factor analysis (MFAmix) and hierarchical cluster analysis (HCA) allows distinction between four homogeneous zones within the study reach, depending on their evolutionary trajectories. Channel behavior in the upstream and median zones evolved as of the beginning of the study period (narrowing of the fluvial area, colonization by vegetation, and removal of alluvial bars), likely owing to punctual anthropogenic actions. The downstream zone is characterized by stabilization of the channel and alluvial bar removal over the second half of the twentieth century, coinciding with the campaign undertaken by French local authorities between 1960 and 1984 to protect river banks. The role of climate transition between the Little Ice Age (LIA) and the onset of the Global Warming period (GW) is also discussed. Results generally are consistent with the chronology established for most European rivers.

  1. Postprandial changes in plasma growth hormone, insulin, insulin-like growth factor (IGF)-I, and IGF-binding proteins in coho salmon fasted for varying periods.

    Science.gov (United States)

    Shimizu, Munetaka; Cooper, Kathleen A; Dickhoff, Walton W; Beckman, Brian R

    2009-08-01

    We examined postprandial changes in circulating growth hormone (GH), insulin, insulin-like growth factor (IGF)-I, and IGF-binding proteins (IGFBPs) in yearling coho salmon under different feeding regimes. Fish were initially fasted for 1 day, 1 wk, or 3 wk. Fasted fish were then fed, and blood was collected at 4-h intervals over 26 h. After the various periods of fasting, basal levels of insulin were relatively constant, whereas those of IGF-I, IGFBPs and GH changed in proportion to the duration of the fast. A single meal caused a rapid, large increase in the circulating insulin levels, but the degree of the increase was influenced by the fasting period. IGF-I showed a moderate increase 2 h after the meal but only in the regularly fed fish. Plasma levels of 41-kDa IGFBP were increased in all groups within 6 h after the single meal. The fasting period did not influence the response of 41-kDa IGFBP to the meal. IGFBP-1 and GH decreased after the meal to the same extent among groups regardless of the fasting period. The present study shows that insulin and IGF-I respond differently to long (weeks)- and short (hours)-term nutritional changes in salmon; insulin maintains its basal level but changes acutely in response to food intake, whereas IGF-I adjusts its basal levels to the long-term nutritional status and is less responsive to acute nutritional input. IGFBPs maintain their sensitivity to food intake, even after prolonged fasting, suggesting their critical role in the nutritional regulation of salmon growth.

  2. PRIORITIES IN CONCEPT OF CARDIOVASCULAR RISK FACTORS IN IRRADIATED PATIENTS AT DISTANT PERIOD AFTER CHERNOBYL NUCLEAR DISASTER BASED ON PROSPECTIVE COHORT DATA

    Directory of Open Access Journals (Sweden)

    R. G. Oganov

    2008-01-01

    Full Text Available Aim. To study pathogenetic mechanisms and cardiovascular risk factors prospective cohort study in liquidators of consequences of Chernobyl Nuclear Disaster 13-20 years after an accident.Material and methods. 409 irradiated patients and 224 control patients comparable on the age and gender were involved into two-stage cohort prospective study with 4,5years period of observation. Database included results of standard questionnaires, social and demographic description, education, family status, smoking and alcohol habits, anthropometry, fasting lipids and glucose, blood pressure, ECG, arrhythmias on ECG monitoring, heart rhythm variability, Echocardiography, thyroid ultrasound image, spirometry, transesophageal electrophysiological study of heart conduction system, exercise tests, functional class of ischemic heart disease, stage of arterial hypertension, fatal/nonfatal end-points, as well as neurologist, endocrinologist and cardiologist conclusions. Totally 267 variables were included in the analysis.Results. Spectrum of active cardiovascular risk factors in cohort of irradiated patients was entirely different from this in control patients. Determinative value for irradiated patients was related with night hypersympathetic activity, ANDS syndrome (Autonomic Nervous Dysfunction on hyperSympathetic type and less related with decreased airway conductance in small bronchial tubes.Conclusion. Comparative prospective cohort study in liquidators of consequences of Chernobyl Nuclear Disaster 13-20 years after an accident revealed highly significant new and permanently acting cardiovascular risk factors. These data let to work out appropriate approaches to therapy and prevention of cardiovascular diseases.

  3. The Prevalence and Risk Factors of Paternal Depression from the Antenatal to the Postpartum Period and the Relationships between Antenatal and Postpartum Depression among Fathers in Hong Kong

    Directory of Open Access Journals (Sweden)

    Y. W. Koh

    2014-01-01

    Full Text Available Introduction. Despite the fact that maternal perinatal mental health problems have been extensively studied and addressed to be a significant health problem, the literature on paternal perinatal mental health problems is relatively scarce. The present study aims at determining the prevalence of paternal perinatal depression and identifying the risk factors and the relationship between antenatal and postpartum depression. Methodology. 622 expectant fathers were recruited from regional maternal clinics. The expectant fathers were assessed using standardized and validated psychological instruments on 3 time points including early pregnancy, late pregnancy, and six weeks postpartum. Results. Results showed that a significant proportion of expectant fathers manifested depressive symptoms during the perinatal period. Paternal antenatal depression could significantly predict higher level of paternal postpartum depression. Psychosocial risk factors were consistently associated with paternal depression in different time points. Conclusions. The present study points to the need for greater research and clinical attention to paternal depression given that it is a highly prevalent problem and could be detrimental to their spouse and children development. The present findings contribute to theoretical basis of the prevalence and risk factors of paternal perinatal depression and have implications of the design of effective identification, prevention, and interventions of these clinical problems.

  4. Analysis of Ligand-Receptor Association and Intermediate Transfer Rates in Multienzyme Nanostructures with All-Atom Brownian Dynamics Simulations.

    Science.gov (United States)

    Roberts, Christopher C; Chang, Chia-En A

    2016-08-25

    We present the second-generation GeomBD Brownian dynamics software for determining interenzyme intermediate transfer rates and substrate association rates in biomolecular complexes. Substrate and intermediate association rates for a series of enzymes or biomolecules can be compared between the freely diffusing disorganized configuration and various colocalized or complexed arrangements for kinetic investigation of enhanced intermediate transfer. In addition, enzyme engineering techniques, such as synthetic protein conjugation, can be computationally modeled and analyzed to better understand changes in substrate association relative to native enzymes. Tools are provided to determine nonspecific ligand-receptor association residence times, and to visualize common sites of nonspecific association of substrates on receptor surfaces. To demonstrate features of the software, interenzyme intermediate substrate transfer rate constants are calculated and compared for all-atom models of DNA origami scaffold-bound bienzyme systems of glucose oxidase and horseradish peroxidase. Also, a DNA conjugated horseradish peroxidase enzyme was analyzed for its propensity to increase substrate association rates and substrate local residence times relative to the unmodified enzyme. We also demonstrate the rapid determination and visualization of common sites of nonspecific ligand-receptor association by using HIV-1 protease and an inhibitor, XK263. GeomBD2 accelerates simulations by precomputing van der Waals potential energy grids and electrostatic potential grid maps, and has a flexible and extensible support for all-atom and coarse-grained force fields. Simulation software is written in C++ and utilizes modern parallelization techniques for potential grid preparation and Brownian dynamics simulation processes. Analysis scripts, written in the Python scripting language, are provided for quantitative simulation analysis. GeomBD2 is applicable to the fields of biophysics, bioengineering

  5. Association pattern of interleukin-1 receptor-associated kinase-4 gene polymorphisms with allergic rhinitis in a Han Chinese population.

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    Yuan Zhang

    Full Text Available OBJECTIVE: Interleukin-1 receptor-associated kinase-4 (IRAK-4 encodes a kinase that is essential for NF-kB activation in Toll-like receptor and T-cell receptor signaling pathways, indicating a possible crosstalk between innate and acquired immunities. We attempted to determine whether the polymorphisms in the Interleukin-1 receptor-associated kinase-4 (IRAK-4 gene are associated with allergic rhinitis (AR in the Han Chinese population. METHODS: A population of 379 patients with AR and 333 healthy controls was studied. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE. A total of 11 single nucleotide polymorphisms (SNPs in IRAK-4 were selected and individually genotyped. RESULTS: Significant allelic differences between cases and controls were obtained for the SNP of rs3794262 in the IRAK-4 gene. In the stratified analysis for gender, two SNPs (rs4251431 and rs6582484 in males appeared as significant associations. Subgroup analysis for the presence of different allergen sensitivities displayed associations only in the house dust mite-allergic cohorts (rs3794262, rs4251481. None of the selected SNPs in IRAK-4 was associated with total IgE level. The haplotype analysis indicated GCCTGCGA was significantly associated with AR. The SNP-SNP interaction information analysis indicated that the selected sets of polymorphisms had no synergistic effect. CONCLUSIONS: Our findings did not support the potential contribution of the IRAK-4 gene to serum IgE levels. However, the results demonstrated a gender- and allergen-dependant association pattern between polymorphisms in IRAK-4 and AR in Chinese population.

  6. Retrospective evaluation of all recorded horse race starts in Switzerland during a four year period focusing on discipline-specific risk factors for clinical events.

    Science.gov (United States)

    Schweizer, C; Ramseyer, A; Gerber, V; Christen, G; Burger, D; Wohlfender, F D

    2016-11-01

    Racetrack injuries are of welfare concern and the prevention of injuries is an important goal in many racing jurisdictions. Over the years this has led to more detailed recording of clinical events on racecourses. However, risk factor analyses of clinical events at race meetings have not been previously reported for Switzerland. To identify discipline-specific factors that influence the occurrence of clinical events during race meetings with the ultimate aim of improving the monitoring and safety of racetracks in Switzerland and optimising racehorse welfare. Retrospective study of horse race data collected by the Swiss horse racing association. All race starts (n = 17,670, including 6198 flat, 1257 obstacle and 10,215 trot race starts) recorded over a period of 4 years (2009-2012) were analysed in multivariable mixed effect logistic regression models including horse and racecourse related data. The models were designed to identify discipline-specific factors influencing the occurrence of clinical events on racecourses in Switzerland. Factors influencing the risk of clinical events during races were different for each discipline. The risk of a clinical event in trot racing was lower for racing on a Porphyre sand track than on grass tracks. Horses whose driver was also their trainer had an approximately 2-fold higher risk for clinical events. In obstacle races, longer distances (2401-3300 m and 3301-5400 m, respectively) had a protective effect compared with racing over shorter distances. In flat racing, 5 racecourses reported significantly fewer clinical events. In all 3 disciplines, finishing 8th place or later was associated with clinical events. Changes in management that aim to improve the safety and welfare of racehorses, such as racetrack adaptations, need to be individualised for each discipline. © 2015 EVJ Ltd.

  7. THE INFLUENCE OF CRITICAL PNENOMENA ON THE EDUCATIONAL PROCESS OF CHILDREN AND YOUNG PEOPLE. PART III. "GENERAL SOCIAL FACTORS SHAPING THE EDUCATIONAL PROCESSES OF THE TRANSFORMATION PERIOD"

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    Golbik Ewa

    2010-01-01

    Full Text Available At present, the generation of people born in the eighties, entered the period of their adulthood. The time of their childhood and development was raddled with the time of the highest social tensions, the end of the socialism age, the nascency of the new constitutional transformation, and the changes in almost every aspect of social, economic and political life. The new order was born among conflicts and adversities, which did not come without the influence on the kelter of an average family. All the threats influence the shape of Polish families, and what was noticed by Z. Kwieciński, the educational reactions undertaken in the families are incoherent. If we add often negative, or outright aggressive impact of school and out of school (television, literature etc. factors, it is difficult to be surprised with the miserable educational effects appearing in the form of pathological behaviours touching children and young people.

  8. Reduced levels of brain-derived neurotrophic factor contribute to synaptic imbalance during the critical period of respiratory development in rats.

    Science.gov (United States)

    Gao, Xiu-Ping; Liu, Qiuli; Nair, Bindu; Wong-Riley, Margaret T T

    2014-07-01

    Previously, our electrophysiological studies revealed a transient imbalance between suppressed excitation and enhanced inhibition in hypoglossal motoneurons of rats on postnatal days (P) 12-13, a critical period when abrupt neurochemical, metabolic, ventilatory and physiological changes occur in the respiratory system. The mechanism underlying the imbalance is poorly understood. We hypothesised that the imbalance was contributed by a reduced expression of brain-derived neurotrophic factor (BDNF), which normally enhances excitation and suppresses inhibition. We also hypothesised that exogenous BDNF would partially reverse this synaptic imbalance. Immunohistochemistry/single-neuron optical densitometry, real-time quantitative PCR (RT-qPCR) and whole-cell patch-clamp recordings were done on hypoglossal motoneurons in brainstem slices of rats during the first three postnatal weeks. Our results indicated that: (1) the levels of BDNF and its high-affinity tyrosine receptor kinase B (TrkB) receptor mRNAs and proteins were relatively high during the first 1-1.5 postnatal weeks, but dropped precipitously at P12-13 before rising again afterwards; (2) exogenous BDNF significantly increased the normally lowered frequency of spontaneous excitatory postsynaptic currents but decreased the normally heightened amplitude and frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) during the critical period; (3) exogenous BDNF also decreased the normally heightened frequency of miniature IPSCs at P12-13; and (4) the effect of exogenous BDNF was partially blocked by K252a, a TrkB receptor antagonist. Thus, our results are consistent with our hypothesis that BDNF and TrkB play an important role in the synaptic imbalance during the critical period. This may have significant implications for the mechanism underlying sudden infant death syndrome.

  9. Factors Affecting the 7Be Concentration in Surface Air Over a Long Period of Monitoring in São Paulo, Brazil

    Science.gov (United States)

    Damatto, S.; Maduar, M.; Pecequilo, B.; Nogueira, P.; Nisti, M.

    2014-12-01

    Beryllium-7 (T1/2 = 53.3 days), a cosmogenic radionuclide produced continuosly in the upper atmosphere by cosmic ray spallation reactions with oxygen and nitrogen can be found in different compartments of the environment and its concentration is influenced by several factors, such as, temperature, precipitation, air velocity, air masses, altitude and as well as latitude. It is quickly attached to aerosols after its formation, becoming a useful tool to study the dynamics of aerosol particles in the atmosphere. Long-term measurements of the spatial and temporal variation of 7Be allows assessment of the influence of these factors. Data of 7Be concentrations in rainfall, air surface, soil and sediments are very well reported in Northern Hemisphere; however these same results are limited in Southern Hemisphere. During a period of 13 years, from October 2001 to October 2014, 7Be concentration was measured every 15 days in surface air at Instituto de Pesquisas Energéticas e Nucleares (IPEN), in the city of São Paulo, São Paulo, Brazil. IPEN campus is located approximately 10 km west from downtown of the city of São Paulo, which is situated on a plateau in Southeastern Brazil, at latitude 23°33'58.27"S and longitude 46°44'14.82"W and an average altitude of 760m above sea level. The climate in the area is temperate tropical with dry period in winter and rainy in summer. The concentrations of 7Be in air filters were measured by non-destructive g-ray spectrometry using a coaxial Be-layer HPGe detector with 15% relative efficiency and live counting time ranged from 100,000s to 250,000 s. The results obtained were correlated to seasons, rainfall, temperature and sunspot number. The concentrations displayed clearly seasonal variations with higher values in spring and summer time and with the amount of precipitation.

  10. Variability of 137Cs and 40K soil-to-fruit transfer factor in tropical lemon trees during the fruit development period.

    Science.gov (United States)

    Velasco, H; Cid, A S; Anjos, R M; Zamboni, C B; Rizzotto, M; Valladares, D L; Juri Ayub, J

    2012-02-01

    In this investigation we evaluate the soil uptake of (137)Cs and (40)K by tropical plants and their consequent translocation to fruits, by calculating the soil-to-fruit transfer factors defined as F(v) = [concentration of radionuclide in fruit (Bq kg(-1) dry mass)/concentration of radionuclide in soil (Bq kg(-1) dry mass in upper 20 cm)]. In order to obtain F(v) values, the accumulation of these radionuclides in fruits of lemon trees (Citrus limon B.) during the fruit growth was measured. A mathematical model was calibrated from the experimental data allowing simulating the incorporation process of these radionuclides by fruits. Although the fruit incorporates a lot more potassium than cesium, both radionuclides present similar absorption patterns during the entire growth period. F(v) ranged from 0.54 to 1.02 for (40)K and from 0.02 to 0.06 for (137)Cs. Maximum F(v) values are reached at the initial time of fruit growth and decrease as the fruit develops, being lowest at the maturation period. As a result of applying the model a decreasing exponential function is derived for F(v) as time increases. The agreement between the theoretical approach and the experimental values is satisfactory.

  11. Periodic paralysis.

    Science.gov (United States)

    Fontaine, Bertrand

    2008-01-01

    Periodic paralyses are rare diseases characterized by severe episodes of muscle weakness concomitant to variations in blood potassium levels. It is thus usual to differentiate hypokalemic, normokalemic, and hyperkalemic periodic paralysis. Except for thyrotoxic hypokalemic periodic paralysis and periodic paralyses secondary to permanent changes of blood potassium levels, all of these diseases are of genetic origin, transmitted with an autosomal-dominant mode of inheritance. Periodic paralyses are channelopathies, that is, diseases caused by mutations in genes encoding ion channels. The culprit genes encode for potassium, calcium, and sodium channels. Mutations of the potassium and calcium channel genes cause periodic paralysis of the same type (Andersen-Tawil syndrome or hypokalemic periodic paralysis). In contrast, distinct mutations in the muscle sodium channel gene are responsible for all different types of periodic paralyses (hyper-, normo-, and hypokalemic). The physiological consequences of the mutations have been studied by patch-clamp techniques and electromyography (EMG). Globally speaking, ion channel mutations modify the cycle of muscle membrane excitability which results in a loss of function (paralysis). Clinical physiological studies using EMG have shown a good correlation between symptoms and EMG parameters, enabling the description of patterns that greatly enhance molecular diagnosis accuracy. The understanding of the genetics and pathophysiology of periodic paralysis has contributed to refine and rationalize therapeutic intervention and will be without doubts the basis of further advances.

  12. Cardiovascular risk factors determined via the Internet in 2 periods of time: 2004–2009 and 2010–2015 in Poland

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    Bartosz G. Trzeciak

    2017-06-01

    Full Text Available Objectives: Web information systems may serve as a diagnostic tool for the Internet users and they also support the epidemiological work of doctors and health care providers. As part of this study, a system has been created for detecting and calculating cardiovascular risk. The aim of this study has been the comparison of cardiovascular risk factors and calculated fatal cardiovascular risk in 2 periods of time: 2004–2009 and 2010–2015 in Poland, as determined via the Internet. Material and Methods: The “Ryzyko program” (“Risk program” is available on the website of the Medical University of Gdańsk. To assess the cardiovascular death risk in a 10-year period, the algorithm of the SCORE (Systematic Coronary Risk Evaluation project was used and 30 402 results of the algorithm have been analyzed. Results: Over 30 402 webpage visitors entered the required data and received the outcome. More than 78% of the Internet users who had entered the data, received a recommendation for medical check-up. Significant differences between the data collected in 2004– 2009 and 2010–2015 were noticed. Hypercholesterolemia prevalence (67.3% vs. 70.8%; p < 0.001, mean total cholesterol concentration in blood (5.60±1.65 mml/l vs. 5.66±1.35 mml/l; p < 0.001, prevalence of hypertension (36.6% vs. 35.3%; p = 0.039, mean systolic blood pressure (131.5±20.3 mm Hg vs. 132.6±18.0 mm Hg; p < 0.001, prevalence of declared smoking (30.7% vs. 26.5%; p < 0.001, declared diabetes mellitus (DM (6.4% vs. 9.7%; p < 0.001, and declared coronary artery disease (CAD (7.2% vs. 14.1%; p < 0.001, respectively. Conclusions: The prevalence of cardiovascular risk factors has changed during the observed period of time. Online automatic gathering of new data by “Ryzyko program” provides up-to-date observations. Int J Occup Med Environ Health 2017;30(3:499–510

  13. Influence of climatic factors on the low yields of spring barley and winter wheat in Southern Moravia (Czech Republic) during the 1961-2007 period

    Science.gov (United States)

    Kolář, Petr; Trnka, Miroslav; Brázdil, Rudolf; Hlavinka, Petr

    2014-08-01

    The paper aims to study the variability of spring barley and winter wheat yields, the most important crops in the Czech Republic, with respect to the variability of weather and climatic factors. Yields of both crops have been studied for 13 districts in Southern Moravia for the 1961-2007 period. From detrended series of spring barley and winter wheat yields, years with very low (lower than the mean minus a 2.5-multiple of the standard deviation) and extremely low (interval given by the mean minus a 1.5- and 2.5-multiple of the standard deviation) yields were selected. Years in which at least one of the districts had extremely low/very low yields were further analyzed. From 10 such years selected separately for spring barley and winter wheat, six of them agreed for both crops. Extreme years were studied using NUTS4-level yield data with respect to temperature, precipitation, the self-calibrated Palmer Drought Severity Index (scPDSI), snow cover, frost patterns, and the onset and duration of select phenophases. Extremely/very low barley yields in 1993, 2000, and 2007 were related to high April-June (AMJ) temperatures, low AMJ precipitation totals, and negative AMJ scPDSI (indicating drought) with an earlier onset of flowering and full ripeness and shorter intervals from tillering to flowering and from flowering to full ripeness compared to the entire 1961-2007 mean. As for extremely/very low winter wheat yields, in addition to the previously mentioned factors, winter patterns also played an important role, particularly the occurrence of severe frosts with a coinciding lack of snow cover and a long-lasting snow cover (in highlands), indicating that low yields are the result of not only one unfavorable factor but a combination of several of them.

  14. Innate immune interleukin-1 receptor-associated kinase 4 exacerbates viral myocarditis by reducing CCR5(+) CD11b(+) monocyte migration and impairing interferon production.

    Science.gov (United States)

    Valaperti, Alan; Nishii, Mototsugu; Liu, Youan; Naito, Kotaro; Chan, Megan; Zhang, Liyong; Skurk, Carsten; Schultheiss, Heinz-Peter; Wells, George A; Eriksson, Urs; Liu, Peter P

    2013-10-01

    Viral myocarditis follows a fatal course in ≈30% of patients. Interleukin-1 receptor-associated kinase 4 (IRAK4), a major nodal signal transducer in innate immunity, can play a pivotal role in host inflammatory response. We sought to determine how IRAK4 modulates inflammation and outcome in a mouse model of viral myocarditis. Myocarditis was induced after intraperitoneal inoculation of coxsackievirus B3 into C57Bl/6 IRAK4-deficient mice and their littermate controls. Mortality and viral proliferation were markedly reduced in IRAK4(-/-) mice compared with their IRAK4(+/+) littermates. Disease resistance of IRAK4(-/-) mice paralleled increased amounts of protective heart-infiltrating CCR5(+) monocytes/macrophages and enhanced interferon-α and interferon-γ production 2 days after infection. Competitive bone marrow chimera demonstrated that intact IRAK4 function inhibited heart-specific migration of bone marrow-derived CCR5(+) cells. Mechanistically, lack of IRAK4 resulted in interferon regulatory factor 5 homodimerization via reduced melanoma differentiation-associated protein 5 degradation and enhanced Stat1 and Stat5 phosphorylation. Consequently, antiviral interferon-α and interferon-γ production, as well as CCR5(+) cell recruitment, increased, whereas the overall proinflammatory response was drastically reduced in the absence of IRAK4. Innate immunity signal transducer IRAK4 exacerbates viral myocarditis through inhibition of interferon production and reduced mobilization of protective CCR5(+) monocytes/macrophages to the heart. The combination of IRAK4 inhibitors and antiviral adjuvants may become an attractive therapeutic approach against viral myocarditis in the future.

  15. Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro.

    Science.gov (United States)

    Yang, Y-F; Chen, Z; Hu, S-L; Hu, J; Li, B; Li, J-T; Wei, L-J; Qian, Z-M; Lin, J-K; Feng, H; Zhu, G

    2011-11-24

    Neuronal Toll-like receptors (TLRs)-2 and -4 have been shown to play a pivotal role in ischemic brain injury, and the interleukin-1 receptor associated kinases (IRAKs) are considered to be the key signaling molecules involved downstream of TLRs. Here, we investigated the expression levels of IRAK-1 and -4 and the effects of IRAK-1/4 inhibition on brain ischemic insult and neuronal hypoxia-induced injury. Male Sprague-Dawley (SD) rats and the rat neuroblastoma B35 cell line were used in these experiments. Permanent middle cerebral artery occlusion (MCAO) was induced by the intraluminal filament technique, and B35 cells were stimulated with the hypoxia-mimetic, cobalt chloride (CoCl(2)). Following induction of hypoxia/ischemia (H/I), B35 cells and cerebral cortical neurons expressed higher levels of IRAK-1 and -4. Furthermore, IRAK-1/4 inhibition decreased the mortality rate, functional deficits, and ischemic infarct volume by 7 days after MCAO. Similarly, IRAK-1/4 inhibition attenuated CoCl(2)-induced cytotoxicity and apoptosis in B35 cells in vitro. Our results show that IRAK-1/4 inhibition decreased the nuclear translocation of the nuclear factor-kappaB (NF-κB) p65 subunit, the levels of activated (phosphorylated) c-jun N-terminal kinase (JNK) and cleaved caspase-3, and the secretion of TNF-α and IL-6 in B35 cells at 6 h after CoCl(2) treatment. These data suggest that IRAK-1/4 inhibition plays a neuroprotective role in H/I-induced brain injury.

  16. Periodic fever syndromes in Eastern and Central European countries: results of a pediatric multinational survey

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    Stefan Mariana

    2010-12-01

    Full Text Available Abstract Objective To analyze the prevalence of diagnosed and suspected autoinflammatory diseases in Eastern and Central European (ECE countries, with a particular interest on the diagnostic facilities in these countries. Methods Two different strategies were used to collect data on patients with periodic fever syndromes from ECE countries- the Eurofever survey and collection of data with the structured questionnaire. Results Data from 35 centers in 14 ECE countries were collected. All together there were 11 patients reported with genetically confirmed familial Mediterranean fever (FMF, 14 with mevalonate-kinase deficiency (MKD, 11 with tumor necrosis factor receptor associated periodic syndrome (TRAPS and 4 with chronic infantile neurological cutaneous and articular syndrome (CINCA. Significantly higher numbers were reported for suspected cases which were not genetically tested. All together there were 49 suspected FMF patients reported, 24 MKD, 16 TRAPS, 7 CINCA and 2 suspected Muckle-Wells syndrome (MWS patients. Conclusions The number of genetically confirmed patients with periodic fever syndromes in ECE countries is very low. In order to identify more patients in the future, it is important to organize educational programs for increasing the knowledge on these diseases and to establish a network for genetic testing of periodic fever syndromes in ECE countries.

  17. Irregular Periods

    Science.gov (United States)

    ... blood become too low or too high. Some women have irregular periods because their bodies produce too much androgen, which is a hormone that causes increased muscle mass, facial hair, and deepening of the voice in males and ...

  18. Period Pain

    Science.gov (United States)

    ... You may also have other symptoms, such as lower back pain, nausea, diarrhea, and headaches. Period pain is not ... Taking a hot bath Doing relaxation techniques, including yoga and meditation You might also try taking over- ...

  19. Factors influencing uptake of contraceptive implants in the immediate postpartum period among HIV infected and uninfected women at two Kenyan District Hospitals.

    Science.gov (United States)

    Shabiby, Mufida M; Karanja, Joseph G; Odawa, Francis; Kosgei, Rose; Kibore, Minnie W; Kiarie, James N; Kinuthia, John

    2015-08-19

    Family planning is a cost effective strategy for prevention of mother to child transmission of HIV and reduction of maternal/infant morbidity and mortality. Contraceptive implants are a safe, effective, long term and reversible family planning method whose use remains low in Kenya. We therefore set out to determine and compare the uptake, and factors influencing uptake of immediate postpartum contraceptive implants among HIV infected and uninfected women at two hospitals in Kenya. This cross sectional study targeted postpartum mothers at two Kenyan district hospitals (one urban and one rural). All participants received general family planning and method specific (Implant) counseling followed by immediate insertion of contraceptive implants to those who consented. The data was analyzed by descriptive analysis, T-test, Chi square tests and logistic regression. One hundred eighty-five participants were enrolled (91 HIV positive and 94 HIV negative) with a mean age of 26 years. HIV positive mothers were significantly older (27.5 years) than their HIV negative counterparts (24.5 years), P = 0.001. The two groups were comparable in education, employment, marital status and religious affiliation. Overall, the uptake of contraceptive implants in the immediate postpartum period was 50.3% and higher among HIV negative than HIV positive participants (57% vs. 43%, P = 0.046). Multivariate analysis revealed that a negative HIV status (P = 0.017) and prior knowledge of contraceptive implants (P = 0.001) were independently associated with increased uptake of contraceptive implants. There was a high uptake of immediate postpartum contraceptive implants among both HIV infected and un-infected women; efforts therefore need to be made in promoting this method of family planning in Kenya and providing this method to women in the immediate postpartum period so as to utilize this critical opportunity to increase uptake and reduce the high unmet need for family planning.

  20. The urokinase plasminogen activator receptor-associated protein/endo180 is coexpressed with its interaction partners urokinase plasminogen activator receptor and matrix metalloprotease-13 during osteogenesis

    DEFF Research Database (Denmark)

    Engelholm, L H; Nielsen, B S; Netzel-Arnett, S

    2001-01-01

    The urokinase plasminogen activator receptor-associated protein/Endo180 (uPARAP/Endo180) is a newly discovered member of the macrophage mannose receptor family that was reported to interact with ligand-bound urokinase plasminogen activator receptor (uPAR), matrix metalloprotease-13 (MMP-13), and ...

  1. Factors associated with maternal near miss in childbirth and the postpartum period: findings from the birth in Brazil National Survey, 2011–2012

    Directory of Open Access Journals (Sweden)

    Rosa Maria Soares Madeira Domingues

    2016-10-01

    Full Text Available Abstract Background Maternal near-miss (MNM audits are considered a useful approach to improving maternal healthcare. The aim of this study was to evaluate the factors associated with maternal near-miss cases in childbirth and the postpartum period in Brazil. Methods The study is based on data from a nationwide hospital-based survey of 23,894 women conducted in 2011–2012. The data are from interviews with mothers during the postpartum period and from hospital medical files. Univariate and multivariable logistic regressions were performed to analyze factors associated with MNM, including estimation of crude and adjusted odds ratios and their respective 95 % confidence intervals (95 % CI. Results The estimated incidence of MNM was 10.2/1,000 live births (95 % CI: 7.5–13.7. In the adjusted analyses, MNM was associated with the absence of antenatal care (OR: 4.65; 95 % CI: 1.51–14.31, search for two or more services before admission to delivery care (OR: 4.49; 95 % CI: 2.12–9.52, obstetric complications (OR: 9.29; 95 % CI: 6.69–12.90, and type of birth: elective C-section (OR: 2.54; 95 % CI: 1.67–3.88 and forceps (OR: 9.37; 95 % CI: 4.01–21.91. Social and demographic maternal characteristics were not associated with MNM, although women who self-reported as white and women with higher schooling had better access to antenatal and maternity care services. Conclusion The high proportion of elective C-sections performed among women in better social and economic situations in Brazil is likely attenuating the benefits that could be realized from improved prenatal care and greater access to maternity services. Strategies for reducing the rate of MNM in Brazil should focus on: 1 increasing access to prenatal care and delivery care, particularly among women who are at greater social and economic risk and 2 reducing the rate of elective cesarean section, particularly among women who receive services at private maternity facilities, where

  2. 妊娠期糖代谢异常的相关危险因素分析%Risk Factors of Abnormal Glucose Metabolism in Gestation Period

    Institute of Scientific and Technical Information of China (English)

    代明甫; 李倩; 钟思燕; 杨霜雪; 邬小臣

    2015-01-01

    Objective:To explore risk factors of abnormal glucose metabolism in gestation period, and provide the theory basis for the clinical prevention and treatment of gestational diabetes mellitus ( GDM ) . Method:A case-control study was conducted on 100 pregnant women with clinically confirmed gestational abnormal glucose metabolism as study group, and 100 pregnant women of same gestational weeks with normal glucose metabolism as control group from Jun.2011 to May 2014.The general information, gestational mate-rials and behaviors of the two groups were investigated and the risk factors of abnormal glucose metabolism in gestation period were analyzed.Result:Multi-factor logistic regression analysis showed that diabetes family history ( OR =2.398, 95%CI 1.042~5.012) , age was more than 28 years ( OR=1.413, 95%CI 1.322~4. 352) , BMI>24 ( OR=6.543, 95%CI 0.782~2.320) , abortion history ( OR=0.212, 95%CI 0.025~2. 256) , smoking history ( OR=0.246, 95%CI 0.045~3.452) were the risk factor of GDM morbidity.Con-clusion:Pregnant women with diabetes family history,>28 years, BMI>24,history of abortion and smoking should undergo gestational diabetes screening during early trimester of pregency.%目的:探讨妇女妊娠期糖代谢异常分布情况及发病的相关危险因素,为预防和控制妊娠期糖尿病提供理论依据。方法:以我院2011年6月至2014年5月保健门诊确诊的妊娠期糖代谢异常的孕产妇100例为病例组,以糖代谢正常及孕周相同的孕产妇100例为对照组。调查两组孕产妇一般情况,分析妊娠期糖代谢异常相关因素。结果:Logistic回归分析发现糖尿病遗传史( OR=2.398,95%, CI:1.042~5.012)、年龄>28岁( OR=1.413,95%,CI:1.322~4.352)、体质指数>24( OR=6.543,95%, CI:0.782~2.320)、流产史( OR=0.212,95%,CI:0.025~2.256)、吸烟史( OR=0.246,95%,CI:0.045~3.452)是妊娠

  3. Molecular cloning and expression analysis of GABA(A) receptor-associated protein (GABARAP) from small abalone, Haliotis diversicolor.

    Science.gov (United States)

    Bai, Rongyao; You, Weiwei; Chen, Jun; Huang, Heqing; Ke, Caihuan

    2012-10-01

    GABA(A) receptor-associated protein (GABARAP), a multifunctional protein participating in autophagy process, is evolutionarily conserved and involves in innate immunity in eukaryotic cells, but currently there is no research on the relationship between GABARAP and innate immunity in mollusc. In the present study, the GABARAP full-length cDNA and its genomic DNA were firstly cloned from small abalone (Haliotis diversicolor), which was named as saGABARAP. Its full-length cDNA is 963 bp with a 354 bp open reading frame encoding a protein of 117 aa, a 276 bp 5'-UTR, and a 333 bp 3'-UTR including a poly(A) tail, two typical polyadenylation signals (AATAA) and two RNA instability motifs (ATTTA). The deduced protein has an estimated molecular weight of 13.9 kDa and a predicted PI of 8.73. Its genomic DNA comprises 4352 bp, containing three exons and two introns. Quantitative real-time PCR analysis revealed that saGABARAP was constitutively expressed in all examined tissues, with the highest expression level in hepatopancreas, and was upregulated in hepatopancreas and hemocytes after bacterial challenge. In addition, saGABARAP was ubiquitously expressed at all examined embryonic and larval development stages. These results suggested that saGABARAP could respond to bacteria challenge and may play a vital role in the adult innate immune system against pathogens and the development process of abalone embryo and larvae.

  4. INHIBITORY EFFECT OF ANGIOTENSIN Ⅱ TYPE 1 RECEPTOR-ASSOCIATED PROTEIN ON VASCULAR SMOOTH MUSCLE CELL GROWTH AND NEOINTIMAL FORMATION

    Institute of Scientific and Technical Information of China (English)

    Zhen Li; Zhong-gao Wang; Xiu Chen; Xiao-dong Chen

    2007-01-01

    Objective To investigate the mechanism of a novel angiotensin n type 1 receptor-associated protein (ATRAP) interfering with angiotensin Ⅱ type 1 (AT1) receptor-mediated vascular smooth muscle cell (VSMC) growth and neointimal formation. Methods VSMCs isolated from thoracic aorta of adult Sprague-Dawley ( SD) rats were used in this study. ATRAP Cdna was subcloned into pcDNA3 vector and then transfected into VSMCs. DNA synthesis and extracellular signal-regulated kinase (ERK) and phospho-ERK expressions in VSMCs were assayed by measurement of 3H thymidine incorporation and Western blotting, respectively. Morphological changes were observed in the balloon injured artery with or without transfection of ATRAP Cdna using 12-week-old male SD rats. Results ATRAP overexpression in VSMCs inhibited angiotensin Ⅱ (Ang Ⅱ) -induced 3H thymidine incorporation 48 hours after Ang Ⅱ stimulation (P < 0.05). In VSMC, Ang Ⅱ stimulation increased the phosphorylation of ERK, which reached the peak around 60 minutes. The activation of phospho-ERK was significantly decreased by ATRAP (P < 0.05). Neointimal formation was markedly inhibited by ATRAP overexpression in injuried arteries. Conclusions The AT1 receptor-derived activation of ERK plays an essential role in Ang Ⅱ-induced VSMC growth. The growth inhibitory effects of ATRAP might be due to interfering with AT1 receptor-mediated activation of ERK in VSMC growth and neointimal formation.

  5. Characterization of Receptor-Associated Protein Complex Assembly in Interleukin (IL)-2- and IL-15-Activated T-Cell Lines.

    Science.gov (United States)

    Osinalde, Nerea; Sanchez-Quiles, Virginia; Akimov, Vyacheslav; Aloria, Kerman; Arizmendi, Jesus M; Blagoev, Blagoy; Kratchmarova, Irina

    2017-01-06

    It remains a paradox that IL-2 and IL-15 can differentially modulate the immune response using the same signaling receptors. We have previously dissected the phosphotyrosine-driven signaling cascades triggered by both cytokines in Kit225 T-cells, unveiling subtle differences that may contribute to their functional dichotomy. In this study, we aimed to decipher the receptor complex assembly in IL-2- and IL-15-activated T-lymphocytes that is highly orchestrated by site-specific phosphorylation events. Comparing the cytokine-induced interactome of the interleukin receptor beta and gamma subunits shared by the two cytokines, we defined the components of the early IL-2 and IL-15 receptor-associated complex discovering novel constituents. Additionally, phosphopeptide-directed analysis allowed us to detect several cytokine-dependent and -independent phosphorylation events within the activated receptor complex including novel phosphorylated sites located in the cytoplasmic region of IL-2 receptor β subunit (IL-2Rβ). We proved that the distinct phosphorylations induced by the cytokines serve for recruiting different types of effectors to the initial receptor/ligand complex. Overall, our study sheds new light into the initial molecular events triggered by IL-2 and IL-15 and constitutes a further step toward a better understanding of the early signaling aspects of the two closely related cytokines in T-lymphocytes.

  6. Tumour necrosis factor-alpha receptors are present in the corpus luteum throughout the oestrous cycle and during the early gestation period in pigs.

    Science.gov (United States)

    Miyamoto, Y; Sakumoto, R; Sakabe, Y; Miyake, M; Okano, A; Okuda, K

    2002-04-01

    To determine the physiological significance of tumour necrosis factor-alpha (TNFalpha) in the regulation of luteal functions in pig, this study was conducted to identify the presence of functional TNFalpha receptors in porcine corpora lutea (CL) throughout the oestrous cycle and the early gestation. The CL were isolated from pigs on days 4, 6, 8, 12 or 15 of the oestrous cycle (n=3; day 0 = oestrus) and days 15, 20 or 25 of gestation (n=3; day 0 = mating). A Scatchard analysis revealed the presence of a high-affinity binding site for TNFalpha in all samples (dissociation constant; 2.7 +/- 0.51 to 5.8 +/- 0.50 nM). The concentration of TNFalpha receptors was higher on day 15 of the oestrous cycle than on days 4 and 8 of the oestrous cycle (p gestation period. In addition, TNFalpha receptor concentration in the CL of the late luteal stage (day 15) of the oestrous cycle was higher than on the respective day in the early pregnant pig, suggesting that TNFalpha plays a role in accomplishing luteolysis in the porcine CL.

  7. Periodic behaviors

    CERN Document Server

    Napp, Diego; Shankar, Shiva

    2010-01-01

    This paper studies behaviors that are defined on a torus, or equivalently, behaviors defined in spaces of periodic functions, and establishes their basic properties analogous to classical results of Malgrange, Palamodov, Oberst et al. for behaviors on R^n. These properties - in particular the Nullstellensatz describing the Willems closure - are closely related to integral and rational points on affine algebraic varieties.

  8. PERIODIC BEHAVIORS

    NARCIS (Netherlands)

    Napp, Diego; Put, Marius van der; Shankar, Shiva

    2010-01-01

    This paper studies behaviors that are defined on a torus, or equivalently, behaviors defined in spaces of periodic functions, and establishes their basic properties analogous to classical results of Malgrange, Palamodov, Oberst et al. for behaviors on R(n). These properties-in particular the Nullste

  9. Exploring the interaction of personal and contextual factors during the induction period of science teachers and how this interaction shapes their enactment of science reform

    Science.gov (United States)

    Saka, Yavuz

    The first years of teaching are demanding as the novice works to gain a degree of familiarity in her/his professional work. It is during this period that many teachers decide to leave the teaching profession or move away from the reform-minded beliefs and practices acquired during their teacher preparation programs. To understand what happens during induction requires a focus on both the cognitive and contextual issues related to science teaching. The goal of this qualitative, multi-case study was to describe the induction experiences of two reform-minded first year science teachers and the strategies they used to negotiate contradictions embedded the context of schooling. Using the frame of Cultural Historical Activity Theory, in this research I focused on changes in science teachers' personal and professional identities, self-efficacy and pedagogical discontentment, the manner in which these factors shaped science teaching practices, and beliefs and practices shaped and were shaped by the context of the novices' work. Data included a year of participant observations, surveys, open-ended questionnaires, interviews, classroom observations, and mediating artifacts such as lesson plans and assignments. Identities and dispositions of these teachers played significant role their attempts to become competent members of their school communities, attempts that influenced and were influenced by their teaching self-efficacy and pedagogical discontentment. Mild contradictions in the system allowed for the refinement of reform-minded science teaching practices, while extreme contradictions in the system served to change one teacher's goals and prevented his successful enactment of science education reform. Findings indicated that the successful enactment of reform-minded practice depends not just on contextual factors related to schools, or just on individual factors associated with science teaching. Instead, personal and contextual factors interact to shape a novice's first

  10. Incidence of modifiable cardiovascular risk factors and treatment of persons suffering from diabetes in the Bjelovar-Bilogora County during the period from 2001 to 2012

    Directory of Open Access Journals (Sweden)

    Magas Sasa

    2013-07-01

    Full Text Available The aim of this article is to present the incidence of modifiable cardiovascular risk factors and types of applied diabetes therapy in outpatients in the Center for Diabetes in the Bjelovar-Bilogora County during the period from 2001 to 2012.The study involved 4,408 outpatients whose e-records are maintained by the national register of diabetic persons CroDiab NET. 93% of patients had type 2 diabetes, while type 1 diabetes was recorded in only 3% of patients. Hypertension was present in 51% of patients with an upward trend in the last three years. The highest rate of dyslipidemia was 39% in 2004, with a downward trend at about 25% in the last 3 years. The frequency of patients with myocardial infarction was stable at around 10%, with the lowest value of 7.4% in 2010. The prevalence of patients with stroke also showed a downward trend from 14.9% to 7.4%. Only 10% of patients had body mass index (BMI 30 kg/m2. Good disease control was achieved by only 18% of patients, a further 18% of them had borderline disease control. Less than 1% of patients were treated only by changes in lifestyle and diet, while 43% of them were treated by oral medications. The combination of oral medications with insulin was applied in 38% of patients, and only 15% of patients were treated by insulin.To conclude, the influx of patients in the Center for Diabetes of the Bjelovar-Bilogora County is rising. The values of BMI, Hba1c levels and the incidence of hypertension and dyslipidemia are worrisome. A decrease in Hba1c which is a result of pronounced insulinization, or the introduction of new drugs such as DPP 4 inhibitors and GLP 1 analogues is encouraging

  11. Molecular Characterization of Two Monoclonal Antibodies against the Same Epitope on B-Cell Receptor Associated Protein 31.

    Science.gov (United States)

    Kim, Won-Tae; Shin, Saemina; Hwang, Hyo Jeong; Kim, Min Kyu; Jung, Han-Sung; Park, Hwangseo; Ryu, Chun Jeih

    2016-01-01

    Previously, we showed that B-cell receptor associated protein 31 (BAP31), an endoplasmic reticulum (ER) membrane chaperone, is also expressed on the cell surface by two monoclonal antibodies (MAbs) 297-D4 and 144-A8. Both MAbs recognize the same linear epitope on the C-terminal domain of BAP31, although they were independently established. Here, flow cytometric analysis showed that 144-A8 had additional binding properties to some cells, as compared to 297-D4. Quantitative antigen binding assays also showed that 144-A8 had higher antigen binding capacity than 297-D4. Affinity measurement revealed that 144-A8 had 1.54-fold higher binding affinity than 297-D4. Analysis of the heavy- and light-chain variable region sequences of two MAbs revealed that both MAbs belonged to the same heavy chain (Igh-V3660 VH3) and light chain subgroup (IGKV21) with just two amino acid differences in each framework region, indicating that both MAbs arise from the same germline origin. Seven amino acid differences were found between the complementarity determining regions (CDRs) of the two MAbs. Molecular modeling of the epitope-paratope complexes revealed that the epitope appeared to reside in closer proximity to the CDRs of 144-A8 than to those of 297-D4 with the stronger hydrogen bond interactions with the former than the latter. More interestingly, an additional hydrophobic interaction appeared to be established between the leucine residue of epitope and the paratope of 144-A8, due to the substitution of H-Tyr101 for H-Phe101 in 144-A8. Thus, the different binding specificity and affinity of 144-A8 appeared to be due to the different hydrogen bonds and hydrophobic interaction induced by the alterations of amino acids in CDRs of 144-A8. The results provide molecular insights into how the binding specificities and affinities of antibodies evolve with the same epitope in different microenvironments.

