Simultaneous hyperpolarized 13C-pyruvate MRI and 18F-FDG-PET in cancer (hyperPET)

DEFF Research Database (Denmark)

Gutte, Henrik; Hansen, Adam E.; Henriksen, Sarah T.

2015-01-01

named this concept hyper PET. Intravenous injection of the hyperpolarized 13C-pyruvate results in an increase of 13C-lactate, 13C-alanine and 13CCO2 (13C-HCO3) resonance peaks relative to the tissue, disease and the metabolic state probed. Accordingly, with dynamic nuclear polarization (DNP) and use......In this paper we demonstrate, for the first time, the feasibility of a new imaging concept - combined hyperpolarized 13C-pyruvate magnetic resonance spectroscopic imaging (MRSI) and 18F-FDG-PET imaging. This procedure was performed in a clinical PET/MRI scanner with a canine cancer patient. We have...... of 13C-pyruvate it is now possible to directly study the Warburg Effect through the rate of conversion of 13C-pyruvate to 13C-lactate. In this study, we combined it with 18F-FDG-PET that studies uptake of glucose in the cells. A canine cancer patient with a histology verified local recurrence...

A database of linear codes over F_13 with minimum distance bounds and new quasi-twisted codes from a heuristic search algorithm

Directory of Open Access Journals (Sweden)

Eric Z. Chen

2015-01-01

Full Text Available Error control codes have been widely used in data communications and storage systems. One central problem in coding theory is to optimize the parameters of a linear code and construct codes with best possible parameters. There are tables of best-known linear codes over finite fields of sizes up to 9. Recently, there has been a growing interest in codes over $\\mathbb{F}_{13}$ and other fields of size greater than 9. The main purpose of this work is to present a database of best-known linear codes over the field $\\mathbb{F}_{13}$ together with upper bounds on the minimum distances. To find good linear codes to establish lower bounds on minimum distances, an iterative heuristic computer search algorithm is employed to construct quasi-twisted (QT codes over the field $\\mathbb{F}_{13}$ with high minimum distances. A large number of new linear codes have been found, improving previously best-known results. Tables of $[pm, m]$ QT codes over $\\mathbb{F}_{13}$ with best-known minimum distances as well as a table of lower and upper bounds on the minimum distances for linear codes of length up to 150 and dimension up to 6 are presented.

The RhoGAP Stard13 controls insulin secretion through F-actin remodeling

Directory of Open Access Journals (Sweden)

Heike Naumann

2018-02-01

Full Text Available Objective: Actin cytoskeleton remodeling is necessary for glucose-stimulated insulin secretion in pancreatic β-cells. A mechanistic understanding of actin dynamics in the islet is paramount to a better comprehension of β-cell dysfunction in diabetes. Here, we investigate the Rho GTPase regulator Stard13 and its role in F-actin cytoskeleton organization and islet function in adult mice. Methods: We used Lifeact-EGFP transgenic animals to visualize actin cytoskeleton organization and dynamics in vivo in the mouse islets. Furthermore, we applied this model to study actin cytoskeleton and insulin secretion in mutant mice deleted for Stard13 selectively in pancreatic cells. We isolated transgenic islets for 3D-imaging and perifusion studies to measure insulin secretion dynamics. In parallel, we performed histological and morphometric analyses of the pancreas and used in vivo approaches to study glucose metabolism in the mouse. Results: In this study, we provide the first genetic evidence that Stard13 regulates insulin secretion in response to glucose. Postnatally, Stard13 expression became restricted to the mouse pancreatic islets. We showed that Stard13 deletion results in a marked increase in actin polymerization in islet cells, which is accompanied by severe reduction of insulin secretion in perifusion experiments. Consistently, Stard13-deleted mice displayed impaired glucose tolerance and reduced glucose-stimulated insulin secretion. Conclusions: Taken together, our results suggest a previously unappreciated role for the RhoGAP protein Stard13 in the interplay between actin cytoskeletal remodeling and insulin secretion. Keywords: F-actin, Insulin secretion, Islet, Pancreas, Lifeact, Stard13

Simultaneous Hyperpolarized 13C-Pyruvate MRI and 18F-FDG PET (HyperPET) in 10 Dogs with Cancer

DEFF Research Database (Denmark)

Gutte, Henrik; Hansen, Adam E; Larsen, Majbrit M E

2015-01-01

with biopsy-verified spontaneous malignant tumors were included for imaging. All dogs underwent a protocol of simultaneous (18)F-FDG PET, anatomic MR, and hyperpolarized dynamic nuclear polarization with (13)C-pyruvate imaging. The data were acquired using a combined clinical PET/MR imaging scanner. We found...... that combined (18)F-FDG PET and (13)C-pyruvate MRS imaging was possible in a single session of approximately 2 h. A continuous workflow was obtained with the injection of (18)F-FDG when the dogs was placed in the PET/MR scanner. (13)C-MRS dynamic acquisition demonstrated in an axial slab increased (13)C......With the introduction of combined PET/MR spectroscopic (MRS) imaging, it is now possible to directly and indirectly image the Warburg effect with hyperpolarized (13)C-pyruvate and (18)F-FDG PET imaging, respectively, via a technique we have named hyperPET. The main purpose of this present study...

Characterization and expression of the human T cell receptor-T3 complex by monoclonal antibody F101.01

DEFF Research Database (Denmark)

Geisler, C; Plesner, T; Pallesen, G

1988-01-01

demonstrated co-expression of the antigen defined by F101.01 and the pan-T cell antigens defined by CD2, CD3, CD5, and CD7 antibodies. Cells stained with CD4 and CD8 antibodies were both included in the F101.01-positive population, whereas CD16-positive natural killer cells (NK), B cells (CD19 and CD20...

Existence of halo-structure for the first excited levels of both the 13C-13N and the 17O-17F nuclei

International Nuclear Information System (INIS)

Gridnev, K.A.; Novatskij, B.G.

2003-01-01

From calculated the Coulomb shifts difference for the carbon and oxygen isotopes analog levels the valent nucleons the orbit radius values R C and the density parameter r 0 are presented. It is shown that the density parameter values are slightly varying for the all analog nuclear pairs. The exception constitutes the first excited states of the 13 C- 13 N and the 17 O- 17 F nuclei, whose valent nucleons populate the 2s-shell (L=0). These states one can to consider as structures with brightly distinguished of the ( 13 C * , 17 O * ) neutron halo and the( 13 N * , 17 F * ) proton halo

High Yield F-18 Target for KOTRON-13 Cyclotron

International Nuclear Information System (INIS)

Lee, W. K.; Song, J. Y.; Park, J. Y.; Jung, K. I.; Chae, S. K.

2009-01-01

Currently the domestic radiation market for medical diagnosis witnesses a high increase of the use of PET/CT for the purpose of cancer diagnosis, and the cases of cancer diagnosis using PET/CT increase by geometric progression every year. In case of domestic practice, full body scan is taken by using FDG medical isotope medicines mainly using F-18, but the necessity of various medical radioactive isotopes according to each medical purpose is increasing. F-18 output yield is directly proportional to energy of protons and beam current, and has correlation with heat production rate in case of target and decides the function of target in accordance with the efficiency of a cooling device. At present, in case of most F-18 target, when one irradiates beam in O-18 water of about 0.2∼5mL, one has to apply heat of over 300W, a high thermal energy per unit area is irradiated in target, which is easily damaged, and it has limitation in beam current. Currently, in case of commercial target, about 2,000W beam current is the maximum value, and in case of double-grid target developed by Korea Institute of Radiological and Medical Sciences in 2004, it was designed to stand up to about 1,000W theoretically, but in reality it can irradiate lower beam current than this because of the shortage of cooling efficiency. In general, the irradiation strength to produce radioactive isotopes given in the heat emission by target substance currently is limited to 50μA against target substance irradiated in 1.6mL. However, current KOTRON-13 cyclotron can accelerate proton beam with a high scope of strength marking 100μA thru 120μA by a continuous development. Therefore, it doesn't fully function compared with that of proton beam of KOTRON-13 cyclotron. The solution about this is to get over the problem of cooling target substance of cavity in the production system of radioactive isotopes. Especially, one has to develop the method to cool target substance, and provide higher F-18 yield than

13.-20. VI võtab ehtekunstnike rühmitus F.F.F.F....

Index Scriptorium Estoniae

2004-01-01

Rühmitus F.F.F.F. (Ketli Tiitsar, Kristi Paap, Kaire Rannik, Berit Teeäär, Maria Valdma) võtab osa Bostonis toimuvast rahvusvahelisest ehtekunstinäitusest ja konverentsist "ContacT 2004", juhendab Massachusetts College of Art üliõpilastele ja kunstnikele korraldatud workshop'i "SWOP". Bakalar Gallerys esineb rühmitus näitusega "Igapäevaleib", osalejate individuaalset loomingut eksponeerib galerii Mobilia

Method for selective recovery of PET-usable quantities of [.sup.18 F] fluoride and [.sup.13 N] nitrate/nitrite from a single irradiation of low-enriched [.sup.18 O] water

Science.gov (United States)

Ferrieri, Richard A.; Schlyer, David J.; Shea, Colleen

1995-06-13

A process for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- for radiotracer synthesis is disclosed. The process includes producing [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- simultaneously by exposing a low-enriched (20%-30%) [.sup.18 O]H.sub.2 O target to proton irradiation, sequentially isolating the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [.sup.18 F]F.sup.- from the [.sup.18 O]H.sub.2 O target, and reducing the [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- to [.sup.13 N]NH.sub.3. The [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- products are then conveyed to a laboratory for radiotracer applications. The process employs an anion exchange resin for isolation of the isotopes from the [.sup.18 O]H.sub.2 O, and sequential elution of [.sup.13 N]NO.sub.2.sup.- /NO.sub.3.sup.- and [ .sup.18 F]F.sup.- fractions. Also the apparatus is disclosed for simultaneously producing PET-usable quantities of [.sup.13 N]NH.sub.3 and [.sup.18 F]F.sup.- from a single irradiation of a single low-enriched [.sup.18 O]H.sub.2 O target.

Allele frequency data for 16 STR loci in the Vietnamese population.

Science.gov (United States)

Shimada, I; Brinkmann, B; Tuyen, N Q; Hohoff, C

2002-08-01

The short tandem repeat systems ACTBP2, D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX and FGA were studied in a population sample from Vietnam (178 individuals, mainly from the Hanoi area). The 16 loci met Hardy-Weinberg expectations and possess a combined power of discrimination greater than 0.9999999999999999998 and a combined power of exclusion greater than 0.99999994 in this Vietnamese population.

Biological control of Fusarium solani f. sp. phaseoli the causal agent of root rot of bean using Bacillus subtilis CA32 and Trichoderma harzianum RU01

Directory of Open Access Journals (Sweden)

Saman Abeysinghe

2007-09-01

Full Text Available Root rot, caused by Fusarium solani f. sp. phaseoli, is one of the main root diseases impacting production of common bean in Sri Lanka. Rhizobacteria were screened in dual Petri plate assays to select antagonistic strains against F. solani f. sp. phaseoli. B. subtilis CA32 effectively antagonized the pathogen. T. harzianum RU01 also showed the antagonistic activity. The efficacy of the B. subtilis CA32 and the T. harzianum RU01 were tested in greenhouse pot experiments against F. solani f. sp. phaseoli. Seed bacterization with B. subtilis CA32 and T. harzianum RU01 significantly protected bean seedlings from F. solani f. sp. phaseoli compared to the untreated control plants. Plant protection was more pronounced in T. harzianum RU01 treated plants than bacterized plants. Enhanced root growth was observed only T. harzianum RU01 treated plants, suggesting that the biotic modifications of the mycorrhizosphere as a result of colonization with T. harzianum RU01.

A dual-reservoir remote loading water target system for 18F and 13N production with direct in-target liquid level sensing

International Nuclear Information System (INIS)

Ferrieri, R.A.; Alexoff, D.L.; Schlyer, D.J.; Wolf, A.P.

1991-01-01

This report describes our universal water target loading system that serves both [ 18 F] and [ 13 N] production targets, and a radionuclide delivery system that is specific for [ 18 F] fluoride. The system was designed and fabricated around the operation of a single pneumatic syringe dispenser that accesses one of two reservoirs filled with [ 18 O] enriched water for [ 18 F] fluoride production from the 18 O(p,n) 18 F reaction and natural abundance water for [ 13 N] nitrate/nitrite production from the 16 O(p,α) 13 N reaction and loads one of two targets depending on the radionuclide desired. The system offers several novel features for reliable radionuclide production. First, there exists an in-target probe for direct liquid level sensing using the conductivity response of water. In addition, transfer of [ 18 F] fluoride to the Hot Lab is completely decoupled from the irradiated water through the actions of a resin/recovery system which is located in the cyclotron vault, thus maintaining transfer line integrity. This feature also provides a mechanism for vault-containment of long-lived contaminants generated through target activation and leaching into the water

Method for selective recovery of PET-usable quantities of [{sup 18}F] fluoride and [{sup 13}N] nitrate/nitrite from a single irradiation of low-enriched [{sup 18}O] water

Science.gov (United States)

Ferrieri, R.A.; Schlyer, D.J.; Shea, C.

