WorldWideScience

Sample records for facility types involved

  1. Stakeholder involvement in decommissioning nuclear facilities

    International Nuclear Information System (INIS)

    2007-01-01

    Significant numbers of nuclear facilities will need to be decommissioned in the coming decades. In this context, NEA member countries are placing increasing emphasis on the involvement of stakeholders in the associated decision procedures. This study reviews decommissioning experience with a view to identifying stakeholder concerns and best practice in addressing them. The lessons learnt about the end of the facility life cycle can also contribute to better foresight in siting and building new facilities. This report will be of interest to all major players in the field of decommissioning, in particular policy makers, implementers, regulators and representatives of local host communities

  2. Stakeholder Involvement Throughout the Life Cycle of Nuclear Facilities

    International Nuclear Information System (INIS)

    2011-01-01

    This report demonstrates the importance of stakeholder involvement throughout the life cycle of all nuclear facilities; including operating reactors, temporary spent fuel storage facilities and final radioactive waste repositories and follows what is defined in the IAEA Safety Standards GS-R-3 where the stakeholders' expectations (identified as 'interested parties' in GS-R-3) shall be taken into consideration 'in the activities and interactions in the processes of the management system, with the aim of enhancing the satisfaction of interested parties while at the same time ensuring that safety is not compromised'. This report explains how involving stakeholders in decision making processes, even for those stakeholder groups that do not have a direct role in making those decisions, can enhance public confidence in the application of nuclear science and technology. In addition, this report presents general guidance on stakeholder involvement. It does not provide detailed procedures for developing and implementing stakeholder involvement programmes, and specifics regarding stakeholder involvement for particular types of nuclear facilities. However, this publication references reports that provide such details. This publication provides assistance to those responsible for planning, designing, constructing, operating or decommissioning a nuclear facility. In addition, regulatory organizations and other authorities overseeing nuclear activities or managing nuclear facility licensing processes are often seen as the main source of independent information for the general public; therefore, stakeholder involvement can demonstrate capability and trustworthiness of regulatory organizations as well. The role of stakeholder involvement at different stages of a facility's life cycle is discussed, with suggestions on developing the components of a comprehensive stakeholder involvement plan. Included is guidance on focusing communication with certain stakeholders, applying various

  3. Decommissioning of nuclear facilities involving operations with uranium and thorium

    International Nuclear Information System (INIS)

    Shum, E.Y.; Neuder, S.M.

    1990-01-01

    When a licensed nuclear facility ceases operation, the U.S. Nuclear Regulatory Commission (NRC) ensures that the facility and its site are decontaminated to acceptable levels so they may safely be released for unrestricted public use. Because specific environmental standards or broad federal guidelines governing release of residual radioactive contamination have not been issued, NRC has developed ad hoc cleanup criteria for decommissioning nuclear facilities that involved uranium and thorium. Cleanup criteria include decontamination of buildings, equipment, and land. We will address cleanup criteria and their rationale; procedures for decommissioning uranium/thorium facilities; radiological survey designs and procedures; radiological monitoring and measurement; and cost-effectiveness to demonstrate compliance

  4. Logic model needs for diverse facility types

    International Nuclear Information System (INIS)

    Wilson, J.R.

    1995-01-01

    This paper compares the characteristics of fault trees (where initiators are developed within the fault tree) vs. event trees (where the nodes are developed by fault trees). This comparison requires some additional discussion on the subtlety of initiators. Difficulties when analyzing various reactor-type and processing facilities are discussed to illustrate the particular characteristics of each type of logic. The intent is to allow probabilistic risk assessment (PRA) analysts to be open-quotes bi-logical,close quotes or equally comfortable with event-tree or fault-tree logic, knowing when to apply each

  5. Lining facility for FBR type reactor

    International Nuclear Information System (INIS)

    Shimano, Kunio.

    1991-01-01

    In a lining facility for protecting structural material concretes for concrete buildings in an FBR type power plant, sodium-resistant and heat-resistant first and second coating layers are lined at the surface of concretes, and steam releasing materials are disposed between the first and the second coating layers for releasing water contents evaporated from the concretes to the outside. With such a constitution, since there is no structures for welding steel plates to each other as in the prior art, the fabrication is made easy. Further, since cracks of coating materials can be suppressed, reactor safety is improved. (T.M.)

  6. A successful effort to involve stakeholders in a facility siting decision using LIPS with stakeholder involvement

    International Nuclear Information System (INIS)

    Merkhofer, L.; Conway, R.; Anderson, B.

    1995-01-01

    Local public opposition to federal bureaucratic decisions has resulted in public agencies rethinking the role of stakeholders in decision making. Efforts to include stakeholders directly in the decision-making process are on the increase. Unfortunately, many attempts to involve members of the public in decisions involving complex technical issues have failed. A key problem has been defining a meaningful role for the public in the process of arriving at a technical decision. This paper describes a successful effort by Sandia National Laboratories (SNL) in New Mexico to involve stakeholders in an important technical decision associated with its Environmental Restoration (ER) Project. The decision was where to locate a Corrective Action Management Unit (CAMU), a facility intended to consolidate and store wastes generated from the cleanup of hazardous waste sites. A formal priority setting process known as the Laboratory Integration Prioritization System (LIPS) was adapted to provide an approach for involving the public. Although rarely applied to stakeholder participation, the LIPS process proved surprisingly effective. It produced a consensus over a selected site and enhanced public trust and understanding of Project activities

  7. 41 CFR 102-72.45 - What are the different types of delegations related to facility management?

    Science.gov (United States)

    2010-07-01

    ... different types of delegations related to facility management? The principal types of delegations involved... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are the different types of delegations related to facility management? 102-72.45 Section 102-72.45 Public Contracts and...

  8. Energy efficiency in California laboratory-type facilities

    Energy Technology Data Exchange (ETDEWEB)

    Mills, E.; Bell, G.; Sartor, D. [and others

    1996-07-31

    The central aim of this project is to provide knowledge and tools for increasing the energy efficiency and performance of new and existing laboratory-type facilities in California. We approach the task along three avenues: (1) identification of current energy use and savings potential, (2) development of a {ital Design guide for energy- Efficient Research Laboratories}, and (3) development of a research agenda for focused technology development and improving out understanding of the market. Laboratory-type facilities use a considerable amount of energy resources. They are also important to the local and state economy, and energy costs are a factor in the overall competitiveness of industries utilizing laboratory-type facilities. Although the potential for energy savings is considerable, improving energy efficiency in laboratory-type facilities is no easy task, and there are many formidable barriers to improving energy efficiency in these specialized facilities. Insufficient motivation for individual stake holders to invest in improving energy efficiency using existing technologies as well as conducting related R&D is indicative of the ``public goods`` nature of the opportunity to achieve energy savings in this sector. Due to demanding environmental control requirements and specialized processes, laboratory-type facilities epitomize the important intersection between energy demands in the buildings sector and the industrial sector. Moreover, given the high importance and value of the activities conducted in laboratory-type facilities, they represent one of the most powerful contexts in which energy efficiency improvements stand to yield abundant non-energy benefits if properly applied.

  9. Studies involving proposed waste disposal facilities in Turkey

    International Nuclear Information System (INIS)

    Uslu, I.; Fields, D.E.; Yalcintas, M.G.

    1987-01-01

    Today principal sources of radioactive wastes are hospitals, research institutions, biological research centers, universities, industries and two research reactors in Turkey. These wastes will be treated in a pilot waste treatment facility located in Cekmece Nuclear Research and Training Center, Istanbul. In this temporary waste disposal facility, the wastes will be stored in 200 liter concrete containers until the establishment of the permanent waste disposal sites in Turkey, in 1990. The PRESTO - II (Prediction of Radiation Effects From Shallow Trench Operations) computer code was applied for the general probable sites for LLW disposal in Turkey. The model is non-site specific screening model for assessing radionuclide transport, ensuring exposure, and health impacts to a static local population for a chosen time period, following the end of the disposal operation. The methodology that this codes takes into consideration is versatile and explicitly considers infiltration and percolation of surface water into the trench, leaching of radionuclides, vertical and horizontal transport of radionuclides and use of this contaminated ground water for farming, irrigation, and ingestion

  10. Studies involving proposed waste disposal facilities in Turkey

    International Nuclear Information System (INIS)

    Uslu, I.; Fields, D.E.; Yalcintas, M.G.

    1987-01-01

    The Turkish government is in the process of planning two nuclear reactors in Turkey. The Turkish Atomic Energy Authority has been given the task of developing plans for improved control of low-level wastes (LLW) in Turkey. Principal sources of radioactive wastes are hospitals, research institutions, biological research centers, universities, industries, and two research reactors in Turkey. These wastes will be treated in a pilot water treatment facility located in Cekmece Nuclear Research and Training Center, Istanbul. In this temporary waste disposal facility, the wastes will be stored in 200-l concrete containers until the establishment of the permanent waste disposal sites in Turkey in 1990. The PRESTO-II (prediction of radiation effects from shallow trench operations) computer code has been applied for the general probable sites for LLW disposal in Turkey. The model is intended to serve as a non-site-specific screening model for assessing radionuclide transport, ensuring exposure, and health impacts to a static local population for a chosen time period, following the end of the disposal operation. The methodology that this code takes into consideration is versatile and explicitly considers infiltration and percolation of surface water into the trench, leaching of radionuclides, vertical and horizontal transport of radionuclides, and use of this contaminated ground water for farming, irrigation, and ingestion

  11. Postural control and central motor pathway involvement in type 2 ...

    African Journals Online (AJOL)

    Mona Mokhtar El Bardawil

    2013-04-18

    Apr 18, 2013 ... Postural control and central motor pathway involvement in type 2 .... with a high power 90 mm circular coil, capable of generating. 2 T maximum field ..... advanced glycation end products, oxidative damage and microvascular ...

  12. Tools for Stakeholder Involvement in Facility Management Service Design

    DEFF Research Database (Denmark)

    Nardelli, Giulia; Scupola, Ada

    that are more in line with the stakeholder needs and expectations, and may thus result in increased customer satisfaction, better services and, at the very end, an increased competitive advantage for the organization. Background: The background of this study lies in user involvement in service design...... in the design process as well as FM service provision processes. Research limitations: The major limitation of the study consists of the relatively small amount of interviews conducted, which is the basis for finding the tools in FM service design processes....

  13. Physics and detector simulation facility Type O workstation specifications

    International Nuclear Information System (INIS)

    Chartrand, G.; Cormell, L.R.; Hahn, R.; Jacobson, D.; Johnstad, H.; Leibold, P.; Marquez, M.; Ramsey, B.; Roberts, L.; Scipioni, B.; Yost, G.P.

    1990-11-01

    This document specifies the requirements for the front-end network of workstations of a distributed computing facility. This facility will be needed to perform the physics and detector simulations for the design of Superconducting Super Collider (SSC) detectors, and other computations in support of physics and detector needs. A detailed description of the computer simulation facility is given in the overall system specification document. This document provides revised subsystem specifications for the network of monitor-less Type 0 workstations. The requirements specified in this document supersede the requirements given. In Section 2 a brief functional description of the facility and its use are provided. The list of detailed specifications (vendor requirements) is given in Section 3 and the qualifying requirements (benchmarks) are described in Section 4

  14. Integrals involving functions of the type (WS)sup(q)

    International Nuclear Information System (INIS)

    Srivastava, D.K.

    1981-10-01

    Analytical expressions for integrals involving functions of the Woods-Saxon type raised to the power of q are given. These are expected to be of immediate application in optical model studies and for obtaining various moments of the potential having such shapes. (author)

  15. Identification of Human Intrusion Types into Radwaste Disposal Facility

    International Nuclear Information System (INIS)

    Budi Setiawan

    2007-01-01

    Human intrusion has long been recognized as a potentially important post-closure safety issue for rad waste disposal facility. It is due to the difficulties in predicting future human activities. For the preliminary study of human intrusion, identification of human intrusion types need to be recognized and investigated also the approaching of problem solving must be known to predict the prevention act and accepted risk. (author)

  16. Involvement of family members in life with type 2 diabetes

    DEFF Research Database (Denmark)

    Grabowski, Dan; Andersen, Tue Helms; Varming, Annemarie

    2017-01-01

    OBJECTIVES: Family involvement plays a key role in diabetes management. Problems and challenges related to type 2-diabetes often affect the whole family, and relatives are at increased risk of developing diabetes themselves. We highlight these issues in our objectives: (1) to uncover specific...... family problems associated with mutual involvement in life with type 2-diabetes and (2) to analytically look at ways of approaching these problems in healthcare settings. METHODS: Qualitative data were gathered in participatory problem assessment workshops. The data were analysed in three rounds using...... radical hermeneutics. RESULTS: Problems were categorized in six domains: knowledge, communication, support, everyday life, roles and worries. The final cross-analysis focusing on the link between family identity and healthcare authenticity provided information on how the six domains can be approached...

  17. 78 FR 40519 - Cooper Nuclear Station; Application and Amendment to Facility Operating License Involving...

    Science.gov (United States)

    2013-07-05

    ... NUCLEAR REGULATORY COMMISSION [Docket No. 50-298; NRC-2013-0139] Cooper Nuclear Station; Application and Amendment to Facility Operating License Involving Proposed No Significant Hazards..., issued to Nebraska Public Power District (the licensee), for operation of the Cooper Nuclear Station (CNS...

  18. A study on hazard types occurring in hydrogen facilities

    International Nuclear Information System (INIS)

    Cho, Nam Chul; Jae, Moo Sung; Eon, Yang Joon

    2004-01-01

    Hydrogen has ideal characteristics as an energy carrier. Hydrogen can be used as a clean fuel in a variety of energy end-use sectors including the conversion to electricity. After combustion, it produces only water. Therefore, the concept of hydrogen energy system has attracted much interest worldwide. But hydrogen has a defect that the explosion risk is high to an inflammable gas of a colorless, tasteless and odorless. Therefore, to use the hydrogen to the source of energy, hydrogen accident sequences and causes analysis must be needed. For this, hazard types occurring in hydrogen facilities have been considered through the case of domestic and foreign hydrogen accident in this study and hazard types to be considered are ignition, leaks, hydrogen dispersion, fire an explosion, storage vessel failure, vent and exhaust system, purging, condensation of air, hydrogen embrittlement, physiological hazard, and collisions during transportation

  19. Drug and Alcohol Involvement in Four Types of Fatal Crashes*

    Science.gov (United States)

    Romano, Eduardo; Voas, Robert B.

    2011-01-01

    Objective: The aim of this study was to explore the relationship of drunk and drugged driving to the occurrence of fatal crashes associated with speeding, failure to obey/yield, inattention, and seat belt nonuse. Method: We examined data for fatally injured drivers involved in single-vehicle crashes killed in states in which more than 79% of the drivers were tested for drugs other than alcohol and had a known result. Results: About 25% of the drivers tested positive for drugs, a figure almost double that estimated by the 2007 National Roadside Survey. Cannabinoids and stimulants each contributed to about 23% of the drug-positive results (6% among all fatally injured single-vehicle drivers). Stimulants more than cannabinoids were found to be associated with the four types of crashes under study. Some drugs showed a protective effect over the four crash types under study. Significant interactions between drugs and alcohol were observed. Stimulants contributed to the different types of fatal crashes irrespective of the levels of alcohol consumed by the drivers. Conclusions: This study provides further evidence of a link between drug consumption and fatal crashes. It also opens the door to some interesting and sometimes unexpected questions regarding the way drugs contribute to crashes, which we found varies depending on the type of crash considered, the class of drug, and the presence of alcohol. Research is also needed on drugs that could have a protective effect on the occurrence of fatal crashes. These findings could be highly relevant to the design of drug-related traffic laws and programs targeted at curbing drugged driving. PMID:21683038

  20. Partnership Selection Involving Mixed Types of Uncertain Preferences

    Directory of Open Access Journals (Sweden)

    Li-Ching Ma

    2013-01-01

    Full Text Available Partnership selection is an important issue in management science. This study proposes a general model based on mixed integer programming and goal-programming analytic hierarchy process (GP-AHP to solve partnership selection problems involving mixed types of uncertain or inconsistent preferences. The proposed approach is designed to deal with crisp, interval, step, fuzzy, or mixed comparison preferences, derive crisp priorities, and improve multiple solution problems. The degree of fulfillment of a decision maker’s preferences is also taken into account. The results show that the proposed approach keeps more solution ratios within the given preferred intervals and yields less deviation. In addition, the proposed approach can treat incomplete preference matrices with flexibility in reducing the number of pairwise comparisons required and can also be conveniently developed into a decision support system.

  1. Involvement of the Public Health Authority in emergency planning and preparedness for nuclear facilities in Hungary

    International Nuclear Information System (INIS)

    Sztanyik, L.B.

    1986-01-01

    It is required by the Hungarian Atomic Energy Act and its enacting clause of 1980 that facilities established for the application of atomic energy be designed, constructed and operated in such a manner that abnormal operational occurrences can be avoided and unplanned exposures to radiation and radioactive substances can be prevented. The primary responsibility for planning and implementing emergency actions rests with the management of the operating organization. Thus one of the prerequisites of licensing the first nuclear power plant in Hungary was the preparation and submission for approval of an emergency plan by the operating organization. In addition to this, the council of the county where the power plant is located has also been obliged to prepare a complementary emergency plan, in co-operation with other regional and national authorities, for the prevention of consequences from an emergency that may extend beyond the site boundary of the plant. In preparing the complementary plan, the emergency plan of the facility had to be taken into account. Unlike most national authorities involved in nuclear matters, the Public Health Authority is involved in the preparation of plans for every kind of emergency in a nuclear facility, including even those whose consequences can probably be confined to the plant site. The paper discusses in detail the role and responsibility of the Public Health Authority in emergency planning and preparedness for nuclear facilities. (author)

  2. Intelligent type sodium level gauge and its graduation calibration facility

    International Nuclear Information System (INIS)

    Chen Daolong; Wang Xuan; Li Xinying; Sun Huiqing; Zhu Jie

    1998-04-01

    The component construction and their performances of the intelligent type sodium level gauge newly-developed and its graduation calibration facility are presented. They can be operated in the temperature limit 100∼550 degree C. Its graduation characteristic calibration test is described. The temperature effect is analyzed. The graduation characteristic equation using the medium temperature as the parameter is given. The calibration errors are analyzed. The measurement system using this sodium level gauge is presented. The tests show that the intelligent type sodium level gauge possesses good linearity. The accurate sodium level measurement data can be obtained by means of its on-line compensation function of the temperature effect. Moreover, it possesses the self-inspection, the electric shutoff protection, the setting of full-scale, the thermocouple breaking alarm, the two upper limits and two lower limits alarms, the standard analog output signal and the digital output signal. Therefore, it is applicable particularly to the instrument, control and protection systems of LMFBR. The basic error of this intelligent type sodium level gauge is +-1.9% of measuring range

  3. Cardiac involvement of progressive muscular dystrophy (Becker type, Limb-girdle type and Fukuyama type) evaluated by radionuclide method

    International Nuclear Information System (INIS)

    Nagamachi, Shigeki; Inoue, Kenjiro; Jinnouchi, Seishi; Hoshi, Hiroaki; Ono, Seiji; Ohnishi, Takashi; Futami, Shigemi; Watanabe, Katsushi; Hayashi, Tohru

    1994-01-01

    Tl-201 SPECT and Tc-99m-Human serum albumin (HSA) multigated radionuclide ventriculography were performed on 11 patients with progressive muscular dystrophy (Becker type 2, Fukuyama type 2, Limb-girdle type 7) to evaluate myocardial involvement. Hypoperfusion was detected in 8 patients on Tl-201 SPECT. Decreases in both systolic function (left ventricular ejection fraction; LVEF) and diastolic function (peak filling rate; PFR) were also seen in these patients. A high incidence of myocardial involvement of these kinds of progressive muscular dystrophy was suggested. (author)

  4. Cardiac involvement of progressive muscular dystrophy (Becker type, Limb-girdle type and Fukuyama type) evaluated by radionuclide method

    Energy Technology Data Exchange (ETDEWEB)

    Nagamachi, Shigeki; Inoue, Kenjiro; Jinnouchi, Seishi; Hoshi, Hiroaki; Ono, Seiji; Ohnishi, Takashi; Futami, Shigemi; Watanabe, Katsushi; Hayashi, Tohru [Miyazaki Medical Coll., Kiyotake (Japan)

    1994-02-01

    Tl-201 SPECT and Tc-99m-Human serum albumin (HSA) multigated radionuclide ventriculography were performed on 11 patients with progressive muscular dystrophy (Becker type 2, Fukuyama type 2, Limb-girdle type 7) to evaluate myocardial involvement. Hypoperfusion was detected in 8 patients on Tl-201 SPECT. Decreases in both systolic function (left ventricular ejection fraction; LVEF) and diastolic function (peak filling rate; PFR) were also seen in these patients. A high incidence of myocardial involvement of these kinds of progressive muscular dystrophy was suggested. (author).

  5. Developing Livestock Facility Type Information from USDA Agricultural Census Data for Use in Epidemiological and Economic Models

    Energy Technology Data Exchange (ETDEWEB)

    Melius, C; Robertson, A; Hullinger, P

    2006-10-24

    The epidemiological and economic modeling of livestock diseases requires knowing the size, location, and operational type of each livestock facility within the US. At the present time, the only national database of livestock facilities that is available to the general public is the USDA's 2002 Agricultural Census data, published by the National Agricultural Statistics Service, herein referred to as the 'NASS data.' The NASS data provides facility data at the county level for various livestock types (i.e., beef cows, milk cows, cattle on feed, other cattle, total hogs and pigs, sheep and lambs, milk goats, and angora goats). However, the number and sizes of facilities for the various livestock types are not independent since some facilities have more than one type of livestock, and some livestock are of more than one type (e.g., 'other cattle' that are being fed for slaughter are also 'cattle on feed'). In addition, any data tabulated by NASS that could identify numbers of animals or other data reported by an individual respondent is suppressed by NASS and coded with a 'D.'. To be useful for epidemiological and economic modeling, the NASS data must be converted into a unique set of facility types (farms having similar operational characteristics). The unique set must not double count facilities or animals. At the same time, it must account for all the animals, including those for which the data has been suppressed. Therefore, several data processing steps are required to work back from the published NASS data to obtain a consistent database for individual livestock operations. This technical report documents data processing steps that were used to convert the NASS data into a national livestock facility database with twenty-eight facility types. The process involves two major steps. The first step defines the rules used to estimate the data that is suppressed within the NASS database. The second step converts the NASS

  6. Neuromuscular involvement in various types of Ehlers-Danlos syndrome.

    NARCIS (Netherlands)

    Voermans, N.C.; Alfen, N. van; Pillen, S.; Lammens, M.M.Y.; Schalkwijk, J.; Zwarts, M.J.; Rooij, I.A.L.M. van; Hamel, B.C.J.; Engelen, B.G.M. van

    2009-01-01

    OBJECTIVE: Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin hyperextensibility, and tissue fragility. Muscle involvement is plausible based on recently discovered interactions between

  7. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    International Nuclear Information System (INIS)

    Moore, L.; Shanteau, C.

    1992-12-01

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county's future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County

  8. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Moore, L.; Shanteau, C.

    1992-12-01

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county's future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  9. Final report on the public involvement process phase 1, Monitored Retrievable Storage Facility Feasibility Study

    Energy Technology Data Exchange (ETDEWEB)

    Moore, L.; Shanteau, C.

    1992-12-01

    This report summarizes the pubic involvement component of Phase 1 of the Monitored Retrievable Storage Facility (NM) Feasibility Study in San Juan County, Utah. Part of this summary includes background information on the federal effort to locate a voluntary site for temporary storage of nuclear waste, how San Juan County came to be involved, and a profile of the county. The heart of the report, however, summarizes the activities within the public involvement process, and the issues raised in those various forums. The authors have made every effort to reflect accurately and thoroughly all the concerns and suggestions expressed to us during the five month process. We hope that this report itself is a successful model of partnership with the citizens of the county -- the same kind of partnership the county is seeking to develop with its constituents. Finally, this report offers some suggestions to both county officials and residents alike. These suggestions concern how decision-making about the county`s future can be done by a partnership of informed citizens and listening decision-makers. In the Appendix are materials relating to the public involvement process in San Juan County.

  10. Task types and error types involved in the human-related unplanned reactor trip events

    International Nuclear Information System (INIS)

    Kim, Jae Whan; Park, Jin Kyun

    2008-01-01

    In this paper, the contribution of task types and error types involved in the human-related unplanned reactor trip events that have occurred between 1986 and 2006 in Korean nuclear power plants are analysed in order to establish a strategy for reducing the human-related unplanned reactor trips. Classification systems for the task types, error modes, and cognitive functions are developed or adopted from the currently available taxonomies, and the relevant information is extracted from the event reports or judged on the basis of an event description. According to the analyses from this study, the contributions of the task types are as follows: corrective maintenance (25.7%), planned maintenance (22.8%), planned operation (19.8%), periodic preventive maintenance (14.9%), response to a transient (9.9%), and design/manufacturing/installation (6.9%). According to the analysis of the error modes, error modes such as control failure (22.2%), wrong object (18.5%), omission (14.8%), wrong action (11.1%), and inadequate (8.3%) take up about 75% of the total unplanned trip events. The analysis of the cognitive functions involved in the events indicated that the planning function had the highest contribution (46.7%) to the human actions leading to unplanned reactor trips. This analysis concludes that in order to significantly reduce human-induced or human-related unplanned reactor trips, an aide system (in support of maintenance personnel) for evaluating possible (negative) impacts of planned actions or erroneous actions as well as an appropriate human error prediction technique, should be developed

  11. Task types and error types involved in the human-related unplanned reactor trip events

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Whan; Park, Jin Kyun [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2008-12-15

    In this paper, the contribution of task types and error types involved in the human-related unplanned reactor trip events that have occurred between 1986 and 2006 in Korean nuclear power plants are analysed in order to establish a strategy for reducing the human-related unplanned reactor trips. Classification systems for the task types, error modes, and cognitive functions are developed or adopted from the currently available taxonomies, and the relevant information is extracted from the event reports or judged on the basis of an event description. According to the analyses from this study, the contributions of the task types are as follows: corrective maintenance (25.7%), planned maintenance (22.8%), planned operation (19.8%), periodic preventive maintenance (14.9%), response to a transient (9.9%), and design/manufacturing/installation (6.9%). According to the analysis of the error modes, error modes such as control failure (22.2%), wrong object (18.5%), omission (14.8%), wrong action (11.1%), and inadequate (8.3%) take up about 75% of the total unplanned trip events. The analysis of the cognitive functions involved in the events indicated that the planning function had the highest contribution (46.7%) to the human actions leading to unplanned reactor trips. This analysis concludes that in order to significantly reduce human-induced or human-related unplanned reactor trips, an aide system (in support of maintenance personnel) for evaluating possible (negative) impacts of planned actions or erroneous actions as well as an appropriate human error prediction technique, should be developed.

  12. Developing Poultry Facility Type Information from USDA Agricultural Census Data for Use in Epidemiological and Economic Models

    Energy Technology Data Exchange (ETDEWEB)

    Melius, C

    2007-12-05

    The epidemiological and economic modeling of poultry diseases requires knowing the size, location, and operational type of each poultry type operation within the US. At the present time, the only national database of poultry operations that is available to the general public is the USDA's 2002 Agricultural Census data, published by the National Agricultural Statistics Service, herein referred to as the 'NASS data'. The NASS data provides census data at the county level on poultry operations for various operation types (i.e., layers, broilers, turkeys, ducks, geese). However, the number of farms and sizes of farms for the various types are not independent since some facilities have more than one type of operation. Furthermore, some data on the number of birds represents the number sold, which does not represent the number of birds present at any given time. In addition, any data tabulated by NASS that could identify numbers of birds or other data reported by an individual respondent is suppressed by NASS and coded with a 'D'. To be useful for epidemiological and economic modeling, the NASS data must be converted into a unique set of facility types (farms having similar operational characteristics). The unique set must not double count facilities or birds. At the same time, it must account for all the birds, including those for which the data has been suppressed. Therefore, several data processing steps are required to work back from the published NASS data to obtain a consistent database for individual poultry operations. This technical report documents data processing steps that were used to convert the NASS data into a national poultry facility database with twenty-six facility types (7 egg-laying, 6 broiler, 1 backyard, 3 turkey, and 9 others, representing ducks, geese, ostriches, emus, pigeons, pheasants, quail, game fowl breeders and 'other'). The process involves two major steps. The first step defines the rules used to

  13. Weighted inequalities for Hardy-type operators involving suprema

    Czech Academy of Sciences Publication Activity Database

    Gogatishvili, Amiran; Opic, Bohumír; Pick, L.

    2006-01-01

    Roč. 57, č. 3 (2006), s. 227-255 ISSN 0010-0757 R&D Projects: GA ČR(CZ) GA201/01/0333; GA ČR(CZ) GA201/03/0935 Institutional research plan: CEZ:AV0Z10190503; CEZ:AV0Z10100521 Keywords : Hardy operators involving suprema * weighted inequalities Subject RIV: BA - General Mathematics

  14. The Oskarshamn model for public involvement in the siting of nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    Aahagen, H. [Ahagen and Co (Sweden); CarIsson, Torsten [Mayor, Oskarshamn (Sweden); Hallberg, K. [Local Competence Building, Oskarshamn (Sweden); Andersson, Kjell [Karinta-Konsult, Taeby(Sweden)

    1999-12-01

    The Oskarshamn model has so far worked extremely well as a tool to achieve openness and public participation. The municipality involvement has been successful in several aspects, e.g.: It has been possible to influence the program, to a large extent, to meet certain municipality conditions and to ensure the local perspective. The local competence has increased to a considerable degree. The activities generated by the six working groups with a total of 40 members have generated a large number of contacts with various organisations, schools, mass media, individuals in the general public and interest groups. For the future, clarification of the disposal method and site selection criteria as well as the site selection process as such is crucial. The municipality has also emphasised the importance of SKB having shown the integration between site selection criteria, the feasibility study and the safety assessment. Furthermore, the programs for the encapsulation facility and the repository must be co-ordinated. For Oskarshamn it will be of utmost importance that the repository is well under way to be realised before the encapsulation facility can be built.

  15. The Oskarshamn model for public involvement in the siting of nuclear facilities

    International Nuclear Information System (INIS)

    Aahagen, H.; CarIsson, Torsten; Hallberg, K.; Andersson, Kjell

    1999-01-01

    The Oskarshamn model has so far worked extremely well as a tool to achieve openness and public participation. The municipality involvement has been successful in several aspects, e.g.: It has been possible to influence the program, to a large extent, to meet certain municipality conditions and to ensure the local perspective. The local competence has increased to a considerable degree. The activities generated by the six working groups with a total of 40 members have generated a large number of contacts with various organisations, schools, mass media, individuals in the general public and interest groups. For the future, clarification of the disposal method and site selection criteria as well as the site selection process as such is crucial. The municipality has also emphasised the importance of SKB having shown the integration between site selection criteria, the feasibility study and the safety assessment. Furthermore, the programs for the encapsulation facility and the repository must be co-ordinated. For Oskarshamn it will be of utmost importance that the repository is well under way to be realised before the encapsulation facility can be built

  16. Postural control and central motor pathway involvement in type 2 ...

    African Journals Online (AJOL)

    Logistic regression analysis showed peripheral neuropathy as the main factor implicated in postural instability in these patients. However, significant correlation was found between MEP amplitude and MCT composite score in patients without peripheral neuropathy. Conclusion: Although type 2 diabetic patients had ...

  17. On Hadamard-Type Inequalities Involving Several Kinds of Convexity

    Directory of Open Access Journals (Sweden)

    Dragomir SeverS

    2010-01-01

    Full Text Available We do not only give the extensions of the results given by Gill et al. (1997 for log-convex functions but also obtain some new Hadamard-type inequalities for log-convex -convex, and -convex functions.

  18. Stakeholder issues and involvement in decommissioning nuclear facilities. Lessons learnt from WPDD and FSC activities and documentation

    International Nuclear Information System (INIS)

    Pescatore, Claudio; Vari, Anna; Mays, C.; O'Sullivan, P.

    2007-01-01

    , there is a need to consider also views of stakeholders that represent national interests. As the decision process moves from issues concerned with the shutdown of the plant to strategies for its dismantling, the importance of purely local interests becomes greater. For this reason, it is necessary to develop dialogue and cooperation among regulators, implementers, and local stakeholders as early as practicable. The host municipalities for nuclear facilities tend to focus their attention on the day-to-day issues arising from the activities at the plant and, as regards decommissioning, will generally favour the early reuse of the site for economic or cultural purposes. As in other phases of the nuclear facility life cycle, it is necessary to develop trust among stakeholders in decommissioning and dismantling projects. This may be accomplished through involving local and regional actors in decision-making, but also in monitoring activities, so as to have a better grip on the continuous changes taking place at the site. Transparency is needed in decision-making and in the respective roles played by regulators, implementers and local authorities. At all times, proactive information, and efforts to 'translate' technical information into language meaningful to the chosen audience, will contribute to building mutual understanding and trust. Partnership arrangements, by which institutions enter into structured project-management relationships with local communities, have been found beneficial. Decommissioning in both nuclear and non-nuclear areas may be viewed as an opportunity to improve the sustainability of the host community. The creation of added cultural or economic value can contribute to increasing quality of life over the years. More recent designs integrating reflection on the end use of the facility and site, or technical provisions for quick transitions to other types of facilities, provide better assurance to the host community that there will be

  19. Involving the public in decision-making at federal facilities: The Department of Energy experience

    International Nuclear Information System (INIS)

    Gesalman, C.M.

    1996-01-01

    The Department of Energy is involved in cleanup of a wide variety of sites used in the development and production of nuclear weapons. Substantial and increasing efforts have been made to involve the public in the planning and implementation of the cleanup projects. Early in the program, public participation was mainly an information transfer effort. More recently, innovative techniques have been used to increase public understanding of the tradeoffs required in making cleanup decisions (e.g., more stringent cleanup standards lead to higher costs). Sites now realize that relationships are key and are working to develop them. Advisory boards have been established at several sites. The methods of forming the boards have varied from site to site, as have the size of the group and the issues addressed. The effectiveness of the boards in their goal of improving public participation at the sites will be evaluated in the next fiscal year. DOE has sought public input on an increasing number of issues, such as future use of its facilities, environmental justice concerns, and budget development. Assumptions about future use of sites are crucial to setting realistic cleanup standards and controlling costs. Decisions made in the early phases of the budget process are now based in part on stakeholder input regarding priorities; for example, stakeholder concerns about and support for emphasizing plutonium cleanup at Rocky Flats have led to changes in priorities between the materials stabilization and environmental restoration programs. Environmental justice has become an increasing issue; sites must ensure that public participation programs effectively reach minority and low-income populations

  20. 77 FR 33243 - Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving...

    Science.gov (United States)

    2012-06-05

    ... expansion process, thermal expansion mismatch between the tube and tubesheet, and from the differential... NUCLEAR REGULATORY COMMISSION [NRC-2012-0125] Applications and Amendments to Facility Operating...

  1. Characterization of uranium corrosion products involved in the March 13, 1998 fuel manufacturing facility pyrophoric event

    International Nuclear Information System (INIS)

    Totemeier, T.C.

    1999-01-01

    Uranium metal corrosion products from ZPPR fuel plates involved in the March 13, 1998 pyrophoric event in the Fuel Manufacturing Facility at Argonne National Laboratory-West were characterized using thermo-gravimetric analysis, X-ray diffraction, and BET gas sorption techniques. Characterization was performed on corrosion products in several different conditions: immediately after separation from the source metal, after low-temperature passivation, after passivation and extended vault storage, and after burning in the pyrophoric event. The ignition temperatures and hydride fractions of the corrosion product were strongly dependent on corrosion extent. Corrosion products from plates with corrosion extents less than 0.7% did not ignite in TGA testing, while products from plates with corrosion extents greater than 1.2% consistently ignited. Corrosion extent is defined as mass of corrosion products divided by the total mass of uranium. The hydride fraction increased with corrosion extent. There was little change in corrosion product properties after low-temperature passivation or vault storage. The burned products were not reactive and contained no hydride; the principal constituents were UO 2 and U 3 O 7 . The source of the event was a considerable quantity of reactive hydride present in the corrosion products. No specific ignition mechanism could be conclusively identified. The most likely initiator was a static discharge in the corrosion product from the 14th can as it was poured into the consolidation can. The available evidence does not support scenarios in which the powder in the consolidation can slowly self-heated to the ignition point, or in which the powder in the 14th can was improperly passivated

  2. Characterization of uranium corrosion products involved in the March 13, 1998 fuel manufacturing facility pyrophoric event.

    Energy Technology Data Exchange (ETDEWEB)

    Totemeier, T.C.

    1999-04-26

    Uranium metal corrosion products from ZPPR fuel plates involved in the March 13, 1998 pyrophoric event in the Fuel Manufacturing Facility at Argonne National Laboratory-West were characterized using thermo-gravimetric analysis, X-ray diffraction, and BET gas sorption techniques. Characterization was performed on corrosion products in several different conditions: immediately after separation from the source metal, after low-temperature passivation, after passivation and extended vault storage, and after burning in the pyrophoric event. The ignition temperatures and hydride fractions of the corrosion product were strongly dependent on corrosion extent. Corrosion products from plates with corrosion extents less than 0.7% did not ignite in TGA testing, while products from plates with corrosion extents greater than 1.2% consistently ignited. Corrosion extent is defined as mass of corrosion products divided by the total mass of uranium. The hydride fraction increased with corrosion extent. There was little change in corrosion product properties after low-temperature passivation or vault storage. The burned products were not reactive and contained no hydride; the principal constituents were UO{sub 2} and U{sub 3}O{sub 7}. The source of the event was a considerable quantity of reactive hydride present in the corrosion products. No specific ignition mechanism could be conclusively identified. The most likely initiator was a static discharge in the corrosion product from the 14th can as it was poured into the consolidation can. The available evidence does not support scenarios in which the powder in the consolidation can slowly self-heated to the ignition point, or in which the powder in the 14th can was improperly passivated.

  3. The role of public involvement in managing political conflict: A comparative case study of public involvement activities in siting low-level radioactive waste disposal facilities

    International Nuclear Information System (INIS)

    Tzoumis, K.A.

    1992-01-01

    A model of political conflict based on the components of scope, intensity and visibility is used to rank the degree of conflict for states hosting a low-level radioactive waste facility in the US. Data were gathered from sixty-five telephone interviews and comparisons made with ten national experts. Public involvement and compensation packages (reviewed in Chapter IV) to be potential conflict management tools for practitioners. The role of the governor and the complexity of the siting process are two additional factors that are important in escalating a conflict. Technical factors of complexity and source of the waste along with the past performance of the company handling the facility have no link to conflict. Conflict escalation is proposed as a means towards understanding the agenda-building process

  4. Investigation on proper materials of a liner system for trench type disposal facilities of radioactive wastes from research, industrial and medical facilities

    International Nuclear Information System (INIS)

    Nakata, Hisakazu; Amazawa, Hiroya; Sakai, Akihiro; Arikawa, Masanobu; Sakamoto, Yoshiaki

    2011-08-01

    The Low-level Radioactive Waste Disposal Project Center of Japan Atomic Energy Agency will settle on near surface disposal facilities with and without engineered barriers for radioactive wastes from research, industrial and medical facilities. Both of them are so called 'concrete pit type' and 'trench type', respectively. The technical standard of constructing and operating a disposal facility based on 'Law for the Regulations of Nuclear Source Material, Nuclear Fuel Material and Reactors' have been regulated partly by referring to that of 'Waste Management and Public Cleansing Law'. This means that the concrete pit type and the trench type disposal facility resemble an isolated type for specified industrial wastes and a non leachate controlled type final disposal site for stable industrial wastes, respectively. On the other, We plan to design a disposal facility with a liner system corresponding to a leachate controlled type final disposal site on a crucial assumption that radioactive wastes other than stable industrial wastes to be disposed into the trench type disposal facility is generated. By current nuclear related regulations in Japan, There are no technical standard of constructing the disposal facility with the liner system referring to that of 'Waste Management and Public Cleansing Law'. We investigate the function of the liner system in order to design a proper liner system for the trench type disposal facility. In this report, We investigated liner materials currently in use by actual leachate controlled type final disposal sites in Japan. Thereby important items such as tensile strength, durability from a view point of selecting proper liner materials were studied. The items were classified into three categories according to importance. We ranked proper liner materials for the trench type disposal facility by evaluating the important items per material. As a result, high density polyethylene(HDPE) of high elasticity type polymetric sheet was selected

  5. Aqueous Boric acid injection facility of PWR type reactor

    International Nuclear Information System (INIS)

    Matsuoka, Tsuyoshi; Iwami, Masao.

    1996-01-01

    If a rupture should be caused in a secondary system of a PWR type reactor, pressure of a primary coolant recycling system is lowered, and a back flow check valve is opened in response to the lowering of the pressure. Then, low temperature aqueous boric acid in the lower portion of a pressurized tank is flown into the primary coolant recycling system based on the pressure difference, and the aqueous boric acid reaches the reactor core together with coolants to suppress reactivity. If the injection is continued, high temperature aqueous boric acid in the upper portion boils under a reduced pressure, further urges the low temperature aqueous boric acid in the lower portion by the steam pressure and injects the same to the primary system. The aqueous boric acid stream from the pressurized tank flowing by self evaporation of the high temperature aqueous boric acid itself is rectified by a rectifying device to prevent occurrence of vortex flow, and the steam is injected in a state of uniform stream. When the pressure in the pressurized tank is lowered, a bypass valve is opened to introduce the high pressure fluid of primary system into the pressurized tank to keep the pressure to a predetermined value. When the pressure in the pressurized tank is elevated to higher than the pressure of the primary system, a back flow check valve is opened, and high pressure aqueous boric acid is flown out of the pressurized tank to keep the pressure to a predetermined value. (N.H.)

  6. Is Male Involvement in ANC and PMTCT Associated with Increased Facility-Based Obstetric Delivery in Pregnant Women?

    Science.gov (United States)

    Kashitala, Joshua; Nyambe, Namakau; Mwalo, Stuart; Musamba, Josephine; Chishinga, Nathaniel; Kasonde, Prisca; Lilja, Anna M; Mwiche, Angel; Welsh, Michael

    2015-06-01

    Ensuring that pregnant women are delivering in a health facility and are attended to by skilled birth attendants is critical to reducing maternal and infant morbidity and mortality. This study sought to determine the associations between male involvement in antenatal care (ANC) services and pregnant women delivering at health facilities and being attended to by skilled birth attendants as well as attending postnatal care. This was a retrospective cohort study using secondary analysis of program data. We reviewed health records of all pregnant women who attended antenatal services irrespective of HIV status between March and December 2012 in 10 health facilities in three provinces of Zambia. An extraction questionnaire was used to collect sociodemographic and clinical information from registers used in services for maternal neonatal child health as well as delivery. Using logistic regression, we calculated the odds ratios (OR) and 95% confidence intervals (CI) of the association between (1) male involvement and delivery at a health facility by a skilled birth attendant and (2) male involvement and women's attendance at postnatal services. We found that more women who had been accompanied by their male partner during ANC delivered at a health facility than those who had not been accompanied (88/220 = 40% vs. 543/1787 = 30.4%, respectively; OR 1.53, 95% CI: 1.15-2.04). Also, we noted that a greater proportion of the women who returned for postnatal visits had been accompanied by their partner at ANC visits, compared to those women who came to ANC without their partner (106/220 = 48.2% vs. 661/1787 = 37.0%, respectively; OR 1.58, 95% CI: 1.20-2.10). Male involvement seems to be a key factor in women's health-seeking behaviours and could have a positive impact on maternal and infant morbidity and mortality.

  7. Environmental consequences of hydroelectric development: the role of facility size and type

    International Nuclear Information System (INIS)

    Gleick, P.H.

    1992-01-01

    The development of hydroelectric power throughout the world is receiving renewed attention as the economic, political, and environmental costs of conventional energy production rise. There is currently a perception that hydroelectricity has environmental and economic advantages over electricity produced by conventional energy technologies, but there is a paucity of information about the environmental impacts of hydroelectric facilities as a function of size and type. We characterize the environmental impacts of hydroelectric developments and quantify these impacts as a function of the size and type of project. Several unexpected conclusions arise from our analysis. For most hydroelectric facilities, size, as measured by installed capacity, is not necessarily a good indicator or the severity of environmental costs. For impacts such as land flooded and evaporative water lost, smaller facilities cause greater environmental disruptions per unit of energy produced than do larger facilities. (Author)

  8. Efficiency improvement of the investment and innovation activities in the transport facility construction field with public-private partnership involvement

    Science.gov (United States)

    Shibayeva, Marina; Serebryakova, Yelena; Shalnev, Oleg

    2017-10-01

    Growing demand to increase the investment volume in modernization and development projects for transport infrastructure define the urgency of the current study. The amount of private sector investments in the field is insufficient to implement the projects for road construction due to their significant capital intensity and long payoff period. The implementation of social significant infrastructure projects on the principles of public-private partnership is one of the key strategic directions of growth for transport facilities. The authors come up with a concept and methodology for modeling the investment and innovation activity in the transport facility construction. Furthermore, there is developed a model to find the balance between public and private sector investments in implementing construction projects for transport infrastructure with involvement of PPP (further - public-private partnership). The suggested concepts aim to improve the efficiency rate of the investment and innovation activity in the field of transport facility construction on the basis of public and private sectors collaboration.

  9. 76 FR 73727 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-11-29

    ..., Donald C. Cook Nuclear Plant, Unit 2 (DCCNP-2), Berrien County, Michigan; Date of amendment request... Counsel, Indiana Michigan Power Company, One Cook Place, Bridgman, MI 49106. NRC Acting Branch Chief: Thomas J. Wengert. Notice of Issuance of Amendments to Facility Operating Licenses During the period...

  10. Household Consumption of Food-Away-From-Home: Total Expenditure and by Type of Food Facility

    OpenAIRE

    Vicki A. McCracken; Jon A. Brandt

    1987-01-01

    Consistent with prior expectations based on household production theory, household income, time value, size and composition, and the environment in which production and consumption occurred were all important determinants of total household expenditures on food-away-from-home. However, the importance of these factors varied by type of food facility: conventional restaurants, fast-food facilities, and other commercial establishments. Decomposition of the tobit elasticities indicated the differ...

  11. RADON-type disposal facility safety case for the co-ordinated research project on improvement of safety assessment methodologies for near surface radioactive waste disposal facilities (ISAM)

    International Nuclear Information System (INIS)

    Guskov, A.; Batanjieva, B.; Kozak, M.W.; Torres-Vidal, C.

    2002-01-01

    The ISAM safety assessment methodology was applied to RADON-type facilities. The assessments conducted through the ISAM project were among the first conducted for these kinds of facilities. These assessments are anticipated to lead to significantly improved levels of safety in countries with such facilities. Experience gained though this RADON-type Safety Case was already used in Russia while developing national regulatory documents. (author)

  12. Disordered gambling, type of gambling and gambling involvement in the British Gambling Prevalence Survey 2007

    OpenAIRE

    LaPlante, Debi A.; Nelson, Sarah E.; LaBrie, Richard A.; Shaffer, Howard J.

    2009-01-01

    Background: The purpose of this study was to examine the relationships between types of gambling and disordered gambling, with and without controlling for gambling involvement (i.e. the number of types of games with which respondents were involved during the past 12 months). Methods: We completed a secondary data analysis of the 2007 British Gambling Prevalence Survey (BGPS), which collected data in England, Scotland and Wales between September 2006 and March 2007. The sample included 9003 re...

  13. Simulation of natural circulation on an integral type experimental facility, MASLWR

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Youngjong; Lim, Sungwon; Ha, Jaejoo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-05-15

    The OSU MASLWR test facility was reconfigured to eliminate a recurring grounding problem and improve facility reliability in anticipation of conducting an IAEA International Collaborative Standard Problem (ICSP). The purpose of ICSP is to provide experimental data on flow instability phenomena under natural circulation conditions and coupled containment/reactor vessel behavior in integral-type reactors, and to evaluate system code capabilities to predict natural circulation phenomena for integral type PWR, by simulating an integrated experiment. A natural circulation in the primary side during various core powers is analyzed using TASS/SMR code for the integral type experimental facility. The calculation results show higher steady state primary flow than experiment. If it matches the initial flow with experiment, it shows lower primary flow than experiment according to the increase of power. The code predictions may be improved by applying a Reynolds number dependent form loss coefficient to accurately account for unrecoverable pressure losses.

  14. Radioactive waste storage facilities, involvement of AVN in inspection and safety assessment

    International Nuclear Information System (INIS)

    Simenon, R.; Smidts, O.

    2006-01-01

    The legislative and regulatory framework in Belgium for the licensing and the operation of radioactive waste storage buildings are defined by the Royal Decree of 20 July 2001 (hereby providing the general regulations regarding to the protection of the population, the workers and the environment against the dangers of ionising radiation). This RD introduces in the Belgian law the radiological protection and ALARA-policy concepts. The licence of each nuclear facility takes the form of a Royal Decree of Authorization. It stipulates that the plant has to be in conformity with its Safety Analysis Report. This report is however not a public document but is legally binding. Up to now, the safety assessment for radioactive waste storage facilities, which is implemented in this Safety Analysis Report, has been judged on a case-by-case basis. AVN is an authorized inspection organisation to carry out the surveillance of the Belgian nuclear installations and performs hereby nuclear safety assessments. AVN has a role in the nuclear safety and radiation protection during all the phases of a nuclear facility: issuance of licenses, during design and construction phase, operation (including reviewing and formal approval of modifications) and finally the decommissioning. Permanent inspections are performed on a regular basis by AVN, this by a dedicated site inspector, who is responsible for a site of an operator with nuclear facilities. Besides the day-to-day inspections during operation there are also the periodic safety reviews. AVN assesses the methodological approaches for the analyses, reviews and approves the final studies and results. The conditioned waste in Belgium is stored on the Belgoprocess' sites (region Mol-Dessel) for an intermediate period (about 80 years). In the meantime, a well-defined inspection programme is being implemented to ensure that the conditioned waste continues to be stored safely during this temporary storage period. This programme was draw up by

  15. Progression of cardiac involvement in patients with limb-girdle type 2 and Becker muscular dystrophies

    DEFF Research Database (Denmark)

    Petri, Helle; Sveen, Marie-Louise; Thune, Jens Jakob

    2015-01-01

    AIM: To assess the degree and progression of cardiac involvement in patients with limb-girdle type 2 (LGMD2) and Becker muscular dystrophies (BMD). METHODS: A follow-up study of 100 LGMD2 (types A-L) and 30 BMD patients assessed by electrocardiogram (ECG) and echocardiography, supplemented...

  16. Staff's reactions towards partnered sexual expressions involving people with dementia living in long-term care facilities.

    Science.gov (United States)

    Villar, Feliciano; Celdrán, Montserrat; Serrat, Rodrigo; Fabà, Josep; Martínez, Teresa

    2018-05-01

    To explore staff responses, in terms of common practices, towards partnered sexual relationships in long-term care facilities where one or both people involved have dementia. It also tries to determine personal and institutional factors influencing these responses. Although some studies, mostly qualitative, have focused on reactions to residents' sexual expressions so far the issue has not been assessed in a study using large and diverse samples. Cross-sectional quantitative study using vignette technique. Participants were 2,295 staff members at 152 Spanish long-term care facilities. Data were collected during 2016. A vignette describing sexual situations involving people with dementia was presented to participants. After the vignette, participants had to answer the question: "What do you think most of your colleagues would do in this situation?" with nine possible responses. Results showed that relationships involving persons with dementia were perceived as potentially problematic by staff. In both conditions, discussing the case with a colleague or supervisor was the most frequently chosen reaction. More restrictive reactions were mentioned when only one person with dementia was involved in the relationship. Factors such as participants" age and years of experience, professional post and commitment to person-centred care practices were related with the frequency of common restriction practices. Results highlight the importance of providing staff with clear guidelines regarding the management of specific sexual situations to avoid stereotyped restrictive reactions. © 2017 John Wiley & Sons Ltd.

  17. User involvement in structured violence risk management within forensic mental health facilities -- a systematic literature review.

    Science.gov (United States)

    Eidhammer, Gunnar; Fluttert, Frans A J; Bjørkly, Stål

    2014-10-01

    To examine empirical literature on user involvement in collaboration between patients and nurses. The scope of the review was limited to structured violence risk management interventions in forensic mental health settings. Violence in forensic mental health settings represents a significant problem for patients and staff. Structured violence risk management interventions in forensic mental health have been reported to ignore patient participation, despite the growing attention on user involvement in clinical practice. A systematic review. Searches were conducted in six databases: the Cochrane Systematic Reviews, MEDLINE, CINAHL, ProQuest, ScienceDirect and PsycINFO. Papers were assessed according to a predetermined set of inclusion and exclusion criteria. After searches of the reference lists of retrieved articles were conducted, only three papers met the inclusion criteria. This review has shown that empirical research on the topic of risk management interventions in which patients are involved is scarce. There is barely any research evidence of the clinical effect of user involvement approaches on violence risk management in forensic mental health practice. Therefore, we suggest that clinicians may learn from positive experiences concerning user involvement in general psychiatry and carefully adapt and test them out in the forensic treatment context. © 2014 John Wiley & Sons Ltd.

  18. Workers' exposure to bioaerosols from three different types of composting facilities.

    Science.gov (United States)

    Bonifait, Laetitia; Marchand, Geneviève; Veillette, Marc; M'Bareche, Hamza; Dubuis, Marie-Eve; Pépin, Carole; Cloutier, Yves; Bernard, Yves; Duchaine, Caroline

    2017-10-01

    Composting is a natural dynamic biological process used to valorise putrescible organic matter. The composting process can involve vigorous movements of waste material piles, which release high concentrations of bioaerosols into the surrounding environment. There is a lack of knowledge concerning the dispersal of airborne microorganisms emitted by composting plants (CP) as well as the potential occupational exposure of composting workers. The aim of this study was to investigate the workers exposure to bioaerosols during working activities in three different types of composting facilities (domestic, manure, carcass) using two different quantification methods (cultivation and qPCR) for bacteria and moulds concentrations. As expected, even if there are differences between all CP frameworks, independently of the type of the raw compost used, the production of bioaerosols increases significantly during handling activities. Important concentrations of mesophilic moulds and mesophilic bacteria were noted in the working areas with a respective maximal concentration of 2.3 × 10 5 CFU/m 3 and 1.6 × 10 5 CFU/m 3 . A. fumigatus and thermophilic Actinomycetes were also detected in all working areas for the 3 CP. This study emphases the risks for workers to being in contact with aerosolized pathogens such as Mycobacterium and Legionella and more specifically, L. pneumophila. The presence of high concentration of these bacteria in CP suggests a potential occupational health risk. This study may lead to recommendations for the creation of limits for occupational exposure. There is a need for identifying the standards exposure limits to bioaerosols in CP and efficient recommendation for a better protection of workers' health.

  19. MR imaging of abdominopelvic involvement in neurofibromatosis type 1: a review of 43 patients

    Energy Technology Data Exchange (ETDEWEB)

    Zacharia, T. Thomas [Massachusetts General Hospital, Department of Radiology, Boston, MA (United States); Jaramillo, Diego [Children' s Hospital of Philadelphia, Department of Radiology, Philadelphia, PA (United States); Poussaint, Tina Young [Children' s Hospital Boston, Department of Radiology, Boston, MA (United States); Korf, Bruce [University of Alabama at Birmingham Hospital, Department of Genetics, Birmingham, AL (United States)

    2005-03-01

    Plexiform neurofibromas are a frequent complication of neurofibromatosis type 1. This article discusses MR imaging findings and distribution of plexiform neurofibromas in the abdomen and pelvis. To define the most prevalent patterns of involvement and MR imaging findings in abdominopelvic neurofibromatosis type 1. We reviewed the MR appearance of abdominopelvic lesions in 23 male and 20 female patients (median age: 16 years) with type 1 neurofibromatosis. The patients were part of a multi-institutional study of 300 patients. Imaging included coronal or sagittal, and axial short tau inversion recovery images. The most common abdominopelvic involvement was in the abdominopelvic wall (n=28, 65%) and lumbosacral plexus (n=27, 63%). Retroperitoneal involvement was frequent (n=15, 35%). Lesions were less often intraperitoneal (21%) (P=0.001). Pelvic disease (n=27, 63%), neural canal involvement (n=18, 42%), and hydronephrosis (n=4, 9%) were also noted. Target-like appearance of plexiform lesions was noted in more than half the patients. Abdominopelvic involvement in neurofibromatosis type 1 is primarily extraperitoneal. Although lesions are most prevalent in the abdominopelvic wall and lumbosacral plexus, retroperitoneal and pelvic involvement is common and usually affects important organs. MR imaging added information in the initial and follow-up clinical evaluation of these patients. (orig.)

  20. Type A aortic dissection: Are there CT signs suggestive of valvular involvement?

    Energy Technology Data Exchange (ETDEWEB)

    Platon, Alexandra, E-mail: alexandra.platon@hcuge.ch [Department of Radiology, Emergency Radiology Unit, University Hospital of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva (Switzerland); Bernard, Stephane; Perrin, Nils [Department of Radiology, Emergency Radiology Unit, University Hospital of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva (Switzerland); Murith, Nicolas [Division of Cardiovascular Surgery, University Hospital of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva (Switzerland); John, Gregor [Department of Internal medicine/Geriatrics and Rehabilitation, University Hospital of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva (Switzerland); Department of Internal Medicine, Hôpital neuchâtelois, 2300 La Chaux-de-Fonds (Switzerland); Perneger, Thomas [Division of Clinical Epidemiology, University Hospital of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva (Switzerland); Rutschmann, Olivier T. [Division of Emergency Medicine, University Hospitals of Geneva and School of Medicine, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva (Switzerland); Poletti, Pierre-Alexandre [Department of Radiology, Emergency Radiology Unit, University Hospital of Geneva, 4 rue Gabrielle-Perret-Gentil, 1211, Geneva (Switzerland)

    2016-11-15

    Highlights: • Non-ECG gated CT rarely shows valve involvement in type A aortic dissection. • Diameters of the aortic root in type A aortic dissection were measured on initial CT. • Sinus of Valsalva diameter >45 mm is 100% specific to predict aortic valve involvement. - Abstract: Aim: To identify the predictive signs of aortic valve involvement on the non-electrocardiogram (ECG)-gated admission computed tomography (CT) of patients with Type A aortic dissection (AD) according to the Stanford classification. Materials and methods: We retrospectively analyzed the non-ECG-gated CT examinations of patients admitted to the emergency department who underwent surgery for Type A AD over a period of 4 years. The diameter of the following structures was calculated as the mean of the smallest and largest diameters (mm) measured in two different planes: aortic annulus, sinus of Valsalva, sinotubular junction, and proximal ascending aorta. These parameters were compared against operative reports in order to determine whether they were predictive of aortic valve involvement. Results: In total, 20 patients (13 men and 7 women) of a mean age of 59.5 years (29–80) were included, 55% of patients (11/20) having surgically proven valvular involvement. The mean diameters (in mm) of the aortic annulus, sinus of Valsalva, sinotubular junction and proximal ascending aorta in the group with (and without, respectively) valvular involvement was 27.7 (26.7), 44.3 (38.1), 42.6 (36.6), and 47.8 (45.9). Only the measurement of the mean diameter of the sinuses of Valsalva was significantly predictive (p = 0.02) of aortic valve involvement. Conclusion: Our findings suggest that measuring the diameter of the sinuses of Valsalva on non-ECG-gated admission CT examinations allows for predicting aortic valve involvement in Type A AD patients.

  1. Type A aortic dissection: Are there CT signs suggestive of valvular involvement?

    International Nuclear Information System (INIS)

    Platon, Alexandra; Bernard, Stephane; Perrin, Nils; Murith, Nicolas; John, Gregor; Perneger, Thomas; Rutschmann, Olivier T.; Poletti, Pierre-Alexandre

    2016-01-01

    Highlights: • Non-ECG gated CT rarely shows valve involvement in type A aortic dissection. • Diameters of the aortic root in type A aortic dissection were measured on initial CT. • Sinus of Valsalva diameter >45 mm is 100% specific to predict aortic valve involvement. - Abstract: Aim: To identify the predictive signs of aortic valve involvement on the non-electrocardiogram (ECG)-gated admission computed tomography (CT) of patients with Type A aortic dissection (AD) according to the Stanford classification. Materials and methods: We retrospectively analyzed the non-ECG-gated CT examinations of patients admitted to the emergency department who underwent surgery for Type A AD over a period of 4 years. The diameter of the following structures was calculated as the mean of the smallest and largest diameters (mm) measured in two different planes: aortic annulus, sinus of Valsalva, sinotubular junction, and proximal ascending aorta. These parameters were compared against operative reports in order to determine whether they were predictive of aortic valve involvement. Results: In total, 20 patients (13 men and 7 women) of a mean age of 59.5 years (29–80) were included, 55% of patients (11/20) having surgically proven valvular involvement. The mean diameters (in mm) of the aortic annulus, sinus of Valsalva, sinotubular junction and proximal ascending aorta in the group with (and without, respectively) valvular involvement was 27.7 (26.7), 44.3 (38.1), 42.6 (36.6), and 47.8 (45.9). Only the measurement of the mean diameter of the sinuses of Valsalva was significantly predictive (p = 0.02) of aortic valve involvement. Conclusion: Our findings suggest that measuring the diameter of the sinuses of Valsalva on non-ECG-gated admission CT examinations allows for predicting aortic valve involvement in Type A AD patients.

  2. 78 FR 21164 - Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving...

    Science.gov (United States)

    2013-04-09

    ... identification (ID) certificate, which allows the participant (or its counsel or representative) to digitally... safety-related equipment lineup. However, this modification and new line up does not result in a new type...

  3. Three formulations of the multi-type capacitated facility location problem

    DEFF Research Database (Denmark)

    Klose, Andreas

    The "multi-type" or "modular" capacitated facility location problem is a discrete location model that addresses non-convex piecewise linear production costs as, for instance, staircase cost functions. The literature basically distinguishes three different ways to formulate non-convex piecewise...

  4. Cavity-Type BPMs For The TESLA Test Facility Free Electron Laser

    CERN Document Server

    Waldmann, H

    2003-01-01

    For measurements of the beam position at the undulator section of the TESLA Test Facility (TTF) at DESY cavity-type beam position monitors were developed, installed and brought into operation. Besides of some theoretical aspects results of in-beam measurements at the TTF are presented and pros and cons of this monitor concept are discussed.

  5. Types of parental involvement in CBT with anxious youth: a preliminary meta-analysis.

    Science.gov (United States)

    Manassis, Katharina; Lee, Trevor Changgun; Bennett, Kathryn; Zhao, Xiu Yan; Mendlowitz, Sandra; Duda, Stephanie; Saini, Michael; Wilansky, Pamela; Baer, Susan; Barrett, Paula; Bodden, Denise; Cobham, Vanessa E; Dadds, Mark R; Flannery-Schroeder, Ellen; Ginsburg, Golda; Heyne, David; Hudson, Jennifer L; Kendall, Philip C; Liber, Juliette; Masia-Warner, Carrie; Nauta, Maaike H; Rapee, Ronald M; Silverman, Wendy; Siqueland, Lynne; Spence, Susan H; Utens, Elisabeth; Wood, Jeffrey J

    2014-12-01

    Meta-analytic studies have not confirmed that involving parents in cognitive behavior therapy (CBT) for anxious children is therapeutically beneficial. There is also great heterogeneity in the type of parental involvement included. We investigated parental involvement focused on contingency management (CM) and transfer of control (TC) as a potential outcome moderator using a meta-analysis with individual patient data. Investigators of randomized controlled trials (RCTs) of CBT for anxious children, identified systematically, were invited to submit their data. Conditions in each RCT were coded based on type of parental involvement in CBT (i.e., low involvement, active involvement without emphasis on CM or TC, active involvement with emphasis on CM or TC). Treatment outcomes were compared using a 1-stage meta-analysis. All cases involved in active treatment (894 of 1,618) were included for subgroup analyses. Across all CBT groups, means of clinical severity, anxiety, and internalizing symptoms significantly decreased posttreatment and were comparable across groups. The group without emphasis on CM or TC showed a higher proportion with posttreatment anxiety diagnoses than the low-involvement group. Between posttreatment and 1-year follow-up, the proportion with anxiety diagnoses significantly decreased in CBT with active parental involvement with emphasis on CM or TC, whereas treatment gains were merely maintained in the other 2 groups. CBT for anxious children is an effective treatment with or without active parental involvement. However, CBT with active parental involvement emphasizing CM or TC may support long-term maintenance of treatment gains. RESULTS should be replicated as additional RCTs are published.

  6. 75 FR 4111 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2010-01-26

    ... value for all steam generators, both hot and cold legs, in Table RA124-2. Specifically, for the... possibility of a new or different kind of accident from any accident previously evaluated; or (3) involve a...-mail to [email protected] . Arizona Public Service Company, et al., Docket Nos. STN 50-528, STN 50...

  7. 76 FR 6830 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-02-08

    ...- and 6- day supply is based on the diesel generator manufacturer's consumption values for the run time... different kind of accident from any accident previously evaluated; or (3) involve a significant reduction in... Company, Docket Nos. 50-325 and 50-324, Brunswick Steam Electric Plant, Units 1 and 2, Brunswick County...

  8. 76 FR 55125 - Biweekly Notice; Applications and Amendments to Facility Operating Licenses Involving No...

    Science.gov (United States)

    2011-09-06

    ... submission form. In order to serve documents through the Electronic Information Exchange System, users will... primary containment atmosphere gaseous radioactivity monitor. The monitoring of RCS leakage is not a... atmosphere gaseous radioactivity monitor. The proposed change does not involve a physical alteration of the...

  9. Frequency and Type of Hepatic and Gastrointestinal Involvement in Juvenile Systemic Lupus Erythematosus

    Directory of Open Access Journals (Sweden)

    Leila Tahernia

    2017-01-01

    Full Text Available Background. Systemic lupus erythematosus (SLE is a frequent rheumatology disorder among children. Since hepatic involvement is a common systemic manifestation in lupus, the frequency and type of hepatic involvement were determined in pediatric cases of SLE admitted to Children’s Medical Hospital from 2005 to 2014. Methods and Patients. In this observational case-series study, 138 pediatric cases of SLE were admitted in Children’s Medical Center (a pediatric rheumatology referral center in Tehran, Iran enrolled from 2005 to 2014 and the outcomes, frequency, and type of hepatic involvement were assessed among them. Results. Hepatic involvement was reported in 48.55% of total SLE patients. Aspartate aminotransferase (AST, alanine aminotransferase (ALT, and both enzymes higher than normal upper limits were detected in 8.7%, 5%, and 34.7% of lupus patients, respectively. Increased level of liver enzymes was categorized as less than 100, between 100 and 1000, and more than 1000 levels in 23.1%, 23.1%, and 2.1% of cases. The only gastrointestinal involvement in lupus patients contributing to hepatic involvement was gastrointestinal bleeding. Rising in liver enzymes was detected mostly in lupus patients without gastrointestinal bleeding (52.2% without versus 25.8% with gastrointestinal bleeding, P=0.007. Conclusion. Approximately half of the pediatric patients suffering from SLE have hepatic involvement. No significant correlation was observed between various organs involvement and abnormal level of liver enzymes.

  10. Parenting goals: predictors of parent involvement in disease management of children with type 1 diabetes.

    Science.gov (United States)

    Robinson, Elizabeth M; Iannotti, Ronald J; Schneider, Stefan; Nansel, Tonja R; Haynie, Denise L; Sobel, Douglas O

    2011-09-01

    The purpose of this study was to develop a measure of diabetes-specific parenting goals for parents of children with type 1 diabetes and to examine whether parenting goals predict a change in parenting involvement in disease management. An independent sample of primary caretakers of 87 children aged 10 to 16 years with type 1 diabetes completed the measure of parenting goals (diabetes-specific and general goals); both parent and child completed measures of parent responsibility for diabetes management at baseline and 6 months. Parents ranked diabetes-specific parenting goals as more important than general parenting goals, and rankings were moderately stable over time. Parenting goals were related to parent responsibility for diabetes management. The relative ranking of diabetes-specific parenting goals predicted changes in parent involvement over 6 months, with baseline ranking of goals predicting more parental involvement at follow-up. Parenting goals may play an important role in family management of type 1 diabetes.

  11. Activity involvement and quality of life of people at different stages of dementia in long term care facilities.

    Science.gov (United States)

    Smit, Dieneke; de Lange, Jacomine; Willemse, Bernadette; Twisk, Jos; Pot, Anne Margriet

    2016-01-01

    Involvement in activities is assumed to positively influence the quality of life of people with dementia, yet activity provision in long-term care remains limited. This study aims to provide more insight into the value of activity involvement for domains of the quality of life of long-term dementia care residents, taking resident characteristics and cognitive status into account. Data were derived from 144 long-term care facilities participating in the second measurement (2010/2011) of the living arrangements for dementia study. Amongst 1144 residents, the relationship between time involved in activities (activity pursuit patterns; RAI-MDS) and quality of life (Qualidem) was studied using multilevel linear regression analyses. Analyses were adjusted for residents' age, gender, neuropsychiatric symptoms, ADL dependency and cognition. To check for effect modification of cognition, interactions terms of the variables activity involvement and cognitive status were added to the analyses. Despite resident's cognitive status, their activity involvement was significantly related to better scores on care relationship, positive affect, restless tense behaviour, social relations, and having something to do. A negative relationship existed between the activity involvement and positive self-image. The explained variance in the quality of life between residents caused by the activity involvement was small. Activity involvement seems to be a small yet important contributor to higher well-being in long-term care resident at all stages of dementia. Adjusting activities to individual preferences and capabilities might enlarge this relationship. Further research is needed to confirm this hypothesis, using measurement instruments less sensitive to recall bias and differentiating between the active and passive activity involvement.

  12. The effect of types of banner ad, Web localization, and customer involvement on Internet users' attitudes.

    Science.gov (United States)

    Chen, Jengchung Victor; Ross, William H; Yen, David C; Akhapon, Lerdsuwankij

    2009-02-01

    In this study, three characteristics of Web sites were varied: types of banner ad, Web localization, and involvement in purchasing a product. The dependent variable was attitude toward the site. In laboratory experiments conducted in Thailand and Taiwan, participants browsed versions of a Web site containing different types of banner ads and products. As a within-participants factor, each participant browsed both a standardized English-language Web site and a localized Web site. Results showed that animated (rather than static) banner ads, localized versions (rather than a standardized version) of Web sites, and high (rather than low) product involvement led to favorable attitudes toward the site.

  13. 77 FR 66486 - Applications and Amendments to Facility Operating Licenses and Combined Licenses Involving...

    Science.gov (United States)

    2012-11-05

    ... available; and (iii) the filing has been submitted in a timely fashion based on the availability of the....12 to >= 1.17. The change is required to support the LSCS, Unit 2, Cycle 15, operation. Cycle 15 will be the first cycle of operation with a mixed core containing the following fuel types: Global Nuclear...