  12. Mammalian 43-kD acetylcholine receptor-associated protein (RAPsyn) is expressed in some nonmuscle cells

    Energy Technology Data Exchange (ETDEWEB)

    Musil, L.S.; Frail, D.E.; Merlie, J.P. (Washington Univ. School of Medicine, St. Louis, MO (USA))

    1989-05-01

    Torpedo electric organ and vertebrate neuromuscular junctions contain the receptor-associated protein of the synapse (RAPsyn) (previously referred to as the 43K protein), a nonactin, 43,000-Mr peripheral membrane protein associated with the cytoplasmic face of postsynaptic membranes at areas of high nicotinic acetylcholine receptor (AChR) density. Although not directly demonstrated, several lines of evidence suggest that RAPsyn is involved in the synthesis and/or maintenance of such AChR clusters. Microscopic and biochemical studies had previously indicated that RAPsyn expression is restricted to differentiated, AChR-synthesizing cells. Our recent finding that RAPsyn is also produced in undifferentiated myocytes led to to examine whether RAPsyn is synthesized in cell types that never express AChR (i.e., cells of other than skeletal muscle origin). Various primary and established rodent cell lines were metabolically labeled with (35S)methionine, and extracts were immunoprecipitated with a monospecific anti-RAPsyn serum. Analysis of these immunoprecipitates by SDS-PAGE revealed detectable RAPsyn synthesis in some (notably fibroblast and Leydig tumor cell lines and primary cardiac cells) but not all (hepatocyte- and lymphocyte-derived) cell types. These results were further substantiated by peptide mapping studies of RAPsyn immunoprecipitated from different cells and quantitation of RAPsyn-encoding mRNA levels in mouse tissues. RAPsyn synthesized in both muscle and nonmuscle cells was shown to be tightly associated with membranes. These findings demonstrate that RAPsyn is not specific to skeletal muscle-derived cells and imply that it may function in a capacity either in addition to or instead of AChR clustering.

  13. Receptor-associated protein (RAP plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice.

    Directory of Open Access Journals (Sweden)

    Guilian Xu

    Full Text Available BACKGROUND: Receptor associated protein (RAP functions in the endoplasmic reticulum (ER to assist in the maturation of several membrane receptor proteins, including low density lipoprotein receptor-related protein (LRP and lipoprotein receptor 11 (SorLA/LR11. Previous studies in cell and mouse model systems have demonstrated that these proteins play roles in the metabolism of the amyloid precursor protein (APP, including processes involved in the generation, catabolism and deposition of beta-amyloid (Abeta peptides. METHODOLOGY/PRINCIPAL FINDINGS: Mice transgenic for mutant APPswe and mutant presenilin 1 (PS1dE9 were mated to mice with homozygous deletion of RAP. Unexpectedly, mice that were homozygous null for RAP and transgenic for APPswe/PS1dE9 showed high post-natal mortality, necessitating a shift in focus to examine the levels of amyloid deposition in APPswe/PS1dE9 that were hemizygous null for RAP. Immunoblot analysis confirmed 50% reductions in the levels of RAP with modest reductions in the levels of proteins dependent upon RAP for maturation [LRP trend towards a 20% reduction ; SorLA/LR11 statistically significant 15% reduction (p<0.05]. Changes in the levels of these proteins in the brains of [APPswe/PS1dE9](+/-/RAP(+/- mice correlated with 30-40% increases in amyloid deposition by 9 months of age. CONCLUSIONS/SIGNIFICANCE: Partial reductions in the ER chaperone RAP enhance amyloid deposition in the APPswe/PS1dE9 model of Alzheimer amyloidosis. Partial reductions in RAP also affect the maturation of LRP and SorLA/LR11, which are each involved in several different aspects of APP processing and Abeta catabolism. Together, these findings suggest a central role for RAP in Alzheimer amyloidogenesis.

  14. Receptor-associated protein blocks internalization and cytotoxicity of myeloma light chain in cultured human proximal tubular cells.

    Directory of Open Access Journals (Sweden)

    Sule Sengul

    Full Text Available BACKGROUND: Free light chains (LCs are among the many ligands that bind to cubilin/megalin for endocytosis via the clathrin-dependent endosomal/lysosomal pathway. Receptor associated protein (RAP, is a 39 kDA high-affinity, chaperone-like ligand for megalin that assists in the proper folding and functioning of megalin/cubilin. Although RAP is known to inhibit ligand binding to megalin/cubilin, its effect on LC endocytosis has not been shown directly. METHODS AND PRINCIPAL FINDINGS: We investigated whether RAP can block the endocytosis of LC in cultured human proximal tubule cells and whether this can prevent LC cytotoxicity. Immunofluorescence microscopy and flow cytometry showed that fluorescently labeled LC endocytosis was markedly inhibited in HK-2 cells pretreated with human RAP. The effect of RAP was dose-dependent, and was predominantly on endocytosis as it had no effect on the small acid-washable fraction of LC bound to cell membrane. RAP significantly inhibited LC induced cytokine production and phosphorylation of ERK1/2 and p38 MAPK. Prolonged exposure to LC for 48 h resulted in epithelial-to-mesenchymal transformation in HK-2 cells as evidenced by marked reduction in the expression of the epithelial cell marker E-cadherin, and increased the expression of the mesenchymal marker α-SMA, which was also prevented by RAP in the endocytosis medium. CONCLUSIONS: RAP inhibited LC endocytosis by ∼88% and ameliorated LC-induced cytokine responses and EMT in human PTCs. The results not only provide additional evidence that LCs endocytosis occurs via the megalin/cubilin endocytic receptor system, but also show that blocking LC endocytosis by RAP can protect proximal tubule cells from LC cytotoxicity.

  15. Receptor-associated protein (RAP) plays a central role in modulating Abeta deposition in APP/PS1 transgenic mice.

    Science.gov (United States)

    Xu, Guilian; Karch, Celeste; Li, Ning; Lin, Nianwei; Fromholt, David; Gonzales, Victoria; Borchelt, David R

    2008-09-08

    Receptor associated protein (RAP) functions in the endoplasmic reticulum (ER) to assist in the maturation of several membrane receptor proteins, including low density lipoprotein receptor-related protein (LRP) and lipoprotein receptor 11 (SorLA/LR11). Previous studies in cell and mouse model systems have demonstrated that these proteins play roles in the metabolism of the amyloid precursor protein (APP), including processes involved in the generation, catabolism and deposition of beta-amyloid (Abeta) peptides. Mice transgenic for mutant APPswe and mutant presenilin 1 (PS1dE9) were mated to mice with homozygous deletion of RAP. Unexpectedly, mice that were homozygous null for RAP and transgenic for APPswe/PS1dE9 showed high post-natal mortality, necessitating a shift in focus to examine the levels of amyloid deposition in APPswe/PS1dE9 that were hemizygous null for RAP. Immunoblot analysis confirmed 50% reductions in the levels of RAP with modest reductions in the levels of proteins dependent upon RAP for maturation [LRP trend towards a 20% reduction ; SorLA/LR11 statistically significant 15% reduction (pRAP(+/-) mice correlated with 30-40% increases in amyloid deposition by 9 months of age. Partial reductions in the ER chaperone RAP enhance amyloid deposition in the APPswe/PS1dE9 model of Alzheimer amyloidosis. Partial reductions in RAP also affect the maturation of LRP and SorLA/LR11, which are each involved in several different aspects of APP processing and Abeta catabolism. Together, these findings suggest a central role for RAP in Alzheimer amyloidogenesis.

  16. Structure-Function Similarities between a Plant Receptor-like Kinase and the Human Interleukin-1 Receptor-associated Kinase-4*

    OpenAIRE

    2011-01-01

    Phylogenetic analysis has previously shown that plant receptor-like kinases (RLKs) are monophyletic with respect to the kinase domain and share an evolutionary origin with the animal interleukin-1 receptor-associated kinase/Pelle-soluble kinases. The lysin motif domain-containing receptor-like kinase-3 (LYK3) of the legume Medicago truncatula shows 33% amino acid sequence identity with human IRAK-4 over the kinase domain. Using the structure of this animal kinase as a template, homology model...

  17. Factors related to changes in the quality of life among Polish adolescents and adults with cystic fibrosis over a 1-year period

    Directory of Open Access Journals (Sweden)

    Dębska G

    2015-12-01

    Full Text Available Grażyna Dębska,1 Henryk Mazurek2 1Faculty of Health and Medical Studies, Andrzej Frycz Modrzewski Krakow University, Krakow, 2Department of Pneumonology and Cystic Fibrosis, National Tuberculosis and Lung Diseases Research Institute, Rabka, Poland Background: The aim of this study was to determine the effects of clinical factors, physical activity, and sociodemographic variables on 1-year changes in health-related quality of life (HRQoL in Polish adolescents and adults with cystic fibrosis (CF.Method: The study included 67 subjects with CF (mean age 21.1±5.1 years; range 14–37 years; 34 males and 33 females. The Cystic Fibrosis Quality of Life Questionnaire was used at baseline and after 1 year. Lung function data, body weight, and body height were extracted from medical records. Clinical assessment was performed with the Shwachman–Kulczycki scale.Results: The highest scores in both HRQoL examinations came from the domains of physical and social functioning, and the lowest from future concerns, body image, and career concerns. No significant changes of Cystic Fibrosis Quality of Life Questionnaire scores were documented over a period of 1 year. Patients with better baseline spirometry results more frequently reported an improvement in the treatment issues (subjects with FEV1 >50% of predicted, P=0.020 and in the career concerns (patients with FVC >50% of predicted, P=0.039. The improvement in the career concerns also depended upon daily physical activity (P=0.024, which was shown to modulate future concerns (P=0.032, along with place of residence and living conditions (P=0.003. Moreover, the time elapsed from the last pulmonary exacerbation was related to the change in social functioning (P=0.026.Conclusion: When planning treatment, attention should be paid to interventions which may improve HRQoL. Systematic chronic therapy improves lung function, related to treatment issues and career concerns. Maintaining good physical condition and

  18. G-protein coupled receptor-associated sorting protein 1 (GASP-1), a potential biomarker in breast cancer.

    Science.gov (United States)

    Tuszynski, George P; Rothman, Vicki L; Zheng, Xiaoyi; Gutu, Mohammed; Zhang, Xinmin; Chang, Frank

    2011-10-01

    An innovative "2-D high performance liquid electrophoresis" (2-D HPLE) technology was used to identify serum biomarkers associated with the early stage of breast cancer in addition to other more advanced stages. 2-D HPLE is a newly developed electrophoretic technology that separates 100s of serum albumin complexes on a polyvinyl membrane based on their surface charges. Association of cancer proteins or their fragments (biomarkers) with pre-existing albumin complexes in the blood of cancer patients results in altered mobility on the membrane. Using 2-D HPLE we identified that a specific fragment of G-protein coupled receptor-associated sorting protein 1 (GASP-1) was present in the sera of patients with early stage disease but absent in sera of normal patients. GASP-1 has been shown to modulate lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors in neuronal cells. However, no reports have linked GASP-1 to breast cancer pathogenesis. GASP-1 was detected in tumor extracts of 7 cases of Stage 2 and Stage 3 breast cancers, but not in adjacent normal tissue as revealed by western blot analysis using an antibody developed against a GASP-1 peptide identified by our 2-D HPLE technology. Using this antibody, we immunohistochemically detected over-expression of GASP-1 in all of 107 cases of archived ductal breast carcinoma tumor samples, while normal adjacent breast tissue from 12 cases of ductal carcinoma showed little or no staining. Additionally, all 10 cases of metastatic breast carcinoma present in lymph nodes were positive. Strong positive GASP-1 staining was observed in all tumor tissue including ductal carcinoma in situ (DCIS) and invasive ductal carcinoma. Additionally, we observed a wide spectrum of enhanced staining of premalignant ductal epithelial cells present in benign ducts and those found in atypical ductal hyperplasia (ADH). These studies identify GASP-1 as a potential new serum and tumor biomarker for breast cancer

  19. Phylogenetic and functional analyses of a plant protein related to human B-cell receptor-associated proteins.

    Science.gov (United States)

    Atabekova, Anastasia K; Pankratenko, Anna V; Makarova, Svetlana S; Lazareva, Ekaterina A; Owens, Robert A; Solovyev, Andrey G; Morozov, Sergey Y

    2017-01-01

    Human B-cell receptor-associated protein BAP31 (HsBAP31) is the endoplasmic reticulum-resident protein involved in protein sorting and transport as well as pro-apoptotic signaling. Plant orthologs of HsBAP31 termed 'plant BAP-like proteins' (PBL proteins) have thus far remained unstudied. Recently, the PBL protein from Nicotiana tabacum (NtPBL) was identified as an interactor of Nt-4/1, a plant protein known to interact with plant virus movement proteins and affect the long-distance transport of potato spindle tuber viroid (PSTVd) via the phloem. Here, we have compared the sequences of PBL proteins and studied the biochemical properties of NtPBL. Analysis of a number of fully sequenced plant genomes revealed that PBL-encoding genes represent a small multigene family with up to six members per genome. Two conserved motifs were identified in the C-terminal region of PBL proteins. The NtPBL C-terminal hydrophilic region (NtPBL-C) was expressed in bacterial cells, purified, and used for analysis of its RNA binding properties in vitro. In gel shift experiments, NtPBL-C was found to bind several tested RNAs, showing the most efficient binding to microRNA precursors (pre-miRNA) and less efficient interaction with PSTVd. Mutational analysis suggested that NtPBL-C has a composite RNA-binding site, with two conserved lysine residues in the most C-terminal protein region being involved in binding of pre-miRNA but not PSTVd RNA. Virus-mediated transient expression of NtPBL-C in plants resulted in stunting and leaf malformation, developmental abnormalities similar to those described previously for blockage of miRNA biogenesis/function. We hypothesize that the NtPBL protein represents a previously undiscovered component of the miRNA pathway. Copyright © 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  20. Advanced survival models for risk-factor analysis in scrapie. : PrP genotype influence on scrapie infection risk and incubation period.

    OpenAIRE

    Corbière, Fabien; Barillet, Francis; Andréoletti, Olivier; Fidelle, Francis; Laphitz-Bordet, Nathalie; Schelcher, François; Joly, Pierre

    2007-01-01

    International audience; Because of the confounding effects of long incubation duration and flock management, accurate epidemiological studies of scrapie outbreaks are difficult to carry out. In this study, 641 Manech red-faced sheep from six scrapie-affected field flocks in Pyr?es Atlantiques, France, were monitored for clinical scrapie over a 6-9 year period. Over this period, 170 scrapie clinical cases were recorded and half of the culled animals were submitted for post-mortem transmissible...

  1. Phenomenon of the inner psychological migration as the factor of the national identity preservation in a period of social crises, anomia and repressions in case of the Polish settlement Marchlewsk (Dovbysh

    Directory of Open Access Journals (Sweden)

    Staniszewska Żanna

    2016-04-01

    Full Text Available The article gives a review of the population history of the Polish National Region named after Julian Marchlewski (settlement of Dovbysh, Zhitomir province, Ukraine. The author explores the psychological factors affecting the preservation of culture, religion and identity of the Polish community in the period of the repressions 1920-30 years. The article researches and analyses the phenomenon of internal psychological migration as a factor in preservation of national and personal self-identity.

  2. A Search for Factors Causing Training Costs to Rise by Examining the U. S. Navy’s AT, AW, and AX Ratings during their First Enlistment Period

    Science.gov (United States)

    1986-09-01

    if we use the entire time period spanned by the data base, year group 7S will have had more time to aquire NEC codes than year group SO. Wc need to...the SAS programning, language . SAS provided us numerical computation, statistical results, and graphical summaries. SAS programs used by this study are

  3. Factores psicosociales asociados a un alto, medio y bajo riesgo de síntomas depresivos en el posparto inmediato Psychosocial factors associated to low, medium and high risk of depressive symptoms in the immediate postpartum period

    Directory of Open Access Journals (Sweden)

    Cynthia Inés Paolini

    2012-03-01

    Full Text Available OBJETIVOS: evaluar factores psicosociales asociados a síntomas depresivos en el posparto inmediato. MÉTODOS: 45 mujeres puérperas de un hospital público de Buenos Aires, Argentina, fueron entrevistadas entre el 1er y el 3er día posparto, de marzo-diciembre 2010. La Escala de Depresión Posnatal de Edimburgo (EPDS fue administrada para evaluar síntomas depresivos. La entrevista psicológica perinatal (EPP fue administrada para detectar variables psicosociales. A partir de los resultados obtenidos en la EPDS, se separó la muestra en tres grupos con diferentes grados de riesgo de sintomatología depresiva: "negativas o de bajo riesgo", "positivas de riesgo medio" y "positivas de alto riesgo". Los puntajes de corte utilizados fueron 9 y 19. RESULTADOS: se encontraron diferencias significativas entre los tres grupos con violencia familiar, migración, historia previa de depresión, presencia de síntomas depresivos durante el embarazo y mayor cantidad de estresores. CONCLUSIONES: el establecimiento de los dos puntajes de corte en la EPDS permite una detección temprana de las mujeres que presentan síntomas depresivos. Se sugiere la utilidad del puntaje de corte de 19 para la detección temprana de mujeres con mayor riesgo de desarrollar depresión posparto.OBJECTIVES: evaluate psychosocial factors associated to depressive symptoms during the immediate postpartum period. METHODS: a total of 45 argentine puerperal women hospitalized in a public maternal hospital of Buenos Aires, Argentina, were interviewed on the 1st and 3rd day postpartum from March to December 2010. Aiming to assess the presence of depressive symptoms, the Edinburgh Postnatal Depression Scale (EPDS was administrated. The Perinatal Psychological Interview was administrated to explore psychosocial variables. Based on the scores obtained in the EPDS, the sample was separated in three different groups with increasing risk of depressive symptomatology: "negative or low risk

  4. La percepción de los factores de influencia por los periodistas dentro de la cultura periodística de España

    Directory of Open Access Journals (Sweden)

    Martin Oller Alonso

    2012-12-01

    Full Text Available In this article we analyze journalists perceptions of the influence factors within the journalistic culture of Spain. In order to reach a greater understanding of the professional context we use the concept of journalistic culture that is based on the thin line between national cultures and the universal concept of culture as a way of life. Our empirical study is based on the international quantitative project Worlds of Journalism (WoJ, directed by Hanitzsch (2009. The objective is to determine the perception of the influence of contextual factors. The results show that Spanish journalists perceive the influences of the factors closest to them more intensively. As our analysis shows, Spanish journalistic culture portrays a greater interference of these factors within the routine of news professionals.

  5. Low Intensity Laser Irradiation and Growth Factors Influence Differentiation of Adipose Derived Stem Cells into Smooth Muscle Cells in a Coculture Environment over a Period of 72 Hours

    Directory of Open Access Journals (Sweden)

    Bernard Mvula

    2014-01-01

    Full Text Available Stem cells have the ability to self-renew and differentiate into several specialised cells. Low intensity laser irradiation (LILI has been shown to have positive effects on cells including adipose derived stem cells (ADSCs. Growth factors such as retinoic acid and transforming growth factor (TGF-β1 play significant roles in the differentiation of cells. This study aimed at investigating the role of LILI and growth factors on differentiation of adipose derived stem cells cocultured with smooth muscle cells (SMCs. The study used isolated human adipose derived stem cells and smooth muscle commercial cells (SKUT-1. The cells were cocultured directly in the ratio 1 : 1 using the established methods with and without growth factors (retinoic acid and TGF-β1 and then exposed to LILI at a wavelength of 636 nm with 5 J/cm2 using a diode laser. The cellular proliferation and expression of the both cell type markers were assessed using optical density and flow cytometry at 24 h and 72 h. The study showed that LILI increased the proliferation of cocultured cells. The expression of the smooth muscle cell markers increased in the coculture groups that were exposed to LILI in the presence of growth factors while those of the ADSCs decreased.

  6. Periods of child growth up to age 8 years in Ethiopia, India, Peru and Vietnam: key distal household and community factors.

    Science.gov (United States)

    Schott, Whitney B; Crookston, Benjamin T; Lundeen, Elizabeth A; Stein, Aryeh D; Behrman, Jere R

    2013-11-01

    Recent research has demonstrated some growth recovery among children stunted in infancy. Less is known about key age ranges for such growth recovery, and what factors are correlates with this growth. This study characterized child growth up to age 1 year, and from ages 1 to 5 and 5 to 8 years controlling for initial height-for-age z-score (HAZ), and identified key distal household and community factors associated with these growth measures using longitudinal data on 7266 children in the Young Lives (YL) study in Ethiopia, India, Peru and Vietnam. HAZ at about age 1 year and age in months predicted much of the variation in HAZ at age 5 years, but 40-71% was not predicted. Similarly, HAZ at age 5 years and age in months did not predict 26-47% of variation in HAZ at 8 years. Multiple regression analysis suggests that parental schooling, consumption, and mothers' height are key correlates of HAZ at about age 1 and also are associated with unpredicted change in HAZ from ages 1 to 5 and 5 to 8 years, given initial HAZ. These results underline the importance of a child's starting point in infancy in determining his or her growth, point to key distal household and community factors that may determine early growth in early life and subsequent growth recovery and growth failure, and indicate that these factors vary some by country, urban/rural designation, and child sex.

  7. Isolated limb perfusion with tumor necrosis factor alpha and melphalan for locally advanced soft tissue sarcoma : Three time periods at risk for amputation

    NARCIS (Netherlands)

    van Ginkel, Robert J.; Thijssens, Katja M. J.; Pras, Elisabeth; Van der Graaf, Winette T. A.; Suurmeijer, Albert J. H.; Hoekstra, Harald J.

    2007-01-01

    Background: The aim of this study was to investigate the long-term limb salvage rate and overall survival after isolated limb perfusion (ILP) with tumor necrosis factor alpha and melphalan for locally advanced soft tissue sarcoma (STS). Methods: From 1991 to 2003, 73 patients (36 men, 37 women, medi

  8. Risk factors associated with trajectories of mothers' depressive symptoms across the early parenting period: an Australian population-based longitudinal study.

    Science.gov (United States)

    Giallo, Rebecca; Cooklin, Amanda; Nicholson, Jan M

    2014-04-01

    Approximately 14 % of women experience depressive symptoms in the first postnatal year. Few studies have examined the persistence of symptoms beyond this time. This study aims to (a) assess the course of women's depressive symptoms from the first postnatal year to when their children were aged 6-7 years, (b) identify distinct groups of women defined by their symptom trajectories over time, and (c) identify antenatal and early postnatal risk factors associated with persistent symptoms. Data from 4,879 women participating in the Longitudinal Study of Australian Children were analysed using latent growth modelling and logistic regression to identify risk factors associated with class membership. For the overall sample, depressive symptoms were highest during the first postnatal year and then gradually decreased over 6-7 years. Two distinct classes were identified with the majority of women (84 %) reporting minimal symptoms over time, and 16 % experiencing persistently high symptoms. Risk factors were younger maternal age, being from a non-English speaking background, not completing high school, having a past history of depression, antidepressant use during pregnancy, child development problems, lower parenting self-efficacy, poor relationship quality, and stressful life events. This research identifies risk factors that may predispose mothers to enduring depressive symptoms, offering opportunities for early identification and targeted early intervention.

  9. 民族地区集市交易行为的非经济因素分析——以湘西墟场集市为例%An Analysis on Non-economic Factors of Trading Behavior in Periodic Market of Minority Areas --Example for Periodic Market of Xiangxi Minority Areas

    Institute of Scientific and Technical Information of China (English)

    李子娟; 李陈华; 冷志明

    2012-01-01

    As the primary market of the minority areas market system, periodic market plays an important role in people's daily production and living. This paper aims to further analyze the market problem in minority areas from a new perspective of non- economic factors based on the case study of Xiangxi minority periodic market, with the periodic market trading behaviors as the research staring point. The research indicates that minority's ethics, culture and customs as well as the ideology are the main influencing factors towards the periodic market operation.%集市作为民族地区市场体系中的基层市场,在人们日常的生产和生活中发挥着重要的作用。笔者以湘西民族地区墟场集市为研究案例,以集市交易行为为研究起点,以非经济因素这一新颖性的角度来进一步研究民族地区市场问题。研究认为民族地区集市的运行更多的受到少数民族的伦理道德、文化习俗以及意识形态等非经济因素的影响。

  10. The effect of repeated administrations of llama ovulation-inducing factor (OIF/NGF) during the peri-ovulatory period on corpus luteum development and function in llamas.

    Science.gov (United States)

    Fernández, A; Ulloa-Leal, C; Silva, M; Norambuena, C; Adams, G P; Guerra, M; Ratto, M H

    2014-10-01

    The objective of the study was to test the hypothesis that repeated administrations of OIF/NGF during the peri-ovulatory period (pre-ovulatory, ovulatory, early post-ovulatory), will enhance the luteotrophic effect in llamas. Female llamas were examined daily by transrectal ultrasonography in B- and Doppler-mode using a scanner equipped with a 7.5-MHz linear-array transducer to monitor ovarian follicle and luteal dynamics. When a growing follicle ≥7mm was detected, llamas were assigned randomly to one of the three groups and given 1mg of purified OIF/NGF im (intramuscular) (a) pre-ovulation (single dose; n=12), (b) pre-ovulation and at the time of ovulation (2 doses, n=10), or (c) pre-ovulation, at the time of ovulation, and 24h after ovulation (3 doses, n=10). The pre-ovulatory follicle diameter at the time of treatment, ovulation rate and the first day of CL detection did not differ (P=0.3) among groups. However, maximum CL diameter was greatest (P=0.003) in llamas in the 2-dose group, and smallest in the 3-dose group. Accordingly, the 2 dose-group had the largest day-to-day profile for CL diameter (Pllama seminal plasma is luteotrophic and the effect on CL size and function is affected by the number and timing of treatments during the peri-ovulatory period.

  11. Periodic Ising Correlations

    CERN Document Server

    Hystad, Grethe

    2010-01-01

    In this paper, we first rework B. Kaufman's 1949 paper, "Crystal Statistics. II. Partition Function Evaluated by Spinor Analysis", by using representation theory. Our approach leads to a simpler and more direct way of deriving the spectrum of the transfer matrix for the finite periodic Ising model. We then determine formulas for the spin correlation functions that depend on the matrix elements of the induced rotation associated with the spin operator in a basis of eigenvectors for the transfer matrix. The representation of the spin matrix elements is obtained by considering the spin operator as an intertwining map. We exhibit the "new" elements V+ and V- in the Bugrij-Lisovyy formula as part of a holomorphic factorization of the periodic and anti-periodic summability kernels on the spectral curve associated with the induced rotation for the transfer matrix.

  12. [FACTORS AFFECTING THE ABANDONMENT OF BREASTFEEDING IN A SUPPORT PROGRAM FOR THE SAME IN THE HOSPITAL FOR WOMEN, MORELIA MICHOACAN IN THE PERIOD FROM SEPTEMBER TO NOVEMBER 2014].

    Science.gov (United States)

    Méndez Jacobo, Névedy; García Rojas Vazquez, Luisa Estefanía; Reyes Barretero, Diana Yolanda; Trujano Ramos, Luis Alfredo

    2015-12-01

    Introducción: existen ciertos factores que influyen en el abandono precoz de la lactancia materna, entre los cuales se encuentran los sociodemográficos, culturales, biológicos y psicológicos. Objetivo: analizar los factores sociodemográficos que influyen en el abandono de la lactancia materna en un grupo de apoyo a la misma. Metodología: estudio descriptivo, prospectivo, observacional y transversal, en el Hospital de La Mujer en Morelia, Michoacán, de septiembre a noviembre del 2014, con un total de 86 mujeres en periodo de puerperio de la planta de ginecología. Resultados: las causas por las cuales se abandona la LME son: edad menor de 25 años (19.1%), localidad urbana (16.9%), estado civil unión libre (15.7%) y por el trabajo (9%). Conclusiones: en la mayor parte de las mujeres la edad, el nivel educativo y la localidad son los principales factores que influyen en cuanto al abandono de la lactancia materna antes del tiempo recomendado.

  13. Correlation between risk factors during the neonatal period and appearance of retinopathy of prematurity in preterm infants in neonatal intensive care units in Alexandria, Egypt

    Directory of Open Access Journals (Sweden)

    Abdel Hadi AM

    2013-05-01

    Full Text Available Ahmed Mahmoud Abdel Hadi, Islam Shereen HamdyDepartment of Ophthalmology, Alexandria University Hospital, Alexandria, EgyptBackground: This study aimed to identify the main risk factors for development of retinopathy of prematurity (ROP in neonatal intensive care units in Alexandria, Egypt, from January 2010 to January 2012.Methods: A prospective cohort study was undertaken in infants weighing < 1250 g and maternal postmenstrual age < 32 weeks if there was concern about prolonged exposure to oxygen. The main clinical outcomes were occurrence of any stage of ROP and in particular severe ROP. Perinatal variables considered were: birth weight, gestational age, gender, method of ventilation (nasal continuous airway pressure or intermittent mechanical ventilation, packed red blood cell and/or plasma transfusion, occurrence of sepsis, neonatal indirect hyperbilirubinemia, intraventricular hemorrhage, and patent ductus arteriosus. After obtaining informed consent from the parents, infants at risk were examined for ROP using indirect ophthalmoscopy, ie, RetCam II fundus photography.Results: The study included 152 infants of mean gestational age 31.02 weeks and mean birth weight 1.229 kg. Seventy-two cases (47.5% were male and 80 cases (52.5% were female. Of the cases screened, 100 (65.6% had no ROP, 52 had ROP of any stage (34.4%, and 27 (18% had stage 1, five (3.3% had stage 2, 17 (11.5% had stage 3, and three (1.6% had stage 4 disease. No infants had stage 5 ROP. Of all our cases with ROP, 15 (28.6% had prethreshold disease type 1 that required treatment, comprising 9.8% of all cases screened for ROP. Using stepwise logistic regression analysis, all risk factors studied were found to be significantly associated with the development of ROP, except for neonatal indirect hyperbilirubinemia. Severity of ROP was inversely proportional to birth weight and gestational age.Conclusion: ROP occurred in 34.4% of all infants screened in the neonatal intensive

  14. Persistence of uropathogenic Escherichia coli strains in the host for long periods of time: relationship between phylogenetic groups and virulence factors.

    Science.gov (United States)

    Narciso, A; Nunes, F; Amores, T; Lito, L; Melo-Cristino, J; Duarte, A

    2012-06-01

    Escherichia coli cause the majority of urinary tract infections (UTIs). Virulence plays an important role in the initial stages of interaction with the host, facilitating colonization of the urinary tract tissue. The purpose of this study was to assess whether there is a relationship between virulence and antibiotic resistance in the persistence of uropathogenic E. coli strains. This study included five patients with UTI between 2001 and 2009. The antibiotic resistance phenotype of 29 E. coli isolates was determined by the disk diffusion method. Clonal relationship was determined through M13 polymerase chain reaction (PCR) fingerprinting. Phylogeny, virulence factors, β-lactamases, and replicon typing were studied through PCR. Antibiogram profiles were found from different patients and corresponded to CTX-M-2, CTX-M-15, CTX-M-32, and TEM-52 enzymes. Plasmids belonged essentially to incompatibility group IncF. No clonal relationship was observed among isolates from different patients, except for patients 4 and 5. Phylogenetic group A was predominant. Our work showed that commensal group A possesses the same virulence factors as the pathogenic groups B1 and D. E. coli common pilus and type 1 fimbriae could play an important role in the persistence in the host and in symptomatic UTI, respectively, which, combined with extended-spectrum β-lactamases (ESBLs), are a cause of the dissemination of microorganisms in the hospital and the community.

  15. Impact of socioeconomic and meteorological factors on reservoirs' air quality: a case in the Three Gorges Reservoir of Chongqing (TGRC), China over a 10-year period.

    Science.gov (United States)

    Peng, Ying; Zhou, Fengwu; Cui, Jian; Du, Ke; Leng, Qiangmei; Yang, Fumo; Chan, Andy; Zhao, Hongting

    2017-07-01

    The Three Gorges Dam's construction and industrial transfer have resulted in a new air pollution pattern with the potential to threaten the reservoir eco-environment. To assess the impact of socioeconomic factors on the pattern of air quality vairation and economical risks, concentrations of SO2, NO2, and PM10, industry genres, and meteorological conditions were selected in the Three Gorges Reservoir of Chongqing (TGRC) during 2006-2015. Results showed that air quality had improved to some extent, but atmospheric NO2 showed an increased trend during 2011-2015. Spatially, higher atmospheric NO2 extended to the surrounding area. The primary industry, especially for agriculture, had shown to be responsible for the remarkable increase of atmospheric NO2 (p air pollutant reductions, but construction industries had inhibited the improvement of regional air quality. In the tertiary industry, the cargo industry at ports had significantly decreased atmospheric NO2 as a result of eliminating the obsoleted small ships. Contrarily, the highway transportation had brought more air pollutants. The relative humidity was shown to be the main meteorological factor, which had an extremely remarkable relation with atmospheric SO2 (p air quality improvement difficult, and atmospheric SO2, NO2, and PM10 deposition would aggravate regional soil and water acidification and reactivate heavy metal in soil and sediment, further to pose a high level of ecological risk in the TGRC and other countries with reservoirs in the world.

  16. Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission.

    LENUS (Irish Health Repository)

    Rebolledo, J

    2013-11-11

    SUMMARY Influenza causes significant morbidity and mortality in children. This study\\'s objectives were to describe influenza A(H1N1)pdm09 during the pandemic, to compare it with circulating influenza in 2010\\/2011, and to identify risk factors for severe influenza defined as requiring admission to a paediatric intensive care unit (PICU). Children hospitalized with influenza during the pandemic were older, and more likely to have received antiviral therapy than children hospitalized during the 2010\\/2011 season. In 2010\\/2011, only one child admitted to a PICU with underlying medical conditions had been vaccinated. The risk of severe illness in the pandemic was higher in females and those with underlying conditions. In 2010\\/2011, infection with influenza A(H1N1)pdm09 compared to other influenza viruses was a significant risk factor for severe disease. An incremental relationship was found between the number of underlying conditions and PICU admission. These findings highlight the importance of improving low vaccination uptake and increasing the use of antivirals in vulnerable children.

  17. Population structure, condition factor and reproductive period of Astyanax paranae (Eigenmann, 1914 (Osteichthyes: Characidae in a small and old Brazilian Reservoir

    Directory of Open Access Journals (Sweden)

    Milza Celi Fedatto Abelha

    2008-06-01

    Full Text Available The population structure, condition and reproductive period of Astyanax paranae adult individuals inhabiting a small reservoir were investigated. The fishes were quarterly captured from the riverine and lacustrine zones of the Alagados Reservoir, Paraná, Brazil, during 1996/1997 and 1998/1999. The sex ratio differed from 1:1 with the predominance of the females in all standard length classes and total population sample. The females showed higher condition than the males. Both the sexes presented lower mean condition values in April and higher mean condition values in July. The estimated values of the regression coefficient indicated isometric growth for the females and males. The gonadosomatic relationship reached a maximum value of 14.80% for the females and 8.43% for the males. The reproductive period possibly occurred from October to April.Foram investigados a estrutura populacional, condição e período reprodutivo de indivíduos adultos de Astyanax paranae habitantes de um pequeno reservatório. Os peixes foram capturados trimestralmente nas zonas fluvial e lacustre do reservatório de Alagados, Paraná, Brasil, durante 1996/1997 e 1998/1999. A proporção sexual diferiu de 1:1, com predomínio de fêmeas em todas as classes de tamanho padrão e na amostragem total da população. As fêmeas apresentaram melhor condição que os machos. Menores valores médios de condição ocorreram em abril e os maiores em julho, tanto para fêmeas quanto para machos. Os valores estimados do coeficiente de regressão linear indicaram crescimento isométrico para ambos os sexos. A relação gonadossomática alcançou o valor máximo de 14,80% para fêmeas e 8,43% para machos. O período reprodutivo da espécie possivelmente, se estendeu de outubro a abril.

  18. Factors affecting the thermal environment of Agassiz’s Desert Tortoise (Gopherus agassizii) cover sites in the Central Mojave Desert during periods of temperature extremes

    Science.gov (United States)

    Mack, Jeremy S.; Berry, Kristin H.; Miller, David; Carlson, Andrea S.

    2015-01-01

    Agassiz's Desert Tortoises (Gopherus agassizii) spend >95% of their lives underground in cover sites that serve as thermal buffers from temperatures, which can fluctuate >40°C on a daily and seasonal basis. We monitored temperatures at 30 active tortoise cover sites within the Soda Mountains, San Bernardino County, California, from February 2004 to September 2006. Cover sites varied in type and structural characteristics, including opening height and width, soil cover depth over the opening, aspect, tunnel length, and surficial geology. We focused our analyses on periods of extreme temperature: in summer, between July 1 and September 1, and winter, between November 1 and February 15. With the use of multivariate regression tree analyses, we found cover-site temperatures were influenced largely by tunnel length and subsequently opening width and soil cover. Linear regression models further showed that increasing tunnel length increased temperature stability and dampened seasonal temperature extremes. Climate change models predict increased warming for southwestern North America. Cover sites that buffer temperature extremes and fluctuations will become increasingly important for survival of tortoises. In planning future translocation projects and conservation efforts, decision makers should consider habitats with terrain and underlying substrate that sustain cover sites with long tunnels and expanded openings for tortoises living under temperature extremes similar to those described here or as projected in the future.

  19. The Oligomeric Outer Dynein Arm Assembly Factor CCDC103 Is Tightly Integrated within the Ciliary Axoneme and Exhibits Periodic Binding to Microtubules*

    Science.gov (United States)

    King, Stephen M.; Patel-King, Ramila S.

    2015-01-01

    CCDC103 is an ∼29-kDa protein consisting of a central RPAP3_C domain flanked by N- and C-terminal coiled coils. Defects in CCDC103 lead to primary ciliary dyskinesia caused by the loss of outer dynein arms. This protein is present along the entire length of the ciliary axoneme and does not require other dynein or docking complex components for its integration. Unlike other known dynein assembly factors within the axoneme, CCDC103 is not solubilized by 0.6 m NaCl and requires more chaotropic conditions, such as 0.5 m KI. Alternatively, it can be extracted using 0.3% sarkosyl. CCDC103 forms stable dimers and other oligomers in solution through interactions involving the central domain. The smallest particle observed by dynamic light scattering has a hydrodynamic diameter of ∼25 nm. Furthermore, CCDC103 binds microtubules directly, forming ∼9-nm diameter particles that exhibit a 12-nm spacing on the microtubule lattice, suggesting that there may be two CCDC103 units per outer arm dynein repeat. Although the outer dynein arm docking complex is necessary to form arrays of dyneins along microtubules, it is not sufficient to set up a single array in a precise location on each axonemal doublet. We propose that CCDC103 helps generate a high-affinity site on the doublets for outer arm assembly, either through direct interactions or indirectly, perhaps by modifying the underlying microtubule lattice. PMID:25572396

  20. TNF receptor-associated factor-2 binding site is involved in TNFR75-dependent enhancement of TNFR55-induced cell death

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    TNF recepter-55 is the main mediator of TNF-induced apoptosis. TNF receptor-75-dependent induction or enhancement of cytotoxicity has been explained by intracellular signaling, “ligand passing”, or induction of endogenous TNF. To study the function of human TNF receptor-75 (hTR75) and the interaction between human TNF receptor-55 (hTR55) and hTR75 in hTNFc-induced cytotoxicity, Hep-2 cells were transfected with bicistronic expression vector of hTR75 and its deletion mutants genes. hTNFα-induced cytotoxicity was determined by crystal violet colorimetric method. The expression of hTR75 and its deletion mutants in Hep-2 cells was demonstrated by RT-PCR and indirect ELISA. We found that the overexpressed hTR75 could significantly increase the susceptibility of Hep-2 cells to hTNFα which especiαlly required TRAF2 binding site. hTR75 could not only mediate partial hTNFα-induced cytotoxicity independently but also fulfill an accessory role in enhancing or synergizing hTR55-mediated cytotoxicity.

  1. Extracellular collagenases and the endocytic receptor, urokinase plasminogen activator receptor-associated protein/Endo180, cooperate in fibroblast-mediated collagen degradation

    DEFF Research Database (Denmark)

    Madsen, Daniel H; Engelholm, Lars H; Ingvarsen, Signe

    2007-01-01

    The collagens of the extracellular matrix are the most abundant structural proteins in the mammalian body. In tissue remodeling and in the invasive growth of malignant tumors, collagens constitute an important barrier, and consequently, the turnover of collagen is a rate-limiting process...... in these events. A recently discovered turnover route with importance for tumor growth involves intracellular collagen degradation and is governed by the collagen receptor, urokinase plasminogen activator receptor-associated protein (uPARAP or Endo180). The interplay between this mechanism and extracellular...... collagenolysis is not known. In this report, we demonstrate the existence of a new, composite collagen breakdown pathway. Thus, fibroblast-mediated collagen degradation proceeds preferentially as a sequential mechanism in which extracellular collagenolysis is followed by uPARAP/Endo180-mediated endocytosis...

  2. Stimulation of receptor-associated kinase, tyrosine kinase, and MAP kinase is required for prolactin-mediated macromolecular biosynthesis and mitogenesis in Nb2 lymphoma.

    Science.gov (United States)

    Carey, G B; Liberti, J P

    1995-01-10

    Lactogens [prolactin (Prl) and growth hormone] stimulate phosphorylation of the 40S ribosomal protein, S6, in Nb2 cells by mechanisms that do not involve participation of cAMP or protein kinase A, protein kinase C, or cGMP-dependent protein kinase. However, inhibition of tyrosine kinase (TK) abrogates Prl-mediated macromolecular biosynthesis. Inasmuch as lactogen signaling may involve sequential activation of protein kinases, the effect of Prl on the well-characterized mitogen-activated protein kinase (MAPK) and S6 kinase (S6K), the enzyme responsible for S6 phosphorylation in vivo, and their relationship to Nb2 macromolecular biosynthesis and mitogenesis were investigated. The results show that MAPK stimulation is transient (peak activity, 30 min) and precedes that of S6K, which reaches a maximum at 1.5-2 h, and slowly returns towards control levels at 6 h. Both staurosporine which inhibits GH receptor-associated kinase (JAK2) and genistein (GEN), an inhibitor of membrane-associated and cytoplasmic TKs, abrogate Prl-stimulated TK, MAPK, and S6K. Rapamycin (RAP), a specific inhibitor of p70S6K, completely blocks S6K but does not affect TK and MAPK. TK and MAPK activity correlates with Prl-stimulated anabolism, i.e., protein and DNA synthesis and mitogenesis. Thus, concentrations of STR and GEN which abrogate TK and MAPK inhibit anabolism virtually 100%. However, RAP, which inhibits S6K (ca. 100%) but not TK or MAPK, only delays Prl-mediated anabolism. These results indicate that Prl signaling in Nb2 cells involves a protein kinase cascade and that regulation of receptor-associated kinase, TK, and MAPK correlates with anabolism. The role of S6K (and S6 phosphorylation) appears to be ancillary.

  3. The postanesthetic period. Complications.

    Science.gov (United States)

    Malamed, S F

    1987-01-01

    Postanesthetic complications can occur even in the best of circumstances. Proper preparation of the staff, aggressive monitoring of the recovering patient, and early recognition and management of the complications are essential if the outcome is to be successful. In reviewing postanesthetic complications, two factors are present in the overwhelming majority of situations--hypoxia and hypercarbia--often the direct result of inadequate monitoring during the postanesthetic period. The anesthetic procedure is not over once the anesthetic agents are discontinued. The skillful anesthetist is aware of the possibilities of postoperative complications and prevents problems by employing enhanced monitoring techniques during the recovery phase.

  4. Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry.

    Science.gov (United States)

    Demirkaya, Erkan; Saglam, Celal; Turker, Turker; Koné-Paut, Isabelle; Woo, Pat; Doglio, Matteo; Amaryan, Gayane; Frenkel, Joost; Uziel, Yosef; Insalaco, Antonella; Cantarini, Luca; Hofer, Michael; Boiu, Sorina; Duzova, Ali; Modesto, Consuelo; Bryant, Annette; Rigante, Donato; Papadopoulou-Alataki, Efimia; Guillaume-Czitrom, Severine; Kuemmerle-Deschner, Jasmine; Neven, Bénédicte; Lachmann, Helen; Martini, Alberto; Ruperto, Nicolino; Gattorno, Marco; Ozen, Seza

    2016-01-01

    Our aims were to validate the pediatric diagnostic criteria in a large international registry and to compare them with the performance of previous criteria for the diagnosis of familial Mediterranean fever (FMF). Pediatric patients with FMF from the Eurofever registry were used for the validation of the existing criteria. The other periodic fevers served as controls: mevalonate kinase deficiency (MKD), tumor necrosis factor receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS), aphthous stomatitis, pharyngitis, adenitis syndrome (PFAPA), and undefined periodic fever from the same registry. The performances of Tel Hashomer, Livneh, and the Yalcinkaya-Ozen criteria were assessed. The FMF group included 339 patients. The control group consisted of 377 patients (53 TRAPS, 45 MKD, 32 CAPS, 160 PFAPA, 87 undefined periodic fevers). Patients with FMF were correctly diagnosed using the Yalcinkaya-Ozen criteria with a sensitivity rate of 87.4% and a specificity rate of 40.7%. On the other hand, Tel Hashomer and Livneh criteria displayed a sensitivity of 45.0 and 77.3%, respectively. Both of the latter criteria displayed a better specificity than the Yalcinkaya-Ozen criteria: 97.2 and 41.1% for the Tel Hashomer and Livneh criteria, respectively. The overall accuracy for the Yalcinkaya-Ozen criteria was 65 and 69.6% (using 2 and 3 criteria), respectively. Ethnicity and residence had no effect on the performance of the Yalcinkaya-Ozen criteria. The Yalcinkaya-Ozen criteria yielded a better sensitivity than the other criteria in this international cohort of patients and thus can be used as a tool for FMF diagnosis in pediatric patients from either the European or eastern Mediterranean region. However, the specificity was lower than the previously suggested adult criteria.

  5. The use of a chronic disease and risk factor surveillance system to determine the age, period and cohort effects on the prevalence of obesity and diabetes in South Australian adults--2003-2013.

