WorldWideScience

Sample records for factor analysis generated

  1. A Second Generation Nonlinear Factor Analysis.

    Science.gov (United States)

    Etezadi-Amoli, Jamshid; McDonald, Roderick P.

    1983-01-01

    Nonlinear common factor models with polynomial regression functions, including interaction terms, are fitted by simultaneously estimating the factor loadings and common factor scores, using maximum likelihood and least squares methods. A Monte Carlo study gives support to a conjecture about the form of the distribution of the likelihood ratio…

  2. Factors influencing municipal solid waste generation in China: a multiple statistical analysis study.

    Science.gov (United States)

    Liu, Chen; Wu, Xin-wu

    2011-04-01

    A relationship between the waste production and socio-economic factors is essential in waste management. In the present study, the factors influencing municipal solid waste generation in China were investigated by multiple statistical analysis. Twelve items were chosen for investigation: GDP, per capita GDP, urban population, the proportion of urban population, the area of urban construction, the area of paved roads, the area of urban gardens and green areas, the number of the large cities, annual per capita disposable income of urban households, annual per capita consumption expenditure of urban households, total energy consumption and annual per capital consumption for households. Two methodologies from multiple statistical analysis were selected; specifically principal components analysis (PCA) and cluster analysis (CA). Three new dimensions were identified by PCA: component 1: economy and urban development; component 2: energy consumption; and component 3: urban scale. The three components together accounted for 99.1% of the initial variance. The results show that economy and urban development are important items influencing MSW generation. The proportion of urban population and urban population had the highest loadings in all factors. The relationship between growth of gross domestic product (GDP) and production of MSW was not as clear-cut as often assumed in China, a situation that is more likely to apply to developed countries. Energy consumption was another factor considered in our study of MSW generation. In addition, the annual MSW quantity variation was investigated by cluster analysis.

  3. Reaction mechanism and influence factors analysis for calcium sulfide generation in the process of phosphogypsum decomposition

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Liping, E-mail: lpma2522@hotmail.com [Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650093 (China); Niu, Xuekui; Hou, Juan; Zheng, Shaocong; Xu, Wenjuan [Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650093 (China)

    2011-11-10

    Highlights: Black-Right-Pointing-Pointer Reusing phosphogypsum is to decompose and recycle Ca and sulfur. Black-Right-Pointing-Pointer FactSage6.1 software was used to simulate the decomposition reactions. Black-Right-Pointing-Pointer Experiments had been taken with high sulfur concentration coal as reducing agent. Black-Right-Pointing-Pointer The reaction mechanism of CaS generation had been analysis, 1100 Degree-Sign C could be the best temperature for PG decomposition. - Abstract: FactSage6.1 software simulation and experiments had been used to analysis the reaction mechanism and influence factors for CaS generation during the process of phosphogypsum decomposition. Thermodynamic calculation showed that the reaction for CaS generation was very complex and CaS was generated mainly through solid-solid reaction and gas-solid reaction. The proper CO and CO{sub 2} have benefit for improving the decomposition effects of phosphogypsum and reducing the generation of CaS at 1100 Degree-Sign C. Using high sulfur concentration coal as reducer, the proper reaction conditions to control the generation of CaS were: the coal particle size was between 60 mesh and 100 mesh, reaction temperature was above 1100 Degree-Sign C and the heating rate was 5 Degree-Sign C/min. Experimental and theoretical calculation indicated that the concentration of CaS was only ten percents in the solid product at 1100 Degree-Sign C, which is favorable for the further cement producing using solid production.

  4. Modeling and analysis of PM2.5 generation for key factors identification in China

    Science.gov (United States)

    Xia, Dehong; Jiang, Binfan; Xie, Yulei

    2016-06-01

    Recently, the PM2.5 pollution in China has occurred frequently and caused widely concern. In order to identify the key factors for PM2.5 generation, the formation characteristics of PM2.5 would be revealed. A property of electric neutrality of PM2.5 was proposed under the least-energy principle and verified through electricity-charge calculation in this paper. It indicated that PM2.5 is formed by the effect of electromagnetic force, including the effect of ionic bond, hydrogen bond and polarization. According to the analysis of interactive forces among different chemical components, a simulation model is developed for describing the random process of PM2.5 generation. In addition, an orthogonal test with two levels and four factors has been designed and carried out through the proposed model. From the text analysis, PM2.5 would be looser and suspend longer in atmosphere due to Organic Compound (OC) existing (OC can reduce about 67% of PM2.5 density). Considering that NH4+ is the only cation in the main chemical components of PM2.5, it would be vital for anions (such as SO42- and NO3-) to aggregate together for facilitating PM2.5 growing. Therefore, in order to relieve PM2.5 pollution, control strategies for OC and NH4+ would be enhanced by government through improving the quality of oils and solvent products, decreasing the amount of nitrogenous fertilizer utilization, or changing the fertilizing environment from dry condition to wet condition.

  5. Kinetic Model Facilitates Analysis of Fibrin Generation and Its Modulation by Clotting Factors: Implications for Hemostasis-Enhancing Therapies

    Science.gov (United States)

    2014-01-01

    facilitates analysis of fibrin generation and its modulation by clotting factors: implications for hemostasis-enhancing therapies† Alexander Y...Syst. Biol.Med., 2011, 3, 136–146. 62 M. Schneider, N. Brufatto, E. Neill and M. Nesheim, J. Biol. Chem., 2004, 279, 13340–13345. 63 J. H. Foley, P. F

  6. Sensitivity Analysis on the Impact Factors of the GSHP System Considering Energy Generation and Environmental Impact Using LCA

    Directory of Open Access Journals (Sweden)

    Taehoon Hong

    2016-04-01

    Full Text Available The world is facing a crisis due to energy depletion and environmental pollution. The ground source heat pump (GSHP system, the most efficient new/renewable energy (NRE system that can reduce the load of heating/cooling equipment in a building, can be used to address this crisis. Designers and contractors have implemented such systems depending on their experience, although there are many factors that affect the performance of the GSHP system. Therefore, this study aimed to conduct a sensitivity analysis on the impact factors in terms of energy generation and environmental impact. This study was conducted as follows: (i collecting the impact factors that affect the GSHP system’s performance; (ii establishing the GSHP system’s scenarios with the impact factors; (iii determining the methodology and calculation tool to be used for conducting sensitivity analysis; and (iv conducting sensitivity analysis on the impact factors of the GSHP system in terms of energy generation and environmental impact using life cycle assessment. The results of this study can be used: (i to establish the optimal design strategy for different application fields and different seasons; and (ii to conduct a feasibility study on energy generation and environmental impact at the level of the life cycle.

  7. Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Hui [Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (United States); Luthra, Rajyalakshmi, E-mail: rluthra@mdanderson.org; Goswami, Rashmi S.; Singh, Rajesh R. [Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (United States); Roy-Chowdhuri, Sinchita [Department of Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 (United States)

    2015-08-28

    Application of next-generation sequencing (NGS) technology to routine clinical practice has enabled characterization of personalized cancer genomes to identify patients likely to have a response to targeted therapy. The proper selection of tumor sample for downstream NGS based mutational analysis is critical to generate accurate results and to guide therapeutic intervention. However, multiple pre-analytic factors come into play in determining the success of NGS testing. In this review, we discuss pre-analytic requirements for AmpliSeq PCR-based sequencing using Ion Torrent Personal Genome Machine (PGM) (Life Technologies), a NGS sequencing platform that is often used by clinical laboratories for sequencing solid tumors because of its low input DNA requirement from formalin fixed and paraffin embedded tissue. The success of NGS mutational analysis is affected not only by the input DNA quantity but also by several other factors, including the specimen type, the DNA quality, and the tumor cellularity. Here, we review tissue requirements for solid tumor NGS based mutational analysis, including procedure types, tissue types, tumor volume and fraction, decalcification, and treatment effects.

  8. Analysis of Pre-Analytic Factors Affecting the Success of Clinical Next-Generation Sequencing of Solid Organ Malignancies

    Directory of Open Access Journals (Sweden)

    Hui Chen

    2015-08-01

    Full Text Available Application of next-generation sequencing (NGS technology to routine clinical practice has enabled characterization of personalized cancer genomes to identify patients likely to have a response to targeted therapy. The proper selection of tumor sample for downstream NGS based mutational analysis is critical to generate accurate results and to guide therapeutic intervention. However, multiple pre-analytic factors come into play in determining the success of NGS testing. In this review, we discuss pre-analytic requirements for AmpliSeq PCR-based sequencing using Ion Torrent Personal Genome Machine (PGM (Life Technologies, a NGS sequencing platform that is often used by clinical laboratories for sequencing solid tumors because of its low input DNA requirement from formalin fixed and paraffin embedded tissue. The success of NGS mutational analysis is affected not only by the input DNA quantity but also by several other factors, including the specimen type, the DNA quality, and the tumor cellularity. Here, we review tissue requirements for solid tumor NGS based mutational analysis, including procedure types, tissue types, tumor volume and fraction, decalcification, and treatment effects.

  9. Factor analysis

    CERN Document Server

    Gorsuch, Richard L

    2013-01-01

    Comprehensive and comprehensible, this classic covers the basic and advanced topics essential for using factor analysis as a scientific tool in psychology, education, sociology, and related areas. Emphasizing the usefulness of the techniques, it presents sufficient mathematical background for understanding and sufficient discussion of applications for effective use. This includes not only theory but also the empirical evaluations of the importance of mathematical distinctions for applied scientific analysis.

  10. Next-Generation Retailing In India: An Empirical Study Using Factor Analysis

    Directory of Open Access Journals (Sweden)

    Manju Smita Dash

    2011-01-01

    Full Text Available The retail landscape in India is changing rapidly and is being scrutinized by large scale investments by foreign and domestic players. Market liberalization and changing consumer behaviour have sown the seeds of a retail transformation. Indian retailing is growing fast and imparting the consumer preferences across the country. Today retailing is largest contributing sector to country's GDP i.e. 10% as compared to 8% in China, 6% in Brazil. Modern retailing is capable of generating employment opportunities for 2.5 million people by 2010 in various retail operations and over 10 million additional workforces in retail support activities. Organised retail which presently account for only 4-6 percent of the total market is likely to increase its share to over 30% by 2013.It offers huge potential for growth in coming years. India is becoming most favoured retail destination in the world.

  11. MACROECONOMIC DETERMINANTS OF TOTAL FACTOR PRODUCTIVITY: NEW GENERATION PANEL DATA ANALYSIS ON OECD COUNTRIES (1996-2015

    Directory of Open Access Journals (Sweden)

    ÖMER YALÇINKAYA

    2016-12-01

    Full Text Available Determining the factors which are effective on total factor productivity (TFP increments include the productivity of all factors in the production process and making improvements for these factors via policies have importance concerning speed the potential growth rate up in the long term and making this sustainable. The mediumlong term determinants of TFP are examined in this research for the 1994-2015 period as econometric within the scope of new generation panel data analysis on the OECD countries who are classified as OECD-1 and OECD-2 by their income levels. From this aspect, purposed in this research that to reveal the primary determinants which cause the differentiations between OECD-1 and OECD-2 countries in terms of their long-term economic growth performances and/or income levels. Determined as a result of the research that the effect of the variables which are used to determine the medium-long term determinants of the TFP on OECD-1 and OECD-2 groups parallelly increased and decreased as long as enhancing the representation degree of the knowledge, innovation and technological development level of the variables. These results show that the differentiation of countries in OECD-1 and OECD-2 groups in terms of long-term economic growth and/or income levels is majorly rooted in indicators which are used on behalf of knowledge, innovation, and technological development.

  12. Factors affecting the rural domestic waste generation

    Directory of Open Access Journals (Sweden)

    A.R. Darban Astane

    2017-12-01

    Full Text Available The current study was carried out to evaluate the quantity and quality of rural domestic waste generation and to identify the factors affecting it in rural areas of Khodabandeh county in Zanjan Province, Iran. Waste samplings consisted of 318 rural households in 11 villages. In order to evaluate the quality and quantity of the rural domestic waste, waste production was classified into 12 groups and 2 main groups of organic waste and solid waste. Moreover, kriging interpolation technique in ARC-GIS software was used to evaluate the spatial distribution of the generated domestic waste and ultimately multiple regression analysis was used to evaluate the factors affecting the generation of domestic waste. The results of this study showed that the average waste generated by each person was 0.588 kilograms per day. with the share of organic waste generated by each person being 0.409 kilograms per day and the share of solid waste generated by each person being 0.179 kilograms per day. The results from spatial distribution of waste generation showed a certain pattern in three groups and a higher rate of waste generation in the northern and northwestern parts, especially in the subdistrict. The results of multiple regression analysis showed that the households’ income, assets, age, and personal attitude are respectively the most important variables affecting waste generation. The housholds’ attitude and indigenous knowledge on efficient use of materials are also the key factors which can help reducing waste generation.

  13. An integrated transcriptomics-guided genome-wide promoter analysis and next-generation proteomics approach to mine factor(s) regulating cellular differentiation

    Science.gov (United States)

    Mandal, Kamal; Bader, Samuel L.; Kumar, Pankaj; Malakar, Dipankar; Campbell, David S.; Pradhan, Bhola Shankar; Sarkar, Rajesh K.; Wadhwa, Neerja; Sensharma, Souvik; Jain, Vaibhav; Moritz, Robert L.

    2017-01-01

    Abstract Differential next-generation-omics approaches aid in the visualization of biological processes and pave the way for divulging important events and/or interactions leading to a functional output at cellular or systems level. To this end, we undertook an integrated Nextgen transcriptomics and proteomics approach to divulge differential gene expression of infant and pubertal rat Sertoli cells (Sc).Unlike, pubertal Sc, infant Sc are immature and fail to support spermatogenesis. We found exclusive association of 14 and 19 transcription factor binding sites to infantile and pubertal states of Sc, respectively, using differential transcriptomics-guided genome-wide computational analysis of relevant promoters employing 220 Positional Weight Matrices from the TRANSFAC database. Proteomic SWATH-MS analysis provided extensive quantification of nuclear and cytoplasmic protein fractions revealing 1,670 proteins differentially located between the nucleus and cytoplasm of infant Sc and 890 proteins differentially located within those of pubertal Sc. Based on our multi-omics approach, the transcription factor YY1 was identified as one of the lead candidates regulating differentiation of Sc.YY1 was found to have abundant binding sites on promoters of genes upregulated during puberty. To determine its significance, we generated transgenic rats with Sc specific knockdown of YY1 that led to compromised spermatogenesis. PMID:28065881

  14. Analysis of generation factors for tectonic deformation in the Xigeda formation in southwestern China%Analysis of generation factors for tectonic deformation in the Xigeda formation in southwestern China

    Institute of Scientific and Technical Information of China (English)

    Li Ping; Liu Xingsong; Yang Mei'e; Yuan Jingli

    2012-01-01

    The Xigeda formation is a set of interbreds comprised of half-consolidated silt, fine sand and clay with clear lamination and total thickness of 300 m. It is dated to be the early Pleistocene and widespread distributed on the Quaternary planes of denudation and leveling. This formation has particular tectonic deformation as expressed by deformed belts confined to certain locations, which extend linearly over long distances. It also manifests itself as graben and horst sequences where fault planes are very straight. Various deformation styles, such as horizontal, vertical and oblique dislocations, normal, reverse and thrust faulting resulted in tilts of small blocks in different directions. The clay beds are intruded by underlying sand layers. Parallel ridges and depressions characterize the landscape. These phenomena of deformation are probably the result of intensive vibration Of soil bodies during major earthquakes which caused instantaneous shear, compression and extension. The analysis of generation factors for such tectonic deformation provides a new approach for determination of areas with seismic risks, assessment of earthquake intensity and research of earthquake mechanisms.

  15. Bayesian Exploratory Factor Analysis

    DEFF Research Database (Denmark)

    Conti, Gabriella; Frühwirth-Schnatter, Sylvia; Heckman, James J.;

    2014-01-01

    This paper develops and applies a Bayesian approach to Exploratory Factor Analysis that improves on ad hoc classical approaches. Our framework relies on dedicated factor models and simultaneously determines the number of factors, the allocation of each measurement to a unique factor, and the corr......This paper develops and applies a Bayesian approach to Exploratory Factor Analysis that improves on ad hoc classical approaches. Our framework relies on dedicated factor models and simultaneously determines the number of factors, the allocation of each measurement to a unique factor......, and the corresponding factor loadings. Classical identification criteria are applied and integrated into our Bayesian procedure to generate models that are stable and clearly interpretable. A Monte Carlo study confirms the validity of the approach. The method is used to produce interpretable low dimensional aggregates...

  16. Bayesian Exploratory Factor Analysis

    DEFF Research Database (Denmark)

    Conti, Gabriella; Frühwirth-Schnatter, Sylvia; Heckman, James J.

    2014-01-01

    This paper develops and applies a Bayesian approach to Exploratory Factor Analysis that improves on ad hoc classical approaches. Our framework relies on dedicated factor models and simultaneously determines the number of factors, the allocation of each measurement to a unique factor......, and the corresponding factor loadings. Classical identification criteria are applied and integrated into our Bayesian procedure to generate models that are stable and clearly interpretable. A Monte Carlo study confirms the validity of the approach. The method is used to produce interpretable low dimensional aggregates...

  17. Benefit Evaluation of Wind Turbine Generators in Wind Farms Using Capacity-Factor Analysis and Economic-Cost Methods

    DEFF Research Database (Denmark)

    Chen, Zhe; Wang, L.; Yeh, T-H.

    2009-01-01

    Due to the recent price spike of the international oil and the concern of global warming, the development and deployment of renewable energy become one of the most important energy policies around the globe. Currently, there are different capacities and hub heights for commercial wind turbine...... generators (WTGs). To fully capture wind energy, different wind farms (WFs) should select adequate capacity of WTGs to effectively harvest wind energy and maximize their economic benefit. To establish selection criterion, this paper first derives the equations for capacity factor (CF) and pairing performance...

  18. The New Generation Cultural Analysis of Influence Factors to Migrant Workers%新生代农民工文化适应影响因素分析

    Institute of Scientific and Technical Information of China (English)

    邹显林

    2012-01-01

    从个人的发展愿景、自身的适应能力、现实的情感氛围及外部的环境因素等四大方面分析新生代农民工文化适应的影响因素,以帮助新生代农民工尽快融入城市,顺利融入社会。%In this paper, the new generation of their cultural adapt to the factors affecting the thorough analysis, mainly including the development of personal vision, their ability to adapt to the emotional atmosphere, reality and external environment factors four aspects, in order to help rural migrant workers in cities as soon as possible the new generation, smoothly into society.

  19. Foundations of factor analysis

    CERN Document Server

    Mulaik, Stanley A

    2009-01-01

    Introduction Factor Analysis and Structural Theories Brief History of Factor Analysis as a Linear Model Example of Factor AnalysisMathematical Foundations for Factor Analysis Introduction Scalar AlgebraVectorsMatrix AlgebraDeterminants Treatment of Variables as Vectors Maxima and Minima of FunctionsComposite Variables and Linear Transformations Introduction Composite Variables Unweighted Composite VariablesDifferentially Weighted Composites Matrix EquationsMulti

  20. Factor Analysis of the ESL/EFL Strategy Inventory for Language Learning: Generation 1.5 Korean Immigrant College Students' Language Learning Strategies

    Science.gov (United States)

    Heo, Misook; Stoffa, Rosa; Kush, Joseph C.

    2012-01-01

    This study explores factors related to the language learning strategies of second language learners, specifically Generation 1.5 Korean immigrant students--the seventh-largest and one of the fastest growing foreign-born groups in the USA. Participants in this study were members of the Korean communities located in Pittsburgh and Philadelphia who…

  1. Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation.

    Directory of Open Access Journals (Sweden)

    Kathleen E Brummel-Ziedins

    Full Text Available Factor (fXa is a critical enzyme in blood coagulation that is responsible for the initiation and propagation of thrombin generation. Previously we have shown that analysis of computationally generated thrombin profiles is a tool to investigate hemostasis in various populations. In this study, we evaluate the potential of computationally derived time courses of fXa generation as another approach for investigating thrombotic risk. Utilizing the case (n = 473 and control (n = 426 population from the Leiden Thrombophilia Study and each individual's plasma protein factor composition for fII, fV, fVII, fVIII, fIX, fX, antithrombin and tissue factor pathway inhibitor, tissue factor-initiated total active fXa generation was assessed using a mathematical model. FXa generation was evaluated by the area under the curve (AUC, the maximum rate (MaxR and level (MaxL and the time to reach these, TMaxR and TMaxL, respectively. FXa generation was analyzed in the entire populations and in defined subgroups (by sex, age, body mass index, oral contraceptive use. The maximum rates and levels of fXa generation occur over a 10- to 12- fold range in both cases and controls. This variation is larger than that observed with thrombin (3-6 fold in the same population. The greatest risk association was obtained using either MaxR or MaxL of fXa generation; with an ∼2.2 fold increased risk for individuals exceeding the 90(th percentile. This risk was similar to that of thrombin generation(MaxR OR 2.6. Grouping defined by oral contraceptive (OC use in the control population showed the biggest differences in fXa generation; a >60% increase in the MaxR upon OC use. FXa generation can distinguish between a subset of individuals characterized by overlapping thrombin generation profiles. Analysis of fXa generation is a phenotypic characteristic which may prove to be a more sensitive discriminator than thrombin generation among all individuals.

  2. Factor Analysis and AIC.

    Science.gov (United States)

    Akaike, Hirotugu

    1987-01-01

    The Akaike Information Criterion (AIC) was introduced to extend the method of maximum likelihood to the multimodel situation. Use of the AIC in factor analysis is interesting when it is viewed as the choice of a Bayesian model; thus, wider applications of AIC are possible. (Author/GDC)

  3. Analysis on Operation Reliability of Generating Units in 2009

    Institute of Scientific and Technical Information of China (English)

    Zhou

    2010-01-01

    This paper presents the data on operation reliability indices and relevant analyses toward China's conventional power generating units in 2009. The units brought into the statistical analysis include 100-MW or above thermal generating units, 40-MW or above hydro generating units, and all nuclear generating units. The reliability indices embodied include utilization hours, times and hours of scheduled outages, times and hours of unscheduled outages, equivalent forced outage rate and equivalent availability factor.

  4. Efficient generation of pronunciation dictionaries: human factors factors during bootstrapping

    CSIR Research Space (South Africa)

    Davel, MH

    2004-10-01

    Full Text Available Bootstrapping techniques have significant potential for the efficient generation of linguistic resources such as electronic pronunciation dictionaries. The authors describe a system and an approach to bootstrapping for the development...

  5. Language Impairment and Generative Analysis

    Directory of Open Access Journals (Sweden)

    Andrej Stopar

    2004-12-01

    Full Text Available This article deals with different types of language impairment from the perspective of generative grammar. The paper focuses on syntactic deficiencies observed in aphasic and SLI (specific language impairment patients. We show that the observed ungrammatical structures do not appear in a random fashion but can be predicted by that theory of universal sentence structure which posits a strict hierarchy of its constituent parts. The article shows that while the hierarchically lower elements remain unaffected, the higher positions in the hierarchy show various degrees of syntactic impairment. The paper supports the implementation of recent developments in the field of generative grammar with the intention of encouraging further theoretical, experimental and therapeutic research in the field.

  6. Longevity of implantable cardioverter-defibrillators for cardiac resynchronization therapy in current clinical practice: an analysis according to influencing factors, device generation, and manufacturer.

    Science.gov (United States)

    Landolina, Maurizio; Curnis, Antonio; Morani, Giovanni; Vado, Antonello; Ammendola, Ernesto; D'onofrio, Antonio; Stabile, Giuseppe; Crosato, Martino; Petracci, Barbara; Ceriotti, Carlo; Bontempi, Luca; Morosato, Martina; Ballari, Gian Paolo; Gasparini, Maurizio

    2015-08-01

    Device replacement at the time of battery depletion of implantable cardioverter-defibrillators (ICDs) may carry a considerable risk of complications and engenders costs for healthcare systems. Therefore, ICD device longevity is extremely important both from a clinical and economic standpoint. Cardiac resynchronization therapy defibrillators (CRT-D) battery longevity is shorter than ICDs. We determined the rate of replacements for battery depletion and we identified possible determinants of early depletion in a series of patients who had undergone implantation of CRT-D devices. We retrieved data on 1726 consecutive CRT-D systems implanted from January 2008 to March 2010 in nine centres. Five years after a successful CRT-D implantation procedure, 46% of devices were replaced due to battery depletion. The time to device replacement for battery depletion differed considerably among currently available CRT-D systems from different manufacturers, with rates of batteries still in service at 5 years ranging from 52 to 88% (log-rank test, P < 0.001). Left ventricular lead output and unipolar pacing configuration were independent determinants of early depletion [hazard ratio (HR): 1.96; 95% 95% confidence interval (CI): 1.57-2.46; P < 0.001 and HR: 1.58, 95% CI: 1.25-2.01; P < 0.001, respectively]. The implantation of a recent-generation device (HR: 0.57; 95% CI: 0.45-0.72; P < 0.001), the battery chemistry and the CRT-D manufacturer (HR: 0.64; 95% CI: 0.47-0.89; P = 0.008) were additional factors associated with replacement for battery depletion. The device longevity at 5 years was 54%. High left ventricular lead output and unipolar pacing configuration were associated with early battery depletion, while recent-generation CRT-Ds displayed better longevity. Significant differences emerged among currently available CRT-D systems from different manufacturers. © The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology.

  7. Human reliability, error, and human factors in power generation

    CERN Document Server

    Dhillon, B S

    2014-01-01

    Human reliability, error, and human factors in the area of power generation have been receiving increasing attention in recent years. Each year billions of dollars are spent in the area of power generation to design, construct/manufacture, operate, and maintain various types of power systems around the globe, and such systems often fail due to human error. This book compiles various recent results and data into one volume, and eliminates the need to consult many diverse sources to obtain vital information.  It enables potential readers to delve deeper into a specific area, providing the source of most of the material presented in references at the end of each chapter. Examples along with solutions are also provided at appropriate places, and there are numerous problems for testing the reader’s comprehension.  Chapters cover a broad range of topics, including general methods for performing human reliability and error analysis in power plants, specific human reliability analysis methods for nuclear power pl...

  8. Java Physics Generator and Analysis Modules

    CERN Document Server

    Ronan, Michael T

    2003-01-01

    A Java software framework allows modules written in different languages to be used in a high level Object-Oriented (OO) environment. Java Native Interfaces (JNI) for Linear Collider (LC) physics event generators are used in defining a common generator interface package. Portable-JNI for TESLA and Asian JLC detector simulation modules have been written for performing comparisons to the American LC detector simulation. Physics and detector Java analysis modules using prototype HEP class libraries provide high level OO study tools. Complete physics generation, parallel detector simulations and event analysis for full 500 fb$^{-1}$ simulated data samples are performed in single-pass batch jobs. Java histogram objects files are saved for final presentation using the Java Analysis Studio (JAS). The software architecture, JNI designs and overall performance is presented. Comparisons of American, Asian and European detector simulations of Higgsstrahlung events generated by Pandora, Pythia and Whizard are made.

  9. The Three Generations of Flow Injection Analysis

    DEFF Research Database (Denmark)

    Hansen, Elo Harald; Wang, Jianhua

    2004-01-01

    The characteristics of the three generations of flow injection analysis, that is, FIA, sequential injection analysis (SIA), and bead injection-lab-on-valve (BI-LOV), are briefly outlined, their individual advantages and shortcomings are discussed, and selected practical applications are presented....

  10. Next-Generation Bioacoustic Analysis Software

    Science.gov (United States)

    2015-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Next- Generation Bioacoustic Analysis Software David K...estimates are in one dimension (bearing), two (X-Y position), or three (X-Y- Z position), analysis software is necessary. Marine mammal acoustic data is

  11. Factor analysis of multivariate data

    Digital Repository Service at National Institute of Oceanography (India)

    Fernandes, A.A.; Mahadevan, R.

    A brief introduction to factor analysis is presented. A FORTRAN program, which can perform the Q-mode and R-mode factor analysis and the singular value decomposition of a given data matrix is presented in Appendix B. This computer program, uses...

  12. Factor Analysis of Intern Effectiveness

    Science.gov (United States)

    Womack, Sid T.; Hannah, Shellie Louise; Bell, Columbus David

    2012-01-01

    Four factors in teaching intern effectiveness, as measured by a Praxis III-similar instrument, were found among observational data of teaching interns during the 2010 spring semester. Those factors were lesson planning, teacher/student reflection, fairness & safe environment, and professionalism/efficacy. This factor analysis was as much of a…

  13. Factor analysis and missing data

    NARCIS (Netherlands)

    Kamakura, WA; Wedel, M

    2000-01-01

    The authors study the estimation of factor models and the imputation of missing data and propose an approach that provides direct estimates of factor weights without the replacement of missing data with imputed values. First, the approach is useful in applications of factor analysis in the presence

  14. Generation interval contraction and epidemic data analysis

    CERN Document Server

    Kenah, Eben; Robins, James M

    2008-01-01

    The generation interval is the time between the infection time of an infected person and the infection time of his or her infector. Probability density functions for generation intervals have been an important input for epidemic models and epidemic data analysis. In this paper, we specify a general stochastic SIR epidemic model and prove that the mean generation interval decreases when susceptible persons are at risk of infectious contact from multiple sources. The intuition behind this is that when a susceptible person has multiple potential infectors, there is a ``race'' to infect him or her in which only the first infectious contact leads to infection. In an epidemic, the mean generation interval contracts as the prevalence of infection increases. We call this global competition among potential infectors. When there is rapid transmission within clusters of contacts, generation interval contraction can be caused by a high local prevalence of infection even when the global prevalence is low. We call this loc...

  15. Entropy Generation Analysis of Desalination Technologies

    Directory of Open Access Journals (Sweden)

    John H. Lienhard V

    2011-09-01

    Full Text Available Increasing global demand for fresh water is driving the development and implementation of a wide variety of seawater desalination technologies. Entropy generation analysis, and specifically, Second Law efficiency, is an important tool for illustrating the influence of irreversibilities within a system on the required energy input. When defining Second Law efficiency, the useful exergy output of the system must be properly defined. For desalination systems, this is the minimum least work of separation required to extract a unit of water from a feed stream of a given salinity. In order to evaluate the Second Law efficiency, entropy generation mechanisms present in a wide range of desalination processes are analyzed. In particular, entropy generated in the run down to equilibrium of discharge streams must be considered. Physical models are applied to estimate the magnitude of entropy generation by component and individual processes. These formulations are applied to calculate the total entropy generation in several desalination systems including multiple effect distillation, multistage flash, membrane distillation, mechanical vapor compression, reverse osmosis, and humidification-dehumidification. Within each technology, the relative importance of each source of entropy generation is discussed in order to determine which should be the target of entropy generation minimization. As given here, the correct application of Second Law efficiency shows which systems operate closest to the reversible limit and helps to indicate which systems have the greatest potential for improvement.

  16. Manual for wave generation and analysis

    DEFF Research Database (Denmark)

    Jakobsen, Morten Møller

    This Manual is for the included wave generation and analysis software and graphical user interface. The package is made for Matlab and is meant for educational purposes. The code is free to use under the GNU Public License (GPL). It is still in development and should be considered as such. If you...

  17. Empirical Analysis of the Employment Demand Priority of New Generation Migrant Workers and Its Influencing Factors%新生代农民工择业需求优先序及其差异

    Institute of Scientific and Technical Information of China (English)

    彭安明; 朱红根; 康兰媛

    2014-01-01

    基于549份新生代农民工数据,运用聚类分析法对新生代农民工择业需求优先序进行考察,分析新生代农民工择业需求的影响因素,研究结果表明:第一,新生代农民工择业最关注工资收入情况,其次对个人发展、医疗保险、工作环境和权益保护的需求也较大;第二,新生代农民工择业需求影响因素的分析表明,不同个体特征的新生代农民工的择业需求存在差异,不同区域、不同企业新生代农民工的择业需求也存在差异。%Based on 549 copies of survey data made on the new generation of migrant workers,this paper firstly analyzes the employment demand priority of the new generation migrant workers by using cluster analysis and then analyses its influencing factors.Results show that new generation migrant workers pay most attention on wage income,and it is followed by personal development,medical insurance,working environment and rights protection.The analyzing results show that different characteristics of individual new generation migrant worker may have different employment demand.Migrant workers from different regions and different enterprises also have different demand on distinct working conditions.

  18. Analysis of Linear MHD Power Generators

    Energy Technology Data Exchange (ETDEWEB)

    Witalis, E.A.

    1965-02-15

    The finite electrode size effects on the performance of an infinitely long MHD power generation duct are calculated by means of conformal mapping. The general conformal transformation is deduced and applied in a graphic way. The analysis includes variations in the segmentation degree, the Hall parameter of the gas and the electrode/insulator length ratio as well as the influence of the external circuitry and loading. A general criterion for a minimum of the generator internal resistance is given. The same criterion gives the conditions for the occurrence of internal current leakage between adjacent electrodes. It is also shown that the highest power output at a prescribed efficiency is always obtained when the current is made to flow between exactly opposed electrodes. Curves are presented showing the power-efficiency relations and other generator properties as depending on the segmentation degree and the Hall parameter in the cases of axial and transverse power extraction. The implications of limiting the current to flow between a finite number of identical electrodes are introduced and combined with the condition for current flow between opposed electrodes. The characteristics of generators with one or a few external loads can then be determined completely and examples are given in a table. It is shown that the performance of such generators must not necessarily be inferior to that of segmented generators with many independent loads. However, the problems of channel end losses and off-design loading have not been taken into consideration.

  19. First course in factor analysis

    CERN Document Server

    Comrey, Andrew L

    2013-01-01

    The goal of this book is to foster a basic understanding of factor analytic techniques so that readers can use them in their own research and critically evaluate their use by other researchers. Both the underlying theory and correct application are emphasized. The theory is presented through the mathematical basis of the most common factor analytic models and several methods used in factor analysis. On the application side, considerable attention is given to the extraction problem, the rotation problem, and the interpretation of factor analytic results. Hence, readers are given a background of

  20. Vogtle Electric Generating Plant ETE Analysis Review

    Energy Technology Data Exchange (ETDEWEB)

    Diediker, Nona H.; Jones, Joe A.

    2006-12-09

    Under contract with the Nuclear Regulatory Commission (NRC), staff from Pacific Northwest National Laboratory (PNNL) and Sandia National Laboratory (SNL)-Albuquerque reviewed the evacuation time estimate (ETE) analysis dated April 2006 prepared by IEM for the Vogtle Electric Generating Plant (VEGP). The ETE analysis was reviewed for consistency with federal regulations using the NRC guidelines in Review Standard (RS)-002, Supplement 2 and Appendix 4 to NUREG-0654, and NUREG/CR-4831. Additional sources of information referenced in the analysis and used in the review included NUREG/CR-6863 and NUREG/CR-6864. The PNNL report includes general comments, data needs or clarifications, and requests for additional information (RAI) resulting from review of the ETE analysis.

  1. Finite Time Analysis of a Tri-Generation Cycle

    Directory of Open Access Journals (Sweden)

    Brian Agnew

    2015-06-01

    Full Text Available A review of the literature indicates that current tri-generation cycles show low thermal performance, even when optimised for maximum useful output. This paper presents a Finite Time analysis of a tri-generation cycle that is based upon coupled power and refrigeration Carnot cycles. The analysis applies equally well to Stirling cycles or any cycle that exhibits isothermal heat transfer with the environment and is internally reversible. It is shown that it is possible to obtain a significantly higher energy utilisation factor with this type of cycle by considering the energy transferred during the isothermal compression and expansion processes as useful products thus making the energy utilisation larger than the enthalpy drop of the working fluid of the power cycle. The cycle is shown to have the highest energy utilisation factor when energy is supplied from a low temperature heat source and in this case the output is biased towards heating and cooling.

  2. Statistical analysis of next generation sequencing data

    CERN Document Server

    Nettleton, Dan

    2014-01-01

    Next Generation Sequencing (NGS) is the latest high throughput technology to revolutionize genomic research. NGS generates massive genomic datasets that play a key role in the big data phenomenon that surrounds us today. To extract signals from high-dimensional NGS data and make valid statistical inferences and predictions, novel data analytic and statistical techniques are needed. This book contains 20 chapters written by prominent statisticians working with NGS data. The topics range from basic preprocessing and analysis with NGS data to more complex genomic applications such as copy number variation and isoform expression detection. Research statisticians who want to learn about this growing and exciting area will find this book useful. In addition, many chapters from this book could be included in graduate-level classes in statistical bioinformatics for training future biostatisticians who will be expected to deal with genomic data in basic biomedical research, genomic clinical trials and personalized med...

  3. ANGSD: Analysis of Next Generation Sequencing Data.

    Science.gov (United States)

    Korneliussen, Thorfinn Sand; Albrechtsen, Anders; Nielsen, Rasmus

    2014-11-25

    High-throughput DNA sequencing technologies are generating vast amounts of data. Fast, flexible and memory efficient implementations are needed in order to facilitate analyses of thousands of samples simultaneously. We present a multithreaded program suite called ANGSD. This program can calculate various summary statistics, and perform association mapping and population genetic analyses utilizing the full information in next generation sequencing data by working directly on the raw sequencing data or by using genotype likelihoods. The open source c/c++ program ANGSD is available at http://www.popgen.dk/angsd . The program is tested and validated on GNU/Linux systems. The program facilitates multiple input formats including BAM and imputed beagle genotype probability files. The program allow the user to choose between combinations of existing methods and can perform analysis that is not implemented elsewhere.

  4. Transforming Rubrics Using Factor Analysis

    Science.gov (United States)

    Baryla, Ed; Shelley, Gary; Trainor, William

    2012-01-01

    Student learning and program effectiveness is often assessed using rubrics. While much time and effort may go into their creation, it is equally important to assess how effective and efficient the rubrics actually are in terms of measuring competencies over a number of criteria. This study demonstrates the use of common factor analysis to identify…

  5. Thermal generating plant (100 MW+) availability and unavailability factors 1995

    Energy Technology Data Exchange (ETDEWEB)

    Glorian, D.; Spiegelberg-Planer, R.

    1995-12-31

    This paper was presented at Working Group Session 8: Performance of thermal generating plant. Results are presented of a survey undertaken every three years on the availability and unavailability of both fossil fired and nuclear power plants world-wide. For fossil-fuel thermal generating units data is presented by eight unit sizes and three classes of fuel, and for nuclear thermal generating units data is presented by type of reactor. Analysis is presented of the overall performance of both types of unit. For fossil-fuel units the lesson learnt through this survey covering 40 countries are consistent with those presented in the 1992 report. For the period 1991-1993 they reveal a further 1.9% improvement in plant availability. This improvement is almost solely due to a reduction in unplanned availability. This clearly demonstrates the better usage of planned outages and improved preventive maintenance practices. 4 refs., 29 figs., 40 tabs.

  6. Identification of noise in linear data sets by factor analysis

    Energy Technology Data Exchange (ETDEWEB)

    Roscoe, B.A.; Hopke, Ph.K. (Illinois Univ., Urbana (USA))

    1982-01-01

    A technique which has the ability to identify bad data points, after the data has been generated, is classical factor analysis. The ability of classical factor analysis to identify two different types of data errors make it ideally suited for scanning large data sets. Since the results yielded by factor analysis indicate correlations between parameters, one must know something about the nature of the data set and the analytical techniques used to obtain it to confidentially isolate errors.

  7. Generational Approach to Factors Influencing Career Choice in Accounting

    Directory of Open Access Journals (Sweden)

    Jony Hsiao

    Full Text Available ABSTRACT This research aims to grasp which factors influence the generation Y to choose accounting as its career. A significant decline in the number of candidates willing to pursue a career as accountant has been observed abroad - USA, Australia, and Japan. However, in other countries - Brazil, Singapore, and Hong Kong - the opposite has been observed. Another issue is the decline in educational qualification of those pursuing an accounting career, contributing in a way that many talented students change their career choice. This may be explained by the fact that people tend to believe accounting is an exact science, full of calculations, boring, and not very creative, bringing an unbalance between the traits an individual should have according to the job market and those perceived by society. In order to give a contribution to literature concerning the factors that influence the generation Y in its career choice, a goal of this research was conducting an exploratory study where some hypotheses were formulated to support the discussion. We used Mannheim's Generational Theory and the literature on career choice. Data collection was carried out using a questionnaire, based on Schwartz's Portrait Value Questionnaire and Germeijs and Verschueren's Student Choice Task Inventory, adapted through focus group interview. Data were fully collected online and the sample consisted of 665 subjects. The results showed that people who chose accounting as their career were influenced by factors such as creativity, independence, challenging and dynamic environment, job security, money-making, job availability, and other significant people - friends and teachers. The subjects were not influenced by social factors, such as working with people and making contributions to society and family. They wish for more autonomy, creativity, and flexibility at work, and people still care about job security and money-making.

  8. Data analysis for steam generator tubing samples

    Energy Technology Data Exchange (ETDEWEB)

    Dodd, C.V.

    1996-07-01

    The objective of the Improved Eddy-Current ISI for Steam Generators program is to upgrade and validate eddy-current inspections, including probes, instrumentation, and data processing techniques for inservice inspection of new, used, and repaired steam generator tubes; to improve defect detection, classification and characterization as affected by diameter and thickness variations, denting, probe wobble, tube sheet, tube supports, copper and sludge deposits, even when defect types and other variables occur in combination; to transfer this advanced technology to NRC`s mobile NDE laboratory and staff. This report provides a description of the application of advanced eddy-current neural network analysis methods for the detection and evaluation of common steam generator tubing flaws including axial and circumferential outer-diameter stress-corrosion cracking and intergranular attack. The report describes the training of the neural networks on tubing samples with known defects and the subsequent evaluation results for unknown samples. Evaluations were done in the presence of artifacts. Computer programs are given in the appendix.

  9. Stochastic Modeling and Analysis of Power System with Renewable Generation

    DEFF Research Database (Denmark)

    Chen, Peiyuan

    to evaluate year-to-year variation of wind power generation through a sensitivity analysis and to forecast very short-term wind power through a model-based prediction method. The stochastic load model is established on the basis of a seasonal autoregressive moving average (ARMA) process. It is demonstrated...... that such a stochastic model can be used to simulate the effect of load management on the load duration curve. As CHP units are turned on and off by regulating power, CHP generation has discrete output and thus can be modeled by a transition matrix based discrete Markov chain. As the CHP generation has a strong diurnal...... that minimizes the expectation of power losses of a 69-bus distribution system by controlling the power factor of WTs. The optimization is subjected to the probabilistic constraints of bus voltage and line current. The algorithm combines a constrained nonlinear optimization algorithm and a Monte Carlo based PLF...

  10. Performance analysis and experimental study on Flat Optical Comb Generation

    Directory of Open Access Journals (Sweden)

    Haining Li

    2013-01-01

    Full Text Available The performance of the optical frequency comb generation based on the re-circulating frequency shifter has been analyzed and demonstrated in this paper. We have theoretically analyzed the condition for flatness of the optical frequency comb and the relative intensity noise influence. We find out the influence to the flatness of optical comb owing to amplifier relative intensity noise and modulator relative factors imperfect, such as input RF signals amplitude and phase deviation and modulator defect owing to manufacture for the first time. Moreover, to verify the theoretical analysis, a 16 comb lines and spacing 12.5 GHz RFS generation system have also been carried out, and the results are in good agreement with the theoretical analysis results.

  11. Coal analysis using the pulsed neutron generator

    Institute of Scientific and Technical Information of China (English)

    JING Shi-Wei; CHI Yan-Tao; ZHAO Xin-Hui; LIU Lin-Mao; GU De-Shan; QIAO Shuang; SANG Hai-Feng; ZHANG Yong-Xiang; ZHANG Zhong-Hua; CAO Xi-Zheng; TIAN Yu-Bing

    2003-01-01

    A prototype of elemental analyzer for coal has been developed by using a PFTNA (pulse fast thermalneutron analysis) system. The PFTNA technology is based on the reactions such as (n, γ), (n, n'γ), (n, Pγ), etc. byexamining the characteristic gamma rays emitted. In our prototype a pulsed neutron generator provides 14 MeV pulseneutrons, which contribute to the separation of spectrum Ⅱ (the sum of capture and activation spectrum) fiom spec-trum Ⅰ (the sum of inelastic, capture and activation spectrum), and thus to the measurement of C and O contents incoal. Data management is completed by computer program using the least-square regression method. The experimentin Changshan Power Plant for 3 months showed that the precision of calorific value, whole water, volatile content andash content is 0.5 k J/kg, 1.0 wt%, 2.0 wt% and 1.5 wt%, respectively.

  12. Prognostic Analysis of the Tactical Quiet Generator

    Energy Technology Data Exchange (ETDEWEB)

    Hively, Lee M [ORNL

    2008-09-01

    The U.S. Army needs prognostic analysis of mission-critical equipment to enable condition-based maintenance before failure. ORNL has developed and patented prognostic technology that quantifies condition change from noisy, multi-channel, time-serial data. This report describes an initial application of ORNL's prognostic technology to the Army's Tactical Quiet Generator (TQG), which is designed to operate continuously at 10 kW. Less-than-full power operation causes unburned fuel to accumulate on internal components, thereby degrading operation and eventually leading to failure. The first objective of this work was identification of easily-acquired, process-indicative data. Two types of appropriate data were identified, namely output-electrical current and voltage, plus tri-axial acceleration (vibration). The second objective of this work was data quality analysis to avoid the garbage-in-garbage-out syndrome. Quality analysis identified more than 10% of the current data as having consecutive values that are constant, or that saturate at an extreme value. Consequently, the electrical data were not analyzed further. The third objective was condition-change analysis to indicate operational stress under non-ideal operation and machine degradation in proportion to the operational stress. Application of ORNL's novel phase-space dissimilarity measures to the vibration power quantified the rising operational stress in direct proportion to the less-than-full-load power. We conclude that ORNL's technology is an excellent candidate to meet the U.S. Army's need for equipment prognostication.

  13. A kernel version of spatial factor analysis

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg

    2009-01-01

    of PCA and related techniques. An interesting dilemma in reduction of dimensionality of data is the desire to obtain simplicity for better understanding, visualization and interpretation of the data on the one hand, and the desire to retain sufficient detail for adequate representation on the other hand......Based on work by Pearson in 1901, Hotelling in 1933 introduced principal component analysis (PCA). PCA is often used for general feature generation and linear orthogonalization or compression by dimensionality reduction of correlated multivariate data, see Jolliffe for a comprehensive description...... version of PCA handles nonlinearities by implicitly transforming data into high (even infinite) dimensional feature space via the kernel function and then performing a linear analysis in that space. In this paper we shall apply kernel versions of PCA, maximum autocorrelation factor (MAF) analysis...

  14. Analysis of hydrocarbons generated in coalbeds

    Science.gov (United States)

    Butala, Steven John M.

    This dissertation describes kinetic calculations using literature data to predict formation rates and product yields of oil and gas at typical low-temperature conditions in coalbeds. These data indicate that gas formation rates from hydrocarbon thermolysis are too low to have generated commercial quantities of natural gas, assuming bulk first-order kinetics. Acid-mineral-catalyzed cracking, transition-metal-catalyzed hydrogenolysis of liquid hydrocarbons, and catalyzed CO2 hydrogenation form gas at high rates. The gaseous product compositions for these reactions are nearly the same as those for typical natural coalbed gases, while those from thermal and catalytic cracking are more representative of atypical coalbed gases. Three Argonne Premium Coals (Upper-Freeport, Pittsburgh #8 and Lewiston-Stockton) were extracted with benzene in both Soxhlet and elevated pressure extraction (EPE) systems. The extracts were compared on the basis of dry mass yield and hydrocarbon profiles obtained by gas chromatography/mass spectrometry. The dry mass yields for the Upper-Freeport coal gave consistent results by both methods, while the yields from the Pittsburgh #8 and Lewiston-Stockton coals were greater by the EPE method. EPE required ˜90 vol. % less solvent compared to Soxhlet extraction. Single-ion-chromatograms of the Soxhlet extracts all exhibited bimodal distributions, while those of the EPE extracts did not. Hydrocarbons analyzed from Greater Green River Basin samples indicate that the natural oils in the basin originated from the coal seams. Analysis of artificially produced oil indicates that hydrous pyrolysis mimics generation of C15+ n-alkanes, but significant variations were found in the branched alkane, low-molecular-weight n-alkanes, and high-molecular-weight aromatic hydrocarbon distributions.

  15. Generating functions for Wilf equivalence under generalized factor order

    CERN Document Server

    Langley, Thomas; Remmel, Jeffrey

    2010-01-01

    Kitaev, Liese, Remmel, and Sagan recently defined generalized factor order on words comprised of letters from a partially ordered set $(P, \\leq_P)$ by setting $u \\leq_P w$ if there is a subword $v$ of $w$ of the same length as $u$ such that the $i$-th character of $v$ is greater than or equal to the $i$-th character of $u$ for all $i$. This subword $v$ is called an embedding of $u$ into $w$. For the case where $P$ is the positive integers with the usual ordering, they defined the weight of a word $w = w_1\\ldots w_n$ to be $\\text{wt}(w) = x^{\\sum_{i=1}^n w_i} t^{n}$, and the corresponding weight generating function $F(u;t,x) = \\sum_{w \\geq_P u} \\text{wt}(w)$. They then defined two words $u$ and $v$ to be Wilf equivalent, denoted $u \\backsim v$, if and only if $F(u;t,x) = F(v;t,x)$. They also defined the related generating function $S(u;t,x) = \\sum_{w \\in \\mathcal{S}(u)} \\text{wt}(w)$ where $\\mathcal{S}(u)$ is the set of all words $w$ such that the only embedding of $u$ into $w$ is a suffix of $w$, and showed t...

  16. Numerical analysis of frictional heat generation in bicycle disc brake

    Science.gov (United States)

    Tahmid, Shadman; Alam, Saima

    2017-06-01

    Precise braking operations are pivotal to ensure safety in modern day vehicle designs. Brakes are mechanical devices for increasing the frictional resistance that obstructs the turning motion of vehicle wheels by absorbing either kinetic, potential energy or both while in action. This absorbed energy appears in the form of heat. Stress, distribution of friction on surface, frictional heat generation, material and geometry are the major controlling factors for efficiency of braking operations. Frictional heat generation and its effective dissipation is one of the most predominant of these factors and hence it is the focus of this study. The purpose of this study is to analyze the thermal behavior of a full bicycle disc brake using finite element method. Sequential thermal structured method based on Ansys 14.5 is used to carry out the numerical simulation for evaluating the variation of total heat flux and temperature profiles with respect to time. The analysis model was studied experimentally and results obtained by numerical analysis were within 3% of the experimental result for maximum temperature. The model is thus adequately validated to be followed for a similar analysis on bicycle brakes.

  17. Performance analysis of piezoelectric bimorph generator

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    In this paper,the theoretical model and simulation of the performance of a piezoelectric (PZT)bimorph generator is introduced.The generator consists of two piezoelectric plates bonded on a substrate metal plate.For an effective electromechanical coupling coefficient (EECC) and the generated energy,the analytical formulae are established with the thickness ratio and the Young's modulus ratio as variables.After giving correlative material parameters,the EECC and generated energy can be computed.The results show that there is a optimal thickness ratio for a piezoelectric bimorph generator to achieve the maximum EECC and electrical energy.The EECC and generated energy decrease with an increase of the Young's modulus ratio.In addition,the influence of mechanical source on electrical energy generation and power output is also considered.

  18. An easy guide to factor analysis

    CERN Document Server

    Kline, Paul

    2014-01-01

    Factor analysis is a statistical technique widely used in psychology and the social sciences. With the advent of powerful computers, factor analysis and other multivariate methods are now available to many more people. An Easy Guide to Factor Analysis presents and explains factor analysis as clearly and simply as possible. The author, Paul Kline, carefully defines all statistical terms and demonstrates step-by-step how to work out a simple example of principal components analysis and rotation. He further explains other methods of factor analysis, including confirmatory and path analysis, a

  19. Parallelization of events generation for data analysis techniques

    CERN Document Server

    Lazzaro, A

    2010-01-01

    With the startup of the LHC experiments at CERN, the involved community is now focusing on the analysis of the collected data. The complexity of the data analyses will be a key factor for finding eventual new phenomena. For such a reason many data analysis tools have been developed in the last several years, which implement several data analysis techniques. Goal of these techniques is the possibility of discriminating events of interest and measuring parameters on a given input sample of events, which are themselves defined by several variables. Also particularly important is the possibility of repeating the determination of the parameters by applying the procedure on several simulated samples, which are generated using Monte Carlo techniques and the knowledge of the probability density functions of the input variables. This procedure achieves a better estimation of the results. Depending on the number of variables, complexity of their probability density functions, number of events, and number of sample to g...

  20. Interdisciplinary Creativity Over Historical Time: A Correlational Analysis of Generational Fluctuations

    Science.gov (United States)

    Simonton, Dean Keith

    1975-01-01

    The interdisciplinary relationships among 15 kinds of creative achievement were examined over 130 generations of European history. A P-technique factor analysis located three major interdisciplinary clusters: (a) discursive; (b) presentational; and (c) rationalism-mysticism. (Author)

  1. Analysis of the Time Influence Factors when Startup of the Emergency Diesel Generator of Nuclear Power Plant%核电厂应急柴油机启动时间影响因素研究

    Institute of Scientific and Technical Information of China (English)

    周国强; 邱毓

    2012-01-01

    When startup of the emergency diesel generator in the nuclear power plant, the ready signal appears indicating the successful startup of the diesel generator and it can be on load at anytime. Based on the safety criteria of the emergency diesel generator for nuclear power plant, the time from the beginning of the start order to the appearance of the ready signal must less than 10 seconds. By dealing with the ready signal problem in Ling'Ao Ⅱ , the time influence factors for the startup of the emergency diesel generator were studied.%核电厂应急柴油机启动完成(Ready)信号的发出表示柴油机启动完成,随时可以带负荷.根据核电厂应急柴油机的安全准则,Ready信号发出时间必须小于10 s.通过对岭澳核电站二期应急柴油机Ready信号时间问题的处理,研究了核电厂应急柴油机启动时间的影响因素.

  2. Analysis of Additive Random Number Generators.

    Science.gov (United States)

    1977-03-01

    linear congruential generators yn*\\* ayn+bmo,iPa- The simplest example of a sequence satisfying (1.1) with *> I is the Fibonacci sequence with p - 2...However, the Fibonacci sequence is not a suitable random number generator because successive triples are very poorly distributed in three...number generator should have small discrepancy. Definition 2.1 can be extended naturally to define discrepancy for sequences of points yn lying in

  3. Studying the factors affecting solar power generation systems performance ( SPGSP

    Directory of Open Access Journals (Sweden)

    Jalal A Al-Tabtabaei

    2014-12-01

    Full Text Available Solar energy is a huge, clean and renewable source of energy. It is also available everywhere on the earth. However, there are many technical and economic difficulties need to be solved so that solar energy becomes a strong competition against the traditional energy sources. Energy from the sun can be used successfully in electric power generation systems. Depending on the climate conditions and the use of a properly designed, installing and maintained system can meet a large demand in this request. Work plane for this research will include many steps, the first step will include an introduction to solar energy. The second step will be a short review of the solar energy availability, geometry, fields of applications and the largest commercial application of solar energy is the solar thermal power generation. In addition, the most common types of solar thermal power plants, the solar field, heat transfer fluid and the power conversion system types will be explained in detail. The third step, a simple analysis for the solar thermal power plant will be explained in order to predict the optimum conditions leading to maximum performance. Discussions of results will be the fourth step. The last step a conclusion and recommendation for future work will also be included.

  4. Piezoelectric Energy Generation from Vehicle Traffic with Technoeconomic Analysis

    Directory of Open Access Journals (Sweden)

    Hiba Najini

    2017-01-01

    Full Text Available This paper presents a technical simulation based system to support the concept of generating energy from road traffic using piezoelectric materials. The simulation based system design replicates a real life system implementation. It investigates practicality and feasibility using a real-time simulation platform known as MATLAB-Simulink. The system design structure was proposed considering factors involved with the field of material sciences for piezoelectric generator modeling and field of power electronics for additional components in producing a realist outcome. It also ensures ease of vehicle performance, as this system utilizes energy source derived as kinetic energy released from vehicles into electrical power output, that is, obtained by harnessing kinetic energy due to strain of vehicles over asphalt road surface. Due to the real-time simulation platform, the system simulation predicts the effective global carbon footprint. In addition to evaluating technical viability, a technoeconomical business analysis provides a strategic perspective. By using the simulation based power generation results, an estimation of implementation cost and payback time in real life (for United Arab Emirates was derived, hence validating and predicting real-time economic outcome. This is followed by a comparative study with other sources of renewable energy based on levelized energy cost factor that justifies the performance of the proposed system over other renewable energy sources, in support of providing an economical solution on reducing global carbon footprint.

  5. High duty factor plasma generator for CERN's Superconducting Proton Linac.

    Science.gov (United States)

    Lettry, J; Kronberger, M; Scrivens, R; Chaudet, E; Faircloth, D; Favre, G; Geisser, J-M; Küchler, D; Mathot, S; Midttun, O; Paoluzzi, M; Schmitzer, C; Steyaert, D

    2010-02-01

    CERN's Linac4 is a 160 MeV linear accelerator currently under construction. It will inject negatively charged hydrogen ions into CERN's PS-Booster. Its ion source is a noncesiated rf driven H(-) volume source directly inspired from the one of DESY and is aimed to deliver pulses of 80 mA of H(-) during 0.4 ms at a 2 Hz repetition rate. The Superconducting Proton Linac (SPL) project is part of the luminosity upgrade of the Large Hadron Collider. It consists of an extension of Linac4 up to 5 GeV and is foreseen to deliver protons to a future 50 GeV synchrotron (PS2). For the SPL high power option (HP-SPL), the ion source would deliver pulses of 80 mA of H(-) during 1.2 ms and operate at a 50 Hz repetition rate. This significant upgrade motivates the design of the new water cooled plasma generator presented in this paper. Its engineering is based on the results of a finite element thermal study of the Linac4 H(-) plasma generator that identified critical components and thermal barriers. A cooling system is proposed which achieves the required heat dissipation and maintains the original functionality. Materials with higher thermal conductivity are selected and, wherever possible, thermal barriers resulting from low pressure contacts are removed by brazing metals on insulators. The AlN plasma chamber cooling circuit is inspired from the approach chosen for the cesiated high duty factor rf H(-) source operating at SNS.

  6. Failure analysis of retired steam generator tubings

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hong Pyo; Kim, J. S.; Hwang, S. S. and others

    2005-04-15

    Degradation of steam generator leads to forced outage and extension of outage, which causes increase in repair cost, cost of purchasing replacement power and radiation exposure of workers. Steam generator tube rupture incident occurred in Uljin 4 in 2002, which made public sensitive to nuclear power plant. To keep nuclear energy as a main energy source, integrity of steam generator should be demonstrated. Quantitative relationship between ECT(eddy current test) signal and crack size is needed in assesment of integrity of steam generator in pressurized water reactor. However, it is not fully established for application in industry. Retired steam generator of Kori 1 has many kinds of crack such as circumferential and axial primary water stress corrosion crack and outer diameter stress corrosion crack(ODSCC). So, it can be used in qualifying and improving ECT technology and in condition monitoring assesment for crack detected in ISI(in service inspection). In addition, examination of pulled tube of Kori 1 retired steam generator will give information about effectiveness of non welded sleeving technology which was employed to repair defect tubes and remedial action which was applied to mitigate ODSCC. In this project, hardware such as semi hot lab. for pulled tube examination and modification transportation cask for pulled tube and software such as procedure of transportation of radioactive steam generator tube and non-destructive and destructive examination of pulled tube were established. Non-destructive and destructive examination of pulled tubes from Kori 1 retired steam generator were performed in semi hot lab. Remedial actions applied to Kori 1 retired steam generator, PWSCC trend and bulk water chemistry and crevice chemistry in Kori 1 were evaluated. Electrochemical decontamination technology for pulled tube was developed to reduce radiation exposure and enhance effectiveness of pulled tube examination. Multiparameter algorithm developed at ANL, USA was

  7. Factor-Group-Generated Polar Spaces and (Multi-)Qudits

    CERN Document Server

    Havlicek, Hans; Saniga, Metod

    2009-01-01

    Recently, a number of interesting relations have been discovered between generalised Pauli/Dirac groups and certain finite geometries. Here, we succeeded in finding a general unifying framework for all these relations. We introduce gradually necessary and sufficient conditions to be met in order to carry out the following programme: Given a group $\\vG$, we first construct vector spaces over $\\GF(p)$, $p$ a prime, by factorising $\\vG$ over appropriate normal subgroups. Then, by expressing $\\GF(p)$ in terms of the commutator subgroup of $\\vG$, we construct alternating bilinear forms, which reflect whether or not two elements of $\\vG$ commute. Restricting to $p=2$, we search for "refinements" in terms of quadratic forms, which capture the fact whether or not the order of an element of $\\vG$ is $\\leq 2$. Such factor-group-generated vector spaces admit a natural reinterpretation in the language of symplectic and orthogonal polar spaces, where each point becomes a "condensation" of several distinct elements of $\\vG...