  14. Creating and managing radioactive waste disposal facilities with the involvement of the local populations - 59286

    International Nuclear Information System (INIS)

    Farin, Sebastien

    2012-01-01

    Document available in abstract form only. Full text of publication follows: Andra is responsible for proposing and implementing industrial management solutions for all French radioactive waste. Andra is in particular in charge of operating the two repositories in the Aube region, monitoring the Manche repository one of the world's first surface repositories and creating disposal facilities for waste currently without an operational disposal solution. Andra's communication approach. Andra's communication role is stipulated by law and is an integral part of its activities, in the same way as research, industry or risk management. Andra's aim is to make the subject of radioactive waste management one that is of nationwide interest comprehensible to the largest possible number, so that each citizen and stakeholder can, in full possession of the facts, make his or her own opinion and finally reach an informed decision. Andra's communication policy is based on four main levers: - Information, through a full range of tools (web sites, publications, periodicals) adapted to the level of expertise and understanding of its various target audiences; - Explanation, by means of opportunities throughout the year for those interested in the subject (site visits, fairs, meetings with schools, travelling exhibitions, etc.); - Local integration, through regular relations with local players

  15. Nerve ultrasound shows subclinical peripheral nerve involvement in neurofibromatosis type 2.

    Science.gov (United States)

    Telleman, Johan A; Stellingwerff, Menno D; Brekelmans, Geert J; Visser, Leo H

    2018-02-01

    Neurofibromatosis type 2 (NF2) is mainly associated with central nervous system (CNS) tumors. Peripheral nerve involvement is described in symptomatic patients, but evidence of subclinical peripheral nerve involvement is scarce. We conducted a cross-sectional pilot study in 2 asymptomatic and 3 minimally symptomatic patients with NF2 to detect subclinical peripheral nerve involvement. Patients underwent clinical examination, nerve conduction studies (NCS), and high-resolution ultrasonography (HRUS). A total of 30 schwannomas were found, divided over 20 nerve segments (33.9% of all investigated nerve segments). All patients had at least 1 schwannoma. Schwannomas were identified with HRUS in 37% of clinically unaffected nerve segments and 50% of nerve segments with normal NCS findings. HRUS shows frequent subclinical peripheral nerve involvement in NF2. Clinicians should consider peripheral nerve involvement as a cause of weakness and sensory loss in the extremities in patients with this disease. Muscle Nerve 57: 312-316, 2018. © 2017 Wiley Periodicals, Inc.

  16. A model for plasma evolution in Filipov type plasma focus facilities

    International Nuclear Information System (INIS)

    Siahpoush, V.; Sobhanian, S.; Tafreshi, M. A.; Lamehi, M.

    2003-01-01

    A model is presented in this paper for the evolution of plasma in Filipov type plasma focus facilities. With the help of this model, one can predict some of the main parameters of the produced plasma and obtain the optimized geometrical an physical properties (anode radius and length, gas pressure, capacitance, bank energy etc) for the primary design purposes. The results obtained by this model will be compared with the experimental data obtained from the 90 kJ plasma focus facility D ena

  17. Cardiac involvement in patients with limb-girdle muscular dystrophy type 2 and Becker muscular dystrophy

    DEFF Research Database (Denmark)

    Sveen, Marie-Louise; Thune, Jens Jakob; Køber, Lars

    2008-01-01

    OBJECTIVE: To investigate the extent of cardiac involvement in patients with 1 of the 12 groups of recessively inherited limb-girdle muscular dystrophy type 2 (LGMD2A-L) and Becker muscular dystrophy (BMD). DESIGN: Prospective screening. SETTING: Neuromuscular Clinic and Department of Cardiology...

  18. Emotional Creativity and Real-Life Involvement in Different Types of Creative Leisure Activities

    Science.gov (United States)

    Trnka, Radek; Zahradnik, Martin; Kuška, Martin

    2016-01-01

    The role of emotional creativity in practicing creative leisure activities and in the preference of college majors remains unknown. This study aims to explore how emotional creativity measured by the Emotional Creativity Inventory (ECI; Averill, 1999) is interrelated with the real-life involvement in different types of specific creative leisure…

  19. The progress and results of a demonstration test of a cavern-type disposal facility

    International Nuclear Information System (INIS)

    Akiyama, Yoshihiro; Terada, Kenji; Oda, Nobuaki; Yada, Tsutomu; Nakajima, Takahiro

    2011-01-01

    The cavern-type disposal facilities for low-level waste (LLW) with relatively high radioactivity levels mainly generated from power reactor decommissioning and for part of transuranic (TRU) waste mainly from spent fuel reprocessing are designed to be constructed in a cavern 50 to 100 meters below ground, and to employ an engineered barrier system (EBS) of a combination of bentonite and cement materials in Japan. In order to advance the feasibility study for these disposal, a government-commissioned research project named Demonstration Test of Cavern-Type Disposal Facility started in fiscal 2005, and since fiscal 2007 a full-scale mock-up test facility has been constructed under actual subsurface environment. The main objective of the test is to establish construction methodology and procedures which ensure the required quality of the EBS on-site. By fiscal 2009 some parts of the facility have been constructed, and the test has demonstrated both practicability of the construction and achievement of the quality. They are respectively taken as low-permeability of less than 5x10 13 m/s and low-diffusivity of less than 1x10 -12 m 2 /s at the time of completion of construction. This paper covers the project outline and the test results obtained by the construction of some parts of a bentonite and cement materials. (author)

  20. Current status of the Demonstration Test of Underground Cavern-Type Disposal Facilities

    International Nuclear Information System (INIS)

    Akiyama, Yoshihiro; Terada, Kenji; Oda, Nobuaki; Yada, Tsutomu; Nakajima, Takahiro

    2011-01-01

    In Japan, the underground cavern-type disposal facilities for low-level waste (LLW) with relatively high radioactivity, mainly generated from power reactor decommissioning, and for certain transuranic (TRU) waste, mainly from spent fuel reprocessing, are designed to be constructed in a cavern 50-100 m underground and to employ an engineered barrier system (EBS) made of bentonite and cement materials. To advance a disposal feasibility study, the Japanese government commissioned the Demonstration Test of Underground Cavern-Type Disposal Facilities in fiscal year (FY) 2005. Construction of a full-scale mock-up test facility in an actual subsurface environment started in FY 2007. The main test objective is to establish the construction methodology and procedures that ensure the required quality of the EBS on-site. A portion of the facility was constructed by 2010, and the test has demonstrated both the practicability of the construction and the achievement of quality standards: low permeability of less than 5x10 -13 m/s and low-diffusion of less than 1x10 -12 m 2 /s at the completion of construction. This paper covers the test results from the construction of certain parts using bentonite and cement materials. (author)

  1. Design Methodology of Process Layout considering Various Equipment Types for Large scale Pyro processing Facility

    International Nuclear Information System (INIS)

    Yu, Seung Nam; Lee, Jong Kwang; Lee, Hyo Jik

    2016-01-01

    At present, each item of process equipment required for integrated processing is being examined, based on experience acquired during the Pyropocess Integrated Inactive Demonstration Facility (PRIDE) project, and considering the requirements and desired performance enhancement of KAPF as a new facility beyond PRIDE. Essentially, KAPF will be required to handle hazardous materials such as spent nuclear fuel, which must be processed in an isolated and shielded area separate from the operator location. Moreover, an inert-gas atmosphere must be maintained, because of the radiation and deliquescence of the materials. KAPF must also achieve the goal of significantly increased yearly production beyond that of the previous facility; therefore, several parts of the production line must be automated. This article presents the method considered for the conceptual design of both the production line and the overall layout of the KAPF process equipment. This study has proposed a design methodology that can be utilized as a preliminary step for the design of a hot-cell-type, large-scale facility, in which the various types of processing equipment operated by the remote handling system are integrated. The proposed methodology applies to part of the overall design procedure and contains various weaknesses. However, if the designer is required to maximize the efficiency of the installed material-handling system while considering operation restrictions and maintenance conditions, this kind of design process can accommodate the essential components that must be employed simultaneously in a general hot-cell system

  2. First lasings at IR-and FIR range using hybrid type undulator (FEL facility 4) and Halbach type undulator

    International Nuclear Information System (INIS)

    Takii, T.; Oshita, E.; Okuma, S.; Wakita, K.; Koga, A.; Tomimasu, T.; Ohasi, K.

    1997-01-01

    First lasing at 18μm was achieved by using a 2.7-m long hybrid type undulator (undulator 4) for far-infrared FELs and a 6.72-m long optical cavity installed at the 33-MeV beam line of the downstream of the FEL facility 1 (FEL-1). We are challenged at two-color FEL oscillation in mid-infrared range using the undulator 1 (λ u=3.4mm) and in far-infrared range using the undulator 4 (λ u=9mm). At first, a 30-MeV, 60-A beam passed through the undulator 1 without lasing is transported using a QFQDBQFQDBQFQDQF system and is used for lasing at the undulator 4. However, six pairs of steering coils had to be attached on the beam duct to reduce the deviation of the electron beam trajectory due to the vertical field distribution induced by the built-in electromagnets. The minimum gap of the undulator 4 was designed to be 35mm. However, the steering coils attached on the beam duct increased the gap up to 52mm. Therefore, the hybrid type undulator was replaced by a new Halbach type one (λ u=8mm, N=30) after the first lasing at 18μm on October 24, '96. The New FEL facility 4 was installed in the middle of December and first lasing at 18.6μm was achieved on December 26, within 10 hours operation. (author)

  3. Formation of wood secondary cell wall may involve two type cellulose synthase complexes in Populus.

    Science.gov (United States)

    Xi, Wang; Song, Dongliang; Sun, Jiayan; Shen, Junhui; Li, Laigeng

    2017-03-01

    Cellulose biosynthesis is mediated by cellulose synthases (CesAs), which constitute into rosette-like cellulose synthase complexe (CSC) on the plasma membrane. Two types of CSCs in Arabidopsis are believed to be involved in cellulose synthesis in the primary cell wall and secondary cell walls, respectively. In this work, we found that the two type CSCs participated cellulose biosynthesis in differentiating xylem cells undergoing secondary cell wall thickening in Populus. During the cell wall thickening process, expression of one type CSC genes increased while expression of the other type CSC genes decreased. Suppression of different type CSC genes both affected the wall-thickening and disrupted the multilaminar structure of the secondary cell walls. When CesA7A was suppressed, crystalline cellulose content was reduced, which, however, showed an increase when CesA3D was suppressed. The CesA suppression also affected cellulose digestibility of the wood cell walls. The results suggest that two type CSCs are involved in coordinating the cellulose biosynthesis in formation of the multilaminar structure in Populus wood secondary cell walls.

  4. Assessment of the radiological risks of road transport accidents involving type A package shipments

    International Nuclear Information System (INIS)

    Lange, F.; Fett, H.J.; Schwarz, G.; Raffestin, D.; Schneider, T.; Gelder, R.; Hughes, J.S.; Shaw, K.B.; Hedberg, B.; Simenstad, P.; Svahn, B.; Hienen, J.F.A.; Jansma, R.

    1998-01-01

    This paper is an account of work performed within a multi-lateral research project on the radiological risks associated with the transportation of Type A packaged radioactive material. The research project has been performed on behalf of the European Commission and various national agencies of the participating countries and involved organizations and institutes of five EU Member States, France, Germany, The Netherlands, Sweden, and the UK. The main objectives of the research project were the assessment and appraisal of the potential radiological risks of road transport accidents involving Type A package shipments in participating EU Member States. Data were collected and include harmonized sets information related to the type, quantity and characteristics of Type A package shipments by road. Such databases were basically non-existent until recently. The results are expected to be valuable to both national agencies and international organizations, with responsibilities for the safe transport of radioactive materials by providing some insight in the carriage of radioactive materials by road making up a major fraction of radioactive material transports. Similarly, a wide body of information has been collected and compiled on road transport accidents in terms of the frequency of occurrence and the severity of accidental impact loads potentially experienced by a Type A package.In addition, the results will facilitate judgement of the adequacy of the IAEA Transport Regulations as far as Type A packages are concerned. (O.M.)

  5. Fathers of children with Down's syndrome versus other types of intellectual disability: perceptions, stress and involvement.

    Science.gov (United States)

    Ricci, L A; Hodapp, R M

    2003-01-01

    The present study examined fathers' perceptions of, stress relating to and involvement with children with Down's syndrome (DS) (n = 30) versus those with other types of intellectual disability (ID) (n = 20). Fathers and mothers completed questionnaires about their children's personalities and maladaptive behaviours, their own parenting stress, and the fathers' level of involvement. Both fathers and mothers rated their children with DS as having more positive personality traits and fewer maladaptive behaviours. Possibly because of these positive perceptions, fathers of children with DS also reported less child-related stress, particularly in the areas of acceptability, adaptability and demandingness. The two groups of fathers were very similarly involved in child rearing. The personality, age and maladaptive behaviours of the children related to stress levels in the fathers of children with DS, while maladaptive behaviours, gender and the fathers' education levels related to stress levels in the fathers of children with other types of ID. These results highlight the importance of examining parental stress and involvement with children with different types of ID.

  6. Vulnerability Analysis for Physical Protection System at Hypothetical Facility of a Different Type Reactor

    International Nuclear Information System (INIS)

    Jung, Won-Moog; Kim, Jung-Soo; Kim, Jae-Kwang; Yoo, Ho-Sik; Kwak, Sung-Ho; Jang, Sung-Soon

    2007-01-01

    Since the 9/11 event in the U.S.A, International terror possibilities has been increased for nuclear facilities including nuclear power plants(NPPs). It is necessary to evaluate the performance of an existing physical protection system(PPS) at nuclear facilities based on such malevolent acts. Detection, delay, and response elements are all important to PPS. They are used for the analysis and evaluation of a PPS and its effectiveness. Methods are available to analyze a PPS and evaluate its effectiveness. Sandia National Laboratory(SNL) in the U.S.A developed a System Analysis of Vulnerability to Intrusion (SAVI) computer code for evaluating the effectiveness of PPS against outsider threats. This study presents the vulnerability analysis of the PPS at hypothetical facility of a different type using SAVI code that the basic input parameters are from PPS of a different type. For analysis, first, the site-specific Adversary Sequence Diagrams(ASDs) of the PPS is designed. It helps to understand the functions of the existing PPS composed of physical areas and Protection Elements(PEs). Then, the most vulnerable path of an ASD as a measure of effectiveness is determined. The results in the analysis can compare with the most vulnerable paths at a different type

  7. Test facility of the VVER-440 condensation-type pressure suppression system

    International Nuclear Information System (INIS)

    Wolff, H.; Arndt, S.

    2004-01-01

    Since the early nineties, GRS has supported regulatory authorities in Central and Eastern Europe in performing safety assessments of nuclear power plants. Especially studies of the condensation-type pressure suppression system of VVER-440/V-213-type plants have been important in this respect. Major steps in demonstrating complete functioning of the condensation-type pressure suppression system under accident conditions by experiments run in the Russian large scale test facility, BC V-213, have been completed in the past two years within the framework of various international experimental programs. The test results were used to validate specifically for power plants with VVER-400/V-213 reactors the COCOSYS GRS computer code, which is used in the safety assessments. The results of recalculations of the C02 EREC test, which simulates a break of a main steam pipe, demonstrate the present state of validation of COCOSYS for VVER condensation-type pressure suppression systems. (orig.) [de

  8. Paternal involvement in pediatric Type 1 diabetes: fathers' and mothers' psychological functioning and disease management.

    Science.gov (United States)

    Hansen, Jennifer A; Weissbrod, Carol; Schwartz, David D; Taylor, W Patrick

    2012-03-01

    Psychological functioning in fathers of children with Type 1 diabetes has received relatively little attention compared to mothers. This study examined fathers' perceived involvement in their children's diabetes care as it related to mothers' and fathers' pediatric parenting stress, depression, anxiety, marital satisfaction, and sleep, and to their children's diabetes regimen adherence and glycemic control. Eighty-two mothers and 43 fathers completed questionnaires. Multivariate linear regressions were conducted separately for mothers and fathers to determine the relationships between the perceived amount and the perceived helpfulness of father involvement in child diabetes care on parental psychosocial functioning and child diabetes control. Maternal perceptions of father helpfulness and amount of involvement in illness care were related to improved marital satisfaction and fewer depressive symptoms in mothers. In fathers, perception of their own amount of involvement was related to increased pediatric parenting stress and anxiety. Better child regimen adherence was associated with maternal perceptions of father helpfulness but not the amount of their involvement, while paternal perceptions of their own helpfulness were related to poorer glycemic control. These findings suggest that fathers and mothers may react differently to their roles in childhood illness and that perceptions of their involvement may be differently associated with children's glycemic control and regimen adherence.

  9. A statistical description of the types and severities of accidents involving tractor semi-trailers

    International Nuclear Information System (INIS)

    Clauss, D.B.; Wilson, R.K.; Blower, D.F.; Campbell, K.L.

    1994-06-01

    This report provides a statistical description of the types and severities of tractor semi-trailer accidents involving at least one fatality. The data were developed for use in risk assessments of hazardous materials transportation. Several accident databases were reviewed to determine their suitability to the task. The TIFA (Trucks Involved in Fatal Accidents) database created at the University of Michigan Transportation Research Institute was extensively utilized. Supplementary data on collision and fire severity, which was not available in the TIFA database, were obtained by reviewing police reports for selected TIFA accidents. The results are described in terms of frequencies of different accident types and cumulative distribution functions for the peak contact velocity, rollover skid distance, fire temperature, fire size, fire separation, and fire duration

  10. Strategies for energy benchmarking in cleanrooms and laboratory-type facilities

    International Nuclear Information System (INIS)

    Sartor, Dale; Piette, Mary Ann; Tschudi, William; Fok, Stephen

    2000-01-01

    Buildings with cleanrooms and laboratories are growing in terms of total floor area and energy intensity. This building type is common in institutions such as universities and in many industries such as microelectronics and biotechnology. These buildings, with high ventilation rates and special environmental considerations, consume from 4 to 100 times more energy per square foot than conventional commercial buildings. Owners and operators of such facilities know they are expensive to operate, but have little way of knowing if their facilities are efficient or inefficient. A simple comparison of energy consumption per square foot is of little value. A growing interest in benchmarking is also fueled by: A new U.S. Executive Order removing the exemption of federal laboratories from energy efficiency goals, setting a 25% savings target, and calling for baseline guidance to measure progress; A new U.S. EPA and U.S. DOE initiative, Laboratories for the 21st Century, establishing voluntary performance goals and criteria for recognition; and A new PG and E market transformation program to improve energy efficiency in high tech facilities, including a cleanroom energy use benchmarking project. This paper identifies the unique issues associated with benchmarking energy use in high-tech facilities. Specific options discussed include statistical comparisons, point-based rating systems, model-based techniques, and hierarchical end-use and performance-metrics evaluations

  11. Comparison and discussion of two types of threat (Hazard) categorization method for nuclear facilities

    International Nuclear Information System (INIS)

    Tang, Rongyao; Xu, Xiaoxiao; Zhang, Jiangang; Zhao, Bin

    2008-01-01

    The emergency threat categorization method suggested by international atomic energy agency (IAEA) and hazard categorization standard by the Department of Energy of United States (USDOE) for nuclear facilities are compared and discussed in this paper. The research shows the two types of categorization method for nuclear facility are similar, though each has its own speciality. The categorization method suggested by IAEA is quite completed and sound in scientific basis. The thresholds of radioactive material are connected with the quantity of dangerous source, and the latest radiobiological effect research results are taken in setting the thresholds. While the main purpose is put on emergency management, some of the categorization criteria do not fit for safety surveillance of nuclear facilities. The categorization method of DOE is advanced in its operability, and it fits for safety surveillance. The disadvantage is that the thresholds of radioactive material need to be updated because the parameters used in calculation is outdated, and also the threshold of category 3 is somewhat disputable for many reasons. We should take advantage of both methods and adjust the standards according to the application purpose while establishing the categorization standard of nuclear facilities in China. (author)

  12. Development and Validation of the Collaborative Parent Involvement Scale for Youths with Type 1 Diabetes

    OpenAIRE

    Nansel, Tonja R.; Rovner, Alisha J.; Haynie, Denise; Iannotti, Ronald J.; Simons-Morton, Bruce; Wysocki, Timothy; Anderson, Barbara; Weissberg-Benchell, Jill; Laffel, Lori

    2008-01-01

    Objective To develop and test a youth-report measure of collaborative parent involvement in type 1 diabetes management. Methods Initial item development and testing were conducted with 81 youths; scale refinement and validation were conducted with 122 youths from four geographic regions. Descriptive statistics, Cronbach's α, and factor analyses were conducted to select items comprising the scale. Correlations with parenting style and parent diabetes responsibility were examined. Multiple regr...

  13. Development and validation of the collaborative parent involvement scale for youths with type 1 diabetes.

    Science.gov (United States)

    Nansel, Tonja R; Rovner, Alisha J; Haynie, Denise; Iannotti, Ronald J; Simons-Morton, Bruce; Wysocki, Timothy; Anderson, Barbara; Weissberg-Benchell, Jill; Laffel, Lori

    2009-01-01

    To develop and test a youth-report measure of collaborative parent involvement in type 1 diabetes management. Initial item development and testing were conducted with 81 youths; scale refinement and validation were conducted with 122 youths from four geographic regions. Descriptive statistics, Cronbach's alpha, and factor analyses were conducted to select items comprising the scale. Correlations with parenting style and parent diabetes responsibility were examined. Multiple regression analyses examining associations with quality of life, adherence, and glycemic control were conducted to assess concurrent validity. The measure demonstrated strong internal consistency. It was modestly associated with parenting style, but not with parent responsibility for diabetes management. A consistent pattern of associations with quality of life and adherence provide support for the measure's concurrent validity. This brief youth-report measure of parent collaborative involvement assesses a unique dimension of parent involvement in diabetes management associated with important youth outcomes.

  14. User involvement and supporting tools in business-to-business service innovations: Insights from Facility Management services

    DEFF Research Database (Denmark)

    Nardelli, Giulia

    is the generalizability of the findings to other business-to-business service sectors. More research conducted both in FM services and other service sectors would help to shed light on the generalizability of these findings. Originality/value – The study contributes with new and detailed insights into the complexity......Purpose – This article investigates and conceptualizes user involvement in business-to-business service innovations as well as the tools that are used to support interactions in such a service innovation process. Design/methodology/approach – The paper uses a qualitative research approach to answer...... the research question. By following Miles and Huberman (1984)’s this study started with a literature review of studies investigating service innovation, service innovations models, user roles and tools in service innovation in general, to conduct an empirical investigation in facility management (FM) services...

  15. Assessment of the radiological risks of road transport accidents involving Type A packages

    International Nuclear Information System (INIS)

    Lange, F.; Fett, H.J.; Schwarz, G.; Raffestin, D.; Schneider, T.; Gelder, R.; S. Hughes, J.; B. Shaw, K.; Hedberg, B.; Simenstad, P.; Svahn, B.; Heinen, J.F.A. van; Jansma, R.

    2001-01-01

    An assessment and evaluation of the potential radiological risks of transport accidents involving Type A package shipments by road have been performed by five EU Member States, France, Germany, Sweden, The Netherlands, and the UK. The analysis involved collection and analysis of information on a national basis related to the type, volume, and characteristics of Type A package consignments, the associated radioactive traffic, and the expected frequency and consequences of potential vehicular road transport accidents. It was found that the majority of Type A packaged radioactive material shipments by road is related to applications of non-special form radioactive material, i.e. radiopharmaceuticals, radiochemicals etc., in medicine, research, and industry and special form material contained in radiography and other radiation sources, e.g. gauging equipment. The annual volumes of Type A package shipments of radiopharmaceuticals and radiochemicals by road differ considerably between the participating EU Member States from about 12,000 Type A packages in Sweden to about 240,000 in the Netherlands. The broad range reflects to a large extent the supply of radioactive material for the national populations and the production and distribution operations prevailing in the participating EU Member States (some are producer countries, others are not!). Very few standard package designs weighing from about 1-25 kg are predominant in Type A package shipments in all participating countries. Type A packages contain typically a range of radioactivity from a few mega becquerels to a few tens of giga becquerels, the average package activity contents is in terms of fractions of A 2 about 0.01, i.e. about one hundredth of a Type A package contents limits. Based on a probabilistic risk assessment method it has been concluded that the expected frequencies of occurrence of vehicular road transport accidents with the potential to result in an environmental release - including radiologically

  16. Facile synthesis of birnessite-type manganese oxide nanoparticles as supercapacitor electrode materials.

    Science.gov (United States)

    Liu, Lihu; Luo, Yao; Tan, Wenfeng; Zhang, Yashan; Liu, Fan; Qiu, Guohong

    2016-11-15

    Manganese oxides are environmentally benign supercapacitor electrode materials and, in particular, birnessite-type structure shows very promising electrochemical performance. In this work, nanostructured birnessite was facilely prepared by adding dropwise NH2OH·HCl to KMnO4 solution under ambient temperature and pressure. In order to fully exploit the potential of birnessite-type manganese oxide electrode materials, the effects of specific surface area, pore size, content of K(+), and manganese average oxidation state (Mn AOS) on their electrochemical performance were studied. The results showed that with the increase of NH2OH·HCl, the Mn AOS decreased and the corresponding pore sizes and specific surface area of birnessite increased. The synthesized nanostructured birnessite showed the highest specific capacitance of 245Fg(-1) at a current density of 0.1Ag(-1) within a potential range of 0-0.9V, and excellent cycle stability with a capacitance retention rate of 92% after 3000 cycles at a current density of 1.0Ag(-1). The present work implies that specific capacitance is mainly affected by specific surface area and pore volume, and provides a new method for the facile preparation of birnessite-type manganese oxide with excellent capacitive performance. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Results of 15 years experiments in the PMK-2 integral-type facility for VVERs

    Energy Technology Data Exchange (ETDEWEB)

    Szabados, L.; Ezsoel, G.; Perneczky, L. [KFKI Atomic Energy Research Institute, Budapest (Hungary)

    2001-07-01

    Due to the specific features of the VVER-440/213-type reactors the transient behaviour of such a reactor system is different from the usual PWR system behaviour. To provide an experimental database for the transient behaviour of VVER systems the PMK integral-type facility, the scaled down model of the Paks NPP was designed and constructed in the early 1980's. Since the start-up of the facility 48 experiments have been performed. It was confirmed through the experiments that the facility is a suitable tool for the computer code validation experiments and to the identification of basic thermal-hydraulic phenomena occurring during plant accidents. High international interest was shown by the four Standard Problem Exercises of the IAEA and by the projects financed by the EU-PHARE. A wide range of small- and medium-size LOCA sequences have been studied to know the performance and effectiveness of ECC systems and to evaluate the thermal-hydraulic safety of the core. Extensive studies have been performed to investigate the one- and two-phase natural circulation, the effect of disturbances coming from the secondary circuit and to validate the effectiveness of accident management measures like bleed and feed. The VVER-specific case, the opening of the SG collector cover was also extensively investigated. Examples given in the report show a few results of experiments and the results of calculation analyses performed for validation purposes of codes like RELAP5, ATHLET and CATHARE. There are some other white spots in Cross Reference Matrices for VVER reactors and, therefore, further experiments are planned to perform tests primarily in further support of accident management measures at low power states of plants to facilitate the improved safety management of VVER-440-type reactors. (authors)

  18. Results of 15 years experiments in the PMK-2 integral-type facility for VVERs

    International Nuclear Information System (INIS)

    Szabados, L.; Ezsoel, G.; Perneczky, L.

    2001-01-01

    Due to the specific features of the VVER-440/213-type reactors the transient behaviour of such a reactor system is different from the usual PWR system behaviour. To provide an experimental database for the transient behaviour of VVER systems the PMK integral-type facility, the scaled down model of the Paks NPP was designed and constructed in the early 1980's. Since the start-up of the facility 48 experiments have been performed. It was confirmed through the experiments that the facility is a suitable tool for the computer code validation experiments and to the identification of basic thermal-hydraulic phenomena occurring during plant accidents. High international interest was shown by the four Standard Problem Exercises of the IAEA and by the projects financed by the EU-PHARE. A wide range of small- and medium-size LOCA sequences have been studied to know the performance and effectiveness of ECC systems and to evaluate the thermal-hydraulic safety of the core. Extensive studies have been performed to investigate the one- and two-phase natural circulation, the effect of disturbances coming from the secondary circuit and to validate the effectiveness of accident management measures like bleed and feed. The VVER-specific case, the opening of the SG collector cover was also extensively investigated. Examples given in the report show a few results of experiments and the results of calculation analyses performed for validation purposes of codes like RELAP5, ATHLET and CATHARE. There are some other white spots in Cross Reference Matrices for VVER reactors and, therefore, further experiments are planned to perform tests primarily in further support of accident management measures at low power states of plants to facilitate the improved safety management of VVER-440-type reactors. (authors)

  19. [Cathepsin K as a biomarker of bone involvement in type 1 Gaucher disease].

    Science.gov (United States)

    Bobillo Lobato, Joaquín; Durán Parejo, Pilar; Núñez Vázquez, Ramiro J; Jiménez Jiménez, Luis M

    2015-10-05

    Gaucher disease is an inherited disorder caused by deficit of acid β-glucocerebrosidase, responsible for the degradation of glucosylceramide to ceramide and glucose. Although the disorder is primarily hematologic, bone is the second most commonly affected structure. Cathepsin K (CATK) is an enzyme involved in bone remodelling process. It has been proposed that determination of its serum concentrations may provide additional information to other biomarkers. The study included 20 control subjects and 20 Gaucher type 1 patients from Andalusia and Extremadura regions. We analyzed the biomarkers of bone remodelling: the bone alkaline phosphatase (B-ALP), the N-terminal propeptide of type 1 procollagen (P1NP), the β carboxyterminal telopeptide of type 1 collagen (CTx) and the CATK through electrochemiluminescence and immunoassay techniques. There is an increase in levels of CATK, CATK/P1NP and CATK/B-ALP ratios in type 1 Gaucher patients compared to the control group. Considering the existence of skeletal manifestations in the patient group, the CATK and CATK/P1NP ratio showed higher levels in patients with bone damage compared to those without it. Although imaging studies are the gold standard for monitoring bone disease in type 1 Gaucher patients, the utility of CATK should be considered as a possible indicator of bone damage in these patients. Furthermore, this parameter can be used in the monitoring of the treatment of bone pathology. Copyright © 2015 Elsevier España, S.L.U. All rights reserved.

  20. Types of parents’ involvement in early childhood development

    Directory of Open Access Journals (Sweden)

    Barbara Chojnacka-Synaszko

    2016-04-01

    Full Text Available Depending on their involvement in assisting their child’s development, parents may have various chances of improving and refining their childcare, parenting, and therapeutic methods. The objective of this study was to learn the opinions of the parents of children covered by the early intervention/early assisted-development programme regarding their own involvement in the processes, and determining which types of involvement, whether active or passive, the parents seem to practice. The empirical material was acquired in a survey conducted in the form of a questionnaire in May 2015 and June 2016, covering a total of 143 parents. According to our results, the respondents not only follow the recommendations provided by the specialists based at a given support centre (96.5%, but also actively seek information and knowledge related to activities and measures aimed at assisting their child’s development, incorporating them in daily childcare and education routine (88.8%. Most respondents (65% actively seek the specialists’ advice and opinion related to  the child’s education and development as well as keep the child company at the appointments, sessions, and activities held at the centre (63.65%. A large majority (90.2% combine various types of “active” (self-inspired involvement with “passive” (specialist-inspired involvement of supportive character. Each of the parents covered by the study engages in assisting the child’s development at home according to the specialists’ recommendations, or we might say, as inspired by the specialist team. There is a need for enhancing the parents’ “active” (self-inspired involvement in the child’s situation at the centre (encouraging initiativetaking as well as the parents’ specialist-inspired involvement in the child’s situation at the centre.

  1. Type B investigation report of curium-244 exposure at the ORNL TRU Facility, January 15, 1986

    International Nuclear Information System (INIS)

    Love, G.L.; Butler, H.M.; Duncan, D.T.; Oakes, T.W.

    1986-04-01

    This Type B Investigative Report provides an evaluation of relevant events and activities that led to, were a part of, or resulted from the release of curium-244 in the Building 7920 facility at ORNL in January 1986. Impacts have been evaluated with respect to employee exposures and the costs and loss of productivity resulting from increased bioassay analyses and activities of investigative committees. Management systems evaluated include (1) training of employees performing lab analyses, (2) adherence to procedures, and (3) response to unusual circumstances

  2. Neurofibromatosis type 1 with external genitalia involvement presentation of 4 patients.

    Science.gov (United States)

    Pascual-Castroviejo, Ignacio; Lopez-Pereira, Pedro; Savasta, Salvatore; Lopez-Gutierrez, Juan Carlos; Lago, Carlos Míguelez; Cisternino, Mariangela

    2008-11-01

    Genitourinary neurofibromas with clitoral involvement in neurofibromatosis type 1 are rare, and even more infrequent are the neurofibromas involving genitalia in males. The most frequent presenting sign of neurofibroma in females is clitoromegaly with pseudopenis, and enlarged penis is the most common sign in males. Labium majus neurofibroma not associated with clitoral involvement is extremely rare. Magnetic resonance imaging demonstration of the neurofibromas has seldom been reported. We report 4 children, 3 girls and 1 boy, with plexiform neurofibromas involving the external genitalia. Three of the 4 patients had histologic confirmation of neurofibroma. Two girls with clitoral hypertrophy had a neurofibroma that infiltrated the clitoris and extended unilaterally to the lower bladder wall. One girl had a plexiform neurofibroma that affected a labium. One boy with asymmetric penile hypertrophy since 2 years of age and ipsilateral gluteal hypertrophy had plexiform neurofibromas that extended between the left lumbogluteal and penile regions, infiltrating the left rectum wall and bladder with compression of both structures, the left prostate, and the left half of the cavernous corpi with hypertrophy of this part and asymmetry of the penis. Magnetic resonance imaging demonstrated in all patients that external genitalia and plexiform neurofibroma formed images of nondetachable structures. However, hermaphroditism was discarded by chromosomal study in all 3 girls before ratifying the diagnosis of external genitalia neurofibroma.

  3. PMK-2 the Hungarian integral type test facility. Documentations, publications and archivations of experiments

    International Nuclear Information System (INIS)

    Perneczky, L.; Guba, A.; Ezsoel, G.; Toth, I.; Szabados, L.

    2002-01-01

    The PMK-2 experimental facility at the KFKI-AEKI, Budapest, is a full pressure, scaled down model of the primary and partly the secondary circuit of the Paks NPP, which is equipped with four VVER-440/213-type reactors. Since the start-up of the facility altogether 48 experiments have been performed for groups of transients as follows: one- and two-phase natural circulation, loss of coolant accidents, special plant transients and experiments in support of accident management procedures. The results have been used for the validation of thermal-hydraulic system codes for VVER applications. Following the experiments a detailed documentation and archiving activity - using an optimised data storage - was required to preserve the essential information and to assure these for a widely utilisation for the international nuclear community. In the publication list related to the facility and the experiments for the moment altogether 280 items - documents, articles in periodicals, papers in proceedings and research reports - in six languages were collected. The paper gives an overview on this activity including the participation in the EU CERTA-TN programme, where AEKI introduced representative databases of two PMK-2 tests in the STRESA Network.(author)

  4. 43 CFR 404.9 - What types of infrastructure and facilities may be included in an eligible rural water supply...

    Science.gov (United States)

    2010-10-01

    ... facilities may be included in an eligible rural water supply project? 404.9 Section 404.9 Public Lands... RURAL WATER SUPPLY PROGRAM Overview § 404.9 What types of infrastructure and facilities may be included in an eligible rural water supply project? A rural water supply project may include, but is not...

  5. Type A Dissection Involving Intimo-Intimal Intussusception Through the Aortic Valve.

    Science.gov (United States)

    Armour, Trygve; Armour, Sarah; Reddy, Pingle; Brinster, Derek

    2015-07-15

    The presentation, evaluation, management, and outcome of a case of type A circumferential dissection involving repeated retrograde intussusception of the intimal flap through the aortic valve is described in this case report. Fewer than 20 intimo-intimal intussusception cases have been described since the first report was published by Hufnagel in 1962, and outcomes have typically been poor because of delays in diagnosis. This case shows the potential for a positive outcome when the diagnosis of intimo-intimal intussusception is entertained and confirmed early in the course of treatment. Preoperative computed tomography and intraoperative transesophageal echocardiography were essential in diagnosis and operative planning.

  6. MR imaging in adults with Gaucher disease type I: evulation of marrow involvement and disease activity

    Energy Technology Data Exchange (ETDEWEB)

    Hermann, G. (Dept. of Radiology, Mount Sinai Medical Center, City Univ. of New York, NY (United States)); Shaprio, R.S. (Dept. of Radiology, Mount Sinai Medical Center, City Univ. of New York, NY (United States)); Abdelwahab, I.F. (Dept. of Radiology, Mount Sinai Medical Center, City Univ. of New York, NY (United States)); Grabowski, G. (Dept. of Pediatrics, Mount Sinai Medical Center, City Univ. of New York, NY (United States))

    1993-05-01

    An investigation was conducted to determine the usefulness of magnetic resonance imaging (MRI) in the evaluation of bone marrow involvement in patients with Gaucher disease type I. T1- and T2-weighted images were obtained of the lower extremities of 29 adult patients. Patients were classified into one of three groups based on marrow signal patterns on T1- and T2-weighted images as well as change in signal intensity from T1- to T2-weighted images. An increase in signal intensity from T1- to T2-weighted images was the criterion for an 'active process' within the bone marrow. Classification of the 29 patients produced the following results: Group A: Normal, 4 patients; group B: Marrow infiltration, 16 patients; group C: Marrow infiltration plus active marrow process, 9 patients. Correlation with clinical findings revealed that all nine patients with evidence of an active marrow process on MRI (group C) had acute bone pain. Conversely, only one of the remaining 20 patients (groups A and B) had bone pain. There was no correlation between disease activity and findings on conventional radiographs. We conclude the MRI provides an excellent noninvasive assessment of the extent and activity of marrow involvement in type I Gaucher disease. (orig.)

  7. MR imaging in adults with Gaucher disease type I: evulation of marrow involvement and disease activity

    International Nuclear Information System (INIS)

    Hermann, G.; Shaprio, R.S.; Abdelwahab, I.F.; Grabowski, G.

    1993-01-01

    An investigation was conducted to determine the usefulness of magnetic resonance imaging (MRI) in the evaluation of bone marrow involvement in patients with Gaucher disease type I. T1- and T2-weighted images were obtained of the lower extremities of 29 adult patients. Patients were classified into one of three groups based on marrow signal patterns on T1- and T2-weighted images as well as change in signal intensity from T1- to T2-weighted images. An increase in signal intensity from T1- to T2-weighted images was the criterion for an 'active process' within the bone marrow. Classification of the 29 patients produced the following results: Group A: Normal, 4 patients; group B: Marrow infiltration, 16 patients; group C: Marrow infiltration plus active marrow process, 9 patients. Correlation with clinical findings revealed that all nine patients with evidence of an active marrow process on MRI (group C) had acute bone pain. Conversely, only one of the remaining 20 patients (groups A and B) had bone pain. There was no correlation between disease activity and findings on conventional radiographs. We conclude the MRI provides an excellent noninvasive assessment of the extent and activity of marrow involvement in type I Gaucher disease. (orig.)

  8. 25 CFR 900.234 - What types of personal conflicts of interest involving tribal officers, employees or...

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What types of personal conflicts of interest involving... ASSISTANCE ACT Conflicts of Interest § 900.234 What types of personal conflicts of interest involving tribal... in which that person has a financial or employment interest that conflicts with that of the trust...

  9. Restraint effect of water infiltration by soil cover types of LLW disposal facility

    International Nuclear Information System (INIS)

    Park, S. M.; Lee, E. Y.; Lee, C. K.; Kim, C. L.

    2002-01-01

    Since soil cover for LLW disposal vault shows quite different restraint effect of water infiltration depending on its type, four different types of soil cover were studied and simulated using HELP code. Simulation result showed that Profile B1 is the most effective type in restraint of water infiltration to the disposal vault. Profile B1 is totally 6m thick and composed of silt, gravelly sand, pea gravel, sand and clayey soil mixed with bentonite 20%. Profile B1 also includes artificial layers, such as asphalt and geomembrane layers. This profile is designed conceptually by NETEC for the soil cover of the near surface disposal facility of the low-level radioactive waste. For comparison, 3 types of different profile were tested. One profile includes bentonite mixed layer only as water barrier layer, or one as same as profile B1 but without geomembrane layer or one without asphalt layer respectively. The simulation using HELP code showed that the water balance in profile B1 was effectively controlled

  10. Interleukin-6 autoantibodies are involved in the pathogenesis of a subset of type 2 diabetes

    DEFF Research Database (Denmark)

    Fosgerau, K; Galle, P; Hansen, T

    2010-01-01

    Interleukin-6 (IL6) is critically involved in inflammation and metabolism. About 1% of people produce IL6 autoantibodies (aAb-IL6) that impair IL6 signaling in vivo. We tested the hypothesis that the prevalence of such aAb-IL6 is increased in type 2 diabetic patients and that aAb-IL6 plays a direct...... role in causing hyperglycemia. In humans, the prevalence of circulating high-affinity neutralizing aAb-IL6 was 2.5% in the type 2 diabetic patients and 1% in the controls (odds ratio 2.5, 95% confidence interval 1.2-4.9, P=0.01). To test for the role of aAb-IL6 in causing hyperglycemia, such aAb-IL6...... were induced in mice by a validated vaccination procedure. Mice with plasma levels of aAb-IL6 similar to the 2.5% type 2 diabetic patients developed obesity and impaired glucose tolerance (area under the curve (AUC) glucose, 2056+/-62 vs 1793+/-62, P=0.05) as compared with sham-vaccinated mice, when...

  11. Renal pathological implications in type 2 diabetes mellitus patients with renal involvement.

    Science.gov (United States)

    Li, Li; Zhang, Xiuhui; Li, Zhicheng; Zhang, Rui; Guo, Ruikun; Yin, Qinghua; Yang, Lichuan; Yue, Rongzheng; Su, Baihai; Huang, Songmin; Xu, Huan; He, Cijiang; Liu, Fang

    2017-01-01

    To investigate the renal pathological implications in type 2 diabetes mellitus patients with renal involvement. A total of 328 type 2 diabetes mellitus (T2DM) patients with renal involvement who underwent a renal biopsy and received follow-up for at least one year were recruited in our study. The patients were divided into the diabetic nephropathy (DN), non-diabetic renal disease (NDRD), and NDRD superimposed on DN groups based on the pathological diagnosis. Renal outcomes were defined by the initiation of renal replacement therapy or doubling of the serum creatinine. Kaplan-Meier analysis was used to compare renal survival, and Cox proportional hazard analysis was used to determine the predictors of renal outcomes in the DN group. Renal biopsy findings revealed that 188 patients (57.32%) had pure DN, 121 patients (36.89%) had NDRD alone, and 19 patients (5.79%) had NDRD superimposed on DN. The most frequent subclassification of NDRD was membranous nephropathy (MN). Compared with the NDRD and NDRD superimposed on DN groups, patients with pure DN had poorer renal function and lower renal survival rates. In the DN group, the five-year renal survival rates of glomerular classes of I, IIa, IIb, III and IV were 100%, 84.62%, 60%, 47.5% and 33.33%, respectively. Multivariate Cox proportional hazard analysis showed that the glomerular lesions, proteinuria and serum creatinine were independent risk factors for renal outcomes, while interstitial fibrosis/inflammation and arteriolar hyalinosis were not independently associated with renal outcomes in the DN group. Making an accurate pathologic diagnosis by renal biopsy is crucial for diabetes mellitus (DM) patients with renal involvement. The findings of our present study indicated that patients with pure DN had poorer renal outcomes than patients with NDRD or NDRD superimposed on DN. The classification of glomerular lesions, proteinuria and serum creatinine were independent risk factors for renal outcomes in the DN group

  12. Public involvement: the critical path in siting controversial facilities. Proceedings of the Nuclear Energy Low-Level Waste Mangement Program conference

    International Nuclear Information System (INIS)

    1986-01-01

    The purpose of the conference was to: exchange information among those responsible for, or interested in, the development of new low-level waste disposal facilities; acquaint participants with past experiences of states and organizations in enfranchising the public in the siting of controversial facilities; and discuss various mechanisms and techniques for effectively involving the public in decision-making processes. The conference addressed four major topics: lessons from past experiences; mechanisms and techniques for public involvement, conflict resolution, and working constructively with the media. A series of presentations on each topic was followed by questions and discussion among presenters and conference participants. Several key points emerged as the conference proceeded

  13. Buffer Construction Methodology in Demonstration Test For Cavern Type Disposal Facility

    International Nuclear Information System (INIS)

    Yoshihiro, Akiyama; Takahiro, Nakajima; Katsuhide, Matsumura; Kenji, Terada; Takao, Tsuboya; Kazuhiro, Onuma; Tadafumi, Fujiwara

    2009-01-01

    A number of studies concerning a cavern type disposal facility have been carried out for disposal of low level radioactive waste mainly generated by power plant decommissioning in Japan. The disposal facility is composed of an engineered barrier system with concrete pit and bentonite buffer, and planed to be constructed in sub-surface 50 - 100 meters depth. Though the previous studies have mainly used laboratory and mock-up tests, we conducted a demonstration test in a full-size cavern. The main objectives of the test were to study the construction methodology and to confirm the quality of the engineered barrier system. The demonstration test was planned as the construction of full scale mock-up. It was focused on a buffer construction test to evaluate the construction methodology and quality control in this paper. Bentonite material was compacted to 1.6 Mg/m 3 in-site by large vibrating roller in this test. Through the construction of the buffer part, a 1.6 Mg/m 3 of the density was accomplished, and the data of workability and quality is collected. (authors)

  14. Declassification of radioactive water from a pool type reactor after nuclear facility dismantling

    Science.gov (United States)

    Arnal, J. M.; Sancho, M.; García-Fayos, B.; Verdú, G.; Serrano, C.; Ruiz-Martínez, J. T.

    2017-09-01

    This work is aimed to the treatment of the radioactive water from a dismantled nuclear facility with an experimental pool type reactor. The main objective of the treatment is to declassify the maximum volume of water and thus decrease the volume of radioactive liquid waste to be managed. In a preliminary stage, simulation of treatment by the combination of reverse osmosis (RO) and evaporation have been performed. Predicted results showed that the combination of membrane and evaporation technologies would result in a volume reduction factor higher than 600. The estimated time to complete the treatment was around 650 h (25-30 days). For different economical and organizational reasons which are explained in this paper, the final treatment of the real waste had to be reduced and only evaporation was applied. The volume reduction factor achieved in the real treatment was around 170, and the time spent for treatment was 194 days.

  15. Evaluation on construction quality of pit filler material of cavern type radioactive waste disposal facility

    International Nuclear Information System (INIS)

    Takechi, Shin-ichi; Yokozeki, Kosuke; Shimbo, Hiroshi; Terada, Kenji; Akiyama, Yoshihiro; Yada, Tsutomu; Tsuji, Yukikazu

    2014-01-01

    The pit filler material of the underground cavern-type radioactive waste disposal facility, which is poured directly around the radioactive waste packages where high temperature environment is assumed by their decay heat, is concerned to be adversely affected on the filling behavior and its hardened properties. There also are specific issues that required quality of construction must be achieved by unmanned construction with remote operation, because the pit filler construction shall be done under radiation environment. In this paper, the mix proportion of filler material is deliberated with filling experiments simulating high temperature environment, and also the effect of temperature on hardened properties are confirmed with high temperature curing test. Subsequently, the feasibility of unmanned construction method of filler material by pumping, and by movable bucket, are comparatively discussed through a real size demonstration. (author)

  16. 2 MeV, 60 kW dual-beam type electron accelerator irradiation facility

    International Nuclear Information System (INIS)

    Yotsumoto, Keiichi; Kanazawa, Takao; Haruyama, Yasuyuki; Agematsu, Takashi; Mizuhashi, Kiyoshi; Sunaga, Hiromi; Washino, Masamitsu; Tamura, Naoyuki

    1984-02-01

    The specification of new irradiation facility which has been constructed from 1978 through 1981 as the replacement of 1st Accelerator of JAERI, TRCRE are described. The accelerator is the Cockcroft-Walton type and both vertical and horizontal accelerating tubes are arranged on a single high voltage generator. Transferring of the high voltage to the horizontal accelerating tube is performed with the high voltage changing system in the pressure vessel. The output ratings of the accelerator are 2 MV of acceleration voltage and 30 mA of beam current. By providing the dual beam system, two irradiation rooms, one for vertical and the other for horizontal beam, are independently operationable. Persons can enter the horizontal irradiation room for experimental setting even when the vertical irradiation room is in operation. The specification of the buildings, the exhaust air treatment system, the irradiation conveyor and the safety observation system are also described. (author)

  17. Facility type and primary care performance in sub-district health promotion hospitals in Northern Thailand.

    Directory of Open Access Journals (Sweden)

    Nithra Kitreerawutiwong

    Full Text Available Poor and middle-income Thai people rely heavily on primary care health services. These are staffed by a range of professionals. However, it is unknown whether the performance of primary care varies according to the staffing and organization of local service delivery units. Tambon (sub-district health promotion hospitals (THPHs were introduced in 2009 to upgrade the services offered by the previous health centres, but were faced with continuing shortages of doctors and nurses. The Ministry of Public Health (MoPH designated three categories of THPH, defined according to whether they were regularly staffed by a medical practitioner, a qualified nurse or non-clinical public health officers. This study aimed to compare the performance of primary care offered by the three different types of primary care facilities in one public health region of Northern Thailand (Public Health Region 2.A cross-sectional survey was undertaken in 2013. Data were collected on accessibility, continuity, comprehensiveness, co-ordination and community orientation of care from 825 patients attending 23 primary care facilities. These were selected to include the three officially-designated types of Tambon (sub-district health promotion hospitals (THPHs led by medical, nursing or public health personnel. Survey scores were compared in unadjusted and adjusted analyses.THPHs staffed only by public health officers achieved the highest performance score (Mean = 85.14, SD. = 7.30, followed by THPHs staffed by qualified nurses (Mean = 82.86, SD. = 7.06. THPHs staffed by a doctor on rotation returned the lowest scores (Mean = 81.63, SD. = 7.22.Differences in overall scores resulted mainly from differences in reported accessibility, continuity, and comprehensiveness of care, rather than staff skill-mix per se. Policy on quality improvement should therefore focus on improving performance in these areas.

  18. Recruitment of mobility limited older adults into a facility-led exercise-nutrition study: the effect of social involvement

    Science.gov (United States)

    Purpose of the Study: Older adults are among the most challenging population groups to enroll into health-related research. This article describes two methods used by investigators to recruit mobility limited older adults residing at assisted living or senior housing (SH) facilities into a facility-...

  19. Demonstration test of underground cavern-type disposal facilities, fiscal 2010 status - 59180

    International Nuclear Information System (INIS)

    Akiyama, Yoshihiro; Terada, Kenji; Oda, Nobuaki; Yada, Tsutomu; Nakajima, Takahiro

    2012-01-01

    A test to demonstrate practical construction technology for underground cavern-type disposal facilities is currently underway. Cavern-type disposal facilities are a radioactive waste repository excavated to a depth of 50 to 100 m below ground and constructed with an engineered barrier system (EBS) that is a combination of low-permeable bentonite material and low-diffusive cementitious material. The disposed materials are low-level radioactive waste with relatively high radioactivity, mainly generated from power reactor decommissioning, and certain transuranic wastes that are mainly generated from spent fuel reprocessing. The project started in fiscal 2005*, and since fiscal 2007 a full-scale mock-up of a disposal facility has been constructed in an actual sub-surface environment. The main objective of the demonstration test is to establish construction procedures and methods which ensure the required quality of an EBS on-site. Certain component parts of the facility had been constructed in an underground cavern by fiscal 2010, and tests so far have demonstrated both the practicability of the construction and the achievement of the required quality. This paper covers the project outline and the test results obtained by the construction of certain EBS components. The following results were obtained from the construction test of EBS in the test cavern: 1) The dry density of bentonite buffer at the lower layer constructed by vibratory compaction shows that 95% of core samples have densities within the target range. 2) The specified mix for the low-diffusion layer has uniform density and crack-control properties, and meets the requirements for diffusion performance. 3) The specified mix of the concrete pit has sufficient passing ability through congested reinforcement and meets the requirements of strength performance. 4) The dry density of the bentonite buffer at the lateral layer constructed by the spraying method shows that 65% of the core samples are within the

  20. 15 years of The Hungarian integral type test facility: horizontal SG related PMK-2 experiments

    International Nuclear Information System (INIS)

    Perneczky, L.; Ezsoel, G.; Guba, A.; Szabados, L.

    2001-01-01

    The PMK-2 experimental facility at the KFKI-AEKI, Budapest, is a full pressure, scaled down model of the primary and partly the secondary circuit of the Paks Nuclear Power Plant. This NPP is equipped with four VVER-440/213-type reactors. Such plants are slightly different from PWRs of usual design and have a number of special features as 6-loop primary circuit, horizontal steam generators, loop seal in hot and cold legs, setpoint pressure of passive safety injection tanks (SIT) higher than secondary pressure, etc. The PMK-2 was primarily designed for investigating operational and off-normal transient processes, as well as small-break loss of coolant accidents of Paks NPP. The volume and power scaling ratios are 1:2070. Due to the importance of gravitational forces in both single- and two-phase flow the elevation ratio is 1:1 except for the lower plenum and pressuriser. The six loops of the plant are modelled by a single active loop. Transients can be started from nominal operating conditions. The pressuriser (PRZ) is connected to the lower part of the hot leg as in the reference system. The core model consists of 19 electrically heated rods. The main circulating pump of the PMK-2 serves to produce the nominal operating conditions and to simulate the flow coast-down following pump trip. The horizontal design of the VVER-440 steam generator is modelled by horizontal heat transfer tubes between hot and cold vertical collectors in the primary side. The emergency core cooling systems including the SITs. High and low pressure injection systems of the Paks NPP are also modelled. The first design of the PMK-NVH facility only modelled the primary circuit of plant. This version was used until 1990. The PMK-2 facility is an upgraded version (first of all by addition of a controlled secondary heat removal system) extending the capability of the test loop to modelling transient processes evoked by initiating events in the secondary circuit or including accident sequences in

  1. Identification of the chemical inventory of different paint types applied in nuclear facilities

    International Nuclear Information System (INIS)

    Sabrina Tietze; Foreman, M.R.St.J.; Ekberg, CH.H.; Chalmers University of Technology, Chemical and Biological Engineering, Goeteborg; Dongen van, B.E.

    2013-01-01

    The floors, concrete walls and many of the metal surfaces in nuclear power plant containments are coated with zinc primers or paint films to preserve the metal surfaces and simplify decontamination in the containment after the occurrence of a severe nuclear incident or accident. A chemical examination of paint films from different nuclear installations out of operation, as well as current operating ones, reveals that different types of paints are used whose composition can vary significantly. Results obtained for one type of paint at a certain nuclear site are in most cases unlikely to be comparable with sites painted with another type of paint. During normal operation and particularly during nuclear accidents, the paints will degrade under the high temperature, steam and irradiation influence. As paint and its degradation products can act as sources and depots for volatile iodine compounds, the type and aging conditions of the paint films will have a significant impact on the source term of the volatile fission product iodine. Thus, great care should be taken when extrapolating any results obtained for the interaction of radioactive iodine with one paint product to a different paint product. The main focus of the study is a comparison of the chemical profile of paint films applied in Swedish nuclear power plants. Teknopox Aqua V A, an epoxy paint recently used at Ringhals 2, and an emulsion paint used in the scrubber buildings of Ringhals 1-4 are compared with a paint film from Barsebaeck nuclear power plant unit 1 that had been aged under real reactor conditions for 20 years. In addition, two paint films, an emulsion and a gloss paint, used in an international nuclear fuel reprocessing facility, are compared with the paints from the Swedish nuclear power plants. (author)

  2. The effects of involvement and ad type on attitudes toward direct-to-consumer advertising of prescription drugs.

    Science.gov (United States)

    Limbu, Yam; Torres, Ivonne M

    2009-01-01

    This article examines consumers' attitudes toward Direct-to-Consumer (DTC) advertising of prescription drugs that are influenced by the use different types of DTC ads and product involvement. Our findings suggest that product involvement and the type of DTC ad are significant predictors of consumers' attitudinal responses toward DTC advertising. High involvement consumers have more favorable attitudes toward the drug's price, DTC ad and brand name, and a higher intention to ask a doctor about the advertised drug than low involvement consumers. In contrast to Informational and Reminder DTC ads, Persuasive ads have more favorable effects on consumers' reactions to DTC prescription drug advertising.

  3. [Surgical treatment and prognosis of Borrmann type IIII( gastric cancer involving the whole stomach].

    Science.gov (United States)

    Dong, Ruizeng; Zhang, Zewei; Zhou, Yiming; Hua, Yonghong; Guo, Jianmin

    2018-02-25

    To explore the surgical treatment and prognosis of Borrmann type IIII( gastric cancer involving the whole stomach. Clinicopathological characteristics and survival data of 223 patients with Borrmann type IIII( gastric cancer involving the whole stomach (defined as the tumor infiltrating 3 regions of the stomach) receiving surgical treatment at the Department of Abdominal Surgery of Zhejiang Cancer Hospital between January 2002 and December 2015 were analyzed retrospectively. The survival time of patients with different clinicopathological features and different treatment methods was compared. Cox regression was used to analyze the independent prognostic factors. Two hundred and twenty-three patients with Borrmann type IIII( gastric cancer involving the whole stomach accounted for 24.0% (223/930) of all Borrmann type IIII( gastric cancer cases undergoing surgical resection at the same period. There were 147 males and 76 females with an average age of 57.8 years. All the patients underwent total gastrectomy. Of these patients, radical resection was performed in 149 cases(66.8%) and palliative resection in 74 cases (33.2%). Combined organ resection was performed in 43 patients (19.3%), including 25 splenectomies, 6 pancreatic body and tail plus spleen and transverse colon resections, 2 transverse colon plus spleen resections, 2 right colon resections, 2 transverse colon resections, 2 ovariectomies, 1 partial jejunal resection, 1 pancreatoduodenectomy, 1 pancreatic tail plus transverse colon resection, and 1 partial pancreatectomy. Postoperative complications occurred in 28 patients(12.6%), including 10 patients with combined organ resection. Esophagojejunal fistula was the most frequent complication, accounting for 39.3%(11/28). Perioperative mortality occurred in 3 patients (1.3%). Thirty-nine patients underwent preoperative adjuvant chemotherapy (clinical stage: cT4aN0M0 in 1 patient, cT4bN1-2M0 in 12 patients, cT4aN1-2M0 in 20 patients, and cT4aN3M0 in 6 patients

  4. Huff-type competitive facility location model with foresight in a discrete space

    OpenAIRE

    Milad Gorji Ashtiani; Ahmad Makui; Reza Ramezanian

    2011-01-01

    Consider a chain as leader that wants to open p new facilities in a linear market, like metro. In this market, there is a competitor, called follower. The leader and the follower have established some facilities in advance. When the leader opens p new facilities, its competitor, follower, reacts the leader’s action and opens r new facilities. The optimal locations for leader and follower are chosen among predefined potential locations. Demand is considered as demand points and is assumed inel...

  5. Image quality of mammography in Croatian nationwide screening program: Comparison between various types of facilities

    International Nuclear Information System (INIS)

    Brnić, Zoran; Blašković, Darko; Klasić, Branimir; Ramač, Jelena Popić; Flegarić-Bradić, Mirjana; Štimac, Damir; Lubina, Ivan Zvonimir; Brnić, Vedran; Faj, Dario

    2012-01-01

    Purpose: The study was aimed to provide objective evidence about the mammographic image quality in Croatia, to compare it between different types of MG facilities and to identify the most common deficiencies and possible reasons as well as the steps needed to improve image quality. Materials and methods: A total of 420 mammographic examinations collected from 84 mammographic units participating in the Croatian nationwide breast cancer screening program were reviewed in terms of four image quality categories: identification of patient and examination, breast positioning and compression, exposure and contrast, and artifacts. Those were rated using image evaluating system based on American College of Radiology and European Commission proposals. The results were compared among different types of mammographic units, and common image quality deficiencies were identified. Results: Total image quality scores of 12.8, 16.1, 13.0 and 13.7 were found for general hospitals, university hospitals, private clinics and public healthcare centres, respectively. Average score for all mammographic units was 13.5 (out of 25 points). University hospitals were significantly better than all other mammography units in overall image quality, which was mostly contributed by better breast positioning practices. Private clinics showed the worst results in identification, exposure, contrast and artifacts. Conclusions: Serious deficiencies in identification and breast positioning, which might compromise breast cancer screening outcome, were detected in our material. They occur mainly due to subjective reasons and could be corrected through additional staff training and improvement of working discipline.

  6. Cherenkov-type diagnostics of fast electrons beams escaping from MCF facilities

    Energy Technology Data Exchange (ETDEWEB)

    Jakubowski, L.; Malinowski, K.; Mirowski, R.; Rabinski, M.; Sadowski, M.J.; Zebrowski, J. [Institute for Nuclear Studies - IPJ, 05-400 Otwock-Swierk (Poland)

    2011-07-01

    The paper presents the feasibility study, the measuring system and the first experimental results of a new method developed for direct detection of high-energy (super-thermal, ripple-born and runaway) electrons generated in magnetic confinement fusion (MCF) facilities. The technique in question is based on registration of the Cherenkov radiation, emitted by energetic electrons, moving through a transparent medium (radiator) with a velocity higher than the velocity of light in this material. The main aim of our studies was to develop a diagnostic technique applicable for measurements of fast electron beams within MCF devices. The IPJ team proposed Cherenkov-type probes because of their high spatial- and temporal-resolutions. The most important results of applications of the presented Cherenkov-type diagnostics have proved that the one- and four-channel versions of the detecting head are useful for studies of the fast (ripple-born and runaway) electrons in different MCF experiments. Experience collected during the described studies allows to introduce some changes in the radiator configuration and to modify the Cherenkov probe design. This document is composed of a paper followed by a poster

  7. Recruitment of Mobility Limited Older Adults Into a Facility-Led Exercise-Nutrition Study: The Effect of Social Involvement.

    Science.gov (United States)

    Corcoran, Michael P; Nelson, Miriam E; Sacheck, Jennifer M; Reid, Kieran F; Kirn, Dylan; Fielding, Roger A; Folta, Sara C

    2016-08-01

    Older adults are among the most challenging population groups to enroll into health-related research. This article describes two methods used by investigators to recruit mobility limited older adults residing at assisted living or senior housing (SH) facilities into a facility-led exercise-nutrition research study. Sedentary older adults were recruited from 42 different assisted living facilities (ALFs) or SH communities. Two different recruitment approaches were used: At 22 sites, investigators conducted heavily advertised informational sessions to recruit participants (Info only). At 20 locations, these sessions were preceded by attendance of a study team member at various activities offered by the facility over the preceding 2 weeks (activity attendance). Population reach, enrollment, personnel cost, and time required to recruit at least five participants at each facility was measured. Reasons for declining participation and withdrawal rate were also measured. Sixty percent more residents elected to be screened for eligibility when study personnel attended an activity offered by the facility. Activity attendance resulted in significantly less time, costs, and participant withdrawals compared with facilities with no activity attendance. Study team member attendance at activities offered by senior living facilities reduces cost and duration of recruitment and improves study retention. Interventions targeting this demographic are likely to benefit from deliberately building trust and familiarity among the resident population at senior living communities as part of the recruitment process. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  8. WWER type reactor primary loop imitation on large test loop facility in MARIA reactor

    International Nuclear Information System (INIS)

    Moldysh, A.; Strupchevski, A.; Kmetek, Eh.; Spasskov, V.P.; Shumskij, A.M.

    1982-01-01

    At present in Poland in cooperation with USSR a nuclear water loop test facility (WL) in 'MARIA' reactor in Sverke is under construction. The program objective is to investigate processes occuring in WWER reactor under emergency conditions, first of all after the break of the mainprimary loop circulation pipe-line. WL with the power of about 600 kW consists of three major parts: 1) an active loop, imitating the undamaged loops of the WWER reactor; 2) a passive loop assignedfor modelling the broken loop of the WWER reactor; 3) the emergency core cooling system imitating the corresponding full-scale system. The fuel rod bundle consists of 18 1 m long rods. They were fabricated according to the standard WWER fuel technology. In the report some general principles of WWERbehaviour imitation under emergency conditions are given. They are based on the operation experience obtained from 'SEMISCALE' and 'LOFT' test facilities in the USA. A description of separate modelling factors and criteria effects on the development of 'LOCA'-type accident is presented (the break cross-section to the primary loop volume ratio, the pressure differential between inlet and outlet reactor chambers, the pressure drop rate in the loop, the coolant flow rate throuh the core etc.). As an example a comparison of calculated flow rate variations for the WWER-1000 reactor and the model during the loss-of-coolant accident with the main pipe-line break at the core inlet is given. Calculations have been carried out with the use of TECH'-M code [ru

  9. Ownership type and team climate in elderly care facilities: the moderating effect of stress factors.

    Science.gov (United States)

    Heponiemi, Tarja; Elovainio, Marko; Kouvonen, Anne; Noro, Anja; Finne-Soveri, Harriet; Sinervo, Timo

    2012-03-01

    This paper is a report of a study examining the association between ownership type and perceived team climate among older people care staff. In addition, we examined whether work stress factors (time pressure, resident-related stress, role conflicts and role ambiguity) mediated or moderated the above mentioned association. There has been a trend towards contracting out in older people care facilities in Finland and the number of private for-profit firms has increased. Studies suggest that there may be differences in employee well-being and quality of care according to the ownership type of older people care. Cross-sectional survey data was collected during the autumn of 2007 from 1084 Finnish female older people care staff aged 18-69 years were used. Team Climate Inventory was used to measure team climate. Ownership type was divided into four categories: for-profit sheltered homes, not-for-profit sheltered homes, public sheltered homes and not-for-profit nursing homes. Analyses of covariance were used to examine the associations. Team climate dimensions participative safety, vision and support for innovation were higher in not-for-profit organizations (both sheltered homes and nursing homes) compared to for-profit sheltered homes and public sheltered homes. Stress factors did not account for these associations but acted as moderators in a way that in terms of task orientation and participative safety employees working in for-profit organizations seemed to be slightly more sensitive to work-related stress than others. Our results suggest that for-profit organizations and public organizations may have difficulties in maintaining their team climate. In consequence, these organizations should focus more effort on improving their team climate. © 2011 Blackwell Publishing Ltd.

  10. Morphine biosynthesis in opium poppy involves two cell types: sieve elements and laticifers.

    Science.gov (United States)

    Onoyovwe, Akpevwe; Hagel, Jillian M; Chen, Xue; Khan, Morgan F; Schriemer, David C; Facchini, Peter J

    2013-10-01

    Immunofluorescence labeling and shotgun proteomics were used to establish the cell type-specific localization of morphine biosynthesis in opium poppy (Papaver somniferum). Polyclonal antibodies for each of six enzymes involved in converting (R)-reticuline to morphine detected corresponding antigens in sieve elements of the phloem, as described previously for all upstream enzymes transforming (S)-norcoclaurine to (S)-reticuline. Validated shotgun proteomics performed on whole-stem and latex total protein extracts generated 2031 and 830 distinct protein families, respectively. Proteins corresponding to nine morphine biosynthetic enzymes were represented in the whole stem, whereas only four of the final five pathway enzymes were detected in the latex. Salutaridine synthase was detected in the whole stem, but not in the latex subproteome. The final three enzymes converting thebaine to morphine were among the most abundant active latex proteins despite a limited occurrence in laticifers suggested by immunofluorescence labeling. Multiple charge isoforms of two key O-demethylases in the latex were revealed by two-dimensional immunoblot analysis. Salutaridine biosynthesis appears to occur only in sieve elements, whereas conversion of thebaine to morphine is predominant in adjacent laticifers, which contain morphine-rich latex. Complementary use of immunofluorescence labeling and shotgun proteomics has substantially resolved the cellular localization of morphine biosynthesis in opium poppy.

  11. KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression.

    Science.gov (United States)

    Fujita, Yuji; Masuda, Kiyoshi; Hamada, Junichi; Shoda, Katsutoshi; Naruto, Takuya; Hamada, Satoshi; Miyakami, Yuko; Kohmoto, Tomohiro; Watanabe, Miki; Takahashi, Rizu; Tange, Shoichiro; Saito, Masako; Kudo, Yasusei; Fujiwara, Hitoshi; Ichikawa, Daisuke; Tangoku, Akira; Otsuji, Eigo; Imoto, Issei

    2017-11-24

    KH-type splicing regulatory protein (KHSRP) is a multifunctional RNA-binding protein, which is involved in several post-transcriptional aspects of RNA metabolism, including microRNA (miRNA) biogenesis. It affects distinct cell functions in different tissues and can have an impact on various pathological conditions. In the present study, we investigated the oncogenic functions of KHSRP and their underlying mechanisms in the pathogenesis of esophageal squamous cell carcinoma (ESCC). KHSRP expression levels were elevated in ESCC tumors when compared with those in non-tumorous tissues by immunohistochemistry, and cytoplasmic KHSRP overexpression was found to be an independent prognosticator for worse overall survival in a cohort of 104 patients with ESCC. KHSRP knockdown inhibited growth, migration, and invasion of ESCC cells. KHSRP knockdown also inhibited the maturation of cancer-associated miRNAs, such as miR-21, miR-130b, and miR-301, and induced the expression of their target mRNAs, such as BMP6, PDCD4, and TIMP3, resulting in the inhibition of epithelial-to-mesenchymal transition. Our findings uncover a novel oncogenic function of KHSRP in esophageal tumorigenesis and implicate its use as a marker for prognostic evaluation and as a putative therapeutic target in ESCC.

  12. Evidence for the involvement of cofilin in Aspergillus fumigatus internalization into type II alveolar epithelial cells.

    Science.gov (United States)

    Bao, Zhiyao; Han, Xuelin; Chen, Fangyan; Jia, Xiaodong; Zhao, Jingya; Zhang, Changjian; Yong, Chen; Tian, Shuguang; Zhou, Xin; Han, Li

    2015-08-13

    The internalization of Aspergillus fumigatus into alveolar epithelial cells (AECs) is tightly controlled by host cellular actin dynamics, which require close modulation of the ADF (actin depolymerizing factor)/cofilin family. However, the role of cofilin in A. fumigatus internalization into AECs remains unclear. Here, we demonstrated that germinated A. fumigatus conidia were able to induce phosphorylation of cofilin in A549 cells during the early stage of internalization. The modulation of cofilin activity by overexpression, knockdown, or mutation of the cofilin gene in A549 cells decreased the efficacy of A. fumigatus internalization. Reducing the phosphorylation status of cofilin with BMS-5 (LIM kinase inhibitor) or overexpression of the slingshot phosphatases also impeded A. fumigatus internalization. Both the C. botulimun C3 transferase (a specific RhoA inhibitor) and Y27632 (a specific ROCK inhibitor) reduced the internalization of A. fumigatus and the level of phosphorylated cofilin. β-1,3-glucan (the major component of the conidial cell wall) and its host cell receptor dectin-1 did not seem to be associated with cofilin phosphorylation during A. fumigatus infection. These results indicated that cofilin might be involved in the modulation of A. fumigatus internalization into type II alveolar epithelial cells through the RhoA-ROCK-LIM kinase pathway.

  13. A waterborne outbreak involving hepatitis A virus genotype IA at a residential facility in the Republic of Korea in 2015.