    Directory of Open Access Journals (Sweden)

    Anne W Taylor

    Full Text Available Age, period and cohort (APC analyses, using representative, population-based descriptive data, provide additional understanding behind increased prevalence rates.Data on obesity and diabetes from the South Australian (SA monthly chronic disease and risk factor surveillance system from July 2002 to December 2013 (n = 59,025 were used. Age was the self-reported age of the respondent at the time of the interview. Period was the year of the interview and cohort was age subtracted from the survey year. Cohort years were 1905 to 1995. All variables were treated as continuous. The age-sex standardised prevalence for obesity and diabetes was calculated using the Australia 2011 census. The APC models were constructed with ''apcfit'' in Stata.The age-sex standardised prevalence of obesity and diabetes increased in 2002-2013 from 18.6% to 24.1% and from 6.2% to 7.9%. The peak age for obesity was approximately 70 years with a steady increasing rate from 20 to 70 years of age. The peak age for diabetes was approximately 80 years. There were strong cohort effects and no period effects for both obesity and diabetes. The magnitude of the cohort effect is much more pronounced for obesity than for diabetes.The APC analyses showed a higher than expected peak age for both obesity and diabetes, strong cohort effects with an acceleration of risk after 1960s for obesity and after 1940s for diabetes, and no period effects. By simultaneously considering the effects of age, period and cohort we have provided additional evidence for effective public health interventions.

  6. Molecular cloning and characterization of four genes encoding ethylene receptors associated with pineapple (Ananas comosus L. flowering

    Directory of Open Access Journals (Sweden)

    Yunhe eLi

    2016-05-01

    Full Text Available Exogenous ethylene, or ethephon, has been widely used to induce pineapple flowering, but the molecular mechanism behind ethephon induction is still unclear. In this study, we cloned four genes encoding ethylene receptors (designated AcERS1a, AcERS1b, AcETR2a and AcETR2b. The 5′ flanking sequences of these four genes were also cloned by self-formed adaptor PCR and SiteFinding-PCR, and a group of putative cis-acting elements was identified. Phylogenetic tree analysis indicated that AcERS1a, AcERS1b, AcETR2a and AcETR2b belonged to the plant ERS1s and ETR2/EIN4-like groups. Quantitative real-time PCR showed that AcETR2a and AcETR2b (subfamily 2 were more sensitive to ethylene treatment compared with AcERS1a and AcERS1b (subfamily 1. The relative expression of AcERS1b, AcETR2a and AcETR2b was significantly increased during the earlier period of pineapple inflorescence formation, especially at 1-9 days after ethylene treatment (DAET, whereas AcERS1a expression changed less than these three genes. In situ hybridization results showed that bract primordia (BP and flower primordia (FP appeared at 9 and 21 DAET, respectively, and flowers were formed at 37 DAET. AcERS1a, AcERS1b, AcETR2a and AcETR2b were mainly expressed in the shoot apex at 1-4 DAET; thereafter, with the appearance of BP and FP, higher expression of these genes was found in these new structures. Finally, at 37 DAET, the expression of these genes was mainly focused in the flower but was also low in other structures. These findings indicate that these four ethylene receptor genes, especially AcERS1b, AcETR2a and AcETR2b, play important roles during pineapple flowering induced by exogenous ethephon.

  7. Molecular Cloning and Characterization of Four Genes Encoding Ethylene Receptors Associated with Pineapple (Ananas comosus L.) Flowering.

    Science.gov (United States)

    Li, Yun-He; Wu, Qing-Song; Huang, Xia; Liu, Sheng-Hui; Zhang, Hong-Na; Zhang, Zhi; Sun, Guang-Ming

    2016-01-01

    Exogenous ethylene, or ethephon, has been widely used to induce pineapple flowering, but the molecular mechanism behind ethephon induction is still unclear. In this study, we cloned four genes encoding ethylene receptors (designated AcERS1a, AcERS1b, AcETR2a, and AcETR2b). The 5' flanking sequences of these four genes were also cloned by self-formed adaptor PCR and SiteFinding-PCR, and a group of putative cis-acting elements was identified. Phylogenetic tree analysis indicated that AcERS1a, AcERS1b, AcETR2a, and AcETR2b belonged to the plant ERS1s and ETR2/EIN4-like groups. Quantitative real-time PCR showed that AcETR2a and AcETR2b (subfamily 2) were more sensitive to ethylene treatment compared with AcERS1a and AcERS1b (subfamily 1). The relative expression of AcERS1b, AcETR2a, and AcETR2b was significantly increased during the earlier period of pineapple inflorescence formation, especially at 1-9 days after ethylene treatment (DAET), whereas AcERS1a expression changed less than these three genes. In situ hybridization results showed that bract primordia (BP) and flower primordia (FP) appeared at 9 and 21 DAET, respectively, and flowers were formed at 37 DAET. AcERS1a, AcERS1b, AcETR2a, and AcETR2b were mainly expressed in the shoot apex at 1-4 DAET; thereafter, with the appearance of BP and FP, higher expression of these genes was found in these new structures. Finally, at 37 DAET, the expression of these genes was mainly focused in the flower but was also low in other structures. These findings indicate that these four ethylene receptor genes, especially AcERS1b, AcETR2a, and AcETR2b, play important roles during pineapple flowering induced by exogenous ethephon.

  8. Disease: H00912 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00912 Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic... fever The tumor necrosis factor receptor-associated periodic sydrome (TRAPS) is a multisystem aut..., Wong K, McDermott EM, Dean J, Powell RJ, Kastner DL The TNF receptor-associated periodic syndrome (TRAPS):...8 (2002) PMID:16447098 (description, gene) Rezaei N TNF-receptor-associated periodic syndrome (TRAPS): an au...s AA, Oliveira JB, Aksentijevich I, Fujihira E, Carneiro-Sampaio MM, Duarte AJ, Silva CA TNF receptor-associated periodic

  9. Antiproliferative effects of Bortezomib in endothelial cells transformed by viral G protein-coupled receptor associated to Kaposi's sarcoma.

    Science.gov (United States)

    Suares, A; Mori Sequeiros Garcia, M; Paz, C; González-Pardo, V

    2017-04-01

    The Kaposi's Sarcoma-associated Herpes virus G Protein-Coupled Receptor (vGPCR) is a key molecule in the pathogenesis of Kaposi Sarcoma. We have previously demonstrated that the proteasome inhibitor Bortezomib inhibits NF-κB pathway, which is required for tumor maintenance in endothelial cells that express vGPCR (vGPCR cells). In this work, we further investigated Bortezomib anti-proliferative mechanism of action. We demonstrated that Bortezomib decreases vGPCR cell number in a dose-dependent manner and induces cell morphology changes. Bortezomib decreases ERK1/2 phosphorylation whereas induces the accumulation of MKP-3 - a specific ERK1/2 MAP kinase phosphatase - in time and concentration dependent manner (1.5-32h; 0.25-1nM). The transcription factor FOXO1 is activated by dephosphorylation and regulates p21 expression. Here, we demonstrated that Bortezomib increases FOXO1 protein and decreases its phosphorylation in a concentration dependent manner (0.25-1nM). Bortezomib (0.5nM, 24h) also increase nuclear FOXO1 protein, in line with FOXO1 dephosphorylation induced by the drug. Consistent with FOXO1 dephosphorylation/activation, p21 mRNA expression is increased by Bortezomib in a MKP-3-dependent way. Bortezomib (0.5nM, 24h) also decreases VEGF, an ERK1/2 -dependent effect. It is concluded that in vGPCR cells, Bortezomib decreases ERK1/2 and FOXO1 phosphorylation through MKP-3 accumulation, leading ERK1/2 deactivation and FOXO1 activation respectively and, consequently, to cell proliferation inhibition, p21 induction and VEGF repression. Taken together, all these events contribute to the anti-tumoral effect of Bortezomib.

  10. Fatores de risco associados ao desmame precoce e ao período de desmame em lactentes matriculados em creches Risk factors associated to early weaning and to weaning period of infants enrolled in daycare centers

    Directory of Open Access Journals (Sweden)

    Marina Borelli Barbosa

    2009-09-01

    weaning and short weaning period (defined as the difference between exclusive breastfeeding period and total breastfeeding period were determined by bivariate analyses. Conceptual hierarchical multivariate analysis (logistic regression was applied. RESULTS: In the multivariate analysis, the independent risk factors for early weaning were: family income 25 years (OR 4.91; 95%CI 1.35-17.95; mother living without a partner (OR 6.42; 95%CI 1.28-32.20; use of pacifier before 30 days of life (OR 8.75; 95%CI 1.90-40.23. Risk factors for insufficient weaning period were: attending public daycare centers (OR 3.20; 95%CI 0.77-14.29 and late start of prenatal care (OR 4.13; 95%CI 0.70-31.29. CONCLUSIONS: Characteristics related to family and to daycare centers are risk factors for breastfeeding weaning among institutionalized infants. Such factors approach is strategic to define nutrition and health actions for favoring breastfeeding practice and to qualify daycare centers as infant health and nutrition promoters.

  11. 男男性行为人群 HIV 抗体定期检测及其影响因素分析%An analysis on the status of HIV periodic testing and its influencing factors among MSM

    Institute of Scientific and Technical Information of China (English)

    周娓; 元国平; 岑焕新

    2016-01-01

    Objective To learn the current status of HIV periodic testing and its influencing factors among MSM in Ningbo,and to provide evidence for the intervention.Methods Men who had oral sex and anal sex with men 1 2 months before the survey were recruited by respondent driven sampling (RDS)method,and questionnaire investigation and HIV, syphilis testing were conducted.Characteristics of sexual behavior,history of HIV testing,detection and treatment will of MSMwere analyzed.Results A total of 1 26 MSM were recruited and 84.1 3% were willing to undergo periodic testing. Totally 70.02% of them were tested previously,and 89.1 3% were detected by voluntary counseling and testing,and 46.03% could participate periodic testing.Multivariate logistic regression analysis showed that age (OR =2.62,95%CI:1 .06 -6.51 ),have received professional personnel,propaganda and intervention (OR =0.08,95%CI:0.02 -0.25), understanding of AIDS antiviral therapy (OR =0.25,95%CI:0.09 -0.67)were the influencing factors for the periodic testing among MSM.Conclusion The rate of MSM who followed periodic testing is low,but the demand for periodic testing of them is high.AIDS prevention and behavioral intervention among MSM should be strengthened,especially for teenager,to expand the detection coverage and to promote periodic testing.%目的:了解宁波市男男性行为(MSM)人群 HIV 抗体定期检测现状及其影响因素,为 MSM人群定期检测干预提供依据。方法采用同伴推动抽样法招募最近十二个月与同性发生过口交和(或)肛交性行为的 MSM进行问卷调查和 HIV 抗体、梅毒抗体检测,分析性行为特征、HIV 抗体检测史以及检测与治疗意愿等。结果共招募 MSM126人,其中84.13%愿意接受定期检测;73.02%既往做过 HIV 检测,其中通过自愿咨询检测途径占89.13%;46.03%有定期检测习惯。多因素 Logistic 回归分析显示,年龄(OR =2.62,95%CI:1.06~6.51

  12. Prevalence of dental caries and influencing factors, time trends over a 30-year period in an adult population. Epidemiological studies between 1983 and 2013 in the county of Dalarna, Sweden.

    Science.gov (United States)

    Edman, Kristina; Öhrn, Kerstin; Nordström, Birgitta; Holmlund, Anders

    2016-07-01

    The aim of this study was to investigate the prevalence of dental caries in an adult population using four different cross-sectional studies over a 30-year period and to assess its possible associations with socio-economic and socio-behavioural factors. Four cross-sectional epidemiological studies were performed in the county of Dalarna, Sweden, in 1983, 2003, 2008 and 2013. Random samples of 1012-2244 individuals, aged 20-85 years, who answered a questionnaire about socio-economic and socio-behavioural factors, were radiographically and clinically examined. The proportion of individuals with at least one decayed surface (DS) was 58% in 1983 and significantly lower, 34% in 2008 (p dental visits, limited financial resources for dental care, smoking, education below university, male gender, daily medication and single living were positively and statistically associated with manifest caries. The declining trend in the prevalence of manifest caries seems to be broken. In the oldest age group mean number of DS was higher in 2013 compared with 2008, indicating a possible beginning of an increase. This needs special attention as this group increases in the population, retaining natural teeth high up in age. Manifest caries was found to be associated with socio-economic and socio-behavioural factors.

  13. Increase of AMPA receptor glutamate receptor 1 subunit and B-cell receptor-associated protein 31 gene expression in hippocampus of fatigued mice.

    Science.gov (United States)

    Kamakura, Masaki; Tamaki, Keisuke; Sakaki, Toshiyuki; Yoneda, Yukio

    2005-10-14

    Central fatigue is an indispensable biosignal for maintaining life, but the neuronal and molecular mechanisms involved remain unclear. In this study, we searched for genes differentially expressed in the hippocampus of fatigued mice to elucidate the mechanisms underlying fatigue. Mice were forced to swim in an adjustable-current water pool, and the maximum swimming time (endurance) until fatigue was measured thrice. Fatigued and nonfatigued mice with equal swimming capacity and body weight were compared. We found that the genes of GluR1 and B-cell receptor-associated protein 31 (Bap31), which acts as a transport molecule in the secretory pathway or as a mediator of apoptosis, were upregulated in the hippocampus of fatigued mice, and increases of GluR1 and Bap31 were confirmed by Northern blotting and real-time PCR. No change of gene expression of AMPA receptor subunits other than GluR1 was observed. These results suggest that a compositional change of AMPA receptor (increase of GluR1) and upregulation of the Bap31 gene may be implicated in fatigue in mice.

  14. N-methyl-D-aspartate receptor inhibition by an apolipoprotein E-derived peptide relies on low-density lipoprotein receptor-associated protein.

    Science.gov (United States)

    Sheng, Zhenyu; Prorok, Mary; Brown, Brigid E; Castellino, Francis J

    2008-08-01

    The effects of a synthetic apoE peptide, viz., residues 133-149 (apoE[133-149]), a mimetic that comprises the apoE receptor binding domain, on N-methyl-D-aspartate (NMDA)/glycine-induced ion flow through NMDA receptor (NMDAR) channels, have been investigated. The activity of apoE[133-149] was found to depend on the low-density lipoprotein receptor-related protein (LRP). Competition experiments with receptor-associated protein (RAP) and activated alpha(2)-macroglobulin (alpha(2)M*), two proteins that compete for apoE binding to LRP, demonstrate that apoE[133-149] inhibition of NMDAR function is mediated at a locus in LRP that overlaps with the binding sites of RAP and alpha(2)M*. A coreceptor of LRP, cell surface heparin sulfate proteoglycan, did not function in this system. Additional electrophysiology experiments demonstrated that the inhibitory potency of apoE[133-149] was threefold greater for NMDAR-transfected wild-type Chinese hamster ovary (CHO) cells compared with NMDAR-transfected CHO cells deficient in LRP. Studies with truncation and replacement variants of the apoE peptide demonstrated that the NMDAR inhibitory properties of these peptides correlate with their binding affinities for LRP. These novel results indicate that apoE functions as an inhibitor of NMDAR ion channels indirectly via LRP, and are suggestive of a participatory role for LRP in NMDAR-based neuropathies.

  15. 云南农村育龄妇女围孕期风险因素调查%Investigation on the risk factors of rural women of childbearing age during periconception period in Yunnan

    Institute of Scientific and Technical Information of China (English)

    速存梅; 叶汉风; 袁彦玲; 王建兰; 张明秋; 李根瑞; 陈涓涓

    2011-01-01

    Objective: To understand the exposure status of risk factors of rural women of childbearing age during periconception period in Yunnan, provide a informational support for carrying out prenatal examination.Methods: Questionnaires were used to survey 8 765 rural women of childbearing age by investigators, 8 663 copies of the questionnaires were obtained.Results: The proportions of unintended pregnancy, passive smoking and unbalanced diet among the women of childbearing age during periconception period were 44.8%, 44.5% and 41.0%, respectively.30.8% of the women lived in recently renovated houses or with new furniture.25% of the women watched TV for a long time or stayed up all night, contacted ionizing radiation and cats/dogs.Partial women chose vegetarian diet, ate raw meat or undercooked meat, drank coffer or strong tea, contacted toxic substances, which are risk factors of inducing adverse pregnancy outcomes.Conclusion: The proportion of rural women of childbearing age during perieonception period exposed to adverse effect factors is high.Enhancing health education and health promotion during progestational and periconception period, changing adverse behaviors of the women of childbearing age may relieve and reduce the risk factors of pregnancy.%目的:了解云南农村育龄妇女围孕期风险因素的暴露情况,为开展孕前优生健康检查提供信息支持.方法:采用问卷调查由经过统一培训的调查员逐户人户对8765例育龄妇女进行调查,共同收有效问卷8 663份.结果:围孕期育龄妇女暴露风险因素比例最多的是非计划怀孕、被动吸烟、偏食,分别占44.8%、44.5%、41.0%.30.8%的妇女居住的室内进行过新装修或购置了新家具.近1/4的妇女长时问看电视/熬夜、接触电离辐射、接触猫狗.有一部分妇女仍然素食、食用生肉或未煮熟的肉类食物、喝咖啡/浓茶、接触有害化学物质等可引起不良妊娠结局的风险因素.结论:农村

  16. 新型甲型H1N1流感潜伏期及其影响因素分析%The Analysis of Influenza A( H1N1 ) Incubation Period and its Influencing Factors

    Institute of Scientific and Technical Information of China (English)

    陈雄飞; 李铁钢; 柳洋; 王玉林; 陈希; 刘建华; 李美霞; 王鸣

    2011-01-01

    Objective To estimate incubation period of Pandemic Influenza A( H1N1) and to analyze the influencing factors. Methods Data from a Pandemic Influenza A( H1N1) outbreak in a closed environment was analyze with parametric survival analysis model to estimate Pandemic Influenza A(H1N1) incubation period, describe its characteristics ,and explore the influencing factors. Results The incubation period of Pandemic Influenza A(H1N1) is 4.65 days on average,whose 95% confidence interval is (4.02,5.27) days. After infection ,72.34% of cases are onset in 7 days and 95% of cases are onset in 12. % days. Comparing to Exponential, lognormal and weibull distribution. Gamma distribution is the best distribution to describe this outbreak,No factor had found that can affect the incubation period by univariate analysis of 41 factors. By multivariate analysis, we found that the average incubation period of those wearing a mask when accessing to public places is 1.21 times of those not wearing a mask, the average incubation period of those regularly cleaning the dormitory is 70% of those not regularly cleaning the dormitory,and the average incubation period of those often going to crowded places with poor ventilation is 45% of those not often going to this places. Conclusion Parametric sur-vival analysis model can describe the characteristics of Pandemic Influenza A( H1N1) incubation period appropriately. The time of medical observation or isolation of close contacts is 14 days for the best. General non-ventilated protective measures,such as wearing masks,cleaning,avoid visiting crowded and poorly ventilated place,is effective in protecting vulnerable persons.%目的 估计新型甲型H1N1流感潜伏期并分析其影响因素,为新型甲型H1N1流感的防控提供决策参考.方法 利用来源于一次封闭环境下的新型甲型H1N1流感暴发数据,采用失效数据的参数生存分析模型,对新型甲型H1N1流感的潜伏期进行估计,

  17. 老年肺癌患者化疗期间抑郁相关危险因素分析%Risk factors of depression in elderly patients with lung cancer during chemotherapy period

    Institute of Scientific and Technical Information of China (English)

    程丽; 郭红桃

    2016-01-01

    目的:探讨老年肺癌患者化疗期间抑郁相关危险因素,为临床实施针对性心理干预提供参考。方法选择2012年9月至2015年10月本院收治的253例老年肺癌患者为研究对象。通过抑郁量表(GDS)调查老年肺癌患者化疗期间抑郁的发生情况,对患者的临床资料进行单因素分析,采用Logistic回归分析老年肺癌患者化疗期间抑郁相关危险因素。结果253例老年肺癌患者化疗期间121例患者被诊断为抑郁,化疗期间抑郁发生率为47.83%;单因素分析显示,抑郁患者中了解病情、女性、高中以下文化水平、家庭月收入低于2750元、Ⅱ度及以上疼痛、曾行肺癌针对性手术治疗的患者比例均显著高于非抑郁患者(P<0.05);多因素非条件的Logistic回归分析显示,了解病情、女性、高中以下文化水平、家庭月收入低于2750元、Ⅱ度及以上疼痛为老年肺癌患者化疗期间发生抑郁的危险因素。结论在老年肺癌患者化疗期间应,临床医师根据其收入、性别、文化程度进行个体化干预,并积极降低患者癌痛程度,从而减少化疗期间抑郁的发生,改善患者预后。%Objective To explore the risk factors of depression in elderly patients with lung cancer during chemotherapy period, and to provide reference for clinical practice. Method From September 2012 to October 2015, 253 cases of elderly patients with lung cancer in our hospital were selected as research objects. Evaluated patients' symptoms of depression during chemotherapy period by Geriatric Depression Scale (GDS). The clinical data of patients were analyzed by single factor analysis, and used Logistic regression analysis to analyze the risk factors of depression in elderly patients with lung cancer during chemotherapy period. Result 121 patients were diagnosed as depression in 253 cases, the incidence rate of depression was 47.83%;the single factor analysis showed

  18. Analysis of anxiety influencing factors of computer department students in vocation selecting period%择业期计算机专业学生焦虑成因分析

    Institute of Scientific and Technical Information of China (English)

    陈贞娥; 唐济生; 张天亮

    2008-01-01

    目的 探讨计算机专业应届毕业生择业期焦虑水平的影响因素.方法 采用分层整群抽样,对计算机专业363名应届毕业生,用卡特尔16种人格因素(16PF)问卷、症状自评量表(SCL-90)、应付方式问卷、高校毕业生择业焦虑及原因调查问卷施测.结果 择业期计算机专业学生焦虑水平显著高于全国青年常模(t=6.631,P=0.000).多元逐步回归分析发现,紧张性(标准回归系数0.24928,t=4.72,P=0.000)、择业竞争压力(标准回归系数0.22126,t=4.54,P=0.000)、忧虑性(标准回归系数0.18320,t=3.36,P=0.001)、怀疑性(标准回归系数0.15002,t=3.16,P=0.002)、残缺家庭(标准回归系数0.09474,t=2.17,P=0.031)是影响择业期计算机学生焦虑水平的主要因素.结论 择业期焦虑水平受多种因素的影响,高怀疑、高紧张等不健康个性是择业期焦虑问题的内因,择业竞争压力是促发因素,家庭残缺对学生处事应变能力有不良影响.%Objective To explore the anxiety influencing factors of students of computer department in vocation selecting period.Methods A total of 363 students of computer department in periods of vocational selection were assessed with 16PF, SCL-90, Coping Style Questionnaire,and Vocational Selection Anxiety Questionnaire for University Graduate. Results The anxiety score of students of computer department in vocation selecting period were much higher statisticaly than the Chinese youth norm(t=6.631,P=0.000).The results of multivariable stepwise regression showed that the major factors affecting the anxiety score of the students were anxiousness (stb=0.24928,t=4.72,P<0.000),press of employment compete(stb=0.22126,t=4.54,P<0.000),apprehension(stb=0.18320,t=3.36, P=0.001),vigilance (stb=0.15002,t=3.16, P=0.002), family-incompleteness (stb=0.09474,t=2.17, P=0.031)et al. Conclusion The anxiety score were affected by many factors. Unhealthy personality such as high vigilance and high anxiousness are the

  19. 长周期桥梁地震设计谱阻尼修正系数研究%Study on Damping Modification Factor of Response Spectrum for Long-period Bridge

    Institute of Scientific and Technical Information of China (English)

    郭太军; 薛瑞杰

    2011-01-01

    阻尼比是影响反应谱值的一个重要参数.当结构阻尼比发生变化时,会显著地改变反应谱值,从而影响结构所受地震作用的大小.规范设计反应谱均以一个标准阻尼比为基准,当结构主要振型的阻尼比偏离此标准值较多时,通过修正系数对设计反应谱进行修正.本文比较了各国桥梁抗震设计规范地震设计谱阻尼修正公式,并选取3条含有长周期分量的地震波对一长周期单自由度系统进行时程分析,使用瑞利阻尼,阻尼比从0.01 ~0.10变化,每种阻尼比计算结果取3条地震波的平均值,并与阻尼比为0.05的结果相比得到修正系数.在与各规范公式结果相比较后得出结论:欧洲规范阻尼修正公式更适用于长周期桥梁.%Damping ratio is an important parameter of response spectrum, for it can significally change the earthquake force by influencing response spectrum values. Design response spectrum is generally based on an constant damping ratio, when this constant is deviated from the danmping ratio of structural chief modal far away, the spectrum value would be modificated by a factor. In this paper, the damping ratio modification formulas of bridge seismic design codes in domestic and overseas are compared, and a series of time history analysis of long-period single degree of freedom systems is carried out using three earthquake waves including long period component, damping ratio varied from 0.01 to 0. 10 increasing by 0.01 using Rayleigh damping. The calculation result of every damping ratio is taken the average value of three waves, dividing the result of 0. OS damping ratio, the modification factor is obtained. Compared with the results of damping ratio modification formula in different bridge seismic design codes, it is concluded that Eurocode formula is more applicable to long-period bridge.

  20. Fatores maternos e resultados perinatais no descolamento prematuro da placenta: comparação entre dois períodos Maternal factors and perinatal results in placental abruption: a comparative study of two periods

    Directory of Open Access Journals (Sweden)

    Roseli Mieko Yamamoto Nomura

    2006-06-01

    Full Text Available OBJETIVOS: comparar o perfil dos fatores maternos, aspectos clínicos e os resultados perinatais no descolamento prematuro da placenta (DPP, em dois períodos. MÉTODOS: avaliação retrospectiva dos casos de DPP ocorridos entre 01 de janeiro de 1994 e 31 de dezembro de 1997 (período 94-97, e entre 1 de abril de 2001 e 31 de março de 2005 (período 01-05, em gestações únicas com peso do recém-nascido superior a 500 g e idade gestacional acima da 20ª semana. Foram analisados os fatores: idade materna, cor, antecedentes obstétricos, pré-natal, rotura prematura de membranas, intercorrências clínicas e/ou obstétricas, sangramento, tônus uterino, malformação fetal, tipo de parto, hemoâmnio e complicações maternas (histerectomia, atonia uterina, CIVD, insuficiência renal aguda e morte materna, e os resultados perinatais. RESULTADOS: no período 94-97, foram realizados 7692 partos e o DPP ocorreu em 0,78% (60 casos, e, no período 01-05, foram 8644 partos com 0,59% (51 casos de DPP (sem diferença significativa. Observou-se diferença significativa entre os períodos 94-97 e 01-05 em relação à média do número de gestações (3,5±2,4 e 2,6±1,8; p=0,04, não realização de pré-natal (13,3 e 2,0%; p=0,03 e intercorrências maternas (38,3 e 64,7%; p=0,01. Não foram observadas diferenças significativas quanto ao sangramento, à alteração no tônus e aos resultados perinatais, entre os períodos, verificando-se apenas maior proporção de hemoâmnio no período 94-97 que no 01-05 (28,3 e 11,8%, p=0,03. CONCLUSÕES: apesar dos avanços da obstetrícia, as complicações maternas e os resultados perinatais foram semelhantes nos períodos analisados. A gravidade e a imprevisibilidade do fenômeno alertam para a prevenção e controle adequados diante dos fatores associados ao DPP, na abordagem desta doença.PURPOSE: to compare the maternal factors, clinical aspects and perinatal results in placental abruption during two periods

  1. INFLUENCING FACTORS AFFECTING STRESS LEVEL OF FAMILY MEMBERS OF CERVICAL CANCER PATIENTS DURING PERIOPERATIVE PERIOD%宫颈癌围手术期患者家属应激水平影响因素分析

    Institute of Scientific and Technical Information of China (English)

    张慧芳; 颜春英

    2015-01-01

    目的::探讨宫颈癌围手术期患者家属应激水平的影响因素,为制定相关心理干预措施提供理论依据。方法:应用家属应激量表(RSS)、焦虑自评量表(SAS)和抑郁自评量表(SDS)调查90例宫颈癌围手术期患者家属的应激水平和焦虑、抑郁状况,并采用Pearson直线相关分析和Stepwise多元线性回归分析分析影响患者家属应激水平的因素。结果:宫颈癌围手术期患者家属应激反应水平较高,焦虑情况较轻,存在中至重度抑郁。直线相关分析显示,RSS及其三个因子评分与焦虑、抑郁均呈正相关关系(P<0.05)。多元线性回归分析表明,家属的民族、宗教信仰、家庭类型、焦虑、抑郁水平是影响其应激水平的因素(P<0.05)。结论:宫颈癌患者家属在围手术期同样存在严重的心理问题,医护人员应给予切实有效的心理指导,降低患者家属的心理应激水平。%Objective:To investigate the inlfuencing factors affecting stress level of family members of cervical cancer patients during perioperative period and provide theoretical basis for formulating psychological intervention measures. Methods:RSS scale, SAS scale and SDS scale were used to evaluate the stress level, anxiety and depression status of family members of cervical cancer patients during perioperative period; Pearson linear correlation analysis and Stepwise multiple linear regression analysis were applied to analyze the inlfuencing factors affecting stress level of family members of cervical cancer patients.Results:The stress level of family members of cervical cancer patients was higher; the anxiety status was lighter but the depression status was moderate to severe. Linear correlation analysis showed RSS and its’ 3 factors positively correlated with anxiety and depression status. Multiple linear regression analysis showed nation, religion, family type, anxiety level and depression level were

  2. Factors that Affect the Adherence to ADHD Medications during a Treatment Continuation Period in Children and Adolescents: A Nationwide Retrospective Cohort Study Using Korean Health Insurance Data from 2007 to 2011

    Science.gov (United States)

    Bhang, Soo-Young; Kwack, Young Sook; Joung, Yoo-Sook; Lee, Soyoung Irene; Kim, Bongseog; Sohn, Seok Han; Chung, Un-Sun; Yang, Jaewon; Hong, Minha; Bahn, Geon Ho; Choi, Hyung-yun; Oh, In Hwan; Lee, Yeon Jung

    2017-01-01

    Objective Several factors, such as male gender, older age, type of insurance, comorbid conditions, and medication type, have been associated with attention-deficit/hyperactivity disorder (ADHD) medication adherence rates, but the results have been inconsistent. We analyzed data to answer several questions: 1) How old were patients who first refilled their treatment medications used primarily for ADHD, regardless of the medication type? 2) What socio-demographic factors are associated with medication adherence? 3) What medical conditions, such as medication type and comorbid diagnosis, influence adherence? Methods We analyzed National Health Insurance data, which comprised continuously enrolled Korean National Medical Insurance children (6–18 years) with at least 2 ADHD prescription claims (January 2008–December 2011). The persistence of use regarding the days of continuous therapy without a 30-day gap were measured continuously and dichotomously. Adherence, using a medication possession ratio (MPR), was measured dichotomously (80% cut-off). Results The cumulative incidence of index cases that initiated medication refills for ADHD treatment during the 4 year period was 0.85%. The patients who exhibited a MPR greater than 80 comprised approximately 66%. The medication type, high school age groups, physician speciality, treatment at a private clinic, and comorbid conditions were associated with medication adherence during continuous treatment using a multivariate analysis. Conclusion A better understanding of ADHD treatment patterns may lead to initiatives targeted at the improvement of treatment adherence and persistence. Other factors, including the severity, family history, costs, type of comorbidities, and switching patterns, will be analyzed in future studies.

  3. B-cell receptor-associated protein 31 regulates human embryonic stem cell adhesion, stemness, and survival via control of epithelial cell adhesion molecule.

    Science.gov (United States)

    Kim, Won-Tae; Seo Choi, Hong; Min Lee, Hyun; Jang, Young-Joo; Ryu, Chun Jeih

    2014-10-01

    B-Cell receptor-associated protein 31 (BAP31) regulates the export of secreted membrane proteins from the endoplasmic reticulum (ER) to the downstream secretory pathway. Previously, we generated a monoclonal antibody 297-D4 against the surface molecule on undifferentiated human embryonic stem cells (hESCs). Here, we found that 297-D4 antigen was localized to pluripotent hESCs and downregulated during early differentiation of hESCs and identified that the antigen target of 297-D4 was BAP31 on the hESC-surface. To investigate the functional role of BAP31 in hESCs, BAP31 expression was knocked down by small interfering RNA. BAP31 depletion impaired hESC self-renewal and pluripotency and drove hESC differentiation into multicell lineages. BAP31 depletion hindered hESC proliferation by arresting cell cycle at G0/G1 phase and inducing caspase-independent cell death. Interestingly, BAP31 depletion reduced hESC adhesion to extracellular matrix (ECM). Analysis of cell surface molecules showed decreased expression of epithelial cell adhesion molecule (EpCAM) in BAP31-depleted hESCs, while ectopic expression of BAP31 elevated the expression of EpCAM. EpCAM depletion also reduced hESC adhesion to ECM, arrested cell cycle at G0/G1 phase and induced cell death, producing similar effects to those of BAP31 depletion. BAP31 and EpCAM were physically associated and colocalized at the ER and cell surface. Both BAP31 and EpCAM depletion decreased cyclin D1 and E expression and suppressed PI3K/Akt signaling, suggesting that BAP31 regulates hESC stemness and survival via control of EpCAM expression. These findings provide, for the first time, mechanistic insights into how BAP31 regulates hESC stemness and survival via control of EpCAM expression.

  4. Genomic structure analysis of SNC6, a progesterone-receptor associated protein gene, and cloning and characterization of its 5'-flanking region . 

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    Objective: To analyze the genomic structure of SNC6, a progesterone-receptor associated protein gene and its regulatory elements in its 5'-flanking region. Methods: Genomic sequence from GenBank database (accession number: Z98048) covering the whole SNC6 gene was used to analyze the genomic structure of SNC6 and design primers for PCR amplification of its 5'-flanking region. A 1894 bp fragment of the 5'-flanking region (-1814 to +75) was cloned by PCR using genomic DNA from a healthy donor peripheral blood lymphocyte as template. This fragment, as well as 3 shorter derivative fragments (1423 bp, 632 bp and 416 bp, which correspond to -1344 to +75, -552 to +75 and -337 to +75 respectively), were subcloned into pGL2 series luciferase reporter vectors. These constructs were introduced into colorectal cancer cell line SW620 for transient expression of reporter gene and luciferase activities were measured. Results: The genomic structure analysis showed there are 12 exons for SNC6 gene, which spans 32017 bp (nt71529 to nt39513 in Z98048 sequence). All transfected SW620 cells with the above 5-flanking region-containing constructs showed luciferase activities. The highest luciferase activities were measured in transfected cells with vectors containing 1894 bp fragments, and the lowest luciferase activities were measured in transfected cells with vectors containing 416 bp fragments. Luciferase activities were higher in transfected cells with vectors containing 632 bp fragments than that in transfected cells with vectors containing 1423 bp fragments. Conclusion: The basic transcription-promoting element (promoter) for SNC6 expression resides between 0 to -337, and two transcription-enhancing elements (enhancer) resides between -337 to -552 and -1344 to -1814, whereas one transcription-inhibiting element (silencer) exists between -552 to -1344.

  5. Binding of thyroglobulin (Tg) to the low-density lipoprotein receptor-associated protein (RAP) during the biosynthetic pathway prevents premature Tg interactions with sortilin.

    Science.gov (United States)

    Botta, R; Lisi, S; Rotondo Dottore, G; Vitti, P; Marinò, M

    2017-04-05

    Sortilin, a Vps10p family member, is expressed by thyroid epithelial cells (TEC), where it binds to internalized thyroglobulin (Tg) molecules. Premature binding of Tg to sortilin during biosynthesis may cause intracellular retention of Tg. Such a premature interaction may be prevented by one or more inhibitor/s. Because both sortilin and Tg bind to the low-density lipoprotein receptor-associated protein (RAP), we investigated whether RAP serves such a function. Immunofluorescence staining for sortilin, Tg, and RAP was performed in FRTL-5 cells. Co-immunoprecipitation experiments were performed in extracts from FRTL-5 or COS-7 cells, the former co-transfected with Tg and/or RAP and/or sortilin, or in thyroid extracts from RAP KO mice. Tg and sortilin did not co-localize in FRTL-5 cells following inhibition of protein synthesis, suggesting that newly synthesized, endogenous sortilin and Tg do not interact, in confirmation of which an anti-sortilin antibody did not co-precipitate Tg in FRTL-5 cells. In contrast, Tg co-localized with RAP in FRTL-5 cells. Co-immunoprecipitation of Tg with an anti-sortilin antibody in COS-7 cells transfected with sortilin and Tg was abolished when cells were co-transfected with RAP, indicating that RAP prevents binding of Tg to sortilin during biosynthesis, in confirmation of which an anti-sortilin antibody co-precipitated Tg in thyroid extracts from RAP KO mice to a greater extent than in thyroid extracts from WT mice. Tg does not bind prematurely to sortilin because of its interaction with RAP during protein biosynthesis. These findings add new information to the knowledge of thyroid physiology.

  6. Angiotensin-2-mediated Ca2+ signaling in the retinal pigment epithelium: role of angiotensin-receptor-associated-protein and TRPV2 channel.

    Directory of Open Access Journals (Sweden)

    Rene Barro-Soria

    Full Text Available Angiotensin II (AngII receptor (ATR is involved in pathologic local events such as neovascularisation and inflammation including in the brain and retina. The retinal pigment epithelium (RPE expresses ATR in its AT1R form, angiotensin-receptor-associated protein (Atrap, and transient-receptor-potential channel-V2 (TRPV2. AT1R and Atrap co-localize to the basolateral membrane of the RPE, as shown by immunostaining. Stimulation of porcine RPE (pRPE cells by AngII results in biphasic increases in intracellular free Ca(2+inhibited by losartan. Xestospongin C (xest C and U-73122, blockers of IP3R and PLC respectively, reduced AngII-evoked Ca(2+response. RPE cells from Atrap(-/- mice showed smaller AngII-evoked Ca(2+peak (by 22% and loss of sustained Ca(2+elevation compared to wild-type. The TRPV channel activator cannabidiol (CBD at 15 µM stimulates intracellular Ca(2+-rise suggesting that porcine RPE cells express TRPV2 channels. Further evidence supporting the functional expression of TRPV2 channels comes from experiments in which 100 µM SKF96365 (a TRPV channel inhibitor reduced the cannabidiol-induced Ca(2+-rise. Application of SKF96365 or reduction of TRPV2 expression by siRNA reduced the sustained phase of AngII-mediated Ca(2+transients by 53%. Thus systemic AngII, an effector of the local renin-angiotensin system stimulates biphasic Ca(2+transients in the RPE by releasing Ca(2+from cytosolic IP3-dependent stores and activating ATR/Atrap and TRPV2 channels to generate a sustained Ca(2+elevation.

  7. Chronic variable physical stress during the peripubertal-juvenile period causes differential depressive and anxiogenic effects in the novelty-seeking phenotype: functional implications for hippocampal and amygdalar brain-derived neurotrophic factor and the mossy fibre plasticity.

    Science.gov (United States)

    Oztan, O; Aydin, C; Isgor, C

    2011-09-29

    Experimentally naive rats show variance in their locomotor reactivity to novelty, some displaying higher (HR) while others displaying lower (LR) reactivity, associated with vulnerability to stress. We employed a chronic variable physical stress regimen incorporating intermittent and random exposures of physical stressors or control handling during the peripubertal-juvenile period to assess interactions between stress and the LRHR phenotype in depressive- and anxiety-like behaviors on the forced swim and social interaction tests, respectively. A decrease in immobility in the forced swim test along with a decrease in social contact in the social interaction test were observed in the juvenile HRs, coupled with increases in brain-derived neurotrophic factor (BDNF) mRNA in the hippocampus and in the basolateral amygdala with chronic variable physical stress. In contrast, an increase in immobility in the forced swim test and a decrease in social contact was observed in the LR counterparts coupled with an increase in the BDNF mRNA in the basolateral amygdala following chronic variable physical stress. Furthermore, chronic physical stress led to increased H3 and H4 acetylation at the P2 and P4 promoters of the hippocampal BDNF gene in the HR rats that is associated with increased suprapyramidal mossy fibre (SP-MF) terminal field volume. In contrast, chronic variable physical stress led to decreased H4 acetylation at the P4 promoter, associated with decreased SP-MF volume in the LR rats. These findings show dissociation in depressive- and anxiety-like behaviors following chronic variable physical stress in the juvenile HR animals that may be mediated by increased levels of BDNF in the hippocampus and in the amygdala, respectively. Moreover, chronic variable physical stress during the peripubertal-juvenile period results in opposite effects in depressive-like behavior in the LRHR rats by way of inducing differential epigenetic regulation of the hippocampal BDNF gene that, in

  8. Analysis of the Influencing Factors on Sympathetic Inrush in Initial Period of Power Symtem Restoration%电力系统恢复初期和应涌流影响因素分析

    Institute of Scientific and Technical Information of China (English)

    龚薇; 刘俊勇; 贺星棋; 陈井锐; 张国松

    2012-01-01

    电力系统恢复初期机组调节能力有限,在空充主变的过程中存在着由于其饱和导致的和应涌流现象。针对该问题,从电网恢复初期系统模型的等值电路出发,推导出和应涌流与系统主要运行参数之间的关系表达式,分析了已恢复负荷的功率因数、负荷量和变压器的饱和特性对和应涌流产生的影响。并根据系统的实际运行状况建模进行仿真,仿真结果验证了分析的结论,为正确认识系统恢复初期和应涌流现象提供了有益的结论与参考。%In the initial period of power system restoration,because the generator unit regulating ability is limited,the sympathetic inrush current will appear as a result of the saturation when charging no-load transformer.Based on the equivalent circuit of two shunt-wound transforms in initial period of power system restoration,the mathematical representation between sympathetic inrush and main operating parameters was deduced.the influence of load power factor,load capacity and the saturation characteristic of transformers on sympathetic inrush current was analyzed.The process of sympathetic inrush was simulated based on the model with actual situation.The analytical conclusions were verified by computer results obtained and useful conclusion and reference were provided for estimating sympathetic inrush current.

  9. Inverse periodic shadowing properties

    CERN Document Server

    Osipov, Alexey V

    2011-01-01

    We consider inverse periodic shadowing properties of discrete dynamical systems generated by diffeomorphisms of closed smooth manifolds. We show that the $C^1$-interior of the set of all diffeomorphisms having so-called inverse periodic shadowing property coincides with the set of $\\Omega$-stable diffeomorphisms. The equivalence of Lipschitz inverse periodic shadowing property and hyperbolicity of the closure of all periodic points is proved. Besides, we prove that the set of all diffeomorphisms that have Lipschitz inverse periodic shadowing property and whose periodic points are dense in the nonwandering set coincides with the set of Axiom A diffeomorphisms.

  10. Factors Associated With Dropout During Recruitment and Follow-Up Periods of a mHealth-Based Randomized Controlled Trial for Mobile.Net to Encourage Treatment Adherence for People With Serious Mental Health Problems.

    Science.gov (United States)

    Kannisto, Kati Anneli; Korhonen, Joonas; Adams, Clive E; Koivunen, Marita Hannele; Vahlberg, Tero; Välimäki, Maritta Anneli

    2017-02-21

    Clinical trials are the gold standard of evidence-based practice. Still many papers inadequately report methodology in randomized controlled trials (RCTs), particularly for mHealth interventions for people with serious mental health problems. To ensure robust enough evidence, it is important to understand which study phases are the most vulnerable in the field of mental health care. We mapped the recruitment and the trial follow-up periods of participants to provide a picture of the dropout predictors from a mHealth-based trial. As an example, we used a mHealth-based multicenter RCT, titled "Mobile.Net," targeted at people with serious mental health problems. Recruitment and follow-up processes of the Mobile.Net trial were monitored and analyzed. Recruitment outcomes were recorded as screened, eligible, consent not asked, refused, and enrolled. Patient engagement was recorded as follow-up outcomes: (1) attrition during short message service (SMS) text message intervention and (2) attrition during the 12-month follow-up period. Multiple regression analysis was used to identify which demographic factors were related to recruitment and retention. We recruited 1139 patients during a 15-month period. Of 11,530 people screened, 36.31% (n=4186) were eligible. This eligible group tended to be significantly younger (mean 39.2, SD 13.2 years, Pintervention. Attrition from the SMS text message intervention was 4.8% (27/563). The patient dropout rate after 12 months was 0.36% (4/1123), as discovered from the register data. In all, 3.12% (35/1123) of the participants withdrew from the trial. However, dropout rates from the patient survey (either by paper or telephone interview) were 52.45% (589/1123) and 27.8% (155/558), respectively. Almost all participants (536/563, 95.2%) tolerated the intervention, but those who discontinued were more often women (21/27, 78%; P=.009). Finally, participants' age (P<.001), gender (P<.001), vocational education (P=.04), and employment status

  11. Analysis of the generation mechanism and influencing factors on sympathetic inrush in initial period of power system restoration%电网恢复初期和应涌流产生机理及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    龚薇; 刘俊勇; 贺星棋; 张国松

    2012-01-01

    In the initial period of power system restoration, the sympathetic inrush current will appear as a result of the saturation when charging no-load transformer. Based on the mathematical representations of flux linkage and the integral model of sympathetic inrush of two shunt-wound transforms in initial period of power system restoration, this paper indicates that sympathetic inrush is generated through the change of linkage of running transformer by sudden change of public bus voltage in two shunt-wound transformers. The sympathetic inrush value is decided by the integral value of public bus voltage in a period. Then the influence of system impedance, load capacity and load power factor that has been restored on sympathetic inrush current is analyzed in-depth. The analytical results are tested and verified by computer simulation and useful conclusion and reference are provided for estimating sympathetic inrush current.%系统恢复初期,在空充主变的过程中由于其饱和导致和应涌流现象.针对该问题,从并联的两台变压器磁链解析式与和应涌流的积分表达式出发,指出和应涌流主要是由并联变压器公共点处电压的突变造成运行变压器的磁链改变而产生的,其大小由并联公共点处电压在一个周期内的积分值决定.然后深入分析了系统阻抗、运行变压器所带负荷量及负荷功率因数对和应涌流产生的影响.利用计算机仿真验证了分析的结论,为正确认识系统恢复初期和应涌流现象提供了有益的结论与参考.