1995-06-13

A process for simultaneously producing PET-usable quantities of [{sup 13}N]NH{sub 3} and [{sup 18}F]F{sup {minus}} for radiotracer synthesis is disclosed. The process includes producing [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}}and [{sup 18}F]F{sup {minus}} simultaneously by exposing a low-enriched (20%-30%) [{sup 18}O]H{sub 2}O target to proton irradiation, sequentially isolating the [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}} and [{sup 18}F]F{sup {minus}} from the [{sup 18}O]H{sub 2}O target, and reducing the [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}} to [{sup 13}N]NH{sub 3}. The [{sup 13}N]NH{sub 3} and [{sup 18}F]F{sup {minus}} products are then conveyed to a laboratory for radiotracer applications. The process employs an anion exchange resin for isolation of the isotopes from the [{sup 18}O]H{sub 2}O, and sequential elution of [{sup 13}N]NO{sub 2}{sup {minus}}/NO{sub 3}{sup {minus}} and [{sup 18}F]F{sup {minus}} fractions. Also the apparatus is disclosed for simultaneously producing PET-usable quantities of [{sup 13}N]NH{sub 3} and [{sup 18}F]F{sup {minus}} from a single irradiation of a single low-enriched [{sup 18}O]H{sub 2}O target. 2 figs.

7 CFR 15f.13 - What is the function of the ALJ and who may communicate with him?

Science.gov (United States)

2010-01-01

... communicate with him? 15f.13 Section 15f.13 Agriculture Office of the Secretary of Agriculture ADJUDICATIONS... What is the function of the ALJ and who may communicate with him? (a) What are the powers of the ALJ... time between the assignment of a hearing to him or her and the issuance of a proposed determination...

The F4/AS01B HIV-1 Vaccine Candidate Is Safe and Immunogenic, But Does Not Show Viral Efficacy in Antiretroviral Therapy-Naive, HIV-1-Infected Adults: A Randomized Controlled Trial.

Science.gov (United States)

Dinges, Warren; Girard, Pierre-Marie; Podzamczer, Daniel; Brockmeyer, Norbert H; García, Felipe; Harrer, Thomas; Lelievre, Jean-Daniel; Frank, Ian; Colin De Verdière, Nathalie; Yeni, Guy-Patrick; Ortega Gonzalez, Enrique; Rubio, Rafael; Clotet Sala, Bonaventura; DeJesus, Edwin; Pérez-Elias, Maria Jesus; Launay, Odile; Pialoux, Gilles; Slim, Jihad; Weiss, Laurence; Bouchaud, Olivier; Felizarta, Franco; Meurer, Anja; Raffi, François; Esser, Stefan; Katlama, Christine; Koletar, Susan L; Mounzer, Karam; Swindells, Susan; Baxter, John D; Schneider, Stefan; Chas, Julie; Molina, Jean-Michel; Koutsoukos, Marguerite; Collard, Alix; Bourguignon, Patricia; Roman, François

2016-02-01

The impact of the investigational human immunodeficiency virus type 1 (HIV-1) F4/AS01B vaccine on HIV-1 viral load (VL) was evaluated in antiretroviral therapy (ART)-naive HIV-1 infected adults.This phase IIb, observer-blind study (NCT01218113), included ART-naive HIV-1 infected adults aged 18 to 55 years. Participants were randomized to receive 2 (F4/AS01B_2 group, N = 64) or 3 (F4/AS01B_3 group, N = 62) doses of F4/AS01B or placebo (control group, N = 64) at weeks 0, 4, and 28. Efficacy (HIV-1 VL, CD4 T-cell count, ART initiation, and HIV-related clinical events), safety, and immunogenicity (antibody and T-cell responses) were evaluated during 48 weeks.At week 48, based on a mixed model, no statistically significant difference in HIV-1 VL change from baseline was demonstrated between F4/AS01B_2 and control group (0.073 log10 copies/mL [97.5% confidence interval (CI): -0.088; 0.235]), or F4/AS01B_3 and control group (-0.096 log10 copies/mL [97.5% CI: -0.257; 0.065]). No differences between groups were observed in HIV-1 VL change, CD4 T-cell count, ART initiation, or HIV-related clinical events at intermediate timepoints. Among F4/AS01B recipients, the most frequent solicited symptoms were pain at injection site (252/300 doses), fatigue (137/300 doses), myalgia (105/300 doses), and headache (90/300 doses). Twelve serious adverse events were reported in 6 participants; 1 was considered vaccine-related (F4/AS01B_2 group: angioedema). F4/AS01B induced polyfunctional F4-specific CD4 T-cells, but had no significant impact on F4-specific CD8 T-cell and anti-F4 antibody levels.F4/AS01B had a clinically acceptable safety profile, induced F4-specific CD4 T-cell responses, but did not reduce HIV-1 VL, impact CD4 T-cells count, delay ART initiation, or prevent HIV-1 related clinical events.

DETECTION OF KOI-13.01 USING THE PHOTOMETRIC ORBIT

International Nuclear Information System (INIS)

Shporer, Avi; Jenkins, Jon M.; Seader, Shawn E.; Smith, Jeffrey C.; Thompson, Susan E.; Twicken, Joseph D.; Rowe, Jason F.; Sanderfer, Dwight T.; Still, Martin D.; Welsh, William F.

2011-01-01

We use the KOI-13 transiting star-planet system as a test case for the recently developed BEER algorithm, aimed at identifying non-transiting low-mass companions by detecting the photometric variability induced by the companion along its orbit. Such photometric variability is generated by three mechanisms: the beaming effect, tidal ellipsoidal distortion, and reflection/heating. We use data from three Kepler quarters, from the first year of the mission, while ignoring measurements within the transit and occultation, and show that the planet's ephemeris is clearly detected. We fit for the amplitude of each of the three effects and use the beaming effect amplitude to estimate the planet's minimum mass, which results in M p sin i = 9.2 ± 1.1 M J (assuming the host star parameters derived by Szabo et al.). Our results show that non-transiting star-planet systems similar to KOI-13.01 can be detected in Kepler data, including a measurement of the orbital ephemeris and the planet's minimum mass. Moreover, we derive a realistic estimate of the amplitudes uncertainties, and use it to show that data obtained during the entire lifetime of the Kepler mission of 3.5 years will allow detecting non-transiting close-in low-mass companions orbiting bright stars, down to the few Jupiter mass level. Data from the Kepler Extended Mission, if funded by NASA, will further improve the detection capabilities.

Substructure of a Tunisian Berber population as inferred from 15 autosomal short tandem repeat loci.

Science.gov (United States)

Khodjet-El-Khil, Houssein; Fadhlaoui-Zid, Karima; Gusmão, Leonor; Alves, Cíntia; Benammar-Elgaaied, Amel; Amorim, Antonio

2008-08-01

Currently, language and cultural practices are the only criteria to distinguish between Berber autochthonous Tunisian populations. To evaluate these populations' possible genetic structure and differentiation, we have analyzed 15 autosomal short tandem repeat loci (CSF1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, TH01, TPOX, VWA, D2S1338, and D19S433) in three southern Tunisian Berber groups: Sened, Matmata, and Chenini-Douiret. The exact test of population differentiation based on allele frequencies at the 15 loci shows significant P values at 7 loci between Chenini-Douiret and both Sened and Matmata, whereas just 5 loci show significant P values between Sened and Matmata. Comparative analyses between the three Berber groups based on genetic distances show that P values for F(ST) distances are significant between the three Berber groups. Population analysis performed using Structure shows a clear differentiation between these Berber groups, with strong genetic isolation of Chenini-Douiret. These results confirm at the autosomal level the high degree of heterogeneity of Tunisian Berber populations that had been previously reported for uniparental markers.

Exploring the electron transfer pathway in the oxidation of avermectin by CYP107Z13 in Streptomyces ahygroscopicus ZB01.

Directory of Open Access Journals (Sweden)

Mei Li

Full Text Available Streptomyces ahygroscopicus ZB01 can effectively oxidize 4″-OH of avermectin to form 4″-oxo-avermectin. CYP107Z13 is responsible for this site-specific oxidation in ZB01. In the present study, we explored the electron transfer pathway in oxidation of avermectin by CYP107Z13 in ZB01. A putative [3Fe-4S] ferredoxin gene fd68 and two possible NADH-dependent ferredoxin reductase genes fdr18 and fdr28 were cloned from the genomic DNA of ZB01. fd68 gene disruption mutants showed no catalytic activity in oxidation of avermectin to form 4″-oxo-avermectin. To clarify whether FdR18 and FdR28 participate in the electron transfer during avermectin oxidation by CYP107Z13, two whole-cell biocatalytic systems were designed in E. coli BL21 (DE3, with one co-expressing CYP107Z13, Fd68 and FdR18 and the other co-expressing CYP107Z13, Fd68 and FdR28. Both of the two biocatalytic systems were found to be able to mediate the oxidation of avermectin to form 4″-oxo-avermectin. Thus, we propose an electron transfer pathway NADH→FdR18/FdR28→Fd68→CYP107Z13 for oxidation of avermectin to form 4″-oxo-avermectin in ZB01.

Data for 15 autosomal STR markers (Powerplex 16 System) from two Tunisian populations: Kesra (Berber) and Zriba (Arab)

OpenAIRE

Cherni, L; Loueslati Yaâcoubi, B; Pereira, L; Alves, C; Khodjet el Khil, H; Ben Ammar El Gaaied, A; Amorim, A

2005-01-01

Allele frequencies, together with some parameters of forensic interest, for 15 STRs included in the Powerplex 16 System (CSF1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, Penta D, Penta E, TH01, TPO and VWA) were estimated from two samples of unrelated individuals from Tunisia, of different ethnicity: Kesra (Berber) and Zriba (Arab). No deviations from Hardy-Weinberg equilibrium were observed after Bonferroni's correction for the number of loci analysed. Compara...

Investigation into the MgF2-NiF2, CaF2-NiF2, SrF2-NiF2 systems

International Nuclear Information System (INIS)

Ikrami, D.D.; Petrov, S.V.; Fedorov, P.P.; Ol'khovaya, L.A.; Luginina, A.A.; AN SSSR, Moscow. Inst. Fizicheskikh Problem; AN SSSR, Moscow. Inst. Kristallografii)

1984-01-01

Using the methods of differential thermal and X-ray phase analyses the systems MgF 2 -NiF 2 , CaF 2 -NiF 2 , SrF 2 -NiF 2 have been studied. In the system SrF 2 -NiF 2 the only orthorhombic compounds SrNiF 4 (a=14.43; b=3.93; c=5.66 (+-0.01 A)) is formed. SrNiF 4 density constitutes: dsub(X-ray)=4.60+-0.01 g/cm 3 , dsub(exp.)=4.60+-0.03 g/cm 3 . Refraction indices are as follows SrNiF 4 :Ng=1.500; Nsub(m)=1.497; Nsub(p)=1.479. SrNiF 4 magnetic ordering temperature Tsub(N) approximately 100 K

The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.

Science.gov (United States)

Bateman, Alex; Kickhoefer, Valerie

2003-10-16

Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. The TROVE module--Telomerase, Ro and Vault module--is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

Design and manufacturing of 05F-01K instrumented capsule for nuclear fuel irradiation in Hanaro

Energy Technology Data Exchange (ETDEWEB)

Sohn, J. M.; Shin, Y. T.; Park, S. J. (and others)

2007-07-15

An instrumented capsule was developed to be able to measure fuel characteristics, such as fuel temperature, internal pressure of fuel rod, fuel pellet elongation, and neutron flux, etc., during the irradiation test of nuclear fuel in Hanaro. The instrumented capsule(02F-11K) for measuring and monitoring and monitoring fuel centerline temperature and neutron flux was designed and manufactured. It was successfully irradiated in the test hole OR5 of Hanaro from March 14, 2003 to June 1, 2003 (53.84 full power days at 24 MW). In the year of 2004, 3 test fuel rods and the instrumented capsule(03F-05K) were designed and manufactured to measure fuel centerline temperature, internal pressure of fuel rod, and fuel axial deformation during irradiation test. This capsule was irradiated in the test hole OR5 of Hanaro reactor from April 26, 2004 to October 1, 2004 (59.5 EFPD at 24 {approx} 30 MW). The six typed dual instrumented fuel rods, which allow for two characteristics to be measured simultaneously in one fuel rod, have been designed and manufactured to enhance the efficiency of the irradiation test using the instrumented fuel capsule. The 05F-01K instrumented fuel capsule was designed and manufactured for a design verification test of the three dual instrumented fuel rods. The irradiation test of the 05F-01K instrumented fuel capsule will be carried out at the OR5 vertical experimental hole of Hanaro.