  8. Human Factors Analysis in Software Engineering

    Institute of Scientific and Technical Information of China (English)

    Xu Ren-zuo; Ma Ruo-feng; Liu Li-na; Xiong Zhong-wei

    2004-01-01

    The general human factors analysis analyzes human functions, effects and influence in a system. But in a narrow sense, it analyzes human influence upon the reliability of a system, it includes traditional human reliability analysis, human error analysis, man-machine interface analysis, human character analysis, and others. A software development project in software engineering is successful or not to be completely determined by human factors. In this paper, we discuss the human factors intensions, declare the importance of human factors analysis for software engineering by listed some instances. At last, we probe preliminarily into the mentality that a practitioner in software engineering should possess.

  9. Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes.

    Science.gov (United States)

    Segers, O; Simioni, P; Tormene, D; Castoldi, E

    2014-03-03

    Carriership of the factor V (FV) Leiden mutation increases the risk of venous thromboembolism (VTE) ~4-fold, but the individual risk of each FV Leiden carrier depends on several co-inherited risk and protective factors. Under the hypothesis that thrombin generation might serve as an intermediate phenotype to identify genetic modulators of VTE risk, we enrolled 188 FV Leiden heterozygotes (11 with VTE) and determined the following parameters: thrombin generation in the absence and presence of activated protein C (APC); plasma levels of prothrombin, factor X, antithrombin, protein S and tissue factor pathway inhibitor; and the genotypes of 24 SNPs located in the genes encoding these coagulation factors and inhibitors. Multiple regression analysis was subsequently applied to identify the (genetic) determinants of thrombin generation. The endogenous thrombin potential (ETP) showed a striking inter-individual variability among different FV Leiden carriers and, especially when measured in the presence of APC, correlated with VTE risk. Several SNPs in the F2 (rs1799963, rs3136516), F10 (rs693335), SERPINC1 (rs2227589), PROS1 (Heerlen polymorphism) and TFPI (rs5940) genes significantly affected the ETP-APC and/or the ETP+APC in FV Leiden carriers. Most of these SNPs have shown an association with VTE risk in conventional epidemiological studies, suggesting that the genetic dissection of thrombin generation leads to the detection of clinically relevant SNPs. In conclusion, we have identified several SNPs that modulate thrombin generation in FV Leiden heterozygotes. These SNPs may help explain the large variability in VTE risk observed among different FV Leiden carriers.

  10. Biodemographic and sociocultural factors in two generations of families from six Polish rural and urban populations.

    Science.gov (United States)

    Wolański, N

    1994-01-01

    There were investigated 6967 families from 6 rural regions, under industrialization, and industrialized urban regions. In the grandparents generation there were taken into account 10 traits (an education level, a mating radius, and a stature) and in parents generation 17 traits (the mentioned-above ones and a number of family members, a flat size, incomes, an employees No., a life mode, smoking etc. Numerical characteristics of traits have been calculated jointly and separately in six populations, matrices of correlation have been constructed and moreover factorial analysis have been carried out, as a result of which 8 rotated factors have been obtained. The highest cultural mobility (increase in the level of education) from generation to generation occurs in the population of textile industry town Lódź. The highest improvement of biological status, the increase in mating radius and high incomes are characteristic for this regions, too. On the other side are villages with low culture mobility (not large increase in education level), slight improvement of biological status, almost no migrations, overcrowded flats and low income per family member. The relations between pairs of traits appear to vary largely in several populations. Generally is a high correlation between the education level of the same family members in both generations. The has been stated negative correlation between grandfather stature both of the mother and the father lines, with occurring of positive assortative mating in the couples of two generations. In both investigated generations there is the positive assortative mating, but the negative correlation in the stature between grandfathers of the mother and the father lines. The grandparents education level is correlated with their and their offsprings stature. The duration of holidays is one of the best (closely correlated with others) indicators of life mode, and partially of a given family living conditions, too. 8 hidden factors have been

  11. A factor analysis to detect factors influencing building national brand

    Directory of Open Access Journals (Sweden)

    Naser Azad

    Full Text Available Developing a national brand is one of the most important issues for development of a brand. In this study, we present factor analysis to detect the most important factors in building a national brand. The proposed study uses factor analysis to extract the most influencing factors and the sample size has been chosen from two major auto makers in Iran called Iran Khodro and Saipa. The questionnaire was designed in Likert scale and distributed among 235 experts. Cronbach alpha is calculated as 84%, which is well above the minimum desirable limit of 0.70. The implementation of factor analysis provides six factors including “cultural image of customers”, “exciting characteristics”, “competitive pricing strategies”, “perception image” and “previous perceptions”.

  12. Analysis of Numerically Generated Wake Structures

    DEFF Research Database (Denmark)

    Ivanell, S.; Sørensen, Jens Nørkær; Mikkelsen, Robert Flemming;

    2009-01-01

    Direct numerical simulations of the Navier-Stokes equations are performed to achieve a better understanding of the behaviour of wakes generated by wind turbines. The simulations are performed by combining the in-house developed computer code EllipSys3D with the actuator-line methodology. In the a......Direct numerical simulations of the Navier-Stokes equations are performed to achieve a better understanding of the behaviour of wakes generated by wind turbines. The simulations are performed by combining the in-house developed computer code EllipSys3D with the actuator-line methodology...

  13. Generator dynamics in aeroelastic analysis and simulations

    DEFF Research Database (Denmark)

    Larsen, Torben J.; Hansen, Morten Hartvig; Iov, F.

    2003-01-01

    This report contains a description of a dynamic model for a doubly-fed induction generator. The model has physical input parameters (voltage, resistance, reactance etc.) and can be used to calculate rotor and stator currents, hence active and reactivepower. A perturbation method has been used...... to reduce the original generator model equations to a set of equations which can be solved with the same time steps as a typical aeroelastic code. The method is used to separate the fast transients of the modelfrom the slow variations and deduce a reduced order expression for the slow part. Dynamic effects...

  14. Generation and analysis of chemical compound libraries

    Energy Technology Data Exchange (ETDEWEB)

    Gregoire, John M.; Jin, Jian; Kan, Kevin S.; Marcin, Martin R.; Mitrovic, Slobodan; Newhouse, Paul F.; Suram, Santosh K.; Xiang, Chengxiang; Zhou, Lan

    2017-10-03

    Various samples are generated on a substrate. The samples each includes or consists of one or more analytes. In some instances, the samples are generated through the use of gels or through vapor deposition techniques. The samples are used in an instrument for screening large numbers of analytes by locating the samples between a working electrode and a counter electrode assembly. The instrument also includes one or more light sources for illuminating each of the samples. The instrument is configured to measure the photocurrent formed through a sample as a result of the illumination of the sample.

  15. Measurement Bias Detection through Factor Analysis

    Science.gov (United States)

    Barendse, M. T.; Oort, F. J.; Werner, C. S.; Ligtvoet, R.; Schermelleh-Engel, K.

    2012-01-01

    Measurement bias is defined as a violation of measurement invariance, which can be investigated through multigroup factor analysis (MGFA), by testing across-group differences in intercepts (uniform bias) and factor loadings (nonuniform bias). Restricted factor analysis (RFA) can also be used to detect measurement bias. To also enable nonuniform…

  16. Data Analysis and Next Generation Assessments

    Science.gov (United States)

    Pon, Kathy

    2013-01-01

    For the last decade, much of the work of California school administrators has been shaped by the accountability of the No Child Left Behind Act. Now as they stand at the precipice of Common Core Standards and next generation assessments, it is important to reflect on the proficiency educators have attained in using data to improve instruction and…

  17. Data Analysis and Next Generation Assessments

    Science.gov (United States)

    Pon, Kathy

    2013-01-01

    For the last decade, much of the work of California school administrators has been shaped by the accountability of the No Child Left Behind Act. Now as they stand at the precipice of Common Core Standards and next generation assessments, it is important to reflect on the proficiency educators have attained in using data to improve instruction and…

  18. Educational Attainment: Analysis by Immigrant Generation. IZA Discussion Paper Series.

    Science.gov (United States)

    Chiswick, Barry R.; DebBurman, Noyna

    This paper presents a theoretical and empirical analysis of the largely ignored issue of the determinants of the educational attainment of adults by immigrant generation. Using Current Population Survey (CPS) data, differences in educational attainment are analyzed by immigrant generation (first, second, and higher order generations), and among…

  19. 新生代农民工失业保险参与意愿及影响因素分析%Analysis of Willingness and Influencing Factors of New -generation Migrant Workers’ Participation in Unemployment Insurance

    Institute of Scientific and Technical Information of China (English)

    凌敏

    2016-01-01

    This paper used Logistic model to statistically analyze the willingness and influencing factors of 521 new-genera-tion migrant workers’ participation in unemployment insurance in Jiangsu area.The results showed that the gender, migrant work-ing period , employment contract, working industry, satisfaction of social insurance policy, and accepted social assistance were the main factors affecting the willingness of migrant workers ’ participation in unemployment insurance .In order to further increase the rate of new-generation migrant workers ’ participation in unemployment insurance , the author put forward the following sugges-tions:improving the social insurance policy , supervising and urging enterprises to sign employment contracts with the migrant workers, and promoting the human capital of new-generation migrant workers.%以521位新生代农民工为例,运用Logistic模型,对其参与失业保险的意愿及影响因素进行了统计分析。研究结果表明:性别、外出务工时间、劳动合同签订情况、所从事的行业、对社会保险政策的满意度以及社会救助接受情况是影响参保意愿的主要因素,需要通过完善社会保险政策、督促企业与农民工签订劳动合同、提升新生代农民工人力资本等方面进一步提高新生代农民工失业保险参与率。

  20. An analysis of the Factors of the Weak Awareness of Political Participation of the New Generation of Migrant Workers%新生代农民工政治参与意识淡薄的成因探析

    Institute of Scientific and Technical Information of China (English)

    张彪

    2011-01-01

    新生代农民工有序的政治参与是其顺利融入城市的重要保障。然而,随着社会转型的加快,新生代农民工的政治参与水平有了很大提高,但受传统政治文化、政治体制、经济因素和自身素质的影响,其政治参与意识还处于比较淡薄的状态。要真正提高新生代农民工的政治参与意识,最根本的就是要加强农民工的公民文化教育、提高政治主体意识和培育公民意识。%The well -organized political participation of the new generation migrant workers is a guar- antee for their integration into the city. With the acceleration of the society transition, the political participa- tion level of the new generation migrant workers is enhanced. However, affected by traditional political cul- ture, political system, economic factors and their own quality, they have a weak awareness of political partici- pation. To improve their political participation awareness, the fundamental way is to strengthen their culture education, enhance their political subject awareness and cultivate their civic awareness.

  1. Harmonic analysis of Doubly Fed Induction Generators

    DEFF Research Database (Denmark)

    Lindholm, Morten; Rasmussen, Tonny Wederberg

    2003-01-01

    This paper gives an overview of the frequency spectrum of the stator and rotor currents in a doubly fed induction generator (DFIG) used in wind power applications. The paper also presents a method to eliminate higher harmonics and interharmonics in the DFIG stator current. The method is implemented...... on a 40 kW laboratory model connected to the utility-grid, where the DFIG is supplied by a back-to-back 3-level NPC-converter....

  2. ANALYSIS OF LEARNER PROFILE GENERATION ALGORITHMS

    OpenAIRE

    ROHINI NAIR; KAVITA KELKAR

    2012-01-01

    With the rapid growth of computer and Internet technologies, e-learning has become a major trend in the computer assisted teaching and learning fields. By observing how learners behave during their online self-study, educators are then capable of comparing, evaluating, and profiling individual learners’ learning processes andthus making suggestions to learners with similar characteristics in the same context. Learner profile generation can be achieved by various methods like sequential data m...

  3. Generating a robust statistical causal structure over 13 cardiovascular disease risk factors using genomics data.

    Science.gov (United States)

    Yazdani, Azam; Yazdani, Akram; Samiei, Ahmad; Boerwinkle, Eric

    2016-04-01

    Understanding causal relationships among large numbers of variables is a fundamental goal of biomedical sciences and can be facilitated by Directed Acyclic Graphs (DAGs) where directed edges between nodes represent the influence of components of the system on each other. In an observational setting, some of the directions are often unidentifiable because of Markov equivalency. Additional exogenous information, such as expert knowledge or genotype data can help establish directionality among the endogenous variables. In this study, we use the method of principle component analysis to extract information across the genome in order to generate a robust statistical causal network among phenotypes, the variables of primary interest. The method is applied to 590,020 SNP genotypes measured on 1596 individuals to generate the statistical causal network of 13 cardiovascular disease risk factor phenotypes. First, principal component analysis was used to capture information across the genome. The principal components were then used to identify a robust causal network structure, GDAG, among the phenotypes. Analyzing a robust causal network over risk factors reveals the flow of information in direct and alternative paths, as well as determining predictors and good targets for intervention. For example, the analysis identified BMI as influencing multiple other risk factor phenotypes and a good target for intervention to lower disease risk.

  4. Model Based Analysis and Test Generation for Flight Software

    Science.gov (United States)

    Pasareanu, Corina S.; Schumann, Johann M.; Mehlitz, Peter C.; Lowry, Mike R.; Karsai, Gabor; Nine, Harmon; Neema, Sandeep

    2009-01-01

    We describe a framework for model-based analysis and test case generation in the context of a heterogeneous model-based development paradigm that uses and combines Math- Works and UML 2.0 models and the associated code generation tools. This paradigm poses novel challenges to analysis and test case generation that, to the best of our knowledge, have not been addressed before. The framework is based on a common intermediate representation for different modeling formalisms and leverages and extends model checking and symbolic execution tools for model analysis and test case generation, respectively. We discuss the application of our framework to software models for a NASA flight mission.

  5. Correspondence factor analysis of steroid libraries.

    Science.gov (United States)

    Ojasoo, T; Raynaud, J P; Doré, J C

    1995-06-01

    The receptor binding of a library of 187 steroids to five steroid hormone receptors (estrogen, progestin, androgen, mineralocorticoid, and glucocorticoid) has been analyzed by correspondence factor analysis (CFA) in order to illustrate how the method could be used to derive structure-activity-relationships from much larger libraries. CFA is a cartographic multivariate technique that provides objective distribution maps of the data after reduction and filtering of redundant information and noise. The key to the analysis of very complex data tables is the formation of barycenters (steroids with one or more common structural fragments) that can be introduced into CFA analyses used as mathematical models. This is possible in CFA because the method uses X2-metrics and is based on the distributional equivalence of the rows and columns of the transformed data matrix. We have thus demonstrated, in purely objective statistical terms, the general conclusions on the specificity of various functional and other groups derived from prior analyses by expert intuition and reasoning. A finer analysis was made of a series of A-ring phenols showing the high degree of glucocorticoid receptor and progesterone receptor binding that can be generated by certain C-11-substitutions despite the presence of the phenolic A-ring characteristic of estrogen receptor-specific binding.

  6. Attitude Exploration Using Factor Analysis Technique

    Directory of Open Access Journals (Sweden)

    Monika Raghuvanshi

    2016-12-01

    Full Text Available Attitude is a psychological variable that contains positive or negative evaluation about people or an environment. The growing generation possesses learning skills, so if positive attitude is inculcated at the right age, it might therefore become habitual. Students in the age group 14-20 years from the city of Bikaner, India, are the target population for this study. An inventory of 30Likert-type scale statements was prepared in order to measure attitude towards the environment and matters related to conservation. The primary data is collected though a structured questionnaire, using cluster sampling technique and analyzed using the IBM SPSS 23 statistical tool. Factor analysis is used to reduce 30 variables to a smaller number of more identifiable groups of variables. Results show that students “need more regulation and voluntary participation to protect the environment”, “need conservation of water and electricity”, “are concerned for undue wastage of water”, “need visible actions to protect the environment”, “need strengthening of the public transport system”, “are a little bit ignorant about the consequences of global warming”, “want prevention of water pollution by industries”, “need changing of personal habits to protect the environment”, and “don’t have firsthand experience of global warming”. Analysis revealed that nine factors obtained could explain about 58.5% variance in the attitude of secondary school students towards the environment in the city of Bikaner, India. The remaining 39.6% variance is attributed to other elements not explained by this analysis. A global campaign for improvement in attitude about environmental issues and its utility in daily lives may boost positive youth attitudes, potentially impacting worldwide. A cross-disciplinary approach may be developed by teaching along with other related disciplines such as science, economics, and social studies etc.

  7. Simulation and template generation for LISA Pathfinder Data Analysis

    Science.gov (United States)

    Rais, Boutheina; Grynagier, Adrien; Diaz-Aguiló, Marc; Armano, Michele

    The LISA PathFinder (LPF) mission is a technology demonstration mission which aims at testing a number of critical technical challenges that the future LISA (Gravitational wave detection in space) mission will face: LPF can be seen as a complex laboratory experiment in space. It is therefore critical to be able to define which measurements and which actuations will be applied during the scientific part of the mission. The LISA Technology Package (LTP), part of ESA's hardware contribution to LPF, outlines hence the importance of developing an appropriate simulation tool in order to test these strate-gies before launch and to analyse the dynamical behaviour of the system during the mission. The detailed model of the simulation can be used in an off-line mode for further planning: cor-rect estimation of timeline priorities, risk factors, duty cycles, data analysis readiness. The Lisa Technology Package Data Analysis (LTPDA) team has developed an object-oriented MATLAB toolbox for general case of data analysis needs. However, to meet specific needs of LPF mis-sion, a template generation tool has been developed. It provides a recognizable data pattern, avoiding the risk of missing the model during mission's analysis. The aim of the template generator tool is to provide tools to analyse LTP system modeled in State Space Model (SSM). The SSM class, the aim of this poster, includes this tools within the LTPDA toolbox. It can be used to generate the time-domain response for any given actuation and/or noise, the frequency response using bode diagrams and the steady state of the system. It allows the user to project noises on system outputs to get spectra of outputs for given input noises spectra. This class is sufficiently general to be used with a variety of systems once the SSM of the system is provided in the library. Furthermore, one of the main objectives of the data analysis for LPF (the estimation of different parameters of the system), can be achieved by a new

  8. Power consumption analysis DBD plasma ozone generator

    Science.gov (United States)

    Nur, M.; Restiwijaya, M.; Muchlisin, Z.; Susan, I. A.; Arianto, F.; Widyanto, S. A.

    2016-11-01

    Studies on the consumption of energy by an ozone generator with various constructions electrodes of dielectric barrier discharge plasma (DBDP) reactor has been carried out. This research was done to get the configuration of the reactor, that is capable to produce high ozone concentrations with low energy consumption. BDBP reactors were constructed by spiral- cylindrical configuration, plasma ozone was generated by high voltage AC voltage up to 25 kV and maximum frequency of 23 kHz. The reactor consists of an active electrode in the form of a spiral-shaped with variation diameter Dc, and it was made by using copper wire with diameter Dw. In this research, we variated number of loops coil windings N as well as Dc and Dw. Ozone concentrations greater when the wire's diameter Dw and the diameter of the coil windings applied was greater. We found that impedance greater will minimize the concentration of ozone, in contrary to the greater capacitance will increase the concentration of ozone. The ozone concentrations increase with augmenting of power. Maximum power is effective at DBD reactor spiral-cylinder is on the Dc = 20 mm, Dw = 1.2 mm, and the number of coil windings N = 10 loops with the resulting concentration is greater than 20 ppm and it consumes energy of 177.60 watts

  9. DISTRIBUTED LEADERSHIP COLLABORATION FACTORS TO SUPPORT IDEA GENERATION IN COMPUTER-SUPPORTED COLLABORATIVE e-LEARNING

    Directory of Open Access Journals (Sweden)

    Niki Lambropoulos

    2011-01-01

    Full Text Available This paper aims to identify, discuss and analyze students’ collaboration factors related to distributed leadership (DL, which correlates with interaction quality evident in idea generation. Scripting computer-supported collaborative e-learning (CSCeL activities based on DL can scaffold students’ interactions that support collaboration and promote idea generation. Furthermore, the associated tools can facilitate collaboration via scripting and shed light on students’ interactions and dialogical sequences. Such detailed planning can result in effective short e-courses. In this case study, 21 MSc students’ teams worked on a DL project within a 2-day e-course at the IT Institute (ITIN, France. The research methods involved a self-reported questionnaire; the Non-Negative Matrix Factorization (NNMF algorithm with qualitative analysis; and outcomes from the Social Network Analysis (SNA tools implemented within the forums. The results indicated that scripting DL based on the identified distributed leadership attributes can support values such as collaboration and can be useful in supporting idea generation in short e-courses.

  10. Identification of noise in linear data sets by factor analysis

    Energy Technology Data Exchange (ETDEWEB)

    Roscoe, B.A.; Hopke, P.K.

    1982-01-01

    With the use of atomic and nuclear methods to analyze samples for a multitude of elements, very large data sets have been generated. Due to the ease of obtaining these results with computerized systems, the elemental data acquired are not always as thoroughly checked as they should be leading to some, if not many, bad data points. It is advantageous to have some feeling for the trouble spots in a data set before it is used for further studies. A technique which has the ability to identify bad data points, after the data has been generated, is classical factor analysis. The ability of classical factor analysis to identify two different types of data errors make it ideally suited for scanning large data sets. Since the results yielded by factor analysis indicate correlations between parameters, one must know something about the nature of the data set and the analytical techniques used to obtain it to confidentially isolate errors.

  11. Generation and Analysis of Random Waves

    DEFF Research Database (Denmark)

    Liu, Zhou; Frigaard, Peter

    applied to hydrology, wind mechanics, ice mechanics, etc., not to mention the fact that spectral analysis comes originally from optics and electronics. The book intents to be a textbook for senior and graduate students who have interest in coastal and offshore structures. The only pre-requirement...

  12. Generative models for pedestrian track analysis

    NARCIS (Netherlands)

    Kooij, J.F.P.

    2015-01-01

    Various problems in tracking and track analysis are addressed, with a focus on applications in the surveillance and intelligent vehicle domains, such as pedestrian path prediction, learning spatial and temporal structure of behavior patterns in data, anomalous track detection, and data association w

  13. Generative models for pedestrian track analysis

    NARCIS (Netherlands)

    Kooij, J.F.P.

    2015-01-01

    Various problems in tracking and track analysis are addressed, with a focus on applications in the surveillance and intelligent vehicle domains, such as pedestrian path prediction, learning spatial and temporal structure of behavior patterns in data, anomalous track detection, and data association

  14. Analysis of Influencing Factors of"Political Man"Role Generation Under Chinese Context%中国语境下"政治人"角色生成影响要素分析

    Institute of Scientific and Technical Information of China (English)

    汪金玉

    2015-01-01

    近代以来特别是改革开放以来,我国民众的政治角色和政治地位发生了根本性的变化.随着社会主义制度的不断巩固和日益完善,尤其是民主政治的深入发展,我国公民的"政治人"角色已经形成并迈向成熟.立足中国语境的分析视角,从外部因素、传统文化以及现实环境三个层面,阐明了中国"政治人"角色生成的几个影响要素,指出中国公民政治角色的演变生成,既是社会主义民主法制建设完善的内在结果,也是社会主义民主法制进步发展的必然要求.%Since the modern times,especially the reform and opening-up,the political role and political status of the Chi-nese people have fundamentally changed. With the consolidation of the socialist system,especially the further development of democratic politics,the"political man"role of Chinese citizens is gradually formed and matured. Based on Chinese context, from three levels of external factors,conventional conditions and reality,this article clarifies several factors affecting China's"political man"role generation,and points out the evolution of Chinese citizens political roles. It is not only the internal re-sult of perfection of socialist democracy and legal system,but also is the inevitable requirement of its development.

  15. Statistical inference of Minimum Rank Factor Analysis

    NARCIS (Netherlands)

    Shapiro, A; Ten Berge, JMF

    2002-01-01

    For any given number of factors, Minimum Rank Factor Analysis yields optimal communalities for an observed covariance matrix in the sense that the unexplained common variance with that number of factors is minimized, subject to the constraint that both the diagonal matrix of unique variances and the

  16. Statistical inference of Minimum Rank Factor Analysis

    NARCIS (Netherlands)

    Shapiro, A; Ten Berge, JMF

    For any given number of factors, Minimum Rank Factor Analysis yields optimal communalities for an observed covariance matrix in the sense that the unexplained common variance with that number of factors is minimized, subject to the constraint that both the diagonal matrix of unique variances and the

  17. Neutrophil biology and the next generation of myeloid growth factors.

    Science.gov (United States)

    Dale, David C

    2009-01-01

    Neutrophils are the body's critical phagocytic cells for defense against bacterial and fungal infections; bone marrow must produce approximately 10 x 10(9) neutrophils/kg/d to maintain normal blood neutrophil counts. Production of neutrophils depends on myeloid growth factors, particularly granulocyte colony-stimulating factor (G-CSF). After the original phase of development, researchers modified these growth factors to increase their size and delay renal clearance, increase their biologic potency, and create unique molecules for business purposes. Pegylated G-CSF is a successful product of these efforts. Researchers have also tried to identify small molecules to serve as oral agents that mimic the parent molecules, but these programs have been less successful. In 2006, the European Medicines Agency established guidelines for the introduction of new biologic medicinal products claimed to be similar to reference products that had previously been granted marketing authorization in the European community, called bio-similars. Globally, new and copied versions of G-CSF and other myeloid growth factors are now appearing. Some properties of the myeloid growth factors are similar to other agents, offering opportunities for the development of alternative drugs and treatments. For example, recent research shows that hematopoietic progenitor cells can be mobilized with a chemokine receptor antagonist, chemotherapy, G-CSF, and granulocyte macrophage colony-stimulating factor. Advances in neutrophil biology coupled with better understanding and development of myeloid growth factors offer great promise for improving the care of patients with cancer and many other disorders.

  18. 3. report of study group 6.2 ''new market for gas - technology evaluation'': factor analysis on penetration of gas cooling; biogas, a renewable energy source; micro- and mini- combined heat and power generation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    Over the past ten years, the hoped for growth of an international air conditioning market fueled by natural gas, has not lived up to expectations. The purpose of this report is to assess causal factors and to pinpoint any key areas for corrective action, if our successes are to be enhanced. We started by evaluating the conditions in the Japanese market that allowed for the most successful penetration of the gas cooling market in the world, and then built a model that describes those conditions. Next we examined the market criteria and constructed models for two cities in the U.S., and for France and Spain, and then compared the results against the Japanese model. Biogas is the name given to a gas mixture with high methane content resulting from the bacteriological fermentation of organic material in an anaerobic environment. In addition to combustible methane gas, the mixture contains carbon dioxide, water and lesser amounts of other components. Today, there is an increased demand in some of the worlds' markets for environmentally friendly and sustainable energy systems. The fact that biogas is just as clean as natural gas and is renewable can be used by the natural gas industry in their efforts to increase gas demand. As natural gas can benefit from biogas, biogas can also benefit from natural gas. Biogas needs the support of the resources of the natural gas industry, such as infrastructure, marketing and research to become one, albeit small, part of our energy supply. IGU SG 6.2 presents in this paper a short description of the possible uses of biogas, a description of the biogas process, the different technologies for production, cleaning and upgrading biogas to natural gas quality, and some of the marketing concepts that have been successfully employed. A world-wide trend towards decentralized power generation is being observed in those countries where electricity is generated in centralized fossil-fuelled power stations. This is due to a variety of

  19. PROGNOSTIC FACTORS ANALYSIS FOR STAGEⅠ RECTAL CANCER

    Institute of Scientific and Technical Information of China (English)

    武爱文; 顾晋; 薛钟麒; 王怡; 徐光炜

    2001-01-01

    To explore the death-related factors of stageⅠrectal cancer patients. Methods: 89 cases of stage I rectal cancer patients between 1985 and 2000 were retrospectively studied for prognostic factors. Factors including age, gender, tumor size, circumferential occupation, gross type, pathological type, depth of tumor invasion, surgical procedure, adjuvant chemotherapy and postoperative complication were chosen for cox multivariate analysis (forward procedure) using Spss software (10.0 version). Results: multivariate analysis demonstrated that muscular invasion was an independent negative prognostic factor for stageⅠrectal cancer patients (P=0.003). Conclusion: Muscular invasion is a negative prognostic factor for stage I rectal cancer patients.

  20. An analysis of factors causing the occurrence of off-design thermally induced force effects in the zone of weld joint no. 111-1 in a PGV-1000M steam generator and recommendations on excluding them

    Science.gov (United States)

    Bakirov, M. B.; Levchuk, V. I.; Povarov, V. P.; Gromov, A. F.

    2014-08-01

    Inadmissible operational flaws occurring in the critical zones of heat-transfer and mechanical equipment are commonly revealed in all nuclear power plant units both in Russia and abroad. The number of such flaws will only grow in the future because the majority of nuclear power plants have been in operation for a time that is either close to or even exceeds the assigned service life. In this connection, establishing cause-and-effect relations with regard to accelerated incipience and growth of flaws, working out compensating measures aimed at reducing operational damageability, and setting up monitoring of equipment integrity degradation of during operation are becoming the matters of utmost importance. There is a need to introduce new approaches to comprehensive diagnostics of the technical state of important nuclear power plant equipment, including continuous monitoring of its operational damageability and the extent of its loading in the most critical zones. Starting from 2011, such a monitoring system has successfully been used for the Novovoronezh NPP Unit 5 in the zone of weld joint no. 111-1 of steam generator no. 4. Based on the results from operation of this system in 2011-2013, unsteady thermally induced force effects (periodic thermal shocks and temperature abnormalities) were reveled, which had not been considered in the design, and which have an essential influence on the operational loading of this part. Based on an analysis of cause-and-effect relations pertinent to temperature abnormalities connected with technological operations, a set of measures aimed at reducing the thermally induced force loads exerted on pipeline sections was developed, which includes corrections to the process regulations for safe operation and to the operating manuals (involving changes in the algorithms for manipulating with the stop and control valves in the steam generator blowdown system).

  1. Next Generation Nuclear Plant GAP Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    Ball, Sydney J [ORNL; Burchell, Timothy D [ORNL; Corwin, William R [ORNL; Fisher, Stephen Eugene [ORNL; Forsberg, Charles W. [Massachusetts Institute of Technology (MIT); Morris, Robert Noel [ORNL; Moses, David Lewis [ORNL

    2008-12-01

    As a follow-up to the phenomena identification and ranking table (PIRT) studies conducted recently by NRC on next generation nuclear plant (NGNP) safety, a study was conducted to identify the significant 'gaps' between what is needed and what is already available to adequately assess NGNP safety characteristics. The PIRT studies focused on identifying important phenomena affecting NGNP plant behavior, while the gap study gives more attention to off-normal behavior, uncertainties, and event probabilities under both normal operation and postulated accident conditions. Hence, this process also involved incorporating more detailed evaluations of accident sequences and risk assessments. This study considers thermal-fluid and neutronic behavior under both normal and postulated accident conditions, fission product transport (FPT), high-temperature metals, and graphite behavior and their effects on safety. In addition, safety issues related to coupling process heat (hydrogen production) systems to the reactor are addressed, given the limited design information currently available. Recommendations for further study, including analytical methods development and experimental needs, are presented as appropriate in each of these areas.

  2. Economic analysis of nuclear power generation

    Energy Technology Data Exchange (ETDEWEB)

    Song, Ki Dong; Choi, Young Myung; Kim, Hwa Sup; Lee, Man Ki; Moon, Kee Hwan; Kim, Seung Su; Chae, Kyu Nam

    1996-12-01

    The major contents in this study are as follows : (1) Efforts are made to examine the role of nuclear energy considering environmental regulation. An econometric model for energy demand and supply including carbon tax imposition is established. (2) Analysis for the learning effect of nuclear power plant operation is performed. The study is focused to measure the effect of technology homogeneity on the operation performance. (3) A preliminary capital cost of the KALIMER is estimated by using cost computer program, which is developed in this study. (author). 36 refs.,46 tabs., 15 figs.

  3. Design, Prototyping, and Analysis of a Novel Modular Permanent Magnet Transverse Flux Disk Generator

    DEFF Research Database (Denmark)

    Hosseini, Seyedmohsen; Moghani, Javad Shokrollahi; Ershad, Nima Farrokhzad;

    2011-01-01

    This paper presents the design, prototyping, and analysis of a novel modular transverse flux permanent magnet disk generator. The disk-shaped structure simplifies the construction procedure by using laminated steel sheets. To reduce output harmonics, the excitation of the generator is done...... by circular flat shaped Nd-Fe-B permanent magnets. First, a typical low power generator is designed, and then partially optimized. The optimization objective is to find an inner radius which maximizes the power factor, the output power to mass ratio and the efficiency. The generator equivalent circuit...... parameters are computed by three dimensional finite element analyses. The simulation results show that the power factor of the proposed structure is considerably greater than the power factor previously reported for other transverse flux permanent magnet generator structures. To verify the simulation results...

  4. Second law analysis of an infinitely segmented magnetohydrodynamic generator

    Science.gov (United States)

    Arash, Ardeshir; Saidi, Mohammad Hassan; Najafi, Mohammad

    2017-03-01

    The performance of an infinitely segmented magnetohydrodynamic generator is analyzed using the second law of thermodynamics entropy generation criterion. The exact analytical solution of the velocity and temperature fields are provided by applying the modified Hartmann flow model, taking into account the occurrence of the Hall effect in the considered generator. Contributions of heat transfer, fluid friction, and ohmic dissipation to the destruction of useful available work are found, and the nature of irreversibilities in the considered generator is determined. In addition, the electrical isotropic efficiency scheme is used to evaluate the generator performance. Finally, the implication of the Hall parameter, Hartmann number, and load factor for the entropy generation and the generator performance are studied and the optimal operating conditions are determined. The results show that the heat transfer has the smallest contribution to the entropy generation compared to that of the friction and ohmic dissipation. The application of the Hall effect on the system showed an appreciable augmentation of entropy generation rate which is along with what the logic implies. A parametric study is conducted and its results provide the generated entropy and also efficiency diagrams which show the influence of the Hall effect on the considered generator.

  5. Determining the Number of Factors to Retain in an Exploratory Factor Analysis Using Comparison Data of Known Factorial Structure

    Science.gov (United States)

    Ruscio, John; Roche, Brendan

    2012-01-01

    Exploratory factor analysis (EFA) is used routinely in the development and validation of assessment instruments. One of the most significant challenges when one is performing EFA is determining how many factors to retain. Parallel analysis (PA) is an effective stopping rule that compares the eigenvalues of randomly generated data with those for…

  6. Kernel Factor Analysis Algorithm with Varimax

    Institute of Scientific and Technical Information of China (English)

    Xia Guoen; Jin Weidong; Zhang Gexiang

    2006-01-01

    Kernal factor analysis (KFA) with varimax was proposed by using Mercer kernel function which can map the data in the original space to a high-dimensional feature space, and was compared with the kernel principle component analysis (KPCA). The results show that the best error rate in handwritten digit recognition by kernel factor analysis with varimax (4.2%) was superior to KPCA (4.4%). The KFA with varimax could more accurately image handwritten digit recognition.

  7. Studying the factors affecting solar power generation systems performance ( SPGSP)

    OpenAIRE

    Jalal A Al-Tabtabaei

    2014-01-01

    Solar energy is a huge, clean and renewable source of energy. It is also available everywhere on the earth. However, there are many technical and economic difficulties need to be solved so that solar energy becomes a strong competition against the traditional energy sources. Energy from the sun can be used successfully in electric power generation systems. Depending on the climate conditions and the use of a properly designed, installing and maintained system can meet a large dema...

  8. Transient stability analysis of a distribution network with distributed generators

    NARCIS (Netherlands)

    Xyngi, I.; Ishchenko, A.; Popov, M.; Van der Sluis, L.

    2009-01-01

    This letter describes the transient stability analysis of a 10-kV distribution network with wind generators, microturbines, and CHP plants. The network being modeled in Matlab/Simulink takes into account detailed dynamic models of the generators. Fault simulations at various locations are investigat

  9. Generation mean analysis of dual purpose traits in cowpea (Vigna ...

    African Journals Online (AJOL)

    Fadiji

    2012-06-07

    Jun 7, 2012 ... Key words: Gene effects, fodder, Vigna unguiculata, generation mean analysis. .... distribution pattern of fodder yield in the various crosses, the field ...... Tropical Agriculture (IITA), and Japan International Research Center.

  10. Assessment and analysis of wind energy generation and power ...

    African Journals Online (AJOL)

    of proportional integral controller is simulated using software Matlab/Simulink, studies on a 2 MW DFIG wind generation ...... control rule database consists of series "IF-. AND-THEN" ..... for wind energy analysis, Journal of Wind Engineering.

  11. Multiple factor analysis by example using R

    CERN Document Server

    Pagès, Jérôme

    2014-01-01

    Multiple factor analysis (MFA) enables users to analyze tables of individuals and variables in which the variables are structured into quantitative, qualitative, or mixed groups. Written by the co-developer of this methodology, Multiple Factor Analysis by Example Using R brings together the theoretical and methodological aspects of MFA. It also includes examples of applications and details of how to implement MFA using an R package (FactoMineR).The first two chapters cover the basic factorial analysis methods of principal component analysis (PCA) and multiple correspondence analysis (MCA). The

  12. Analysis of Factors Affecting the Quality of an E-commerce Website Using Factor Analysis

    Directory of Open Access Journals (Sweden)

    Saurabh Mishra

    2014-12-01

    Full Text Available The purpose of this study is to identify factors which affect the quality and effectiveness of an e commerce website which also majorly affect customer satisfaction and ultimately customer retention and loyalty. This research paper examines a set of 23 variables and integrates them into 4 factors which affect the quality of a website. An online questionnaire survey was conducted to generate statistics regarding the preferences of the e-commerce website users.The 23 variables taken from customer survey are generalized into 4 major factors using exploratory factor analysis which are content, navigation, services and interface design. The research majorly consists of the responses of students between the age group of 18-25 years and considers different B2C commercial websites. Identified variables are important with respect to the current competition in the market as service of an e-commerce website also play a major role in ensuring customer satisfaction. Further research in this domain can be done for websites’ version for mobile devices.

  13. Vibration analysis of a hydro generator for different operating regimes

    Science.gov (United States)

    Haţiegan, C.; Pădureanu, I.; Jurcu, M.; Nedeloni, M. D.; Hamat, C. O.; Chioncel, C. P.; Trocaru, S.; Vasile, O.; Bădescu, O.; Micliuc, D.; (Filip Nedeloni, L.; Băra, A.; (Barboni Haţiegan, L.

    2017-01-01

    Based on experimental measurements, this paper presents the vibration analysis of a hydro generator that equips a Kaplan hydraulic turbine of a Hydropower plant in Romania. This analysis means vibrations measurement to different operating regimes of the hydro generator respectively before installing it and into operation, namely putting off load mode (unexcited and excited) respectively putting on load mode. By comparing, through the experimental results obtained before and after the operation of hydro aggregates are observed vibrations improvements.

  14. Sulfur Flow Analysis for New Generation Steel Manufacturing Process

    Institute of Scientific and Technical Information of China (English)

    HU Chang-qing; ZHANG Chun-xia; HAN Xiao-wei; YIN Rui-yu

    2008-01-01

    Sulfur flow for new generation steel manufacturing process is analyzed by the method of material flow analysis,and measures for SO2 emission reduction are put forward as assessment and target intervention of the results.The results of sulfur flow analysis indicate that 90% of sulfur comes from fuels.Sulfur finally discharges from the steel manufacturing route in various steps,and the main point is BF and BOF slag desulfurization.In sintering process,the sulfur is removed by gasification,and sintering process is the main source of SO2 emission.The sulfur content of coke oven gas (COG) is an important factor affecting SO2 emission.Therefore,SO2 emission reduction should be started from the optimization and integration of steel manufacturing route,sulfur burden should be reduced through energy saving and consumption reduction,and the sulfur content of fuel should be controlled.At the same time,BF and BOF slag desulfurization should be optimized further and coke oven gas and sintering exhausted gas desulfurization should be adopted for SO2 emission reduction and reuse of resource,to achieve harmonic coordination of economic,social,and environmental effects for sustainable development.

  15. Modeling and analysis of solar distributed generation

    Science.gov (United States)

    Ortiz Rivera, Eduardo Ivan

    power point tracking algorithms. Finally, several PV power applications will be presented like circuit analysis for a load connected to two different PV arrays, speed control for a do motor connected to a PVM, and a novel single phase photovoltaic inverter system using the Z-source converter.

  16. Transient Current Analysis of Induction Generators for Wind Power Generating System

    Science.gov (United States)

    Senjyu, Tomonobu; Sueyoshi, Norihide; Uezato, Katsumi; Fujita, Hideki

    In recent year, non-conventional energy generation is coming up for effective use of natural energy, such as wind energy. Induction generators consisting squirrel-cage rotors are widly used as wind generators because of their salient features like robust rotor design, simple in the construction, maintenance free operation, etc. However these induction generators will draw large transient inrush current, several times as large as the machine rated current, the instant when they are connected to utility grid or restored after the fault clearance. Under such situations, there will be a severe voltage fluctuations in the power system. In this paper, we present transient analysis of induction generators before and after a three-phase fault conditions. Theoretical discission is developed to determine the initial phase angle and the time at which maximum transient currents flow in the system.

  17. A small - signal stability analysis of DFIG wind generation

    OpenAIRE

    Vittal, Eknath; O'Malley, Mark; Keane, Andrew

    2009-01-01

    This paper examines the small-signal stability impacts of high penetrations of doubly-fed induction generator (DFIG) wind turbines on power systems. It provides a basic overview of small-signal stability concepts and then examines the response of DFIG generation to two local contingency event. Using the New England 39 bus test system, this paper will demonstrate the stability implications of DFIG turbines utilizing terminal voltage control and fixed power factor control in response...

  18. ANALYSIS OF INTERNALLY GENERATED NOISE OF BIOELECTRIC AMPLIFIERS

    Institute of Scientific and Technical Information of China (English)

    Mashhour Mustafa; Bani Amer

    2003-01-01

    This paper deals with internally generated noise of bioelectric amplifiers that are usually used for processing of bioelectric events. The main purpose of this paper is to present a procedure for analysis of the effects of internal noise generated by the active circuits and to evaluate the output noise of the author's new designed bioelectric amplifier that caused by internal effects to the amplifier circuit itself in order to compare it with the noise generated by conventional amplifiers. The obtained analysis results of internally generated noise showed that the total output noise of bioelectric active circuits does not increase when some of their resistors have a larger value. This behavior is caused by the different transfer functions for the signal and the respective noise sources associated with these resistors. Moreover, the new designed bioelectric amplifier has an output noise less than that for conventional amplifiers. The obtained analysis results were also experimentally verified and the final conclusions were drawn.

  19. Determining Dimensionality of Exercise Readiness Using Exploratory Factor Analysis

    Directory of Open Access Journals (Sweden)

    Kelley Strohacker, Rebecca A. Zakrajsek

    2016-06-01

    Full Text Available Assessment of “exercise readiness” is a central component to the flexible non-linear periodization (FNLP method of organizing training workloads, but the underlying factor structure of this construct has not been empirically determined. The purpose of this study was to assess construct dimensionality of exercise readiness using exploratory factor analysis. The result of which serve as initial steps of developing a brief measure of exercise readiness. Participants consisted of students recruited from undergraduate Kinesiology courses at a racially diverse, southern University. Independent, anonymous online survey data were collected across three stages: 1 generation of item pool (n = 290, 2 assessment of face validity and refinement of item pool (n = 168, and 3 exploratory factor analysis (n = 684. A principal axis factor analysis was conducted with 41 items using oblique rotation (promax. Four statistically significant factors, as determined through parallel analysis, explained 61.5% of the variance in exercise readiness. Factor 1 contained items that represented vitality (e.g., lively, revived. Factor 2 items related to physical fatigue (e.g. tired, drained. Factors 3 and 4 were descriptive of, discomfort (e.g. pain, sick and health (i.e. healthy, fit, respectively. This inductive approach indicates that exercise readiness is comprised of four dimensions: vitality, physical fatigue, discomfort, and health. This finding supports readiness assessment techniques currently recommended for practitioners according to the FNLP model. These results serve as a theoretical foundation upon which to further develop and refine a brief survey instrument to measure exercise readiness.

  20. Analysis of the generation mechanism and influencing factors on sympathetic inrush in initial period of power system restoration%电网恢复初期和应涌流产生机理及影响因素分析

    Institute of Scientific and Technical Information of China (English)

    龚薇; 刘俊勇; 贺星棋; 张国松

    2012-01-01

    In the initial period of power system restoration, the sympathetic inrush current will appear as a result of the saturation when charging no-load transformer. Based on the mathematical representations of flux linkage and the integral model of sympathetic inrush of two shunt-wound transforms in initial period of power system restoration, this paper indicates that sympathetic inrush is generated through the change of linkage of running transformer by sudden change of public bus voltage in two shunt-wound transformers. The sympathetic inrush value is decided by the integral value of public bus voltage in a period. Then the influence of system impedance, load capacity and load power factor that has been restored on sympathetic inrush current is analyzed in-depth. The analytical results are tested and verified by computer simulation and useful conclusion and reference are provided for estimating sympathetic inrush current.%系统恢复初期,在空充主变的过程中由于其饱和导致和应涌流现象.针对该问题,从并联的两台变压器磁链解析式与和应涌流的积分表达式出发,指出和应涌流主要是由并联变压器公共点处电压的突变造成运行变压器的磁链改变而产生的,其大小由并联公共点处电压在一个周期内的积分值决定.然后深入分析了系统阻抗、运行变压器所带负荷量及负荷功率因数对和应涌流产生的影响.利用计算机仿真验证了分析的结论,为正确认识系统恢复初期和应涌流现象提供了有益的结论与参考.

  1. Windfarm Generation Assessment for Reliability Analysis of Power Systems

    DEFF Research Database (Denmark)

    Barberis Negra, Nicola; Bak-Jensen, Birgitte; Holmstrøm, O.

    2007-01-01

    Due to the fast development of wind generation in the past ten years, increasing interest has been paid to techniques for assessing different aspects of power systems with a large amount of installed wind generation. One of these aspects concerns power system reliability. Windfarm modelling plays...... in a reliability model and the generation of a windfarm is evaluated by means of sequential Monte Carlo simulation. Results are used to analyse how each mentioned Factor influences the assessment, and why and when they should be included in the model....

  2. Windfarm Generation Assessment for ReliabilityAnalysis of Power Systems

    DEFF Research Database (Denmark)

    Negra, Nicola Barberis; Holmstrøm, Ole; Bak-Jensen, Birgitte

    2007-01-01

    Due to the fast development of wind generation in the past ten years, increasing interest has been paid to techniques for assessing different aspects of power systems with a large amount of installed wind generation. One of these aspects concerns power system reliability. Windfarm modelling plays...... in a reliability model and the generation of a windfarm is evaluated by means of sequential Monte Carlo simulation. Results are used to analyse how each mentioned Factor influences the assessment, and why and when they should be included in the model....

  3. Analysis of brushless DC generator incorporating an axial field coil

    Energy Technology Data Exchange (ETDEWEB)

    Moradi, Hassan, E-mail: H_moradi@sbu.ac.i [Department of Electrical and Computer Engineering, Shahid Beheshti University, GC, Tehran (Iran, Islamic Republic of); Afjei, E. [Department of Electrical and Computer Engineering, Shahid Beheshti University, GC, Tehran (Iran, Islamic Republic of)

    2011-07-15

    Highlights: {yields} Magnetic analysis and experiment of a three-phase field assisted BLDC generator. {yields} Confirm the accuracy of the predicted flux-linkage by 2-D FE analysis. {yields} Confirm the accuracy of the FE analysis results by coupling the FE and BE method. {yields} Control the output voltage to a desired level by control the amplitude of the I{sub f}. {yields} Compatible with any application that requires variable speed operation. -- Abstract: This paper describes the magnetic analysis and experiment of a three-phase field assisted brushless DC (BLDC) generator. Unlike conventional BLDC generators, the permanent magnet is replaced with an assisted field winding. The stator and rotor are constructed with two dependent magnetically sets, in which each stator set includes nine salient poles with coil windings, and the rotor comprises of six salient poles. Other pole combinations also are possible. This construction is similar to a homopolar inductor alternator. The DC current in the assisted field winding produces axial flux which makes the rotor magnetically polarized at its ends. The magnetic field flows axially through the rotor shaft and closes through the stator teeth and the machine housing. To evaluate the generator performance, two types of analysis, namely the numerical technique and the experimental study have been utilized. In the numerical analysis, 2-D finite element (FE) analysis has been carried out using a MagNet CAD package (Infolytica Corporation Ltd.), to confirm the accuracy of the predicted flux-linkage characteristics, whereas in the experimental study, a prototype BLDC generator was constructed for verifying the actual performance. Furthermore, the evaluation method based on a hybrid numerical method coupling the finite element (FE) analysis and boundary element (BE) method, has been carried out to confirm the accuracy of the 2-D FE analysis simulation results. It provides not only confirmations of the investigation in results

  4. Genetic Analysis of Early Generation Stability in Rice

    Institute of Scientific and Technical Information of China (English)

    ZHOU Li-Jun; Ao Guang-Hui; XIAO Yi; WU Xian-Jun; LI Shi-Gui

    2005-01-01

    The mechanism of early generation stability (EGS) in rice was studied via genetic analysis. Three types of crosses were made, namely between EGS varieties, EGS and conventional rice variety, and conventional rice varieties. The genetic analysis was based on the stable lines in F2 population. The stable lines may appear from some combinations of EGS rice crossing with each other and EGS rice crossing with conventional varieties at different frequencies, but stable lines didn't appear in conventional varieties crossing with conventional varieties. Genetic analysis results indicated that the EGS phenomena should just exist in special rice materials, and the frequency of stable lines was closely related to the EGS traits of parents. The EGS traits were neither qualitative nor quantitative traits, and they were controlled by neither dominant genes nor recessive genes. The EGS traits might be inherited by F1 single plant, and the traits of F3 and F4 were corresponded to those of F2 population, i.e. F3 and F4 lines derived from non-segregating F2 showed uniform agronomic traits, and those from segregating F2.did not. The agronomic traits of EGS lines were consistent with those of F1 single plant. On the other hand, when EGS lines occurred, the segregating lines in Mendelian manner were also observed in all F2 population of the same combination. It was suggested that the reason why the stable strains occurred might be a special factor to control (open/close) gene at the beginning of cell division in zygote, resulting in closing mitosis and opening somatic reduction. The somatic reduction of zygote resulted in recombination and homozygosity forming in F1 single plant,and some lines with uniform agronomic traits were observed in some lines of F2 population.

  5. TEACHING Y GENERATION - INFLUENCING FACTORS AND CONSEQUENCES FOR ECONOMIC EDUCATION

    Directory of Open Access Journals (Sweden)

    Botezat Elena

    2014-07-01

    We test these hypotheses using a test administrated for 22 students in Management, enrolled in the second year, undergraduate studies. Then we include in our present paper the empirical results in order to show that all three hypotheses were confirmed. The results are presented with a thought description of the empirical analysis. Finally, discussion and conclusions are presented and implications for economic education are discussed.

  6. Factoring Adult Learners’ Generational Mix in Translator Education

    Directory of Open Access Journals (Sweden)

    Sakwe George Mbotake

    2016-07-01

    Full Text Available This study assesses the incidence of androgogical principles and practices in the postgraduate Translator Training programme of the Advanced School of Translators and Interpreters (ASTI in Cameroon.  It posits that teaching that engages androgogical principles and practices are more germane to professional postgraduate Translator Training programmes that educate and service adult students.  As a relatively uncharted area in Translation Studies, the paper seeks to assess students and faculty’s attitudes towards the principles and practices of adult education and the difficulties encountered in their effective implementation. The aim of the study is to recommend androgogically-oriented translation teaching methods as a more effective alternative to effete pedagogical approaches.   The subjects for this study comprised a convenience sample of 41 trainee translators and 08 translator trainers of ASTI. Three data collection methods were used: an affective survey questionnaire, classroom observation, and a literature review component, which provided empirical data on the principles and practices of andragogy and pedagogy. The study demonstrates that knowledge of adult learners goes beyond the most commonly studied demographic variables of age and gender, and uncovers new variables that influence learning and student satisfaction in Translator Training. Keywords: Higher Education, Translator Training, Adult Education, Androgogy, Generational Mix

  7. Neuromuscular factors contributing to in vivo eccentric moment generation.

    Science.gov (United States)

    Webber, S; Kriellaars, D

    1997-07-01

    Muscle series elasticity and its contribution to eccentric moment generation was examined in humans. While subjects [male, n = 30; age 26.3 +/- 4.8 (SD) yr; body mass 78.8 +/- 13.1 kg] performed an isometric contraction of the knee extensors at 60 degrees of knee flexion, a quick stretch was imposed with a 12 degrees -step displacement at 100 degrees /s. The test was performed at 10 isometric activation levels ranging from 1.7 to 95.2% of maximal voluntary contraction (MVC). A strong linear relationship was observed between the peak imposed eccentric moment derived from quick stretch and the isometric activation level (y = 1.44x + 7.08; r = 0.99). This increase in the eccentric moment is consistent with an actomyosin-dependent elasticity located in series with the contractile element of muscle. By extrapolating the linear relationship to 100% MVC, the predicted maximum eccentric moment was found to be 151% MVC, consistent with in vitro data. A maximal voluntary, knee extensor strength test was also performed (5-95 degrees, 3 repetitions, +/-50, 100, 150, 200, and 250 degrees/s). The predicted maximum eccentric moment was 206% of the angle- and velocity-matched, maximal voluntary eccentric moments. This was attributed to a potent neural regulatory mechanism that limits the recruitment and/or discharge of motor units during maximal voluntary eccentric contractions.

  8. Analysis on Operation Reliability of Generating Units in 2005

    Institute of Scientific and Technical Information of China (English)

    Zuo Xiaowen; Chu Xue

    2007-01-01

    @@ The weighted average equivalent availability factor of thermal power units in 2005 was 92.34%, an increase of 0.64 percentage points as compared to that in 2004. The average equivalent availability factor in 2005 was 92.22%, a decrease of 0.95 percentage points as compared to that in 2004. The nationwide operation reliability of generating units in 2005 was analyzed completely in this paper.

  9. Factors associated with the satisfaction of millennial generation dental residents.

    Science.gov (United States)

    Lam, Hwai-Tai C; O'Toole, Terry G; Arola, Patricia E; Kashner, T Michael; Chang, Barbara K

    2012-11-01

    Data from the 2010 Learners' Perceptions Survey (LPS) administered through the Office of Academic Affiliations, Department of Veterans Affairs (VA) were analyzed to identify factors associated with dental residents' satisfaction with the VA as a clinical training environment. Satisfaction scores were linked to clinic workloads, dental procedure complexity levels, staffing patterns, and facility infrastructure data to explore conditions that may improve residents' satisfaction. Findings supported the construct validity of the LPS survey data and underscored the importance of maintaining optimal ratios of attending dentists, dental assistants, and administrative staff to residents so that each trainee will have opportunities to perform an adequate level of dental workload. As programs strive to improve the quality of graduate dental education, findings from this study are vital for setting curriculum design guidelines and for providing infrastructure support for dental resident education.

  10. Principal component analysis of cardiovascular risk traits in three generations cohort among Indian Punjabi population

    Directory of Open Access Journals (Sweden)

    Badaruddoza

    2015-09-01

    Full Text Available The current study focused to determine significant cardiovascular risk factors through principal component factor analysis (PCFA among three generations on 1827 individuals in three generations including 911 males (378 from offspring, 439 from parental and 94 from grand-parental generations and 916 females (261 from offspring, 515 from parental and 140 from grandparental generations. The study performed PCFA with orthogonal rotation to reduce 12 inter-correlated variables into groups of independent factors. The factors have been identified as 2 for male grandparents, 3 for male offspring, female parents and female grandparents each, 4 for male parents and 5 for female offspring. This data reduction method identified these factors that explained 72%, 84%, 79%, 69%, 70% and 73% for male and female offspring, male and female parents and male and female grandparents respectively, of the variations in original quantitative traits. The factor 1 accounting for the largest portion of variations was strongly loaded with factors related to obesity (body mass index (BMI, waist circumference (WC, waist to hip ratio (WHR, and thickness of skinfolds among all generations with both sexes, which has been known to be an independent predictor for cardiovascular morbidity and mortality. The second largest components, factor 2 and factor 3 for almost all generations reflected traits of blood pressure phenotypes loaded, however, in male offspring generation it was observed that factor 2 was loaded with blood pressure phenotypes as well as obesity. This study not only confirmed but also extended prior work by developing a cumulative risk scale from factor scores. Till today, such a cumulative and extensive scale has not been used in any Indian studies with individuals of three generations. These findings and study highlight the importance of global approach for assessing the risk and need for studies that elucidate how these different cardiovascular risk factors

  11. Key factors affecting the deployment of electricity generation technologies in energy technology scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Ruoss, F.; Turton, H.; Hirschberg, S.

    2009-12-15

    This report presents the findings of a survey of key factors affecting the deployment of electricity generation technologies in selected energy scenarios. The assumptions and results of scenarios, and the different models used in their construction, are compared. Particular attention is given to technology assumptions, such as investment cost or capacity factors, and their impact on technology deployment. We conclude that the deployment of available technologies, i.e. their market shares, can only be explained from a holistic perspective, and that there are strong interactions between driving forces and competing technology options within a certain scenario. Already the design of a scenario analysis has important impacts on the deployment of technologies: the choice of the set of available technologies, the modeling approach and the definition of the storylines determine the outcome. Furthermore, the quantification of these storylines into input parameters and cost assumptions drives technology deployment, even though differences across the scenarios in cost assumptions are not observed to account for many of the observed differences in electricity technology deployment. The deployment can only be understood after a consideration of the interplay of technology options and the scale of technology deployment, which is determined by economic growth, end-use efficiency, and electrification. Some input parameters are of particular importance for certain technologies: CO{sub 2} prices, fuel prices and the availability of carbon capture and storage appear to be crucial for the deployment of fossil-fueled power plants; maximum construction rates and safety concerns determine the market share of nuclear power; the availability of suitable sites represents the most important factor for electricity generation from hydro and wind power plants; and technology breakthroughs are needed for solar photovoltaics to become cost-competitive. Finally, this analysis concludes with a

  12. Generation and Analysis of Algorithms for the Study of QBDs

    Directory of Open Access Journals (Sweden)

    Ricardo C. Goméz-Vargas

    2013-11-01

    Full Text Available The analysis and characterization of telecommunication systems generally is performed using stochastic models, this paper presents two algorithms for the analysis of quasi birth and death (QBDs, these are implemented on two types of queues PH/PH/1 and M/M/1, showing the results of these and comparing their execution times and error results. For development work using matrix analysis based on Markov chains begins from his generated matrix.

  13. Kernel parameter dependence in spatial factor analysis

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg

    2010-01-01

    feature space via the kernel function and then performing a linear analysis in that space. In this paper we shall apply a kernel version of maximum autocorrelation factor (MAF) [7, 8] analysis to irregularly sampled stream sediment geochemistry data from South Greenland and illustrate the dependence...

  14. Multistructure Statistical Model Applied To Factor Analysis

    Science.gov (United States)

    Bentler, Peter M.

    1976-01-01

    A general statistical model for the multivariate analysis of mean and covariance structures is described. Matrix calculus is used to develop the statistical aspects of one new special case in detail. This special case separates the confounding of principal components and factor analysis. (DEP)

  15. Factors that influence the generation of autobiographical memory conjunction errors.

    Science.gov (United States)

    Devitt, Aleea L; Monk-Fromont, Edwin; Schacter, Daniel L; Addis, Donna Rose

    2016-01-01

    The constructive nature of memory is generally adaptive, allowing us to efficiently store, process and learn from life events, and simulate future scenarios to prepare ourselves for what may come. However, the cost of a flexibly constructive memory system is the occasional conjunction error, whereby the components of an event are authentic, but the combination of those components is false. Using a novel recombination paradigm, it was demonstrated that details from one autobiographical memory (AM) may be incorrectly incorporated into another, forming AM conjunction errors that elude typical reality monitoring checks. The factors that contribute to the creation of these conjunction errors were examined across two experiments. Conjunction errors were more likely to occur when the corresponding details were partially rather than fully recombined, likely due to increased plausibility and ease of simulation of partially recombined scenarios. Brief periods of imagination increased conjunction error rates, in line with the imagination inflation effect. Subjective ratings suggest that this inflation is due to similarity of phenomenological experience between conjunction and authentic memories, consistent with a source monitoring perspective. Moreover, objective scoring of memory content indicates that increased perceptual detail may be particularly important for the formation of AM conjunction errors.