    Science.gov (United States)

    Shin, Eunkyung; Kim, Jin Seok; Oh, Kyung-Hwan; Oh, Sung Suck; Kwon, MunJu; Kim, Soojin; Park, Jungsun; Kwak, Hyo-Sun; Chung, Gyung Tae; Kim, Chul-Joong; Kim, Junyoung

    2017-09-01

    Hepatitis A virus (HAV), a major cause of acute hepatitis, has had the highest occurrence among group 1 nationally notifiable infectious diseases in Korea since 2010.Recently,the annual increase in the HAV infection rate among young adults has become a public health concern. The aim of this study was to describe an outbreak of acute hepatitis in a residential facility in April 2015 and to identify potential sources of this outbreak. Sera from all exposed residents were tested for anti-HAV IgM or IgG antibodies by ELISA. Clinical (sera and stool) and environmental samples were screened for the presence of HAV RNA using one-step RT-PCR and nested PCR. The VP3-VP1 regions of HAV were analyzed using the BLAST database and MEGA7 software. Of the 82 persons in the facility, 12 (14.6%, including 10 residents and 2 health care workers) were diagnosed with hepatitis A. Clinical symptoms were evident in 9 individuals, one of whom died, and the remaining four patients were asymptomatic. Traceback investigation revealed that HAV-RNA (genotype IA) was detected in the patients' stools and the groundwater used in the facility. We described an HAV outbreak in a facility for the disabled due to using a water supply that was mixed with contaminated groundwater. Therefore, HAV vaccination and periodic water inspections in group facilities should be emphasized to prevent HAV infection. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. 25 CFR 1000.463 - What types of personal conflicts of interest involving tribal officers, employees or...

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What types of personal conflicts of interest involving...-DETERMINATION AND EDUCATION ACT Conflicts of Interest § 1000.463 What types of personal conflicts of interest... financial or employment interest that conflicts with that of the trust beneficiary, whether the tribe...

  15. The Dark Triad and three types of jealousy : Its’ relations among heterosexuals and homosexuals involved in a romantic relationship

    NARCIS (Netherlands)

    Barelds, Dick P.H.; Dijkstra, Pieternel; Groothof, Hinke A.K.; Pastoor, Charlotte D.

    2017-01-01

    The current study examined the relations between the three Dark Triad (DT) traits and three types of jealousy, among both heterosexual and homosexual men and women involved in a romantic relationship (n = 439). It was hypothesized that the three DT traits would be related positively to those types

  16. Examining the interaction of parental involvement and parenting style in predicting adherence in youth with type 1 diabetes.

    Science.gov (United States)

    Landers, Sara E; Friedrich, Elizabeth A; Jawad, Abbas F; Miller, Victoria A

    2016-03-01

    This study examined whether aspects of parenting style (specifically, warmth, autonomy support, and coercion) moderated the association between parental involvement and adherence in youth with type 1 diabetes. Children ages 8 to 16 years with type 1 diabetes and a parent completed assessments of parental involvement, parenting style, and adherence. Parent autonomy support and coercion were associated with adherence but warmth was not. Child report of more parental involvement was associated with better adherence. Warmth, autonomy support, and coercion were not moderators. The findings underscore the importance of parental involvement, operationalized as responsibility for diabetes tasks, and parenting style, specifically coercion and autonomy support, for adherence in pediatric chronic illness management. Longitudinal research is needed to better understand how and why dimensions of involvement (e.g., responsibility, monitoring, support) vary over time and whether they impact outcomes differentially. (PsycINFO Database Record (c) 2016 APA, all rights reserved).

  17. Experiments in LEENA facility with modified wire type leak detector layout in large sodium pipelines

    International Nuclear Information System (INIS)

    Vijayakumar, G.; Chandramouli, S.; Nashine, B.K.; Selvaraj, P.; Rajan, K.K.

    2017-01-01

    Highlights: • FBR large horizontal secondary pipeline were simulated and five sodium leak experiments were conducted by providing modified wire type leak detector layout at 550 °C. • Early detection of sodium leak is needed for minimizing the sodium leaked out and consequent damages. • PFBR leak detector layout on large horizontal pipelines can detect a leak rate of 200 g/h within 6 h. • By reducing the distance between leak point and detector to half, detection time was reduced to 1/6th and found that a leak rate of 200 g/h can be detected in one hour. • A relationship between leak rate and detection time was established based on experimental results. - Abstract: Sodium cooled Fast Breeder Reactors (SFRs) are envisaged in the second phase of Indian nuclear power programme. Liquid sodium is used as the coolant in the SFRs due to its favourable nuclear properties and excellent heat transfer properties. Leaks in sodium systems have the potential of being exceptionally hazardous due to the reaction of liquid sodium with oxygen and water vapour in the air. When a sodium leak occurs, the sodium leak rate, the total quantity of sodium leaked and leak detector layout governs the detection time. Other factors to be considered are insulation material packing condition, distance between the leak point and detector, heater layout, pipe geometry, temperature etc. Potential regions of leakage in Fast Breeder Reactor (FBR) sodium circuits are near welds, high stress areas and regions subjected to thermal striping. Early detection of leak is needed for minimizing the quantity of sodium leaked to outside and consequent damages. Three wire type leak detectors (WLDs positioned at 90°, 180° and 270°) working on conductivity principle are used for detecting sodium leak in the large horizontal secondary sodium pipelines of Prototype Fast Breeder Reactor (PFBR). It was found from the upper boundary curve based on LEENA (LEak Experiments in NAtrium) facility experimental

  18. Incidence, types and characteristics of aggressive behaviour in treatment facilities for adults with mild intellectual disability and severe challenging behaviour

    NARCIS (Netherlands)

    Tenneij, N.H.; Koot, H.M.

    2008-01-01

    Background: Inpatient aggression in treatment facilities for persons with intellectual disability (ID) can have aversive consequences, for co-clients and staff, but also for the aggressors themselves. To manage and eventually prevent inpatient aggressive incidents, more knowledge about their types

  19. Existence principles for inclusions of Hammerstein type involving noncompact acyclic multivalued maps

    Directory of Open Access Journals (Sweden)

    Jean-Francois Couchouron

    2002-01-01

    Full Text Available We apply Monch type fixed point theorems for acyclic multivalued maps to the solvability of inclusions of Hammerstein type in Banach spaces. Our approach makes possible to unify and improve the existence theories for nonlinear evolution problems and abstract integral inclusions of Volterra and Fredholm type.

  20. Szász-Durrmeyer operators involving Boas-Buck polynomials of blending type.

    Science.gov (United States)

    Sidharth, Manjari; Agrawal, P N; Araci, Serkan

    2017-01-01

    The present paper introduces the Szász-Durrmeyer type operators based on Boas-Buck type polynomials which include Brenke type polynomials, Sheffer polynomials and Appell polynomials considered by Sucu et al. (Abstr. Appl. Anal. 2012:680340, 2012). We establish the moments of the operator and a Voronvskaja type asymptotic theorem and then proceed to studying the convergence of the operators with the help of Lipschitz type space and weighted modulus of continuity. Next, we obtain a direct approximation theorem with the aid of unified Ditzian-Totik modulus of smoothness. Furthermore, we study the approximation of functions whose derivatives are locally of bounded variation.

  1. Szász-Durrmeyer operators involving Boas-Buck polynomials of blending type

    Directory of Open Access Journals (Sweden)

    Manjari Sidharth

    2017-05-01

    Full Text Available Abstract The present paper introduces the Szász-Durrmeyer type operators based on Boas-Buck type polynomials which include Brenke type polynomials, Sheffer polynomials and Appell polynomials considered by Sucu et al. (Abstr. Appl. Anal. 2012:680340, 2012. We establish the moments of the operator and a Voronvskaja type asymptotic theorem and then proceed to studying the convergence of the operators with the help of Lipschitz type space and weighted modulus of continuity. Next, we obtain a direct approximation theorem with the aid of unified Ditzian-Totik modulus of smoothness. Furthermore, we study the approximation of functions whose derivatives are locally of bounded variation.

  2. Huff-type competitive facility location model with foresight in a discrete space

    Directory of Open Access Journals (Sweden)

    Milad Gorji Ashtiani

    2011-01-01

    Full Text Available Consider a chain as leader that wants to open p new facilities in a linear market, like metro. In this market, there is a competitor, called follower. The leader and the follower have established some facilities in advance. When the leader opens p new facilities, its competitor, follower, reacts the leader’s action and opens r new facilities. The optimal locations for leader and follower are chosen among predefined potential locations. Demand is considered as demand points and is assumed inelastic. Considering huff model, demand points are probabilistically absorbed by all facilities. The leader’s objective is maximization of its market share after opening follower’s new facilities. For solving leader problem, first the follower’s problem is solved for all leader’s potential locations and the best location for leader is obtained and then, a heuristic model is proposed for leader problem when the leader and the follower want to open one new facility. Computational results show that the proposed method is efficient for large scale problems.

  3. A Study on the Ion Beam Extraction using Duo-PiGatron Ion source for Vertical Type Ion Beam Facility

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bom Sok; Lee, Chan young; Lee, Jae Sang [KAERI, Daejeon (Korea, Republic of)

    2015-05-15

    In Korea Multipurpose Accelerator Complex (KOMAC), we have started ion beam service in the new beam utilization building since March this year. For various ion beam irradiation services, we are developed implanters such as metal (150keV/1mA), gaseous (200keV/5mA) and high current ion beam facility (20keV/150mA). One of the new one is a vertical type ion beam facility without acceleration tube (60keV/20mA) which is easy to install the sample. After the installation is complete, it is where you are studying the optimal ion beam extraction process. Detailed experimental results will be presented. Vertical Type Ion Beam Facility without acceleration tube of 60keV 20mA class was installed. We successfully extracted 60keV 20mA using Duo- PiGatron Ion source for Vertical Type Ion Beam Facility. Use the BPM and Faraday-cup, is being studied the optimum conditions of ion beam extraction.

  4. Application of an experimental irradiation facility type K-120 for the radiation treatment of agricultural products in large quantity

    International Nuclear Information System (INIS)

    Stenger, V.; Foeldiak, G.; Horvath, I.; Hargittai, P.; Bartfai, Cs.

    1979-01-01

    During experimental and pilot irradiation carried out by the 60 Co irradiation facility type K-120 of the Institute of Isotopes of the Hungarian Academy of Sciences an irradiation technology for the treatment of agricultural and food products of considerable density has been developed. Applying transport containers of commercial size the intermittent radiation treatment of great quantity products was made possible with homogeneous dose distribution. The radiation technical characteristics, the utilization coefficient and the capacity of the facility for every agricultural product were calculated. (author)

  5. Updating expected action outcome in the medial frontal cortex involves an evaluation of error type.

    Science.gov (United States)

    Maier, Martin E; Steinhauser, Marco

    2013-10-02

    Forming expectations about the outcome of an action is an important prerequisite for action control and reinforcement learning in the human brain. The medial frontal cortex (MFC) has been shown to play an important role in the representation of outcome expectations, particularly when an update of expected outcome becomes necessary because an error is detected. However, error detection alone is not always sufficient to compute expected outcome because errors can occur in various ways and different types of errors may be associated with different outcomes. In the present study, we therefore investigate whether updating expected outcome in the human MFC is based on an evaluation of error type. Our approach was to consider an electrophysiological correlate of MFC activity on errors, the error-related negativity (Ne/ERN), in a task in which two types of errors could occur. Because the two error types were associated with different amounts of monetary loss, updating expected outcomes on error trials required an evaluation of error type. Our data revealed a pattern of Ne/ERN amplitudes that closely mirrored the amount of monetary loss associated with each error type, suggesting that outcome expectations are updated based on an evaluation of error type. We propose that this is achieved by a proactive evaluation process that anticipates error types by continuously monitoring error sources or by dynamically representing possible response-outcome relations.

  6. Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors

    NARCIS (Netherlands)

    Verhaagh, S.; Jong, E. de; Goudsmit, J.; Lecollinet, S.; Gillissen, G.; Vries, M. de; Leuven, K. van; Que, I.; Ouwehand, K.; Mintardjo, R.; Weverling, G.J.; Radošević, K.; Richardson, J.; Eloit, M.; Lowik, C.; Quax, P.; Havenga, M.

    2006-01-01

    Wild-type strains of mice do not express CD46, a high-affinity receptor for human group B adenoviruses including type 35. Therefore, studies performed to date in mice using replication-incompetent Ad35 (rAd35) vaccine carriers may underestimate potency or result in altered vector distribution. Here,

  7. Primary NK/T cell lymphoma nasal type of the stomach with skin involvement: a case report

    Directory of Open Access Journals (Sweden)

    Sebastian Kobold

    2009-12-01

    Full Text Available Since nasal NK/T cell lymphoma and NK/T cell lymphoma nasal type are rare diseases, gastric involvement has seldom been seen. We report a unique case of a patient with a primary NK/T cell lymphoma nasal type of the stomach with skin involvement. The patient had no history of malignant diseases and was diagnosed with hematemesis and intense bleeding from his gastric primary site. Shortly after this event, exanthemic skin lesions appeared with concordant histology to the primary site. Despite chemotherapy, the patient died one month after the first symptomatic appearance of disease.

  8. Biochemical mechanisms involved in the endotoxin-induced type II cell hyperplasia in F344 rat lung

    International Nuclear Information System (INIS)

    Tesfaigzi, J.; Johnson, N.F.; Lechner, J.F.

    1994-01-01

    Proliferative lesions and pulmonary epithelial neoplasms induced in the rat by plutonium inhalation have been shown to be of type II cell origin. Defining the gene changes responsible for the development of the type II proliferative lesions would help to elucidate the genetic events involved in the expansion of initiated type II cells into fully transformed tumor cells. One problem in identifying these gene alterations is dissociating changes in gene expression linked to cell replication or repair from those involved in tumor initiation and progression. The long-term goals of these investigations are to first develop and characterize a model of transient type II cell hyperplasia. Second, changes in gene expression associated with remodeling epithelium will be compared to gene changes exhibited by the 239 Pu-induced hyperplastic lesions

  9. Helmholtz and Diffusion Equations Associated with Local Fractional Derivative Operators Involving the Cantorian and Cantor-Type Cylindrical Coordinates

    Directory of Open Access Journals (Sweden)

    Ya-Juan Hao

    2013-01-01

    Full Text Available The main object of this paper is to investigate the Helmholtz and diffusion equations on the Cantor sets involving local fractional derivative operators. The Cantor-type cylindrical-coordinate method is applied to handle the corresponding local fractional differential equations. Two illustrative examples for the Helmholtz and diffusion equations on the Cantor sets are shown by making use of the Cantorian and Cantor-type cylindrical coordinates.

  10. A novel mechanism of P-type ATPase autoinhibition involving both termini of the protein

    DEFF Research Database (Denmark)

    Ekberg, Kira; Palmgren, Michael; Veierskov, Bjarke

    2010-01-01

    The activity of many P-type ATPases is found to be regulated by interacting proteins or autoinhibitory elements located in N- or C-terminal extensions. An extended C terminus of fungal and plant P-type plasma membrane H+-ATPases has long been recognized to be part of a regulatory apparatus....... This identifies the first group of P-type ATPases for which both ends of the polypeptide chain constitute regulatory domains, which together contribute to the autoinhibitory apparatus. This suggests an intricate mechanism of cis-regulation with both termini of the protein communicating to obtain the necessary...

  11. Familial disseminated plaque type porokeratosis with multiple horns and squamous cell carcinoma involving anal skin

    Directory of Open Access Journals (Sweden)

    Sarma Nilendu

    2009-01-01

    Full Text Available Porokeratosis is a disorder of keratinization showing a well-defined lesion with a hyperkeratotic ridge on the border that contains the coronoid lamella. We report familial (autosomal dominant with reduced penetrance disseminated plaque type (Mibelli′s type porokeratosis in a father and son. In the father, there were multiple horns and a large squamous cell carcinoma in a large lesion over the perianal region that reached up to the squamo-columnar junction of the anal mucosa and even invaded the anal sphincteric muscles. Disseminated lesions of the Mibelli′s type, development of horns, and malignancy in this unusual location have not been previously reported.

  12. Inapparent lung involvement in patients with the subacute juvenile type of paracoccidioidomycosis

    Directory of Open Access Journals (Sweden)

    A. Restrepo

    1989-02-01

    Full Text Available Three patients with the diagnosis of subacute juvenile paracoccidioidomycosis who, at the time of their first visit, had no signs or symptoms of lung involvement, were studied. Initially the diagnosis was confirmed by the observation of P. brasiliensis in biopsy material obtained from clinically involved lymphadenopathies. The lung X-rays done in all patients, did not reveal pathologic changes, although it was possible to observe and isolate the fungus from sputum samples obtained from the three patients. This fact reinforces the pulmonary genesis of the mycosis and proofs the existence of a pulmonary primary infection, even in patients with the juvenile manifestations, in whom the lung component is obscured by the predominant lymph node involvement.

  13. The Types of Trust Involved in American Muslim Healthcare Decisions: An Exploratory Qualitative Study.

    Science.gov (United States)

    Padela, Aasim I; Pruitt, Liese; Mallick, Saleha

    2017-08-01

    Trust in physicians and the healthcare system underlies some disparities noted among minority populations, yet a descriptive typology of different types of trust informing healthcare decisions among minority populations is limited. Using data from 13 focus groups with 102 American Muslims, we identified the types and influence of trust in healthcare decision-making. Participants conveyed four types of trust implicating their health-seeking behaviors-(I) trust in allopathic medicine, (II) trust in God, (III) trust in personal relationships, and (IV) trust in self. Healthcare disparity research can benefit from assessing how these types of trust are associated with health outcomes among minority populations so as to inform intervention programs that seek to enhance trust as a means to improve community health.

  14. Being Involved in the Country: Productive Ageing in Different Types of Rural Communities

    Science.gov (United States)

    Davis, Sandra; Crothers, Natalie; Grant, Jeanette; Young, Sari; Smith, Karly

    2012-01-01

    Productive ageing recognises the contribution of older people to economic, social and cultural growth and helps build a sustainable community. Being involved in community life is good for individuals and good for society. However, we know very little about the participation of and contribution by people aged 50 and over in rural communities. This…

  15. Emission Facilities - Erosion & Sediment Control Facilities

    Data.gov (United States)

    NSGIC Education | GIS Inventory — An Erosion and Sediment Control Facility is a DEP primary facility type related to the Water Pollution Control program. The following sub-facility types related to...

  16. Disclosing Brand Placements in Movies : Effects of Disclosure Type and Movie Involvement on Attitudes

    NARCIS (Netherlands)

    van Reijmersdal, E.A.

    2016-01-01

    Recently, the European Union has decided that disclosures of brand placement are obligatory. However, the effects of such disclosures remain largely unstudied. Departing from theoretical notions of the persuasion knowledge model, this study examined how different types of disclosures and viewer

  17. Hand involvement in children with Charcot-Marie-Tooth disease type 1A

    NARCIS (Netherlands)

    Burns, Joshua; Bray, Paula; Cross, Lauren A.; North, Kathryn N.; Ryan, Monique M.; Ouvrier, Robert A.

    2008-01-01

    Charcot-Marie-Tooth disease type 1A (CMT1A), a demyelinating neuropathy characterised by progressive length-dependent muscle weakness and atrophy, is thought to affect the foot and leg first followed some time later by hand weakness and dysfunction. We aimed to characterise hand Strength, function

  18. [Prevalence of renal involvement in a population of type Ii diabetics followed up in primary care].

    Science.gov (United States)

    Marín, R; Coca, A; Tranche, S; Rodríguez Mañas, L; Abellán, J; Moyá, A

    2002-01-01

    Patients with type 2 diabetes use to be managed in their primary care settings during the early stages of the disease. The main objective of the study was to determine renal impairment prevalence, and to assess its significance, within type 2 diabetics controlled by their family physicians. Transverse observation of patients with type 2 diabetes who were the first 20 unselected cases seen by 183 family physicians from 16 of the 17 Autonomic Communities of our country. The following variables were determined: serum creatinine, glucose, and HbA1c concentrations, proteinuria (dipstick test in a first-voided morning urine sample), blood pressure levels, and associated cardiovascular disease. Data from 3,583 type 2 diabetic subjects were evaluated. Mean age was 64 +/- 10 years and 45% were male. A serum creatinine > or = 1.2 mg/dl was observed in 523 (15.5%) patients. Proteinuria was present in 794 (23.5%) cases, being > or = 2 + in 215 (6.5%) subjects. Patients with a serum creatinine > or = 1.2 mg/dl were older, shower higher blood pressure levels, and suffered from more cardiovascular disease (32.0 vs 19.5%) than those with a serum creatinine or = 2 + proteinuria (p or = 140/90 mmHg in 69% of the cases, being < 130/85 mmHg in only 8% of the subjects. There is a high prevalence of renal impairment, approximately of 25% within type 2 diabetic patients seen at the primary care level. Optimal blood pressure level seems to be extremely infrequent bearing in mind the diagnosis of diabetes and the associated cardiovascular disease.

  19. The Inter Facility Testing of a Standard Oscillating Water Column (OWC) Type Wave Energy Converter (WEC)

    DEFF Research Database (Denmark)

    Andersen, Morten Thøtt; Thomsen, Jonas Bjerg

    This report describes the behavior and preliminary performance of a simplified standard oscillating water column (OWC) wave energy converter (WEC). The same tests will be conducted at different scales at 6 different test facilities and the results obtained will be used for comparison. This project...

  20. Reinforced aortic root reconstruction for acute type A aortic dissection involving the aortic root

    Directory of Open Access Journals (Sweden)

    Han Qing-qi

    2013-06-01

    Full Text Available OBJECTIVE: There are debates regarding the optimal approach for AAAD involving the aortic root. We described a modified reinforced aortic root reconstruction approach for treating AAAD involving the aortic root. METHODS: A total of 161 patients with AAAD involving the aortic root were treated by our modified reinforced aortic root reconstruction approach from January 1998 to December 2008. Key features of our modified approach were placement of an autologous pericardial patch in the false lumen, lining of the sinotubular junction lumen with a polyester vascular ring, and wrapping of the vessel with Teflon strips. Outcome measures included post-operative mortality, survival, complications, and level of aortic regurgitation. RESULTS: A total of 161 patients were included in the study (mean age: 43.3 1 15.5 years. The mean duration of follow-up was 5.1 1 2.96 years (2-12 years. A total of 10 (6.2% and 11 (6.8% patients died during hospitalization and during follow-up, respectively. Thirty-one (19.3% patients experienced postoperative complications. The 1-, 3-, 5-, and 10-year survival rates were 99.3%, 98%, 93.8%, and 75.5%, respectively. There were no instances of recurrent aortic dissection, aortic aneurysm, or pseudoaneurysm during the entire study period. The severity of aortic regurgitation dramatically decreased immediately after surgery (from 28.6% to 0% grade 3-4 and thereafter slightly increased (from 0% to 7.2% at 5 years and 9.1% at 10 years. CONCLUSION: This modified reinforced aortic root reconstruction was feasible, safe and durable/effective, as indicated by its low mortality, low postoperative complications and high survival rate.

  1. A New Type of YumC-Like Ferredoxin (Flavodoxin) Reductase Is Involved in Ribonucleotide Reduction

    DEFF Research Database (Denmark)

    Chen, Jun; Shen, Jing; Solem, Christian

    2015-01-01

    . subtilis but that the addition of deoxynucleosides cannot compensate for the lethal phenotype displayed by the B. subtilis yumC knockout mutant. Ferredoxin (flavodoxin) reductase (FdR) is involved in many important reactions in both eukaryotes and prokaryotes, such as photosynthesis, nitrate reduction, etc. The recently...... ribonucleotide reductase, which represents the workhorse for the bioconversion of nucleotides to deoxynucleotides in many prokaryotes and eukaryotic pathogens under aerobic conditions. As the partner of the flavodoxin (NrdI), the key FdR is missing in the current model describing the class Ib system...

  2. High prevalence of cardiac involvement in patients with myotonic dystrophy type 1

    DEFF Research Database (Denmark)

    Petri, Helle; Witting, Nanna; Ersbøll, Mads Kristian

    2014-01-01

    of controls. Thus, the optimal strategy for assessing cardiac involvement in DM1 is unclear. METHOD: In this large single-centre study, we evaluated 129 unselected DM1 patients (49.6% men), mean (SD) age 44 (14.7) years with family history, physical examination, electrocardiogram (ECG), echocardiography......) arrhythmias: atrial fibrillation/flutter (4.1%), other supraventricular tachyarrhythmia (7.3%) and non-sustained ventricular tachycardia (4.1%); and 3) structural abnormalities: left ventricular systolic dysfunction (20.6%) and reduced global longitudinal strain (21.7%). A normal ECG was not significantly...

  3. Assessment of the radiological risks of road transport accidents involving type A-packages

    International Nuclear Information System (INIS)

    Lange, F.; Fett, H.J.; Schwarz, G.; Raffestin, D.; Schneider, T.; Gelder, R.; Hughes, J.S.; Shaw, K.B.; Hedberg, B.; Simenstad, P.; Svahn, B.; Van Hienen, J.F.A.; Jansma, R.

    1998-10-01

    This document, prepared in the framework of a study for the European Commission, presents the evaluation of the risks of accidents associated to the road transport of type A-packages (primarily packages of radio-pharmaceutic or radiography products) for five countries of the European Union. The annual transport of type A-packages varies considerably from one country to another, some countries being producers of radio-pharmaceutic products, others not. These packages are also very different one from each another: the weight varies generally from 1 to 25 kg and the activity from some Mega-Becquerels to few tens of Giga-Becquerels, the average activity expressed in A 2 is 0,01. (A.L.B.)

  4. INNOVATIVE TECHNIQUES USED BY EPA, SCDHEC, AND DOE TO INCREASE STAKEHOLDER AND PUBLIC INVOLVEMENT IN THE CLEANUP OF NUCLEAR PRODUCTION FACILITIES

    International Nuclear Information System (INIS)

    Mccollum, L

    2007-01-01

    This paper will describe the importance of public and stakeholder involvement to the decisions being made at Savannah River Site (SRS) regarding the cleanup of major production facilities. For over a decade the Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC) have operated under a three party agreement (known as the Federal Facilities Agreement or FFA) to clean up the SRS from the remnants of the Cold War plutonium production at SRS. During this time, the 3 agencies have consulted with the surrounding and impacted public to gain stakeholder input on the decisions concerning the clean up of various wastes at the SRS. The primary instrument of public input has been and remains the SRS Community Advisory Board (CAB). Much progress has been made over the years in cleaning up the SRS and the CAB has provided invaluable stakeholder input. Many planned decisions have been modified and changed as a result of the input of the CAB. Recently, DOE has decided to move forward with the Decommissioning of excess facilities at the SRS. These facilities include many buildings involved in the various missions of radioactive isotope production at the SRS, including the reactors and the plutonium processing facilities. The discussions of the 3 agencies on how to best accomplish this work have always included discussions about how to best involve and receive input from all stakeholders. The innovative way the 3 agencies have worked together through the public involvement format has application nationally and DOE-Complex wide. The decisions made will impact the surrounding community and the country for years. Multiple meetings with the CAB and other stakeholders will be required and it will be incumbent on the 3 agencies to reach out to and involve all interested parties. At least 3 different approaches could be used for stakeholder involvement. (1) a typical CERCLA ''proposed plan

  5. Cell-type independent MYC target genes reveal a primordial signature involved in biomass accumulation.

    Directory of Open Access Journals (Sweden)

    Hongkai Ji

    Full Text Available The functions of key oncogenic transcription factors independent of context have not been fully delineated despite our richer understanding of the genetic alterations in human cancers. The MYC oncogene, which produces the Myc transcription factor, is frequently altered in human cancer and is a major regulatory hub for many cancers. In this regard, we sought to unravel the primordial signature of Myc function by using high-throughput genomic approaches to identify the cell-type independent core Myc target gene signature. Using a model of human B lymphoma cells bearing inducible MYC, we identified a stringent set of direct Myc target genes via chromatin immunoprecipitation (ChIP, global nuclear run-on assay, and changes in mRNA levels. We also identified direct Myc targets in human embryonic stem cells (ESCs. We further document that a Myc core signature (MCS set of target genes is shared in mouse and human ESCs as well as in four other human cancer cell types. Remarkably, the expression of the MCS correlates with MYC expression in a cell-type independent manner across 8,129 microarray samples, which include 312 cell and tissue types. Furthermore, the expression of the MCS is elevated in vivo in Eμ-Myc transgenic murine lymphoma cells as compared with premalignant or normal B lymphocytes. Expression of the MCS in human B cell lymphomas, acute leukemia, lung cancers or Ewing sarcomas has the highest correlation with MYC expression. Annotation of this gene signature reveals Myc's primordial function in RNA processing, ribosome biogenesis and biomass accumulation as its key roles in cancer and stem cells.

  6. Advanced nutrient root feeding system for conveyer-type cylindrical plant growth facilities developed for microgravity

    Science.gov (United States)

    Berkovich, Yuliy A.; Smolyanina, Svetlana O.; Krivobok, Anna; Krivobok, Nikolay

    A new brand of cylindrical conveyer-type space plant growth facilities (PGF) has been created to improve of cosmonauts’ diet in the microgravity conditions. Up to date several ground prototypes of the space PGF have been made and tested: “Phytocycle”, “Vitacycle”, “Phytocycle-LED”, “Phytoconveyer”; now the space PGF “Vitacycle-T” for the Russian segment of the ISS is under developing. In the PGFs the ion-exchange salt-saturated fibrous artificial soil (AS) is used as a root medium. We have proposed the system for enrichment of irrigation water by nutrients to decrease of the AS store required for PGF working during the long space mission. The system includes root modules filled in fibrous ion-exchange AS, the enrichment column with crumble salt-saturation ion-exchange resin and the cassette with slow releasing fertilizer (SRF). Both substrates (ion-exchange resin and SRF) are necessary because of the SRF contains mostly N, P and K but another three essential elements S, Ca, Mg are provided by the ion-exchange resin. In the system water goes throw the enrichment column with ion-exchange resin fertilizing by the nutrients and comes into the mixer cell fertilize equipped with the electrical conductivity sensor. When the signal of the conductivity sensor is coming to the controller it turns on the pump directed the water flow throw the cassette with SRF until the electric conductivity of the solution in the mixer cell will reach the setpoint. The nutrient root feeding system was tested during 88 days when Chinese cabbage grew in PGF “Phytocycle-LED”. The crop has been continuously illuminated by red and blue LEDs in the PPF ratio 7 to 1; an integral PPF level has been (240 ± 10) µmol/(m2×s). There was no renewal of the used fibrous AS during the experiment. The PGF total electric power consumption was of 0,45 kW. The average fresh biomass productivity of the PGF during steady state working mode was equal 135×g/day per m2 of the illuminated

  7. An Extensive Stanford Type A Aortic Dissection Involving Bilateral Carotid and Iliac Arteries

    Directory of Open Access Journals (Sweden)

    E. W. Lee

    2013-01-01

    Full Text Available We present a rare case of continuous, extensive aortic dissection (AD involving the bilateral common carotid arteries, the ascending, thoracic, and abdominal aorta, and bifurcation of the right common iliac artery. A 61-year-old man with history of chronic hypertension presented with a one-day history of chest pain, vertigo, left facial drooping, and left hemiparesis. Despite the presence of bilateral carotid bruits, doppler ultrasound of the neck was postponed, and the patient was treated with thrombolytic therapy for a presumed ischemic stroke. The patient's symptoms began to resolve within an hour of treatment, at which time treatment was withheld. Ultrasound performed the following day showed dissection of bilateral common carotid arteries, and CT angiography demonstrated extensive AD as described earlier. The patient subsequently underwent cardiovascular surgery and has been doing clinically well since then. AD has a myriad of manifestations depending on the involvement of aortic branches. Our paper illustrates the importance of having a high index of suspicion for AD when a patient presents with a picture of ischemic stroke, since overlapping signs and symptoms exist between AD and stroke. Differentiating between the two conditions is central to patient care as thrombolytic therapy can be helpful in stroke, but detrimental in AD.

  8. [Disseminated cutaneous sporotrichosis with joint involvement in a woman with type 2 diabetes].

    Science.gov (United States)

    Solorzano, Sendy; Ramirez, Renán; Cabada, Miguel M; Montoya, Manuel; Cazorla, Ernesto

    2015-01-01

    Disseminated sporotrichosis is a rare presentation of this mycosis. Although it has been described in immunocompetent individuals, there is often T cell-mediated immune compromise. We report the case of a woman with uncontrolled Type 2 diabetes who developed disseminated cutaneous sporotrichosis. The course of the disease presented several complications including hepatitis secondary to itraconazole and knee arthritis with culture positive for Sporothrix schenckii during treatment with saturated solution of potassium iodide. The case discussion includes aspects of the pathogenesis of disseminated sporotrichosis and management of the infection and its complications.

  9. Experimental facility of innovative types as the laboratory analog of research reactor experimental device

    International Nuclear Information System (INIS)

    Androsenko, A.A.; Androsenko, P.A.; Zabud'ko, A.N.; Kremenetskij, A.K.; Nikolaev, A.N.; Trykov, L.A.

    1991-01-01

    The paper analyses capability of creating laboratory analogs of complex experimental facilities at research reactors utilizing power radionuclide neutron sources fabricated in industrial conditions. Some experimental and calculational investigations of neutron-physical characteristics are presented, which have been attained at the RIZ research reactor laboratory analog. Experimental results are supplemented by calculational investigations, fulfilled by means of the BRAND three-dimensional computational complex and the ROZ-6 one-dimensional program. 4 refs.; 3 figs

  10. A single type of cadherin is involved in Bacillus thuringiensis toxicity in Plutella xylostella.

    Science.gov (United States)

    Park, Y; Herrero, S; Kim, Y

    2015-12-01

    Cadherins have been described as one the main functional receptors for the toxins of the entomopathogenic bacterium, Bacillus thuringiensis (Bt). With the availability of the whole genome of Plutella xylostella, different types of cadherins have been annotated. In this study we focused on determining those members of the cadherin-related proteins that potentially play a role in the mode of action of Bt toxins. For this, we mined the genome of P. xylostella to identify these putative cadherins. The genome screening revealed 52 genes that were annotated as cadherin or cadherin-like genes. Further analysis revealed that six of these putative cadherins had three motifs common to all Bt-related cadherins: a signal peptide, cadherin repeats and a transmembrane domain. From the six selected cadherins, only P. xylostella cadherin 1 (PxCad1) was expressed in the larval midgut and only the silencing of this gene by RNA interference (double-stranded RNA feeding) reduce toxicity and binding to the midgut of the Cry1Ac type toxin from Bt. These results indicate that from the whole set of cadherin-related genes identified in P. xylostella, only PxCad1 is associated with the Cry1Ac mode of action. © 2015 The Royal Entomological Society.

  11. Digenic mutations involving both the BSND and GJB2 genes detected in Bartter syndrome type IV.

    Science.gov (United States)

    Wang, Hong-Han; Feng, Yong; Li, Hai-Bo; Wu, Hong; Mei, Ling-Yun; Wang, Xing-Wei; Jiang, Lu; He, Chu-Feng

    2017-01-01

    Bartter syndrome type IV, characterized by salt-losing nephropathies and sensorineural deafness, is caused by mutations of BSND or simultaneous mutations of both CLCNKA and CLCNKB. GJB2 is the primary causative gene for non-syndromic sensorineural deafness and associated with several syndromic sensorineural deafness. Owing to the rarity of Bartter syndrome, only a few mutations have been reported in the abovementioned causative genes. To investigate the underlying mutations in a Chinese patient with Bartter syndrome type IV, genetic analysis of BSND, CLCNKA, CLCNKB and GJB2 were performed by polymerase chain reaction and direct sequencing. Finally, double homozygous mutations c.22C > T (p.Arg8Trp) and c.127G > A (Val43Ile) were detected in exon 1 of BSND. Intriguingly, compound heterozygous mutations c.235delC (p.Leu79CysfsX3) and c.109G > A (p.Val37Ile) were also revealed in exon 2 of GJB2 in the same patient. No pathogenic mutations were found in CLCNKA and CLCNKB. Our results indicated that the homozygous mutation c.22C > T was the key genetic reason for the proband, and a digenic effect of BSND and GJB2 might contributed to sensorineural deafness. To our knowledge, it was the first report showing that the GJB2 gene mutations were detected in Bartter syndrome. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  12. Outbreak of OXA-48-Producing Klebsiella pneumoniae Involving a Sequence Type 101 Clone in Batna University Hospital, Algeria.

    Science.gov (United States)

    Loucif, Lotfi; Kassah-Laouar, Ahmed; Saidi, Mahdia; Messala, Amina; Chelaghma, Widad; Rolain, Jean-Marc

    2016-12-01

    Seven nonredundant ertapenem-resistant Klebsiella pneumoniae isolates were collected between May 2014 and 19 January 2015 in the nephrology and hematology units of Batna University Hospital in Algeria. All strains coproduced the bla OXA-48 , bla CTX-M-15 , bla SHV-1 , and bla TEM-1D genes. Six of these isolates belonged to the pandemic clone sequence type 101 (ST101). The bla OXA-48 gene was located on a conjugative IncL/M-type plasmid. This is the first known outbreak of OXA-48-producing K. pneumoniae isolates involving an ST101 clone in Batna University Hospital. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  13. Effects of information type on children's interrogative suggestibility: is Theory-of-Mind involved?

    Science.gov (United States)

    Hünefeldt, Thomas; Rossi-Arnaud, Clelia; Furia, Augusta

    2009-08-01

    This research was aimed at learning more about the different psychological mechanisms underlying children's suggestibility to leading questions, on the one hand, and children's suggestibility to negative feedback, on the other, by distinguishing between interview questions concerning different types of information. Results showed that, unlike the developmental pattern of children's suggestibility to leading questions, the developmental pattern of children's suggestibility to negative feedback differed depending on whether the interview questions concerned external facts (physical states and events) or internal facts (mental states and events). This difference was not manifested in response to questions concerning central versus peripheral facts. Results are interpreted in terms of the hypothesis that children's suggestibility to negative feedback is differently affected by "Theory-of-Mind" abilities than children's suggestibility to leading questions. Further research is needed in order to test this hypothesis.

  14. A Liouville type theorem for Lane-Emden systems involving the fractional Laplacian

    Science.gov (United States)

    Quaas, Alexander; Xia, Aliang

    2016-08-01

    We establish a Liouville type theorem for the fractional Lane-Emden system: {(-Δ)αu=vqin  RN,(-Δ)αv=upin  RN, where α \\in (0,1) , N>2α and p, q are positive real numbers and in an appropriate new range. To prove our result we will use the local realization of fractional Laplacian, which can be constructed as a Dirichlet-to-Neumann operator of a degenerate elliptic equation in the spirit of Caffarelli and Silvestre (2007 Commun. PDE 32 1245-60). Our proof is based on a monotonicity argument for suitable transformed functions and the method of moving planes in a half infinite cylinder ({IR}× S+N , where S+N is the half unit sphere in {{{R}}N+1} ) based on maximum principles which are obtained by barrier functions and a coupling argument using a fractional Sobolev trace inequality.

  15. Synchronization of chaotic systems involving fractional operators of Liouville-Caputo type with variable-order

    Science.gov (United States)

    Coronel-Escamilla, A.; Gómez-Aguilar, J. F.; Torres, L.; Escobar-Jiménez, R. F.; Valtierra-Rodríguez, M.

    2017-12-01

    In this paper, we propose a state-observer-based approach to synchronize variable-order fractional (VOF) chaotic systems. In particular, this work is focused on complete synchronization with a so-called unidirectional master-slave topology. The master is described by a dynamical system in state-space representation whereas the slave is described by a state observer. The slave is composed of a master copy and a correction term which in turn is constituted of an estimation error and an appropriate gain that assures the synchronization. The differential equations of the VOF chaotic system are described by the Liouville-Caputo and Atangana-Baleanu-Caputo derivatives. Numerical simulations involving the synchronization of Rössler oscillators, Chua's systems and multi-scrolls are studied. The simulations show that different chaotic behaviors can be obtained if different smooths functions defined in the interval (0 , 1 ] are used as the variable order of the fractional derivatives. Furthermore, simulations show that the VOF chaotic systems can be synchronized.

  16. Intact long-type DupA protein in Helicobacter pylori is an ATPase involved in multifunctional biological activities.

    Science.gov (United States)

    Wang, Ming-yi; Chen, Cheng; Shao, Chen; Wang, Shao-bo; Wang, Ai-chu; Yang, Ya-chao; Yuan, Xiao-yan; Shao, Shi-he

    2015-04-01

    The function of intact long-type DupA protein in Helicobacter pylori was analyzed using immunoblotting and molecular biology techniques in the study. After cloning, expression and purification, ATPase activity of DupA protein was detected. Antibody was produced for localization and interaction proteins analysis. The dupA-deleted mutant was generated for adhesion and CagA protein translocation assay, susceptibility to different pH, IL-8 secretion assay, cytotoxicity to MKN-45 cells and proteins-involved apoptosis analysis. DupA protein exhibited an ATPase activity (129.5±17.8 U/mgprot) and located in bacterial membrane, while it did not involve the adhesion and CagA protein delivery of H. pylori. DupA protein involved the urease secretion as the interaction proteins. The wild type strain had a stronger growth in low pH than the dupA-deleted mutant (p DupA protein located in membrane as ATPase is a true virulence factor associated with duodenal ulcer development involving the IL-8 induction and urease secretion, while it inhibits gastric cancer cell growth in vitro by activating the mitochondria-mediated apoptotic pathway. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Medication errors: classification of seriousness, type, and of medications involved in the reports from a university teaching hospital

    Directory of Open Access Journals (Sweden)

    Gabriella Rejane dos Santos Dalmolin

    2013-12-01

    Full Text Available Medication errors can be frequent in hospitals; these errors are multidisciplinary and occur at various stages of the drug therapy. The present study evaluated the seriousness, the type and the drugs involved in medication errors reported at the Hospital de Clínicas de Porto Alegre. We analyzed written error reports for 2010-2011. The sample consisted of 165 reports. The errors identified were classified according to seriousness, type and pharmacological class. 114 reports were categorized as actual errors (medication errors and 51 reports were categorized as potential errors. There were more medication error reports in 2011 compared to 2010, but there was no significant change in the seriousness of the reports. The most common type of error was prescribing error (48.25%. Errors that occurred during the process of drug therapy sometimes generated additional medication errors. In 114 reports of medication errors identified, 122 drugs were cited. The reflection on medication errors, the possibility of harm resulting from these errors, and the methods for error identification and evaluation should include a broad perspective of the aspects involved in the occurrence of errors. Patient safety depends on the process of communication involving errors, on the proper recording of information, and on the monitoring itself.

  18. The immunoglobulin superfamily member CD200R identifies cells involved in type 2 immune responses

    DEFF Research Database (Denmark)

    Blom, Lars H; Martel, Britta C; Larsen, Lau F

    2017-01-01

    of this investigation was to identify surface markers associated with type 2 inflammation. METHODS: Naïve human CD4(+) T-cells were short-term activated in the presence or absence of IL-4, and analysed for expression of >300 cell-surface proteins. Ex vivo isolated PBMCs from peanut and non-allergic allergic subjects......, were stimulated (14-16h) with peanut extract to detect peanut-specific CD4(+) CD154(+) T-cells. Biopsies were obtained for transcriptomic analysis from healthy controls and patients with extrinsic or intrinsic atopic dermatitis and psoriasis. RESULTS: Expression analysis of >300 surface proteins...... and ILC2 cells and basophils. In peanut-allergic subjects the peanut-specific Th2 (CD154(+) CRTh2(+) ) cells expressed more CD200R than the non-allergen specific Th2 (CD154(-) CRTh2(+) ) cells. Moreover, co-staining of CD161 and CD200R identified peanut-specific highly differentiated IL-4(+) IL-5(+) Th2...

  19. Relationship Between Scarring and Dog Aggression in Pit Bull-Type Dogs Involved in Organized Dogfighting

    Directory of Open Access Journals (Sweden)

    Katherine A. Miller

    2016-11-01

    Full Text Available When pit bull-type dogs are seized in an investigation of organized dogfighting, heavily scarred dogs are often assumed to be highly dog aggressive due to a history of fighting. These dogs may be deemed dangerous and euthanized based on scarring alone. We analyzed our existing data on dogs seized from four dogfighting investigations, examining the relationship between the dogs’ scars with aggression towards other dogs. Scar and wound data were tallied in three body zones where dogfighting injuries tend to be concentrated. Dog aggression was assessed using a model dog and a friendly stimulus dog in a standardized behavior evaluation. Scarring and dog aggression were significantly related, more strongly among male (Fisher’s Exact p < 0.001 than female dogs (Fisher’s Exact p = 0.05. Ten or more scars in the three body zones was a reasonable threshold with which to classify a dog as high risk for dog aggression: 82% of males and 60% of females with such scarring displayed dog aggression. However, because many unscarred dogs were dog aggressive while some highly scarred dogs were not, we recommend collecting behavioral information to supplement scar counts when making disposition decisions about dogs seized in dogfighting investigations.

  20. New aspects of vascular remodelling: the involvement of all vascular cell types.

    Science.gov (United States)

    McGrath, John C; Deighan, Clare; Briones, Ana M; Shafaroudi, Majid Malekzadeh; McBride, Melissa; Adler, Jeremy; Arribas, Silvia M; Vila, Elisabet; Daly, Craig J

    2005-07-01

    Conventionally, the architecture of arteries is based around the close-packed smooth muscle cells and extracellular matrix. However, the adventitia and endothelium are now viewed as key players in vascular growth and repair. A new dynamic picture has emerged of blood vessels in a constant state of self-maintenance. Recent work raises fundamental questions about the cellular heterogeneity of arteries and the time course and triggering of normal and pathological remodelling. A common denominator emerging in hypertensive remodelling is an early increase in adventitial cell density suggesting that adventitial cells drive remodelling and may initiate subsequent changes such as re-arrangement of smooth muscle cells and extracellular matrix. The organization of vascular smooth muscle cells follows regular arrangements that can be modelled mathematically. In hypertension, new patterns can be quantified in these terms and give insights to how structure affects function. As with smooth muscle, little is known about the organization of the vascular endothelium, or its role in vascular remodelling. Current observations suggest that there may be a close relationship between the helical organization of smooth muscle cells and the underlying pattern of endothelial cells. The function of myoendothelial connections is a topic of great current interest and may relate to the structure of the internal elastic lamina through which the connections must pass. In hypertensive remodelling this must present an organizational challenge. The objective of this paper is to show how the functions of blood vessels depend on their architecture and a continuous interaction of different cell types and extracellular proteins.

  1. Effects of three types of physical activity on reduction of metabolic parameters involved in cardiovascular risk

    Directory of Open Access Journals (Sweden)

    Petrović-Oggiano Gordana

    2009-01-01

    Full Text Available The aim of present study was to investigate the effects of three different types of physical activity on reduction of the metabolic parameters mainly responsible for cardiovascular diseases. This prospective-intervention study was performed at the 'ČIGOTA' Thyroid Institute on Mt. Zlatibor (Serbia between August 2004 and June 2006. Sixty-eight overweight/obese patients aged 40-70 years with hyperlipidemia were divided into three groups according to their weight and overall health. The program of physical workout included: group I - fast walking; group II - gymnastic exercises and specially chosen exercises in the swimming pool; and group III - combined physical training of higher intensity and greater length. All patients were also on a special reduced diet of 1000 kcal per day, the AHA step-2 diet. We monitored the body mass index, body composition, glucose, cholesterol (total, LDL-, and HDL-, and triglycerides before, during, and after the intervention. After 2 and particularly 12 weeks of intervention, a significant improvement of all metabolic parameters was achieved in all three groups of patients. Although most patients completed the study with normal values of all parameters, the most desirable results were achieved in group III (combined exercises with an average energy expenditure of 900 kcal per day. Our research indicates that a specially conceived program of physical activity and diet intervention resulted in significant reduction of cardiovascular risk factors.

  2. E-SCAPE: A scale facility for liquid-metal, pool-type reactor thermal hydraulic investigations

    Energy Technology Data Exchange (ETDEWEB)

    Van Tichelen, Katrien, E-mail: kvtichel@sckcen.be [SCK-CEN, Boeretang 200, 2400 Mol (Belgium); Mirelli, Fabio, E-mail: fmirelli@sckcen.be [SCK-CEN, Boeretang 200, 2400 Mol (Belgium); Greco, Matteo, E-mail: mgreco@sckcen.be [SCK-CEN, Boeretang 200, 2400 Mol (Belgium); Viviani, Giorgia, E-mail: giorgiaviviani@gmail.com [University of Pisa, Lungarno Pacinotti 43, 56126 Pisa (Italy)

    2015-08-15

    Highlights: • The E-SCAPE facility is a thermal hydraulic scale model of the MYRRHA fast reactor. • The focus is on mixing and stratification in liquid-metal pool-type reactors. • Forced convection, natural convection and the transition are investigated. • Extensive instrumentation allows validation of computational models. • System thermal hydraulic and CFD models have been used for facility design. - Abstract: MYRRHA (Multi-purpose hYbrid Research Reactor for High-tech Applications) is a flexible fast-spectrum research reactor under design at SCK·CEN. MYRRHA is a pool-type reactor with lead bismuth eutectic (LBE) as primary coolant. The proper understanding of the thermal hydraulic phenomena occurring in the reactor pool is an important issue in the design and licensing of the MYRRHA system and liquid-metal cooled reactors by extension. Model experiments are necessary for understanding the physics, for validating experimental tools and to qualify the design for the licensing. The E-SCAPE (European SCAled Pool Experiment) facility at SCK·CEN is a thermal hydraulic 1/6-scale model of the MYRRHA reactor, with an electrical core simulator, cooled by LBE. It provides experimental feedback to the designers on the forced and natural circulation flow patterns. Moreover, it enables to validate the computational methods for their use with LBE. The paper will elaborate on the design of the E-SCAPE facility and its main parameters. Also the experimental matrix and the pre-test analysis using computational fluid dynamics (CFD) and system thermal hydraulics codes will be described.

  3. Safety assessment of a borehole type disposal facility using the ISAM methodology

    International Nuclear Information System (INIS)

    Blerk, J.J. van; Yucel, V.; Kozak, M.W.; Moore, B.A.

    2002-01-01

    As part of the IAEA's Co-ordinated Research Project (CRP) on Improving Long-term of Safety Assessment Methodologies for Near Surface Waste Disposal Facilities (ISAM), three example cases were developed. The aim was to test the ISAM safety assessment methodology using as realistic as possible data. One of the Test Cases, the Borehole Test Case (BTC), related to a proposed future disposal option for disused sealed radioactive sources. This paper uses the various steps of the ISAM safety assessment methodology to describe the work undertaken by ISAM participants in developing the BTC and provides some general conclusions that can be drawn from the findings of their work. (author)

  4. Aneuploidy involving chromosome 1 may be an early predictive marker of intestinal type gastric cancer

    Energy Technology Data Exchange (ETDEWEB)

    Williams, L. [Royal Glamorgan Hospital, Ynysmaerdy, Llantrisant CF72 8XR (United Kingdom); Somasekar, A. [Institute of Life Science, Swansea School of Medicine, Swansea University, Swansea SA28PP (United Kingdom); Neath Port Talbot Hospital, Abertawe Bro Morgannwg University NHS Trust, Baglan Way, Port Talbot SA12 7BX (United Kingdom); Davies, D.J.; Cronin, J.; Doak, S.H. [Institute of Life Science, Swansea School of Medicine, Swansea University, Swansea SA28PP (United Kingdom); Alcolado, R. [Royal Glamorgan Hospital, Ynysmaerdy, Llantrisant CF72 8XR (United Kingdom); Williams, J.G. [Neath Port Talbot Hospital, Abertawe Bro Morgannwg University NHS Trust, Baglan Way, Port Talbot SA12 7BX (United Kingdom); Griffiths, A.P. [Department of Histopathology, Morriston Hospital, Abertawe Bro Morgannwg University NHS Trust, Morriston, SA66NL (United Kingdom); Baxter, J.N. [Department of Surgery, Morriston Hospital, Abertawe Bro Morgannwg University NHS Trust, Morriston, SA66NL (United Kingdom); Jenkins, G.J.S., E-mail: g.j.jenkins@swansea.ac.uk [Institute of Life Science, Swansea School of Medicine, Swansea University, Swansea SA28PP (United Kingdom)

    2009-10-02

    Intestinal type gastric cancer is a significant cause of mortality, therefore a better understanding of its molecular basis is required. We assessed if either aneuploidy or activity of the oncogenic transcription factor nuclear factor kappa B (NF-{kappa}B), increased incrementally during pre-malignant gastric histological progression and also if they correlated with each other in patient samples, as they are both induced by oxygen free radicals. In a prospective study of 54 (aneuploidy) and 59 (NF-{kappa}B) consecutive patients, aneuploidy was assessed by interphase fluorescent in situ hybridisation (FISH) for chromosome 1. NF-{kappa}B was assessed by expression of interleukin-8 (IL-8), and in a subset, by immunohistochemistry (IHC) for active p65. Aneuploidy levels increased incrementally across the histological series. 2.76% of cells with normal histology (95% CI, 2.14-3.38%) showed background levels of aneuploidy, this increased to averages of 3.78% (95% CI, 3.21-4.35%), 5.89% (95% CI, 3.72-8.06%) and 7.29% (95% CI, 4.73-9.85%) of cells from patients with gastritis, Helicobacter pylori positive gastritis and atrophy/intestinal metaplasia (IM) respectively. IL-8 expression was only increased in patients with current H. pylori infection. NF-{kappa}B analysis showed some increased p65 activity in inflamed tissues. IL-8 expression and aneuploidy level were not linked in individual patients. Aneuploidy levels increased incrementally during histological progression; were significantly elevated at very early stages of neoplastic progression and could well be linked to cancer development and used to assess cancer risk. Reactive oxygen species (ROS) induced in early gastric cancer are presumably responsible for the stepwise accumulation of this particular mutation, i.e. aneuploidy. Hence, aneuploidy measured by fluorescent in situ hybridisation (FISH) coupled to brush cytology, would be worthy of consideration as a predictive marker in gastric cancer and could be

  5. Aneuploidy involving chromosome 1 may be an early predictive marker of intestinal type gastric cancer

    International Nuclear Information System (INIS)

    Williams, L.; Somasekar, A.; Davies, D.J.; Cronin, J.; Doak, S.H.; Alcolado, R.; Williams, J.G.; Griffiths, A.P.; Baxter, J.N.; Jenkins, G.J.S.

    2009-01-01

    Intestinal type gastric cancer is a significant cause of mortality, therefore a better understanding of its molecular basis is required. We assessed if either aneuploidy or activity of the oncogenic transcription factor nuclear factor kappa B (NF-κB), increased incrementally during pre-malignant gastric histological progression and also if they correlated with each other in patient samples, as they are both induced by oxygen free radicals. In a prospective study of 54 (aneuploidy) and 59 (NF-κB) consecutive patients, aneuploidy was assessed by interphase fluorescent in situ hybridisation (FISH) for chromosome 1. NF-κB was assessed by expression of interleukin-8 (IL-8), and in a subset, by immunohistochemistry (IHC) for active p65. Aneuploidy levels increased incrementally across the histological series. 2.76% of cells with normal histology (95% CI, 2.14-3.38%) showed background levels of aneuploidy, this increased to averages of 3.78% (95% CI, 3.21-4.35%), 5.89% (95% CI, 3.72-8.06%) and 7.29% (95% CI, 4.73-9.85%) of cells from patients with gastritis, Helicobacter pylori positive gastritis and atrophy/intestinal metaplasia (IM) respectively. IL-8 expression was only increased in patients with current H. pylori infection. NF-κB analysis showed some increased p65 activity in inflamed tissues. IL-8 expression and aneuploidy level were not linked in individual patients. Aneuploidy levels increased incrementally during histological progression; were significantly elevated at very early stages of neoplastic progression and could well be linked to cancer development and used to assess cancer risk. Reactive oxygen species (ROS) induced in early gastric cancer are presumably responsible for the stepwise accumulation of this particular mutation, i.e. aneuploidy. Hence, aneuploidy measured by fluorescent in situ hybridisation (FISH) coupled to brush cytology, would be worthy of consideration as a predictive marker in gastric cancer and could be clinically useful in pre

  6. Relationship Between Scarring and Dog Aggression in Pit Bull-Type Dogs Involved in Organized Dogfighting

    Science.gov (United States)

    Miller, Katherine A.; Touroo, Rachel; Spain, C. Victor; Jones, Kelly; Reid, Pamela; Lockwood, Randall

    2016-01-01

    Simple Summary Organizations responsible for placing dogs seized from dogfighting investigations often must determine if a particular dog should be euthanized because it is too dangerous or if it is safe to place the dog in an adoptive home. In this study, we examine whether the extent of scarring from dog fighting is a reliable predictor of aggression towards other dogs and therefore could be used to help make that decision. We found that dogs with 10 or more scars in the three body zones where dogfighting injuries tend to be concentrated were more likely, on average, to show aggression to other dogs. The relationship is imperfect, however. Many unscarred dogs were dog aggressive while some highly scarred dogs were not. Therefore, we recommend also assessing a dog’s behavior before making decisions about its disposition. Abstract When pit bull-type dogs are seized in an investigation of organized dogfighting, heavily scarred dogs are often assumed to be highly dog aggressive due to a history of fighting. These dogs may be deemed dangerous and euthanized based on scarring alone. We analyzed our existing data on dogs seized from four dogfighting investigations, examining the relationship between the dogs’ scars with aggression towards other dogs. Scar and wound data were tallied in three body zones where dogfighting injuries tend to be concentrated. Dog aggression was assessed using a model dog and a friendly stimulus dog in a standardized behavior evaluation. Scarring and dog aggression were significantly related, more strongly among male (Fisher’s Exact p < 0.001) than female dogs (Fisher’s Exact p = 0.05). Ten or more scars in the three body zones was a reasonable threshold with which to classify a dog as high risk for dog aggression: 82% of males and 60% of females with such scarring displayed dog aggression. However, because many unscarred dogs were dog aggressive while some highly scarred dogs were not, we recommend collecting behavioral information to

  7. Association between the time perspective and type of involvement in bullying among adolescents: A cross-sectional study in Japan.

    Science.gov (United States)

    Mizuta, Akiko; Okada, Eisaku; Nakamura, Mieko; Yamaguchi, Hisayoshi; Ojima, Toshiyuki

    2018-04-01

    To examine the association between the types of involvement in bullying and the time perspective among Japanese adolescents. A questionnaire was conducted among Japanese junior high school students at eight public schools that were located in two cities in Shizuoka Prefecture, Japan. Shirai's Experiential Time Perspective Scale was used, which comprises four subscales: goal-directedness, hopefulness, self-fulfillment, and acceptance of the past. An analysis of covariance was applied, with the time-perspective subscales as the objective variable, type of involvement in bullying as a fixed factor, and grade, family structure, and economic status as the covariates. The analysis sample included 2630 adolescents (valid response rate: 88.6%). The bullying rate of the boys was 10.8% and 4.1% for the girls, for the male victims it was 10.1% and 14.5% for the female victims, and for both the bully and the victim, it was 8.5% and 5.4%, respectively. The students who were not involved in bullying had the highest scores of hopefulness, self-fulfillment, and acceptance of the past. For both sexes, bullying was significantly associated with hopefulness, self-fulfillment, and acceptance of the past. Goal-directedness was not associated with the type of involvement in bullying. The victims of bullying had low time perspectives of hopefulness, self-fulfillment, and acceptance of the past. Providing support that increases hopefulness, self-fulfillment, and acceptance of the past might help to prevent pessimistic decision-making, such as that seen in cases of suicide. © 2017 Japan Academy of Nursing Science.

  8. Development of one body α-γ type manipulator for hot cell facility

    International Nuclear Information System (INIS)

    Jung, S. K.; Lee, S. B.; Lee, E. P.

    2004-01-01

    To handle the high level radioactive materials in a sealed type hot cell, our company has developed the one body alpha-gamma type manipulator and this is an improved model compared with the previously developed beta-gamma and separated alpha-gamma type manipulators. The successful development of one body alpha-gamma type manipulator means our company has a whole capacity to design and fabricate all kinds of manipulators using in hot cells. Until now most of the manipulators in Korea were imported from other countries. The development of Korean manipulators gives us the easier maintenance and lower price compared to the foreign products. It is also possible to export the Korean manipulators to overseas

  9. Tests of the space gamma spectrometer prototype at the JINR experimental facility with different types of neutron generators

    Science.gov (United States)

    Litvak, M. L.; Vostrukhin, A. A.; Golovin, D. V.; Dubasov, P. V.; Zontikov, A. O.; Kozyrev, A. S.; Krylov, A. R.; Krylov, V. A.; Mitrofanov, I. G.; Mokrousov, M. I.; Repkin, A. N.; Timoshenko, G. N.; Udovichenko, K. V.; Shvetsov, V. N.

    2017-07-01

    The results of the tests of the HPGe gamma spectrometer performed with a planetary soil model and different types of pulse neutron generators are presented. All measurements have been performed at the experimental nuclear planetary science facility (Joint Institute for Nuclear Research) for the physical calibration of active gamma and neutron spectrometers. The aim of the study is to model a space experiment on determining the elemental composition of Martian planetary matter by neutron-induced gamma spectroscopy. The advantages and disadvantages of a gas-filled neutron generator in comparison with a vacuum-tube neutron generator are examined.

  10. Radiation shielding at interim storage facility for CANDU-type nuclear spent fuel

    International Nuclear Information System (INIS)

    Mateescu, S.; Radu, M. Pantazi D.; Stanciu, M.

    1997-01-01

    Technical measures in radiological protection are taken in the interim storage facility design to ensure that, during normal operation, exposures of workers and members of public to ionizing radiation are limited to levels lower than regulatory limits. The spent fuel storage design provides for radiation exposure to be as low as reasonable achievable (ALARA principles). The evaluation of radiation shields includes the most conservative provisions: - all locations which may contain spent fuel are full; - the spent fuel has reached the maximum burnup; - the post irradiation cooling period should be the minimum reasonable; - equipment for handling contains the maximum amount of spent fuel. Radiation shields should ensure that external radiation fields do not exceed limits accepted by the Regulatory Body Module. The evaluation has been performed with two computer codes, QAD-5K and MICROSHIELD-4. (authors)

  11. Automatic stair-climbing algorithm of the planetary wheel type mobile robot in nuclear facilities

    International Nuclear Information System (INIS)

    Kim, Byung Soo; Kim, Seung Ho; Lee, Jong Min

    1995-01-01

    A mobile robot, named KAEROT, has been developed for inspection and maintenance operations in nuclear facilities. The main feature of locomotion system is the planetary wheel assembly with small wheels. This mechanism has been designed to be able to go over the stairs and obstacles with stability. This paper presents the inverse kinematic solution that is to be operated by remote control. The automatic stair climbing algorithm is also proposed. The proposed algorithms the moving paths of small wheels and calculates the angular velocity of 3 actuation wheels. The results of simulations and experiments are given for KAEROT performed on the irregular stairs in laboratory. It is shown that the proposed algorithm provides the lower inclination angle of the robot body and increases its stability during navigation. 14 figs., 16 refs. (Author)

  12. Automatic stair-climbing algorithm of the planetary wheel type mobile robot in nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Byung Soo; Kim, Seung Ho; Lee, Jong Min [Korea Atomic Energy Research Institute, Taejon (Korea, Republic of)

    1995-10-01

    A mobile robot, named KAEROT, has been developed for inspection and maintenance operations in nuclear facilities. The main feature of locomotion system is the planetary wheel assembly with small wheels. This mechanism has been designed to be able to go over the stairs and obstacles with stability. This paper presents the inverse kinematic solution that is to be operated by remote control. The automatic stair climbing algorithm is also proposed. The proposed algorithms the moving paths of small wheels and calculates the angular velocity of 3 actuation wheels. The results of simulations and experiments are given for KAEROT performed on the irregular stairs in laboratory. It is shown that the proposed algorithm provides the lower inclination angle of the robot body and increases its stability during navigation. 14 figs., 16 refs. (Author).

  13. Commissioning dosimetry for the laboratory irradiation facility type PX-γ-30

    International Nuclear Information System (INIS)

    Prieto Miranda, E.F.; Cuesta Fuente, G.I.; Chavez Ardanza, A.; Sainz Vidal, D.

    1997-01-01

    In the present paper at the laboratory irradiation type PX-y-30 was carried out the commissioning dosimetry, which belongs to Radiological Department of the CEADEN. It was determined the dose distribution as well as principal dosimetric parameters of the irradiation process. Besides, an irradiation position was found for the calibration or intercomparison of dosimetry systems

  14. Involvement of viral envelope GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin

    International Nuclear Information System (INIS)

    Usami, Katsuaki; Matsuno, Keita; Igarashi, Manabu; Denda-Nagai, Kaori; Takada, Ayato; Irimura, Tatsuro

    2011-01-01

    Highlights: → Ebola virus infection is mediated by binding to and fusion with the target cells. → Structural feature of the viral glycoprotein determines the infectivity. → Surface C-type lectin, MGL, of macrophages and dendritic cells mediate the infection. → GP2, one of glycoprotein subunits, plays an essential role in MGL-mediated infection. → There is a critical amino acid residue involved in high infectivity. -- Abstract: Ebola virus (EBOV) infection is initiated by the interaction of the viral surface envelope glycoprotein (GP) with the binding sites on target cells. Differences in the mortality among different species of the Ebola viruses, i.e., Zaire ebolavirus (ZEBOV) and Reston ebolavirus (REBOV), correspond to the in vitro infectivity of the pseudo-typed virus constructed with the GPs in cells expressing macrophage galactose-type calcium-type lectin (MGL/CD301). Through mutagenesis of GP2, the transmembrane-anchored subunit of GP, we found that residues 502-527 of the GP2 sequence determined the different infectivity between VSV-ZEBOV GP and -REBOV GP in MGL/CD301-expressing cells and a histidine residue at position 516 of ZEBOV GP2 appeared essential in the differential infectivity. These findings may provide a clue to clarify a molecular basis of different pathogenicity among EBOV species.

  15. Involvement of viral envelope GP2 in Ebola virus entry into cells expressing the macrophage galactose-type C-type lectin

    Energy Technology Data Exchange (ETDEWEB)

    Usami, Katsuaki [Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033 (Japan); Matsuno, Keita; Igarashi, Manabu [Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001-0020 (Japan); Denda-Nagai, Kaori [Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033 (Japan); Takada, Ayato [Department of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo 001-0020 (Japan); Irimura, Tatsuro, E-mail: irimura@mol.f.u-tokyo.ac.jp [Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033 (Japan)

    2011-04-01

    Highlights: {yields} Ebola virus infection is mediated by binding to and fusion with the target cells. {yields} Structural feature of the viral glycoprotein determines the infectivity. {yields} Surface C-type lectin, MGL, of macrophages and dendritic cells mediate the infection. {yields} GP2, one of glycoprotein subunits, plays an essential role in MGL-mediated infection. {yields} There is a critical amino acid residue involved in high infectivity. -- Abstract: Ebola virus (EBOV) infection is initiated by the interaction of the viral surface envelope glycoprotein (GP) with the binding sites on target cells. Differences in the mortality among different species of the Ebola viruses, i.e., Zaire ebolavirus (ZEBOV) and Reston ebolavirus (REBOV), correspond to the in vitro infectivity of the pseudo-typed virus constructed with the GPs in cells expressing macrophage galactose-type calcium-type lectin (MGL/CD301). Through mutagenesis of GP2, the transmembrane-anchored subunit of GP, we found that residues 502-527 of the GP2 sequence determined the different infectivity between VSV-ZEBOV GP and -REBOV GP in MGL/CD301-expressing cells and a histidine residue at position 516 of ZEBOV GP2 appeared essential in the differential infectivity. These findings may provide a clue to clarify a molecular basis of different pathogenicity among EBOV species.

  16. Feasibility Study of SSTO Base Heating Simulation in Pulsed-Type Facilities

    Science.gov (United States)

    Park, Chung Sik; Sharma, Surendra; Edwards, Thomas A. (Technical Monitor)

    1995-01-01

    A laboratory simulation of the base heating environment of the proposed reusable Single-Stage-To-Orbit vehicle during its ascent flight was proposed. The rocket engine produces CO2 and H2, which are the main combustible components of the exhaust effluent. The burning of these species, known as afterburning, enhances the base region gas temperature as well as the base heating. To determine the heat flux on the SSTO vehicle, current simulation focuses on the thermochemistry of the afterburning, thermophysical properties of the base region gas, and ensuing radiation from the gas. By extrapolating from the Saturn flight data, the Damkohler number for the afterburning of SSTO vehicle is estimated to be of the order of 10. The limitations on the material strengths limit the laboratory simulation of the flight Damkohler number as well as other flow parameters. A plan is presented in impulse facilities using miniature rocket engines which generate the simulated rocket plume by electric ally-heating a H2/CO2 mixture.

  17. Facile synthesis of cyclopentenone B1- and L1-type Phytoprostanes

    Directory of Open Access Journals (Sweden)

    Alexandre eGuy

    2015-07-01

    Full Text Available Phytoprostanes (PhytoPs represent non-enzymatic metabolites of α-linolenic acid (ALA, the essential omega-3 polyunsaturated fatty acid (PUFA derived from plants. PhytoPs are present in the plant kingdom and represent endogenous mediators capable of protecting cells from oxidative stress damages in plants. Recently, it was found that such metabolites are present in cooking oil in high quantities, and also that B1-PhytoPs protect immature neurons from oxidant injury and promote differentiation of oligodendrocyte progenitors through PPAR-γ activation. We report a novel and facile synthesis of natural 2,3-substituted cyclopentenone PhytoPs, 16-B1-PhytoP and 9-L1-PhytoP. Our strategy is based on reductive alkylation at the 2-position of 1,3-cyclopentanedione using a recent protocol developed by Ramachary et al., and on a cross-coupling metathesis to access conjugate dienone system. In conclusion, this strategy permitted access to B1- and L1-PhytoPs in a relative short sequence process, and afford the possibility to easily develop analogs of PhytoPs.

  18. Production of exotic, short lived carbon isotopes in ISOL-type facilities

    CERN Document Server

    Franberg, Hanna; Köster, Ulli; Ammann, Markus

    2008-01-01

    The beam intensities of short-lived carbon isotopes at Isotope Separation On-Line (ISOL) facilities have been limited in the past for technical reasons. The production of radioactive ion beams of carbon isotopes is currently of high interest for fundamental nuclear physics research. To produce radioactive ions a target station consisting of a target in a container connected to an ion source via a transfer line is commonly used. The target is heated to vaporize the product for transport. Carbon in elementary form is a very reactive element and react strongly with hot metal surfaces. Due to the strong chemisorption interaction, in the target and ion source unit, the atoms undergo significant retention on their way from the target to the ion source. Due to this the short lived isotopes decays and are lost leading to low ion yields. A first approach to tackle these limitations consists of incorporating the carbon atoms into less reactive molecules and to use materials for the target housing and the transfer line ...

  19. Analysis of Task Types and Error Types of the Human Actions Involved in the Human-related Unplanned Reactor Trip Events

    International Nuclear Information System (INIS)

    Kim, Jae Whan; Park, Jin Kyun; Jung, Won Dea

    2008-02-01

    This report provides the task types and error types involved in the unplanned reactor trip events that have occurred during 1986 - 2006. The events that were caused by the secondary system of the nuclear power plants amount to 67 %, and the remaining 33 % was by the primary system. The contribution of the activities of the plant personnel was identified as the following order: corrective maintenance (25.7 %), planned maintenance (22.8 %), planned operation (19.8 %), periodic preventive maintenance (14.9 %), response to a transient (9.9 %), and design/manufacturing/installation (9.9%). According to the analysis of error modes, the error modes such as control failure (22.2 %), wrong object (18.5 %), omission (14.8 %), wrong action (11.1 %), and inadequate (8.3 %) take up about 75 % of all the unplanned trip events. The analysis of the cognitive functions involved showed that the planning function makes the highest contribution to the human actions leading to unplanned reactor trips, and it is followed by the observation function (23.4%), the execution function (17.8 %), and the interpretation function (10.3 %). The results of this report are to be used as important bases for development of the error reduction measures or development of the error mode prediction system for the test and maintenance tasks in nuclear power plants

  20. Analysis of Task Types and Error Types of the Human Actions Involved in the Human-related Unplanned Reactor Trip Events

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Whan; Park, Jin Kyun; Jung, Won Dea

    2008-02-15

    This report provides the task types and error types involved in the unplanned reactor trip events that have occurred during 1986 - 2006. The events that were caused by the secondary system of the nuclear power plants amount to 67 %, and the remaining 33 % was by the primary system. The contribution of the activities of the plant personnel was identified as the following order: corrective maintenance (25.7 %), planned maintenance (22.8 %), planned operation (19.8 %), periodic preventive maintenance (14.9 %), response to a transient (9.9 %), and design/manufacturing/installation (9.9%). According to the analysis of error modes, the error modes such as control failure (22.2 %), wrong object (18.5 %), omission (14.8 %), wrong action (11.1 %), and inadequate (8.3 %) take up about 75 % of all the unplanned trip events. The analysis of the cognitive functions involved showed that the planning function makes the highest contribution to the human actions leading to unplanned reactor trips, and it is followed by the observation function (23.4%), the execution function (17.8 %), and the interpretation function (10.3 %). The results of this report are to be used as important bases for development of the error reduction measures or development of the error mode prediction system for the test and maintenance tasks in nuclear power plants.