The F4/AS01B HIV-1 Vaccine Candidate Is Safe and Immunogenic, But Does Not Show Viral Efficacy in Antiretroviral Therapy-Naive, HIV-1-Infected Adults

Science.gov (United States)

Dinges, Warren; Girard, Pierre-Marie; Podzamczer, Daniel; Brockmeyer, Norbert H.; García, Felipe.; Harrer, Thomas; Lelievre, Jean-Daniel; Frank, Ian; Colin De Verdière, Nathalie; Yeni, Guy-Patrick; Ortega Gonzalez, Enrique; Rubio, Rafael; Clotet Sala, Bonaventura; DeJesus, Edwin; Pérez-Elias, Maria Jesus; Launay, Odile; Pialoux, Gilles; Slim, Jihad; Weiss, Laurence; Bouchaud, Olivier; Felizarta, Franco; Meurer, Anja; Raffi, François; Esser, Stefan; Katlama, Christine; Koletar, Susan L.; Mounzer, Karam; Swindells, Susan; Baxter, John D.; Schneider, Stefan; Chas, Julie; Molina, Jean-Michel; Koutsoukos, Marguerite; Collard, Alix; Bourguignon, Patricia; Roman, François

2016-01-01

Abstract The impact of the investigational human immunodeficiency virus type 1 (HIV-1) F4/AS01B vaccine on HIV-1 viral load (VL) was evaluated in antiretroviral therapy (ART)-naive HIV-1 infected adults. This phase IIb, observer-blind study (NCT01218113), included ART-naive HIV-1 infected adults aged 18 to 55 years. Participants were randomized to receive 2 (F4/AS01B_2 group, N = 64) or 3 (F4/AS01B_3 group, N = 62) doses of F4/AS01B or placebo (control group, N = 64) at weeks 0, 4, and 28. Efficacy (HIV-1 VL, CD4+ T-cell count, ART initiation, and HIV-related clinical events), safety, and immunogenicity (antibody and T-cell responses) were evaluated during 48 weeks. At week 48, based on a mixed model, no statistically significant difference in HIV-1 VL change from baseline was demonstrated between F4/AS01B_2 and control group (0.073 log10 copies/mL [97.5% confidence interval (CI): −0.088; 0.235]), or F4/AS01B_3 and control group (−0.096 log10 copies/mL [97.5% CI: −0.257; 0.065]). No differences between groups were observed in HIV-1 VL change, CD4+ T-cell count, ART initiation, or HIV-related clinical events at intermediate timepoints. Among F4/AS01B recipients, the most frequent solicited symptoms were pain at injection site (252/300 doses), fatigue (137/300 doses), myalgia (105/300 doses), and headache (90/300 doses). Twelve serious adverse events were reported in 6 participants; 1 was considered vaccine-related (F4/AS01B_2 group: angioedema). F4/AS01B induced polyfunctional F4-specific CD4+ T-cells, but had no significant impact on F4-specific CD8+ T-cell and anti-F4 antibody levels. F4/AS01B had a clinically acceptable safety profile, induced F4-specific CD4+ T-cell responses, but did not reduce HIV-1 VL, impact CD4+ T-cells count, delay ART initiation, or prevent HIV-1 related clinical events. PMID:26871794

Simultaneous hyperpolarized ¹³C-pyruvate MRI and ¹⁸F-FDG-PET in cancer (hyperPET)

DEFF Research Database (Denmark)

Borgwardt, Henrik Gutte; Hansen, Adam Espe; Henriksen, Sarah T.

2015-01-01

have named this concept hyper PET. Intravenous injection of the hyperpolarized (13)C-pyruvate results in an increase of (13)C-lactate, (13)C-alanine and (13)C-CO2 ((13)C-HCO3) resonance peaks relative to the tissue, disease and the metabolic state probed. Accordingly, with dynamic nuclear polarization......In this paper we demonstrate, for the first time, the feasibility of a new imaging concept - combined hyperpolarized (13)C-pyruvate magnetic resonance spectroscopic imaging (MRSI) and (18)F-FDG-PET imaging. This procedure was performed in a clinical PET/MRI scanner with a canine cancer patient. We...... (DNP) and use of (13)C-pyruvate it is now possible to directly study the Warburg Effect through the rate of conversion of (13)C-pyruvate to (13)C-lactate. In this study, we combined it with (18)F-FDG-PET that studies uptake of glucose in the cells. A canine cancer patient with a histology verified...

Public Notice: J.F. White Contracting Co. and Massachusetts Department of Transportation, CWA-01-2016-0009

Science.gov (United States)

Notice of Proposed Assessment of Class II Clean Water Act Section 309(g)(2)(B) Administrative Penalties and Opportunity to Comment for J.F. White Contracting Co., Framingham, MA & Massachusetts Department of Transportation, Boston, MA, CWA-01-2016-0009

Labeling of complex molecules with 18F, 13N, and 11C

International Nuclear Information System (INIS)

Brownell, G.L.; Elmaleh, D.R.

1980-01-01

The overall objective during the period covered by this report was to develop a broad spectrum of radiopharmaceuticals labeled with short-lived cyclotron positron emitters, 11 C, 13 N and 18 F. The goals of the program during the last year were: (1) to complete the modular automated system for important precursor production - formaldehyde, methyliodide, cyanide; (2) to perform animal studies with the 18 F-glucose analogues 2FDG and 3FDG and measure the constants for both agents in different animals; and (3) to initiate the development of new fatty acid analogues for the myocardial imaging and metabolism. As part of a collaboration with other groups seeking new agents for myocardium and brain, 9-/sup 123m/Te-telluriumheptadecanoic acid as a myocardial imaging agent was studied. This compound could be used for designing new fatty acid analogues labeled with 11 C and 18 F that stay in the myocardium because of metabolic inhibition

Genetic Polymorphisms of 15 STR Loci within Turkish Student Population Living in Sarajevo, Bosnia and Herzegovina

OpenAIRE

Dogan, Serkan; Kovačević, Lejla; Marjanović, Damir

2013-01-01

Allele frequencies of 15 STRs included in the PowerPlex 16 System (D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, VWA, D8S1179, TPOX and FGA) were calculated from the referent sample of 100 unrelated individuals of both sexes from Turkish student population living in Sarajevo, Bosnia and Herzegovina. Buccal swab, as a source of DNA, was collected from the volunteers from whom the informed consent form was obtained. DNA extraction was performed using...

Analysis of short tandem repeat (STR) polymorphisms by the powerplex 16 system and capillary electrophoresis: application to forensic practice.

OpenAIRE

Okamoto, Osamu; Yamamoto, Yuji; Inagaki, Sachiyo; Yoshitome, Kei; ishikawa, Takaki; Imabayashi, Kiyomi; Miyaishi, Satoru; Ishizu, Hideo

2003-01-01

Allele and genotype frequencies for 15 short tandem repeat (STR) polymorphisms--D3S1358, TH01, D21S11, D18S51, Penta E, D5S818, D13S317, D7S820, D16S539, CSF1PO, Penta D, vWA, D8S1179, TPOX and FGA--in a Japanese population were estimated. No deviations of the observed allele frequency from Hardy-Weinberg equilibrium expectations were found for any of the systems studied. Between 2 new pentanucleotide STR loci, Penta E and Penta D, for which there is only limited data regarding the allelic di...

6 CFR 13.13 - Parties to the hearing.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Parties to the hearing. 13.13 Section 13.13 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.13 Parties to the hearing. (a) The parties to the hearing will be the Defendant and the Authority...

Remaining Sites Verification Package for the 100-F-26:13, 108-F Drain Pipelines. Attchment to Waste Site Reclassification Form 2005-011

International Nuclear Information System (INIS)

Dittmer, L.M.

2008-01-01

The 100-F-26:13 waste site is the network of process sewer pipelines that received effluent from the 108-F Biological Laboratory and discharged it to the 188-F Ash Disposal Area (126-F-1 waste site). The pipelines included one 0.15-m (6-in.)-, two 0.2-m (8-in.)-, and one 0.31-m (12-in.)-diameter vitrified clay pipe segments encased in concrete. In accordance with this evaluation, the verification sampling results support a reclassification of this site to Interim Closed Out. The results of verification sampling demonstrated that residual contaminant concentrations do not preclude any future uses and allow for unrestricted use of shallow zone soils. The results also showed that residual contaminant concentrations are protective of groundwater and the Columbia River

Vaccination Week in the Americas, 2011: an opportunity to assess the routine vaccination program in the Bolivarian Republic of Venezuela.

Science.gov (United States)

Sánchez, Daniel; Sodha, Samir V; Kurtis, Hannah J; Ghisays, Gladys; Wannemuehler, Kathleen A; Danovaro-Holliday, M Carolina; Ropero-Álvarez, Alba María

2015-04-17

Vaccination Week in the Americas (VWA) is an annual initiative in countries and territories of the Americas every April to highlight the work of national expanded programs on immunization (EPI) and increase access to vaccination services for high-risk population groups. In 2011, as part of VWA, Venezuela targeted children aged less than 6 years in 25 priority border municipalities using social mobilization to increase institution-based vaccination. Implementation of social communication activities was decentralized to the local level. We conducted a survey in one border municipality of Venezuela to evaluate the outcome of VWA 2011 and provide a snapshot of the overall performance of the routine EPI at that level. We conducted a coverage survey, using stratified cluster sampling, in the Venezuelan municipality of Bolivar (bordering Colombia) in August 2011. We collected information for children aged 85%, with a few exceptions. Low levels of VWA awareness among caregivers probably contributed to the limited vaccination of eligible children during the VWA activities in Bolivar in 2011. However, vaccine coverage for most EPI vaccines was high. Additionally, high vaccination card availability and high participation in VWA among those caregivers aware of it in 2011 suggest public trust in the EPI program in the municipality. Health authorities have used survey findings to inform changes to the routine EPI and better VWA implementation in subsequent years.

The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins

Directory of Open Access Journals (Sweden)

Bateman Alex

2003-10-01

Full Text Available Abstract Background Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. Results The TROVE module – Telomerase, Ro and Vault module – is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. Conclusions This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

Genetic data for 15 STR loci in a Kadazan-Dusun population from East Malaysia.

Science.gov (United States)

Kee, B P; Lian, L H; Lee, P C; Lai, T X; Chua, K H

2011-04-26

Allele frequencies of 15 short tandem repeat (STR) loci, namely D5S818, D7S820, D13S317, D16S539, TH01, TPOX, Penta D, Penta E, D3S1358, D8S1179, D18S51, D21S11, CSF1PO, vWA, and FGA, were determined for 154 individuals from the Kadazan-Dusun tribe, an indigenous population of East Malaysia. All loci were amplified by polymerase chain reaction, using the Powerplex 16 system. Alleles were typed using a gene analyzer and the Genemapper ID software. Various statistical parameters were calculated and the combined power of discrimination for the 15 loci in the population was calculated as 0.999999999999999. These loci are thus, informative and can be used effectively in forensic and genetic studies of this indigenous population.

Elevated electrochemical performance of (NH4)3AlF6-coated 0.5Li2MnO3·0.5LiNi1/3Co1/3Mn1/3O2 cathode material via a novel wet coating method

International Nuclear Information System (INIS)

Xu, Guofeng; Li, Jianling; Xue, Qingrui; Dai, Yu; Zhou, Hongwei; Wang, Xindong; Kang, Feiyu

2014-01-01

A novel wet method of (NH 4 ) 3 AlF 6 coating was explored to enhance the electrochemical performance of Mn-based solid-solution cathode material 0.5Li 2 MnO 3 ·0.5LiNi 1/3 Co 1/3 Mn 1/3 O 2 . The X-ray powder diffraction patterns show that the coating material is pure-phase (NH 4 ) 3 AlF 6 and both pristine and coated samples can be indexed to hexagonal α-NaFeO 2 layered structure with space group of R-3 m. The field-emission scanning electron microscope images and the energy dispersive X-ray spectroscopy show that (NH 4 ) 3 AlF 6 is successfully coated on the surface of active particle. The (NH 4 ) 3 AlF 6 coated electrodes exhibit improved electrochemical performance, for instance, the initial charge-discharge efficiency was promoted by 5% (NH 4 ) 3 AlF 6 coating, the 1 wt.% and 3 wt.% coated electrodes deliver elevated cycling ability which is ascribed to the lower resistance between electrode and electrolyte as indicated by AC impedance measurement at different cycles. In addition, the coated-electrodes also give enhanced rate capability particularly for 1 wt.% NAF-coated electrode performing surprising capacity of 143.4 mAh g −1 at 5 C higher than that of 109.4 mAh g −1 for pristine electrode. Furthermore, the 1 wt.% NAF-coated electrode also shows improved cycle and rate performance at 55°C

Experimental study of radiative pion capture on 13C, 20Ne, 90Zr, 19F and 12C

International Nuclear Information System (INIS)

Martoff, C.J.

1980-11-01

Photon spectra for 50 13 C, 19 F, 20 Ne, and 90 Zr. The e + e - pair spectrometer system used has resolution 850 keV fwhm and photon detection efficiency 5 x 10 -6 . The total radiative capture branching ratios measured are 13 C (1.66 +- 0.25)%, 19 F (2.40 +- 0.48)%, 20 Ne (1.60 +- 0.24)%, and 90 Zr (2.1 +- 0.5)%. The partial radiative capture branching ratios to four bound states and two resonances in 20 F, and two bound states and three resonances in 13 B have also been measured. The branching ratio for 13 C(π - ,γ) 13 B g.s. is (6.1 +- 1.2) x 10 -4 . Comparison of this result with the beta decay rate of 13 B shows that (84 +- 16)% of the pion capture amplitude is accounted for by the Gamow-Teller matrix element. Further analysis suggests that much of the remaining strength is E2. The measured branching ratios to resonant states in 13 C(π - ,γ) 13 B are shown to be in agreement with detailed shell model calculations. The total single-particle strength in these transitions is shown to be approximately half as large as that of the T = 3/2 part of the E1 photoresonance (the Giant Dipole Resonance) in 13 C. The branching ratio for 20 Ne(π - ,γ) 20 F (T = 1, J/sup π/ = 1 + , E/sub x/ = 1.06 MeV) is 0.91 +- 0.52).10 -4 . Comparison with the electroexcitation of the analog giant M1 state in 20 Ne (11.24 MeV) shows that the M1 transition amplitude is less than (46 +- 14)% Gamow-Teller. This result is in agreement with detailed shell model calculations of the M1 transition. The photon spectrum for radiative pion capture from flight (reaction 12 C(π + T = 44 MeV, γ at 90 0 )) has been measured. 13 figures, 12 tables

13 CFR 315.13 - Audit and examination.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Audit and examination. 315.13 Section 315.13 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE... books, documents, papers, and records of a Firm, TAAC or other recipient of Adjustment Assistance...

12 CFR 708a.13 - Voting guidelines.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Voting guidelines. 708a.13 Section 708a.13... INSURED CREDIT UNIONS TO MUTUAL SAVINGS BANKS § 708a.13 Voting guidelines. A converting credit union must conduct its member vote on conversion in a fair and legal manner. NCUA provides the following guidelines...

RSS SSM/I OCEAN PRODUCT GRIDS DAILY FROM DMSP F13 NETCDF V7

Data.gov (United States)

National Aeronautics and Space Administration — The RSS SSM/I Ocean Product Grids Daily from DMSP F13 netCDF dataset is part of the collection of Special Sensor Microwave/Imager (SSM/I) and Special Sensor...