  16. Historical and contemporary factors generate unique butterfly communities on islands

    Science.gov (United States)

    Vodă, Raluca; Dapporto, Leonardo; Dincă, Vlad; Shreeve, Tim G.; Khaldi, Mourad; Barech, Ghania; Rebbas, Khellaf; Sammut, Paul; Scalercio, Stefano; Hebert, Paul D. N.; Vila, Roger

    2016-06-01

    The mechanisms shaping island biotas are not yet well understood mostly because of a lack of studies comparing eco-evolutionary fingerprints over entire taxonomic groups. Here, we linked community structure (richness, frequency and nestedness) and genetic differentiation (based on mitochondrial DNA) in order to compare insular butterfly communities occurring over a key intercontinental area in the Mediterranean (Italy-Sicily-Maghreb). We found that community characteristics and genetic structure were influenced by a combination of contemporary and historical factors, and among the latter, connection during the Pleistocene had an important impact. We showed that species can be divided into two groups with radically different properties: widespread taxa had high dispersal capacity, a nested pattern of occurrence, and displayed little genetic structure, while rare species were mainly characterized by low dispersal, high turnover and genetically differentiated populations. These results offer an unprecedented view of the distinctive butterfly communities and of the main processes determining them on each studied island and highlight the importance of assessing the phylogeographic value of populations for conservation.

  17. [Automatic analysis pipeline of next-generation sequencing data].

    Science.gov (United States)

    Wenke, Li; Fengyu, Li; Siyao, Zhang; Bin, Cai; Na, Zheng; Yu, Nie; Dao, Zhou; Qian, Zhao

    2014-06-01

    The development of next-generation sequencing has generated high demand for data processing and analysis. Although there are a lot of software for analyzing next-generation sequencing data, most of them are designed for one specific function (e.g., alignment, variant calling or annotation). Therefore, it is necessary to combine them together for data analysis and to generate interpretable results for biologists. This study designed a pipeline to process Illumina sequencing data based on Perl programming language and SGE system. The pipeline takes original sequence data (fastq format) as input, calls the standard data processing software (e.g., BWA, Samtools, GATK, and Annovar), and finally outputs a list of annotated variants that researchers can further analyze. The pipeline simplifies the manual operation and improves the efficiency by automatization and parallel computation. Users can easily run the pipeline by editing the configuration file or clicking the graphical interface. Our work will facilitate the research projects using the sequencing technology.

  18. A Review of Operational Water Consumption and Withdrawal Factors for Electricity Generating Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Macknick, Jordan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Newmark, Robin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Heath, Garvin [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hallett, K. C. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2011-03-01

    This report provides estimates of operational water withdrawal and water consumption factors for electricity generating technologies in the United States. Estimates of water factors were collected from published primary literature and were not modified except for unit conversions. The presented water factors may be useful in modeling and policy analyses where reliable power plant level data are not available.

  19. Economical analysis of combined fuel cell generators and absorption chillers

    Directory of Open Access Journals (Sweden)

    M. Morsy El-Gohary

    2013-06-01

    Full Text Available This paper presents a co-generation system based on combined heat and power for commercial units. For installation of a co-generation system, certain estimates for this site should be performed through making assessments of electrical loads, domestic water, and thermal demand. This includes domestic hot water, selection of the type of power generator, fuel cell, and the type of air conditioning system, and absorption chillers. As a matter of fact, the co-generation system has demonstrated good results for both major aspects, economic and environmental. From the environmental point of view, this can be considered as an ideal solution for problems concerned with the usage of Chlorofluoro carbons. On the other hand, from the economic point of view, the cost analysis has revealed that the proposed system saves 4% of total cost through using the co-generation system.

  20. Theoretical analysis of tsunami generation by pyroclastic flows

    Science.gov (United States)

    Watts, P.; Waythomas, C.F.

    2003-01-01

    Pyroclastic flows are a common product of explosive volcanism and have the potential to initiate tsunamis whenever thick, dense flows encounter bodies of water. We evaluate the process of tsunami generation by pyroclastic flow by decomposing the pyroclastic flow into two components, the dense underflow portion, which we term the pyroclastic debris flow, and the plume, which includes the surge and coignimbrite ash cloud parts of the flow. We consider five possible wave generation mechanisms. These mechanisms consist of steam explosion, pyroclastic debris flow, plume pressure, plume shear, and pressure impulse wave generation. Our theoretical analysis of tsunami generation by these mechanisms provides an estimate of tsunami features such as a characteristic wave amplitude and wavelength. We find that in most situations, tsunami generation is dominated by the pyroclastic debris flow component of a pyroclastic flow. This work presents information sufficient to construct tsunami sources for an arbitrary pyroclastic flow interacting with most bodies of water. Copyright 2003 by the American Geophysical Union.

  1. Windfarm Generation Assessment for Reliability Analysis of Power Systems

    DEFF Research Database (Denmark)

    Barberis Negra, Nicola; Bak-Jensen, Birgitte; Holmstrøm, O.

    2007-01-01

    a significant role in this assessment and different models have been created for it, but a representation which includes all of them has not been developed yet. This paper deals with this issue. First, a list of nine influencing Factors is presented and discussed. Secondly, these Factors are included...... in a reliability model and the generation of a windfarm is evaluated by means of sequential Monte Carlo simulation. Results are used to analyse how each mentioned Factor influences the assessment, and why and when they should be included in the model....

  2. Windfarm Generation Assessment for ReliabilityAnalysis of Power Systems

    DEFF Research Database (Denmark)

    Negra, Nicola Barberis; Holmstrøm, Ole; Bak-Jensen, Birgitte

    2007-01-01

    a significant role in this assessment and different models have been created for it, but a representation which includes all of them has not been developed yet. This paper deals with this issue. First, a list of nine influencing Factors is presented and discussed. Secondly, these Factors are included...... in a reliability model and the generation of a windfarm is evaluated by means of sequential Monte Carlo simulation. Results are used to analyse how each mentioned Factor influences the assessment, and why and when they should be included in the model....

  3. Asymmetry Factors Shaping Regular and Irregular Bursting Rhythms in Central Pattern Generators

    Science.gov (United States)

    Elices, Irene; Varona, Pablo

    2017-01-01

    Central Pattern Generator (CPG) circuits are neural networks that generate rhythmic motor patterns. These circuits are typically built of half-center oscillator subcircuits with reciprocally inhibitory connections. Another common property in many CPGs is the remarkable rich spiking-bursting dynamics of their constituent cells, which balance robustness and flexibility to generate their joint coordinated rhythms. In this paper, we use conductance-based models and realistic connection topologies inspired by the crustacean pyloric CPG to address the study of asymmetry factors shaping CPG bursting rhythms. In particular, we assess the role of asymmetric maximal synaptic conductances, time constants and gap-junction connectivity to establish the regularity of half-center oscillator based CPGs. We map and characterize the synaptic parameter space that lead to regular and irregular bursting activity in these networks. The analysis indicates that asymmetric configurations display robust regular rhythms and that large regions of both regular and irregular but coordinated rhythms exist as a function of the asymmetry in the circuit. Our results show that asymmetry both in the maximal conductances and in the temporal dynamics of mutually inhibitory neurons can synergistically contribute to shape wide regimes of regular spiking-bursting activity in CPGs. Finally, we discuss how a closed-loop protocol driven by a regularity goal can be used to find and characterize regular regimes when there is not time to perform an exhaustive search, as in most experimental studies. PMID:28261081

  4. SECONDARY LOW-LEVEL WASTE GENERATION RATE ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    D. LaRue

    1999-05-10

    The objective of this design analysis is -to update the assessment of estimated annual secondary low-level waste (LLW) generation rates resulting from the repackaging of spent nuclear fuel (SNF) and high-level waste (HLW) for disposal at the Monitored Geologic Repository (MGR). This analysis supports the preparation of documentation necessary for license application (LA) for the MGR. For the purposes of this analysis, secondary LLW is defined, in brief terms, as LLW generated as a direct result of processing SNF/HLW through the receiving and repackaging operations. The current Waste Handling Building (WHB) design is based on the predominant movement of fuel assemblies through the wet handling lines within the WHB. Dry handling lines are also included in the current WHB design to accommodate canistered waste (i.e., SNF and/or HLW packages). Major input changes to this analysis in comparison to previous analyses include: (1) changes in the SNF/HLW arrival schedules; (2) changes to the WHB and the Waste Treatment Building (WTB) dimensions; and (3) changes in operational staff sizes within the WHB and WTB. The rates generated in this analysis can be utilized to define necessary waste processes, waste flow rates, and equipment sizes for the processing of secondary LLW for proper disposal. This analysis is based on the present reference design, i.e., Viability Assessment (VA) design, and present projections on spent fuel delivery and processing. LLW generation rates, for both liquids and solids, are a direct function of square footages in radiological areas, and a direct function of spent fuel throughput. Future changes in the approved reference design or spent fuel throughput will directly impact the LLW generation rates defined in this analysis. Small amounts of wastes other than LLW may be generated on a non-routine basis. These wastes may include transuranic (TRU), hazardous, and mixed wastes. Although the objective of this analysis is to define LLW waste generation

  5. Analysis for damages of HPT bearings and generator blower

    Energy Technology Data Exchange (ETDEWEB)

    Gho, W. S.; Kim, G. Y.; Lee, W. G. [Korea Electric Power Research Institute, Taejon (Korea, Republic of)

    2003-10-01

    During normal operation of nuclear turbine-generator, we have found the gap volt increased on the HP turbine bearings. After a week, turbine-generator was tripped due to activating the mechanical overspeed trigger during coast down operation for refueling. On disassembling, we have found the HPT bearings melted and generator blower blades broken. Reviewing the operation and vibration data and damaged components, we have concluded 2{approx}3 blades were broken during transient operation, when generator was vented and filled with CO2 in short time after tripping of turbine-generator due to leaking hydrogen from generator 2 months ago. At this time, the surge or stall through generator blower made reverse force on the rotating blades and made 2{approx}3 blades broken. Blower blades were broken and damaged more during additional transient operation and made rotor current increased due to rubbing of damaged parts. The HPT bearings were corroded electrically and melted down by breaking minimum oil film during speed down operation. The analysis and actions were properly performed and made safe operation of nuclear turbine-generator.

  6. Identification of noise in linear data sets by factor analysis

    Energy Technology Data Exchange (ETDEWEB)

    Roscoe, B.A.; Hopke, P.K.

    1981-01-01

    The approach to classical factor analysis described in this paper, i.e. doing the analysis for varying numbers of factors without prior assumptions to the number of factors, prevents one from getting eroneous results by inherent computer code assumptions. Identification of a factor containing most of the variance of one variable with little variance of other variables, pinpoints a possible difficulty in the data, if the singularity has no obvious physical significance. Examination of the factor scores will determine whether the problem is isolated to a few samples or over all the samples. Having this information, one may then go back to the raw data and take the appropriate corrective action. Classical factor analysis has the ability to identify several types of errors in data after it has been generated. It is then ideally suited for scanning large data sets. The ease of the identification technique makes it a beneficial tool to use before reduction and analysis of large data sets and should, in the long run, save time and effort.

  7. Determining Dimensionality of Exercise Readiness Using Exploratory Factor Analysis.

    Science.gov (United States)

    Strohacker, Kelley; Zakrajsek, Rebecca A

    2016-06-01

    Assessment of "exercise readiness" is a central component to the flexible non-linear periodization (FNLP) method of organizing training workloads, but the underlying factor structure of this construct has not been empirically determined. The purpose of this study was to assess construct dimensionality of exercise readiness using exploratory factor analysis. The result of which serve as initial steps of developing a brief measure of exercise readiness. Participants consisted of students recruited from undergraduate Kinesiology courses at a racially diverse, southern University. Independent, anonymous online survey data were collected across three stages: 1) generation of item pool (n = 290), 2) assessment of face validity and refinement of item pool (n = 168), and 3) exploratory factor analysis (n = 684). A principal axis factor analysis was conducted with 41 items using oblique rotation (promax). Four statistically significant factors, as determined through parallel analysis, explained 61.5% of the variance in exercise readiness. Factor 1 contained items that represented vitality (e.g., lively, revived). Factor 2 items related to physical fatigue (e.g. tired, drained). Factors 3 and 4 were descriptive of, discomfort (e.g. pain, sick) and health (i.e. healthy, fit), respectively. This inductive approach indicates that exercise readiness is comprised of four dimensions: vitality, physical fatigue, discomfort, and health. This finding supports readiness assessment techniques currently recommended for practitioners according to the FNLP model. These results serve as a theoretical foundation upon which to further develop and refine a brief survey instrument to measure exercise readiness. Key pointsAssessment of exercise readiness is a key component in implementing an exercise program based on flexible nonlinear periodization, but the dimensionality of this concept has not been empirically determined.Based on a series of surveys and a robust exploratory factor analysis

  8. Analysis of Economic Factors Affecting Stock Market

    OpenAIRE

    Xie, Linyin

    2010-01-01

    This dissertation concentrates on analysis of economic factors affecting Chinese stock market through examining relationship between stock market index and economic factors. Six economic variables are examined: industrial production, money supply 1, money supply 2, exchange rate, long-term government bond yield and real estate total value. Stock market comprises fixed interest stocks and equities shares. In this dissertation, stock market is restricted to equity market. The stock price in thi...

  9. Generating function approach to reliability analysis of structural systems

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The generating function approach is an important tool for performance assessment in multi-state systems. Aiming at strength reliability analysis of structural systems, generating function approach is introduced and developed. Static reliability models of statically determinate, indeterminate systems and fatigue reliability models are built by constructing special generating functions, which are used to describe probability distributions of strength (resistance), stress (load) and fatigue life, by defining composite operators of generating functions and performance structure functions thereof. When composition operators are executed, computational costs can be reduced by a big margin by means of collecting like terms. The results of theoretical analysis and numerical simulation show that the generating function approach can be widely used for probability modeling of large complex systems with hierarchical structures due to the unified form, compact expression, computer program realizability and high universality. Because the new method considers twin loads giving rise to component failure dependency, it can provide a theoretical reference and act as a powerful tool for static, dynamic reliability analysis in civil engineering structures and mechanical equipment systems with multi-mode damage coupling.

  10. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.

    Science.gov (United States)

    Riechmann, J L; Heard, J; Martin, G; Reuber, L; Jiang, C; Keddie, J; Adam, L; Pineda, O; Ratcliffe, O J; Samaha, R R; Creelman, R; Pilgrim, M; Broun, P; Zhang, J Z; Ghandehari, D; Sherman, B K; Yu, G

    2000-12-15

    The completion of the Arabidopsis thaliana genome sequence allows a comparative analysis of transcriptional regulators across the three eukaryotic kingdoms. Arabidopsis dedicates over 5% of its genome to code for more than 1500 transcription factors, about 45% of which are from families specific to plants. Arabidopsis transcription factors that belong to families common to all eukaryotes do not share significant similarity with those of the other kingdoms beyond the conserved DNA binding domains, many of which have been arranged in combinations specific to each lineage. The genome-wide comparison reveals the evolutionary generation of diversity in the regulation of transcription.

  11. Horizontal steam generator PGV-1000 thermal-hydraulic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ubra, O. [Skoda Company, Prague (Switzerland); Doubek, M. [Czech Technical Univ., Prague (Switzerland)

    1995-12-31

    A computer program for the steady state thermal-hydraulic analysis of horizontal steam generator PGV-1000 is presented. The program provides the capability to analyze steam generator PGV-1000 primary side flow and temperature distribution, primary side pressure drops, heat transfer between the primary and secondary sides and multidimensional heat flux distribution. A special attention is paid to the thermal-hydraulics of the secondary side. The code predicts 3-D distribution of the void fraction at the secondary side, mass redistribution under the submerged perforated sheet and the steam generator level profile. By means of developed computer program a detailed thermal-hydraulic study of the PGV-1000 has been carried out. A wide range of calculations has been performed and a set of important steam generator characteristics has been obtained. Some of them are presented in the paper. (orig.). 5 refs.

  12. Determination of a synchronous generator characteristics via Finite Element Analysis

    Directory of Open Access Journals (Sweden)

    Kolondzovski Zlatko

    2005-01-01

    Full Text Available In the paper a determination of characteristics of a small salient pole synchronous generator (SG is presented. Machine characteristics are determined via Finite Element Analysis (FEA and for that purpose is used the software package FEMM Version 3.3. After performing their calculation and analysis, one can conclude that most of the characteristics presented in this paper can be obtained only by using the Finite Element Method (FEM.

  13. Synthetic Training Data Generation for Activity Monitoring and Behavior Analysis

    Science.gov (United States)

    Monekosso, Dorothy; Remagnino, Paolo

    This paper describes a data generator that produces synthetic data to simulate observations from an array of environment monitoring sensors. The overall goal of our work is to monitor the well-being of one occupant in a home. Sensors are embedded in a smart home to unobtrusively record environmental parameters. Based on the sensor observations, behavior analysis and modeling are performed. However behavior analysis and modeling require large data sets to be collected over long periods of time to achieve the level of accuracy expected. A data generator - was developed based on initial data i.e. data collected over periods lasting weeks to facilitate concurrent data collection and development of algorithms. The data generator is based on statistical inference techniques. Variation is introduced into the data using perturbation models.

  14. An Approach to Scenario Analysis, Generation and Evaluation

    NARCIS (Netherlands)

    Chen, Y.; Van Zuylen, H.J.

    2014-01-01

    This article presents an operation-oriented approach for traffic management scenario generation, analysis and evaluation. We start taking a few most applied scenarios from a traffic control centre, analysing each component and structure of the whole, and evaluating the impact of each component and s

  15. Validation of the French version of the marijuana craving questionnaire (MCQ) generates a two-factor model.

    Science.gov (United States)

    Chauchard, Emeline; Goutaudier, Nelly; Heishman, Stephen J; Gorelick, David A; Chabrol, Henri

    2015-01-01

    Craving is a major issue in drug addiction, and a target for drug treatment. The Marijuana Craving Questionnaire-Short Form (MCQ-SF) is a useful tool for assessing cannabis craving in clinical and research settings. To validate the French version of the MCQ-SF (FMCQ-SF). Young adult cannabis users not seeking treatment (n = 679) completed the FMCQ-SF and questionnaires assessing their frequency of cannabis use and craving, cannabis use disorder criteria, and alcohol use. Confirmatory factor analysis of the four-factor FMCQ-SF model did not fit the data well. Exploratory factor analysis suggested a two-factor solution ("pleasure", characterized by planning and expectation of positive effects, and "release of tension", characterized by relief from anxiety, nervousness, or tension) with good psychometric properties. This two-factor model showed good internal and convergent validity and correlated with cannabis abuse and dependence and with frequency of cannabis use and craving. Validation of the FMCQ-SF generated a two-factor model, different from the four-factor solution generated in English language studies. Considering that craving plays an important role in withdrawal and relapse, this questionnaire should be useful for French-language addiction professionals.

  16. Generation Y New Zealand Registered Nurses' views about nursing work: a survey of motivation and maintenance factors.

    Science.gov (United States)

    Jamieson, Isabel; Kirk, Ray; Wright, Sarah; Andrew, Cathy

    2015-07-01

    The aim of this article was to report on the analysis of qualitative, open text data, received from a national on-line survey of what factors Generation Y New Zealand Registered Nurses wish to change about nursing and consideration of the potential policy and practice impacts of these requests on their retention. Prior to the economic recession of 2007-2010, the growing shortage of nurses in New Zealand presented a serious concern for the healthcare workforce. Given the ageing New Zealand nursing workforce, an ageing population and the increasing demands for health care, it is imperative that issues of retention of Generation Y nurses are resolved prior to the imminent retirement of more experienced nurses. A descriptive exploratory approach using a national wide, on-line survey, eliciting both quantitative and qualitative data was used. The survey, conducted from August 2009-January 2010, collected data from Generation Y New Zealand Registered Nurses (n = 358) about their views about nursing, work and career. Herzberg's Motivation-Hygiene theory was used as the framework for the analysis of the open text data. The factors that nurses wanted changed were skewed towards Herzberg's hygiene-maintenance factors rather than motivating factors. This is of concern because hygiene-maintenance factors are considered to be dissatisfiers that are likely to push workers to another employment option.

  17. Estimation of fouling factors in the design of steam generators; Estimacion de factores de ensuciamiento en el diseno de generadores de vapor

    Energy Technology Data Exchange (ETDEWEB)

    Flores Archila, David Ivanhoe

    1997-12-31

    This thesis proposes an alternative to correct design problems the evaluation of fouling factors of thermal energy transfer components of a power station generator. That alternative involves the development of a subroutine to apply fundamental empirical thermal transfer correlations, written in FORTRAN language and extends a principal program for steam generator thermal analysis, developed by Instituto de Investigaciones Electricas. [Espanol] Esta tesis propone una alternativa, basada en el calculo de factores de ensuciamiento de elementos de transferencia de energia termica de un generador de vapor, como mecanismo para corregir el diseno deficiente de areas de calefaccion. Esta alternativa involucra el desarrollo de una subrutina, escrita en FORTRAN, la cual realiza el calculo de los factores de ensuciamiento empleando correlaciones fundamentadas en la teoria de los procesos de transferencia de calor y forma parte de un programa principal para el analisis termico de generadores de vapor desarrollado en el Instituto de Investigaciones Electricas.

  18. The carrier-generating analysis of MEMS gyroscope interface circuit

    Directory of Open Access Journals (Sweden)

    GuangMin Yuan

    2014-03-01

    Full Text Available In this paper, the main factors which influence the noise ratio of gyroscope output signal were analysed, according to the MEMS gyro interface circuit technology. A working principle of a carrier in the gyroscope circuit was discussed, the process formula of the carrier amplitude and frequency in the interface circuit of modulation and demodulation was deduced, and the error components lead-in from carrier to gyroscope circuit was distinguished. Several commonly used carrier-generating circuit schemes were analysed and compared, and a carrier-generating program in the interface circuits of the micro-gyroscope was designed, which was applied in a MEMS gyro developed by our laboratory. The measurement results show that the amplitude stability and frequency stability is 1.3 ppm and 12 ppm, respectively, meeting the performance requirements of carrier generating in the MEMS gyro circuit.

  19. The carrier-generating analysis of MEMS gyroscope interface circuit

    Science.gov (United States)

    Yuan, GuangMin; Yuan, Weizheng; Zhu, Xiaobo; Chang, HongLong

    2014-03-01

    In this paper, the main factors which influence the noise ratio of gyroscope output signal were analysed, according to the MEMS gyro interface circuit technology. A working principle of a carrier in the gyroscope circuit was discussed, the process formula of the carrier amplitude and frequency in the interface circuit of modulation and demodulation was deduced, and the error components lead-in from carrier to gyroscope circuit was distinguished. Several commonly used carrier-generating circuit schemes were analysed and compared, and a carrier-generating program in the interface circuits of the micro-gyroscope was designed, which was applied in a MEMS gyro developed by our laboratory. The measurement results show that the amplitude stability and frequency stability is 1.3 ppm and 12 ppm, respectively, meeting the performance requirements of carrier generating in the MEMS gyro circuit.

  20. What Is Rotating in Exploratory Factor Analysis?

    Science.gov (United States)

    Osborne, Jason W.

    2015-01-01

    Exploratory factor analysis (EFA) is one of the most commonly-reported quantitative methodology in the social sciences, yet much of the detail regarding what happens during an EFA remains unclear. The goal of this brief technical note is to explore what "rotation" is, what exactly is rotating, and why we use rotation when performing…

  1. Stepwise Variable Selection in Factor Analysis.

    Science.gov (United States)

    Kano, Yutaka; Harada, Akira

    2000-01-01

    Takes several goodness-of-fit statistics as measures of variable selection and develops backward elimination and forward selection procedures in exploratory factor analysis. A newly developed variable selection program, SEFA, can print several fit measures for a current model and models obtained by removing an internal variable or adding an…

  2. Multilevel exploratory factor analysis of discrete data

    NARCIS (Netherlands)

    Barendse, M.T.; Oort, F.J.; Jak, S.; Timmerman, M.E.

    2013-01-01

    Exploratory factor analysis (EFA) can be used to determine the dimensionality of a set of items. When data come from clustered subjects, such as pupils within schools or children within families, the hierarchical structure of the data should be taken into account. Standard multilevel EFA is only sui

  3. An SPSSR -Menu for Ordinal Factor Analysis

    Directory of Open Access Journals (Sweden)

    Mario Basto

    2012-01-01

    Full Text Available Exploratory factor analysis is a widely used statistical technique in the social sciences. It attempts to identify underlying factors that explain the pattern of correlations within a set of observed variables. A statistical software package is needed to perform the calculations. However, there are some limitations with popular statistical software packages, like SPSS. The R programming language is a free software package for statistical and graphical computing. It offers many packages written by contributors from all over the world and programming resources that allow it to overcome the dialog limitations of SPSS. This paper offers an SPSS dialog written in theR programming language with the help of some packages, so that researchers with little or no knowledge in programming, or those who are accustomed to making their calculations based on statistical dialogs, have more options when applying factor analysis to their data and hence can adopt a better approach when dealing with ordinal, Likert-type data.

  4. Beam Propagation Factor and Generation of Cosh-squared-Gaussian Beams

    Institute of Scientific and Technical Information of China (English)

    ZHU Kaicheng; TANG Huiqin; ZHU Zhenhe

    2001-01-01

    A new light beam termed as a cosh-squared-Gaussian beam (ChSGB) which may be one of solutions of the paraxial wave equation for propagation in complex optical systems has been introduced. Their beam propagation factor (M2-factor) is derived and schemes to generate this light beams are proposed.

  5. Assessing computer waste generation in Chile using material flow analysis.

    Science.gov (United States)

    Steubing, Bernhard; Böni, Heinz; Schluep, Mathias; Silva, Uca; Ludwig, Christian

    2010-03-01

    The quantities of e-waste are expected to increase sharply in Chile. The purpose of this paper is to provide a quantitative data basis on generated e-waste quantities. A material flow analysis was carried out assessing the generation of e-waste from computer equipment (desktop and laptop PCs as well as CRT and LCD-monitors). Import and sales data were collected from the Chilean Customs database as well as from publications by the International Data Corporation. A survey was conducted to determine consumers' choices with respect to storage, re-use and disposal of computer equipment. The generation of e-waste was assessed in a baseline as well as upper and lower scenarios until 2020. The results for the baseline scenario show that about 10,000 and 20,000 tons of computer waste may be generated in the years 2010 and 2020, respectively. The cumulative e-waste generation will be four to five times higher in the upcoming decade (2010-2019) than during the current decade (2000-2009). By 2020, the shares of LCD-monitors and laptops will increase more rapidly replacing other e-waste including the CRT-monitors. The model also shows the principal flows of computer equipment from production and sale to recycling and disposal. The re-use of computer equipment plays an important role in Chile. An appropriate recycling scheme will have to be introduced to provide adequate solutions for the growing rate of e-waste generation.

  6. ANALYSIS OF INTERNALLY GENERATED NOISE OF BIOELECTRIC AMPLIFIERS

    Institute of Scientific and Technical Information of China (English)

    MashhourMustafaBaniAmer

    2003-01-01

    This papenr deals with internally generated noise of bioelectric amplifiers that are usually used for processing of bioelectric events.The main purpose of this paper is to present a procedure for analysis of the effects of internal noise generated by the active circuits and to evaluate the output noise of the author's new designed bioelectric amplifier that caused by internal effects to the amplifier circuit itself in order to compare it with the noise generated by conventional amplifiers.The obtained analysis results of internally generated noise showed that the total output noise of bioelectric active circuits does not increase when some of their resitors have a larger value.This behavior is caused by the different transfer functions for the signal and the respective noise sources associated with these resistors.Moreover,the new designed bioelectric amplifier haws an output noise less than that for conventional amplifiers.The obtained analysis results were also experimentally verified and the final conclusions were drawn.

  7. Factors Contributing to the Waste Generation in Building Projects of Pakistan

    Directory of Open Access Journals (Sweden)

    Nafees Ahmed Memon

    2016-01-01

    Full Text Available Generation of construction waste is a worldwide issue that concerns not only governments but also the building actors involved in construction industry. For developing countries like Pakistan, rising levels of waste generation, due to the rapid growth of towns and cities have become critical issue. Therefore this study is aimed to detect the factors, which are the main causes of construction waste generation. Questionnaire survey has been conducted to achieve this task and RIW (Relative Importance Weight method has been used to analyze the results of this study. The important factors contributing to the generation of construction as identified in this study are: frequent changes/ revision in design during construction process; poor scheduling; unavailability of storage; poor workmanship; poor layout; inefficient planning and scheduling of resources and lack of coordination among supervision staff deployed at site. Based on the identified factors, the study also has presented some suggestions for the reduction of construction waste in building construction projects of Pakistan.

  8. Analysis and Design of Hybrid Excitation Permanent Magnet Synchronous Generators

    Institute of Scientific and Technical Information of China (English)

    JIN Wan-bing; ZHANG Dong; AN Zhong-liang; TAN Ren-yuan

    2006-01-01

    On the basis of a conventional permanent magnet (PM) synchronous generator's construction,a novel kind of Hybrid Excitation Permanent Magnet Synchronous Generator (HEPMSG) is introduced by inserting exciting winding in the stator or rotor.Firstly,the construction of HEPMSG is improved with the addition of PM excitation on the ferromagnetic pole,and its working principle and design method are studied in detail.Then,an appropriate exciting current control system is presented considering the characteristics of HEPMSG.Finally,a prototype is made,and test results confirm the analysis and design.

  9. Spatio-temporal analysis of regional PV generation

    DEFF Research Database (Denmark)

    Nuño Martinez, Edgar; Cutululis, Nicolaos Antonio

    2016-01-01

    Photovoltaic (PV) power is growing in importance worldwide and hence needs to be represented in operation and planning of power system. As opposed to traditional generation technologies, it is characterized by exhibiting both a high variability and a significant spatial dependence. This paper...... presents a fundamental analysis of regional solar generation time series, aiming to potentially facilitate large-scale solar integration. It will focus on characterizing the underlying dependence structure at the system level as well as describing both statistical and temporal properties of regional PV...

  10. Generating an Arabic Calligraphy Text Blocks for Global Texture Analysis

    Directory of Open Access Journals (Sweden)

    Bilal Bataineh

    2011-01-01

    Full Text Available This paper objective is to improve the current method for generating an Arabic Calligraphy text blocks. We test on seven types of Arabic Calligraphy text. We apply  projection profiles and a proposed filter to discriminate each line of the Arabic Calligraphy scripts. After performing text detection, skew correction, text and line normalization subsequently, we generate Arabic Calligraphy text blocks for global texture analysis purposes. We compare our proposed filter with current method and median filter. The results show that the proposed filter  is outperformed. The proposed method can be further  improved to boost the overall performance.

  11. ANALYSIS OF THE FACTORS AFFECTING THE AVERAGE

    Directory of Open Access Journals (Sweden)

    Carmen BOGHEAN

    2013-12-01

    Full Text Available Productivity in agriculture most relevantly and concisely expresses the economic efficiency of using the factors of production. Labour productivity is affected by a considerable number of variables (including the relationship system and interdependence between factors, which differ in each economic sector and influence it, giving rise to a series of technical, economic and organizational idiosyncrasies. The purpose of this paper is to analyse the underlying factors of the average work productivity in agriculture, forestry and fishing. The analysis will take into account the data concerning the economically active population and the gross added value in agriculture, forestry and fishing in Romania during 2008-2011. The distribution of the average work productivity per factors affecting it is conducted by means of the u-substitution method.

  12. Performance of Generating Plant: Managing the Changes. Part 2: Thermal Generating Plant Unavailability Factors and Availability Statistics

    Energy Technology Data Exchange (ETDEWEB)

    Curley, G. Michael [North American Electric Reliability Corporation (United States); Mandula, Jiri [International Atomic Energy Agency (IAEA)

    2008-05-15

    The WEC Committee on the Performance of Generating Plant (PGP) has been collecting and analysing power plant performance statistics worldwide for more than 30 years and has produced regular reports, which include examples of advanced techniques and methods for improving power plant performance through benchmarking. A series of reports from the various working groups was issued in 2008. This reference presents the results of Working Group 2 (WG2). WG2's main task is to facilitate the collection and input on an annual basis of power plant performance data (unit-by-unit and aggregated data) into the WEC PGP database. The statistics will be collected for steam, nuclear, gas turbine and combined cycle, hydro and pump storage plant. WG2 will also oversee the ongoing development of the availability statistics database, including the contents, the required software, security issues and other important information. The report is divided into two sections: Thermal generating, combined cycle/co-generation, combustion turbine, hydro and pumped storage unavailability factors and availability statistics; and nuclear power generating units.

  13. Study the effect of the organizational factors on the acceptance using combined heat and power Generation plants (small-scale generation by organizational Consumers

    Directory of Open Access Journals (Sweden)

    Mehdi Momeni

    2012-01-01

    Full Text Available The main goal of this research is to study the influence of organizational factors on the acceptance of using combined heat and power generation plants by organizational consumers. Organizational factors include the seven variables of organizational values, perception, organization representatives, organizational goals and tasks, organization, technology, organizational structure and organizational resources. Research method is typically descriptive-survey and applied based. Questionnaire has been used for data collection. The questionnaire has been developed based on theoretical principles and six points Likert spectrum. Content validity of questionnaires has been positively approved by scholars and experts. Data reliability has been computed using Cronbach’s alpha coefficient as 0.955, which is satisfactory. Descriptive and inferential statistics (correlation analysis, regression and T-test have been used for data analysis. Findings imply that i all of the above-mentioned variables influence the acceptance of power plants CHP (small-scale generation by the organizational consumers, significantly; and ii the order of importance and influence of organizational factors include organizational resources, organizational goals and tasks, perception, organization representatives, technology, organizational values, and organizational structure, respectively.

  14. A Review of Factors Influencing the Cost Development of Electricity Generation Technologies

    Directory of Open Access Journals (Sweden)

    Sascha Samadi

    2016-11-01

    Full Text Available This article reviews the literature on the past cost dynamics of various renewable, fossil fuel and nuclear electricity generation technologies. It identifies 10 different factors which have played key roles in influencing past cost developments according to the literature. These 10 factors are: deployment-induced learning, research, development and demonstration (RD&D-induced learning, knowledge spillovers from other technologies, upsizing, economies of manufacturing scale, economies of project scale, changes in material and labour costs, changes in fuel costs, regulatory changes, and limits to the availability of suitable sites. The article summarises the relevant literature findings for each of these 10 factors and provides an overview indicating which factors have impacted on which generation technologies. The article also discusses the insights gained from the review for a better understanding of possible future cost developments of electricity generation technologies. Finally, future research needs, which may support a better understanding of past and future cost developments, are identified.

  15. Analysis of the New Generation of Migrant Workers’ Urban Social Identification and Its Influence Factors%新生代农民工城市社会认同及影响因素探析

    Institute of Scientific and Technical Information of China (English)

    滕丽娟; 徐佩文

    2015-01-01

    从市民化要求出发考量,新生代农民工在身份认同、地域认同、文化认同、地位认同等方面存在诸多不乐观的情况。必须认清制度、社会、文化、地位等因素对新生代农民工城市社会认同的影响,增强新生代农民工对城市的社会认同度。%In terms of requirements for a citizen,the new generation of migrant workers has issues with identification,regional identification,cultural identification,status identification,etc.We should un-derstand the influence of system,society,culture and status,etc.on migrant workers’urban identifica-tion,thus enhancing migrant workers’identification of urban society.

  16. Generation Y New Zealand Registered Nurses’ views about nursing work: a survey of motivation and maintenance factors

    OpenAIRE

    Jamieson, Isabel; Kirk, Ray; Wright, Sarah; Andrew, Cathy

    2015-01-01

    Abstract Aim The aim of this article was to report on the analysis of qualitative, open text data, received from a national on‐line survey of what factors Generation Y New Zealand Registered Nurses wish to change about nursing and consideration of the potential policy and practice impacts of these requests on their retention. Background Prior to the economic recession of 2007–2010, the growing shortage of nurses in New Zealand presented a serious concern for the healthcare workforce. Given th...

  17. Non Parametric Statistical Analysis Research on College Students' Math Anxiety Generation Factors%大学生数学焦虑产生因素的非参数统计分析

    Institute of Scientific and Technical Information of China (English)

    范大付; 李春红

    2012-01-01

    The non-parametric statistics is a test method which does not involve the general parameter and does not depend on the distribution. By using the non-parametric statistics for analyzing and researching the factors of college students' math anxiety, we try to solve the negative effect for studying from math anxiety, and increase the academic achievement of the college students.%采用非参数统计方法中的Wilconxon秩和检验、Friedman检验、Mann-WhitneyU检验对大学生数学焦虑的5个主要影响因素进行了定量分析与评价,获得了数学焦虑产生因素的相关非参数统计结果,为解决数学焦虑所带来的学习负效应提供参考。

  18. Analysis of flow instabilities in forced-convection steam generator

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Because of the practical importance of two-phase instabilities, substantial efforts have been made to date to understand the physical phenomena governing such instabilities and to develop computational tools to model the dynamics. The purpose of this study is to present a numerical model for the analysis of flow-induced instabilities in forced-convection steam generator. The model is based on the assumption of homogeneous two-phase flow and thermodynamic equilibrium of the phases. The thermal capacity of the heater wall has been included in the analysis. The model is used to analyze the flow instabilities in the steam generator and to study the effects of system pressure, mass flux, inlet temperature and inlet/outlet restriction, gap size, the ratio of do /di, and the ratio of qi/qo on the system behavior.

  19. Factors affecting the retention of Generation X public servants: An exploratory study

    Directory of Open Access Journals (Sweden)

    Vhutshilo Masibigiri

    2011-02-01

    Full Text Available Orientation: Retaining employees, especially Generation Xers, is imperative to ensure the high performance of organisations.Purpose: The purpose of this study was to explore the factors that affect the retention of Generation X public servants.Motivation for the study: Given their unique characteristics, it is a challenge to retain Generation X employees. This problem may be worse in the public sector than in the private sector, as there are fewer financial rewards in the public service than in the private sector.Research design: The interpretivist paradigm is appropriate for this study. It used a qualitative, empirical approach. The researchers obtained the data through purposive sampling and interviews.Main findings: The study showed that the factors affecting the retention of Generation X public servants include work content, utilisation of skills, career advancement, work–life balance, compensation, security needs, leadership and drive.Practical/managerial implications: Employers, like the civil service, can be proactive in retaining Generation X employees because of the factors that affect their retention. Managers can prevent further pressure on service delivery that the skills shortage has caused if they use the skills the employees already have.Contribution: The article fills a gap, as there has been little research on staff retention. This is particularly true of Generation X employees in South Africa. This article adds information that will improve retention strategies for Generation X employees, particularly in the public service.

  20. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation.

    LENUS (Irish Health Repository)

    Ni Ainle, Fionnuala

    2009-08-20

    Protamine sulfate is a positively charged polypeptide widely used to reverse heparin-induced anticoagulation. Paradoxically, prospective randomized trials have shown that protamine administration for heparin neutralization is associated with increased bleeding, particularly after cardiothoracic surgery with cardiopulmonary bypass. The molecular mechanism(s) through which protamine mediates this anticoagulant effect has not been defined. In vivo administration of pharmacologic doses of protamine to BALB\\/c mice significantly reduced plasma thrombin generation and prolonged tail-bleeding time (from 120 to 199 seconds). Similarly, in pooled normal human plasma, protamine caused significant dose-dependent prolongations of both prothrombin time and activated partial thromboplastin time. Protamine also markedly attenuated tissue factor-initiated thrombin generation in human plasma, causing a significant decrease in endogenous thrombin potential (41% +\\/- 7%). As expected, low-dose protamine effectively reversed the anticoagulant activity of unfractionated heparin in plasma. However, elevated protamine concentrations were associated with progressive dose-dependent reduction in thrombin generation. To assess the mechanism by which protamine mediates down-regulation of thrombin generation, the effect of protamine on factor V activation was assessed. Protamine was found to significantly reduce the rate of factor V activation by both thrombin and factor Xa. Protamine mediates its anticoagulant activity in plasma by down-regulation of thrombin generation via a novel mechanism, specifically inhibition of factor V activation.

  1. The Effects of Overextraction on Factor and Component Analysis.

    Science.gov (United States)

    Fava, J L; Velicer, W F

    1992-07-01

    The effects of overextracting factors and components within and between the methods of maximum likelihood factor analysis (MLFA) and principal component analysis (PCA) were examined. Computer-simulated data sets were generated to represent a range of factor and component patterns. Saturation (aij = .8, .6 & .4), sample size (N = 75, 150,225,450), and variable-to-component (factor) ratio (p:m = 12:1,6:1, & 4:1) were conditions manipulated. In Study 1, scores based on the incorrect patterns were correlated with correct scores within each method after each overextraction. In Study 2, scores were correlated between the methods of PCAand MLFA after each overextraction. Overextraction had a negative effect, but scores based on strong component and factor patterns displayed robustness to the effects of overextraction. Low item saturation and low sample size resulted in degraded score reproduction. Degradation was strongest for patterns that combined low saturation and low sample size. Component and factor scores were highly correlated even at maximal levels of overextraction. Dissimilarity between score methods was the greatest in conditions that combined low saturation and low sample size. Some guidelines for researchers concerning the effects of overextraction are noted, as well as some cautions in the interpretation of results.

  2. Nominal Performance Biosphere Dose Conversion Factor Analysis

    Energy Technology Data Exchange (ETDEWEB)

    M.A. Wasiolek

    2005-04-28

    This analysis report is one of the technical reports containing documentation of the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the Total System Performance Assessment (TSPA) for the license application (LA) for the Yucca Mountain repository. This analysis report describes the development of biosphere dose conversion factors (BDCFs) for the groundwater exposure scenario, and the development of conversion factors for assessing compliance with the groundwater protection standards. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1-1. This figure shows the interrelationships among the products (i.e., analysis and model reports) developed for biosphere modeling and provides an understanding of how this analysis report contributes to biosphere modeling. This report is one of two reports that develop BDCFs, which are input parameters for the TSPA-LA model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes in detail the ERMYN conceptual model and mathematical model. The input parameter reports, shown to the right of the ''Biosphere Model Report'' in Figure 1-1, contain detailed description of the model input parameters, their development, and the relationship between the parameters and specific features events and processes (FEPs). This report describes biosphere model calculations and their output, the BDCFs, for the groundwater exposure scenario. This analysis receives direct input from the outputs of the ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) and the five analyses that develop parameter values for the biosphere model (BSC 2005 [DIRS 172827]; BSC 2004 [DIRS 169672]; BSC 2004 [DIRS 169673]; BSC 2004 [DIRS 169458]; BSC 2004 [DIRS 169459]). The results of this report are further analyzed in the ''Biosphere Dose Conversion Factor Importance and Sensitivity Analysis

  3. A kernel version of spatial factor analysis

    DEFF Research Database (Denmark)

    Nielsen, Allan Aasbjerg

    2009-01-01

    . Schölkopf et al. introduce kernel PCA. Shawe-Taylor and Cristianini is an excellent reference for kernel methods in general. Bishop and Press et al. describe kernel methods among many other subjects. Nielsen and Canty use kernel PCA to detect change in univariate airborne digital camera images. The kernel...... version of PCA handles nonlinearities by implicitly transforming data into high (even infinite) dimensional feature space via the kernel function and then performing a linear analysis in that space. In this paper we shall apply kernel versions of PCA, maximum autocorrelation factor (MAF) analysis...

  4. Porphyromonas gingivalis Uses Specific Domain Rearrangements and Allelic Exchange to Generate Diversity in Surface Virulence Factors

    Science.gov (United States)

    Dashper, Stuart G.; Mitchell, Helen L.; Seers, Christine A.; Gladman, Simon L.; Seemann, Torsten; Bulach, Dieter M.; Chandry, P. Scott; Cross, Keith J.; Cleal, Steven M.; Reynolds, Eric C.

    2017-01-01

    Porphyromonas gingivalis is a keystone pathogen of chronic periodontitis. The virulence of P. gingivalis is reported to be strain related and there are currently a number of strain typing schemes based on variation in capsular polysaccharide, the major and minor fimbriae and adhesin domains of Lys-gingipain (Kgp), amongst other surface proteins. P. gingivalis can exchange chromosomal DNA between strains by natural competence and conjugation. The aim of this study was to determine the genetic variability of P. gingivalis strains sourced from international locations over a 25-year period and to determine if variability in surface virulence factors has a phylogenetic basis. Whole genome sequencing was performed on 13 strains and comparison made to 10 previously sequenced strains. A single nucleotide polymorphism-based phylogenetic analysis demonstrated a shallow tri-lobed phylogeny. There was a high level of reticulation in the phylogenetic network, demonstrating extensive horizontal gene transfer between the strains. Two highly conserved variants of the catalytic domain of the major virulence factor the Kgp proteinase (KgpcatI and KgpcatII) were found. There were three variants of the fourth Kgp C-terminal cleaved adhesin domain. Specific variants of the cell surface proteins FimA, FimCDE, MfaI, RagAB, Tpr, and PrtT were also identified. The occurrence of all these variants in the P. gingivalis strains formed a mosaic that was not related to the SNP-based phylogeny. In conclusion P. gingivalis uses domain rearrangements and genetic exchange to generate diversity in specific surface virulence factors. PMID:28184216

  5. What Is Rotating in Exploratory Factor Analysis?

    Directory of Open Access Journals (Sweden)

    Jason W. Osborne

    2015-01-01

    Full Text Available Exploratory factor analysis (EFA is one of the most commonly-reported quantitative methodology in the social sciences, yet much of the detail regarding what happens during an EFA remains unclear. The goal of this brief technical note is to explore what - rotation- is, what exactly is rotating, and why we use rotation when performing EFAs. Some commentary about the relative utility and desirability of different rotation methods concludes the narrative.

  6. Factors Associated With Electronic Cigarette Users’ Device Preferences and Transition From First Generation to Advanced Generation Devices

    Science.gov (United States)

    Veldheer, Susan; Hrabovsky, Shari; Nichols, Travis T.; Wilson, Stephen J.; Foulds, Jonathan

    2015-01-01

    Introduction: Electronic cigarettes (e-cigs) are becoming increasingly popular but little is known about how e-cig users’ transition between the different device types and what device characteristics and preferences may influence the transition. Methods: Four thousand four hundred twenty-one experienced e-cig users completed an online survey about their e-cig use, devices, and preferences. Participants included in analysis were ever cigarette smokers who used an e-cig at least 30 days in their lifetime and who reported the type of their first and current e-cig device and the nicotine concentration of their liquid. Analyses focused on transitions between “first generation” devices (same size as a cigarette with no button) and “advanced generation” devices (larger than a cigarette with a manual button) and differences between current users of each device type. Results: Most e-cig users (n = 2603, 58.9%) began use with a first generation device, and of these users, 63.7% subsequently transitioned to current use of an advanced generation device. Among users who began use with an advanced generation device (n = 1818, 41.1%), only 5.7% transitioned to a first generation device. Seventy-seven percent of current advanced generation e-cig users switched to their current device in order to obtain a “more satisfying hit.” Battery capabilities and liquid flavor choices also influenced device choice. Conclusion: E-cig users commonly begin use with a device shaped like a cigarette and transition to a larger device with a more powerful battery, a button for manual activation and a wider choice of liquid flavors. PMID:25744966

  7. Power generation using sugar cane bagasse: A heat recovery analysis

    Science.gov (United States)

    Seguro, Jean Vittorio

    The sugar industry is facing the need to improve its performance by increasing efficiency and developing profitable by-products. An important possibility is the production of electrical power for sale. Co-generation has been practiced in the sugar industry for a long time in a very inefficient way with the main purpose of getting rid of the bagasse. The goal of this research was to develop a software tool that could be used to improve the way that bagasse is used to generate power. Special focus was given to the heat recovery components of the co-generation plant (economizer, air pre-heater and bagasse dryer) to determine if one, or a combination, of them led to a more efficient co-generation cycle. An extensive review of the state of the art of power generation in the sugar industry was conducted and is summarized in this dissertation. Based on this models were developed. After testing the models and comparing the results with the data collected from the literature, a software application that integrated all these models was developed to simulate the complete co-generation plant. Seven different cycles, three different pressures, and sixty-eight distributions of the flue gas through the heat recovery components can be simulated. The software includes an economic analysis tool that can help the designer determine the economic feasibility of different options. Results from running the simulation are presented that demonstrate its effectiveness in evaluating and comparing the different heat recovery components and power generation cycles. These results indicate that the economizer is the most beneficial option for heat recovery and that the use of waste heat in a bagasse dryer is the least desirable option. Quantitative comparisons of several possible cycle options with the widely-used traditional back-pressure turbine cycle are given. These indicate that a double extraction condensing cycle is best for co-generation purposes. Power generation gains between 40 and

  8. A Beginner’s Guide to Factor Analysis: Focusing on Exploratory Factor Analysis

    Directory of Open Access Journals (Sweden)

    An Gie Yong

    2013-10-01

    Full Text Available The following paper discusses exploratory factor analysis and gives an overview of the statistical technique and how it is used in various research designs and applications. A basic outline of how the technique works and its criteria, including its main assumptions are discussed as well as when it should be used. Mathematical theories are explored to enlighten students on how exploratory factor analysis works, an example of how to run an exploratory factor analysis on SPSS is given, and finally a section on how to write up the results is provided. This will allow readers to develop a better understanding of when to employ factor analysis and how to interpret the tables and graphs in the output.

  9. Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events.

    Directory of Open Access Journals (Sweden)

    Rinske Loeffen

    Full Text Available In acute coronary syndrome (ACS cardiac cell damage is preceded by thrombosis. Therefore, plasma coagulation markers may have additional diagnostic relevance in ACS. By using novel coagulation assays this study aims to gain more insight into the relationship between the coagulation system and ACS.We measured plasma thrombin generation, factor XIa and D-dimer levels in plasma from ACS (n = 104 and non-ACS patients (n = 42. Follow-up measurements (n = 73 were performed at 1 and 6 months. Associations between coagulation markers and recurrent cardiovascular events were calculated by logistic regression analysis.Thrombin generation was significantly enhanced in ACS compared to non-ACS patients: peak height 148±53 vs. 122±42 nM. There was a significantly diminished ETP reduction (32 vs. 41% and increased intrinsic coagulation activation (25 vs. 7% in ACS compared to non-ACS patients. Furthermore, compared to non-ACS patients factor XIa and D-dimer levels were significantly elevated in ACS patients: 1.9±1.1 vs. 1.4±0.7 pM and 495(310-885 vs. 380(235-540 μg/L. Within the ACS spectrum, ST-elevated myocardial infarction patients had the highest prothrombotic profile. During the acute event, thrombin generation was significantly increased compared to 1 and 6 months afterwards: peak height 145±52 vs. 100±44 vs. 98±33 nM. Both peak height and factor XIa levels on admission predicted recurrent cardiovascular events (OR: 4.9 [95%CI 1.2-20.9] and 4.5 [1.1-18.9].ACS patients had an enhanced prothrombotic profile, demonstrated by an increased thrombin generation potential, factor XIa and D-dimer levels. This study is the first to demonstrate the positive association between factor XIa, thrombin generation and recurrent cardiovascular events.

  10. Factor XIa and Thrombin Generation Are Elevated in Patients with Acute Coronary Syndrome and Predict Recurrent Cardiovascular Events

    Science.gov (United States)

    Loeffen, Rinske; van Oerle, René; Leers, Mathie P. G.; Kragten, Johannes A.; Crijns, Harry; Spronk, Henri M. H.; ten Cate, Hugo

    2016-01-01

    Objective In acute coronary syndrome (ACS) cardiac cell damage is preceded by thrombosis. Therefore, plasma coagulation markers may have additional diagnostic relevance in ACS. By using novel coagulation assays this study aims to gain more insight into the relationship between the coagulation system and ACS. Methods We measured plasma thrombin generation, factor XIa and D-dimer levels in plasma from ACS (n = 104) and non-ACS patients (n = 42). Follow-up measurements (n = 73) were performed at 1 and 6 months. Associations between coagulation markers and recurrent cardiovascular events were calculated by logistic regression analysis. Results Thrombin generation was significantly enhanced in ACS compared to non-ACS patients: peak height 148±53 vs. 122±42 nM. There was a significantly diminished ETP reduction (32 vs. 41%) and increased intrinsic coagulation activation (25 vs. 7%) in ACS compared to non-ACS patients. Furthermore, compared to non-ACS patients factor XIa and D-dimer levels were significantly elevated in ACS patients: 1.9±1.1 vs. 1.4±0.7 pM and 495(310–885) vs. 380(235–540) μg/L. Within the ACS spectrum, ST-elevated myocardial infarction patients had the highest prothrombotic profile. During the acute event, thrombin generation was significantly increased compared to 1 and 6 months afterwards: peak height 145±52 vs. 100±44 vs. 98±33 nM. Both peak height and factor XIa levels on admission predicted recurrent cardiovascular events (OR: 4.9 [95%CI 1.2–20.9] and 4.5 [1.1–18.9]). Conclusion ACS patients had an enhanced prothrombotic profile, demonstrated by an increased thrombin generation potential, factor XIa and D-dimer levels. This study is the first to demonstrate the positive association between factor XIa, thrombin generation and recurrent cardiovascular events. PMID:27419389

  11. Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation

    Science.gov (United States)

    Stopa, Jack D.; Neuberg, Donna; Puligandla, Maneka; Furie, Bruce; Zwicker, Jeffrey I.

    2017-01-01

    BACKGROUND: Protein disulfide isomerase (PDI) is required for thrombus formation. We previously demonstrated that glycosylated quercetin flavonoids such as isoquercetin inhibit PDI activity and thrombus formation in animal models, but whether extracellular PDI represents a viable anticoagulant target in humans and how its inhibition affects blood coagulation remain unknown. METHODS: We evaluated effects of oral administration of isoquercetin on platelet-dependent thrombin generation in healthy subjects and patients with persistently elevated anti-phospholipid antibodies. RESULTS: Following oral administration of 1,000 mg isoquercetin to healthy adults, the measured peak plasma quercetin concentration (9.2 μM) exceeded its IC50 for inhibition of PDI by isoquercetin in vitro (2.5 ± 0.4 μM). Platelet-dependent thrombin generation decreased by 51% in the healthy volunteers compared with baseline (P = 0.0004) and by 64% in the anti-phospholipid antibody cohort (P = 0.015) following isoquercetin ingestion. To understand how PDI affects thrombin generation, we evaluated substrates of PDI identified using an unbiased mechanistic-based substrate trapping approach. These studies identified platelet factor V as a PDI substrate. Isoquercetin blocked both platelet factor Va and thrombin generation with an IC50 of ~5 μM. Inhibition of PDI by isoquercetin ingestion resulted in a 53% decrease in the generation of platelet factor Va (P = 0.001). Isoquercetin-mediated inhibition was reversed with addition of exogenous factor Va. CONCLUSION: These studies show that oral administration of isoquercetin inhibits PDI activity in plasma and diminishes platelet-dependent thrombin generation predominantly by blocking the generation of platelet factor Va. These pharmacodynamic and mechanistic observations represent an important step in the development of a novel class of antithrombotic agents targeting PDI. TRIAL REGISTRATION: Clinicaltrials.gov (NCT01722669) FUNDING: National Heart

  12. Factor analysis identifies subgroups of constipation

    Institute of Scientific and Technical Information of China (English)

    Philip G Dinning; Mike Jones; Linda Hunt; Sergio E Fuentealba; Jamshid Kalanter; Denis W King; David Z Lubowski; Nicholas J Talley; Ian J Cook

    2011-01-01

    AIM: To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction. METHODS: One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item, wide-ranging selfreport questionnaire. One hundred of these patients had colonic transit measured scintigraphically. Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology. Cluster analysis was used to determine whether individual patients naturally group into distinct subtypes. RESULTS: Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors. Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit, irritable bowel syndrome positive criteria and regular stool frequency. The majority of patients with these characteristics also reported regular laxative use. CONCLUSION: Factor analysis identified four constipation subgroups, based on severity and laxative unresponsiveness, in a constipated population. However, clear stratification into clinically identifiable groups remains imprecise.

  13. Analysis of public consciousness structure and consideration of information supply against the nuclear power generation

    Energy Technology Data Exchange (ETDEWEB)

    Shimooka, Hiroshi [Institute of Applied Energy, Tokyo (Japan)

    2001-01-01

    The Energy Engineering Research Institute carried out six times of questionnaire on analysis of public consciousness structure for fiscal years for 1986 to 1999, to obtain a lot of informations on public recognition against the nuclear power generation. In recent, as a feasibility on change of consciousness against the power generation was supposed by occurrence of the JCO critical accident forming the first victim in Japan on September, 1999 after investigation in fiscal year 1998, by carrying out the same questionnaire as one in previous fiscal year to the same objects after the accident, to analyze how evaluation, behavior determining factor and so forth on the power generation changed by the accident. In this paper, on referring to results of past questionnaires, were introduced on the questionnaire results and their analysis carried out before and after the JCO critical accident, to consider on information supply referred by them. (G.K.)

  14. Research of second harmonic generation images based on texture analysis

    Science.gov (United States)

    Liu, Yao; Li, Yan; Gong, Haiming; Zhu, Xiaoqin; Huang, Zufang; Chen, Guannan

    2014-09-01

    Texture analysis plays a crucial role in identifying objects or regions of interest in an image. It has been applied to a variety of medical image processing, ranging from the detection of disease and the segmentation of specific anatomical structures, to differentiation between healthy and pathological tissues. Second harmonic generation (SHG) microscopy as a potential noninvasive tool for imaging biological tissues has been widely used in medicine, with reduced phototoxicity and photobleaching. In this paper, we clarified the principles of texture analysis including statistical, transform, structural and model-based methods and gave examples of its applications, reviewing studies of the technique. Moreover, we tried to apply texture analysis to the SHG images for the differentiation of human skin scar tissues. Texture analysis method based on local binary pattern (LBP) and wavelet transform was used to extract texture features of SHG images from collagen in normal and abnormal scars, and then the scar SHG images were classified into normal or abnormal ones. Compared with other texture analysis methods with respect to the receiver operating characteristic analysis, LBP combined with wavelet transform was demonstrated to achieve higher accuracy. It can provide a new way for clinical diagnosis of scar types. At last, future development of texture analysis in SHG images were discussed.

  15. Entropy generation analysis of an adsorption cooling cycle

    KAUST Repository

    Thu, Kyaw

    2013-05-01

    This paper discusses the analysis of an adsorption (AD) chiller using system entropy generation as a thermodynamic framework for evaluating total dissipative losses that occurred in a batch-operated AD cycle. The study focuses on an adsorption cycle operating at heat source temperatures ranging from 60 to 85 °C, whilst the chilled water inlet temperature is fixed at 12.5 °C,-a temperature of chilled water deemed useful for dehumidification and cooling. The total entropy generation model examines the processes of key components of the AD chiller such as the heat and mass transfer, flushing and de-superheating of liquid refrigerant. The following key findings are observed: (i) The cycle entropy generation increases with the increase in the heat source temperature (10.8 to 46.2 W/K) and the largest share of entropy generation or rate of energy dissipation occurs at the adsorption process, (ii) the second highest energy rate dissipation is the desorption process, (iii) the remaining energy dissipation rates are the evaporation and condensation processes, respectively. Some of the noteworthy highlights from the study are the inevitable but significant dissipative losses found in switching processes of adsorption-desorption and vice versa, as well as the de-superheating of warm condensate that is refluxed at non-thermal equilibrium conditions from the condenser to the evaporator for the completion of the refrigeration cycle. © 2012 Elsevier Ltd. All rights reserved.

  16. Thermal analysis of high speed permanent magnetic generator

    Institute of Scientific and Technical Information of China (English)

    LI WeiLi; ZHANG XiaoChen; CHENG ShuKang; CAO JunCi; ZHANG YiHuang

    2012-01-01

    High-speed permanent magnetic generators (HSPMG) are common and important power generation equipments used in distributed generation systems.A 100 kW level HSPMG is investigated in this paper,and it is fluid-thermal coupling analyzed.The transient 2D electromagnetic field while machine is under rated operating is analyzed by using the time-stepping FEM,from which the electromagnetic performances and the loss distributions are obtained.Then,an analysis model for fluid-solid temperature field analysis is established.Taking losses as the distributed heat sources,the 3D thermal field is coupling calculated.The variations of heat transfer coefficient and temperature of fluid in stator grooves along the axial direction,as well as the whole region 3D temperature distribution in HSPMG are obtained.Then,considering the variations of heat sources distributions and heat transfer conditions,3D temperature fields of HSPMG operating under different speeds are calculated,and the influences of machine operating speed on the HSPMG thermal performance are studied,based on which,the functions of machine temperature with operating speed and stator windings resistance are proposed.The obtained conclusions may provide a useful reference for the design and research of HSPMG.