  1. Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.

    Directory of Open Access Journals (Sweden)

    Josep M Mercader

    Full Text Available Type 2 Diabetes (T2D is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. There is growing evidence supporting the notion that a crosstalk between mitochondria and the insulin signaling cascade could be involved in the etiology of T2D and insulin resistance. In this study we investigated the molecular basis of this crosstalk by using systems biology approaches. We combined, filtered, and interrogated different types of functional interaction data, such as direct protein-protein interactions, co-expression analyses, and metabolic and signaling dependencies. As a result, we constructed the mitochondria-insulin (MITIN network, which highlights 286 genes as candidate functional linkers between these two systems. The results of internal gene expression analysis of three independent experimental models of mitochondria and insulin signaling perturbations further support the connecting roles of these genes. In addition, we further assessed whether these genes are involved in the etiology of T2D using the genome-wide association study meta-analysis from the DIAGRAM consortium, involving 8,130 T2D cases and 38,987 controls. We found modest enrichment of genes associated with T2D amongst our linker genes (p = 0.0549, including three already validated T2D SNPs and 15 additional SNPs, which, when combined, were collectively associated to increased fasting glucose levels according to MAGIC genome wide meta-analysis (p = 8.12×10(-5. This study highlights the potential of combining systems biology, experimental, and genome-wide association data mining for identifying novel genes and related variants that increase vulnerability to complex diseases.

  2. INVOLVEMENT OF “TYPE-1 HERPES SIMPLEX” IN THE ETIOPATHOGENY OF THE GINGIVAL-PERIODONTAL DISEASES

    Directory of Open Access Journals (Sweden)

    Simona Ionela GRIGORAS

    2012-06-01

    Full Text Available Scope of the study: The present clinico-statistical study aimed at evaluating the oral manifestations determined by viral infections, especially herpes virusi, in correlation with some general symptoms and demographic characteristics. Materials and method: 68 cases of herpetic gingivo-stomatitis treated in the Clinical Hospital of Infectious Diseases of Ia[i have been investigated between January 1, 2010 – December 31, 2010. The oral clinical investigations, developed in the Clinics of Infectious Diseases and in the Department of Periodontology, aimed at evaluating the occurrence and evolution of the oral manifestations characteristic to this type of viral infections. Results and discussion: The oral manifestations observed within the experimental group had a polymorphous character. At group level, a relatively high number of patients (40.2% showed no oral lesions in the moment of the clinical examination, the remaining cases (49.8% evidencing more or less specific oral manifestations for the viral pathology involved in the debut and evolution of the disease under consideration. 13 cases (representing 9.0% of the total group evidenced oral lesions of ulceration and vesicle type, and 25 cases (13.6% showed lesion elements of exclusively vesicle type. Conclusions: The clinical-statistical study on the incidence and characteristics of the oral manifestations of the viral infection with type-1 herpes virus, clinically manifested, as well, at the level of the gingival mucous membrane, evidenced the constant presence of a higher incidence of this type of virusi in the population, as well as the polymorphous character of the oral lesions.

  3. Dopamine D2 Receptor Is Involved in Alleviation of Type II Collagen-Induced Arthritis in Mice.

    Science.gov (United States)

    Lu, Jian-Hua; Liu, Yi-Qian; Deng, Qiao-Wen; Peng, Yu-Ping; Qiu, Yi-Hua

    2015-01-01

    Human and murine lymphocytes express dopamine (DA) D2-like receptors including DRD2, DRD3, and DRD4. However, their roles in rheumatoid arthritis (RA) are less clear. Here we showed that lymphocyte DRD2 activation alleviates both imbalance of T-helper (Th)17/T-regulatory (Treg) cells and inflamed symptoms in a mouse arthritis model of RA. Collagen-induced arthritis (CIA) was prepared by intradermal injection of chicken collagen type II (CII) in tail base of DBA/1 mice or Drd2 (-/-) C57BL/6 mice. D2-like receptor agonist quinpirole downregulated expression of proinflammatory Th17-related cytokines interleukin- (IL-) 17 and IL-22 but further upregulated expression of anti-inflammatory Treg-related cytokines transforming growth factor- (TGF-) β and IL-10 in lymphocytes in vitro and in ankle joints in vivo in CIA mice. Quinpirole intraperitoneal administration reduced both clinical arthritis score and serum anti-CII IgG level in CIA mice. However, Drd2 (-/-) CIA mice manifested more severe limb inflammation and higher serum anti-CII IgG level and further upregulated IL-17 and IL-22 expression and downregulated TGF-β and IL-10 expression than wild-type CIA mice. In contrast, Drd1 (-/-) CIA mice did not alter limb inflammation or anti-CII IgG level compared with wild-type CIA mice. These results suggest that DRD2 activation is involved in alleviation of CIA symptoms by amelioration of Th17/Treg imbalance.

  4. The Wheat E Subunit of V-Type H+-ATPase Is Involved in the Plant Response to Osmotic Stress

    Directory of Open Access Journals (Sweden)

    Xiao-Hong Zhang

    2014-09-01

    Full Text Available The vacuolar type H+-ATPase (V-type H+-ATPase plays important roles in establishing an electrochemical H+-gradient across tonoplast, energizing Na+ sequestration into the central vacuole, and enhancing salt stress tolerance in plants. In this paper, a putative E subunit of the V-type H+-ATPase gene, W36 was isolated from stress-induced wheat de novo transcriptome sequencing combining with 5'-RACE and RT-PCR methods. The full-length of W36 gene was 1097 bp, which contained a 681 bp open reading frame (ORF and encoded 227 amino acids. Southern blot analysis indicated that W36 was a single-copy gene. The quantitative real-time PCR (qRT-PCR analysis revealed that the expression level of W36 could be upregulated by drought, cold, salt, and exogenous ABA treatment. A subcellular localization assay showed that the W36 protein accumulated in the cytoplasm. Isolation of the W36 promoter revealed some cis-acting elements responding to abiotic stresses. Transgenic Arabidopsis plants overexpressing W36 were enhanced salt and mannitol tolerance. These results indicate that W36 is involved in the plant response to osmotic stress.

  5. Scaled Facility Design Approach for Pool-Type Lead-Bismuth Eutectic Cooled Small Modular Reactor Utilizing Natural Circulation

    Energy Technology Data Exchange (ETDEWEB)

    Park, Sangrok; Shin, Yong-Hoon; Lee, Jueun; Hwang, Il Soon [Seoul National University, Seoul (Korea, Republic of)

    2015-10-15

    In low carbon era, nuclear energy is the most prominent energy source of electricity. For steady ecofriendly nuclear energy supply, Generation IV reactors which are future nuclear reactor require safety, sustainability, economics and non-proliferation as four criteria. Lead cooled fast reactor (LFR) is one of these reactor type and Generation IV international forum (GIF) adapted three reference LFR systems which are a small and movable systems with long life without refueling, intermediate size and huge electricity generation system for power grid. NUTRECK (Nuclear Transmutation Energy Center of Korea) has been designed reactor called URANUS (Ubiquitous, Rugged, Accident-forgiving, Non-proliferating, and Ultra-lasting Sustainer) which is small modular reactor and using lead-bismuth eutectic coolant. To prove natural circulation capability of URANUS and analyze design based accidents, scaling mock-up experiment facility will be constructed. In this paper, simple specifications of URANUS will be presented. Then based on this feature, scaling law and scaled facility design results are presented. To validate safety feature and thermodynamics characteristic of URANUS, scaled mockup facility of URANUS is designed based on the scaling law. This mockup adapts two area scale factors, core and lower parts of mock-up are scaled for 3D flow experiment. Upper parts are scaled different size to reduce electricity power and LBE tonnage. This hybrid scaling method could distort some thermal-hydraulic parameters, however, key parameters for experiment will be matched for up-scaling. Detailed design of mock-up will be determined through iteration for design optimization.

  6. Comparison of mass balance, energy consumption and cost of composting facilities for different types of organic waste

    International Nuclear Information System (INIS)

    Zhang Huijun; Matsuto, Toshihiko

    2011-01-01

    Mass balance, energy consumption and cost are basic pieces of information necessary for selecting a waste management technology. In this study, composting facilities that treat different types of organic waste were studied by questionnaire survey and via a chemical analysis of material collected at the facilities. The mass balance was calculated on a dry weight basis because the moisture content of organic waste was very high. Even though the ratio of bulking material to total input varied in the range 0-65% on a dry basis, the carbon and ash content, carbon/nitrogen ratio, heavy metal content and inorganic nutrients in the compost were clearly influenced by the different characteristics of the input waste. The use of bulking material was not correlated with ash or elemental content in the compost. The operating costs were categorised into two groups. There was some economy of scale for wages and maintenance cost, but the costs for electricity and fuel were proportional to the amount of waste. Differences in operating costs can be explained by differences in the process characteristics.

  7. A nuclear desalination complex with a VK-300 boiling type reactor facility

    International Nuclear Information System (INIS)

    Kuznetzov, Y.N.; Mishanina, Y.A.; Romenkov, A.A.

    2004-01-01

    RDIPE has developed a detailed design of an enhanced safety nuclear steam supply system (NSSS) with a VK-300 boiling water reactor for combined heat and power generation. The thermal power of the reactor is 750 MW. The maximum electrical power in the condensation mode is 250 MWe. The maximum heat generation capacity of 400 Gcal/h is reached at 150 MWe. This report describes, in brief, the basic technical concepts for the VK-300 NSSS and the power unit, with an emphasis on enhanced safety and good economic performance. With relatively small power, good technical and economic performance of the VK-300 reactor that is a base for the desalination complex is attained through: reduced capital costs of the nuclear plant construction thanks to technical approaches ensuring maximum simplicity of the reactor design and the NSSS layout; a single-circuit power unit configuration (reactor-turbine) excluding expensive equipment with a lot of metal, less pipelines and valves; reduced construction costs of the basic buildings thanks to reduced construction volumes due to rational arrangement concepts; higher reliability of equipment and reduced maintenance and repair costs; longer reactor design service life of up to 60 years; selection of the best reactor and desalination equipment interface pattern. The report considers the potential application of the VK-300 reactor as a source of energy for distillation desalination units. The heat from the reactor is transferred to the desalination unit via an intermediate circuit. Comparison is made between variants of the reactor integration with desalination units of the following types: multi-stage flash (MSF technology); multi-effect distillation horizontal-tube film units of the DOU GTPA type (MED technology). The NDC capacity with the VK-300 reactor, in terms of distillate, will be more than 200,000 m 3 /day, with the simultaneous output of electric power from the turbine generator buses of around 150 MWe. The variants of the

  8. Facile synthesis of nanorod-type graphitic carbon nitride/Fe2O3 composite with enhanced photocatalytic performance

    International Nuclear Information System (INIS)

    Wang, Jiangpeng; Li, Changqing; Cong, Jingkun; Liu, Ziwei; Zhang, Hanzhuo; Liang, Mei; Gao, Junkuo; Wang, Shunli; Yao, Juming

    2016-01-01

    Here we report a facile synthesis of nanorod-type graphitic carbon nitride/Fe 2 O 3 composite (Fe 2 O 3 -g-C 3 N 4 ) by using Fe-melamine supramolecular framework as precursor. The chemical and optical properties of the nanocomposites are well-characterized. The Fe 2 O 3 -g-C 3 N 4 nanocomposite demonstrated excellent photocatalytic activities under visible light due to the efficient utilization of sunlight and the construction of Z-scheme electron transfer pathway. The results indicated that it could be a promising approach for the preparation of efficient g-C 3 N 4 nanocomposites photocatalysts by using metal-melamine supramolecular framework as precursors. - Graphical abstract: Nanorod-type graphitic carbon nitride/Fe 2 O 3 composite (Fe 2 O 3 -g-C 3 N 4 ) was synthesized by using Fe-melamine supramolecular framework as precursor. The Fe 2 O 3 -g-C 3 N 4 nanocomposite demonstrated excellent photocatalytic activities under visible light. Display Omitted - Highlights: • Nanorod-type graphitic carbon nitride/Fe 2 O 3 composite (Fe 2 O 3 -g-C 3 N 4 ) was synthesized. • Fe 2 O 3 -g-C 3 N 4 showed strong optical absorption in the visible-light region. • The Fe 2 O 3 -g-C 3 N 4 nanocomposite demonstrated excellent photocatalytic activities.

  9. Qualification testing facility for type A, B and C packages to be used for transport and storage of radioactive materials

    International Nuclear Information System (INIS)

    Vieru, G.; Nistor, V.; Vasile, A.; Cojocaru, V.

    2009-01-01

    In accordance with the Economic Commission for Europe-Committee on inland transport (ADR- European Agreement-concerning the international carriage of dangerous goods by road, 2007 Edition) the Safety and Security of the dangerous goods class No. 7 - Radioactive Materials during transport in all different modes - by road, by rail, by sea, by inland rivers or by air - have to be ensured at a very high level. The radioactive materials (RAM) packaging have to comply to all transport conditions, routine or in accident conditions, possibly to occur during transportation operations. It is well known that the safety in the transport of RAM is dependent on packaging appropriate for the contents being shipped rather than on operational and/or administrative actions required for the package. The quality of these packages - type A, B or C has to be proved by performing qualification tests in accordance with the Romanian nuclear regulation conditions provided by CNCAN Order no. 357/22.12.2005- N orms for a Safe Transport of Radioactive Material , the IAEA Vienna Recommendation (1, 2) stipulated in the Safety standard TS-R-1- Regulation for the Safe Transport of Radioactive Material, 2005 Edition, and other applicable international recommendations. The paper will describe the components of the designed testing facilities, and the qualification testing to be performed for all type A, B and C packages subjected to the testing Quality assurance and quality controls measures taken in order to meet technical specification provided by the design are also presented and commented. The paper concludes that the new Romanian Testing Facilities for RAM packages will comply with the national safe standards as well as with the IAEA applicable recommendation provided by the TS-R-1 safety standard. (authors)

  10. Facile synthesis of B-type carbonated nanoapatite with tailored microstructure

    Energy Technology Data Exchange (ETDEWEB)

    Gualtieri, Magdalena Lassinantti, E-mail: magdalena.gualtieri@unimore.it [Dipartimento Ingegneria “Enzo Ferrari”, Università degli studi di Modena e Reggio Emilia, I-41125 Modena (Italy); Romagnoli, Marcello, E-mail: marcello.romagnoli@unimore.it [Dipartimento Ingegneria “Enzo Ferrari”, Università degli studi di Modena e Reggio Emilia, I-41125 Modena (Italy); Hanuskova, Miriam, E-mail: Miriam.hanuskova@unimore.it [Dipartimento Ingegneria “Enzo Ferrari”, Università degli studi di Modena e Reggio Emilia, I-41125 Modena (Italy); Fabbri, Elena, E-mail: Elena.fabbri@unimore.it [Dipartimento Ingegneria “Enzo Ferrari”, Università degli studi di Modena e Reggio Emilia, I-41125 Modena (Italy); Gualtieri, Alessandro F., E-mail: Alessandro.gualtieri@unimore.it [Dipartimento di Scienze Chimiche e Geologiche, Università degli studi di Modena e Reggio Emilia, I-41121 Modena (Italy)

    2014-12-15

    Nanolime and a phosphate-based chelating agent were used to synthesize B-type carbonated apatite. Developed Rietveld refinement strategies allowed one to determine process yield, product crystallinity as well as structural (unit cell) and microstructural (size, strain) parameters. The effect of synthesis temperature (20–60 °C) as well as Ca/P ratio (1.5–2.5) and solid content (10–30 wt%) of the starting batch on these properties were investigated. FTIR, TEM and gas adsorption data provided supporting evidence. The process yield was 42–60 wt% and found to be governed by the Ca/P ratio. The purified products had high specific surface area (107–186 m{sup 2}/g) and crystallinity (76–97%). The unit cell parameters, correlated to the degree of structural carbonate, were sensitive to the Ca/P ratio. Instead, temperature governed the microstructural parameters. Less strained and larger crystals were obtained at higher temperatures. Long-term aging up to 6 months at 20 °C compensated for higher crystal growth kinetics at higher temperature. - Graphical abstract: Controlled synthesis of carbonated apatite at moderate temperatures using nanolime and sodiumhexametaphosphate as starting reagent. - Highlights: • Chemical synthesis of nano-sized apatite with tailored microstructure was performed. • Colloidal Ca(OH){sub 2} and a phosphorus-based chelating agents were used as reagents. • The method is simple and reproducible which facilitate industrial process scale-up. • Rietveld refinement strategies for product characterization were developed. • Rietveld analyses provided yield, microstructural and structure information.

  11. Facile synthesis of B-type carbonated nanoapatite with tailored microstructure

    International Nuclear Information System (INIS)

    Gualtieri, Magdalena Lassinantti; Romagnoli, Marcello; Hanuskova, Miriam; Fabbri, Elena; Gualtieri, Alessandro F.

    2014-01-01

    Nanolime and a phosphate-based chelating agent were used to synthesize B-type carbonated apatite. Developed Rietveld refinement strategies allowed one to determine process yield, product crystallinity as well as structural (unit cell) and microstructural (size, strain) parameters. The effect of synthesis temperature (20–60 °C) as well as Ca/P ratio (1.5–2.5) and solid content (10–30 wt%) of the starting batch on these properties were investigated. FTIR, TEM and gas adsorption data provided supporting evidence. The process yield was 42–60 wt% and found to be governed by the Ca/P ratio. The purified products had high specific surface area (107–186 m 2 /g) and crystallinity (76–97%). The unit cell parameters, correlated to the degree of structural carbonate, were sensitive to the Ca/P ratio. Instead, temperature governed the microstructural parameters. Less strained and larger crystals were obtained at higher temperatures. Long-term aging up to 6 months at 20 °C compensated for higher crystal growth kinetics at higher temperature. - Graphical abstract: Controlled synthesis of carbonated apatite at moderate temperatures using nanolime and sodiumhexametaphosphate as starting reagent. - Highlights: • Chemical synthesis of nano-sized apatite with tailored microstructure was performed. • Colloidal Ca(OH) 2 and a phosphorus-based chelating agents were used as reagents. • The method is simple and reproducible which facilitate industrial process scale-up. • Rietveld refinement strategies for product characterization were developed. • Rietveld analyses provided yield, microstructural and structure information

  12. Clathrin- and Caveolin-Independent Entry of Human Papillomavirus Type 16—Involvement of Tetraspanin-Enriched Microdomains (TEMs)

    Science.gov (United States)

    Spoden, Gilles; Freitag, Kirsten; Husmann, Matthias; Boller, Klaus; Sapp, Martin; Lambert, Carsten; Florin, Luise

    2008-01-01

    Background Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. Methodology/Principal Findings Using immunofluorescence and infection studies we show in contrast to published data that infectious entry of HPV16 occurs in a clathrin- and caveolin-independent manner. Inhibition of clathrin- and caveolin/raft-dependent endocytic pathways by dominant-negative mutants and siRNA-mediated knockdown, as well as inhibition of dynamin function, did not impair infection. Rather, we provide evidence for involvement of tetraspanin-enriched microdomains (TEMs) in HPV16 endocytosis. Following cell attachment, HPV16 particles colocalized with the tetraspanins CD63 and CD151 on the cell surface. Notably, tetraspanin-specific antibodies and siRNA inhibited HPV16 cell entry and infection, confirming the importance of TEMs for infectious endocytosis of HPV16. Conclusions/Significance Tetraspanins fulfill various roles in the life cycle of a number of important viral pathogens, including human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, their involvement in endocytosis of viral particles has not been proven. Our data indicate TEMs as a novel clathrin- and caveolin-independent invasion route for viral pathogens and especially HPV16. PMID:18836553

  13. Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs.

    Directory of Open Access Journals (Sweden)

    Gilles Spoden

    Full Text Available BACKGROUND: Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16, the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. METHODOLOGY/PRINCIPAL FINDINGS: Using immunofluorescence and infection studies we show in contrast to published data that infectious entry of HPV16 occurs in a clathrin- and caveolin-independent manner. Inhibition of clathrin- and caveolin/raft-dependent endocytic pathways by dominant-negative mutants and siRNA-mediated knockdown, as well as inhibition of dynamin function, did not impair infection. Rather, we provide evidence for involvement of tetraspanin-enriched microdomains (TEMs in HPV16 endocytosis. Following cell attachment, HPV16 particles colocalized with the tetraspanins CD63 and CD151 on the cell surface. Notably, tetraspanin-specific antibodies and siRNA inhibited HPV16 cell entry and infection, confirming the importance of TEMs for infectious endocytosis of HPV16. CONCLUSIONS/SIGNIFICANCE: Tetraspanins fulfill various roles in the life cycle of a number of important viral pathogens, including human immunodeficiency virus (HIV and hepatitis C virus (HCV. However, their involvement in endocytosis of viral particles has not been proven. Our data indicate TEMs as a novel clathrin- and caveolin-independent invasion route for viral pathogens and especially HPV16.

  14. Clathrin- and caveolin-independent entry of human papillomavirus type 16--involvement of tetraspanin-enriched microdomains (TEMs).

    Science.gov (United States)

    Spoden, Gilles; Freitag, Kirsten; Husmann, Matthias; Boller, Klaus; Sapp, Martin; Lambert, Carsten; Florin, Luise

    2008-10-02

    Infectious entry of human papillomaviruses into their host cells is an important step in the viral life cycle. For cell binding these viruses use proteoglycans as initial attachment sites. Subsequent transfer to a secondary receptor molecule seems to be involved in virus uptake. Depending on the papillomavirus subtype, it has been reported that entry occurs by clathrin- or caveolin-mediated mechanisms. Regarding human papillomavirus type 16 (HPV16), the primary etiologic agent for development of cervical cancer, clathrin-mediated endocytosis was described as infectious entry pathway. Using immunofluorescence and infection studies we show in contrast to published data that infectious entry of HPV16 occurs in a clathrin- and caveolin-independent manner. Inhibition of clathrin- and caveolin/raft-dependent endocytic pathways by dominant-negative mutants and siRNA-mediated knockdown, as well as inhibition of dynamin function, did not impair infection. Rather, we provide evidence for involvement of tetraspanin-enriched microdomains (TEMs) in HPV16 endocytosis. Following cell attachment, HPV16 particles colocalized with the tetraspanins CD63 and CD151 on the cell surface. Notably, tetraspanin-specific antibodies and siRNA inhibited HPV16 cell entry and infection, confirming the importance of TEMs for infectious endocytosis of HPV16. Tetraspanins fulfill various roles in the life cycle of a number of important viral pathogens, including human immunodeficiency virus (HIV) and hepatitis C virus (HCV). However, their involvement in endocytosis of viral particles has not been proven. Our data indicate TEMs as a novel clathrin- and caveolin-independent invasion route for viral pathogens and especially HPV16.

  15. Evaluation of the Cable Types for Safety Requirements during Fire Conditions in Nuclear Facility

    International Nuclear Information System (INIS)

    Al-kattan, W.A.

    2015-01-01

    In Nuclear Power Plants (NPPs), the fire in cables causes many dangerous events in electrical or mechanical operations causing a nuclear reactor melt down. Main Control Room (MCR) in nuclear power plants have therefore, special concern in the fire protection systems. The Nuclear International Atomic Energy Agency (IAEA) has promoted the use of risk-informed and performance based methods for fire protection. These methods affirm the relevant needs to develop realistic methods to quantify the risk of fire to NPPs safety. The recent electrical cable testing has been carried out to provide empirical data on the failure modes and likelihood of fire-induced damage. In this thesis, will use fire modeling to develop fire probabilistic safety assessment to estimate the likelihood of fire induced cable damage given a specified fire profile. The objective of this work is to provide a comprehensive evaluation of the most recent fire-induced circuit failure due to different cables type that used inside the NPPs by simulation using fire modeling. One of this work scope is to suggest a suitable cable insulation material especially in case of the thermal failure thresholds, for developing the electrical cable thermal fragility distributions and evaluate parameters that influence fire-induced circuit failure modes. The main control room is implementing using the CFAST (fire simulation package). The simulation results represent the full development fire temperature and heat flux as well as the output gases. The results can be used as the basic parameters of the cables comparison and then evaluation.The importance of these results are not only for evaluating the cables but one can efficiently use them to improve the whole NPPs safety levels. The gases results of the fire simulation inside the room are oxygen, carbon monoxide, carbon dioxide, and hydrogen chloride. These gases are being used lot achieving the healthy protection of NPPs. Finally, one can measure the healthy environment

  16. Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins

    Energy Technology Data Exchange (ETDEWEB)

    Maric, Martina; Haugo, Alison C. [Department of Microbiology, University of Iowa, Iowa City, IA 52242 (United States); Dauer, William [Department of Neurology, University of Michigan, Ann Arbor, MI 48109 (United States); Johnson, David [Department of Microbiology and Immunology, Oregon Health Sciences University, Portland, OR 97201 (United States); Roller, Richard J., E-mail: richard-roller@uiowa.edu [Department of Microbiology, University of Iowa, Iowa City, IA 52242 (United States)

    2014-07-15

    Herpesvirus infection reorganizes components of the nuclear lamina usually without loss of integrity of the nuclear membranes. We report that wild-type HSV infection can cause dissolution of the nuclear envelope in transformed mouse embryonic fibroblasts that do not express torsinA. Nuclear envelope breakdown is accompanied by an eight-fold inhibition of virus replication. Breakdown of the membrane is much more limited during infection with viruses that lack the gB and gH genes, suggesting that breakdown involves factors that promote fusion at the nuclear membrane. Nuclear envelope breakdown is also inhibited during infection with virus that does not express UL34, but is enhanced when the US3 gene is deleted, suggesting that envelope breakdown may be enhanced by nuclear lamina disruption. Nuclear envelope breakdown cannot compensate for deletion of the UL34 gene suggesting that mixing of nuclear and cytoplasmic contents is insufficient to bypass loss of the normal nuclear egress pathway. - Highlights: • We show that wild-type HSV can induce breakdown of the nuclear envelope in a specific cell system. • The viral fusion proteins gB and gH are required for induction of nuclear envelope breakdown. • Nuclear envelope breakdown cannot compensate for deletion of the HSV UL34 gene.

  17. Dopamine D2 Receptor Is Involved in Alleviation of Type II Collagen-Induced Arthritis in Mice

    Directory of Open Access Journals (Sweden)

    Jian-Hua Lu

    2015-01-01

    Full Text Available Human and murine lymphocytes express dopamine (DA D2-like receptors including DRD2, DRD3, and DRD4. However, their roles in rheumatoid arthritis (RA are less clear. Here we showed that lymphocyte DRD2 activation alleviates both imbalance of T-helper (Th17/T-regulatory (Treg cells and inflamed symptoms in a mouse arthritis model of RA. Collagen-induced arthritis (CIA was prepared by intradermal injection of chicken collagen type II (CII in tail base of DBA/1 mice or Drd2−/− C57BL/6 mice. D2-like receptor agonist quinpirole downregulated expression of proinflammatory Th17-related cytokines interleukin- (IL- 17 and IL-22 but further upregulated expression of anti-inflammatory Treg-related cytokines transforming growth factor- (TGF- β and IL-10 in lymphocytes in vitro and in ankle joints in vivo in CIA mice. Quinpirole intraperitoneal administration reduced both clinical arthritis score and serum anti-CII IgG level in CIA mice. However, Drd2−/− CIA mice manifested more severe limb inflammation and higher serum anti-CII IgG level and further upregulated IL-17 and IL-22 expression and downregulated TGF-β and IL-10 expression than wild-type CIA mice. In contrast, Drd1−/− CIA mice did not alter limb inflammation or anti-CII IgG level compared with wild-type CIA mice. These results suggest that DRD2 activation is involved in alleviation of CIA symptoms by amelioration of Th17/Treg imbalance.

  18. Evaluation on applicability of construction methods and construction quality of low-diffusion layer of cavern type radioactive waste disposal facility

    International Nuclear Information System (INIS)

    Takechi, Shin-ichi; Yokozeki, Kosuke; Terada, Kenji; Akiyama, Yoshihiro; Yada, Tsutomu; Tsuji, Yukikazu

    2014-01-01

    A performance verification experiment of cavern type radioactive waste disposal facility with a real scale construction is being conducted to evaluate the applicability of proposed construction methods and construction quality of the facility. In this paper, we confirmed that the low-diffusion layer, which is one of the cementitious materials based members, could be filled with mortar from end to end of the member; cracks of low-diffusion layer would not affect the long-term safety evaluation of the facility. And also we figured out the relationship between the material strength and the accumulated temperature, relationship between diffusion coefficient and porosity of low-diffusion layer. (author)

  19. Fiscal 1997 survey report. Basic survey on trends of waste use type production facilities and waste fuel production facilities; 1997 nendo chosa hokokusho. Haikibutsu riyogata seizo shisetsu oyobi haikibutsu nenryo seizo shisetsu doko kiso chosa hokokusho

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    This survey was made to obtain the basic data for future spread and promotion of No.6 type (waste use type production facilities) and No.7 type (waste fuel production facilities) which were added to the objects having been subsidized since fiscal 1997 under `the environmental harmony type energy community project.` In the former, the kiln in the cement industry and the blast furnace in the steel industry can be extremely large places to receive waste plastic since the facilities are distributed in every area and the treatment capacity is large. However, the effective collection, transportation and sorting of large quantity of waste plastic, especially the problem of removal of vinyl chloride, is a big bottleneck. As to the use of waste plastic using gasification technology, there are no actual results on the commercial basis. That is, however, appropriate for treatment of the waste difficult in treatment, and can be expected of the usage in the chemical industry. In the latter, in the facilities using industrial waste raw materials as fuel, solidification and liquefaction are both operated on a commercial basis. In relation to the solidification and use as fuel of general waste, the treatment of combustion ash is preventing the expansion of use of waste in the industrial field because of a large quantity of chlorine included in the products. 92 refs., 54 figs., 35 tabs.

  20. Injury/Fatality-Causing Incidents Involving the Rearward Movement of Agricultural Machinery: Types, Causes, and Preventive Measures

    Directory of Open Access Journals (Sweden)

    Shawn G. Ehlers

    2017-02-01

    Full Text Available The research reported here sought to more fully understand the types and causative factors of injury/fatality incidents resulting from the rearward-movement of tractors and other self-propelled agricultural machinery, with the view that such findings might lead to the development, improvement, and/or better utilization of safety procedures, design principles, and technologies that would prevent—or at least markedly reduce—their occurrence. Thus, the scope of this study focused only on rearward-travel (not mechanical malfunction incidents, and principally on agricultural equipment (although cases involving similar equipment in industrial or construction settings were also drawn upon. Applying these two criteria, a search of published and online sources uncovered more than 100 documented cases, 35 of which could clearly be identified as rearward-movement incidents, of which 28 (80% were fatal. Each of these 35 cases were then assessed, based on the type of machine, type of worksite, and type/description of incident (i.e., ‘scenario’, which fell into one of three distinct categories or classifications—(1 co-worker run over/crushed/otherwise injured because operator loses visual contact with co-worker; (2 bystander run over/crushed/otherwise injured because operator is unaware of bystander’s presence; and (3 operator run over/crushed/otherwise injured because operator loses visual contact with, or is unaware of, a stationary object or a hazard. Then, from each scenario, a representative incident (i.e., case study was selected for a more in-depth analysis. The collective findings, from these three case studies and all 35 machinery rearward-movement incidents, were as follows: (1 The ‘victim’ could be the machine operator as well as a co-worker or a bystander; (2 The specific site of the co-worker or bystander injury/fatality was at the base of the machine’s rear tires or tracks, at the hitching point, or behind a towed implement; (3

  1. A L-type lectin gene is involved in the response to hormonal treatment and water deficit in Volkamer lemon.

    Science.gov (United States)

    Vieira, Dayse Drielly Sousa Santana; Emiliani, Giovanni; Bartolini, Paola; Podda, Alessandra; Centritto, Mauro; Luro, François; Carratore, Renata Del; Morillon, Raphaël; Gesteira, Abelmon; Maserti, Biancaelena

    2017-11-01

    Combination of biotic and abiotic stress is a major challenge for crop and fruit production. Thus, identification of genes involved in cross-response to abiotic and biotic stress is of great importance for breeding superior genotypes. Lectins are glycan-binding proteins with a functions in the developmental processes as well as in the response to biotic and abiotic stress. In this work, a lectin like gene, namely ClLectin1, was characterized in Volkamer lemon and its expression was studied in plants exposed to either water stress, hormonal elicitors (JA, SA, ABA) or wounding to understand whether this gene may have a function in the response to multiple stress combination. Results showed that ClLectin1 has 100% homology with a L-type lectin gene from C. sinensis and the in silico study of the 5'UTR region showed the presence of cis-responsive elements to SA, DRE2 and ABA. ClLectin1 was rapidly induced by hormonal treatments and wounding, at local and systemic levels, suggesting an involvement in defence signalling pathways and a possible role as fast detection biomarker of biotic stress. On the other hand, the induction of ClLectin1 by water stress pointed out a role of the gene in the response to drought. The simultaneous response of ClLectin1 expression to water stress and SA treatment could be further investigated to assess whether a moderate drought stress may be useful to improve citrus performance by stimulating the SA-dependent response to biotic stress. Copyright © 2017 Elsevier GmbH. All rights reserved.

  2. Cardiac Involvement in Myotonic Dystrophy Type 2 Patients With Preserved Ejection Fraction: Detection by Cardiovascular Magnetic Resonance.

    Science.gov (United States)

    Schmacht, Luisa; Traber, Julius; Grieben, Ulrike; Utz, Wolfgang; Dieringer, Matthias A; Kellman, Peter; Blaszczyk, Edyta; von Knobelsdorff-Brenkenhoff, Florian; Spuler, Simone; Schulz-Menger, Jeanette

    2016-07-01

    Myotonic dystrophy type 2 (DM2) is a genetic disorder characterized by skeletal muscle symptoms, metabolic changes, and cardiac involvement. Histopathologic alterations of the skeletal muscle include fibrosis and fatty infiltration. The aim of this study was to investigate whether subclinical cardiac involvement in DM2 is already detectable in preserved left ventricular function by cardiovascular magnetic resonance. Twenty-seven patients (mean age, 54±10 years; 20 females) with a genetically confirmed diagnosis of DM2 were compared with 17 healthy age- and sex-matched controls using a 1.5 T magnetic resonance imaging. For myocardial tissue differentiation, T1 and T2 mapping, fat/water-separated imaging, focal fibrosis imaging (late gadolinium enhancement [LGE]), and (1)H magnetic resonance spectroscopy were performed. Extracellular volume fraction was calculated. Conduction abnormalities were diagnosed based on Groh criteria. LGE located subepicardial basal inferolateral was detectable in 22% of the patients. Extracellular volume was increased in this region and in the adjacent medial inferolateral segment (P=0.03 compared with healthy controls). In 21% of patients with DM2, fat deposits were detectable (all women). The control group showed no abnormalities. Myocardial triglycerides were not different in LGE-positive and LGE-negative subjects (P=0.47). Six patients had indicators for conduction disease (60% of LGE-positive patients and 12.5% of LGE-negative patients). In DM2, subclinical myocardial injury was already detectable in preserved left ventricular ejection fraction. Extracellular volume was also increased in regions with no focal fibrosis. Myocardial fibrosis was related to conduction abnormalities. © 2016 American Heart Association, Inc.

  3. Decision-Making Involvement and Prediction of Adherence in Youth With Type 1 Diabetes: A Cohort Sequential Study.

    Science.gov (United States)

    Miller, Victoria A; Jawad, Abbas F

    2018-05-17

    To assess developmental trajectories of decision-making involvement (DMI), defined as the ways in which parents and children engage each other in decision-making about illness management, in youth with type 1 diabetes (T1D) and examine the effects of DMI on levels of and changes in adherence with age. Participants included 117 youth with T1D, enrolled at ages 8-16 years and assessed five times over 2 years. The cohort sequential design allowed for the approximation of the longitudinal curve from age 8 to 19 from overlapping cohort segments. Children and parents completed the Decision-Making Involvement Scale, which yields subscales for different aspects of DMI, and a self-report adherence questionnaire. Mixed-effects growth curve modeling was used for analysis, with longitudinal measures nested within participant and participants nested within cohort. Most aspects of DMI (Parent Express, Parent Seek, Child Express, and Joint) increased with child age; scores on some child report subscales (Parent Express, Child Seek, and Joint) decreased after age 12-14 years. After accounting for age, Child Seek, Child Express, and Joint were associated with overall higher levels of adherence in both child (estimates = 0.08-0.13, p < .001) and parent (estimates = 0.07- 0.13, p < .01) report models, but they did not predict changes in adherence with age. These data suggest that helping children to be more proactive in T1D discussions, by encouraging them to express their opinions, share information, and solicit guidance from parents, is a potential target for interventions to enhance effective self-management.

  4. Factors associated with adherence to diabetes care recommendations among children and adolescents with type 1 diabetes: a facility-based study in two urban diabetes clinics in Uganda

    Directory of Open Access Journals (Sweden)

    Kyokunzire C

    2018-03-01

    Full Text Available Catherine Kyokunzire,1 Nicholas Matovu2,3 1Department of Community Health and Behavioural Sciences, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda; 2Department of Community Health, Division of Noncommunicable Diseases, Ministry of Health – Uganda, Kampala, Uganda; 3Global Health Corps Fellowship Program 2017/2018, New York, NY, USA Purpose: The purpose of this study was to determine the level of adherence and the factors associated with adherence to diabetes care recommendations among type 1 diabetic children and adolescents at two urban diabetes clinics in Kampala, Uganda.Research design and methods: A facility-based cross-sectional study was carried out among 200 children and adolescents with type 1 diabetes at two major diabetes clinics in Kampala. Caretakers of the children and adolescents were interviewed using pretested questionnaires to provide information on sociodemographic characteristics, diabetes care, knowledge, attitudes, and adherence to diabetes care recommendations in type 1 diabetes. Prevalence rate ratios (PRRs at the 95% confidence interval (CI were used to establish the factors associated with adherence using modified Poisson regression, with robust standard errors. The data were analyzed by using STATA Version 13.0.Results: The overall prevalence of adherence to diabetes care recommendations was at 37%. However, evaluating adherence to specific treatment parameters showed that 52%, 76.5%, and 29.5% of the children and adolescents adhered to insulin, blood glucose monitoring, and dietary recommendations, respectively. In the final adjusted model, active diet monitoring (adjusted PRR [APRR]: 1.95; 95% CI: 1.01, 3.78, being under care of a sibling (APRR: 1.66; 95% CI: 1.61, 1.71, being under care of a married caretaker (APRR: 1.10; 95% CI: 1.05, 1.14 and a separated or divorced caretaker (APRR: 1.60; 95% CI: 1.12, 2.27, taking three or less tests of blood glucose per day (APRR: 0

  5. The effect of an education programme (MEDIAS 2 ICT) involving intensive insulin treatment for people with type 2 diabetes.

    Science.gov (United States)

    Hermanns, Norbert; Kulzer, Bernhard; Maier, Berthold; Mahr, Marina; Haak, Thomas

    2012-02-01

    In a randomized, multi-centre trial, the effect of an education programme (MEDIAS 2 ICT) involving intensive insulin treatment for people with type 2 diabetes was compared with an established education programme as an active comparator condition (ACC). We investigated whether MEDIAS 2 ICT was non-inferior to ACC in overall glycaemic control. Secondary outcomes were the diabetes-related distress, diabetes knowledge, quality of life, self-care behavior, lipids, blood pressure and weight. 186 subjects were randomized. After a six month follow-up the mean HbA1c decrease was 0.37% (from 8.2±1.1% to 7.8±1.5%) in the ACC and 0.63% (from 8.5±1.5% to 7.9±1.2%) in MEDIAS 2 ICT. The mean difference between both groups was -0.26% (95% CI -0.63 to -0.14) in favor of MEDIAS 2 ICT. This result was within the predefined limit for non-inferiority. Diabetes-related distress was significantly more reduced in MEDIAS 2 ICT (-3.4±7.1) than in ACC (0.4±9.0; p=0.31). MEDIAS 2 ICT is as effective in lowering HbA1c as previously established education programmes, but showed superiority in reducing diabetes-related distress. MEDIAS 2 ICT provides an alternative for education of people with type 2 diabetes treated by multiple injection therapy. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

  6. A CONTROVERSIAL ON THE DIAGNOSIS OF CHRONIC BULLOUS TYPE MUCOCUTANEOUS DISEASE INVOLVING ORAL MUCOSA (A CASE REPORT

    Directory of Open Access Journals (Sweden)

    Isadora Gracia

    2006-04-01

    Full Text Available A case of chronic bullous type mucocutaneous disease involving oral mucosa was reported from a 56 years old man with never healing oral ulcers and wound on the perianal skin for three years. There were also red and black spots on the limb and back skin and a lesion on nail. Painful oral lesion consisted of mucous erosion, desquamative gingivitis, and sloughing area on palate and tongue. The patient is diabetic. The first perianal skin diagnosis was granulomatous candidasis with differential diagnosis pemphigus vegetates and acuminarum condiloma. However the histopathologic examination did not support these diagnosis. After several histopathologic examinations, the latest perianal skin diagnosis was lichen planus with differential diagnosis granulomatous vasculitis, bowenoid papulosis and pyodema gangrenosum. Other skin diagnosis was erythema multiforme. Oral diagnosis was mucous membrane pemphigoid with differential diagnosis lichen planus, Behçet's syndrome and erythema multiforme. Oral histopathologic examinations showed a sub-epithelial blister, which supported mucous membrane pemphigoid. A lip balm, prednisone 5 mg oral rinse and multivitamins were given but oral improvement started after blood sugar level was controlled. Conclusion: It is not yet known whether skin and oral mucous lesions are from the same disease or not.

  7. Nuclear envelope breakdown induced by herpes simplex virus type 1 involves the activity of viral fusion proteins.

    Science.gov (United States)

    Maric, Martina; Haugo, Alison C; Dauer, William; Johnson, David; Roller, Richard J

    2014-07-01

    Herpesvirus infection reorganizes components of the nuclear lamina usually without loss of integrity of the nuclear membranes. We report that wild-type HSV infection can cause dissolution of the nuclear envelope in transformed mouse embryonic fibroblasts that do not express torsinA. Nuclear envelope breakdown is accompanied by an eight-fold inhibition of virus replication. Breakdown of the membrane is much more limited during infection with viruses that lack the gB and gH genes, suggesting that breakdown involves factors that promote fusion at the nuclear membrane. Nuclear envelope breakdown is also inhibited during infection with virus that does not express UL34, but is enhanced when the US3 gene is deleted, suggesting that envelope breakdown may be enhanced by nuclear lamina disruption. Nuclear envelope breakdown cannot compensate for deletion of the UL34 gene suggesting that mixing of nuclear and cytoplasmic contents is insufficient to bypass loss of the normal nuclear egress pathway. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. Cooling effects of artificial water facilities by using a moving type turbulence promoter; Kudo ranryu sokushintai ni yoru suireikyaku jikkenho

    Energy Technology Data Exchange (ETDEWEB)

    Miyake, K; Nomura, T; Nishimura, N; Iyota, H [Osaka City University, Osaka (Japan)

    1996-10-27

    Artificial water facilities present an effective means to alleviate trying micrometeorological phenomena such as warming of the urban space. For the reproduction of such an alleviating means by use of a model in a wind tunnel, a moving disturbance promoter (moving spire) was developed so as to render disturbances in a wind tunnel current similar in scale to ones in the real atmosphere, and an air current cooling experiment was conducted using a model fountain. The effort was intended for a small-size wind tunnel without a space large enough for disturbance promoter installation, and a moving type spire was developed for promoting disturbance effectively. The new spire is driven by a driving unit consisting of a motor and cam and can change its angle relative to the main current by 140{degree} at a rotation cycle of 1.7Hz., and this changes the flow direction of the main current periodically. As compared with the generally used combination of a roughness block and stationery spire, this new spire produced a disturbance intensity two times greater and a disturbance scale three times larger. When the disturbance intensity and scale were increased, the cooling characteristics of the air current changed in response to changes in the state of flow. 8 refs., 7 figs., 1 tab.

  9. Facile synthesis of pyrite-type binary nickel iron diselenides as efficient electrocatalyst for oxygen evolution reaction

    Energy Technology Data Exchange (ETDEWEB)

    Chi, Jing-Qi; Shang, Xiao [State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580 (China); Liang, Fei [State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580 (China); College of Science, China University of Petroleum (East China), Qingdao 266580 (China); Dong, Bin, E-mail: dongbin@upc.edu.cn [State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580 (China); College of Science, China University of Petroleum (East China), Qingdao 266580 (China); Li, Xiao; Liu, Yan-Ru; Yan, Kai-Li [State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580 (China); Gao, Wen-Kun [State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580 (China); College of Science, China University of Petroleum (East China), Qingdao 266580 (China); Chai, Yong-Ming [State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580 (China); Liu, Chen-Guang, E-mail: cgliu@upc.edu.cn [State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao 266580 (China)

    2017-04-15

    Highlights: • Binary pyrite-type Ni{sub 0.5}Fe{sub 0.5}Se{sub 2}/CFC was prepared by a facile two-step process. • The effect of Ni/Fe (Ni{sub x}Fe{sub 1-x}Se{sub 2} x = 0, 0.2, 0.5, 0.8, 1) on OER was investigated. • Ni{sub 0.5}Fe{sub 0.5}Se{sub 2}/CFC (x = 0.5) possesses the better electrocatalytic activity for OER. • The enhanced activity may be attributed to binary Ni{sub 0.5}Fe{sub 0.5}Se{sub 2} and CFC support. - Abstract: Pyrite-type binary nickel iron diselenides (Ni{sub 0.5}Fe{sub 0.5}Se{sub 2}) supported on carbon fiber cloth (CFC) as electrocatalysts for oxygen evolution reaction (OER) have been prepared by a facile two-step process. Firstly, binary Ni{sub 0.5}Fe{sub 0.5} hydroxide nanosheets have been electrodeposited on CFC. Secondly, a solvothermal selenization process has been used to convert Ni{sub 0.5}Fe{sub 0.5}/CFC into Ni{sub 0.5}Fe{sub 0.5}Se{sub 2}/CFC. XRD shows that Ni{sub 0.5}Fe{sub 0.5}Se{sub 2} on CFC has the typically octahedral crystalline. XPS proves the existence and valence of Ni, Fe and Se. SEM images show that Ni{sub 0.5}Fe{sub 0.5}Se{sub 2} has novel pyrite-type octahedral morphology with uniform size and good dispersion on the surface of CFC. SEM elemental mapping images confirm the good distribution of Ni, Fe, Se element on CFC. TEM and SAED provide the clear diffraction rings of octahedral Ni{sub 0.5}Fe{sub 0.5}Se{sub 2}, which is consistent with the results of XRD. Furtherly, the effect of different ratio of Ni/Fe (Ni{sub x}Fe{sub 1-x}Se{sub 2} x = 0, 0.2, 0.5, 0.8, 1) on OER performances has been systematically investigated. The electrochemical measurements results show that Ni{sub 0.5}Fe{sub 0.5}Se{sub 2}/CFC (x = 0.5) possesses the better electrocatalytic activity with the lower overpotential, Tafel slope and long-term stability than other samples. The enhanced activity of Ni{sub 0.5}Fe{sub 0.5}Se{sub 2}/CFC may be attributed to the intrinsic activity of binary Ni{sub 0.5}Fe{sub 0.5}Se{sub 2} and faster electron

  10. Wnt signaling pathway involvement in genotypic and phenotypic variations in Waardenburg syndrome type 2 with MITF mutations.

    Science.gov (United States)

    Wang, Xue-Ping; Liu, Ya-Lan; Mei, Ling-Yun; He, Chu-Feng; Niu, Zhi-Jie; Sun, Jie; Zhao, Yu-Lin; Feng, Yong; Zhang, Hua

    2018-05-01

    Mutation in the gene encoding microphthalmia-associated transcription factor (MITF) lead to Waardenburg syndrome 2 (WS2), an autosomal dominantly inherited syndrome with auditory-pigmentary abnormalities, which is clinically and genetically heterogeneous. Haploinsufficiency may be the underlying mechanism for WS2. However, the mechanisms explaining the genotypic and phenotypic variations in WS2 caused by MITF mutations are unclear. A previous study revealed that MITF interacts with LEF-1, an important factor in the Wnt signaling pathway, to regulate its own transcription through LEF-1-binding sites on the MITF promoter. In this study, four different WS2-associated MITF mutations (p.R217I, p.R217G, p.R255X, p.R217del) that are associated with highly variable clinical features were chosen. According to the results, LEF-1 can activate the expression of MITF on its own, but MITF proteins inhibited the activation. This inhibition weakens when the dosage of MITF is reduced. Except for p.R217I, p.R255X, p.R217G, and p.R217del lose the ability to activate TYR completely and do not inhibit the LEF-1-mediated activation of the MITF-M promoter, and the haploinsufficiency created by mutant MITF can be overcome; correspondingly, the mutants' associated phenotypes are less severe than that of p.R217I. The dominant negative of p.R217del made it have a second-most severe phenotype. This study's data imply that MITF has a negative feedback loop of regulation to stabilize MITF gene dosage that involves the Wnt signaling pathway and that the interaction of MITF mutants with this pathway drives the genotypic and phenotypic differences observed in Waardenburg syndrome type 2 associated with MITF mutations.

  11. Vascular relaxation induced by C-type natriuretic peptide involves the ca2+/NO-synthase/NO pathway.

    Directory of Open Access Journals (Sweden)

    Fernanda A Andrade

    Full Text Available AIMS: C-type natriuretic peptide (CNP and nitric oxide (NO are endothelium-derived factors that play important roles in the regulation of vascular tone and arterial blood pressure. We hypothesized that NO produced by the endothelial NO-synthase (NOS-3 contributes to the relaxation induced by CNP in isolated rat aorta via activation of endothelial NPR-C receptor. Therefore, the aim of this study was to investigate the putative contribution of NO through NPR-C activation in the CNP induced relaxation in isolated conductance artery. MAIN METHODS: Concentration-effect curves for CNP were constructed in aortic rings isolated from rats. Confocal microscopy was used to analyze the cytosolic calcium mobilization induced by CNP. The phosphorylation of the residue Ser1177 of NOS was analyzed by Western blot and the expression and localization of NPR-C receptors was analyzed by immunohistochemistry. KEY FINDINGS: CNP was less potent in inducing relaxation in denuded endothelium aortic rings than in intact ones. L-NAME attenuated the potency of CNP and similar results were obtained in the presence of hydroxocobalamin, an intracellular NO0 scavenger. CNP did not change the phosphorylation of Ser1177, the activation site of NOS-3, when compared with control. The addition of CNP produced an increase in [Ca2+]c in endothelial cells and a decrease in [Ca2+]c in vascular smooth muscle cells. The NPR-C-receptors are expressed in endothelial and adventitial rat aortas. SIGNIFICANCE: These results suggest that CNP-induced relaxation in intact aorta isolated from rats involves NO production due to [Ca2+]c increase in endothelial cells possibly through NPR-C activation expressed in these cells. The present study provides a breakthrough in the understanding of the close relationship between the vascular actions of nitric oxide and CNP.

  12. A divergent [5+2] cascade approach to bicyclo[3.2.1]octanes: facile synthesis of ent-kaurene and cedrene-type skeletons.

    Science.gov (United States)

    He, Chi; Bai, Zengbing; Hu, Jialei; Wang, Bingnan; Xie, Hujun; Yu, Lei; Ding, Hanfeng

    2017-07-25

    A solvent-dependent oxidative dearomatization-induced divergent [5+2] cascade approach to bicyclo[3.2.1]octanes was described. This novel protocol enables a facile synthesis of a series of diversely functionalized ent-kaurene and cedrene-type skeletons in good yields and excellent diastereoselectivities.

  13. An Analysis of Cultural Diversity and Recurring Themes in Preservice Teachers' Online Discussions of Epstein's Six Types of Parent Involvement

    Science.gov (United States)

    Nathans, Laura; Revelle, Carol

    2013-01-01

    This study used a qualitative, grounded theoretical framework to examine integration of Joyce Epstein's six typologies of family involvement in responses to discussion questions for an online parent involvement course. Fifty-two undergraduate students' responses were axially coded. Overarching themes were then determined with the constant…

  14. Pore pressure measurement plan of near field rock used on three dimensional groundwater flow analysis in demonstration test of cavern type disposal facility

    International Nuclear Information System (INIS)

    Onuma, Kazuhiro; Terada, Kenji; Matsumura, Katsuhide; Koyama, Toshihiro; Yajima, Kazuaki

    2008-01-01

    Demonstration test of underground cavern type disposal facilities is planed though carrying out construction of full scale engineering barrier system which simulated in the underground space in full scale and under actual environment. This test consists of three part, these are construction test, performance test and measurement test. Behavior of near field rock mass is measured about hydrological behavior under and after construction to evaluate effect at test facility. To make plan of pore pressure measurement, three dimensional groundwater flow analysis has been carried out. Based on comparison of analysis before and after test, detail plan has been studied. (author)

  15. The Breda Study: Search for genetic factors involved in type 2 diabetes mellitus in a defined Dutch population

    NARCIS (Netherlands)

    Tilburg, Jonathan Hendrik Otto van

    2002-01-01

    Little is known about the nature of genetic variation underlying complex diseases in humans. The recognition that susceptibility to type 2 diabetes mellitus has a strong inherited component provides a mechanism for developing the molecular understanding of the pathogenesis of type 2 diabetes

  16. Optimal Embeddings of Bessel-Potential-Type Spaces into Generalized Hölder Spaces Involving k-Modulus of Smoothness

    Czech Academy of Sciences Publication Activity Database

    Gogatishvili, Amiran; Neves, J. S.; Opic, Bohumír

    2010-01-01

    Roč. 32, č. 3 (2010), s. 201-228 ISSN 0926-2601 R&D Projects: GA ČR GA201/05/2033; GA ČR GA201/08/0383 Institutional research plan: CEZ:AV0Z10190503 Keywords : slowly varying functions * Lorentz-Karamata spaces * Rearrangement-invariant Banach function spaces * Bessel potentials * (fractional) Sobolev-type spaces * Hölder-type spaces * Zygmund-type spaces Subject RIV: BA - General Mathematics Impact factor: 0.853, year: 2010 http://link.springer.com/article/10.1007%2Fs11118-009-9148-2

  17. Micro solid-phase radioimmunoassay for detection of herpesvirus type-specific antibody: parameters involved in standardization

    Energy Technology Data Exchange (ETDEWEB)

    Matson, D.O.; Adler-Storthz, K.; Adam, E.; Dreesman, G.R. (Baylor Univ., Houston, TX (USA). Coll. of Medicine)

    1983-02-01

    A micro solid-phase radioimmunoassay (micro-SPRIA) was developed to demonstrate type-specific antibodies to herpes simplex virus types 1 and 2 (HSV1 and HSV2). Glycoproteins from the 123,000 dalton region of HSV1 (VP123) and the 119,000 dalton region of HSV2 (VP119) were isolated on preparative polyacrylamide gels for use as antigens in the micro-SPRIA. Human sera selected from clinical samples by virological history and appropriate microneutralization data were used to standardize the micro-SPRIA. Optimization of the assay required the use of siliconized microtiter wells for adsorption of antigen. Maximized results were highly dependent on the concentrations of antigen, primary antibody, and secondary antibody as well as the diluents used for these principal test reagents. Incorporation of HSV glycoproteins of each respective type with the optimal condition established in this study facilitates the direct detection of type-specific antibody in human sera.

  18. Study protocol for the SMART2D adaptive implementation trial: a cluster randomised trial comparing facility-only care with integrated facility and community care to improve type 2 diabetes outcomes in Uganda, South Africa and Sweden.

    Science.gov (United States)

    Guwatudde, David; Absetz, Pilvikki; Delobelle, Peter; Östenson, Claes-Göran; Olmen Van, Josefien; Alvesson, Helle Molsted; Mayega, Roy William; Ekirapa Kiracho, Elizabeth; Kiguli, Juliet; Sundberg, Carl Johan; Sanders, David; Tomson, Göran; Puoane, Thandi; Peterson, Stefan; Daivadanam, Meena

    2018-03-17

    Type 2 diabetes (T2D) is increasingly contributing to the global burden of disease. Health systems in most parts of the world are struggling to diagnose and manage T2D, especially in low-income and middle-income countries, and among disadvantaged populations in high-income countries. The aim of this study is to determine the added benefit of community interventions onto health facility interventions, towards glycaemic control among persons with diabetes, and towards reduction in plasma glucose among persons with prediabetes. An adaptive implementation cluster randomised trial is being implemented in two rural districts in Uganda with three clusters per study arm, in an urban township in South Africa with one cluster per study arm, and in socially disadvantaged suburbs in Stockholm, Sweden with one cluster per study arm. Clusters are communities within the catchment areas of participating primary healthcare facilities. There are two study arms comprising a facility plus community interventions arm and a facility-only interventions arm. Uganda has a third arm comprising usual care. Intervention strategies focus on organisation of care, linkage between health facility and the community, and strengthening patient role in self-management, community mobilisation and a supportive environment. Among T2D participants, the primary outcome is controlled plasma glucose; whereas among prediabetes participants the primary outcome is reduction in plasma glucose. The study has received approval in Uganda from the Higher Degrees, Research and Ethics Committee of Makerere University School of Public Health and from the Uganda National Council for Science and Technology; in South Africa from the Biomedical Science Research Ethics Committee of the University of the Western Cape; and in Sweden from the Regional Ethical Board in Stockholm. Findings will be disseminated through peer-reviewed publications and scientific meetings. ISRCTN11913581; Pre-results. © Article author(s) (or their

  19. Access to the decision-making process: opportunities for public involvement in the facility decommissioning process of the United States Nuclear Regulatory Commission

    International Nuclear Information System (INIS)

    Cameron, F.X.

    1996-01-01

    This paper discusses recent initiatives taken by the United States Nuclear Regulatory Commission NRC) to effectively involve the public in decommissioning decisions. Initiatives discussed include the Commission's rulemaking to establish the radiological criteria for decommissioning, as well as public involvement methods that have been used on a site-by-site basis. As un example of public involvement, the NRC is currently in the process of developing generic rules on the radiological criteria for the decontamination and decommissioning of NRC-licensed sites. Not only was this proposed rule developed through an extensive and novel approach for public involvement, but it also establishes the basic provisions that will govern public involvement in future NRC decisions on the decommissioning of individual sites. The aim is to provide the public with timely information about all phases of the NRC staff to express concerns and make recommendations. Th NRC recognizes the value and the necessity of effective public involvement in its regulatory activities and has initiated a number of changes to its regulatory program to accomplish this. From the NRC's perspective, it is much easier and less costly to incorporate these mechanisms for public involvement into the regulatory program early in the process, rather than try to add them after considerable public controversy on an action has already been generated. The historical antecedents for initiatives mentioned, as well as 'lessons learned' from prior experience are also discussed. (author)

  20. Resolution of type 2 diabetes following gastric bypass surgery: involvement of gut-derived glucagon and glucagonotropic signalling?

    DEFF Research Database (Denmark)

    Knop, Filip Krag

    2009-01-01

    Certain types of bariatric surgical procedures have proved not only to be effective with regard to treating obesity, but they also seem to be associated with endocrine changes which independently of weight loss give rise to remission of type 2 diabetes. Currently, it is speculated that surgical re......-derived glucagonotropic signalling as putative diabetogenic signals of the foregut hypothesis. In the present paper the hypotheses describing the glucose-lowering mechanisms of bariatric surgical procedures sharing the common feature of a bypass of the duodenum and the proximal jejunum are outlined and a possible role...

  1. The Explicit Identities for Spectral Norms of Circulant-Type Matrices Involving Binomial Coefficients and Harmonic Numbers

    Directory of Open Access Journals (Sweden)

    Jianwei Zhou

    2014-01-01

    Full Text Available The explicit formulae of spectral norms for circulant-type matrices are investigated; the matrices are circulant matrix, skew-circulant matrix, and g-circulant matrix, respectively. The entries are products of binomial coefficients with harmonic numbers. Explicit identities for these spectral norms are obtained. Employing these approaches, some numerical tests are listed to verify the results.

  2. A low absolute number of expanded transcripts is involved in myotonic dystrophy type 1 manifestation in muscle

    NARCIS (Netherlands)

    Gudde, A.E.; Gonzalez-Barriga, A.; Broek, W.J. van den; Wieringa, B.; Wansink, D.G.

    2016-01-01

    Muscular manifestation of myotonic dystrophy type 1 (DM1), a common inheritable degenerative multisystem disorder, is mainly caused by expression of RNA from a (CTG.CAG)n-expanded DM1 locus. Here, we report on comparative profiling of expression of normal and expanded endogenous or transgenic

  3. Comparison of model Hartree-Fock type calculation schemes involving various non-degenerate and quasi-degenerate intrinsic Hamiltonians

    International Nuclear Information System (INIS)

    Amusa, A.

    1983-03-01

    Different Hamiltonians and their corresponding rotationally degenerate intrinsic counterparts are employed in the study of 18 O nucleus under the normal Hartree-Fock, as well as under six other Hartree-Fock type variational calculation schemes. The results are compared and then assessed in the light of their closeness or otherwise to the full 1s-0d basis shell model calculations for this nucleus. The use of these schemes for other shells is also considered. (author)

  4. [Morphological alterations in nailfold capillaroscopy and the clinical picture of vascular involvement in autoimmune diseases: systemic lupus erythematosus and type 1 diabetes].

    Science.gov (United States)

    Kuryliszyn-Moskal, Anna; Ciołkiewicz, Mariusz; Dubicki, Artur

    2010-01-01

    Systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (DM) belong to the group of autoimmune diseases presenting with a wide range of organ manifestations. Microvascular abnormalities seem to play a crucial role in the development of persistent multi-organ complications in both diseases. The aim of this study was to determine the relationship between microvascular changes examined with nailfold capillaroscopy and organ involvement. We eurolled 76 SLE patients, 106 patients with type 1 diabetes, and 40 healthy controls. Morphological changes were observed with nailfold capillaroscopy in 86 (81%) diabetics and in 70 (92.1%) SLE patients. Severe capillaroscopic changes were disclosed in 32 out of 54 (59%) diabetic patients with microangiopathy and in only 7 out of 52 (13%) patients without microangiopathy. In the SLE group, severe capillaroscopic abnormalities were found in 18 out of 34 (52.9%) patients with organ involvement and in 9 out of 42 (21.4%) patients without organ involvement. The capillaroscopic score was significantly higher in diabetic patients with microangiopathic complications in comparison to patients without microangiopathy (p nailfold capillaroscopy reflect the extent of microvascular involvement and are associated with organ involvement in SLE and diabetes.

  5. Bone marrow involvement in diffuse large B-cell lymphoma: correlation between FDG-PET uptake and type of cellular infiltrate

    International Nuclear Information System (INIS)

    Paone, Gaetano; Itti, Emmanuel; Lin, Chieh; Meignan, Michel; Haioun, Corinne; Dupuis, Jehan; Gaulard, Philippe

    2009-01-01

    To assess, in patients with diffuse large B-cell lymphoma (DLBCL), whether the low sensitivity of 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) for bone marrow assessment may be explained by histological characteristics of the cellular infiltrate. From a prospective cohort of 110 patients with newly diagnosed aggressive lymphoma, 21 patients with DLBCL had bone marrow involvement. Pretherapeutic FDG-PET images were interpreted visually and semiquantitatively, then correlated with the type of cellular infiltrate and known prognostic factors. Of these 21 patients, 7 (33%) had lymphoid infiltrates with a prominent component of large transformed lymphoid cells (concordant bone marrow involvement, CBMI) and 14 (67%) had lymphoid infiltrates composed of small cells (discordant bone marrow involvement, DBMI). Only 10 patients (48%) had abnormal bone marrow FDG uptake, 6 of the 7 with CBMI and 4 of the 14 with DBMI. Therefore, FDG-PET positivity in the bone marrow was significantly associated with CBMI, while FDG-PET negativity was associated with DBMI (Fisher's exact test, p=0.024). There were no significant differences in gender, age and overall survival between patients with CBMI and DBMI, while the international prognostic index was significantly higher in patients with CBMI. Our study suggests that in patients with DLBCL with bone marrow involvement bone marrow FDG uptake depends on two types of infiltrate, comprising small (DBMI) or large (CBMI) cells. This may explain the apparent low sensitivity of FDG-PET previously reported for detecting bone marrow involvement. (orig.)

  6. Guide to research facilities

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This Guide provides information on facilities at US Department of Energy (DOE) and other government laboratories that focus on research and development of energy efficiency and renewable energy technologies. These laboratories have opened these facilities to outside users within the scientific community to encourage cooperation between the laboratories and the private sector. The Guide features two types of facilities: designated user facilities and other research facilities. Designated user facilities are one-of-a-kind DOE facilities that are staffed by personnel with unparalleled expertise and that contain sophisticated equipment. Other research facilities are facilities at DOE and other government laboratories that provide sophisticated equipment, testing areas, or processes that may not be available at private facilities. Each facility listing includes the name and phone number of someone you can call for more information.

  7. Multimodal Stepped Care Approach Involving Topical Analgesics for Severe Intractable Neuropathic Pain in CRPS Type 1: A Case Report

    Directory of Open Access Journals (Sweden)

    David J. Kopsky

    2011-01-01

    Full Text Available A multimodal stepped care approach has been successfully applied to a patient with complex regional pain syndrome type 1 and severe intractable pain, not responding to regular neuropathic pain medication. The choice to administer drugs in creams was made because of the intolerable adverse effects to oral medication. With this method, peak-dose adverse effects did not occur. The multimodal stepped care approach resulted in considerable and clinically relevant decrease in pain after every step, using topical amitriptyline, ketamine, and dimethylsulphoxide.

  8. Facile fabrication of wire-type indium gallium zinc oxide thin-film transistors applicable to ultrasensitive flexible sensors.

    Science.gov (United States)

    Kim, Yeong-Gyu; Tak, Young Jun; Kim, Hee Jun; Kim, Won-Gi; Yoo, Hyukjoon; Kim, Hyun Jae

    2018-04-03

    We fabricated wire-type indium gallium zinc oxide (IGZO) thin-film transistors (TFTs) using a self-formed cracked template based on a lift-off process. The electrical characteristics of wire-type IGZO TFTs could be controlled by changing the width and density of IGZO wires through varying the coating conditions of template solution or multi-stacking additional layers. The fabricated wire-type devices were applied to sensors after functionalizing the surface. The wire-type pH sensor showed a sensitivity of 45.4 mV/pH, and this value was an improved sensitivity compared with that of the film-type device (27.6 mV/pH). Similarly, when the wire-type device was used as a glucose sensor, it showed more variation in electrical characteristics than the film-type device. The improved sensing properties resulted from the large surface area of the wire-type device compared with that of the film-type device. In addition, we fabricated wire-type IGZO TFTs on flexible substrates and confirmed that such structures were very resistant to mechanical stresses at a bending radius of 10 mm.

  9. Case report of unexpected gastrointestinal involvement in type 1 Gaucher disease: comparison of eliglustat tartrate treatment and enzyme replacement therapy.

    Science.gov (United States)

    Kim, Yoo-Mi; Shin, Dong Hoon; Park, Su Bum; Cheon, Chong Kun; Yoo, Han-Wook

    2017-05-15

    Gastrointestinal involvement in Gaucher disease is very rare, and appears to be unresponsive to enzyme replacement therapy (ERT). Here, we describe identical twin, splenectomized, non-neuronopathic Gaucher patients on long-term ERT for 9 years, who complained of epigastric discomfort due to Gaucher cell infiltration of the gastroduodenal mucosa. Rare compound heterozygous mutations (p.Arg48Trp and p.Arg257Gln) of the GBA gene were found in both. Improvement in the gastroduodenal infiltration and reduced chitotriosidase levels were observed in one who switched to eliglustat tartrate for 1 year, whereas the other one who maintained ERT showed no improvement of chitotriosidase level and persistent duodenal lesions. This shows that eliglustat might be an effective treatment for Gaucher disease patients having lesions resistant to ERT.

  10. Diffuse reticuloendothelial system involvement in type IV glycogen storage disease with a novel GBE1 mutation: a case report and review.

    Science.gov (United States)

    Magoulas, Pilar L; El-Hattab, Ayman W; Roy, Angshumoy; Bali, Deeksha S; Finegold, Milton J; Craigen, William J

    2012-06-01

    Glycogen storage disease type IV is a rare autosomal recessive disorder of glycogen metabolism caused by mutations in the GBE1 gene that encodes the 1,4-alpha-glucan-branching enzyme 1. Its clinical presentation is variable, with the most common form presenting in early childhood with primary hepatic involvement. Histologic manifestations in glycogen storage disease type IV typically consist of intracytoplasmic non-membrane-bound inclusions containing abnormally branched glycogen (polyglucosan bodies) within hepatocytes and myocytes. We report a female infant with classic hepatic form of glycogen storage disease type IV who demonstrated diffuse reticuloendothelial system involvement with the spleen, bone marrow, and lymph nodes infiltrated by foamy histiocytes with intracytoplasmic polyglucosan deposits. Sequence analysis of the GBE1 gene revealed compound heterozygosity for a previously described frameshift mutation (c.1239delT) and a novel missense mutation (c.1279G>A) that is predicted to alter a conserved glycine residue. GBE enzyme analysis revealed no detectable activity. A review of the literature for glycogen storage disease type IV patients with characterized molecular defects and deficient enzyme activity reveals most GBE1 mutations to be missense mutations clustering in the catalytic enzyme domain. Individuals with the classic hepatic form of glycogen storage disease type IV tend to be compound heterozygotes for null and missense mutations. Although the extensive reticuloendothelial system involvement that was observed in our patient is not typical of glycogen storage disease type IV, it may be associated with severe enzymatic deficiency and a poor outcome. Copyright © 2012 Elsevier Inc. All rights reserved.