[Comparison of the grafting technique in treatment of thoracolumbar burst fractures:transpedicular intracorporeal versus posterolateral].

Science.gov (United States)

Li, Li; Shi, Ya-Min; Hou, Shu-Xun; Wang, Hua-Dong; Guo, Ji-Dong

2011-02-01

To retrospectively investigate the outcome of transpedicular intracorporeal grafting and posterolateral grafting in treatment of thoracolumbar burst fractures. Forty-six patients treated with transpedicular intracorporeal grafting from January 1999 to December 2009 and followed up for 19-119 months (average 67 ± 13 months) were reviewed retrospectively, and were compared with 18 patients who had underwent posterolateral fusion during the same period through radiographic analysis. Radiographic measurements included Cobb angle, vertebral wedge angle (VWA), ratio between anterior and posterior vertebral height (APHR), upper inter-vertebral angle, lower inter-vertebral angle on X-ray, CT and MRI. In transpedicular intracorporeal grafting group, the VWA was corrected from 27.2° ± 6.5° to 7.0° ± 3.0° and the APHR from (53.3 ± 11.8)% to (92.3 ± 2.4)%. In posterolateral fusion group, the VWA was corrected from 23.9° ± 4.4° to 8.8° ± 2.1° and the APHR from (60.7 ± 10.0)% to (88.5 ± 3.3)%. Transpedicular intracorporeal grafting group showed better postoperative correction results than posterolateral fusion group (P < 0.05), and had less loss of correction of Cobb angle, VWA and APHR at final follow-up (P < 0.05). The transpedicular intracorporeal grafting can improve injured vertebral body morphology recovery better than posterolateral bone grafting, but can not prevent the late loss of correction after implant removal.

Post-irradiation examinations of inert matrix nitride fuel irradiated in JMTR (01F-51A capsule)

International Nuclear Information System (INIS)

Iwai, Takashi; Nakajima, Kunihisa; Kikuchi, Hironobu; Honda, Junichi; Hatakeyama, Yuichi; Ono, Katsuto; Matsui, Hiroki; Arai, Yasuo

2007-03-01

A plutonium nitride fuel pin containing inert matrix such as ZrN and TiN was encapsulated in 01F-51A and irradiated in JMTR. Minor actinides are surrogated by plutonium. Average linear powers and burnups were 408W/cm, 30000MWd/t(Zr+Pu) [132000MWd/t-Pu] for (Zr,Pu)N and 355W/cm, 38000MWd/t(Ti+Pu) [153000MWd/t-Pu] for (TiN,PuN). The irradiated capsule was transported to Reactor Fuel Examination Facility and subjected to non-destructive and destructive post irradiation examinations. Any failure was not observed in the irradiated fuel pin. Very low fission gas release rate of about 1.6% was measured. The inner surface of cladding tube did not show any signs of chemical interaction with fuel pellet. (author)

13 CFR 305.13 - Contract change orders.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Contract change orders. 305.13 Section 305.13 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE... all such work will be at the Recipient's risk until EDA completes its review. ...

HOXB13 promotes androgen independent growth of LNCaP prostate cancer cells by the activation of E2F signaling

Directory of Open Access Journals (Sweden)

Choi Chan

2010-05-01

Full Text Available Abstract Background Androgen signaling plays a critical role in the development of prostate cancer and its progression. However, androgen-independent prostate cancer cells emerge after hormone ablation therapy, resulting in significant clinical problems. We have previously demonstrated that the HOXB13 homeodomain protein functions as a prostate cancer cell growth suppressor by inhibiting androgen-mediated signals. However, the role of the HOXB13 in androgen-independent growth of prostate cancer cells remains unexplained. Results In this report, we first demonstrated that HOXB13 was highly overexpressed in hormone-refractory tumors compared to tumors without prostate-specific antigen after initial treatment. Functionally, in an androgen-free environment minimal induction of HOXB13 in LNCaP prostate cancer cells, to the level of the normal prostate, markedly promoted cell proliferation while suppression inhibited cell proliferation. The HOXB13-mediated cell growth promotion in the absence of androgen, appears to be mainly accomplished through the activation of RB-E2F signaling by inhibiting the expression of the p21waf tumor suppressor. Indeed, forced expression of HOXB13 dramatically decreased expression of p21waf; this inhibition largely affected HOXB13-mediated promotion of E2F signaling. Conclusions Taken together, the results of this study demonstrated the presence of a novel pathway that helps understand androgen-independent survival of prostate cancer cells. These findings suggest that upregulation of HOXB13 is associated with an additive growth advantage of prostate cancer cells in the absence of or low androgen concentrations, by the regulation of p21-mediated E2F signaling.

Apelin-13 inhibits large-conductance Ca2+-activated K+ channels in cerebral artery smooth muscle cells via a PI3-kinase dependent mechanism.

Directory of Open Access Journals (Sweden)

Amit Modgil

Full Text Available Apelin-13 causes vasoconstriction by acting directly on APJ receptors in vascular smooth muscle (VSM cells; however, the ionic mechanisms underlying this action at the cellular level remain unclear. Large-conductance Ca(2+-activated K(+ (BKCa channels in VSM cells are critical regulators of membrane potential and vascular tone. In the present study, we examined the effect of apelin-13 on BK(Ca channel activity in VSM cells, freshly isolated from rat middle cerebral arteries. In whole-cell patch clamp mode, apelin-13 (0.001-1 μM caused concentration-dependent inhibition of BK(Ca in VSM cells. Apelin-13 (0.1 µM significantly decreased BK(Ca current density from 71.25 ± 8.14 pA/pF to 44.52 ± 7.10 pA/pF (n=14 cells, P<0.05. This inhibitory effect of apelin-13 was confirmed by single channel recording in cell-attached patches, in which extracellular application of apelin-13 (0.1 µM decreased the open-state probability (NPo of BK(Ca channels in freshly isolated VSM cells. However, in inside-out patches, extracellular application of apelin-13 (0.1 µM did not alter the NPo of BK(Ca channels, suggesting that the inhibitory effect of apelin-13 on BKCa is not mediated by a direct action on BK(Ca. In whole cell patches, pretreatment of VSM cells with LY-294002, a PI3-kinase inhibitor, markedly attenuated the apelin-13-induced decrease in BK(Ca current density. In addition, treatment of arteries with apelin-13 (0.1 µM significantly increased the ratio of phosphorylated-Akt/total Akt, indicating that apelin-13 significantly increases PI3-kinase activity. Taken together, the data suggest that apelin-13 inhibits BK(Ca channel via a PI3-kinase-dependent signaling pathway in cerebral artery VSM cells, which may contribute to its regulatory action in the control of vascular tone.

2018-05-05T13:50:01Z https://www.ajol.info/index.php/all/oai oai:ojs ...

African Journals Online (AJOL)

article/73011 2018-05-05T13:50:01Z pelj:ART The Right to Dignity and Restorative Justice in Schools Reyneke, M A retributive and punitive approach is normally adopted in dealing with misbehaviour in South African schools. Despite the legal ...

Population genetic study for 24 STR loci and Y indel (GlobalFiler™ PCR Amplification kit and PowerPlex® Fusion system) in 1000 Korean individuals.

Science.gov (United States)

Park, Hyun-Chul; Kim, Kicheol; Nam, Younhyoung; Park, Jihye; Lee, Jinmyung; Lee, Hyehyeon; Kwon, Hansol; Jin, Hanjun; Kim, Wook; Kim, Won; Lim, Sikeun

2016-07-01

Allele frequencies for 23 autosomal short tandem repeat loci (D3S1358, vWA, D16S539, CSF1PO, TPOX, D8S1179, D21S11, D18S51, TH01, FGA, D5S818, D13S317, D7S820, D2S441, D19S433, D22S1045, D10S1248, D1S1656, D12S391, D2S1338, SE33, Penta D, Penta E), 1 Y-chromosome short tandem repeat locus (DYS391) and Y indel were obtained from 1000 unrelated individuals of the Korean population. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

The combination of 13N-ammonia and 18F-FDG whole-body PET/CT on the same day for diagnosis of advanced prostate cancer

Science.gov (United States)

Yi, Chang; Yu, Donglan; Shi, Xinchong; Luo, Ganhua; He, Qiao; Zhang, Xuezhen

2016-01-01

Purpose The aim of the study was to evaluate the efficacy of 13N-ammonia and 18F-fluorodeoxyglucose (18F-FDG) PET performed on the same day in the detection of advanced prostate cancer (PC) and its metastases. Patients and methods Twenty-six patients with high-risk PC [Gleason score 8–10 or prostate-specific antigen (PSA)>20 ng/ml or clinical tumor extension≥T2c] were recruited into the study. 13N-Ammonia and 18F-FDG PET/CT were performed on the same day (18F-FDG followed ammonia, with an interval of a minimum of 2 h). Lesions were interpreted as positive, negative, or equivocal. Patient-based and field-based performance characteristics for both imaging techniques were reported. Results There was significant correlation between 13N-ammonia and 18F-FDG PET/CT in the detection of primary PC (κ=0.425, P=0.001) and no significant difference in sensitivity (60.2 vs. 54.5%) and specificity (100 vs. 83.3%). The maximum standard uptake values and corresponding target-to-background ratio values of the concordantly positive lesions in prostate glands in the two studies did not differ significantly (P=0.124 and 0.075, respectively). The sensitivity and specificity of PET imaging using 13N-ammonia for lymph node metastases were 77.5 and 96.3%, respectively, whereas the values were 75 and 44.4% using 18F-FDG. The two modalities were highly correlated with respect to the detection of lymph nodes and bone metastases. Conclusion The concordance between the two imaging modalities suggests a clinical impact of 13N-ammonia PET/CT in advanced PC patients as well as of 18F-FDG. 13N-Ammonia is a useful PET tracer and a complement to 18F-FDG for detecting primary focus and distant metastases in PC. The combination of these two tracers on the same day can accurately detect advanced PC. PMID:26588068

6 CFR 13.6 - Prerequisites for issuing a Complaint.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Prerequisites for issuing a Complaint. 13.6 Section 13.6 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.6 Prerequisites for issuing a Complaint. (a) The Reviewing Official may issue a...

26 CFR 13.0-13.3 - [Reserved

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 14 2010-04-01 2010-04-01 false [Reserved] 13.0-13.3 Section 13.0-13.3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) TEMPORARY INCOME TAX REGULATIONS UNDER THE TAX REFORM ACT OF 1969 §§ 13.0-13.3 [Reserved] ...

Interlaboratory Study (ILS) for F 548-01, The Standard Test Method for Intensity of Scratches on Aerospace Transparent Plastics

National Research Council Canada - National Science Library

Pinkus, Alan

2003-01-01

...) as outlined in ASTM E 691. This report, which conforms to the ILS reporting format required by ASTM, describes the study that was conducted for ASTM test standard F 548-01, Intensity of Scratches on Aerospace Transparent Plastics...

Irradiation test plan of instrumented capsule(05F-01K) for nuclear fuel irradiation in Hanaro (Revision 1)

Energy Technology Data Exchange (ETDEWEB)

Sohn, Jae Min; Kim, B. G.; Choi, M. H. (and others)

2006-09-15

An instrumented capsule was developed to be able to measure fuel characteristics, such as fuel temperature, internal pressure of fuel rod, fuel pellet elongation, and neutron flux, etc., during the irradiation test of nuclear fuel in HANARO. The instrumented capsule for measuring and monitoring fuel centerline temperature and neutron flux was designed and manufactured. And then, to verify the design of the instrumented capsule in the test hole, it was successfully irradiated in the test hole of HANARO from March 14, 2003 to June 1, 2003 (53.84 full power days at 24 MW). In the year of 2004, 3 test fuel rods and the 03F-05K instrumented fuel capsule were designed and fabricated to measure fuel centerline temperature, internal pressure of fuel rod, and fuel axial deformation during irradiation test. Now, this capsule was successfully irradiated in the test hole OR5 of HANARO reactor from April 27, 2004 to October 1, 2004 (59.5 full power days at 24-30 MW). The capsule and fuel rods have been be dismantled and fuel rods have been examined at the hot cell of IMEF. The instrumented fuel capsule (05F-01K) was designed and manufactured for a design verification test of the dual instrumented fuel rods. The irradiation test of the 05F-01K instrumented fuel capsule will be carried out at the OR5 vertical experimental hole of HANARO.

2018-03-16T01:44:13Z https://www.ajol.info/index.php/all/oai oai:ojs ...

African Journals Online (AJOL)

article/78898 2018-03-16T01:44:13Z ajpherd:ART Eating disorders among university student-athletes Van Zyl, Y Surujlal, J Dhurup, M Eating disorders among athletes is an alarming issue, much deserving of the interest it has enthused among ...

Academic Training: 3rd Term - 01 April - 30 June 2005

CERN Multimedia

Françoise Benz

2005-01-01

2004 - 2005 ACADEMIC TRAINING PROGRAMME 3rd Term - 01 April - 30 June 2005 REGULAR LECTURE PROGRAMME Monte Carlo generators fot the LHC by T. Sjostrand / CERN-PH 4, 5, 6, 7 April The LHC machine experiment interface by S. Tapprogge / Univ. Gutenberg, Mainz, D R. Assmann, CERN-AB, E. Tsesmelis and D. Macina / CERN-TS 18, 19, 20, 21, 22 April Cosmology for particle physicists by S. Carroll / Univ. of Chicago, USA 9, 10, 11, 12, 13 May The ITER projects: technological challenges by P. Bruzzone / EPFL CRPP, Zürich, CH J. Lister / EPFL CRPP, Lausanne, CH 30, 31 May, 1, 2, 3 June String theory by C. Johnson / Univ. of Southern California, USA 6, 7, 8, 9, 10 June Small may be beautiful By M. Davier / LAL, Orsay, F. T. Soldner / ILL, Grenoble, F. 13, 14, 15, 16, 17 June Climate change and challenges for the environment by C. Schluchter / Univ. Bern. CH 20, 21, 22 June LECTURE SERIES FOR POSTGRADUATE STUDENTS Particle detectors - principles and techniques by C. Joram, L. Ropelewski, M. Moll, C. ...