  17. Cost-based Optimal Distributed Generation Planning with Considering Voltage Depended Loads and Power Factor of Distributed Generation

    Directory of Open Access Journals (Sweden)

    Babak Yousefi-Khangah

    2014-12-01

    Full Text Available If determination of location and size of Distributed Generation (DG are applied accurately, the DG’s ability will improve the network situation and reduce operation costs. In this paper, various market conditions are considered to maximize the benefit of DG’s presence and make a trade off among advantages of DG, network situation, and Distribution Company (DISCO owners. To determine the optimal location and size of DG, two methods of the cost minimization and the nodal pricing are combined. In addition to evaluating the impact of parameters such as variation of energy price and load on objective function, effect of these parameters on location and size of DG is considered. To confirm the results, impact of loads which are dependent on voltage and variation of the power factor of the DG units is applied and then effect of power factor on optimal location and size of DG is shown. A method is proposed for convergence of different results which is caused by different power factors. To observe long-term impact of the DG’s presence in the network, a load growth for five years is considered annually. Study is carried out on IEEE30 bus test circuit.

  18. Nominal Performance Biosphere Dose Conversion Factor Analysis

    Energy Technology Data Exchange (ETDEWEB)

    M. Wasiolek

    2004-09-08

    This analysis report is one of the technical reports containing documentation of the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the Total System Performance Assessment (TSPA) for the license application (LA) for the Yucca Mountain repository. This analysis report describes the development of biosphere dose conversion factors (BDCFs) for the groundwater exposure scenario, and the development of conversion factors for assessing compliance with the groundwater protection standard. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1-1. This figure shows the interrelationships among the products (i.e., analysis and model reports) developed for biosphere modeling and provides an understanding of how this analysis report contributes to biosphere modeling. This report is one of two reports that develop biosphere BDCFs, which are input parameters for the TSPA-LA model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes in detail the ERMYN conceptual model and mathematical model. The input parameter reports, shown to the right of the ''Biosphere Model Report'' in Figure 1-1, contain detailed description of the model input parameters, their development, and the relationship between the parameters and specific features events and processes (FEPs). This report describes biosphere model calculations and their output, the BDCFs, for the groundwater exposure scenario. The objectives of this analysis are to develop BDCFs for the groundwater exposure scenario for the three climate states considered in the TSPA-LA as well as conversion factors for evaluating compliance with the groundwater protection standard. The BDCFs will be used in performance assessment for calculating all-pathway annual doses for a given concentration of radionuclides in groundwater. The conversion factors will be used for calculating gross alpha particle

  19. Exploratory factor analysis in Rehabilitation Psychology: a content analysis.

    Science.gov (United States)

    Roberson, Richard B; Elliott, Timothy R; Chang, Jessica E; Hill, Jessica N

    2014-11-01

    Our objective was to examine the use and quality of exploratory factor analysis (EFA) in articles published in Rehabilitation Psychology. Trained raters examined 66 separate exploratory factor analyses in 47 articles published between 1999 and April 2014. The raters recorded the aim of the EFAs, the distributional statistics, sample size, factor retention method(s), extraction and rotation method(s), and whether the pattern coefficients, structure coefficients, and the matrix of association were reported. The primary use of the EFAs was scale development, but the most widely used extraction and rotation method was principle component analysis, with varimax rotation. When determining how many factors to retain, multiple methods (e.g., scree plot, parallel analysis) were used most often. Many articles did not report enough information to allow for the duplication of their results. EFA relies on authors' choices (e.g., factor retention rules extraction, rotation methods), and few articles adhered to all of the best practices. The current findings are compared to other empirical investigations into the use of EFA in published research. Recommendations for improving EFA reporting practices in rehabilitation psychology research are provided.

  20. Solar Stirling power generation - Systems analysis and preliminary tests

    Science.gov (United States)

    Selcuk, M. K.; Wu, Y.-C.; Moynihan, P. I.; Day, F. D., III

    1977-01-01

    The feasibility of an electric power generation system utilizing a sun-tracking parabolic concentrator and a Stirling engine/linear alternator is being evaluated. Performance predictions and cost analysis of a proposed large distributed system are discussed. Design details and preliminary test results are presented for a 9.5 ft diameter parabolic dish at the Jet Propulsion Laboratory (Caltech) Table Mountain Test Facility. Low temperature calorimetric measurements were conducted to evaluate the concentrator performance, and a helium flow system is being used to test the solar receiver at anticipated working fluid temperatures (up to 650 or 1200 C) to evaluate the receiver thermal performance. The receiver body is designed to adapt to a free-piston Stirling engine which powers a linear alternator assembly for direct electric power generation. During the next phase of the program, experiments with an engine and receiver integrated into the concentrator assembly are planned.

  1. DEVELOPMENT OF QUESTIONNAIRE FOR MEASURING FACTORS OF SIGNIFICANCE OF AN ELDERLY PERSON AS ANOTHER FOR THE YOUNGER GENERATION

    Directory of Open Access Journals (Sweden)

    Natalia V. KHALINA

    2015-01-01

    Full Text Available Social and political processes of the present time, actualize in the minds of the younger generation of Russians importance for the development of the country. But it would be wrong to assume no significant experience in the elderly and to consider identity apart from family ties. Relevance to this key acts the process of intergenerational transmission, when the younger generation can assimilate the experience of close, meaningful elderly. The paper drew attention to the dedicated A.V. Petrovsky importance of interpersonal factors: credibility (reference, attraction (emotional state, institutionalized role (power status. On the basis of the three-factor model proposed by the author's questionnaire for measuring factors like the importance of an elderly as a significant Another for the younger generation. The authors conducted a tested methodology for determining the significance of an old man for youth. The statistical analysis survey was conducted using a Rasch model, which is an important feature of the subjective objectivity of assessments. It shows the process of correction of the questionnaire based on the theory of measurement of latent variables. Designed questionnaire contains twenty-four judgments, respondents were asked to express the degree of agreement with these judgments in four grades. Thus, twenty-four indicator variables actually measure the latent variable "importance of the elderly as a significant Another for the younger generation", and are compatible with each other, enabling them to measure the factors, the importance of the elderly as a significant Another for the younger generation: the authority of the (reference, attraction (emotional status institutionalized the role of (status of power.

  2. Analysis of Ultra Linguistic Factors in Interpretation

    Institute of Scientific and Technical Information of China (English)

    姚嘉

    2015-01-01

    The quality of interpretation is a dynamic conception, involving a good deal of variables, such as the participants, the situations, working conditions, cultures etc.. Therefore, in interpretation, those static elements, such as traditional grammars and certain linguistic rules can not be counted as the only criteria for the quality of interpretation. That is, there are many other non-language elements—Ultra-linguistic factors that play an important role in interpretation. Ultra-linguistic factors get rid of the bounding of traditional grammar and parole, and reveal the facts in an indirect way. This paper gives a brief analysis of Ultra Lin⁃guistic elements in interpretation in order to achieve better result in interpretation practice.

  3. Factor Rotation and Standard Errors in Exploratory Factor Analysis

    Science.gov (United States)

    Zhang, Guangjian; Preacher, Kristopher J.

    2015-01-01

    In this article, we report a surprising phenomenon: Oblique CF-varimax and oblique CF-quartimax rotation produced similar point estimates for rotated factor loadings and factor correlations but different standard error estimates in an empirical example. Influences of factor rotation on asymptotic standard errors are investigated using a numerical…

  4. Rapid Process to Generate Beam Envelopes for Optical System Analysis

    Science.gov (United States)

    Howard, Joseph; Seals, Lenward

    2012-01-01

    The task of evaluating obstructions in the optical throughput of an optical system requires the use of two disciplines, and hence, two models: optical models for the details of optical propagation, and mechanical models for determining the actual structure that exists in the optical system. Previous analysis methods for creating beam envelopes (or cones of light) for use in this obstruction analysis were found to be cumbersome to calculate and take significant time and resources to complete. A new process was developed that takes less time to complete beam envelope analysis, is more accurate and less dependent upon manual node tracking to create the beam envelopes, and eases the burden on the mechanical CAD (computer-aided design) designers to form the beam solids. This algorithm allows rapid generation of beam envelopes for optical system obstruction analysis. Ray trace information is taken from optical design software and used to generate CAD objects that represent the boundary of the beam envelopes for detailed analysis in mechanical CAD software. Matlab is used to call ray trace data from the optical model for all fields and entrance pupil points of interest. These are chosen to be the edge of each space, so that these rays produce the bounding volume for the beam. The x and y global coordinate data is collected on the surface planes of interest, typically an image of the field and entrance pupil internal of the optical system. This x and y coordinate data is then evaluated using a convex hull algorithm, which removes any internal points, which are unnecessary to produce the bounding volume of interest. At this point, tolerances can be applied to expand the size of either the field or aperture, depending on the allocations. Once this minimum set of coordinates on the pupil and field is obtained, a new set of rays is generated between the field plane and aperture plane (or vice-versa). These rays are then evaluated at planes between the aperture and field, at a

  5. Dynamic Range Analysis of the Phase Generated Carrier Demodulation Technique

    Directory of Open Access Journals (Sweden)

    M. J. Plotnikov

    2014-01-01

    Full Text Available The dependence of the dynamic range of the phase generated carrier (PGC technique on low-pass filters passbands is investigated using a simulation model. A nonlinear character of this dependence, which could lead to dynamic range limitations or measurement uncertainty, is presented for the first time. A detailed theoretical analysis is provided to verify the simulation results and these results are consistent with performed calculations. The method for the calculation of low-pass filters passbands according to the required dynamic range upper limit is proposed.

  6. Computer Analysis of 400 HZ Aircraft Electrical Generator Test Data.

    Science.gov (United States)

    1980-06-01

    7 D-AIO0 705 AIR FORCE INST OF TECH WRIGHT-PATTERSON AlS OH SCHOO-CTC F/ /2 AOMPUTER ANALYSIS OF 400 HZ AIRCRAFT ELECTRICAL GEERATOR TES JUN 80 P G...software system to analyze the data available from the Generator-Test Facility. I - -- - --- - - - - -- I, 0 Co 4.3 CO COm- I : W z I 40 g(2) • 10 4 E- c...triangles. Figure 4 presents the basis for the following linear inter- polation used to estimate time of zero crossover. Z T = ___- (T 2-T 1 ) + T1(4

  7. The three pillar strategy for power generation mix - An analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kehlhofer, Rolf; Hatt, Stefan

    2010-09-15

    Low carbon intensity, load following capability and least cost production are the requirements for a successful energy generation mix. This paper presents an analysis of an optimized mix of technologies 'fulfilling the above criteria' based on the energy production portfolio of a number of key countries. The subjects covered include: - comparison of different production technologies (including future costs of emissions) - grid requirements for flexible and dispatchable variable production capabilities - possibilities and limitations of energy production from renewables - why improved overall energy efficiency leads to higher consumption of electricity.

  8. Using proximate analysis to characterize airborne dust generation from bituminous coals

    Energy Technology Data Exchange (ETDEWEB)

    Page, S.J.; Organiscak, J.A. [NIOSH, Pittsburgh, PA (United States). Pittsburgh Research Lab.

    2002-06-01

    Laboratory crushing experiments were conducted on a range of low to high volatile bituminous coals to investigate the various factors influencing airborne respirable dust generation. Bituminous coal samples from 8 mines (5 U.S. and 3 Polish) were uniformly prepared and processed through a double roll crusher located in a low air velocity wind tunnel. Experimental factors studied included inherent coal seam constituents, specific energy of crushing, product size characteristics, dust cloud electrostatic field, and specific quantity of airborne respirable dust generated. A combination of factors is associated with the generation of airborne respirable dust. One factor involved is the effect of coal rank, described by the inherent moist fuel ratio, on the product size characteristics. However, since coals of high moist fuel ratio (high rank) are generally more extensively cleated, it is suggested that the degree of cleating is directly responsible for the quantity of respirable-sized particles produced in the crushed product material for eastern U.S. coals. This is implied by the relationship of ash content and at least one mineral constituent (pyrite, determined from pyritic sulfur analysis) to the percentage of airborne respirable dust. A clear delineation of coals, based on well-known proximate analysis characteristics, that generate the most respirable dust appears to be possible. It was also shown that the dust-generating characteristics of coals could be reasonably described by both the moist fuel ratio and the Hardgrove Grindability Index (HGI). These results show a clear distinction between eastern and western U.S. coals. However, no consistent distinction for Polish coal was observed.

  9. Generation Y Student-Teachers' Motivational Factors: Retention Implications for K-12 Educational Leaders

    Science.gov (United States)

    Bontempo, Brian

    2010-01-01

    Generation Y represents a growing number of student-teachers who will impact the future of educational practice, yet little research has been conducted for this demographic group. The purpose of this mixed-method study was to identify motivational factors of neophyte teachers and the retention implications these findings had on Kindergarten…

  10. Low socioeconomic status is a risk factor for preeclampsia: the Generation R Study.

    NARCIS (Netherlands)

    L.M. Silva (Lindsay); M. Coolman (Marianne); E.A.P. Steegers (Eric); V.W.V. Jaddoe (Vincent); H.A. Moll (Henriëtte); A. Hofman (Albert); J.P. Mackenbach (Johan); H. Raat (Hein)

    2008-01-01

    textabstractObjectives: To examine whether maternal socioeconomic status, as indicated by maternal educational level, is associated with preeclampsia, and if so, to what extent known risk factors for preeclampsia mediate the effect of educational level. Methods: In the Generation R Study, a populat

  11. Model correction factor method for system analysis

    DEFF Research Database (Denmark)

    Ditlevsen, Ove Dalager; Johannesen, Johannes M.

    2000-01-01

    The Model Correction Factor Method is an intelligent response surface method based on simplifiedmodeling. MCFM is aimed for reliability analysis in case of a limit state defined by an elaborate model. Herein it isdemonstrated that the method is applicable for elaborate limit state surfaces on which...... severallocally most central points exist without there being a simple geometric definition of the corresponding failuremodes such as is the case for collapse mechanisms in rigid plastic hinge models for frame structures. Taking as simplifiedidealized model a model of similarity with the elaborate model...... surface than existing in the idealized model....

  12. Testing the number of required dimensions in exploratory factor analysis

    Directory of Open Access Journals (Sweden)

    Achim, Andr\\'e

    2017-01-01

    Full Text Available While maximum likelihood exploratory factor analysis (EFA provides a statistical test that $k$ dimensions are sufficient to account for the observed correlations among a set of variables, determining the required number of factors in least-squares based EFA has essentially relied on heuristic procedures. Two methods, Revised Parallel Analysis (R-PA and Comparison Data (CD, were recently proposed that generate surrogate data based on an increasing number of principal axis factors in order to compare their sequence of eigenvalues with that from the data. The latter should be unremarkable among the former if enough dimensions are included. While CD looks for a balance between efficiency and parsimony, R-PA strictly test that $k$ dimensions are sufficient by ranking the next eigenvalue, i.e. at rank $k+1$, of the actual data among those from the surrogate data. Importing two features of CD into R-PA defines four variants that are here collectively termed Next Eigenvalue Sufficiency Tests (NESTs. Simulations implementing 144 sets of parameters, including correlated factors and presence of a doublet factor, show that all four NESTs largely outperform CD, the standard Parallel Analysis, the Mean Average Partial method and even the maximum likelihood approach, in identifying the correct number of common factors. The recommended, most successful NEST variant is also the only one that never overestimates the correct number of dimensions beyond its nominal $\\alpha$ level. This variant is made available as R and MATLAB code as well as a complement incorporated in a Microsoft Excel file.

  13. Analysis Tools for Next-Generation Hadron Spectroscopy Experiments

    CERN Document Server

    Battaglieri, M; Celentano, A; Chung, S -U; D'Angelo, A; De Vita, R; Döring, M; Dudek, J; Eidelman, S; Fegan, S; Ferretti, J; Fox, G; Galata, G; Garcia-Tecocoatzi, H; Glazier, D I; Grube, B; Hanhart, C; Hoferichter, M; Hughes, S M; Ireland, D G; Ketzer, B; Klein, F J; Kubis, B; Liu, B; Masjuan, P; Mathieu, V; McKinnon, B; Mitchell, R; Nerling, F; Paul, S; Pelaez, J R; Rademacker, J; Rizzo, A; Salgado, C; Santopinto, E; Sarantsev, A V; Sato, T; Schlüter, T; da Silva, M L L; Stankovic, I; Strakovsky, I; Szczepaniak, A; Vassallo, A; Walford, N K; Watts, D P; Zana, L

    2014-01-01

    The series of workshops on New Partial-Wave Analysis Tools for Next-Generation Hadron Spectroscopy Experiments was initiated with the ATHOS 2012 meeting, which took place in Camogli, Italy, June 20-22, 2012. It was followed by ATHOS 2013 in Kloster Seeon near Munich, Germany, May 21-24, 2013. The third, ATHOS3, meeting is planned for April 13-17, 2015 at The George Washington University Virginia Science and Technology Campus, USA. The workshops focus on the development of amplitude analysis tools for meson and baryon spectroscopy, and complement other programs in hadron spectroscopy organized in the recent past including the INT-JLab Workshop on Hadron Spectroscopy in Seattle in 2009, the International Workshop on Amplitude Analysis in Hadron Spectroscopy at the ECT*-Trento in 2011, the School on Amplitude Analysis in Modern Physics in Bad Honnef in 2011, the Jefferson Lab Advanced Study Institute Summer School in 2012, and the School on Concepts of Modern Amplitude Analysis Techniques in Flecken-Zechlin near...

  14. Scalable group level probabilistic sparse factor analysis

    DEFF Research Database (Denmark)

    Hinrich, Jesper Løve; Nielsen, Søren Føns Vind; Riis, Nicolai Andre Brogaard

    2017-01-01

    Many data-driven approaches exist to extract neural representations of functional magnetic resonance imaging (fMRI) data, but most of them lack a proper probabilistic formulation. We propose a scalable group level probabilistic sparse factor analysis (psFA) allowing spatially sparse maps, component...... pruning using automatic relevance determination (ARD) and subject specific heteroscedastic spatial noise modeling. For task-based and resting state fMRI, we show that the sparsity constraint gives rise to components similar to those obtained by group independent component analysis. The noise modeling...... shows that noise is reduced in areas typically associated with activation by the experimental design. The psFA model identifies sparse components and the probabilistic setting provides a natural way to handle parameter uncertainties. The variational Bayesian framework easily extends to more complex...

  15. Disruptive Event Biosphere Dose Conversion Factor Analysis

    Energy Technology Data Exchange (ETDEWEB)

    M. Wasiolek

    2004-09-08

    This analysis report is one of the technical reports containing documentation of the Environmental Radiation Model for Yucca Mountain, Nevada (ERMYN), a biosphere model supporting the total system performance assessment (TSPA) for the license application (LA) for the Yucca Mountain repository. This analysis report describes the development of biosphere dose conversion factors (BDCFs) for the volcanic ash exposure scenario, and the development of dose factors for calculating inhalation dose during volcanic eruption. A graphical representation of the documentation hierarchy for the ERMYN is presented in Figure 1-1. This figure shows the interrelationships among the products (i.e., analysis and model reports) developed for biosphere modeling and provides an understanding of how this analysis report contributes to biosphere modeling. This report is one of two reports that develop biosphere BDCFs, which are input parameters for the TSPA model. The ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) describes in detail the ERMYN conceptual model and mathematical model. The input parameter reports, shown to the right of the Biosphere Model Report in Figure 1-1, contain detailed descriptions of the model input parameters, their development and the relationship between the parameters and specific features, events and processes (FEPs). This report describes biosphere model calculations and their output, the BDCFs, for the volcanic ash exposure scenario. This analysis receives direct input from the outputs of the ''Biosphere Model Report'' (BSC 2004 [DIRS 169460]) and from the five analyses that develop parameter values for the biosphere model (BSC 2004 [DIRS 169671]; BSC 2004 [DIRS 169672]; BSC 2004 [DIRS 169673]; BSC 2004 [DIRS 169458]; and BSC 2004 [DIRS 169459]). The results of this report are further analyzed in the ''Biosphere Dose Conversion Factor Importance and Sensitivity Analysis''. The objective of this

  16. Performance Model and Sensitivity Analysis for a Solar Thermoelectric Generator

    Science.gov (United States)

    Rehman, Naveed Ur; Siddiqui, Mubashir Ali

    2017-01-01

    In this paper, a regression model for evaluating the performance of solar concentrated thermoelectric generators (SCTEGs) is established and the significance of contributing parameters is discussed in detail. The model is based on several natural, design and operational parameters of the system, including the thermoelectric generator (TEG) module and its intrinsic material properties, the connected electrical load, concentrator attributes, heat transfer coefficients, solar flux, and ambient temperature. The model is developed by fitting a response curve, using the least-squares method, to the results. The sample points for the model were obtained by simulating a thermodynamic model, also developed in this paper, over a range of values of input variables. These samples were generated employing the Latin hypercube sampling (LHS) technique using a realistic distribution of parameters. The coefficient of determination was found to be 99.2%. The proposed model is validated by comparing the predicted results with those in the published literature. In addition, based on the elasticity for parameters in the model, sensitivity analysis was performed and the effects of parameters on the performance of SCTEGs are discussed in detail. This research will contribute to the design and performance evaluation of any SCTEG system for a variety of applications.

  17. Analysis of Aerodynamic Noise Generated from Inclined Circular Cylinder

    Institute of Scientific and Technical Information of China (English)

    YasutakeHaramoto; ShoujiYasuda; 等

    2000-01-01

    Making clear the generation mechanism of fluid dynamic noise is essential to reduce noise deriving from turbomachinery.The analysis of the aerodynamic noise generated from circular cylinder is carried out numerically and experimentally in a low noise wind tunnel.in this study,aerodynamic sound radiated from a circular cylinder in uniform flow is predicted numericaslly by the following two step method,First,the three-dimensional unsteady incompressible Navier-Stokes equation is solved using the high order accurate upwind scheme.Next.the sound pressure level at the observed point is calculated from the fluctuating surface pressure on the cylinder.based on modified Lighthill-Curl's equation.It is worth to note that the noise generated from the model is reduced rapidly when it is inclined against the mean flow.In other works,the Peak level of the radiated noise decreases apidly with inclination of the circular cylinder.The simulated SPL for the inclined circular cylinder is compared with the measured value .and good agreement is obtained for the peak spectrum fequency of the sound pressue level and tendency of noise reduction,So we expect that the change of flow structures makes reduction of the aerodynamic noise from the inclined models.

  18. Sensitivity analysis of surface runoff generation in urban flood forecasting.

    Science.gov (United States)

    Simões, N E; Leitão, J P; Maksimović, C; Sá Marques, A; Pina, R

    2010-01-01

    Reliable flood forecasting requires hydraulic models capable to estimate pluvial flooding fast enough in order to enable successful operational responses. Increased computational speed can be achieved by using a 1D/1D model, since 2D models are too computationally demanding. Further changes can be made by simplifying 1D network models, removing and by changing some secondary elements. The Urban Water Research Group (UWRG) of Imperial College London developed a tool that automatically analyses, quantifies and generates 1D overland flow network. The overland flow network features (ponds and flow pathways) generated by this methodology are dependent on the number of sewer network manholes and sewer inlets, as some of the overland flow pathways start at manholes (or sewer inlets) locations. Thus, if a simplified version of the sewer network has less manholes (or sewer inlets) than the original one, the overland flow network will be consequently different. This paper compares different overland flow networks generated with different levels of sewer network skeletonisation. Sensitivity analysis is carried out in one catchment area in Coimbra, Portugal, in order to evaluate overland flow network characteristics.

  19. Analysis of aerodynamic noise generated from inclined circular cylinder

    Science.gov (United States)

    Haramoto, Yasutake; Yasuda, Shouji; Matsuzaki, Kazuyoshi; Munekata, Mizue; Ohba, Hideki

    2000-06-01

    Making clear the generation mechanism of fluid dynamic noise is essential to reduce noise deriving from turbomachinery. The analysis of the aerodynamic noise generated from circular cylinder is carried out numerically and experimentally in a low noise wind tunnel. In this study, aerodynamic sound radiated from a circular cylinder in uniform flow is predicted numerically by the following two step method. First, the three-dimensional unsteady incompressible Navier-Stokes equation is solved using the high order accurate upwind scheme. Next, the sound pressure level at the observed point is calculated from the fluctuating surface pressure on the cylinder, based on modified Lighthill-Curl’s equation. It is worth to note that the noise generated from the model is reduced rapidly when it is inclined against the mean flow. In other words, the peak level of the radiated noise decreases rapidly with inclination of the circular cylinder. The simulated SPL for the inclined circular cylinder is compared with the measured value, and good agreement is obtained for the peak spectrum frequency of the sound pressure level and tendency of noise reduction. So we expect that the change of flow structures makes reduction of the aerodynamic noise from the inclined models.

  20. Performance Model and Sensitivity Analysis for a Solar Thermoelectric Generator

    Science.gov (United States)

    Rehman, Naveed Ur; Siddiqui, Mubashir Ali

    2017-03-01

    In this paper, a regression model for evaluating the performance of solar concentrated thermoelectric generators (SCTEGs) is established and the significance of contributing parameters is discussed in detail. The model is based on several natural, design and operational parameters of the system, including the thermoelectric generator (TEG) module and its intrinsic material properties, the connected electrical load, concentrator attributes, heat transfer coefficients, solar flux, and ambient temperature. The model is developed by fitting a response curve, using the least-squares method, to the results. The sample points for the model were obtained by simulating a thermodynamic model, also developed in this paper, over a range of values of input variables. These samples were generated employing the Latin hypercube sampling (LHS) technique using a realistic distribution of parameters. The coefficient of determination was found to be 99.2%. The proposed model is validated by comparing the predicted results with those in the published literature. In addition, based on the elasticity for parameters in the model, sensitivity analysis was performed and the effects of parameters on the performance of SCTEGs are discussed in detail. This research will contribute to the design and performance evaluation of any SCTEG system for a variety of applications.

  1. Real Time Engineering Analysis Based on a Generative Component Implementation

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Klitgaard, Jens

    2007-01-01

    The present paper outlines the idea of a conceptual design tool with real time engineering analysis which can be used in the early conceptual design phase. The tool is based on a parametric approach using Generative Components with embedded structural analysis. Each of these components uses...... the geometry, material properties and fixed point characteristics to calculate the dimensions and subsequent feasibility of any architectural design. The proposed conceptual design tool provides the possibility for the architect to work with both the aesthetic as well as the structural aspects of architecture...... with a static determinate roof structure modelled by beam components is given. The example outlines the idea of the tool for conceptual design in early phase of a multidisciplinary design process between architecture and structural engineering....

  2. Real Time Engineering Analysis Based on a Generative Component Implementation

    DEFF Research Database (Denmark)

    Kirkegaard, Poul Henning; Klitgaard, Jens

    2007-01-01

    The present paper outlines the idea of a conceptual design tool with real time engineering analysis which can be used in the early conceptual design phase. The tool is based on a parametric approach using Generative Components with embedded structural analysis. Each of these components uses...... without jumping from aesthetics to structural digital design tools and back, but to work with both simultaneously and real time. The engineering level of knowledge is incorporated at a conceptual thinking level, i.e. qualitative information is used in stead of using quantitative information. An example...... with a static determinate roof structure modelled by beam components is given. The example outlines the idea of the tool for conceptual design in early phase of a multidisciplinary design process between architecture and structural engineering....

  3. A qualitative study of factors influencing different generations of Newfoundland and Saskatchewan trained physicians to leave a work location

    Directory of Open Access Journals (Sweden)

    Mathews Maria

    2012-07-01

    Full Text Available Abstract Background Some studies have suggested that young physicians may have different expectations and practice behaviours than their older generational counterparts, including their reasons for wanting to remain or leave a community. This study examined the factors associated with a physician’s decision to leave a work location. We compared different generations of physicians to assess whether these factors have changed over generations. Methods We conducted semi-structured, qualitative interviews with 48 physicians who graduated from two Canadian medical schools. We asked each physician about the number and nature of work location changes and the factors related to their decisions to leave each location. Interview transcripts and notes were analysed using a thematic analysis approach. Results Dissatisfaction with the working environment was the most frequently cited reason for leaving a location for physicians of all generations. Elements which contributed to the quality of the work environment included the collaborative nature of the practice, the relationship with administrators, and access to resources and personnel. For younger physicians, the work environment had to meet their personal expectations for work-life balance. While remuneration level was given by some physicians as the key reason for leaving a location, for others it was the “last straw” if the work environment was poor. A small number of older generation physicians moved in response to political events and/or policies Conclusions We documented generational differences in physicians’ reasons for choosing a work location. We found that a poor work environment was universally the most important reason why a physician chose to leave a location. A few physicians who were unsatisfied with their work location identified level of remuneration as an additional reason for leaving. Some older generation physicians cited political climate as a reason for leaving a work

  4. Design and analysis of solar thermoelectric power generation system

    Science.gov (United States)

    Vatcharasathien, Narong; Hirunlabh, Jongjit; Khedari, Joseph; Daguenet, Michel

    2005-09-01

    This article reports on the design and performance analysis of a solar thermoelectric power generation plant (STEPG). The system considers both truncated compound parabolic collectors (CPCs) with a flat receiver and conventional flat-plate collectors, thermoelectric (TE) cooling and power generator modules and appropriate connecting pipes and control devices. The design tool uses TRNSYS IIsibat-15 program with a new component we developed for the TE modules. The main input data of the system are the specifications of TE module, the maximum hot side temperature of TE modules, and the desired power output. Examples of the design using truncated CPC and flat-plate collectors are reported and discussed for various slope angle and half-acceptance angle of CPC. To minimize system cost, seasonal adjustment of the slope angle between 0° and 30° was considered, which could give relatively high power output under Bangkok ambient condition. Two small-scale STEPGs were built. One of them uses electrical heater, whereas the other used a CPC with locally made aluminum foil reflector. Measured data showed reasonable agreement with the model outputs. TE cooling modules were found to be more appropriate. Therefore, the TRNSYS software and the developed TE component offer an extremely powerful tool for the design and performance analysis of STEPG plant.

  5. Computational Particle Physics for Event Generators and Data Analysis

    CERN Document Server

    Perret-Gallix, Denis

    2013-01-01

    High-energy physics data analysis relies heavily on the comparison between experimental and simulated data as stressed lately by the Higgs search at LHC and the recent identification of a Higgs-like new boson. The first link in the full simulation chain is the event generation both for background and for expected signals. Nowadays event generators are based on the automatic computation of matrix element or amplitude for each process of interest. Moreover, recent analysis techniques based on the matrix element likelihood method assign probabilities for every event to belong to any of a given set of possible processes. This method originally used for the top mass measurement, although computing intensive, has shown its power at LHC to extract the new boson signal from the background. Serving both needs, the automatic calculation of matrix element is therefore more than ever of prime importance for particle physics. Initiated in the eighties, the techniques have matured for the lowest order calculations (tree-le...

  6. Analysis of once-through steam generator instability

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Han Ok; Kang, Hyung Suk; Cho, Bong Hyun; Yoon, Ju Hyeon [Korea Atomic Energy Research Institute, Taejon (Korea)

    1998-03-01

    KAERI is carrying out a development of the design for a new type of integral reactor named SMART (System-integrated Modular Advanced Reactor). Two models, the frequency domain-linear model and the time domain-nonlinear model, are developed for the analysis of once-through helical steam generator flow instability. The linear model is used for easy determination of critical point with constant heat flux condition. The nonlinear model is for the analysis of oscillation characteristics beyond the critical point as well as determination of the point with real primary boundary conditions. The developed linear model is utilized to evaluate the effect of several nondimensional parameters on flow stability for the wide range of input conditions. The results from the developed nonlinear model are compared with the existing experimental data including steady state values and critical conditions. The calculated lengths of each region and pressure drops in the steady show almost same trends with Nariai's experimental results. Two developed models can be utilized to analyze the steam generator flow instabilities and to design the inlet orifices are to prevent flow instabilities. (author). 118 refs., 32 figs., 1 tab.

  7. Heat Transfer Analysis for Optimal Design of Radioisotope Thermoelectric Generator

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jong Han; Son, Kwang Jae; Hong, Jintae; Kim, Jong Bum [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    A new approach is need in the space development and requires a technique having a high degree of reliability. For example, there is radioisotope thermoelectric generator(RTG) using radioisotope that has different mechanism in comparison with solar power as power source. This is a technology that has already been trusted by generator for space in the developed countries. For example, RTG is essential for moon explorer because no other power exist source night of moon. In this study, we investigated the thermal efficiency according to the structure of RTG. Specifically, the thermal properties were analyzed according to the presence of the shield inside vacuum heat-insulating part of the RTG through the finite element analysis. Finite element analysis was used to analyze the characteristics of the temperature distribution in the RTG models according to the shield. The structure of the shield came out less heat loss than the structure without shield. As a result, the structure with a shield is advantage in the RTG design.

  8. Photochemical Process Modeling and Analysis of Ozone Generation

    Institute of Scientific and Technical Information of China (English)

    王冰; 邱彤; 陈丙珍

    2014-01-01

    Air pollution in modern city and industrial zones has become a serious public concern in recent years in China. Significance of air quality assessment and emission control strategy design is increasing. Most studies in China focus on particulate matter (PM), especially PM2.5, while few account for photochemical secondary air pol-lutions represented by ozone (O3). In this paper, a procedure for air quality simulation with comprehensive air quality model with extensions (CAMx) is demonstrated for studying the photochemical process and ozone generation in the troposphere. As a case study, the CAMx photochemical grid model is used to model ozone over southern part of Beijing city in winter, 2011. The input parameters to CAMx include emission sources, meteorology field data, terrain definition, photolysis status, initial and boundary conditions. The simulation results are verified by theoretical analysis of the ozone generation tendency. The simulated variation tendency of domain-wide average value of hourly ozone concentration coincides reasonably well with the theoretical analysis on the atmospheric photochemical process, demonstrating the effectiveness of the procedure. An integrated model system that cooperates with CAMx will be established in our future work.

  9. Exploring factors influencing voluntary turnover intent of Generation X public servants: A South African case

    Directory of Open Access Journals (Sweden)

    Hester Nienaber

    2012-12-01

    Full Text Available Purpose: The purpose of this article is to report on the factors perceived to influence the turnover intent of Generation X public servants. The problem: The researcher investigated the factors that Generation X public servants in South Africa perceive as influencing their turnover intent. Design: The problem was studied by way of a case study. The data were collected by means of semi-structured interviews. A total of eight purposively selected Generation X public servants participated in this study. Findings: The findings of the study show that the factors influencing the turnover intent of the Generation X public servants correspond to some of those proposed in the literature, including the nature of the job, traditional attitudes, and organisational context, both on the macro- and the micro-levels. Furthermore, these factors are also congruent with the drivers of engagement as set out in the literature, specifically content, coping, compensation, community and career. One of the implications of the findings of this study is that although the value of employees to organisations were established as long ago as the Renaissance, organisations still do not capitalise on their most important asset. It is in particular the direct (line manager that plays a crucial role in optimising the value-add of employees. Value: This study is original as it was the first to investigate the turnover intentions of Generation X public servants. Generation X employees are important as they are deemed to be the knowledge repositories of organisations and they are next in line to support the organisation when the Baby Boomers retire. The perceived turnover intentions correspond to some of the components of the generic turnover model proposed by Holtom et al. (2008. The question that arises is whether the turnover intentions of Generation X are any different from other generations. Conclusions: Given their unique characteristics, Generation X is a turnover risk, which

  10. Generations.

    Science.gov (United States)

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession.

  11. Key Success Factors of 3rd Generation Mobile Network Services for M-Commerce in Malaysia

    Directory of Open Access Journals (Sweden)

    Saravanan Muthaiyah

    2004-01-01

    Full Text Available While there has been a great deal of excitement in view of M-commerce, very little is actually known about conditions and critical success factors for successful introduction of the 3rd generation mobile network services here in Malaysia. This study investigates the factors for successful diffusion of 3G network services and their role in advancing an interactive marketplace. 3G which simply means 3rd generation mobile communications technology has been widely discussed by many telecommunications service providers. It was launched by the International Telecommunication Union (ITU some 13 years ago. 3G is viewed as an enabler of M-Commerce here in Malaysia. However, true success of this technology depends on various factors. The objective of this study is to investigate significant key enablers of 3G deployment and adoption in Malaysia. An insight into the critical factors to be considered for the deployment of 3G technology in Malaysia and experiences of other countries will be used as a benchmark to understand the mitigating factors of 3G deployment. Critical factors such as cost to of service, interoperability of standards, insufficiency of mobile services or content and deficiency of the laws will be discussed in this study. The study also discusses diffusion barriers and drivers for the rapid service diffusion of 3G mobile networks.

  12. Factorized molecular wave functions: Analysis of the nuclear factor

    Energy Technology Data Exchange (ETDEWEB)

    Lefebvre, R., E-mail: roland.lefebvre@u-psud.fr [Institut des Sciences Moléculaires d’ Orsay, Bâtiment 350, UMR8214, CNRS- Université. Paris-Sud, 91405 Orsay, France and Sorbonne Universités, UPMC Univ Paris 06, UFR925, F-75005 Paris (France)

    2015-06-07

    The exact factorization of molecular wave functions leads to nuclear factors which should be nodeless functions. We reconsider the case of vibrational perturbations in a diatomic species, a situation usually treated by combining Born-Oppenheimer products. It was shown [R. Lefebvre, J. Chem. Phys. 142, 074106 (2015)] that it is possible to derive, from the solutions of coupled equations, the form of the factorized function. By increasing artificially the interstate coupling in the usual approach, the adiabatic regime can be reached, whereby the wave function can be reduced to a single product. The nuclear factor of this product is determined by the lowest of the two potentials obtained by diagonalization of the potential matrix. By comparison with the nuclear wave function of the factorized scheme, it is shown that by a simple rectification, an agreement is obtained between the modified nodeless function and that of the adiabatic scheme.

  13. Factors Related to Upper Gastrointestinal Symptom Generation in 2275 Helicobacter pylori Seroprevalent Adults.

    Science.gov (United States)

    Lee, Sang Pyo; Lee, Sun-Young; Kim, Jeong Hwan; Sung, In-Kyung; Park, Hyung Seok; Shim, Chan Sup

    2017-06-01

    Upper gastrointestinal (UGI) symptoms are common; however, the role of Helicobacter pylori and gastric corpus atrophy in the generation of these symptoms is controversial. The aim of this study was to determine the risk factors for UGI symptoms in adults in an endemic area of H. pylori infection. Korean adults who completed questionnaires on the day of serum anti-H. pylori IgG and pepsinogen (PG) assays before UGI endoscopy were included. Gastric corpus atrophy was based on the criteria of a serum PG I/II ratio pylori serology assay was positive in 1382 (60.7%) subjects, and gastric corpus atrophy was present in 291 (12.8%). Neither H. pylori seropositivity (p = 0.077) nor gastric corpus atrophy (p = 0.138) was related to the presence of UGI symptoms. Female gender and smoking were independent risk factors for heartburn and upper abdominal pain (all p pylori seroprevalent population, female gender is the most common risk factor followed by smoking for UGI symptom generation. Neither H. pylori seropositivity nor gastric corpus atrophy is an independent risk factor for UGI symptom generation.

  14. Analysis of the control structure of wind energy generation systems based on a permanent magnet synchronous generator

    OpenAIRE

    Carranza Castillo, Oscar; Figueres Amorós, Emilio; Garcerá Sanfeliú, Gabriel; González Medina, Raul

    2013-01-01

    This paper presents the analysis of the two usual control structures for variable speed and fixed pitch wind energy generation systems, namely speed and torque control, to determine the most appropriate structure to improve both robustness and reliability of this kind of distributed generators. The study considers all the elements of a typical wind power generation system and it has been carried out in a general way, so that conclusions are independent of the kind of the AC/DC converter that ...

  15. Analysis of the State of Steam Generator Tubes

    Energy Technology Data Exchange (ETDEWEB)

    Bergunker, Olga [JSC OKB ' Gidropress' , 142103 Podolsk (Russian Federation)

    2008-07-01

    The problem of safe operation of SG heat exchanging tubes, of both economical and effective control of their state is still important these days. Issues connected with peculiarities of methods of SG tubes inspection, automated analysis of the inspection results, tubes state analysis and development of algorithms of forecasting their state are considered in this report. The need for effective use of extensive data arrays on SG operation has led to the necessity of creating software tools for collection, storage and analysis of these data. The data-analytical system 'NPP Steam Generators' meant for data systematization and visualization as well as various types of analyses of data on eddy current inspection of WWER-440 and WWER-1000 SG tubes is presented in this report. The main possibilities of the data-analytical system (DAS), the code current state and prospects of its development are shown. The main fields of DAS application are considered and some results of its practical use are mentioned, namely, in the field of forecasting SG tubes state. (authors)

  16. Factorial invariance in multilevel confirmatory factor analysis.

    Science.gov (United States)

    Ryu, Ehri

    2014-02-01

    This paper presents a procedure to test factorial invariance in multilevel confirmatory factor analysis. When the group membership is at level 2, multilevel factorial invariance can be tested by a simple extension of the standard procedure. However level-1 group membership raises problems which cannot be appropriately handled by the standard procedure, because the dependency between members of different level-1 groups is not appropriately taken into account. The procedure presented in this article provides a solution to this problem. This paper also shows Muthén's maximum likelihood (MUML) estimation for testing multilevel factorial invariance across level-1 groups as a viable alternative to maximum likelihood estimation. Testing multilevel factorial invariance across level-2 groups and testing multilevel factorial invariance across level-1 groups are illustrated using empirical examples. SAS macro and Mplus syntax are provided.

  17. Physiological Factors Analysis in Unpressurized Aircraft Cabins

    Science.gov (United States)

    Patrao, Luis; Zorro, Sara; Silva, Jorge

    2016-11-01

    Amateur and sports flight is an activity with growing numbers worldwide. However, the main cause of flight incidents and accidents is increasingly pilot error, for a number of reasons. Fatigue, sleep issues and hypoxia, among many others, are some that can be avoided, or, at least, mitigated. This article describes the analysis of psychological and physiological parameters during flight in unpressurized aircraft cabins. It relates cerebral oximetry and heart rate with altitude, as well as with flight phase. The study of those parameters might give clues on which variations represent a warning sign to the pilot, thus preventing incidents and accidents due to human factors. Results show that both cerebral oximetry and heart rate change along the flight and altitude in the alert pilot. The impaired pilot might not reveal these variations and, if this is detected, he can be warned in time.

  18. Forecasting municipal solid waste generation using prognostic tools and regression analysis.

    Science.gov (United States)

    Ghinea, Cristina; Drăgoi, Elena Niculina; Comăniţă, Elena-Diana; Gavrilescu, Marius; Câmpean, Teofil; Curteanu, Silvia; Gavrilescu, Maria

    2016-11-01

    For an adequate planning of waste management systems the accurate forecast of waste generation is an essential step, since various factors can affect waste trends. The application of predictive and prognosis models are useful tools, as reliable support for decision making processes. In this paper some indicators such as: number of residents, population age, urban life expectancy, total municipal solid waste were used as input variables in prognostic models in order to predict the amount of solid waste fractions. We applied Waste Prognostic Tool, regression analysis and time series analysis to forecast municipal solid waste generation and composition by considering the Iasi Romania case study. Regression equations were determined for six solid waste fractions (paper, plastic, metal, glass, biodegradable and other waste). Accuracy Measures were calculated and the results showed that S-curve trend model is the most suitable for municipal solid waste (MSW) prediction.

  19. Failure Analysis in Steam Generators: A Study Case

    Directory of Open Access Journals (Sweden)

    Alberto Eduardo Calvo González

    2016-04-01

    Full Text Available The use of crude oil as alternative to fuel steam power stations was justifi ed by economic reasons. Thischange of fuel required to modify the operational procedures, due fundamentally to its lower heating valueand its high density and viscosity. Nevertheless the changes made, the use of the crude oil caused aquick deterioration of the thermal exchange surfaces causing not planned forced outages. The statisticalanalysis of the steam generator forced outages went to reheater number two. Therefore the scope of thiswork is the study of the happened failures in reheater number two, of 433,536 kg/hr, 13,4 MPa, and 525 Ctemperature of superheated and reheated steam generator used to move 125 MW turbines. In the carriedout failure analysis, based on nondestructive evaluation methods, towered with metallographic test, waspossible to clarify the root cause, as well as establish the worsening growth rate that allowed establishingthe sequence of tests to avoid a possible not planned outage. In turn it was possible to choose the kind ofsteel should be used in that reheater to give the defi nitive solution of the problem. While steel substitutionis not carried out it sho uld stay the régime of tests and proposed assays. This experience can serve frombase to the design of a maintenance system based on the condition.

  20. Analysis of a furnace for heat generation using polydisperse biomass

    Energy Technology Data Exchange (ETDEWEB)

    Magalhaes, Edney Alves; Silva, Juarez de Sousa e; Silva, Jadir Nogueira da; Oliveira Filho, Delly [Universidade Federal de Vicosa (DEA/UFV), MG (Brazil). Dept. de Engenharia Agricola; Donzeles, Sergio Mauricio Lopes [Empresa de Pesquisa Agropecuaria de Minas Gerais (EPAMIG), Vicosa, MG (Brazil)

    2008-07-01

    In many agro-industrial activities, the processing of raw material generates a substantial amount of fine materials. Examples include the production of soluble coffee, processing of rice, and wood processing, among others. In many regions, these by-products keep piling up on the courtyard of companies or become an environmental problem for land dumps. However, detailed tests of these byproducts indicate that they are excellent sources of energy. With this in mind, a furnace was developed to generate clean and hot air, using the alimentation system for pneumatic transport. Wood sawdust was used as fuel for analysis. The obtained results were considered satisfactory, proven by the small heat losses, primarily by the non-burned carbon monoxide (less than 0.2%) and the cooling of the furnace (less than 2.5%) whereas the losses by the exhaust gases were a little more than 23%. The thermal efficiency of the furnace was considered high when compared to others with an indirect heating system, obtaining an average value of 73%. The developed furnace, beyond being efficient, allows the use of the waste from the wood industry, which is important in the reduction of environmental impacts and minimizing production costs associated with the acquisition of conventional energy. (author)

  1. Analysis of a furnace for heat generation using polydisperse biomass

    Energy Technology Data Exchange (ETDEWEB)

    Magalhaes, Edney Alves; Silva, Juarez de Sousa e; Silva, Jadir Nogueira da; Oliveira Filho, Delly [Universidade Federal de Vicosa (DEA/UFV), MG (Brazil). Dept. de Engenharia Agricola; Donzeles, Sergio Mauricio Lopes [Empresa de Pesquisa Agropecuaria de Minas Gerais (EPAMIG), Vicosa, MG (Brazil)

    2008-07-01

    In many agro-industrial activities, the processing of raw material generates a substantial amount of fine materials. Examples include the production of soluble coffee, processing of rice, and wood processing, among others. In many regions, these by-products keep piling up on the courtyard of companies or become an environmental problem for land dumps. However, detailed tests of these byproducts indicate that they are excellent sources of energy. With this in mind, a furnace was developed to generate clean and hot air, using the alimentation system for pneumatic transport. Wood sawdust was used as fuel for analysis. The obtained results were considered satisfactory, proven by the small heat losses, primarily by the non-burned carbon monoxide (less than 0.2%) and the cooling of the furnace (less than 2.5%) whereas the losses by the exhaust gases were a little more than 23%. The thermal efficiency of the furnace was considered high when compared to others with an indirect heating system, obtaining an average value of 73%. The developed furnace, beyond being efficient, allows the use of the waste from the wood industry, which is important in the reduction of environmental impacts and minimizing production costs associated with the acquisition of conventional energy. (author)

  2. Unbalance Response Analysis and Experimental Validation of an Ultra High Speed Motor-Generator for Microturbine Generators Considering Balancing

    Directory of Open Access Journals (Sweden)

    Do-Kwan Hong

    2014-08-01

    Full Text Available The objective of the present study was to deal with the rotordynamics of the rotor of an ultra-high speed PM type synchronous motor-generator for a 500 W rated micro gas turbine generator. This paper introduces dynamic analysis, and experiments on the motor-generator. The focus is placed on an analytical approach considering the mechanical dynamic problems. It is essential to deal with dynamic stability at ultra-high speeds. Unbalance response analysis is performed by calculating the unbalance with and without balancing using a balancing machine. Critical speed analysis is performed to determine the operating speed with sufficient separation margin. The unbalance response analysis is compared with the experimental results considering the balancing grade (ISO 1940-1 and predicted vibration displacement with and without balancing. Based on these results, a high-speed motor-generator was successfully developed.

  3. Unbalance response analysis and experimental validation of an ultra high speed motor-generator for microturbine generators considering balancing.

    Science.gov (United States)

    Hong, Do-Kwan; Joo, Dae-Suk; Woo, Byung-Chul; Koo, Dae-Hyun; Ahn, Chan-Woo

    2014-08-29

    The objective of the present study was to deal with the rotordynamics of the rotor of an ultra-high speed PM type synchronous motor-generator for a 500 W rated micro gas turbine generator. This paper introduces dynamic analysis, and experiments on the motor-generator. The focus is placed on an analytical approach considering the mechanical dynamic problems. It is essential to deal with dynamic stability at ultra-high speeds. Unbalance response analysis is performed by calculating the unbalance with and without balancing using a balancing machine. Critical speed analysis is performed to determine the operating speed with sufficient separation margin. The unbalance response analysis is compared with the experimental results considering the balancing grade (ISO 1940-1) and predicted vibration displacement with and without balancing. Based on these results, a high-speed motor-generator was successfully developed.

  4. Generating Functional Analysis for Iterative CDMA Multiuser Detectors

    CERN Document Server

    Mimura, Kazushi

    2011-01-01

    We investigate the detection dynamics of a soft parallel interference canceller (soft-PIC), which includes a hard-PIC as a special case, for CDMA multiuser detection, applied to a randomly spread, fully synchronous base-band uncoded CDMA channel model with additive white Gaussian noise (AWGN) under perfect power control in the large-system limit. We analyze the detection dynamics of some iterative detectors, namely soft-PIC, the Onsager-reaction-cancelling parallel interference canceller (ORC-PIC) and the belief-propagation(BP)-based detector, by the generating functional analysis (GFA). The GFA allows us to study the asymptotic behavior of the dynamics in the infinitely large system without assuming the independence of messages. We study the detection dynamics and the stationary estimates of an iterative algorithm. We also show the decoupling principle in iterative multiuser detection algorithms in the large-system limit. For a generic iterative multiuser detection algorithm with binary input, it is shown th...

  5. Extending and automating a Systems-Theoretic hazard analysis for requirements generation and analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, John (Massachusetts Institute of Technology)

    2012-05-01

    Systems Theoretic Process Analysis (STPA) is a powerful new hazard analysis method designed to go beyond traditional safety techniques - such as Fault Tree Analysis (FTA) - that overlook important causes of accidents like flawed requirements, dysfunctional component interactions, and software errors. While proving to be very effective on real systems, no formal structure has been defined for STPA and its application has been ad-hoc with no rigorous procedures or model-based design tools. This report defines a formal mathematical structure underlying STPA and describes a procedure for systematically performing an STPA analysis based on that structure. A method for using the results of the hazard analysis to generate formal safety-critical, model-based system and software requirements is also presented. Techniques to automate both the analysis and the requirements generation are introduced, as well as a method to detect conflicts between the safety and other functional model-based requirements during early development of the system.

  6. Factors associated with involvement in nonmetropolitan LGBTQ organizations: Proximity? Generativity? Minority stress? Social location?

    Science.gov (United States)

    Paceley, Megan S; Oswald, Ramona Faith; Hardesty, Jennifer L

    2014-01-01

    Little is known about involvement in LGBTQ organizations. Factors associated with involvement in nonmetropolitan LGBTQ organizations were examined using logistic regression and survey data from 426 LGBTQ individuals residing in a nonmetropolitan region. Involvement was examined in five types of organizations (professional, social/recreational, religious, political, and community center/charity). The same model testing proximity, generativity, minority stress, and social location hypotheses was repeated for each organization type. Results demonstrate that the generativity hypothesis is most strongly supported. Indeed, emotional attachment to the LGBTQ community significantly increased the odds of involvement in every type of organization. However, the factors associated with involvement otherwise differed by organization type. Implications for organizational leaders are discussed.

  7. Learning a generative model of images by factoring appearance and shape.

    Science.gov (United States)

    Le Roux, Nicolas; Heess, Nicolas; Shotton, Jamie; Winn, John

    2011-03-01

    Computer vision has grown tremendously in the past two decades. Despite all efforts, existing attempts at matching parts of the human visual system's extraordinary ability to understand visual scenes lack either scope or power. By combining the advantages of general low-level generative models and powerful layer-based and hierarchical models, this work aims at being a first step toward richer, more flexible models of images. After comparing various types of restricted Boltzmann machines (RBMs) able to model continuous-valued data, we introduce our basic model, the masked RBM, which explicitly models occlusion boundaries in image patches by factoring the appearance of any patch region from its shape. We then propose a generative model of larger images using a field of such RBMs. Finally, we discuss how masked RBMs could be stacked to form a deep model able to generate more complicated structures and suitable for various tasks such as segmentation or object recognition.

  8. Practical Considerations for Using Exploratory Factor Analysis in Educational Research

    Science.gov (United States)

    Beavers, Amy S.; Lounsbury, John W.; Richards, Jennifer K.; Huck, Schuyler W.; Skolits, Gary J.; Esquivel, Shelley L.

    2013-01-01

    The uses and methodology of factor analysis are widely debated and discussed, especially the issues of rotational use, methods of confirmatory factor analysis, and adequate sample size. The variety of perspectives and often conflicting opinions can lead to confusion among researchers about best practices for using factor analysis. The focus of the…

  9. Generation of flat viewing zone in DFVZ autostereoscopic multiview 3D display by weighting factor

    Science.gov (United States)

    Kim, Sung-Kyu; Yoon, Seon-Kyu; Yoon, Ky-Hyuk

    2013-05-01

    A new method is introduced to reduce three crosstalk problems and the brightness variation in 3D image by means of the dynamic fusion of viewing zones (DFVZ) using weighting factor. The new method effectively generates the flat viewing zone at the center of viewing zone. The new type autostereoscopic 3D display can give less brightness variation of 3D image when observer moves.

  10. Generation of hyaline cartilaginous tissue from mouse adult dermal fibroblast culture by defined factors

    Science.gov (United States)

    Hiramatsu, Kunihiko; Sasagawa, Satoru; Outani, Hidetatsu; Nakagawa, Kanako; Yoshikawa, Hideki; Tsumaki, Noriyuki

    2011-01-01

    Repair of cartilage injury with hyaline cartilage continues to be a challenging clinical problem. Because of the limited number of chondrocytes in vivo, coupled with in vitro de-differentiation of chondrocytes into fibrochondrocytes, which secrete type I collagen and have an altered matrix architecture and mechanical function, there is a need for a novel cell source that produces hyaline cartilage. The generation of induced pluripotent stem (iPS) cells has provided a tool for reprogramming dermal fibroblasts to an undifferentiated state by ectopic expression of reprogramming factors. Here, we show that retroviral expression of two reprogramming factors (c-Myc and Klf4) and one chondrogenic factor (SOX9) induces polygonal chondrogenic cells directly from adult dermal fibroblast cultures. Induced cells expressed marker genes for chondrocytes but not fibroblasts, i.e., the promoters of type I collagen genes were extensively methylated. Although some induced cell lines formed tumors when subcutaneously injected into nude mice, other induced cell lines generated stable homogenous hyaline cartilage–like tissue. Further, the doxycycline-inducible induction system demonstrated that induced cells are able to respond to chondrogenic medium by expressing endogenous Sox9 and maintain chondrogenic potential after substantial reduction of transgene expression. Thus, this approach could lead to the preparation of hyaline cartilage directly from skin, without generating iPS cells. PMID:21293062

  11. Quantification of Monte Carlo event generator scale-uncertainties with an example ATLAS analysis studying underlying event properties

    Energy Technology Data Exchange (ETDEWEB)

    Brandt, Gerhard [University of Oxford (United Kingdom); Krauss, Frank [IPPP Durham (United Kingdom); Lacker, Heiko; Leyton, Michael; Mamach, Martin; Schulz, Holger; Weyh, Daniel [Humboldt University of Berlin (Germany)

    2012-07-01

    Monte Carlo (MC) event generators are widely employed in the analysis of experimental data also for LHC in order to predict the features of observables and test analyses with them. These generators rely on phenomenological models containing various parameters which are free in certain ranges. Variations of these parameters relative to their default lead to uncertainties on the predictions of the event generators and, in turn, on the results of any experimental data analysis making use of the event generator. A Generalized method for quantifying a certain class of these generator based uncertainties will be presented in this talk. We study for the SHERPA event generator the effect on the analysis results from uncertainties in the choice of the merging and factorization scale. The quantification is done within an example ATLAS analysis measuring underlying event UE properties in Z-boson production limited to low transverse momenta (p{sub T}{sup Z}<3 GeV) of the Z-boson. The analysis extracts event-shape distributions from charged particles in the event that do not belong to the Z decay for generate Monte Carlo event and data which are unfolded back to the generator level.

  12. The Performance Analysis of Ultra High Speed PM Type Synchronous Motor-Generator for Micro Turbine

    Science.gov (United States)

    Hong, Do-Kwan; Woo, Byung-Chul; Jeong, Yeon-Ho; Koo, Dae-Hyun; Cho, Yun-Hyun

    This paper deals with loss analysis, structural, thermal-fluid and rotordynamics (critical speed and unbalance) which need in developing the motor-generator. This machine has designed of a generator of 800 W, 400 krpm and a starter of 400 W, 200 krpm. The generated losses of motor-generator are derived by magnetic analysis. Thermal-fluid analysis is performed using loss analysis result. The critical speed is extracted by Campbell diagram. Unbalance vibration response analysis enable to predict the expected vibration amplitude by unbalance. The motor-generator is well-developed using the applied several techniques of analysis.

  13. An Economic Analysis of Generation IV Small Modular Reactors

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, J S; Lamont, A D; Rothwell, G S; Smith, C F; Greenspan, E; Brown, N; Barak, A

    2002-03-01

    This report examines some conditions necessary for Generation IV Small Modular Reactors (SMRs) to be competitive in the world energy market. The key areas that make nuclear reactors an attractive choice for investors are reviewed, and a cost model based on the ideal conditions is developed. Recommendations are then made based on the output of the cost model and on conditions and tactics that have proven successful in other industries. The Encapsulated Nuclear Heat Source (ENHS), a specific SMR design concept, is used to develop the cost model and complete the analysis because information about the ENHS design is readily available from the University of California at Berkeley Nuclear Engineering Department. However, the cost model can be used to analyze any of the current SMR designs being considered. On the basis of our analysis, we determined that the nuclear power industry can benefit from and SMRs can become competitive in the world energy market if a combination of standardization and simplification of orders, configuration, and production are implemented. This would require wholesale changes in the way SMRs are produced, manufactured and regulated, but nothing that other industries have not implemented and proven successful.

  14. Generating Property-Directed Potential Invariants By Backward Analysis

    Directory of Open Access Journals (Sweden)

    Adrien Champion

    2012-12-01

    Full Text Available This paper addresses the issue of lemma generation in a k-induction-based formal analysis of transition systems, in the linear real/integer arithmetic fragment. A backward analysis, powered by quantifier elimination, is used to output preimages of the negation of the proof objective, viewed as unauthorized states, or gray states. Two heuristics are proposed to take advantage of this source of information. First, a thorough exploration of the possible partitionings of the gray state space discovers new relations between state variables, representing potential invariants. Second, an inexact exploration regroups and over-approximates disjoint areas of the gray state space, also to discover new relations between state variables. k-induction is used to isolate the invariants and check if they strengthen the proof objective. These heuristics can be used on the first preimage of the backward exploration, and each time a new one is output, refining the information on the gray states. In our context of critical avionics embedded systems, we show that our approach is able to outperform other academic or commercial tools on examples of interest in our application field. The method is introduced and motivated through two main examples, one of which was provided by Rockwell Collins, in a collaborative formal verification framework.