  12. On Changes of the City Size and Restricting Factors of Cities in Southern Xinjiang In Modern Period%近代南疆城市规模的变化与制约因素论析

    Institute of Scientific and Technical Information of China (English)

    何一民

    2014-01-01

    清代前中期,南疆城市发展比北疆城市缓慢。晚清时期,随着外国资本主义的渗入、新疆建省和清政府推行一系列改革,南疆城市获得了较大发展,呈现出以喀什、和阗为中心的南疆西南城市体系的雏形和以阿克苏为中心的南疆东北城市体系的雏形。民国时期,随着新疆人口的增加和经济的发展,南疆城市人口和城市空间也都有所扩大和变化,尤其是南疆东北部地区的城市变化较为突出。虽然南疆城市在此一时期有所发展,但数量仍然不多,人口规模和空间规模都普遍较小。制约南疆城市发展的因素,除了自然环境脆弱、经济不发达、交通运输落后外,社会动乱、政局变化以及民族、宗教等因素的制约也不可忽略。%In early and middle Qing dynasty, Southern Xinjiang developed slower than Northern Xin-jiang. In late Qing Dynasty, with the infiltration of foreign capitalism, the establishment of Xinjiang prov-ince, and a series of reform measures implemented by the Qing government, the southern Xinjiang cities obtained considerable development. Kashgar, Hetian and Aksu city become the centers of southern Xin-jiang’ s urban system. During the period of the Republic of China, with the increase of population in Xin-jiang and the development of economy, southern Xinjiang urban population and urban space were wid-ened and changed, especially in the northeast region of southern Xinjiang. Although the southern Xin-jiang city achieved a certain degree of development in this period, the cities are not of great number while population and spatial scale were generally small. There were other factors which hindered the urban de-velopment of cities in southern Xinjiang, such as natural geographical environment, undeveloped econo-my, inconvenient transportation, social turmoil, political change, ethnic and religious factors.

  13. Effect of meteorological factors on the main phonological periods of Jatropha curcas L.%气象因子对麻疯树主要物候的影响

    Institute of Scientific and Technical Information of China (English)

    王秀荣; 赵杨; 丁贵杰

    2012-01-01

    Using the climatological data of 2010 and 2011 of Luodian County in Guizhou Province,the effect of meteorological factors on the main phonological period of Jatropha curcas L. were researched.The results showed that among three meteorological factors,temperature was the key factor and acted on the main phonological periods of Jatropha curcas L. .A large Daily Temperature Range(DTR) could help to breaking of tree dormancy.The sap began to flow when the effective accumulative temperature(EAT) was 27—28 ℃·day,new buds appeared when EAT was 30 ℃·day,lamina spread at 35 ℃·day,new twig became long at 76-78 ℃·day,and at the same time,a small amount of inflorescence could be found.When EAT was 110 ℃·day,the floret on inflorescence came into bloom.The stem apex stop growing at about 167 ℃·day and start glowing when EAT reached 220 ℃·day.Finally,when it was 320 ℃·day,the tree began to fall leaves and then came into dormancy.Rainfall is one indispensable factor of growth and development of Jatropha curcas L. .The tree grew fast during the rainy season and came into dormancy against the dry season.Too much rainfall resulted in the hours of light became fewer and the tree stopped growing by lack of synthesis of nutrients.Sunshine hour had little influence on the flower development,but more effect on the growth and development.%利用2010和2011年贵州省罗甸县的气象资料,分析了气象因子对麻疯树主要物候期的影响,结果表明:3个气象因子中,温度是决定麻疯树各主要物候的主要因子.日较差对打破麻疯树休眠有一定的作用,萌芽前日较差加大,有利于营养的大量积累,促进麻疯树解除休眠;有效积温对麻疯树物候的发生有决定性作用,当有效积温达到27~28 d·℃,树液开始流动,超过30 d·℃时,嫩芽开始萌出,35 d·℃以上时,开始展叶,积温达76~78 d·℃时,茎尖抽生新枝,并有花序出现,当积温达到110 d·℃,单

  14. Your First Period

    Science.gov (United States)

    ... Events Advocacy For Patients About ACOG Your First Period (Especially for Teens) Home For Patients Search FAQs ... Teens) FAQ049, May 2015 PDF Format Your First Period (Especially for Teens) Especially For Teens What is ...

  15. Middle Helladic Period

    DEFF Research Database (Denmark)

    Sarri, Kalliopi

    1999-01-01

    The Middle Bronze Age on Mainland Greece is also known as the Middle Helladic period. The chronological framework of this period extends from the beginnings of the second millenium - roughly 1900 - until 1550 BC, that is until the beginnings of the Mycenaean period. The Middle Helladic period...... is considered as the dark period of the cultural decline. The remains of the material culture reveal a clear retrogression while the information available on the social stratification and economy are so few and problematic in interpretation that this period is considered as the "Middle Age of Greek Prehistory......". About 1900 BC, the period during which the first palaces of Crete were being built, Mainland Greece was entering a long period of decline during which economic features changed radically. A large number of metals and imported products became particularly rare while composite forms of economic...

  16. ON PERIODIC DYNAMICAL SYSTEMS

    Institute of Scientific and Technical Information of China (English)

    LU WENLIAN; CHEN TIANPING

    2004-01-01

    The authors investigate the existence and the global stability of periodic solution for dynamical systems with periodic interconnections, inputs and self-inhibitions. The model is very general, the conditions are quite weak and the results obtained are universal.

  17. Functional polymorphism in exon 5 and variant haplotype of the interleukin-1 receptor-associated kinase 1 gene are associated with susceptibility to and severity of sepsis in the Chinese population

    Institute of Scientific and Technical Information of China (English)

    FANG Yu; ZHANG Lu; ZHOU Gang-qiao; WANG Zhi-fu; ZENG Zhao-shu; LUO Zhi-yi; LI Lei; LIU Bao-chi

    2011-01-01

    Background The interleukin-1 (IL-1) receptor-associated kinase 1 (IRAKI) is believed to play an important role in the pathogenesis of sepsis. Recent studies have suggested that the IRAK1 functional genetic variant could affect the severity of sepsis in Caucasians. In this report, we have investigated whether polymorphisms at the IRAK1 gene are associated with the susceptibility to and severity of sepsis among the Chinese population. Methods Haplotype-tagging single nucleotide polymorphisms (htSNPs) were selected from the HapMap database.They were genotyped in 255 patients with sepsis and 260 control subjects by PCR/restriction fragment length polymorphism (RFLP) analysis. The association between the selected htSNPs and the susceptibility to and severity of sepsis were estimated by Logistic regression with adjustments for age, sex, smoking, drinking, chronic disease status,Acute Physiology and Chronic Health Evaluation (APACHE) Ⅱ score and primary diseases. Results rs1059702 was selected to represent the six linked htSNPs for IRAK1. Genotype frequencies of the htSNPs were in Hardy-Weinberg equilibrium for females, as were allele frequencies for both sex groups. Associations were observed in females between the htSNPs C/C genotype and increased susceptibility to sepsis (odds ratio (OR), 5.46;95% confidence interval (Cl), 1.12-26.67; P=0.018), and such associations were also observed between the IRAK1variant haplotype (CC/C-allele) and increased susceptibility to sepsis (OR, 1.68; 95% Cl, 1.05-2.70; P=0.031) when compared with the T/T + T/C genotype and the wild-type haplotype (TC + TT/T-allele). In the multiple organ dysfunction syndrome (MODS) subgroup, the variant haplotype was also associated with increased severity of sepsis (OR, 2.37; 95%Cl, 1.13-4.94; P=0.02) when compared with the wild haplotype. This association was not significant in male patients. Conclusions The functional polymorphism in exon 5 and the variant haplotype of IRAK1 gene mediate

  18. Community College Periodicals.

    Science.gov (United States)

    Pederson, Eldor O.

    Drawing from an examination of community college periodicals, their availability and characteristics, the academic affiliations of contributing authors, and the topics of their articles, this paper discusses the minor role which community college periodicals appear to play. A list of 35 periodicals dealing primary with community college education…

  19. Few period quasisymmetric stellarators

    Energy Technology Data Exchange (ETDEWEB)

    Isaev, M.Y.; Mikhailov, M.I.; Shafranov, V.D.; Subbotin, A.A. [Russian Research Centre `Kurchatov Institute`, Moscow (Russian Federation); Cooper, W.A. [Ecole Polytechnique Federale, Lausanne (Switzerland). Centre de Recherche en Physique des Plasma (CRPP); Medvedev, S.Y. [Keldysh Inst. of Applied Mathematics, Russian Academy of Sciences, Moscow (Russian Federation)

    1997-06-01

    The results of plasma equilibrium and local stability investigations in two and four-period quasisymmetric stellarators are presented. A near-axis approximation is used for 2-period systems and the 3D codes VMEC and TERPSICHORE are used for four-periods devices to optimise the configurations. (author) 4 figs., 8 refs.

  20. The Periodic Pyramid

    Science.gov (United States)

    Hennigan, Jennifer N.; Grubbs, W. Tandy

    2013-01-01

    The chemical elements present in the modern periodic table are arranged in terms of atomic numbers and chemical periodicity. Periodicity arises from quantum mechanical limitations on how many electrons can occupy various shells and subshells of an atom. The shell model of the atom predicts that a maximum of 2, 8, 18, and 32 electrons can occupy…

  1. 新时期影响残疾大学生就业的因素及对策%The Factors Influencing the Employment of Disabled Col-lege Students and the Solution in the New Period

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

      本文以新时期残疾大学生就业情况为研究对象,重点分析社会需求与自我职业定位的矛盾、职业能力欠佳、不良的就业心理三个影响残疾大学生就业的不利因素,提出高校尤其是各特殊教育高职院校必须要加强职业指导、技能培训,抓住新兴就业热点,建立工作室制度和积极参与政府项目等对策,切实帮助残疾大学生顺利就业。%The paper chooses employment status of disabled col-lege students in the new period as case study. Emphasizes three harmful factors to employment of disabled college students: the contradiction between social needs and personal occupation fixed position, lack of vocational ability, unhealthy employment psy-chology. In order to help them to get a good job, colleges and uni-versities, especially higher vocational schools of special education need to enhance employment guidance, grip the new employment hot spot, set up studio system and join government projects ac-tively.

  2. The incidence of varicella and herpes zoster in Massachusetts as measured by the Behavioral Risk Factor Surveillance System (BRFSS during a period of increasing varicella vaccine coverage, 1998–2003

    Directory of Open Access Journals (Sweden)

    Clements Karen M

    2005-06-01

    Full Text Available Abstract Background The authors sought to monitor the impact of widespread varicella vaccination on the epidemiology of varicella and herpes zoster. While varicella incidence would be expected to decrease, mathematical models predict an initial increase in herpes zoster incidence if re-exposure to varicella protects against reactivation of the varicella zoster virus. Methods In 1998–2003, as varicella vaccine uptake increased, incidence of varicella and herpes zoster in Massachusetts was monitored using the random-digit-dial Behavioral Risk Factor Surveillance System. Results Between 1998 and 2003, varicella incidence declined from 16.5/1,000 to 3.5/1,000 (79% overall with ≥66% decreases for all age groups except adults (27% decrease. Age-standardized estimates of overall herpes zoster occurrence increased from 2.77/1,000 to 5.25/1,000 (90% in the period 1999–2003, and the trend in both crude and adjusted rates was highly significant (p Conclusion As varicella vaccine coverage in children increased, the incidence of varicella decreased and the occurrence of herpes zoster increased. If the observed increase in herpes zoster incidence is real, widespread vaccination of children is only one of several possible explanations. Further studies are needed to understand secular trends in herpes zoster before and after use of varicella vaccine in the United States and other countries.

  3. Even in pneumococcal sepsis CD62L shedding on granulocytes proves to be a reliable functional test for the diagnosis of interleukin-1 receptor-associated kinase-4 deficiency.

    Science.gov (United States)

    Andres, Oliver; Strehl, Karoline; Kölsch, Uwe; Kunzmann, Steffen; Lebrun, Anne-Hélène; Stroh, Thorsten; Schwarz, Klaus; Morbach, Henner; von Bernuth, Horst; Liese, Johannes; Liefse, Johannes

    2013-09-01

    A 9-month-old infant presented with fatal pneumococcal sepsis and attenuated inflammation indices. Even in septic conditions, flow cytometry-based CD62L shedding test on granulocytes proved to be a fast and reliable diagnostic tool for the detection of a defect in the innate immunity. Confirmatory immunologic and genetic assays identified an autosomal-recessive interleukin-1 receptor-associated kinase-4 deficiency due to compound heterozygous mutations.

  4. Effects of tris(1,3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Chunsheng, E-mail: liuchunshengidid@126.com [State Key Laboratory of Pollution Control and Resource Reuse and School of the Environment, Nanjing University, Nanjing (China); Wang, Qiangwei [State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072 (China); Liang, Kang; Liu, Jingfu [State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085 (China); Zhou, Bingsheng [State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072 (China); Zhang, Xiaowei; Liu, Hongling [State Key Laboratory of Pollution Control and Resource Reuse and School of the Environment, Nanjing University, Nanjing (China); Giesy, John P. [Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B3 (Canada); Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5B3 (Canada); Zoology Department, Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States); Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong (China); Yu, Hongxia, E-mail: yuhx@nju.edu.cn [State Key Laboratory of Pollution Control and Resource Reuse and School of the Environment, Nanjing University, Nanjing (China)

    2013-03-15

    Highlights: ► TDCPP or TPP exposure caused developmental toxicity. ► Receptor-centered PCR array was developed. ► TDCPP or TPP exposure altered mRNA expression in receptor-centered network. -- Abstract: Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) are frequently detected in biota, including fish. However, knowledge of the toxicological and molecular effects of these currently used flame retardants is limited. In the present study, an in vivo screening approach was developed to evaluate effects of TDCPP and TPP on developmental endpoints and receptor-associated expression of mRNA in zebrafish embryos/larvae. Exposure to TDCPP or TPP resulted in significantly smaller rates of hatching and survival, in dose- and time-dependent manners. The median lethal concentration (LC{sub 50}) was 7.0 mg/L for TDCPP and 29.6 mg/L for TPP at 120 hour post-fertilization (hpf). Real-time PCR revealed alterations in expression of mRNAs involved in aryl hydrocarbon receptors (AhRs)-, peroxisome proliferator-activated receptor alpha (PPARα)-, estrogenic receptors (ERs)-, thyroid hormone receptor alpha (TRα)-, glucocorticoid receptor (GR)-, and mineralocorticoid receptor (MR)-centered gene networks. Exposure to positive control chemicals significantly altered abundances of mRNA in corresponding receptor-centered gene networks, a result that suggests that it is feasible to use zebrafish embryos/larvae to evaluate effects of chemicals on mRNA expression in these gene networks. Exposure to TDCPP altered transcriptional profiles in all six receptor-centered gene networks, thus exerting multiple toxic effects. TPP was easily metabolized and its potency to change expression of mRNA involved in receptor-centered gene networks was weaker than that of TDCPP. The PPARα- and TRα-centered gene networks might be the primary pathways affected by TPP. Taken together, these results demonstrated that TDCPP and TPP could alter mRNA expression of genes involved in

  5. 泌尿疾病围术期住院患者感染危险因素分析及护理%Risk factors for infections in hospitalized patients with urinary tract diseases during perioperative period and nursing coutermeasures

    Institute of Scientific and Technical Information of China (English)

    黄炳琴

    2012-01-01

    目的 观察泌尿疾病患者围术期感染的危险因素,探讨其护理特点,为临床工作提供支持.方法 应用回顾性研究与前瞻性研究相结合的方法,收集5643例泌尿外科住院患者的相关资料,采用SAS 6.12进行统计分析.结果 共343例患者发生医院感染,感染率为6.28%;医院感染患者的发生率与性别、年龄、留置导管、是否伴糖尿病、恶性肿瘤及住院时间密切相关(P<0.05).结论 泌尿疾病围术期患者应重点监测,加强重点患者的风险监测,同时进行有效的护理干预,可能对减少围术期的感染有重要价值.%OBJECTIVE To observe the risk factors for nosocomial infections in the patients with urinary tract diseases, investigate the nursing characteristics so as to support the clinical treatment. METHODS By means of retrospective study in combination with prospective study, the related data of 5643 patients from department of urology were collected, the statistical analysis was performed by using SAS6. 12. RESULTS Nosocomial infections occurred in totally 343 patients with the infection rate of 6. 28% ; the incidence of nosocomial infections was closely associated with the sex, age, indwelling catheter, diabetes, malignant tumor and hospital stay (P < 0. 05). CONCLUSION It is necessary to focus on the surveillance of the patients with urinary tract diseases during the perioperative period, especially the patients at high risk, meanwhile to carry out the effective nursing interventions so as to reduce the infections during the perioperative period.

  6. Study of factors related to cognitive function in patients withcerebral hemorrhage in recovery period%康复期脑出血患者认知功能的相关因素研究

    Institute of Scientific and Technical Information of China (English)

    戢运建; 况娥

    2016-01-01

    Objective To investigate the factors related to cognitive dysfunction in patients withhypertensive cerebral hemorrhage in recovery period.Methods 128 hypertensive cerebral hemorrhage, from June 2012 to December 2014 in our hospital, were selected for this study.Clinical data such as age, sex, educational level, history of diabetes, smoking and drink-ing history, CT results, blood lipids and high-sensitivity C-reactive protein levels were collected. Neurological recovery of pa-tients was evaluated by the US National Institutes of Health Stroke Scale (NIHSS) at 4 weeks after onset. Cognitive impairment was evaluated byMontreal Cognitive Scale (MoCA). The risk factors of cognitive dysfunction analysised by multiple Logistic regression.Results There were 57 cases with vascular cognitive impairment in 128 hypertensive cerebral hemorrhage, ac-counting for 44.53%. Scores of executive function, memory, language, and disorientation in patients with cognitive impairment were (4.4±0.7), (2.6±1.6), (2.4±0.4), (5.9±0.4), and were significantly higher than those without cognitive impairment pa-tients[(2.9±0.8), (2.0±1.5), (1.9±0.8) , (5.6±0.8)]. Univariate analysis showed that age, education level, regular exercise, dia-betes, lesion side, lesion range, high sensitivity C-reactive protein, homocysteine disease and the scores of NIHSS reduced were related to cognitive impairment in patients withcerebral hemorrhage in recovery period. Logistic regression analysis showed that age, regular physical exercise, high sensitivity C-reactive protein disease and lower NIHSS score were the main factors affect-ing the cognitive dysfunction. Conclusion Aged> 60 years, no regular physical exercise, with high sensitivity C-reactive protein disease and the scores of NIHSS reduced were the main factors related to cognitive dysfunction in patients with hypertensive cerebral hemorrhage in recovery period.%目的:探讨影响康复期高血压脑出血患者发生认知功能障碍的

  7. Factors Associated With Dropout During Recruitment and Follow-Up Periods of a mHealth-Based Randomized Controlled Trial for Mobile.Net to Encourage Treatment Adherence for People With Serious Mental Health Problems

    Science.gov (United States)

    Korhonen, Joonas; Adams, Clive E; Koivunen, Marita Hannele; Vahlberg, Tero; Välimäki, Maritta Anneli

    2017-01-01

    Background Clinical trials are the gold standard of evidence-based practice. Still many papers inadequately report methodology in randomized controlled trials (RCTs), particularly for mHealth interventions for people with serious mental health problems. To ensure robust enough evidence, it is important to understand which study phases are the most vulnerable in the field of mental health care. Objective We mapped the recruitment and the trial follow-up periods of participants to provide a picture of the dropout predictors from a mHealth-based trial. As an example, we used a mHealth-based multicenter RCT, titled “Mobile.Net,” targeted at people with serious mental health problems. Methods Recruitment and follow-up processes of the Mobile.Net trial were monitored and analyzed. Recruitment outcomes were recorded as screened, eligible, consent not asked, refused, and enrolled. Patient engagement was recorded as follow-up outcomes: (1) attrition during short message service (SMS) text message intervention and (2) attrition during the 12-month follow-up period. Multiple regression analysis was used to identify which demographic factors were related to recruitment and retention. Results We recruited 1139 patients during a 15-month period. Of 11,530 people screened, 36.31% (n=4186) were eligible. This eligible group tended to be significantly younger (mean 39.2, SD 13.2 years, P<.001) and more often women (2103/4181, 50.30%) than those who were not eligible (age: mean 43.7, SD 14.6 years; women: 3633/6514, 55.78%). At the point when potential participants were asked to give consent, a further 2278 refused. Those who refused were a little older (mean 40.2, SD 13.9 years) than those who agreed to participate (mean 38.3, SD 12.5 years; t1842=3.2, P<.001). We measured the outcomes after 12 months of the SMS text message intervention. Attrition from the SMS text message intervention was 4.8% (27/563). The patient dropout rate after 12 months was 0.36% (4/1123), as

  8. Periodicity of chaotic solutions

    CERN Document Server

    Berezowski, Marek

    2016-01-01

    The scope of the paper is the analysis of the impact of flow reversal on the dynamics of cascades of reactors. Periodic and chaotic oscillations occur in the analyzed system. There is a dependence between the oscillation period of the state variable of the system without flow reversal and the recurrence period of windows of chaos in the steady-state diagram of the system with flow reversal.

  9. Bott periodicity of inclusions

    CERN Document Server

    Mare, Augustin-Liviu

    2011-01-01

    When looking at Bott's original proof of his periodicity theorem for the stable homotopy groups of the orthogonal and unitary groups, one sees in the background a differential geometric periodicity phenomenon. We show that this geometric phenomenon extends to the standard inclusion of the orthogonal group into the unitary group. This explains the periodicity of the group homomorphisms between stable homotopy groups which are induced by the inclusion map. Standard inclusions between other classical Riemannian symmetric spaces are also discussed.

  10. Study on the Changes in Enzyme and Insulin-like Growth Factor-1 Concentrations in Blood Serum and Growth Characteristics of Velvet Antler during the Antler Growth Period in Sika Deer (

    Directory of Open Access Journals (Sweden)

    Jaehyun Park

    2015-09-01

    Full Text Available This study was conducted to investigate changes in blood enzyme parameters and to evaluate the relationship between insulin-like growth factor-1 (IGF-1, antler growth and body weight during the antler growth of sika deer (Cervus nippon. Serum enzyme activity and IGF-1 concentrations were measured in blood samples collected from the jugular and femoral veins at regular intervals during the antler growth period. Blood samples were taken in the morning from fasted stags (n = 12 which were healthy and showed no clinical signs of disease. Alfalfa was available ad libitum and concentrates were given at 1% of body weight to all stags. The experimental diet was provided at 9 am with water available at all times. There were no significant differences in alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase during antler growth, but alkaline phosphatase concentrations increased with antler growth progression, and the highest alkaline phosphatase concentration was obtained 55 days after antler casting. Serum IGF-1 concentrations measured from blood samples taken from the jugular vein during antler growth, determined that levels of IGF-1 was associated with body weight and antler growth patterns. Serum IGF-1 concentrations were higher at the antler cutting date than other sampling dates. Antler length increased significantly during antler growth (p<0.001, and there was a similar trend to between right and left beams. Body weight increased with antler growth but was not significant. Consequently it appeared that serum alkaline phosphatase concentration was related to antler growth and both antler growth and body weight were associated positively with IGF-1 concentrations during antler growth.

  11. Insulin-like growth factor I (IGF-I) in Chinese alligator, Alligator sinensis: Molecular characterization, tissue distribution and mRNA expression changes during the active and hibernating periods.

    Science.gov (United States)

    Zhu, Xue; Zhang, Shengzhou; Zhao, Shuai; Zhang, Rui; Zhou, Yongkang; Wu, Xiaobing

    2017-02-01

    The Chinese alligator Alligator sinensis is an endangered species endemic to China, up to date, little is known about the regulation of its growth and development. Insulin-like growth factor I (IGF-I) plays a vital role in regulating vertebrate growth and development. In this study, the full-length cDNA of IGF-I in Chinese alligator (caIGF-I) was obtained for the first time, it contains 890-bp nucleotides encoding a 153-amino acid precursor, the mature caIGF-I consists of 70 amino acids by cleaving the signal peptide and C-terminal extension (E domain). The caIGF-I contains all the features of IGF-I peptide with B, C, A, and D domains and the six conservative cysteine residues involved in the stable tertiary structure. Multiple alignment analysis showed that the amino acid sequence of caIGF-I shares high identity with American alligator Alligator mississippiensis (100%) and birds (95-97%). Phylogenetic tree analysis of the IGF-I amino acid sequences indicated that alligators cluster into the bird branch. Real-time quantitative PCR technique showed that caIGF-I is widely expressed in all the examined tissues with the highest expression level in liver, higher in pancreas and oviduct while lower in heart, spleen, lung, kidney, stomach, intestines, ovary and muscles. During hibernation, the caIGF-I expression level decreased significantly in liver, pancreas, oviduct and kidney, while did not significantly change in heart, spleen, lung, stomach, small intestine, ovary and muscles. The mRNA expression changes during the two periods implicate that caIGF-I might play an important role in the regulation of feeding and growth in the Chinese alligator.

  12. Painful menstrual periods

    Science.gov (United States)

    Menstruation - painful; Dysmenorrhea; Periods - painful; Cramps - menstrual; Menstrual cramps ... related activities for a few days during each menstrual cycle. Painful menstruation is the leading cause of ...

  13. Hypokalemic periodic paralysis

    National Research Council Canada - National Science Library

    Abbas, Haider; Kothari, Nikhil; Bogra, Jaishri

    2012-01-01

    Hypokalemic periodic paralysis is a rare genetic disorder characterized by recurrent attacks of skeletal muscle weakness with associated hypokalemia which is precipitated by stress, cold, carbohydrate...

  14. Research on Influencing Factors of Financial Restatement -- Based on the Analysis of Pre-Error Period and Post-Restatement Period%财务重述影响因素研究——基于差错发生期和差错更正期的分析

    Institute of Scientific and Technical Information of China (English)

    马晨; 张俊瑞; 李彬

    2012-01-01

    Studying items of accounting errors correction from annual report in Chinese Listed firms in A share market between 2002-2010, based on the analysis of pre-error period and post-restatement period of financial restatement, this research systematically investigates the influencing factors of financial restatement with logit regression, taking financial restatement occurs or not as depen- dent variable. The finding suggests that, in terms of financial ratio, higher free cash flow and current ratio lead to lower likelihood of accounting misstatement and restatement; there is no significant relationship between firm growth and accounting misstatement and re- statement. In terms of internal governance, firms with big board size are likely to misstate, board size has no significant effect on re- statement; when CEO- chairman role is not splitted, firms have a lower likelihood of restatement, and duality is not significantly relat- ed to misstatement; firms with smaller frequency of board meeting, higher board shareholding and ownership concentration, have a low- er likelihood of accounting misstate ment and restatement. In terms of external audit, firms with auditor change and qualified audit opinion, audited by non-Big 4 are more likely to misstate and restate. This research develops the contents of financial restatement re- search, providing empirical evidence and suggestions for regulatory authorities, to prevent accounting errors and financial restatement.%以2002~2010年我国A股上市公司年报中出现"前期会计差错更正"项目的公司为研究对象,基于财务重述差错发生期和差错更正期的分析,以是否发生财务重述为因变量,利用logit回归系统,考察了财务重述的影响因素。在财务指标方面,自由现金流越大,流动比率越高,公司发生会计差错和更正会计差错的概率就越小,公司增长速度与会计差错的发生和更正之间不存在显著关系。在内部治理方面,董事会规

  15. Second Period Access Report

    DEFF Research Database (Denmark)

    Maisondieu, Christophe; Giebhardt, Jochen; Tetu, Amelie

    The work described in this publication has received support from the European Community - Research Infrastructure Action under the FP7 “Capacities” Specific Programme through grant agreement number 262552, MaRINET. Project Periodic Report. 2nd Period: October 2012 – March 2014 inclusive....

  16. The Living Periodic Table

    Science.gov (United States)

    Nahlik, Mary Schrodt

    2005-01-01

    To help make the abstract world of chemistry more concrete eighth-grade students, the author has them create a living periodic table that can be displayed in the classroom or hallway. This display includes information about the elements arranged in the traditional periodic table format, but also includes visual real-world representations of the…

  17. Latent Period of Relaxation.

    Science.gov (United States)

    Kobayashi, M; Irisawa, H

    1961-10-27

    The latent period of relaxation of molluscan myocardium due to anodal current is much longer than that of contraction. Although the rate and the grade of relaxation are intimately related to both the stimulus condition and the muscle tension, the latent period of relaxation remains constant, except when the temperature of the bathing fluid is changed.

  18. On some periodicity effects

    DEFF Research Database (Denmark)

    Sorokin, Sergey V.

    2015-01-01

    The talk is concerned with the modelling of wave propagation in and vibration of periodic elastic structures. Although analysis of wave-guide properties of infinite periodic structures is a well establish research subject, some issues have not yet been fully addressed in the literature. The aim o...

  19. The Living Periodic Table

    Science.gov (United States)

    Nahlik, Mary Schrodt

    2005-01-01

    To help make the abstract world of chemistry more concrete eighth-grade students, the author has them create a living periodic table that can be displayed in the classroom or hallway. This display includes information about the elements arranged in the traditional periodic table format, but also includes visual real-world representations of the…

  20. Periodic Time Series Models

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); R. Paap (Richard)

    2004-01-01

    textabstractThis book considers periodic time series models for seasonal data, characterized by parameters that differ across the seasons, and focuses on their usefulness for out-of-sample forecasting. Providing an up-to-date survey of the recent developments in periodic time series, the book

  1. Periods and Nori motives

    CERN Document Server

    Huber, Annette

    2017-01-01

    This book casts the theory of periods of algebraic varieties in the natural setting of Madhav Nori’s abelian category of mixed motives. It develops Nori’s approach to mixed motives from scratch, thereby filling an important gap in the literature, and then explains the connection of mixed motives to periods, including a detailed account of the theory of period numbers in the sense of Kontsevich-Zagier and their structural properties. Period numbers are central to number theory and algebraic geometry, and also play an important role in other fields such as mathematical physics. There are long-standing conjectures about their transcendence properties, best understood in the language of cohomology of algebraic varieties or, more generally, motives. Readers of this book will discover that Nori’s unconditional construction of an abelian category of motives (over fields embeddable into the complex numbers) is particularly well suited for this purpose. Notably, Kontsevich's formal period algebra represents a to...

  2. Mean-periodic functions

    Directory of Open Access Journals (Sweden)

    Carlos A. Berenstein

    1980-01-01

    Full Text Available We show that any mean-periodic function f can be represented in terms of exponential-polynomial solutions of the same convolution equation f satisfies, i.e., u∗f=0(μ∈E′(ℝn. This extends to n-variables the work of L. Schwartz on mean-periodicity and also extends L. Ehrenpreis' work on partial differential equations with constant coefficients to arbitrary convolutors. We also answer a number of open questions about mean-periodic functions of one variable. The basic ingredient is our work on interpolation by entire functions in one and several complex variables.

  3. 经济转轨期中国企业成长的影响因素及其机理分析%An Analysis on the Influencing Factor and Influence Mechanism of Chinese Enterprise Growth in Economic Transition Period

    Institute of Scientific and Technical Information of China (English)

    杜传忠; 郭树龙

    2012-01-01

    本文基于2005年世界银行企业投资环境调查的大样本数据,运用分位数回归方法研究了中国经济转轨期企业成长问题,重点考察了渐进式经济转轨特征对企业成长的影响。研究结果表明。国有经济、政府税收、市场竞争、融资约束等转轨特征是制约企业成长的重要因素,FDI、出口、R&D、员工教育和职业培训等显著促进了企业的成长。进一步细分不同企业规模的估计结果表明,政府税收、地方保护和市场竞争对中小企业成长的制约作用显著高于对大企业的影响,而R&D和职业培训则显著促进了中小企业的成长。%This paper is based on the large sample date of the Word Bank Business Environment Survey, using the quantile regression method to study enterprise growth in period of Chinese economic transition, mainly investigates the influence of the characteristics of gradual economic transformation on enterprise growth. The results show that the transition characteristics of state-owned economy, government tax, market competition, financing constraints, and so on are the important factors of restricted enterprise growth, FDI, export, R&D, employee educational background and professional training significantly promote enterprise growth. The estimation results of further separating different enterprise sizes show that the restrictive effects of government tax, local protection and market competition on the SMEs growth are significantly higher than large enterprises, while R&D intensity and professional training significantly promote SMEs growth.

  4. Risk factors associated with insomnia in recovery period of ischemic stroke%缺血性卒中恢复期伴失眠的危险因素研究

    Institute of Scientific and Technical Information of China (English)

    李婉仪; 陈仰昆; 李伟; 袁伟杰; 翁汉育; 刘勇林; 屈剑锋; 林显仙; 肖卫民

    2015-01-01

    Objective To investigate the clinical and psychological risk factors of insomnia during recovery period of ische‐mic stroke .Methods A total of 225 patients with acute ischemic stroke participated in this study .All participants received in‐somnia and neuropsychological assessments at 3 months after stroke .Insomnia symptoms were evaluated using a standard in‐somnia questionnaire .Depressive and anxious symptoms were measured by the Hamilton Depression Scales(HDS)and Hamil‐ton Anxiety Scales(HAS) .Clinical and neuropsychological variables were compared between the insomnia and non‐insomnia group .Logistic regression was performed to find the related factors of insomnia .Results Sixty‐seven (29 .8% )patients had in‐somnia .Compared with non‐insomnia cases ,patients with insomnia had significantly higher NIHSS scores and HDS scores on admission (P<0 .05) .Insomnia was more common in insomnia subjects before stroke(52 .2% vs .12 .7% ,P<0 .001) .Logis‐tic regression analysis showed that insomnia before stroke (OR=2 .729 ,95% CI=1 .550‐4 .804 , P= 0 .001) and the HDS score (OR=1 .240 ,95% CI=1 .158‐1 .327 , P<0 .001) were significantly related to insomnia at recovery stage of ischemic stroke .Conclusion Insomnia is common at recovery stage of ischemic stroke .Pre‐stroke insomnia and severity of post‐stroke depressive symptoms are the major determinants of insomnia .%目的:探讨缺血性脑卒中患者恢复期伴失眠的临床及神经心理学危险因素。方法纳入225例急性缺血性脑卒中患者,在卒中后3个月进行失眠及神经心理学评估。失眠的评估采用标准的失眠问卷,抑郁症状评估采用汉密尔顿抑郁量表(HDS),焦虑症状评估采用汉密尔顿焦虑量表(HAS)。比较失眠及非失眠2组间的临床及神经心理学指标,应用Logis‐tic回归分析失眠的影响因素。结果67例(29.8%)存在失眠。失眠患者入院NIHSS评分及 HDS评

  5. Setting the Periodic Table.

    Science.gov (United States)

    Saturnelli, Annette

    1985-01-01

    Examines problems resulting from different forms of the periodic table, indicating that New York State schools use a form reflecting the International Union of Pure and Applied Chemistry's 1984 recommendations. Other formats used and reasons for standardization are discussed. (DH)

  6. The Periodic Table CD.

    Science.gov (United States)

    Banks, Alton J.; Holmes, Jon L.

    1995-01-01

    Describes the characteristics of the digitized version of The Periodic Table Videodisc. Provides details about the organization of information and access to the data via Macintosh and Windows computers. (DDR)

  7. Familial Periodic Paralyses

    Science.gov (United States)

    ... and less severe than the hypokalemic form. Muscle spasms are common. × Definition Familial periodic paralyses are a ... and less severe than the hypokalemic form. Muscle spasms are common. View Full Definition Treatment Treatment of ...

  8. Extremal periodic wave profiles

    Directory of Open Access Journals (Sweden)

    E. van Groesen

    2007-01-01

    Full Text Available As a contribution to deterministic investigations into extreme fluid surface waves, in this paper wave profiles of prescribed period that have maximal crest height will be investigated. As constraints the values of the momentum and energy integrals are used in a simplified description with the KdV model. The result is that at the boundary of the feasible region in the momentum-energy plane, the only possible profiles are the well known cnoidal wave profiles. Inside the feasible region the extremal profiles of maximal crest height are "cornered" cnoidal profiles: cnoidal profiles of larger period, cut-off and periodically continued with the prescribed period so that at the maximal crest height a corner results.

  9. On semi-periods

    CERN Document Server

    Avram, A C; Jancic, D; Uni, H; Uni, Humboldt

    1995-01-01

    The periods of the three-form on a Calabi-Yau manifold are found as solutions of the Picard-Fuchs equations; however, the toric varietal method leads to a generalized hypergeometric system of equations which has more solutions than just the periods. This same extended set of equations can be derived from symmetry considerations. Semi-periods are solutions of this extended system. They are obtained by integration of the three-form over chains; these chains can be used to construct cycles which, when integrated over, give periods. In simple examples we are able to obtain the complete set of solutions for the extended system. We also conjecture that a certain modification of the method will generate the full space of solutions in general.

  10. Setting the Periodic Table.

    Science.gov (United States)

    Saturnelli, Annette

    1985-01-01

    Examines problems resulting from different forms of the periodic table, indicating that New York State schools use a form reflecting the International Union of Pure and Applied Chemistry's 1984 recommendations. Other formats used and reasons for standardization are discussed. (DH)

  11. The Periodic Table CD.

    Science.gov (United States)

    Banks, Alton J.; Holmes, Jon L.

    1995-01-01

    Describes the characteristics of the digitized version of The Periodic Table Videodisc. Provides details about the organization of information and access to the data via Macintosh and Windows computers. (DDR)

  12. Optimal periodic control

    CERN Document Server

    Colonius, Fritz

    1988-01-01

    This research monograph deals with optimal periodic control problems for systems governed by ordinary and functional differential equations of retarded type. Particular attention is given to the problem of local properness, i.e. whether system performance can be improved by introducing periodic motions. Using either Ekeland's Variational Principle or optimization theory in Banach spaces, necessary optimality conditions are proved. In particular, complete proofs of second-order conditions are included and the result is used for various versions of the optimal periodic control problem. Furthermore a scenario for local properness (related to Hopf bifurcation) is drawn up, giving hints as to where to look for optimal periodic solutions. The book provides mathematically rigorous proofs for results which are potentially of importance in chemical engineering and aerospace engineering.

  13. Hyperkalemic periodic paralysis

    Science.gov (United States)

    ... Rott K, Rudel R, Lehmann-Horn F. Muscle channelopathies: myotonias and periodic paralyses. In: Darras BT, Jones ... Elsevier; 2015:chap 38. Kerchner GA, Ptacek LJ. Channelopathies: episodic and electrical disorders of nervous system. In: ...

  14. Hypokalemic periodic paralysis

    Science.gov (United States)

    ... Rott K, Rudel R, Lehmann-Horn F. Muscle channelopathies: myotor and periodic paralyses. In: Darras BT, Jones ... Elsevier; 2015:chap 38. Kerchner GA, Ptacek LJ. Channelopathies. In: Daroff RB, Jankovic J, Mazziotta JC, Pomeroy ...

  15. Correlation factor analysis of mental stress reaction of patients during acute burn period%烧伤急性期患者心理应激反应的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    吴孝苹; 王东; 宋中金; 孙充洲; 胥云霞; 肖晓兰; 何友德; 孙学礼

    2006-01-01

    depressive patients during acute burn period, which were higher than those in normal group (4.29±2.26, 5.48±2.06, P=0.01). ② The main influential factor for depression were burning area and social supporting availability, and those for anxiety were age, burning area, social supporting availability and subjective social supporting degree. ③ MMPI test results show that T scores in anxiety-depression group were below 60 points, however T-scores were above 60 points in normal group including cheating points, hypomania,schizophrenia, psychasthenia and paranoid ideation CONCLUSION: Burn is a mental crisis to burn patients, which can lead to abnormal emotional reaction and personality change. The depressive and anxious score are positively related with burning area, and are negatively correlated with society supporting availability. The good social support system is benefit to over mental crisis period.%背景:烧伤是一种心身创伤,烧伤后的心理创伤反应的强弱与个性、个人经历、社会支持可能有关.目的:调查急性期烧伤患者的心理应激反应、社会支持程度、明尼苏达多相人格特点,分析心理应激反应的影响因素.设计:横断面调查.单位:四川大学华西精神卫生中心,绵阳市中心医院烧伤科,攀枝花钢铁公司总医院烧伤科.对象:选择2003-04/2005-04绵阳市中心医院、攀钢总医院烧伤专科的住院患者104例,均为轻、中、重度热力烧伤,男92例,女12例;年龄12~60岁.方法:于烧伤后3 d内进行量表评定,包括汉密顿抑郁量表、汉密顿焦虑量表、明尼苏达多相人格调查表、社会支持评定量表及临床一般资料.按汉密顿抑郁量表、汉密顿焦虑量表的分值(焦虑>7分,抑郁>8分是焦虑抑郁情绪),分为有焦虑抑郁情绪组51例和正常情绪组53例.以汉密顿焦虑量表和汉密顿抑郁量表得分为因变量,进行逐步回归分析,筛选出影响患者焦虑和抑郁的主要因素.主要观

  16. Historically defined autobiographical periods

    DEFF Research Database (Denmark)

    Brown, Norman R.; Hansen, Tia G. B.; Lee, Peter J.;

    2012-01-01

    The chapter reviews a research programme that has demonstrated the existence of historically defined autobiographical periods and identified the conditions that bring them about. Data from four samples of World War II-generation adults show that historically defined autobiographical periods endure...... over time and theoretical implications are discussed, notably by introducing a new approach to autobiographical memory, Transition Theory, which assumes that autobiographical memory is organized by transitional events that can be selfinitiated or externally imposed - historically defined...

  17. Diagnostic and Predictive Levels of Calcium-binding Protein A8 and Tumor Necrosis Factor Receptor-associated Factor 6 in Sepsis-associated Encephalopathy: A Prospective Observational Study

    Directory of Open Access Journals (Sweden)

    Li-Na Zhang

    2016-01-01

    Conclusions: Peripheral blood levels of S100A8 and TRAF6 in SAE patients were elevated and might be related to the severity of SAE and predict the outcome of SAE. The efficacy and specificity of S100A8 for SAE diagnosis were superior, despite its weak sensitivity. S100A8 might be a better biomarker for diagnosis of SAE and predicting prognosis.

  18. Treatment for periodic paralysis.

    Science.gov (United States)

    Sansone, V; Meola, G; Links, T P; Panzeri, M; Rose, M R

    2008-01-23

    Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. The objective of this review was to systematically review treatment of periodic paralyses. We searched the Cochrane Neuromuscular Disease Group Trials Register, MEDLINE (from January 1966 to July 2007), and EMBASE (from January 1980 to July 2007) and any other available international medical library sources from the University of Milan for randomised trials. We included randomised (including cross-over studies) and quasi-randomised trials in participants with primary periodic paralyses, in which any form of treatment, including physical therapy and alternative therapies, was compared to placebo or another treatment. Our primary outcome measure was the change in attack severity or frequency by eight weeks from the start of treatment. Our secondary outcome measures were: change in muscle strength and mass; change in Quality of Life, using Short Form 36 (SF36) or similar; preference of treatment strategy; adverse effects at eight weeks. Three studies met our inclusion criteria. In one study dichlorphenamide (DCP) vs placebo was tested in two groups of participants: 42 with hypokalemic periodic paralysis (HypoPP) and 31 with hyperkalemic periodic paralysis (HyperPP), based on clinical criteria. Thirty-four of 42 participants with hypokalemic periodic paralysis completed both treatment phases. For the 34 participants having attack rate data for both treatment phases, the mean improvement in attack rate (P = 0.02) and severity-weighted attack rate (P = 0.01) on DCP relative to placebo were statistically significant. Fifteen preferred DCP, three placebo and six their baseline medication. Twenty-four of 31 participants with hyperkalemic periodic paralysis completed both treatment phases: for the 16 participants who had attack rate data for both

  19. Thyrotoxic periodic paralysis

    Directory of Open Access Journals (Sweden)

    Rojith Karandode Balakrishnan

    2011-01-01

    Full Text Available This article aims at highlighting the importance of suspecting thyrotoxicosis in cases of recurrent periodic flaccid paralysis; especially in Asian men to facilitate early diagnosis of the former condition. A case report of a 28 year old male patient with recurrent periodic flaccid paralysis has been presented. Hypokalemia secondary to thyrotoxicosis was diagnosed as the cause of the paralysis. The patient was given oral potassium intervention over 24 hours. The patient showed complete recovery after the medical intervention and was discharged after 24 hours with no residual paralysis. Thyrotoxic periodic paralysis (TPP is a complication of thyrotoxicosis, more common amongst males in Asia. It presents as acute flaccid paralysis in a case of hyperthyroidism with associated hypokalemia. The features of thyrotoxicosis may be subtle or absent. Thus, in cases of recurrent or acute flaccid muscle paralysis, it is important to consider thyrotoxicosis as one of the possible causes, and take measures accordingly.

  20. Hyperthyroid hypokalemic periodic paralysis.

    Science.gov (United States)

    Neki, N S

    2016-01-01

    Hyperthyroid periodic paralysis (HPP) is a rare life threatening complication of hyperthyroidism commonly occurring in young Asian males but sporadically found in other races. It is characterised by hypokalemia and acute onset paraparesis with prevalence of one in one hundred thousand (1 in 100000). The symptoms resolve promptly with potassium supplementation. Nonselective beta blockers like propranol can also be used to ameliorate and prevent subsequent paralytic attack. We report a case of 22 year old male presenting with hyperthyroid periodic paralysis (HPP) having very low serum potassium level.