Preparation of Sr7Mn4O13F2 by the topotactic reduction and subsequent fluorination of Sr7Mn4O15.

Science.gov (United States)

Saratovsky, Ian; Lockett, Michelle A; Rees, Nicholas H; Hayward, Michael A

2008-06-16

The topotactic reduction and subsequent fluorination of Sr7Mn4O15 yields a phase of composition Sr7Mn4O13F2. Characterization of this phase utilizing powder neutron diffraction and 19F NMR shows that the fluoride ions are located on a single anion site, the same crystallographic site that is vacant in the reduced intermediate Sr7Mn4O13.

Long-term follow-up of HIV-1-infected adults who received the F4/AS01B HIV-1 vaccine candidate in two randomised controlled trials.

Science.gov (United States)

Harrer, Thomas; Dinges, Warren; Roman, François

2018-05-03

This Phase I/II, open, long-term follow-up study was conducted in antiretroviral therapy (ART)-naïve (N = 212) and ART-treated (N = 19) human immunodeficiency virus 1 (HIV-1)-infected adults, who received an HIV-1 investigational vaccine (F4/AS01 B ) or placebo in two previous studies (NCT00814762 and NCT01218113). After a minimum of two years and a maximum of four years of follow-up post-vaccination per patient, no significant differences were observed between F4/AS01 B and placebo groups in terms of viral load, CD4 + T-cell count and incidence of specific clinical events. Vaccine-induced polyfunctional CD4 + T-cells persisted up to study end and no relevant vaccine-related safety events were reported in F4/AS01 B groups. This study has been registered at ClinicalTrials.gov (NCT01092611). Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Stenhammer, Wilhelm. sinfonien Nr. 1 F-Dur und Nr. 2 g-Moll op. 34, Excelsior! op. 13, Serenade F-Dur op. 31. Sinfonieorchester Göteborg, Neeme Järvi / Andreas K. W. Meyer

Index Scriptorium Estoniae

Meyer, Andreas K. W.

1995-01-01

Uuest heliplaadist "Stenhammer, Wilhelm. sinfonien Nr. 1 F-Dur und Nr. 2 g-Moll op. 34, Excelsior! op. 13, Serenade F-Dur op. 31. Sinfonieorchester Göteborg, Neeme Järvi". DG 2 CD 445857-2 (WD: 138'37")

Drug-resistant molecular mechanism of CRF01_AE HIV-1 protease due to V82F mutation

Science.gov (United States)

Liu, Xiaoqing; Xiu, Zhilong; Hao, Ce

2009-05-01

Human immunodeficiency virus type 1 protease (HIV-1 PR) is one of the major targets of anti-AIDS drug discovery. The circulating recombinant form 01 A/E (CRF01_AE, abbreviated AE) subtype is one of the most common HIV-1 subtypes, which is infecting more humans and is expanding rapidly throughout the world. It is, therefore, necessary to develop inhibitors against subtype AE HIV-1 PR. In this work, we have performed computer simulation of subtype AE HIV-1 PR with the drugs lopinavir (LPV) and nelfinavir (NFV), and examined the mechanism of resistance of the V82F mutation of this protease against LPV both structurally and energetically. The V82F mutation at the active site results in a conformational change of 79's loop region and displacement of LPV from its proper binding site, and these changes lead to rotation of the side-chains of residues D25 and I50'. Consequently, the conformation of the binding cavity is deformed asymmetrically and some interactions between PR and LPV are destroyed. Additionally, by comparing the interactive mechanisms of LPV and NFV with HIV-1 PR we discovered that the presence of a dodecahydroisoquinoline ring at the P1' subsite, a [2-(2,6-dimethylphenoxy)acetyl]amino group at the P2' subsite, and an N2 atom at the P2 subsite could improve the binding affinity of the drug with AE HIV-1 PR. These findings are helpful for promising drug design.

34 CFR 34.13 - Conduct of a hearing.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Conduct of a hearing. 34.13 Section 34.13 Education Office of the Secretary, Department of Education ADMINISTRATIVE WAGE GARNISHMENT § 34.13 Conduct of a... extension of time in order to submit specific relevant evidence that you identify to us in the request; or...

Identifikasi bite marks dengan ekstraksi DNA metode Chelex (Bite marks identification with Chelex methods in DNA extraction

Directory of Open Access Journals (Sweden)

Imelda Kristina Sutrisno

2013-06-01

Full Text Available Background: In the case of crime often encountered evidence in bite marks form that was found on the victim’s body. Generally, bitemarks identification use standard techniques that compare the interpretation picture with the tooth model of suspected person. However, sometimes the techniques do not obtain accurate results. Therefore another technique is needed to support the identification process,such as DNA analysis that use the remaining epithelium attached in saliva to identify the DNA of the suspected person. In this processes a limited DNA material could be met, not only less in quantity but also less in quality. Chelex known as one of an effective DNA extraction method in DNA forensic case is needed to overcome this problem. Purpose: The study was aimed to examine the use of Chelex as DNA extraction method on a bitemarks sample models. Methods: The blood and bitemarks of 5 persons with were taken. The DNA of each subject was exctracted with Chelex and quantified the quantity with UV Spechtrophotometer. The DNA results was amplified by PCR at locus vWA and TH01 then vizualised by electrophoresis. Results: The electrophoresis’s results showed band at locus vWA and TH01 for blood sample and bite marks with no significant differences. Conclusion: The study showed that Chelex method could be use to extract DNA from bitemarks.Latar belakang: Dalam kasus kejahatan sering dijumpai bukti dalam bentuk bekas gigitan (bitemarks yang ditemukan pada tubuh korban. Umumnya, untuk mengidentifikasi bite marks menggunakan teknik standar yaitu membandingkan foto interpretasi dengan model gigi dari orang yang dicurigai. Namun demikian teknik ini terkadang tidak mendapatkan hasil yang akurat, sehingga diperlukan teknik lain untuk menunjang keberhasilan proses identifikasi pelaku, yakni melalui analisis DNA bitemarks, yang diperoleh dari saliva yang mengandung sisa epitel tersangka pelaku. Sampel DNA yang berasal dari bitemarks umumnya terbatas, tidak hanya

Chilean experience in production of 18F-FDG from 18F in a reactor

International Nuclear Information System (INIS)

Chandia, M.; Godoy, N.; Errazu, X.; Hernandez; Figols, M.; Firnau, G.; Tronsoco, F.

2000-01-01

18 F-FDG (fluorine-deoxy-D-glucose) is an important and useful radiopharmaceutical for imaging and study of myocardial viability. Usually cyclotron-produced 18 F is used to label 18 F-FDG. The availability of a 5 MW Nuclear Reactor in Chile and the absence of a quality cyclotron to produce 18 F required that we developed a method in order to obtain suitable 18 F to label 18 F-FDG using the facilities we have at the Nuclear Center of La Reina, Chilean Nuclear Energy Commission. The nuclear reactions involved are: 6 Li(n,aα) 3 H and 16 O( 3 H,n) 18 F. Enriched Li 2 CO 3 ( 6 Li = 95 %) was irradiated in a 5 MW swimming pool type nuclear reactor with a neutron flux of 5. 7 x 10 13 n cm -2 s -1 for 4 hours. The irradiated Li 2 CO 3 was dissolved in H 2 SO 4 (1:1) and distilled as trimethylsilyl( 18 F)fluoride ( 18 F-TMS). The labelling of the sugar was carried out using the method described by Hamacker. The 18 F-TMS was trapped in a solution of acetonitrile, water, potassium carbonate, and kriptofix and hydrolysed to form 18 F fluoride. The nucleophilic complex reacts with 1,3,4,6, tetra-O-acetyl- 2-O-trifluoromethanesulfonyl-bβ-D-mannopyranose. The acetylated carbohydrate by acid hydrolysis produces 18 F-FDG. The final product was purified using an ion retarding resin (AG11-A8) and a system two Sep Pak Plus: Alumina and C-18 cartridge and sterilised by Millipore 0.22 μm filter. The 18 F-FDG was obtained in an apyrogenic and sterile solution. The 18 F radionuclide purity was higher than 99.9% and the radiochemical purity ofthe 18 F-FDG obtained was over than 99%. Residual 3 H content was as low as 20 (Bq 3 H/MBq 18 F-FDG.). The yield of the process 18 F-FDG was 13.2 %. (authors)

The Aerodynamic Characteristics in Pitch of a 1/15-Scale Model of the Grumman F11F-1 Airplane at Mach Numbers of 1.41, 1.61, and 2.01, TED No. NACA DE 390

Science.gov (United States)

Driver, Cornelius

1956-01-01

Tests have been made in the Langley 4- by 4-foot supersonic pressure tunnel at Mach numbers of 1.41, 1.61, and 2.01 to determine the static longitudinal stability and control characteristics of various arrangements of the Grumman F11F-1 airplane. Tests were made of the complete model and various combinations of its component parts and, in addition, the effects of various body modifications, a revised vertical tail, and wing fences on the longitudinal characteristics were determined. The results indicate that for a horizontal-tail incidence of -10 deg the trim lift coefficient varied from 0.29 at a Mach number of 1.61 to 0.23 at a Mach number of 2.01 with a corresponding decrease in lift-drag trim from 3.72 to 3.15. Stick-position instability was indicated in the low-supersonic-speed range. A photographic-type nose modification resulted in slightly higher values of minimum drag coefficient but did not significantly affect the static stability or lift-curve slope. The minimum drag coefficient for the complete model with the production nose remained essentially constant at 0.047 throughout the Mach number range investigated.

NCBI nr-aa BLAST: CBRC-AGAM-02-0067 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-AGAM-02-0067 ref|YP_001276495.1| VWA containing CoxE family protein [Roseiflex...us sp. RS-1] gb|ABQ90545.1| VWA containing CoxE family protein [Roseiflexus sp. RS-1] YP_001276495.1 3.1 23% ...

Population studies on two native Mongolian population groups in China using STR loci.

Science.gov (United States)

Su, Xiulan; Li, Dongxia; Lifu, Shuping Liu Bi; Yun, Peiyu Wang Tuoya Wu; Yun, Sheng

2004-05-10

The allelic distribution of nine short tandem repeats (STRs) loci (vWA, FGA, PentaE, D3S1358, D13S317, D5S818, D6S1043, D2S1772 and D7S3048) was examined in 286 Ximeng-Mongolian and 293 Wumeng-Mongolian unrelated individuals living in the Inner Mongolia province, PR China.

Biogas Production from Water Hyacinth (Eichhornia Crassipes): The Effect of F/M Ratio

Science.gov (United States)

Nugraha, W. D.; Syafrudin; Pradita, L. L.; Matin, H. H. A.; Budiyono

2018-05-01

Distribution of water hyacinth (Eichhornia crassipes), generally considered as a water weed, that has been a problem which can harm the environment, irrigation system, and agriculture. However water hyacinth can be used in biogas production because it has large enough amount of hemicellulose contents. The purpose of this study was to know the effect of F/M ratio to biogas production from water hyacinth waste with Liquid Anaerobic Digestion (LAD) method. A series of laboratory experiments using biodigester were performed in batch anaerobic operation at room temperature. F/M ratio that used in each reactor was 39.76, 20.03, 13.32, and 10.01. Degradation process was done in 60 days. The result showed that F/M ratio effects to the biogas production. The best performance of biogas production from this research will be obtained if F/M ratio is in the range of 10.01-20.03 (correspond to 25%-50% of rumen fluid) with water hyacinth as the main substrate.

7 CFR 959.13 - Container.

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2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Container. 959.13 Section 959.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 959.13 Container. Container means a box, bag, crate, hamper, basket...

7 CFR 966.13 - Container.

Science.gov (United States)

2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Container. 966.13 Section 966.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 966.13 Container. Container means a box, bag, crate, hamper, basket...

6 CFR 13.4 - Investigation.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Investigation. 13.4 Section 13.4 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.4 Investigation. (a) If an Investigating Official concludes that a subpoena pursuant to the Authority conferred by...

7 CFR 1230.13 - Market.

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2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Market. 1230.13 Section 1230.13 Agriculture... CONSUMER INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.13 Market. Market means to sell, slaughter for sale, or otherwise dispose of a porcine animal in commerce. ...

15 CFR 806.13 - Miscellaneous.

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2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Miscellaneous. 806.13 Section 806.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF ECONOMIC ANALYSIS, DEPARTMENT OF COMMERCE DIRECT INVESTMENT SURVEYS § 806.13 Miscellaneous. (a) Accounting...

6 CFR 13.7 - Complaint.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Complaint. 13.7 Section 13.7 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.7 Complaint. (a) On or after the date the Department of Justice approves the issuance of a Complaint in accordance...

6 CFR 13.47 - Limitations.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Limitations. 13.47 Section 13.47 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.47 Limitations. (a) The notice of hearing with respect to a Claim or Statement must be served in the manner...

6 CFR 13.29 - Sanctions.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Sanctions. 13.29 Section 13.29 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.29 Sanctions. (a) The ALJ may sanction a Person, including any party or Representative, for: (1) Failing to comply with...

10 CFR 810.13 - Reports.

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2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Reports. 810.13 Section 810.13 Energy DEPARTMENT OF ENERGY ASSISTANCE TO FOREIGN ATOMIC ENERGY ACTIVITIES § 810.13 Reports. (a) Any person who has received a specific... report containing the following information: (1) The name, address, and citizenship of the person...