  15. Generation of Leukemia Inhibitory Factor-Dependent Induced Pluripotent Stem Cells from the Massachusetts General Hospital Miniature Pig

    Directory of Open Access Journals (Sweden)

    Dae-Jin Kwon

    2013-01-01

    Full Text Available The generation and application of porcine induced pluripotent stem cells (iPSCs may enable the testing for safety and efficacy of therapy in the field of human regenerative medicine. Here, the generation of iPSCs from the Massachusetts General Hospital miniature pig (MGH minipig established for organ transplantation studies is reported. Fibroblasts were isolated from the skin of the ear of a 10-day-old MGH minipig and transduced with a cocktail of six human factors: POU5F1, NANOG, SOX2, C-MYC, KLF4, and LIN28. Two distinct types of iPSCs were generated that were positive for alkaline phosphatase activity, as well as the classical pluripotency markers: Oct4, Nanog, Sox2, and the surface marker Ssea-1. Only one of two porcine iPSC lines differentiated into three germ layers both in vitro and in vivo. Western blot analysis showed that the porcine iPSCs were dependent on LIF or BMP-4 to sustain self-renewal and pluripotency. In conclusion, the results showed that human pluripotent factors could reprogram porcine ear fibroblasts into the pluripotent state. These cells may provide a useful source of cells that could be used for the treatment of degenerative and genetic diseases and agricultural research and application.

  16. Performance analysis of next-generation lunar laser retroreflectors

    Science.gov (United States)

    Ciocci, Emanuele; Martini, Manuele; Contessa, Stefania; Porcelli, Luca; Mastrofini, Marco; Currie, Douglas; Delle Monache, Giovanni; Dell'Agnello, Simone

    2017-09-01

    ) to GR tests and to constraints on new gravitational theories (like non-minimally coupled gravity and spacetime torsion), the description of the associated physics analysis and global LLR error budget is outside of the chosen scope of present paper. We note that, according to Reasenberg et al. (2016), software models used for LLR physics and lunar science cannot process residuals with an accuracy better than few centimeters and that, in order to process millimeter ranging data (or better) coming from (not only) future reflectors, it is necessary to update and improve the respective models inside the software package. The work presented here on results of the SCF-test thermal and optical analysis shows that a good performance is expected by MoonLIGHT-2 after its deployment on the Moon. This in turn will stimulate improvements in LLR ground segment hardware and help refine the LLR software code and models. Without a significant improvement of the LLR space segment, the acquisition of improved ground LLR hardware and challenging LLR software refinements may languish for lack of motivation, since the librations of the old generation LLR payloads largely dominate the global LLR error budget.

  17. Analysis of students’ generated questions in laboratory learning environments

    Directory of Open Access Journals (Sweden)

    Juan Antonio Llorens-Molina

    2012-03-01

    Full Text Available In order to attain a reliable laboratory work assessment, we argue taking the Learning Environment as a core concept and a research paradigm that considers the factors affecting the laboratory as a particularly complex educational context. With regard to Laboratory Learning Environments (LLEs, a well known approach is the SLEI (Science Laboratory Environment Inventory. The aim of this research is to design and apply an alternative and qualitative assessment tool to characterize Laboratory Learning Environments in an introductory course of organic chemistry. An alternative and qualitative assessment tool would be useful for providing feed-back for experimental learning improvement; serving as a complementary triangulation tool in educational research on LLEs; and generating meaningful categories in order to design quantitative research instruments. Toward this end, spontaneous questions by students have been chosen as a reliable source of information. To process these questions, a methodology based on the Grounded Theory has been developed to provide a framework for characterizing LLEs. This methodology has been applied in two case studies. The conclusions lead us to argue for using more holistic assessment tools in both everyday practice and research. Likewise, a greater attention should be paid to metacognition to achieve suitable self-perception concerning students’ previous knowledge and manipulative skills.

  18. Improvement of force factor of magnetostrictive vibration power generator for high efficiency

    Energy Technology Data Exchange (ETDEWEB)

    Kita, Shota, E-mail: happiest3.7@gmail.com; Ueno, Toshiyuki; Yamada, Sotoshi [Kanazawa University, Kakuma-machi, Kanazawa-city, Ishikawa 920-1164 (Japan)

    2015-05-07

    We develop high power magnetostrictive vibration power generator for battery-free wireless electronics. The generator is based on a cantilever of parallel beam structure consisting of coil-wound Galfenol and stainless plates with permanent magnet for bias. Oscillating force exerted on the tip bends the cantilever in vibration yields stress variation of Galfenol plate, which causes flux variation and generates voltage on coil due to the law of induction. This generator has advantages over conventional, such as piezoelectric or moving magnet types, in the point of high efficiency, highly robust, and low electrical impedance. Our concern is the improvement of energy conversion efficiency dependent on the dimension. Especially, force factor, the conversion ratio of the electromotive force (voltage) on the tip velocity in vibration, has an important role in energy conversion process. First, the theoretical value of the force factor is formulated and then the validity was verified by experiments, where we compare four types of prototype with parameters of the dimension using 7.0 × 1.5 × 50 mm beams of Galfenol with 1606-turn wound coil. In addition, the energy conversion efficiency of the prototypes depending on load resistance was measured. The most efficient prototype exhibits the maximum instantaneous power of 0.73 W and energy of 4.7 mJ at a free vibration of frequency of 202 Hz in the case of applied force is 25 N. Further, it was found that energy conversion efficiency depends not only on the force factor but also on the damping (mechanical loss) of the vibration.

  19. Generation and Quality Analysis of Greywater at Dhaka City

    Directory of Open Access Journals (Sweden)

    Shaikha Binte Abedin

    2013-07-01

    Full Text Available One of the natural resources available in nature is water; however, it is not readily available for domestic use for millions of people across the globe. An increasing global population coupled with growing urbanization worldwide has led to increased demands on water supply. The rapid growth of water-intensive agriculture in developing countries and inefficient water management practices in the developed world are contributing to a global reduction in future freshwater supplies. The world is currently in the midst of cross roads where the unsustainable and impractical uses of water are no longer acceptable. The recycling and reuse of water is therefore imperative in some areas, and increasingly such in the others to meet the demands for urban, industrial and agricultural water requirements. Greywater, which can be defined as all in-building wastewater streams with an exception of toilet wastewater, is a potential water source for urban reuse, as it contains a few or no pathogens and 90 percent less nitrogen than blackwater. This study reveals the generation and quality of greywater in Dhaka City. The groundwater level is depleting by 2/3 of a meter per year in Dhaka. Thus, the recycling and reuse of water have become imperative to meet the demand for it. To analyze the generation of greywater in Dhaka City, water use in five households has been studied and about 67% of water was found to be reusable, whereas about 17% of potable water was wasted in toilet flushing. From the quality analysis, kitchen water was found to be polluted to some degree, and judging by its quality, it should not be reused. Greywater must be treated before any kind of reuse as it exceeds the standards of the acceptable quality of potable water and irrigation water.DOI: http://dx.doi.org/10.5755/j01.erem.64.2.3992

  20. An economic analysis of the electricity generation potential from biogas resources in the state of Indiana

    Science.gov (United States)

    Giraldo, Juan S.

    Anaerobic digestion is a process that is a common part of organic waste management systems and is used in concentrated animal feeding operations (CAFOs), wastewater treatment plants (WWTPs), and municipal solid waste (MSW) landfills. The process produces biogas, which contains methane, and it can be burned to generate electricity. Previous reports have indicated that based on the availability of feedstocks there is a large potential for biogas production and use for electricity generation in the state of Indiana. However, these reports varied in their consideration of important factors that affect the technical and economic feasibility of being able to develop the resources available. The goal of this thesis is to make a more targeted assessment of the electricity generation potential from biogas resources at CAFOs, WWTPs, and MSW landfills in Indiana. A capital budgeting model is used to estimate the net present value (NPV) of biogas electricity projects at facilities that are identified as technically suitable. A statewide estimate of the potential generation capacity is made by estimating the number of facilities that could profitably undertake a biogas electricity project. In addition this thesis explored the impact that different incentive policies would have on the economic viability of these projects. The results indicated that the electricity generation potential is much smaller when technical and economic factors are taken into account in addition to feedstock availability. In particular it was found that projects at hog farms are unlikely to be economically feasible in the present even when financial incentives are considered. In total, 47.94 MW of potential generating capacity is estimated from biogas production at CAFOs, WWTPs, and MSW landfills. Though results indicated that 37.10 MW of capacity are economically feasible under current operating conditions, sensitivity analysis reveals that these projects are very sensitive to capital cost assumptions

  1. Thermal mechanical analysis of applications with internal heat generation

    Science.gov (United States)

    Govindarajan, Srisharan Garg

    control blade, spatial variations in temperature within the control blade occur from the non-uniform heat generation within the BORAL as a result of the non-uniform thermal neutron flux along the longitudinal direction when the control blade is partially withdrawn. There is also variation in the heating profile through the thickness and about the circumferential width of the control blade. Mathematical curve-fits are generated for the non-uniform volumetric heat generation profile caused by the thermal neutron absorption and the functions are applied as heating conditions within a finite element model of the control blade built using the commercial finite element code Abaqus FEA. The finite element model is solved as a fully coupled thermal mechanical problem as in the case of the annular target. The resulting deflection is compared with the channel gap to determine if there is a significant risk of the control blade binding during reactor operation. Hence, this dissertation will consist of two sections. The first section will seek to present the thermal and structural safety analyses of the annular targets for the production of molybdenum-99. Since there hasn't been any detailed, documented, study on these annular targets in the past, the work complied in this dissertation will help to understand the thermal-mechanical behavior and failure margins of the target during in-vessel irradiation. As the work presented in this dissertation provides a general performance analysis envelope for the annular target, the tools developed in the process can also be used as useful references for future analyses that are specific to any reactor. The numerical analysis approach adopted and the analytical models developed, can also be applied to other applications, outside the Mo-99 project domain, where internal heat generation exists such as in electronic components and nuclear reactor control blades. The second section will focus on estimating the thermally induced deflection and hence

  2. PERCEPTIONS ON CONFLICTS AMONG GENERATIONS IN WORKPLACE: A BRIEF ANALYSIS OF BABY BOOMERS AND SUBSEQUENT GENERATIONS

    Directory of Open Access Journals (Sweden)

    Isabel Cristina dos Santos

    2015-09-01

    Full Text Available A generation is the entire group of individuals born and living at about the same time. Their children characterize a new generation (justified biologically and socially for about a period of 25 years and so forth. Members of the same generation - excluding differences in their social and economic status - would have similar habits, behaviors and aspirations. Generations would carry on themselves the traces of their time. However, because of the exponential advance in technology, especially communication, information and transportation, it is estimated that new generations are formed every ten years, which creates a considerable difference on the perception of role, attitude and commitment in work environment, amongst leaders and followers. This difference is a potential source of conflicts. This article aims to identify the different views of attributes, perceptions and values of each generation. It is an exploratory research and it uses questionnaires applied via social networking websites. The results show subtle differences amongst generations, which, not necessarily indicate conflicts. It is observed that the commitment and fidelity to work are unaltered as a value for the professionals.

  3. Housing price forecastability: A factor analysis

    DEFF Research Database (Denmark)

    Bork, Lasse; Møller, Stig Vinther

    of the model stays high at longer horizons. The estimated factors are strongly statistically signi…cant according to a bootstrap resampling method which takes into account that the factors are estimated regressors. The simple three-factor model also contains substantial out-of-sample predictive power...

  4. Theory of sampling: four critical success factors before analysis.

    Science.gov (United States)

    Wagner, Claas; Esbensen, Kim H

    2015-01-01

    Food and feed materials characterization, risk assessment, and safety evaluations can only be ensured if QC measures are based on valid analytical data, stemming from representative samples. The Theory of Sampling (TOS) is the only comprehensive theoretical framework that fully defines all requirements to ensure sampling correctness and representativity, and to provide the guiding principles for sampling in practice. TOS also defines the concept of material heterogeneity and its impact on the sampling process, including the effects from all potential sampling errors. TOS's primary task is to eliminate bias-generating errors and to minimize sampling variability. Quantitative measures are provided to characterize material heterogeneity, on which an optimal sampling strategy should be based. Four critical success factors preceding analysis to ensure a representative sampling process are presented here.

  5. Social and cultural factors underlying generational differences in overweight: a cross-sectional study among ethnic minorities in the Netherlands

    OpenAIRE

    Nierkens Vera; van Valkengoed Irene; Nicolaou Mary; Hosper Karen; Stronks Karien

    2011-01-01

    Abstract Background The prevalence of overweight appears to vary in people of first and second generation ethnic minority groups. Insight into the factors that underlie these weight differences might help in understanding the health transition that is taking place across generations following migration. We studied the role of social and cultural factors associated with generational differences in overweight among young Turkish and Moroccan men and women in the Netherlands. Methods Cross-secti...

  6. Development of net energy ratio and emission factor for quad-generation pathways

    DEFF Research Database (Denmark)

    Rudra, Souman; Rosendahl, Lasse; Kumar, Amit

    2014-01-01

    of this study was to evaluate the energy performance, reduce GHG and acid rain precursor emission, and use of biomass for different outputs based on demand. Finally, a sensitivity analysis and a comparative study ar conducted for expected technological improvements and factors that could increase the energy...

  7. Numerical analysis of flow fields generated by accelerating flames

    Energy Technology Data Exchange (ETDEWEB)

    Kurylo, J.

    1977-12-01

    Presented here is a numerical technique for the analysis of non-steady flow fields generated by accelerating flames in gaseous media. Of particular interest in the study is the evaluation of the non-steady effects on the flow field and the possible transition of the combustion process to detonation caused by an abrupt change in the burning speed of an initially steady flame propagating in an unconfined combustible gas mixture. Optically recorded observations of accelerating flames established that the flow field can be considered to consist of non-steady flow fields associated with an assembly of interacting shock waves, contact discontinuities, deflagration and detonation fronts. In the analysis, these flow fields are treated as spatially one-dimensional, the influence of transport phenomena is considered to be negligible, and unburned and burned substances are assumed to behave as perfect gases with constant, but different, specific heats. The basis of the numerical technique is an explicit, two step, second order accurate, finite difference scheme employed to integrate the flow field equations expressed in divergence form. The burning speed, governing the motion of the deflagration, is expressed in the form of a power law dependence on pressure and temperature immediately ahead of its front. The steady wave solution is obtained by the vector polar interaction technique, that is, by determining the point of intersection between the loci of end states in the plane of the two interaction invariants, pressure and particle velocity. The technique is illustrated by a numerical example in which a steady flame experiences an abrupt change in its burning speed. Solutions correspond either to the eventual reestablishment of a steady state flow field commensurate with the burning speed or to the transition to detonation. The results are in satisfactory agreement with experimental observations.

  8. Wind Power predictability a risk factor in the design, construction and operation of Wind Generation Turbines

    Science.gov (United States)

    Thiesen, J.; Gulstad, L.; Ristic, I.; Maric, T.

    2010-09-01

    Summit: The wind power predictability is often a forgotten decision and planning factor for most major wind parks, both onshore and offshore. The results of the predictability are presented after having examined a number of European offshore and offshore parks power predictability by using three(3) mesoscale model IRIE_GFS and IRIE_EC and WRF. Full description: It is well known that the potential wind production is changing with latitude and complexity in terrain, but how big are the changes in the predictability and the economic impacts on a project? The concept of meteorological predictability has hitherto to some degree been neglected as a risk factor in the design, construction and operation of wind power plants. Wind power plants are generally built in places where the wind resources are high, but these are often also sites where the predictability of the wind and other weather parameters is comparatively low. This presentation addresses the question of whether higher predictability can outweigh lower average wind speeds with regard to the overall economy of a wind power project. Low predictability also tends to reduce the value of the energy produced. If it is difficult to forecast the wind on a site, it will also be difficult to predict the power production. This, in turn, leads to increased balance costs and a less reduced carbon emission from the renewable source. By investigating the output from three(3) mesoscale models IRIE and WRF, using ECMWF and GFS as boundary data over a forecasting period of 3 months for 25 offshore and onshore wind parks in Europe, the predictability are mapped. Three operational mesoscale models with two different boundary data have been chosen in order to eliminate the uncertainty with one mesoscale model. All mesoscale models are running in a 10 km horizontal resolution. The model output are converted into "day a head" wind turbine generation forecasts by using a well proven advanced physical wind power model. The power models

  9. Generation of primitive neural stem cells from human fibroblasts using a defined set of factors

    Directory of Open Access Journals (Sweden)

    Takumi Miura

    2015-11-01

    Full Text Available In mice, leukemia inhibitory factor (LIF-dependent primitive neural stem cells (NSCs have a higher neurogenic potential than bFGF-dependent definitive NSCs. Therefore, expandable primitive NSCs are required for research and for the development of therapeutic strategies for neurological diseases. There is a dearth of suitable techniques for the generation of human long-term expandable primitive NSCs. Here, we have described a method for the conversion of human fibroblasts to LIF-dependent primitive NSCs using a strategy based on techniques for the generation of induced pluripotent stem cells (iPSCs. These LIF-dependent induced NSCs (LD-iNSCs can be expanded for >100 passages. Long-term cultured LD-iNSCs demonstrated multipotent neural differentiation potential and could generate motor neurons and dopaminergic neurons, as well as astrocytes and oligodendrocytes, indicating a high level of plasticity. Furthermore, LD-iNSCs easily reverted to human iPSCs, indicating that LD-iNSCs are in an intermediate iPSC state. This method may facilitate the generation of patient-specific human neurons for studies and treatment of neurodegenerative diseases.

  10. Nuclear data evaluation and group constant generation for reactor analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jung Doh; Kil, Chung Sub [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1994-12-01

    Data testing of ENDF/B-VI.2 was performed and ACE-format continuous point-wise cross section library from ENDF/B-VI.2 for MCNP was validated through CSEWG benchmark and power plant mockup experiments. The calculated k-effective of ORNL-1, -2, -3, -4 and -10 with ENDF/B-VI are low by about 0.5% but those of L-7, -8, -9, -10 and -11 show good agreement with experiments. Overall results for uranium core with ENDF/B-VI is low in critically than with ENDF/B-V. The calculated results with ENDF/B-VI for PNL-6 {approx} 12 of plutonium core and PNL-30 {approx} 35 of mixed oxide core show good agreement with the experiments. The results of critically calculation for fast core benchmark do not show large difference between ENDF/B-VI and -V. But the calculated results of reaction rate ratio with ENDF/B-VI are improved, compared with ENDF/B-V. The calculated power distribution for VENUS PWR mockup core and typical BWR core of GE with both of ENDF/B-VI and -V agree well with measured values. From the above results, newly generated MCNP library from ENDF/B-VI is useful for nuclear and shielding design and analysis. 5 figs, 13 tabs, 11 refs. (Author).

  11. Solar Electric Generating System II finite element analysis

    Energy Technology Data Exchange (ETDEWEB)

    Dohner, J.L.; Anderson, J.R.

    1994-04-01

    On June 2, 1992, Landers` earthquake struck the Solar Electric Generating System II, located in Daggett, California. The 30 megawatt power station, operated by the Daggett Leasing Corporation (DLC), suffered substantial damage due to structural failures in the solar farm. These failures consisted of the separation of sliding joints supporting a distribution of parabolic glass mirrors. At separation, the mirrors fell to the ground and broke. It was the desire of the DLC and the Solar Thermal Design Assistance Center (STDAC) of Sandia National Laboratories (SNL) and to redesign these joints so that, in the event of future quakes, costly breakage will be avoided. To accomplish this task, drawings of collector components were developed by the STDAC, from which a detailed finite element computer model of a solar collector was produced. This nonlinear dynamic model, which consisted of over 8,560 degrees of freedom, underwent model reduction to form a low order nonlinear dynamic model containing only 40 degrees of freedom. This model was then used as a design tool to estimate joint dynamics. Using this design tool, joint configurations were modified, and an acceptable joint redesign determined. The results of this analysis showed that the implementation of metal stops welded to support shafts for the purpose of preventing joint separation is a suitable joint redesign. Moreover, it was found that, for quakes of Landers` magnitude, mirror breakage due to enhanced vibration in the trough assembly is unlikely.

  12. PANGEA: pipeline for analysis of next generation amplicons.

    Science.gov (United States)

    Giongo, Adriana; Crabb, David B; Davis-Richardson, Austin G; Chauliac, Diane; Mobberley, Jennifer M; Gano, Kelsey A; Mukherjee, Nabanita; Casella, George; Roesch, Luiz F W; Walts, Brandon; Riva, Alberto; King, Gary; Triplett, Eric W

    2010-07-01

    High-throughput DNA sequencing can identify organisms and describe population structures in many environmental and clinical samples. Current technologies generate millions of reads in a single run, requiring extensive computational strategies to organize, analyze and interpret those sequences. A series of bioinformatics tools for high-throughput sequencing analysis, including pre-processing, clustering, database matching and classification, have been compiled into a pipeline called PANGEA. The PANGEA pipeline was written in Perl and can be run on Mac OSX, Windows or Linux. With PANGEA, sequences obtained directly from the sequencer can be processed quickly to provide the files needed for sequence identification by BLAST and for comparison of microbial communities. Two different sets of bacterial 16S rRNA sequences were used to show the efficiency of this workflow. The first set of 16S rRNA sequences is derived from various soils from Hawaii Volcanoes National Park. The second set is derived from stool samples collected from diabetes-resistant and diabetes-prone rats. The workflow described here allows the investigator to quickly assess libraries of sequences on personal computers with customized databases. PANGEA is provided for users as individual scripts for each step in the process or as a single script where all processes, except the chi(2) step, are joined into one program called the 'backbone'.

  13. Accelerating next generation sequencing data analysis with system level optimizations.

    Science.gov (United States)

    Kathiresan, Nagarajan; Temanni, Ramzi; Almabrazi, Hakeem; Syed, Najeeb; Jithesh, Puthen V; Al-Ali, Rashid

    2017-08-22

    Next generation sequencing (NGS) data analysis is highly compute intensive. In-memory computing, vectorization, bulk data transfer, CPU frequency scaling are some of the hardware features in the modern computing architectures. To get the best execution time and utilize these hardware features, it is necessary to tune the system level parameters before running the application. We studied the GATK-HaplotypeCaller which is part of common NGS workflows, that consume more than 43% of the total execution time. Multiple GATK 3.x versions were benchmarked and the execution time of HaplotypeCaller was optimized by various system level parameters which included: (i) tuning the parallel garbage collection and kernel shared memory to simulate in-memory computing, (ii) architecture-specific tuning in the PairHMM library for vectorization, (iii) including Java 1.8 features through GATK source code compilation and building a runtime environment for parallel sorting and bulk data transfer (iv) the default 'on-demand' mode of CPU frequency is over-clocked by using 'performance-mode' to accelerate the Java multi-threads. As a result, the HaplotypeCaller execution time was reduced by 82.66% in GATK 3.3 and 42.61% in GATK 3.7. Overall, the execution time of NGS pipeline was reduced to 70.60% and 34.14% for GATK 3.3 and GATK 3.7 respectively.

  14. Radiotherapy treatment planning with dynamic wedges--an algorithm for generating wedge factors and beam data.

    Science.gov (United States)

    Thomas, S J; Foster, K R

    1995-09-01

    If the jaws of a linear accelerator are moved under computer control during irradiation, dose distributions similar to those with wedge filters can be produced. Varian linear accelerators utilize this effect to give a 'dynamic wedge', using segmented treatment tables (STTs). An algorithm is described to generate the dose per monitor unit at any point in a beam, using the STT values. Dynamically wedged beams are modelled as the superposition of static asymmetric beams, using an algorithm based on beam data measured for symmetric beams. Predictions of wedge factors, depth doses and profiles generated using the algorithm are compared with measurements. Good agreement is found between predictions and measurements. The calculation time is typically 5 ms/dose point on a PC with a 486DX processor.

  15. A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets.

    Science.gov (United States)

    Scoville, Steven D; Mundy-Bosse, Bethany L; Zhang, Michael H; Chen, Li; Zhang, Xiaoli; Keller, Karen A; Hughes, Tiffany; Chen, Luxi; Cheng, Stephanie; Bergin, Stephen M; Mao, Hsiaoyin C; McClory, Susan; Yu, Jianhua; Carson, William E; Caligiuri, Michael A; Freud, Aharon G

    2016-05-17

    The current model of murine innate lymphoid cell (ILC) development holds that mouse ILCs are derived downstream of the common lymphoid progenitor through lineage-restricted progenitors. However, corresponding lineage-restricted progenitors in humans have yet to be discovered. Here we identified a progenitor population in human secondary lymphoid tissues (SLTs) that expressed the transcription factor RORγt and was unique in its ability to generate all known ILC subsets, including natural killer (NK) cells, but not other leukocyte populations. In contrast to murine fate-mapping data, which indicate that only ILC3s express Rorγt, these human progenitor cells as well as human peripheral blood NK cells and all mature ILC populations expressed RORγt. Thus, all human ILCs can be generated through an RORγt(+) developmental pathway from a common progenitor in SLTs. These findings help establish the developmental signals and pathways involved in human ILC development.

  16. Generating pedestrian trajectories consistent with the fundamental diagram based on physiological and psychological factors.

    Directory of Open Access Journals (Sweden)

    Sahil Narang

    Full Text Available Pedestrian crowds often have been modeled as many-particle system including microscopic multi-agent simulators. One of the key challenges is to unearth governing principles that can model pedestrian movement, and use them to reproduce paths and behaviors that are frequently observed in human crowds. To that effect, we present a novel crowd simulation algorithm that generates pedestrian trajectories that exhibit the speed-density relationships expressed by the Fundamental Diagram. Our approach is based on biomechanical principles and psychological factors. The overall formulation results in better utilization of free space by the pedestrians and can be easily combined with well-known multi-agent simulation techniques with little computational overhead. We are able to generate human-like dense crowd behaviors in large indoor and outdoor environments and validate the results with captured real-world crowd trajectories.

  17. Oxidatively generated base modifications in DNA: Not only carcinogenic risk factor but also regulatory mark?

    Science.gov (United States)

    Seifermann, Marco; Epe, Bernd

    2017-06-01

    The generation of DNA modifications in cells is in most cases accidental and associated with detrimental consequences such as increased mutation rates and an elevated risk of malignant transformation. Accordingly, repair enzymes involved in the removal of the modifications have primarily a protective function. Among the well-established exceptions of this rule are 5-methylcytosine and uracil, which are generated in DNA enzymatically under controlled conditions and fulfill important regulatory functions in DNA as epigenetic marks and in antibody diversification, respectively. More recently, considerable evidence has been obtained that also 8-oxo-7,8-dihydroguanine (8-oxoG), a frequent pro-mutagenic DNA modification generated by endogenous or exogenous reactive oxygen species (ROS), has distinct roles in the regulation of both transcription and signal transduction. Thus, the activation of transcription by the estrogen receptor, NF-κB, MYC and other transcription factors was shown to depend on the presence of 8-oxoG in the promoter regions and its recognition by the DNA repair glycosylase OGG1. The lysine-specific histone demethylase LSD1, which produces H2O2 as a by-product, was indentified as a local generator of 8-oxoG in some of these cases. In addition, a complex of OGG1 with the excised free substrate base was demonstrated to act as a guanine nucleotide exchange factor (GEF) for small GTPases such as Ras, Rac and Rho, thus stimulating signal transduction. The various findings and intriguing novel mechanisms suggested will be described and compared in this review. Copyright © 2017 Elsevier Inc. All rights reserved.

  18. Theoretical analysis of ozone generation by pulsed dielectric barrier discharge in oxygen

    Science.gov (United States)

    Wei, L. S.; Zhou, J. H.; Wang, Z. H.; Cen, K. F.

    2007-08-01

    The use of very short high-voltage pulses combined with a dielectric layer results in high-energy electrons that dissociate oxygen molecules into atoms, which are a prerequisite for the subsequent production of ozone by collisions with oxygen molecules and third particles. The production of ozone depends on both the electrical and the physical parameters. For ozone generation by pulsed dielectric barrier discharge in oxygen, a mathematical model, which describes the relation between ozone concentration and these parameters that are of importance in its design, is developed according to dimensional analysis theory. A formula considering the ozone destruction factor is derived for predicting the characteristics of the ozone generation, within the range of the corona inception voltage to the gap breakdown voltage. The trend showing the dependence of the concentration of ozone in oxygen on these parameters generally agrees with the experimental results, thus confirming the validity of the mathematical model.

  19. Inhibition of tissue factor pathway inhibitor increases the sensitivity of thrombin generation assay to procoagulant microvesicles.

    Science.gov (United States)

    Gheldof, Damien; Mullier, François; Chatelain, Bernard; Dogné, Jean-Michel; Chatelain, Christian

    2013-07-01

    Patients with cancer have a seven-fold to 10-fold increased risk of developing venous thromboembolism (VTE). Circulating microvesicles could be a predictive biomarker for VTE in cancer. Thrombin generation assay (TGA) is a useful technique to detect procoagulant activity of microvesicles. However, TGA suffers from a lack of sensitivity due to the presence of tissue factor pathway inhibitor (TFPI) in plasma. The aim of the study was to improve the sensitivity of TGA to tissue factor by limiting the interference of TFPI. Serial dilutions of MDA-MB231 cells were incubated for 45 min at 37°C to generate microvesicles. Samples were then centrifuged and supernatants that contain microvesicles were used for TGA. Normal pooled plasma was incubated with inhibitor of TFPI or was diluted twice to decrease plasma level of TFPI. Lagtime was used as a surrogate marker of TGA to detect procoagulant activity of microvesicles. Inhibition of TFPI decreased twice the cell concentration needed for a significant reduction of lagtime and decreased 2.4-fold the intraassay variability. Plasma dilution had no impact on the TGA sensitivity when TGA was triggered by microvesicles derived from MDA-MB-231. Thrombin generation is a very sensitive method to study the procoagulant activity of tissue factor bearing microvesicles. The sensitivity can be increased by inhibition of TFPI with specific monoclonal antibody against its Kunitz domain I. A two times plasma dilution is an interesting cheaper alternative to study the procoagulant activity of microvesicles by TGA with a good sensitivity, especially when low plasma quantities are available.

  20. Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach.

    Directory of Open Access Journals (Sweden)

    Katharina Debowski

    Full Text Available Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. The resulting pluripotent cells, called induced pluripotent stem (iPS cells, could be an alternative to embryonic stem cells, which are under continuous ethical debate. Hence, iPS cell-derived functional cells such as neurons may become the key for an effective treatment of currently incurable degenerative diseases. However, besides the requirement of efficacy testing of the therapy also its long-term safety needs to be carefully evaluated in settings mirroring the clinical situation in an optimal way. In this context, we chose the long-lived common marmoset monkey (Callithrix jacchus as a non-human primate species to generate iPS cells. The marmoset monkey is frequently used in biomedical research and is gaining more and more preclinical relevance due to the increasing number of disease models. Here, we describe, to our knowledge, the first-time generation of marmoset monkey iPS cells from postnatal skin fibroblasts by non-viral means. We used the transposon-based, fully reversible piggyback system. We cloned the marmoset monkey reprogramming factors and established robust and reproducible reprogramming protocols with a six-factor-in-one-construct approach. We generated six individual iPS cell lines and characterized them in comparison with marmoset monkey embryonic stem cells. The generated iPS cells are morphologically indistinguishable from marmoset ES cells. The iPS cells are fully reprogrammed as demonstrated by differentiation assays, pluripotency marker expression and transcriptome analysis. They are stable for numerous passages (more than 80 and exhibit euploidy. In summary, we have established efficient non-viral reprogramming protocols for the derivation of stable marmoset monkey iPS cells, which can be used to develop and test cell replacement

  1. Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach.

    Science.gov (United States)

    Debowski, Katharina; Warthemann, Rita; Lentes, Jana; Salinas-Riester, Gabriela; Dressel, Ralf; Langenstroth, Daniel; Gromoll, Jörg; Sasaki, Erika; Behr, Rüdiger

    2015-01-01

    Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. The resulting pluripotent cells, called induced pluripotent stem (iPS) cells, could be an alternative to embryonic stem cells, which are under continuous ethical debate. Hence, iPS cell-derived functional cells such as neurons may become the key for an effective treatment of currently incurable degenerative diseases. However, besides the requirement of efficacy testing of the therapy also its long-term safety needs to be carefully evaluated in settings mirroring the clinical situation in an optimal way. In this context, we chose the long-lived common marmoset monkey (Callithrix jacchus) as a non-human primate species to generate iPS cells. The marmoset monkey is frequently used in biomedical research and is gaining more and more preclinical relevance due to the increasing number of disease models. Here, we describe, to our knowledge, the first-time generation of marmoset monkey iPS cells from postnatal skin fibroblasts by non-viral means. We used the transposon-based, fully reversible piggyback system. We cloned the marmoset monkey reprogramming factors and established robust and reproducible reprogramming protocols with a six-factor-in-one-construct approach. We generated six individual iPS cell lines and characterized them in comparison with marmoset monkey embryonic stem cells. The generated iPS cells are morphologically indistinguishable from marmoset ES cells. The iPS cells are fully reprogrammed as demonstrated by differentiation assays, pluripotency marker expression and transcriptome analysis. They are stable for numerous passages (more than 80) and exhibit euploidy. In summary, we have established efficient non-viral reprogramming protocols for the derivation of stable marmoset monkey iPS cells, which can be used to develop and test cell replacement therapies in

  2. Generation of mouse ES cell lines engineered for the forced induction of transcription factors

    OpenAIRE

    Correa-Cerro, Lina S.; Piao, Yulan; Sharov, Alexei A; Nishiyama, Akira; Cadet, Jean S.; Yu, Hong; Sharova, Lioudmila V.; Xin, Li; Hoang, Hien G.; Thomas, Marshall; Qian, Yong; Dudekula, Dawood B.; Meyers, Emily; Binder, Bernard Y.; Mowrer, Gregory

    2011-01-01

    Here we report the generation and characterization of 84 mouse ES cell lines with doxycycline-controllable transcription factors (TFs) which, together with the previous 53 lines, cover 7–10% of all TFs encoded in the mouse genome. Global gene expression profiles of all 137 lines after the induction of TFs for 48 hrs can associate each TF with the direction of ES cell differentiation, regulatory pathways, and mouse phenotypes. These cell lines and microarray data provide building blocks for a ...

  3. Generation of mouse ES cell lines engineered for the forced induction of transcription factors

    Science.gov (United States)

    Correa-Cerro, Lina S.; Piao, Yulan; Sharov, Alexei A.; Nishiyama, Akira; Cadet, Jean S.; Yu, Hong; Sharova, Lioudmila V.; Xin, Li; Hoang, Hien G.; Thomas, Marshall; Qian, Yong; Dudekula, Dawood B.; Meyers, Emily; Binder, Bernard Y.; Mowrer, Gregory; Bassey, Uwem; Longo, Dan L.; Schlessinger, David; Ko, Minoru S. H.

    2011-01-01

    Here we report the generation and characterization of 84 mouse ES cell lines with doxycycline-controllable transcription factors (TFs) which, together with the previous 53 lines, cover 7–10% of all TFs encoded in the mouse genome. Global gene expression profiles of all 137 lines after the induction of TFs for 48 hrs can associate each TF with the direction of ES cell differentiation, regulatory pathways, and mouse phenotypes. These cell lines and microarray data provide building blocks for a variety of future biomedical research applications as a community resource. PMID:22355682

  4. A Survey of Combat Models for Use in CARF (Combat Active Replacement Factor) Value Generation

    Science.gov (United States)

    1985-03-01

    requirements for the degree of MASTER OF SCIENCE IN CPERATIONS RESEARCH from the NAVAL POSTGRADUATE SCHOOL darch 1985 Author: tv Approved by :... - n Z ...GENERATION OF A WARTIME ACTIVE REPLACEMENT FACTOR (WARF) 65 A. THE PREPROCESSER ................. 66 B. THE COMBAT SAMPLE GEERATOR (COSAGE) MODEL 66 C. THE...en -T,, , -T T L T 17, V 7777% T -T T K 97 7 Ř 7 T W 71 T 7 - Z W.; ., . 7. , II. THE CARF GENERA7ION SYSTEM TODAY The previous and current CARF

  5. Assessing Legal Environment Factors that Impact in the Decision to Invest in Electricity generation from Renewable Resources – Case of Albania

    Directory of Open Access Journals (Sweden)

    ABAZ ALIKO

    2016-12-01

    Full Text Available Identifying and assessing the factors impacting investments in electricity generation is important for both private and public decision-makers. Understanding the decision-making process helps to stimulate and increase investments in the energy sector. This paper examines the legal environment factors that affect the decision to invest in electricity generation. Seventeen sub-factors of this environment are identified and its relative importance in the decision-making is measured, by interviewing 68 investors having invested or having obtained the right to invest in the electricity generation. We perform the Principal Component Analysis (PCA in 17 sub-factors to find more general latent structures (factors that characterize the legal environment affecting investments. The latent factors discovered are: Legal and Favourable Framework for the Concessions, Protecting Foreign Investments, Government Conditions and Bureaucracy as well as the Cascade Investments and Information. These are the most important factors of the legal environment in the decision-making process to invest in electricity generation.

  6. Factors affecting the appreciation generated through applying human factors/ergonomics (HFE) principles to systems of work.

    Science.gov (United States)

    So, R H Y; Lam, S T

    2014-01-01

    This retrospective study examined the levels of appreciation (applause) given by clients to Human Factors/Ergonomic (HFE) specialists after they have modified the systems of work. Thirteen non-academic projects were chosen because the HFE interventions involved changed the way workers work at their workplaces. Companies involved range from multi-national corporations and military organizations with thousands of employees to small trading companies with less than 10 employees. In 5 cases the HFE recommendations were fully adopted and well appreciated. In 4 they were largely ignored and not appreciated, with partial adoption and some appreciation in the other 4 cases. Three factors that predict appreciation were identified: (i) alignment between the benefits HFE can provide and the project's key performance indices; (ii) awareness of HFE among the client's senior management; and (iii) a team organization appropriate for applying HFE recommendations. Having an HFE specialist on the client's side can greatly increase levels of appreciation, but lack of such a specialist will not affect levels of appreciation. A clear contractual requirement for HFE intervention does not promote appreciation significantly, but its absence can greatly reduce levels of appreciation. These relationships are discussed using the Kano's model of quality. Means to generate greater appreciation of the benefits of HFE are discussed.

  7. Application of next-generation sequencing for comparative transcriptome analysis

    OpenAIRE

    Shin, Heesun

    2010-01-01

    I have used novel whole transcriptome sequence data generated from massively parallel high-throughput next generation sequencing technologies, namely 454 pyrosequencing and Illumina sequencing, to perform comparative transcriptome analyses of C. elegans populations in specific biological conditions and developmental stages. Firstly, I have conducted transcriptome profiling of C. elegans in its first larval (L1) stage using data generated from the Roche 454 sequencing platform. I have used thi...

  8. Millennial dissonance: an analysis of the privacy generational gap

    OpenAIRE

    Sher, Matthew J.

    2012-01-01

    The young Millennial generation has adopted social media and internet technology to an unprecedented degree. But this generation’s extensive usage of online services leaves Millennials open to various privacy vulnerabilities that have emerged with the new technology. Older generations hold concern that Millennials are ignoring the value of privacy when disclosing their personal information in exchange for online connectivity. This paper investigates the generational privacy concern through di...

  9. Entropy Generation Analysis of Human Thermal Stress Responses

    OpenAIRE

    Boregowda, Satish C.; Choate, Robert E.; Rodney Handy

    2012-01-01

    The present study involves application of an open system entropy generation formulation to analyze human thermal stress responses. The time-series human thermal stress response data are obtained by conducting a simulation using a validated finite-element human thermal model (FEHTM). These simulated human thermal response data are used as an input to the entropy generation expression to obtain human entropy generation (HEG) values. The effects of variables such as air temperature, relative hum...

  10. Millennial dissonance: an analysis of the privacy generational gap

    OpenAIRE

    Sher, Matthew J.

    2012-01-01

    The young Millennial generation has adopted social media and internet technology to an unprecedented degree. But this generation’s extensive usage of online services leaves Millennials open to various privacy vulnerabilities that have emerged with the new technology. Older generations hold concern that Millennials are ignoring the value of privacy when disclosing their personal information in exchange for online connectivity. This paper investigates the generational privacy concern through di...

  11. Disruptive Event Biosphere Doser Conversion Factor Analysis

    Energy Technology Data Exchange (ETDEWEB)

    M. Wasiolek

    2000-12-28

    The purpose of this report was to document the process leading to, and the results of, development of radionuclide-, exposure scenario-, and ash thickness-specific Biosphere Dose Conversion Factors (BDCFs) for the postulated postclosure extrusive igneous event (volcanic eruption) at Yucca Mountain. BDCF calculations were done for seventeen radionuclides. The selection of radionuclides included those that may be significant dose contributors during the compliance period of up to 10,000 years, as well as radionuclides of importance for up to 1 million years postclosure. The approach documented in this report takes into account human exposure during three different phases at the time of, and after, volcanic eruption. Calculations of disruptive event BDCFs used the GENII-S computer code in a series of probabilistic realizations to propagate the uncertainties of input parameters into the output. The pathway analysis included consideration of different exposure pathway's contribution to the BDCFs. BDCFs for volcanic eruption, when combined with the concentration of radioactivity deposited by eruption on the soil surface, allow calculation of potential radiation doses to the receptor of interest. Calculation of radioactivity deposition is outside the scope of this report and so is the transport of contaminated ash from the volcano to the location of the receptor. The integration of the biosphere modeling results (BDCFs) with the outcomes of the other component models is accomplished in the Total System Performance Assessment (TSPA), in which doses are calculated to the receptor of interest from radionuclides postulated to be released to the environment from the potential repository at Yucca Mountain.

  12. Nominal Performance Biosphere Dose Conversion Factor Analysis

    Energy Technology Data Exchange (ETDEWEB)

    M. Wasiolek

    2000-12-21

    The purpose of this report was to document the process leading to development of the Biosphere Dose Conversion Factors (BDCFs) for the postclosure nominal performance of the potential repository at Yucca Mountain. BDCF calculations concerned twenty-four radionuclides. This selection included sixteen radionuclides that may be significant nominal performance dose contributors during the compliance period of up to 10,000 years, five additional radionuclides of importance for up to 1 million years postclosure, and three relatively short-lived radionuclides important for the human intrusion scenario. Consideration of radionuclide buildup in soil caused by previous irrigation with contaminated groundwater was taken into account in the BDCF development. The effect of climate evolution, from the current arid conditions to a wetter and cooler climate, on the BDCF values was evaluated. The analysis included consideration of different exposure pathway's contribution to the BDCFs. Calculations of nominal performance BDCFs used the GENII-S computer code in a series of probabilistic realizations to propagate the uncertainties of input parameters into the output. BDCFs for the nominal performance, when combined with the concentrations of radionuclides in groundwater allow calculation of potential radiation doses to the receptor of interest. Calculated estimates of radionuclide concentration in groundwater result from the saturated zone modeling. The integration of the biosphere modeling results (BDCFs) with the outcomes of the other component models is accomplished in the Total System Performance Assessment (TSPA) to calculate doses to the receptor of interest from radionuclides postulated to be released to the environment from the potential repository at Yucca Mountain.

  13. Applied risk analysis to the future Brazilian electricity generation matrix

    Energy Technology Data Exchange (ETDEWEB)

    Maues, Jair; Fernandez, Eloi; Correa, Antonio

    2010-09-15

    This study compares energy conversion systems for the generation of electrical power, with an emphasis on the Brazilian energy matrix. The financial model applied in this comparison is based on the Portfolio Theory, developed by Harry Markowitz. The risk-return ratio related to the electrical generation mix predicted in the National Energy Plan - 2030, published in 2006 by the Brazilian Energy Research Office, is evaluated. The increase of non-traditional renewable energy in this expected electrical generating mix, specifically, residues of sugar cane plantations and wind energy, reduce not only the risk but also the average cost of the kilowatt-hour generated.

  14. Exploratory factor analysis and reliability analysis with missing data: A simple method for SPSS users

    Directory of Open Access Journals (Sweden)

    Bruce Weaver

    2014-09-01

    Full Text Available Missing data is a frequent problem for researchers conducting exploratory factor analysis (EFA or reliability analysis. The SPSS FACTOR procedure allows users to select listwise deletion, pairwise deletion or mean substitution as a method for dealing with missing data. The shortcomings of these methods are well-known. Graham (2009 argues that a much better way to deal with missing data in this context is to use a matrix of expectation maximization (EM covariances(or correlations as input for the analysis. SPSS users who have the Missing Values Analysis add-on module can obtain vectors ofEM means and standard deviations plus EM correlation and covariance matrices via the MVA procedure. But unfortunately, MVA has no /MATRIX subcommand, and therefore cannot write the EM correlations directly to a matrix dataset of the type needed as input to the FACTOR and RELIABILITY procedures. We describe two macros that (in conjunction with an intervening MVA command carry out the data management steps needed to create two matrix datasets, one containing EM correlations and the other EM covariances. Either of those matrix datasets can then be used asinput to the FACTOR procedure, and the EM correlations can also be used as input to RELIABILITY. We provide an example that illustrates the use of the two macros to generate the matrix datasets and how to use those datasets as input to the FACTOR and RELIABILITY procedures. We hope that this simple method for handling missing data will prove useful to both students andresearchers who are conducting EFA or reliability analysis.

  15. EXPLORATORY FACTOR ANALYSIS (EFA IN CONSUMER BEHAVIOR AND MARKETING RESEARCH

    Directory of Open Access Journals (Sweden)

    Marcos Pascual Soler

    2012-06-01

    Full Text Available Exploratory Factor Analysis (EFA is one of the most widely used statistical procedures in social research. The main objective of this work is to describe the most common practices used by researchers in the consumer behavior and marketing area. Through a literature review methodology the practices of AFE in five consumer behavior and marketing journals(2000-2010 were analyzed. Then, the choices made by the researchers concerning factor model, retention criteria, rotation, factors interpretation and other relevant issues to factor analysis were analized. The results suggest that researchers routinely conduct analyses using such questionable methods. Suggestions for improving the use of factor analysis and the reporting of results are presented and a checklist (Exploratory Factor Analysis Checklist, EFAC is provided to help editors, reviewers, and authors improve reporting exploratory factor analysis.

  16. Factor analysis of serogroups botanica and aurisina of Leptospira biflexa.

    Science.gov (United States)

    Cinco, M

    1977-11-01

    Factor analysis is performed on serovars of Botanica and Aurisina serogroup of Leptospira biflexa. The results show the arrangement of main factors serovar and serogroup specific, as well as the antigens common with serovars of heterologous serogroups.

  17. An Item Factor Analysis of the Mooney Problem Check List

    Science.gov (United States)

    Stewart, David W.; Deiker, Thomas

    1976-01-01

    Explores the factor structure of the Mooney Problem Check List (MPCL) at the junior and senior high school level by undertaking a large obverse factor analysis of item responses in three adolescent criterion groups. (Author/DEP)

  18. Full Information Item Factor Analysis of the FCI

    Science.gov (United States)

    Hagedorn, Eric

    2010-02-01

    Traditional factor analytical methods, principal factors or principal components analysis, are inappropriate techniques for analyzing dichotomously scored responses to standardized tests or concept inventories because they lead to artifactual factors often referred to as ``difficulty factors.'' Full information item factor analysis (Bock, Gibbons and Muraki, 1988) based on Thurstone's multiple factor model and calculated using marginal maximum likelihood estimation, is an appropriate technique for such analyses. Force Concept Inventory (Hestenes, Wells and Swackhamer, 1992) data from 1582 university students completing an introductory physics course, was analyzed using the full information item factor analysis software TESTFACT v. 4. Analyzing the statistical significance of successive factors added to the model, using chi-squared statistics, led to a six factor model interpretable in terms of the conceptual dimensions of the FCI. )

  19. An Analysis of Generational Differences Among Active Duty Members

    Science.gov (United States)

    2004-03-01

    studied differences between Baby Boomers (born 1946 – 1964), Generation Xers (born 1965 – 1977), and Millenials (born 1978 – 1995). They found that work ...that different generations have different attitudes toward work , organizations, and co-workers. Clearly, these observed differences have...characteristics and tested using a questionnaire that includes 77 items to assess general work attitudes, attitudes towards job and organization

  20. Performance analysis of voltage regulation in diesel-wind generation

    African Journals Online (AJOL)

    user

    wind stream in the spin of the turbine the spin is the mechanical energy, now this mechanical energy is ... magnet synchronous generator is also their according to the electrical power generation these ..... Rotor flux component in q axis φdr.

  1. Windfarm generation assessment for reliability analysis of power systems

    DEFF Research Database (Denmark)

    Negra, N.B.; Holmstrøm, O.; Bak-Jensen, B.;

    2007-01-01

    Due to the fast development of wind generation in the past ten years, increasing interest has been paid to techniques for assessing different aspects of power systems with a large amount of installed wind generation. One of these aspects concerns power system reliability. Windfarm modelling plays...

  2. Time series power flow analysis for distribution connected PV generation.

    Energy Technology Data Exchange (ETDEWEB)

    Broderick, Robert Joseph; Quiroz, Jimmy Edward; Ellis, Abraham; Reno, Matthew J.; Smith, Jeff; Dugan, Roger

    2013-01-01

    Distributed photovoltaic (PV) projects must go through an interconnection study process before connecting to the distribution grid. These studies are intended to identify the likely impacts and mitigation alternatives. In the majority of the cases, system impacts can be ruled out or mitigation can be identified without an involved study, through a screening process or a simple supplemental review study. For some proposed projects, expensive and time-consuming interconnection studies are required. The challenges to performing the studies are twofold. First, every study scenario is potentially unique, as the studies are often highly specific to the amount of PV generation capacity that varies greatly from feeder to feeder and is often unevenly distributed along the same feeder. This can cause location-specific impacts and mitigations. The second challenge is the inherent variability in PV power output which can interact with feeder operation in complex ways, by affecting the operation of voltage regulation and protection devices. The typical simulation tools and methods in use today for distribution system planning are often not adequate to accurately assess these potential impacts. This report demonstrates how quasi-static time series (QSTS) simulation and high time-resolution data can be used to assess the potential impacts in a more comprehensive manner. The QSTS simulations are applied to a set of sample feeders with high PV deployment to illustrate the usefulness of the approach. The report describes methods that can help determine how PV affects distribution system operations. The simulation results are focused on enhancing the understanding of the underlying technical issues. The examples also highlight the steps needed to perform QSTS simulation and describe the data needed to drive the simulations. The goal of this report is to make the methodology of time series power flow analysis readily accessible to utilities and others responsible for evaluating

  3. Analysis of subsurface storage and streamflow generation in urban watersheds

    Science.gov (United States)

    Bhaskar, Aditi S.; Welty, Claire

    2015-03-01

    Subsurface storage as a regulator of streamflow was investigated as an explanation for the large proportion of pre-event water observed in urban streams during storm events. We used multiple lines of inquiry to explore the relationship between pre-event water proportion, subsurface storage, and streamflow under storm conditions. First, we used a three-dimensional model of integrated subsurface and surface flow and solute transport to simulate an idealized hillslope to perform model-based chemical hydrograph separation of stormflow. Second, we employed simple dynamical systems analysis to derive the relationship between subsurface storage and streamflow for three Baltimore, Maryland watersheds (3.8-14 km2 in area) along an urban-to-rural gradient. Last, we applied chemical hydrograph separation to high-frequency specific conductance data in nested urban watersheds (˜50% impervious surface cover) in Dead Run, Baltimore County, Maryland. Unlike the importance of antecedent subsurface storage observed in some systems, we found that rainfall depth and not subsurface storage was the primary control on pre-event water proportion in both field observations and hillslope numerical experiments. Field observations showed that antecedent stream base flow did not affect pre-event water proportion or streamflow values under storm conditions. Hillslope model results showed that the relationship between streamflow values under storm conditions and subsurface storage was clockwise hysteretic. The simple dynamical systems approach showed that stream base flow in the most urbanized of three watersheds exhibited the largest sensitivity to changes in storage. This work raises questions about the streamflow generation mechanisms by which pre-event water dominates urban storm hydrographs, and the shifts between mechanisms in rural and urban watersheds.

  4. Exploratory matrix factorization for PET image analysis.

    Science.gov (United States)

    Kodewitz, A; Keck, I R; Tomé, A M; Lang, E W

    2010-01-01

    Features are extracted from PET images employing exploratory matrix factorization techniques such as nonnegative matrix factorization (NMF). Appropriate features are fed into classifiers such as a support vector machine or a random forest tree classifier. An automatic feature extraction and classification is achieved with high classification rate which is robust and reliable and can help in an early diagnosis of Alzheimer's disease.

  5. Exploring Technostress: Results of a Large Sample Factor Analysis

    OpenAIRE

    Steponas Jonušauskas; Agota Giedre Raisiene

    2016-01-01

    With reference to the results of a large sample factor analysis, the article aims to propose the frame examining technostress in a population. The survey and principal component analysis of the sample consisting of 1013 individuals who use ICT in their everyday work was implemented in the research. 13 factors combine 68 questions and explain 59.13 per cent of the answers dispersion. Based on the factor analysis, questionnaire was reframed and prepared to reasonably analyze the respondents’ an...

  6. Environmental justice implications of industrial hazardous waste generation in India: a national scale analysis

    Science.gov (United States)

    Basu, Pratyusha; Chakraborty, Jayajit

    2016-12-01

    While rising air and water pollution have become issues of widespread public concern in India, the relationship between spatial distribution of environmental pollution and social disadvantage has received less attention. This lack of attention becomes particularly relevant in the context of industrial pollution, as India continues to pursue industrial development policies without sufficient regard to its adverse social impacts. This letter examines industrial pollution in India from an environmental justice (EJ) perspective by presenting a national scale study of social inequities in the distribution of industrial hazardous waste generation. Our analysis connects district-level data from the 2009 National Inventory of Hazardous Waste Generating Industries with variables representing urbanization, social disadvantage, and socioeconomic status from the 2011 Census of India. Our results indicate that more urbanized and densely populated districts with a higher proportion of socially and economically disadvantaged residents are significantly more likely to generate hazardous waste. The quantity of hazardous waste generated is significantly higher in more urbanized but sparsely populated districts with a higher proportion of economically disadvantaged households, after accounting for other relevant explanatory factors such as literacy and social disadvantage. These findings underscore the growing need to incorporate EJ considerations in future industrial development and waste management in India.

  7. Effect Factors of Liquid Scintillation Analysis

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>Over the past decades, the liquid scintillation analysis (LSA) technique remains one of the most popular experimental tools used for the quantitative analysis of radionuclide, especially low-energy β

  8. Effect of graph generation on slope stability analysis based on graph theory

    Institute of Scientific and Technical Information of China (English)

    Enpu Li; Xiaoying Zhuang; Wenbo Zheng; Yongchang Cai

    2014-01-01

    Limit equilibrium method (LEM) and strength reduction method (SRM) are the most widely used methods for slope stability analysis. However, it can be noted that they both have some limitations in practical application. In the LEM, the constitutive model cannot be considered and many assumptions are needed between slices of soil/rock. The SRM requires iterative calculations and does not give the slip surface directly. A method for slope stability analysis based on the graph theory is recently developed to directly calculate the minimum safety factor and potential critical slip surface according to the stress results of numerical simulation. The method is based on current stress state and can overcome the disadvantages mentioned above in the two traditional methods. The influences of edge generation and mesh geometry on the position of slip surface and the safety factor of slope are studied, in which a new method for edge generation is proposed, and reasonable mesh size is suggested. The results of bench-mark examples and a rock slope show good accuracy and efficiency of the presented method.

  9. Generating induced pluripotent stem cells from common marmoset (Callithrix jacchus) fetal liver cells using defined factors, including Lin28.

    Science.gov (United States)

    Tomioka, Ikuo; Maeda, Takuji; Shimada, Hiroko; Kawai, Kenji; Okada, Yohei; Igarashi, Hiroshi; Oiwa, Ryo; Iwasaki, Tsuyoshi; Aoki, Mikio; Kimura, Toru; Shiozawa, Seiji; Shinohara, Haruka; Suemizu, Hiroshi; Sasaki, Erika; Okano, Hideyuki

    2010-09-01

    Although embryonic stem (ES) cell-like induced pluripotent stem (iPS) cells have potential therapeutic applications in humans, they are also useful for creating genetically modified human disease models in nonhuman primates. In this study, we generated common marmoset iPS cells from fetal liver cells via the retrovirus-mediated introduction of six human transcription factors: Oct-3/4, Sox2, Klf4, c-Myc, Nanog, and Lin28. Four to five weeks after introduction, several colonies resembling marmoset ES cells were observed and picked for further expansion in ES cell medium. Eight cell lines were established, and validation analyses of the marmoset iPS cells followed. We detected the expression of ES cell-specific surface markers. Reverse transcription-PCR showed that these iPS cells expressed endogenous Oct-3/4, Sox2, Klf4, c-Myc, Nanog and Lin28 genes, whereas all of the transgenes were silenced. Karyotype analysis showed that two of three iPS cell lines retained a normal karyotype after a 2-month culture. Both embryoid body and teratoma formation showed that marmoset iPS cells had the developmental potential to give rise to differentiated derivatives of all three primary germ layers. In summary, we generated marmoset iPS cells via the transduction of six transcription factors; this provides a powerful preclinical model for studies in regenerative medicine.

  10. Enhancing factors of electricity generation in a microbial fuel cell using Geobacter sulfurreducens.

    Science.gov (United States)

    Kim, Mi-Sun; Cha, Jaehwan; Kim, Dong-Hoon

    2012-10-01

    In this study, we investigated various cultural and operational factors to enhance electricity generation in a microbial fuel cell (MFC) using Geobacter sulfurreducens. The pure culture of G. sulfurreducens was cultivated using various substrates including acetate, malate, succinate, and butyrate, with fumarate as an electron acceptor. Cell growth was observed only in acetate-fed medium, when the cell concentrations increased 4-fold for 3 days. A high acetate concentration suppressed electricity generation. As the acetate concentration was increased from 5 to 20 mM, the power density dropped from 16 to 13 mW/m2, whereas the coulombic efficiency (CE) declined by about half. The immobilization of G. sulfurreducens on the anode considerably reduced the enrichment period from 15 to 7 days. Using argon gas to create an anaerobic condition in the anode chamber led to increased pH, and electricity generation subsequently dropped. When the plain carbon paper cathode was replaced by Pt-coated carbon paper (0.5 mg Pt/cm2), the CE increased greatly from 39% to 83%.

  11. Analysis of reactive oxygen species generating systems in rat epididymal spermatozoa.

    Science.gov (United States)

    Vernet, P; Fulton, N; Wallace, C; Aitken, R J

    2001-10-01

    Epididymal sperm maturation culminates in the acquisition of functional competence by testicular spermatozoa. The expression of this functional state is dependent upon a redox-regulated, cAMP-mediated signal transduction cascade that controls the tyrosine phosphorylation status of the spermatozoa during capacitation. Analysis of superoxide anion (O2(-.)) generation by rat epididymal spermatozoa has revealed a two-component process involving electron leakage from the sperm mitochondria at complexes I and II and a plasma membrane NAD(P)H oxidoreductase. Following incubation in a glucose-, lactate-, and pyruvate-free medium (-GLP), O2(-.) generation was suppressed by 86% and 96% in caput and cauda spermatozoa, respectively. The addition of lactate, malate, or succinate to spermatozoa incubated in medium -GLP stimulated O2(-.) generation. This increase could be blocked by rotenone and oligomycin (R/O) in the presence of malate or lactate but not succinate. Stimulation with all three substrates, as well as spontaneous O2(-.) production in +GLP medium, was blocked by the flavoprotein inhibitor, diphenylene iodonium. Diphenylene iodonium, but not R/O, suppressed NAD(P)H-induced lucigenin-dependent chemiluminescence. This NAD(P)H-dependent enzyme resided in the sperm plasma membrane and its activity was regulated by zinc and uncharacterized cytosolic factors. Reverse transcription-polymerase chain reaction analysis indicated that the sperm NAD(P)H oxidoreductase complex is quite distinct from the equivalent leukocyte system.

  12. Confirmatory factor analysis of teaching and learning guiding principles instrument among teacher educators in higher education institutions

    Science.gov (United States)

    Masuwai, Azwani; Tajudin, Nor'ain Mohd; Saad, Noor Shah

    2017-05-01

    The purpose of this study is to develop and establish the validity and reliability of an instrument to generate teaching and learning guiding principles using Teaching and Learning Guiding Principles Instrument (TLGPI). Participants consisted of 171 Malaysian teacher educators. It is an essential instrument to reflect in generating the teaching and learning guiding principles in higher education level in Malaysia. Confirmatory Factor Analysis has validated all 19 items of TLGPI whereby all items indicated high reliability and internal consistency. A Confirmatory Factor Analysis also confirmed that a single factor model was used to generate teaching and learning guiding principles.