  11. Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro

    Energy Technology Data Exchange (ETDEWEB)

    Pei, Ying, E-mail: peiying-19802@163.com [Biomedicine Research and Development Center of Jinan University, Guangzhou, Guangdong 510632 (China); Chen, Zhen-Ping, E-mail: 530670663@qq.com [Biomedicine Research and Development Center of Jinan University, Guangzhou, Guangdong 510632 (China); Ju, Huai-Qiang, E-mail: 344464448@qq.com [Biomedicine Research and Development Center of Jinan University, Guangzhou, Guangdong 510632 (China); Komatsu, Masaaki, E-mail: komatsu-ms@igakuken.or.jp [Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku, Tokyo 113-8613 (Japan); Ji, Yu-hua, E-mail: tjyh@jnu.edu.cn [Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou 510632 (China); Liu, Ge, E-mail: lggege_15@hotmail.com [Division of Molecular Pharmacology of Infectious agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521 (Japan); Guo, Chao-wan, E-mail: chaovan_kwok@hotmail.com [Division of Molecular Pharmacology of Infectious agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521 (Japan); Zhang, Ying-Jun, E-mail: zhangyj@mail.kib.ac.cn [Kunming Institute of Botany, the Chinese Academy of Sciences, Yunnan, Kunming 650204 (China); Yang, Chong-Ren, E-mail: cryang@mail.kib.ac.cn [Kunming Institute of Botany, the Chinese Academy of Sciences, Yunnan, Kunming 650204 (China); Wang, Yi-Fei, E-mail: twang-yf@163.com [Biomedicine Research and Development Center of Jinan University, Guangzhou, Guangdong 510632 (China); Kitazato, Kaio, E-mail: kkholi@msn.com [Division of Molecular Pharmacology of Infectious agents, Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8521 (Japan)

    2011-02-11

    Research highlights: {yields} We showed PGG has anti-viral activity against Herpes simplex virus type 1 (HSV-1) and can induce autophgy. {yields} Autophagy may be a novel and important mechanism mediating PGG anti-viral activities. {yields} Inhibition of mTOR pathway is an important mechanism of induction of autophagy by PGG. -- Abstract: Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7{sup -/-} cells (autophagy-defective cells) derived from an atg7{sup -/-} knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro.

  12. Autophagy is involved in anti-viral activity of pentagalloylglucose (PGG) against Herpes simplex virus type 1 infection in vitro

    International Nuclear Information System (INIS)

    Pei, Ying; Chen, Zhen-Ping; Ju, Huai-Qiang; Komatsu, Masaaki; Ji, Yu-hua; Liu, Ge; Guo, Chao-wan; Zhang, Ying-Jun; Yang, Chong-Ren; Wang, Yi-Fei; Kitazato, Kaio

    2011-01-01

    Research highlights: → We showed PGG has anti-viral activity against Herpes simplex virus type 1 (HSV-1) and can induce autophgy. → Autophagy may be a novel and important mechanism mediating PGG anti-viral activities. → Inhibition of mTOR pathway is an important mechanism of induction of autophagy by PGG. -- Abstract: Pentagalloylglucose (PGG) is a natural polyphenolic compound with broad-spectrum anti-viral activity, however, the mechanisms underlying anti-viral activity remain undefined. In this study, we investigated the effects of PGG on anti-viral activity against Herpes simplex virus type 1 (HSV-1) associated with autophagy. We found that the PGG anti-HSV-1 activity was impaired significantly in MEF-atg7 -/- cells (autophagy-defective cells) derived from an atg7 -/- knockout mouse. Transmission electron microscopy revealed that PGG-induced autophagosomes engulfed HSV-1 virions. The mTOR signaling pathway, an essential pathway for the regulation of autophagy, was found to be suppressed following PGG treatment. Data presented in this report demonstrated for the first time that autophagy induced following PGG treatment contributed to its anti-HSV activity in vitro.

  13. Duplications involving a conserved regulatory element downstream of BMP2 are associated with brachydactyly type A2

    DEFF Research Database (Denmark)

    Dathe, Katarina; Kjaer, Klaus W; Brehm, Anja

    2009-01-01

    Autosomal-dominant brachydactyly type A2 (BDA2), a limb malformation characterized by hypoplastic middle phalanges of the second and fifth fingers, has been shown to be due to mutations in the Bone morphogenetic protein receptor 1B (BMPR1B) or in its ligand Growth and differentiation factor 5 (GDF5......). A linkage analysis performed in a mutation-negative family identified a novel locus for BDA2 on chromosome 20p12.3 that incorporates the gene for Bone morphogenetic protein 2 (BMP2). No point mutation was identified in BMP2, so a high-density array CGH analysis covering the critical interval...... within the identified duplication. Our results reveal an additional functional mechanism for the pathogenesis of BDA2, which is duplication of a regulatory element that affects the expression of BMP2 in the developing limb....

  14. Clinical characteristics of non-obese children with type 2 diabetes mellitus without involvement of β-cell autoimmunity.

    Science.gov (United States)

    Urakami, Tatsuhiko; Kuwabara, Remi; Habu, Masako; Okuno, Misako; Suzuki, Junichi; Takahashi, Shori; Mugishima, Hideo

    2013-02-01

    We examined the clinical characteristics of non-obese Japanese children with type 2 diabetes mellitus (T2DM) not associated with β-cell autoimmunity. Of 218 children who were diagnosed as having T2DM by a school urine glucose screening program in Tokyo, 24 were identified as being non-obese and were enrolled in this study. None of the children had any evidence of β-cell autoimmunity or genetic disorders. The mean ages at diagnosis and at the study were 12.5 ± 1.7 and 22.4 ± 5.7 years, respectively. Females were predominant (M/F ratio: 4/20). Family history of T2DM, mostly of the non-obese type, was present in 62.5% of the cases. In regard to the birth weight, 20.8% had a history of low birth weight, and 8.3% were large for gestational age. The mean fasting insulin level, HOMA-R, HOMA-β, and an insulinogenic index on the OGTT at the time of diagnosis were 11.8 ± 7.8 μU/ml, 5.4 ± 3.8, 96.1 ± 55.0 and 0.16 ± 0.14, respectively. Most patients were treated by either oral hypoglycemic drug (45.8%) or insulin (50.0%) therapy at the study, with the mean interval to the start of pharmacological treatment of 3.1 ± 2.3 years. Non-obese children with T2DM seemed to show lower insulin secretory capacities with mild, but evident, insulin resistance even from the time of diagnosis, and also earlier requirement of pharmacological therapies during the clinical course. Some genetic factors not associated with autoimmunity may play a role in the etiology of T2DM in non-obese children. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  15. Involvement of spinal glutamate transporter-1 in the development of mechanical allodynia and hyperalgesia associated with type 2 diabetes

    Directory of Open Access Journals (Sweden)

    Shi J

    2016-11-01

    Full Text Available Jinshan Shi,1,* Ke Jiang,2,* Zhaoduan Li,3 1Department of Anesthesiology, Guizhou Provincial People’s Hospital, 2Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, 3Department of Anesthesiology, Tianjin Nankai Hospital, Tianjin, People’s Republic of China *These authors contributed equally to this work Abstract: Little is known about the effects of the development of type 2 diabetes on glutamate homeostasis in the spinal cord. Therefore, we quantified the extracellular levels of glutamate in the spinal cord of Zucker diabetic fatty (ZDF rats using in vivo microdialysis. In addition, protein levels of glutamate transporter-1 (GLT-1 in the spinal cord of ZDF rats were measured using Western blot. Finally, the effects of repeated intrathecal injections of ceftriaxone, which was previously shown to enhance GLT-1 expression, on the development of mechanical allodynia and hyperalgesia as well as on basal extracellular level of glutamate and the expression of GLT-1 in the spinal cord of ZDF rats were evaluated. It was found that ZDF rats developed mechanical hyperalgesia and allodynia, which were associated with increased basal extracellular levels of glutamate and attenuated levels of GLT-1 expression in the spinal cord, particularly in the dorsal horn. Furthermore, repeated intrathecal administrations of ceftriaxone dose-dependently prevented the development of mechanical hyperalgesia and allodynia in ZDF rats, which were correlated with enhanced GLT-1 expression without altering the basal glutamate levels in the spinal cord of ZDF rats. Overall, the results suggested that impaired glutamate reuptake in the spinal cord may contribute to the development of neuropathic pains in type 2 diabetes. Keywords: diabetes, peripheral neuropathy, spinal cord, Zucker diabetic fatty rats, glutamate, glutamate transporter-1

  16. A plant EPF-type zinc-finger protein, CaPIF1, involved in defence against pathogens.

    Science.gov (United States)

    Oh, Sang-Keun; Park, Jeong Mee; Joung, Young Hee; Lee, Sanghyeob; Chung, Eunsook; Kim, Soo-Yong; Yu, Seung Hun; Choi, Doil

    2005-05-01

    SUMMARY To understand better the defence responses of plants to pathogen attack, we challenged hot pepper plants with bacterial pathogens and identified transcription factor-encoding genes whose expression patterns were altered during the subsequent hypersensitive response. One of these genes, CaPIF1 (Capsicum annuum Pathogen-Induced Factor 1), was characterized further. This gene encodes a plant-specific EPF-type protein that contains two Cys(2)/His(2) zinc fingers. CaPIF1 expression was rapidly and specifically induced when pepper plants were challenged with bacterial pathogens to which they are resistant. In contrast, challenge with a pathogen to which the plants are susceptible only generated weak CaPIF1 expression. CaPIF1 expression was also strongly induced in pepper leaves by the exogenous application of ethephon, an ethylene-releasing compound, and salicylic acid, whereas methyl jasmonate had only moderate effects. CaPIF1 localized to the nuclei of onion epidermis when expressed as a CaPIF1-smGFP fusion protein. Transgenic tobacco plants over-expressing CaPIF1 driven by the CaMV 35S promoter showed increased resistance to challenge with a tobacco-specific pathogen or non-host bacterial pathogens. These plants also showed constitutive up-regulation of multiple defence-related genes. Moreover, virus-induced silencing of the CaPIF1 orthologue in Nicotiana benthamiana enhanced susceptibility to the same host or non-host bacterial pathogens. These observations provide evidence that an EPF-type Cys(2)/His(2) zinc-finger protein plays a crucial role in the activation of the pathogen defence response in plants.

  17. Time-frequency analysis to a particular type of scattering problems involving metallic-polymer tubing structures.

    Science.gov (United States)

    Elhanaoui, Abdelkader; Aassif, Elhoucein; Maze, Gérard; Décultot, Dominique

    2018-01-01

    In this paper, recent studies of backscattered acoustic signals in thinner steel-polymer tubing structures have been presented. Reassigned smoothed pseudo Wigner-Ville (rspWV) analysis has been adopted in order to diminish the cross-term effect, and achieve high resolution spectral. Vibration modes, which are associated to the resonances of circumferential waves, have been determined by using the modal isolation plan representation. At normalized frequencies below 140, an appreciable influence from the polymer coating thickness on the A 0 + and S 0 modes has been noticed. Furthermore, the trajectory of the A 0 - wave has been modified in the normalized frequency band 40-42. Group velocity curves of the A 0 - wave have, then, been graphically illustrated. The findings have shown a particular curvature change at reduced frequency 41 in the case of an immersed two-layer tube in water. Studies of acoustic backscattering involving steel-polymer tubing structures have confirmed the significant coupling of A 0 + and S 0 waves. Besides, the disappearance of the A 0 + resonance trajectory has been observed; which is a very important phenomenon to understand. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Avoidant coping moderates the relationship between paternal involvement in the child's type 1 diabetes (T1D) care and parenting stress.

    Science.gov (United States)

    Teasdale, Ashley; Limbers, Christine

    2018-01-01

    Fathers may experience greater parenting stress and anxiety when they are more involved in their child's type 1 diabetes (T1D) care. The present study evaluated whether seeking social support and avoidant coping strategies moderate the relationship between paternal involvement in the child's T1D care and parenting stress in an international sample. Two hundred forty-nine fathers of young children with T1D completed the Parenting Stress Index (PSI), Pediatric Inventory for Parents (PIP), Dads' Active Disease Support scale (DADS), COPE Inventory, Self-Care Inventory (SCI-R), and a demographic questionnaire online. Pearson's product moment correlations were computed, and multiple linear regression analysis was conducted with three separate models in which the PSI Child Domain, PIP Frequency, and PIP Difficulty scores represented different parenting stress outcomes. The interaction between use of denial coping and DADS Involvement was significantly correlated with general parenting stress ( p diabetes treatment regimen ( p management.

  19. A new AMS facility based on a Cockcroft-Walton type 1 MV tandetron at IFIN-HH Magurele, Romania

    Science.gov (United States)

    Stan-Sion, C.; Enachescu, M.; Ghita, D. G.; Calinescu, C. I.; Petre, A.; Mosu, D. V.; Klein, M.

    2014-01-01

    A 1 MV AMS machine was recently installed in the National Institute for Physics and Nuclear Engineering IFIN-HH, Bucharest Romania. It is the second AMS facility at IFIN-HH having the goal not only to continue but mainly to enlarge the research area of this highly sensitive analyzing method. The multi-element AMS was developed by HVEE to measure 14C, 10Be, and 26Al, and 129I. The results of an acceptance test are presented and demonstrate that this machine is capable of routine 14C age dating and of measurements of other radioisotopes in terms of accuracy and precision as well as a low background level.

  20. National Solar Thermal Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The National Solar Thermal Test Facility (NSTTF) is the only test facility in the United States of its type. This unique facility provides experimental engineering...

  1. Severe fuel damage experiments performed in the QUENCH facility with 21-rod bundles of LWR-type

    International Nuclear Information System (INIS)

    Sepold, L.; Hering, W.; Schanz, G.; Scholtyssek, W.; Steinbrueck, M.; Stuckert, J.

    2006-01-01

    The objective of the QUENCH experimental program at the Karlsruhe Research Center is to investigate core degradation and the hydrogen source term that results from quenching/flooding an uncovered core, to examine the physical/chemical behavior of overheated fuel elements under different flooding conditions, and to create a data base for model development and improvement of severe fuel damage (SFD) code systems. The large-scale 21-rod bundle experiments conducted in the QUENCH out-of-pile facility are supported by an extensive separate-effects test program, by modeling activities as well as application and improvement of SFD code systems. International cooperations exist with institutions mainly within the European Union but e.g. also with the Russian Academy of Science (IBRAE, Moscow) and the CSARP program of the USNRC. So far, eleven experiments have been performed, two of them with B 4 C absorber material. Experimental parameters were: the temperature at initiation of reflood, the degree of peroxidation, the quench medium, i.e. water or steam, and its injection rate, the influence of a B 4 C absorber rod, the effect of steam-starved conditions before quench, the influence of air oxidation before quench, and boil-off behavior of a water-filled bundle with subsequent quenching. The paper gives an overview of the QUENCH program with its organizational structure, describes the test facility and the test matrix with selected experimental results. (author)

  2. Mid-aortic syndrome with renovascular hypertension and multisystem involvement in a girl with familiar neurofibromatosis von Recklinghausen type 1.

    Science.gov (United States)

    Petrak, Borivoj; Bendova, Sarka; Seeman, Tomas; Klein, Tibor; Lisy, Jiri; Zatrapa, Tomas; Marikova, Tana

    2007-12-01

    Neurofibromatosis von Recklinghausen type 1 (NF1) is an autosomal dominant neurocutaneous disorder affecting one in 3 000-4 000 individuals. Mid-aortic syndrome (MAS) is a rare condition characterized by segmental narrowing of abdominal aorta and stenosis of its major branches - mainly renal arteries, including manifestation of renovascular hypertension. MAS can be caused by different diseases, including NF1. A 9 years old girl with primary diagnosis of NF1 combined with renovascular hypertension due to MAS, suffered of bilateral optic and chiasm glioma, pubertas praecox, speech disorder, light mental retardation and scoliosis. We have found a mutation in exone 34 of the NF1 gene (17q11.2). Her father has been also diagnosed with NF1 and hypertension developed at early age. He has the same mutation in exone 34 of NF1 gene. The girl is currently treated with conservative antihypertensive medication with positive effect. Bilateral optic and chiasm glioma are asymptomatic at the time and they had been without progress over period of time. Any vascular surgery, neurosurgical and oncological therapy are not indicated at the present time. This article is a summary of clinical findings in patient with NF1 due to NF1 gene mutation in exone 34. It confirms the importance of complex multidisciplinar approach to examination and taking care of NF1 patients and their families.

  3. Identification and characterization of bZIP-type transcription factors involved in carrot (Daucus carota L.) somatic embryogenesis.

    Science.gov (United States)

    Guan, Yucheng; Ren, Haibo; Xie, He; Ma, Zeyang; Chen, Fan

    2009-10-01

    Seed dormancy is an important adaptive trait that enables seeds of many species to remain quiescent until conditions become favorable for germination. Abscisic acid (ABA) plays an important role in these developmental processes. Like dormancy and germination, the elongation of carrot somatic embryo radicles is retarded by sucrose concentrations at or above 6%, and normal growth resumes at sucrose concentrations below 3%. Using a yeast one-hybrid screening system, we isolated two bZIP-type transcription factors, CAREB1 and CAREB2, from a cDNA library prepared from carrot somatic embryos cultured in a high-sucrose medium. Both CAREB1 and CAREB2 were localized to the nucleus, and specifically bound to the ABA response element (ABRE) in the Dc3 promoter. Expression of CAREB2 was induced in seedlings by drought and exogenous ABA application; whereas expression of CAREB1 increased during late embryogenesis, and reduced dramatically when somatic embryos were treated with fluridone, an inhibitor of ABA synthesis. Overexpression of CAREB1 caused somatic embryos to develop slowly when cultured in low-sucrose medium, and retarded the elongation of the radicles. These results indicate that CAREB1 and CAREB2 have similar DNA-binding activities, but play different roles during carrot development. Our results indicate that CAREB1 functions as an important trans-acting factor in the ABA signal transduction pathway during carrot somatic embryogenesis.

  4. Involvement of dietary saturated fats, from all sources or of dairy origin only, in insulin resistance and type 2 diabetes.

    Science.gov (United States)

    Morio, Béatrice; Fardet, Anthony; Legrand, Philippe; Lecerf, Jean-Michel

    2016-01-01

    Reducing the consumption of saturated fatty acids to a level as low as possible is a European public health recommendation to reduce the risk of cardiovascular disease. The association between dietary intake of saturated fatty acids and development and management of type 2 diabetes mellitus (T2DM), however, is a matter of debate. A literature search was performed to identify prospective studies and clinical trials in humans that explored the association between dietary intake of saturated fatty acids and risk of insulin resistance and T2DM. Furthermore, to assess whether specific foods, and not just the saturated fatty acid content of the food matrix, can have differential effects on human health, the relationship between consumption of full-fat dairy products, a main source of dietary saturated fatty acids, and risk of insulin resistance and T2DM was studied. There is no evidence that dietary saturated fatty acids from varied food sources affect the risk of insulin resistance or T2DM, nor is intake of full-fat dairy products associated with this risk. These findings strongly suggest that future studies on the effects of dietary saturated fatty acids should take into account the complexity of the food matrix. Furthermore, communication on saturated fats and their health effects should be prudent and well informed. © The Author(s) 2015. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  5. Infinitely many solutions for Schrodinger-Kirchhoff type equations involving the fractional p-Laplacian and critical exponent

    Directory of Open Access Journals (Sweden)

    Li Wang

    2016-12-01

    Full Text Available In this article, we show the existence of infinitely many solutions for the fractional p-Laplacian equations of Schrodinger-Kirchhoff type equation $$ M([u]_{s, p}^p (-\\Delta _p^s u+V(x|u|^{p-2}u= \\alpha |u|^{ p_s^{*}-2 }u+\\beta k(x|u|^{q-2}u \\quad x\\in \\mathbb{R}^N, $$ where $(-\\Delta ^s_p$ is the fractional p-Laplacian operator, $[u]_{s,p}$ is the Gagliardo p-seminorm, $0 sp$, $1

  6. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types.

    Science.gov (United States)

    Iliopoulos, Dimitrios; Hirsch, Heather A; Struhl, Kevin

    2011-05-01

    Metformin, the first-line drug for treating diabetes, selectively kills the chemotherapy resistant subpopulation of cancer stem cells (CSC) in genetically distinct types of breast cancer cell lines. In mouse xenografts, injection of metformin and the chemotherapeutic drug doxorubicin near the tumor is more effective than either drug alone in blocking tumor growth and preventing relapse. Here, we show that metformin is equally effective when given orally together with paclitaxel, carboplatin, and doxorubicin, indicating that metformin works together with a variety of standard chemotherapeutic agents. In addition, metformin has comparable effects on tumor regression and preventing relapse when combined with a four-fold reduced dose of doxorubicin that is not effective as a monotherapy. Finally, the combination of metformin and doxorubicin prevents relapse in xenografts generated with prostate and lung cancer cell lines. These observations provide further evidence for the CSC hypothesis for cancer relapse, an experimental rationale for using metformin as part of combinatorial therapy in a variety of clinical settings, and for reducing the chemotherapy dose in cancer patients.

  7. Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.

    Science.gov (United States)

    Chung, Chee Yeun; Seo, Hyemyung; Sonntag, Kai Christian; Brooks, Andrew; Lin, Ling; Isacson, Ole

    2005-07-01

    Molecular differences between dopamine (DA) neurons may explain why the mesostriatal DA neurons in the A9 region preferentially degenerate in Parkinson's disease (PD) and toxic models, whereas the adjacent A10 region mesolimbic and mesocortical DA neurons are relatively spared. To characterize innate physiological differences between A9 and A10 DA neurons, we determined gene expression profiles in these neurons in the adult mouse by laser capture microdissection, microarray analysis and real-time PCR. We found 42 genes relatively elevated in A9 DA neurons, whereas 61 genes were elevated in A10 DA neurons [> 2-fold; false discovery rate (FDR) neurotoxic or protective biochemical pathways. Three A9-elevated molecules [G-protein coupled inwardly rectifying K channel 2 (GIRK2), adenine nucleotide translocator 2 (ANT-2) and the growth factor IGF-1] and three A10-elevated peptides (GRP, CGRP and PACAP) were further examined in both alpha-synuclein overexpressing PC12 (PC12-alphaSyn) cells and rat primary ventral mesencephalic (VM) cultures exposed to MPP+ neurotoxicity. GIRK2-positive DA neurons were more vulnerable to MPP+ toxicity and overexpression of GIRK2 increased the vulnerability of PC12-alphaSyn cells to the toxin. Blocking of ANT decreased vulnerability to MPP+ in both cell culture systems. Exposing cells to IGF-1, GRP and PACAP decreased vulnerability of both cell types to MPP+, whereas CGRP protected PC12-alphaSyn cells but not primary VM DA neurons. These results indicate that certain differentially expressed molecules in A9 and A10 DA neurons may play key roles in their relative vulnerability to toxins and PD.

  8. Arabidopsis Root-Type Ferredoxin:NADP(H) Oxidoreductase 2 is Involved in Detoxification of Nitrite in Roots.

    Science.gov (United States)

    Hachiya, Takushi; Ueda, Nanae; Kitagawa, Munenori; Hanke, Guy; Suzuki, Akira; Hase, Toshiharu; Sakakibara, Hitoshi

    2016-11-01

    Ferredoxin:NADP(H) oxidoreductase (FNR) plays a key role in redox metabolism in plastids. Whereas leaf FNR (LFNR) is required for photosynthesis, root FNR (RFNR) is believed to provide electrons to ferredoxin (Fd)-dependent enzymes, including nitrite reductase (NiR) and Fd-glutamine-oxoglutarate aminotransferase (Fd-GOGAT) in non-photosynthetic conditions. In some herbal species, however, most nitrate reductase activity is located in photosynthetic organs, and ammonium in roots is assimilated mainly by Fd-independent NADH-GOGAT. Therefore, RFNR might have a limited impact on N assimilation in roots grown with nitrate or ammonium nitrogen sources. AtRFNR genes are rapidly induced by application of toxic nitrite. Thus, we tested the hypothesis that RFNR could contribute to nitrite reduction in roots by comparing Arabidopsis thaliana seedlings of the wild type with loss-of-function mutants of RFNR2 When these seedlings were grown under nitrate, nitrite or ammonium, only nitrite nutrition caused impaired growth and nitrite accumulation in roots of rfnr2 Supplementation of nitrite with nitrate or ammonium as N sources did not restore the root growth in rfnr2 Also, a scavenger for nitric oxide (NO) could not effectively rescue the growth impairment. Thus, nitrite toxicity, rather than N depletion or nitrite-dependent NO production, probably causes the rfnr2 root growth defect. Our results strongly suggest that RFNR2 has a major role in reduction of toxic nitrite in roots. A specific set of genes related to nitrite reduction and the supply of reducing power responded to nitrite concomitantly, suggesting that the products of these genes act co-operatively with RFNR2 to reduce nitrite in roots. © The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  9. An autopsied case of MV2K + C-type sporadic Creutzfeldt-Jakob disease presenting with widespread cerebral cortical involvement and Kuru plaques.

    Science.gov (United States)

    Iwasaki, Yasushi; Saito, Yufuko; Aiba, Ikuko; Kobayashi, Atsushi; Mimuro, Maya; Kitamoto, Tetsuyuki; Yoshida, Mari

    2017-06-01

    MV2-type sporadic Creutzfeldt-Jakob disease (sCJD), which was previously called "Kuru-plaque variant", was gradually revealed to have a wide spectrum and has been classified into three pathological subtypes: MV2K, MV2C and MV2K + C. We herein describe the detailed clinical findings and neuropathologic observations from an autopsied MV2K + C-type Japanese sCJD case with widespread cerebral cortical pathology and Kuru plaques. In the early stages of the disease, the patient exhibited gait disturbance with ataxia and dysarthria as well as gradual appearance of cognitive dysfunction. Diffusion-weighted images (DWI) on MRI revealed extensive cerebral cortical hyperintensity. Pathologic investigation revealed extensive spongiform change in the cerebral cortex, particularly in the deeper layers. Vacuole size varied, and some were confluent. Prion protein (PrP) immunostaining revealed extensive PrP deposition in the cerebral cortex, basal ganglia, thalamus, cerebellum, brainstem and spinal cord. In the cerebral cortex, synaptic-type, Kuru plaque-like, and coarse plaque-type PrP depositions were mainly observed, along with some perivacuolar-type PrP depositions. Kuru plaques and coarse plaque-type PrP depositions also were observed in the cerebellar cortex. PrP gene analysis revealed no mutations, and polymorphic codon 129 exhibited Met/Val heterozygosity. Western blot analysis revealed a mixture of intermediate-type PrP Sc and type 2 PrP Sc . Based on previous reports regarding MV2-type sCJD and the clinicopathologic findings of the present case, we speculated that it may be possible to clinically distinguish each MV2 subtype. Clinical presentation of the MV2K + C subtype includes predominant cerebral cortical involvement signs with ataxia and DWI hyperintensity of the cerebral cortex on MRI. © 2016 Japanese Society of Neuropathology.

  10. I. Do chronic pain patients' perceptions about their preinjury jobs determine their intent to return to the same type of job post-pain facility treatment?

    Science.gov (United States)

    Fishbain, D A; Rosomoff, H L; Cutler, R B; Steele-Rosomoff, R

    1995-12-01

    To demonstrate that chronic pain patients' (CPPs') perceptions about their preinjury jobs determine their intent to return to the same type of job post pain facility treatment. A total of 225 CPPs completed a series of rating scales and yes/no questions relating to their preinjury job perceptions and a question relating to intent to return to the same type of preinjury job post-pain facility treatment. The CPPs were broken down into subgroups (males, females, college males, noncollege males, college females, noncollege females), and within each subgroup those not intending to return to the same type of pre-injury job were compared to those intending to return on the preinjury job perception questions. In addition for the whole group, stepwise discriminant analysis was used to predict who planned to return to the preinjury job utilizing the job perceptions questions. Multidisciplinary Pain Center. Consecutive chronic pain patients. For the whole group, CPPs not intending to return were more likely to complain of job excessive physical demands, job satisfaction, and job dislike. Job perception complaints that were significantly different between the intending and not intending to return groups differed between the subgroups. For example, noncollege males not intending to return were more likely to complain of excessive physical demands only versus satisfaction and liking as significant items for college males who did not intend to return. Within the discriminant analysis, the combination of job satisfaction, excessive physical demands, employee conflicts, job liking, job dangerousness, supervisory conflicts, job stress, and age classified 73.46% of the CPPs correctly as to intent to return to the same type of preinjury job. There appears to be a relationship between preinjury job perceptions and intent to return to the same type of job post pain treatment. However, subgroups of CPPs will differ by which job perceptions are important towards making that decision.

  11. Sensitivity to Nuclear Data and Neutron Source Type in Calculations of Transmutation Capabilities of the Energy Amplifier Demonstration Facility

    International Nuclear Information System (INIS)

    Dahlfors, Marcus

    2003-05-01

    This text is a summary of two studies the author has performed within the field of 3-D Monte Carlo calculations of Accelerator Driven Systems (ADS) for transmutation of nuclear waste. The simulations were carried out with the state-of-the-art computer code package EA-MC, developed by C. Rubbia and his group at CERN. The concept studied is ANSALDOs 80 MWth Energy Amplifier Demonstration Facility based on classical MOX-fuel technology and on molten Lead-Bismuth Eutectic cooling. A review of neutron cross section sensitivity in numerical calculations of an ADS and a comparative assessment relevant to the transmutation efficiency of plutonium and minor actinides in fusion/fission hybrids and ADS are presented

  12. Sensitivity to Nuclear Data and Neutron Source Type in Calculations of Transmutation Capabilities of the Energy Amplifier Demonstration Facility

    Energy Technology Data Exchange (ETDEWEB)

    Dahlfors, Marcus

    2003-05-01

    This text is a summary of two studies the author has performed within the field of 3-D Monte Carlo calculations of Accelerator Driven Systems (ADS) for transmutation of nuclear waste. The simulations were carried out with the state-of-the-art computer code package EA-MC, developed by C. Rubbia and his group at CERN. The concept studied is ANSALDOs 80 MWth Energy Amplifier Demonstration Facility based on classical MOX-fuel technology and on molten Lead-Bismuth Eutectic cooling. A review of neutron cross section sensitivity in numerical calculations of an ADS and a comparative assessment relevant to the transmutation efficiency of plutonium and minor actinides in fusion/fission hybrids and ADS are presented.

  13. Characteristic of muscle involvement evaluated by CT scans in early stages of progressive muscular dystrophy; Comparison between Duchenne and Fukuyama types

    Energy Technology Data Exchange (ETDEWEB)

    Arai, Yumi (Tokyo Women' s Medical Coll. (Japan))

    1993-10-01

    Muscle CT scans were performed in order to compare the characteristic distribution of progressive muscle involvement in the early stages of Duchenne type (DMD) and Fukuyama type muscular dystrophy (FCMD). Muscle images at the levels of the 3rd lumbar vertebra, thigh and calf were assessed by visual inspection, and mean CT numbers calculated for individual muscles were statistically analysed. On visual inspection, intramuscular low density areas and muscular atrophy were observed in the muscles of older patients with either disease. These changes were, however, more extensive at thigh level in DMD, and at calf level in FCMD. Nevertheless, the mean CT numbers of muscles in which only slight changes were grossly visible on CT scans displayed progressive decreases with increasing age. Moreover, a significant negative relationship was recognizable between age and mean CT number in almost all muscles examined. Comparison of the slopes of the regression lines revealed that the so-called selective pattern of muscle involvement characteristic of the symptomatic stage had already partially manifested in the preclinical or early stages of both diseases. In FCMD, the rates of decrease in CT numbers were extremely rapid for calf muscles as compared with those in DMD, indicating that this is one reason for FCMD patients never becoming ambulatory. However, for almost all of the other muscles, the CT numbers in FCMD decreased in parallel with the corresponding CT numbers in DMD; thus, these diseases displayed a similarity in the pattern of muscle involvement, despite their different pathogenetic mechanisms and inheritance patterns. (author).

  14. Facile synthesis of bismuth oxyhalide nanosheet films with distinct conduction type and photo-induced charge carrier behavior

    Science.gov (United States)

    Jia, Huimin; He, Weiwei; Zhang, Beibei; Yao, Lei; Yang, Xiaokai; Zheng, Zhi

    2018-05-01

    A modified successive ionic layer adsorption and reaction (SILAR) method was developed to fabricate 2D ordered BiOX (X = CI, Br, I) nanosheet array films on FTO substrates at room temperature. The formation of BiOX films were characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), high resolution transmission electron microscopy (HRTEM), UV-vis absorption spectroscopy, and X-ray photoelectron spectroscopy (XPS). The semiconductor surface states determine the type of semiconductor. Although BiOCI, BiOBr and BiOI belong to the bismuth oxyhalide semiconductor family and possess similar crystal and electronic structures, they show different conductivity types due to their respective surface states. Mott-Schottky curve results demonstrate that the BiOCl and BiOI nanosheet arrays display n-type semiconductor properties, while the BiOBr films exhibit p-type semiconductor properties. Assisted by surface photovoltage (SPV) and transient photovoltage (TPV) techniques, the photoinduced charge transfer dynamics on the surface/interface of the BiOX/FTO nanosheet films were systematically and comparatively investigated. As revealed by the results, both the separation and transfer dynamics of the photo-induced carrier are influenced by film thickness.

  15. Facile preparation of hierarchically porous diatomite/MFI-type zeolite composites and their performance of benzene adsorption: the effects of NaOH etching pretreatment.

    Science.gov (United States)

    Yu, Wenbin; Yuan, Peng; Liu, Dong; Deng, Liangliang; Yuan, Weiwei; Tao, Bo; Cheng, Hefa; Chen, Fanrong

    2015-03-21

    Hierarchically porous diatomite/MFI-type zeolite (Dt/Z) composites with excellent benzene adsorption performance were prepared. The hierarchical porosity was generated from the microporous zeolite coated at the surface of diatom frustules and from the macroporous diatomite support. A facile NaOH etching method was employed for the first time to treat the frustule support, followed by hydrothermal growth of MFI-type zeolite at the surface of frustules previously seeded with nanocrystalline silicalite-1 (Sil-1). NaOH etching enlarged the pores on diatom frustules and further increased the coated zeolite contents (W(z)). The central macropore size of the diatom frustules increased from approximately 200-500 nm to 400-1000 nm after NaOH etching. The W(z) could reach 61.2%, while the macroporosity of the composites was largely preserved due to more voids for zeolite coating being formed by NaOH etching. The Dt/Z composites exhibited higher benzene adsorption capacity per unit mass of zeolite and less mass transfer resistance than Sil-1, evaluated via a method of breakthrough curves. These results demonstrate that etching of a diatomite support is a facile but crucial process for the preparation of Dt/Z composites, enabling the resulting composites to become promising candidates for uses in volatile organic compounds emission control. Copyright © 2014 Elsevier B.V. All rights reserved.

  16. Spread of CTX-M-type ESßLs in isolates of E. coli from long-term care and rehabilitation facilities in Northern Italy

    Directory of Open Access Journals (Sweden)

    Elisabetta Nucleo

    2008-09-01

    Full Text Available During the period March 2003 – May 2004 at the Laboratory of Clinical Microbiology “Redaelli” LTCRF in Milan, Italy, a total of 529 E. coli, obtained from inpatients of 3 different Long Term Care Rehabilitation Facilities (LTCRFs in Northern Italy, were processed and 77 ESßLs producers (14.5% were identified by Vitek System. The results were confirmed by double-disk synergy test with tazobactam (TZP. 61/77 isolates were characterized by higher levels of resistance to cefotaxime (CTX than to ceftazidime (CAZ. (ß-lactamase production was investigated by analytical isoelectric focusing (IEF coupled with a bioassay and showed multiple (ß-lactamase bands including one enzyme with pI 8.4 that, in a bioassay, was more active on CTX,ATM than on CAZ. The presence of (ß-lactamase genes was investigated by colony blot hybridization and by PCR amplification of blaTEM, blaSHV and blaCTX-M alleles. 43/61 isolates produced both TEM-1 and CTX-M-type enzymes, 14/61 expressed only CTX-M-type while in 4 cases were found blaCTX-M, blaTEM and blaSHV genes.The remainders (16/77, characterized by high levels of resistance to both CTX and CAZ, produced TEM-1 and SHV-5 enzymes (1/16 and TEM type ESßLs (15/16. Conjugation experiments, performed in liquid medium, confermed that the ESßLs determinants were transferable. Pulsed-field gel electrophoresis profiles of genomic DNA, digested with NotI, were analysed and revealed clonal heterogeneity. Our work confirms the emergence of CTX-M-type enzymes and their spread in Northern Italy also in longterm care and rehabilitation facilities that may be an important reservoir of ES?L producing E. coli.

  17. Changes in feedwater organic matter concentrations based on intake type and pretreatment processes at SWRO facilities, Red Sea, Saudi Arabia

    KAUST Repository

    Dehwah, Abdullah

    2015-03-01

    Transparent exopolymer particles (TEP), natural organic matter, and bacterial concentrations in feedwater are important factors that can lead to membrane biofouling in seawater reverse osmosis (SWRO) systems. Two methods for controlling these concentrations in the feedwater prior to pretreatment have been suggested; use of subsurface intake systems or placement of the intake at a greater depth in the sea. These proposed solutions were tested at two SWRO facilities located along the Red Sea of Saudi Arabia. A shallow well intake system was very effective in reducing the algae and bacterial concentrations and somewhat effective in reducing TEP concentrations. An intake placed at a depth of 9. m below the surface was found to have limited impact on improving water quality compared to a surface intake. The algae and bacteria concentration in the feedwater (deep) was lower compared to the surface seawater, but the overall TEP concentration was higher. Bacteria and TEP measurements made in the pretreatment process train in the plant and after the cartridge filters suggest that regrowth of bacteria is occurring within the cartridge filters.

  18. Changes in feedwater organic matter concentrations based on intake type and pretreatment processes at SWRO facilities, Red Sea, Saudi Arabia

    KAUST Repository

    Dehwah, Abdullah; Li, Sheng; Almashharawi, Samir; Winters, Harvey; Missimer, Thomas M.

    2015-01-01

    Transparent exopolymer particles (TEP), natural organic matter, and bacterial concentrations in feedwater are important factors that can lead to membrane biofouling in seawater reverse osmosis (SWRO) systems. Two methods for controlling these concentrations in the feedwater prior to pretreatment have been suggested; use of subsurface intake systems or placement of the intake at a greater depth in the sea. These proposed solutions were tested at two SWRO facilities located along the Red Sea of Saudi Arabia. A shallow well intake system was very effective in reducing the algae and bacterial concentrations and somewhat effective in reducing TEP concentrations. An intake placed at a depth of 9. m below the surface was found to have limited impact on improving water quality compared to a surface intake. The algae and bacteria concentration in the feedwater (deep) was lower compared to the surface seawater, but the overall TEP concentration was higher. Bacteria and TEP measurements made in the pretreatment process train in the plant and after the cartridge filters suggest that regrowth of bacteria is occurring within the cartridge filters.

  19. Emission Facilities - Air Emission Plants

    Data.gov (United States)

    NSGIC Education | GIS Inventory — Represents the Primary Facility type Air Emission Plant (AEP) point features. Air Emissions Plant is a DEP primary facility type related to the Air Quality Program....

  20. Prostanoid-dependent bladder pain caused by proteinase-activated receptor-2 activation in mice: Involvement of TRPV1 and T-type Ca2+ channels

    Directory of Open Access Journals (Sweden)

    Maho Tsubota

    2018-01-01

    Full Text Available We studied the pronociceptive role of proteinase-activated receptor-2 (PAR2 in mouse bladder. In female mice, intravesical infusion of the PAR2-activating peptide, SLIGRL-amide (SL, caused delayed mechanical hypersensitivity in the lower abdomen, namely ‘referred hyperalgesia’, 6–24 h after the administration. The PAR2-triggered referred hyperalgesia was prevented by indomethacin or a selective TRPV1 blocker, and restored by a T-type Ca2+ channel blocker. In human urothelial T24 cells, SL caused delayed prostaglandin E2 production and COX-2 upregulation. Our data suggest that luminal PAR2 stimulation in the bladder causes prostanoid-dependent referred hyperalgesia in mice, which involves the activation of TRPV1 and T-type Ca2+ channels.

  1. Cholesteryl Ester Transfer Protein Intimately Involved in Dyslipidemia-Related Susceptibility to Cognitive Deficits in Type 2 Diabetic Patients.

    Science.gov (United States)

    Sun, Jie; Cai, Rongrong; Huang, Rong; Wang, Pin; Tian, Sai; Sun, Haixia; Xia, Wenqing; Wang, Shaohua

    2016-08-01

    Cholesteryl ester transfer protein (CETP) is involved in diabetic dyslipidemia. We aim to test the hypothesis that CETP might be of importance in mediating dyslipidemia-related susceptibility to cognitive deficits in diabetic patients. We recruited 190 type 2 diabetic patients and divided them into two groups according to the Montreal Cognitive Assessment (MoCA) score. The association between CETP and cognitive decline was analyzed with logistic regression and stratification. There were 110 diabetic patients with mild cognition impairment (MCI) and 80 healthy cognition subjects as controls. Dyslipidemia is more common among diabetic patients with MCI; they had a significant increase of serum CETP concentrations, which was negatively correlated with MoCA (r = -0.638; p dyslipidemia-related susceptibility to cognitive decline, especially memory function in type 2 diabetic patients.

  2. A novel soluble immune-type receptor (SITR in teleost fish: carp SITR is involved in the nitric oxide-mediated response to a protozoan parasite.

    Directory of Open Access Journals (Sweden)

    Carla M S Ribeiro

    2011-01-01

    Full Text Available The innate immune system relies upon a wide range of germ-line encoded receptors including a large number of immunoglobulin superfamily (IgSF receptors. Different Ig-like immune receptor families have been reported in mammals, birds, amphibians and fish. Most innate immune receptors of the IgSF are type I transmembrane proteins containing one or more extracellular Ig-like domains and their regulation of effector functions is mediated intracellularly by distinct stimulatory or inhibitory pathways.Carp SITR was found in a substracted cDNA repertoire from carp macrophages, enriched for genes up-regulated in response to the protozoan parasite Trypanoplasma borreli. Carp SITR is a type I protein with two extracellular Ig domains in a unique organisation of a N-proximal V/C2 (or I- type and a C-proximal V-type Ig domain, devoid of a transmembrane domain or any intracytoplasmic signalling motif. The carp SITR C-proximal V-type Ig domain, in particular, has a close sequence similarity and conserved structural characteristics to the mammalian CD300 molecules. By generating an anti-SITR antibody we could show that SITR protein expression was restricted to cells of the myeloid lineage. Carp SITR is abundantly expressed in macrophages and is secreted upon in vitro stimulation with the protozoan parasite T. borreli. Secretion of SITR protein during in vivo T. borreli infection suggests a role for this IgSF receptor in the host response to this protozoan parasite. Overexpression of carp SITR in mouse macrophages and knock-down of SITR protein expression in carp macrophages, using morpholino antisense technology, provided evidence for the involvement of carp SITR in the parasite-induced NO production.We report the structural and functional characterization of a novel soluble immune-type receptor (SITR in a teleost fish and propose a role for carp SITR in the NO-mediated response to a protozoan parasite.

  3. Technical support for GEIS: radioactive waste isolation in geologic formations. Volume 18. Facility construction feasibility and costs by rock type

    International Nuclear Information System (INIS)

    1978-04-01

    The results of a study that compared the general engineering feasibility and unit costs associated with sinking shafts and mining storage rooms in the four rock types (salt, granite, shale, basalt) are presented in this volume. The report includes a discussion of the general effects of rock characteristics on shaft and mine design, the application of these design considerations to the specific designs developed for the Draft GEIS, shaft and mine construction techniques, and the unit cost comparison. The repository designs upon which this comparison was based are presented in other volumes of this series

  4. Decommissioning of nuclear facilities by the United States Department of Energy Oak Ridge Field Office

    International Nuclear Information System (INIS)

    DeLozier, M.F.P.

    1992-01-01

    The Oak Ridge Field Office of the United States Department of Energy is projecting one of the largest decommissioning efforts in the nation during the next ten to twenty years. The nuclear facilities are varied with respect to the types of contaminants and types of structures and equipment involved. The facilities planned for decommissioning include 26 ORNL facilities (e.g., OGR, HRE, MSRE), 70 facilities at Oak Ridge K25 site, and the Y-12 plant at Oak Ridge. Innovative technologies are required to decommission the facilities and dispose of the waste generated. (R.P.)

  5. Thermography imaging during static and controlled thermoregulation in complex regional pain syndrome type 1: diagnostic value and involvement of the central sympathetic system

    Directory of Open Access Journals (Sweden)

    Westra Mirjam

    2006-05-01

    Full Text Available Abstract Background Complex Regional Pain Syndrome type 1 (CRPS1 is a clinical diagnosis based on criteria describing symptoms of the disease. The main aim of the present study was to compare the sensitivity and specificity of calculation methods used to assess thermographic images (infrared imaging obtained during temperature provocation. The secondary objective was to obtain information about the involvement of the sympathetic system in CRPS1. Methods We studied 12 patients in whom CRPS1 was diagnosed according to the criteria of Bruehl. High and low whole body cooling and warming induced and reduced sympathetic vasoconstrictor activity. The degree of vasoconstrictor activity in both hands was monitored using a videothermograph. The sensitivity and specificity of the calculation methods used to assess the thermographic images were calculated. Results The temperature difference between the hands in the CRPS patients increases significantly when the sympathetic system is provoked. At both the maximum and minimum vasoconstriction no significant differences were found in fingertip temperatures between both hands. Conclusion The majority of CRPS1 patients do not show maximal obtainable temperature differences between the involved and contralateral extremity at room temperature (static measurement. During cold and warm temperature challenges this temperature difference increases significantly. As a result a higher sensitivity and specificity could be achieved in the diagnosis of CRPS1. These findings suggest that the sympathetic efferent system is involved in CRPS1.

  6. Collagen type XI alpha1 may be involved in the structural plasticity of the vertebral column in Atlantic salmon (Salmo salar L.).

    Science.gov (United States)

    Wargelius, A; Fjelldal, P G; Nordgarden, U; Grini, A; Krossøy, C; Grotmol, S; Totland, G K; Hansen, T

    2010-04-01

    Atlantic salmon (Salmo salar L.) vertebral bone displays plasticity in structure, osteoid secretion and mineralization in response to photoperiod. Other properties of the vertebral bone, such as mineral content and mechanical strength, are also associated with common malformations in farmed Atlantic salmon. The biological mechanisms that underlie these changes in bone physiology are unknown, and in order to elucidate which factors might be involved in this process, microarray assays were performed on vertebral bone of Atlantic salmon reared under natural or continuous light. Eight genes were upregulated in response to continuous light treatment, whereas only one of them was upregulated in a duplicate experiment. The transcriptionally regulated gene was predicted to code for collagen type XI alpha1, a protein known to be involved in controlling the diameter of fibrillar collagens in mammals. Furthermore, the gene was highly expressed in the vertebrae, where spatial expression was found in trabecular and compact bone osteoblasts and in the chordoblasts of the notochordal sheath. When we measured the expression level of the gene in the tissue compartments of the vertebrae, the collagen turned out to be 150 and 25 times more highly expressed in the notochord and compact bone respectively, relative to the expression in the trabecular bone. Gene expression was induced in response to continuous light, and reduced in compressed vertebrae. The downregulation in compressed vertebrae was due to reduced expression in the compact bone, while expression in the trabecular bone and the notochord was unaffected. These data support the hypothesis that this gene codes for a presumptive collagen type XI alpha1, which may be involved in the regulatory pathway leading to structural adaptation of the vertebral architecture.

  7. Alkylated selenophene-based ladder-type monomers via a facile route for high performance thin-film transistor applications

    KAUST Repository

    Fei, Zhuping

    2017-05-26

    We report the synthesis of two new selenophene containing ladder-type monomers, cyclopentadiselenophene (CDS) and indacenodiselenophene (IDSe), via a twofold and fourfold Pd catalyzed coupling with a 1,1-diborylmethane derivative. Co-polymers with benzothiadiazole (BT) were prepared in high yield by Suzuki polymerization to afford co-polymers which exhibited excellent solubility in a range of non-chlorinated solvents. The CDS co-polymer exhibited a band gap of just 1.18 eV, which is amongst the lowest reported for donor-acceptor polymers. Thin-film transistors were fabricated using environmentally benign, non-chlorinated solvents with the CDS and IDSe co-polymers exhibiting hole mobility up to 0.15 and 6.4 cm2 /Vs, respectively. This high performance was achieved without the undesirable peak in mobility often observed at low gate voltages due to parasitic contact resistance.

  8. Alkylated selenophene-based ladder-type monomers via a facile route for high performance thin-film transistor applications

    KAUST Repository

    Fei, Zhuping; Han, Yang; Gann, Eliot; Hodsden, Thomas; Chesman, Anthony; McNeill, Christopher R.; Anthopoulos, Thomas D.; Heeney, Martin

    2017-01-01

    We report the synthesis of two new selenophene containing ladder-type monomers, cyclopentadiselenophene (CDS) and indacenodiselenophene (IDSe), via a twofold and fourfold Pd catalyzed coupling with a 1,1-diborylmethane derivative. Co-polymers with benzothiadiazole (BT) were prepared in high yield by Suzuki polymerization to afford co-polymers which exhibited excellent solubility in a range of non-chlorinated solvents. The CDS co-polymer exhibited a band gap of just 1.18 eV, which is amongst the lowest reported for donor-acceptor polymers. Thin-film transistors were fabricated using environmentally benign, non-chlorinated solvents with the CDS and IDSe co-polymers exhibiting hole mobility up to 0.15 and 6.4 cm2 /Vs, respectively. This high performance was achieved without the undesirable peak in mobility often observed at low gate voltages due to parasitic contact resistance.

  9. Application of SAFRAN Tool for the Knowledge Management at the Stage of Radioactive Waste Retrieval from Historical Radon-type Storage Facility

    International Nuclear Information System (INIS)

    Smetnik, A.; Murlis, D.

    2016-01-01

    Our task was to assess waste retrieval operations from a typical RADON-type historical waste storage facility during decommissioning. Challenges: “Historical radioactive waste” is generated without a complete traceable characterization programme or quality management system in place. Key characteristics of historical waste are: — may be conditioned, partially treated, or raw; — poor or no information/traceability; — cannot conclusively identify originating process/location; — waste streams may be mixed. Conclusions: • SAFRAN uses methodologies agreed upon at the international level, namely, by IAEA standards; • Several experts can work more effectively when performing the same safety assessment. SAFRAN makes it easier to exchange experience through sharing projects and data bases; • It is helpful for systematic and structured safety assessment as per safety standards; • It manages information and data in the same software environment. • SAFRAN can play a significant role in managing records and knowledge on radioactive waste, nuclear facility site, characteristics of geological environment and safety barriers. • It can provide reliable long-term storage and effective management of safety related records for the purposes of safety reassessments, review and supervision.

  10. Development of evaluation method for heat removal design of dry storage facilities. Pt. 4. Numerical analysis on vault storage system of cross flow type

    International Nuclear Information System (INIS)

    Sakamoto, Kazuaki; Hattori, Yasuo; Koga, Tomonari; Wataru, Masumi

    1999-01-01

    On the basis of the result of the heat removal test on vault storage system of cross flow type using the 1/5 scale model, an evaluation method for the heat removal design was established. It was composed of the numerical analysis for the convection phenomena of air flow inside the whole facility and that for the natural convection and the detailed turbulent mechanism near the surface of the storage tube. In the former analysis, air temperature distribution in the storage area obtained by the calculation gave good agreement within ±3degC with the test result. And fine turbulence models were introduced in the latter analysis to predict the separation flow in the boundary layer near the surface of the storage tube and the buoyant flow generated by the heat from the storage tube. Furthermore, the properties of removing the heat in a designed full-scale storage facility, such as flow pattern in the storage area, temperature and heat transfer rate of the storage tubes, were evaluated by using each of three methods, which were the established numerical analysis method, the experimental formula demonstrated in the heat removal test and the conventional evaluation method applied to the past heat removal design. As a result, the safety margin and issues included in the methods were grasped, and the measures to make a design more rational were proposed. (author)

  11. How often parametrial involvement leads to post-operative adjuvant treatment in locally advanced cervical cancer after neoadjuvant chemotherapy and type C radical hysterectomy?

    Science.gov (United States)

    Martinelli, F; Bogani, G; Ditto, A; Carcangiu, M; Papadia, A; Lecce, F; Chiappa, V; Lorusso, D; Raspagliesi, F

    2015-08-01

    Parametrial involvement (PMI) is one of the most important factors influencing prognosis in locally advanced stage cervical cancer (LACC) patients. We aimed to evaluate PMI rate among LACC patients undergoing neoadjuvant chemotherapy (NACT), thus evaluating the utility of parametrectomy in tailor adjuvant treatments. Retrospective evaluation of consecutive 275 patients affected by LACC (IB2-IIB), undergoing NACT followed by type C/class III radical hysterectomy. Basic descriptive statistics, univariate and multivariate analyses were applied in order to identify factors predicting PMI. Survival outcomes were assessed using Kaplan-Meier and Cox models. PMI was detected in 37 (13%) patients: it was associated with vaginal involvement, lymph node positivity and both in 10 (4%), 5 (2%) and 12 (4%) patients, respectively; while PMI alone was observed in only 10 (4%) patients. Among this latter group, adjuvant treatment was delivered in 3 (1%) patients on the basis of pure PMI; while the remaining patients had other characteristics driving adjuvant treatment. Considering factors predicting PMI we observed that only suboptimal pathological responses (OR: 1.11; 95% CI: 1.01, 1.22) and vaginal involvement (OR: 1.29 (95%) CI: 1.17, 1.44) were independently associated with PMI. PMI did not correlate with survival (HR: 2.0; 95% CI: 0.82, 4.89); while clinical response to NACT (HR: 3.35; 95% CI: 1.59, 7.04), vaginal involvement (HR: 2.38; 95% CI: 1.12, 5.02) and lymph nodes positivity (HR: 3.47; 95% CI: 1.62, 7.41), independently correlated with worse survival outcomes. Our data suggest that PMI had a limited role on the choice to administer adjuvant treatment, thus supporting the potential embrace of less radical surgery in LACC patients undergoing NACT. Further prospective studies are warranted. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. High-throughput typing method to identify a non-outbreak-involved Legionella pneumophila strain colonizing the entire water supply system in the town of Rennes, France.

    Science.gov (United States)

    Sobral, D; Le Cann, P; Gerard, A; Jarraud, S; Lebeau, B; Loisy-Hamon, F; Vergnaud, G; Pourcel, C

    2011-10-01

    Two legionellosis outbreaks occurred in the city of Rennes, France, during the past decade, requiring in-depth monitoring of Legionella pneumophila in the water network and the cooling towers in the city. In order to characterize the resulting large collection of isolates, an automated low-cost typing method was developed. The multiplex capillary-based variable-number tandem repeat (VNTR) (multiple-locus VNTR analysis [MLVA]) assay requiring only one PCR amplification per isolate ensures a high level of discrimination and reduces hands-on and time requirements. In less than 2 days and using one 4-capillary apparatus, 217 environmental isolates collected between 2000 and 2009 and 5 clinical isolates obtained during outbreaks in 2000 and 2006 in Rennes were analyzed, and 15 different genotypes were identified. A large cluster of isolates with closely related genotypes and representing 77% of the population was composed exclusively of environmental isolates extracted from hot water supply systems. It was not responsible for the known Rennes epidemic cases, although strains showing a similar MLVA profile have regularly been involved in European outbreaks. The clinical isolates in Rennes had the same genotype as isolates contaminating a mall's cooling tower. This study further demonstrates that unknown environmental or genetic factors contribute to the pathogenicity of some strains. This work illustrates the potential of the high-throughput MLVA typing method to investigate the origin of legionellosis cases by allowing the systematic typing of any new isolate and inclusion of data in shared databases.

  13. Thermal Response of Whipox-Type All-Oxide Ceramic Matrix Composites during Reentry Simulation in the Dlr-Lbk Arc-Heated Facility

    Science.gov (United States)

    Mechnich, P.; Braue, W.; Schneider, H.; Koch, U.; Esser, B.; Gülhan, A.

    2005-02-01

    All-oxide ceramic matrix composites (CMCs) such as WHIPOXTM (wound highly porous oxide) exhibit excellent damage tolerance and thermal stability up to 1400°C. Due to their low density and thermal conductivity these new ceramic materials are considered promising candidates for thermal protection systems (TPS) of spacecrafts. The performance of WHIPOX-type CMCs was evaluated during reentry simulations in the L2K leg of the arc-heated LBK facility of DLR, Cologne. The application of reaction-bonded alumina (RBAO) coatings provides significant CMC surface protection and decreased gas permeability, which are key issues for reentry applications. Since emittance and catalycity of the RBAO-coatings limit the performance of CMCs in a reentry environment, binary SiC/RBAO coatings providing higher emittance and/or lower catalycity proved to be a promising approach.

  14. Development of the radiation models of a BWR type reactor and it facility in the SUN-RAH

    International Nuclear Information System (INIS)

    Barron A, I.

    2005-01-01

    This work about generation models, transport in processes and radioactive contamination of areas of a BWR central, is an amplification to the project developed in the UNAM to have a support tool in subjects or electric generation courses. It is planned about the implementation of models of radiation generation in a BWR type reactor for complement the functions developed in the University Simulator of Nucleo electric- Boiling water reactor (SUN-RAH) which it has been implemented in Simulink of MatLab and it has a model for the dynamics of one nucleo electric central that presents the main characteristics of the reactor vessel, the recirculation system, steam lines, turbines, generator, condensers and feeding water, defined by the main processes that intervene in the generation of energy of these plants. By this way the radiation monitoring systems for area and process, operate simultaneously with the processes of energy generation, with that is possible to observe the changes that present with respect to the operation conditions of the plant, and likewise to appreciate the radiation transport process through the components of the reactor, steam lines and turbines, for different operation conditions and possible faults that they could be presented during the reactor operation. (Author)

  15. [Supply and demand of medical specialists in the health facilities of the Ministry of Health: national, regional and by type of specialty gaps].

    Science.gov (United States)

    Zevallos, Leslie; Pastor, Reyna; Moscoso, Betsy

    2011-06-01

    To characterize the supply, demand and the gap of medical specialists in facilities of the Ministry of Health of Peru (MINSA) at the national, regional and specialty type levels. Observational, descriptive study through which we calculated the supply of medical specialists using secondary sources of MINSA. The analysis of the demand for medical specialists was based on two methodologies: the need for specialists according to the guidelines of classification of the health facilities and according to the epidemiological and demographic profile. The arithmetic difference between the estimated demand and the supply was the procedure used to calculate the gap of medical specialists. The Ministry of Health has a total supply at the national level of 6,074 medical specialists of which 61.5% belong to the clinical specialties, 33.2% to the surgical specialties, 4.9% specialities related to aid to diagnosis and treatment and 0.4% to public health specialties. According to the categorization guideline there is a total demand of 11,176 medical specialists and according to the epidemiological and demographic profile of 11,738. The national estimated gaps found are similar in both methods, although they differ widely across regions and by type of specialty. At the regional level, the gaps are greater in Loreto, Piura, Puno and Madre de Dios when estimating the defficit in relation to the supply. Regarding the speciality, the gap is greater in the four basic specialties: gynecology and obstetrics, pediatrics, internal medicine and general surgery. There is a waid gap between supply and demand of medical specialists at the national and regional levels, as a whole representing approximately 45% of the current offer, regardless of the estimation method.

  16. Influence of Soap Characteristics and Food Service Facility Type on the Degree of Bacterial Contamination of Open, Refillable Bulk Soaps.

    Science.gov (United States)

    Schaffner, Donald W; Jensen, Dane; Gerba, Charles P; Shumaker, David; Arbogast, James W

    2018-02-01

    Concern has been raised regarding the public health risks from refillable bulk-soap dispensers because they provide an environment for potentially pathogenic bacteria to grow. This study surveyed the microbial quality of open refillable bulk soap in four different food establishment types in three states. Two hundred ninety-six samples of bulk soap were collected from food service establishments in Arizona, New Jersey, and Ohio. Samples were tested for total heterotrophic viable bacteria, Pseudomonas, coliforms and Escherichia coli, and Salmonella. Bacteria were screened for antibiotic resistance. The pH, solids content, and water activity of all soap samples were measured. Samples were assayed for the presence of the common antibacterial agents triclosan and parachlorometaxylenol. More than 85% of the soap samples tested contained no detectable microorganisms, but when a sample contained any detectable microorganisms, it was most likely contaminated at a very high level (∼7 log CFU/mL). Microorganisms detected in contaminated soap included Klebsiella oxytoca, Serratia liquefaciens, Shigella sonnei, Enterobacter gergoviae, Serratia odorifera, and Enterobacter cloacae. Twenty-three samples contained antibiotic-resistant organisms, some of which were resistant to two or more antibiotics. Every sample containing less than 4% solids had some detectable level of bacteria, whereas no samples with greater than 14% solids had detectable bacteria. This finding suggests the use of dilution and/or low-cost formulations as a cause of bacterial growth. There was a statistically significant difference ( P = 0.0035) between the fraction of bacteria-positive samples with no detected antimicrobial agent (17%) and those containing an antimicrobial agent (7%). Fast food operations and grocery stores were more likely to have detectable bacteria in bulk-soap samples compared with convenience stores ( P food service establishments.

  17. Diabetic retinopathy and its risk factors in patients with type 2 diabetes attending rural primary healthcare facilities in Tamil Nadu.

    Science.gov (United States)

    Fredrick, Tony; Kaur, Prabhdeep; Murhekar, Manoj V; Jayaraman, Yuvaraj; Kolandaswamy, K; Rao, Sudha Ramachandra; David, Joseph K

    2016-01-01

    India has a high burden of diabetic retinopathy ranging from 12.2% to 20.4% among patients with type 2 diabetes mellitus (T2DM). A T2DM management programme was initiated in the public sector in Tamil Nadu. We estimated the prevalence of diabetic retinopathy and its associated risk factors. We did a cross-sectional survey among patients with T2DM attending two primary health centres for treatment and follow-up in Kancheepuram, Tamil Nadu in January- March 2013. We did a questionnaire-based survey, and measured blood pressure and biochemical parameters (serum creatinine, plasma glucose, etc.) of the patients. We examined their eyes by direct and indirect ophthalmoscopy and defined diabetic retinopathy using a modified classification by Klein et al. We calculated the proportion and 95% CI for the prevalence and adjusted odds ratio (AOR) for risk factors associated with diabetic retinopathy. Among the 270 patients, the mean (SD) age was 54.5 (10) years. The median duration of T2DM was 48 months. The prevalence of diabetic retinopathy was 29.6%. Overall, 65.9% of patients had hypertension, 14.4% had nephropathy (eGFR 5 years (AOR 6.5, 95% CI 3.6-11.7), poor glycaemic control (AOR 2.4, 95% CI 1.4-4.4), and nephropathy (AOR 2.3, 95% CI 1.1-4.6). There was a high burden of undetected retinopathy and other comorbid conditions among patients with T2DM. Early detection of comorbid conditions and glycaemic control can be improved by training care-providers and educating patients.

  18. Identifying the Integrated Neural Networks Involved in Capsaicin-Induced Pain Using fMRI in Awake TRPV1 Knockout and Wild-Type Rats

    Directory of Open Access Journals (Sweden)

    Jason Richard Yee

    2015-02-01

    Full Text Available In the present study, we used functional MRI in awake rats to investigate the pain response that accompanies intradermal injection of capsaicin into the hindpaw. To this end, we used BOLD imaging together with a 3D segmented, annotated rat atlas and computational analysis to identify the integrated neural circuits involved in capsaicin-induced pain. The specificity of the pain response to capsaicin was tested in a transgenic model that contains a biallelic deletion of the gene encoding for the transient receptor potential cation channel subfamily V member 1 (TRPV1. Capsaicin is an exogenous ligand for the TRPV1 receptor, and in wild-type rats, activated the putative pain neural circuit. In addition, capsaicin-treated wild-type rats exhibited activation in brain regions comprising the Papez circuit and habenular system, systems that play important roles in the integration of emotional information, and learning and memory of aversive information, respectively. As expected, capsaicin administration to TRPV1-KO rats failed to elicit the robust BOLD activation pattern observed in wild-type controls. However, the intradermal injection of formalin elicited a significant activation of the putative pain pathway as represented by such areas as the anterior cingulate, somatosensory cortex, parabrachial nucleus, and periaqueductal gray. Notably, comparison of neural responses to capsaicin in wild-type versus knock-out rats uncovered evidence that capsaicin may function in an antinociceptive capacity independent of TRPV1 signaling. Our data suggest that neuroimaging of pain in awake, conscious animals has the potential to inform the neurobiological basis of full and integrated perceptions of pain.

  19. New Ideas on Facilities Management.

    Science.gov (United States)

    Grimm, James C.

    1986-01-01

    Examines trends in facilities management relating to products and people. Reviews new trends in products, including processes, techniques, and programs that are being expounded by business and industry. Discusses the "people factors" involved in facilities management. (ABB)

  20. Diagnostic Value of N Terminal Pro B Type Natriuretic Peptide (NT-pro BNP in Cardiac Involvement in Patients with Beta- Thalassemia

    Directory of Open Access Journals (Sweden)

    Noor Mohammad Noori

    2017-04-01

    Full Text Available Background Heart failure is a major cause of death in thalassemia. The study aimed to determine the diagnostic value of N Terminal Pro B Type Natriuretic Peptide (NT-pro BNP, to early diagnose the cardiac involvement in beta- thalassemia major patients. Materials and Methods  80 thalassemia patients aged 7 to 18 years old (patients group, and 80 healthy age and gender matched controls were enrolled in the case-control study. Patients were selected from those attending to the clinic of Aliasghar hospital, Zahedan-Iran. They were subjected to echo-Doppler tissue and conventional examination for both right and left heart function. Data were analysis using SPSS 18.0 software. Results  NT-pro BNP increased in patients compared the controls (P

  1. A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion

    DEFF Research Database (Denmark)

    Faassen, A E; Schrager, J A; Klein, D J

    1992-01-01

    The metastatic spread of tumor cells occurs through a complex series of events, one of which involves the adhesion of tumor cells to extracellular matrix (ECM) components. Multiple interactions between cell surface receptors of an adherent tumor cell and the surrounding ECM contribute to cell...... collagen could also be inhibited by removing cell surface chondroitin sulfate with chondroitinase. In contrast, type I collagen-mediated melanoma cell adhesion and spreading were not affected by either beta-D-xyloside or chondroitinase treatments. These results suggest that mouse melanoma CSPG...... was shown to be mediated, at least in part, by chondroitin sulfate. Additionally we have determined that mouse melanoma CSPG is composed of a 110-kD core protein that is recognized by anti-CD44 antibodies on Western blots. Collectively, our data suggests that interactions between a cell surface CD44-related...

  2. Facility of aerosol filtration

    Energy Technology Data Exchange (ETDEWEB)

    Duverger de Cuy, G; Regnier, J

    1975-04-18

    Said invention relates to a facility of aerosol filtration, particularly of sodium aerosols. Said facility is of special interest for fast reactors where sodium fires involve the possibility of high concentrations of sodium aerosols which soon clog up conventional filters. The facility intended for continuous operation, includes at the pre-filtering stage, means for increasing the size of the aerosol particles and separating clustered particles (cyclone separator).

  3. Novel C-2 epimerization of aldoses promoted by nickel(II) diamine complexes, involving a stereospecific pinacol-type 1,2-carbon shift

    International Nuclear Information System (INIS)

    Tanase, Tomoaki; Shimizu, Fumihiko; Kuse, Manabu; Yano, Shigenobu; Hidai, Masanobu; Yoshikawa, Sadao

    1988-01-01

    The newly discovered C-2 epimerization of aldoses promoted by nickel(II) diamine complexes has been investigated in detail by using 13 C-enriched D-glucose, 13 C NMR spectroscopy, and EXAFS (extended x-ray absorption fine structure) analysis. Aldoses treated with nickel(II) diamine complexes (diamine = N,N,N'-trimethylethylenediamine (N,N,N'-Me 3 en), N,N,N',N'-tetramethylethylenediamine (N,N,N',N'-Me 4 en), etc.) in methanolic solutions were rapidly (60 degree C, 3-5 min) epimerized at C-2 to give equilibrium mixtures where the ratio of C-2 epimers shifts to the side of the naturally rare mannose-type aldoses (having the cis arrangement of C-2 and C-3 hydroxyl groups) compared with those in the thermodynamic equilibrium states. The epimerization product of D-[1- 13 C]glucose was exclusively D-[2- 13 C]mannose, demonstrating that the reaction involves a stereospecific 1,2-shift of the carbon skeleton resulting in inversion of configuration at C-2. Furthermore, the absorption and circular dichroism spectra of the reaction solutions indicated the presence of an intermediate nickel(II) complex containing both diamine and sugar components, which was directly revealed by EXAFS analysis to be a mononuclear nickel(II) complex having octahedral coordination geometry. All these observations strongly suggest that the C-2 epimerization proceeds through an intermediate mononuclear nickel(II) complex, where the carbinolamine-like adduct of aldose with diamine in an open-chain form is epimerized at C-2 by a stereospecific rearrangement of the carbon skeleton or a pinacol-type rearrangement involving a cyclic transition state. 44 refs., 5 figs., 4 tabs

  4. An S-type anion channel SLAC1 is involved in cryptogein-induced ion fluxes and modulates hypersensitive responses in tobacco BY-2 cells.

    Science.gov (United States)

    Kurusu, Takamitsu; Saito, Katsunori; Horikoshi, Sonoko; Hanamata, Shigeru; Negi, Juntaro; Yagi, Chikako; Kitahata, Nobutaka; Iba, Koh; Kuchitsu, Kazuyuki

    2013-01-01

    Pharmacological evidence suggests that anion channel-mediated plasma membrane anion effluxes are crucial in early defense signaling to induce immune responses and hypersensitive cell death in plants. However, their molecular bases and regulation remain largely unknown. We overexpressed Arabidopsis SLAC1, an S-type anion channel involved in stomatal closure, in cultured tobacco BY-2 cells and analyzed the effect on cryptogein-induced defense responses including fluxes of Cl(-) and other ions, production of reactive oxygen species (ROS), gene expression and hypersensitive responses. The SLAC1-GFP fusion protein was localized at the plasma membrane in BY-2 cells. Overexpression of SLAC1 enhanced cryptogein-induced Cl(-) efflux and extracellular alkalinization as well as rapid/transient and slow/prolonged phases of NADPH oxidase-mediated ROS production, which was suppressed by an anion channel inhibitor, DIDS. The overexpressor also showed enhanced sensitivity to cryptogein to induce downstream immune responses, including the induction of defense marker genes and the hypersensitive cell death. These results suggest that SLAC1 expressed in BY-2 cells mediates cryptogein-induced plasma membrane Cl(-) efflux to positively modulate the elicitor-triggered activation of other ion fluxes, ROS as well as a wide range of defense signaling pathways. These findings shed light on the possible involvement of the SLAC/SLAH family anion channels in cryptogein signaling to trigger the plasma membrane ion channel cascade in the plant defense signal transduction network.

  5. Lower Squalene Epoxidase and Higher Scavenger Receptor Class B Type 1 Protein Levels Are Involved in Reduced Serum Cholesterol Levels in Stroke-Prone Spontaneously Hypertensive Rats.

    Science.gov (United States)

    Michihara, Akihiro; Mido, Mayuko; Matsuoka, Hiroshi; Mizutani, Yurika

    2015-01-01

    A lower serum cholesterol level was recently shown to be one of the causes of stroke in an epidemiological study. Spontaneously hypertensive rats stroke-prone (SHRSP) have lower serum cholesterol levels than normotensive Wistar-Kyoto rats (WKY). To elucidate the mechanisms responsible for the lower serum cholesterol levels in SHRSP, we determined whether the amounts of cholesterol biosynthetic enzymes or the receptor and transporter involved in cholesterol uptake and efflux in the liver were altered in SHRSP. When the mRNA levels of seven cholesterol biosynthetic enzymes were measured using real-time polymerase chain reaction (PCR), farnesyl pyrophosphate synthase and squalene epoxidase (SQE) levels in the liver of SHRSP were significantly lower than those in WKY. SQE protein levels were significantly reduced in tissues other than the brain of SHRSP. No significant differences were observed in low-density lipoprotein (LDL) receptor (uptake of serum LDL-cholesterol) or ATP-binding cassette transporter A1 (efflux of cholesterol from the liver/formation of high-density lipoprotein (HDL)) protein levels in the liver and testis between SHRSP and WKY, whereas scavenger receptor class B type 1 (SRB1: uptake of serum HDL-cholesterol) protein levels were higher in the livers of SHRSP. These results indicated that the lower protein levels of SQE and higher protein levels of SRB1 in the liver were involved in the reduced serum cholesterol levels in SHRSP.