Synthesis of n.c.a. 18F-fluorinated NMDA- and D4-receptor ligands via [18F]fluorobenzenes

International Nuclear Information System (INIS)

Ludwig, T.

2005-11-01

In this thesis new strategies were developed and evaluated for the no-carrier-added (n.c.a.) 18 F-labelling of receptor ligands as radiodiagnostics for characterization of brain receptors using positron-emission-tomography (PET). Special emphasis was placed on the synthesis of n.c.a. (±)-3-(4-hydroxy-4-(4-[ 18 F]fluorophenyl)-piperidin-l-yl)chroman-4,7-diol, a ligand with high affinity for the NR2B subtype of NMDA receptors and n.c.a. (3-(4-[ 18 F]fluorphenoxy)propyl)-(2-(4-tolylphenoxy)ethyl)amine ([ 18 F]FPTEA) a dopamine D 4 receptor ligand. In order to synthesize n.c.a. (±)-3-(4-hydroxy-4-(4-[ 18 F]fluorophenyl)-piperidin-l-yl)chroman-4,7-diol the 18 F-fluoroarylation method via metallorganic intermediates was modified and improved. The suitability of the organometallic 18 F-fluoroarylation agents was proven with several model compounds. High radiochemical yields of 20-30% were obtained also with piperidinone-derivatives. The preparation of a suitable precursor for the synthesis of the NMDA receptor ligand, however, could not be achieved by synthesis of appropriate 1,3-dioxolane protected piperidinone derivatives. Further, the synthesis of n.c.a. ([ 18 F]fluoroaryloxy)alkylamines via n.c.a. 4-[ 18 F]fluorophenol was developed and evaluated. The synthesis of n.c.a. [ 18 F]fluoroarylethers with corresponding model compounds was optimized and led to a radiochemical yield of 25-60%, depending on the alkylhalide used. The preparation of n.c.a. 1-(3-bromopropoxy)-4-[ 18 F]fluorobenzene proved advantageous in comparison to direct use of 4-[ 18 ]fluorophenol for coupling with a corresponding N-protected precursor for the synthesis of n.c.a. [ 18 F]FPTEA. With regard to the radiochemical yields and the loss of activity during the synthesis and isolation of n.c.a. 4-[ 18 F]fluorophenol and n.c.a. 1-(3-bromopropoxy)-4-[ 18 F]fluorobenzene, [ 18 F]FPTEA was obtained by reaction with 2-(4-tolyloxy)ethylamine in radiochemical yields of about 25-30% in ethanol or 2-butanone

Neutron spectra due 13N production in a PET cyclotron

International Nuclear Information System (INIS)

Benavente, J.A.; Vega-Carrillo, H.R.; Lacerda, M.A.S.; Fonseca, T.C.F.; Faria, F.P.; Silva, T.A. da

2015-01-01

Monte Carlo and experimental methods have been used to characterize the neutron radiation field around PET (Positron Emission Tomography) cyclotrons. In this work, the Monte Carlo code MCNPX was used to estimate the neutron spectra, the neutron fluence rates and the ambient dose equivalent (H*(10)) in seven locations around a PET cyclotron during 13 N production. In order to validate these calculations, H*(10) was measured in three sites and were compared with the calculated doses. All the spectra have two peaks, one above 0.1 MeV due to the evaporation neutrons and another in the thermal region due to the room-return effects. Despite the relatively large difference between the measured and calculated H*(10) for one point, the agreement was considered good, compared with that obtained for 18 F production in a previous work. - Highlights: • MCNPX code was used to estimate the neutron spectra in a PET cyclotron. • Neutrons were estimated when 13 N is produced. • Neutron spectra show evaporation and room-return neutrons. • Calculated H*(10) were compared with measured H*(10)

Gene : CBRC-FCAT-01-0220 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-FCAT-01-0220 Novel UN C UNKNOWN CED7_CAEEL 0.24 25% ref|YP_026082.1| ATP synthase F0 subunit 6 [Steiner...nema carpocapsae] gb|AAT00525.1| ATP synthase F0 subunit 6 [Steinernema carpocapsae

29 CFR 516.13 - Livestock auction employees exempt from overtime pay requirements under section 13(b)(13) of the...

Science.gov (United States)

2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Livestock auction employees exempt from overtime pay....13 Livestock auction employees exempt from overtime pay requirements under section 13(b)(13) of the... employee is employed both in agriculture and in connection with livestock auction operations: (a) The total...

6 CFR 13.21 - Discovery.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Discovery. 13.21 Section 13.21 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) In general. (1) The following types of discovery are authorized: (i) Requests for production of...

14 CFR 13.220 - Discovery.

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2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Discovery. 13.220 Section 13.220... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.220 Discovery. (a) Initiation of discovery. Any party may initiate discovery described in this section, without the consent or...

Heterotic studies and inbreeding depression in f/sub 2/populations of upland cotton

International Nuclear Information System (INIS)

Panni, M.K.

2012-01-01

To study the genetic potential, heterotic effects and inbreeding depression, 8 X 8 F/sub 2/diallel populations with parental lines of upland cotton were grown during crop season 2010 in a randomized complete block design at Khyber Pakhtunkhwa Agricultural University Peshawar, Pakistan. Highly significant ( p = 0.01 ) variations were noticed among parental lines and F/sub 2/ populations for all the traits. According to genotypes mean performance for various traits, plant height varied from 101.60 to 126.30 cm and 98.60 to 140.60 cm, bolls plant/sup -1/ (12.87 to 19.53; 12.13 to 22.60), boll weight (3.80 to 5.01 g; 3.04 to 5.38 g) and seed cotton yield plant/sup -1/ varied from 55.74 to 85.47 g and 45.57 to 96.05 g in parental cultivars and their F/sub 2/ populations, respectively. However, 12 and 7 F/sub 2/ populations manifested significant heterosis over mid and better parents for plant height, 7 and 3 for bolls plant/sup -1/, 13 and 9 for boll weight and 13 and 5 F/sub 2/ populations for seed cotton yield plant/sup -1/, respectively. F/sub 2/ populations i.e. CIM-554 X CIM-473, CIM-554 X CIM-499, CIM-496 X SLH-284, CIM-473 X CIM-446 and CIM-554 X SLH-284 with low mean values for plant height performed better and manifested highly significant heterotic values over mid and better parents for bolls per plant, boll weight and seed cotton yield. By comparing F/sub 2/ mean values with F/sub 1/s, inbreeding depression was observed for plant height (0.66 to 23. 99%), bolls per plant (5.00 to 63.16%), boll weight (0.20 to 23.24%) and seed cotton yield (0.44 to 75.52%). However, 62% of F/sub 2/ populations revealed negative values for inbreeding depression, 14% for bolls per plant, 77% for boll weight and 21% for yield, revealed that these F/sub 2/ populations were more stable and performed better than F/sub 1/s even after segregation. Although, F/sub 2/ populations may display less heterosis as compared to F/sub 1/, but still better than high parents and can be used as

6 CFR 13.9 - Answer.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Answer. 13.9 Section 13.9 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.9 Answer. (a) The Defendant may request a hearing by serving an answer on the Reviewing Official within 30 days of service of...

6 CFR 13.34 - Evidence.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Evidence. 13.34 Section 13.34 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.34 Evidence. (a) The ALJ will determine the admissibility of evidence. (b) Except as provided in this part, the ALJ...

10 CFR 13.21 - Discovery.

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2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Discovery. 13.21 Section 13.21 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.21 Discovery. (a) The following types of discovery are...) Unless mutually agreed to by the parties, discovery is available only as ordered by the ALJ. The ALJ...

6 CFR 13.28 - Motions.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Motions. 13.28 Section 13.28 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.28 Motions. (a) Any application to the ALJ for an order or ruling will be by motion. Motions will state the relief...

6 CFR 13.33 - Witnesses.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Witnesses. 13.33 Section 13.33 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.33 Witnesses. (a) Except as provided in paragraph (b) of this section, testimony at the hearing will be given orally by...

Positron emitting nuclides and their synthetic incorporation in radiopharmaceuticals. [Labeled with /sup 11/C, /sup 13/N, and /sup 18/F

Energy Technology Data Exchange (ETDEWEB)

Fowler, J.S.

1976-01-01

/sup 11/C, /sup 13/N, and /sup 15/O has potential applicability to the study of metabolism in humans. Problems in the synthesis of radiopharmaceuticals labeled with /sup 11/C, /sup 13/N, and /sup 18/F are described: quality control, radiation exposure, carboxylic acids, glucose, amines, amino acids, nitrosources, fluoroethanol. 54 references. (DLC)

PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer {sup 18}F-AlF-NOTA-PRGD2

Energy Technology Data Exchange (ETDEWEB)

Gao, Haokao [The Fourth Military Medical University, Department of Cardiology, Xijing Hospital, Xi' an (China); National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Laboratory of Molecular Imaging and Nanomedicine (LOMIN), Bethesda, MD (United States); Lang, Lixin; Guo, Ning; Quan, Qimeng; Hu, Shuo; Kiesewetter, Dale O.; Niu, Gang; Chen, Xiaoyuan [National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Laboratory of Molecular Imaging and Nanomedicine (LOMIN), Bethesda, MD (United States); Cao, Feng [The Fourth Military Medical University, Department of Cardiology, Xijing Hospital, Xi' an (China)

2012-04-15

The {alpha}{sub v}{beta}{sub 3} integrin represents a potential target for noninvasive imaging of angiogenesis. The purpose of this study was to evaluate a novel one-step labeled integrin {alpha}{sub v}{beta}{sub 3}-targeting positron emission tomography (PET) probe, {sup 18}F-AlF-NOTA-PRGD2, for angiogenesis imaging in a myocardial infarction/reperfusion (MI/R) animal model. Male Sprague-Dawley rats underwent 45-min transient left coronary artery occlusion followed by reperfusion. The myocardial infarction was confirmed by ECG, {sup 18}F-fluorodeoxyglucose (FDG) imaging, and cardiac ultrasound. In vivo PET imaging was used to determine myocardial uptake of {sup 18}F-AlF-NOTA-PRGD2 at different time points following reperfusion. The control peptide RAD was labeled with a similar procedure and used to confirm the specificity. Ex vivo autoradiographic analysis and CD31/CD61 double immunofluorescence staining were performed to validate the PET results. Myocardial origin of the {sup 18}F-AlF-NOTA-PRGD2 accumulation was confirmed by {sup 18}F-FDG and autoradiography. PET imaging demonstrated increased focal accumulation of {sup 18}F-AlF-NOTA-PRGD2 in the infarcted area which started at day 3 (0.28 {+-} 0.03%ID/g, p < 0.05) and peaked between 1 and 3 weeks (0.59 {+-} 0.16 and 0.55 {+-} 0.13%ID/g, respectively). The focal accumulation decreased but still kept at a higher level than the sham group after 4 months of reperfusion (0.31 {+-} 0.01%ID/g, p < 0.05). Pretreatment with unlabeled arginine-glycine-aspartic acid (RGD) peptide significantly decreased tracer uptake, indicating integrin specificity of this tracer. At 1 week after MI/R, uptake of the control tracer {sup 18}F-AlF-NOTA-RAD that does not bind to integrin, in the infarcted area, was only 0.21 {+-} 0.01%ID/g. Autoradiographic imaging showed the same trend of uptake in the myocardial infarction area. The time course of focal tracer uptake was consistent with the pattern of vascular density and integrin {beta

6 CFR 13.25 - Fees.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Fees. 13.25 Section 13.25 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.25 Fees. The party requesting a subpoena will pay the cost of the fees and mileage of any witness subpoenaed in the amounts that...

14 CFR 13.79 - Hearing.

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2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Hearing. 13.79 Section 13.79 Aeronautics....79 Hearing. If an alleged violator requests a hearing in accordance with § 13.75, the procedure of Subpart D of this part applies. At the close of the hearing, the Hearing Officer, on the record or...

7 CFR 210.13 - Facilities management.

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2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false Facilities management. 210.13 Section 210.13... Participation § 210.13 Facilities management. Link to an amendment published at 74 FR 66216, Dec. 15, 2009. (a..., the added text is set forth as follows: § 210.13 Facilities management. (c) Food safety program. The...

13 CFR 107.501 - Identification as a Licensee.

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2010-01-01

... number. Before collecting an application fee or extending Financing to a Small Business, you must obtain... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Identification as a Licensee. 107.501 Section 107.501 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS...

Emission computed tomography of 18F-fluorodeoxyglucose and 13N-ammonia in stroke and epilepsy

International Nuclear Information System (INIS)

Kuhl, D.E.; Phelps, M.E.; Engel, J. Jr.

1980-01-01

The ECAT Positron Tomograph was used to scan normal control subjects, stroke patients at various times during recovery, and patients with partial epilepsy during EEG monitoring. 18 F-fluorodeoxyglucose ( 18 FDG) and 13 N-Ammonia ( 13 NH 3 ) were used as indicators of abnormalities in local cerebral glucose utilization (LCMR/sub glc/) and relative perfusion, respectively. Hypometabolism, due to deactivation or minimal damage, was demonstrated with the 18 FDG scan in deep structures and broad zones of cerebral cortex which appeared normal on x-ray CT (XCT) and /sup 99m/Tc pertechnetate scans. In patients with partial epilepsy, who had unilateral or focal electrical abnormalities, interictal 18 FDG scan patterns clearly showed localized regions of decreased (20 to 50%) LCMR/sub glc/, which correlated anatomically with the eventual EEG localization

26 CFR 1.665(f)-1A - Undistributed capital gain.

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2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Undistributed capital gain. 1.665(f)-1A Section... Beginning on Or After January 1, 1969 § 1.665(f)-1A Undistributed capital gain. (a) Domestic trusts. (1) The term undistributed capital gain means (in the case of a trust other than a foreign trust created by a U...