  13. Generation of induced pluripotent stem cells from buffalo (Bubalus bubalis) fetal fibroblasts with buffalo defined factors.

    Science.gov (United States)

    Deng, Yanfei; Liu, Qingyou; Luo, Chan; Chen, Shibei; Li, Xiangping; Wang, Caizhu; Liu, Zhenzhen; Lei, Xiaocan; Zhang, Huina; Sun, Hongliang; Lu, Fenghua; Jiang, Jianrong; Shi, Deshun

    2012-09-01

    Ectopically, expression of defined factors could reprogram mammalian somatic cells into induced pluripotent stem cells (iPSCs), which initiates a new strategy to obtain pluripotent stem cell lines. Attempts have been made to generate buffalo pluripotent stem cells by culturing primary germ cells or inner cell mass, but the efficiency is extremely low. Here, we report a successful method to reprogram buffalo fetal fibroblasts (BFFs) into pluripotent stem cells [buffalo induced pluripotent stem cell (biPSCs)] by transduction of buffalo defined factors (Oct4, Sox2, Klf4, and c-Myc) using retroviral vectors. The established biPSCs displayed typical morphological characteristics of pluripotent stem cells, normal karyotype, positive staining of alkaline phosphatase, and expressed pluripotent markers including Oct4, Sox2, Nanog, Lin28, E-Cadherin, SSEA-1, SSEA-4, TRA-1-81, STAT3, and FOXD3. They could form embryoid bodies (EBs) in vitro and teratomas after injecting into the nude BALB/C mice, and 3 germ layers were identified in the EBs and teratomas. Methylation assay revealed that the promoters of Oct4 and Nanog were hypomethylated in biPSCs compared with BFFs and pre-biPSCs, while the promoters of Sox2 and E-Cadherin were hypomethylated in both BFFs and biPSCs. Further, inhibiting p53 expression by coexpression of SV40 large T antigen and buffalo defined factors in BFFs or treating BFFs with p53 inhibitor pifithrin-a (PFT) could increase the efficiency of biPSCs generation up to 3-fold, and nuclear transfer embryos reconstructed with biPSCs could develop to blastocysts. These results indicate that BFFs can be reprogrammed into biPSCs by buffalo defined factors, and the generation efficiency of biPSCs can be increased by inhibition of p53 expression. These efforts will provide a feasible approach for investigating buffalo stem cell signal pathways, establishing buffalo stem cell lines, and producing genetic modification buffaloes in the future.

  14. Design and analysis of permanent magnet moving coil type generator used in a micro-CHP generation system

    Science.gov (United States)

    Oros Pop, Susana Teodora; Berinde, Ioan; Vadan, Ioan

    2015-12-01

    This paper presents the design and analysis of a permanent magnet moving coil type generator driven by a free piston Stirling engine. This assemble free piston Stirling engine - permanent magnet moving coil type generator will be used in a combined heat and power (CHP) system for producing heat and power in residential area. The design procedure for moving coil type linear generator starts from the rated power imposed and finally uses the Faraday law of induction. The magneto-static magnetic field generated by permanent magnets is analyzed by means of Reluctance method and Finite Element Method in order to evaluate the magnetic flux density in the air gap, which is a design data imposed in the design stage, and the results are compared.

  15. Design of sustainable chemical processes: Systematic retrofit analysis, generation and evaluation alternatives

    DEFF Research Database (Denmark)

    Carvalho, Ana; Gani, Rafiqul; Matos, Henrique

    2008-01-01

    The objective of this paper is to present a generic and systematic methodology for identifying the feasible retrofit design alternatives of any chemical process. The methodology determines a set of mass and energy indicators from steady-state process data, establishes the operational and design...... targets, and through a sensitivity-based analysis, identifies the design alternatives that can match a set of design targets. The significance of this indicator-based method is that it is able to identify alternatives, where one or more performance criteria (factors) move in the same direction thereby...... eliminating the need to identify trade-off-based solutions. These indicators are also able to reduce (where feasible) a set of safety indicators. An indicator sensitivity analysis algorithm has been added to the methodology to define design targets and to generate sustainable process alternatives. A computer...

  16. Combing Ability Analysis ofamong Early Generation Maize Inbred ...

    African Journals Online (AJOL)

    dagne.cimdom

    Combining ability estimates are important genetic attributes ina maize breeding ... Twenty-nine early generation maize inbred lines were crossed to two ...... agronomic traits in quality protein maize under stress and non stress environments.

  17. Generation and Analysis of Constrained Random Sampling Patterns

    DEFF Research Database (Denmark)

    Pierzchlewski, Jacek; Arildsen, Thomas

    2016-01-01

    indicates signal sampling points in time. Practical random sampling patterns are constrained by ADC characteristics and application requirements. In this paper, we introduce statistical methods which evaluate random sampling pattern generators with emphasis on practical applications. Furthermore, we propose...... a new random pattern generator which copes with strict practical limitations imposed on patterns, with possibly minimal loss in randomness of sampling. The proposed generator is compared with existing sampling pattern generators using the introduced statistical methods. It is shown that the proposed......Random sampling is a technique for signal acquisition which is gaining popularity in practical signal processing systems. Nowadays, event-driven analog-to-digital converters make random sampling feasible in practical applications. A process of random sampling is defined by a sampling pattern, which...

  18. Factors Influencing the Use of Second-Generation Antipsychotics in Children with Psychosis.

    Science.gov (United States)

    Ramachandran, Sujith; Banahan, Benjamin F; Bentley, John P; West-Strum, Donna S; Patel, Amit S

    2016-08-01

    In 2011, the U.S. Department of Health and Human Services sent a letter to state Medicaid directors explaining the need for oversight of psychiatric prescriptions for children with mental health disorders. The National Committee for Quality Alliance proposed 3 quality measures for rating managed care organizations (MCOs) that involve use of second-generation or atypical antipsychotics in children. In order to ensure appropriate use and to effectively manage the use of second-generation antipsychotics in children, MCOs need to better understand the factors that influence medication treatment decisions for children. To (a) determine how patient-level and physician-level factors influence decisions to prescribe second-generation antipsychotics to children (aged under 18 years) diagnosed with psychosis and (b) evaluate how the influence of these factors may differ between primary care providers and psychiatrists. This study employed a cross-sectional survey of 193 primary care providers and psychiatrists. A web-based patient simulation survey using a fractional factorial design was administered via a commercial vendor. Respondents were presented with simulated patient profiles described by various levels of factors considered to be essential to decision making. Respondents were asked to make treatment recommendations for each profile evaluated. In addition to treatment recommendations, demographics and beliefs about products were measured. Modified Poisson regression accounting for multilevel data was used to identify the factors that significantly affect treatment recommendations. Psychiatrists were more likely to recommend second-generation antipsychotics than primary care practitioners (unadjusted RR = 1.36, 95% CI = 1.23-1.51). Social factors such as foster status or parental concern were not found to be significant predictors of prescribing second-generation antipsychotics. The percentage of a provider's patients using second-generation antipsychotics (RR = 1

  19. Towards an Explanation Generation System for Robots: Analysis and Recommendations

    Directory of Open Access Journals (Sweden)

    Ben Meadows

    2016-10-01

    Full Text Available A fundamental challenge in robotics is to reason with incomplete domain knowledge to explain unexpected observations and partial descriptions extracted from sensor observations. Existing explanation generation systems draw on ideas that can be mapped to a multidimensional space of system characteristics, defined by distinctions, such as how they represent knowledge and if and how they reason with heuristic guidance. Instances in this multidimensional space corresponding to existing systems do not support all of the desired explanation generation capabilities for robots. We seek to address this limitation by thoroughly understanding the range of explanation generation capabilities and the interplay between the distinctions that characterize them. Towards this objective, this paper first specifies three fundamental distinctions that can be used to characterize many existing explanation generation systems. We explore and understand the effects of these distinctions by comparing the capabilities of two systems that differ substantially along these axes, using execution scenarios involving a robot waiter assisting in seating people and delivering orders in a restaurant. The second part of the paper uses this study to argue that the desired explanation generation capabilities corresponding to these three distinctions can mostly be achieved by exploiting the complementary strengths of the two systems that were explored. This is followed by a discussion of the capabilities related to other major distinctions to provide detailed recommendations for developing an explanation generation system for robots.

  20. Generation and characterization of monoclonal antibodies against the transcription factor Nkx6.1.

    Science.gov (United States)

    Pedersen, Inger L; Klinck, Rasmus; Hecksher-Sorensen, Jacob; Zahn, Stefan; Madsen, Ole D; Serup, Palle; Jorgensen, Mette C

    2006-05-01

    We present the generation of a panel of monoclonal antibodies (F55A10, F55A12, F64A6B4, and F65A2) against the homeodomain transcription factor Nkx6.1, one of the essential transcription factors that regulates the multistep differentiation process of precursor cells into endocrine beta-cells in the pancreas. Expression of Nkx6.1 can be detected in developing pancreatic epithelium and in adult insulin-producing beta-cells, making this transcription factor a unique beta-cell marker. For production of monoclonal antibodies, RBF mice were immunized with a GST-Nkx6.1 fusion protein containing a 66-amino acid C-terminal fragment of rat Nkx6.1. Four clones were established as stable hybridoma cell lines and the produced antibodies were of the mouse IgG1/kappa subtype. When applied for immunohistochemistry on frozen sections of adult mouse pancreas, monoclonal antibodies stain specifically the beta-cells in the endocrine islets of Langerhans with patterns comparable to that of a previously produced polyclonal rabbit serum. Monoclonal antibodies can be divided into two groups that appear to recognize different epitopes, as determined by competition ELISA. The presented antibodies are useful tools for the further characterization of the role and function of Nkx6.1 in pancreatic development, especially for use in double-labeling experiments with existing polyclonal rabbit antibodies.

  1. Single cell transcriptome analysis using next generation sequencing.

    OpenAIRE

    Blattner, M.

    2010-01-01

    The heterogeneity of tissues, especially in cancer research, is a central issue in transcriptome analysis. In recent years, research has primarily focused on the development of methods for single cell analysis. Single cell analysis aims at gaining (novel) insights into biological processes of healthy and diseased cells. Some of the challenges in transcriptome analysis concern low abundance of sample starting material, necessary sample amplification steps and subsequent analysis. In this study...

  2. Sensitivity Factor Analysis For Unit Commitment In Loaded Lines

    Directory of Open Access Journals (Sweden)

    Lata Chaudhary

    2016-05-01

    Full Text Available In today’s competitive electricity market, it is not possible to settle all contracted transactions of power because of congestion in transmission lines. Usually, the independent system operator seeks to eliminate congestion by rescheduling output power of the generators. But all generators may not have the same effect (sensitivity on the power flow of the congested lines, so this is not an economical way to reschedule output power of all generators for managing congestion. Therefore, in this paper, active power generator sensitivity factor of the generators to the congested lines have been utilized to ascertain the number of generators participating in congestion management. The effectiveness and feasibility of the proposed algorithm have been tested on IEEE 30 bus system

  3. Attitude Exploration Using Factor Analysis Technique

    OpenAIRE

    2016-01-01

    Attitude is a psychological variable that contains positive or negative evaluation about people or an environment. The growing generation possesses learning skills, so if positive attitude is inculcated at the right age, it might therefore become habitual. Students in the age group 14-20 years from the city of Bikaner, India, are the target population for this study. An inventory of 30Likert-type scale statements was prepared in order to measure attitude towards the environment and matters re...

  4. FACTOR ANALYSIS OF THE ELKINS HYPNOTIZABILITY SCALE

    Science.gov (United States)

    Elkins, Gary; Johnson, Aimee K.; Johnson, Alisa J.; Sliwinski, Jim

    2015-01-01

    Assessment of hypnotizability can provide important information for hypnosis research and practice. The Elkins Hypnotizability Scale (EHS) consists of 12 items and was developed to provide a time-efficient measure for use in both clinical and laboratory settings. The EHS has been shown to be a reliable measure with support for convergent validity with the Stanford Hypnotic Susceptibility Scale, Form C (r = .821, p < .001). The current study examined the factor structure of the EHS, which was administered to 252 adults (51.3% male; 48.7% female). Average time of administration was 25.8 minutes. Four factors selected on the basis of the best theoretical fit accounted for 63.37% of the variance. The results of this study provide an initial factor structure for the EHS. PMID:25978085

  5. ANALYSIS OF EXTERNAL FACTORS AFFECTING THE PRICING

    Directory of Open Access Journals (Sweden)

    Irina A. Kiseleva

    2013-01-01

    Full Text Available The external factors influencing the process of formation of tariffs of commercial services are considered in the article. External environment is known to be very diverse and changeable. Currently, pricing has become one of the key processes of strategic development of a company. Pricing in the service sector, in turn, is highly susceptible to changes in the external environment. Its components directly or indirectly affect the market of services, changing it adopted economic processes. As a rule, firms providing services can’t influence the changes in external factors. However, the service market is very flexible, which enables businesses to reshape pricing strategy, to adapt it to the new environment.

  6. International Normalized Ratio (INR), coagulation factor activities and calibrated automated thrombin generation - influence of 24 h storage at ambient temperature

    DEFF Research Database (Denmark)

    Christensen, T D; Jensen, C; Larsen, T B

    2010-01-01

    International Normalized Ratio (INR) measurements are used to monitor oral anticoagulation therapy with coumarins. Single coagulation factor activities and calibrated automated thrombin (CAT) generation are considered as more advanced methods for evaluating overall haemostatic capacity. The aims...

  7. Next-Generation Sequencing of Genomic DNA Fragments Bound to a Transcription Factor in Vitro Reveals Its Regulatory Potential

    Directory of Open Access Journals (Sweden)

    Yukio Kurihara

    2014-12-01

    Full Text Available Several transcription factors (TFs coordinate to regulate expression of specific genes at the transcriptional level. In Arabidopsis thaliana it is estimated that approximately 10% of all genes encode TFs or TF-like proteins. It is important to identify target genes that are directly regulated by TFs in order to understand the complete picture of a plant’s transcriptome profile. Here, we investigate the role of the LONG HYPOCOTYL5 (HY5 transcription factor that acts as a regulator of photomorphogenesis. We used an in vitro genomic DNA binding assay coupled with immunoprecipitation and next-generation sequencing (gDB-seq instead of the in vivo chromatin immunoprecipitation (ChIP-based methods. The results demonstrate that the HY5-binding motif predicted here was similar to the motif reported previously and that in vitro HY5-binding loci largely overlapped with the HY5-targeted candidate genes identified in previous ChIP-chip analysis. By combining these results with microarray analysis, we identified hundreds of HY5-binding genes that were differentially expressed in hy5. We also observed delayed induction of some transcripts of HY5-binding genes in hy5 mutants in response to blue-light exposure after dark treatment. Thus, an in vitro gDNA-binding assay coupled with sequencing is a convenient and powerful method to bridge the gap between identifying TF binding potential and establishing function.

  8. Entropy generation analysis of cylindrical heat pipe using nanofluid

    Energy Technology Data Exchange (ETDEWEB)

    Ghanbarpour, Morteza, E-mail: morteza.ghanbarpour@energy.kth.se; Khodabandeh, Rahmatollah

    2015-06-20

    Highlights: • Entropy generation of heat pipe with nanofluid has been studied. • Nanofluid has significant effect on heat pipe performance. • Entropy generation in heat pipe decreases when nanofluids are used as working fluids. - Abstract: Thermal performance of cylindrical heat pipe with nanofluid is studied based on the laws of thermodynamics. The objective of the present work is to investigate nanofluids effect on different sources of entropy generation in heat pipe caused by heat transfer between hot and cold reservoirs and also frictional losses and pressure drop in the liquid and vapor flow along heat pipe. An analytical study was performed to formulate all sources of entropy generation and the predicted results are compared with experimental ones. Cylindrical miniature grooved heat pipes of 250 mm length and 6.35 mm outer diameter were fabricated and tested with distilled water and water based TiO{sub 2} and Al{sub 2}O{sub 3} nanofluids at different concentrations as working fluids. Analytical and experimental results revealed that the entropy generation in heat pipes decreases when nanofluids are used as working fluids instead of basefluid which results in improved thermal performance of the heat pipes with nanofluids.

  9. Factor Analysis for Spectral Reconnaissance and Situational Understanding

    Science.gov (United States)

    2016-07-11

    reviewed journals: Final Report: Factor Analysis for Spectral Reconnaissance and Situational Understanding Report Title The Army has a critical need for...based NP-hard design problems, by associating them with corresponding estimation problems. 1 Factor Analysis for Spectral Reconnaissance and Situational ...SECURITY CLASSIFICATION OF: The Army has a critical need for enhancing situational understanding for dismounted soldiers and rapidly deployed tactical

  10. A Factor Analysis of the BSRI and the PAQ.

    Science.gov (United States)

    Edwards, Teresa A.; And Others

    Factor analysis of the Bem Sex Role Inventory (BSRI) and the Personality Attributes Questionnaire (PAQ) was undertaken to study the independence of the masculine and feminine scales within each instrument. Both instruments were administered to undergraduate education majors. Analysis of primary first and second order factors of the BSRI indicated…

  11. Exploratory Factor Analysis of African Self-Consciousness Scale Scores

    Science.gov (United States)

    Bhagwat, Ranjit; Kelly, Shalonda; Lambert, Michael C.

    2012-01-01

    This study replicates and extends prior studies of the dimensionality, convergent, and external validity of African Self-Consciousness Scale scores with appropriate exploratory factor analysis methods and a large gender balanced sample (N = 348). Viable one- and two-factor solutions were cross-validated. Both first factors overlapped significantly…

  12. Multigroup Confirmatory Factor Analysis: Locating the Invariant Referent Sets

    Science.gov (United States)

    French, Brian F.; Finch, W. Holmes

    2008-01-01

    Multigroup confirmatory factor analysis (MCFA) is a popular method for the examination of measurement invariance and specifically, factor invariance. Recent research has begun to focus on using MCFA to detect invariance for test items. MCFA requires certain parameters (e.g., factor loadings) to be constrained for model identification, which are…

  13. Factor Analysis of People Rather than Variables: Q and Other Two-Mode Factor Analytic Models.

    Science.gov (United States)

    Frederick, Brigitte N.

    Factor analysis attempts to study how different objects group together to form factors with the purposes of: (1) reducing the number of factorable entities (e.g., variables) with which the researcher needs to deal; (2) searching data for qualitative and quantitative differences; and (3) testing hypotheses (R. Gorsuch, 1983). While most factor…

  14. Chiral analysis of baryon form factors

    Energy Technology Data Exchange (ETDEWEB)

    Gail, T.A.

    2007-11-08

    This work presents an extensive theoretical investigation of the structure of the nucleon within the standard model of elementary particle physics. In particular, the long range contributions to a number of various form factors parametrizing the interactions of the nucleon with an electromagnetic probe are calculated. The theoretical framework for those calculations is chiral perturbation theory, the exact low energy limit of Quantum Chromo Dynamics, which describes such long range contributions in terms of a pion-cloud. In this theory, a nonrelativistic leading one loop order calculation of the form factors parametrizing the vector transition of a nucleon to its lowest lying resonance, the {delta}, a covariant calculation of the isovector and isoscalar vector form factors of the nucleon at next to leading one loop order and a covariant calculation of the isoscalar and isovector generalized vector form factors of the nucleon at leading one loop order are performed. In order to perform consistent loop calculations in the covariant formulation of chiral perturbation theory an appropriate renormalization scheme is defined in this work. All theoretical predictions are compared to phenomenology and results from lattice QCD simulations. These comparisons allow for a determination of the low energy constants of the theory. Furthermore, the possibility of chiral extrapolation, i.e. the extrapolation of lattice data from simulations at large pion masses down to the small physical pion mass is studied in detail. Statistical as well as systematic uncertainties are estimated for all results throughout this work. (orig.)

  15. Analysis of circular wave packets generated by pulsed electric fields

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, S., E-mail: shuhei@concord.itp.tuwien.ac.at [Institute for Theoretical Physics, Vienna University of Technology, Vienna (Austria); Reinhold, C.O. [Physics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6372 (United States); Department of Physics, University of Tennessee, Knoxville, TN 37996 (United States); Burgdoerfer, J. [Institute for Theoretical Physics, Vienna University of Technology, Vienna (Austria); Department of Physics, University of Tennessee, Knoxville, TN 37996 (United States); Wyker, B.; Ye, S.; Dunning, F.B. [Department of Physics and Astronomy and the Rice Quantum Institute, Rice University, Houston, TX 77005-1892 (United States)

    2012-05-15

    We demonstrate that circular wave packets in high Rydberg states generated by a pulsed electric field applied to extreme Stark states are characterized by a position-dependent energy gradient that leads to a correlation between the principal quantum number n and the spatial coordinate. This correlation is rather insensitive to the initial state and can be seen even in an incoherent mix of states such as is generated experimentally allowing information to be placed into, and extracted from, such wave packets. We show that detailed information on the spatial distribution of a circular wave packet can be extracted by analyzing the complex phase of its expansion coefficients.

  16. Analysis of Circular Wave Packets Generated by Pulsed Electric Fields

    Energy Technology Data Exchange (ETDEWEB)

    Yoshida, S. [Vienna University of Technology, Austria; Reinhold, Carlos O [ORNL; Burgdorfer, J. [Vienna University of Technology, Austria; Wyker, B. [Rice University; Ye, S. [Rice University; Dunning, F. B. [Rice University

    2011-01-01

    We demonstrate that circular wave packets in high Rydberg states generated using a pulsed electric field applied to extreme Stark states are characterized by a position-dependent energy gradient that leads to a correlation between the principal quantum number n and the spatial coordinate. This correlation is rather insensitive to the initial state and can be seen even in an incoherent mix of states such as is generated experimentally allowing information to be placed into, and extracted from, such wavepackets. We show that detailed information on the spatial distribution of a circular wave packet can be extracted by analyzing the complex phase of its expansion coefficient.

  17. Image analysis techniques associated with automatic data base generation.

    Science.gov (United States)

    Bond, A. D.; Ramapriyan, H. K.; Atkinson, R. J.; Hodges, B. C.; Thomas, D. T.

    1973-01-01

    This paper considers some basic problems relating to automatic data base generation from imagery, the primary emphasis being on fast and efficient automatic extraction of relevant pictorial information. Among the techniques discussed are recursive implementations of some particular types of filters which are much faster than FFT implementations, a 'sequential similarity detection' technique of implementing matched filters, and sequential linear classification of multispectral imagery. Several applications of the above techniques are presented including enhancement of underwater, aerial and radiographic imagery, detection and reconstruction of particular types of features in images, automatic picture registration and classification of multiband aerial photographs to generate thematic land use maps.

  18. Analysis of solidification and melting of Pcm with energy generation

    Energy Technology Data Exchange (ETDEWEB)

    Jiji, Latif M. [Department of Mechanical Engineering, The City College of the City University of New York, New York, NY 10031 (United States); Gaye, Salif [Ecole Superieure Polytechnique, Enseignant a l' ESP BP A10, Universite Cheikh Anta Diop, Thies (Senegal)

    2006-04-01

    One-dimensional solidification and melting of a slab with uniform volumetric energy generation is examined analytically. A sudden change in surface temperature triggers phase transformation and interface motion. Analytic solutions are obtained using a quasi-steady approximation. Unlike solidification, the melting case is characterized by a pure liquid phase and a mixture of solid and liquid at the fusion temperature. The solution is governed by a single energy generation parameter. Temperature profiles, interface location and steady state conditions are presented for solidification and melting. Results are applied to two examples: solidification of a nuclear material and melting of ice. [Author].

  19. Explanatory factors for first and second-generation non-western women's inadequate prenatal care utilisation : a prospective cohort study

    NARCIS (Netherlands)

    Boerleider, Agatha W; Manniën, Judith; van Stenus, Cherelle M V; Wiegers, Therese A; Feijen-de Jong, Esther I; Spelten, Evelien R; Devillé, Walter L J M

    2015-01-01

    BACKGROUND: Little research into non-western women's prenatal care utilisation in industrialised western countries has taken generational differences into account. In this study we examined non-western women's prenatal care utilisation and its explanatory factors according to generational status.

  20. Social and cultural factors underlying generational differences in overweight: a cross-sectional study among ethnic minorities in the Netherlands

    NARCIS (Netherlands)

    Hosper, K.; Nicolaou, M.; van Valkengoed, I.; Nierkens, V.; Stronks, K.

    2011-01-01

    ABSTRACT: BACKGROUND: The prevalence of overweight appears to vary in people of first and second generation ethnic minority groups. Insight into the factors that underlie these weight differences might help in understanding the health transition that is taking place across generations following migr

  1. Recent Development of the Second and Third Generation Irreversible Epidermal Growth Factor Receptor Inhibitors.

    Science.gov (United States)

    Han, Weiwei; Du, Yongli

    2017-07-01

    Recent reports suggested that essential directions for new lung cancer, breast carcinoma therapies, as well as the roomier realm of targeted cancer therapies were provided through targeting the epidermal growth factor receptor (EGFR). Patients who carrying non-small cell lung carcinoma (NSCLC) with activating mutations in EGFR initially respond well to the EGFR inhibitors erlotinib and gefitinib, which were located the active site of the EGFR kinase and designed to act as competitive inhibitors of combining with the ATP. However, patients who were treated with the erlotinib and gefitinib will relapse because of the emergence of drug-resistant mutations, with T790M mutations accounting for approximately 60% of all resistance. In order to overcome drug resistance, Pharmaceutical chemistry experts recently devoted great endeavors to the development of second-generation irreversible selective inhibitors which covalently modify Cys797 or Cys773 at the ATP binding cleft. Nevertheless, these inhibitors have not reached ideal effect of experts in patients with T790M positive mutation and apparently because of the dose-limiting toxicities associated with inhibition of wild type EGFR. A novel class of 'third generation' EGFR TKIs have been developed that is sensitising and T790M mutant-specific whilst sparing WT EGFR, representing a significant breakthrough in the treatment in NSCLC patients with acquired resistance harboring these genotypes. Herein, we provides an overview of the second and third generation inhibitors currently approved, in clinical trial and also encompasses novel structures of discovery. This review mainly focuses on drug resistance, their mechanisms of action, development of structure-activity relationships and binding modes. © 2017 Wiley-VHCA AG, Zurich, Switzerland.

  2. Analytic standard errors for exploratory process factor analysis.

    Science.gov (United States)

    Zhang, Guangjian; Browne, Michael W; Ong, Anthony D; Chow, Sy Miin

    2014-07-01

    Exploratory process factor analysis (EPFA) is a data-driven latent variable model for multivariate time series. This article presents analytic standard errors for EPFA. Unlike standard errors for exploratory factor analysis with independent data, the analytic standard errors for EPFA take into account the time dependency in time series data. In addition, factor rotation is treated as the imposition of equality constraints on model parameters. Properties of the analytic standard errors are demonstrated using empirical and simulated data.

  3. A replication of a factor analysis of motivations for trapping

    Science.gov (United States)

    Schroeder, Susan; Fulton, David C.

    2015-01-01

    Using a 2013 sample of Minnesota trappers, we employed confirmatory factor analysis to replicate an exploratory factor analysis of trapping motivations conducted by Daigle, Muth, Zwick, and Glass (1998).  We employed the same 25 items used by Daigle et al. and tested the same five-factor structure using a recent sample of Minnesota trappers. We also compared motivations in our sample to those reported by Daigle et el.

  4. Generation and gene expression profiling of 48 transcription-factor-inducible mouse embryonic stem cell lines

    Science.gov (United States)

    Yamamizu, Kohei; Sharov, Alexei A.; Piao, Yulan; Amano, Misa; Yu, Hong; Nishiyama, Akira; Dudekula, Dawood B.; Schlessinger, David; Ko, Minoru S. H.

    2016-01-01

    Mouse embryonic stem cells (ESCs) can differentiate into a wide range – and possibly all cell types in vitro, and thus provide an ideal platform to study systematically the action of transcription factors (TFs) in cell differentiation. Previously, we have generated and analyzed 137 TF-inducible mouse ESC lines. As an extension of this “NIA Mouse ESC Bank,” we generated and characterized 48 additional mouse ESC lines, in which single TFs in each line could be induced in a doxycycline-controllable manner. Together, with the previous ESC lines, the bank now comprises 185 TF-manipulable ESC lines (>10% of all mouse TFs). Global gene expression (transcriptome) profiling revealed that the induction of individual TFs in mouse ESCs for 48 hours shifts their transcriptomes toward specific differentiation fates (e.g., neural lineages by Myt1 Isl1, and St18; mesodermal lineages by Pitx1, Pitx2, Barhl2, and Lmx1a; white blood cells by Myb, Etv2, and Tbx6, and ovary by Pitx1, Pitx2, and Dmrtc2). These data also provide and lists of inferred target genes of each TF and possible functions of these TFs. The results demonstrate the utility of mouse ESC lines and their transcriptome data for understanding the mechanism of cell differentiation and the function of TFs. PMID:27150017

  5. Phantom-based ground-truth generation for cerebral vessel segmentation and pulsatile deformation analysis

    Science.gov (United States)

    Schetelig, Daniel; Säring, Dennis; Illies, Till; Sedlacik, Jan; Kording, Fabian; Werner, René

    2016-03-01

    Hemodynamic and mechanical factors of the vascular system are assumed to play a major role in understanding, e.g., initiation, growth and rupture of cerebral aneurysms. Among those factors, cardiac cycle-related pulsatile motion and deformation of cerebral vessels currently attract much interest. However, imaging of those effects requires high spatial and temporal resolution and remains challenging { and similarly does the analysis of the acquired images: Flow velocity changes and contrast media inflow cause vessel intensity variations in related temporally resolved computed tomography and magnetic resonance angiography data over the cardiac cycle and impede application of intensity threshold-based segmentation and subsequent motion analysis. In this work, a flow phantom for generation of ground-truth images for evaluation of appropriate segmentation and motion analysis algorithms is developed. The acquired ground-truth data is used to illustrate the interplay between intensity fluctuations and (erroneous) motion quantification by standard threshold-based segmentation, and an adaptive threshold-based segmentation approach is proposed that alleviates respective issues. The results of the phantom study are further demonstrated to be transferable to patient data.

  6. “80”后知识型员工组织承诺行为一致性研究--基于贝叶斯估计模型和因子分析法的实证分析%The Consistency of the Organizational Commitment Behavior on 80 ’ s Generation Knowledge Employees---A Study based on Empirical Analysis of Bayes Estimate Model and Factor Analysis

    Institute of Scientific and Technical Information of China (English)

    张超; 卢洋; 温小郑

    2015-01-01

    As 80 ’ s generation become the main force of enterprise human resources .The study which fo-cus on organization activity about 80 ’ s generation has become a hot spot .This article , using the method of questionnaire survey on skilled employee , Pearson&Spearman ratio and factor analysis and Bayes esti-mate model ,illustrates the relationship between organizational commitment and job performance about 80 ’ s generation.We can draw the following conclusions:(1)Emotional commitment has strong positive rela-tionship with contextual performance and task performance;( 2 ) Continual commitment contributes side effect to task performance and has feeble positive relationship with contextual performance;(3)Normative commitment and has strong positive relationship with task performance and contextual performance .%随着“80后”这一代人走向社会成为企业人力资源的主力军,关于“80后”人员的组织行为研究成为热点。本文数据来自对企业组织中“80后”知识型员工的组织行为的问卷调查,采用因子分析、Bayes 估计、Pearson、Spearman相关系数方法对组织承诺和工作绩效的关系进行分析,结果表明:(1)情感承诺与关系绩效和任务绩效存在强的正相关关系;(2)持续承诺对任务绩效有负影响与关系绩效存在弱的正相关关系;(3)规范承诺与关系绩效和任务绩效存在较强的正相关关系。

  7. Exploring factors that influence work analysis data: A meta-analysis of design choices, purposes, and organizational context.

    Science.gov (United States)

    DuVernet, Amy M; Dierdorff, Erich C; Wilson, Mark A

    2015-09-01

    Work analysis is fundamental to designing effective human resource systems. The current investigation extends previous research by identifying the differential effects of common design decisions, purposes, and organizational contexts on the data generated by work analyses. The effects of 19 distinct factors that span choices of descriptor, collection method, rating scale, and data source, as well as project purpose and organizational features, are explored. Meta-analytic results cumulated from 205 articles indicate that many of these variables hold significant consequences for work analysis data. Factors pertaining to descriptor choice, collection method, rating scale, and the purpose for conducting the work analysis each showed strong associations with work analysis data. The source of the work analysis information and organizational context in which it was conducted displayed fewer relationships. Findings can be used to inform choices work analysts make about methodology and postcollection evaluations of work analysis information.

  8. Generator Coordinate Method Analysis of Xe and Ba Isotopes

    Science.gov (United States)

    Higashiyama, Koji; Yoshinaga, Naotaka; Teruya, Eri

    Nuclear structure of Xe and Ba isotopes is studied in terms of the quantum-number projected generator coordinate method (GCM). The GCM reproduces well the energy levels of high-spin states as well as low-lying states. The structure of the low-lying states is analyzed through the GCM wave functions.

  9. An introduction to metagenomic data generation, analysis, visualization, and interpretation

    Science.gov (United States)

    As discussed in virtually every chapter of this book, the emergence of next-generation sequencing technology in the last decade has revolutionized the field of forensic microbiology and decomposition ecology. Because of such technological developments, we now recognize that 10^10 and 10^14 bacteria...

  10. Disintermediation and User-generated Content: A Latent Segmentation Analysis

    NARCIS (Netherlands)

    Del Chiappa, Giacomo; Lorenzo Romero, Carlota; Constantinides, Efthymios

    2014-01-01

    This research investigates the perceptions of different groups of consumers for and against the disintermediation of travel agencies also considering the relative power in influencing the tourist's choices exerted by user generated-content (UGC). A web-based survey is carried out in Spain and 961

  11. Resonance analysis in parallel voltage-controlled Distributed Generation inverters

    DEFF Research Database (Denmark)

    Wang, Xiongfei; Blaabjerg, Frede; Chen, Zhe

    2013-01-01

    Thanks to the fast responses of the inner voltage and current control loops, the dynamic behaviors of parallel voltage-controlled Distributed Generation (DG) inverters not only relies on the stability of load sharing among them, but subjects to the interactions between the voltage control loops o...

  12. Temperature Fluctuation Characteristics Analysis for Steam Generator of Fast Reactor

    Institute of Scientific and Technical Information of China (English)

    ZHU; Li-na; WU; Zhi-guang

    2015-01-01

    In the case of boiling heat transfer deterioration,temperature fluctuating may accelerate the corrosion of heat transfer tubes and can also lead to thermal stress on the tubes.In this paper,dryout-induced temperature fluctuation for the fast reactor steam generator is investigated.The impacts of water flow rate,sodium inlet temperature and the outlet steam

  13. Disintermediation and User-generated Content: A Latent Segmentation Analysis

    NARCIS (Netherlands)

    Chiappa, Del Giacomo; Lorenzo-Romero, Carlota; Constantinides, E.

    2014-01-01

    This research investigates the perceptions of different groups of consumers for and against the disintermediation of travel agencies also considering the relative power in influencing the tourist's choices exerted by user generated-content (UGC). A web-based survey is carried out in Spain and 961 co

  14. Analysis of Interaction Factors Between Two Piles

    Institute of Scientific and Technical Information of China (English)

    CAO Ming; CHEN Long-zhu

    2008-01-01

    A rigorous analytical method is presented for calculating the interaction factor between two identical piles subjected to vertical loads. Following the technique proposed by Muki and Sternberg, the problem is decomposed into an extended soil mass and two fictitious piles characterized respectively by Young's modulus of the soil and that of the difference between the pile and soil. The unknown axial forces along fictitious piles are determined by solving a Fredholm integral equation of the second kind, which imposes the compatibility condition that the axial strains of the fictitious piles are equal to those corresponding to the centroidal axes of the extended soil. The real pile forces and displacements can subequally be calculated based on the determined fictitious pile forces, and finally, the desired pile interaction factors may be obtained. Results confirm the validity of the proposed approach and portray the influence of the governing parameters on the pile interaction.

  15. Analysis of factors affecting fattening of chickens

    OpenAIRE

    OBERMAJEROVÁ, Barbora

    2013-01-01

    Poultry meat belongs to the basic assortment of human nutrition. The meat of an intensively fattened poultry is a source of easily digestible proteins, lipids, mineral substances and vitamins. The aim of this bachelor´s thesis was to write out a literature review, which is focused on the intensity of growth, carcass yield, quality and composition of broiler chickens meat. The following describes the internal and external factors that affect them, i.e. genetic foundation, hybrid combination, s...

  16. Numerical Analysis of Flow Field in Generator End-Winding Region

    Directory of Open Access Journals (Sweden)

    Wei Tong

    2008-01-01

    Full Text Available Cooling in an end-winding region of a high-powered, large-sized generator still remains a challenge today because of a number of factors: a larger number of parts/components with irregular geometries, complexity in cooling flow paths, flow splitting and mixing, and interactions between rotor-induced rotating flows and nonrotating flows from stationary sections. One of the key challenges is to model cooling flows passing through armature bars, which are made up of bundles of strands of insulated copper wires and are bent oppositely to cross each other. This work succeeded in modeling a complex generator end-winding region with great efforts to simplify the model by treating the armature bar region as a porous medium. The flow and pressure fields at the end-winding region were investigated numerically using an axial symmetric computational fluid dynamics (CFD model. Based on the analysis, the cooling flow rate at each flow branch (rotor-stator gap, rotor subslot, outside space block, and small ventilation holes to the heat exchanger was determined, and the high-pressure gradient zones were identified. The CFD results have been successfully used to optimize the flow path configuration for improving the generator operation performance, and the control of the cooling flow, as well as minimizing windage losses and flow-introduced noises.

  17. Using open data in near real time disaster analysis and knowledge generation

    Science.gov (United States)

    She, Jun

    2017-04-01

    This presentation will address the value of using open operational geo data in near real time disaster analysis and knowledge generation. In the past, mechanism analysis of a meteo-hyrological extreme event may take month and years with lots of resources since there exist many kinds of restrictions on the model and observation data, e.g., in availability, accessibility, adequacy in resolution, quality and delivery time etc. In recent years, thanks to the open data and open service programs such as Copernicus, EMODnet (European Marine Observation Data Network) and data sharing activities in ROOSs (Regional Operational Oceanography Systems) and national agencies, the disaster analysis become a much faster and efficient procedure. The study will present such a case study for analyzing a hundred-year storm event in January 2017 which affects Danish and German coasts in western Baltic Sea. The event and its forecasts have caused lots of attention in Danish and German media. However, the explanations on how the storm surge is formed and why the prediction is good or bad in this or that country are still largely absent in the media reports. All the data and plots used in the analysis are from open sources. It is found that with the open data, the spatiotemporal variation and the internal links between weather, sea level and water mass movements can be well understood. New knowledge on key factors for the unusual high waters in the western Baltic is obtained from this analysis. Finally, recommendations for using open operational data in generating open science are given.

  18. Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

    Directory of Open Access Journals (Sweden)

    Soham Chanda

    2014-08-01

    Full Text Available Direct conversion of nonneural cells to functional neurons holds great promise for neurological disease modeling and regenerative medicine. We previously reported rapid reprogramming of mouse embryonic fibroblasts (MEFs into mature induced neuronal (iN cells by forced expression of three transcription factors: ASCL1, MYT1L, and BRN2. Here, we show that ASCL1 alone is sufficient to generate functional iN cells from mouse and human fibroblasts and embryonic stem cells, indicating that ASCL1 is the key driver of iN cell reprogramming in different cell contexts and that the role of MYT1L and BRN2 is primarily to enhance the neuronal maturation process. ASCL1-induced single-factor neurons (1F-iN expressed mature neuronal markers, exhibited typical passive and active intrinsic membrane properties, and formed functional pre- and postsynaptic structures. Surprisingly, ASCL1-induced iN cells were predominantly excitatory, demonstrating that ASCL1 is permissive but alone not deterministic for the inhibitory neuronal lineage.

  19. Investigating product development strategy in beverage industry using factor analysis

    Directory of Open Access Journals (Sweden)

    Naser Azad

    2013-03-01

    Full Text Available Selecting a product development strategy that is associated with the company's current service or product innovation, based on customers’ needs and changing environment, plays an important role in increasing demand, increasing market share, increasing sales and profits. Therefore, it is important to extract effective variables associated with product development to improve performance measurement of firms. This paper investigates important factors influencing product development strategies using factor analysis. The proposed model of this paper investigates 36 factors and, using factor analysis, we extract six most influential factors including information sharing, intelligence information, exposure strategy, differentiation, research and development strategy and market survey. The first strategy, partnership, includes five sub-factor including product development partnership, partnership with foreign firms, customers’ perception from competitors’ products, Customer involvement in product development, inter-agency coordination, customer-oriented approach to innovation and transmission of product development change where inter-agency coordination has been considered the most important factor. Internal strengths are the most influential factors impacting the second strategy, intelligence information. The third factor, introducing strategy, introducing strategy, includes four sub criteria and consumer buying behavior is the most influencing factor. Differentiation is the next important factor with five components where knowledge and expertise in product innovation is the most important one. Research and development strategy with four sub-criteria where reducing product development cycle plays the most influential factor and finally, market survey strategy is the last important factor with three factors and finding new market plays the most important role.

  20. Lyso-Sulfatide Binds Factor Xa and Inhibits Thrombin Generation by the Prothrombinase Complex.

    Directory of Open Access Journals (Sweden)

    Subramanian Yegneswaran

    Full Text Available Blood coagulation reactions are strongly influenced by phospholipids, but little is known about the influence of sphingolipids on coagulation mechanisms. Lysosulfatide (lyso-SF (sulfogalactosyl sphingosine prolonged factor Xa (fXa 1-stage plasma clotting assays, showing it had robust anticoagulant activity. In studies using purified clotting factors, lyso-SF inhibited >90% of prothrombin (II activation for reaction mixtures containing fXa/factor Va (fVa/II, and also inhibited II activation generation by fXa/ phospholipids and by Gla-domainless-fXa/fVa/phospholipids. When lyso-SF analogs were tested, results showed that N-acetyl-sulfatide was not anticoagulant, implying that the free amine group was essential for the anticoagulant effects of lyso-SF. Lyso-SF did not inhibit fXa enzymatic hydrolysis of small peptide substrates, showing it did not directly inhibit the fXa activity. In surface plasmon resonance studies, lyso-SF bound to immobilized inactivated fXa as well as inactivated Gla-domainless-fXa. Confirming this lyso-SF:fXa interaction, fluorescence studies showed that fluorescently-labeled-fXa in solution bound to lyso-SF. Thus, lyso-SF is an anticoagulant lipid that inhibits fXa when this enzyme is bound to either phospholipids or to fVa. Mechanisms for inhibition of procoagulant activity are likely to involve lyso-SF binding to fXa domain(s that are distinct from the fXa Gla domain. This suggests that certain sphingolipids, including lyso-SF and some of its analogs, may down-regulate fXa activity without inhibiting the enzyme's active site or binding to the fXa Gla domain.

  1. Housing Price Forecastability: A Factor Analysis

    DEFF Research Database (Denmark)

    Bork, Lasse; Møller, Stig Vinther

    2016-01-01

    We examine U.S. housing price forecastability using principal component analysis (PCA), partial least squares (PLS), and sparse PLS (SPLS). We incorporate information from a large panel of 128 economic time series and show that macroeconomic fundamentals have strong predictive power for future...

  2. Housing price forecastability: A factor analysis

    DEFF Research Database (Denmark)

    Møller, Stig Vinther; Bork, Lasse

    2017-01-01

    We examine U.S. housing price forecastability using principal component analysis (PCA), partial least squares (PLS), and sparse PLS (SPLS). We incorporate information from a large panel of 128 economic time series and show that macroeconomic fundamentals have strong predictive power for future...

  3. Parallel architecture for rapid image generation and analysis

    Energy Technology Data Exchange (ETDEWEB)

    Nerheim, R.J.

    1987-01-01

    A multiprocessor architecture inspired by the Disney multiplane camera is proposed. For many applications, this approach produces a natural mapping of processors to objects in a scene. Such a mapping promotes parallelism and reduces the hidden-surface work with minimal interprocessor communication and low-overhead cost. Existing graphics architectures store the final picture as a monolithic entity. The architecture here stores each object's image separately. It assembles the final composite picture from component images only when the video display needs to be refreshed. This organization simplifies the work required to animate moving objects that occlude other objects. In addition, the architecture has multiple processors that generate the component images in parallel. This further shortens the time needed to create a composite picture. In addition to generating images for animation, the architecture has the ability to decompose images.

  4. Thermal analysis of solar biomass hybrid co-generation plants

    Science.gov (United States)

    Kaushika, N. D.; Mishra, Anuradha; Chakravarty, M. N.

    2005-12-01

    This article describes a co-generation plant based on the biogas being produced from the waste of distillery plant and highlights the possible configuration in which the plant can be hybridized with auxiliary solar energy source having the advantage of using financial incentives in several countries. In hybridization, the solar heat is used for heating the boiler feed water. The solar heat-generating unit consists of line focus parabolic trough collector, heat transportation system and heat delivery unit such as heat exchanger. The simulation model of heat and mass transfer processes in the solar field as well as the balance of the system is developed to investigate the technological feasibility of the concept in terms of plant yield and matching of subsystems.

  5. Oxygen rich gas generator design and performance analysis

    Science.gov (United States)

    Gloyer, P. W.; Knuth, W. H.; Crawford, R. A.

    1993-01-01

    The present oxygen-rich combustion research investigates oxygen gas generator concepts. The theoretical and modeling aspects of a selected concept are presented, together with a refined concept resulting from the findings of the study. This investigation examined a counter-flow gas generator design for O2/H2 mass ratios of 100-200, featuring a near-stoichiometric combustion zone followed by downstream mixing. The critical technologies required to develop a performance model are analyzed and include the following: (1) oxygen flow boiling; (2) two-phase oxygen flow heat transfer; (3) film-cooling in the combustion zone; (4) oxygen-rich combustion with hydrogen; and (5) mixing and dilution.

  6. Dynamic Analysis of Permanent Magnet Synchronous Generator with Power Electronics

    Directory of Open Access Journals (Sweden)

    OZCIRA, S.

    2010-05-01

    Full Text Available Permanent magnet DC motor-generators (PMDC, PMSG have been widely used in industrial and energy sectors recently. Power control of these systems can be achieved by controlling the output voltage. In this study, PMDC-PMSG systems are mathematically modeled and simulated in MATLAB and Simulink software. Then the results are discussed. A low power permanent magnet synchronous generator is driven by a permanent magnet DC motor and the output voltage is controlled by a frequency cycle-converter. The output of a half-wave uncontrolled rectifier is applied to an SPWM inverter and the power is supplied to a 300V, 50Hz load. The load which is connected to an LC filter is modeled by state-space equations. LC filter is utilized in order to suppress the voltage oscillations at the inverter output.

  7. Changing Analysis Approach on COSMO SKYMED Second Generation Spacecraft

    Science.gov (United States)

    Galgani, G.; Antonelli, M.; Bandinelli, M.; Scione, E.; Scorzafava, E.

    2016-05-01

    The interaction of a space system with its orbital environment is a major consideration in the design of any space system, since a variety of hazards are associated with the operation of spacecraft in the harsh space environment. The COSMO second generation satellites cross the Low Earth Orbit (LEO) that is usually considered less hazardous than high altitude geosynchronous (GEO) satellites, except when crossing the auroral oval where high energy low density plasma is encountered [1]. In this paper a prediction activity aimed to estimate the surface potentials of the COSMO 2nd generation satellite during the polar orbit is described. The free, open-source Spacecraft Plasma Interaction Software (SPIS) available for Spacecraft Plasma Interaction Network in Europe (SPINE) community [2] was applied to model satellite structures and materials, as well plasma environment and finally to evaluate the surfaces potentials.

  8. Design and analysis of highway windmill electric generation

    Directory of Open Access Journals (Sweden)

    Suresh Mashyal

    2014-07-01

    Full Text Available The work deals with designing a portable highway wind turbine, which is to be contribute towards the global trend in wind energy production in a feasible way. Wind turbines are traditionally employed in rural areas; the main goal the work is to design a wind turbine that can be used in cities. In particular, the turbines will use the wind draft created by vehicles on the highway to generate electricity. The idea is to offset the amount of pollution created by burning fossil fuels by introducing a potential source of clean energy. As the automobiles moves from highways/expressways, there is a creation of pressure column on both the sides of the road. This pressure column is created due to imbalance of high pressure/low pressure energy band created by the automobiles. Due to this pressure band wind flow and create pressure thrust. The pressure thrust is sufficient to generate electricity through designed wind turbine.

  9. Automated cardiac sarcomere analysis from second harmonic generation images

    Science.gov (United States)

    Garcia-Canadilla, Patricia; Gonzalez-Tendero, Anna; Iruretagoyena, Igor; Crispi, Fatima; Torre, Iratxe; Amat-Roldan, Ivan; Bijnens, Bart H.; Gratacos, Eduard

    2014-05-01

    Automatic quantification of cardiac muscle properties in tissue sections might provide important information related to different types of diseases. Second harmonic generation (SHG) imaging provides a stain-free microscopy approach to image cardiac fibers that, combined with our methodology of the automated measurement of the ultrastructure of muscle fibers, computes a reliable set of quantitative image features (sarcomere length, A-band length, thick-thin interaction length, and fiber orientation). We evaluated the performance of our methodology in computer-generated muscle fibers modeling some artifacts that are present during the image acquisition. Then, we also evaluated it by comparing it to manual measurements in SHG images from cardiac tissue of fetal and adult rabbits. The results showed a good performance of our methodology at high signal-to-noise ratio of 20 dB. We conclude that our automated measurements enable reliable characterization of cardiac fiber tissues to systematically study cardiac tissue in a wide range of conditions.

  10. Signs and symptoms of acute mania: a factor analysis

    Directory of Open Access Journals (Sweden)

    de Silva Varuni A

    2011-08-01

    Full Text Available Abstract Background The major diagnostic classifications consider mania as a uni-dimensional illness. Factor analytic studies of acute mania are fewer compared to schizophrenia and depression. Evidence from factor analysis suggests more categories or subtypes than what is included in the classification systems. Studies have found that these factors can predict differences in treatment response and prognosis. Methods The sample included 131 patients consecutively admitted to an acute psychiatry unit over a period of one year. It included 76 (58% males. The mean age was 44.05 years (SD = 15.6. Patients met International Classification of Diseases-10 (ICD-10 clinical diagnostic criteria for a manic episode. Patients with a diagnosis of mixed bipolar affective disorder were excluded. Participants were evaluated using the Young Mania Rating Scale (YMRS. Exploratory factor analysis (principal component analysis was carried out and factors with an eigenvalue > 1 were retained. The significance level for interpretation of factor loadings was 0.40. The unrotated component matrix identified five factors. Oblique rotation was then carried out to identify three factors which were clinically meaningful. Results Unrotated principal component analysis extracted five factors. These five factors explained 65.36% of the total variance. Oblique rotation extracted 3 factors. Factor 1 corresponding to 'irritable mania' had significant loadings of irritability, increased motor activity/energy and disruptive aggressive behaviour. Factor 2 corresponding to 'elated mania' had significant loadings of elevated mood, language abnormalities/thought disorder, increased sexual interest and poor insight. Factor 3 corresponding to 'psychotic mania' had significant loadings of abnormalities in thought content, appearance, poor sleep and speech abnormalities. Conclusions Our findings identified three clinically meaningful factors corresponding to 'elated mania', 'irritable mania

  11. Numerical Grid Generation and Potential Airfoil Analysis and Design

    Science.gov (United States)

    1988-01-01

    field vectors tangent to the coordinate curve passing across these surfaces. The most common form is transfinite interpolation, which is es- sentially an...interpolation between curves or surfaces rather than points. It is called " transfinite " because it matches coordinate values on an entire curve or...surface. For example, Erikson [5] applies transfinite interpolation for three -dimensional grid generation about wing - body configurations. Some

  12. SABATPG-A Structural Analysis Based Automatic Test Generation System

    Institute of Scientific and Technical Information of China (English)

    李忠诚; 潘榆奇; 闵应骅

    1994-01-01

    A TPG system, SABATPG, is given based on a generic structural model of large circuits. Three techniques of partial implication, aftereffect of identified undetectable faults and shared sensitization with new concepts of localization and aftereffect are employed in the system to improve FAN algorithm. Experiments for the 10 ISCAS benchmark circuits show that the computing time of SABATPG for test generation is 19.42% less than that of FAN algorithm.

  13. Design and Analysis of Tubular Permanent Magnet Linear Wave Generator

    Directory of Open Access Journals (Sweden)

    Jikai Si

    2014-01-01

    Full Text Available Due to the lack of mature design program for the tubular permanent magnet linear wave generator (TPMLWG and poor sinusoidal characteristics of the air gap flux density for the traditional surface-mounted TPMLWG, a design method and a new secondary structure of TPMLWG are proposed. An equivalent mathematical model of TPMLWG is established to adopt the transformation relationship between the linear velocity of permanent magnet rotary generator and the operating speed of TPMLWG, to determine the structure parameters of the TPMLWG. The new secondary structure of the TPMLWG contains surface-mounted permanent magnets and the interior permanent magnets, which form a series-parallel hybrid magnetic circuit, and their reasonable structure parameters are designed to get the optimum pole-arc coefficient. The electromagnetic field and temperature field of TPMLWG are analyzed using finite element method. It can be included that the sinusoidal characteristics of air gap flux density of the new secondary structure TPMLWG are improved, the cogging force as well as mechanical vibration is reduced in the process of operation, and the stable temperature rise of generator meets the design requirements when adopting the new secondary structure of the TPMLWG.

  14. Design and analysis of tubular permanent magnet linear wave generator.

    Science.gov (United States)

    Si, Jikai; Feng, Haichao; Su, Peng; Zhang, Lufeng

    2014-01-01

    Due to the lack of mature design program for the tubular permanent magnet linear wave generator (TPMLWG) and poor sinusoidal characteristics of the air gap flux density for the traditional surface-mounted TPMLWG, a design method and a new secondary structure of TPMLWG are proposed. An equivalent mathematical model of TPMLWG is established to adopt the transformation relationship between the linear velocity of permanent magnet rotary generator and the operating speed of TPMLWG, to determine the structure parameters of the TPMLWG. The new secondary structure of the TPMLWG contains surface-mounted permanent magnets and the interior permanent magnets, which form a series-parallel hybrid magnetic circuit, and their reasonable structure parameters are designed to get the optimum pole-arc coefficient. The electromagnetic field and temperature field of TPMLWG are analyzed using finite element method. It can be included that the sinusoidal characteristics of air gap flux density of the new secondary structure TPMLWG are improved, the cogging force as well as mechanical vibration is reduced in the process of operation, and the stable temperature rise of generator meets the design requirements when adopting the new secondary structure of the TPMLWG.

  15. Analysis of entropy extraction efficiencies in random number generation systems

    Science.gov (United States)

    Wang, Chao; Wang, Shuang; Chen, Wei; Yin, Zhen-Qiang; Han, Zheng-Fu

    2016-05-01

    Random numbers (RNs) have applications in many areas: lottery games, gambling, computer simulation, and, most importantly, cryptography [N. Gisin et al., Rev. Mod. Phys. 74 (2002) 145]. In cryptography theory, the theoretical security of the system calls for high quality RNs. Therefore, developing methods for producing unpredictable RNs with adequate speed is an attractive topic. Early on, despite the lack of theoretical support, pseudo RNs generated by algorithmic methods performed well and satisfied reasonable statistical requirements. However, as implemented, those pseudorandom sequences were completely determined by mathematical formulas and initial seeds, which cannot introduce extra entropy or information. In these cases, “random” bits are generated that are not at all random. Physical random number generators (RNGs), which, in contrast to algorithmic methods, are based on unpredictable physical random phenomena, have attracted considerable research interest. However, the way that we extract random bits from those physical entropy sources has a large influence on the efficiency and performance of the system. In this manuscript, we will review and discuss several randomness extraction schemes that are based on radiation or photon arrival times. We analyze the robustness, post-processing requirements and, in particular, the extraction efficiency of those methods to aid in the construction of efficient, compact and robust physical RNG systems.

  16. Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.

    Science.gov (United States)

    Steeland, Sophie; Puimège, Leen; Vandenbroucke, Roosmarijn E; Van Hauwermeiren, Filip; Haustraete, Jurgen; Devoogdt, Nick; Hulpiau, Paco; Leroux-Roels, Geert; Laukens, Debby; Meuleman, Philip; De Vos, Martine; Libert, Claude

    2015-02-13

    The cytokine TNF is a well known drug target for several inflammatory diseases such as Crohn disease. Despite the great success of TNF blockers, therapy could be improved because of high costs and side effects. Selective inhibition of TNF receptor (TNFR) 1 signaling holds the potential to greatly reduce the pro-inflammatory activity of TNF, thereby preserving the advantageous immunomodulatory signals mediated by TNFR2. We generated a selective human TNFR1 inhibitor based on Nanobody (Nb) technology. Two anti-human TNFR1 Nbs were linked with an anti-albumin Nb to generate Nb Alb-70-96 named "TNF Receptor-One Silencer" (TROS). TROS selectively binds and inhibits TNF/TNFR1 and lymphotoxin-α/TNFR1 signaling with good affinity and IC50 values, both of which are in the nanomolar range. Surface plasmon resonance analysis reveals that TROS competes with TNF for binding to human TNFR1. In HEK293T cells, TROS strongly reduces TNF-induced gene expression, like IL8 and TNF, in a dose-dependent manner; and in ex vivo cultured colon biopsies of CD patients, TROS inhibits inflammation. Finally, in liver chimeric humanized mice, TROS antagonizes inflammation in a model of acute TNF-induced liver inflammation, reflected in reduced human IL8 expression in liver and reduced IL6 levels in serum. These results demonstrate the considerable potential of TROS and justify the evaluation of TROS in relevant disease animal models of both acute and chronic inflammation and eventually in patients.

  17. Factors Effecting Unemployment: A Cross Country Analysis

    Directory of Open Access Journals (Sweden)

    Aurangzeb

    2013-01-01

    Full Text Available This paper investigates macroeconomic determinants of the unemployment for India, China and Pakistan for the period 1980 to 2009. The investigation was conducted through co integration, granger causality and regression analysis. The variables selected for the study are unemployment, inflation, gross domestic product, exchange rate and the increasing rate of population. The results of regression analysis showed significant impact of all the variables for all three countries. GDP of Pakistan showed positive relation with the unemployment rate and the reason of that is the poverty level and underutilization of foreign investment. The result of granger causality showed that bidirectional causality does not exist between any of the variable for all three countries. Co integration result explored that long term relationship do exist among the variables for all the models. It is recommended that distribution of income needs to be improved for Pakistan in order to have positive impact of growth on the employment rate.

  18. Enlistment Decisions of the Millennial Generation: An Analysis of Micro-Level Data

    Science.gov (United States)

    2007-09-01

    in Culture and Power 13: 53-53-72. Raines, Claire. Generations at work: Managing millenials . 2002 [cited July 13, 2007]. Available from http...THE MILLENNIAL GENERATION : AN ANALYSIS OF MICRO-LEVEL DATA by Kevin M. Halfacre September 2007 Thesis Advisor: Stephen Mehay Co...TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Enlistment Decisions of the Millennial Generation : An Analysis of Micro-Level Data 6

  19. Explanatory factors for first and second-generation non-western women's inadequate prenatal care utilisation: a prospective cohort study.

    Science.gov (United States)

    Boerleider, Agatha W; Manniën, Judith; van Stenus, Cherelle M V; Wiegers, Therese A; Feijen-de Jong, Esther I; Spelten, Evelien R; Devillé, Walter L J M

    2015-04-21

    Little research into non-western women's prenatal care utilisation in industrialised western countries has taken generational differences into account. In this study we examined non-western women's prenatal care utilisation and its explanatory factors according to generational status. Data from 3300 women participating in a prospective cohort of primary midwifery care clients (i.e. women with no complications or no increased risk for complications during pregnancy, childbirth and the puerperium who receive maternity care by autonomous midwives) in the Netherlands (the DELIVER study) was used. Gestational age at entry and the total number of prenatal visits were aggregated into an index. The extent to which potential factors explained non-western women's prenatal care utilisation was assessed by means of blockwise logistic regression analyses and percentage changes in odds ratios. The unadjusted odds of first and second-generation non-western women making inadequate use of prenatal care were 3.26 and 1.96 times greater than for native Dutch women. For the first generation, sociocultural factors explained 43% of inadequate prenatal care utilisation, socioeconomic factors explained 33% and demographic and pregnancy factors explained 29%. For the second generation, sociocultural factors explained 66% of inadequate prenatal care utilisation. Irrespective of generation, strategies to improve utilisation should focus on those with the following sociocultural characteristics (not speaking Dutch at home, no partner or a first-generation non-Dutch partner). For the first generation, strategies should also focus on those with the following demographic, pregnancy and socioeconomic characteristics (aged ≤ 19 or ≥ 36, unplanned pregnancies, poor obstetric histories (extra-uterine pregnancy, molar pregnancy or abortion), a low educational level, below average net household income and no supplementary insurance.