  1. Fatores de risco associados à hospitalização por bronquiolite aguda no período pós-neonatal Risk factors associated with hospitalization for bronchiolitis in the post-neonatal period

    Directory of Open Access Journals (Sweden)

    Elaine P Albernaz

    2003-08-01

    Full Text Available OBJETIVO: Investigar a relação entre fatores socioeconômicos, características maternas, aleitamento e hospitalização por bronquiolite no período pós-neonatal. MÉTODOS: Estudo caso-controle, aninhado a estudo de coorte de 5.304 crianças nascidas na cidade de Pelotas, RS. O estudo de coorte constitui-se de quatro subestudos, cada um com métodos e logística específicos. As mães foram entrevistadas por meio de questionário padronizado, em visitas hospitalares e domiciliares. Foram definidos como casos as crianças com idade entre 28 e 364 dias, que haviam sido hospitalizadas por bronquiolite. RESULTADOS: De 5.304 crianças da coorte, 113 (2,1% foram hospitalizadas por bronquiolite. A análise multivariada hierarquizada, realizada pela regressão logística, mostrou os seguintes resultados: renda familiar, assim como idade gestacional, estiveram inversamente relacionadas ao risco de hospitalização por bronquiolite. O aleitamento materno desempenhou um fator protetor; crianças com tempo de aleitamento materno inferior a um mês tiveram risco 7 vezes maior de serem hospitalizadas por bronquiolite aguda nos primeiros três meses de vida. O risco de hospitalização por bronquiolite foi 57% maior naquelas expostas ao fumo materno. CONCLUSÕES: A hospitalização por bronquiolite está inversamente relacionada com renda familiar, idade gestacional e tempo de aleitamento materno, e diretamente relacionada com exposição a fumo materno. Não foi evidenciada associação com paridade ou história materna de asma brônquica.OBJECTIVE: To investigate the relationship between socioeconomic factors, maternal characteristics, breastfeeding, and hospitalization for bronchiolitis in the post-neonatal period. METHODS: A nested case-control study with a cohort of 5,304 children born in the city of Pelotas, Brazil, was conducted. The cohort study consisted of four sub-studies with their own methods and logistics. Mothers were interviewed using a

  2. Analysis on dietary survey and influencing factors of wet nurses during puerperal period%乳母产褥期膳食调查与影响因素分析

    Institute of Scientific and Technical Information of China (English)

    李国波; 林麒; 欧萍; 许榕仙; 葛品

    2015-01-01

    Objective:To understand the lifestyles and dietary structure of wet nurses in Fuzhou region and the interrelationship.Methods:A survey about lifestyles,nutritional and healthy conditions was conducted among the healthy wet nurses meeting the inclusion criteria and living in Fuzhou for one year or more than one year.Results:A total of 113 valid questionnaires were collected,the average daily intakes of poultry meat and eggs of wet nurses during puerperal period accounted for 439.5% and 350.0% of dietary reference intakes (DRIs) of wet nurses,respectively; fruits and vegetables accounted for 43.3% and 25.0% of DRIs of wet nurses,respectively; milk,milk products,beans,and bean products accounted for 0.0% of DRIs of wet nurses,respectively.The average daily intake of energy accounted for 78.5% of RNIs of wet nurses; the proportion of energy supplied by carbohydrate was low (34.3%),and the proportions of energy supplied by protein (27.9%) and fat (37.0%) were high.The average daily intakes of calcium and vitamin C accounted for 45.4% and 73.8% of RNI or AI of wet nurses,no calcium was from milk and beans.The intake and intake proportion of iron from grains among the exclusive breastfeeding nurses were less than those among the nonexclusive breastfeeding nurses; the intakes of fruits,iron,manganese,vitamin C,and carbohydrate among the wet nurses with history of drinking tea were higher than those among the wet nurses without history of drinking tea.Conclusion:The intakes of poultry meat and eggs of wet nurses during puerperal period are adequate even excess,but the intakes of vegetables,milk,milk products,beans,and bean products are extremely low,the intake of fruits is inadequate.The intake of total energy is inadequate,the energy proportions supplied by three nutriments are unreasonable,dietary structure of wet nurses are correlated with social factor.%目的:了解福州地区乳母产褥期生活方式、膳食结构及其之间

  3. Hereditary periodic fever syndromes

    NARCIS (Netherlands)

    McDermott, MF; Frenkel, J

    Hereditary periodic fever syndromes are defined by recurrent attacks of generalised inflammation for which no infectious or auto-immune cause can be identified. For most of these disorders, the molecular basis has recently been elucidated. This has opened the prospect of novel therapeutic

  4. Periodic Table of Students.

    Science.gov (United States)

    Johnson, Mike

    1998-01-01

    Presents an exercise in which an eighth-grade science teacher decorated the classroom with a periodic table of students. Student photographs were arranged according to similarities into vertical columns. Students were each assigned an atomic number according to their placement in the table. The table is then used to teach students about…

  5. A Modern Periodic Table.

    Science.gov (United States)

    Herrenden-Harker, B. D.

    1997-01-01

    Presents a modern Periodic Table based on the electron distribution in the outermost shell and the order of filling of the sublevels within the shells. Enables a student to read off directly the electronic configuration of the element and the order in which filling occurs. (JRH)

  6. Oscillations following periodic reinforcement.

    Science.gov (United States)

    Monteiro, Tiago; Machado, Armando

    2009-06-01

    Three experiments examined behavior in extinction following periodic reinforcement. During the first phase of Experiment 1, four groups of pigeons were exposed to fixed interval (FI 16s or FI 48s) or variable interval (VI 16s or VI 48s) reinforcement schedules. Next, during the second phase, each session started with reinforcement trials and ended with an extinction segment. Experiment 2 was similar except that the extinction segment was considerably longer. Experiment 3 replaced the FI schedules with a peak procedure, with FI trials interspersed with non-food peak interval (PI) trials that were four times longer. One group of pigeons was exposed to FI 20s PI 80s trials, and another to FI 40s PI 160s trials. Results showed that, during the extinction segment, most pigeons trained with FI schedules, but not with VI schedules, displayed pause-peck oscillations with a period close to, but slightly greater than the FI parameter. These oscillations did not start immediately after the onset of extinction. Comparing the oscillations from Experiments 1 and 2 suggested that the alternation of reconditioning and re-extinction increases the reliability and earlier onset of the oscillations. In Experiment 3 the pigeons exhibited well-defined pause-peck cycles since the onset of extinction. These cycles had periods close to twice the value of the FI and lasted for long intervals of time. We discuss some hypotheses concerning the processes underlying behavioral oscillations following periodic reinforcement.

  7. Periodically poled silicon

    Science.gov (United States)

    Hon, Nick K.; Tsia, Kevin K.; Solli, Daniel R.; Khurgin, Jacob B.; Jalali, Bahram

    2010-02-01

    Bulk centrosymmetric silicon lacks second-order optical nonlinearity χ(2) - a foundational component of nonlinear optics. Here, we propose a new class of photonic device which enables χ(2) as well as quasi-phase matching based on periodic stress fields in silicon - periodically-poled silicon (PePSi). This concept adds the periodic poling capability to silicon photonics, and allows the excellent crystal quality and advanced manufacturing capabilities of silicon to be harnessed for devices based on χ(2)) effects. The concept can also be simply achieved by having periodic arrangement of stressed thin films along a silicon waveguide. As an example of the utility, we present simulations showing that mid-wave infrared radiation can be efficiently generated through difference frequency generation from near-infrared with a conversion efficiency of 50% based on χ(2) values measurements for strained silicon reported in the literature [Jacobson et al. Nature 441, 199 (2006)]. The use of PePSi for frequency conversion can also be extended to terahertz generation. With integrated piezoelectric material, dynamically control of χ(2)nonlinearity in PePSi waveguide may also be achieved. The successful realization of PePSi based devices depends on the strength of the stress induced χ(2) in silicon. Presently, there exists a significant discrepancy in the literature between the theoretical and experimentally measured values. We present a simple theoretical model that produces result consistent with prior theoretical works and use this model to identify possible reasons for this discrepancy.

  8. Treatment for periodic paralysis

    NARCIS (Netherlands)

    Sansone, [No Value; Meola, G.; Links, T. P.; Panzeri, M.; Rose, M. R.

    2008-01-01

    Background Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. Objectives The objective of this review was to systematical

  9. A Modern Periodic Table.

    Science.gov (United States)

    Herrenden-Harker, B. D.

    1997-01-01

    Presents a modern Periodic Table based on the electron distribution in the outermost shell and the order of filling of the sublevels within the shells. Enables a student to read off directly the electronic configuration of the element and the order in which filling occurs. (JRH)

  10. Periodic Table of Students.

    Science.gov (United States)

    Johnson, Mike

    1998-01-01

    Presents an exercise in which an eighth-grade science teacher decorated the classroom with a periodic table of students. Student photographs were arranged according to similarities into vertical columns. Students were each assigned an atomic number according to their placement in the table. The table is then used to teach students about…

  11. Scheduling: Seven Period Day

    Science.gov (United States)

    Williamson, Ronald

    2010-01-01

    Driven by stable or declining financial resources many school districts are considering the costs and benefits of a seven-period day. While there is limited evidence that any particular scheduling model has a greater impact on student learning than any other, it is clear that the school schedule is a tool that can significantly impact teacher…

  12. Treatment for periodic paralysis

    NARCIS (Netherlands)

    Sansone, [No Value; Meola, G.; Links, T. P.; Panzeri, M.; Rose, M. R.

    2008-01-01

    Background Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. Objectives The objective of this review was to systematical

  13. Chaotic period doubling

    NARCIS (Netherlands)

    Chandramouli, V. V. M. S.; Martens, M.; De Melo, W.; Tresser, C. P.

    2009-01-01

    The period doubling renormalization operator was introduced by Feigenbaum and by Coullet and Tresser in the 1970s to study the asymptotic small-scale geometry of the attractor of one-dimensional systems that are at the transition from simple to chaotic dynamics. This geometry turns out not to depend

  14. 肝移植术后早期严重肝内胆汁淤积的相关因素分析%Risk factors of severe intrahepatic cholestasis during early period after liver transplantation

    Institute of Scientific and Technical Information of China (English)

    张胜; 周杰; 谭永法; 谭凯; 陈立言

    2012-01-01

    (32/165),两组比较,差异有统计学意义(x2=11.54,P<0.05).结论 纠正受者术前不良的临床因素;术后积极控制感染和抗排斥反应可降低原位肝移植患者术后早期严重肝内胆汁淤积的发生率,并有可能改善早期预后.%Objective To investigate the risk factors of severe intrahepatic cholestasis during early period after liver transplantation.Methods The clinical data of 225 patients who received orthotopic liver transplantation at the Nanfang Hospital of Southern Medical University from August 2004 to February 2011 were retrospectively analyzed.All patients were divided into positive group (60 patients with intrahepatic cholestasis) and negative group (165 patients without intrahepatic cholestasis).Preoperative,intraoperative and postoperative factors of the 2 groups were compared via t test,chi-square test,Wilcoxon test or Logistic regression analysis.Results The proportion of patients with hepatic cirrhosis,hepatic encephalopathy integral,ascites integral,international normalized ratio,and the levels of prothrombin time (PT),total bilirubin (TBil),aspartate aminotransferase of the positive group before operation were significantly higher than those in the negative group (x2 =6.09,Z =2.22,2.60,2.46,2.84,4.81,3.42,P < 0.05),while the levels of albumin,Na +,K +,hemoglobin,platelet (PLT) of the positive group in the operation were significantly higher than those in the negative group (t =2.10,4.97,Z =2.49,t =3.51,Z =3.66,P < 0.05).The ratio of compatible blood type of the donors and recipients,ratio of fatty liver graft,cold ischemia time,relative warm ischemia time,intraoperative blood loss,intraoperative transfusion of red blood cells,PLT,and cryoprecipitate of the positive group after the operation were significantly higher than those in the negative group (x2 =4.29,13.11,Z =2.45,2.61,3.75,3.20,2.89,3.95,P <0.05).The incidences of acute rejection,hepatic artery embolism,pulmonary infection

  15. [VIABILITY OF MYOCAROIUM AS RISK FACTOR FOR MORTALITY IN EARLY AND LATE PERIOD AFTER BYPASS SURGERY OF CORONARY ARTERIES IN PATIENTS WITH CORONARY HEART DISEASE AND SEVERE LEFT VENTRICULAR DYSFUNCTION].

    Science.gov (United States)

    Todurov, B M; Zelenchuk, V; Kuzmich, I M; Ivanyuk, N B; Nikolaichuk, M V

    2015-06-01

    In coronary heart disease and low ejection fraction of the left ventricle (LV) in patients after coronary artery bypass surgery tend mortality and complication rate higher than preserved LV systolic function. Significant preoperative predictors of early mortality and remote in these patients, and the incidence of complications in the early postoperative period were reveald.

  16. Thyrotoxic periodic paralysis

    Energy Technology Data Exchange (ETDEWEB)

    Ferreiro, J.E.; Arguelles, D.J.; Rams, H. Jr.

    1986-01-01

    A case of thyrotoxic periodic paralysis is reported in a Hispanic man with an unusual recurrence six weeks after radioactive iodine treatment. Thyrotoxic periodic paralysis has now been well characterized in the literature: it occurs primarily in Orientals with an overwhelming male preponderance and a higher association of specific HLA antigens. Clinical manifestations include onset after high carbohydrate ingestion or heavy exertion, with progressive symmetric weakness leading to flaccid paralysis of the extremities and other muscle groups, lasting several hours. If hypokalemia is present, potassium administration may help abort the attack. Although propranolol can be efficacious in preventing further episodes, the only definitive treatment is establishing a euthyroid state. The pathophysiology is still controversial, but reflects altered potassium and calcium dynamics as well as certain morphologic characteristics within the muscle unit itself.

  17. Cells anticipate periodic events

    Science.gov (United States)

    Nakagaki, Toshiyuki

    2009-03-01

    We show that an amoeboid organism can anticipate the timing of periodic events. The plasmodium of the true slime mold Physarum polycephalum moves rapidly under favourable conditions, but stops moving when transferred to less-favourable conditions. Plasmodia exposed to unfavourable conditions, presented in three consecutive pulses at constant intervals, reduced their locomotive speed in response to each episode. When subsequently subjected to favourable conditions, the plasmodia spontaneously reduced their locomotive speed at the time point when the next unfavourable episode would have occurred. This implied anticipation of impending environmental change. After this behaviour had been evoked several times, the locomotion of the plasmodia returned to normal; however, the anticipatory response could subsequently be induced by a single unfavourable pulse, implying recall of the memorized periodicity. We explored the mechanisms underlying these behaviours from a dynamical systems perspective. Our results hint at the cellular origins of primitive intelligence and imply that simple dynamics might be sufficient to explain its emergence.

  18. Periodic paralysis: understanding channelopathies.

    Science.gov (United States)

    Lehmann-Horn, Frank; Jurkat-Rott, Karin; Rüdel, Reinhardt

    2002-01-01

    Familial periodic paralyses are typical channelopathies (i.e., caused by functional disturbances of ion channel proteins). The episodes of flaccid muscle weakness observed in these disorders are due to underexcitability of sarcolemma leading to a silent electromyogram and the lack of action potentials even upon electrical stimulation. Interictally, ion channel malfunction is well compensated, so that special exogenous or endogenous triggers are required to produce symptoms in the patients. An especially obvious trigger is the level of serum potassium (K+), the ion responsible for resting membrane potential and degree of excitability. The clinical symptoms can be caused by mutations in genes coding for ion channels that mediate different functions for maintaining the resting potential or propagating the action potential, the basis of excitability. The phenotype is determined by the type of functional defect brought about by the mutations, rather than the channel effected, because the contrary phenotypes hyperkalemic periodic paralysis (HyperPP) and hypokalemic periodic paralysis (HypoPP) may be caused by point mutations in the same gene. Still, the common mechanism for inexcitability in all known episodic-weakness phenotypes is a long-lasting depolarization that inactivates sodium ion (Na+) channels, initiating the action potential.

  19. Risk factors for intracerebral hemorrhage and coronary heart diseases over a 3-year period in patients admitted to some hospitals of Tongliao city of Nei Monggol Autonomous Region Retrospective analysis on case data

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    BACKGROUND: Intracerebral hemorrhage(ICH) and coronary heart disease (CHD) have the same pathological base, atherosclerosis, and the similar risk factors, such as smoking ,drinking, hypertension,hyperlipemia, diabetes mellitus, etc; but the distributions of two diseases are very different in the populations.This may be related to the exposure of risk factors and different effects of risk factors on two diseases.OBJECTIVE: To analyze the distribution difference of risk factors for ICH and CHD in the populations of Tongliao city of Nei Monggol Autonomous Region.DESIGN: Retrospective analysis.SETTING: School of Radiation Medicine and Public Health, Soochow University; Tongliao Hospital, Nei Monggol Autonomous Region.PARTICIPANTS: Random sampling was used toselect 6 hospitals from 10 hospitals affiliated to Tongliao City ofNei Monggot Autonomous Region. Totally 1 672 medical records of patients with ICH and 2 195 medical records of patients with CHD admitted to Department of Neurology and Department of Cardiovascular Internal Medicine of above-mentioned 6 hospitals between January 2003 and December 2005 were collected according to the investigation need.METHODS: The subjects, whose medical records were involved, were performed retrospective analysis with pre-prepared questionnaire "Stroke and Coronary Heart Disease Epidemiologic Questionnaire". The main contents included: ①Social demography condition: The distributions of gender, age, nationality, etc. ②Previous history of disease: hypertension, diabetes mellitus, etc. ③Related risk factors: systolic blood pressure, diastolic blood pressure, total cholesterol, triglyceride, high-density lipoprotein cholesterol,low-density lipoprotein cholesterol, smoking, drinking and glucose (GLU). The database of Epidata was transformed to SPSS database. Single-and multiple-factor non-conditional Logistic regression analysis were performed on the data, and OR value and 95% CI were calculated. The distribution differences of

  20. Optimal Concession Period in the Built-Operate-Transfer Project Under Multiple Uncertain Factors%多种不确定因素下BOT模式中最优特许期限研究

    Institute of Scientific and Technical Information of China (English)

    范瑞郑; 万厉; 汪小京

    2012-01-01

    Built-operate-transfer (BOT) is becoming an increasingly popular option of project delivery, and the concession period is a key decision faced by both the government and private investor. Therefore, this paper aims to optimize the concession period in the BOT project by using net present value (NPV). Due to the difficulties in estimating the long-term uncertainties, this paper develops a Monte Carlo simulation model to reveal the relationship between the uncertainties and concession period. At the end, a numerical example is given to provide the optimal concession period.%BOT模式已经成为公私合作的基础设施融资的主要方式之一,其中特许期限是BOT项目成功的关键因素,关系到政府部门公共资源,以及项目投资者的投资利润.考虑到BOT项目时间跨度大,存在多种不确定因素,设计了蒙特卡罗模拟模型,用特定的概率分布函数拟合建设工期、建设成本、收费价格、市场需求、运营和维护成本等关键风险因素,进而模拟出项目公司的NPV曲线,在期望的内含报酬率下及给定的置信水平下求解最优特许期限,从而揭示了不确定性因素和特许期限之间的关系.最后,给出一个高速公路BOT项目的算例,证实了算法的有效性.

  1. Long Period Seismic Waves

    Science.gov (United States)

    1976-08-01

    maximum intensity (MM) at a given distance D = population density 0<Bə G = reology factor 0<Gə K = Rmax - R Rmax Rmax = —p- Log (Io...and reology fac tor may be assigned to each plotted intensity point. 5. With all those parameters the ISR may be constructed. The results of such

  2. Periodic Mesoporous Organosilica Nanorice

    Directory of Open Access Journals (Sweden)

    Mohanty Paritosh

    2008-01-01

    Full Text Available Abstract A periodic mesoporous organosilica (PMO with nanorice morphology was successfully synthesized by a template assisted sol–gel method using a chain-type precursor. The PMO is composed of D and T sites in the ratio 1:2. The obtained mesoporous nanorice has a surface area of 753 m2 g−1, one-dimensional channels, and a narrow pore size distribution centered at 4.3 nm. The nanorice particles have a length of ca. 600 nm and width of ca. 200 nm.

  3. Periods of Hecke characters

    CERN Document Server

    Schappacher, Norbert

    1988-01-01

    The starting point of this Lecture Notes volume is Deligne's theorem about absolute Hodge cycles on abelian varieties. Its applications to the theory of motives with complex multiplication are systematically reviewed. In particular, algebraic relations between values of the gamma function, the so-called formula of Chowla and Selberg and its generalization and Shimura's monomial relations among periods of CM abelian varieties are all presented in a unified way, namely as the analytic reflections of arithmetic identities beetween Hecke characters, with gamma values corresponding to Jacobi sums. The last chapter contains a special case in which Deligne's theorem does not apply.

  4. Factores de riesgo para complicaciones en el periodo de recuperación post anestésica en el paciente anciano Fatores de risco para complicações no período de recuperação pós anestésica no paciente idoso Risk factors for complications in the post anesthesia period in elderly patients

    Directory of Open Access Journals (Sweden)

    Isabel Yovana Quispe Mendoza

    2010-11-01

    Full Text Available Objetivos. Identificar los factores de riesgo para complicaciones en el periodo de recuperación post anestésica en el paciente anciano. Metodología. Estudio descriptivo retrospectivo. Los datos fueron recolectados de las historias clínicas de pacientes ancianos. Resultados. Se estudiaron 110 pacientes que tuvieron este perfil: sexo masculino (56.4%, hipertensos (32.7% y fueron clasificados en ASA II (60.0%. En cuanto al intraoperatorio: fueron sometidos a cirugía abdominal (53.6%, les administraron anestesia general (50.9%, estuvieron durante la cirugía posición de decúbito dorsal (81.8% y el período intraoperatorio fue inferior a tres horas (62.7%. Las complicaciones más frecuentes fueron: hipotermia (55.5%, dolor (43.6% y aumento de la presión arterial (36.4%. Conclusión. Se evidenció la importancia de la visita preoperatoria con la finalidad de evaluar los factores de riesgo que puedan influenciar en el procedimiento quirúrgico.Objetivos. Identificar os fatores de risco para complicações no período de recuperação pós anestésica no paciente idoso. Metodologia. Estudo descritivo retrospectivo. Os dados foram coletados das histórias clínicas de pacientes idosos. Resultados. Estudaram-se 110 pacientes que tiveram este perfil: sexo masculino (56.4%, hipertensos (32.7% e foram classificados em ASA II (60.0%. Quanto ao intra-operatório: foram submetidos a cirurgia abdominal (53.6%, administraram-lhes anestesia geral (50.9%, estiveram durante a cirurgia posição de decúbito dorsal (81.8% e o período intra-operatório foi inferior a três horas (62.7%. As complicações mais freqüentes foram: hipotermia (55.5%, dor (43.6% e aumento da pressão arterial (36.4%. Conclusão. Evidenciou-se a importância da visita pré-operatória com a finalidade de avaliar os fatores de risco que possam influenciar no procedimento cirúrgico.Objective. To identify the risk for complications in the post anesthesia recovery period in elderly

  5. Does the impact of subsequent incontinence risk factors depend on continence status during the first pregnancy or the postpartum period 12 years before? A cohort study in 232 primiparous women

    DEFF Research Database (Denmark)

    Viktrup, L.; Rortveit, G.; Lose, G.

    2008-01-01

    extent pelvic organ prolapse symptoms or heavy lifting at work was associated with higher relative risk of urinary incontinence in group 1 compared with group 2. Other risk factors such as age, breastfeeding 6 months or longer after both the first and second deliveries, bowel movements or urinary...

  6. Periodic truss structures

    Science.gov (United States)

    Zok, Frank W.; Latture, Ryan M.; Begley, Matthew R.

    2016-11-01

    Despite the recognition of the enormous potential of periodic trusses for use in a broad range of technologies, there are no widely-accepted descriptors of their structure. The terminology has been based loosely either on geometry of polyhedra or of point lattices: neither of which, on its own, has an appropriate structure to fully define periodic trusses. The present article lays out a system for classification of truss structure types. The system employs concepts from crystallography and geometry to describe nodal locations and connectivity of struts. Through a series of illustrative examples of progressively increasing complexity, a rational taxonomy of truss structure is developed. Its conceptual evolution begins with elementary cubic trusses, increasing in complexity with non-cubic and compound trusses as well as supertrusses, and, finally, with complex trusses. The conventions and terminology adopted to define truss structure yield concise yet unambiguous descriptions of structure types and of specific (finite) trusses. The utility of the taxonomy is demonstrated by bringing into alignment a disparate set of ad hoc and incomplete truss designations previously employed in a broad range of science and engineering fields. Additionally, the merits of a particular compound truss (comprising two interpenetrating elementary trusses) is shown to be superior to the octet truss for applications requiring high stiffness and elastic isotropy. By systematically stepping through and analyzing the finite number of structure types identified through the present classification system, optimal structures for prescribed mechanical and functional requirements are expected to be ascertained in an expeditious manner.

  7. The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28.

    Science.gov (United States)

    Tschische, Pia; Moser, Elisabeth; Thompson, Dawn; Vischer, Henry F; Parzmair, Gerald P; Pommer, Veronika; Platzer, Wolfgang; Schwarzbraun, Thomas; Schaider, Helmut; Smit, Martine J; Martini, Lene; Whistler, Jennifer L; Waldhoer, Maria

    2010-05-01

    Human cytomegalovirus (HCMV) encodes the seven transmembrane(7TM)/G-protein coupled receptor (GPCR) US28, which signals and endocytoses in a constitutive, ligand-independent manner. Here we show that, following endocytosis, US28 is targeted to the lysosomes for degradation as a consequence of its interaction with the GPCR-associated sorting protein-1 (GASP-1). We find that GASP-1 binds to US28 in vitro and that disruption of the GASP-1/US28 interaction by either (i) overexpression of dominant negative cGASP-1 or by (ii) shRNA knock-down of endogenous GASP-1 is sufficient to inhibit the lysosomal targeting of US28 and slow its post-endocytic degradation. Furthermore, we found that GASP-1 affects US28-mediated signalling. The knock-down of endogenous GASP-1 impairs the US28-mediated Galphaq/PLC/inositol phosphate (IP) accumulation as well as the activation of the transcription factors Nuclear Factor-kappaB (NF-kappaB) and cyclic AMP responsive element binding protein (CREB). Overexpression of GASP-1 enhances both IP accumulation and transcription factor activity. Thus, GASP-1 is an important cellular determinant that not only regulates the post-endocytic trafficking of US28, but also regulates the signalling capacities of US28.

  8. New Realization of Periodic Cycled Separation

    DEFF Research Database (Denmark)

    Toftegard, Bjarne; Clausen, Charlotte H.; Jørgensen, Sten B.;

    2016-01-01

    A new realization of periodic cycled gas/liquid separation is presented. Separation factors and column efficiencies are compared for a column stripping ammonia from water with air, using three different sets of internals: conventional sieve trays, Sulzer BX gauze packings, and periodically cycled...... trays. The proposed new periodic trays are shown to be advantageous compared to their continuous alternatives. It is demonstrated experimentally that periodic tray efficiencies of up to 300% are achievable. With the proposed new tray design, a new operation form is also introduced in which the trays...... are drained sequentially rather than simultaneously, such that the vapor flow is not interrupted during the liquid drainage. For different ratios of counter-current vapor/liquid flow rates, column efficiencies for periodically cycled columns are shown experimentally to be two times greater than those...

  9. Quantitative structure-activity relationship (QSAR) study of interleukin-1 receptor associated kinase 4 (IRAK-4) inhibitor activity by the genetic algorithm and multiple linear regression (GA-MLR) method.

    Science.gov (United States)

    Pourbasheer, Eslam; Riahi, Siavash; Ganjali, Mohammad Reza; Norouzi, Parviz

    2010-12-01

    A linear quantitative structure-activity relationship (QSAR) model is presented for the modelling and prediction for the interleukin-1 receptor associated kinase 4 (IRAK-4) inhibition activity of amides and imidazo[1,2-α] pyridines. The model was produced using the multiple linear regression (MLR) technique on a database that consisted of 65 recently discovered amides and imidazo[1,2- α] pyridines. Among the different constitutional, topological, geometrical, electrostatic and quantum-chemical descriptors that were considered as inputs to the model, seven variables were selected using the genetic algorithm subset selection method (GA). The accuracy of the proposed MLR model was illustrated using the following evaluation techniques: cross-validation, validation through an external test set, and Y-randomisation. The predictive ability of the model was found to be satisfactory and could be used for designing a similar group of compounds.

  10. When Periodicities Enforce Aperiodicity

    Science.gov (United States)

    Bédaride, Nicolas; Fernique, Thomas

    2015-05-01

    Non-periodic tilings and local rules are commonly used to model the long range aperiodic order of quasicrystals and the finite-range energetic interactions that stabilize them. This paper focuses on planar rhombus tilings, which are tilings of the Euclidean plane, which can be seen as an approximation of a real plane embedded in a higher dimensional space. Our main result is a characterization of the existence of local rules for such tilings when the embedding space is four-dimensional. The proof is an interplay of algebra and geometry that makes use of the rational dependencies between the coordinates of the embedded plane. We also apply this result to some cases in a higher dimensional embedding space, notably tilings with n-fold rotational symmetry.

  11. Periods and Superstring Amplitudes

    CERN Document Server

    Stieberger, S

    2016-01-01

    Scattering amplitudes which describe the interaction of physical states play an important role in determining physical observables. In string theory the physical states are given by vibrations of open and closed strings and their interactions are described (at the leading order in perturbation theory) by a world-sheet given by the topology of a disk or sphere, respectively. Formally, for scattering of N strings this leads to N-3-dimensional iterated real integrals along the compactified real axis or N-3-dimensional complex sphere integrals, respectively. As a consequence the physical observables are described by periods on M_{0,N} - the moduli space of Riemann spheres of N ordered marked points. The mathematical structure of these string amplitudes share many recent advances in arithmetic algebraic geometry and number theory like multiple zeta values, single-valued multiple zeta values, Drinfeld, Deligne associators, Hopf algebra and Lie algebra structures related to Grothendiecks Galois theory. We review the...

  12. 早产儿晚期"屏气发作"相关危险因素分析%Study on Risk Factors of Breath Holding Spell in Later Period of Premature Neonatals with Hypocaicemia

    Institute of Scientific and Technical Information of China (English)

    陆丹; 彭巧英; 管婉华; 胡洪波

    2011-01-01

    目的 探讨早产儿晚期"屏气发作"的原因及干预措施.方法 按照对本院新生儿科2006年6月-2009年6月出院后2~4周的早产儿进行了随访,并记录出生时一般情况、随访时日龄、日期(季节)、喂养方式和出院后的疾病征象等;采用雷度ABL800血气分析仪测定微量血Ca2+、K+、Na+.结果 早产儿晚期"屏气发作"的原因与"低离子钙血症"相关,补充钙剂和维生素AD可缓解症状.结论 "屏气发作"有可能是"低钙惊厥"的特殊表现形式,是早产儿晚期常见的疾病征象;目睹其发作过程,可能存有"低氧血症"而加重已有脑损伤的早产儿病情;屏气发作导致睡眠障碍不仅继续影响、干扰其生长发育,且引起儿童时期各系统疾病,导致早产儿不良结局.%Objective To study the undesirable consequences and intervention measures of breath holding spell in later period of the premature neonatals. Methods All the premature neonatals hospitalized in Hubei Maternal and Child Health Hospital from June, 2006 to June, 2009 were followed up 2~4 weeks after hospital discharge. The general state of health, age, date (season), feeding- pattems and clinical symptoms of the premature neonatals were recorded. Clinical analysis of electrolytes change of breath holding spell was also performed. Results The causation of breathholding spell in later period of the premature neonatals was interrelated with hypocalcemia. It was effective to supplement calcium and vitamin AD to relief the symptoms. Conclusions As a particular manifestation of hypocalcemia, breath holding spell is a common symptom in later period of the premature neonatals. So far as what we witness, it is likely that hypoxemia aggravates the illness of the premature neonatal that has a brain injury. As a result of breath holding spell, sleeping disturbance not only affects and interferes with the growth and development of the patients, but also leads to the systematic diseases during

  13. Cyclic Period in the CBE Model

    CERN Document Server

    Frampton, Paul H

    2016-01-01

    In a cyclic entropy model in which the extroverse is jettisoned at turnaround with a Come Back Empty (CBE) assumption, we address matching of the contaction scale factor $\\hat{a}(t)=f(t_T){a}(t)$ to the expansion scale factor $a(t)$, where $f(t_T)$ is the ratio at turnaround of the introverse to extroverse radii. Such matching is necessary for infinite cyclicity and fixes the CBE period at $\\sim 2.6Ty$.

  14. [Childhood periodic syndromes].

    Science.gov (United States)

    Cuvellier, J-C; Lépine, A

    2010-01-01

    This review focuses on the so-called "periodic syndromes of childhood that are precursors to migraine", as included in the Second Edition of the International Classification of Headache Disorders. Three periodic syndromes of childhood are included in the Second Edition of the International Classification of Headache Disorders: abdominal migraine, cyclic vomiting syndrome and benign paroxysmal vertigo, and a fourth, benign paroxysmal torticollis is presented in the Appendix. The key clinical features of this group of disorders are the episodic pattern and intervals of complete health. Episodes of benign paroxysmal torticollis begin between 2 and 8 months of age. Attacks are characterized by an abnormal inclination and/or rotation of the head to one side, due to cervical dystonia. They usually resolve by 5 years. Benign paroxysmal vertigo presents as sudden attacks of vertigo, accompanied by inability to stand without support, and lasting seconds to minutes. Age at onset is between 2 and 4 years, and the symptoms disappear by the age of 5. Cyclic vomiting syndrome is characterized in young infants and children by repeated stereotyped episodes of pernicious vomiting, at times to the point of dehydration, and impacting quality of life. Mean age of onset is 5 years. Abdominal migraine remains a controversial issue and presents in childhood with repeated stereotyped episodes of unexplained abdominal pain, nausea and vomiting occurring in the absence of headache. Mean age of onset is 7 years. Both cyclic vomiting syndrome and abdominal migraine are noted for the absence of pathognomonic clinical features but also for the large number of other conditions to be considered in their differential diagnoses. Diagnostic criteria, such as those of the Second Edition of the International Classification of Headache Disorders and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, have made diagnostic approach and management easier. Their diagnosis

  15. [Relationship between climate change and determinant factors of mortality among the elderly in the municipality of São Carlos (São Paulo, Brazil) over a period of ten years].

    Science.gov (United States)

    Soares, Fabiana Vieira; Greve, Patrícia; Sendín, Francisco Alburquerque; Benze, Benedito Galvão; de Castro, Alessandra Paiva; Rebelatto, José Rubens

    2012-01-01

    The aim of this study was to identify the correlation between the number of deaths of elderly people and climate change in the district of São Carlos (SP) over a period of 10 years (1997-2006). Records of deaths were obtained from DATASUS for people aged over 60 who died between 1997 and 2006 in São Carlos. The average monthly maximum and minimum temperature data and relative air humidity in São Carlos were provided by the National Institute of Meteorology. The mortality coefficient of the district was calculated by gender and age and the resulting data were analyzed using t test, one-way ANOVA, the Bonferroni test and the Pearson correlation coefficient test. There were 8,304 deaths which predominantly occurred among males aged over 80, and diseases of the circulatory system were the main cause of death. There was a positive correlation between mortality by infectious disease and minimum humidity, and a negative correlation between mortality by infectious diseases and minimum temperatures, between mortality caused by respiratory disease and minimum humidity, between mortality caused by endocrine disease and minimum and maximum temperature. Thereby, it was possible to conclude that there was a correlation between climate change and mortality among elderly individuals in São Carlos.

  16. Near periodicity in dynamical systems

    Institute of Scientific and Technical Information of China (English)

    陈文成

    1995-01-01

    The notion of near periodicity is shown to be equivalent to that of weak near periodicity in dynamical systems. A sufficient condition for the positive near periodicity of a point in dynamical systems is given. The structure of nearly periodic dynamical systems is discussed, and a condition is proved to be necessary and sufficient for a dynamical system on a local compact space to be positively nearly periodic.

  17. Periodicity-dependent stiffness of periodic hydrophilic-hydrophobic heteropolymers

    Science.gov (United States)

    Chowdhury, Debashish; Stauffer, Dietrich; Strey, Reinhard

    1999-08-01

    From extensive Monte Carlo simulations of a Larson model of perfectly periodic heteropolymers (PHP) in water, a striking stiffening is observed as the period of the alternating hydrophobic and hydrophilic blocks is shortened. At short period and low temperature needlelike conformations are the stable conformations. As temperature is increased thermal fluctuations induce kinks and bends. At large periods compact oligomeric globules are observed. From the generalized Larson prescription, originally developed for modeling surfactant molecules in aqueous solutions, we find that the shorter the period is the more stretched the PHP is. This novel effect is expected to stimulate polymer synthesis and trigger research on the rheology of aqueous periodic heteropolymer solutions.

  18. THE WAVELET TRANSFORM OF PERIODIC FUNCTION AND NONSTATIONARY PERIODIC FUNCTION

    Institute of Scientific and Technical Information of China (English)

    刘海峰; 周炜星; 王辅臣; 龚欣; 于遵宏

    2002-01-01

    Some properties of the wavelet transform of trigonometric function, periodic function and nonstationary periodic function have been investigated. The results show that the peak height and width in wavelet energy spectrum of a periodic function are in proportion to its period. At the same time, a new equation, which can truly reconstruct a trigonometric function with only one scale wavelet coefficient, is presented. The reconstructed wave shape of a periodic function with the equation is better than any term of its Fourier series. And the reconstructed wave shape of a class of nonstationary periodic function with this equation agrees well with the function.

  19. Fatores antinutricionais da casca e da polpa desidratada de café (Coffea arabica L. armazenadas em diferentes períodos Antinutritional factors of the hull and dehydrated pulp of coffee (Coffea arabica L. stored in different periods

    Directory of Open Access Journals (Sweden)

    Adauto Ferreira Barcelos

    2001-07-01

    of tannin were of 2.77% compared with 1.70% in the materials without storage. The reduction was of 38.6% in one year period. Lignin contents were reduced linearly in 2.6% for lignin percentage in DM (11.7 to 11.4% and 5.8% in the lignin percentage of NDF (10.4 to 9.8% in the materials with no storage compared to 12-month storage. There was a significant difference between the hull and pulp for the variable silica. Increased value of silica in the hull, compared to the pulp may be due to the presence of parchment in this material, since this pulp does no possess it. The storage of hull and pulp for a 12-month period improves the qualities of these materials since it reduced tannin and lignin contents. The values of caffeine found are limiting in the use of great amounts of those materials for ruminants.

  20. 内外取热器影响装置长周期运行的因素及对策%Effects of Internal and External Heat Exchanger Device for Long Period Operation Factors and Countermeasures

    Institute of Scientific and Technical Information of China (English)

    艾克利; 张玉宝; 康钰海; 李宏; 郭保宏; 安德会

    2012-01-01

    External heat exchanger main failure form of tube bundle leakage and finned tube distortion,the main reason is the erosion wear,corrosion,welding defects and their structure is not reasonable.The paper on the 60 Mt / a device of heavy oil catalytic cracking heat exchanger in the production of the problems in the running process,influence factors,management and technical defects of the effects obtained after analysis,in order to prolong the using life of external heat exchanger,energy saving,promoting device for diesel and jet operation purpose.%内外取热器失效的主要表现形式为管束泄漏和翅片管变形,其主要原因是冲蚀磨损、腐蚀穿孔、焊接缺陷以及结构不合理等。文章就60 Mt/a重油催化裂化装置取热器在生产运行过程中出现的问题、影响因素、管理缺陷以及技改后所取得的成效加以分析,以期延长外取热器使用寿命,节能降耗,促进装置安稳长满优运行的目的。

  1. 新时期护士慎独修养的表现及影响因素分析%Performance of Nurse′s Cautiousness and its Influential Factors in the New Period

    Institute of Scientific and Technical Information of China (English)

    张一红

    2016-01-01

    在论述了慎独修养在现代护理工作中的表现及影响因素的基础上,提出培养与提升慎独修养的对策,具体有:加强对护士的教育培训,提高护士的职业道德水准;合理配置护理人力资源,完善医院激励措施;实施赏识激励,营造良好的工作环境;自觉践行护士伦理准则,弘扬护理专业精神。%Based on the review of cautiousness in the modern nursing work and its influential factors, this pa-per put forward the countermeasures to improve cautiousness: enhancing the educational training and improving nursing professional moral level, allocating human resource reasonably and perfecting incentive system;implemen-ting appreciation incentive and creating a good working environment;practicing nurse ethics consciously and promo-ting the nursing professional spirit.

  2. Persistence in periodic and almost periodic Lotka-Volterra systems.

    Science.gov (United States)

    Gopalsamy, K

    1984-01-01

    It is shown that a strongly self-regulating (or resource limited) Lotka-Volterra population system can "persist" in a periodic or almost periodic environment if and only if the system tracks the environmental variations.

  3. Photolysis of Periodate and Periodic Acid in Aqueous Solution

    DEFF Research Database (Denmark)

    Sehested, Knud; Kläning, U. K.

    1978-01-01

    The photochemistry of periodate and periodic acid in aqueous solution was studied (i) by quantum yield measurements at low light intensity (ii) by flash photolysis, and (iii) by photolysis of glassy samples at 77 K. The photochemical studies were supplemented with pulse radiolysis studies...... of aqueous periodate solutions and with kinetic studies using stopped-flow technique. In strongly alkaline solution the photodecomposition of periodate proceeds via formation of O– and IVI. At pH

  4. 象山半岛地区妊娠期糖代谢异常影响因素的分析%Analysis on the affecting factors of glycometabolic abnormalities of gestational period in the region of Xiangshan peninsula

    Institute of Scientific and Technical Information of China (English)

    吴美飞; 徐旦

    2013-01-01

    Objective To understand the incidence and its influencing factors of glycometabolic abnormalities during pregnancy in the region of Xiangshan peninsula Methods The 965 pregnant women having routine antenatal examinations who were volunteers to receive the survey were enrolled in this trial.They were given the measurement of FPG in the 13th week and the 50 gGCT in the 24th ~28th week of pregnancy.Those who had a positive GCT result would be given an 75 gOGTT for diagnosis of GDM and IGT.Results Of the 965 Cases,the detectable rate of GCT was 22.80%,the incidence of GDM was 2.69%,the detectable rate of IGT was 3.52%.The incidence of glucose metabolism abnormalities was positively associated with the age of gravida,pregnancy times,and BMI,and negatively with the pregnant women's own birth weight.Conclusion Increased age,obesity,low birth weight,and multiple pregnancy are the high risk factors of the incidence of glucose metabolism abnormalities.It is necessary to strengthen the preconception counseling,advocate planning pregnancy,and control body weight during pregnancy.%目的 了解象山半岛地区妊娠期糖代谢异常的发病率,探讨妊娠期妇女年龄、BMI及胎产次对50 g葡萄糖负荷试验(50 gGCT)、IGT、妊娠期糖尿病(GDM)发病率的影响. 方法 选择常规产检并自愿接受调查的妊娠期妇女965名,分别在妊娠13周内监测FPG,于24~28周行GCT.GCT(+)者进一步行75 gOGTT,根据结果诊断为GDM及IGT. 结果 965名妊娠期妇女GCT(+)检出率22.800,GDM的发病率为2.69%,IGT的检出率为3.52%.妊娠期糖代谢异常的发病率与妊娠期妇女年龄的增加、妊娠次数的增多、BMI上升呈正相关,而与妊娠期妇女本人的出生体重呈负相关.结论 高龄、肥胖、出生低体重、多次妊娠是妊娠期糖代谢异常的高危因素,加强妊娠前咨询,提倡计划妊娠,控制妊娠期体重十分必要.

  5. Risk factors and predictors of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii mortality in critically ill bacteraemic patients over a 6-year period (2010-15): antibiotics do matter.

    Science.gov (United States)

    Papadimitriou-Olivgeris, Matthaios; Fligou, Fotini; Spiliopoulou, Anastasia; Koutsileou, Kyriaki; Kolonitsiou, Fevronia; Spyropoulou, Aikaterini; Zotou, Anastasia; Marangos, Markos; Anastassiou, Evangelos D; Christofidou, Myrto; Spiliopoulou, Iris

    2017-07-31

    Acinetobacter baumannii and Pseudomonas aeruginosa provoke serious infections, especially in intensive care unit (ICU) patients. The risk factors and predictors of mortality for P. aeruginosa (n=84; 46 carbapenem-resistant) and A. baumannii (n=129; all carbapenem-resistant) bloodstream infections (BSIs) in an ICU were evaluated. Antibiotic susceptibility testing was performed using the agar disk diffusion method according to EUCAST guidelines. The minimum inhibitory concentration was determined by a gradient method (Etest). Multilocus sequence typing (MLST) was performed for P. aeruginosa during the carbapenem-resistant outbreak in 2014. Epidemiological data were collected from the patients' chart reviews.Results/Key findings. Hospitalization during the summer months, prior KPC-producing Klebsiella pneumoniae (KPC-Kp) BSI, and the administration of tigecycline, aminoglycosides and cortisone were independently associated with P. aeruginosa BSIs. MLST revealed the dissemination of clone ST227, including carbapenem-resistant P. aeruginosa strains. Hospitalization during the summer months, prior KPC-Kp BSI, and the administration of antibiotics, carbapenem and cortisone were independently associated with A. baumannii BSIs. The 30-day mortality rate for P. aeruginosa and A. baumannii BSI was 45.2 and 39.5 %, respectively. Sequential organ failure assessment (SOFA) score at onset, septic shock, age, and prior KPC-Kp BSI were significantly associated with P. aeruginosa BSI mortality. The administration of at least one active antibiotic was identified as a predictor of a good prognosis. Septic shock and simplified acute physiology score (SAPS) II at onset were independently associated with A. baumannii BSI mortality. The administration of at least one active antibiotic and colistin-vancomycin co-administration were identified as predictors of a good prognosis. KPC-Kp infection predisposes ICU patients to BSI by either A. baumannii or P. aeruginosa. The administration of

  6. Spatial variability of soil moisture content and its influencing factors in small Karst catchment during dry period%喀斯特小流域土壤含水率空间异质性及其影响因素

    Institute of Scientific and Technical Information of China (English)

    付同刚; 陈洪松; 张伟; 高鹏; 王克林

    2014-01-01

    and other soil properties, including bulk density (BD), capillary capacity (CP), non-capillary capacity (NCP), soil organic carbon (SOC), and rock fragment content (RC). Environmental factors including topographical position (upper-slope, middle-slope, lower-slope and depression), land use type (forestland, shrubland, shrub-grassland and farmland), slope gradient (SG), slope aspect (SA) and bare rock (BR) were investigated around the sampling points. Spatial variability of SMC and its influencing factors were analyzed by both geostatistical and classical analysis methods. The results showed that the mean value of SMC was 34.43%. The SMC had a moderate variation with the coefficient of variation of 0.33. The geostatistical results showed that the semivariance of SMC was best fitted by exponential model with a higher determination coefficient of 0.910. The range was 381.00 m and the nugget/sill value was 0.382, indicating a moderate spatial correlation of SMC. When the lag distance was smaller than 200 m, the variation in 120° direction was higher than that of 30° direction. However, when the lag distance was exceeded 200 m, no anisotropy was found in 120° and 30° directions with the anisotropy ratio fluctuated around 1. The Kriging map showed that SMC generally decreased with the increasing altitude. Most of the slope had a lower SMC value less than 35%. The highest SMC value always appeared in the east of the depression which was higher than 50%. The Pearson correlation analysis showed that CP had a significant (p<0.01) positive correlation with SMC but RC and BD had a significant negative correlation with SMC. NCP had a significantly negatives effect on SMC with the significant value of 0.022. However, SOC only significantly affected SMC at 0.10 level. This suggested that all the soil properties had important influence on SMC. However, for the topographical factors, only SG had a significant influence on SMC with the correlation coefficient of-0.435 (p<0

  7. Ecology from the Perspective of Analysis on the Factors Restricting Development of China′s Cartoon Periodicals%生态学视角下我国动漫类期刊发展制约因素探析

    Institute of Scientific and Technical Information of China (English)

    张志钊

    2014-01-01

    Anime journals as the front end of the animation industry chain,is the pioneer of the animation indus-try development.In recent years,the journal of the Chinese animation market presents the explosive growth of the deteriorating ecological environment at the same time.Elements in the system main body and anime have open,dynamic and network system,supporting policies lack of pertinence and operability,and publication man-agement system reform lags behind the policy environment;Animation industry chain of each node lack of con-tact,communication and cooperation,market orientation and layout is messy,homogeneity and low level compe-tition,the industry environment;Original animation works and journal editors and lack of business resources and environment is a major factor which restricts the healthy development of anime journals.%动漫期刊作为动漫产业链的前端,是动漫产业发展的先行者。近年来,中国动漫期刊市场呈现井喷式发展的同时其生态环境逐渐恶化。在动漫期刊这个系统主体和要素都具有开放性、动态性和网络化的系统中,扶持政策缺少针对性和可操作性以及出版市场秩序管理制度改革滞后的政策环境;动漫产业链各节点缺乏联系、沟通、合作,市场定位和布局凌乱,同质化低水平竞争的产业环境;动漫作品原创和期刊编辑、经营人才匮乏的资源环境是制约动漫期刊健康发展的主要因素。

  8. Periodic feedback stabilization for linear periodic evolution equations

    CERN Document Server

    Wang, Gengsheng

    2016-01-01

    This book introduces a number of recent advances regarding periodic feedback stabilization for linear and time periodic evolution equations. First, it presents selected connections between linear quadratic optimal control theory and feedback stabilization theory for linear periodic evolution equations. Secondly, it identifies several criteria for the periodic feedback stabilization from the perspective of geometry, algebra and analyses respectively. Next, it describes several ways to design periodic feedback laws. Lastly, the book introduces readers to key methods for designing the control machines. Given its coverage and scope, it offers a helpful guide for graduate students and researchers in the areas of control theory and applied mathematics.