4 CFR 201.13 - Business information.

Science.gov (United States)

2010-01-01

... 4 Accounts 1 2010-01-01 2010-01-01 false Business information. 201.13 Section 201.13 Accounts RECOVERY ACCOUNTABILITY AND TRANSPARENCY BOARD PUBLIC INFORMATION AND REQUESTS § 201.13 Business information. (a) In general. Business information obtained by the Board from a submitter shall be disclosed...

Cyclotron resonant gas breakdown with a 1.22-nm 13CH3F laser

International Nuclear Information System (INIS)

Hacker, M.P.; Lax, B.; Metz, R.N.; Temkin, R.J.

1979-01-01

Cyclotron-resonant laser-induced gas breakdown has been studied for the first time in the transverse geometry, using 1.222-nm 13 CH 3 F laser radiation propagating perpendicular to the magnetic field axis. The line shape of absorbed laser radiation versus magnetic field near electron cyclotron resonance (87.75 kG) indicates a strong dependence of the line shape on the focused laser intensity. This dependence is not predicted by the standard equilibrium theory of high-frequency gas breakdown in a magnetic field. We have developed an analytic theory to explain the observed line shapes. The theory takes into account the laser propagation characteristics, in particular that there is nonuniform ionization due to strong resonant absorption of the laser radiation in a length comparable to or shorter than that of the laser focal volume. The transverse geometry simplifies the theoretical analysis because the observed line shapes are not significantly affected by Doppler broadening. Extensive data have been obtained on the fraction of laser pulse energy absorbed in the gas breakdown volume as a function of magnetic field, helium gas pressure, and incident laser pulse energy. Good quantitative agreement is obtained between the observed laser pulse absorption line shapes and the nonuniform ionization theory

13 CFR 142.4 - What is a statement?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What is a statement? 142.4 Section 142.4 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES ACT... representation, certification, affirmation, document, record, or accounting or bookkeeping entry made with...

7 CFR 1215.13 - Process.

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2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Process. 1215.13 Section 1215.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... CONSUMER INFORMATION Popcorn Promotion, Research, and Consumer Information Order Definitions § 1215.13...

The OsO(3)F(+) and mu-F(OsO(3)F)(2)(+) cations: their syntheses and study by Raman and (19)F NMR spectroscopy and electron structure calculations and X-ray crystal structures of [OsO(3)F][PnF(6)] (Pn = As, Sb), [OsO(3)F][HF](2)[AsF(6)], [OsO(3)F][HF][SbF(6)], and [OsO(3)F][Sb(3)F(16)].

Science.gov (United States)

Gerken, Michael; Dixon, David A; Schrobilgen, Gary J

2002-01-28

The fluoride ion donor properties of OsO(3)F(2) have been investigated. The salts [OsO(3)F][AsF(6)], [OsO(3)F][HF](2)[AsF(6)], mu-F(OsO(3)F)(2)[AsF(6)], [OsO(3)F][HF](2)[SbF(6)], and [OsO(3)F][HF][SbF(6)] have been prepared by reaction of OsO(3)F(2) with AsF(5) and SbF(5) in HF solvent and have been characterized in the solid state by Raman spectroscopy. The single-crystal X-ray diffraction studies of [OsO(3)F][AsF(6)] (P2(1)/n, a = 7.0001(11) A, c = 8.8629(13) A, beta = 92.270(7) degrees, Z = 4, and R(1) = 0.0401 at -126 degrees C), [OsO(3)F][SbF(6)] (P2(1)/c, a = 5.4772(14) A, b = 10.115(3) A, c = 12.234(3) A, beta = 99.321(5) degrees, Z = 4, and R(1) = 0.0325 at -173 degrees C), [OsO(3)F][HF](2)[AsF(6)] (P2(1)/n, a = 5.1491(9) A, b = 8.129(2) A, c = 19.636(7) A, beta = 95.099(7) degrees, Z = 4, and R(1) = 0.0348 at -117 degrees C), and [OsO(3)F][HF][SbF(6)] (Pc, a = 5.244(4) A, b = 9.646(6) A, c = 15.269(10) A, beta = 97.154(13) degrees, Z = 4, and R(1) = 0.0558 at -133 degrees C) have shown that the OsO(3)F(+) cations exhibit strong contacts to the anions and HF solvent molecules giving rise to cyclic, dimeric structures in which the osmium atoms have coordination numbers of 6. The reaction of OsO(3)F(2) with neat SbF(5) yielded [OsO(3)F][Sb(3)F(16)], which has been characterized by (19)F NMR spectroscopy in SbF(5) and SO(2)ClF solvents and by Raman spectroscopy and single-crystal X-ray diffraction in the solid state (P4(1)m, a = 10.076(6) A, c = 7.585(8) A, Z = 2, and R(1) = 0.0858 at -113 degrees C). The weak fluoride ion basicity of the Sb(3)F(16)(-) anion resulted in an OsO(3)F(+) cation (C(3)(v) point symmetry) that is well isolated from the anion and in which the osmium is four-coordinate. The geometrical parameters and vibrational frequencies of OsO(3)F(+), ReO(3)F, mu-F(OsO(3)F)(2)(+), (FO(3)Os--FPnF(5))(2), and (FO(3)Os--(HF)(2)--FPnF(5))(2) (Pn = As, Sb) have been calculated using density functional theory methods.

7 CFR 1437.13 - Multiple benefits.

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2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Multiple benefits. 1437.13 Section 1437.13... General Provisions § 1437.13 Multiple benefits. (a) If a producer is eligible to receive payments under this part and benefits under any other program administered by the Secretary for the same crop loss...

6 CFR 13.24 - Protective order.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Protective order. 13.24 Section 13.24 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.24 Protective order. (a) A party or a prospective witness or deponent may file a motion for a protective order...

6 CFR 13.19 - Prehearing conferences.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Prehearing conferences. 13.19 Section 13.19 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.19 Prehearing conferences. (a) The ALJ may schedule prehearing conferences as appropriate. (b...

13 CFR 142.3 - What is a claim?

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2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What is a claim? 142.3 Section 142.3 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES ACT REGULATIONS Overview and Definitions § 142.3 What is a claim? (a) Claim means any request, demand, or...

7 CFR 925.13 - Container.

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2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Container. 925.13 Section 925.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... SOUTHEASTERN CALIFORNIA Definitions § 925.13 Container. Container means any lug, box, bag, crate, carton, or...

7 CFR 29.1043 - Orange (F).

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2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Orange (F). 29.1043 Section 29.1043 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 92) § 29.1043 Orange (F). A reddish yellow. [42 FR 21092, Apr. 25, 1977. Redesignated at 47 FR...

13C separation by IRMPD of halogenated difluoromethanes

International Nuclear Information System (INIS)

Ma Peihua; Chen Guancheng; Wu Bin; Liu Julin; Jing Yan; Chu Minxiong; Arai, Shigeyoshi.

1995-01-01

Isotopically-selective consecutive two-stage infrared multiphoton dissociation (IRMPD) of halogenated difluoromethanes in the presence of scavengers produces carbon-13 over 95 %. The reaction mechanism for the IRMPD of mixture of CHClF 2 and HI can be explained by a series of first-order dissociation reactions and followed radical-scavenger reactions occurred in a continuous irradiation procedure. Furthermore, 13 C enrichment at laboratory scaling-up level by the 13 C selective IRMPD of CHClF 2 /Br 2 mixture has been investigated in a flow reactor. The 13 C production rates, 13 C atomic fractions in the CBr 2 F 2 products and 13 C depletions in the CHClF 2 reactants at different flow rates and laser repetition frequencies were examined to optimize the parameters suitable for large-scale production of carbon isotope. The data obtained from the flow tests demonstrated a 40 mg h -1 production rate for CB 2 F 2 at 65 % carbon-13 by using a 40 W (4J, 10 Hz) laser beam focused with a lens of focal length 120 cm. If a reliable TEA CO 2 laser can be operated with 100 W (10 J, 10 Hz) output, the production rate of CBr 2 F 2 for carbon-13 at 60 % can attain 200 mg h -1 . The measurements of spatial profile of focused laser beam imply a 2 g h -1 production rate for the 60 % carbon-13 product for an incident power of 200 W (20 J, 10 Hz). (author)

6 CFR 13.35 - The record.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false The record. 13.35 Section 13.35 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.35 The record. (a) The hearing will be recorded and transcribed. Transcripts may be obtained following the...

7 CFR 929.13 - Sales history.

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2010-01-01

... 7 Agriculture 8 2010-01-01 2010-01-01 false Sales history. 929.13 Section 929.13 Agriculture... LONG ISLAND IN THE STATE OF NEW YORK Order Regulating Handling Definitions § 929.13 Sales history. Sales history means the number of barrels of cranberries established for a grower by the committee...

7 CFR 771.13 - Loan closing.

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2010-01-01

... 7 Agriculture 7 2010-01-01 2010-01-01 false Loan closing. 771.13 Section 771.13 Agriculture... SPECIAL PROGRAMS BOLL WEEVIL ERADICATION LOAN PROGRAM § 771.13 Loan closing. (a) Conditions. The applicant must meet all conditions specified by the loan approval official in the notification of loan approval...

E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription

DEFF Research Database (Denmark)

Cartwright, P; Müller, H; Wagener, C

1998-01-01

with E2Fs 1-5, especially within the DNA binding, heterodimerization and marked box domains. Unlike E2Fs 1-5, E2F-6 lacks a transactivation and a pocket protein binding domain, hence, forms a unique third group within the E2F family. E2F-6 is a nuclear protein that can form heterodimers with the DP......The E2F family of transcription factors are essential for the regulation of genes required for appropriate progression through the cell cycle. Five members of the E2F family have been previously reported, namely E2F1-5. All five are key elements in transcriptional regulation of essential genes......, and they can be divided into two functional groups, those that induce S-phase progression when overexpressed in quiescent cells (E2Fs 1-3), and those that do not (E2Fs 4-5). Here, we describe the identification of a novel member of this family, which we refer to as E2F-6. E2F-6 shares significant homology...

6 CFR 13.37 - Initial Decision.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Initial Decision. 13.37 Section 13.37 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.37 Initial Decision. (a) The ALJ will issue an Initial Decision based only on the record, which will contain...

10 CFR 605.13 - Cost sharing.

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2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Cost sharing. 605.13 Section 605.13 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS THE OFFICE OF ENERGY RESEARCH FINANCIAL ASSISTANCE PROGRAM § 605.13 Cost sharing. Cost sharing is not required nor will it be considered as a criterion in the...

Sp1/3 and NF-1 mediate basal transcription of the human P2X1 gene in megakaryoblastic MEG-01 cells

Directory of Open Access Journals (Sweden)

Ennion Steven J

2006-03-01

Full Text Available Abstract Background P2X1 receptors play an important role in platelet function as they can induce shape change, granule centralization and are also involved in thrombus formation. As platelets have no nuclei, the level of P2X1 expression depends on transcriptional regulation in megakaryocytes, the platelet precursor cell. Since nothing is known about the molecular mechanisms regulating megakaryocytic P2X1 expression, this study aimed to identify and functionally characterize the P2X1 core promoter utilized in the human megakaryoblastic cell line MEG-01. Results In order to identify cis-acting elements involved in the transcriptional regulation of P2X1 expression, the ability of 4.7 kb P2X1 upstream sequence to drive luciferase reporter gene expression was tested. Low promoter activity was detected in proliferating MEG-01 cells. This activity increased 20-fold after phorbol-12-myristate-13-acetate (PMA induced differentiation. A transcription start site was detected 365 bp upstream of the start codon by primer extension. Deletion analysis of reporter constructs indicated a core promoter located within the region -68 to +149 bp that contained two Sp1 sites (named Sp1a and Sp1b and an NF-1 site. Individual mutations of Sp1b or NF-1 binding sites severely reduced promoter activity whereas triple mutation of Sp1a, Sp1b and NF-1 sites completely abolished promoter activity in both untreated and PMA treated cells. Sp1/3 and NF-1 proteins were shown to bind their respective sites by EMSA and interaction of Sp1/3, NF-1 and TFIIB with the endogenous P2X1 core promoter in MEG-01 cells was demonstrated by chromatin immunoprecipitation. Alignment of P2X1 genes from human, chimp, rat, mouse and dog revealed consensus Sp1a, Sp1b and NF-1 binding sites in equivalent positions thereby demonstrating evolutionary conservation of these functionally important sites. Conclusion This study has identified and characterized the P2X1 promoter utilized in MEG-01 cells and

12 CFR 583.13 - Office.

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2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Office. 583.13 Section 583.13 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEFINITIONS FOR REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.13 Office. The term Office means the Office of Thrift Supervision. ...

6 CFR 13.2 - Definitions.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Definitions. 13.2 Section 13.2 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.2 Definitions. The...) Authority means the Department of Homeland Security. (c) Authority Head means the Deputy Secretary...

The nucleotide sequence of satellite RNA in grapevine fanleaf virus, strain F13.

Science.gov (United States)

Fuchs, M; Pinck, M; Serghini, M A; Ravelonandro, M; Walter, B; Pinck, L

1989-04-01

The nucleotide sequence of cDNA copies of grapevine fanleaf virus (strain F13) satellite RNA has been determined. The primary structure obtained was 1114 nucleotides in length, excluding the poly(A) tail, and contained only one long open reading frame encoding a 341 residue, highly hydrophilic polypeptide of Mr37275. The coding sequence was bordered by a leader of 14 nucleotides and a 3'-terminal non-coding region of 74 nucleotides. No homology has been found with small satellite RNAs associated with other nepoviruses. Two limited homologies of eight nucleotides have been detected between the satellite RNA in grapevine fanleaf virus and those in tomato black ring virus, and a consensus sequence U.G/UGAAAAU/AU/AU/A at the 5' end of nepovirus RNAs is reported. A less extended consensus exists in this region in comovirus and picornavirus RNA.