  6. Safety of magnetic fusion facilities: Guidance

    International Nuclear Information System (INIS)

    1996-05-01

    This document provides guidance for the implementation of the requirements identified in DOE-STD-6002-96, Safety of Magnetic Fusion Facilities: Requirements. This guidance is intended for the managers, designers, operators, and other personnel with safety responsibilities for facilities designated as magnetic fusion facilities. While the requirements in DOE-STD-6002-96 are generally applicable to a wide range of fusion facilities, this Standard, DOE-STD-6003-96, is concerned mainly with the implementation of those requirements in large facilities such as the International Thermonuclear Experimental Reactor (ITER). Using a risk-based prioritization, the concepts presented here may also be applied to other magnetic fusion facilities. This Standard is oriented toward regulation in the Department of Energy (DOE) environment as opposed to regulation by other regulatory agencies. As the need for guidance involving other types of fusion facilities or other regulatory environments emerges, additional guidance volumes should be prepared. The concepts, processes, and recommendations set forth here are for guidance only. They will contribute to safety at magnetic fusion facilities

  7. Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41

    International Nuclear Information System (INIS)

    Anastassopoulou, Cleo G.; Ketas, Thomas J.; Depetris, Rafael S.; Thomas, Antonia M.; Klasse, Per Johan; Moore, John P.

    2011-01-01

    Here, we describe the genetic pathways taken by a human immunodeficiency virus type 1 (HIV-1) isolate, D101.12, to become resistant to the small molecule CCR5 inhibitor, vicriviroc (VCV), in vitro. Resistant D101.12 variants contained at least one substitution in the gp120 V3 region (H308P), plus one of two patterns of gp41 sequence changes involving the fusion peptide (FP) and a downstream residue: G514V+V535M or M518V+F519L+V535M. Studies of Env-chimeric and point-substituted viruses in peripheral blood mononuclear cells (PBMC) and TZM-bl cells showed that resistance can arise from the cooperative action of gp120 and gp41 changes, while retaining CCR5 usage. Modeling the VCV inhibition data from the two cell types suggests that D101.12 discriminates between high- and low-VCV affinity forms of CCR5 less than D1/85.16, a resistant virus with three FP substitutions.

  8. M-type thioredoxins are involved in the xanthophyll cycle and proton motive force to alter NPQ under low-light conditions in Arabidopsis.

    Science.gov (United States)

    Da, Qingen; Sun, Ting; Wang, Menglong; Jin, Honglei; Li, Mengshu; Feng, Dongru; Wang, Jinfa; Wang, Hong-Bin; Liu, Bing

    2018-02-01

    M-type thioredoxins are required to regulate zeaxanthin epoxidase activity and to maintain the steady-state level of the proton motive force, thereby influencing NPQ properties under low-light conditions in Arabidopsis. Non-photochemical quenching (NPQ) helps protect photosynthetic organisms from photooxidative damage via the non-radiative dissipation of energy as heat. Energy-dependent quenching (qE) is a major constituent of NPQ. However, the mechanism underlying the regulation of qE is not well understood. In this study, we demonstrate that the m-type thioredoxins TRX-m1, TRX-m2, and TRX-m4 (TRX-ms) interact with the xanthophyll cycle enzyme zeaxanthin epoxidase (ZE) and are required for maintaining the redox-dependent stabilization of ZE by regulating its intermolecular disulfide bridges. Reduced ZE activity and accumulated zeaxanthin levels were observed under TRX-ms deficiency. Furthermore, concurrent deficiency of TRX-ms resulted in a significant increase in proton motive force (pmf) and acidification of the thylakoid lumen under low irradiance, perhaps due to the significantly reduced ATP synthase activity under TRX-ms deficiency. The increased pmf, combined with acidification of the thylakoid lumen and the accumulation of zeaxanthin, ultimately contribute to the elevated stable qE in VIGS-TRX-m2m4/m1 plants under low-light conditions. Taken together, these results indicate that TRX-ms are involved in regulating NPQ-dependent photoprotection in Arabidopsis.

  9. First evidence of a potential antibacterial activity involving a laccase-type enzyme of the phenoloxidase system in Pacific oyster Crassostrea gigas haemocytes.

    Science.gov (United States)

    Luna-Acosta, Andrea; Saulnier, Denis; Pommier, Mylène; Haffner, Philippe; De Decker, Sophie; Renault, Tristan; Thomas-Guyon, Hélène

    2011-12-01

    Phenoloxidases (POs) are a group of copper proteins including tyrosinase, catecholase and laccase. In several insects and crustaceans, antibacterial substances are produced through the PO cascade, participating in the direct killing of invading microorganisms. However, although POs are widely recognised as an integral part of the invertebrate immune defence system, experimental evidence is lacking that these properties are conserved in molluscs, and more particularly in the Pacific oyster Crassostrea gigas. In the present study, Vibrio splendidus LGP32 and Vibrio aestuarianus 02/041 growths were affected, after being treated with C. gigas haemocyte lysate supernatant (HLS), and either a common substrate of POs, l-3,4-dihydroxyphenylalanine (L-DOPA), to detect catecholase-type PO activity, or a specific substrate of laccase, p-phenylenediamine (PPD), to detect laccase-type PO activity. Interestingly, a higher bacterial growth inhibition was observed in the presence of PPD than in the presence of L-DOPA. These effects were suppressed when the specific PO inhibitor, phenylthiourea (PTU), was added to the medium. Results of the present study suggest, for the first time in a mollusc species, that antibacterial activities of HLS from C. gigas potentially involve POs, and more particularly laccase catalysed reactions. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Genetic Variants Involved in Mitochondrial Oxidative Metabolism are associated with Type 2 Diabetes Mellitus in studies of 9,132 Danes

    DEFF Research Database (Denmark)

    Snogdal, Lena Sønder

    Genetic Variants Involved in Mitochondrial Oxidative Metabolism are associated with Type 2 Diabetes Mellitus in studies of 9,132 Danes Lena Soender Snogdal, Mette Wod, Marie Vestmar, Thomas Sparsø, Daniel R Witte, Torben Jørgensen, Torsten Lauritzen, Anneli Sandbæk, Niels Grarup, Henning Beck......; Research Centre for Prevention and Health, Glostrup University Hospital, Denmark; Faculty of Health Sciences, University of Aarhus, Denmark; Faculty of Health Sciences, University of Aarhus, Denmark Type 2 Diabetes (T2D) is characterized by insulin resistance and failure of the pancreatic beta cells......, the rs9915302 variant in COX10 showed strong association with T2D (OR=1.14, p=7.7x10-6). Our data suggest that genetic variants in or near genes encoding subunits in complex IV (COX5B, COX6B1, COX10) contribute to the pathogenesis of T2D. The observed association of variants in COX5B, COX10 and NDUFV3...

  11. Development of evaluation method for heat removal design of dry storage facilities. pt. 1. Heat removal test on vault storage system of cross flow type

    International Nuclear Information System (INIS)

    Sakamoto, Kazuaki; Koga, Tomonari; Wataru, Masumi; Hattori, Yasuo

    1997-01-01

    The report describes the result of heat removal test of passive cooling vault storage system of cross flow type using 1/5 scale model. Based on a prospect of steady increase in the amount of spent fuel, it is needed to establish large capacity dry storage technologies for spent fuel. Air flow patterns, distributions of air temperature and velocity were measured, by which heat removal characteristics of the system were made clear. Air flow patterns in the storage module depended on the ratio of the buoyant force to the inertial force; the former generated by the difference of air temperatures and the height of the storage module, the latter by the difference of air densities between the outlet of the storage module and ambience and the height of the chimney of the storage facility. A simple method to estimate air flow patterns in the storage module was suggested, where Ri(Richardson) number was applied to represent the ratio. Moreover, heat transfer coefficient from a model of storage tube to cooling air was evaluated, and it was concluded that the generalized expression of heat transfer coefficient for common heat exchangers could be applied to the vault storage system of cross flow type, in which dozens of storage tubes were placed in a storage module. (author)

  12. Is Office-Based Surgery Safe? Comparing Outcomes of 183,914 Aesthetic Surgical Procedures Across Different Types of Accredited Facilities.

    Science.gov (United States)

    Gupta, Varun; Parikh, Rikesh; Nguyen, Lyly; Afshari, Ashkan; Shack, R Bruce; Grotting, James C; Higdon, K Kye

    2017-02-01

    There has been a dramatic rise in office-based surgery. However, due to wide variations in regulatory standards, the safety of office-based aesthetic surgery has been questioned. This study compares complication rates of cosmetic surgery performed at office-based surgical suites (OBSS) to ambulatory surgery centers (ASCs) and hospitals. A prospective cohort of patients undergoing cosmetic surgery between 2008 and 2013 were identified from the CosmetAssure database (Birmingham, AL). Patients were grouped by type of accredited facility where the surgery was performed: OBSS, ASC, or hospital. The primary outcome was the incidence of major complication(s) requiring emergency room visit, hospital admission, or reoperation within 30 days postoperatively. Potential risk factors including age, gender, body mass index (BMI), smoking, diabetes, type of procedure, and combined procedures were reviewed. Of the 129,007 patients (183,914 procedures) in the dataset, the majority underwent the procedure at ASCs (57.4%), followed by hospitals (26.7%) and OBSS (15.9%). Patients operated in OBSS were less likely to undergo combined procedures (30.3%) compared to ASCs (31.8%) and hospitals (35.3%, P procedures. Plastic surgeons should continue to triage their patients carefully based on other significant comorbidities that were not measured in this present study. LEVEL OF EVIDENCE 3. © 2016 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com.

  13. Facilities & Leadership

    Data.gov (United States)

    Department of Veterans Affairs — The facilities web service provides VA facility information. The VA facilities locator is a feature that is available across the enterprise, on any webpage, for the...

  14. In vivo versus in vitro protein abundance analysis of Shigella dysenteriae type 1 reveals changes in the expression of proteins involved in virulence, stress and energy metabolism

    Directory of Open Access Journals (Sweden)

    Donohue-Rolfe Arthur

    2011-06-01

    Full Text Available Abstract Background Shigella dysenteriae serotype 1 (SD1 causes the most severe form of epidemic bacillary dysentery. Quantitative proteome profiling of Shigella dysenteriae serotype 1 (SD1 in vitro (derived from LB cell cultures and in vivo (derived from gnotobiotic piglets was performed by 2D-LC-MS/MS and APEX, a label-free computationally modified spectral counting methodology. Results Overall, 1761 proteins were quantitated at a 5% FDR (false discovery rate, including 1480 and 1505 from in vitro and in vivo samples, respectively. Identification of 350 cytoplasmic membrane and outer membrane (OM proteins (38% of in silico predicted SD1 membrane proteome contributed to the most extensive survey of the Shigella membrane proteome reported so far. Differential protein abundance analysis using statistical tests revealed that SD1 cells switched to an anaerobic energy metabolism under in vivo conditions, resulting in an increase in fermentative, propanoate, butanoate and nitrate metabolism. Abundance increases of transcription activators FNR and Nar supported the notion of a switch from aerobic to anaerobic respiration in the host gut environment. High in vivo abundances of proteins involved in acid resistance (GadB, AdiA and mixed acid fermentation (PflA/PflB indicated bacterial survival responses to acid stress, while increased abundance of oxidative stress proteins (YfiD/YfiF/SodB implied that defense mechanisms against oxygen radicals were mobilized. Proteins involved in peptidoglycan turnover (MurB were increased, while β-barrel OM proteins (OmpA, OM lipoproteins (NlpD, chaperones involved in OM protein folding pathways (YraP, NlpB and lipopolysaccharide biosynthesis (Imp were decreased, suggesting unexpected modulations of the outer membrane/peptidoglycan layers in vivo. Several virulence proteins of the Mxi-Spa type III secretion system and invasion plasmid antigens (Ipa proteins required for invasion of colonic epithelial cells, and release

  15. Biochemistry Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Biochemistry Facility provides expert services and consultation in biochemical enzyme assays and protein purification. The facility currently features 1) Liquid...

  16. Solid Waste Management Facilities with Permits by the Iowa DNR

    Data.gov (United States)

    Iowa State University GIS Support and Research Facility — All types of facilities that handle solid waste, including: sanitary landfills, appliance demanufacturing facilities, transfer stations, land application sites,...

  17. Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in type II diabetics with rotator cuff disease.

    Science.gov (United States)

    Handa, Akiyoshi; Gotoh, Masafumi; Hamada, Kazutoshi; Yanagisawa, Kazuhiro; Yamazaki, Hitoshi; Nakamura, Masato; Ueyama, Yoshito; Mochida, Joji; Fukuda, Hiroaki

    2003-11-01

    Vascular endothelial growth factor (VEGF) is a glycoprotein that plays an important role in neovascularization and increases vascular permeability. We reported that VEGF is involved in motion pain of patients with rotator cuff disease by causing synovial proliferation in the subacromial bursa (SAB). The present study investigates whether VEGF is also involved in the development of shoulder contracture in diabetics with rotator cuff disease. We examined 67 patients with rotator cuff disease, including 36 with complete cuff tears, 20 with incomplete tears, and 11 without apparent tears (subacromial bursitis). The patients were into groups according to the presence or absence of diabetes (14 type II diabetics and 53 non-diabetics). Specimens of the synovium of the SAB were obtained from all patients during surgery. Expression of the VEGF gene in the synovium of the subacromial bursa was evaluated by using the reverse transcriptase polymerase chain reaction. The VEGF protein was localized by immunohistochemistry, and the number of vessels was evaluated based on CD34 immunoreactivity. The results showed that VEGF mRNA was expressed in significantly more diabetics (100%, 14/14) than in non-diabetics (70%, 37/53) (P=0.0159, Fisher's test). Investigation of VEGF isoform expression revealed VEGF121 in all 14 diabetics and in 37 of the 53 non-diabetics, VEGF165 in 12 of the 14 diabetics and in 21 of the 53 non-diabetics, and VEGF189 in 1 of the 14 diabetics and in 2 of the 53 non-diabetics. No VEGF206 was expressed in either group. VEGF protein was localized in both vascular endothelial cells and synovial lining cells. The mean number of VEGF-positive vessels and the vessel area were also significantly greater in the diabetics (pshoulder joint contracture were more common in the diabetics (P=0.0329 and P=0.073, respectively; Fisher's test). The mean preoperative range of shoulder motion significantly differed in terms of elevation between two groups: 103.8 degrees in

  18. Audits of radiation sterilization facilities

    International Nuclear Information System (INIS)

    Kelkar, Prabhakar M.

    2001-01-01

    Johnson and Johnson is the world leader in sterilization science and technology. A special group of scientists and technologists are engaged in the development of new methods of sterilization, worldwide monitoring of sterilization processes, equipment and approvals for all types of sterilization processes. Kilmer Conference in the alternate year for the benefit of all those involved in improvement in sterilization science is held. Cobalt-60 gamma radiation for sterilization of medical products on commercial scale is used. This kind of mammoth task can only be achieved through systematic method of planning, auditing, expert review and approval of facilities

  19. Effectiveness of a Treatment Involving Soft Tissue Techniques and/or Neural Mobilization Techniques in the Management of Tension-Type Headache: A Randomized Controlled Trial.

    Science.gov (United States)

    Ferragut-Garcías, Alejandro; Plaza-Manzano, Gustavo; Rodríguez-Blanco, Cleofás; Velasco-Roldán, Olga; Pecos-Martín, Daniel; Oliva-Pascual-Vaca, Jesús; Llabrés-Bennasar, Bartomeu; Oliva-Pascual-Vaca, Ángel

    2017-02-01

    To evaluate the effects of a protocol involving soft tissue techniques and/or neural mobilization techniques in the management of patients with frequent episodic tension-type headache (FETTH) and those with chronic tension-type headache (CTTH). Randomized, double-blind, placebo-controlled before and after trial. Rehabilitation area of the local hospital and a private physiotherapy center. Patients (N=97; 78 women, 19 men) diagnosed with FETTH or CTTH were randomly assigned to groups A, B, C, or D. (A) Placebo superficial massage; (B) soft tissue techniques; (C) neural mobilization techniques; (D) a combination of soft tissue and neural mobilization techniques. The pressure pain threshold (PPT) in the temporal muscles (points 1 and 2) and supraorbital region (point 3), the frequency and maximal intensity of pain crisis, and the score in the Headache Impact Test-6 (HIT-6) were evaluated. All variables were assessed before the intervention, at the end of the intervention, and 15 and 30 days after the intervention. Groups B, C, and D had an increase in PPT and a reduction in frequency, maximal intensity, and HIT-6 values in all time points after the intervention as compared with baseline and group A (P<.001 for all cases). Group D had the highest PPT values and the lowest frequency and HIT-6 values after the intervention. The application of soft tissue and neural mobilization techniques to patients with FETTH or CTTH induces significant changes in PPT, the characteristics of pain crisis, and its effect on activities of daily living as compared with the application of these techniques as isolated interventions. Copyright © 2016 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.

  20. Increased Erythrocytes By-Products of Arginine Catabolism Are Associated with Hyperglycemia and Could Be Involved in the Pathogenesis of Type 2 Diabetes Mellitus

    Science.gov (United States)

    Ramírez-Zamora, Serafín; Méndez-Rodríguez, Miguel L.; Olguín-Martínez, Marisela; Sánchez-Sevilla, Lourdes; Quintana-Quintana, Miguel; García-García, Norberto; Hernández-Muñoz, Rolando

    2013-01-01

    Diabetes mellitus (DM) is a worldwide disease characterized by metabolic disturbances, frequently associated with high risk of atherosclerosis and renal and nervous system damage. Here, we assessed whether metabolites reflecting oxidative redox state, arginine and nitric oxide metabolism, are differentially distributed between serum and red blood cells (RBC), and whether significant metabolism of arginine exists in RBC. In 90 patients with type 2 DM without regular treatment for diabetes and 90 healthy controls, paired by age and gender, we measured serum and RBC levels of malondialdehyde (MDA), nitrites, ornithine, citrulline, and urea. In isolated RBC, metabolism of L-[14C]-arginine was also determined. In both groups, nitrites were equally distributed in serum and RBC; citrulline predominated in serum, whereas urea, arginine, and ornithine were found mainly in RBC. DM patients showed hyperglycemia and increased blood HbA1C, and increased levels of these metabolites, except for arginine, significantly correlating with blood glucose levels. RBC were observed to be capable of catabolizing arginine to ornithine, citrulline and urea, which was increased in RBC from DM patients, and correlated with an increased affinity for arginine in the activities of putative RBC arginase (Km = 0.23±0.06 vs. 0.50±0.13 mM, in controls) and nitric oxide synthase (Km = 0.28±0.06 vs. 0.43±0.09 mM, in controls). In conclusion, our results suggest that DM alters metabolite distribution between serum and RBC, demonstrating that RBC regulate serum levels of metabolites which affect nitrogen metabolism, not only by transporting them but also by metabolizing amino acids such as arginine. Moreover, we confirmed that urea can be produced also by human RBC besides hepatocytes, being much more evident in RBC from patients with type 2 DM. These events are probably involved in the specific physiopathology of this disease, i.e., endothelial damage and dysfunction. PMID:23826148

  1. The structure of classical swine fever virus N(pro: a novel cysteine Autoprotease and zinc-binding protein involved in subversion of type I interferon induction.

    Directory of Open Access Journals (Sweden)

    Keerthi Gottipati

    Full Text Available Pestiviruses express their genome as a single polypeptide that is subsequently cleaved into individual proteins by host- and virus-encoded proteases. The pestivirus N-terminal protease (N(pro is a cysteine autoprotease that cleaves between its own C-terminus and the N-terminus of the core protein. Due to its unique sequence and catalytic site, it forms its own cysteine protease family C53. After self-cleavage, N(pro is no longer active as a protease. The released N(pro suppresses the induction of the host's type-I interferon-α/β (IFN-α/β response. N(pro binds interferon regulatory factor-3 (IRF3, the key transcriptional activator of IFN-α/β genes, and promotes degradation of IRF3 by the proteasome, thus preventing induction of the IFN-α/β response to pestivirus infection. Here we report the crystal structures of pestivirus N(pro. N(pro is structurally distinct from other known cysteine proteases and has a novel "clam shell" fold consisting of a protease domain and a zinc-binding domain. The unique fold of N(pro allows auto-catalysis at its C-terminus and subsequently conceals the cleavage site in the active site of the protease. Although many viruses interfere with type I IFN induction by targeting the IRF3 pathway, little information is available regarding structure or mechanism of action of viral proteins that interact with IRF3. The distribution of amino acids on the surface of N(pro involved in targeting IRF3 for proteasomal degradation provides insight into the nature of N(pro's interaction with IRF3. The structures thus establish the mechanism of auto-catalysis and subsequent auto-inhibition of trans-activity of N(pro, and its role in subversion of host immune response.

  2. Dance Facilities.

    Science.gov (United States)

    Ashton, Dudley, Ed.; Irey, Charlotte, Ed.

    This booklet represents an effort to assist teachers and administrators in the professional planning of dance facilities and equipment. Three chapters present the history of dance facilities, provide recommended dance facilities and equipment, and offer some adaptations of dance facilities and equipment, for elementary, secondary and college level…

  3. Process for decontamination of surfaces in an facility of natural uranium hexafluoride production (UF6)

    International Nuclear Information System (INIS)

    Almeida, Claudio C. de; Silva, Teresinha M.; Rodrigues, Demerval L.; Carneiro, Janete C.G.G.

    2017-01-01

    The experience acquired in the actions taken during the decontamination process of an IPEN-CNEN / SP Nuclear and Energy Research Institute facility, for the purpose of making the site unrestricted, is reported. The steps of this operation involved: planning, training of facility operators, workplace analysis and radiometric measurements. The facility had several types of equipment from the natural uranium hexafluoride (UF 6 ) production tower and other facility materials. Rules for the transportation of radioactive materials were established, both inside and outside the facility and release of materials and installation

  4. A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

    Directory of Open Access Journals (Sweden)

    Yanagihara Kazuyoshi

    2009-06-01

    Full Text Available Abstract Background Gastric cancer is the third most common malignancy affecting the general population worldwide. Aberrant activation of KRAS is a key factor in the development of many types of tumor, however, oncogenic mutations of KRAS are infrequent in gastric cancer. We have developed a novel quantitative method of analysis of DNA copy number, termed digital genome scanning (DGS, which is based on the enumeration of short restriction fragments, and does not involve PCR or hybridization. In the current study, we used DGS to survey copy-number alterations in gastric cancer cells. Methods DGS of gastric cancer cell lines was performed using the sequences of 5000 to 15000 restriction fragments. We screened 20 gastric cancer cell lines and 86 primary gastric tumors for KRAS amplification by quantitative PCR, and investigated KRAS amplification at the DNA, mRNA and protein levels by mutational analysis, real-time PCR, immunoblot analysis, GTP-RAS pull-down assay and immunohistochemical analysis. The effect of KRAS knock-down on the activation of p44/42 MAP kinase and AKT and on cell growth were examined by immunoblot and colorimetric assay, respectively. Results DGS analysis of the HSC45 gastric cancer cell line revealed the amplification of a 500-kb region on chromosome 12p12.1, which contains the KRAS gene locus. Amplification of the KRAS locus was detected in 15% (3/20 of gastric cancer cell lines (8–18-fold amplification and 4.7% (4/86 of primary gastric tumors (8–50-fold amplification. KRAS mutations were identified in two of the three cell lines in which KRAS was amplified, but were not detected in any of the primary tumors. Overexpression of KRAS protein correlated directly with increased KRAS copy number. The level of GTP-bound KRAS was elevated following serum stimulation in cells with amplified wild-type KRAS, but not in cells with amplified mutant KRAS. Knock-down of KRAS in gastric cancer cells that carried amplified wild-type

  5. A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth

    International Nuclear Information System (INIS)

    Mita, Hiroaki; Yanagihara, Kazuyoshi; Fujita, Masahiro; Hosokawa, Masao; Kusano, Masanobu; Sabau, Sorin Vasile; Tatsumi, Haruyuki; Imai, Kohzoh; Shinomura, Yasuhisa; Tokino, Takashi; Toyota, Minoru; Aoki, Fumio; Akashi, Hirofumi; Maruyama, Reo; Sasaki, Yasushi; Suzuki, Hiromu; Idogawa, Masashi; Kashima, Lisa

    2009-01-01

    Gastric cancer is the third most common malignancy affecting the general population worldwide. Aberrant activation of KRAS is a key factor in the development of many types of tumor, however, oncogenic mutations of KRAS are infrequent in gastric cancer. We have developed a novel quantitative method of analysis of DNA copy number, termed digital genome scanning (DGS), which is based on the enumeration of short restriction fragments, and does not involve PCR or hybridization. In the current study, we used DGS to survey copy-number alterations in gastric cancer cells. DGS of gastric cancer cell lines was performed using the sequences of 5000 to 15000 restriction fragments. We screened 20 gastric cancer cell lines and 86 primary gastric tumors for KRAS amplification by quantitative PCR, and investigated KRAS amplification at the DNA, mRNA and protein levels by mutational analysis, real-time PCR, immunoblot analysis, GTP-RAS pull-down assay and immunohistochemical analysis. The effect of KRAS knock-down on the activation of p44/42 MAP kinase and AKT and on cell growth were examined by immunoblot and colorimetric assay, respectively. DGS analysis of the HSC45 gastric cancer cell line revealed the amplification of a 500-kb region on chromosome 12p12.1, which contains the KRAS gene locus. Amplification of the KRAS locus was detected in 15% (3/20) of gastric cancer cell lines (8–18-fold amplification) and 4.7% (4/86) of primary gastric tumors (8–50-fold amplification). KRAS mutations were identified in two of the three cell lines in which KRAS was amplified, but were not detected in any of the primary tumors. Overexpression of KRAS protein correlated directly with increased KRAS copy number. The level of GTP-bound KRAS was elevated following serum stimulation in cells with amplified wild-type KRAS, but not in cells with amplified mutant KRAS. Knock-down of KRAS in gastric cancer cells that carried amplified wild-type KRAS resulted in the inhibition of cell growth and

  6. Oral bacteria influenced by the functional status of the elderly people and the type and quality of facilities for the bedridden.

    Science.gov (United States)

    Tada, A; Watanabe, T; Yokoe, H; Hanada, N; Tanzawa, H

    2002-01-01

    To analyse the relationship between oral bacteria and the health and functional status of the elderly. The bacteria species in the oral cavity of the elderly were examined. It was found that the bedridden subjects staying at two hospitals for long-term (HOBR) showed significantly lower detection rates of commensal bacteria species and significantly higher detection rates of Pseudomonas aeruginosa, of methicillin-resistant Staphylococcus aureus (MRSA) and of coagulase(-) Staph. aureus than those living independently (the independent). In addition, the detection rate of Haemophilus parainfluenzae in NUBR was discovered to be higher than that found in the independent. In HOBR, the detection rate of Ps. aeruginosa was significantly higher among in-patients who required continual care than those in need of partial care, while the detection rate of MRSA was significantly higher among in-patients with low serum albumin than those with normal serum albumin. Oral bacteria examination analysis proved that the risks of infection of some pathogenic bacteria species were correlated with functional status, physical function and nutritional state. Our study suggests that the oral bacteria, especially pathogenic bacteria were influenced by the functional status of the elderly and the type and quality of the facilities for the bedridden, physical function and nutritional state.

  7. Epidemiology and Characteristics of Escherichia coli Sequence Type 131 (ST131) from Long-Term Care Facility Residents Colonized Intestinally with Fluoroquinolone-Resistant Escherichia coli

    Science.gov (United States)

    Han, Jennifer H.; Garrigan, Charles; Johnston, Brian; Nachamkin, Irving; Clabots, Connie; Bilker, Warren B.; Santana, Evelyn; Tolomeo, Pam; Maslow, Joel; Myers, Janice; Carson, Lesley; Lautenbach, Ebbing; Johnson, James R.

    2016-01-01

    The objective of this study was to evaluate molecular and epidemiologic factors associated with Escherichia coli sequence type 131 (ST131) among long-term care facility (LTCF) residents who acquired gastrointestinal tract colonization with fluoroquinolone-resistant E. coli (FQREC). Colonizing isolates from 37 residents who newly developed FQREC colonization at three LTCFs from 2006–2008 were evaluated. Twenty-nine (78%) of 37 total FQREC colonizing isolates were ST131. Most ST131 isolates had a distinctive combination of gyrA and parC replacement mutations. The ST131 and non-ST131 isolates differed significantly for the prevalence of many individual virulence factors but not for the proportion that qualified molecularly as extraintestinal pathogenic E. coli (ExPEC) or aggregate virulence factor scores. E. coli ST131 was highly prevalent among LTCF residents with FQREC colonization. Future studies should determine the risk factors for infection among ST131-colonized residents, and assess the potential for increased transmissibility of ST131 in the long-term care setting. PMID:27939288

  8. Evaluating the sensitivity of EQ-5D in a sample of patients with type 2 diabetes mellitus in two tertiary health care facilities in Nigeria.

    Science.gov (United States)

    Ekwunife, Obinna Ikechukwu; Ezenduka, Charles C; Uzoma, Bede Emeka

    2016-01-12

    The EQ-5D instrument is arguably the most well-known and commonly used generic measure of health status internationally. Although the instrument has been employed in outcomes studies of diabetes mellitus in many countries, it has not yet been used in Nigeria. This study was carried out to assess the sensitivity of the EQ-5D instrument in a sample of Nigerian patients with type 2 diabetes mellitus (T2DM). A cross-sectional study was conducted using the EQ-5D instrument to assess the self-reported quality of life of patients with T2DM attending two tertiary healthcare facilities in south eastern Nigeria consenting patients completed the questionnaire while waiting to see a doctor. A priori hypotheses were examined using multiple regression analysis to model the relationship between the dependent variables (EQ VAS and EQ-5D Index) and hypothesized independent variables. A total of 226 patients with T2DM participated in the study. The average age of participants was 57 years (standard deviation 10 years) and 61.1% were male. The EQ VAS score and EQ-5D index averaged 66.19 (standard deviation 15.42) and 0.78 (standard deviation 0.21) respectively. Number of diabetic complications, number of co-morbidities, patient's age and being educated predicted EQ VAS score by -6.76, -6.15, -0.22, and 4.51 respectively. Also, number of diabetic complications, number of co-morbidities, patient's age and being educated predicted EQ-5D index by -0.12, -0.07, -0.003, and 0.06 respectively.. Our findings indicate that the EQ-5D could adequately capture the burden of type 2 diabetes and related complications among Nigerian patients.

  9. Public involvement in the siting of contentious facilities; Lessons from the radioactive waste repository siting programmes in Canada and the United States, with special reference to the Swedish repository siting process

    International Nuclear Information System (INIS)

    Richardson, P.J.

    1997-08-01

    This report describes the conclusion of a two-part programme, begun in 1994 with the overall aim of assisting in the development of an acceptable public participation strategy for use in Sweden for the siting of contentious facilities, with particular reference to the ongoing siting programme for a deep repository for spent nuclear fuel. The first part of the work programme, a global review of siting practice, was reported as SSI Rapport 94-15, in November 1994. This recommended further detailed studies of at least two individual programmes, which have now been carried out in Canada and the United States, and are reported on here. They involved face to face meetings with many of the main stake holders in the two programmes and enabled valuable insight to be gained into the potential problems associated with increased public participation, as well as identifying good practice where it exists. The lessons learned have then been applied to the evolving repository siting process in Sweden. 35 refs

  10. Public involvement in the siting of contentious facilities; Lessons from the radioactive waste repository siting programmes in Canada and the United States, with special reference to the Swedish repository siting process

    Energy Technology Data Exchange (ETDEWEB)

    Richardson, P J [Geosciences for Development and the Environment (United Kingdom)

    1997-08-01

    This report describes the conclusion of a two-part programme, begun in 1994 with the overall aim of assisting in the development of an acceptable public participation strategy for use in Sweden for the siting of contentious facilities, with particular reference to the ongoing siting programme for a deep repository for spent nuclear fuel. The first part of the work programme, a global review of siting practice, was reported as SSI Rapport 94-15, in November 1994. This recommended further detailed studies of at least two individual programmes, which have now been carried out in Canada and the United States, and are reported on here. They involved face to face meetings with many of the main stake holders in the two programmes and enabled valuable insight to be gained into the potential problems associated with increased public participation, as well as identifying good practice where it exists. The lessons learned have then been applied to the evolving repository siting process in Sweden. 35 refs.

  11. Structural Test Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Provides a wide variety of testing equipment, fixtures and facilities to perform both unique aviation component testing as well as common types of materials testing...

  12. Facility transition instruction

    International Nuclear Information System (INIS)

    Morton, M.R.

    1997-01-01

    The Bechtel Hanford, Inc. facility transition instruction was initiated in response to the need for a common, streamlined process for facility transitions and to capture the knowledge and experience that has accumulated over the last few years. The instruction serves as an educational resource and defines the process for transitioning facilities to long-term surveillance and maintenance (S and M). Generally, these facilities do not have identified operations missions and must be transitioned from operational status to a safe and stable configuration for long-term S and M. The instruction can be applied to a wide range of facilities--from process canyon complexes like the Plutonium Uranium Extraction Facility or B Plant, to stand-alone, lower hazard facilities like the 242B/BL facility. The facility transition process is implemented (under the direction of the US Department of Energy, Richland Operations Office [RL] Assistant Manager-Environmental) by Bechtel Hanford, Inc. management, with input and interaction with the appropriate RL division and Hanford site contractors as noted in the instruction. The application of the steps identified herein and the early participation of all organizations involved are expected to provide a cost-effective, safe, and smooth transition from operational status to deactivation and S and M for a wide range of Hanford Site facilities

  13. The Effects of Argument Quality and Involvement Type on Attitude Formation and Attitude Change: A Test of Dual-Process and Social Judgment Predictions

    Science.gov (United States)

    Park, Hee Sun; Levine, Timothy R.; Kingsley Westerman, Catherine Y.; Orfgen, Tierney; Foregger, Sarah

    2007-01-01

    Involvement has long been theoretically specified as a crucial factor determining the persuasive impact of messages. In social judgment theory, ego-involvement makes people more resistant to persuasion, whereas in dual-process models, high-involvement people are susceptible to persuasion when argument quality is high. It is argued that these…

  14. Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism

    DEFF Research Database (Denmark)

    Hernández-Alvarez, María Isabel; Díaz-Ramos, Angels; Berdasco, María

    2017-01-01

    The molecular mechanisms responsible for the pathophysiological traits of type 2 diabetes are incompletely understood. Here we have performed transcriptomic analysis in skeletal muscle, and plasma metabolomics from subjects with classical and early-onset forms of type 2 diabetes (T2D). Focused...... of type 2 diabetes, and this occurs both in early-onset and in classical type 2 diabetes....

  15. Genetic Variability of the Glucose-Dependent Insulinotropic Peptide Gene Is Involved in the Premature Coronary Artery Disease in a Chinese Population with Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Xiaowei Ma

    2018-01-01

    Full Text Available Background. Glucose-dependent insulinotropic polypeptide (GIP is closely related to diabetes and obesity, both of which are confirmed to increase the risk of coronary artery disease (CAD. Our study aimed to investigate whether the polymorphisms in GIP genes could affect the risk of cardiovascular disease in type 2 diabetic patients in the Chinese Han population. Methods. We selected and genotyped two haplotype-tagging single nucleotide polymorphisms (tag-SNPs (rs2291725 C>T, rs8078510 G>A of GIP gene based on CHB data in HapMap Phase II database (r2<0.8. The case-control study of Chinese Han population involved 390 diabetic patients with CAD as positive group and 276 diabetic patients without CAD as control group. Allele and genotype frequencies were compared between the two groups. Results. In dominant inheritance model, the carriers of T/T or T/C had a lower risk of CAD (OR = 0.635, 95% CI = 0.463–0.872, p=0.005, even after adjustment other CAD risk factors (gender, age, BMI, smoking status, dyslipidemia, hypertension history, and diabetic duration (OR′ = 0.769, 95% CI′ = 0.626–0.945, p′=0.013. The allele A at rs8078510 was associated with decreased risk of CAD (OR = 0.732, p=0.039. p=0.018 in subgroup analysis, individuals with higher BMI (≥24 kg/m2 had increased risk for CAD when carrying C/C at rs2291725 (OR′ = 1.291, 95% CI′ = 1.017–1.639, p′=0.036. In age < 55 men and age < 65 women, the carriers of allele C at rs2291725 had a higher risk of CAD than noncarriers (OR = 1.627, p=0.015. Carriers of allele G in rs8078510 had higher susceptibility to CAD (OR = 2.049, 95% = CI 1.213–3.463, p=0.007. p=0.004; in addition, allele G in rs8078510 would bring higher CAD risk to the carriers who ever smoked (OR = 1.695, 95% CI = 1.080–2.660, p=0.021. Conclusion. The genetic variability of GIP gene is associated with CAD and it may play a role in the premature CAD in the

  16. Type IX secretion: the generation of bacterial cell surface coatings involved in virulence, gliding motility and the degradation of complex biopolymers.

    Science.gov (United States)

    Veith, Paul D; Glew, Michelle D; Gorasia, Dhana G; Reynolds, Eric C

    2017-10-01

    The Type IX secretion system (T9SS) is present in over 1000 sequenced species/strains of the Fibrobacteres-Chlorobi-Bacteroidetes superphylum. Proteins secreted by the T9SS have an N-terminal signal peptide for translocation across the inner membrane via the SEC translocon and a C-terminal signal for secretion across the outer membrane via the T9SS. Nineteen protein components of the T9SS have been identified including three, SigP, PorX and PorY that are involved in regulation. The inner membrane proteins PorL and PorM and the outer membrane proteins PorK and PorN interact and a complex comprising PorK and PorN forms a large ring structure of 50 nm in diameter. PorU, PorV, PorQ and PorZ form an attachment complex on the cell surface of the oral pathogen, Porphyromonas gingivalis. P. gingivalis T9SS substrates bind to PorV suggesting that after translocation PorV functions as a shuttle protein to deliver T9SS substrates to the attachment complex. The PorU component of the attachment complex is a novel Gram negative sortase which catalyses the cleavage of the C-terminal signal and conjugation of the protein substrates to lipopolysaccharide, anchoring them to the cell surface. This review presents an overview of the T9SS focusing on the function of T9SS substrates and machinery components. © 2017 John Wiley & Sons Ltd.

  17. Involvement of the Niacin Receptor GPR109a in the LocalControl of Glucose Uptake in Small Intestine of Type 2Diabetic Mice

    Directory of Open Access Journals (Sweden)

    Tung Po Wong

    2015-09-01

    Full Text Available Niacin is a popular nutritional supplement known to reduce the risk of cardiovascular diseases by enhancing high-density lipoprotein levels. Despite such health benefits, niacin impairs fasting blood glucose. In type 2 diabetes (T2DM, an increase in jejunal glucose transport has been well documented; however, this is intriguingly decreased during niacin deficient state. In this regard, the role of the niacin receptor GPR109a in T2DM jejunal glucose transport remains unknown. Therefore, the effects of diabetes and high-glucose conditions on GPR109a expression were studied using jejunal enterocytes of 10-week-old m+/db and db/db mice, as well as Caco-2 cells cultured in 5.6 or 25.2 mM glucose concentrations. Expression of the target genes and proteins were quantified using real-time polymerase chain reaction (RT-PCR and Western blotting. Glucose uptake in Caco-2 cells and everted mouse jejunum was measured using liquid scintillation counting. 10-week T2DM increased mRNA and protein expression levels of GPR109a in jejunum by 195.0% and 75.9%, respectively, as compared with the respective m+/db control; high-glucose concentrations increased mRNA and protein expression of GPR109a in Caco-2 cells by 130.2% and 69.0%, respectively, which was also confirmed by immunohistochemistry. In conclusion, the enhanced GPR109a expression in jejunal enterocytes of T2DM mice and high-glucose treated Caco-2 cells suggests that GPR109a is involved in elevating intestinal glucose transport observed in diabetes.

  18. Decommissioning of nuclear facilities: a growing activity in the world

    International Nuclear Information System (INIS)

    Anasco, Raul

    2001-01-01

    Nuclear power plants and nuclear facilities are no different from normal buildings and factories. Eventually, they become worn-out or old fashioned, too expensive to maintain or remodel. Decommissioning a nuclear facility is different from retiring other types because of the radioactivity involved. The most important consideration in nuclear decommissioning is to protect workers and the public from exposure to harmful levels of radiation. General criteria and strategies for the decommissioning of nuclear facilities are described as well as the present decommissioning activities of the Argentine CNEA (author)

  19. Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins.

    Science.gov (United States)

    Böhnlein, E; Siekevitz, M; Ballard, D W; Lowenthal, J W; Rimsky, L; Bogérd, H; Hoffman, J; Wano, Y; Franza, B R; Greene, W C

    1989-04-01

    The human immunodeficiency virus type 1 (HIV-1) preferentially infects CD4+ T lymphocytes and may exist as a latent provirus within these cells for extended periods. The transition to a productive retroviral infection results in T-cell death and clinically may lead to the acquired immune deficiency syndrome. Accelerated production of infectious HIV-1 virions appears to be closely linked to a heightened state of T-cell activation. The transactivator (Tax) protein of the type I human T-cell leukemia virus (HTLV-I) can produce such an activated T-cell phenotype and augments activity of the HIV-1 long terminal repeat. One Tax-responsive region within the HIV-1 long terminal repeat has been mapped to a locus composed of two 10-base-pair direct repeats sharing homology with the binding site for the eucaryotic transcription factor NF-kappaB (GGGACTTTCC). Tax-expressing Jurkat T cells contain one or more inducible cellular proteins that specifically associate with the HIV-1 enhancer at these binding sites. Microscale DNA affinity precipitation assays identified a Tax-inducible 86-kilodalton protein, HIVEN86A, as one of these HIV-1 enhancer-binding factors. The interaction of HIVEN86A, and presumably other cellular proteins, with the HIV-1 enhancer appears functionally important as oligonucleotides corresponding to this enhancer were sufficient to impart Tax inducibility to an unresponsive heterologous promoter. These findings suggest that the Tax-inducible cellular protein HIVEN86A plays an important role in the transcriptional activation of the HIV-1 enhancer. These specific protein-DNA interactions may also be important for the transition of HIV-1 from a latent to a productive mode of infection. Furthermore, these findings highlight an intriguing biological interplay between HTLV-1 and HIV-1 through a cellular transcriptional pathway that is normally involved in T-cell activation and growth.

  20. Waste Facilities

    Data.gov (United States)

    Vermont Center for Geographic Information — This dataset was developed from the Vermont DEC's list of certified solid waste facilities. It includes facility name, contact information, and the materials...

  1. Health Facilities

    Science.gov (United States)

    Health facilities are places that provide health care. They include hospitals, clinics, outpatient care centers, and specialized care centers, ... psychiatric care centers. When you choose a health facility, you might want to consider How close it ...

  2. Fabrication Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — The Fabrication Facilities are a direct result of years of testing support. Through years of experience, the three fabrication facilities (Fort Hood, Fort Lewis, and...

  3. Uso de incrustaciones de resina compuesta tipo onlay en molares estructuralmente comprometidos Use of onlay-type composite resin inlays in structurally involved molars

    Directory of Open Access Journals (Sweden)

    Alberto Carlos Cruz González

    2012-03-01

    contraction at large sections of material polymerized outside the dental cavity. The objective of this article was to show the use of the composite with indirect technique how an alternative to easy handle and significant clinical results with the structural involvement of molars. The article reports two cases of composite resin inlay onlay in two permanent molars structurally affected, one endodontically treated. The collection of models is performed by the arch alginate impression of the teeth selected, making silicone light casting the prepared tooth and the rest in type III dental stone to obtain a die of work on drawing up the inlay in incremental technique. The cementation process oral cavity is carried out with dual cure resin cement. To control at six months for signs of a leak or marginal jet we used air-dried syringe, explorer and periapical X-Ray. The clinical examination and radiographic analysis revealed a good performance of the restorations in the absence of mismatch or marginal pigmentation. In conclusions the use of the composite inlays in molars with structural involvement with indirect technique is an alternative to easy handle and significant clinical results.

  4. Status of RIB facilities in Asia

    International Nuclear Information System (INIS)

    Tanihata, Isao

    1998-01-01

    Radioactive Ion Beam Facilities in Asia are presented. In China, in-flight separation type facilities are in operation at the Institute of Modern Physics in Lanzhou and the other at Tandem facility in China Institute of Atomic Energy in Beijing. The storage-ring facility is proposed and approved in Lanzhou. In India, the Variable Energy Cyclotron Facility in Calcutta start to construct an ISOL-type facility. In Japan, in-flight separation type facilities are working at Research Center for Nuclear Physics in Osaka, and at RIKEN. Also a separator start its operation in medical facility in Chiba. In RIKEN, the construction of RI Beam Factory has been started. An ISOL-type facility is proposed in the Japan Hadron Facility in KEK. Table I summarize these facilities

  5. Which Type of Risk Information to Use for Whom? Moderating Role of Outcome-Relevant Involvement in the Effects of Statistical and Exemplified Risk Information on Risk Perceptions.

    Science.gov (United States)

    So, Jiyeon; Jeong, Se-Hoon; Hwang, Yoori

    2017-04-01

    The extant empirical research examining the effectiveness of statistical and exemplar-based health information is largely inconsistent. Under the premise that the inconsistency may be due to an unacknowledged moderator (O'Keefe, 2002), this study examined a moderating role of outcome-relevant involvement (Johnson & Eagly, 1989) in the effects of statistical and exemplified risk information on risk perception. Consistent with predictions based on elaboration likelihood model (Petty & Cacioppo, 1984), findings from an experiment (N = 237) concerning alcohol consumption risks showed that statistical risk information predicted risk perceptions of individuals with high, rather than low, involvement, while exemplified risk information predicted risk perceptions of those with low, rather than high, involvement. Moreover, statistical risk information contributed to negative attitude toward drinking via increased risk perception only for highly involved individuals, while exemplified risk information influenced the attitude through the same mechanism only for individuals with low involvement. Theoretical and practical implications for health risk communication are discussed.

  6. Stress Survival Islet 2, Predominantly Present in Listeria monocytogenes Strains of Sequence Type 121, Is Involved in the Alkaline and Oxidative Stress Responses.

    Science.gov (United States)

    Harter, Eva; Wagner, Eva Maria; Zaiser, Andreas; Halecker, Sabrina; Wagner, Martin; Rychli, Kathrin

    2017-08-15

    The foodborne pathogen Listeria monocytogenes is able to survive a variety of stress conditions leading to the colonization of different niches like the food processing environment. This study focuses on the hypervariable genetic hot spot lmo0443 to lmo0449 haboring three inserts: the stress survival islet 1 (SSI-1), the single-gene insert LMOf2365_0481 , and two homologous genes of the nonpathogenic species Listeria innocua : lin0464 , coding for a putative transcriptional regulator, and lin0465 , encoding an intracellular PfpI protease. Our prevalence study revealed a different distribution of the inserts between human and food-associated isolates. The lin0464-lin0465 insert was predominantly found in food-associated strains of sequence type 121 (ST121). Functional characterization of this insert showed that the putative PfpI protease Lin0465 is involved in alkaline and oxidative stress responses but not in acidic, gastric, heat, cold, osmotic, and antibiotic stresses. In parallel, deletion of lin0464 decreased survival under alkaline and oxidative stresses. The expression of both genes increased significantly under oxidative stress conditions independently of the alternative sigma factor σ B Furthermore, we showed that the expression of the protease gene lin0465 is regulated by the transcription factor lin0464 under stress conditions, suggesting that lin0464 and lin0465 form a functional unit. In conclusion, we identified a novel stress survival islet 2 (SSI-2), predominantly present in L. monocytogenes ST121 strains, beneficial for survival under alkaline and oxidative stresses, potentially supporting adaptation and persistence of L. monocytogenes in food processing environments. IMPORTANCE Listeria monocytogenes strains of ST121 are known to persist for months and even years in food processing environments, thereby increasing the risk of food contamination and listeriosis. However, the molecular mechanism underlying this remarkable niche-specific adaptation

  7. Sustainable Facilities Management

    DEFF Research Database (Denmark)

    Nielsen, Susanne Balslev; Elle, Morten; Hoffmann, Birgitte

    2004-01-01

    The Danish public housing sector has more than 20 years of experience with sustainable facilities management based on user involvement. The paper outlines this development in a historical perspective and gives an analysis of different approaches to sustainable facilities management. The focus...... is on the housing departments and strateies for the management of the use of resources. The research methods used are case studies based on interviews in addition to literature studies. The paper explores lessons to be learned about sustainable facilities management in general, and points to a need for new...

  8. Standard Guide for Preparing Characterization Plans for Decommissioning Nuclear Facilities

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2009-01-01

    1.1 This standard guide applies to developing nuclear facility characterization plans to define the type, magnitude, location, and extent of radiological and chemical contamination within the facility to allow decommissioning planning. This guide amplifies guidance regarding facility characterization indicated in ASTM Standard E 1281 on Nuclear Facility Decommissioning Plans. This guide does not address the methodology necessary to release a facility or site for unconditional use. This guide specifically addresses: 1.1.1 the data quality objective for characterization as an initial step in decommissioning planning. 1.1.2 sampling methods, 1.1.3 the logic involved (statistical design) to ensure adequate characterization for decommissioning purposes; and 1.1.4 essential documentation of the characterization information. 1.2 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate saf...

  9. Nuclear facilities

    International Nuclear Information System (INIS)

    Anon.

    2002-01-01

    During September and October 2001, 15 events were recorded on the first grade and 1 on the second grade of the INES scale. The second grade event is in fact a re-classification of an incident that occurred on the second april 2001 at Dampierre power plant. This event happened during core refueling, a shift in the operation sequence led to the wrong positioning of 113 assemblies. A preliminary study of this event shows that this wrong positioning could have led, in other circumstances, to the ignition of nuclear reactions. Even in that case, the analysis made by EDF shows that the consequences on the staff would have been limited. Nevertheless a further study has shown that the existing measuring instruments could not have detected the power increase announcing the beginning of the chain reaction. The investigation has shown that there were deficiencies in the control of the successive operations involved in refueling. EDF has proposed a series of corrective measures to be implemented in all nuclear power plants. The other 15 events are described in the article. During this period 121 inspections have been made in nuclear facilities. (A.C.)

  10. New lethal disease involving type I and III collagen defect resembling geroderma osteodysplastica, De Barsy syndrome, and Ehlers-Danlos syndrome IV.

    OpenAIRE

    Jukkola, A; Kauppila, S; Risteli, L; Vuopala, K; Risteli, J; Leisti, J; Pajunen, L

    1998-01-01

    We describe the clinical findings and biochemical features of a male child suffering from a so far undescribed lethal connective tissue disorder characterised by extreme hypermobility of the joints, lax skin, cataracts, severe growth retardation, and insufficient production of type I and type III procollagens. His features are compared with Ehlers-Danlos type IV, De Barsy syndrome, and geroderma osteodysplastica, as these disorders show some symptoms and signs shared with our patient. The chi...

  11. Leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation is associated with cell-type-dependent splicing of mtAspRS mRNA

    NARCIS (Netherlands)

    van Berge, Laura; Dooves, Stephanie; van Berkel, Carola G. M.; Polder, Emiel; van der Knaap, Marjo S.; Scheper, Gert C.

    2012-01-01

    LBSL (leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation) is an autosomal recessive white matter disorder with slowly progressive cerebellar ataxia, spasticity and dorsal column dysfunction. Magnetic resonance imaging shows characteristic abnormalities in the

  12. A genome-wide search for genes involved in type 2 diabetes in a recently genetically isolated population from the Netherlands

    NARCIS (Netherlands)

    Y.S. Aulchenko (Yurii); N. Vaessen (Norbert); P. Heutink (Peter); J. Pullen (Jan); P.J.L.M. Snijders (Pieter); A. Hofman (Albert); L.A. Sandkuijl (Lodewijk); J.J. Houwing-Duistermaat (Jeanine); S. Bennett (Simon); B.A. Oostra (Ben); C.M. van Duijn (Cornelia); M. Edwards (Mark)

    2003-01-01

    textabstractMultiple genes, interacting with the environment, contribute to the susceptibility to type 2 diabetes. We performed a genome-wide search to localize type 2 diabetes susceptibility genes in a recently genetically isolated population in the Netherlands. We identified 79 nuclear families

  13. Decommissioning nuclear facilities

    International Nuclear Information System (INIS)

    Harmon, K.M.; Jenkins, C.E.; Waite, D.A.; Brooksbank, R.E.; Lunis, B.C.; Nemec, J.F.

    1976-01-01

    This paper describes the currently accepted alternatives for decommissioning retired light water reactor fuel cycle facilities and the current state of decommissioning technology. Three alternatives are recognized: Protective Storage; Entombment; and Dismantling. Application of these alternatives to the following types of facilities is briefly described: light water reactors; fuel reprocessing plants, and mixed oxide fuel fabrication plants. Brief descriptions are given of decommissioning operations and results at a number of sites, and recent studies of the future decommissioning of prototype fuel cycle facilities are reviewed. An overview is provided of the types of operations performed and tools used in common decontamination and decommissioning techniques and needs for improved technology are suggested. Planning for decommissioning a nuclear facility is dependent upon the maximum permitted levels of residual radioactive contamination. Proposed guides and recently developed methodology for development of site release criteria are reviewed. 21 fig, 32 references

  14. Male involvement in prevention of mother-to-child transmission of HIV in the context of partner testing in Goba town, Ethiopia: A facility-based cross-sectional study

    Directory of Open Access Journals (Sweden)

    M T Alemayehu

    2017-10-01

    Full Text Available Background. Antenatal care (ANC is an entry point for the prevention of mother-to-child transmission (PMTCT, particularly when a man accompanies his spouse for voluntary counselling and testing (VCT, even though this seldom happens in Ethiopia. Objective. To study the role of male partners in improving PMTCT/ANC, which is essential to prevent HIV/AIDS transmission in this country. Our study focused on identifying barriers for the low involvement in PMTCT/ANC among male partners whose spouses received ANC. Methods. A total of 422 male partners in Goba town, Oromia regional state, Ethiopia, were recruited in September - October 2014 and enrolled by a systematic sampling method. A facility-based cross-sectional study and two focus group discussions (FGDs were conducted. Binary logistic regression and odds ratios were calculated to ascertain sociodemographic and other important information compared with the outcome variable and PMTCT/ANC, while the findings of the FGDs were grouped according to the emerging themes and analysed manually by means of a thematic approach. Results. The percentage of male partners (22.7% accompanying their spouses for HIV testing and counselling at antenatal clinics improved three-fold when an invitation letter was introduced as a new initiative to increase male participation. Individuals in the age group 15 - 29 years (adjusted odds ratio (AOR 5.4, 95% confidence interval (CI 1.66 - 17.85, and whose duration of marriage was ˂5 years (AOR 5.6, 95% CI 1.83 - 17.30, were more likely to be tested than their referent groups. Men without a higher education (AOR 0.1, 95% CI 0.02 - 0.50, who disagreed with legal enforcement (AOR 0.1, 95% CI 0.07 - 0.32, were less likely to be tested, while those who did not notify their partners (AOR 8.4, 95% CI 1.92 - 37.12 were more likely to use the service. Being busy, proxy testing, fears of testing HIV-positive, neglecting the importance of VCT, and inadequate knowledge about the PMTCT

  15. Male involvement in prevention of mother-to-child transmission of HIV in the context of partner testing in Goba town, Ethiopia: A facility-based cross-sectional study.

    Science.gov (United States)

    Alemayehu, M T; Haidar, J

    2017-09-22

    Antenatal care (ANC) is an entry point for the prevention of mother-to-child transmission (PMTCT), particularly when a man accompanies his spouse for voluntary counselling and testing (VCT), even though this seldom happens in Ethiopia. To study the role of male partners in improving PMTCT/ANC, which is essential to prevent HIV/AIDS transmission in this country. Our study focused on identifying barriers for the low involvement in PMTCT/ANC among male partners whose spouses received ANC. A total of 422 male partners in Goba town, Oromia regional state, Ethiopia, were recruited in September - October 2014 and enrolled by a systematic sampling method. A facility-based cross-sectional study and two focus group discussions (FGDs) were conducted. Binary logistic regression and odds ratios were calculated to ascertain sociodemographic and other important information compared with the outcome variable and PMTCT/ANC, while the findings of the FGDs were grouped according to the emerging themes and analysed manually by means of a thematic approach. The percentage of male partners (22.7%) accompanying their spouses for HIV testing and counselling at antenatal clinics improved three-fold when an invitation letter was introduced as a new initiative to increase male participation. Individuals in the age group 15 - 29 years (adjusted odds ratio (AOR) 5.4, 95% confidence interval (CI) 1.66 - 17.85), and whose duration of marriage was ˂5 years (AOR 5.6, 95% CI 1.83 - 17.30), were more likely to be tested than their referent groups. Men without a higher education (AOR 0.1, 95% CI 0.02 - 0.50), who disagreed with legal enforcement (AOR 0.1, 95% CI 0.07 - 0.32), were less likely to be tested, while those who did not notify their partners (AOR 8.4, 95% CI 1.92 - 37.12) were more likely to use the service. Being busy, proxy testing, fears of testing HIV-positive, neglecting the importance of VCT, and inadequate knowledge about the PMTCT/ANC programme were other barriers that came to the

  16. Considerations about the licensing process of special nuclear industrial facilities

    Energy Technology Data Exchange (ETDEWEB)

    Talarico, M.A., E-mail: talaricomarco@hotmail.com [Marinha do Brasil, Rio de Janeiro, RJ (Brazil). Coordenacao do Porgrama de Submarino com Propulsao Nuclear; Melo, P.F. Frutuoso e [Coordenacao dos Programas de Pos-Graduacao em Engenharia (COPPE/UFRJ), Rio de Janeiro, RJ (Brazil). Programa de Engenharia Nuclear

    2015-07-01

    This paper brings a discussion about the challenges involved in the development of a new kind of nuclear facility in Brazil, a naval base for nuclear submarines, with attention to the licensing process and considerations about the risk-informed decision making application to the licensing process. Initially, a model of such a naval base, called in this work, special industrial facility, is proposed, with its systems and respective sets of basic requirements, in order to make it possible the accomplishment of the special industrial facility support function to the nuclear submarine. A discussion about current challenges to overcome in this project is presented: the challenges due to the new characteristics of this type of nuclear facility; existence of several interfaces between the special industrial facilities systems and nuclear submarine systems in design activities; lack of specific regulation in Brazil to allow the licensing process of special industrial facilities by the nuclear safety authority; and comments about the lack of information from reference nuclear facilities, as is the case with nuclear power reactors (for example, the German Grafenrheinfeld nuclear plant is the reference plant for the Brazilian Angra 2 nuclear plant). Finally, in view of these challenges, an analysis method of special industrial facility operational scenarios to assist the licensing process is proposed. Also, considerations about the application of risk-informed decision making to the special industrial facility activity and licensing process in Brazil are presented. (author)

  17. Considerations about the licensing process of special nuclear industrial facilities

    International Nuclear Information System (INIS)

    Talarico, M.A.; Melo, P.F. Frutuoso e

    2015-01-01

    This paper brings a discussion about the challenges involved in the development of a new kind of nuclear facility in Brazil, a naval base for nuclear submarines, with attention to the licensing process and considerations about the risk-informed decision making application to the licensing process. Initially, a model of such a naval base, called in this work, special industrial facility, is proposed, with its systems and respective sets of basic requirements, in order to make it possible the accomplishment of the special industrial facility support function to the nuclear submarine. A discussion about current challenges to overcome in this project is presented: the challenges due to the new characteristics of this type of nuclear facility; existence of several interfaces between the special industrial facilities systems and nuclear submarine systems in design activities; lack of specific regulation in Brazil to allow the licensing process of special industrial facilities by the nuclear safety authority; and comments about the lack of information from reference nuclear facilities, as is the case with nuclear power reactors (for example, the German Grafenrheinfeld nuclear plant is the reference plant for the Brazilian Angra 2 nuclear plant). Finally, in view of these challenges, an analysis method of special industrial facility operational scenarios to assist the licensing process is proposed. Also, considerations about the application of risk-informed decision making to the special industrial facility activity and licensing process in Brazil are presented. (author)

  18. Animal facilities

    International Nuclear Information System (INIS)

    Fritz, T.E.; Angerman, J.M.; Keenan, W.G.; Linsley, J.G.; Poole, C.M.; Sallese, A.; Simkins, R.C.; Tolle, D.

    1981-01-01

    The animal facilities in the Division are described. They consist of kennels, animal rooms, service areas, and technical areas (examining rooms, operating rooms, pathology labs, x-ray rooms, and 60 Co exposure facilities). The computer support facility is also described. The advent of the Conversational Monitor System at Argonne has launched a new effort to set up conversational computing and graphics software for users. The existing LS-11 data acquisition systems have been further enhanced and expanded. The divisional radiation facilities include a number of gamma, neutron, and x-ray radiation sources with accompanying areas for related equipment. There are five 60 Co irradiation facilities; a research reactor, Janus, is a source for fission-spectrum neutrons; two other neutron sources in the Chicago area are also available to the staff for cell biology studies. The electron microscope facilities are also described

  19. Reactor facility

    International Nuclear Information System (INIS)

    Suzuki, Hiroaki; Murase, Michio; Yokomizo, Osamu.

    1997-01-01

    The present invention provides a BWR type reactor facility capable of suppressing the amount of steams generated by the mutual effect of a failed reactor core and coolants upon occurrence of an imaginal accident, and not requiring spacial countermeasures for enhancing the pressure resistance of the container vessel. Namely, a means for supplying cooling water at a temperature not lower by 30degC than the saturated temperature corresponding to the inner pressure of the containing vessel upon occurrence of an accident is disposed to a lower dry well below the pressure vessel. As a result, upon occurrence of such an accident that the reactor core should be melted and flown downward of the pressure vessel, when cooling water at a temperature not lower than the saturated temperature, for example, cooling water at 100degC or higher is supplied to the lower dry well, abrupt generation of steams by the mutual effect of the failed reactor core and cooling water is scarcely caused compared with a case of supplying cooling water at a temperature lower than the saturation temperature by 30degC or more. Accordingly, the amount of steams to be generated can be suppressed, and special countermeasure is no more necessary for enhancing the pressure resistance of the container vessel is no more necessary. (I.S.)

  20. Impact of miglustat on evolution of atypical presentation of late-infantile-onset Niemann?Pick disease type C with early cognitive impairment, behavioral dysfunction, epilepsy, ophthalmoplegia, and cerebellar involvement: a case report

    OpenAIRE

    Cuisset, Jean-Marie; Sukno, S.; Trauffler, A.; Latour, P.; Dobbelaere, D.; Michaud, L.; Vall?e, L.

    2016-01-01

    Background Niemann?Pick disease type C is a rare inherited neurodegenerative disease involving impaired intracellular lipid trafficking and accumulation of glycolipids in various tissues, including the brain. Miglustat, a reversible inhibitor of glucosylceramide synthase, has been shown to be effective in the treatment of progressive neurological manifestations in pediatric and adult patients with Niemann?Pick disease type C, and has been used in that indication in Europe since 2010. Case pre...

  1. The type III secretion system is involved in the invasion and intracellular survival of Escherichia coli K1 in human brain microvascular endothelial cells

    OpenAIRE

    Yao, Yufeng; Xie, Yi; Perace, Donna; Zhong, Yi; Lu, Jie; Tao, Jing; Guo, Xiaokui; Kim, Kwang Sik

    2009-01-01

    Type III secretion systems have been documented in many Gram-negative bacteria, including enterohemorrhagic Escherichia coli. We have previously shown the existence of a putative type III secretion system in meningitis-causing E. coli K1 strains, referred to as E. coli type III secretion 2 (ETT2). The sequence of ETT2 in meningitis-causing E. coli K1 strain EC10 (O7:K1) revealed that ETT2 comprises the epr, epa and eiv genes, but bears mutations, deletions and insertions. We constructed the E...

  2. Environmental Monitoring, Water Quality - Water Pollution Control Facilities

    Data.gov (United States)

    NSGIC Education | GIS Inventory — A Water Pollution Control Facility is a DEP primary facility type related to the Water Pollution Control Program. The sub-facility types related to Water Pollution...

  3. Rare-earth organic frameworks involving three types of architecture tuned by the lanthanide contraction effect: hydrothermal syntheses, structures and luminescence.

    Science.gov (United States)

    Deng, Zhao-Peng; Kang, Wei; Huo, Li-Hua; Zhao, Hui; Gao, Shan

    2010-07-21

    The first example of rare-earth organic frameworks with 3-aminopyrazine-2-carboxylic acid (Hapca) was synthesized under hydrothermal conditions and characterized by elemental analysis, IR, PL, TG, powder and single-crystal X-ray diffraction. These ten complexes exhibit three different structure types with decreasing lanthanide radii: [La(apca)(3)](n) () for type I, {[Ln(apca)(ox)(H(2)O)(2)].H(2)O}(n) (Ln = Pr (2), Nd (3), ox = oxalate) for type II, and [Ln(2)(apca)(4)(OH)(2)(H(2)O)(2)](n) (Ln = Sm (4), Eu (5), Gd (6), Tb (7), Dy (8), Er (9), Y (10)) for type III. The structure of type I consists of 1D "snowflake" chains along a-axis, which are further interconnected by hydrogen bonds to produce a 3D sra net topology containing infinite (-C-O-La-)(n) rod-shaped SBU. Type II has 2D Ln-apca-ox 4(4)-net, in which a planar udud water tetramers (H(2)O)(4) are formed by coordinated and free water molecules. Type III also comprises of 2D 4(4)-layer network constructed from Ln-apca-OH. The structure diversity is mainly caused by the variation of coordinated ligand and lanthanide contraction effect. Remarkably, the oxalate in type II was in situ synthesized from 3-aminopyrazine-2-carboxylic acid through an oxidation-hydrolysis reaction. The luminescent investigations reveal that complex exhibits strong blue emission and complex exhibits characteristic luminescence of Eu(3+).

  4. Frequency of and Prognostic Significance of Cardiac Involvement at Presentation in Hereditary Transthyretin-Derived Amyloidosis and the Value of N-Terminal Pro-B-Type Natriuretic Peptide

    NARCIS (Netherlands)

    Klaassen, Sebastiaan H C; Tromp, Jasper; Nienhuis, Hans L A; van der Meer, Peter; van den Berg, Maarten P; Blokzijl, Hans; van Veldhuisen, Dirk J; Hazenberg, Bouke P C

    2018-01-01

    The aim of this study is to assess the prevalence of cardiac involvement in hereditary transthyretin-derived (ATTRm) amyloidosis at the time of diagnosis and to determine the diagnostic and clinical value of N-terminal pro-B-type natriuretic peptide (NT-proBNP). The University Medical Center

  5. Facilities Programming.

    Science.gov (United States)

    Bullis, Robert V.

    1992-01-01

    A procedure for physical facilities management written 17 years ago is still worth following today. Each of the steps outlined for planning, organizing, directing, controlling, and evaluating must be accomplished if school facilities are to be properly planned and constructed. However, lessons have been learned about energy consumption and proper…

  6. Parental involvement

    Directory of Open Access Journals (Sweden)

    Ezra S Simon

    2005-01-01

    Full Text Available Parent-Teacher Associations and other community groups can play a significant role in helping to establish and run refugee schools; their involvement can also help refugee adults adjust to their changed circumstances.

  7. Nuclear facilities

    International Nuclear Information System (INIS)

    Anon.

    2000-01-01

    Here is given the decree (2000-1065) of the 25. of October 2000 reporting the publication of the convention between the Government of the French Republic and the CERN concerning the safety of the LHC (Large Hadron Collider) and the SPS (Proton Supersynchrotron) facilities, signed in Geneva on July 11, 2000. By this convention, the CERN undertakes to ensure the safety of the LHC and SPS facilities and those of the operations of the LEP decommissioning. The French legislation and regulations on basic nuclear facilities (concerning more particularly the protection against ionizing radiations, the protection of the environment and the safety of facilities) and those which could be decided later on apply to the LHC, SPS and auxiliary facilities. (O.M.)

  8. Plasma Cell Type of Castleman's Disease Involving Renal Parenchyma and Sinus with Cardiac Tamponade: Case Report and Literature Review

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tae Un; Kim, Suk; Lee, Jun Woo; Lee, Nam Kyung; Jeon, Ung Bae; Ha, Hong Gu; Shin, Dong Hoon [Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan (Korea, Republic of)

    2012-09-15

    Castleman's disease is an uncommon disorder characterized by benign proliferation of the lymphoid tissue that occurs most commonly in the mediastinum. Although unusual locations and manifestations have been reported, involvement of the renal parenchyma and sinus, and moreover, manifestations as cardiac tamponade are extremely rare. Here, we present a rare case of Castleman's disease in the renal parenchyma and sinus that also accompanied cardiac tamponade.

  9. More than teacher directed or child initiated: Preschool curriculum type, parent involvement, and children's outcomes in the child-parent centers.

    Directory of Open Access Journals (Sweden)

    Elizabeth Graue

    2004-12-01

    Full Text Available This study investigated the contributions of curriculum approach and parent involvement to the short- and long-term effects of preschool participation in the Title I Chicago Child-Parent Centers. Data came from the complete cohort of 989 low-income children (93% African American in the Chicago Longitudinal Study, who attended preschool in the 20 Child-Parent Centers in 1983-1985 and kindergarten in 1985-1986. We found that implementation of an instructional approach rated high by Head Teachers in teacher-directed and child-initiated activities was most consistently associated with children’s outcomes, including school readiness at kindergarten entry, reading achievement in third and eighth grades, and avoidance of grade retention. Parent involvement in school activities, as rated by teachers and by parents, was independently associated with child outcomes from school readiness at kindergarten entry to eighth grade reading achievement and grade retention above and beyond the influence of curriculum approach. Findings indicate that instructional approaches that blend a teacher-directed focus with child-initiated activities and parental school involvement are origins of the long-term effects of participation in the Child-Parent Centers.

  10. Phenotypic analyses of Arabidopsis T-DNA insertion lines and expression profiling reveal that multiple L-type lectin receptor kinases are involved in plant immunity

    NARCIS (Netherlands)

    Wang, Y.; Bouwmeester, K.; Beseh, P.; Shan, W.; Govers, F.

    2014-01-01

    L-type lectin receptor kinases (LecRKs) are membrane-spanning receptor-like kinases with putative roles in biotic and abiotic stress responses and in plant development. In Arabidopsis, 45 LecRKs were identified but their functions are largely unknown. Here, a systematic functional analysis was

  11. Genome-Wide High-Throughput Screening to Investigate Essential Genes Involved in Methicillin-Resistant Staphylococcus aureus Sequence Type 398 Survival

    DEFF Research Database (Denmark)

    Christiansen, Mette Theilgaard; Kaas, Rolf Sommer; Chaudhuri, Roy R.

    2014-01-01

    Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) Sequence Type 398 (ST398) is an opportunistic pathogen that is able to colonize and cause disease in several animal species including humans. To better understand the adaptation, evolution, transmission and pathogenic...