  9. The redoubtable ecological periodic table

    Science.gov (United States)

    Ecological periodic tables are repositories of reliable information on quantitative, predictably recurring (periodic) habitat–community patterns and their uncertainty, scaling and transferability. Their reliability derives from their grounding in sound ecological principle...

  10. The redoubtable ecological periodic table

    Science.gov (United States)

    Ecological periodic tables are repositories of reliable information on quantitative, predictably recurring (periodic) habitat–community patterns and their uncertainty, scaling and transferability. Their reliability derives from their grounding in sound ecological principle...

  11. Doubly Resonant Optical Periodic Structure.

    Science.gov (United States)

    Alagappan, G; Png, C E

    2016-02-08

    Periodic structures are well known in various branches of physics for their ability to provide a stopband. In this article, using optical periodic structures we showed that, when a second periodicity--very closed to the original periodicity is introduced, large number of states appears in the stopband corresponding to the first periodicity. In the limit where the two periods matches, we have a continuum of states, and the original stopband completely disappears. This intriguing phenomena is uncovered by noticing that, regardless of the proximities of the two periodicities, there is an array of spatial points where the dielectric functions corresponding to the two periodicities interfere destructively. These spatial points mimic photonic atoms by satisfying the standards equations of quantum harmonic oscillators, and exhibit lossless, atom-like dispersions.

  12. Periodic review and continuous ordering

    OpenAIRE

    Prak, Dennis R.J.; Teunter, Ruud; Riezebos, Jan

    2014-01-01

    There exist many inventory control studies that consider either continuous review & continuous ordering, or periodic review & periodic ordering. Mixtures of the two are hardly ever studied. However, the model with periodic review and continuous ordering is highly relevant in practice, as information on the actual inventory level is not always up to date while making ordering decisions. This paper will therefore consider this case of periodic review and continuous ordering. Assuming zero fixed...

  13. Intraventricular hemorrhage in very low birth weight infants: associated risk factors and outcome in the neonatal period Hemorragia intracranianana: evolução dos recém-nascidos de baixo peso no período neonatal

    Directory of Open Access Journals (Sweden)

    Monique Catache Mancini

    1999-10-01

    Full Text Available Intraventricular hemorrhage (IVH is a severe complication in very low birth weight (VLBW newborns (NB. With the purpose of studying the incidence of IVH, the associated risk factors, and the outcomes for these neonates, we studied all the VLBW infants born in our neonatal unit. Birth weight, gestational age, presence of perinatal asphyxia, mechanical ventilation, length of hospitalization, apnea crisis, hydrocephalus, and periventricular leukomalacia were analyzed. The diagnosis of IVH was based on ultrasound scan studies (Papile's classification performed until the tenth day of life and repeated weekly in the presence of abnormalities. Sixty-seven/101 neonates were studied. The mortality rate was 30.6% (31/101 and the incidence of IVH was 29.8% (20/67 : 70% grade I, 20% grade III and 10% grade IV. The incidence of IVH in NB A hemorragia intracraniana constituí uma grave complicação na evolução dos recém-nascidos de muito baixo peso (RN-MBP no período neonatal. Realizou-se este estudo, incluindo os recém-nascidos de muito baixo peso admitidos no Berçário Anexo à Maternidade do Hospital das Clínicas da FMUSP, com o objetivo de determinar a incidência de hemorragia intracraniana (HIC, os fatores de risco associados e sua evolução no período neonatal. Foram analisados o peso de nascimento, idade gestacional, presença de asfixia neonatal, uso de ventilação mecânica, tempo de internação, presença de episódios de apnéia, hidrocefalia e leucoencefalomalácia. O diagnóstico de HIC baseou-se no exame ultra-sonográfico realizado até o décimo dia de vida, de acordo com a classificação de Papille. Foram admitidos no período 101 RN-MBP, dos quais 67 preencheram aos critérios de inclusão. A taxa de mortalidade do período foi de 30,6% (31/101 e a incidência de HIC foi de 29,8% (20/67, sendo 70% grau I, 20 grau II e 10% grau IV. A incidência de HIC em recém-nascidos com peso de nascimento menos do que 1000g foi de 53,8% (p

  14. Analysis on related risk factors for bronchial asthma in children and maternal pregnancy and neonatal periods%儿童支气管哮喘与母孕期及新生儿期相关危险因素分析

    Institute of Scientific and Technical Information of China (English)

    黄晓玲; 刘佳; 张小芳

    2015-01-01

    目的:对儿童支气管哮喘与母孕期及新生儿期相关危险因素进行分析。方法以2012年3月至2014年1月确诊并治疗的127例儿童支气管哮喘患儿为观察组;随机选择同期的152例正常儿童作为对照组。对所有入选对象母孕期及新生儿期的相关资料进行调查。结果单因素分析结果提示观察组和对照组早孕期发热、孕早期服药史、妊娠高血压综合征、1分钟 Apgar 评分<7分、出生体重<2500 g、孕龄<37周、剖宫产率相比差异有统计学意义( P <0.05);对单因素分析有意义的因素进行多因素分析,结果提示早孕期发热、胎龄<37周及剖宫产结束分娩是儿童支气管哮喘发生的独立危险因素。结论早孕期发热、胎龄<37周及剖宫产结束分娩是儿童支气管哮喘发生的独立危险因素。了解这些因素,早期进行干预对降低儿童支气管哮喘的发生率有重要的意义。%Objective To analyze related risk factors of bronchial asthma in children and maternal and neonatal periods. Methods A to-tal of 127 pediatric patients with bronchial asthma during March 2012 to January 2014 were diagnosed and listed in observation group,and 152 nor-mal children in the same period were randomly selected as control group. All relevant information on selected objects during pregnancy and neonatal period had been studied. Results Single factor analysis indicated that the difference in early pregnancy period,fever,history of medication,preg-nancy induced hypertension syndrome,1 minute Apgar scores < 7,birth weight < 2 500 g,gestational age < 37 weeks and the rate of cesarean section compared between these 2 groups was statistically significant( P < 0. 05);the result of multi - factors analysis suggested that fever in early pregnancy period,gestational age < 37 weeks and caesarean birth were independent risk factors for bronchial asthma in children. Conclusion Fe-ver in early pregnancy period

  15. Periodic review and continuous ordering

    NARCIS (Netherlands)

    Prak, Dennis; Teunter, Ruud; Riezebos, Jan

    2015-01-01

    Many inventory control studies consider either continuous review and continuous ordering, or periodic review and periodic ordering. Mixtures of the two are hardly ever studied. However, the model with periodic review and continuous ordering is highly relevant in practice, as information on the actua

  16. Periodic review and continuous ordering

    NARCIS (Netherlands)

    Prak, Dennis R.J.; Teunter, Ruud; Riezebos, Jan

    2014-01-01

    There exist many inventory control studies that consider either continuous review & continuous ordering, or periodic review & periodic ordering. Mixtures of the two are hardly ever studied. However, the model with periodic review and continuous ordering is highly relevant in practice, as information

  17. Periodic review and continuous ordering

    NARCIS (Netherlands)

    Prak, Dennis R.J.; Teunter, Ruud; Riezebos, Jan

    2014-01-01

    There exist many inventory control studies that consider either continuous review & continuous ordering, or periodic review & periodic ordering. Mixtures of the two are hardly ever studied. However, the model with periodic review and continuous ordering is highly relevant in practice, as information

  18. Periodic review and continuous ordering

    NARCIS (Netherlands)

    Prak, Dennis; Teunter, Ruud; Riezebos, Jan

    2015-01-01

    Many inventory control studies consider either continuous review and continuous ordering, or periodic review and periodic ordering. Mixtures of the two are hardly ever studied. However, the model with periodic review and continuous ordering is highly relevant in practice, as information on the

  19. Midy's Theorem for Periodic Decimals

    OpenAIRE

    Lewittes, Joseph

    2006-01-01

    The decimal expansion of 1/7 is 0.142857142857..., the block 142857 repeating forever. We call 142857 the period and its length is 6 = 2x3. If the period is broken into 2 pieces each of length 3 which are then added, the result is 142 + 857 = 999; similarly 14 + 28 + 57 = 99. Other periodic decimals show the same phenomenon while others do not. The general question then arises: Let a/N be a fraction with denominator prime to 10, having decimal expansion with period length dk, if the period is...

  20. Nonparametric Inference for Periodic Sequences

    KAUST Repository

    Sun, Ying

    2012-02-01

    This article proposes a nonparametric method for estimating the period and values of a periodic sequence when the data are evenly spaced in time. The period is estimated by a "leave-out-one-cycle" version of cross-validation (CV) and complements the periodogram, a widely used tool for period estimation. The CV method is computationally simple and implicitly penalizes multiples of the smallest period, leading to a "virtually" consistent estimator of integer periods. This estimator is investigated both theoretically and by simulation.We also propose a nonparametric test of the null hypothesis that the data have constantmean against the alternative that the sequence of means is periodic. Finally, our methodology is demonstrated on three well-known time series: the sunspots and lynx trapping data, and the El Niño series of sea surface temperatures. © 2012 American Statistical Association and the American Society for Quality.

  1. Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP).

    Science.gov (United States)

    De Nardis, Camilla; Lössl, Philip; van den Biggelaar, Maartje; Madoori, Pramod K; Leloup, Nadia; Mertens, Koen; Heck, Albert J R; Gros, Piet

    2017-01-20

    LDL receptor-related protein 1 (LRP1) is a highly modular protein and the largest known mammalian endocytic receptor. LRP1 binds and internalizes many plasma components, playing multiple crucial roles as a scavenger and signaling molecule. One major challenge to studying LRP1 has been that it is difficult to express such a large, highly glycosylated, and cysteine-rich protein, limiting structural studies to LRP1 fragments. Here, we report the first recombinant expression of the complete 61 domains of the full-length LRP1 ectodomain. This advance was achieved with a multistep cloning approach and by using DNA dilutions to improve protein yields. We investigated the binding properties of LRP1 using receptor-associated protein (RAP) as a model ligand due to its tight binding interaction. The LRP1 conformation was studied in its bound and unbound state using mass spectrometry, small-angle X-ray scattering, and negative-stain electron microscopy at neutral and acidic pH. Our findings revealed a pH-dependent release of the ligand associated with a conformational change of the receptor. In summary, this investigation of the complete LRP1 ectodomain significantly advances our understanding of this important receptor and provides the basis for further elucidating the mechanism of action of LRP1 in a whole and integrated system. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  2. Inhibition of interleukin-1β-mediated interleukin-1 receptor-associated kinase 4 phosphorylation by zinc leads to repression of memory T helper type 17 response in humans.

    Science.gov (United States)

    Lee, Hyunju; Kim, Bonah; Choi, Yeon Ho; Hwang, Yuri; Kim, Dong Hyun; Cho, Sunjung; Hong, Sung Jun; Lee, Won-Woo

    2015-12-01

    Zinc is an essential trace element that plays pivotal roles in multiple facets of the immune system. Besides its catalytic and structural roles, zinc also functions as an intracellular signalling molecule, and changes in zinc levels can cause both direct and indirect modulation of immune responses. Further, cytoplasmic levels of bioavailable zinc in immune cells are largely influenced by many extracellular stimuli. Here we provide evidence that zinc represses memory T helper type 17 responses in humans by inhibiting interleukin-1β (IL-1β)-mediated signal. In vitro zinc treatment of CD4(+) T cells in the presence of activated monocytes inhibited interferon-γ-producing cells and IL-17-producing cells, but not IL-4-producing cells. Of note, production of IL-17(+) cells from memory CD4(+) T cells, which is significantly up-regulated by lipopolysaccharide-stimulated monocytes, was preferentially repressed by zinc. Increased cytoplasmic zinc in T cells suppressed IL-1β signalling through repression of phosphorylation of IL-1 receptor-associated kinase 4 (IRAK4), so leading to an inhibitory effect on T helper type 17 responses facilitated by monocyte-derived IL-1β in humans. These findings suggest that extracellular zinc bioavailability may affect memory CD4(+) T-cell responses by modulating the zinc-mediated signalling pathway.

  3. Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain.

    Science.gov (United States)

    Prasad, Joni M; Migliorini, Mary; Galisteo, Rebeca; Strickland, Dudley K

    2015-07-10

    The low density lipoprotein receptor-related protein 1 (LRP1) is a member of the low density lipoprotein receptor family and plays important roles in a number of physiological and pathological processes. Expression of LRP1 requires the receptor-associated protein (RAP), a molecular chaperone that binds LRP1 and other low density lipoprotein receptor family members in the endoplasmic reticulum and traffics with them to the Golgi where the acidic environment causes its dissociation. Exogenously added RAP is a potent LRP1 antagonist and binds to LRP1 on the cell surface, preventing ligands from binding. Following endocytosis, RAP dissociates in the acidic endosome, allowing LRP1 to recycle back to the cell surface. The acid-induced dissociation of RAP is mediated by its D3 domain, a relatively unstable three-helical bundle that denatures at pH RAP D3 domain. By combining this disulfide bond with elimination of key histidine residues, we generated a stable RAP molecule that is resistant to both pH- and heat-induced denaturation. This molecule bound to LRP1 with high affinity at both neutral and acidic pH and proved to be a potent inhibitor of LRP1 function both in vitro and in vivo, suggesting that our stable RAP molecule may be useful in multiple pathological settings where LRP1 blockade has been shown to be effective. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  4. Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain*

    Science.gov (United States)

    Prasad, Joni M.; Migliorini, Mary; Galisteo, Rebeca; Strickland, Dudley K.

    2015-01-01

    The low density lipoprotein receptor-related protein 1 (LRP1) is a member of the low density lipoprotein receptor family and plays important roles in a number of physiological and pathological processes. Expression of LRP1 requires the receptor-associated protein (RAP), a molecular chaperone that binds LRP1 and other low density lipoprotein receptor family members in the endoplasmic reticulum and traffics with them to the Golgi where the acidic environment causes its dissociation. Exogenously added RAP is a potent LRP1 antagonist and binds to LRP1 on the cell surface, preventing ligands from binding. Following endocytosis, RAP dissociates in the acidic endosome, allowing LRP1 to recycle back to the cell surface. The acid-induced dissociation of RAP is mediated by its D3 domain, a relatively unstable three-helical bundle that denatures at pH RAP D3 domain. By combining this disulfide bond with elimination of key histidine residues, we generated a stable RAP molecule that is resistant to both pH- and heat-induced denaturation. This molecule bound to LRP1 with high affinity at both neutral and acidic pH and proved to be a potent inhibitor of LRP1 function both in vitro and in vivo, suggesting that our stable RAP molecule may be useful in multiple pathological settings where LRP1 blockade has been shown to be effective. PMID:26013822

  5. Analysis of risk factors and prognosis of pneumonia in elderly patients of cerebral stroke sequelae period%老年脑卒中患者后遗症期反复并发肺炎的危险因素及预后分析

    Institute of Scientific and Technical Information of China (English)

    王惠芳; 王惠民

    2013-01-01

    Objective To investigate the risk factors and prognosis of pneumonia in elderly patients of cerebral stroke sequelae period.Methods Eighty-eight cases of pneumonia in elderly patients with cerebral stroke sequelae period were selected as stroke group,with non-stroke patients of the same period suffering from pneumonia 1 ∶ 1 matched as control group.The risk factors and prognosis of pneumonia in elderly patients of cerebral stroke sequelae period were analyzed.Results Pneumonia in stroke group was related with hypertension,diabetes,conscious disturbance,bucking or nasogastric feeding,dyscinesia,incision of trachea,multiple organ disfunction syndrome (MODS),hospitalizations,hospital stay and abandon treatment or death (P < 0.05),and not related with smoking,coronary heart disease,kindey dysfunction,malignant tumor,phlegm bacterial culture,hypoxemia and mechanical ventilation was tested by conditioned Logistic regression quantitatively(P> 0.05).The independent risk factors for pneumonia in elderly patients of cerebral stroke sequelae period were bucking or nasogastric feeding,and MODS by two-way unconditional Logistic regression.Conclusions Hypertension,diabetes,conscious disturbance,bucking or nasogastric feeding,dyscinesia,incision of trachea,MODS,hospitalizations are risk factors for pneumonia in elderly patients of cerebral stroke sequelae period,and lead to relatively poor prognosis.Three-grade prevention and control of risk factors can improve prognosis.%目的 分析老年脑卒中患者后遗症期反复并发肺炎的危险因素与预后.方法 选择老年脑卒中后遗症期反复并发肺炎的患者作为脑卒中组,与同期住院的非脑卒中老年肺炎患者1∶1配对,组成对照组,分析老年脑卒中患者后遗症期反复并发肺炎的危险因素及预后.结果 脑卒中组反复并发肺炎与高血压、糖尿病、意识障碍、呛咳与鼻饲、肢体运动障碍、气管切开、多器官功能障碍综合征(MODS)、住

  6. Positive periodic solutions of delayed periodic Lotka-Volterra systems

    Energy Technology Data Exchange (ETDEWEB)

    Lin Wei [Laboratory of Nonlinear Mathematics Science, Institute of Mathematics, Fudan University, Shanghai 200433 (China)]. E-mail: weilin@fudan.edu.cn; Chen Tianping [Laboratory of Nonlinear Mathematics Science, Institute of Mathematics, Fudan University, Shanghai 200433 (China)]. E-mail: tchen@fudan.edu.cn

    2005-01-17

    In this Letter, for a general class of delayed periodic Lotka-Volterra systems, we prove some new results on the existence of positive periodic solutions by Schauder's fixed point theorem. The global asymptotical stability of positive periodic solutions is discussed further, and conditions for exponential convergence are given. The conditions we obtained are weaker than the previously known ones and can be easily reduced to several special cases.

  7. Risk factors for urinary tract infections in patients with lumbar spinal cord injuries during rehabilitation period%腰椎脊髓损伤患者康复期医院尿路感染的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    万春霞; 刘静; 杨春霞

    2015-01-01

    目的:探讨腰椎脊髓损伤患者康复期医院尿路感染的相关危险因素,对患者康复期治疗及尿路感染的预防起到一定指导作用。方法回顾性分析2012年6月-2013年6月62例腰椎脊髓损伤住院患者的临床资料,选择可能导致尿路感染的因素,比较尿路感染发生率,单因素分析影响尿路感染发生的相关因素,多因素 logistic回归分析影响尿路感染发生的独立危险因素。结果脊髓损伤患者发生尿路感染27例,感染率为43.5%;脊髓损伤程度、尿管留置时间、膀胱冲洗频率、尿路感染前抗菌药物使用、有低蛋白血症是影响脊髓损伤住院患者康复期尿路感染的危险因素;脊髓损伤程度、尿管留置时间和尿路感染前使用抗菌药物是影响脊髓损伤住院患者康复期尿路感染发生的独立危险因素。结论采取相应的预防措施,可有效地减少患者尿路感染的发生率,提高患者康复期间的治疗效果。%OBJECTIVE To explore the related risk factors for nosocomial infections in patients with lumbar spinal cord injuries during the rehabilitation period so as to provide guidance for prevention of urinary tract infections during the rehabilitation period .METHODS The clinical data of 62 patients with lumbar spinal cord injuries who were hospitalized from Jun 2012 to Jun 2013 were retrospectively analyzed ,then the risk factors for the urinary tract infections were analyzed ,the incidence of the urinary tract infections was observed ,the univariate analysis was conducted for the related influencing factors for the urinary tract infections ,and the multivariate logistic re‐gression analysis was performed for the independent risk factors for the urinary tract infections .RESULTS The uri‐nary tract infections occurred in 27 patients with spinal cord injuries ,with the infection rate of 43 .5% .The degree of spinal cord injuries ,catheter indwelling time ,frequency

  8. Policy Uncertainty, Investment and Commitment Periods

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-07-01

    Today's investment decisions in key sectors such as energy, forestry or transport have significant impacts on the levels of greenhouse gas (GHG) emissions over the coming decades. Given the economic and environmental long-term implications of capital investment and retirement, a climate mitigation regime should aim to encourage capital investment in climate-friendly technologies. Many factors affect technology choice and the timing of investment, including investor expectations about future prices and policies. Recent international discussions have focused on the importance of providing more certainty about future climate policy stringency. The design of commitment periods can play a role in creating this environment. This paper assesses how the length of commitment periods influences policy uncertainty and investment decisions. In particular, the paper analyses the relationship between commitment period length and near term investment decisions in climate friendly technology.

  9. [Periodic breathing with periodic oxygen variation in infancy].

    Science.gov (United States)

    von Czettritz, G; Bax, R T; Eckardt, T; Springer, S; Emmrich, P

    1996-01-01

    Oxycardiorespirographies, recording arterial oxygen saturation (SaO2), breathing movements, heart rate and ECG with a mean recording time of 22.3 hours, were performed on 85 preterm (mean postconceptional age: 38 weeks) and 81 term infants (mean postconceptional age 42.4 weeks). 83% of the preterm infants showed periodic breathing (PB), in 97% of them this was accompanied by periodic variations of arterial oxygen saturation (PVO). Periodic breathing occurred in 61% of the term infants, 84% of them showed PVO during periodic breathing. The mean variation of oxygen saturation was between 92.8 and 96.8% (+/- 1.7) for preterm and between 92.9 and 96.0% (+/- 2.2) for term infants. In some infants the peak to peak amplitude of the SaO2 cycles was up to 22%, sometimes a further fall of SaO2 occurred. There was a strong correlation of the PVO both at the beginning and end of the episode as well as with the PB-cycle periodicity itself. The fall of the oxygen saturation occurred 3.1 to 7.8 s after the beginning of the first apnea of an episode of periodic breathing, the minimum SaO2 was reached approximately 4.2 to 8.6 s later. This periodic rapid fall of SaO2 from a high oxygenation level cannot be explained by the apneas of a rather short duration during periodic breathing. It is discussed that PVO during periodic breathing may be caused by an ideopathic right to left shunting across fetal circulation pathways which occurs intermittently and periodically. This mechanism could-via patterns of reaction exhibited during the fetal and neonatal time period-lead to acute hypoxemia, as found in apparently life threatening events (ALTE) and as postulated in sudden infant death (SID).

  10. Repelling periodic points of given periods of rational functions

    Institute of Scientific and Technical Information of China (English)

    CHANG Jianming; FANG Mingliang

    2006-01-01

    Let R(z) be a rational function of degree d ≥ 2. Then R(z) has at least one repelling periodic point of given period k ≥ 2, unless k = 4 and d=2, or k= 3 and d ≤ 3, or k=2 and d≤8. Examples show that all exceptional cases occur.

  11. From Periodic Properties to a Periodic Table Arrangement

    Science.gov (United States)

    Besalú, Emili

    2013-01-01

    A periodic table is constructed from the consideration of periodic properties and the application of the principal components analysis technique. This procedure is useful for objects classification and data reduction and has been used in the field of chemistry for many applications, such as lanthanides, molecules, or conformers classification.…

  12. From Periodic Properties to a Periodic Table Arrangement

    Science.gov (United States)

    Besalú, Emili

    2013-01-01

    A periodic table is constructed from the consideration of periodic properties and the application of the principal components analysis technique. This procedure is useful for objects classification and data reduction and has been used in the field of chemistry for many applications, such as lanthanides, molecules, or conformers classification.…

  13. On the Period-Amplitude and Amplitude-Period Relationships

    Science.gov (United States)

    Wilson, Robert M.; Hathaway, David H.

    2008-01-01

    Examined are Period-Amplitude and Amplitude-Period relationships based on the cyclic behavior of the 12-month moving averages of monthly mean sunspot numbers for cycles 0.23, both in terms of Fisher's exact tests for 2x2 contingency tables and linear regression analyses. Concerning the Period-Amplitude relationship (same cycle), because cycle 23's maximum amplitude is known to be 120.8, the inferred regressions (90-percent prediction intervals) suggest that its period will be 131 +/- 24 months (using all cycles) or 131 +/- 18 months (ignoring cycles 2 and 4, which have the extremes of period, 108 and 164 months, respectively). Because cycle 23 has already persisted for 142 months (May 1996 through February 2008), based on the latter prediction, it should end before September 2008. Concerning the Amplitude-Period relationship (following cycle maximum amplitude versus preceding cycle period), because cycle 23's period is known to be at least 142 months, the inferred regressions (90-percent prediction intervals) suggest that cycle 24's maximum amplitude will be about less than or equal to 96.1 +/- 55.0 (using all cycle pairs) or less than or equal to 91.0 +/- 36.7 (ignoring statistical outlier cycle pairs). Hence, cycle 24's maximum amplitude is expected to be less than 151, perhaps even less than 128, unless cycle pair 23/24 proves to be a statistical outlier.

  14. Research data supporting "Jastrow correlation factor for periodic systems"

    OpenAIRE

    Whitehead, Thomas M.; Michael, Marios H.; Conduit, Gareth J.

    2016-01-01

    tar.gz archive: contains plain text files, some for use in CASINO quantum Monte Carlo simulations, some containing shell or gnuplot scripts, and Mathematica .nb notebooks, as well as data files with associated READMEs. EPSRC [EP/J017639/1] Royal Society Gonville & Caius College

  15. Factors influencing resilience in patients with burns during rehabilitation period

    Directory of Open Access Journals (Sweden)

    Zhen Yang

    2014-03-01

    Conclusion: During psychological crisis intervention, medical staff should guide burn patients according to their individual coping styles. Such guidance would achieve a better effect, improve patient resilience, and promote positive psychological adaptation.

  16. Estudo médico-social dos fatores contribuintes para os acidentes das aeronaves executivas convencionais registrados entre 1971 e 1975, no Estado de São Paulo, Brasil: I - Época e hora da ocorrência e principal fator contribuinte Medico-social study of factors related to aircraft accidents with light planes occurred during the period of 1971 to 1975, S. Paulo, Brazil: I - The month and hour of the occurrence and the principal contributing factor

    Directory of Open Access Journals (Sweden)

    Affonso Renato Meira

    1978-06-01

    Full Text Available Em estudo sobre os acidentes aeronáuticos ocorridos de 1971 à 1975 com aeronaves executivas convencionais na área do IV Comando Aéreo Regional, foram analisados diversos fatores contribuintes para esse fato. Foram examinados a época da ocorrência e o principal fator contribuinte, concluindo-se que o período do dia em que se verificou maior número de acidentes foi à tarde entre 14 e 18 h., e que o fator operacional, devido ao piloto, está associado estatisticamente com a ocorrência dos acidentes. Não foi possível comprovar maior índice de ocorrência de acidentes com referência aos meses do ano.Studying the aircraft accidents occurred with light planes during the period of 1971 to 1975 in the area of the IV Comar in the State of S. Paulo, Brazil, several factors related with accidents were analyzed. Among these the month and hour of the occurrence and the principal factor that contributed to the accident were studied. It was found that the majorit of the aircraft accidents occurred from 2 P.M. to 6 P.M. and that the main factor that contributed to the occurrence of the accidents was linked with the pilots' attitudes. It was not possible to establish an association of the accident with the month of occurrence.

  17. Latino Periodicals: A Selection Guide.

    Science.gov (United States)

    Guerena, Salvador, Ed.; Pisano, Vivian M., Ed.

    This guide is a collection development tool of national scope for librarians who need in-depth coverage of Latino periodicals suitable for public, school, and academic libraries. Periodicals evaluated include general interest and popular magazines and newspapers that appeal to Spanish-speaking, bilingual, and English-speaking library patrons and…

  18. Epitope Mapping of Antibodies Suggests the Novel Membrane Topology of B-Cell Receptor Associated Protein 31 on the Cell Surface of Embryonic Stem Cells: The Novel Membrane Topology of BAP31.

    Directory of Open Access Journals (Sweden)

    Won-Tae Kim

    Full Text Available When located in the endoplasmic reticulum (ER membrane, B-cell receptor associated protein 31 (BAP31 is involved in the export of secreted proteins from the ER to the plasma membrane. In a previous study, we generated two monoclonal antibodies (mAbs, 297-D4 and 144-A8, that bound to surface molecules on human embryonic stem cells (hESCs, but not to surface molecules on mouse embryonic stem cells (mESCs. Subsequent studies revealed that the mAbs recognized BAP31 on the surface of hESCs. To investigate the membrane topology of BAP31 on the cell surface, we first examined the epitope specificity of 297-D4 and 144-A8, as well as a polyclonal anti-BAP31 antibody (α-BAP31. We generated a series of GST-fused BAP31 mutant proteins in which BAP31 was serially deleted at the C- terminus. GST-fused BAP31 mutant proteins were then screened to identify the epitopes targeted by the antibodies. Both 297-D4 and 144-A8 recognized C-terminal residues 208-217, while α-BAP31 recognized C-terminal residues 165-246, of BAP31 on hESCs, suggesting that the C-terminal domain of BAP31 is exposed on the cell surface. The polyclonal antibody α-BAP31 bound to mESCs, which confirmed that the C-terminal domain of BAP31 is also exposed on the surface of these cells. Our results show for the first time the novel membrane topology of cell surface-expressed BAP31 as the extracellular exposure of the BAP31 C-terminal domain was not predicted from previous studies.

  19. Epitope Mapping of Antibodies Suggests the Novel Membrane Topology of B-Cell Receptor Associated Protein 31 on the Cell Surface of Embryonic Stem Cells: The Novel Membrane Topology of BAP31.

    Science.gov (United States)

    Kim, Won-Tae; Choi, Hong Seo; Hwang, Hyo Jeong; Jung, Han-Sung; Ryu, Chun Jeih

    2015-01-01

    When located in the endoplasmic reticulum (ER) membrane, B-cell receptor associated protein 31 (BAP31) is involved in the export of secreted proteins from the ER to the plasma membrane. In a previous study, we generated two monoclonal antibodies (mAbs), 297-D4 and 144-A8, that bound to surface molecules on human embryonic stem cells (hESCs), but not to surface molecules on mouse embryonic stem cells (mESCs). Subsequent studies revealed that the mAbs recognized BAP31 on the surface of hESCs. To investigate the membrane topology of BAP31 on the cell surface, we first examined the epitope specificity of 297-D4 and 144-A8, as well as a polyclonal anti-BAP31 antibody (α-BAP31). We generated a series of GST-fused BAP31 mutant proteins in which BAP31 was serially deleted at the C- terminus. GST-fused BAP31 mutant proteins were then screened to identify the epitopes targeted by the antibodies. Both 297-D4 and 144-A8 recognized C-terminal residues 208-217, while α-BAP31 recognized C-terminal residues 165-246, of BAP31 on hESCs, suggesting that the C-terminal domain of BAP31 is exposed on the cell surface. The polyclonal antibody α-BAP31 bound to mESCs, which confirmed that the C-terminal domain of BAP31 is also exposed on the surface of these cells. Our results show for the first time the novel membrane topology of cell surface-expressed BAP31 as the extracellular exposure of the BAP31 C-terminal domain was not predicted from previous studies.

  20. Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP.

    Science.gov (United States)

    Jensen, Jan K; Dolmer, Klavs; Schar, Christine; Gettins, Peter G W

    2009-06-26

    RAP (receptor-associated protein) is a three domain 38 kDa ER (endoplasmic reticulum)-resident protein that is a chaperone for the LRP (low-density lipoprotein receptor-related protein). Whereas RAP is known to compete for binding of all known LRP ligands, neither the location, the number of binding sites on LRP, nor the domains of RAP involved in binding is known with certainty. We have systematically examined the binding of each of the three RAP domains (D1, D2 and D3) to tandem and triple CRs (complement-like repeats) that span the principal ligand-binding region, cluster II, of LRP. We found that D3 binds with low nanomolar affinity to all (CR)2 species examined. Addition of a third CR domain increases the affinity for D3 slightly. A pH change from 7.4 to 5.5 gave only a 6-fold increase in Kd for D3 at 37 degrees C, whereas temperature change from 22 degrees C to 37 degrees C has a similar small effect on affinity, raising questions about the recently proposed D3-destabilization mechanism of RAP release from LRP. Surprisingly, and in contrast to literature suggestions, D1 and D2 also bind to most (CR)2 and (CR)3 constructs with nanomolar affinity. Although this suggested that there might be three high-affinity binding sites in RAP for LRP, studies with intact RAP showed that only two binding sites are available in the intact chaperone. These findings suggest a new model for RAP to function as a folding chaperone and also for the involvement of YWTD domains in RAP release from LRP in the Golgi.

  1. ANÁLISIS DEL ÍNDICE DE IMPACTO EN LA ESPECIALIDAD DE CARDIOLOGÍA SEGÚN EL JOURNAL CITATION REPORTS EN EL PERÍODO 2006-2008 / Analysis of the impact factor in cardiology according to the Journal Citation Reports during the period 2006-2008

    Directory of Open Access Journals (Sweden)

    Yenni González Lugo

    2010-03-01

    Full Text Available Heart diseases are at the top of the health statistics concerning the main causes of death in the world. This fact reveals the need of focussing the health scientific policy toward the diagnosis and treatment of these diseases. Currently, the best results in this field are not widely published; however, the challenge for Cuban publications, in general, is to reach a better visibility. In order to meet this challenge, a bibliometric study of the Cardiology journals which are available in the Web of Science was carried out, having the Impact Factor (IF as the main variable. The issues of the JCR Science Edition during the period from 2006 to 2008 were analysed. The results showed that there is not a sufficient amount of journals on this field, in spite of the fact that there is a group which has increased its number, year after year, with a relatively high impact factor. Although the vast majority of these journals are published in English, some others, of high renown, are published in Spanish or are multilingual. The Journal of the American College of Cardiology was the journal with the highest impact factor in 2008; therefore, it is the one with the highest visibility in this specialty. Finally, it was determined that most of the Cardiology journals are from North America, mainly from the US, while only 6 of them are from Europe.

  2. Analysis of influencing factors of self care ability of patients with radical cystectomy double ureter skin colostomy at different periods after discharge%膀胱全切并双输尿管皮肤造口病人出院后不同时期自我护理能力的影响因素分析

    Institute of Scientific and Technical Information of China (English)

    袁源; 郑瑾

    2015-01-01

    [目的]探讨膀胱全切并双输尿管皮肤造口病人出院后不同时期自我护理能力的影响因素。[方法]采取问卷调查的方法,应用自我护理能力测定量表(ESCA)对病人不同阶段自我护理能力进行测评,并分析影响病人自我护理能力的因素。[结果]多元逐步回归分析显示,性别、年龄、婚姻状况、饮酒状况、文化程度、职业、个人月收入、主观支持和客观支持在病人出院时及出院后不同时期对病人的自我护理能力的不同维度产生影响。[结论]病人自我护理能力的不同维度在病人出院后不同时期受到不同因素的影响。护理人员在病人出院后不同时期,应为病人制定具有针对性的健康教育方案,从而进一步提高病人的自我护理能力,提高生命质量。%Objective:To probe into the influencing factors of self care ability of patients with radical cystecto-my double ureter skin colostomy at different periods after discharge.Methods:The questionnaire survey was used and the exercise of self care agency scale(ESCA)was applied to evaluate the self care ability of patients at different stages,and analyzed the influencing factors of the self care ability of patients.Results:Multivariate stepwise regression analysis showed that the factors with statistical significance included the gender,age,marital status,alcohol consumption,education level,occupation,personal monthly income,subjective support and objec-tive support.These 9 factors had an effect on the different dimensions of the patients’self care ability at dif-ferent periods at discharge and after discharge.Conclusion:The different dimensions of patients’self care abili-ty were affected by different factors at different periods of patients after discharge.The results showed that the nursing personnel should have a specific health education program for the patients at different periods after dis-charge,so as to further improve the

  3. This research is to study the factors which influence the business success of small business ‘processed rotan’. The data employed in the study are primary data within the period of July to August 2013, 30 research observations through census method. Method of analysis used in the study is multiple linear regressions. The results of analysis showed that the factors of labor, innovation and promotion have positive and significant influence on the business success of small business ‘processed rotan’ simultaneously. The analysis also showed that partially labor has positive and significant influence on the business success, yet innovation and promotion have insignificant and positive influence on the business success.

    OpenAIRE

    Nasution, Inggrita Gusti Sari; Muchtar, Yasmin Chairunnisa

    2013-01-01

    This research is to study the factors which influence the business success of small business ‘processed rotan’. The data employed in the study are primary data within the period of July to August 2013, 30 research observations through census method. Method of analysis used in the study is multiple linear regressions. The results of analysis showed that the factors of labor, innovation and promotion have positive and significant influence on the business success of small busine...

  4. Optical Periodicity Analysis of 3C 446 using Period04

    Indian Academy of Sciences (India)

    Fei Guo; Hao Jing Zhang

    2014-09-01

    All the data of the blazar 3C446 at 8, 4.8, 14 and 22 GHz, presented in publications from 1977 to 2006, have been compiled to generate light curves. The light curves show violent activity of 3C446. Using Period04 analysis method, we have found that there is a period of 7.2 yr, which is consistent with the results that we found using wavelet analysis method. We get the instability region as = 123.83.

  5. The Periodic Table in Croatia

    Directory of Open Access Journals (Sweden)

    Raos, N.

    2011-12-01

    Full Text Available The Croatian (Yugoslav Academy of Sciences and Arts was the first academy to elect D. I. Mendeleev as its honorary member (1882, whereas the periodic table of the elements has been taught regularly at the Zagreb University since 1888. The early interest of Croatian chemists in the periodic table should be attributed primarily to their pan-Slavic attitude, particularly as proof that Slavic people were able to produce "their own Newtons" (M. V. Lomonosov and D. I. Mendeleev. Such enthusiastic views, however, did not help in analyzing the contribution of Mendeleev and other scientists to the discovery and development of the periodic table of the elements.

  6. Periodic insolation variations on Mars.

    Science.gov (United States)

    Murray, B C; Ward, W R; Yeung, S C

    1973-05-11

    Previously unrecognized insolation variations on Mars are a consequence of periodic variations in eccentricity, first established by the theory of Brouwer and Van Woerkom (1950). Such annual insolation variations, characterized by both 95,000-year and 2,000,000-year periodicities, may actually be recorded in newly discovered layered deposits in the polar regions of Mars. An additional north-south variation in seasonal insolation, but not average annual insolation, exists with 51,000-year and 2,000,000-year periodicities.

  7. DVT high risk factors analysis in gynecological perioperative period and evaluation of the prevention value of the clinical application of nodroparin%妇科围手术期DVT高危因素分析及速碧林临床应用预防价值评价

    Institute of Scientific and Technical Information of China (English)

    刘惠莉

    2016-01-01

    Objective: To investigate the high risk factors of deep venous thrombosis (DVT) in gynecological perioperative period and to evaluate the prevention value of the clinical application of nodroparin. Methods: 40 patients with DVT, treated in our hospital from December 2012 to October 2015, were selected as the research objects and retrospectively analyzed; all patients received nodroparin as preventive treatment. Results: DVT was high risk factor in gynecological perioperative period, single factor analysis indicated that the incidence of DVT was related to factors such as malignant tumor, preventive measures, long braking time, long operation time, bleeding volume during operation, perioperative blood transfusion, the above single factor analysis was of statistical difference (P0.05). Conclusion:DVT was high risk factor in gynecological perioperative period, nodroparin could prevent DVT effectively, it was of high security and could relieve the patient's symptoms significantly, therefore, it was worthy of clinical promotion and application.%目的:探讨妇科围手术期深静脉血栓形成(Deep Venous Thrombosis,DVT)高危因素分析及速碧林临床应用预防价值。方法:回顾性分析2012年9月—2015年10月于我院妇产科治疗的40例高危患者为研究对象,对全部患者使用速碧林预防治疗。结果:深静脉血栓是妇科围手术期高危因素,经单因素分析,深静脉血栓的发生与恶性肿瘤、预防措施、制动时间长、手术时间过长、术中出血量多、围术期输血量大等因素有关,以上单因素分析差异有统计学意义(P<0.05)。将研究患者分为4个等级,低危、中危、高危与极高危,按患者等级进行速碧林注射治疗,治疗后患者发生率、并发症,差异无统计学意义(P>0.05)。结论:深静脉血栓是妇科围手术期 DVT 高危因素,速碧林能有效预防深静脉血栓,安全性高、状况明显改善,值得临床推广应用。

  8. Biologia reprodutiva de Micropogonias furnieri (Desmarest, 1823 (Teleostei, Sciaenidae: 1. fator de condição como indicador do período de desova The reproductive biology of Micropogonias furnieri (Desmarest, 1823 (Teleostei, Sciaenidae: 1. condition factor as an indicator of spawning period

    Directory of Open Access Journals (Sweden)

    Victoria Judith Isaac-Nahum

    1983-01-01

    Full Text Available A analise temporal da freqüência de estádios de maturação de 102 fêmeas adultas coletadas entre fevereiro de 1979 e janeiro de 1980 na região de Ubatuba, litoral norte do Estado de São Paulo, mostra que M. funieri, nessa área, apresenta três desovas durante o ano: uma no outono (abril-junho, outra no inverno (agosto-setembro e uma terceira na primavera-verão (novembro-fevereiro. Essa sugestão e reforçada pelas flutuações de K (fator de condição considerando-se o peso das gonadas e K' (sem considerar o peso das gonadas, durante um ciclo reprodutivo. Os valores máximos de K e K' coincidem com os picos de ocorrencia de indivíduos com gonadas maturas (C e, os mínimos, com os de indivíduos com gonadas esvaziadas (D, A diferença entre K e K' (AR estima a "condição da gonada" apresentando seus máximos nos períodos de mais intensa atividade dos ovários, contituindo-se, assim, o valor de AK em um índice indireto de maturidade e dos períodos de desova de M. funieri.The monthly analysis of maturity stage frequency of adult females caught monthly at the Ubatvíba region, SP, from February 1979 to January 1980, suggests that M. funieri spaws three times ayear: Autumn (April-June , Winter (August-Sept ember and Spring-Summer (November-February. Condition factor fluctuations estimated with andwithout gonads K and K' during a reproductive cycle reinforces hypothesis0 K and K' maximum values relate precisely with higher frequency periods of a females at advanced stages of maturity (C. On the other hand, K and K' minimum values are concomitant with higher frequency periods of spent females (D. Although K and K' have a similar evolution, there are some periods in which ΔK (K-K' appears higher: May, August-September and November. These periods are also related to the maximum frequency of females in stage C. As AX estimes the "gonad condition", establishing the periods when the gonad attains the maximum weight in relation to body weight

  9. 75 FR 1301 - Periodic Reporting

    Science.gov (United States)

    2010-01-11

    ... From the Federal Register Online via the Government Publishing Office POSTAL REGULATORY COMMISSION 39 CFR Part 3050 Periodic Reporting AGENCY: Postal Regulatory Commission. ACTION: Proposed rule; notice of availability of rulemaking petition. SUMMARY: The Postal Service has proposed adjustments to...

  10. Measuring Scars of Periodic Orbits

    CERN Document Server

    Kaplan, L

    1999-01-01

    The phenomenon of periodic orbit scarring of eigenstates of classically chaotic systems is attracting increasing attention. Scarring is one of the most important ``corrections'' to the ideal random eigenstates suggested by random matrix theory. This paper discusses measures of scars and in so doing also tries to clarify the concepts and effects of eigenfunction scarring. We propose a new, universal scar measure which takes into account an entire periodic orbit and the linearized dynamics in its vicinity. This measure is tuned to pick out those structures which are induced in quantum eigenstates by unstable periodic orbits and their manifolds. It gives enhanced scarring strength as measured by eigenstate overlaps and inverse participation ratios, especially for longer orbits. We also discuss off-resonance scars which appear naturally on either side of an unstable periodic orbit.

  11. Autism: a "critical period" disorder?

    Science.gov (United States)

    LeBlanc, Jocelyn J; Fagiolini, Michela

    2011-01-01

    Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic neurodevelopmental disorder diagnosed by abnormal socialization, impaired communication, and repetitive behaviors or restricted interests. The underlying cause is still largely unknown and there is no fully effective treatment or cure. We propose that alteration of the expression and/or timing of critical period circuit refinement in primary sensory brain areas may significantly contribute to autistic phenotypes, including cognitive and behavioral impairments. Dissection of the cellular and molecular mechanisms governing well-established critical periods represents a powerful tool to identify new potential therapeutic targets to restore normal plasticity and function in affected neuronal circuits.