  20. MULTIVARIATE STEPWISE LOGISTIC REGRESSION ANALYSIS ON RISK FACTORS OF VENTILATOR-ASSOCIATED PNEUMONIA IN COMPREHENSIVE ICU

    Institute of Scientific and Technical Information of China (English)

    管军; 杨兴易; 赵良; 林兆奋; 郭昌星; 李文放

    2003-01-01

    Objective To investigate the incidence, crude mortality and independent risk factors of ventilator-associated pneumonia (VAP) in comprehensive ICU in China.Methods The clinical and microbiological data were retrospectively collected and analysed of all the 97 patients receiving mechanical ventilation (>48hr) in our comprehensive ICU during 1999. 1 - 2000. 12. Firstly several statistically significant risk factors were screened out with univariate analysis, then independent risk factors were determined with multivariate stepwise logistic regression analysis.Results The incidence of VAP was 54. 64% (15. 60 cases per 1000 ventilation days), the crude mortality 47.42% . Interval between the establishment of artificial airway and diagnosis of VAP was 6.9 ± 4.3 d. Univariate analysis suggested that indwelling naso-gastric tube, corticosteroid, acid inhibitor, third-generation cephalosporin/ imipenem, non - infection lung disease, and extrapulmonary infection were the statistically significant risk factors of

  1. ANALYSIS OF RISK FACTORS ECTOPIC PREGNANCY

    Directory of Open Access Journals (Sweden)

    Budi Santoso

    2017-04-01

    Full Text Available Introduction: Ectopic pregnancy is a pregnancy with extrauterine implantation. This situation is gynecologic emergency that contributes to maternal mortality. Therefore, early recognition, based on identification of the causes of ectopic pregnancy risk factors, is needed. Methods: The design descriptive observational. The samples were pregnant women who had ectopic pregnancy at Maternity Room, Emergency Unit, Dr. Soetomo Hospital, Surabaya, from 1 July 2008 to 1 July 2010. Sampling technique was total sampling using medical records. Result: Patients with ectopic pregnancy were 99 individuals out of 2090 pregnant women who searched for treatment in Dr. Soetomo Hospital. However, only 29 patients were accompanied with traceable risk factors. Discussion:. Most ectopic pregnancies were in the age group of 26-30 years, comprising 32 patients (32.32%, then in age groups of 31–35 years as many as 25 patients (25.25%, 18 patients in age group 21–25 years (18.18%, 17 patients in age group 36–40 years (17.17%, 4 patients in age group 41 years and more (4.04%, and the least was in age group of 16–20 years with 3 patients (3.03%. A total of 12 patients with ectopic pregnancy (41.38% had experience of abortion and 6 patients (20.69% each in groups of patients with ectopic pregnancy who used family planning, in those who used family planning as well as ectopic pregnancy patients with history of surgery. There were 2 patients (6.90% of the group of patients ectopic pregnancy who had history of surgery and history of abortion. The incidence rate of ectopic pregnancy was 4.73%, mostly in the second gravidity (34.34%, whereas the nulliparous have the highest prevalence of 39.39%. Acquired risk factors, i.e. history of operations was 10.34%, patients with family planning 20.69%, patients with history of abortion 41.38%, patients with history of abortion and operation 6.90% patients with family and history of abortion was 20.69%.

  2. The potentials of the third generation of flow injection analysis for nutrient monitoring and fractionation analysis

    DEFF Research Database (Denmark)

    Miró, Manuel; Hansen, Elo Harald; Buanuam, Janya

    2006-01-01

    In the present communication, the third generation of flow injection analysis, the so-called micro sequential-injection Laboratory-on-Valve (μSI-LOV), is presented as a miniaturized, automated approach for on-line monitoring of nutrients in different environmental compartments as effected under...... enclosed and strictly controlled conditions. Special emphasis is placed on coupling μSI-LOV on-line with a recently developed microcolumn to perform dynamic fractionation schemes for ascertaining the availability of phosphorous forms in solid substrates for biota uptake under simulated environmental...

  3. Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design.

    Directory of Open Access Journals (Sweden)

    Ola Fjellström

    Full Text Available Activated factor XI (FXIa inhibitors are anticipated to combine anticoagulant and profibrinolytic effects with a low bleeding risk. This motivated a structure aided fragment based lead generation campaign to create novel FXIa inhibitor leads. A virtual screen, based on docking experiments, was performed to generate a FXIa targeted fragment library for an NMR screen that resulted in the identification of fragments binding in the FXIa S1 binding pocket. The neutral 6-chloro-3,4-dihydro-1H-quinolin-2-one and the weakly basic quinolin-2-amine structures are novel FXIa P1 fragments. The expansion of these fragments towards the FXIa prime side binding sites was aided by solving the X-ray structures of reported FXIa inhibitors that we found to bind in the S1-S1'-S2' FXIa binding pockets. Combining the X-ray structure information from the identified S1 binding 6-chloro-3,4-dihydro-1H-quinolin-2-one fragment and the S1-S1'-S2' binding reference compounds enabled structure guided linking and expansion work to achieve one of the most potent and selective FXIa inhibitors reported to date, compound 13, with a FXIa IC50 of 1.0 nM. The hydrophilicity and large polar surface area of the potent S1-S1'-S2' binding FXIa inhibitors compromised permeability. Initial work to expand the 6-chloro-3,4-dihydro-1H-quinolin-2-one fragment towards the prime side to yield molecules with less hydrophilicity shows promise to afford potent, selective and orally bioavailable compounds.

  4. 新生代农民工培训意愿影响因素再检验--来自重庆市调研数据的分析%Checking on Training Willingness and Its Influencing factors of New Generation Peasant Workers--Analysis on Investigating Data from Chongqing

    Institute of Scientific and Technical Information of China (English)

    胡美云; 曾国平

    2014-01-01

    综合人力资本和成本收益决策理论,构建新生代农民工培养意愿影响因素检验的Logistic模型,对重庆市新生代农民工调研数据的实证结果表明:影响新生代农民工培训意愿的因素较多,个人、工作、生活以及培训特征变量均包含影响培训意愿的因素;具有外出前培训经历或进城后培训经历的新生代农民工,相比没有相关培训经历的农民工,有更大的意愿继续参与培训;有无培训经历导致新生代农民工培训意愿的影响因素存在显著差异。培训供给主体在定位培训市场的潜在客户时,应重视新生代农民工的个体差异及有无相关培训经历的重要影响。%referring the human capital and cost-benefit theory,this paper analyzes the factors impacting training willing-ness of new generation peasants through the Logistic model,It is found that the training of new generation of migrant workers affected by many factors including personal,work,life and training characteristic variables;having training experi-ence of the new generation of migrant workers,compared with no relevant training experiences of migrant workers,have a greater willingness to continue participation in training;whether the influence factors of training experience leads to new generation of migrant workers training will exist significant differences.According to the results,the training institutes should pay attention to the personal difference and whether have training experience when provide training.

  5. Discourse analysis foucauldian perspective: Method and knowledge generation

    Directory of Open Access Journals (Sweden)

    Carlos González Domínguez

    2013-01-01

    Full Text Available Social Sciences finds in the discourse analysis a valuable tool, when it fosters its knowledge in different theoretical and methodological frames. However, turning to the discourse analysis is not predominant in this field. Scholars, who utilize it, are usually academicians who stem from certain disciplines such as Communication and Rhetoric Studies, or Language Sciences. Other social scientists, when intending to put the discourse analysis into practice, either theyignore it, confuse it, or they do not have the analytical resources to approach it. This is why our main interest in this paper aims at reflecting about the discourse analysis importance and its epistemological possibilities—especially, as a theoretical-methodological element of the Social Science development.

  6. Mod 1 wind turbine generator failure modes and effects analysis

    Science.gov (United States)

    1979-01-01

    A failure modes and effects analysis (FMEA) was directed primarily at identifying those critical failure modes that would be hazardous to life or would result in major damage to the system. Each subsystem was approached from the top down, and broken down to successive lower levels where it appeared that the criticality of the failure mode warranted more detail analysis. The results were reviewed by specialists from outside the Mod 1 program, and corrective action taken wherever recommended.

  7. Design analysis: Understanding e-waste recycling by generation Y

    OpenAIRE

    Zhang, Xiao; Wakkary, Ron

    2011-01-01

    This paper aims to understand e-waste recycling behavior of Generation Y. It presents a pilot study that explores this generation’s e-waste recycling practices, their attitudes towards ewaste recycling, and the barriers to e-waste recycling. The findings reveal the complexity of the actual e-waste recycling behavior, many participants in this study hold a positive attitude towards e-waste recycling, yet there is a shortage of convenient recycling options and e-waste recycling information. Bas...

  8. Kernel Principal Component Analysis for Stochastic Input Model Generation (PREPRINT)

    Science.gov (United States)

    2010-08-17

    c ( )d Fig. 13. Contour of saturation at 0.2 PVI : MC mean (a) and variance (b) from experimental samples; MC mean (c) and variance (d) from PC...realizations. The contour plots of saturation at 0.2 PVI are given in Fig. 13. PVI represents dimensionless time and is computed as PVI = ∫ Q dt/Vp...stochastic input model provides a fast way to generate many realizations, which are consistent, in a useful sense, with the experimental data. PVI M ea n

  9. Kinase genotype analysis of gastric gastrointestinal stromal tumor cytology samples using targeted next-generation sequencing.

    Science.gov (United States)

    Gleeson, Ferga C; Kipp, Benjamin R; Kerr, Sarah E; Voss, Jesse S; Graham, Rondell P; Campion, Michael B; Minot, Douglas M; Tu, Zheng J; Klee, Eric W; Lazaridis, Konstantinos N; Henry, Michael R; Levy, Michael J

    2015-01-01

    Gastric gastrointestinal stromal tumors (GISTs) usually contain the mast/stem cell growth factor receptor Kit gene (KIT) or platelet-derived growth factor receptor A (PDGFRA) mutations that can be targeted by, or mediate resistance to, imatinib. Diagnostic material often is obtained by endoscopic ultrasound-guided fine-needle aspiration, which often is unsuitable for molecular analysis. We investigated whether targeted next-generation sequencing (NGS) can be used in multiplex genotype analysis of cytology samples collected by endoscopic ultrasound-guided fine-needle aspiration. We used the Ion AmpliSeq V2 Cancer Hotspot NGS Panel (Life Technologies, Carlsbad, CA) to identify mutations in more than 2800 exons from 50 cancer-associated genes in GIST samples from 20 patients. We identified KIT mutations in 58% of samples (91% in exon 11 and 9% in exon 17) and PDGFRA mutations in 26% (60% in exon 18 and 40% in exon 12); 16% of samples had no mutations in KIT or PDGFRA. No pathogenic alterations were found in PIK3CA, BRAF, KRAS, NRAS, or FGFR3. We predicted that 32% of patients would have primary resistance to imatinib, based on mutations in exon 17 of KIT, exon 18 of PDGFRA (D842V), or no mutation in either gene. Targeted NGS of cytology samples from GISTs is feasible and provides clinically relevant data about kinase genotypes that can help guide individualized therapy.

  10. A survey on the human reliability analysis methods for the design of Korean next generation reactor

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Yong Hee; Lee, J. W.; Park, J. C.; Kwack, H. Y.; Lee, K. Y.; Park, J. K.; Kim, I. S.; Jung, K. W

    2000-03-01

    Enhanced features through applying recent domestic technologies may characterize the safety and efficiency of KNGR(Korea Next Generation Reactor). Human engineered interface and control room environment are expected to be beneficial to the human aspects of KNGR design. However, since the current method for human reliability analysis is not up to date after THERP/SHARP, it becomes hard to assess the potential of human errors due to both of the positive and negative effect of the design changes in KNGR. This is a state of the art report on the human reliability analysis methods that are potentially available for the application to the KNGR design. We surveyed every technical aspects of existing HRA methods, and compared them in order to obtain the requirements for the assessment of human error potentials within KNGR design. We categorized the more than 10 methods into the first and the second generation according to the suggestion of Dr. Hollnagel. THERP was revisited in detail. ATHEANA proposed by US NRC for an advanced design and CREAM proposed by Dr. Hollnagel were reviewed and compared. We conclude that the key requirements might include the enhancement in the early steps for human error identification and the quantification steps with considerations of more extended error shaping factors over PSFs(performance shaping factors). The utilization of the steps and approaches of ATHEANA and CREAM will be beneficial to the attainment of an appropriate HRA method for KNGR. However, the steps and data from THERP will be still maintained because of the continuity with previous PSA activities in KNGR design.

  11. Generation, analysis and functional annotation of expressed sequence tags from the ectoparasitic mite Psoroptes ovis

    Directory of Open Access Journals (Sweden)

    Kenyon Fiona

    2011-07-01

    Full Text Available Abstract Background Sheep scab is caused by Psoroptes ovis and is arguably the most important ectoparasitic disease affecting sheep in the UK. The disease is highly contagious and causes and considerable pruritis and irritation and is therefore a major welfare concern. Current methods of treatment are unsustainable and in order to elucidate novel methods of disease control a more comprehensive understanding of the parasite is required. To date, no full genomic DNA sequence or large scale transcript datasets are available and prior to this study only 484 P. ovis expressed sequence tags (ESTs were accessible in public databases. Results In order to further expand upon the transcriptomic coverage of P. ovis thus facilitating novel insights into the mite biology we undertook a larger scale EST approach, incorporating newly generated and previously described P. ovis transcript data and representing the largest collection of P. ovis ESTs to date. We sequenced 1,574 ESTs and assembled these along with 484 previously generated P. ovis ESTs, which resulted in the identification of 1,545 unique P. ovis sequences. BLASTX searches identified 961 ESTs with significant hits (E-value P. ovis ESTs. Gene Ontology (GO analysis allowed the functional annotation of 880 ESTs and included predictions of signal peptide and transmembrane domains; allowing the identification of potential P. ovis excreted/secreted factors, and mapping of metabolic pathways. Conclusions This dataset currently represents the largest collection of P. ovis ESTs, all of which are publicly available in the GenBank EST database (dbEST (accession numbers FR748230 - FR749648. Functional analysis of this dataset identified important homologues, including house dust mite allergens and tick salivary factors. These findings offer new insights into the underlying biology of P. ovis, facilitating further investigations into mite biology and the identification of novel methods of intervention.

  12. A Cost to Benefit Analysis of a Next Generation Electric Power Distribution System

    Science.gov (United States)

    Raman, Apurva

    This thesis provides a cost to benefit analysis of the proposed next generation of distribution systems- the Future Renewable Electric Energy Distribution Management (FREEDM) system. With the increasing penetration of renewable energy sources onto the grid, it becomes necessary to have an infrastructure that allows for easy integration of these resources coupled with features like enhanced reliability of the system and fast protection from faults. The Solid State Transformer (SST) and the Fault Isolation Device (FID) make for the core of the FREEDM system and have huge investment costs. Some key features of the FREEDM system include improved power flow control, compact design and unity power factor operation. Customers may observe a reduction in the electricity bill by a certain fraction for using renewable sources of generation. There is also a possibility of huge subsidies given to encourage use of renewable energy. This thesis is an attempt to quantify the benefits offered by the FREEDM system in monetary terms and to calculate the time in years required to gain a return on investments made. The elevated cost of FIDs needs to be justified by the advantages they offer. The result of different rates of interest and how they influence the payback period is also studied. The payback periods calculated are observed for viability. A comparison is made between the active power losses on a certain distribution feeder that makes use of distribution level magnetic transformers versus one that makes use of SSTs. The reduction in the annual active power losses in the case of the feeder using SSTs is translated onto annual savings in terms of cost when compared to the conventional case with magnetic transformers. Since the FREEDM system encourages operation at unity power factor, the need for installing capacitor banks for improving the power factor is eliminated and this reflects in savings in terms of cost. The FREEDM system offers enhanced reliability when compared to a

  13. Analysis of Translating Hydrofoil Power Generation Systems (Hydrokites)

    Science.gov (United States)

    McConnaghy, Kelsey

    The hydrokite is a novel hydro-power system that is based on emerging kite wind-energy systems which are currently being designed for use at high altitudes. The hydrokite system is comprised of a hydrofoil and a support system, and is designed to capture kinetic energy from the flow of a river while reducing negative impacts on the river ecology by minimally interfering with the rivers natural flow (i.e. no dams or river diversions are needed). This work presents some initial results which demonstrate the power performance capabilities of the hydrokite. Two different steady-state models for this system were studied to determine the effects of model parameters on power generation. A dynamic model was also developed and preliminary results are presented. These simplified initial models provide an upper bound for the power performance of an actual system as well as providing an understanding of the effects that parameter changes have on the system performance. This initial work shows that such a system could be a feasible, low impact method for generating renewable energy from low-head hydro sources.

  14. Next Generation Workload Management and Analysis System for Big Data

    Energy Technology Data Exchange (ETDEWEB)

    De, Kaushik [Univ. of Texas, Arlington, TX (United States)

    2017-04-24

    We report on the activities and accomplishments of a four-year project (a three-year grant followed by a one-year no cost extension) to develop a next generation workload management system for Big Data. The new system is based on the highly successful PanDA software developed for High Energy Physics (HEP) in 2005. PanDA is used by the ATLAS experiment at the Large Hadron Collider (LHC), and the AMS experiment at the space station. The program of work described here was carried out by two teams of developers working collaboratively at Brookhaven National Laboratory (BNL) and the University of Texas at Arlington (UTA). These teams worked closely with the original PanDA team – for the sake of clarity the work of the next generation team will be referred to as the BigPanDA project. Their work has led to the adoption of BigPanDA by the COMPASS experiment at CERN, and many other experiments and science projects worldwide.

  15. Social and cultural factors underlying generational differences in overweight: a cross-sectional study among ethnic minorities in the Netherlands

    Directory of Open Access Journals (Sweden)

    Nierkens Vera

    2011-02-01

    Full Text Available Abstract Background The prevalence of overweight appears to vary in people of first and second generation ethnic minority groups. Insight into the factors that underlie these weight differences might help in understanding the health transition that is taking place across generations following migration. We studied the role of social and cultural factors associated with generational differences in overweight among young Turkish and Moroccan men and women in the Netherlands. Methods Cross-sectional data were derived from the LASER-study in which information on health-related behaviour and socio-demographic factors, level of education, occupational status, acculturation (cultural orientation and social contacts, religious and migration-related factors was gathered among Turkish and Moroccan men (n = 334 and women (n = 339 aged 15-30 years. Participants were interviewed during a home visit. Overweight was defined as a Body Mass Index ≥ 25 kg/m2. Using logistic regression analyses, we tested whether the measured social and cultural factors could explain differences in overweight between first and second generation ethnic groups. Results Second generation women were less often overweight than first generation women (21.8% and 45.0% respectively, but this association was no longer significant when adjusting for the socioeconomic position (i.e. higher level of education of second generation women (Odds Ratio (OR = 0.77, 95%, Confidence Interval (CI 0.40-1.46. In men, we observed a reversed pattern: second generation men were more often overweight than first generation men (32.7% and 27.8%. This association (OR = 1.89, 95% CI 1.09-3.24 could not be explained by the social and cultural factors because none of these factors were associated with overweight among men. Conclusions The higher socio-economic position of second generation Turkish and Moroccan women may partly account for the lower prevalence of overweight in this group compared to first

  16. THEORY OF GENERATIONS AS A TOOL FOR ANALYSIS, FORMATION AND DEVELOPMENT OF LABOUR POTENTIAL

    Directory of Open Access Journals (Sweden)

    I. M. Gurova

    2016-01-01

    Full Text Available The modern Strauss–Howe generational theory created at the intersection of economic, sociological, historical and psychological Sciences. She focuses primarily on difference of attitudes of generations, due to the specific social environment, corresponding to a certain period of time. Such a perspective on issues related to the human factor in the economy, has recently attracted interest not only from researchers, but also finds application for solving practical problems in some fields of business.Subject / theme. The article is devoted to one of the urgent contemporary socio-economic problems – the issue of the formation and development of labor potential. In this context, the theory of generations is offered by the authors as a tool for the study of qualitative parameters of human resources and the planning of future work opportunities in our country. In particular, the article considers the main aspects of the classical version of the Strauss–Howe generational theory and its Russian adaptation. Statistics describing the General demographics and working population of Russia from the point of view of generational groups. On this basis, a forecast is made of the labor potential of the country in the long term structure, review and compare the basic values and business characteristics of its constituent generations. Problem areas for which use of generational approach is rational are revealed and the corresponding recommendations are made.Objectives. The purpose of this article is justification of the possible application of provisions of modern theories of generations to identify and predict the dynamics of qualitative characteristics of the domestic workforce, as well as the prospects of its use in order to control the formation and development of labor potential.Methods. Methodological basis of the presented work make comparative and economic-statistical and socio-cultural methods of analysis.Results. In the framework of this article

  17. Analysis of Software Test Item Generation- Comparison Between High Skilled and Low Skilled Engineers

    Institute of Scientific and Technical Information of China (English)

    Masayuki Hirayama; Osamu Mizuno; Tohru Kikuno

    2005-01-01

    Recent software system contain many functions to provide various services. According to this tendency, it is difficult to ensure software quality and to eliminate crucial faults by conventional software testing methods. So taking the effect of test engineer's skill on test item generation into consideration, we propose a new test item generation method,which supports the generation of test items for illegal behavior of the system. The proposed method can generate test items based on use-case analysis, deviation analysis for legal behavior, and faults tree analysis for system fault situations. From the results of the experimental applications of our method, we confirmed that test items for illegal behavior of a system were effectively generated, and also the proposed method could effectively assist test item generation by an engineer with low-level skill.

  18. Developing a New Approach for Arabic Morphological Analysis and Generation

    CERN Document Server

    Gridach, Mourad

    2011-01-01

    Arabic morphological analysis is one of the essential stages in Arabic Natural Language Processing. In this paper we present an approach for Arabic morphological analysis. This approach is based on Arabic morphological automaton (AMAUT). The proposed technique uses a morphological database realized using XMODEL language. Arabic morphology represents a special type of morphological systems because it is based on the concept of scheme to represent Arabic words. We use this concept to develop the Arabic morphological automata. The proposed approach has development standardization aspect. It can be exploited by NLP applications such as syntactic and semantic analysis, information retrieval, machine translation and orthographical correction. The proposed approach is compared with Xerox Arabic Analyzer and Smrz Arabic Analyzer.

  19. Whole system analysis of second generation bioenergy production and Ecosystem Services in Europe

    Science.gov (United States)

    Henner, Dagmar; Smith, Pete; Davies, Christian; McNamara, Niall

    2017-04-01

    Bioenergy crops are an important source of renewable energy and are a possible mechanism to mitigate global climate warming, by replacing fossil fuel energy that has higher greenhouse gas emissions. There is, however, uncertainty about the impacts of the growth of bioenergy crops on ecosystem services. This uncertainty is further enhanced by current climate change. It is important to establish how second generation bioenergy crops (Miscanthus, SRC willow and poplar) can contribute by closing the gap between reducing fossil fuel use and increasing the use of other renewable sources in a sustainable way. The project builds on models of energy crop production, biodiversity, soil impacts, greenhouse gas emissions and other ecosystem services, and on work undertaken in the UK on the ETI-funded ELUM project (www.elum.ac.uk). We will present estimated yields for the above named crops in Europe using the ECOSSE, DayCent, SalixFor and MiscanFor models. These yields will be brought into context with a whole system analysis, detailing trade-offs and synergies for land use change, food security, GHG emissions and soil and water security. Methods like water footprint tools, tourism value maps and ecosystem valuation tools and models (e.g. InVest, TEEB database, GREET LCA Model, World Business Council for Sustainable Development corporate ecosystem valuation, Millennium Ecosystem Assessment and the Ecosystem Services Framework) will be used to estimate and visualise the impacts of increased use of second generation bioenergy crops on the above named ecosystem services. The results will be linked to potential yields to generate "inclusion or exclusion areas" in Europe in order to establish suitable areas for bioenergy crop production and the extent of use possible. Policy is an important factor for using second generation bioenergy crops in a sustainable way. We will present how whole system analysis can be used to create scenarios for countries or on a continental scale. As an

  20. Analysis of Socio-Economic Factors Influencing Farmers' Adoption ...

    African Journals Online (AJOL)

    Analysis of Socio-Economic Factors Influencing Farmers' Adoption of Rice ... Farming experience, household size, farm size and extension contact ... gender, market availability, education, extension contact, labour availability and farm size.

  1. Exploring Technostress: Results of a Large Sample Factor Analysis

    Directory of Open Access Journals (Sweden)

    Steponas Jonušauskas

    2016-06-01

    Full Text Available With reference to the results of a large sample factor analysis, the article aims to propose the frame examining technostress in a population. The survey and principal component analysis of the sample consisting of 1013 individuals who use ICT in their everyday work was implemented in the research. 13 factors combine 68 questions and explain 59.13 per cent of the answers dispersion. Based on the factor analysis, questionnaire was reframed and prepared to reasonably analyze the respondents’ answers, revealing technostress causes and consequences as well as technostress prevalence in the population in a statistically validated pattern. A key elements of technostress based on factor analysis can serve for the construction of technostress measurement scales in further research.

  2. Risk Factor Analysis for Oral Precancer among Slum Dwellers in ...

    African Journals Online (AJOL)

    Rajasthan Dental College, Jaipur, Rajasthan, 1Dental Wing, All India Institute of Medical Sciences (AIIMS), Bhopal,. 4Department of Public ... Keywords: Oral cancer, Risk factor analysis, Slum dwellers. Access this .... hygiene aid used in India.

  3. Meta analysis of risk factors for colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    Kun Chen; Jiong-Liang Qiu; Yang Zhang; Yu-Wan Zhao

    2003-01-01

    AIM: To study the risk factors for colorectal cancer in China.METHODS: A meta-analysis of the risk factors of colorectal cancer was conducted for 14 case-control studies, and reviewed 14 reports within 13 years which included 5034cases and 5205 controls. Dersimonian and Laird random effective models were used to process the results.RESULTS: Meta analysis of the 14 studies demonstrated that proper physical activites and dietary fibers were protective factors (pooled OR<0.8), while fecal mucohemorrhage,chronic diarrhea and polyposis were highly associated with colorectal cancer (all pooled OR>4). The stratified results showed that different OR values of some factors were due to geographic factors or different resourses.CONCLUSION: Risks of colorectal cancer are significantly associated with the histories of intestinal diseases or relative symptoms, high lipid diet, emotional trauma and family history of cancers. The suitable physical activities and dietary fibers are protective factors.

  4. Text mining factor analysis (TFA) in green tea patent data

    Science.gov (United States)

    Rahmawati, Sela; Suprijadi, Jadi; Zulhanif

    2017-03-01

    Factor analysis has become one of the most widely used multivariate statistical procedures in applied research endeavors across a multitude of domains. There are two main types of analyses based on factor analysis: Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA). Both EFA and CFA aim to observed relationships among a group of indicators with a latent variable, but they differ fundamentally, a priori and restrictions made to the factor model. This method will be applied to patent data technology sector green tea to determine the development technology of green tea in the world. Patent analysis is useful in identifying the future technological trends in a specific field of technology. Database patent are obtained from agency European Patent Organization (EPO). In this paper, CFA model will be applied to the nominal data, which obtain from the presence absence matrix. While doing processing, analysis CFA for nominal data analysis was based on Tetrachoric matrix. Meanwhile, EFA model will be applied on a title from sector technology dominant. Title will be pre-processing first using text mining analysis.

  5. The impact of thrombin generation and rotation thromboelastometry on assessment of severity of factor XI deficiency.

    Science.gov (United States)

    Livnat, Tami; Shenkman, Boris; Martinowitz, Uri; Zivelin, Ariella; Dardik, Rima; Tamarin, Ilia; Mansharov, Rachel; Budnik, Ivan; Salomon, Ophira

    2015-08-01

    The phenotype of bleeding in patients with severe FXI deficiency is unpredictable and unlike other bleeding disorders, it is not directly correlated with levels of FXI. In this study we analyzed whether the global coagulation assays can serve as a clinical tool in predicting bleeding tendency in patients with severe FXI deficiency undergoing surgery, taking into account the large inter-individual variability of FXI levels and genotypes. Thrombin generation (TG) was measured in 39 platelet-poor plasma with or without tissue factor (TF) and in the presence or absence of corn trypsin inhibitor (CTI). Rotation thromboelastometry (ROTEM) was performed with fresh whole blood of 26 patients applying NATEM and INTEM tests. TG induced by recalcification can distinguish between bleeding and non-bleeding patients with severe FXI deficiency particularly among those with FXI activity of 2-20IU/dl. The addition of TF or TF and CTI to the TG assay masked the ability to differentiate between XI activity, genotype as well as bleeding and non-bleeding patients. ROTEM assays failed to distinguish bleeding from non-bleeding patients but could do so between different FXI activity levels and genotypes. In conclusion, in the current study we found a sensitive tool to distinguish between bleeding and non-bleeding patients. In order to recommend TG as a predictive tool for treatment tailoring, a larger patient group is required.

  6. Macrophage migration inhibitory factor induces autophagy via reactive oxygen species generation.

    Directory of Open Access Journals (Sweden)

    Yung-Chun Chuang

    Full Text Available Autophagy is an evolutionarily conserved catabolic process that maintains cellular homeostasis under stress conditions such as starvation and pathogen infection. Macrophage migration inhibitory factor (MIF is a multifunctional cytokine that plays important roles in inflammation and tumorigenesis. Cytokines such as IL-1β and TNF-α that are induced by MIF have been shown to be involved in the induction of autophagy. However, the actual role of MIF in autophagy remains unclear. Here, we have demonstrated that incubation of human hepatoma cell line HuH-7 cells with recombinant MIF (rMIF induced reactive oxygen species (ROS production and autophagy formation, including LC3-II expression, LC3 punctae formation, autophagic flux, and mitochondria membrane potential loss. The autophagy induced by rMIF was inhibited in the presence of MIF inhibitor, ISO-1 as well as ROS scavenger N-acetyl-L-cysteine (NAC. In addition, serum starvation-induced MIF release and autophagy of HuH-7 cells were partly blocked in the presence of NAC. Moreover, diminished MIF expression by shRNA transfection or inhibition of MIF by ISO-1 decreased serum starvation-induced autophagy of HuH-7 cells. Taken together, these data suggest that cell autophagy was induced by MIF under stress conditions such as inflammation and starvation through ROS generation.

  7. Energy system analysis of fuel cells and distributed generation

    DEFF Research Database (Denmark)

    Mathiesen, Brian Vad; Lund, Henrik

    2007-01-01

    on the energy system in which they are used. Consequently, coherent energy systems analyses of specific and complete energy systems must be conducted in order to evaluate the benefits of FC technologies and in order to be able to compare alternative solutions. In relation to distributed generation, FC...... can be used for such analyses. Moreover, the chapter presents the results of evaluating the overall system fuel savings achieved by introducing different FC applications into different energy systems. Natural gas-based and hydrogen-based micro FC-CHP, natural gas local FC-CHP plants for district...... technologies have different strengths and weaknesses in different energy systems, but often they do not have the expected effect. Specific analyses of each individual country must be conducted including scenarios of expansion of e.g. wind power in order to evaluate where and when the best use of FC...

  8. Analysis of the internal heat losses in a thermoelectric generator

    DEFF Research Database (Denmark)

    Bjørk, Rasmus; Christensen, Dennis Valbjørn; Eriksen, Dan

    2014-01-01

    to decrease for increased heat loss. The leg dimensions are varied for all heat losses cases and it is shown that the ideal way to construct a TEG module with minimal heat losses and maximum efficiency is to either use a good insulating material between the legs or evacuate the module completely, and use......A 3D thermoelectric numerical model is used to investigate different internal heat loss mechanisms for a thermoelectric generator with bismuth telluride p- and n-legs. The model considers all thermoelectric effects, temperature dependent material parameters and simultaneous convective, conductive...... and radiative heat losses, including surface to surface radiation. For radiative heat losses it is shown that for the temperatures considered here, surface to ambient radiation is a good approximation of the heat loss. For conductive heat transfer the module efficiency is shown to be comparable to the case...

  9. Next Generation Nuclear Plant Resilient Control System Functional Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Lynne M. Stevens

    2010-07-01

    Control Systems and their associated instrumentation must meet reliability, availability, maintainability, and resiliency criteria in order for high temperature gas-cooled reactors (HTGRs) to be economically competitive. Research, perhaps requiring several years, may be needed to develop control systems to support plant availability and resiliency. This report functionally analyzes the gaps between traditional and resilient control systems as applicable to HTGRs, which includes the Next Generation Nuclear Plant; defines resilient controls; assesses the current state of both traditional and resilient control systems; and documents the functional gaps existing between these two controls approaches as applicable to HTGRs. This report supports the development of an overall strategy for applying resilient controls to HTGRs by showing that control systems with adequate levels of resilience perform at higher levels, respond more quickly to disturbances, increase operational efficiency, and increase public protection.

  10. Topological analysis of a mixing flow generated by natural convection

    Science.gov (United States)

    Contreras, Pablo Sebastián; de la Cruz, Luis Miguel; Ramos, Eduardo

    2016-01-01

    We use topological tools to describe the natural convective motion and the Lagrangian trajectories of a flow generated by stepwise, alternating heating and cooling protocol of opposite vertical walls of a cubic container. The working fluid considered is Newtonian and the system is in presence of the acceleration of gravity but the nonlinear terms are neglected, i.e., we study the piece-wise steady and linear problem. For this convective mixing flow, we identify invariant surfaces formed by the Lagrangian orbits of massless tracers that are topologically equivalent to spherical shells and period-1 lines with elliptic and hyperbolic segments that are located on symmetry planes. We describe the previous features as functions of the Rayleigh number in the range 3 × 104 ≤ Ra ≤ 5 × 105. We show that this system shares properties with other systems with non-toroidal invariant surfaces.

  11. Finite element analysis and performance study of switched reluctance generator

    Science.gov (United States)

    Zhang, Qianhan; Guo, Yingjun; Xu, Qi; Yu, Xiaoying; Guo, Yajie

    2017-03-01

    Analyses a three-phase 12/8 switched reluctance generator (SRG) which is based on its structure and performance principle. The initial size data were calculated by MathCAD, and the simulation model was set up in the ANSOFT software environment with the maximum efficiency and the maximum output power as the main reference parameters. The outer diameter of the stator and the inner diameter of the rotor were parameterized. The static magnetic field distribution, magnetic flux, magnetic energy, torque, inductance characteristics, back electromotive force and phase current waveform of SRG is obtained by analyzing the static magnetic field and the steady state motion of two-dimensional transient magnetic field in ANSOFT environment. Finally, the experimental data of the prototype are compared with the simulation results, which provide a reliable basis for the design and research of SRG wind turbine system.

  12. Generation and Analysis of Hidden Optical-Polarization States

    CERN Document Server

    Singh, Ravi S

    2010-01-01

    A hybrid Optical-Device (Phase-Conjugating Mirror Michelson Interferometer), made up of Phase-conjugate mirror along with ordinary mirror and Polarization Beam-splitter, is formally designed and investigated for the generation of an unusual Optical-Polarization States. This weird yet 'essentially single-mode' optical-polarization state has non-random 'ratio of amplitudes' and non-random 'sum of phases' in orthogonal bases-modes contrary to usual 'truly single-mode' optical-polarization states of which non-random 'ratio of amplitudes' and non-random 'difference of phases' serves as optical-polarization characteristic parameters. Since it is seen not to be characterized by Stokes parameters, one may, therefore, assign the name 'Hidden Optical-Polarization States (HOPS)'. HOPS are characterized by a set of parameters, namely, Hidden Optical-Polarization parameters. Formal experimental schemes are presented to experimentally measure these parameters and, thus, offering characterization of HOPS.

  13. EPCGen2 Pseudorandom Number Generators: Analysis of J3Gen

    Directory of Open Access Journals (Sweden)

    Alberto Peinado

    2014-04-01

    Full Text Available This paper analyzes the cryptographic security of J3Gen, a promising pseudo random number generator for low-cost passive Radio Frequency Identification (RFID tags. Although J3Gen has been shown to fulfill the randomness criteria set by the EPCglobal Gen2 standard and is intended for security applications, we describe here two cryptanalytic attacks that question its security claims: (i a probabilistic attack based on solving linear equation systems; and (ii a deterministic attack based on the decimation of the output sequence. Numerical results, supported by simulations, show that for the specific recommended values of the configurable parameters, a low number of intercepted output bits are enough to break J3Gen. We then make some recommendations that address these issues.

  14. Reliability Analysis and Standardization of Spacecraft Command Generation Processes

    Science.gov (United States)

    Meshkat, Leila; Grenander, Sven; Evensen, Ken

    2011-01-01

    center dot In order to reduce commanding errors that are caused by humans, we create an approach and corresponding artifacts for standardizing the command generation process and conducting risk management during the design and assurance of such processes. center dot The literature review conducted during the standardization process revealed that very few atomic level human activities are associated with even a broad set of missions. center dot Applicable human reliability metrics for performing these atomic level tasks are available. center dot The process for building a "Periodic Table" of Command and Control Functions as well as Probabilistic Risk Assessment (PRA) models is demonstrated. center dot The PRA models are executed using data from human reliability data banks. center dot The Periodic Table is related to the PRA models via Fault Links.

  15. Exergy analysis of a co-generation plant

    Directory of Open Access Journals (Sweden)

    Ferdelji Nenad

    2008-01-01

    Full Text Available Limitations of traditional first-law analysis, based upon thermodynamic performance of process unit coupled with mass and energy balances, are not a serious limitation when dealing with familiar systems. However, when dealing with more uncongenial, complex ones, it provides incomplete insight for such evaluation. These limitations came from the fact that first-law analysis does not indicate the sources or magnitudes of entropy production, which is, by the second law, essential criterion for scaling losses. An evaluation of plant performance will usually require a comparison of the thermodynamic performance of process units with available data from existing plants. Therefore, exergy analysis is more than useful, providing information about magnitudes of losses and their distribution throughout the system as well. Such analysis is very thankful at the level of process units but applied on higher system levels e.g. the comparison of overall plant performance (total system or the performance of subsystems, represents the valuable method for indicating where research resources can be directed to best advantage.

  16. Analyzing Data Generated Through Deliberative Dialogue: Bringing Knowledge Translation Into Qualitative Analysis.

    Science.gov (United States)

    Plamondon, Katrina M; Bottorff, Joan L; Cole, Donald C

    2015-11-01

    Deliberative dialogue (DD) is a knowledge translation strategy that can serve to generate rich data and bridge health research with action. An intriguing alternative to other modes of generating data, the purposeful and evidence-informed conversations characteristic of DD generate data inclusive of collective interpretations. These data are thus dialogic, presenting complex challenges for qualitative analysis. In this article, we discuss the nature of data generated through DD, orienting ourselves toward a theoretically grounded approach to analysis. We offer an integrated framework for analysis, balancing analytical strategies of categorizing and connecting with the use of empathetic and suspicious interpretive lenses. In this framework, data generation and analysis occur in concert, alongside engaging participants and synthesizing evidence. An example of application is provided, demonstrating nuances of the framework. We conclude with reflections on the strengths and limitations of the framework, suggesting how it may be relevant in other qualitative health approaches. © The Author(s) 2015.

  17. The Pain Behaviour Checklist: factor analysis and validation.

    Science.gov (United States)

    Anciano, D

    1986-11-01

    A factor analysis was performed on Philips & Hunter's (1981) Pain Behaviour Checklist for headache sufferers. Three intuitively meaningful factors emerged. All were similarly associated with overall intensity; pain severity does not determine type of pain behaviour. Differences in pain behaviour emerged between migraine and tension headache groups.

  18. 48 CFR 2115.404-71 - Profit analysis factors.

    Science.gov (United States)

    2010-10-01

    ... account in assigning a plus weight. (5) Cost control. This factor is based on the Contractor's previously... TYPES CONTRACTING BY NEGOTIATION Contract Pricing 2115.404-71 Profit analysis factors. (a) The OPM... receive a plus weight, and poor performance or failure to comply with contract terms and conditions a zero...

  19. Analysis on Family Factor in Construction of New Socialist Countryside

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    This paper analyzes the family factor in the construction of new socialist countryside. It is believed that the family plays both the positive role and negative role in new socialist countryside construction. Based on this analysis,it puts forward corresponding countermeasures,including bringing into play the effect of family in promoting production and carrying forward excellent factors of family culture.

  20. Exploratory Tobit factor analysis for multivariate censored data

    NARCIS (Netherlands)

    Kamakura, WA; Wedel, M

    2001-01-01

    We propose Multivariate Tobit models with a factor structure on the covariance matrix. Such models are particularly useful in the exploratory analysis of multivariate censored data and the identification of latent variables from behavioral data. The factor structure provides a parsimonious

  1. Connectivism in Postsecondary Online Courses: An Exploratory Factor Analysis

    Science.gov (United States)

    Hogg, Nanette; Lomicky, Carol S.

    2012-01-01

    This study explores 465 postsecondary students' experiences in online classes through the lens of connectivism. Downes' 4 properties of connectivism (diversity, autonomy, interactivity, and openness) were used as the study design. An exploratory factor analysis was performed. This study found a 4-factor solution. Subjects indicated that autonomy…

  2. Review of Operational Water Consumption and Withdrawal Factors for Electricity Generating Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Macknick, J.; Newmark, R.; Heath, G.; Hallett, K. C.

    2011-03-01

    Various studies have attempted to consolidate published estimates of water use impacts of electricity generating technologies, resulting in a wide range of technologies and values based on different primary sources of literature. The goal of this work is to consolidate the various primary literature estimates of water use during the generation of electricity by conventional and renewable electricity generating technologies in the United States to more completely convey the variability and uncertainty associated with water use in electricity generating technologies.

  3. Confirmatory Factor Analysis of the Career Factors Inventory on a Community College Sample

    Science.gov (United States)

    Simon, Merril A.; Tovar, Esau

    2004-01-01

    A confirmatory factor analysis was conducted using AMOS 4.0 to validate the 21-item Career Factors Inventory on a community college student sample. The multidimensional inventory assesses types and levels of career indecision antecedents. The sample consisted of 512 ethnically diverse freshmen students; 46% were men and 54% were women.…

  4. Power train analysis for the DOE/NASA 100-kW wind turbine generator

    Science.gov (United States)

    Seidel, R. C.; Gold, H.; Wenzel, L. M.

    1978-01-01

    Progress in explaining variations of power experienced in the on-line operation of a 100 kW experimental wind turbine-generator is reported. Data are presented that show the oscillations tend to be characteristic of a wind-driven synchronous generator because of low torsional damping in the power train, resonances of its large structure, and excitation by unsteady and nonuniform wind flow. The report includes dynamic analysis of the drive-train torsion, the generator, passive driveline damping, and active pitch control as well as correlation with experimental recordings. The analysis assumes one machine on an infinite bus with constant generator-field excitation.

  5. Generation and analysis of expressed sequence tags (ESTs) for marker development in yam (Dioscorea alata L.).

    Science.gov (United States)

    Narina, Satya S; Buyyarapu, Ramesh; Kottapalli, Kameswara Rao; Sartie, Alieu M; Ali, Mohamed I; Robert, Asiedu; Hodeba, Mignouna J D; Sayre, Brian L; Scheffler, Brian E

    2011-02-09

    Anthracnose (Colletotrichum gloeosporioides) is a major limiting factor in the production of yam (Dioscorea spp.) worldwide. Availability of high quality sequence information is necessary for designing molecular markers associated with resistance. However, very limited sequence information pertaining to yam is available at public genome databases. Therefore, this collaborative project was developed for genetic improvement and germplasm characterization of yams using molecular markers. The current investigation is focused on studying gene expression, by large scale generation of ESTs, from one susceptible (TDa 95-0310) and two resistant yam genotypes (TDa 87-01091, TDa 95-0328) challenged with the fungus. Total RNA was isolated from young leaves of resistant and susceptible genotypes and cDNA libraries were sequenced using Roche 454 technology. A total of 44,757 EST sequences were generated from the cDNA libraries of the resistant and susceptible genotypes. Greater than 56% of ESTs were annotated using MapMan Mercator tool and Blast2GO search tools. Gene annotations were used to characterize the transcriptome in yam and also perform a differential gene expression analysis between the resistant and susceptible EST datasets. Mining for SSRs in the ESTs revealed 1702 unique sequences containing SSRs and 1705 SSR markers were designed using those sequences. We have developed a comprehensive annotated transcriptome data set in yam to enrich the EST information in public databases. cDNA libraries were constructed from anthracnose fungus challenged leaf tissues for transcriptome characterization, and differential gene expression analysis. Thus, it helped in identifying unique transcripts in each library for disease resistance. These EST resources provide the basis for future microarray development, marker validation, genetic linkage mapping and QTL analysis in Dioscorea species.

  6. Generation and analysis of expressed sequence tags (ESTs for marker development in yam (Dioscorea alata L.

    Directory of Open Access Journals (Sweden)

    Robert Asiedu

    2011-02-01

    Full Text Available Abstract Background Anthracnose (Colletotrichum gloeosporioides is a major limiting factor in the production of yam (Dioscorea spp. worldwide. Availability of high quality sequence information is necessary for designing molecular markers associated with resistance. However, very limited sequence information pertaining to yam is available at public genome databases. Therefore, this collaborative project was developed for genetic improvement and germplasm characterization of yams using molecular markers. The current investigation is focused on studying gene expression, by large scale generation of ESTs, from one susceptible (TDa 95-0310 and two resistant yam genotypes (TDa 87-01091, TDa 95-0328 challenged with the fungus. Total RNA was isolated from young leaves of resistant and susceptible genotypes and cDNA libraries were sequenced using Roche 454 technology. Results A total of 44,757 EST sequences were generated from the cDNA libraries of the resistant and susceptible genotypes. Greater than 56% of ESTs were annotated using MapMan Mercator tool and Blast2GO search tools. Gene annotations were used to characterize the transcriptome in yam and also perform a differential gene expression analysis between the resistant and susceptible EST datasets. Mining for SSRs in the ESTs revealed 1702 unique sequences containing SSRs and 1705 SSR markers were designed using those sequences. Conclusion We have developed a comprehensive annotated transcriptome data set in yam to enrich the EST information in public databases. cDNA libraries were constructed from anthracnose fungus challenged leaf tissues for transcriptome characterization, and differential gene expression analysis. Thus, it helped in identifying unique transcripts in each library for disease resistance. These EST resources provide the basis for future microarray development, marker validation, genetic linkage mapping and QTL analysis in Dioscorea species.

  7. Generated spiral bevel gears: Optimal machine-tool settings and tooth contact analysis

    Science.gov (United States)

    Litvin, F. L.; Tsung, W. J.; Coy, J. J.; Heine, C.

    1985-01-01

    Geometry and kinematic errors were studied for Gleason generated spiral bevel gears. A new method was devised for choosing optimal machine settings. These settings provide zero kinematic errors and an improved bearing contact. The kinematic errors are a major source of noise and vibration in spiral bevel gears. The improved bearing contact gives improved conditions for lubrication. A computer program for tooth contact analysis was developed, and thereby the new generation process was confirmed. The new process is governed by the requirement that during the generation process there is directional constancy of the common normal of the contacting surfaces for generator and generated surfaces of pinion and gear.

  8. Generated spiral bevel gears - Optimal machine-tool settings and tooth contact analysis

    Science.gov (United States)

    Litvin, F. L.; Tsung, W.-J.; Coy, J. J.; Heine, C.

    1985-01-01

    Geometry and kinematic errors were studied for Gleason generated spiral bevel gears. A new method was devised for choosing optimal machine settings. These settings provide zero kinematic errors and an improved bearing contact. The kinematic errors are a major source of noise and vibration in spiral bevel gears. The improved bearing contact gives improved conditions for lubrication. A computer program for tooth contact analysis was developed, and thereby the new generation process was confirmed. The new process is governed by the requirement that during the generation process there is directional constancy of the common normal of the contacting surfaces for generator and generated surfaces of pinion and gear.

  9. Second Law Analysis of the Optimal Fin by Minimum Entropy Generation

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Based on the entropy generation concept of thermodynamics, this paper established a general theoretical model for the analysis of entropy generation to optimize fms, in which the minimum entropy generation was selected as the object to be studied. The irreversibility due to heat transfer and friction was taken into account so that the minimum entropygeneration number has been analyzed with respect to second law of thermodynamics in the forced cross-flow. The optimum dimensions of cylinder pins were discussed. It's found that the minimum entropy generation number depends on parameters related to the fluid and fin physical parameters. Variations of the minimum entropy generation number with different parameters were analyzed.

  10. Analysis of Steam Generators Corrosion Products from Slovak NPP Bohunice

    Directory of Open Access Journals (Sweden)

    Jarmila Degmová

    2012-01-01

    Full Text Available One of the main goals of the nuclear industry is to increase the nuclear safety and reliability of nuclear power plants (NPPs. As the steam generator (SG is the most corrosion sensitive component of NPPs, it is important to analyze the corrosion process and optimize its construction materials to avoid damages like corrosion cracking. For this purpose two different kinds of SGs and its feed water distributing systems from the NPP Jaslovske Bohunice were studied by nondestructive Mössbauer spectroscopy. The samples were scraped from the surface and analyzed in transmission geometry. Magnetite and hematite were found to be the main components in the corrosion layers of both SGs. Dependant of the material the SG consisted of, and the location in the system where the samples were taken, the ratios between magnetite and hematite and the paramagnetic components were different. The obtained results can be used to improve corrosion safety of the VVER-440 secondary circuit as well as to optimize its water chemistry regime.

  11. Análise dos fatores motivacionais das gerações baby boomers, X, Y e Z e as suas expectativas sobre carreira profissional = Analysis of motivational factors of baby boomers, X, Y and Z generations and their expectations about professional career

    Directory of Open Access Journals (Sweden)

    Carolina Aude Fantini

    2015-07-01

    behaviors, values and needs. These needs impacts in the motivation and in the perspectives that each one has about the personal and professional future. The goal of this project is to understand motivational factors that influence the employees of each generation and check what their career expectations are. For this, the methodology used was field research with the elaboration of a questionnaire that contains seventeen closed multiple-choice questions and one question for comments. The questionnaire was delivered personally, or in few cases sent by e-mail to one hundred seventy-eight workers of different age groups of some companies in Bauru/SP. The results presented on the expectation of the career were that the majority of Baby boomers, X and Y generations want to build a solid career in the same company, opting for stability and fidelity of your jobs. The generation Z prefers the career without boundaries motivated by factors such as flexibility, autonomy and quality of life. Furthermore, the results point that the majority of employees of all generations are satisfied with their current jobs and they have been thinking about the future planning their careers. Another discussion of the research showed that the most relevant motivational factors for the generations were financial security, quality of life and flexibility at work.

  12. Conditioning Analysis of Incomplete Cholesky Factorizations with Orthogonal Dropping

    Energy Technology Data Exchange (ETDEWEB)

    Napov, Artem [Free Univ. of Brussels (Belgium)

    2013-08-01

    The analysis of preconditioners based on incomplete Cholesky factorization in which the neglected (dropped) components are orthogonal to the approximations being kept is presented. General estimate for the condition number of the preconditioned system is given which only depends on the accuracy of individual approximations. The estimate is further improved if, for instance, only the newly computed rows of the factor are modified during each approximation step. In this latter case it is further shown to be sharp. The analysis is illustrated with some existing factorizations in the context of discretized elliptic partial differential equations.

  13. Conditioning Analysis of Incomplete Cholesky Factorizations with Orthogonal Dropping

    Energy Technology Data Exchange (ETDEWEB)

    Napov, Artem [Free Univ. of Brussels (Belgium)

    2013-08-01

    The analysis of preconditioners based on incomplete Cholesky factorization in which the neglected (dropped) components are orthogonal to the approximations being kept is presented. General estimate for the condition number of the preconditioned system is given which only depends on the accuracy of individual approximations. The estimate is further improved if, for instance, only the newly computed rows of the factor are modified during each approximation step. In this latter case it is further shown to be sharp. The analysis is illustrated with some existing factorizations in the context of discretized elliptic partial differential equations.

  14. Risk Factors Analysis on Traumatic Brain Injury Prognosis

    Institute of Scientific and Technical Information of China (English)

    Xiao-dong Qu; Resha Shrestha; Mao-de Wang

    2011-01-01

    To investigate the independent risk factors of traumatic brain injury (TBI) prognosis.Methods A retrospective analysis was performed in 885 hospitalized TEl patients from January 1,2003 to January 1, 2010 in the First Affiliated Hospital of Medical College of Xi' an Jiaotong University. Single-factor and logistic regression analysis were conducted to evaluate the association of different variables with TBI outcome.Results The single-factor analysis revealed significant association between several variables and TEl outcome, including age (P=0.044 for the age group 40-60, P<0.001 for the age group ≥60), complications (P<0.001), cerebrospinal fluid leakage (P<0.001), Glasgow Coma Scale (GCS) (P<0.001), pupillary light reflex (P<0.001), shock (P<0.001), associated extra-cranial lesions (P=0.01), subdural hematoma (P<0.001), cerebral contusion (P<0.001), diffuse axonal injury (P<0.001), and subarachnoid hemorrhage (P<0.001), suggesting the influence of those factors on the prognosis of TBI. Furthermore, logistic regression analysis identified age, GCS score, pupillary light reflex, subdural hematoma, and subarachnoid hemorrhage as independent risk factors of TEl prognosis.Conclusion Age, GCS score, papillary light reflex, subdural hematoma, and subarachnoid hemorrhage may be risk factors influencing the prognosis of TEl. Paying attention to those factors might improve the outcome of TBI in clinical treatment.

  15. Analysis of the financial factors governing the profitability of lunar helium-3

    Science.gov (United States)

    Kulcinski, G. L.; Thompson, H.; Ott, S.

    1989-01-01

    Financial factors influencing the profitability of the mining and utilization of lunar helium-3 are examined. The analysis addressed the following questions: (1) which financial factors have the greatest leverage on the profitability of He-3; (2) over what range can these factors be varied to keep the He-3 option profitable; and (3) what ultimate effect could this energy source have on the price of electricity for U.S. consumers. Two complementary methods of analysis were used in the assessment: rate of return on incremental investment required and reduction revenue requirements (total cost to customers) achieved. Some of the factors addressed include energy demand, power generation costs with and without fusion, profitability for D-He(3) fusion, annual capital and operating costs, launch mass and costs, He-3 price, and government funding. Specific conclusions are made with respect to each of the companies considered: utilities, lunar mining company, and integrated energy company.

  16. Analysis on total factor productivity of Chinese provincial economy

    Institute of Scientific and Technical Information of China (English)

    GUO Qingwang; ZHAO Zhiyun; JIA Junxue

    2006-01-01

    This paper applies the nonparametric DEA-Malmquist index approach to estimate total factor productivity growth,efficiency change and the rate of technological progress from 1979 to 2003.This is done to conduct analysis on the total factor productivity of China's provincial economy.Analysis on the evolution of distribution dynamics of relative labor productivity,relative total factor productivity,relative efficiency and relative technological progress is done by using kernel density estimation flor the period from 1979 to 2003 in 29 provinces of China.Our analysis indicates that disparities of provincial economic growth are large and have been increasing owing to the relatively large and increasing disparities of total factor productivity growth especially the rate of technological progress.

  17. Analysis of related risk factors for pancreatic fistula after pancreaticoduodenectomy

    Institute of Scientific and Technical Information of China (English)

    Qi-Song Yu; He-Chao Huang; Feng Ding; Xin-Bo Wang

    2016-01-01

    Objective:To explore the related risk factors for pancreatic fistula after pancreaticoduodenectomy to provide a theoretical evidence for effectively preventing the occurrence of pancreatic fistula.Methods:A total of 100 patients who were admitted in our hospital from January, 2012 to January, 2015 and had performed pancreaticoduodenectomy were included in the study. The related risk factors for developing pancreatic fistula were collected for single factor and Logistic multi-factor analysis.Results:Among the included patients, 16 had pancreatic fistula, and the total occurrence rate was 16% (16/100). The single-factor analysis showed that the upper abdominal operation history, preoperative bilirubin, pancreatic texture, pancreatic duct diameter, intraoperative amount of bleeding, postoperative hemoglobin, and application of somatostatin after operation were the risk factors for developing pancreatic fistula (P<0.05). The multi-factor analysis showed that the upper abdominal operation history, the soft pancreatic texture, small pancreatic duct diameter, and low postoperative hemoglobin were the dependent risk factors for developing pancreatic fistula (OR=4.162, 6.104, 5.613, 4.034,P<0.05).Conclusions:The occurrence of pancreatic fistula after pancreaticoduodenectomy is closely associated with the upper abdominal operation history, the soft pancreatic texture, small pancreatic duct diameter, and low postoperative hemoglobin; therefore, effective measures should be taken to reduce the occurrence of pancreatic fistula according to the patients’own conditions.

  18. Environmental Performance in Countries Worldwide: Determinant Factors and Multivariate Analysis

    Directory of Open Access Journals (Sweden)

    Isabel Gallego-Alvarez

    2014-11-01

    Full Text Available The aim of this study is to analyze the environmental performance of countries and the variables that can influence it. At the same time, we performed a multivariate analysis using the HJ-biplot, an exploratory method that looks for hidden patterns in the data, obtained from the usual singular value decomposition (SVD of the data matrix, to contextualize the countries grouped by geographical areas and the variables relating to environmental indicators included in the environmental performance index. The sample used comprises 149 countries of different geographic areas. The findings obtained from the empirical analysis emphasize that socioeconomic factors, such as economic wealth and education, as well as institutional factors represented by the style of public administration, in particular control of corruption, are determinant factors of environmental performance in the countries analyzed. In contrast, no effect on environmental performance was found for factors relating to the internal characteristics of a country or political factors.

  19. Factors Associated with College Students' Intentions to Vaccinate Their Daughters Against HPV: Protecting the Next Generation.

    Science.gov (United States)

    Wilson, Kelly L; White, Alice; Rosen, Brittany L; Chiappone, Alethea; Pulczinski, Jairus C; Ory, Marcia G; Smith, Matthew Lee

    2016-10-01

    Human papillomavirus (HPV) is a contemporary public health concern because of its association with cervical cancer. Despite evidence about HPV vaccination benefits, debate surrounds whether or not to vaccinate American youth. While no nationwide mandate exists, understanding the behaviors and intentions of future parents may provide insight about our ability to protect the next generation of school-aged youth. The purposes of this study were to examine factors associated with unmarried college students' intentions to: (1) vaccinate their daughters against HPV and (2) give their daughters the choice about whether or not to be vaccinated. Data were analyzed from 1606 college students aged 18-26 using an internet-delivered questionnaire. Two binary logistic regression analyses were performed identifying predictor variables associated with participants' intentions when having daughters in the future to vaccinate them against HPV and whether or not they would let their daughters decide to get the vaccination. Relative to those who did not intend to vaccinate their daughters against HPV, participants who were female (OR 1.55, P = 0.018), sexually active (OR 1.62, P = 0.001), diagnosed with HPV (OR 2.64, P HPV vaccine to be safe (OR 1.19, P HPV vaccination mandates for school-aged youth (OR 2.58, P vaccinating their daughters against HPV. Participants who were sexually active (OR 1.45, P = 0.002) and perceived the HPV vaccine to be safe (OR 1.05, P = 0.012) were more likely to report they would allow their daughters to choose whether to be vaccinated against HPV. Until HPV vaccination mandates are enacted, parental support of vaccines are among the most effective way of increasing vaccine uptake. Identifying HPV vaccination support among future parents has potential to inform parent vaccination education programs related and advocacy for HPV vaccination policies.

  20. Computational analysis of the effects of reduced temperature on thrombin generation: the contributions of hypothermia to coagulopathy.