  12. C3HC4-type RING finger protein NbZFP1 is involved in growth and fruit development in Nicotiana benthamiana.

    Directory of Open Access Journals (Sweden)

    Wenxian Wu

    Full Text Available C3HC4-type RING finger proteins constitute a large family in the plant kingdom and play important roles in various physiological processes of plant life. In this study, a C3HC4-type zinc finger gene was isolated from Nicotiana benthamiana. Sequence analysis indicated that the gene encodes a 24-kDa protein with 191 amino acids containing one typical C3HC4-type zinc finger domain; this gene was named NbZFP1. Transient expression of pGDG-NbZFP1 demonstrated that NbZFP1 was localized to the chloroplast, especially in the chloroplasts of cells surrounding leaf stomata. Virus-induced gene silencing (VIGS analysis indicated that silencing of NbZFP1 hampered fruit development, although the height of the plants was normal. An overexpression construct was then designed and transferred into Nicotiana benthamiana, and PCR and Southern blot showed that the NbZFP1 gene was successfully integrated into the Nicotiana benthamiana genome. The transgenic lines showed typical compactness, with a short internode length and sturdy stems. This is the first report describing the function of a C3HC4-type RING finger protein in tobacco.

  13. Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells

    Directory of Open Access Journals (Sweden)

    Atsushi Kaneko

    2013-01-01

    Full Text Available Purpose. Crohn's disease (CD and ulcerative colitis (UC, the two major forms of inflammatory bowel disease (IBD, have histopathologically and immunologically different characteristics. We previously reported that a traditional Japanese medicine, daikenchuto (TU-100, ameliorated a trinitrobenzenesulfonic acid- (TNBS- induced type-1 model colitis exhibiting histopathological features of CD through adrenomedullin (ADM enhancement. Our current aims were to examine whether TU-100 ameliorates a type-2 model colitis that histologically resembles UC and identify the active ingredients. Methods. TU-100 was administered orally to mice with oxazolone- (OXN- induced type-2 model colitis. The morbidity was evaluated by body weight loss and the macroscopic score of colonic lesions. ADM was quantified using an EIA kit. Results. TU-100 prevented weight loss and colon ulceration. ADM production by intestinal epithelial cells was increased by TU-100 addition. Screening to identify active ingredients showed that [6]-shogaol and hydroxy α-sanshool enhanced ADM production. Conclusions. TU-100 exerted a protective effect in OXN-induced type-2 model colitis, indicating that TU-100 may be a beneficial agent for treatment of UC.

  14. New lethal disease involving type I and III collagen defect resembling geroderma osteodysplastica, De Barsy syndrome, and Ehlers-Danlos syndrome IV.

    Science.gov (United States)

    Jukkola, A; Kauppila, S; Risteli, L; Vuopala, K; Risteli, J; Leisti, J; Pajunen, L

    1998-06-01

    We describe the clinical findings and biochemical features of a male child suffering from a so far undescribed lethal connective tissue disorder characterised by extreme hypermobility of the joints, lax skin, cataracts, severe growth retardation, and insufficient production of type I and type III procollagens. His features are compared with Ehlers-Danlos type IV, De Barsy syndrome, and geroderma osteodysplastica, as these disorders show some symptoms and signs shared with our patient. The child died because of failure of the connective tissue structures joining the skull and the spine, leading to progressive spinal stenosis. The aortic valve was translucent and insufficient. The clinical symptoms and signs, together with histological findings, suggested a collagen defect. Studies on both skin fibroblast cultures and the patient's serum showed reduced synthesis of collagen types I and III at the protein and RNA levels. The sizes of the mRNAs and newly synthesised proteins were normal, excluding gross structural abnormalities. These findings are not in accordance with any other collagen defect characterised so far.

  15. 30 CFR 57.6161 - Auxiliary facilities.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Auxiliary facilities. 57.6161 Section 57.6161...-Underground Only § 57.6161 Auxiliary facilities. (a) Auxiliary facilities used to store explosive material near work places shall be wooden, box-type containers equipped with covers or doors, or facilities...

  16. An Approach to Safeguards by Design (SBD) for Fuel Cycle Facilities

    International Nuclear Information System (INIS)

    Sankaran Nair, P.; Gangotra, S.; Karanam, R.

    2015-01-01

    Implementation of safeguards in bulk handling facilities such as fuel fabrication facilities and reprocessing facilities are a challenging task. This is attributed to the nuclear material present in the facility in the form of powder, pellet, green pellet, solution and gaseous. Additionally material hold up, material unaccounted for (MUF) and the operations carried out round the clock add to the difficulties in implementing safeguards. In facilities already designed or commissioned or operational, implementation of safeguards measures are relatively difficult. The authors have studied a number of measures which can be adopted at the design stage itself. Safeguard By Design (SBD) measures can help in more effective implementation of safeguards, reduction of cost and reduction in radiological dose to the installation personnel. The SBD measures in the power reactors are comparatively easier to implement than in the fuel fabrication plants, since reactors are item counting facilities while the fuel fabrication plants are bulk handling type of facilities and involves much rigorous nuclear material accounting methodology. The safeguards measures include technical measures like dynamic nuclear material accounting, near real time monitoring, remote monitoring, use of automation, facility imagery, Radio Frequency Identification (RFID) tagging, reduction of MUF in bulk handling facilities etc. These measures have been studied in the context of bulk handling facilities and presented in this paper. Incorporation of these measures at the design stage (SBD) is expected to improve the efficiency of safeguardability in such bulk handling and item counting facilities and proliferation resistance of nuclear material handled in such facilities. (author)

  17. A LysR-Type Transcriptional Regulator, RovM, Senses Nutritional Cues Suggesting that It Is Involved in Metabolic Adaptation of Yersinia pestis to the Flea Gut.

    Directory of Open Access Journals (Sweden)

    Viveka Vadyvaloo

    Full Text Available Yersinia pestis has evolved as a clonal variant of Yersinia pseudotuberculosis to cause flea-borne biofilm-mediated transmission of the bubonic plague. The LysR-type transcriptional regulator, RovM, is highly induced only during Y. pestis infection of the flea host. RovM homologs in other pathogens regulate biofilm formation, nutrient sensing, and virulence; including in Y. pseudotuberculosis, where RovM represses the major virulence factor, RovA. Here the role that RovM plays during flea infection was investigated using a Y. pestis KIM6+ strain deleted of rovM, ΔrovM. The ΔrovM mutant strain was not affected in characteristic biofilm gut blockage, growth, or survival during single infection of fleas. Nonetheless, during a co-infection of fleas, the ΔrovM mutant exhibited a significant competitive fitness defect relative to the wild type strain. This competitive fitness defect was restored as a fitness advantage relative to the wild type in a ΔrovM mutant complemented in trans to over-express rovM. Consistent with this, Y. pestis strains, producing elevated transcriptional levels of rovM, displayed higher growth rates, and differential ability to form biofilm in response to specific nutrients in comparison to the wild type. In addition, we demonstrated that rovA was not repressed by RovM in fleas, but that elevated transcriptional levels of rovM in vitro correlated with repression of rovA under specific nutritional conditions. Collectively, these findings suggest that RovM likely senses specific nutrient cues in the flea gut environment, and accordingly directs metabolic adaptation to enhance flea gut colonization by Y. pestis.

  18. F-Type Lectins: A Highly Diversified Family of Fucose-Binding Proteins with a Unique Sequence Motif and Structural Fold, Involved in Self/Non-Self-Recognition

    Directory of Open Access Journals (Sweden)

    Gerardo R. Vasta

    2017-11-01

    Full Text Available The F-type lectin (FTL family is one of the most recent to be identified and structurally characterized. Members of the FTL family are characterized by a fucose recognition domain [F-type lectin domain (FTLD] that displays a novel jellyroll fold (“F-type” fold and unique carbohydrate- and calcium-binding sequence motifs. This novel lectin family comprises widely distributed proteins exhibiting single, double, or greater multiples of the FTLD, either tandemly arrayed or combined with other structurally and functionally distinct domains, yielding lectin subunits of pleiotropic properties even within a single species. Furthermore, the extraordinary variability of FTL sequences (isoforms that are expressed in a single individual has revealed genetic mechanisms of diversification in ligand recognition that are unique to FTLs. Functions of FTLs in self/non-self-recognition include innate immunity, fertilization, microbial adhesion, and pathogenesis, among others. In addition, although the F-type fold is distinctive for FTLs, a structure-based search revealed apparently unrelated proteins with minor sequence similarity to FTLs that displayed the FTLD fold. In general, the phylogenetic analysis of FTLD sequences from viruses to mammals reveals clades that are consistent with the currently accepted taxonomy of extant species. However, the surprisingly discontinuous distribution of FTLDs within each taxonomic category suggests not only an extensive structural/functional diversification of the FTLs along evolutionary lineages but also that this intriguing lectin family has been subject to frequent gene duplication, secondary loss, lateral transfer, and functional co-option.

  19. Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN.

    Science.gov (United States)

    Montoya, Maria; Edwards, Matthew J; Reid, Delyth M; Borrow, Persephone

    2005-02-15

    In this study, we report the dynamic changes in activation and functions that occur in spleen dendritic cell (sDC) subsets following infection of mice with a natural murine pathogen, lymphocytic choriomeningitis virus (LCMV). Within 24 h postinfection (pi), sDCs acquired the ability to stimulate naive LCMV-specific CD8+ T cells ex vivo. Conventional (CD11chigh CD8+ and CD4+) sDC subsets rapidly up-regulated expression of costimulatory molecules and began to produce proinflammatory cytokines. Their tendency to undergo apoptosis ex vivo simultaneously increased, and in vivo the number of conventional DCs in the spleen decreased markedly, dropping approximately 2-fold by day 3 pi. Conversely, the number of plasmacytoid (CD11clowB220+) DCs in the spleen increased, so that they constituted almost 40% of sDCs by day 3 pi. Type 1 IFN production was up-regulated in plasmacytoid DCs by 24 h pi. Analysis of DC activation and maturation in mice unable to respond to type 1 IFNs implicated these cytokines in driving infection-associated phenotypic activation of conventional DCs and their enhanced tendency to undergo apoptosis, but also indicated the existence of type 1 IFN-independent pathways for the functional maturation of DCs during LCMV infection.

  20. Mammography Facilities

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Mammography Facility Database is updated periodically based on information received from the four FDA-approved accreditation bodies: the American College of...

  1. Canyon Facilities

    Data.gov (United States)

    Federal Laboratory Consortium — B Plant, T Plant, U Plant, PUREX, and REDOX (see their links) are the five facilities at Hanford where the original objective was plutonium removal from the uranium...

  2. A type 2C protein phosphatase FgPtc3 is involved in cell wall integrity, lipid metabolism, and virulence in Fusarium graminearum.

    Directory of Open Access Journals (Sweden)

    Jinhua Jiang

    Full Text Available Type 2C protein phosphatases (PP2Cs play important roles in regulating many biological processes in eukaryotes. Currently, little is known about functions of PP2Cs in filamentous fungi. The causal agent of wheat head blight, Fusarium graminearum, contains seven putative PP2C genes, FgPTC1, -3, -5, -5R, -6, -7 and -7R. In order to investigate roles of these PP2Cs, we constructed deletion mutants for all seven PP2C genes in this study. The FgPTC3 deletion mutant (ΔFgPtc3-8 exhibited reduced aerial hyphae formation and deoxynivalenol (DON production, but increased production of conidia. The mutant showed increased resistance to osmotic stress and cell wall-damaging agents on potato dextrose agar plates. Pathogencity assays showed that ΔFgPtc3-8 is unable to infect flowering wheat head. All of the defects were restored when ΔFgPtc3-8 was complemented with the wild-type FgPTC3 gene. Additionally, the FgPTC3 partially rescued growth defect of a yeast PTC1 deletion mutant under various stress conditions. Ultrastructural and histochemical analyses showed that conidia of ΔFgPtc3-8 contained an unusually high number of large lipid droplets. Furthermore, the mutant accumulated a higher basal level of glycerol than the wild-type progenitor. Quantitative real-time PCR assays showed that basal expression of FgOS2, FgSLT2 and FgMKK1 in the mutant was significantly higher than that in the wild-type strain. Serial analysis of gene expression in ΔFgPtc3-8 revealed that FgPTC3 is associated with various metabolic pathways. In contrast to the FgPTC3 mutant, the deletion mutants of FgPTC1, FgPTC5, FgPTC5R, FgPTC6, FgPTC7 or FgPTC7R did not show aberrant phenotypic features when grown on PDA medium or inoculated on wheat head. These results indicate FgPtc3 is the key PP2C that plays a critical role in a variety of cellular and biological functions, including cell wall integrity, lipid and secondary metabolisms, and virulence in F. graminearum.

  3. The study of the container types used for transport and final disposal of the radioactive wastes resulting from decommissioning of nuclear facilities

    International Nuclear Information System (INIS)

    Postelnicu, C.

    1998-01-01

    The purpose of the present paper is to select from a variety of package forms and capacities some containers which will be used for transport and disposal of the radioactive wastes resulting from decommissioning of nuclear facilities into the National Repository for Radioactive Waste - Baita, Bihor county. Taken into account the possibilities of railway and / or road transport and waste disposal in our country, detailed container classification was given in order to use them for radioactive waste transport and final disposal from decommissioning of IFIN-HH Research Reactor. (author)

  4. Biochemical evaluation of interactions between synergistic molecules and phase I enzymes involved in insecticide resistance in B- and Q-type Bemisia tabaci (Hemiptera: Aleyrodidae).

    Science.gov (United States)

    Panini, Michela; Tozzi, Francesco; Zimmer, Christoph T; Bass, Chris; Field, Linda; Borzatta, Valerio; Mazzoni, Emanuele; Moores, Graham

    2017-09-01

    Metabolic resistance is an important consideration in the whitefly Bemisia tabaci, where an esterase-based mechanism has been attributed to pyrethroid resistance and over-expression of the cytochrome P450, CYP6CM1, has been correlated to resistance to imidacloprid and other neonicotinoids. In vitro interactions between putative synergists and CYP6CM1, B and Q-type esterases were investigated, and structure-activity relationship analyses allowed the identification of chemical structures capable of acting as inhibitors of esterase and oxidase activities. Specifically, methylenedioxyphenyl (MDP) moieties with a polyether chain were preferable for optimum inhibition of B-type esterase, whilst corresponding dihydrobenzofuran structures were potent for the Q-esterase variation. Potent inhibition of CYP6CM1 resulted from structures which contained an alkynyl chain with a terminal methyl group. Synergist candidates could be considered for field control of B. tabaci, especially to abrogate neonicotinoid resistance. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  5. The lamellae-free-type pseudobranch of the euryhaline milkfish (Chanos chanos) is a Na(+), K(+)-ATPase-abundant organ involved in hypoosmoregulation.

    Science.gov (United States)

    Yang, Sheng-Hui; Kang, Chao-Kai; Kung, Hsiu-Ni; Lee, Tsung-Han

    2014-04-01

    In teleosts, the pseudobranch is hemibranchial, with a gill-like structure located near the first gill. We hypothesized that the pseudobranch of the milkfish might exhibit osmoregulatory ability similar to that of the gills. In this study, the obtained Na(+), K(+)-ATPase (NKA) activity and protein abundance profiles showed that these parameters were higher in the pseudobranchs of the seawater (SW)- than the freshwater (FW)-acclimated milkfish, opposite the situation in the gills. The pseudobranch of the milkfish contained two types of NKA-immunoreactive cells, chloride cells (CCs) and pseudobranch-type cells (PSCs). To further clarify the roles of CCs and PSCs in the pseudobranch, we investigated the distributions of two ion transporters: the Na(+), K(+), 2Cl(-) cotransporter (NKCC) and the cystic fibrosis transmembrane conductance regulator (CFTR). NKCC on the basolateral membrane and CFTR on the apical membrane were found only in pseudobranchial CCs of SW-acclimated individuals. Taken together, the results distinguished NKA-IR CCs and PSCs in the pseudobranch of milkfish using antibodies against NKCC and CFTR as markers. In addition, increases in the numbers and sizes of CCs as well as in NKA expression observed upon salinity challenge indicated the potential roles of pseudobranchs in hypo-osmoregulation in this euryhaline teleost. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Facility effluent monitoring plan for the fast flux test facility

    International Nuclear Information System (INIS)

    Nickels, J.M.; Dahl, N.R.

    1992-11-01

    A facility effluent monitoring plan is required by the US Department of Energy in US Department of Energy Order 5400.1 for any operations that involve hazardous materials and radioactive substances that could affect employee or public safety or the environment. A Facility Effluent Monitoring Plan determination was performed during calendar year 1991 and the evaluation requires the need for a facility effluent monitoring plan. This facility effluent monitoring plan assesses effluent monitoring systems and evaluates whether they are adequate to ensure the public health and safety as specified in applicable federal, state, and local requirements

  7. Applications of microtron facility

    International Nuclear Information System (INIS)

    Sanjeev, Ganesh

    2013-01-01

    An 8 MeV Microtron accelerator installed and commissioned in Mangalore University to strengthen research activities in the area of Radiation Physics and allied sciences is also being used extensively for coordinated research programs in basic and applied areas of science and technology involving researchers from national laboratories and sister universities of the region. The electron accelerator with its versatile features extends energetic electrons, intense photons and neutrons of moderate flux to cater to the needs of the users of the facility. A brief view of this 'first of its kind' facility in the country and the R and D programs with some sample results is presented. (author)

  8. Next generation storage facility

    International Nuclear Information System (INIS)

    Schlesser, J.A.

    1994-01-01

    With diminishing requirements for plutonium, a substantial quantity of this material requires special handling and ultimately, long-term storage. To meet this objective, we at Los Alamos, have been involved in the design of a storage facility with the goal of providing storage capabilities for this and other nuclear materials. This paper presents preliminary basic design data, not for the structure and physical plant, but for the container and arrays which might be configured within the facility, with strong emphasis on criticality safety features

  9. Venom of the Peruvian snake Bothriopsis oligolepis: Detection of antibacterial activity and involvement of proteolytic enzymes and C-type lectins in growth inhibition of Staphylococcus aureus.

    Science.gov (United States)

    Sulca, M A; Remuzgo, C; Cárdenas, J; Kiyota, S; Cheng, E; Bemquerer, M P; Machini, M T

    2017-08-01

    There is a rising interest in snake venoms proteins (SVPs) because these macromolecules are related to pharmacological properties that manifest themselves during poisoning and can lead to secondary microbial infections. Interestingly, researchers have somehow neglected the antimicrobial activity of SVPs. The aims of this study were: (i) to verify whether the venom of the Peruvian snake Bothriopsis oligolepis displays such activity; (ii) to isolate and identify some of its antimicrobial constituents. Liquid growth inhibition assays revealed that the crude venom inhibited the growth of Gram-positive and Gram-negative bacteria, but not of Candida species. Fractionation of the venom by anion-exchange chromatography provided fractions P2, P4 and P8 active against S. aureus. Fractionation of P2 or P8 by gel-filtration chromatography and of P4 by RP-HPLC furnished the sub-fractions P2-I, P8-II and P4-II, respectively, being those fractions active against S. aureus. Analyses of these sub-fractions by SDS-PAGE under denaturing/reducing conditions evidenced SVPs with 59-73, 27 and 14-28 kDa, respectively. Their in-gel tryptic digestion gave peptide fragments, whose sequencing by MALDI-TOF/MS followed by protein BLAST analysis allowed identifying PIII metalloprotease(s) [SVMP(s)] in P2-I, serine protease(s) [SVSP(s)] in P4-II and lectin(s) in P8-II. Detection of gelatinolytic activity in P2-I and P4-II reinforced the existence of PIII-SVMP(s) and SVSP(s), respectively. Activation of the coagulation cascade intrinsic pathway by P8-II (probably by interaction with factors IX and/or X as some snake C-type lectins do) supported the presence of C-type lectin(s). Altogether, these new findings reveal that the venom of the Peruvian snake Bothriopsis oligolepis displays antibacterial activity and that the isolated SVMP(s), SVSP(s) and C-type lectin(s) are associated to its ability to inhibit the growth of S. aureus. Copyright © 2017 Elsevier Ltd. All rights reserved.

  10. Genetic Variants Involved in Mitochondrial Oxidative Metabolism are associated with Type 2 Diabetes Mellitus in studies of 8,441 Danes

    DEFF Research Database (Denmark)

    Snogdal, Lena Sønder; Henriksen, Jan Erik; Beck-Nielsen, Henning

      Aims: Type 2 Diabetes (T2D) is characterized by insulin resistance and failure of the pancreatic beta cells to compensate for this defect. Several studies have demonstrated a link between insulin resistance and impaired mitochondrial oxidative phosphorylation (OxPhos) in skeletal muscle. Recently...... by the Diabetes Genetics Replication And Meta-analysis Consortium (DIAGRAM), we found that among 1284 SNPs in 119 OxPhos genes, 39 SNPs in 7 genes showed potential association with T2D (p0.8). One SNP...... a surrogate marker (BIG-AIR) for insulin secretion and variants in COX5B (rs11904110) and COX10 (rs10521253), and between fasting p-glucose and a variant in COX5B (rs11904110) and 2-h post-OGTT plasma glucose and a variant in NDUFV3 (rs8134542) (pgenetic variants...

  11. CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver.

    Directory of Open Access Journals (Sweden)

    Chih-Ya Yang

    Full Text Available CLEC4F, a member of C-type lectin, was first purified from rat liver extract with high binding affinity to fucose, galactose (Gal, N-acetylgalactosamine (GalNAc, and un-sialylated glucosphingolipids with GalNAc or Gal terminus. However, the biological functions of CLEC4F have not been elucidated. To address this question, we examined the expression and distribution of murine CLEC4F, determined its binding specificity by glycan array, and investigated its function using CLEC4F knockout (Clec4f-/- mice. We found that CLEC4F is a heavily glycosylated membrane protein co-expressed with F4/80 on Kupffer cells. In contrast to F4/80, CLEC4F is detectable in fetal livers at embryonic day 11.5 (E11.5 but not in yolk sac, suggesting the expression of CLEC4F is induced as cells migrate from yolk cells to the liver. Even though CLEC4F is not detectable in tissues outside liver, both residential Kupffer cells and infiltrating mononuclear cells surrounding liver abscesses are CLEC4F-positive upon Listeria monocytogenes (L. monocytogenes infection. While CLEC4F has strong binding to Gal and GalNAc, terminal fucosylation inhibits CLEC4F recognition to several glycans such as Fucosyl GM1, Globo H, Bb3∼4 and other fucosyl-glycans. Moreover, CLEC4F interacts with alpha-galactosylceramide (α-GalCer in a calcium-dependent manner and participates in the presentation of α-GalCer to natural killer T (NKT cells. This suggests that CLEC4F is a C-type lectin with diverse binding specificity expressed on residential Kupffer cells and infiltrating monocytes in the liver, and may play an important role to modulate glycolipids presentation on Kupffer cells.

  12. Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action.

    Directory of Open Access Journals (Sweden)

    Inês Barroso

    2003-10-01

    Full Text Available Type 2 diabetes is an increasingly common, serious metabolic disorder with a substantial inherited component. It is characterised by defects in both insulin secretion and action. Progress in identification of specific genetic variants predisposing to the disease has been limited. To complement ongoing positional cloning efforts, we have undertaken a large-scale candidate gene association study. We examined 152 SNPs in 71 candidate genes for association with diabetes status and related phenotypes in 2,134 Caucasians in a case-control study and an independent quantitative trait (QT cohort in the United Kingdom. Polymorphisms in five of 15 genes (33% encoding molecules known to primarily influence pancreatic beta-cell function-ABCC8 (sulphonylurea receptor, KCNJ11 (KIR6.2, SLC2A2 (GLUT2, HNF4A (HNF4alpha, and INS (insulin-significantly altered disease risk, and in three genes, the risk allele, haplotype, or both had a biologically consistent effect on a relevant physiological trait in the QT study. We examined 35 genes predicted to have their major influence on insulin action, and three (9%-INSR, PIK3R1, and SOS1-showed significant associations with diabetes. These results confirm the genetic complexity of Type 2 diabetes and provide evidence that common variants in genes influencing pancreatic beta-cell function may make a significant contribution to the inherited component of this disease. This study additionally demonstrates that the systematic examination of panels of biological candidate genes in large, well-characterised populations can be an effective complement to positional cloning approaches. The absence of large single-gene effects and the detection of multiple small effects accentuate the need for the study of larger populations in order to reliably identify the size of effect we now expect for complex diseases.

  13. Metals in proteins: correlation between the metal-ion type, coordination number and the amino-acid residues involved in the coordination.

    Science.gov (United States)

    Dokmanić, Ivan; Sikić, Mile; Tomić, Sanja

    2008-03-01

    Metal ions are constituents of many metalloproteins, in which they have either catalytic (metalloenzymes) or structural functions. In this work, the characteristics of various metals were studied (Cu, Zn, Mg, Mn, Fe, Co, Ni, Cd and Ca in proteins with known crystal structure) as well as the specificity of their environments. The analysis was performed on two data sets: the set of protein structures in the Protein Data Bank (PDB) determined with resolution metal ion and its electron donors and the latter was used to assess the preferred coordination numbers and common combinations of amino-acid residues in the neighbourhood of each metal. Although the metal ions considered predominantly had a valence of two, their preferred coordination number and the type of amino-acid residues that participate in the coordination differed significantly from one metal ion to the next. This study concentrates on finding the specificities of a metal-ion environment, namely the distribution of coordination numbers and the amino-acid residue types that frequently take part in coordination. Furthermore, the correlation between the coordination number and the occurrence of certain amino-acid residues (quartets and triplets) in a metal-ion coordination sphere was analysed. The results obtained are of particular value for the identification and modelling of metal-binding sites in protein structures derived by homology modelling. Knowledge of the geometry and characteristics of the metal-binding sites in metalloproteins of known function can help to more closely determine the biological activity of proteins of unknown function and to aid in design of proteins with specific affinity for certain metals.

  14. Development of radiation safety monitoring system at gamma greenhouse gamma facility

    International Nuclear Information System (INIS)

    Hairul Nizam Idris; Azimawati Ahmad, Ahmad Zaki Hussain; Ahmad Fairuz Mohd Nasir

    2009-01-01

    This paper is discussing about installation of radiation safety monitoring system at Gamma Greenhouse Gamma facility, Agrotechnology and Bioscience Division (BAB). This facility actually is an outdoor type irradiation facility, which first in Nuclear Malaysia and the only one in Malaysia. Source Cs-137 (801 Curie) was use as radiation source and it located at the centre of 30 metres diameter size of open irradiation area. The radiation measurement and monitoring system to be equipped in this facility were required the proper equipment and devices, specially purpose for application at outside of building. Research review, literature study and discussion with the equipment manufacturers was being carried out, in effort to identify the best system should be developed. Factors such as tropical climate, environment surrounding and security were considered during selecting the proper system. Since this facility involving with panoramic radiation type, several critical and strategic locations have been fixed with radiation detectors, up to the distance at 200 meter from the radiation source. Apart from that, this developed system also was built for capable to provide the online real-time reading (using internet). In general, it can be summarized that the radiation safety monitoring system for outdoor type irradiation facility was found much different and complex compared to the system for indoor type facility. Keyword: radiation monitoring, radiation safety, Gamma Greenhouse, outdoor irradiation facility, panoramic radiation. (Author)

  15. An Outbreak of Streptococcus pyogenes in a Mental Health Facility: Advantage of Well-Timed Whole-Genome Sequencing Over emm Typing.

    Science.gov (United States)

    Bergin, Sarah M; Periaswamy, Balamurugan; Barkham, Timothy; Chua, Hong Choon; Mok, Yee Ming; Fung, Daniel Shuen Sheng; Su, Alex Hsin Chuan; Lee, Yen Ling; Chua, Ming Lai Ivan; Ng, Poh Yong; Soon, Wei Jia Wendy; Chu, Collins Wenhan; Tan, Siyun Lucinda; Meehan, Mary; Ang, Brenda Sze Peng; Leo, Yee Sin; Holden, Matthew T G; De, Partha; Hsu, Li Yang; Chen, Swaine L; de Sessions, Paola Florez; Marimuthu, Kalisvar

    2018-05-09

    OBJECTIVEWe report the utility of whole-genome sequencing (WGS) conducted in a clinically relevant time frame (ie, sufficient for guiding management decision), in managing a Streptococcus pyogenes outbreak, and present a comparison of its performance with emm typing.SETTINGA 2,000-bed tertiary-care psychiatric hospital.METHODSActive surveillance was conducted to identify new cases of S. pyogenes. WGS guided targeted epidemiological investigations, and infection control measures were implemented. Single-nucleotide polymorphism (SNP)-based genome phylogeny, emm typing, and multilocus sequence typing (MLST) were performed. We compared the ability of WGS and emm typing to correctly identify person-to-person transmission and to guide the management of the outbreak.RESULTSThe study included 204 patients and 152 staff. We identified 35 patients and 2 staff members with S. pyogenes. WGS revealed polyclonal S. pyogenes infections with 3 genetically distinct phylogenetic clusters (C1-C3). Cluster C1 isolates were all emm type 4, sequence type 915 and had pairwise SNP differences of 0-5, which suggested recent person-to-person transmissions. Epidemiological investigation revealed that cluster C1 was mediated by dermal colonization and transmission of S. pyogenes in a male residential ward. Clusters C2 and C3 were genomically diverse, with pairwise SNP differences of 21-45 and 26-58, and emm 11 and mostly emm120, respectively. Clusters C2 and C3, which may have been considered person-to-person transmissions by emm typing, were shown by WGS to be unlikely by integrating pairwise SNP differences with epidemiology.CONCLUSIONSWGS had higher resolution than emm typing in identifying clusters with recent and ongoing person-to-person transmissions, which allowed implementation of targeted intervention to control the outbreak.Infect Control Hosp Epidemiol 2018;1-9.

  16. Involvement of skeletal renin-angiotensin system and kallikrein-kinin system in bone deteriorations of type 1 diabetic mice with estrogen deficiency.

    Science.gov (United States)

    Zhang, Yan; Wang, Liang; Liu, Jin-Xin; Wang, Xin-Luan; Shi, Qi; Wang, Yong-Jun

    This study was aimed to investigate the involvement of skeletal renin-angiotensin system (RAS) and kallikrein-kinin system (KKS) in bone deteriorations of mice in response to the combination treatment of estrogen deficiency and hyperglycemia. The female C57BL/6J mice were sham-operated or ovariectomized with vehicle or streptozotocin (STZ) treatment. Two weeks later, the biochemistries in serum and urine were determined by standard colorimetric methods or ELISA. The H&E and TRAP staining were performed at the tibial proximal metaphysis. The polymerase chain reaction and immunoblotting were applied for molecular analysis on mRNA and protein expression. The mice after treating with ovariectomy and STZ showed the decreased level of serum Ca and the increased level of serum PTH and urine Ca. The H&E staining showed trabecular bone abnormalities as demonstrated by the loss, disconnection and separation of trabecular bone network as well as the loss of chondrocytes and appearance of chondrocyte cluster at growth plate of tibia. The significant increase of matured osteoclast number was shown in group with double treatments. The combination treatment significantly up-regulated mRNA expression of AGT, ACE, renin receptor, MMP-9 and CAII, and protein expression of renin, and decreased the ratio of OPG/RANKL and the expression of bradykinin receptors in bone tissue. Ovariectomy combined with STZ induction produced more detrimental actions on bone through the activation of local bone RAS and the down-regulation of bradykinin receptors, as compared to the respective single treatment. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. Antibiotic treatment partially protects against type 1 diabetes in the Bio-Breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes?

    NARCIS (Netherlands)

    Brugman, S.; Klatter, F. A.; Visser, J. T. J.; Wildeboer-Veloo, A. C. M.; Harmsen, H. J. M.; Rozing, J.; Bos, N. A.

    Aims/hypothesis Accumulating data suggest that the gut immune system plays a role in the development of type 1 diabetes. The intestinal flora is essential for the development of the (gut) immune system and the establishment of tolerance. It has been reported that oral administration of food and

  18. COSPAS-SARSAT Beacon Certification Facility

    Data.gov (United States)

    Federal Laboratory Consortium — EPG's COSPAS-SARSAT Beacon Certification Facility is one of five certification facilities in the world. Formal certifications are available for all beacon types and...

  19. Possible involvement of the transient receptor potential vanilloid type 1 channel in postoperative adhesive obstruction and its prevention by a kampo (traditional Japanese) medicine, daikenchuto.

    Science.gov (United States)

    Tokita, Yohei; Yamamoto, Masahiro; Satoh, Kazuko; Nishiyama, Mitsue; Iizuka, Seiichi; Imamura, Sachiko; Kase, Yoshio

    2011-01-01

    This study focused on the localization of transient receptor potential vanilloid type 1 (TRPV1) in the intestines in postoperative adhesion model rats and investigated the underlying mechanism for the anti-adhesion action of daikenchuto (DKT), especially in relation to TRPV1. Postoperative intestinal adhesion was induced by sprinkling talc in the small intestine. The expression of TRPV1 mRNA was examined by in situ hybridization and real-time RT-PCR. The effects of DKT and its major ingredient, hydroxy sanshool, with or without ruthenium red, a TRP-channel antagonist, on talc-induced intestinal adhesions were evaluated. The level of TRPV1 mRNA was higher in the adhesion regions of talc-treated rats than in normal small intestine of sham-operated rats. Localization of TRPV1 mRNA expression was identified in the submucosal plexus of both sham-operated and talc-treated rats; and in talc-treated rats, it was observed also in the myenteric plexus and regions of adhesion. Capsaicin, DKT, and hydroxy sanshool significantly prevented formation of intestinal adhesions. The effects of DKT and hydroxy sanshool were abrogated by subcutaneous injection of ruthenium red. These results suggest that pharmacological modulation of TRPV1 might be a possible therapeutic option in postoperative intestinal adhesion, which might be relevant to the prevention of postoperative adhesive obstruction by DKT.

  20. Melanisation of Aspergillus terreus—Is Butyrolactone I Involved in the Regulation of Both DOPA and DHN Types of Pigments in Submerged Culture?

    Directory of Open Access Journals (Sweden)

    Elina K. Palonen

    2017-05-01

    Full Text Available Pigments and melanins of fungal spores have been investigated for decades, revealing important roles in the survival of the fungus in hostile environments. The key genes and the encoded enzymes for pigment and melanin biosynthesis have recently been found in Ascomycota, including Aspergillus spp. In Aspergillus terreus, the pigmentation has remained mysterious with only one class of melanin biogenesis being found. In this study, we examined an intriguing, partially annotated gene cluster of A. terreus strain NIH2624, utilizing previously sequenced transcriptome and improved gene expression data of strain MUCL 38669, under the influence of a suggested quorum sensing inducing metabolite, butyrolactone I. The core polyketide synthase (PKS gene of the cluster was predicted to be significantly longer on the basis of the obtained transcriptional data, and the surrounding cluster was positively regulated by butyrolactone I at the late growth phase of submerged culture, presumably during sporulation. Phylogenetic analysis of the extended PKS revealed remarkable similarity with a group of known pigments of Fusarium spp., indicating a similar function for this PKS. We present a hypothesis of this PKS cluster to biosynthesise a 1,8-dihydroxynaphthalene (DHN-type of pigment during sporulation with the influence of butyrolactone I under submerged culture.

  1. The Tudor domain protein Spindlin1 is involved in intrinsic antiviral defense against incoming hepatitis B Virus and herpes simplex virus type 1.

    Directory of Open Access Journals (Sweden)

    Aurélie Ducroux

    2014-09-01

    Full Text Available Hepatitis B virus infection (HBV is a major risk factor for the development of hepatocellular carcinoma. HBV replicates from a covalently closed circular DNA (cccDNA that remains as an episome within the nucleus of infected cells and serves as a template for the transcription of HBV RNAs. The regulatory protein HBx has been shown to be essential for cccDNA transcription in the context of infection. Here we identified Spindlin1, a cellular Tudor-domain protein, as an HBx interacting partner. We further demonstrated that Spindlin1 is recruited to the cccDNA and inhibits its transcription in the context of infection. Spindlin1 knockdown induced an increase in HBV transcription and in histone H4K4 trimethylation at the cccDNA, suggesting that Spindlin1 impacts on epigenetic regulation. Spindlin1-induced transcriptional inhibition was greater for the HBV virus deficient for the expression of HBx than for the HBV WT virus, suggesting that HBx counteracts Spindlin1 repression. Importantly, we showed that the repressive role of Spindlin1 is not limited to HBV transcription but also extends to other DNA virus that replicate within the nucleus such as Herpes Simplex Virus type 1 (HSV-1. Taken together our results identify Spindlin1 as a critical component of the intrinsic antiviral defense and shed new light on the function of HBx in HBV infection.

  2. Analgesic and anti-inflammatory activities of hydro-alcoholic extract of Lavandula officinalis in mice: possible involvement of the cyclooxygenase type 1 and 2 enzymes

    Directory of Open Access Journals (Sweden)

    Yasaman Husseini

    Full Text Available Abstract Lavandula officinalis Chaix, Lamiaceae, extracts can inhibit inflammation and also pain induced by formalin in mice. This study evaluated the effects of L. officinalis hydro-alcoholic extract on pain induced by formalin and also cyclooxygenase (COX type 1 and 2 activity in mice. To evaluate probable analgesic and anti-inflammatory effects of the extract, flowers were prepared by maceration and extraction in alcohol and their analgesic effects were studied in male mice, using formalin and hot plate tests. The effect of intraperitoneal hydro-alcoholic extracts of L. officinalis (100, 200, 250, 300, 400 and 800 mg/kg, subcutaneous morphine (10 mg/kg, dexamethasone (10 mg/kg; i.p. and indomethacin (10 mg/kg; i.p. on formalin induced pain were studied. Our results indicated that administration of the extract (100, 200, 250, 300, 400 and 800 mg/kg; i.p. has inhibitory effects on inflammation induced by formalin injection into the animals hind paw. Moreover, this inhibitory effect was equal to the effects of morphine, dexamethasone and indomethacin. The extract in100, 200 and 300 mg/kg; significantly reduced heat-induced pain. The extract also reduced COX activity in dose dependent manner, where the inhibitory effect on COX1 activity was 33% and on COX2 activity was 45%. Here for the first time we show that L. officinialis extract can modulate pain and inflammation induced by formalin by inhibition of COX enzymes.

  3. Molecular interactions involved in the transactivation of the human T-cell leukemia virus type 1 promoter mediated by Tax and CREB-2 (ATF-4).

    Science.gov (United States)

    Gachon, F; Thebault, S; Peleraux, A; Devaux, C; Mesnard, J M

    2000-05-01

    The human T-cell leukemia virus type 1 (HTLV-1) Tax protein activates viral transcription through three 21-bp repeats located in the U3 region of the HTLV-1 long terminal repeat and called Tax-responsive elements (TxREs). Each TxRE contains nucleotide sequences corresponding to imperfect cyclic AMP response elements (CRE). In this study, we demonstrate that the bZIP transcriptional factor CREB-2 is able to bind in vitro to the TxREs and that CREB-2 binding to each of the 21-bp motifs is enhanced by Tax. We also demonstrate that Tax can weakly interact with CREB-2 bound to a cellular palindromic CRE motif such as that found in the somatostatin promoter. Mutagenesis of Tax and CREB-2 demonstrates that both N- and C-terminal domains of Tax and the C-terminal region of CREB-2 are required for direct interaction between the two proteins. In addition, the Tax mutant M47, defective for HTLV-1 activation, is unable to form in vitro a ternary complex with CREB-2 and TxRE. In agreement with recent results suggesting that Tax can recruit the coactivator CREB-binding protein (CBP) on the HTLV-1 promoter, we provide evidence that Tax, CREB-2, and CBP are capable of cooperating to stimulate viral transcription. Taken together, our data highlight the major role played by CREB-2 in Tax-mediated transactivation.

  4. Identification and characterization of the Luc2-type luciferase in the Japanese firefly, Luciola parvula, involved in a dim luminescence in immobile stages.

    Science.gov (United States)

    Bessho-Uehara, Manabu; Oba, Yuichi

    2017-09-01

    Nocturnal Japanese fireflies, Luciola parvula, emit from their lanterns a yellow light, one of the most red-shifted colors found among fireflies. Previously, we isolated and characterized two different types of luciferase gene, Luc1 and Luc2, from the fireflies Luciola cruciata and Luciola lateralis; Luc1 is responsible for the green-yellow luminescence of larval and adult lanterns, whereas Luc2 is responsible for the dim greenish glow of eggs and pupal bodies. The biological role of firefly lanterns in adults is related to sexual communication, but why the eggs and pupae glow remains uncertain. In this study, we isolated the gene Luc2 from L. parvula, and compared its expression profiles and enzymatic characteristics with those of Luc1. A semi-quantitative reverse transcription polymerase chain reaction showed that Luc1 was predominantly expressed in larvae, prepupae, pupae and adults, whereas Luc2 was expressed in eggs, prepupae, pupae and adult females. Enzymatic analyses showed that the luminescent color of Luc1 matches the visual sensitivity of L. parvula eyes, whereas that of Luc2 is very different from it. These results suggest that the biological role of Luc2 expressed in immobile stages is not intraspecific communication. Copyright © 2017 John Wiley & Sons, Ltd.

  5. A facile enhancement in battery-type of capacitive performance of spinel NiCo2O4 nanostructure via directly tuning thermal decomposition temperature

    International Nuclear Information System (INIS)

    Jiang, Shu; Sun, Yujing; Dai, Haichao; Ni, Pengjuan; Lu, Wangdong; Wang, Yilin; Li, Zhen; Li, Zhuang

    2016-01-01

    A facile, low cost and time-saving method to synthesize porous NiCo 2 O 4 nanoplatelet and nanorod structures is developed via a simple two-step route. A flakes assembled precursor containing Ni-Co hydroxides is firstly prepared via a facile, low-cost chemical bath coprecipitation process only using diluted ammonia solution as a precipitant to govern over the nucleation, growth, and agglomeration processes.Then, porous NiCo 2 O 4 nanoplatelet and nanorod structures are successfully obtained through pyrolyzing the above precursor. The influence of the calcination temperature is mainly studied on the pyrolysis reaction. The calcination temperature has statistically significant effects on the morphology and structure evolution, crystallinity, electronic conductivity and the electrochemical performances of the products. The optimized, nanoplatelet predominated NiCo 2 O 4 spinel, calcinated at 300 ∘C for 6 h (denoted as NC300), has excellent crystallinity and electric conductivity. It shows a superior-specific capacitance of 1362F g −1 at a current density of 1 A g −1 .When the current density increases to 16 A g −1 , the specific capacity still retains 964 F g −1 (70.8% capacity retention). Ragone plot indicates maximum energy density of our porous NC300 electrode is 75.67 W h kg −1 at a power density of 499.82 W kg −1 . Cycle-life tests show that the specific capacitance of NC300 is nearly stable between 300 and 1500 cycles, indicating its potential use in energy-storage field.The simplicity and practicability of the modified pyrolysis process may facilitate the successful commercial applications in electrochemical capacitors for nanostructured NiCo 2 O 4 spinel.

  6. Effect of treatment with cyclophosphamide in low doses upon the onset of delayed type hypersensitivity in mice chronically infected with Trypanosoma cruzi: involvement of heart interstitial dendritic cells

    Directory of Open Access Journals (Sweden)

    Torriceli Souza The

    2013-09-01

    Full Text Available Acute infection with Trypanosoma cruzi results in intense myocarditis, which progresses to a chronic, asymptomatic indeterminate form. The evolution toward this chronic cardiac form occurs in approximately 30% of all cases of T. cruzi infection. Suppression of delayed type hypersensitivity (DTH has been proposed as a potential explanation of the indeterminate form. We investigated the effect of cyclophosphamide (CYCL treatment on the regulatory mechanism of DTH and the participation of heart interstitial dendritic cells (IDCs in this process using BALB/c mice chronically infected with T. cruzi. One group was treated with CYCL (20 mg/kg body weight for one month. A DTH skin test was performed by intradermal injection of T. cruzi antigen (3 mg/mL in the hind-footpad and measured the skin thickness after 24 h, 48 h and 72 h. The skin test revealed increased thickness in antigen-injected footpads, which was more evident in the mice treated with CYCL than in those mice that did not receive treatment. The thickened regions were characterised by perivascular infiltrates and areas of necrosis. Intense lesions of the myocardium were present in three/16 cases and included large areas of necrosis. Morphometric evaluation of lymphocytes showed a predominance of TCD8 cells. Heart IDCs were immunolabelled with specific antibodies (CD11b and CD11c and T. cruzi antigens were detected using a specific anti-T. cruzi antibody. Identification of T. cruzi antigens, sequestered in these cells using specific anti-T. cruzi antibodies was done, showing a significant increase in the number of these cells in treated mice. These results indicate that IDCs participate in the regulatory mechanisms of DTH response to T. cruzi infection.

  7. Cell-to-cell transformation in Escherichia coli: a novel type of natural transformation involving cell-derived DNA and a putative promoting pheromone.

    Directory of Open Access Journals (Sweden)

    Rika Etchuuya

    Full Text Available Escherichia coli is not assumed to be naturally transformable. However, several recent reports have shown that E. coli can express modest genetic competence in certain conditions that may arise in its environment. We have shown previously that spontaneous lateral transfer of non-conjugative plasmids occurs in a colony biofilm of mixed E. coli strains (a set of a donor strain harbouring a plasmid and a plasmid-free recipient strain. In this study, with high-frequency combinations of strains and a plasmid, we constructed the same lateral plasmid transfer system in liquid culture. Using this system, we demonstrated that this lateral plasmid transfer was DNase-sensitive, indicating that it is a kind of transformation in which DNase-accessible extracellular naked DNA is essential. However, this transformation did not occur with purified plasmid DNA and required a direct supply of plasmid from co-existing donor cells. Based on this feature, we have termed this transformation type as 'cell-to-cell transformation'. Analyses using medium conditioned with the high-frequency strain revealed that this strain released a certain factor(s that promoted cell-to-cell transformation and arrested growth of the other strains. This factor is heat-labile and protease-sensitive, and its roughly estimated molecular mass was between ∼9 kDa and ∼30 kDa, indicating that it is a polypeptide factor. Interestingly, this factor was effective even when the conditioned medium was diluted 10(-5-10(-6, suggesting that it acts like a pheromone with high bioactivity. Based on these results, we propose that cell-to-cell transformation is a novel natural transformation mechanism in E. coli that requires cell-derived DNA and is promoted by a peptide pheromone. This is the first evidence that suggests the existence of a peptide pheromone-regulated transformation mechanism in E. coli and in Gram-negative bacteria.

  8. Roles of Fukutin, the Gene Responsible for Fukuyama-Type Congenital Muscular Dystrophy, in Neurons: Possible Involvement in Synaptic Function and Neuronal Migration

    International Nuclear Information System (INIS)

    Hiroi, Atsuko; Yamamoto, Tomoko; Shibata, Noriyuki; Osawa, Makiko; Kobayashi, Makio

    2011-01-01

    Fukutin is a gene responsible for Fukuyama-type congenital muscular dystrophy (FCMD), accompanying ocular and brain malformations represented by cobblestone lissencephaly. Fukutin is related to basement membrane formation via the glycosylation of α-dystoglycan (α-DG), and astrocytes play a crucial role in the pathogenesis of the brain lesion. On the other hand, its precise function in neurons is unknown. In this experiment, the roles of fukutin in mature and immature neurons were examined using brains from control subjects and FCMD patients and cultured neuronal cell lines. In quantitative PCR, the expression level of fukutin looked different depending on the region of the brain examined. A similar tendency in DG expression appears to indicate a relation between fukutin and α-DG in mature neurons. An increase of DG mRNA and core α-DG in the FCMD cerebrum also supports the relation. In immunohistochemistry, dot-like positive reactions for VIA4-1, one of the antibodies detecting the glycosylated α-DG, in Purkinje cells suggest that fukutin is related to at least a post-synaptic function via the glycosylation of α-DG. As for immature neurons, VIA4-1 was predominantly positive in cells before and during migration with expression of fukutin, which suggest a participation of fukutin in neuronal migration via the glycosylation of α-DG. Moreover, fukutin may prevent neuronal differentiation, because its expression was significantly lower in the adult cerebrum and in differentiated cultured cells. A knockdown of fukutin was considered to induce differentiation in cultured cells. Fukutin seems to be necessary to keep migrating neurons immature during migration, and also to support migration via α-DG

  9. Inhibition of cancer cell growth by exposure to a specific time-varying electromagnetic field involves T-type calcium channels.

    Directory of Open Access Journals (Sweden)

    Carly A Buckner

    Full Text Available Electromagnetic field (EMF exposures affect many biological systems. The reproducibility of these effects is related to the intensity, duration, frequency, and pattern of the EMF. We have shown that exposure to a specific time-varying EMF can inhibit the growth of malignant cells. Thomas-EMF is a low-intensity, frequency-modulated (25-6 Hz EMF pattern. Daily, 1 h, exposures to Thomas-EMF inhibited the growth of malignant cell lines including B16-BL6, MDA-MB-231, MCF-7, and HeLa cells but did not affect the growth of non-malignant cells. Thomas-EMF also inhibited B16-BL6 cell proliferation in vivo. B16-BL6 cells implanted in syngeneic C57b mice and exposed daily to Thomas-EMF produced smaller tumours than in sham-treated controls. In vitro studies showed that exposure of malignant cells to Thomas-EMF for > 15 min promoted Ca(2+ influx which could be blocked by inhibitors of voltage-gated T-type Ca(2+ channels. Blocking Ca(2+ uptake also blocked Thomas-EMF-dependent inhibition of cell proliferation. Exposure to Thomas-EMF delayed cell cycle progression and altered cyclin expression consistent with the decrease in cell proliferation. Non-malignant cells did not show any EMF-dependent changes in Ca(2+ influx or cell growth. These data confirm that exposure to a specific EMF pattern can affect cellular processes and that exposure to Thomas-EMF may provide a potential anti-cancer therapy.

  10. Inhibition of cancer cell growth by exposure to a specific time-varying electromagnetic field involves T-type calcium channels.

    Science.gov (United States)

    Buckner, Carly A; Buckner, Alison L; Koren, Stan A; Persinger, Michael A; Lafrenie, Robert M

    2015-01-01

    Electromagnetic field (EMF) exposures affect many biological systems. The reproducibility of these effects is related to the intensity, duration, frequency, and pattern of the EMF. We have shown that exposure to a specific time-varying EMF can inhibit the growth of malignant cells. Thomas-EMF is a low-intensity, frequency-modulated (25-6 Hz) EMF pattern. Daily, 1 h, exposures to Thomas-EMF inhibited the growth of malignant cell lines including B16-BL6, MDA-MB-231, MCF-7, and HeLa cells but did not affect the growth of non-malignant cells. Thomas-EMF also inhibited B16-BL6 cell proliferation in vivo. B16-BL6 cells implanted in syngeneic C57b mice and exposed daily to Thomas-EMF produced smaller tumours than in sham-treated controls. In vitro studies showed that exposure of malignant cells to Thomas-EMF for > 15 min promoted Ca(2+) influx which could be blocked by inhibitors of voltage-gated T-type Ca(2+) channels. Blocking Ca(2+) uptake also blocked Thomas-EMF-dependent inhibition of cell proliferation. Exposure to Thomas-EMF delayed cell cycle progression and altered cyclin expression consistent with the decrease in cell proliferation. Non-malignant cells did not show any EMF-dependent changes in Ca(2+) influx or cell growth. These data confirm that exposure to a specific EMF pattern can affect cellular processes and that exposure to Thomas-EMF may provide a potential anti-cancer therapy.

  11. Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension.

    Science.gov (United States)

    Hong, Kwangseok; Li, Min; Nourian, Zahra; Meininger, Gerald A; Hill, Michael A

    2017-12-01

    Studies suggest that arteriolar pressure-induced vasoconstriction can be initiated by GPCRs (G protein-coupled receptors), including the AT 1 R (angiotensin II type 1 receptor). This raises the question, are such mechanisms regulated by negative feedback? The present studies examined whether RGS (regulators of G protein signaling) proteins in vascular smooth muscle cells are colocalized with the AT 1 R when activated by mechanical stress or angiotensin II and whether this modulates AT 1 R-mediated vasoconstriction. To determine whether activation of the AT 1 R recruits RGS5, an in situ proximity ligation assay was performed in primary cultures of cremaster muscle arteriolar vascular smooth muscle cells treated with angiotensin II or hypotonic solution in the absence or presence of candesartan (an AT 1 R blocker). Proximity ligation assay results revealed a concentration-dependent increase in trafficking/translocation of RGS5 toward the activated AT 1 R, which was attenuated by candesartan. In intact arterioles, knockdown of RGS5 enhanced constriction to angiotensin II and augmented myogenic responses to increased intraluminal pressure. Myogenic constriction was attenuated to a higher degree by candesartan in RGS5 siRNA-transfected arterioles, consistent with RGS5 contributing to downregulation of AT 1 R-mediated signaling. Further, translocation of RGS5 was impaired in vascular smooth muscle cells of spontaneously hypertensive rats. This is consistent with dysregulated (RGS5-mediated) AT 1 R signaling that could contribute to excessive vasoconstriction in hypertension. In intact vessels, candesartan reduced myogenic vasoconstriction to a greater extent in spontaneously hypertensive rats compared with controls. Collectively, these findings suggest that AT 1 R activation results in translocation of RGS5 toward the plasma membrane, limiting AT 1 R-mediated vasoconstriction through its role in G q/11 protein-dependent signaling. © 2017 American Heart Association, Inc.

  12. Mineral facilities of Europe

    Science.gov (United States)

    Almanzar, Francisco; Baker, Michael S.; Elias, Nurudeen; Guzman, Eric

    2010-01-01

    This map displays over 1,700 records of mineral facilities within the countries of Europe and western Eurasia. Each record represents one commodity and one facility type at a single geographic location. Facility types include mines, oil and gas fields, and plants, such as refineries, smelters, and mills. Common commodities of interest include aluminum, cement, coal, copper, gold, iron and steel, lead, nickel, petroleum, salt, silver, and zinc. Records include attributes, such as commodity, country, location, company name, facility type and capacity (if applicable), and latitude and longitude geographical coordinates (in both degrees-minutes-seconds and decimal degrees). The data shown on this map and in table 1 were compiled from multiple sources, including (1) the most recently available data from the U.S. Geological Survey (USGS) Minerals Yearbook (Europe and Central Eurasia volume), (2) mineral statistics and information from the USGS Minerals Information Web site (http://minerals.usgs.gov/minerals/pubs/country/europe.html), and (3) data collected by the USGS minerals information country specialists from sources, such as statistical publications of individual countries, annual reports and press releases of operating companies, and trade journals. Data reflect the most recently published table of industry structure for each country at the time of this publication. Additional information is available from the country specialists listed in table 2.

  13. Education to promote verbal communication by caregivers in geriatric care facilities.

    Science.gov (United States)

    Fukaya, Yasuko; Koyama, Sachiyo; Kimura, Yusuke; Kitamura, Takanori

    2009-12-01

    Our previous study divided the verbal communication between caregivers and elderly residents at geriatric care facilities into Type I communication (to elicit activities of daily living) and Type II communication (conversation that occurs in normal social life) and found that Type II communication promotes utterances by elderly residents. This study conducted an education intervention to promote Type II talking by caregivers and evaluated the results. At three geriatric care facilities, 243 caregivers who might care for 36 elderly residents experienced training involving lectures and group discussion to understand the importance of Type II talking and how to apply it to their daily work. A statistical comparison was applied to the changes in Type II talking duration from before the intervention, 1 week after the intervention, and 3 months after the intervention to evaluate the effect of the educational intervention. At two facilities, the Type II talking duration increased significantly from before the educational intervention to 1 week after the intervention and remained higher after 3 months. However, the educational intervention's effect was not clear at one facility. There was no significant difference in the elderly persons' total utterance duration, but it increased from before the intervention to 1 week after the intervention. After the educational intervention, the amount of Type II talking by the caregivers increased significantly 1 week after the intervention for two facilities, but although the amount of Type II talking was higher at 3 months than before the intervention, it was not as high as 1 week after the intervention.

  14. Involved mechanisms in the radioprotector effect of the insulinic-1 type growth factor (IGF-1) in the mucous of the small intestine

    International Nuclear Information System (INIS)

    Mohamad, N.; Medina, V.; Sambuco, L.; Gutierrez, A.; Nunez, M.; Martin, G.; Cricco, G.; Rivera, E.; Bergoc, R.; Croci, M.; Crescenti, E.

    2006-01-01

    The use of radiant therapies in malignant tissues presents the inconvenience of affecting also to the healthy tissues, mainly when these present a high rate of proliferation like in the case of the mucous of the small intestine. The growth factor of insulinic-1 type (IGF-1) it has been pointed out as a possible protector of normal tissues under irradiation conditions. The objective of this work was to evaluate the effect of the IGF-1 like radioprotector of the mucous of the small intestine in mice irradiated with 10 Gy to whole body, determining the histological characteristics of the tissue, the presence of apoptotic cells, the expression of antigen of cellular proliferation (PCNA) and of anti-oxidant enzymes. Four groups of mice were used: control, treated with IGF-1, irradiated and irradiated and treated with IGF-1. The two treated groups were injected subcutaneously with two dose by day of 2.5 μg of IGF-I /0.1ml during four days (days 1 at 4). The two irradiated groups 10 Gy received to whole body the day 2. The day 5 all the animals were sacrificed and cuts of the mucous of the small intestine were obtained. The histological cuts were evaluated by tint with hematoxyline-eosin; the presence of apoptotic cells its were determined by the Tunnel method (Apoptag kit); the expression of PCNA, superoxide dependent dismutase of copper and zinc (CuZnSOD), superoxide dependent dismutase of manganese (MnSOD), catalase (CAT) and glutathion peroxidase (GPX), by immunohistochemistry. The results demonstrated that the treatment with IGF-1 preserves the partially histology of the mucous of the intestine, the expression of PCNA and the presence of apoptotic cells in the crypts in front of the irradiation. The CuZnSOD it was expressed mainly in the hairiness and, in smaller measure, in the crypts increase in the group IR+IGF-1. The IGF-1 produced the expression of MnSOD in the crypts and in the intestinal hairiness. The expression of CAT in the hairiness increase significantly

  15. Protein domains involved in both in vivo and in vitro interactions between human T-cell leukemia virus type I tax and CREB.

    Science.gov (United States)

    Yin, M J; Paulssen, E J; Seeler, J S; Gaynor, R B

    1995-06-01

    Gene expression from the human T-cell leukemia virus type I (HTLV-I) long terminal repeat (LTR) is mediated by three cis-acting regulatory elements known as 21-bp repeats and the transactivator protein Tax. The 21-bp repeats can be subdivided into three motifs known as A, B, and C, each of which is important for maximal gene expression in response to Tax. The B motif contains nucleotide sequences known as a cyclic AMP response element (CRE) or tax-response element which binds members of the ATF/CREB family of transcription factors. Though mutations of this element in the HTLV-I LTR eliminate tax activation, Tax will not activate most other promoters containing these CRE sites. In this study, we investigated the mechanism by which Tax activates gene expression in conjunction with members of the ATF/CREB family. We found that Tax enhanced the binding of one member of the ATF/CREB family, CREB 1, to each of the three HTLV-I LTR 21-bp repeats but not another member designated CRE-BP1 or CREB2. Tax enhanced the binding of CREB1 to nonpalindromic CRE binding sites such as those found in the HTLV-I LTR, but Tax did not enhance the binding of CREB1 to palindromic CRE binding sites such as found in the somatostatin promoter. This finding may help explain the failure of Tax to activate promoters containing consensus CRE sites. These studies were extended by use of the mammalian two-hybrid system. Tax was demonstrated to interact directly with CREB1 but not with other bZIP proteins, including CREB2 and Jun. Site-directed mutagenesis of both Tax and CREB1 demonstrated that the amino terminus of Tax and both the basic and the leucine zipper regions of CREB1 were required for direct interactions between these proteins both in vivo and in vitro. This interaction occurred in vivo and thus did not require the presence of the HTLV-I 21-bp repeats, as previously suggested. These results define the domains required for interaction between Tax and CREB that are likely critical for the

  16. Issues related to the licensing of final disposal facilities for radioactive waste

    International Nuclear Information System (INIS)

    Medici, M.A.; Alvarez, D.E.; Lee Gonzales, H.; Piumetti, E.H.; Palacios, E.

    2010-01-01

    The licensing process of a final disposal facility for radioactive waste involves the design, construction, pre-operation, operation, closure and post closure stages. While design and pre-operational stages are, to a reasonable extent, similar to other kind of nuclear or radioactive facilities, construction, operation, closure and post-closure of a radioactive waste disposal facility have unique meanings. As consequence of that, the licensing process should incorporate these particularities. Considering the long timeframes involved at each stage of a waste disposal facility, it is convenient that the development of the project being implemented in and step by step process, be flexible enough as to adapt to new requirements that would arise as a consequence of technology improvements or due to variations in the socio-economical and political conditions. In Argentina, the regulatory Standard AR 0.1.1 establishes the general guideline for the 'Licensing of Class I facilities (relevant facilities)'. Nevertheless, for radioactive waste final disposal facilities a new specific guidance should be developed in addition to the Basic Standard mentioned. This paper describes the particularities of final disposal facilities indicating that a specific licensing system for this type of facilities should be foreseen. (authors) [es

  17. Structural concept of angle type of hot isolation valve and its test program at an out-of-pile test facility

    Energy Technology Data Exchange (ETDEWEB)

    Hada, Kazuhiko; Fujisaki, Katsuo; Shibata, Taijyu; Inagaki, Yoshiyuki; Hino, Ryutaro [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment; Koiso, Hiroshi

    1997-02-01

    The Japanese safety regulation generally requires to set an isolation valve at the penetration of the reactor containment vessel on the secondary helium piping system which connects a steam reforming hydrogen production system, located outside the reactor building, to an intermediate heat exchanger (IHX) in the HTTR reactor system. The hot secondary helium which is heated up to the high temperature of 905degC and at the high pressure of 4.1MPa is passing through the isolation valve. So far, such a hot isolation valve has not been industrialized. The present report presents a proposal of a structural design concept of an angle valve as a promising candidate of the hot isolation valve, and a proposal on a test program for demonstrating the technological feasibility of the concept at an out-of-pile test facility before installing at the HTTR. A closing time and a leak rate at a valve seat are the key design parameters for developing the design concept. To set a reasonable value to each parameter, safety requirements on the isolation valve were discussed at first. The target closing time and the acceptable design limit of leak rate at the valve seat for meeting the requirements were specified 30 seconds and 10 STP cm{sup 3}/s, respectively. A nickel-base superalloy Hastelloy XR is feasible as such a valve seat material as to withstand the internal/external pressure of 4.1MPa at the high temperature of 905degC, the severest loading conditions of the valve seat at the accident of secondary helium pipe rupture. Correlation of leak rate at the ambient temperature to that at an operating temperature (900degC) is one of key test subjects of test program at an out-of-pile test facility. Leak rate at the operating temperature is the real parameter to be checked but only the leak rate at the ambient temperature is measured at regulatory examination in service. A test method to develop such correlation was proposed. (author)

  18. Proposal of a neutron transmutation doping facility for n-type spherical silicon solar cell at high-temperature engineering test reactor.

    Science.gov (United States)

    Ho, Hai Quan; Honda, Yuki; Motoyama, Mizuki; Hamamoto, Shimpei; Ishii, Toshiaki; Ishitsuka, Etsuo

    2018-05-01

    The p-type spherical silicon solar cell is a candidate for future solar energy with low fabrication cost, however, its conversion efficiency is only about 10%. The conversion efficiency of a silicon solar cell can be increased by using n-type silicon semiconductor as a substrate. This study proposed a new method of neutron transmutation doping silicon (NTD-Si) for producing the n-type spherical solar cell, in which the Si-particles are irradiated directly instead of the cylinder Si-ingot as in the conventional NTD-Si. By using a 'screw', an identical resistivity could be achieved for the Si-particles without a complicated procedure as in the NTD with Si-ingot. Also, the reactivity and neutron flux swing could be kept to a minimum because of the continuous irradiation of the Si-particles. A high temperature engineering test reactor (HTTR), which is located in Japan, was used as a reference reactor in this study. Neutronic calculations showed that the HTTR has a capability to produce about 40t/EFPY of 10Ωcm resistivity Si-particles for fabrication of the n-type spherical solar cell. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. Facility decontamination technology workshop

    International Nuclear Information System (INIS)

    1980-10-01

    Purpose of the meeting was to provide a record of experience at nuclear facilities, other than TMI-2, of events and incidents which have required decontamination and dose reduction activities, and to furnish GPU and others involved in the TMI-2 cleanup with the results of that decontamination and dose reduction technology. Separate abstracts were prepared for 24 of the 25 papers; the remaining paper had been previously abstracted

  20. Facility decontamination technology workshop

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-10-01

    Purpose of the meeting was to provide a record of experience at nuclear facilities, other than TMI-2, of events and incidents which have required decontamination and dose reduction activities, and to furnish GPU and others involved in the TMI-2 cleanup with the results of that decontamination and dose reduction technology. Separate abstracts were prepared for 24 of the 25 papers; the remaining paper had been previously abstracted. (DLC)

  1. New Trends in Facility Asset Management.

    Science.gov (United States)

    Adams, Matt

    2000-01-01

    Explains new, positive trends in facility asset management that encompasses greater acceptance and involvement of facility managers in the financial planning process, greater awareness of the need for maintenance, and facility administrators taking a greater role with business officers. The new climate for alternative renewal financing proposals…

  2. Sporadic manipulation in money markets with central bank standing facilities

    OpenAIRE

    Ewerhart, Christian; Cassola, Nuno; Ejerskov, Steen; Valla, Natacha

    2004-01-01

    In certain market environments, a large investor may benefit from building up a futures position first and trading subsequently in the spot market (Kumar and Seppi, 1992). The present paper identifies a variation of this type of manipulation that might occur in money markets with an interest rate corridor. We show that manipulation involving the use of central bank facilities would be observable only sporadically. The probability of manipulation decreases when the central bank uses an active ...

  3. Involving women.

    Science.gov (United States)

    Agbo, J

    1994-01-01

    I am a primary health care (PHC) coordinator working with the May Day Rural project, a local NGO involved in integrated approaches and programs with rural communities in the Ga District of the Greater-Accra region in Ghana. When we talk about the community development approach we must first and foremost recognize that we are talking about women, because in the developing world frequent childbirths mean that her burden of mortality is higher than a man's; her workload is extremely heavy--whether in gardening, farming, other household duties, caring for the sick, or the rearing of children; she has a key role in PHC and community development, because men are always looking for greener pastures elsewhere, leaving the women behind. Women's concerns are critical in most health care projects and women and children are their main beneficiaries. Why not include women in the management team, project design, implementation and evaluation processes? That is what the May Day Rural project is practicing, encouraging women's participation and creating a relationship of trust. full text

  4. Frequency of and Prognostic Significance of Cardiac Involvement at Presentation in Hereditary Transthyretin-Derived Amyloidosis and the Value of N-Terminal Pro-B-Type Natriuretic Peptide.

    Science.gov (United States)

    Klaassen, Sebastiaan H C; Tromp, Jasper; Nienhuis, Hans L A; van der Meer, Peter; van den Berg, Maarten P; Blokzijl, Hans; van Veldhuisen, Dirk J; Hazenberg, Bouke P C

    2018-01-01

    The aim of this study is to assess the prevalence of cardiac involvement in hereditary transthyretin-derived (ATTRm) amyloidosis at the time of diagnosis and to determine the diagnostic and clinical value of N-terminal pro-B-type natriuretic peptide (NT-proBNP). The University Medical Center Groningen is the national center of expertise for amyloidosis. All consecutive patients between 1994 and 2016 with ATTRm amyloidosis were followed prospectively. Baseline was set at the time of the first positive biopsy. All patients underwent a standard cardiac and neurologic work-up. Cardiac involvement was defined by otherwise unexplained left and/or right ventricular wall hypertrophy on cardiac ultrasound and/or advanced conduction disturbances. Seventy-seven patients had ATTRm amyloidosis and were included in the study. The TTR V30M mutation was present in 30 patients (39%). In both the V30M and the non-V30M groups, the neurologic presentation dominated (77% vs 51%), whereas cardiac presentation was infrequent (7% vs 15%). Clinical work-up showed that cardiac involvement was present at baseline in 51% of all patients irrespective of genotype and was associated with increased overall mortality (hazard ratio 5.95, 95% confidence interval 2.12 to 16.7), independent from clinical confounders. At a cutoff level of 125 ng/L, NT-proBNP had a sensitivity of 92% for establishing cardiac involvement. In conclusion, irrespective of the frequent noncardiac presentation of ATTRm amyloidosis, cardiac involvement is already present at diagnosis in half of the patients and is associated with increased mortality. NT-proBNP is a useful marker to determine cardiac involvement in this disease. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Gamma-Ray Irradiation Effects on the Characteristics of New Material P Type 6H-SiC Ni-Schottky Diodes (Application For Nuclear Fuel Facilities)

    International Nuclear Information System (INIS)

    U-Sudjadi; T-Ohshima, N. Iwamoto; S-Hishiki; N-Iwamoto, K. Kawano

    2007-01-01

    Effects of gamma-ray irradiation on electrical characteristics of new material p type 6H-SiC Ni-Schottky diodes were investigated. Ni Schottky diodes fabricated on p type 6H-SiC epi-layer were irradiated with gamma-rays at RT. The electrical characteristics of the diodes were evaluated before and after irradiation. The value of the on-resistance does not change up to 1 MGy, and the value increases with increasing absorbed dose above 1 MGy. For n factor, no significant increase is observed below 500 kGy, however, the value increases above 500 kGy. Schottky Barrier Height (SBH) decreases with increasing absorbed dose. Leakage current tends to increase due to irradiation. (author)

  6. Advanced reactor experimental facilities

    International Nuclear Information System (INIS)

    Amri, A.; Papin, J.; Uhle, J.; Vitanza, C.

    2010-01-01

    For many years, the NEA has been examining advanced reactor issues and disseminating information of use to regulators, designers and researchers on safety issues and research needed. Following the recommendation of participants at an NEA workshop, a Task Group on Advanced Reactor Experimental Facilities (TAREF) was initiated with the aim of providing an overview of facilities suitable for carrying out the safety research considered necessary for gas-cooled reactors (GCRs) and sodium fast reactors (SFRs), with other reactor systems possibly being considered in a subsequent phase. The TAREF was thus created in 2008 with the following participating countries: Canada, the Czech Republic, Finland, France, Germany, Hungary, Italy, Japan, Korea and the United States. In a second stage, India provided valuable information on its experimental facilities related to SFR safety research. The study method adopted entailed first identifying high-priority safety issues that require research and then categorizing the available facilities in terms of their ability to address the safety issues. For each of the technical areas, the task members agreed on a set of safety issues requiring research and established a ranking with regard to safety relevance (high, medium, low) and the status of knowledge based on the following scale relative to full knowledge: high (100%-75%), medium (75 - 25%) and low (25-0%). Only the issues identified as being of high safety relevance and for which the state of knowledge is low or medium were included in the discussion, as these issues would likely warrant further study. For each of the safety issues, the TAREF members identified appropriate facilities, providing relevant information such as operating conditions (in- or out-of reactor), operating range, description of the test section, type of testing, instrumentation, current status and availability, and uniqueness. Based on the information collected, the task members assessed prospects and priorities

  7. Support facilities

    International Nuclear Information System (INIS)

    Williamson, F.S.; Blomquist, J.A.; Fox, C.A.