  12. Periodicities in photospheric magnetic flux

    Institute of Scientific and Technical Information of China (English)

    SONG; Wenbin; WANG; Jingxiu

    2006-01-01

    Magnetic field plays an important role in solar structure and activity. In principle, the determination of magnetic flux would provide the best general-purpose index of solar activity. Currently, the periodicity studies corresponding to photospheric magnetic flux (PMF) are very few possibly due to the absence of a uniform flux sequence. In this paper, by using 383 NSO/Kitt Peak magnetic synoptic charts we reconstruct a flux sequence from February 1975 to August 2003 and perform a relatively systemic periodicity analysis with two methods of the Scargle periodogram and the Morlet wavelet transform. As a result, four periods are found at around 1050, 500, 300 and 160 days. We analyze these periods' temporal variabilities in detail and discuss their respective origins briefly.

  13. Revisión de los condicionantes de la profesión periodística desde la perspectiva sociológica de McNair ¿Es viable un periodismo profesional de calidad?//An updated analysis of factors conditioning journalism from McNair’s sociological perspective. Is it feasible to perform quality journalism nowadays?

    Directory of Open Access Journals (Sweden)

    Roberto GELADO-MARCOS

    2016-07-01

    Full Text Available La actividad periodística se ha visto sometida en los últimos años a una transformación radical fundamentada, principalmente, aunque no sólo, en la revolución tecnológica que ha incrementado exponencialmente las posibilidades de unos medios además siguen lidiando con los condicionamientos procedentes de los entornos políticos, económicos, profesionales y sociales. Ante este nuevo escenario, se plantea una pregunta inmediata: ¿sigue resultando viable un periodismo profesional y de calidad con los condicionantes actuales? Este artículo trata de dar respuesta a la pregunta de investigación desde una revisión actualizada de la perspectiva sociológica sobre la que McNair analiza los factores que condicionan la profesión.

  14. Period Integrals and Tautological Systems

    CERN Document Server

    Lian, Bong H; Yau, Shing-Tung

    2011-01-01

    We study period integrals of CY hypersurfaces in a partial flag variety. We construct a holonomic system of differential equations which govern the period integrals. By means of representation theory, a set of generators of the system can be described explicitly. The results are also generalized to CY complete intersections. The construction of these new systems of differential equations have lead us to the notion of a tautological system.

  15. Period-doubling cascades galore

    OpenAIRE

    Sander, Evelyn; Yorke, James A.

    2009-01-01

    The appearance of numerous period-doubling cascades is among the most prominent features of {\\bf parametrized maps}, that is, smooth one-parameter families of maps $F:R \\times {\\mathfrak M} \\to {\\mathfrak M}$, where ${\\mathfrak M}$ is a smooth locally compact manifold without boundary, typically $R^N$. Each cascade has infinitely many period-doubling bifurcations, and it is typical to observe -- such as in all the examples we investigate here -- that whenever there are any cascades, there are...

  16. Periodic billiard trajectories in polyhedra

    CERN Document Server

    Bedaride, Nicolas

    2011-01-01

    We consider the billiard map inside a polyhedron. We give a condition for the stability of the periodic trajectories. We apply this result to the case of the tetrahedron. We deduce the existence of an open set of tetrahedra which have a periodic orbit of length four (generalization of Fagnano's orbit for triangles), moreover we can study completly the orbit of points along this coding.

  17. Jupiter and Saturn Rotation Periods

    CERN Document Server

    Helled, Ravit; Anderson, John D

    2009-01-01

    Anderson & Schubert (2007, Science,317,1384) proposed that Saturn's rotation period can be ascertained by minimizing the dynamic heights of the 100 mbar isosurface with respect to the geoid; they derived a rotation period of 10h 32m 35s. We investigate the same approach for Jupiter to see if the Jovian rotation period is predicted by minimizing the dynamical heights of its isobaric (1 bar pressure level) surface using zonal wind data. A rotation period of 9h 54m 29s is found. Further, we investigate the minimization method by fitting Pioneer and Voyager occultation radii for both Jupiter and Saturn. Rotation periods of 9h 55m 30s and 10h 32m 35s are found to minimize the dynamical heights for Jupiter and Saturn, respectively. Though there is no dynamical principle requiring the minimization of the dynamical heights of an isobaric surface, the successful application of the method to Jupiter lends support to its relevance for Saturn. We derive Jupiter and Saturn rotation periods using equilibrium theory in ...

  18. 甘肃省少数民族地区包容性增长制约因素分析——基于“十二五”的历史方位%Analysis about restrictive Factors in Minority Area of GanSu's Inclusive Growth --Based on the Historical Position of the Period from the Year 2011 to 2015

    Institute of Scientific and Technical Information of China (English)

    张克政

    2012-01-01

    包容性增长是“十二五”时期甘肃省少数民族地区发展面临的重大课题。经济基础薄弱、发展任务繁重、自然条件恶劣、地理区住劣势明显、基础设施落后、社会事业发展滞后、人才资源匮乏、制度不完善、社会不公是制约“十二五”时期少数民族地区包容性增长的主要因素。深入分析少数民族地区包容性增长的制约因素,是推动少数民族地区包容性增长的前提。%Inclusive growth is a great subject to minority area of GanSu in the period of the year 2011 to 2015. The unsubstantial economic foundation, heavy development task, bad natural conditions, evident geographical location disadvantages, behindhand infrastructure, hysteretic development of social undertakings, deficient resources of human talents, ineompletcd system and social injustice are major restrictive factors which will restrict minority area of Gansu's inclusive growth in the period from the year 2011 to 2015. In-depth analysis of the restrictive factors about minority area of GanSu's inclusive growth is the precondition of pushing forward minority area of GanSu's inclusive growth.

  19. The Short Rotation Period of Nereid

    CERN Document Server

    Grav, T; Kavelaars, J J

    2003-01-01

    We determine the period, p = 11.52 \\pm 0.14 h, and a light curve peak-to-peak amplitude, a = 0.029 \\pm 0.003 magnitudes, of the Neptunian irregular satellite Nereid. If the light curve variation is due to albedo variations across the surface, rather than solely to the shape of Nereid variations, the rotation period would be a factor of two shorter. In either case, such a rotation period and light curve amplitude, together with Nereid's orbital period, p=360.14 days, imply that Nereid is almost certainly in a regular rotation state, rather than the chaotic rotation state suggested by Schaefer and Schaefer (1988,2000) and Dobrovolskis (1995). Assuming that Nereid is perfectly spherical, the albedo variation is 3% across the observed surface. Assuming a uniform geometric albedo, the observed cross sectional area varies by 3%. We caution that the lightcurve found in this paper only sets limits on the combination of albedo and physical irregularity and that we cannot determine the orientation of Nereid's spin axis...

  20. Assessment of intelligence in the preschool period.

    Science.gov (United States)

    Baron, Ida Sue; Leonberger, Katherine Ann

    2012-12-01

    Intelligence testing has a long and revered history in psychological measurement in childhood. Yet, the years between infancy and early childhood have been understudied with respect to emergent intellectual and cognitive functioning. Factor analytic models of intelligence that have demonstrated applicability when testing older children and adults often appear inadequate in the preschool period. As more is learned about brain development in typically developing children during these crucial years the distinctive relationships between neural system development and intellectual functioning are being revealed more completely. The aim of this paper was to provide a brief historical background as a foundation for discussion of intelligence testing, review what is known about the dynamic course of brain development during the preschool years, acknowledge limitations specific to intelligence testing in young children, and provide support for maintaining a comprehensive neuropsychological perspective that considers the wider range of variables that influence intellectual functioning in the preschool period.

  1. Thyrotoxic Hypokalemic Periodic Paralysis: A Case Report

    Directory of Open Access Journals (Sweden)

    Murat Atmaca

    2012-12-01

    Full Text Available Thyrotoxic hypokalemic periodic paralysis is a rare complication of thyrotoxicosis. This clinic condition is often encountered in Asian populations and male gender while thyrotoxicosis is frequently seen in women. The escape of potassium into cell is the mechanism responsible for this disease and its etiology is not completely known. Thyroid hormones, carbohydrate rich diet, alcohol consumption and excessive exercise are regarded as the precipitating factors. This clinical picture is generally difficult to define at first attack. Here, we report a forty-two-year-old male patient with Basedow-Graves disease who was diagnosed as having thyrotoxic hypokalemic periodic paralysis during the first paralytic attack. His symptoms improved after potassium replacement and treatment with beta-blocker and antithyroid drugs. The permanent cure was achieved with radioactive iodine ablation therapy. Turk Jem 2012; 16: 69-71

  2. IMPORTANCE OF CRITICAL PERIOD OF WEED COMPETITION FOR CROP GROWING

    Directory of Open Access Journals (Sweden)

    Marijana Ivanek-Martinčić

    2010-06-01

    Full Text Available A concept of critical period of weed competition has been introduced for more than 40 years ago. The concept is based on the assumption that weeds are not equally harmful to a crop during the whole season and that there is a period in crop development in which weeds impact on the yield is the biggest. This period is called critical period of weed competition (CPWC, critical period of weed interference, or critical period of weed control. There is a difference in CPWC between crops, but CPWC for a certain crop can vary a lot because it depends on many factors which can affect the crop or weeds competition ability. The critical period of weed competition identification is essential for integrated weed control and precise planning of a weed control strategy as well as for rationale use of herbicides and other weed control measures.

  3. Periodic Sweep Coverage Scheme Based on Periodic Vehicle Routing Problem

    Directory of Open Access Journals (Sweden)

    Li Shu

    2014-03-01

    Full Text Available We provide a sweep coverage algorithm for routing mobile sensors that communicate with a central data sink. This algorithm improves on its predecessors by reducing the number of unnecessary scans when different points of interest (POIs have different requirements for the time interval within which they must be scanned (sweep period. Most sweep coverage algorithms seek to minimize the number of sensors required to cover a given collection of POIs. When POIs have different sweep period requirements, existing algorithms will produce solutions in which sensors visit some POIs much more frequently than is necessary. We define this as the POI Over-Coverage problem. In order to address this problem we develop a Periodic Sweep Coverage (PSC scheme based on a well-known solution to the Periodic Vehicle Routing Problem (PVRP. Our algorithm seeks a route for the mobile sensors that minimizes the number of unnecessary visits to each POI. To verify and test the proposed scheme we implemented a C++ simulation and ran scenarios with a variety of POI topologies (number and distribution of the POIs and the speed at which sensors could travel. The simulation results show that the PSC algorithm outperforms other sweep coverage algorithms such as CSweep and Vehicle Routing Problem Sweep Coverage (VRPSC on both the average number of sensors in a solution and in the computational time required to find a solution. Our results also demonstrate that the PSC scheme is more suitable for the sweep coverage scenarios in which higher speed mobile sensors are used.

  4. Computing partial-shift respirator use periods

    Energy Technology Data Exchange (ETDEWEB)

    Shotwell, H.P.; Caporossi, J.C.

    1983-02-01

    Airborne contaminant concentrations cannot always be reduced to desired levels even after the installation of feasible engineering controls. The industrial hygienist may have to recommend full-shift or partial-shift use of appropriate respirators to reduce exposures. The method described allows a recommendation to be made of the minimum period of time an exposed employee needs to use a repirator in order to reach the desired exposure level. The procedure is based on the calculation of time-weighted averages, using the upper confidence levels of air sampling data, and the respirator protection factors.

  5. Familial Hypokalemic Periodic Paralysis: A Case Report

    Directory of Open Access Journals (Sweden)

    Semih KORKUT, Hayati KANDİŞ, Harun GÜNEŞ, Esin KORKUT

    2010-11-01

    Full Text Available Familial hypokalemic periodic paralysis is an autosomal dominantly inherited congenital diseasecharacterized by intermittent attacks of muscle weakness lasting for a few hours to a few daysand occurring a few times a year or once a day. Due to the shift of potassium into muscle cells,serum potassium level is decreased during attacks and it is in the normal range between twoattacks. A 21 year old male patient seen in the emergency department due to a hypokalemicparalysis attack occurring without any obvious triggering factor was presented in this article.

  6. Periodicity, the Canon and Sport

    Directory of Open Access Journals (Sweden)

    Thomas F. Scanlon

    2015-10-01

    Full Text Available The topic according to this title is admittedly a broad one, embracing two very general concepts of time and of the cultural valuation of artistic products. Both phenomena are, in the present view, largely constructed by their contemporary cultures, and given authority to a great extent from the prestige of the past. The antiquity of tradition brings with it a certain cachet. Even though there may be peripheral debates in any given society which question the specifics of periodization or canonicity, individuals generally accept the consensus designation of a sequence of historical periods and they accept a list of highly valued artistic works as canonical or authoritative. We will first examine some of the processes of periodization and of canon-formation, after which we will discuss some specific examples of how these processes have worked in the sport of two ancient cultures, namely Greece and Mesoamerica.

  7. Inflation from periodic extra dimensions

    CERN Document Server

    Higaki, Tetsutaro

    2016-01-01

    We discuss a realization of a small field inflation based on string inspired supergravities. In theories accompanying extra dimensions, compactification of them with small radii is required for realistic situations. Since the extra dimension can have a periodicity, there will appear (quasi-)periodic functions under transformations of moduli of the extra dimensions in low energy scales. Such a periodic property can lead to a UV completion of so-called multi-natural inflation model where inflaton potential consists of a sum of multiple sinusoidal functions with a decay constant smaller than the Planck scale. As an illustration, we construct a SUSY breaking model, and then show that such an inflaton potential can be generated by a sum of world sheet instantons in intersecting brane models on extra dimensions containing $T^2/{\\mathbb Z}_2$ orbifold. We show also predictions of cosmic observables by numerical analyzes.

  8. Periodicity and repeatability in data

    Science.gov (United States)

    Southwood, D.

    Using magnetic data from the first two years in Saturn orbit, the basic periodicity of apparent is examined with the aim of elucidating the `cam' shaft model of Espinosa et al. (2003) identifying the nature of the `cam' and giving a definitive period for its rotation. An initial hypothesis, supported by the spectral analysis of analysis of the first 8 months in orbit Gianpieri et al. (2006), is made that the source of the period is linked to something inside the planet and therefore that the source inertia means that the period effectively does not change over the 2 years. Moreover one expects that the source phase is fixed. Using this approach, not only can the period identified by spectral analysis (647.1 + 0.6 min.) be verified but also by phase analysis between successive passes over the 2 years the period can be refined to 647.6 + 0.1 min. The signal itself is remarkably reproducible from pass to pass. It appears in all three components of the field and its polarisation is unambiguously not attributable to direct detection of an internal field. Not only does the signal not decay rapidly with distance from the planet, but although it has the m=1 symmetry of a tilted dipole, the field lines diverge from the planet indicating an exterior source. This feature led to the `cam' model. The polarisation and comparisons of passes with different latitude profiles show a surprising north-south symmetry in the azimuthal field. The absence of asymmetry with respect to the magnetic equator rules out a direct magnetospheric-ionospheric interaction source. Accordingly, it is proposed that the basic `cam' effect is generated by a single hemisphere anomaly which creates hemisphere to hemisphere field aligned currents. The existence of Saturn phase related anomaly appears to produce a basic asymmetry in the inner magnetosphere that sets the phase of both an inflowing and outflowing sector in a rotating circulation system.

  9. Periodic Hamiltonian hierarchies and non-uniqueness of superpotentials

    Indian Academy of Sciences (India)

    PARTHA MANDAL; ABHIJIT BANERJEE

    2017-01-01

    In this article, a family of periodic quantum Hamiltonians, that is subject to a closure condition is considered. In the context of the factorization method, we address the question of non-uniqueness of the governing superpotentials and study an alternative factorization to generate new hierarchies of potentials.

  10. Hydrogen purification by periodic adsorption

    Energy Technology Data Exchange (ETDEWEB)

    Barg, Christian; Secchi, Argimiro R.; Trierweiler, Jorge O. [Rio Grande do Sul Univ., Porto Alegre, RS (Brazil). Dept. de Engenharia Quimica]. E-mail: cbarg@enq.ufrgs.br; arge@enq.ufrgs.br; jorge@enq.ufrgs.br

    2000-07-01

    The periodic adsorption processes have been widely used for industrial applications, mainly because it spends less energy than the usual gas separation processes, like the cryogenic distillation. The largest commercial application of periodic adsorption processes is the pressure swing adsorption (PSA) applied to hydrogen purification. Although its wide use in the chemical and petrochemical industry, there are no reports in the open literature about complete modeling studies of a complex commercial unit, with multiple adsorbents and multiple beds and several feed components. This study has as objective the modeling, optimization and dynamical analysis of an industrial PSA unit for hydrogen purification. (author)

  11. Sigmoid Volvulus Complicating Postpartum Period

    Science.gov (United States)

    Blake, Erin; Gonzalez, Eduardo; Pieracci, Frederic

    2017-01-01

    Background. Sigmoid volvulus is a rare complication of pregnancy and the puerperium. Case. A 19-year-old patient, gravida 1 para 0 at 41 0/7 weeks of gestation, admitted for late-term induction of labor underwent an uncomplicated primary low transverse cesarean delivery for arrest of descent. Her postoperative period was complicated by sudden onset of abdominal pain and the ultimate diagnosis of sigmoid volvulus. Conclusion. Prompt surgical evaluation of an acute abdomen in the postpartum period is essential; delayed diagnosis and treatment can lead to significant maternal morbidity and mortality.

  12. Sigmoid Volvulus Complicating Postpartum Period

    Directory of Open Access Journals (Sweden)

    Kelsey E. Ward

    2017-01-01

    Full Text Available Background. Sigmoid volvulus is a rare complication of pregnancy and the puerperium. Case. A 19-year-old patient, gravida 1 para 0 at 41 0/7 weeks of gestation, admitted for late-term induction of labor underwent an uncomplicated primary low transverse cesarean delivery for arrest of descent. Her postoperative period was complicated by sudden onset of abdominal pain and the ultimate diagnosis of sigmoid volvulus. Conclusion. Prompt surgical evaluation of an acute abdomen in the postpartum period is essential; delayed diagnosis and treatment can lead to significant maternal morbidity and mortality.

  13. Prevalência de incontinência urinária autorreferida no pós-parto e fatores relacionados Prevalencia de incontinencia urinaria autorreferida en el postparto y factores relacionados Prevalence and related factors of self-reported urinary incontinence in the postpartum period

    Directory of Open Access Journals (Sweden)

    Daniela Biguetti Martins Lopes

    2012-01-01

    Full Text Available OBJETIVOS: Verificar a prevalência de incontinência urinária (IU autorreferida por mulheres no pós-parto e identificar os fatores relacionados. MÉTODOS: Estudo epidemiológico transversal, realizado no período de janeiro a agosto de 2009. Foram entrevistadas 288 mulheres com 30 dias a 6 meses de pós-parto. Os dados foram analisados estatisticamente. RESULTADOS: Observou-se prevalência de 24,6% de IU autorreferida no pós-parto. A idade média das mulheres foi de 26 anos, apenas a cor da pele apresentou diferença estatística significante, com maior representatividade em mulheres brancas. Dentre as 71 entrevistadas que referiram IU no pós-parto, a maioria era primípara e submeteu-se ao parto normal. CONCLUSÃO: A ocorrência de IU autorreferida no pós-parto associa-se à cor da pele com predominância em primíparas em comparação às não primíparas. Identificar os fatores relacionados à IU em mulheres no pós-parto e sua prevalência contribui no planejamento de atenção de enfermagem obstétrica à mulher que vivencia o período reprodutivo.OBJETIVOS: Verificar la prevalencia de incontinencia urinaria (IU autorreferida por mujeres en el postparto e identificar los factores relacionados. MÉTODOS: Estudio epidemiológico transversal, realizado en el período de enero a agosto del 2009. Fueron entrevistadas 288 mujeres con 30 días a 6 meses de postparto. Los datos se analizaron estadísticamente. RESULTADOS: Se observó prevalencia de 24,6% de IU autorreferida en el postparto. La edad promedio de las mujeres fue de 26 años, apenas el color de la piel presentó diferencia estadística significativa, con mayor representatividad en mujeres blancas. De las 71 entrevistadas que refirieron IU en el postparto, la mayoría era primípara y se sometió al parto normal. CONCLUSIÓN: La ocurrencia de IU autorreferida en el postparto se asocia al color de la piel con predominio en primíparas en comparación a las no primíparas. La

  14. PERIODIC COMPLEMENTARY BINARY SEQUENCE PAIRS

    Institute of Scientific and Technical Information of China (English)

    XuChengqian; ZhaoXiaoqun

    2002-01-01

    A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP)is proposed .A new class of block design-Difference Family Pair (DFP)is also proposed .The relationship between PCSP and DFP,the properties and exising conditions of PCSP and the recursive constructions for PCSP are given.

  15. PERIODIC COMPLEMENTARY BINARY SEQUENCE PAIRS

    Institute of Scientific and Technical Information of China (English)

    Xu Chengqian; Zhao Xiaoqun

    2002-01-01

    A new set of binary sequences-Periodic Complementary Binary Sequence Pair (PCSP) is proposed. A new class of block design-Difference Family Pair (DFP) is also proposed.The relationship between PCSP and DFP, the properties and existing conditions of PCSP and the recursive constructions for PCSP are given.

  16. Glass Waveguides for Periodic Poling

    DEFF Research Database (Denmark)

    Fage-Pedersen, Jacob; Jacobsen, Rune Shim; Kristensen, Martin

    2005-01-01

    Planar silica-based waveguide devices have been developed for second-harmonic generation by poling with periodic electrodes. We show that detrimental charge transport can occur along interfaces, but with proper choice of fabrication, high-quality devices are obtained....

  17. Pairs of dual periodic frames

    DEFF Research Database (Denmark)

    Christensen, Ole; Goh, Say Song

    2012-01-01

    is needed. The purpose of the present paper is to provide constructions of dual pairs of frames in the setting of the Hilbert space of periodic functions L2(0,2π). The frames constructed are given explicitly as trigonometric polynomials, which allows for an efficient calculation of the coefficients...

  18. Quasi-Periodic Spatiotemporal Filtering

    NARCIS (Netherlands)

    Burghouts, G.J.; Geusebroek, J.M.

    2006-01-01

    This paper presents the online estimation of temporal frequency to simultaneously detect and identify the quasi-periodic motion of an object. We introduce color to increase discriminative power of a reoccurring object and to provide robustness to appearance changes due to illumination changes. Spati

  19. Coupling light to periodic nanostructures

    NARCIS (Netherlands)

    Driessen, Eduard Frans Clemens

    2009-01-01

    This thesis describes coupling of light to periodic structures. A material is patterned with a regular pattern on a length scale comparable to the wavelength of light. With these structures, light can be manipulated very precisely. The structures find applications in semiconductor lasers, light emit

  20. Periodic progress report, 6 months

    DEFF Research Database (Denmark)

    Juhl, Thomas Winther; Nielsen, Jakob Skov

    This is the first progress report of the BriteEuram project named "High Power Laser Cutting for Heavy Industry" ("Powercut"). The report contains a summary of the objectives of the first period, an overview of the technical progress, a comparison between the planed and the accomplished work...

  1. Periodic solutions and slow manifolds

    NARCIS (Netherlands)

    Verhulst, F.

    2006-01-01

    After reviewing a number of results from geometric singular perturbation theory, we give an example of a theorem for periodic solutions in a slow manifold. This is illustrated by examples involving the van der Pol-equation and a modified logistic equation. Regarding nonhyperbolic transitions we disc

  2. Periodic progress report, 6 months

    DEFF Research Database (Denmark)

    Juhl, Thomas Winther; Nielsen, Jakob Skov

    This is the first progress report of the BriteEuram project named "High Power Laser Cutting for Heavy Industry" ("Powercut"). The report contains a summary of the objectives of the first period, an overview of the technical progress, a comparison between the planed and the accomplished work...

  3. Quantifying Periodicity in Omics Data

    Directory of Open Access Journals (Sweden)

    Cornelia eAmariei

    2014-08-01

    Full Text Available Oscillations play a significant role in biological systems, with many examples in the fast, ultradian, circadian, circalunar and yearly time domains. However, determining periodicity in such data can be problematic. There are a number of computational methods to identify the periodic components in large datasets, such as signal-to-noise based Fourier decomposition, Fisher's g-test and autocorrelation. However, the available methods assume a sinusoidal model and do not attempt to quantify the waveform shape and the presence of multiple periodicities, which provide vital clues in determining the underlying dynamics. Here, we developed a Fourier based measure that generates a de-noised waveform from multiple significant frequencies. This waveform is then correlated with the raw data from the respiratory oscillation found in yeast, to provide oscillation statistics including waveform metrics and multi-periods. The method is compared and contrasted to commonly used statistics. Moreover we show the utility of the program in the analysis of noisy datasets and other high-throughput analyses, such as metabolomics and flow cytometry, respectively.

  4. Glass Waveguides for Periodic Poling

    DEFF Research Database (Denmark)

    Fage-Pedersen, Jacob; Jacobsen, Rune Shim; Kristensen, Martin

    2005-01-01

    Planar silica-based waveguide devices have been developed for second-harmonic generation by poling with periodic electrodes. We show that detrimental charge transport can occur along interfaces, but with proper choice of fabrication, high-quality devices are obtained....

  5. Shanghai's Fashion During Republic Period

    Institute of Scientific and Technical Information of China (English)

    卞向阳

    2004-01-01

    The goal of this research is to describe and analyze Shanghai's fashion during Republic Period. Shanghai's fashion during Republic Period plays a special role in fashion history of China and Shanghai history. In the paper, three aspects including the fashion centre of China as well as Far East, men's fashion and women's fashion in Shanghai are discussed. The style, textiles, color, decoration and combination of clothing are described. Many costumes from the Clothing Museum at Donghua University and private collections as well as some historical writings, photographs and publications are elucidated and corroborated to give a more detailed description about Shanghai's fashion during that period.Here are some tentative conclusions. Firstly, Shanghai had always been the fashion center in China even Far East during Republic Period. Modeng was the main reflection of Shanghai fashion. Secondly, the traditional clothing exerted less influence and was less widely used, some kinds and combinations were out of fashion gradually. The fashion was described to be highly stylized, exquisite and concise. Thirdly, the influence of Western Style was further greater. The fashion in Shanghai was almost synchronous with fashion of Paris. Some western clothing was directly used in daily life and the elements of Western Style had an increasingly wide utilization. Fourthly, the New Chinese Style whose representatives were Qipao and Zhongshan Zhuang appeared and popularized in Shanghai. The fashion of Qipao changed frequently. Finally, the fashion in Shanghai called Shanghai Style could be summarized fashionable, exquisite, rapidly changeable, which is harmonious of both ancient and modern, Chinese and foreign.

  6. Soliton Management in Periodic Systems

    CERN Document Server

    Malomed, Boris A

    2006-01-01

    During the past ten years, there has been intensive development in theoretical and experimental research of solitons in periodic media. This book provides a unique and informative account of the state-of-the-art in the field. The volume opens with a review of the existence of robust solitary pulses in systems built as a periodic concatenation of very different elements. Among the most famous examples of this type of systems are the dispersion management in fiber-optic telecommunication links, and (more recently) photonic crystals. A number of other systems belonging to the same broad class of spatially periodic strongly inhomogeneous media (such as the split-step and tandem models) have recently been identified in nonlinear optics, and transmission of solitary pulses in them was investigated in detail. Similar soliton dynamics occurs in temporal-domain counterparts of such systems, where they are subject to strong time-periodic modulation (for instance, the Feshbach-resonance management in Bose-Einstein conde...

  7. System Optimization by Periodic Control.

    Science.gov (United States)

    1979-09-30

    extended re- sults are now contained in a single report [3] which will appear as a regular paper in the December, 1979 issue of the IEEE Transactions on Automatic Control . The...Test Revisited, " to appear in the IEEE Transactions on Automatic Control . 4. D. J. Lyons, "Improved Aircraft Cruise by Periodic Control," Ph. D

  8. 76 FR 80312 - Periodic Reporting

    Science.gov (United States)

    2011-12-23

    ... of the Business Reply Mail cost model in periodic reporting of service performance measurement... initiate a rulemaking proceeding to address the current methodology used to develop the avoided cost.... SUMMARY: The Commission is establishing a docket to consider new measurement of Flats Sequencing...

  9. Hyperkalemic periodic paralysis associated with multiple sleep onset REM periods.

    Science.gov (United States)

    Iranzo, A; Santamaria, J

    1999-12-15

    A 24-year-old man with sporadic hyperkalemic periodic paralysis (HPP) presented with moderate excessive daytime sleepiness and transitory episodes of weakness which occurred during and after sleep. Multiple sleep latency test (MSLT) demonstrated the presence of five sleep onset REM periods (SOREMPs) and a sleep latency of five minutes. Treatment with a diuretic which decreases serum potassium resolved all the clinical symtomps and a new MSLT showed the absence of SOREMPs and a sleep latency of 13.5 minutes. To our knowledge, the patient herein reported is the first case that associates sleep abnormalities and multiple SOREMPs with HPP. Furthermore, the present case suggests that SOREMPs may be explained by an increased extracellular potassium conductance related to HPP.

  10. Factores que influyen sobre los resultados del tratamiento quirúrgico en aneurismas de la arteria cerebral media (Hospital «Hermanos Ameijeiras», 1983 a 2004 Factors affecting the results of the surgical treatment of aneurysms of the middle cerebral artery (“Hermanos Ameijeiras” hospital in the period 1983 to 2004

    Directory of Open Access Journals (Sweden)

    Justo L González González

    2007-09-01

    Full Text Available Los aneurismas de la arteria cerebral media son los causantes de la quinta parte de las hemorragias subaracnoideas aneurismáticas, y este vaso es el segundo sitio más frecuente de formación de aneurismas intracraneales. En este artículo se analizaron los resultados quirúrgicos en 53 pacientes con aneurismas de esta arteria. Los pacientes fueron operados entre 1984 y 2004 en el Hospital «Hermanos Ameijeiras» y sus edades estuvieron en rango de 20 a 60 años. Egresó con buenos resultados el 69,8 % de los pacientes, mientras que el 7,6 % lo hizo con secuelas leves y el 22,6 %, con secuelas graves. No hubo muertes en la serie. Los resultados mostraron una fuerte dependencia del estado preoperatorio evaluado según la escala de la Federación Mundial de Sociedades Neuroquirúrgicas: 82,7 % de pacientes con buenos resultados habían ingresado con grado I y 75 % de los pacientes con secuelas graves ingresaron con grado III b. Las complicaciones también incidieron significativamente sobre los resultados al egreso y, entre ellas, el infarto cerebral fue la de peor pronóstico (p = 0,0008Aneurysms of the middle cerebral artery are responsible for 20 % of aneurysmal subarachnoid hemorrhages and at the same time, this vessel is the second most common site of intracranial aneurysm formation. This article analyzed the surgical outcomes in 53 patients suffering from aneurysms in this artery. The patients aged 20 to 60 years-old were operated on at “Hermanos Ameijeiras” hospital in the period from 1984 to 2004. Good results were achieved in 69,8 % of patients whereas 7,6 % and 22,6 % of them had slight and serious sequelae respectively on discharge. No death was found in this series. It was observed that results were heavily dependent on the pre-operative state of the patient assessed according to the World Federation of Neurosurgical Societies scale: 82,7 % of those with good surgical results had been admitted at grade I of the scale but 75 % with

  11. 7 CFR 1160.113 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Fiscal period. 1160.113 Section 1160.113 Agriculture... Definitions § 1160.113 Fiscal period. Fiscal period means the initial period of up to 30 months that this subpart is effective. Thereafter, the fiscal period shall be such annual period as the Board may...

  12. Geopulsation, Volcanism and Astronomical Periods

    Institute of Scientific and Technical Information of China (English)

    Yang Xuexiang; Chen Dianyou; Yang Xiaoying; Yang Shuchen

    2000-01-01

    Volcanism is mainly controlled by the intermittent release of energy in the earth. As far as the differential rotation of the earth's inner core is concerned, the Galactic Year may change the gravitational constant G, the solar radiative quantity and the moving speed of the solar system and affect the exchange of angular momentum between core and mantle as well as the energy exchange between crust and mantle. As a result, this leads to eruptions of superplumes and magma, and controls the energy flow from core - mantle boundary (CMB) to crust. When the earth' s speed decreases, it will release a huge amount of energy. They are the reason of the correspondence of the volcanic cycles one by one with the astronomical periods one by one. According to the astronomical periods, volcanic eruptions may possibly be predicted in the future.

  13. Fibromyalgia in hyperkalemic periodic paralysis.

    Science.gov (United States)

    Götze, F R; Thid, S; Kyllerman, M

    1998-01-01

    A 43-year-old woman presented at the age of 38 with joint pains and muscle stiffness. Tender points were found fulfilling ACR criteria (1) for fibromyalgia. She had well developed muscles and decreasing muscle power since the age of 35. Muscle pains increased after exercise. Her 10-year-old son had similar symptoms and one paralytic attack. Muscle pain and fatigue increasing with age were found by history in three close relatives. Forearm cold water test produced myotonia in both mother and son. Electromyography was normal and muscle biopsy showed minor unspecific changes. Biochemical investigation of muscle mitochondrial function was normal. Peroral potassium load test produced complete muscle paralysis at a potassium serum level of 5.0 mmol/l. Autosomal dominant hyperkalemic periodic paralysis was diagnosed. Frequent carbohydrate enriched meals, peroral bendroflumethiazide and restriction to submaximal exercise improved muscle and joint pain. Salbutamol peroral spray relieved the periodic weakness.

  14. Exploration of Periodically Varying Graphs

    CERN Document Server

    Flocchini, Paola; Santoro, Nicola

    2009-01-01

    We study the computability and complexity of the exploration problem in a class of highly dynamic graphs: periodically varying (PV) graphs, where the edges exist only at some (unknown) times defined by the periodic movements of carriers. These graphs naturally model highly dynamic infrastructure-less networks such as public transports with fixed timetables, low earth orbiting (LEO) satellite systems, security guards' tours, etc. We establish necessary conditions for the problem to be solved. We also derive lower bounds on the amount of time required in general, as well as for the PV graphs defined by restricted classes of carriers movements: simple routes, and circular routes. We then prove that the limitations on computability and complexity we have established are indeed tight. In fact we prove that all necessary conditions are also sufficient and all lower bounds on costs are tight. We do so constructively presenting two worst case optimal solution algorithms, one for anonymous systems, and one for those w...

  15. Social Research On Renaissance Period

    Institute of Scientific and Technical Information of China (English)

    张蕾蕾

    2009-01-01

    The historical period known as the Renaissance spans the fifteenth and siXteenth centuries. ‘Renaissance'means‘re-birth'in French and during this time Europe left behind the mindset of the Midge Ages and created the beginnings of the modern world.This thesis mainly rotates on the background,the main features and significance of Renaissance,especially focuses on the discovery of man and the humanism and the detailed unfolding of the society on several aspect in Renaissance.

  16. Periodic Convergences: Dance and Computers

    OpenAIRE

    deLahunta, Scott

    2002-01-01

    Published in German and English, this chapter is one of deLahunta's major outputs to emerge from a group of related research outputs, concerning "dance and technology". In it he explores the history of the convergence between dance and computers from the 1960s to the 1990s, arguing that this convergence has been periodic, involving particular artists at particular times, rather than producing a genre of work (as others have speculated). As the mainstream of contemporary dance evolved alongsid...

  17. Periodic Structures in Optical Fibres.

    Science.gov (United States)

    Hand, Duncan Paul

    1990-01-01

    Available from UMI in association with The British Library. The work presented in this thesis concerns techniques for the formation of periodic structures in optical fibres. Two different methods of producing such structures are studied in detail. The first of these involves a breakdown mechanism (known as the 'fibre fuse') that permanently damages the core glass in a periodic manner leaving it unable to guide light. The dynamics of this mechanism are studied, with a view to controlling it for the production of interactive grating structures. It is determined that, due to a sharp rise in fibre absorption with temperature, a thermal shock -wave, with a typical thermal gradient of several hundred degrees Kelvin per micron, forms and travels along the fibre, heating the core glass to such an extent that damage occurs. The periodicity of the resultant damage arises from thermal focusing and defocusing of light in the region of this shock-wave. The second method makes use of the photorefractivity observed in certain germanosilicate fibres on exposure to moderate intensity blue light of wavelength ~480nm or UV light ~240nm. A single-mode fibre transmission filter is demonstrated for the first time, produced by exposing a fibre Sagnac loop mirror to 488nm holographic fringes. Average index changes are shown to occur if such fibres are exposed to spatially uniform blue or UV light, indicating that grating formation is by a different mechanism to the local charge separation which occurs in photorefractive crystals. The various characteristics of these average index changes are measured and analysed, with the conclusion that they result from defect centre formation, driven by two photon absorption with blue light, or single photon absorption with UV light. Associated birefringence changes are also measured and are exploited in a hi-bi fibre to periodically perturb the birefringence axes, producing a narrow-line transmission filter.

  18. Regular and Periodic Tachyon Kinks

    OpenAIRE

    Bazeia, D.; Menezes, R.; Ramos, J. G.

    2004-01-01

    We search for regular tachyon kinks in an extended model, which includes the tachyon action recently proposed to describe the tachyon field. The extended model that we propose adds a new contribution to the tachyon action, and seems to enrich the present scenario for the tachyon field. We have found stable tachyon kinks of regular profile, which may appropriately lead to the singular kink found by Sen sometime ago. Also, under specific conditions we may find periodic array of kink-antikink co...

  19. Constituents of Doubly Periodic Instantons

    CERN Document Server

    Ford, C; Ford, Chris; Pawlowski, Jan M.

    2002-01-01

    Using the Nahm transform we investigate doubly periodic charge one SU(2) instantons with radial symmetry. Two special points where the Nahm zero modes have softer singularities are identified as constituent locations. To support this picture, the action density is computed analytically and numerically within a two dimensional slice containing the two constituents. For particular values of the parameters the torus can be cut in half yielding two copies of a twisted charge 1/2 instanton. Such objects comprise a single constituent.

  20. Periodic paralysis: clinical evaluation in 20 patients

    Directory of Open Access Journals (Sweden)

    Célia Harumi Tengan

    1994-12-01

    Full Text Available Twenty patients with periodic paralysis were evaluated and the aspects studied included epidemiological data, clinical manifestations, ancillary tests, treatment and evolution. Sixteen patients had the hypokalemic form (5 familiar, 5 sporadic, 5 thyrotoxic and 1 secondary. No patient with the normokalemic form was detected. Predominance of men was found (14 patients, especially in the cases with hyperthyroidism (5 patients. No thyrotoxic patient was of oriental origin. Only 4 patients had the hyperkalemic form (3 familiar, 1 sporadic. Attacks of paralysis began during the first decade in the hyperkalemic form and up to the third decade in the hypokalemic. In both forms the attacks occurred preferentially in the morning with rest after exercise being the most important precipitating factor. Seventy five percent of the hyperkalemic patients referred brief attacks (<12 hours. Longer attacks were referred by 43% of the hypokalemic patients. The majority of the attacks manifested with a generalized weakness mainly in legs, and its frequency was variable. Creatinokinase was evaluated in 10 patients and 8 of them had levels that varied from 1,1 to 5 times normal. Electromyography was done in 6 patients and myotonic phenomenon was the only abnormality detected in 2 patients. Carbonic anhydrase inhibitors, especially acetazolamide, were used for prophylactic treatment in 9 pacients with good results in all. Although periodic paralysis may be considered a benign disease we found respiratory distress in 5 patients, permanent myopathy in 1, electrocardiographic abnormalities during crises in 4; death during paralysis occurred in 2. Therefore correct diagnosis and immediate treatment are crucial. This study shows that hyperthyroidism is an important cause of periodic paralysis in our country, even in non oriental patients. Hence endocrine investigation is mandatory since this kind of periodic paralysis will only be abated after return to the euthyroid state.

  1. Mining approximate periodic pattern in hydrological time series

    Science.gov (United States)

    Zhu, Y. L.; Li, S. J.; Bao, N. N.; Wan, D. S.

    2012-04-01

    There is a lot of information about the hidden laws of nature evolution and the influences of human beings activities on the earth surface in long sequence of hydrological time series. Data mining technology can help find those hidden laws, such as flood frequency and abrupt change, which is useful for the decision support of hydrological prediction and flood control scheduling. The periodic nature of hydrological time series is important for trend forecasting of drought and flood and hydraulic engineering planning. In Hydrology, the full period analysis of hydrological time series has attracted a lot of attention, such as the discrete periodogram, simple partial wave method, Fourier analysis method, and maximum entropy spectral analysis method and wavelet analysis. In fact, the hydrological process is influenced both by deterministic factors and stochastic ones. For example, the tidal level is also affected by moon circling the Earth, in addition to the Earth revolution and its rotation. Hence, there is some kind of approximate period hidden in the hydrological time series, sometimes which is also called the cryptic period. Recently, partial period mining originated from the data mining domain can be a remedy for the traditional period analysis methods in hydrology, which has a loose request of the data integrity and continuity. They can find some partial period in the time series. This paper is focused on the partial period mining in the hydrological time series. Based on asynchronous periodic pattern and partial period mining with suffix tree, this paper proposes to mine multi-event asynchronous periodic pattern based on modified suffix tree representation and traversal, and invent a dynamic candidate period intervals adjusting method, which can avoids period omissions or waste of time and space. The experimental results on synthetic data and real water level data of the Yangtze River at Nanjing station indicate that this algorithm can discover hydrological

  2. Evidence-based provisional clinical classification criteria for autoinflammatory periodic fevers

    NARCIS (Netherlands)

    Federici, Silvia; Sormani, Maria Pia; Ozen, Seza; Lachmann, Helen J; Amaryan, Gayane; Woo, Patricia; Koné-Paut, Isabelle; Dewarrat, Natacha; Cantarini, Luca; Insalaco, Antonella; Uziel, Yosef; Rigante, Donato; Quartier, Pierre; Demirkaya, Erkan; Herlin, Troels; Meini, Antonella; Fabio, Giovanna; Kallinich, Tilmann; Martino, Silvana; Butbul, Aviel Yonatan; Olivieri, Alma; Kuemmerle-Deschner, Jasmin; Neven, Benedicte; Simon, Anna; Ozdogan, Huri; Touitou, Isabelle; Frenkel, Joost; Hofer, Michael; Martini, Alberto; Ruperto, Nicolino; Gattorno, Marco

    2015-01-01

    The objective of this work was to develop and validate a set of clinical criteria for the classification of patients affected by periodic fevers. Patients with inherited periodic fevers (familial Mediterranean fever (FMF); mevalonate kinase deficiency (MKD); tumour necrosis factor

  3. EXISTENCE AND GLOBAL ATTRACTIVITY OF ALMOST PERIODIC SOLUTION TO A DELAYED DIFFERENTIAL EQUATION

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    A new fixed point theorem is presented and sufficient conditions are obtained for the existence, uniqueness and global attractivity of a positive almost periodic solution to a delayed differential equation with almost periodic factors.

  4. Influencing factors of high intraocular pressure during stable period after implantable collamer lens%有晶体眼后房型人工晶体植入术后稳定期高眼压发生的相关因素分析

    Institute of Scientific and Technical Information of China (English)

    胡春明; 谢汉平; 汪辉; 罗启惠

    2012-01-01

    Objective To investigate influencing factors of high intraocular pressure (IOP) during stable period (1 to 3 months) after implantable collamer lens (ICL) and therapeutic efficacy. Methods Clinical data of 79 high myopia patients ( 155 eyes) who received ICL from January to December in 2011 were analyzed retrospectively. They were 36 males and 43 females, with an age ranging from 18 to 46 (mean 23. 84 ?6. 54) , and were followed up within 6 months post-operatively. IOP, uncorrected visual acuity, best corrected visual acuity, refractive diopter, slit lamp examination, gonioscopy, coneal endocellion, central anterior chamber depth (ACD) , lens thickness, axial length, vault and trabecular-iris angle (TIA) were observed and analyzed. Results Eight patients (16 eyes) experienced high IOP during stable period post-operatively with an incidence of 10. 32% (16/155). Non-high IOP after ICL was found in 71 patients ( 139 eyes). Fourteen eyes (87.5%) out of 16 eyes were treated with drops and good outcomes were obtained, but the left 2 eyes (12. 5% ) had to turn to surgery which were uncontrollable with drops. Pre- and post-operative ACD, post-operative vault and TIA were closely related to high IOP during stable period after ICL( P < 0. 05 , P < 0. 01). Post-operative TIA was an independent influencing factor for high IOP after ICL. IOP and best corrected visual acuity (BCVA) were 26.13 +3.56 mmHg and 0. 69 +0. 20 in stable period, 19.98 +2.51 mmHg and 0.80 + 0. 19 in 1 week after treatment, and 17. 58 +2. 30 mmHg and 0. 84 +0. 19 at the end of follow-up. There were significant difference between those of the stable period with those of later 2 time points (P < 0. 05 , P < 0. 01). Conclusion High IOP during stable period after ICL may be related to not matching good enough between ICL and eye ball, which induces chronic inflammation for long time.%目的 探讨有晶体眼后房型人工晶体(implantable collamer lens,ICL)植入术后稳定期发生高眼压的相关影

  5. 小儿全身麻醉苏醒期呼吸道并发症发生的影响因素分析%Risk Factors Analysis of the Occurrence of Airway Adverse Events in Pediatric General Anesthesia Awakening Period

    Institute of Scientific and Technical Information of China (English)

    杨琰

    2014-01-01

    目的:探讨小儿全身麻醉苏醒期呼吸道并发症发生的影响因素。方法选择2011年3月至2014年3月收住复旦大学附属中山医院、择期行脐以下手术(时程>30 min)或行骨手术或泌尿手术的患儿(年龄1~8岁)共100例,美国麻醉师协会分级评定为Ⅰ~Ⅱ级,按患儿实际接受手术的先后顺序、根据随机数字表法给予患儿全麻术后不同的通气装置,分别是一定麻醉深度下拔除气管导管(ETT-A)组、一定麻醉深度下移除喉罩(LMA-A组)、清醒下拔除气管导管(ETT-W)组和清醒下拔除喉罩(LMA-W)组。观察和记录成功插管的次数,患儿苏醒时间及苏醒期呼吸道并发症的情况(有无呼吸道分泌物增多、咳嗽、喉痉挛等),并进行多因素 Logistic回归分析。结果 ETT-W组的苏醒时间较 ETT-A组、LMA-A组、LMA-W组显著减少,差异有统计学意义(P <0.05);ETT-W 组苏醒期呼吸道并发症发生率高于ETT-A组、LMA-A组和LMA-W组(P<0.05)。多因素Logistic回归分析结果显示,通气装置的选择为危害性因素,年龄及拔管(喉罩移除)时麻醉状态为保护性因素。结论选择气管导管更易引发小儿全麻苏醒期呼吸道并发症,需重视和加强手术前后的监护,积极预防和减少并发症的发生,以提高小儿围术期麻醉的安全性。%Objective To investigate the risk factors of the occurrence of airway adverse events in pedi-atric general anesthesia awakening period.Methods During Mar.2011-Mar.2014,a total of 100 children ( aged 1-8 years) , with the surgery below the umbilicus ( >30 min) or bone surgery or urological surgery, and ASA (American Society of Anesthesiologists) for Ⅰ-Ⅱ level,were included in the study,who were giv-en different anesthesia ventilation devices according to the actual surgery order and with random number table method after general anesthesia operation.They were

  6. Forgiveness in the intertestamental period

    Directory of Open Access Journals (Sweden)

    Sang-Mong Lee

    2012-02-01

    Full Text Available The article suggests answers to the following questions: what are the characteristics of God�s forgiveness in the intertestamental literature and what connection do these characteristics have with the Old Testament? Important passages in the late Second Temple period that expose the characteristics of God�s forgiveness, such as certain Qumran texts (1QH 12:35�37, 1QH 13:2 and the Damascus Document 14:18�19, the writings of Philo and Josephus, the Apocrypha and the Pseudepigrapha, are investigated for this purpose.