    Science.gov (United States)

    Mitrophanov, Alexander Y; Rosendaal, Frits R; Reifman, Jaques

    2013-09-01

    Hypothermia, which can result from tissue hypoperfusion, body exposure, and transfusion of cold resuscitation fluids, is a major factor contributing to coagulopathy of trauma and surgery. Despite considerable efforts, the mechanisms of hypothermia-induced blood coagulation impairment have not been fully understood. We introduce a kinetic modeling approach to investigate the effects of hypothermia on thrombin generation. We extended a validated computational model to predict and analyze the impact of low temperatures (with or without concomitant blood dilution) on thrombin generation and its quantitative parameters. The computational model reflects the existing knowledge about the mechanistic details of thrombin generation biochemistry. We performed the analysis for an "average" subject, as well as for 472 subjects in the control group of the Leiden Thrombophilia Study. We computed and analyzed thousands of kinetic curves characterizing the generation of thrombin and the formation of the thrombin-antithrombin complex (TAT). In all simulations, hypothermia in the temperature interval 31°C to 36°C progressively slowed down thrombin generation, as reflected by clotting time, thrombin peak time, and prothrombin time, which increased in all subjects (P computational strategy that can be used to simulate the effects of changing temperature on the kinetics of biochemical systems and applied this strategy to analyze the effects of hypothermia on thrombin generation. We found that thrombin generation can be noticeably impaired in subjects with different blood plasma composition even in moderate hypothermia. Our work provides mechanistic support to the notion that thrombin generation impairment may be a key factor in coagulopathy induced by hypothermia and complicated by blood plasma dilution.

  1. Dynamic Analysis of Nuclear Waste Generation Based on Nuclear Fuel Cycle Transition Scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, S. R. [University of Science and Technology, Daejeon (Korea, Republic of); Ko, W. I. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2015-10-15

    According to the recommendations submitted by the Public Engagement Commission on Spent Nuclear Fuel Management (PECOS), the government was advised to pick the site for an underground laboratory and interim storage facilities before the end of 2020 followed by the related research for permanent and underground disposal of spent fuel after 10 years. In the middle of the main issues, the factors of environmentally friendly and safe way to handle nuclear waste are inextricable from nuclear power generating nation to ensure the sustainability of nuclear power. For this purposes, the closed nuclear fuel cycle has been developed regarding deep geological disposal, pyroprocessing, and burner type sodium-cooled fast reactors (SFRs) in Korea. Among two methods of an equilibrium model and a dynamic model generally used for screening nuclear fuel cycle system, the dynamic model is more appropriate to envisage country-specific environment with the transition phase in the long term and significant to estimate meaningful impacts based on the timedependent behavior of harmful wastes. This study aims at analyzing the spent nuclear fuel generation based on the long-term nuclear fuel cycle transition scenarios considered at up-to-date country specific conditions and comparing long term advantages of the developed nuclear fuel cycle option between once-through cycle and Pyro-SFR cycle. In this study, a dynamic analysis was carried out to estimate the long-term projection of nuclear electricity generation, installed capacity, spent nuclear fuel arising in different fuel cycle scenarios based on the up-to-date national energy plans.

  2. Entropy Generation Analysis for a CNT Suspension Nanofluid in Plumb Ducts with Peristalsis

    OpenAIRE

    Noreen Sher Akbar

    2015-01-01

    The purpose of the current investigation was to discuss the entropy generation analysis for a carbon nanotube (CNT) suspension nanofluid in a plumb duct with peristalsis. The entropy generation number due to heat transfer and fluid friction is formulated. The velocity and temperature distributions across the tube are presented along with pressure attributes. Exact analytical solution for velocity and temperature profile are obtained. It is found that the entropy generation number attains high...

  3. ANALYSIS OF RISK FACTORS IN 3901 PATIENTS WITH STROKE

    Institute of Scientific and Technical Information of China (English)

    Xin-Feng Liu; Guy van Melle; Julien Bogousslavsky

    2005-01-01

    Objective To estimate the frequency of various risk factors for overall stroke and to identify risk factors for cerebral infarction (CI) versus intracerebral hemorrhage (ICH) in a large hospital-based stroke registry.Methods Data from a total of 3901 patients, consisting of 3525 patients with CI and 376 patients with ICH were prospectively coded and entered into a computerized data bank.Results Hypertension and smoking were the most prominent factors affecting overall stroke followed by mild internal carotid artery stenosis (< 50%), hypercholesterolemia, transient ischemic attacks (TIAs), diabetes mellitus, and cardiac ischemia. Univariate analysis showed that factors in male significantly associated with CI versus ICH were old age, a family history of stroke, and intermittent claudication; whereas in female the factors were oral contraception and migraine. By multivariate analysis, in all patients, the factors significantly associated with CI as opposed to ICH were smoking, hypercholesterolemia, migraine, TIAs, atrial fibrillation, structural heart disease, and arterial disease. Hypertension was the only significant factor related with ICH versus CI.Conclusions The factors for ischemic and hemorrhagic stroke are not exactly the same. Cardiac and arterial disease are the most powerful factors associated with CI rather than ICH.

  4. Analysis of effect factors-based stochastic network planning model

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    Looking at all the indeterminate factors as a whole and regarding activity durations as independent random variables,the traditional stochastic network planning models ignore the inevitable relationship and dependence among activity durations when more than one activity is possibly affected by the same indeterminate factors.On this basis of analysis of indeterminate effect factors of durations,the effect factors-based stochastic network planning (EFBSNP) model is proposed,which emphasizes on the effects of not only logistic and organizational relationships,but also the dependent relationships,due to indeterminate factors among activity durations on the project period.By virtue of indeterminate factor analysis the model extracts and describes the quantitatively indeterminate effect factors,and then takes into account the indeterminate factors effect schedule by using the Monte Carlo simulation technique.The method is flexible enough to deal with effect factors and is coincident with practice.A software has been developed to simplify the model-based calculation,in VisualStudio.NET language.Finally,a case study is included to demonstrate the applicability of the proposed model and comparison is made with some advantages over the existing models.

  5. Stability Analysis for Isolated AC Microgrids Based on PV-Active Generators

    DEFF Research Database (Denmark)

    Aldana, Nelson Leonardo Diaz; Coelho, Ernane A. A.; Quintero, Juan Carlos Vasquez;

    2015-01-01

    The current trend in isolated microgrids is oriented to distributed renewable energy generators, such as photovoltaic (PV) generators and their corresponding distributed energy storage systems (ESS) as an unit denoted as active generator (PV+ESS). In an isolated microgrid, every distributed...... for all the distributed generators. In particular, ESS’s based on batteries require at least two different mode of charge. As consequence, the topological operation mode of the microgrid is affected by the changes of the operation mode of each distributed generator. Typically, droop control loops are used...... for interconnecting several different distributed generators in parallel to a common bus, whose parameters determine the stability and damping of the microgrid operation. In this paper, a small-signal stability analysis is applied to an isolated AC microgrid composed of (PV+ESS) active generators, regarding three...

  6. Entropy generation analysis in a 180-degree return bend pipe using nanofluid

    Science.gov (United States)

    Mukherjee, Arnab; Rout, Swetapadma; Barik, Ashok K.

    2017-07-01

    Heat transfer and entropy generation analysis for 180-degree return bend has been carried out numerically using Al2O3-water nanofluid. The governing differential equations for mass, momentum and energy are solved in a staggered grid arrangement employing finite volume technique. A constant temperature boundary condition has been applied to the bend portion of the pipe. Reynolds number based on the hydraulic diameter of the duct and nanofluid volume fraction have varies from 200 to 1800 and 0 to 5%, respectively. Both the thermal and frictional entropy generations are quantified to access the total entropy generation. The frictional entropy generation is found to be lower than the thermal entropy generation. The ratio of the thermal and total entropy generation rates has been presented in term of Bejan number. Bejan number at low Reynolds number has been close to 1 due to the dominance of the thermal entropy generation.

  7. A neuron-benign microfluidic gradient generator for studying the response of mammalian neurons towards axon guidance factors.

    Science.gov (United States)

    Bhattacharjee, Nirveek; Li, Nianzhen; Keenan, Thomas M; Folch, Albert

    2010-11-01

    Investigation of biochemical cues in isolation or in combinations in cell culture systems is crucial for unraveling the mechanisms that govern neural development and repair. The most widely used experimental paradigms that elicit axon guidance in vitro utilize as the source of the gradient a pulsatile pipette, transfected cells, or a loaded gel, producing time-varying gradients of poor reproducibility which are not well suited for studying slow-growing mammalian cells. Although microfluidic device design have allowed for generating stable, complex gradients of diffusible molecules, the flow-induced shear forces in a microchannel has made it impossible to maintain viable mammalian neuronal cultures for sufficiently long times. In this paper, we describe axonal responses of mouse cortical neurons in a "neuron-benign" gradient-generator device based on an open chamber that can establish highly stable gradients of diffusible molecules for at least 6 h with negligible shear stress, and also allows the neurons to thrive for at least 2 weeks. Except for the period when the gradient is on, the cells in the gradient are under the same conditions as the cells on the control surfaces, which ensure a consistent set of micro-environmental variables. The gradient stability and uniformity over the cell culture surface achieved by the device, together with our software platform for acquiring, post-processing and quantitatively analyzing the large number of images allowed us to extract valuable information even from small datasets. We report a directed response of primary mammalian neurons (from E14 embryonic mice cortex) to a diffusible gradient of netrin in vitro. We infer from our studies that a large majority (∼73%) of the neurons that extend axons during the gradient application grow towards the netrin source, and our data analysis also indicates that netrin acts as a growth factor for this same population of neurons.

  8. Analysis and discussion on anti-thunder scheme of wind power generation system

    Science.gov (United States)

    Sun, Shuguang

    2017-01-01

    Anti-thunder scheme of wind power generation system is discussed in this paper. Through the research and analysis on the harm of the thunder, division of lightning protection zone and lightning protection measures are put forward, which has a certain practical significance on the design and application of wind power generation system.

  9. Business analysis of generation considering environmental opportunities; Analise de negocios de geracao considerando oportunidades ambientais

    Energy Technology Data Exchange (ETDEWEB)

    Cyrillo, Ivo Ordonha [Universidade de Sao Paulo (ENERQ/USP), SP (Brazil). Centro de Estudos em Regulacao e Qualidade de Energia; Pelegrini, Marcelo A.; Gemignani, Matheus M.F.

    2008-07-01

    The project 'Business's Power Generation Evaluation Considering Environmental Opportunities' is about developing a methodology to analyze feasibility of new power generation factory from the point of view of the investor, examining the technical, economic-financial, risk, regulatory, social and environmental aspects. The opportunities arising from Kyoto Protocol were added in feasibility's analysis. (author)

  10. Analysis of Turkish High School Chemistry Textbooks and Teacher-Generated Questions about Gas Laws

    Science.gov (United States)

    Nakiboglu, Canan; Yildirir, H.

    2011-01-01

    This study presents the results of an analysis of high school chemistry textbooks and teacher-generated questions about gas laws. The materials that were analyzed consisted of 456 questions about gas laws found in seven grade 10 chemistry textbooks and 264 teacher-generated examination questions prepared by seven chemistry teachers from three…

  11. Incorporation of wind generation to the Mexican power grid: Steady state analysis

    Energy Technology Data Exchange (ETDEWEB)

    Tovar, J.H.; Guardado, J.L.; Cisneros, F. [Inst. Tecnologico de Morelia (Mexico); Cadenas, R.; Lopez, S. [Comision Federal de Electricidad, Morelia (Mexico)

    1997-09-01

    This paper describes a steady state analysis related with the incorporation of large amounts of eolic generation into the Mexican power system. An equivalent node is used to represent individual eolic generators in the wind farm. Possible overloads, losses, voltage and reactive profiles and estimated severe contingencies are analyzed. Finally, the conclusions of this study are presented.

  12. Design, Prototyping, and Analysis of a Novel Modular Permanent Magnet Transverse Flux Disk Generator

    DEFF Research Database (Denmark)

    Hosseini, Seyedmohsen; Moghani, Javad Shokrollahi; Ershad, Nima Farrokhzad

    2011-01-01

    This paper presents the design, prototyping, and analysis of a novel modular transverse flux permanent magnet disk generator. The disk-shaped structure simplifies the construction procedure by using laminated steel sheets. To reduce output harmonics, the excitation of the generator is done......, a prototype has been constructed and tested. The experimental results are in good agreement with simulation results....

  13. Bayesian Switching Factor Analysis for Estimating Time-varying Functional Connectivity in fMRI.

    Science.gov (United States)

    Taghia, Jalil; Ryali, Srikanth; Chen, Tianwen; Supekar, Kaustubh; Cai, Weidong; Menon, Vinod

    2017-03-03

    There is growing interest in understanding the dynamical properties of functional interactions between distributed brain regions. However, robust estimation of temporal dynamics from functional magnetic resonance imaging (fMRI) data remains challenging due to limitations in extant multivariate methods for modeling time-varying functional interactions between multiple brain areas. Here, we develop a Bayesian generative model for fMRI time-series within the framework of hidden Markov models (HMMs). The model is a dynamic variant of the static factor analysis model (Ghahramani and Beal, 2000). We refer to this model as Bayesian switching factor analysis (BSFA) as it integrates factor analysis into a generative HMM in a unified Bayesian framework. In BSFA, brain dynamic functional networks are represented by latent states which are learnt from the data. Crucially, BSFA is a generative model which estimates the temporal evolution of brain states and transition probabilities between states as a function of time. An attractive feature of BSFA is the automatic determination of the number of latent states via Bayesian model selection arising from penalization of excessively complex models. Key features of BSFA are validated using extensive simulations on carefully designed synthetic data. We further validate BSFA using fingerprint analysis of multisession resting-state fMRI data from the Human Connectome Project (HCP). Our results show that modeling temporal dependencies in the generative model of BSFA results in improved fingerprinting of individual participants. Finally, we apply BSFA to elucidate the dynamic functional organization of the salience, central-executive, and default mode networks-three core neurocognitive systems with central role in cognitive and affective information processing (Menon, 2011). Across two HCP sessions, we demonstrate a high level of dynamic interactions between these networks and determine that the salience network has the highest temporal

  14. The Risk of Venous Thromboembolism with Different Generation of Oral Contraceptives; a Systematic Review and Meta-Analysis

    Directory of Open Access Journals (Sweden)

    Alireza Baratloo

    2014-03-01

    Full Text Available Introduction: Oral contraceptives (OCs are considered as one of the most common risk factor of venous thromboembolism (VTE in child bearing age. Some of the recent researches indicate that the odds of VTE may be even higher with newer generations of OCs. The present meta-analysis was designed to evaluate the effect of different generation of OCs on the occurrence of VTE. Methods: Two researchers independently ran a thorough search in Pubmed, ISI Web of Science, EMBASE, CINAHL and Scopus databases regarding study keywords including thromboembolic event, thromboembolism, embolism, thromboembolic, thrombotic and thrombosis, combined with oral contraceptive. The outcomes were the incidence of diagnosed thromboembolism, such as deep vein thrombosis, pulmonary embolism and cerebral venous thrombosis. Based on the heterogeneity of the studies, random effect model was used and pooled odds ratio was reported. Results: Three cohort and 17 case-control studies with 13,265,228 subjects were entered into meta-analysis. Analysis showed that the odds of VTE in women taking OCs are more than three-fold (OR=3.13; 95% CI: 2.61-3.65. The risk of VTE in women taking first-, second- and third-generation OCs are 3.5 fold (OR=3.48; 95% CI: 2.01-4.94, 3 fold (OR=3.08; 95% CI: 2.43-3.74 and 4.3 fold (OR=4.35; CI: 3.69‒5.01, respectively. Conclusion: It seems that the risk of VTE is not same between different generations of OCs, so that third-generation has highest risk. Taking second and third-generation OCs increases the risk of VTE up to 3 and 4.3 fold, respectively. The researchers of the present study suggest that more clinical trials be designed in relation to the effect of newer generations of OCs in different communities. 

  15. A receptor model for urban aerosols based on oblique factor analysis

    DEFF Research Database (Denmark)

    Keiding, Kristian; Sørensen, Morten S.; Pind, Niels

    1987-01-01

    A procedure is outlined for the construction of receptor models of urban aerosols, based on factor analysis. The advantage of the procedure is that the covariation of source impacts is included in the construction of the models. The results are compared with results obtained by other receptor-modelling...... procedures. It was found that procedures based on correlating sources were physically sound as well as in mutual agreement. Procedures based on non-correlating sources were found to generate physically obscure models....

  16. The Modeling and Simulation of Thermal Analysis at Hydro Generator Stator Winding Insulation

    Directory of Open Access Journals (Sweden)

    Mihaela Raduca

    2006-10-01

    Full Text Available This paper presents the modelling and simulation of thermal analysis at hydro generator stator winding. The winding stator is supplied at high voltage of 11 kV for high power hydro generator. To present the thermal analysis for stator winding is presented at supply of coil by 11 kV, when coil is heat and thermal transfer in insulation at ambient temperature.

  17. Factors affecting the potential of direct load control for non-generating utilities. Final report. [Distribution and wholesale power supply interaction

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-04-01

    Several alternatives are available for achieving load management, including direct or voluntary control of customer loads, customer or utility energy storage systems for diurnal load shifting, and expanded interconnection and operation of electric power systems. All of these alternatives are available to the fully integrated (generating, transmitting and distributing) electric utility and the analysis of their effects encompasses the power supply and delivery system. However, the costs and benefits of the alternatives to the fully integrated electric utility are perhaps not so obvious. Therefore, by considering a non-generating utility, this analysis focuses upon the distribution system and wholesale power supply interaction as a step toward an analysis including the power supply and delivery system. This report develops an analysis procedure and discusses some of the relevant factors to be consdered in the application of direct load control for a non-generating utility system. The analysis concentrates on the distribution system only to determine the effect of rates and payback as a result of direct load control. Thus, the study is responsive to the specific needs of the non-generating utility. This analysis of direct load control encompasses the determination of those loads amenable to control, the selection of a suitable one-way communications system to rend control and the estimation of expected benefits and costs. The complementary functions to the application of direct load control such as automatic meter reading via the addition of a bi-directional communications system and voltage control are not included in the analysis but are detailed for future consideration.

  18. Analysis of pulsed eddy current data using regression models for steam generator tube support structure inspection

    Science.gov (United States)

    Buck, J. A.; Underhill, P. R.; Morelli, J.; Krause, T. W.

    2016-02-01

    Nuclear steam generators (SGs) are a critical component for ensuring safe and efficient operation of a reactor. Life management strategies are implemented in which SG tubes are regularly inspected by conventional eddy current testing (ECT) and ultrasonic testing (UT) technologies to size flaws, and safe operating life of SGs is predicted based on growth models. ECT, the more commonly used technique, due to the rapidity with which full SG tube wall inspection can be performed, is challenged when inspecting ferromagnetic support structure materials in the presence of magnetite sludge and multiple overlapping degradation modes. In this work, an emerging inspection method, pulsed eddy current (PEC), is being investigated to address some of these particular inspection conditions. Time-domain signals were collected by an 8 coil array PEC probe in which ferromagnetic drilled support hole diameter, depth of rectangular tube frets and 2D tube off-centering were varied. Data sets were analyzed with a modified principal components analysis (MPCA) to extract dominant signal features. Multiple linear regression models were applied to MPCA scores to size hole diameter as well as size rectangular outer diameter tube frets. Models were improved through exploratory factor analysis, which was applied to MPCA scores to refine selection for regression models inputs by removing nonessential information.

  19. Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia.

    Directory of Open Access Journals (Sweden)

    Jingping Ge

    Full Text Available Diamond Blackfan Anemia (DBA is an inherited bone marrow failure syndrome with clinical features of red cell aplasia and variable developmental abnormalities. Most affected patients have heterozygous loss of function mutations in ribosomal protein genes but the pathogenic mechanism is still unknown. We generated induced pluripotent stem cells from DBA patients carrying RPS19 or RPL5 mutations. Transcriptome analysis revealed the striking dysregulation of the transforming growth factor β (TGFβ signaling pathway in DBA lines. Expression of TGFβ target genes, such as TGFBI, BAMBI, COL3A1 and SERPINE1 was significantly increased in the DBA iPSCs. We quantified intermediates in canonical and non-canonical TGFβ pathways and observed a significant increase in the levels of the non-canonical pathway mediator p-JNK in the DBA iPSCs. Moreover, when the mutant cells were corrected by ectopic expression of WT RPS19 or RPL5, levels of p-JNK returned to normal. Surprisingly, nuclear levels of SMAD4, a mediator of canonical TGFβ signaling, were decreased in DBA cells due to increased proteolytic turnover. We also observed the up-regulation of TGFβ1R, TGFβ2, CDKN1A and SERPINE1 mRNA, and the significant decrease of GATA1 mRNA in the primitive multilineage progenitors. In summary our observations identify for the first time a dysregulation of the TGFβ pathway in the pathobiology of DBA.

  20. Biological risk factors for suicidal behaviors: a meta-analysis.

    Science.gov (United States)

    Chang, B P; Franklin, J C; Ribeiro, J D; Fox, K R; Bentley, K H; Kleiman, E M; Nock, M K

    2016-09-13

    Prior studies have proposed a wide range of potential biological risk factors for future suicidal behaviors. Although strong evidence exists for biological correlates of suicidal behaviors, it remains unclear if these correlates are also risk factors for suicidal behaviors. We performed a meta-analysis to integrate the existing literature on biological risk factors for suicidal behaviors and to determine their statistical significance. We conducted a systematic search of PubMed, PsycInfo and Google Scholar for studies that used a biological factor to predict either suicide attempt or death by suicide. Inclusion criteria included studies with at least one longitudinal analysis using a biological factor to predict either of these outcomes in any population through 2015. From an initial screen of 2541 studies we identified 94 cases. Random effects models were used for both meta-analyses and meta-regression. The combined effect of biological factors produced statistically significant but relatively weak prediction of suicide attempts (weighted mean odds ratio (wOR)=1.41; CI: 1.09-1.81) and suicide death (wOR=1.28; CI: 1.13-1.45). After accounting for publication bias, prediction was nonsignificant for both suicide attempts and suicide death. Only two factors remained significant after accounting for publication bias-cytokines (wOR=2.87; CI: 1.40-5.93) and low levels of fish oil nutrients (wOR=1.09; CI: 1.01-1.19). Our meta-analysis revealed that currently known biological factors are weak predictors of future suicidal behaviors. This conclusion should be interpreted within the context of the limitations of the existing literature, including long follow-up intervals and a lack of tests of interactions with other risk factors. Future studies addressing these limitations may more effectively test for potential biological risk factors.

  1. Expression of Intracellular Domain of Epidermal Growth Factor Receptor and Generation of Its Monoclonal Antibody

    Institute of Scientific and Technical Information of China (English)

    Ying Lin; Zhiduo Liu; Jianmin Jiang; Ziqing Jiang; Yongyong Ji; Bing Sun

    2004-01-01

    To prepare monoclonal antibody specific to epidermal growth factor receptor (EGFR) intracellular domain, its gene was amplified from total RNA of A431 cell by RT-PCR. Then the gene was cloned into prokaryotic vector pET30a(+). The recombinant plasmid was transformed into E. Coli BL21 (DE3) strain for protein expression.Recombinant protein was induced with IPTG and purified using Ni2+-NTA agarose. Then the anti-EGFR monoclonal antibody (nAb) was prepared with classical hybridoma technique. Positive clones were selected using indirect enzyme-linked inmunoabsorbent assay (ELISA). Totally 4 hybridoma clones were obtained and these mAbs were IgG1 (3 clones) and IgG2a (1 clone), respectively. Their light chains were all kappa chains.Western blotting analysis and confocal immunofluorescence assays demonstrated that mAbs could specifically recognize EGFR expressing on A431 carcinoma cell line. The mAbs will be useful in the study of EGFR-mediated signal transduction.

  2. Expression of Intracellular Domain of Epidermal Growth Factor Receptor and Generation of Its Monoclonal Antibody

    Institute of Scientific and Technical Information of China (English)

    YingLin; ZhiduoLiu; JianminJiang; ZiqingJiang; Yongyongji; BingSun

    2004-01-01

    To prepare monoclonal antibody specific to epidermal growth factor receptor (EGFR) intracellular domain, its gene was amplified from total RNA of A431 cell by RT-PCR. Then the gene was cloned into prokaryotic vector pET30a(+). The recombinant plasmid was transformed into E. coli BL21 (DE3) strain for protein expression. Recombinant protein was induced with IPTG and purified using Nie2+-NTA agarose. Then the anti-EGFR monoclonal antibody (mAb) was prepared with classical hybridoma technique. Positive clones were selected using indirect enzyme-linked immunoabsorbent assay (ELISA). Totally 4 hybridoma clones were obtained and these mAbs were IgG1 (3 clones) and IgG2a (1 clone), respectively. Their light chains were all kappa chains. Western blotting analysis and confocal immunofluorescence assays demonstrated that mAbs could specifically recognize EGFR expressing on A431 carcinoma cell line. The mAbs will be useful in the study of EGFR-mediated signal transduction. Cellular & Molecular Immunology. 2004;1(2):137-141.

  3. An establishment of MELCOR code to generate source terms for off site consequence analysis

    Energy Technology Data Exchange (ETDEWEB)

    Park, S. H.; Han, S.; Ahn, K. I. [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    Since the Fukushima accident, an effective approach to a source term analysis for off site consequence analyses has been needed. The MELCOR code has the capability to assess the source term characteristics for this kind of demand. A comprehensive effort is required to use the MELCOR code for a source term analysis effectively. For this purpose, the following works are required: - Review and assess the MELCOR model relevant to source term characterization - Generate input files for source term analysis - Utilize the source term parameters This paper shows an effort to establish the MELCOR code to generate source terms for an off site consequence analysis.

  4. Human Factors Process Task Analysis: Liquid Oxygen Pump Acceptance Test Procedure at the Advanced Technology Development Center

    Science.gov (United States)

    Diorio, Kimberly A.; Voska, Ned (Technical Monitor)

    2002-01-01

    This viewgraph presentation provides information on Human Factors Process Failure Modes and Effects Analysis (HF PFMEA). HF PFMEA includes the following 10 steps: Describe mission; Define System; Identify human-machine; List human actions; Identify potential errors; Identify factors that effect error; Determine likelihood of error; Determine potential effects of errors; Evaluate risk; Generate solutions (manage error). The presentation also describes how this analysis was applied to a liquid oxygen pump acceptance test.

  5. A factor analysis of the SSQ (Speech, Spatial, and Qualities of Hearing Scale).

    Science.gov (United States)

    Akeroyd, Michael A; Guy, Fiona H; Harrison, Dawn L; Suller, Sharon L

    2014-02-01

    The speech, spatial, and qualities of hearing questionnaire (SSQ) is a self-report test of auditory disability. The 49 items ask how well a listener would do in many complex listening situations illustrative of real life. The scores on the items are often combined into the three main sections or into 10 pragmatic subscales. We report here a factor analysis of the SSQ that we conducted to further investigate its statistical properties and to determine its structure. Statistical factor analysis of questionnaire data, using parallel analysis to determine the number of factors to retain, oblique rotation of factors, and a bootstrap method to estimate the confidence intervals. 1220 people who have attended MRC IHR over the last decade. We found three clear factors, essentially corresponding to the three main sections of the SSQ. They are termed "speech understanding", "spatial perception", and "clarity, separation, and identification". Thirty-five of the SSQ questions were included in the three factors. There was partial evidence for a fourth factor, "effort and concentration", representing two more questions. These results aid in the interpretation and application of the SSQ and indicate potential methods for generating average scores.

  6. Retinopathy risk factors in type II diabetic patients using factor analysis and discriminant analysis

    OpenAIRE

    Tazhibi, Mahdi; Sarrafzade, Sheida; Amini, Masoud

    2014-01-01

    Introduction: Diabetes is one of the most common chronic diseases in the world. Incidence and prevalence of diabetes are increasing in developing countries as well as in Iran. Retinopathy is the most common chronic disorder in diabetic patients. Materials and Methods: In this study, we used the information of diabetic patients’ reports that refer to endocrine and metabolism research center of Isfahan University of Medical Sciences to determine diabetic retinopathy risk factors. We used factor...

  7. Generation and characterization of a panel of monoclonal antibodies specific for human fibroblast growth factor receptor 4 (FGFR4).

    Science.gov (United States)

    Chen, Chaoyuan; Patel, Sima; Corisdeo, Susanne; Liu, Xiangdong; Micolochick, Holly; Xue, Jiyang; Yang, Qifeng; Lei, Ying; Wang, Baiyang; Soltis, Daniel

    2005-06-01

    Fibroblast growth factor receptor 4 (FGFR4) is a member of the FGFR family of receptor tyrosine kinases, and plays important roles in a variety of biological functions such as cell proliferation, differentiation, migration, angiogenesis, tissue repair, and tumorigenesis. The human FGFRs share a high degree of sequence homology between themselves, as well as with their murine homologs. Consequently, it has been suggested that it may be difficult to prepare monoclonal antibodies (MAbs) that are specific for the individual receptor types. In this communication, we report on the development and characterization of a panel of anti-human FGFR4 MAbs that were generated in mice using a rapid immunization protocol. Using a modified rapid immunization at multiple sites (RIMMS) protocol with the soluble extracellular domain of human FGFR4 (FGFR4-ECD), the immunized mice developed high levels of polyclonal IgG to the immunogen within 13 days of the first immunization. The lymph node cells isolated from the immunized animals were then fused with mouse myeloma cells for hybridoma generation. Use of an efficient hybridoma cloning protocol in combination with an ELISA screening procedure allowed for early identification of stable hybridomas secreting antihuman FGFR4 IgG. Several identified MAbs specifically reacted with the FGFR4 protein without binding to the other human isoforms (FGFR1, FGFR2, and FGFR3). As evaluated by BIAcore analysis, most anti-FGFR4 MAbs displayed high affinities (8.6 x 10(8) approximately 3.9 x 10(10) M) to FGFR4. Furthermore, these MAbs were able to bind to FGFR4 expressed on human breast tumor cell lines MDA-MB-361 and MDA-MB-453. Taken together, the results demonstrate that the RIMMS strategy is an effective approach for generating class-switched, high-affinity MAbs in mice to evolutionarily conserved proteins such as human FGFR4. These MAbs may be useful tools for further investigation of the biological functions and pathological roles of human FGFR4.

  8. The analysis of an operating mode of the asynchronous generator with capacitor excitation

    Directory of Open Access Journals (Sweden)

    Postoronca S.

    2008-08-01

    Full Text Available On the basis of a symbolical method of calculation of electric circuits the analysis of features of work of the three-phase asynchronous generator with two windings on статоре and capacitor excitation is executed. Results of the analysis of influence on a phase corner of a current and voltage of a windings of excitation of the generator are submitted at change of its loading from a mode of idling up to a mode of short circuit. Recommendations on stabilization of a target voltage of the generator are formulated at change of its loading.

  9. Methods for Dynamic Analysis of Distribution Feeders with High Penetration of PV Generators

    Energy Technology Data Exchange (ETDEWEB)

    Nagarajan, Adarsh; Ayyanar, Raja

    2016-11-21

    An increase in the number of inverter-interfaced photovoltaic (PV) generators on existing distribution feeders affects the design, operation, and control of the distribution systems. Existing distribution system analysis tools are capable of supporting only snapshot and quasi-static analyses. Capturing the dynamic effects of PV generators during the variation in distribution system states is necessary when studying the effects of controller bandwidths, multiple voltage correction devices, and anti-islanding. This work explores the use of dynamic phasors and differential algebraic equations (DAE) for impact analysis of PV generators on the existing distribution feeders.

  10. Fuel prices scenario generation based on a multivariate GARCH model for risk analysis in a wholesale electricity market

    Energy Technology Data Exchange (ETDEWEB)

    Batlle, C.; Barquin, J. [Universidad Pontifica Comillas, Madrid (Spain). Instituto de Investigacion Tecnologica

    2004-05-01

    This paper presents a fuel prices scenario generator in the frame of a simulation tool developed to support risk analysis in a competitive electricity environment. The tool feeds different erogenous risk factors to a wholesale electricity market model to perform a statistical analysis of the results. As the different fuel series that are studied, such as the oil or gas ones, present stochastic volatility and strong correlation among them, a multivariate Generalized Autoregressive Conditional Heteroskedastic (GARCH) model has been designed in order to allow the generation of future fuel prices paths. The model makes use of a decomposition method to simplify the consideration of the multidimensional conditional covariance. An example of its application with real data is also presented. (author)

  11. TRANSIENT STABILITY ANALYSIS OF PERMANENT MAGNET SYNCHRONOUS GENERATOR WITH TWO LEVEL CONVERTER INVERTER

    Directory of Open Access Journals (Sweden)

    KRISHNA KUMARI.T

    2013-04-01

    Full Text Available Wind energy plays a prominent role in the generation of power from renewable sources. Generation by permanent magnet synchronous generator (PMSG is recently been popular. But the major concern in using this generator is that the voltage and the power generated are variable due to the intermittent nature of wind energy. Because of the wide use of PMSG the study of the transient stability analysis is very important. In this paper the performance study of PMSG is done by using suitable control strategies to develop a constant voltage and power. The transient stability analysis is also carried out by simulating both the symmetrical and the unsymmetrical faults as network disturbances. This is demonstrated using MATLAB simulations.

  12. Updated greenhouse gas and criteria air pollutant emission factors and their probability distribution functions for electricity generating units

    Energy Technology Data Exchange (ETDEWEB)

    Cai, H.; Wang, M.; Elgowainy, A.; Han, J. (Energy Systems)

    2012-07-06

    Greenhouse gas (CO{sub 2}, CH{sub 4} and N{sub 2}O, hereinafter GHG) and criteria air pollutant (CO, NO{sub x}, VOC, PM{sub 10}, PM{sub 2.5} and SO{sub x}, hereinafter CAP) emission factors for various types of power plants burning various fuels with different technologies are important upstream parameters for estimating life-cycle emissions associated with alternative vehicle/fuel systems in the transportation sector, especially electric vehicles. The emission factors are typically expressed in grams of GHG or CAP per kWh of electricity generated by a specific power generation technology. This document describes our approach for updating and expanding GHG and CAP emission factors in the GREET (Greenhouse Gases, Regulated Emissions, and Energy Use in Transportation) model developed at Argonne National Laboratory (see Wang 1999 and the GREET website at http://greet.es.anl.gov/main) for various power generation technologies. These GHG and CAP emissions are used to estimate the impact of electricity use by stationary and transportation applications on their fuel-cycle emissions. The electricity generation mixes and the fuel shares attributable to various combustion technologies at the national, regional and state levels are also updated in this document. The energy conversion efficiencies of electric generating units (EGUs) by fuel type and combustion technology are calculated on the basis of the lower heating values of each fuel, to be consistent with the basis used in GREET for transportation fuels. On the basis of the updated GHG and CAP emission factors and energy efficiencies of EGUs, the probability distribution functions (PDFs), which are functions that describe the relative likelihood for the emission factors and energy efficiencies as random variables to take on a given value by the integral of their own probability distributions, are updated using best-fit statistical curves to characterize the uncertainties associated with GHG and CAP emissions in life

  13. Updated greenhouse gas and criteria air pollutant emission factors and their probability distribution functions for electricity generating units

    Energy Technology Data Exchange (ETDEWEB)

    Cai, H.; Wang, M.; Elgowainy, A.; Han, J. (Energy Systems)

    2012-07-06

    Greenhouse gas (CO{sub 2}, CH{sub 4} and N{sub 2}O, hereinafter GHG) and criteria air pollutant (CO, NO{sub x}, VOC, PM{sub 10}, PM{sub 2.5} and SO{sub x}, hereinafter CAP) emission factors for various types of power plants burning various fuels with different technologies are important upstream parameters for estimating life-cycle emissions associated with alternative vehicle/fuel systems in the transportation sector, especially electric vehicles. The emission factors are typically expressed in grams of GHG or CAP per kWh of electricity generated by a specific power generation technology. This document describes our approach for updating and expanding GHG and CAP emission factors in the GREET (Greenhouse Gases, Regulated Emissions, and Energy Use in Transportation) model developed at Argonne National Laboratory (see Wang 1999 and the GREET website at http://greet.es.anl.gov/main) for various power generation technologies. These GHG and CAP emissions are used to estimate the impact of electricity use by stationary and transportation applications on their fuel-cycle emissions. The electricity generation mixes and the fuel shares attributable to various combustion technologies at the national, regional and state levels are also updated in this document. The energy conversion efficiencies of electric generating units (EGUs) by fuel type and combustion technology are calculated on the basis of the lower heating values of each fuel, to be consistent with the basis used in GREET for transportation fuels. On the basis of the updated GHG and CAP emission factors and energy efficiencies of EGUs, the probability distribution functions (PDFs), which are functions that describe the relative likelihood for the emission factors and energy efficiencies as random variables to take on a given value by the integral of their own probability distributions, are updated using best-fit statistical curves to characterize the uncertainties associated with GHG and CAP emissions in life

  14. Generation of Wheat Transcription Factor FOX Rice Lines and Systematic Screening for Salt and Osmotic Stress Tolerance.

    Directory of Open Access Journals (Sweden)

    Jinxia Wu

    Full Text Available Transcription factors (TFs play important roles in plant growth, development, and responses to environmental stress. In this study, we collected 1,455 full-length (FL cDNAs of TFs, representing 45 families, from wheat and its relatives Triticum urartu, Aegilops speltoides, Aegilops tauschii, Triticum carthlicum, and Triticum aestivum. More than 15,000 T0 TF FOX (Full-length cDNA Over-eXpressing rice lines were generated; of these, 10,496 lines set seeds. About 14.88% of the T0 plants showed obvious phenotypic changes. T1 lines (5,232 lines were screened for salt and osmotic stress tolerance using 150 mM NaCl and 20% (v/v PEG-4000, respectively. Among them, five lines (591, 746, 1647, 1812, and J4065 showed enhanced salt stress tolerance, five lines (591, 746, 898, 1078, and 1647 showed enhanced osmotic stress tolerance, and three lines (591, 746, and 1647 showed both salt and osmotic stress tolerance. Further analysis of the T-DNA flanking sequences showed that line 746 over-expressed TaEREB1, line 898 over-expressed TabZIPD, and lines 1812 and J4065 over-expressed TaOBF1a and TaOBF1b, respectively. The enhanced salt and osmotic stress tolerance of lines 898 and 1812 was confirmed by retransformation of the respective genes. Our results demonstrate that a heterologous FOX system may be used as an alternative genetic resource for the systematic functional analysis of the wheat genome.

  15. Personality and coping traits: A joint factor analysis.

    Science.gov (United States)

    Ferguson, Eamonn

    2001-11-01

    OBJECTIVES: The main objective of this paper is to explore the structural similarities between Eysenck's model of personality and the dimensions of the dispositional COPE. Costa et al. {Costa P., Somerfield, M., & McCrae, R. (1996). Personality and coping: A reconceptualisation. In (pp. 44-61) Handbook of coping: Theory, research and applications. New York: Wiley} suggest that personality and coping behaviour are part of a continuum based on adaptation. If this is the case, there should be structural similarities between measures of personality and coping behaviour. This is tested using a joint factor analysis of personality and coping measures. DESIGN: Cross-sectional survey. METHODS: The EPQ-R and the dispositional COPE were administered to 154 participants, and the data were analysed using joint factor analysis and bivariate associations. RESULTS: The joint factor analysis indicated that these data were best explained by a four-factor model. One factor was primarily unrelated to personality. There was a COPE-neurotic-introvert factor (NI-COPE) containing coping behaviours such as denial, a COPE-extroversion (E-COPE) factor containing behaviours such as seeking social support and a COPE-psychoticism factor (P-COPE) containing behaviours such as alcohol use. This factor pattern, especially for NI- and E-COPE, was interpreted in terms of Gray's model of personality {Gray, J. A. (1987) The psychology of fear and stress. Cambridge: Cambridge University Press}. NI-, E-, and P-COPE were shown to be related, in a theoretically consistent manner, to perceived coping success and perceived coping functions. CONCLUSIONS: The results indicate that there are indeed conceptual links between models of personality and coping. It is argued that future research should focus on identifying coping 'trait complexes'. Implications for practice are discussed.

  16. Emotional experiences and motivating factors associated with fingerprint analysis.

    Science.gov (United States)

    Charlton, David; Fraser-Mackenzie, Peter A F; Dror, Itiel E

    2010-03-01

    In this study, we investigated the emotional and motivational factors involved in fingerprint analysis in day-to-day routine case work and in significant and harrowing criminal investigations. Thematic analysis was performed on interviews with 13 experienced fingerprint examiners from a variety of law enforcement agencies. The data revealed factors relating to job satisfaction and the use of skill. Individual satisfaction related to catching criminals was observed; this was most notable in solving high profile, serious, or long-running cases. There were positive emotional effects associated with matching fingerprints and apparent fear of making errors. Finally, we found evidence for a need of cognitive closure in fingerprint examiner decision-making.

  17. Unascertained Factor Method of Dynamic Characteristic Analysis for Antenna Structures

    Institute of Scientific and Technical Information of China (English)

    ZHU Zeng-qing; LIANG Zhen-tao; CHEN Jian-jun

    2008-01-01

    The dynamic characteristic analysis model of antenna structures is built, in which the structural physical parameters and geometrical dimensions are all considered as unascertained variables, And a structure dynamic characteristic analysis method based on the unascertained factor method is given. The computational expression of structural characteristic is developed by the mathematics expression of unascertained factor and the principles of unascertained rational numbers arithmetic. An example is given, in which the possible values and confidence degrees of the unascertained structure characteristics are obtained. The calculated results show that the method is feasible and effective.

  18. Using Factor Analysis to Identify Topic Preferences Within MBA Courses

    Directory of Open Access Journals (Sweden)

    Earl Chrysler

    2003-02-01

    Full Text Available This study demonstrates the role of a principal components factor analysis in conducting a gap analysis as to the desired characteristics of business alumni. Typically, gap analyses merely compare the emphases that should be given to areas of inquiry with perceptions of actual emphases. As a result, the focus is upon depth of coverage. A neglected area in need of investigation is the breadth of topic dimensions and their differences between the normative (should offer and the descriptive (actually offer. The implications of factor structures, as well as traditional gap analyses, are developed and discussed in the context of outcomes assessment.

  19. Analysis of Effect of Heat Pipe Parameters in Minimising the Entropy Generation Rate

    Directory of Open Access Journals (Sweden)

    Rakesh Hari

    2016-01-01

    Full Text Available Heat transfer and fluid flow in the heat pipe system result in thermodynamic irreversibility generating entropy. The minimum entropy generation principle can be used for optimum design of flat heat pipe. The objective of the present work is to minimise the total entropy generation rate as the objective function with different parameters of the flat heat pipe subjected to some constraints. These constraints constitute the limitations on the heat transport capacity of the heat pipe. This physical nonlinear programming problem with nonlinear constraints is solved using LINGO 15.0 software, which enables finding optimum values for the independent design variables for which entropy generation is minimum. The effect of heat load, length, and sink temperature on design variables and corresponding entropy generation is studied. The second law analysis using minimum entropy generation principle is found to be effective in designing performance enhanced heat pipe.

  20. Confirmatory Factor Analysis of the Procrastination Assessment Scale for Students

    Directory of Open Access Journals (Sweden)

    Ronald D. Yockey

    2015-10-01

    Full Text Available The relative fit of one- and two-factor models of the Procrastination Assessment Scale for Students (PASS was investigated using confirmatory factor analysis on an ethnically diverse sample of 345 participants. The results indicated that although the two-factor model provided better fit to the data than the one-factor model, neither model provided optimal fit. However, a two-factor model which accounted for common item theme pairs used by Solomon and Rothblum in the creation of the scale provided good fit to the data. In addition, a significant difference by ethnicity was also found on the fear of failure subscale of the PASS, with Whites having significantly lower scores than Asian Americans or Latino/as. Implications of the results are discussed and recommendations made for future work with the scale.

  1. Analysis of Factors Influencing Farmers’ Identification of Entrepreneurial Opportunity

    Institute of Scientific and Technical Information of China (English)

    Jing; GAO; Fang; YANG

    2013-01-01

    Based on the survey data of entrepreneurship concerning farmers in China,this article uses the multivariate adjustment regression analysis method,to analyze the factors influencing farmers’ identification of entrepreneurial opportunity and the mechanism. The results show that demographic characteristics are still an important factor influencing farmers’ identification of entrepreneurial opportunity,but the extent of its influence is weaker than entrepreneurs’ trait. The new trait theory is verified in farmers’ entrepreneurship opportunity behavior; entrepreneurship environment is becoming an important factor influencing entrepreneurial opportunity identification,whose regulation effect on entrepreneurs’ social network and previous experience is stronger than the regulation effect on entrepreneurs’ psychological trait.

  2. A factor analysis to find critical success factors in retail brand

    Directory of Open Access Journals (Sweden)

    Naser Azad

    2013-03-01

    Full Text Available The present exploratory study aims to find critical components of retail brand among some retail stores. The study seeks to build a brand name in retail level and looks to find important factors affecting it. Customer behavior is largely influenced when the first retail customer experience is formed. These factors have direct impacts on customer experience and satisfaction in retail industry. The proposed study performs an empirical investigation on two well-known retain stores located in city of Tehran, Iran. Using a sample of 265 people from regular customers, the study uses factor analysis and extracts four main factors including related brand, product benefits, customer welfare strategy and corporate profits using the existing 31 factors in the literature.

  3. Generational differences on craft workers' perceptions of the factors affecting labour productivity

    National Research Council Canada - National Science Library

    Dai, Jiukun; Goodrum, Paul M

    2012-01-01

    .... The shortage could become more substantial because the U.S. construction industry is poised to make a significant demographic shift with Baby Boomer workers approaching retirement and Generation Y workers joining the workforce...

  4. Factors Influencing Compensation Demanded for Environmental Impacts Generated by Different Economic Activities

    National Research Council Canada - National Science Library

    Gutiérrez, Virna; Cifuentes, Luis; Bronfman, Nicolás

    2015-01-01

    ... (as perceived risk, public acceptability and trust in regulating authorities), and to explore whether these relationships depend on the environment affected and on the economic activity generating the impacts...

  5. Exploring factors that influence customer loyalty among Generation Y for the fast food industry in Malaysia

    National Research Council Canada - National Science Library

    Kwek Choon Ling; Yeong Wai Mun; Hiew Mee Ling

    2011-01-01

      The consumption of western fast foods has been on the upward trend. As such, it is vital to identify the determinants of the customer loyalty among Generation Y in Malaysia, especially in the western fast food industry...

  6. Ranking insurance firms using AHP and Factor Analysis

    Directory of Open Access Journals (Sweden)

    Mohammad Khodaei Valahzaghard

    2013-03-01

    Full Text Available Insurance industry includes a significant part of economy and it is important to learn more about the capabilities of different firms, which are active in this industry. In this paper, we present an empirical study to rank the insurance firms using analytical hierarchy process as well as factor analysis. The study considers four criteria including capital adequacy, quality of earning, quality of cash flow and quality of firms’ assets. The results of the implementation of factor analysis (FA have been verified using Kaiser-Meyer-Olkin (KMO=0.573 and Bartlett's Chi-Square (443.267 P-value=0.000 tests. According to the results FA, the first important factor, capital adequacy, represents 21.557% of total variance, the second factor, quality of income, represents 20.958% of total variance. In addition, the third factor, quality of cash flow, represents 19.417% of total variance and the last factor, quality of assets, represents 18.641% of total variance. The study has also used analytical hierarchy process (AHP to rank insurance firms. The results of our survey indicate that capital adequacy (0.559 is accounted as the most important factor followed by quality of income (0.235, quality of cash flow (0.144 and quality of assets (0.061. The results of AHP are consistent with the results of FA, which somewhat validates the overall study.

  7. Workplace Innovation: Exploratory and Confirmatory Factor Analysis for Construct Validation

    Directory of Open Access Journals (Sweden)

    Wipulanusat Warit

    2017-06-01

    Full Text Available Workplace innovation enables the development and improvement of products, processes and services leading simultaneously to improvement in organisational performance. This study has the purpose of examining the factor structure of workplace innovation. Survey data, extracted from the 2014 APS employee census, comprising 3,125 engineering professionals in the Commonwealth of Australia’s departments were analysed using exploratory factor analysis (EFA and confirmatory factor analysis (CFA. EFA returned a two-factor structure explaining 69.1% of the variance of the construct. CFA revealed that a two-factor structure was indicated as a validated model (GFI = 0.98, AGFI = 0.95, RMSEA = 0.08, RMR = 0.02, IFI = 0.98, NFI = 0.98, CFI = 0.98, and TLI = 0.96. Both factors showed good reliability of the scale (Individual creativity: α = 0.83, CR = 0.86, and AVE = 0.62; Team Innovation: α = 0.82, CR = 0.88, and AVE = 0.61. These results confirm that the two factors extracted for characterising workplace innovation included individual creativity and team innovation.

  8. Analysis of plug-in hybrid electric vehicle utility factors

    Science.gov (United States)

    Bradley, Thomas H.; Quinn, Casey W.

    Plug-in hybrid electric vehicles (PHEVs) are hybrid electric vehicles that can be fueled from both conventional liquid fuels and grid electricity. To represent the total contribution of both of these fuels to the operation, energy use, and environmental impacts of PHEVs, researchers have developed the concept of the utility factor. As standardized in documents such as SAE J1711 and SAE J2841, the utility factor represents the proportion of vehicle distance travelled that can be allocated to a vehicle test condition so as to represent the real-world driving habits of a vehicle fleet. These standards must be used with care so that the results are understood within the context of the assumptions implicit in the standardized utility factors. This study analyzes and derives alternatives to the standard utility factors from the 2001 National Highway Transportation Survey, so as to understand the sensitivity of PHEV performance to assumptions regarding charging frequency, vehicle characteristics, driver characteristics, and means of defining the utility factor. Through analysis of these alternative utility factors, this study identifies areas where analysis, design, and policy development for PHEVs can be improved by alternative utility factor calculations.

  9. Bone dynamic study. Evaluation for factor analysis of hip joint

    Energy Technology Data Exchange (ETDEWEB)

    Nakajima, Kotaro; Toyama, Hinako; Ishikawa, Nobuyoshi; Hatakeyama, Rokuro; Akisada, Masayoshi; Miyagawa, Shunpei

    1989-02-01

    Factor analysis was applied to dynamic study of Tc-99m MDP for the evaluation of hip joint disorders. Fifteen patients were examined; eight were normal, six was osteoarthritis in which one accompanied synovitis was included, and one was aseptic necrosis on the head of the femur. In normals, according to the Tc-99m MDP kinetics, three factor images and time-activity curves were obtained which were named as blood vessel, soft tissue, and bone factor images and curves. In the patient with osteoarthritis, increased accumulation of the hip joint was shown in bone factor image only. But in one patient, who took osteoarthritis with synovitis, marked accumulations of the Tc-99m MDP appeared not only on the bone factor image but also on the soft tissue. Operation revealed thickening synovial tissue around the hip joint, caused by inflammatory process. In follow-up studies of the patient with aseptic necrosis on the head of the left femur, exessive accumulations, which were seemed in his left hip joint on both bone and soft tissue factor images at first, were decreased respondently to the treatment of this lesion. In conclusion, the factor analysis was useful for differential diagnosis of the hip joint disorders and observation of the clinical course of the hip joint disorders.

  10. Clinical Experience with First-generation Epidermal Growth Factor Receptor 
Tyrosine Kinase Inhibitors in Non-small Cell Lung Cancer Patients 
with Brain Metastasis

    Directory of Open Access Journals (Sweden)

    Huixing DONG

    2017-02-01

    Full Text Available Background and objective A survival analysis and the influencing factors for non-small cell lung cancer (NSCLC patients with brain metastases accepting first-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs treatment have not yet been elucidated to date. In this study, we collected and analyzed the survival data of NSCLC patients with brain metastasis to obtain evidence and to provide guidance in clinical practice. Methods NSCLC patients with brain metastases who were treated with first-generation EGFR-TKIs were retrospectively collected in 2012-2013 from Shanghai Chest Hospital, Shanghai Jiao Tong University. The Kaplan-Meier method and Cox regression were performed for univariate and multivariate analyses, respectively, to explore the independent predictors influencing the survival of patients with NSCLC brain metastases. Results The median progression-free survival (PFS and median overall survival (OS of all patients treated with first-generation EGFR-TKIs were 10.0 months (95%CI: 8.3-11.7 and 28.0 months (95%CI: 22.9-33.1, respectively. Pathological subtypes were the independent predictors of PFS (P=0.001, and tumor differentiations were the independent predictors of OS (P=0.050. Conclusion First-generation EGFR-TKIs showed promising efficacy in NSCLC patients with brain metastases. PFS was longer in patients with adenocarcinoma than in those with a non-adenocarcinoma subtype. OS was longer in patients with differentiated tumors than in those who developed poorly differentiated tumors.

  11. Analysis of the energy portfolio for electricity generation; Analisis del portafolio energetico para la generacion electrica

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez S, J. R.; Alonso V, G.; Esquivel E, J., E-mail: ramon.ramirez@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2016-09-15

    The planning of electricity generation systems considers several factors that must be taken into account in order to design systems that are economical, reliable and sustainable. For this purpose, the Financial Portfolio Theory is applicable to the energy portfolio or the diversification of electricity generation technologies, such as is the combined cycle, wind, thermoelectric and nuclear. This paper presents an application of the Portfolio Theory to the national energy system, based on the total generation costs for each technology, which allows determining the average variance portfolio and the respective share of each of the electricity generation technologies considered, obtaining a portfolio of electricity generation with the maximum possible return for the risk taken in the investments. This paper describes the basic aspects of the Portfolio Theory and its methodology, in which matrices are implemented for the solution of the resulting Lagrange system. (Author)

  12. A Brief History of the Philosophical Foundations of Exploratory Factor Analysis.

    Science.gov (United States)

    Mulaik, Stanley A.

    1987-01-01

    Exploratory factor analysis derives its key ideas from many sources, including Aristotle, Francis Bacon, Descartes, Pearson and Yule, and Kant. The conclusions of exploratory factor analysis are never complete without subsequent confirmatory factor analysis. (Author/GDC)

  13. Type I and Type II Error Rates and Overall Accuracy of the Revised Parallel Analysis Method for Determining the Number of Factors

    Science.gov (United States)

    Green, Samuel B.; Thompson, Marilyn S.; Levy, Roy; Lo, Wen-Juo

    2015-01-01

    Traditional parallel analysis (T-PA) estimates the number of factors by sequentially comparing sample eigenvalues with eigenvalues for randomly generated data. Revised parallel analysis (R-PA) sequentially compares the "k"th eigenvalue for sample data to the "k"th eigenvalue for generated data sets, conditioned on"k"-…

  14. 伊马替尼耐药或不耐受的 CML 患者更换二代 TKI治疗的疗效观察及相关因素分析%The curative effect observation and relevant factors analysis of the second generation TKI drugs after imatinib resistance or intolerance in chronic myeloid leukemia patients

    Institute of Scientific and Technical Information of China (English)

    安福润; 杨明珍; 曾庆曙; 王永庆; 葛健; 王霖; 阮敏; 陈莹莹; 顾悦

    2015-01-01

    Objective To observe the curative effect of second generation TKI drugs and analyze the influence of relevant factors in chronic myeloid leukemia (CML) patients with imatinib resistance or intolerance. Methods The patients with Imatinib resistance or intolerance and had switched to the second generation TKI drugs, were se-lected randomly 25 each group. Then, monitored their BCR/ ABL fusion gene quantitative results in the 3rd month or 6th month, analyzed the relationship between achieving BCR/ ABL≤10% within 6 months and relevant factors, including the reason, phase and hematologic remission status while changing drug, and the adherence after the changing. Results There were 16 imatinib resistance patients (41. 0% ) and 9 Imatinib intolerance patients (81. 8% ) who had achieved BCR/ ABL≤10% within 6 months after changing. There were 23 patients(76. 7% ) in chronic phase (CP) and 2 patients(10. 0% ) in advanced phase(blastic phase BP or accelerated phase AP) while changing, who had achieved BCR/ ABL≤10% within 6 months. 16 patients(72. 7% ) had changed drug with complete hematologic remission (CHR) and 9 patients(32. 1% ) without CHR, then achieved BCR/ ABL≤10% within 6 months. 23 patients(74. 2% ) with good adherence of the second generation TKI drugs and 2 patients (10. 5% ) with bad adherence, had achieved BCR/ ABL≤10% within 6 months. Conclusion There is a certain effect on imatinib-resistant or intolerant CML patients who have switched to second-generation TKI drugs. And the difference between the efficacy of these two second-generation TKI drugs (Dasatinib, Nilotinib) is not statistically significant. The imatinib intolerance patients get better effect than the imatinib resistance patients. The patients in CP get better effect than the patients in advanced phase, while changing drug, the patients with CHR get better effect than the patients without CHR. The patients with good adherence of the second generation TKI drugs get bet-ter effect than the

  15. Induced Land Use Emissions due to First and Second Generation Biofuels and Uncertainty in Land Use Emission Factors

    Directory of Open Access Journals (Sweden)

    Farzad Taheripour

    2013-01-01

    Full Text Available Much research has estimated induced land use changes (ILUCs and emissions for first generation biofuels. Relatively little has provided estimates for the second generation biofuels. This paper estimates ILUC emissions for the first and second generation biofuels. Estimated ILUC emissions are uncertain not only because their associated land use changes are uncertain, but also because of uncertainty in the land use emission factors (EFs. This paper also examines uncertainties related to these factors. The results suggest that converting crop residues to biofuel has no significant ILUC emissions, but that is not the case for dedicated energy crops. Use of dedicated energy crops transfers managed natural land and marginal land (cropland-pasture to crop production. Producing biogasoline from miscanthus generates the lowest land requirement among alterative pathways. The largest land requirement is associated with switchgrass. The difference is due largely to the assumed yields of switchgrass and miscanthus. The three major conclusions from uncertainty in emissions analyses are (1 inclusion or exclusion of cropland-pasture makes a huge difference; (2 changes in soil carbon sequestration due to changes in land cover vegetation play an important role; and (3 there is wide divergence among the emission factor sources, especially for dedicated crop conversion to ethanol.

  16. Critical Analysis of Textbooks: Knowledge-Generating Logics and the Emerging Image of "Global Economic Contexts"

    Science.gov (United States)

    Thoma, Michael

    2017-01-01

    This paper presents an approach to the critical analysis of textbook knowledge, which, working from a discourse theory perspective (based on the work of Foucault), refers to the performative nature of language. The critical potential of the approach derives from an analysis of knowledge-generating logics, which produce particular images of reality…

  17. Alternatives generation and analysis for phase I intermediate waste feed staging system design requirements

    Energy Technology Data Exchange (ETDEWEB)

    Britton, M.D.

    1996-10-02

    This document provides; a decision analysis summary; problem statement; constraints, requirements, and assumptions; decision criteria; intermediate waste feed staging system options and alternatives generation and screening; intermediate waste feed staging system design concepts; intermediate waste feed staging system alternative evaluation and analysis; and open issues and actions.

  18. Analysis of spiritual pressure of the Beat Generation in On the Road

    Institute of Scientific and Technical Information of China (English)

    刘英波

    2015-01-01

    This paper aims to make an analysis of the double spiritual pressure of the Beat Generation in On the Road. Through the analysis, it shows the readers an actual American society after the World War II, and spiritual pressures that American young people meet.

  19. Critical Analysis of Textbooks: Knowledge-Generating Logics and the Emerging Image of "Global Economic Contexts"

    Science.gov (United States)

    Thoma, Michael

    2017-01-01

    This paper presents an approach to the critical analysis of textbook knowledge, which, working from a discourse theory perspective (based on the work of Foucault), refers to the performative nature of language. The critical potential of the approach derives from an analysis of knowledge-generating logics, which produce particular images of reality…

  20. Behavioural risk factors in two generations of non-Western migrants: do trends converge towards the host population?

    Science.gov (United States)

    Hosper, Karen; Nierkens, Vera; Nicolaou, Mary; Stronks, Karien

    2007-01-01

    Migrant mortality does not conform to a single pattern of convergence towards prevalence rates in the host population. To understand better how migrant mortality develops, it is necessary to further investigate how the underlying behavioural determinants change following migration. We studied whether the prevalence of behavioural risk factors over two generations of Turkish and Moroccan migrants converge towards the prevalence rates in the Dutch population. From a random sample from the population register of Amsterdam, 291 Moroccan and 505 Turkish migrants, aged 15-30, participated in a structured interview that included questions on smoking, alcohol consumption, physical inactivity and weight/height. Data from the Dutch population were available from Statistics Netherlands. By calculating age-adjusted Odds Ratio's, prevalence rates among both generations were compared with prevalence rates in the host population for men and women separately. We found indications of convergence across generations towards the prevalence rates in the host population for smoking in Turkish men, for overweight in Turkish and Moroccan women and for physical inactivity in Turkish women. Alcohol consumption, however, remained low in all subgroups and did not converge towards the higher rates in the host population. In addition, we found a reversed trend among Turkish women regarding smoking: the second generation smoked significantly more, while the first generation did not differ from ethnic Dutch. In general, behavioural risk factors in two generations of non-Western migrants in the Netherlands seem to converge towards the prevalence rates in the Dutch population. However, some subgroups and risk factors showed a different pattern.