    1977-01-01

    Computer support is centered on the Remote Access Data Station (RADS), which is equipped with a 1000 lpm printer, 1000 cpm reader, and a 300 cps paper tape reader with 500-foot spools. The RADS is located in a data preparation room with four 029 key punches (two of which interpret), a storage vault for archival magnetic tapes, card files, and a 30 cps interactive terminal principally used for job inquiry and routing. An adjacent room provides work space for users, with a documentation library and a consultant's office, plus file storage for programs and their documentations. The facility has approximately 2,600 square feet of working laboratory space, and includes two fully equipped photographic darkrooms, sectioning and autoradiographic facilities, six microscope cubicles, and five transmission electron microscopes and one Cambridge scanning electron microscope equipped with an x-ray energy dispersive analytical system. Ancillary specimen preparative equipment includes vacuum evaporators, freeze-drying and freeze-etching equipment, ultramicrotomes, and assorted photographic and light microscopic equipment. The extensive physical plant of the animal facilities includes provisions for holding all species of laboratory animals under controlled conditions of temperature, humidity, and lighting. More than forty rooms are available for studies of the smaller species. These have a potential capacity of more than 75,000 mice, or smaller numbers of larger species and those requiring special housing arrangements. There are also six dog kennels to accommodate approximately 750 dogs housed in runs that consist of heated indoor compartments and outdoor exercise areas

  8. Waste isolation facility description: bedded salt

    Energy Technology Data Exchange (ETDEWEB)

    1976-09-01

    The waste isolation facility is designed to receive and store three basic types of solidified wastes: high-level wastes, intermediate level high-gamma transuranic waste, and low-gamma transuranic wastes. The facility under consideration in this report is designed for bedded salt at a depth of approximately 1800 ft. The present design for the facility includes an area which would be used initially as a pilot facility to test the viability of the concept, and a larger facility which would constitute the final storage area. The total storage area in the pilot facility is planned to be 77 acres and in the fuel facility 1601 acres. Other areas for shaft operations and access would raise the overall size of the total facility to slightly less than 2,000 acres. The following subjects are discussed in detail: surface facilities, shaft design and characteristics, design and construction of the underground waste isolation facility, ventilation systems, and design requirements and criteria. (LK)

  9. Waste isolation facility description: bedded salt

    International Nuclear Information System (INIS)

    1976-09-01

    The waste isolation facility is designed to receive and store three basic types of solidified wastes: high-level wastes, intermediate level high-gamma transuranic waste, and low-gamma transuranic wastes. The facility under consideration in this report is designed for bedded salt at a depth of approximately 1800 ft. The present design for the facility includes an area which would be used initially as a pilot facility to test the viability of the concept, and a larger facility which would constitute the final storage area. The total storage area in the pilot facility is planned to be 77 acres and in the fuel facility 1601 acres. Other areas for shaft operations and access would raise the overall size of the total facility to slightly less than 2,000 acres. The following subjects are discussed in detail: surface facilities, shaft design and characteristics, design and construction of the underground waste isolation facility, ventilation systems, and design requirements and criteria

  10. Highly pathogenic avian influenza virus H5N1 controls type I IFN induction in chicken macrophage HD-11 cells: a polygenic trait that involves NS1 and the polymerase complex

    Science.gov (United States)

    2012-01-01

    Background Influenza A viruses are well characterized to antagonize type I IFN induction in infected mammalian cells. However, limited information is available for avian cells. It was hypothesised that avian influenza viruses (AIV) with distinct virulence may interact differently with the avian innate immune system. Therefore, the type I IFN responses induced by highly virulent and low virulent H5N1 AIV and reassortants thereof were analysed in chicken cells. Results The highly pathogenic (HP) AIV A/chicken/Yamaguchi/7/04 (H5N1) (Yama) did not induce type I IFN in infected chicken HD-11 macrophage-like cells. This contrasted with an NS1 mutant Yama virus (Yama-NS1A144V) and with the attenuated H5N1 AIV A/duck/Hokkaido/Vac-1/04 (Vac) carrying the haemagglutinin (HA) of the Yama virus (Vac-Yama/HA), that both induced type I IFN in these cells. The substitution of the NS segment from Yama with that from Vac in the Yama backbone resulted in induction of type I IFN secretion in HD-11 cells. However, vice versa, the Yama NS segment did not prevent type I IFN induction by the Vac-Yama/HA virus. This was different with the PB1/PB2/PA segment reassortant Yama and Vac-Yama/HA viruses. Whereas the Yama virus with the Vac PB1/PB2/PA segments induced type I IFN in HD-11 cells, the Vac-Yama/HA virus with the Yama PB1/PB2/PA segments did not. As reported for mammalian cells, the expression of H5N1 PB2 inhibited the activation of the IFN-β promoter in chicken DF-1 fibroblast cells. Importantly, the Yama PB2 was more potent at inhibiting the IFN-β promoter than the Vac PB2. Conclusions The present study demonstrates that the NS1 protein and the polymerase complex of the HPAIV Yama act in concert to antagonize chicken type I IFN secretion in HD-11 cells. PB2 alone can also exert a partial inhibitory effect on type I IFN induction. In conclusion, the control of type I IFN induction by H5N1 HPAIV represents a complex phenotype that involves a particular viral gene constellation

  11. Facility effluent monitoring plan for 242-A Evaporator facility

    International Nuclear Information System (INIS)

    Crummel, G.M.; Gustavson, R.D.

    1993-03-01

    A facility effluent monitoring plan is required by the US Department of Energy in DOE Order 5400.1* for any operations that involve hazardous materials and radioactive substances that could affect employee or public safety or the environment. A facility effluent monitoring plan determination was performed during Calendar Year 1991 and the evaluation showed the need for a facility effluent monitoring plan. This document is prepared using the specific guidelines identified in A Guide for Preparing Hanford Site Facility effluent Monitoring Plans, WHC-EP-0438-1**. This facility effluent monitoring plan assesses effluent monitoring systems and evaluates whether they are adequate to ensure the public health and safety as specified in applicable federal, state, and local requirements

  12. Iterated Hardy-type inequalities involving suprema

    Czech Academy of Sciences Publication Activity Database

    Gogatishvili, Amiran; Mustafayev, R.Ch.

    2017-01-01

    Roč. 20, č. 4 (2017), s. 901-927 ISSN 1331-4343 R&D Projects: GA ČR GA13-14743S Institutional support: RVO:67985840 Keywords : quasilinear operators * iterated Hardy inequalities * weights Subject RIV: BA - General Mathematics OBOR OECD: Pure mathematics Impact factor: 0.603, year: 2016 http://files.ele-math.com/preprints/mia-20-57.pdf

  13. On-field investigation and process modelling of end-of-life vehicles treatment in the context of Italian craft-type authorized treatment facilities.

    Science.gov (United States)

    Berzi, Lorenzo; Delogu, Massimo; Giorgetti, Alessandro; Pierini, Marco

    2013-04-01

    The present article analyses the current situation of End-of-Life-of-Vehicles (ELVs) management in Europe, with particular attention on Italian condition. Similarly to other European countries, metal recycling is the main activity of the whole system, but such situation is evolving due to the 2000/53/EC Directive, which sets out targets for Reuse, Recycling and Recovery of ELVs. Due to the relevance of the ELVs problem, in 2008 Italian Ministry of Environment subscribed a framework agreement with competent stakeholders as carmakers, dismantlers, shredders. The main result is an industrial plan to promote (amongst other objectives) technological progress for residual waste (Automotive Shredder Residue-ASR) treatment. According with Italian Trial 2006 analysis about ELVs, Reuse and Recycling rate is currently estimated to be about 81%. At the present time, dismantling plants constitute the first collection points for ELVs; for this reason, during 2009 an investigation has been done over a number of ten Authorized Treatment Facilities (ATFs) operating in Italy. The first step of the analysis was aimed to find out major practices and methods through observations of ATFs activities and interviews to operators. Furthermore, the depollution and dismantling treatments of about 70 different ELVs have been observed and timed in detail over a period of three months. The results included the identification of most relevant critical issues in ELVs treatment, such as distortions between scrapping activities and Directive's regulation, and the assessment of the time and of the resources needed to perform each operation. In the second step of the survey, a process simulation model has been built on the basis of such data. The model was aimed to include the real variability and all the uncertainties that are typical of dismantling activities; it is intended as a tool for process layout planning and for its management. Some control parameters have been introduced; these are able to

  14. Use of base isolation techniques for the design of high-level waste storage facility enclosure at INEL

    International Nuclear Information System (INIS)

    Vallenas, J.M.; Wong, Chun K.; Beer, M.J.

    1993-08-01

    Current Department of Energy criteria for facilities subjected to natural hazards provide guidelines to place facilities or portions of facilities into usage categories. Usage categories are based on characteristics such as mission dependence, type of hazardous materials involved, and performance goals. Seismic requirements are significantly more stringent for facilities falling into higher ''hazard facility use categories''. A special problem arises in cases where a facility or portion of a facility is dependent on another facility of lower ''hazard facility use category'' for support or protection. Creative solutions can minimize the cost Unpact of ensuring that the lower category item does not compromise the performance of the higher category item. In this paper, a base isolation solution is provided for a ''low hazard facility use category'' weather enclosure designed so it will not collapse onto a ''high hazard facility use category'' high level waste storage facility at INEL. This solution is compared to other more conventional procedures. Details, practical limitations, licensing and regulatory considerations, and cost comparisons are provided

  15. Facility effluent monitoring plan for the tank farm facility

    Energy Technology Data Exchange (ETDEWEB)

    Crummel, G.M.

    1998-05-18

    A facility effluent monitoring plan is required by the US Department of Energy in DOE Order 5400.1 for any operations that involve hazardous materials and radioactive substances that could impact employee or public safety or the environment. This document is prepared using the specific guidelines identified in A Guide for Preparing Hanford Site Facility Effluent Monitoring Plans, WHC-EP-0438. This facility effluent monitoring plan assesses effluent monitoring systems and evaluates whether they are adequate to ensure the public health and safety as specified in applicable federal, state, and local requirements.

  16. Integrated management of organic wastes for remediation of massive tailings storage facilities under semiarid mediterranean climate type: efficacy of organic pork residues as study case

    Science.gov (United States)

    Ginocchio, Rosanna; Arellano, Eduardo; España, Helena; Gardeweg, Rosario; Bas, Fernando; Gandarillas, Mónica

    2016-04-01

    Remediation of large surface areas of massive mine wastes, such as tailings storage facilities (TSFs) is challenging, particularly when no topsoils have been stored for the mine closure stage. Worldwide, it has been demonstrated that the use of organic wastes as substrate amendments for remediation of hard rock mine wastes is a useful alternative to topsoils material. In the case of semi-arid climate conditions of north-central Chile, the copper mining industry has generated massive TSF (between 400 ha and 3,000 ha) which needs now to be properly closed according to recently established mine closure regulations. However, in most of the cases, there have been no topsoils savage that facilitate the initial stage of the site remediation. Industrial organic wastes (i.e. biosolids) are found in the area, but their availability is normally below the demand needed for remediation of TSFs and salt content is normally elevated, thus posing salinization risks to the substrate and negative plant growth. We focused on a large organic waste producing industry, the pork industry, whose growth has been restricted due to the limited possibilities for using pig slurries as amendments for croplands in north-central Chile and the strong odor generated, resulting in conflicts with local communities. Incorporation of pig slurries as amendments to post-operative TSFs has been scarcely evaluated at international level (i.e. Spain) and no evaluation at all exists for the solid organic fraction generated from pig slurry treatment plants (PSTP). In the present study, we evaluated the efficacy of both pig slurries (PS) and the solid fraction of PSTP (SF-PSTP) as tailings amendment for creating good plant productivity on TSFs located under semi-arid Mediterranean climate conditions in north-central Chile. A short-term greenhouse study was developed. Copper mine tailings were mixed either with PS (0, 40, 80, and 120 m3 ha-1) or SF-PSTP (0, 25, 50 and 75 t ha-1), distributed in 3 L pots, and

  17. Decommissioning of Nuclear Facilities: Training and Human Resource Considerations

    International Nuclear Information System (INIS)

    2008-01-01

    One of the cornerstones of the success of nuclear facility decommissioning is the adequate competence of personnel involved in decommissioning activities. The purpose of this publication is to provide methodological guidance for, and specific examples of good practices in training as an integral part of human resource management for the personnel performing decommissioning activities. The use of the systematic methodology and techniques described in this publication may be tailored and applied to the development of training for all types of nuclear facilities undergoing decommissioning. Examples of good practices in other aspects of human resources, such as knowledge preservation, management of the workforce and improvement of human performance, are also covered. The information contained in this publication, and the examples provided in the appendices and enclosed CD-ROM, are representative of the experience of decommissioning of a wide variety of nuclear facilities.

  18. Structural safety assessment of a tokamak-type fusion facility for a through crack to cause cooling water leakage and plasma disruption

    International Nuclear Information System (INIS)

    Nakahira, Masataka

    2004-01-01

    A tokamak-type fusion machine has inherent safety associated with plasma shutdown. A small water leak can cause a plasma disruption although there is another possibility to terminate plasma without disruption. This plasma disruption will induce electromagnetic (EM) forces acting in the vacuum vessel (VV). From a radiological safety viewpoint, the VV is designed to form a physical barrier that encloses tritium and activated dust. If the VV can sustain an unstable fracture by EM forces from a through crack to cause the small leak, the structural safety will be assured and the inherent safety will be demonstrated. Therefore, a systematic approach to assure the structural safety is developed. A new analytical model to evaluate the through crack and leak rate of cooling water is proposed, with verification by experimental leak measurements. Based on the analysis, the critical crack length to terminate plasma is evaluated as about 2mm. On the other hand, the critical crack length for unstable fracture is obtained as about 400 mm. It is concluded that EM forces induced by the small leak to terminate plasma will not cause unstable fracture of the VV; thus the inherent safety is demonstrated. (author)

  19. Facile one-step template-free synthesis of uniform hollow microstructures of cryptomelane-type manganese oxide K-OMS-2.

    Science.gov (United States)

    Galindo, Hugo M; Carvajal, Yadira; Njagi, Eric; Ristau, Roger A; Suib, Steven L

    2010-08-17

    Hollow microstructures of cryptomelane-type manganese oxide were produced in a template-free one-step process based on the fine-tuning of the oxidation rate of manganese species during the synthesis. The tuning of the reaction rate brought about by a mixture of the oxidants oxone and potassium nitrate becomes apparent from the gradual physical changes taking place in the reaction medium at early times of the synthesis. The successful synthesis of the hollow uniform structures could be performed in the ranges 120-160 degrees C and 8.2-10.7 for temperature and mass ratio oxone/potassium nitrate, respectively. Independent of the conditions of the synthesis, all of the complex microstructures showed the same pattern for the array of very long nanofibers in which some of these elongated around the surface confining the cavity and the other fibers grew normal to the surface created by the previous arrangement. A mechanism based on the heterogeneous nucleation of the cryptomelane phase on the surface of an amorphous precursor and the growth of the nanoscale fibers by processes such as dissolution-crystallization and lateral attachment of primary nanocrystalline fibers is proposed to explain the formation of the hollow structures.

  20. Decommissioning of nuclear facilities: 'it can and has been done'

    International Nuclear Information System (INIS)

    2009-01-01

    Considerable international experience gained over the last 20 years demonstrates that nuclear facilities can be safely dismantled and decommissioned once a decision is made to cease operations and permanently shut them down. The term decommissioning is used to describe all the management and technical actions associated with ceasing operation of a nuclear installation and its subsequent dismantling to facilitate its removal from regulatory control (de-licensing). These actions involve decontamination of structures and components, dismantling of components and demolition of buildings, remediation of any contaminated ground and removal of the resulting waste. Worldwide, of the more than 560 commercial nuclear power plants that are or have been in operation, about 120 plants have been permanently shut down and are at some stage of decommissioning. About 10% of all shutdown plants have been fully decommissioned, including eight reactors of more than 100 MWe. A larger number of various types of fuel cycle and research facilities have also been shut down and decommissioned, including: facilities for the extraction and enrichment of uranium, facilities for fuel fabrication and reprocessing, laboratories, isotope production facilities and particle accelerators. This brochure looks at decommissioning across a spectrum of nuclear facilities and shows worldwide examples of successful projects. Further information can be found in NEA publications and on a number of web-sites

  1. Factors related to the decision-making for moving the older adults into long-term care facilities in Taiwan.

    Science.gov (United States)

    Hsieh, Yen-Ping; Huang, Ying-Chia; Lan, Shou-Jen; Ho, Ching-Sung

    2017-09-01

    To investigate the relationships between demographic characteristics of the elderly, type of long-term care (LTC) facilities, and the reasons for moving into LTC facilities. Research participants included people aged over 65 years, living in LTC facilities. A total of 1280 questionnaires were distributed to 111 LTC facilities in Taiwan; 480 questionnaires were retrieved, and 232 were included in the valid sample. The study used a non-linear canonical correlation analysis, which assesses the relationships among similar sets of categorical variables. The results showed that the older adults in quadrant I were characterized by being involved in the decision-making regarding the choice of LTC facilities and received economic support from their children. The older adults in quadrant II mainly lived in LTC facilities to receive medical care, whereas those in quadrant III typically included individuals with low income, who did not choose to live in LTC facilities. Furthermore, those in quadrant IV had positive cognitions associated with LTC facilities. We believe that the results of the present study will facilitate policy-making in the field of LTC, provide reference to the practitioners and the older adults, and identify the types of decisions older adults make when moving into LTC facilities, thus assisting older adults to improve their strategies regarding staying in LTC facilities. Geriatr Gerontol Int 2017; 17: 1319-1327. © 2016 Japan Geriatrics Society.

  2. Sol-Generating Chemical Vapor into Liquid (SG-CViL) deposition – a facile method for encapsulation of diverse cell types in silica matrices

    Energy Technology Data Exchange (ETDEWEB)

    Johnston, Robert [New Mexico Inst. of Mining and Technology, Socorro, NM (United States). Materials Engineering Dept.; Rogelj, Snezna [New Mexico Inst. of Mining and Technology, Socorro, NM (United States). Biology Dept.; Harper, Jason C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Bioenergy and Biodefense Technologies Dept.; Tartis, Michaelann [New Mexico Inst. of Mining and Technology, Socorro, NM (United States). Materials and Chemical Engineering Dept.

    2014-12-12

    In nature, cells perform a variety of complex functions such as sensing, catalysis, and energy conversion which hold great potential for biotechnological device construction. However, cellular sensitivity to ex vivo environments necessitates development of bio–nano interfaces which allow integration of cells into devices and maintain their desired functionality. In order to develop such an interface, the use of a novel Sol-Generating Chemical Vapor into Liquid (SG-CViL) deposition process for whole cell encapsulation in silica was explored. In SG-CViL, the high vapor pressure of tetramethyl orthosilicate (TMOS) is utilized to deliver silica into an aqueous medium, creating a silica sol. Cells are then mixed with the resulting silica sol, facilitating encapsulation of cells in silica while minimizing cell contact with the cytotoxic products of silica generating reactions (i.e. methanol), and reduce exposure of cells to compressive stresses induced from silica condensation reactions. Using SG-CVIL, Saccharomyces cerevisiae (S. cerevisiae) engineered with an inducible beta galactosidase system were encapsulated in silica solids and remained both viable and responsive 29 days post encapsulation. By tuning SG-CViL parameters, thin layer silica deposition on mammalian HeLa and U87 human cancer cells was also achieved. Thus, the ability to encapsulate various cell types in either a multi cell (S. cerevisiae) or a thin layer (HeLa and U87 cells) fashion shows the promise of SG-CViL as an encapsulation strategy for generating cell–silica constructs with diverse functions for incorporation into devices for sensing, bioelectronics, biocatalysis, and biofuel applications.

  3. Comparison of tritium production facilities

    International Nuclear Information System (INIS)

    He Kaihui; Huang Jinhua

    2002-01-01

    Detailed investigation and research on the source of tritium, tritium production facilities and their comparison are presented based on the basic information about tritium. The characteristics of three types of proposed tritium production facilities, i.e., fissile type, accelerator production tritium (APT) and fusion type, are presented. APT shows many advantages except its rather high cost; fusion reactors appear to offer improved safety and environmental impacts, in particular, tritium production based on the fusion-based neutron source costs much lower and directly helps the development of fusion energy source

  4. Air Quality Facilities

    Data.gov (United States)

    Iowa State University GIS Support and Research FacilityFacilities with operating permits for Title V of the Federal Clean Air Act, as well as facilities required to submit an air emissions inventory, and other facilities...

  5. Health physics considerations at a neutron therapy facility cyclotron

    International Nuclear Information System (INIS)

    Kleck, J.H.; Krueger, D.J.; Mc Laughlin, J.E.; Smathers, J.B.

    1987-01-01

    The U.C.L.A. Neutron Therapy Facility (NTF) is one of four such facilities in the United States currently involved in NCI sponsored trials of neutron therapy and reflects the present interest in the use of high energy neutron beams for treating certain types of human cancers. The NTF houses a CP-45 negative ion cyclotron which accelerates a 46 MeV proton beam for production of neutrons from a beryllium target. In addition to patient treatment, the NTF is involved in the production of positron emitting radioisotopes for diagnostic use in Positron Emission Tomography (PET). The activation of therapy treatment collimators, positron and neutron target systems, and a high and rapidly varying external radiation environment in a clinical setting have contributed to the need for a comprehensive radiation control program in which patient care is balanced with the maintenance of occupational exposures to ALARA levels

  6. Systems management of facilities agreements

    International Nuclear Information System (INIS)

    Blundell, A.

    1998-01-01

    The various types of facilities agreements, the historical obstacles to implementation of agreement management systems and the new opportunities emerging as industry is beginning to make an effort to overcome these obstacles, are reviewed. Barriers to computerized agreement management systems (lack of consistency, lack of standards, scarcity of appropriate computer software) are discussed. Characteristic features of a model facilities agreement management system and the forces driving the changing attitudes towards such systems (e.g. mergers) are also described

  7. The Generic Data Capture Facility

    Science.gov (United States)

    Connell, Edward B.; Barnes, William P.; Stallings, William H.

    1987-01-01

    The Generic Data Capture Facility, which can provide data capture support for a variety of different types of spacecraft while enabling operations costs to be carefully controlled, is discussed. The data capture functions, data protection, isolation of users from data acquisition problems, data reconstruction, and quality and accounting are addressed. The TDM and packet data formats utilized by the system are described, and the development of generic facilities is considered.

  8. Factors associated with hypoglycemia episodes in hospitalized type ...

    African Journals Online (AJOL)

    Purpose: To determine the factors associated with severity of hypoglycemia in hospitalized type 2 diabetes mellitus patients in a tertiary health facility in Malaysia. Methods: This retrospective study involved 207 hospitalised T2DM patients with hypoglycaemia episodes from January 2008 to December 2012 and was ...

  9. Pumps for nuclear facilities

    International Nuclear Information System (INIS)

    1999-01-01

    The guide describes how the Finnish Radiation and Nuclear Safety Authority (STUK) controls pumps and their motors at nuclear power plants and other nuclear facilities. The scope of the control is determined by the Safety Class of the pump in question. The various phases of the control are: (1) review of construction plan, (2) control of manufacturing, and construction inspection, (3) commissioning inspection, and (4) control during operation. STUK controls Safety Class 1, 2 and 3 pumps at nuclear facilities as described in this guide. STUK inspects Class EYT (non-nuclear) pumps separately or in connection with the commissioning inspections of the systems. This guide gives the control procedure and related requirements primarily for centrifugal pumps. However, it is also applied to the control of piston pumps and other pump types not mentioned in this guide

  10. Universal Test Facility

    Science.gov (United States)

    Laughery, Mike

    A universal test facility (UTF) for Space Station Freedom is developed. In this context, universal means that the experimental rack design must be: automated, highly marketable, and able to perform diverse microgravity experiments according to NASA space station requirements. In order to fulfill these broad objectives, the facility's customers, and their respective requirements, are first defined. From these definitions, specific design goals and the scope of the first phase of this project are determined. An examination is first made into what types of research are most likely to make the UTF marketable. Based on our findings, the experiments for which the UTF would most likely be used included: protein crystal growth, hydroponics food growth, gas combustion, gallium arsenide crystal growth, microorganism development, and cell encapsulation. Therefore, the UTF is designed to fulfill all of the major requirements for the experiments listed above. The versatility of the design is achieved by taking advantage of the many overlapping requirements presented by these experiments.

  11. Separations canyon decontamination facilities

    International Nuclear Information System (INIS)

    Hershey, J.H.

    1975-01-01

    Highly radioactive process equipment is decontaminated at the Savannah River Plant in specially equipped areas of the separations canyon building so that direct mechanical repairs or alterations can be made. Using these facilities it is possible to decontaminate and repair equipment such as 10- x 11-ft storage tanks, 8- x 8-ft batch evaporator pots and columns, 40-in. Bird centrifuges, canyon pumps and agitators, and various canyon piping systems or ''jumpers.'' For example, centrifuge or evaporator pots can be decontaminated and rebuilt for about 60 percent of the 1974 replacement cost. The combined facilities can decontaminate and repair 6 to 10 pieces of major equipment per year. Decontamination time varies with type of equipment and radioactivity levels encountered

  12. Separations canyon decontamination facilities

    International Nuclear Information System (INIS)

    Hershey, J.H.

    1975-05-01

    Highly radioactive process equipment is decontaminated at the Savannah River Plant in specially equipped areas of the separations canyon buildings so that direct mechanical repairs or alterations can be made. Using these facilities it is possible to decontaminate and repair equipment such as 10- x 11-ft storage tanks, 8- x 8-ft batch evaporator pots and columns, 40-in. Bird centrifuges, canyon pumps and agitators, and various canyon piping systems or ''jumpers.'' For example, centrifuge or evaporator pots can be decontaminated and rebuilt for about 60 percent of the 1974 replacement cost. The combined facilities can decontaminate and repair 6 to 10 pieces of major equipment per year. Decontamination time varies with type of equipment and radioactivity levels encountered. (U.S.)

  13. Facility effluent monitoring plan for the plutonium uranium extraction facility

    Energy Technology Data Exchange (ETDEWEB)

    Wiegand, D.L.

    1994-09-01

    A facility effluent monitoring plan is required by the US Department of Energy in DOE Order 5400.1 for any operations that involve hazardous materials and radioactive substances that could impact employee or public safety or the environment. This document is prepared using the specific guidelines identified in A Guide for Preparing Hanford Site Facility Effluent Monitoring Plans, WHC-EP-0438-01. This facility effluent monitoring plan assesses effluent monitoring systems and evaluates whether they are adequate to ensure the public health and safety as specified in applicable federal, state, and local requirements. This facility effluent monitoring plan shall ensure long-range integrity of the effluent monitoring systems by requiring an update whenever a new process or operation introduces new hazardous materials or significant radioactive materials. This document must be reviewed annually even if there are no operational changes, and it must be updated at a minimum of every three years.

  14. Facility Effluent Monitoring Plan for the uranium trioxide facility

    International Nuclear Information System (INIS)

    Lohrasbi, J.; Johnson, D.L.; De Lorenzo, D.S.

    1993-12-01

    A facility effluent monitoring plan is required by the US Department of Energy in DOE Order 5400.1 for any operations that involve hazardous materials and radioactive substances that could impact employee or public safety or the environment. This document is prepared using the specific guidelines identified in A Guide for Preparing Hanford Site Facility Effluent Monitoring Plans, WHC-EP-0438-01. This facility effluent monitoring plan assesses effluent monitoring systems and evaluates whether they are adequate to ensure the public health and safety as specified in applicable federal, state, and local requirements. This facility effluent monitoring plan shall ensure long-range integrity of the effluent monitoring systems by requiring an update whenever a new process or operation introduces new hazardous materials or significant radioactive materials. This document must be reviewed annually even if there are no operational changes, and it must be updated at a minimum of every three years

  15. Facility effluent monitoring plan for the plutonium uranium extraction facility

    International Nuclear Information System (INIS)

    Wiegand, D.L.

    1994-09-01

    A facility effluent monitoring plan is required by the US Department of Energy in DOE Order 5400.1 for any operations that involve hazardous materials and radioactive substances that could impact employee or public safety or the environment. This document is prepared using the specific guidelines identified in A Guide for Preparing Hanford Site Facility Effluent Monitoring Plans, WHC-EP-0438-01. This facility effluent monitoring plan assesses effluent monitoring systems and evaluates whether they are adequate to ensure the public health and safety as specified in applicable federal, state, and local requirements. This facility effluent monitoring plan shall ensure long-range integrity of the effluent monitoring systems by requiring an update whenever a new process or operation introduces new hazardous materials or significant radioactive materials. This document must be reviewed annually even if there are no operational changes, and it must be updated at a minimum of every three years

  16. Facility effluent monitoring plan for the Plutonium Uranium Extraction Facility

    International Nuclear Information System (INIS)

    Greager, E.M.

    1997-01-01

    A facility effluent monitoring plan is required by the US Department of Energy in DOE Order 5400.1 for any operations that involve hazardous materials and radioactive substances that could impact employee or public safety or the environment. This document is prepared using the specific guidelines identified in A Guide for Preparing Hanford Site Facility Effluent Monitoring Plans, WHC-EP-0438-01. This facility effluent monitoring plan assesses effluent monitoring systems and evaluates whether these systems are adequate to ensure the public health and safety as specified in applicable federal, state, and local requirements. This facility effluent monitoring plan will ensure long-range integrity of the effluent monitoring systems by requiring an update whenever a new process or operation introduces new hazardous materials or significant radioactive materials. This document must be reviewed annually even if there are no operational changes, and it must be updated, at a minimum, every 3 years

  17. Human T-Cell Leukemia Virus Type I-Mediated Repression of PDZ-LIM Domain-Containing Protein 2 Involves DNA Methylation But Independent of the Viral Oncoprotein Tax

    Directory of Open Access Journals (Sweden)

    Pengrong Yan

    2009-10-01

    Full Text Available Human T-cell leukemia virus type I (HTLV-I is the etiological agent of adult T-cell leukemia (ATL. Our recent studies have shown that one important mechanism of HTLV-I-Mediated tumorigenesis is through PDZ-LIM domain-containing protein 2 (PDLIM2 repression, although the involved mechanism remains unknown. Here, we further report that HTLV-I-Mediated PDLIM2 repression was a pathophysiological event and the PDLIM2 repression involved DNA methylation. Whereas DNA methyltransferases 1 and 3b but not 3a were upregulated in HTLV-I-transformed T cells, the hypomethylating agent 5-aza-2′-deoxycytidine (5-aza-dC restored PDLIM2 expression and induced death of these malignant cells. Notably, the PDLIM2 repression was independent of the viral regulatory protein Tax because neither short-term induction nor long-term stable expression of Tax could downregulate PDLIM2 expression. These studies provide important insights into PDLIM2 regulation, HTLV-I leukemogenicity, long latency, and cancer health disparities. Given the efficient antitumor activity with no obvious toxicity of 5-aza-dC, these studies also suggest potential therapeutic strategies for ATL.

  18. The C2H2-type transcription factor, FlbC, is involved in the transcriptional regulation of Aspergillus oryzae glucoamylase and protease genes specifically expressed in solid-state culture.

    Science.gov (United States)

    Tanaka, Mizuki; Yoshimura, Midori; Ogawa, Masahiro; Koyama, Yasuji; Shintani, Takahiro; Gomi, Katsuya

    2016-07-01

    Aspergillus oryzae produces a large amount of secreted proteins in solid-state culture, and some proteins such as glucoamylase (GlaB) and acid protease (PepA) are specifically produced in solid-state culture, but rarely in submerged culture. From the disruption mutant library of A. oryzae transcriptional regulators, we successfully identified a disruption mutant showing an extremely low production level of GlaB but a normal level of α-amylase production. This strain was a disruption mutant of the C2H2-type transcription factor, FlbC, which is reported to be involved in the regulation of conidiospore development. Disruption mutants of other upstream regulators comprising a conidiation regulatory network had no apparent effect on GlaB production in solid-state culture. In addition to GlaB, the production of acid protease in solid-state culture was also markedly decreased by flbC disruption. Northern blot analyses revealed that transcripts of glaB and pepA were significantly decreased in the flbC disruption strain. These results suggested that FlbC is involved in the transcriptional regulation of genes specifically expressed under solid-state cultivation conditions, possibly independent of the conidiation regulatory network.

  19. Public interest group involvement

    International Nuclear Information System (INIS)

    Shelley, P.

    1986-01-01

    Including public interest groups in the siting process for nuclear waste disposal facilities is of great importance. Controversial sitings often result in litigation, but involving public interest groups early in the process will lessen the change of this. They act as surrogates for the general public and should be considered as members of the team. It is important to remember though, that all public interest groups are different. In choosing public panels such as public advisory committees, members should not be chosen on the basis of some quota. Opposition groups should not be excluded. Also, it is important to put the right person in charge of the committee. The goal of public involvement is to identify the conflicts. This must be done during the decision process, because conflicts must be known before they can be eliminated. Regarding litigation, it is important to ease through and around legal battles. If the siting process has integrity and a good faith effort has been shown, the court should uphold the effort. In addition, it is important to be negotiable and to eliminate shortcuts

  20. Roles and relationships between health professionals involved in insulin initiation for people with type 2 diabetes in the general practice setting: a qualitative study drawing on relational coordination theory.

    Science.gov (United States)

    Manski-Nankervis, Jo-Anne; Furler, John; Blackberry, Irene; Young, Doris; O'Neal, David; Patterson, Elizabeth

    2014-01-31

    The majority of care for people with type 2 diabetes occurs in general practice, however when insulin initiation is required it often does not occur in this setting or in a timely manner and this may have implications for the development of complications. Increased insulin initiation in general practice is an important goal given the increasing prevalence of type 2 diabetes and a relative shortage of specialists. Coordination between primary and secondary care, and between medical and nursing personnel, may be important in achieving this. Relational coordination theory identifies key concepts that underpin effective interprofessional work: communication which is problem solving, timely, accurate and frequent and relationships between professional roles which are characterized by shared goals, shared knowledge and mutual respect. This study explores roles and relationships between health professionals involved in insulin initiation in order to gain an understanding of factors which may impact on this task being carried out in the general practice setting. 21 general practitioners, practice nurses, diabetes nurse educators and physicians were purposively sampled to participate in a semi-structured interview. Transcripts of the interviews were analysed using framework analysis. There were four closely interlinked themes identified which impacted on how health professionals worked together to initiate people with type 2 diabetes on insulin: 1. Ambiguous roles; 2. Uncertain competency and capacity; 3. Varying relationships and communication; and 4. Developing trust and respect. This study has shown that insulin initiation is generally recognised as acceptable in general practice. The role of the DNE and practice nurse in this space and improved communication and relationships between health professionals across organisations and levels of care are factors which need to be addressed to support this clinical work. Relational coordination provides a useful framework for

  1. Automated methodology for estimating waste streams generated from decommissioning contaminated facilities

    International Nuclear Information System (INIS)

    Toth, J.J.; King, D.A.; Humphreys, K.K.; Haffner, D.R.

    1994-01-01

    As part of the DOE Programmatic Environmental Impact Statement (PEIS), a viable way to determine aggregate waste volumes, cost, and direct labor hours for decommissioning and decontaminating facilities is required. In this paper, a methodology is provided for determining waste streams, cost and direct labor hours from remediation of contaminated facilities. The method is developed utilizing U.S. facility remediation data and information from several decommissioning programs, including reactor decommissioning projects. The method provides for rapid, consistent analysis for many facility types. Three remediation scenarios are considered for facility D ampersand D: unrestricted land use, semi-restricted land use, and restricted land use. Unrestricted land use involves removing radioactive components, decontaminating the building surfaces, and demolishing the remaining structure. Semi-restricted land use involves removing transuranic contamination and immobilizing the contamination on-site. Restricted land use involves removing the transuranic contamination and leaving the building standing. In both semi-restricted and restricted land use scenarios, verification of containment with environmental monitoring is required. To use the methodology, facilities are placed in a building category depending upon the level of contamination, construction design, and function of the building. Unit volume and unit area waste generation factors are used to calculate waste volumes and estimate the amount of waste generated in each of the following classifications: low-level, transuranic, and hazardous waste. Unit factors for cost and labor hours are also applied to the result to estimate D ampersand D cost and labor hours

  2. Dry-type radioactive material storage facility

    International Nuclear Information System (INIS)

    Yamanaka, Yasuharu; Matsuda, Masami; Kanai, Hidetoshi; Ganda, Takao.

    1996-01-01

    A plurality of container tubes containing a plurality of canisters therein are disposed in a canister storage chamber. High level radioactive materials are filled in the canisters in the form of glass solidification materials. The canister storage chamber is divided into two cooling channels by a horizontal partition wall. Each of the container tubes is suspended from a ceiling slab and pass through the horizontal partition wall. Namely, each of the container tubes vertically traverses the cooling channel formed between the ceiling slab and the partition wall and extends to the cooling channel formed between the partition wall and a floor slab. Cooling gases heated in the cooling channel below the partition wall are suppressed from rising to the cooling channel above the partition wall. Therefore, the container tubes are efficiently cooled even in a cooling channel above the partition wall to unify temperature distribution in the axial direction of the container tubes. (I.N.)

  3. Lining facility for FBR type reactor

    International Nuclear Information System (INIS)

    Ishitori, Takashi.

    1992-01-01

    Liner blocks of a dual layer structure made of sodium resistant and heat resistant refractories are laid on the surfaces of the floor and the wall of a concrete building containing pipelines in which coolants are circulated. The gas permeability of materials on one side of the liner block in contact with the surface of the floor or the wall is made greater than that of materials on the other side. Cavities are formed in the central portion of the block for releasing water content evaporated from the surfaces of the floor and the wall to the outside. With such a constitution, since it is no more necessary to weld and join a great number of steel plates, such as steel liners, laying operation is facilitated and the amount of materials required is reduced. In addition, damages of the liner blocks due to pressure elevation can be presented. (T.M.)

  4. Facility of BWR type nuclear power plant

    International Nuclear Information System (INIS)

    Kubo, Mitsuji

    1998-01-01

    A condensate filtering device for cleaning condensate flown from a low pressure turbine and a condensate desalting device are connected by way of a condensate pipeline. Control rod drives (CRD) are disposed to the lower portion of BWR. A CRD pump and one end of a CRD feedwater pipeline are connected in series to the upstream of CRD. The other end of the CRD feedwater pipeline is connected to a CRD water taking pipeline branched from the condensate pipeline. Water is taken to the CRD from downstream of the condensate filtering device and upstream of a connecting portion between a low pressure heater drain pipeline and the condensate pipeline. Flow of impurities leached out of the condensate desalting device to the reactor can be suppressed, and rising of temperature of CRD water by the low pressure heater drain water is prevented. In addition, flowing of dissolved oxygen to the CRD system can be suppressed. (I.N.)

  5. Facile and green synthesis of (La0.95Eu0.052O2S red phosphors with sulfate-ion pillared layered hydroxides as a new type of precursor: controlled hydrothermal processing, phase evolution and photoluminescence

    Directory of Open Access Journals (Sweden)

    Xuejiao Wang

    2014-01-01

    Full Text Available This study presents a facile and green route for the synthesis of (La0.95Eu0.052O2S red phosphors of controllable morphologies, with the sulfate-type layered hydroxides of Ln2(OH4SO4centerdot2H2O (Ln = La and Eu as a new type of precursor. The technique takes advantage of the fact that the precursor has had the exact Ln:S molar ratio of the targeted phosphor, thus saving the hazardous sulfurization reagents indispensable to traditional synthesis. Controlled hydrothermal processing at 120 °C yielded phase-pure Ln2(OH4SO4centerdot2H2O crystallites in the form of either nanoplates or microprisms, which can both be converted into Ln2O2S phosphor via a Ln2O2SO4 intermediate upon annealing in flowing H2 at a minimum temperature of ~ 700 °C. The nanoplates collapse into relatively rounded Ln2O2S particles while the microprisms retain well their initial morphologies at 1 200 °C, thus yielding two types of red phosphors. Photoluminescence excitation (PLE studies found two distinct charge transfer (CT excitation bands of O2− → Eu3+ at ~ 270 nm and S2− → Eu3+ at ~ 340 nm for the Ln2O2S phosphors, with the latter being stronger and both significantly stronger than the intrinsic intra-f transitions of Eu3+. The two types of phosphors share high similarities in the positions of PLE/PL (photoluminescence bands and both show the strongest red emission at 627 nm (5D0 → 7F2 transition of Eu3+ under S2− → Eu3+ CT excitation at 340 nm. The PLE/PL intensities show clear dependence on particle morphology and calcination temperature, which were investigated in detail. Fluorescence decay analysis reveals that the 627 nm red emission has a lifetime of ~ 0.5 ms for both types of the phosphors.

  6. Active use of urban park facilities

    DEFF Research Database (Denmark)

    Lindberg, Michael; Schipperijn, Jasper

    2015-01-01

    groups of the facilities. Facilities that provide the opportunity for games and playing activities are more used for PA than facilities directed at individual training of strength and fitness. The opportunity for socializing and playing while being physically active seems important for many users...... was mentioned as a key factor when designing facilities. Our results provide important knowledge to architects, planners and policy makers when aiming at designing activity-promoting facilities in UGS. Future studies need to further investigate the use of facilities among specific target groups, particularly......Abstract Urban green spaces (UGS), and more specific a higher number of facilities in UGS, have been positively associated with physical activity (PA). However, more detailed studies of which facilities generate high levels of PA, for which type of users, are relevant as existing knowledge...

  7. Radioactive contamination incidents involving protective clothing

    International Nuclear Information System (INIS)

    Reichelt, R.; Clay, M.; Eichorst, J.

    1996-10-01

    The study focuses on incidents at Department of Energy (DOE) facilities involving the migration of radioactive contaminants through protective clothing. The authors analyzed 68 occurrence reports for the following factors: (1) type of work; (2) working conditions; (3) type of anti-contamination (anti-C) material; (4) area of body or clothing contaminated; and (5) nature of spread of contamination. A majority of reports identified strenuous work activities such as maintenance, construction, or decontamination and decommissioning (D ampersand D) projects. The reports also indicated adverse working conditions that included hot and humid or cramped work environments. The type of anti-C clothing most often identified was cotton or water-resistant, disposable clothing. Most of the reports also indicated contaminants migrating through perspiration-soaked areas, typically in the knees and forearms. On the basis of their survey, the authors recommend the use of improved engineering controls and resilient, breathable, waterproof protective clothing for work in hot, humid, or damp areas where the possibility of prolonged contact with contamination cannot be easily avoided or controlled

  8. Radioactive contamination incidents involving protective clothing

    Energy Technology Data Exchange (ETDEWEB)

    Reichelt, R.; Clay, M.; Eichorst, J.

    1996-10-01

    The study focuses on incidents at Department of Energy (DOE) facilities involving the migration of radioactive contaminants through protective clothing. The authors analyzed 68 occurrence reports for the following factors: (1) type of work; (2) working conditions; (3) type of anti-contamination (anti-C) material; (4) area of body or clothing contaminated; and (5) nature of spread of contamination. A majority of reports identified strenuous work activities such as maintenance, construction, or decontamination and decommissioning (D&D) projects. The reports also indicated adverse working conditions that included hot and humid or cramped work environments. The type of anti-C clothing most often identified was cotton or water-resistant, disposable clothing. Most of the reports also indicated contaminants migrating through perspiration-soaked areas, typically in the knees and forearms. On the basis of their survey, the authors recommend the use of improved engineering controls and resilient, breathable, waterproof protective clothing for work in hot, humid, or damp areas where the possibility of prolonged contact with contamination cannot be easily avoided or controlled.

  9. Radioactive contamination incidents involving protective clothing

    International Nuclear Information System (INIS)

    Reichelt, R.A.; Clay, M.E.; Eichorst, A.J.

    1998-01-01

    The study focuses on incidents at Department of Energy facilities involving the migration of radioactive contaminants through protective clothing. The authors analyzed 68 occurrence reports for the following factors: (1) type of work, (2) working conditions, (3) type of anti-contamination material; (4) area of body or clothing contaminated; and (5) nature of spread of contamination. A majority of reports identified strenuous work activities such as maintenance, construction, or decontamination and decommissioning projects. The reports also indicated adverse working conditions that included hot and humid or cramped work environments. The type of anti-contamination clothing most often identified was cotton or water-resistant disposable clothing. Most of the reports also indicated contaminants migrating through perspiration-soaked areas, typically in the knees and forearms. On the basis of their survey, the authors recommend the use of improved engineering controls and resilient, breathable, waterproof protective clothing for work in hot, humid, or damp areas where the possibility of prolonged contact with contamination cannot be easily avoided or controlled. 1 ref., 6 figs., 1 tab

  10. Shiva target irradiation facility

    International Nuclear Information System (INIS)

    Manes, K.R.; Ahlstrom, H.G.; Coleman, L.W.; Storm, E.K.; Glaze, J.A.; Hurley, C.A.; Rienecker, F.; O'Neal, W.C.

    1977-01-01

    The first laser/plasma studies performed with the Shiva laser system will be two sided irradiations extending the data obtained by other LLL lasers to higher powers. The twenty approximately 1 TW laser pulses will reach the target simultaneously from above and below in nested pentagonal clusters. The upper and lower clusters of ten beams each are radially polarized so that they strike the target in p-polarization and maximize absorption. This geometry introduces laser system isolation problems which will be briefly discussed. The layout and types of target diagnostics will be described and a brief status report on the facility given

  11. Progress towards a new Canadian irradiation-research facility

    International Nuclear Information System (INIS)

    Lee, A.G.; Lidstone, R.F.

    1993-01-01

    As reported at the second meeting of the International Group on Research Reactors, Atomic Energy of Canada Limited (AECL) is evaluating its options for future irradiation facilities. During the past year significant progress has been made towards achieving consensus on the irradiation requirements for AECL's major research programs and interpreting those requirements in terms of desirable characteristics for experimental facilities in a research reactor. The next stage of the study involves identifying near-term and long-term options for irradiation-research facilities to meet the requirements. The near-term options include assessing the availability of the NRU reactor and the capabilities of existing research reactors. The long-term options include developing a new irradiation-research facility by adapting the technology base for the MAPLE-X10 reactor design. Because materials testing in support of CANDU power reactors dominates AECL's irradiation requirements, the new reactor concept is called the MAPLE Materials Testing Reactor (MAPLE-MTR). Parametric physics and engineering studies are in progress on alternative MAPLE-MTR configurations to assess the capabilities for the following types of test facilities: - fast-neutron sites, that accommodate materials-irradiation assemblies, - small-diameter vertical fuel test loops that accommodate multielement assemblies, - large-diameter vertical fuel test loops, each able to hold one or more CANDU fuel bundles, - horizontal test loops, each able to hold full-size CANDU fuel bundles or small-diameter multi-element assemblies, and - horizontal beam tubes

  12. Requirements and design concept for a facility mapping system

    International Nuclear Information System (INIS)

    Barry, R.E.; Burks, B.L.; Little, C.Q.

    1995-01-01

    The Department of Energy (DOE) has for some time been considering the Decontamination and Dismantlement (D ampersand D) of facilities which are no longer in use, but which are highly contaminated with radioactive wastes. One of the holdups in performing the D ampersand D task is the accumulation of accurate facility characterizations that can enable a safe and orderly cleanup process. According to the Technical Strategic Plan for the Decontamination and Decommissioning Integrated Demonstration, open-quotes the cost of characterization using current baseline technologies for approximately 100 acres of gaseous diffusion plant at Oak Ridge alone is, for the most part incalculableclose quotes. Automated, robotic techniques will be necessary for initial characterization and continued surveillance of these types of sites. Robotic systems are being designed and constructed to accomplish these tasks. This paper describes requirements and design concepts for a system to accurately map a facility contaminated with hazardous wastes. Some of the technologies involved in the Facility Mapping System are: remote characterization with teleoperated, sensor-based systems, fusion of data sets from multiple characterization systems, and object recognition from 3D data models. This Facility Mapping System is being assembled by Oak Ridge National Laboratory for the DOE Office of Technology Development Robotics Technology Development Program

  13. Efeito do bebedouro e da densidade no desempenho de frangos alojados em alta temperatura Effect of type of water facility and density on performance of broiler reared in hot-climate

    Directory of Open Access Journals (Sweden)

    José H.V. Silva

    2005-12-01

    Full Text Available Com o objetivo de avaliar o efeito do bebedouro pendular (BP e do bebedouro alternativo (BALT, e de diferentes densidades (10 e 14 aves m-2 sobre o desempenho de 240 frangos de corte de 12 a 18, 19 a 38 e de 39 a 46 dias de idade, realizou-se este experimento em condições de temperatura média de 27,6 ºC e umidade relativa de 70,4%, no qual foi utilizado um delineamento inteiramente casualizado em esquema fatorial 2 x 2 (dois bebedouros x duas densidades, resultando em quatro tratamentos constituídos de cinco repetições de 10 aves. O BALT foi desenvolvido com base no conceito de amplo espaço de calha circular e alta profundidade de lâmina de água (5 cm para permitir a imersão do bico e das faces da ave. Na alimentação das aves, foram utilizadas rações comerciais, cujo consumo (CR caiu, enquanto a conversão alimentar (CA melhorou, quando o BALT foi empregado de 12 a 18 dias. Não houve efeito do bebedouro sobre o CR, ganho de peso (GP e CA no período total. A D14 (14 aves m-2 afetou o GP e o CR de 19 a 38 e de 39 a 46 dias e também no período total, mas a CA não foi alterada. O BALT não afeta o desempenho de frangos de corte, podendo ser usado como opção de baixo custo ao BP. A análise econômica pelo índice de rentabilidade relativa mostrou que o BALT e a D14 oferecem 1 e 5,9% de retorno a mais que o BP e a D10, (10 aves m-2 respectivamente.The experiment was undertaken in conditions of average temperature of 27.6 ºC and relative humidity of 70.4%, with the objective to evaluate bell (BD and alternative (ALT water facility and stocking densities (SD of 10 and 14 broilers m-2 (SD10 and SD14, on performance of 240 broiler chickens of 12 to 18, 19 to 38 and 39 to 46 days of age, allotted in boxes in a completely randomized design in 2 x 2 factorial arrangement (two types of drinking facility and two stocking densities, resulting in four treatments, each one with five replications of ten birds. The ALT was developed based on

  14. ATLAS Facility Description Report

    International Nuclear Information System (INIS)

    Kang, Kyoung Ho; Moon, Sang Ki; Park, Hyun Sik; Cho, Seok; Choi, Ki Yong

    2009-04-01

    A thermal-hydraulic integral effect test facility, ATLAS (Advanced Thermal-hydraulic Test Loop for Accident Simulation), has been constructed at KAERI (Korea Atomic Energy Research Institute). The ATLAS has the same two-loop features as the APR1400 and is designed according to the well-known scaling method suggested by Ishii and Kataoka to simulate the various test scenarios as realistically as possible. It is a half-height and 1/288-volume scaled test facility with respect to the APR1400. The fluid system of the ATLAS consists of a primary system, a secondary system, a safety injection system, a break simulating system, a containment simulating system, and auxiliary systems. The primary system includes a reactor vessel, two hot legs, four cold legs, a pressurizer, four reactor coolant pumps, and two steam generators. The secondary system of the ATLAS is simplified to be of a circulating loop-type. Most of the safety injection features of the APR1400 and the OPR1000 are incorporated into the safety injection system of the ATLAS. In the ATLAS test facility, about 1300 instrumentations are installed to precisely investigate the thermal-hydraulic behavior in simulation of the various test scenarios. This report describes the scaling methodology, the geometric data of the individual component, and the specification and the location of the instrumentations in detail

  15. Structural integrity monitoring of critical components in nuclear facilities

    International Nuclear Information System (INIS)

    Roth, Maria; Constantinescu, Dan Mihai; Brad, Sebastian; Ducu, Catalin; Malinovschi, Viorel

    2007-01-01

    Full text: The paper presents the results obtained as part of the Project 'Integrated Network for Structural Integrity Monitoring of Critical Components in Nuclear Facilities', RIMIS, a research work underway within the framework of the Ministry of Education and Research Programme 'Research of Excellence'. The main objective of the Project is to constitute a network integrating the national R and D institutes with preoccupations in the structural integrity assessment of critical components in the nuclear facilities operating in Romania, in order to elaborate a specific procedure for this field. The degradation mechanisms of the structural materials used in the CANDU type reactors, operated by Unit 1 and Unit 2 at Cernavoda (pressure tubes, fuel elements sheaths, steam generator tubing) and in the nuclear facilities relating to reactors of this type as, for instance, the Hydrogen Isotopes Separation facility, will be investigated. The development of a flexible procedure will offer the opportunity to extend the applications to other structural materials used in the nuclear field and in the non-nuclear fields as well, in cooperation with other institutes involved in the developed network. The expected results of the project will allow the integration of the network developed at national level in the structures of similar networks operating within the EU, the enhancement of the scientific importance of Romanian R and D organizations as well as the increase of our country's contribution in solving the major issues of the nuclear field. (authors)

  16. Irradiation Facilities at CERN

    CERN Document Server

    Gkotse, Blerina; Carbonez, Pierre; Danzeca, Salvatore; Fabich, Adrian; Garcia, Alia, Ruben; Glaser, Maurice; Gorine, Georgi; Jaekel, Martin, Richard; Mateu,Suau, Isidre; Pezzullo, Giuseppe; Pozzi, Fabio; Ravotti, Federico; Silari, Marco; Tali, Maris

    2017-01-01

    CERN provides unique irradiation facilities for applications in many scientific fields. This paper summarizes the facilities currently operating for proton, gamma, mixed-field and electron irradiations, including their main usage, characteristics and information about their operation. The new CERN irradiation facilities database is also presented. This includes not only CERN facilities but also irradiation facilities available worldwide.

  17. Research Facilities | Wind | NREL

    Science.gov (United States)

    Research Facilities Research Facilities NREL's state-of-the-art wind research facilities at the Research Facilities Photo of five men in hard hards observing the end of a turbine blade while it's being tested. Structural Research Facilities A photo of two people silhouetted against a computer simulation of

  18. North Slope, Alaska ESI: FACILITY (Facility Points)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains data for oil field facilities for the North Slope of Alaska. Vector points in this data set represent oil field facility locations. This data...

  19. Anterior-inferior tibiofibular ligament anatomical repair and augmentation versus trans-syndesmosis screw fixation for the syndesmotic instability in external-rotation type ankle fracture with posterior malleolus involvement: A prospective and comparative study.

    Science.gov (United States)

    Zhan, Yu; Yan, Xiaoyu; Xia, Ronggang; Cheng, Tao; Luo, Congfeng

    2016-07-01

    Syndesmosis injury is common in external-rotation type ankle fractures (ERAF). Trans-syndesmosis screw fixation, the gold-standard treatment, is currently controversial for its complications and biomechanical disadvantages. The purpose of this study was to introduce a new method of anatomically repairing the anterior-inferior tibiofibular ligament (AITFL) and augmentation with anchor rope system to treat the syndesmotic instability in ERAF with posterior malleolus involvement and to compare its clinical outcomes with that of trans-syndesmosis screw fixation. 53 ERAFs with posterior malleolus involvement received surgery, and the syndesmosis was still unstable after fracture fixation. They were randomised into screw fixation group and AITFL anatomical repair with augmentation group. Reduction quality, syndesmosis diastasis recurrence, pain (VAS score), time back to work, Olerud-Molander ankle score and range of motion (ROM) of ankle were investigated. Olerud-Molander score in AITFL repair group and screw group was 90.4 and 85.8 at 12-month follow-up (P>0.05). Plantar flexion was 31.2° and 34.3° in repair and screw groups (P=0.04). Mal-reduction happened in 5 cases (19.2%) in screw group while 2 cases (7.4%) in repair group. Postoperative syndesmosis re-diastasis occurred in 3 cases in screw group while zero in repair group (P>0.05). Pain score was similar between the two groups (P>0.05). Overall complication rate and back to work time were 26.9% and 3.7% (P=0.04), 7.15 months and 5.26 months (P=0.02) in screw group and repair group, respectively. For syndesmotic instability in ERAF with posterior malleolus involvement, the method of AITFL anatomical repair and augmentation with anchor rope system had an equivalent functional outcome and reduction, earlier rehabilitation and less complication compared with screw fixation. It can be selected as an alternative. Copyright © 2016 Elsevier Ltd. All rights reserved.

  20. Involvement of PPAR-γ in the neuroprotective and anti-inflammatory effects of angiotensin type 1 receptor inhibition: effects of the receptor antagonist telmisartan and receptor deletion in a mouse MPTP model of Parkinson's disease

    Directory of Open Access Journals (Sweden)

    Garrido-Gil Pablo

    2012-02-01

    Full Text Available Abstract Background Several recent studies have shown that angiotensin type 1 receptor (AT1 antagonists such as candesartan inhibit the microglial inflammatory response and dopaminergic cell loss in animal models of Parkinson's disease. However, the mechanisms involved in the neuroprotective and anti-inflammatory effects of AT1 blockers in the brain have not been clarified. A number of studies have reported that AT1 blockers activate peroxisome proliferator-activated receptor gamma (PPAR γ. PPAR-γ activation inhibits inflammation, and may be responsible for neuroprotective effects, independently of AT1 blocking actions. Methods We have investigated whether oral treatment with telmisartan (the most potent PPAR-γ activator among AT1 blockers provides neuroprotection against dopaminergic cell death and neuroinflammation, and the possible role of PPAR-γ activation in any such neuroprotection. We used a mouse model of parkinsonism induced by the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP and co-administration of the PPAR-γ antagonist GW9662 to study the role of PPAR-γ activation. In addition, we used AT1a-null mice lesioned with MPTP to study whether deletion of AT1 in the absence of any pharmacological effect of AT1 blockers provides neuroprotection, and investigated whether PPAR-γ activation may also be involved in any such effect of AT1 deletion by co-administration of the PPAR-γ antagonist GW9662. Results We observed that telmisartan protects mouse dopaminergic neurons and inhibits the microglial response induced by administration of MPTP. The protective effects of telmisartan on dopaminergic cell death and microglial activation were inhibited by co-administration of GW9662. Dopaminergic cell death and microglial activation were significantly lower in AT1a-null mice treated with MPTP than in mice not subjected to AT1a deletion. Interestingly, the protective effects of AT1 deletion were also inhibited by co

  1. Facility effluent monitoring plan for 242-A evaporator facility

    International Nuclear Information System (INIS)

    Crummel, G.M.; Gustavson, R.D.

    1995-02-01

    A facility effluent monitoring plan is required by the U.S. Department of Energy in DOE Order 5400.1 for any operations that involve hazardous materials and radioactive substances that could affect employee or public safety or the environment. A facility effluent monitoring plan determination was performed during Calendar Year 1991 and the evaluation showed the need for a facility effluent monitoring plan. This document is prepared using the specific guidelines identified in A Guide for Preparing Hanford Site Facility Effluent Monitoring Plans, WHC-EP-0438-1. This facility effluent monitoring plan assesses effluent monitoring systems and evaluates whether they are adequate to ensure the public health and safety as specified in applicable federal, state, and local requirements. This facility effluent monitoring plan shall ensure long-range integrity of the effluent monitoring systems by requiring an update whenever a new process or operation introduces new hazardous materials or significant radioactive materials. This document must be reviewed annually even if there are no operational changes, and it must be updated, as a minimum, every three years

  2. Implementing RCRA during facility deactivation

    International Nuclear Information System (INIS)

    Lebaron, G.J.

    1997-01-01

    RCRA regulations require closure of permitted treatment, storage and disposal (TSD) facilities within 180 days after cessation of operations, and this may essentially necessitate decommissioning to complete closure. A more cost effective way to handle the facility would be to significantly reduce the risk to human health and the environment by taking it from its operational status to a passive, safe, inexpensive-to-maintain surveillance and maintenance condition (deactivation) prior to decommissioning. This paper presents an innovative approach to the cost effective deactivation of a large, complex chemical processing facility permitted under RCRA. The approach takes into account risks to the environment posed by this facility in comparison to risks posed by neighboring facilities at the site. The paper addresses the manner in which: 1) stakeholders and regulators were involved; 2) identifies a process by which the project proceeds and regulators and stakeholders were involved; 3) end points were developed so completion of deactivation was clearly identified at the beginning of the project, and 4) innovative practices were used to deactivate more quickly and cost effectively

  3. Facility safeguards at an LEU fuel fabrication facility in Japan

    International Nuclear Information System (INIS)

    Kuroi, H.; Osabe, T.

    1984-01-01

    A facility description of a Japanese LEU BWR-type fuel fabrication plant focusing on safeguards viewpoints is presented. Procedures and practices of MC and A plan, measurement program, inventory taking, and the report and record system are described. Procedures and practices of safeguards inspection are discussed and lessons learned from past experiences are reviewed

  4. Jupiter Laser Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Jupiter Laser Facility is an institutional user facility in the Physical and Life Sciences Directorate at LLNL. The facility is designed to provide a high degree...

  5. Basic Research Firing Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Basic Research Firing Facility is an indoor ballistic test facility that has recently transitioned from a customer-based facility to a dedicated basic research...

  6. A novel zinc finger protein 219-like (ZNF219L) is involved in the regulation of collagen type 2 alpha 1a (col2a1a) gene expression in zebrafish notochord.

    Science.gov (United States)

    Lien, Huang-Wei; Yang, Chung-Hsiang; Cheng, Chia-Hsiung; Hung, Chin-Chun; Liao, Wei-Hao; Hwang, Pung-Pung; Han, Yu-San; Huang, Chang-Jen

    2013-01-01

    The notochord is required for body plan patterning in vertebrates, and defects in notochord development during embryogenesis can lead to diseases affecting the adult. It is therefore important to elucidate the gene regulatory mechanism underlying notochord formation. In this study, we cloned the zebrafish zinc finger 219-like (ZNF219L) based on mammalian ZNF219, which contains nine C2H2-type zinc finger domains. Through whole-mount in situ hybridization, we found that znf219L mRNA is mainly expressed in the zebrafish midbrain-hindbrain boundary, hindbrain, and notochord during development. The znf219L morpholino knockdown caused partial abnormal notochord phenotype and reduced expression of endogenous col2a1a in the notochord specifically. In addition, ZNF219L could recognize binding sites with GGGGG motifs and trigger augmented activity of the col2a1a promoter in a luciferase assay. Furthermore, in vitro binding experiments revealed that ZNF219L recognizes the GGGGG motifs in the promoter region of the zebrafish col2a1a gene through its sixth and ninth zinc finger domains. Taken together, our results reveal that ZNF219L is involved in regulating the expression of col2a1a in zebrafish notochord specifically.

  7. Involvement in Physical Activity

    Directory of Open Access Journals (Sweden)

    James Gavin

    2013-04-01

    Full Text Available A total of 1,096 adolescents participated in 123 focus groups regarding the perceived outcomes of their involvement in sports and physical activity (PA. The groups, segmented by grade level, sex, and school types, were conducted in both public and private high schools in Montreal, Quebec. We sought to understand, through the participants’ own words, their perception of the outcome matrix of involvement in sports and PA. Focus group questions emphasized changes that adolescents associated with such engagement. In particular, participants were asked how sports and PA might influence behaviors, emotional states, personal characteristics, and other outcomes. Twelve themes were identified in the responses: Positive Health and Physical Changes (18.5%, Activity-Related Positive Emotions (15.6%, and Personal Learning (11.3% were most prevalent in the discussions. A cluster of deeper personal changes thematically described as Self-Identity, Autonomy, and Positive Character Development accounted for another 16.5% of the responses. Relatively few commentaries emphasized negative effects (7.1%. Converting the proportions of qualitative data into a quantitative index allowed us to analyze potential differences in emphasis according to sex, age, and school type. Though a few significant findings emerged, the larger pattern was of a uniform perceptual map across the variables for this adolescent sample. Implications drawn from this investigation highlight the need to clearly articulate concrete pathways to positive nonphysical changes (e.g., mood states, autonomy, positive character development from engagements in sports and PA.

  8. Aperture area measurement facility

    Data.gov (United States)

    Federal Laboratory Consortium — NIST has established an absolute aperture area measurement facility for circular and near-circular apertures use in radiometric instruments. The facility consists of...

  9. High Throughput Facility

    Data.gov (United States)

    Federal Laboratory Consortium — Argonne?s high throughput facility provides highly automated and parallel approaches to material and materials chemistry development. The facility allows scientists...

  10. Licensed Healthcare Facilities

    Data.gov (United States)

    California Natural Resource Agency — The Licensed Healthcare Facilities point layer represents the locations of all healthcare facilities licensed by the State of California, Department of Health...

  11. Facility Registry Service (FRS)

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Facility Registry Service (FRS) provides an integrated source of comprehensive (air, water, and waste) environmental information about facilities across EPA,...

  12. Scaling laws between population and facility densities.

    Science.gov (United States)

    Um, Jaegon; Son, Seung-Woo; Lee, Sung-Ik; Jeong, Hawoong; Kim, Beom Jun

    2009-08-25

    When a new facility like a grocery store, a school, or a fire station is planned, its location should ideally be determined by the necessities of people who live nearby. Empirically, it has been found that there exists a positive correlation between facility and population densities. In the present work, we investigate the ideal relation between the population and the facility densities within the framework of an economic mechanism governing microdynamics. In previous studies based on the global optimization of facility positions in minimizing the overall travel distance between people and facilities, it was shown that the density of facility D and that of population rho should follow a simple power law D approximately rho(2/3). In our empirical analysis, on the other hand, the power-law exponent alpha in D approximately rho(alpha) is not a fixed value but spreads in a broad range depending on facility types. To explain this discrepancy in alpha, we propose a model based on economic mechanisms that mimic the competitive balance between the profit of the facilities and the social opportunity cost for populations. Through our simple, microscopically driven model, we show that commercial facilities driven by the profit of the facilities have alpha = 1, whereas public facilities driven by the social opportunity cost have alpha = 2/3. We simulate this model to find the optimal positions of facilities on a real U.S. map and show that the results are consistent with the empirical data.

  13. Facility effluent monitoring plan for the tank farms facilities

    Energy Technology Data Exchange (ETDEWEB)

    Bachand, D.D.; Crummel, G.M.

    1995-05-01

    A facility effluent monitoring plan is required by the US Department of Energy for any operations that involve hazardous materials and radioactive substances that could impact employee or public safety or the environment. This document is prepared using specific guidelines. This facility effluent monitoring plan assesses effluent monitoring systems and evaluates whether they are adequate to ensure the public health and safety as specified in applicable federal, state, and local requirements. This facility effluent monitoring plan shall ensure long-range integrity of the effluent monitoring systems by requiring an update whenever a new process or operation introduces new hazardous materials or significant radioactive materials. This document must be reviewed annually even if there are no operational changes, and it must be updated as a minimum every three years.

  14. Recent Experiments Involving Few-Nucleon Systems

    Science.gov (United States)

    Tornow, W.

    2014-08-01

    Recent experimental results are presented for reactions involving A = 3 to A = 6 nuclear systems. The emphasis is on unique data obtained at new experimental facilities. It is shown that the inertial confinement fusion facilities OMEGA and NIF provide a largely unexpected opportunity for experimental few-body physics to both obtain data of unprecedented quality and extend previous measurements to energies not accessible in the past. Whenever possible, data are compared to state-of-the-art theoretical calculations.

  15. Recent Experiments Involving Few-Nucleon Systems

    International Nuclear Information System (INIS)

    Tornow, W.

    2014-01-01

    Recent experimental results are presented for reactions involving A = 3 to A = 6 nuclear systems. The emphasis is on unique data obtained at new experimental facilities. It is shown that the inertial confinement fusion facilities OMEGA and NIF provide a largely unexpected opportunity for experimental few-body physics to both obtain data of unprecedented quality and extend previous measurements to energies not accessible in the past. Whenever possible, data are compared to state-of-the-art theoretical calculations. (author)

  16. Siting controversial facilities

    International Nuclear Information System (INIS)

    Baird, R.D.; Blacker, P.B.

    1985-01-01

    There is often significant difficulty involved with siting controversial facilities. The social and political problems are frequently far more difficult to resolve than the technical and economic issues. The tendancy for most developing organizations is to address only technical issues in the search for a technically optimal site, to the exclusion of such weighting considerations as the social and political climate associated with potential sites--an approach which often imperils the success of the project. The site selection processes currently suggested is summarized and two contemporary examples of their application are cited. The difference between developers' real objectives and the objectives they have implicitly assumed by adopting the recommended approaches without augmentation are noted. The resulting morass of public opposition is attributed to the failure to consider the needs of individuals and groups who stand to be negatively impacted by the development. A comprehensive implementation strategy which addresses non-technical consideration in parallel with technical ones is presented and evaluated

  17. Water Supply and Sanitation Facility Accessibility in Off-Campus ...

    African Journals Online (AJOL)

    Water Supply and Sanitation Facility Accessibility in Off-Campus Houses ... on drinking water source, rate of illness, type and usage of sanitation facilities. ... wells, unprotected dug wells; while others during the wet season harvest rain water.

  18. Managing highly flexible facilities: an essential complementary asset at risk

    NARCIS (Netherlands)

    Tierney, Robert; Tierney, R.; Groen, Arend J.; Harms, Rainer; Luizink, M.; Hetherington, D.; Steward, H.; Walsh, Steven Thomas; Linton, Jonathan; Linton, J.D.

    2012-01-01

    Purpose: Twenty first century problems are increasingly being addressed by multi technology solutions developed by regional entrepreneurial and intreprepreneurial innovators. However, they require an expensive new type of fabrication facility. Multiple technology production facilities (MTPF) have

  19. CERN radiation protection (RP) calibration facilities

    Energy Technology Data Exchange (ETDEWEB)

    Pozzi, Fabio

    2016-04-14

    Radiation protection calibration facilities are essential to ensure the correct operation of radiation protection instrumentation. Calibrations are performed in specific radiation fields according to the type of instrument to be calibrated: neutrons, photons, X-rays, beta and alpha particles. Some of the instruments are also tested in mixed radiation fields as often encountered close to high-energy particle accelerators. Moreover, calibration facilities are of great importance to evaluate the performance of prototype detectors; testing and measuring the response of a prototype detector to well-known and -characterized radiation fields contributes to improving and optimizing its design and capabilities. The CERN Radiation Protection group is in charge of performing the regular calibrations of all CERN radiation protection devices; these include operational and passive dosimeters, neutron and photon survey-meters, and fixed radiation detectors to monitor the ambient dose equivalent, H*(10), inside CERN accelerators and at the CERN borders. A new state-of-the-art radiation protection calibration facility was designed, constructed and commissioned following the related ISO recommendations to replace the previous ageing (more than 30 years old) laboratory. In fact, the new laboratory aims also at the official accreditation according to the ISO standards in order to be able to release certified calibrations. Four radiation fields are provided: neutrons, photons and beta sources and an X-ray generator. Its construction did not only involve a pure civil engineering work; many radiation protection studies were performed to provide a facility that could answer the CERN calibration needs and fulfill all related safety requirements. Monte Carlo simulations have been confirmed to be a valuable tool for the optimization of the building design, the radiation protection aspects, e.g. shielding, and, as consequence, the overall cost. After the source and irradiator installation

  20. A Bioinformatics Facility for NASA

    Science.gov (United States)

    Schweighofer, Karl; Pohorille, Andrew

    2006-01-01

    Building on an existing prototype, we have fielded a facility with bioinformatics technologies that will help NASA meet its unique requirements for biological research. This facility consists of a cluster of computers capable of performing computationally intensive tasks, software tools, databases and knowledge management systems. Novel computational technologies for analyzing and integrating new biological data and already existing knowledge have been developed. With continued development and support, the facility will fulfill strategic NASA s bioinformatics needs in astrobiology and space exploration. . As a demonstration of these capabilities, we will present a detailed analysis of how spaceflight factors impact gene expression in the liver and kidney for mice flown aboard shuttle flight STS-108. We have found that many genes involved in signal transduction, cell cycle, and development respond to changes in microgravity, but that most metabolic pathways appear unchanged.