  7. Periodic roads and quantized wheels

    Science.gov (United States)

    de Campos Valadares, Eduardo

    2016-08-01

    We propose a simple approach to determine all possible wheels that can roll smoothly without slipping on a periodic roadbed, while maintaining the center of mass at a fixed height. We also address the inverse problem that of obtaining the roadbed profile compatible with a specific wheel and all other related "quantized wheels." The role of symmetry is highlighted, which might preclude the center of mass from remaining at a fixed height. A straightforward consequence of such geometric quantization is that the gravitational potential energy and the moment of inertia are discrete, suggesting a parallelism between macroscopic wheels and nano-systems, such as carbon nanotubes.

  8. Relation between environmental factors and nocturnal active rhythm during the pre-reproductive period of the Chinese giant salamander%中国大鲵繁殖前期夜间活动节律及其与环境因子的关系

    Institute of Scientific and Technical Information of China (English)

    于虎虎; 梁刚; 刘巧巧; 徐文刚

    2013-01-01

    During the pre-reproductive period,the nocturnal active rhythm of the Chinese giant salamander Andrias davidianus and environmental factors were investigated from July to August in 2011 at imitated-natural habitat of the Qinling Mountains using all occurrence recording methods.The results showed that Chinese giant salamander moved out at 7:30 PM,their activities reached the peak in 9:30 PM and remained to the next day 1:30 AM.After 6:30 AM,all Chinese giant salamanders returned to the den.There were significant differences in nocturnal activity between male and female,while there were no difference in nocturnal activity between the adult and the subadult.Illumination intensity and water temperature were well correlated with the nocturnal activity times.The Chinese giant salamander began to come out or to back when the illumination was 685 ~ 1 431 lx or the relative illumination was 3%.The peaks of activities occurred when the water temperature ranged from 17.1~18.4℃ (2 hours after the illumination was 0 lx).This study demonstrated that the illumination and water temperature affected the nocturnal activity rhythm of the Chinese giant salamander during the pre-reproductive period,the illumination was the key factor which controlled the activities outside of the den,and the water temperature was the main factor to determine the activity peaks.%采用全事件记录法,2011年7-8月对秦岭南坡仿生态环境下养殖的中国大鲵繁殖前期夜间活动节律及影响其出洞活动的环境因子进行了研究.结果表明:每天19:30大鲵开始出洞活动,21:30至次日凌晨1:30为出洞活动高峰期,6:30后返回洞穴;雌性和雄性成鲵的夜间活动数量存在显著差异,成体与亚成体的夜间活动数量无显著差异;在不同天气条件下,大鲵出洞活动的数量与水温、光照强度的相关性较强;当光照强度在685~1 431 lx、相对光照强度为3%时大鲵开始出洞活动或回洞

  9. Risk factors associated with death in patients who initiate treatment for tuberculosis after two different follow-up periods Fatores de risco associados com o óbito em pacientes que iniciam o tratamento para a tuberculose após dois diferentes períodos de seguimento

    Directory of Open Access Journals (Sweden)

    Maria de Fátima Pessoa Militão de Albuquerque

    2009-12-01

    Full Text Available INTRODUCTION: Mortality from tuberculosis, which should be a rare event, still affects a large portion of the population of developing countries. In this context, Recife, a city in the northeast of Brazil where this study was developed, has the highest tuberculosis mortality rates of the Brazilian capitals. OBJECTIVE: To analyze survival probability and identify risk factors for death from tuberculosis in a cohort of patients living in Recife who started treatment for tuberculosis. METHODOLOGY: A cohort of newly diagnosed TB cases was followed up from the beginning of treatment (in 2001-2003 until June 2007. Survival probability was estimated by Kaplan-Meier method; and Cox Regression analysis was used to identify risk factors. RESULTS: At the end of the follow-up period, the survival probability after beginning TB treatment was 95.9%. Older ages, positivity for HIV and late initial treatment were statistically associated with death from TB in one year follow-up. When the analysis was done considering the total period of follow-up, older ages, positivity serology for HIV, late initial treatment, weight loss, and history of previous treatment remained in the multivariate Cox regression model. CONCLUSION: A more comprehensive analysis, specifically for deaths from tuberculosis as the underlying and non-underlying cause, allowed identification of a greater number of predictive factors that would otherwise not be detected if follow-up had lasted only until the end of treatment. These results can guide feasible interventions for health services aiming to reduce case-fatality from tuberculosis.INTRODUÇÃO: A mortalidade por tuberculose, que deveria ser um evento raro, ainda acomete uma grande parcela da população dos países em desenvolvimento. Nesse contexto, Recife, situada no Nordeste do Brasil, tem uma das mais altas taxas de mortalidade das capitais brasileiras. OBJETIVO: Analisar a probabilidade de sobrevida e identificar os fatores de risco

  10. Diagnósticos de enfermagem, fatores relacionados e de risco no pós-operatório de cirurgia bariátrica Diagnósticos de enfermería, factores relacionados y de riesgo en el postoperatorio de cirugía bariátrica Nursing diagnoses, related factors and risk factors during the postoperative period following bariatric surgery

    Directory of Open Access Journals (Sweden)

    Rosa Aparecida Nogueira Moreira

    2013-02-01

    Full Text Available Objetivou-se com esta pesquisa identificar os principais diagnósticos, fatores relacionados e de risco da classe resposta cardiovascular/pulmonar, propostos pela NANDA, versão 2009-2011. Trata-se de estudo de série de caso, descritivo, realizado com vinte pacientes submetidos à cirurgia bariátrica em hospital público de Fortaleza-CE, Brasil. Duas enfermeiras especialistas em unidade de terapia intensiva coletaram os dados por meio de entrevista, exame físico e leitura do prontuário, que foram analisados a partir de estatística descritiva e mapeamento cruzado. Os diagnósticos de enfermagem identificados com frequência maior que 50% foram: débito cardíaco diminuído (75%, padrão respiratório ineficaz (65%, resposta disfuncional ao desmame ventilatório (55% e perfusão tissular periférica ineficaz (75%, dos quais 14 eram fatores relacionados e cinco, de risco. Reconhece-se a necessidade de outros estudos para melhor definir o perfil diagnóstico dessa clientela e, assim, direcionar a assistência de enfermagem para a detecção precoce de complicações.Se objetivó identificar los principales diagnósticos, factores relacionados y de riesgo del tipo respuesta cardiovascular/pulmonar, propuestos por la NANDA, versión 2009-2011.Estudio de serie de casos, descriptivo, realizado con veinte pacientes sometidos a cirugía bariátrica en hospital público de Fortaleza-CE, Brasil. Dos enfermeras especialistas en unidad de terapia intensiva recolectaron los datos mediante entrevista, examen físico y lectura de historia clínica, dichos datos fueron analizados mediante estadística descriptiva y mapeo cruzado. Los diagnósticos de enfermería identificados con frecuencia mayor al 50% fueron: gasto cardíaco disminuido (75%, patrón respiratorio ineficaz (65%, respuesta disfuncional al destete del respirador (55% y perfusión tisular periférica inefectiva (75%, de los cuales 14 constituían factores relacionados, y 5 de riesgo. Se

  11. Magnetohydrodynamic mixed convection flow in vertical concentric annuli with time periodic boundary condition: Steady periodic regime

    Indian Academy of Sciences (India)

    BASANT K JHA; BABATUNDE AINA

    2016-08-01

    This work reports an analytical solution for fully developed mixed convection flow of viscous,incompressible, electrically conducting fluid in vertical concentric annuli under the influence of a transverse magnetic field, where the outer surface of inner cylinder is heated sinusoidally and the inner surface of outercylinder is kept at a constant temperature. The analysis is carried out for fully developed parallel flow and steady-periodic regime. The governing dimensionless momentum and energy equations are separated into steadyand periodic parts and solved analytically. Closed form solutions are expressed in terms of modified Bessel function of first and second kind. The influence of each governing parameters such as magnetic field parameter,Prandtl number and the dimensionless frequency of heating on flow formation and thermal behaviour are discussed with the aid of graphs. During the course of investigation, it is found that the oscillation amplitude of the friction factor is maximized at a resonance frequency near the surface of the concentric annuli where there is periodic heating. Furthermore, increasing transverse magnetic field decreases the oscillation amplitude of the friction factor.

  12. 7 CFR 955.113 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 955.113 Section 955.113 Agriculture... and Regulations § 955.113 Fiscal period. Pursuant to § 955.13, fiscal period shall mean the period beginning January 1 and ending December 31 of each year, except that the fiscal period that began...

  13. 7 CFR 929.106 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 929.106 Section 929.106 Agriculture... LONG ISLAND IN THE STATE OF NEW YORK Rules and Regulations § 929.106 Fiscal period. The fiscal period... include the period of August 1, through August 31, 1968. Thereafter, the fiscal period will begin...

  14. 44 CFR 206.112 - Registration period.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Registration period. 206.112... Households § 206.112 Registration period. (a) Initial period. The standard FEMA registration period is 60...) Extension of the registration period. The regional administrator or his/her designee may extend the...

  15. 7 CFR 920.7 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 920.7 Section 920.7 Agriculture... Definitions § 920.7 Fiscal period. Fiscal period is synonymous with fiscal year and means a 12-month period... period as the committee, with the approval of the Secretary, may prescribe. ...

  16. 7 CFR 955.13 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 955.13 Section 955.13 Agriculture... Definitions § 955.13 Fiscal period. Fiscal period means the 12-month period beginning on September 16 and ending on September 15 of the next year or such other period that may be recommended by the committee and...

  17. 7 CFR 930.7 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 930.7 Section 930.7 Agriculture... Definitions § 930.7 Fiscal period. Fiscal period is synonymous with fiscal year and means the 12-month period beginning on July 1 of any year and ending on June 30 of the following year, or such other period as the...

  18. A binary sequence of period 60 with better autocorrelation properties than the Barker sequence of period 13

    Science.gov (United States)

    Watkins, J.; Loftsson, J.; Tyler, S.

    1985-01-01

    A binary sequence of period 60 has been discovered which in some respects has better autocorrelation properties than the Barker sequence of period 13. When both sequences are processed using appropriate sidelobe-eliminating mismatched filters, the Barker sequence's main lobe is reduced by a factor of 1.040 or 0.17 dB, while the new sequence's main lobe is reduced by a factor of only 1.035 or 0.15 dB. This sequence is the first counterexample known to the authors of the hypothesis that the autocorrelation properties of all sequences of periods greater than 13 are inferior to those of the Barker period-13 sequences. Sequences of this type are very useful in radar and deep space communications, especially in situations where there is an adverse signal to noise ratio.

  19. 肝移植术后患者早期呼吸机脱机延迟的术前及术中危险因素%Pre-and intra-operative risk factors associated with delayed weaning from ventilator during early postoperative period in patients undergoing liver transplantation

    Institute of Scientific and Technical Information of China (English)

    张欢; 杨拔贤; 王天龙

    2010-01-01

    Objective To evaluate the pre- and intra-operative risk factors associated with delayed weaning from ventilator during the early postoperative period in patients undergoing liver transplantation.Methods Two hundred and twelve patients (152 male, 60 female) aged 22-69 yr undergoing liver transplantation from Sept 2004to Aug 2006 were enrolled in this study and were divided into 2 groups according to the time when the patients were weaned from ventilator: normal weaning group (Group A, the patients weaned from ventilator within 24 h after operation) and delayed weaning group (Group B, the patients weaned from ventilator more than 24 h after operation). Routine anesthesia wes performed. Blood and blood products were transfused according to the guidelines for blood transfusion to maintain the mean arterial pressure (MAP)≥60 mm Hg during operation. Sixteen preoperative variables (age>64 yr, gender, BMI ≥ 30kg/m2, PaO2<75 mm Hg,pleural effusion, a history of asthma, smoking, drinking alcohol, coronary artery disease, diabetes mellitus, encephalopathy>grade 3, spontaneous bacterial peritonitis, preoperative MELD score, serum albumin, ascites≥20 ml/kg and moderate hepatopulmonary hypertension) and 7 intraoperative variables (duration of operation, duration of anhepatic stage, transfusions of RBC,fresh frozen plasma (FFP), crystalloid and colloid, and urine output< 1 ml·kg-1·h-1) were recorded and compared between the two groups.Results There were significant differences in 9 preoperative variables (age > 64 yr, PaO2<75 mm Hg, pleural effusion,encephalopathy>grade 3, spontaneous bacterial peritonitis, preoperative MELD score, serum albumin, ascites≥20 ml/kg and moderate hepato-pulmonary hypertension) and 5 intraoperative variables (transfusions of RBC, FFP, crystalloid and colloid, and urine output<1 mi·kg-1·h-1) between the two groups (P<0.05 or 0.01). And logistic regression analysis showed that 5preoperative variables (age>64 yr, PaO2<75

  20. Similarity of vegetation dynamics during interglacial periods

    Science.gov (United States)

    Cheddadi, Rachid; de Beaulieu, Jacques-Louis; Jouzel, Jean; Andrieu-Ponel, Valérie; Laurent, Jeanne-Marine; Reille, Maurice; Raynaud, Dominique; Bar-Hen, Avner

    2005-01-01

    The Velay sequence (France) provides a unique, continuous, palynological record spanning the last four climatic cycles. A pollen-based reconstruction of temperature and precipitation displays marked climatic cycles. An analysis of the climate and vegetation changes during the interglacial periods reveals comparable features and identical major vegetation successions. Although Marine Isotope Stage (MIS) 11.3 and the Holocene had similar earth precessional variations, their correspondence in terms of vegetation dynamics is low. MIS 9.5, 7.5, and especially 5.5 display closer correlation to the Holocene than MIS 11.3. Ecological factors, such as the distribution and composition of glacial refugia or postglacial migration patterns, may explain these discrepancies. Comparison of ecosystem dynamics during the past five interglacials suggests that vegetation development in the current interglacial has no analogue from the past 500,000 years. PMID:16162676

  1. Periodical multiphasic screening and lung cancer prevention.

    Science.gov (United States)

    Carel, R S

    1998-06-01

    The purpose of this work is to evaluate the utilization of information gathered by multiphasic screening with respect to lung cancer detection and smoking cessation techniques. A cohort (follow-up) study is reported in which cancer incidence and factors affecting its occurrence are evaluated in a group of about 20,000 presumably healthy adults along a period of approximately 10 years following comprehensive multiphasic health examinations. Lung cancer occurrence is primarily related to smoking. The risk is higher in smokers and is dose-dependent; OR = 0.21, (CI = 0.08, .53) in never smokers, OR = 1.53 (CI = 0.8, 3.2) in past and current moderate smokers, OR = 4.92 (CI = 2.18, 11.11) in current heavy smokers. Moreover, smokers with compromised pulmonary function (FEVI/FVC periodical multiphasic health examinations could be utilized by health professionals to encourage smoking cessation and smoking prevention in the appropriate screenees. Various elements of the multiphasic test results could contribute to such prevention efforts. While every smoker should receive appropriate evaluation and consultation regarding nicotine dependence, smokers with reduced pulmonary function represent an extra high risk group to which special attention should be given.

  2. A periodic table for cancer.

    Science.gov (United States)

    Epstein, Richard J

    2015-01-01

    Cancers exhibit differences in metastatic behavior and drug sensitivity that correlate with certain tumor-specific variables such as differentiation grade, growth rate/extent and molecular regulatory aberrations. In practice, patient management is based on the past results of clinical trials adjusted for these biomarkers. Here, it is proposed that treatment strategies could be fine-tuned upfront simply by quantifying tumorigenic spatial (cell growth) and temporal (genetic stability) control losses, as predicted by genetic defects of cell-cycle-regulatory gatekeeper and genome-stabilizing caretaker tumor suppressor genes, respectively. These differential quantifications of tumor dysfunction may in turn be used to create a tumor-specific 'periodic table' that guides rational formulation of survival-enhancing anticancer treatment strategies.

  3. Quasi Periodic Oscillations in Blazars

    Indian Academy of Sciences (India)

    Alok C. Gupta

    2014-09-01

    Here we report our recent discoveries of Quasi-Periodic Oscillations (QPOs) in blazars time series data in X-ray and optical electromagnetic bands. Any such detection can give important clues of the location and nature of the processes of emission mechanism. In the case of radio-quiet AGN, the detected QPOs are very likely to be associated with the accretion disk. But in the case of blazars, it may be associated with jets in the high and outburst states, and in the low-state, it is probably associated with the accretion disk. In this brief review, I summarize the recent QPO detections in blazars. There is one strong evidence of QPO detection in XMM–Newton time series data of narrow line Seyfert 1 galaxy RE J1034+396 about which we will also discuss briefly.

  4. A model for periodic blazars

    CERN Document Server

    Sobacchi, Emanuele; Stamerra, Antonio

    2016-01-01

    We describe a scenario to explain blazar periodicities with timescales of $\\sim$ few years. The scenario is based on a binary super-massive black hole (SMBH) system in which one of the two SMBH carries a jet. We discuss the various mechanisms that can cause the jet to precess and produce corkscrew patterns through space with a scale of $\\sim$ few pc. It turns out that the dominant mechanism responsible for the precession is simply the imprint of the jet-carrying SMBH orbital speed on the jet. Gravitational deflection and Lense-Thirring precession (due to the gravitational field of the other SMBH) are second order effects. We complement the scenario with a kinematical jet model which is inspired to the spine-sheath structure observed in M87. One of the main advantages of such a structure is that it allows the peak of the synchrotron emission to scale with frequency according to $\

  5. Optimization of dry period in Karan Fries cow

    Science.gov (United States)

    Japheth, K. Puhle; Mehla, R. K.; Singh, Mahendra; Gupta, A. K.; Das, Ramendra; Bharti, Pranay; Chandrasekar, T.

    2016-01-01

    Aim: The objective of this study was to optimize dry period (DP) length that can maximize the production across adjacent lactations and overall lifetime yield. Materials and Methods: Performance records with respect to DP spread over a period of 15-year in Karan Fries (KF) cattle maintained at Livestock Research Centre (National Dairy Research Institute), were collected for the study. Data of 681 KF cows were analyzed by least square technique to examine the effect of non-genetic factors on DP. Season of calving was classified into four seasons: Winter season (December-March), summer season (April-June), rainy season (July-September), and autumn season (October-November); period of calving into five periods: 1998-2000 (1-period), 2001-2003 (II-period), 2004-2006 (III-period), 2007-2009 (IV-period), and 2010-2012 (V-period), and parity into six parities, i.e., 1st, 2nd, 3rd, 4th, 5th, and >6th parities to see the effect of non-genetic factors on DP. Results: Period of calving, season of calving, and parity did not affect the DP significantly (p156 days), and optimum level was obtained at 46-67 days (3rd class) with the following respective milk yield (MY) of 305 daily MY (4016.44±43.68 kg), total MY (4704.21±61.51 kg), MY per day of lactation length (13.03±0.13 kg), and MY per day of calving interval (11.68±0.41 kg). Conclusion: From the study, it was concluded that this optimal DP length (46-67 days) is suitable for maximizing the production. Hence, one should aim to dry off pregnant cows to achieve a DP of appropriate length to enhance productivity in the next lactation, as very short and very long DP reduces the economic profitability in dairy animals. PMID:27397990

  6. 1 ∶ 2 matched case-control study on the risk factors related to congenital heart disease during the peri-conceptional period%围孕期先天性心脏病危险因素的1∶2配比病例对照研究

    Institute of Scientific and Technical Information of China (English)

    李侠; 谢胜男; 王寅; 王建敏; 凌子羽; 纪昌文; 张清凯; 杨森焙; 张静

    2014-01-01

    目的 探讨围孕期环境暴露因素与先天性心脏病(CHD)发生风险之间的关系.方法 采用1∶2配比的病例对照研究方法,于2012年1月至2014年1月对武汉市某区妇幼机构儿童进行“CHD免费筛查”,通过常规听诊、超声心动图初筛,并经市级以上医院确诊.以CHD患儿为病例组,按照年龄、性别、社区配对选择健康的儿童为对照组.用EpiData 3.1软件录入数据,用SPSS 11.5软件进行单因素和多因素的条件logistic回归分析.结果 采集138名患儿和276名对照儿童的父母信息.对27个主要研究因素进行单因素条件logistic回归分析.结果显示,孕早期补钙、孕早期精神刺激、母亲孕期营养、不良孕产史、经产妇、围孕期患病及居住地附近有污染企业与子代CHD发生有一定关联;多因素条件logistic回归分析显示,孕早期精神刺激(HR=3.35,95%CI:1.28 ~ 8.79)、母亲孕期营养不良(HR=1.50,95%CI:1.10 ~ 2.03)及不良孕产史(HR=1.62,95%CI:1.03 ~ 2.57)是子代发生CHD的危险因素,而孕早期适当补钙(HR=0.40,95%CI:0.25~0.65)则可降低CHD发生的风险.结论 CHD的发生可能与孕早期精神刺激、围孕期营养、孕早期补钙及既往不良生育史有一定关系,应加强围孕期保健,降低CHD的发病率.%Objective To explore the possible risk factors during the periconceptional period relevant on the occurrence of congenital heart diseases (CHD) in the offspring.Methods A 1 ∶ 2matched case-control study was designed.From January 2012 to January 2014 in a district from Wuhan city,HuBei province,children were proved by MCH institutions through the "free screening for congenital heart disease" program.Cases with CHD were screened out by conventional auscultation,echocardiography figure and confirmed by physicians from the high-level hospitals.According to age,gender,community paired healthy children were chosen as controls.EpiData 3.1 software was used to input data

  7. Fatores de risco associados à mortalidade de recém-nascidos de muito baixo peso na cidade de Botucatu, São Paulo, no período 1995-2000 Risk factors for mortality in very low birth-weight infants in the city of Botucaty, State of São Paulo, during the period 1995-2000

    Directory of Open Access Journals (Sweden)

    Maria Laura H. Prigenzi

    2008-03-01

    Full Text Available OBJETIVOS: avaliar as práticas assistenciais, a ocorrência de doenças, a mortalidade durante a hospitalização e os fatores associados em recém-nascidos prematuros de muito baixo peso (PT-MBP. MÉTODOS: estudo transversal comparando dois períodos: 1995-1997 e 1998-2000 e envolvendo todos os PT-MBP nascidos vivos (n= 451, em um centro perinatal, em Botucatu, São Paulo, Brasil. Os fatores de risco pré-natal e pós-natal foram submetidos a análise multivariada. RESULTADOS: a mortalidade diminuiu de 36,2% para 29,5%. A sobrevida melhorou e foi superior a 50% a partir de 28 semanas e de 750 g de peso. O uso de corticosteróide antenatal aumentou de 25% para 42%, o surfactante exógeno de 14% para 28%, com redução na incidência e gravidade da síndrome do desconforto respiratório. A regressão logística mostrou que a síndrome do desconforto respiratório grave, Odds ratio=18, e a sepse precoce, Odds ratio=2,8, foram importantes fatores de risco para morte em 1995-1997. No período de 1998-2000, a sepse precoce e tardia, Odds ratio=10,5 e 12, respectivamente, aumentaram o risco de morte. CONCLUSÕES: a melhora na assistência perinatal diminuiu a mortalidade do PT-MBP. O aumento na exposição antenatal ao corticosteróide diminuiu a gravidade da síndrome do desconforto respiratório. Em 1998-2000, a sepse foi o único fator de risco para morte.OBJECTIVES: to evaluate perinatal care, the incidence of diseases, and mortality during hospitalization and associated risk factors in very low birth-weight infants (VLBW. METHODS: a cross sectional survey comparing two periods: 1995-1997 and 1998-2000, including all live-born VLBW preterm infants (n= 451, delivered at a level III perinatal center in the city of Botucatu, State of São Paulo, Brazil. The antenatal and postnatal risk factors were analyzed using multivariable techniques. RESULTS: mortality decreased from 36.2% to 29.5%. The survival of infants 750 g, and 28 weeks' gestation

  8. Comparative study of thyrotoxic periodic paralysis from idiopathic hypokalemic periodic paralysis: An experience from India.

    Science.gov (United States)

    Kalita, J; Goyal, G; Bhoi, S K; Chandra, S; Misra, U K

    2012-07-01

    There is paucity of reports on thyrotoxic periodic paralysis (TPP) from India. We report the patients with TPP and compare them with idiopathic hypokalemic periodic paralysis (IHPP). Patients with hypokalemic periodic paralysis (HPP) treated during the past 11 years were evaluated retrospectively. Their demographic parameters, family history, clinical features, precipitating factors, severity of weakness, laboratory parameters and rapidity of recovery were recorded. The demographic, clinical and laboratory parameters of TPP and IHPP were compared. During the study period, we managed 52 patients with HPP; nine (17.3%) of whom had TPP and 27 (52%) had IHPP. The demographic, precipitating factors, number of attacks and severity of limb weakness were similar between the TPP and IHPP groups, except in the IHPP group, bulbar weakness was present in four and respiratory paralysis in six, needing artificial ventilation in two patients. Serum potassium was significantly lower in TPP (2.21 ± 0.49) compared with IHPP (2.67 ± 0.59, P = 0.04). Four patients with TPP had subclinical thyrotoxicosis and two had subclinical hyperthyroidism. Rebound hyperkalemia occurred in both TPP and IHPP (three versus eight patients). The recovery was faster in IHPP (26.7 ± 15.4 h) compared with TPP (34.0 ± 14.0 h), but was statistically insignificant. TPP constitutes 17.3% of HPP, and absence of clinical features of thyrotoxicosis and subclinical hyperthyroidism in TPP is not uncommon. Clinical features, demographic profile and rebound hyperkalemia are similar in both TPP and IHPP. The serum potassium level is significantly low in the TPP compared with the IHPP group.

  9. Comparative study of thyrotoxic periodic paralysis from idiopathic hypokalemic periodic paralysis: An experience from India

    Directory of Open Access Journals (Sweden)

    J Kalita

    2012-01-01

    Full Text Available Objective: There is paucity of reports on thyrotoxic periodic paralysis (TPP from India. We report the patients with TPP and compare them with idiopathic hypokalemic periodic paralysis (IHPP. Materials and Methods: Patients with hypokalemic periodic paralysis (HPP treated during the past 11 years were evaluated retrospectively. Their demographic parameters, family history, clinical features, precipitating factors, severity of weakness, laboratory parameters and rapidity of recovery were recorded. The demographic, clinical and laboratory parameters of TPP and IHPP were compared. Results: During the study period, we managed 52 patients with HPP; nine (17.3% of whom had TPP and 27 (52% had IHPP. The demographic, precipitating factors, number of attacks and severity of limb weakness were similar between the TPP and IHPP groups, except in the IHPP group, bulbar weakness was present in four and respiratory paralysis in six, needing artificial ventilation in two patients. Serum potassium was significantly lower in TPP (2.21 ± 0.49 compared with IHPP (2.67 ± 0.59, P = 0.04. Four patients with TPP had subclinical thyrotoxicosis and two had subclinical hyperthyroidism. Rebound hyperkalemia occurred in both TPP and IHPP (three versus eight patients. The recovery was faster in IHPP (26.7 ± 15.4 h compared with TPP (34.0 ± 14.0 h, but was statistically insignificant. Conclusion: TPP constitutes 17.3% of HPP, and absence of clinical features of thyrotoxicosis and subclinical hyperthyroidism in TPP is not uncommon. Clinical features, demographic profile and rebound hyperkalemia are similar in both TPP and IHPP. The serum potassium level is significantly low in the TPP compared with the IHPP group.

  10. “和谐使命”-2013任务中女舰员生理周期变化及影响因素分析%The analysis of menstrual cycle changes and influence factors to the menstrual period in the female crews during the long voyage in Mission harmony-2013

    Institute of Scientific and Technical Information of China (English)

    谢学渊; 张兰梅; 郑路平; 沈晶晶; 夏松云

    2015-01-01

    目的:调查和谐使命-2013任务中女舰员生理周期变化情况,分析可能的影响因素,探寻女舰员长航后生理周期变化的规律。方法通过问卷调查方法调查女舰员在长航前、长航3月后月经情况,对不同年龄、婚姻状态、学历、职业的女舰员月经情况进行分析。任务结束3月后,对发生生理周期紊乱的女舰员通过电话随访了解其月经恢复情况。选取20名年轻女舰员,分别于长航前及长航3月后抽血行性激素水平检测。结果长航3月后女舰员月经紊乱发生率为18.1%,机关女干部组月经紊乱发生率明显高于战士及医务人员组;年龄、学历、婚姻状态对月经周期无明显影响;所有长航中发生月经紊乱者在任务结束3月后月经均恢复正常。长航后女舰员性激素水平无显著差异。结论女舰员在执行长航任务中可能会出现短暂的月经周期紊乱,任务结束后短期内月经即可恢复正常。%Objective To investigate the female crew’s menstrual cycle changes during the voyage of Mission Harmony -2013 and explored the menstruation change rules by analyzing those possible influence factors to the menstrual period. Methods Menstrual cycle changes were surveyed with a questionnaire method for those female crews before the sailing of the voyage and 3 months after the navigation. Age difference, marital status, education and occupation were considered in the analysis for female crews’period changes. All the female crews with menstrual cycle disorders during voyage were follow-up in 3 months after the end of mission. The serum levels of sex hormones were tested in 20 younger crew members prior to sailing and 3 months after the navigation separately. Results The total incidence of menstrual disorders in the female crews was 18.5% after three months long voyage in Mission harmony 2013. The study demonstrated that the incidence of menstrual disorder in organs of women

  11. Analysis of Spontaneousness and Social Factor of Forming Xishui “Industrial Park” in the Qian-Jia period in the Qing Dynasty%乾嘉时期习水“工业园区”形成的自然、社会因素探析

    Institute of Scientific and Technical Information of China (English)

    黎洌

    2015-01-01

    清乾隆嘉庆时,袁锦道在习水三岔河新建了数十间工业作坊,为封闭的黔北开启通往现代化的大门。从康熙二十年后黔北长期的社会稳定和经济繁荣是袁锦道成功的经济基础,赤水河流域的自然生态条件及形成的人文环境是重要的文化和物质基础,而人口的迅猛增长和交通条件的改善为劳动力的转移和产品的销售提供了有利的契机。正是各种因素的聚合和敏锐的前瞻意识,成就了袁锦道的事业,成为黔北历史辉煌的一页。%In the Qian -Jia period in the Qing Dynasty, Yuan Jindao established tens of industrial workshops on the Sishui Sancha River, making the then quite closed north area of Guizhou open to mod-ernization. In over 20 years of Kang Xi power, the social stability of long standing and economic flourish formed the economic base of Yuan Jindao’ s success. The natural ecology along the Chishui Valye and humanity environment it formed were the important cultural and material basis of his success and the speedy growth of population and improvement of traffic condition provided opportunities for the transfer of labour power and the sale of products. It is because of the aggregation of many factors and his acute pre-monitory sense that made Yuan Jindao’ s undertaking successful, leaving a glorious page in the history of the north area of Guizhou.

  12. Statistical methods for detecting periodic fragments in DNA sequence data

    Directory of Open Access Journals (Sweden)

    Ying Hua

    2011-04-01

    Full Text Available Abstract Background Period 10 dinucleotides are structurally and functionally validated factors that influence the ability of DNA to form nucleosomes, histone core octamers. Robust identification of periodic signals in DNA sequences is therefore required to understand nucleosome organisation in genomes. While various techniques for identifying periodic components in genomic sequences have been proposed or adopted, the requirements for such techniques have not been considered in detail and confirmatory testing for a priori specified periods has not been developed. Results We compared the estimation accuracy and suitability for confirmatory testing of autocorrelation, discrete Fourier transform (DFT, integer period discrete Fourier transform (IPDFT and a previously proposed Hybrid measure. A number of different statistical significance procedures were evaluated but a blockwise bootstrap proved superior. When applied to synthetic data whose period-10 signal had been eroded, or for which the signal was approximately period-10, the Hybrid technique exhibited superior properties during exploratory period estimation. In contrast, confirmatory testing using the blockwise bootstrap procedure identified IPDFT as having the greatest statistical power. These properties were validated on yeast sequences defined from a ChIP-chip study where the Hybrid metric confirmed the expected dominance of period-10 in nucleosome associated DNA but IPDFT identified more significant occurrences of period-10. Application to the whole genomes of yeast and mouse identified ~ 21% and ~ 19% respectively of these genomes as spanned by period-10 nucleosome positioning sequences (NPS. Conclusions For estimating the dominant period, we find the Hybrid period estimation method empirically to be the most effective for both eroded and approximate periodicity. The blockwise bootstrap was found to be effective as a significance measure, performing particularly well in the problem of

  13. Mutational spectrum in the MEFV and TNFRSF1A genes in patients suffering from AA amyloidosis and recurrent inflammatory attacks

    NARCIS (Netherlands)

    Dode, C; Hazenberg, BPC; Pecheux, C; Cattan, D; Moulin, B; Barthelemy, A; Gubler, MC; Delpech, M; Grateau, G

    Background. Among hereditary fevers characterized by recurrent attacks of fever and organ localized inflammation, familial Mediterranean fever (FMF). and tumour necrosis factor receptor superfamily 1A (TNFRSF1A) receptor associated periodic syndrome (TRAPS) are diseases with identified genes that

  14. Periodicities of hail precipitation in France

    Science.gov (United States)

    Hermida, Lucía; Sánchez, José Luis; Berthet, Claude; Dessens, Jean; López, Laura; Hierro, Rodrigo; Wu, Xueke; García-Ortega, Eduardo

    2013-04-01

    The wavelet analysis is a powerful tool appropriated for studying multiscale and non-stationary processes that occur in finite spatial and temporal domains. Its development began with Morlet and, since then, the wavelet transform (WT) has had better applications in Geophysics. However, the characterization of hail precipitation is not exempt from difficulty, since it deals with phenomenon on a small scale, with elevated spatial and temporal variation. The extreme variability of the frequency and distribution of hail is attributed, among other things, to the same process of its formation. The conditions that influence hail formation span from air masses climatology to lower-scale factors such as orography, wind fields, concentration of ice nuclei or temperature. This last factor is important both from a point of view of convective activity as well as its influence in the height of the freezing point. Thus, it would be possible to do comparative analysis between time series of temperature and diverse hail variables; or, rather, to try to establish a relationship between periodicities found and phenomenon such as ENSO (El Niño, Southern Oscillation) or NAO (North-Atlantic Oscillation). France is one of the European countries that is most affected by hail precipitation. Previous climatic studies have been done with the objective of characterizing the long-term variability of distinct variables of this hydrometeor that is present in the time series. These measurements are obtained using networks of hailpads distributed in French territory and managed by ANELFA. Berthet et al. (2011) observed the annual hail frequency in France, finding successions of three years with high values followed by three years of low values; this being calculated as the number of hailfalls per year divided by the number of hailpad stations that were in use during said year. In the present paper, a wavelet analysis was carried out with the objective of detecting the possible existence of

  15. Molecular basis for hyperkalemic periodic paralysis.

    Science.gov (United States)

    Brown, R H

    At least one form of periodic paralysis is a direct consequence of a mutation in a skeletal muscle, voltage-sensitive sodium channel--it was observed that many individual with this disease developed low serum potassium levels during paralytic episodes. Some families had hyperkalemic paralysis with serum potassium levels of 6 or 7 mEg/L during paralytic crises. In both hypokalemic and hyperkalemic paralysis one of the precipitants is a period of rest after exertion. In hypokalemic periodic paralysis carbohydrates may initiate weakness. In both hyper- and hypokalemic forms, the disorder is inherited as an autosomal dominant trait. During hypokalemic and hyperkalemic paralysis, one might respectively anticipate muscle hyperpolarization or depolarization. Has been observed a potassium-related abnormality of sodium conductance in the pathogenesis at least of the hyperkalemic form of periodic paralysis. The fact that TTX reverses the physiological defect suggested the hypothesis that the primary problem might be a mutation in a TTX-sensitive sodium channel. The protein consists of some 2000 amino acids with characteristic intracytoplasmic and extracellular domains as well a four remarkably conserved membrane spanning domains, each composed of six transmembrane of a polymorphism of the human sodium channel with hyperkalemic paralysis. When multipoint analysis was used to test for coinheritance of the disease with both Na-2 and growth hormone polymorphisms, a lod score of 7 was obtained. That is, the ratio of the probability of linkage to non-linkage is 10 million to one. When extracellular potassium is increased to 10 mM, the affected myotubes demonstrate strikingly abnormal channel behavior characterized by prolonged open times or repetitive opens throughout the voltage step. Potassium implicate as a primary factor triggering an abnormal sodium channel gating mode and, as a result, aberrant sodium current behavior. It was estimated that, for the normal channel, the

  16. The attitudes of women towards family planning and related factors in the postpartum periodDoğum sonu dönemdeki kadınların aile planlaması konusundaki tutumları ve ilişkili faktörler

    Directory of Open Access Journals (Sweden)

    Nergiz Eryılmaz

    2016-08-01

    Full Text Available An early second pregnancy after birth may negatively influence the health of the first child and mother. Most of the women want to delay or prevent future pregnancies during the postpartum period. The postpartum is a very important period of preventing unwanted pregnancies. In postpartum period, use of contraceptive is connected with women’s cultural and religious believes, partner’s attitudes and previous contraceptive experiences. Family planning training in prenatal and postnatal period is considered as a standard care. The aim of the study is to determine the attitudes of women towards family planning and related factors in the postpartum period. This study is done as a descriptive research in the postpartum period. The samples consist of 272 women in the postpartum period. "Family Planning Attitude Scale" (FPAS and personal information questionnaire prepared by the researchers have been used to collect the data. In the analysis of data; Number, percentage, mean and standard deviation, Mann-Whitney U and Kruskal-Wallis test were used for the analysis of the data. It was found out that mean age of the postpartum women was 26.30±5.60 years and mean marriage duration (year was 5.84±4.92. It was noted that 72.8% of women planned to last pregnancy and 52,6% of them don’t want to do pregnancy again. It was determined that 47,8% of women’s source of information about family planning (FP was the health professional and 76,1% of them received counseling about FP. 94,9% of postpartum women want to use contraceptive method until they decide a new pregnancy .Significant differences were detected between postpartum women; education  (Z=-3.320; p:0.001, employment status (Z=-4.741; p:0.000, social security (Z=-4.569; p:0.000, family type (Z=-4.086; p:0.000, perception of economic status (KW=8402; p:0.015 getting counseling service about family planning  (Z=2.841; p=0.004, and using family planning in the postnatal period. (Z=-4.741; p:0

  17. Time—periodic weak solutions

    Directory of Open Access Journals (Sweden)

    Eliana Henriques de Brito

    1990-01-01

    Full Text Available In continuing from previous papers, where we studied the existence and uniqueness of the global solution and its asymptotic behavior as time t goes to infinity, we now search for a time-periodic weak solution u(t for the equation whose weak formulation in a Hilbert space H isddt(u′,v+δ(u′,v+αb(u,v+βa(u,v+(G(u,v=(h,vwhere: ′=d/dt; (′ is the inner product in H; b(u,v, a(u,v are given forms on subspaces U⊂W, respectively, of H; δ>0, α≥0, β≥0 are constants and α+β>0; G is the Gateaux derivative of a convex functional J:V⊂H→[0,∞ for V=U, when α>0 and V=W when α=0, hence β>0; v is a test function in V; h is a given function of t with values in H.

  18. 7 CFR 953.122 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 953.122 Section 953.122 Agriculture... STATES Rules and Regulations Change in Date for Completing Nominations, Term of Office, and Fiscal Period § 953.122 Fiscal period. The fiscal period, pursuant to § 953.9, which began on April 1, 1976, shall...

  19. 7 CFR 947.9 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 947.9 Section 947.9 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Definitions § 947.9 Fiscal period. Fiscal period means the period beginning and ending on the dates...

  20. 7 CFR 923.7 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 923.7 Section 923.7 Agriculture... COUNTIES IN WASHINGTON Order Regulating Handling Definitions § 923.7 Fiscal period. Fiscal period is synonymous with fiscal year and means the 12-month period ending on March 31 of each year or such...

  1. 7 CFR 966.16 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 966.16 Section 966.16 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 966.16 Fiscal period. Fiscal period means the period beginning August 1...

  2. 7 CFR 948.10 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 948.10 Section 948.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Regulating Handling Definitions § 948.10 Fiscal period. Fiscal period means the period...

  3. 7 CFR 922.7 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 922.7 Section 922.7 Agriculture... IN WASHINGTON Order Regulating Handling Definitions § 922.7 Fiscal period. Fiscal period is synonymous with fiscal year and means the 12-month period ending on March 31 of each year or such...

  4. 7 CFR 1221.10 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Fiscal period. 1221.10 Section 1221.10 Agriculture... INFORMATION ORDER Sorghum Promotion, Research, and Information Order Definitions § 1221.10 Fiscal period. Fiscal period means the 12-month period ending on December 31 or such other consecutive 12-month...

  5. 7 CFR 1230.9 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Fiscal period. 1230.9 Section 1230.9 Agriculture... CONSUMER INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.9 Fiscal period. Fiscal period means the 12-month period ending on December 31 or such other consecutive...

  6. 7 CFR 1220.111 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Fiscal period. 1220.111 Section 1220.111 Agriculture... CONSUMER INFORMATION Soybean Promotion and Research Order Definitions § 1220.111 Fiscal period. The term fiscal period means the calendar year or such other annual period as the Board may determine with...

  7. 7 CFR 924.7 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 924.7 Section 924.7 Agriculture... COUNTIES IN WASHINGTON AND IN UMATILLA COUNTY, OREGON Order Regulating Handling Definitions § 924.7 Fiscal period. Fiscal period is synonymous with fiscal year and means the 12-month period ending on March 31...

  8. 7 CFR 948.103 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 948.103 Section 948.103 Agriculture... Rules and Regulations General § 948.103 Fiscal period. Pursuant to § 948.10, the fiscal periods for each... following year, both dates inclusive. The 1986-87 fiscal period which began July 1, 1986, will be...

  9. 7 CFR 946.9 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 946.9 Section 946.9 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Regulating Handling Definitions § 946.9 Fiscal period. Fiscal period means the period beginning...

  10. 7 CFR 1218.8 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Fiscal period. 1218.8 Section 1218.8 Agriculture... INFORMATION ORDER Blueberry Promotion, Research, and Information Order Definitions § 1218.8 Fiscal period. Fiscal period means a calendar year from January 1 through December 31, or such other period as...

  11. 7 CFR 929.6 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 929.6 Section 929.6 Agriculture... LONG ISLAND IN THE STATE OF NEW YORK Order Regulating Handling Definitions § 929.6 Fiscal period. Fiscal period is synonymous with fiscal year and crop year and means the 12-month period...

  12. 7 CFR 956.113 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 956.113 Section 956.113 Agriculture... VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.113 Fiscal period. Pursuant to § 956.13, fiscal period shall mean the period beginning January 1 and ending December 31...

  13. 7 CFR 927.9 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 927.9 Section 927.9 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Regulating Handling Definitions § 927.9 Fiscal period. Fiscal period means the period...

  14. 7 CFR 959.16 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 959.16 Section 959.16 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 959.16 Fiscal period. Fiscal period means the annual period beginning...

  15. 7 CFR 917.9 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 917.9 Section 917.9 Agriculture... CALIFORNIA Order Regulating Handling Definitions § 917.9 Fiscal period. Fiscal period is synonymous with fiscal year and means the 12-month period ending on the last day of February of each year, or such...

  16. 7 CFR 945.12 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 945.12 Section 945.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Fiscal period. Fiscal period means the period beginning and ending on the dates approved by the...

  17. 7 CFR 958.12 - Fiscal period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 958.12 Section 958.12 Agriculture... COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 958.12 Fiscal period. Fiscal period means the period beginning and ending on the dates approved by the Secretary pursuant...

  18. 30 CFR 887.13 - Grant period.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Grant period. 887.13 Section 887.13 Mineral... LAND RECLAMATION SUBSIDENCE INSURANCE PROGRAM GRANTS § 887.13 Grant period. The grant funding period... remaining at the end of any grant period to us according to 43 CFR part 12. ...

  19. 7 CFR 1280.611 - Representative period.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Representative period. 1280.611 Section 1280.611... INFORMATION ORDER Procedures To Request a Referendum Definitions § 1280.611 Representative period. Representative period means the period designated by the Secretary pursuant to § 518 of the Act. ...

  20. 42 CFR 413.239 - Transition period.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Transition period. 413.239 Section 413.239 Public...) Services and Organ Procurement Costs § 413.239 Transition period. (a) Duration of transition period and... § 413.171, furnished during the transition period, new ESRD facilities as defined in § 413.171, are paid...