12 CFR 404.13 - Definitions.

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2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Definitions. 404.13 Section 404.13 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES INFORMATION DISCLOSURE Access to Records Under the Privacy Act of 1974 § 404.13 Definitions. For purposes of this subpart, the following definitions shall apply...

14 CFR 171.13 - Reports.

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2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Reports. 171.13 Section 171.13 Aeronautics... FACILITIES NON-FEDERAL NAVIGATION FACILITIES VOR Facilities § 171.13 Reports. The owner of each facility to which this subpart applies shall make the following reports on forms furnished by the FAA, at the times...

15 CFR 10.13 - Withdrawal of a published standard.

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2010-01-01

...) Before withdrawing a standard published under these procedures, the Director will review the relative... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Withdrawal of a published standard. 10... DEVELOPMENT OF VOLUNTARY PRODUCT STANDARDS § 10.13 Withdrawal of a published standard. (a) Standards published...

7 CFR 246.13 - Financial management system.

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2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false Financial management system. 246.13 Section 246.13... State Agency Provisions § 246.13 Financial management system. (a) Disclosure of expenditures. The State agency shall maintain a financial management system which provides accurate, current and complete...

13 CFR 107.520 - Management Expenses of a Licensee.

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2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Management Expenses of a Licensee. 107.520 Section 107.520 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION SMALL BUSINESS INVESTMENT COMPANIES Managing the Operations of a Licensee Management and Compensation § 107.520 Management...

Synthesis of n.c.a. {sup 18}F-fluorinated NMDA- and D{sub 4}-receptor ligands via [{sup 18}F]fluorobenzenes; Traegerarme Synthese {sup 18}F-markierter, ausgewaehlter NMDA- und D{sub 4}-Rezeptorliganden durch Einsatz geeigneter [{sup 18}F]Fluorbenzolderivate

Energy Technology Data Exchange (ETDEWEB)

Ludwig, T

2005-11-01

In this thesis new strategies were developed and evaluated for the no-carrier-added (n.c.a.) {sup 18}F-labelling of receptor ligands as radiodiagnostics for characterization of brain receptors using positron-emission-tomography (PET). Special emphasis was placed on the synthesis of n.c.a. ({+-})-3-(4-hydroxy-4-(4-[{sup 18}F]fluorophenyl)-piperidin-l-yl)chroman-4,7-diol, a ligand with high affinity for the NR2B subtype of NMDA receptors and n.c.a. (3-(4-[{sup 18}F]fluorphenoxy)propyl)-(2-(4-tolylphenoxy)ethyl)amine ([{sup 18}F]FPTEA) a dopamine D{sub 4} receptor ligand. In order to synthesize n.c.a. ({+-})-3-(4-hydroxy-4-(4-[{sup 18}F]fluorophenyl)-piperidin-l-yl)chroman-4,7-diol the {sup 18}F-fluoroarylation method via metallorganic intermediates was modified and improved. The suitability of the organometallic {sup 18}F-fluoroarylation agents was proven with several model compounds. High radiochemical yields of 20-30% were obtained also with piperidinone-derivatives. The preparation of a suitable precursor for the synthesis of the NMDA receptor ligand, however, could not be achieved by synthesis of appropriate 1,3-dioxolane protected piperidinone derivatives. Further, the synthesis of n.c.a. ([{sup 18}F]fluoroaryloxy)alkylamines via n.c.a. 4-[{sup 18}F]fluorophenol was developed and evaluated. The synthesis of n.c.a. [{sup 18}F]fluoroarylethers with corresponding model compounds was optimized and led to a radiochemical yield of 25-60%, depending on the alkylhalide used. The preparation of n.c.a. 1-(3-bromopropoxy)-4-[{sup 18}F]fluorobenzene proved advantageous in comparison to direct use of 4-[{sup 18}]fluorophenol for coupling with a corresponding N-protected precursor for the synthesis of n.c.a. [{sup 18}F]FPTEA. With regard to the radiochemical yields and the loss of activity during the synthesis and isolation of n.c.a. 4-[{sup 18}F]fluorophenol and n.c.a. 1-(3-bromopropoxy)-4-[{sup 18}F]fluorobenzene, [{sup 18}F]FPTEA was obtained by reaction with 2-(4-tolyloxy

12 CFR 563f.6 - General exemption.

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2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false General exemption. 563f.6 Section 563f.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS... controlled or managed by persons who are members of a minority group, or women; (3) Is a depository...

26 CFR 1.669(f)-1A - Character of capital gain.

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2010-04-01

... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Character of capital gain. 1.669(f)-1A Section 1... Before January 1, 1969 § 1.669(f)-1A Character of capital gain. Amounts distributed as a capital gain... the gain had with respect to the trust. Thus, a capital gain that was taxed to the trust as a “long...

6 CFR 13.41 - Stay pending appeal.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Stay pending appeal. 13.41 Section 13.41 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.41 Stay pending appeal. (a) An Initial Decision is stayed automatically pending disposition of a...

14 CFR 13.17 - Seizure of aircraft.

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2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Seizure of aircraft. 13.17 Section 13.17... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Legal Enforcement Actions § 13.17 Seizure of aircraft. (a) Under... officer, or a Federal Aviation Administration safety inspector, authorized in an order of seizure issued...

Reconstructing recent human phylogenies with forensic STR loci: A statistical approach

Directory of Open Access Journals (Sweden)

Khan Faisal

2005-09-01

Full Text Available Abstract Background Forensic Short Tandem Repeat (STR loci are effective for the purpose of individual identification, and other forensic applications. Most of these markers have high allelic variability and mutation rate because of which they have limited use in the phylogenetic reconstruction. In the present study, we have carried out a meta-analysis to explore the possibility of using only five STR loci (TPOX, FES, vWA, F13A and Tho1 to carry out phylogenetic assessment based on the allele frequency profile of 20 world population and north Indian Hindus analyzed in the present study. Results Phylogenetic analysis based on two different approaches – genetic distance and maximum likelihood along with statistical bootstrapping procedure involving 1000 replicates was carried out. The ensuing tree topologies and PC plots were further compared with those obtained in earlier phylogenetic investigations. The compiled database of 21 populations got segregated and finely resolved into three basal clusters with very high bootstrap values corresponding to three geo-ethnic groups of African, Orientals, and Caucasians. Conclusion Based on this study we conclude that if appropriate and logistic statistical approaches are followed then even lesser number of forensic STR loci are powerful enough to reconstruct the recent human phylogenies despite of their relatively high mutation rates.

49 CFR 200.13 - Publication.

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2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Publication. 200.13 Section 200.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION INFORMAL RULES OF PRACTICE FOR PASSENGER SERVICE § 200.13 Publication. (a) General notice of any...

13 CFR 120.830 - Reports a CDC must submit.

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2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Reports a CDC must submit. 120.830 Section 120.830 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development... each new associate and staff, a Statement of Personal History (for use by non-bank lenders and CDCs...

Performance evaluation of the micro PET focus 120 with the 11C, 13N, and 18F radionuclides

International Nuclear Information System (INIS)

Trejo B, F.; Ortega L, N.; Ojeda F, R.; Avila R, M. A.

2010-01-01

The aim of this work is to evaluate the characteristics involved in the data acquisition and image reconstruction of a micro PET Focus 120 system. Energy resolution, spatial resolution, sensitivity, count rate and image quality characteristics were evaluated using different phantoms with three conventional positron emitter radionuclides used in PET imaging ( 11 C, 13 N and 18 F). Some tests performed in this work are from the new protocol Nema NU4 - 2008. (Author)

7 CFR 2902.13 - Diesel fuel additives.

Science.gov (United States)

2010-01-01

... Items § 2902.13 Diesel fuel additives. (a) Definition. (1) Any substance, other than one composed solely of carbon and/or hydrogen, that is intentionally added to diesel fuel (including any added to a motor... 7 Agriculture 15 2010-01-01 2010-01-01 false Diesel fuel additives. 2902.13 Section 2902.13...

10 CFR 13.41 - Stay pending appeal.

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2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Stay pending appeal. 13.41 Section 13.41 Energy NUCLEAR REGULATORY COMMISSION PROGRAM FRAUD CIVIL REMEDIES § 13.41 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration or of an appeal to the authority...

14 CFR 413.13 - Complete application.

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2010-01-01

... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Complete application. 413.13 Section 413.13 Aeronautics and Space COMMERCIAL SPACE TRANSPORTATION, FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION LICENSING LICENSE APPLICATION PROCEDURES § 413.13 Complete application. The FAA's acceptance of an...

6 CFR 13.14 - Separation of functions.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Separation of functions. 13.14 Section 13.14 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.14 Separation of functions. (a) The Investigating Official, the Reviewing Official, and any...

Benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives as multiple inhibitors of bacterial Mur ligases (MurC-MurF).

Science.gov (United States)

Perdih, Andrej; Hrast, Martina; Barreteau, Hélène; Gobec, Stanislav; Wolber, Gerhard; Solmajer, Tom

2014-08-01

Enzymes catalyzing the biosynthesis of bacterial peptidoglycan represent traditionally a collection of highly selective targets for novel antibacterial drug design. Four members of the bacterial Mur ligase family-MurC, MurD, MurE and MurF-are involved in the intracellular steps of peptidoglycan biosynthesis, catalyzing the synthesis of the peptide moiety of the Park's nucleotide. In our previous virtual screening campaign, a chemical class of benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole derivatives exhibiting dual MurD/MurE inhibition properties was discovered. In the present study we further investigated this class of compounds by performing inhibition assays on all four Mur ligases (MurC-MurF). Furthermore, molecular dynamics (MD) simulation studies of one of the initially discovered compound 1 were performed to explore its geometry as well as its energetic behavior based on the Linear Interaction Energy (LIE) method. Further in silico virtual screening (VS) experiments based on the parent active compound 1 were conducted to optimize the discovered series. Selected hits were assayed against all Escherichia coli MurC-MurF enzymes in biochemical inhibition assays and molecules 10-14 containing benzene-1,3-dicarboxylic acid 2,5-dimethylpyrrole coupled with five member-ring rhodanine moiety were found to be multiple inhibitors of the whole MurC-MurF cascade of bacterial enzymes in the micromolar range. Steady-state kinetics studies suggested this class to act as competitive inhibitors of the MurD enzyme towards d-Glu. These compounds represent novel valuable starting point in the development of novel antibacterial agents. Copyright © 2014 Elsevier Ltd. All rights reserved.

6 CFR 13.12 - Notice of hearing.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Notice of hearing. 13.12 Section 13.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.12 Notice of hearing. (a) When the ALJ receives the Complaint and answer, the ALJ will promptly serve a...

6 CFR 13.8 - Service of Complaint.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Service of Complaint. 13.8 Section 13.8 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.8 Service of Complaint. (a) Service of a Complaint must be Made by certified or registered mail or by...

7 CFR 29.13 - The act.

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2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false The act. 29.13 Section 29.13 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... INSPECTION Regulations Definitions § 29.13 The act. The Tobacco Inspection Act, approved August 23, 1935. (7...

30 CFR 822.13 - Monitoring.

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2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Monitoring. 822.13 Section 822.13 Mineral... § 822.13 Monitoring. (a) A monitoring system shall be installed, maintained, and operated by the... until all bonds are released in accordance with Subchapter J of this chapter. The monitoring system...

6 CFR 13.20 - Disclosure of Documents.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Disclosure of Documents. 13.20 Section 13.20 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.20 Disclosure of Documents. (a) Upon written request to the Reviewing Official, the Defendant may...

6 CFR 13.46 - Compromise or settlement.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Compromise or settlement. 13.46 Section 13.46 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.46 Compromise or settlement. (a) Parties may Make offers of compromise or settlement at any time...

10 CFR 503.13 - Environmental impact analysis.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Environmental impact analysis. 503.13 Section 503.13... Exemptions § 503.13 Environmental impact analysis. In order to enable OFE to comply with NEPA, a petitioner..., and land resources; (3) Direct and indirect environmental impacts of the proposed action including...

Dicty_cDB: FC-AI13 [Dicty_cDB

Lifescience Database Archive (English)

Full Text Available FC (Link to library) FC-AI13 (Link to dictyBase) - - - Contig-U16263-1 FC-AI13F (Li...nk to Original site) FC-AI13F 507 - - - - - - Show FC-AI13 Library FC (Link to library) Clone ID FC-AI13 (Li.../dictycdb.biol.tsukuba.ac.jp/CSM/FC/FC-AI/FC-AI13Q.Seq.d/ Representative seq. ID FC-AI...13F (Link to Original site) Representative DNA sequence >FC-AI13 (FC-AI13Q) /CSM/FC/FC-AI/FC-AI13Q.Seq....nificant alignments: (bits) Value FC-AI13 (FC-AI13Q) /CSM/FC/FC-AI/FC-AI13Q.Seq.d/ 963 0.0 VSA730 (VSA730Q)

New organic superconductors beta-(BDA-TTP)2X [BDA-TTP + 2,5-bis(1,3-dithian-2ylidene)-1,3,4,6-tetrathiapentalene; X(-) = SbF6(-), AsF6(-), and PF6(-)].

Science.gov (United States)

Yamada, J; Watanabe, M; Akutsu, H; Nakatsuji, S; Nishikawa, H; Ikemoto, I; Kikuchi, K

2001-05-09

The synthesis, electrochemical properties, and molecular structure of a new pi-electron donor, 2,5-bis(1,3-dithian-2-ylidene)-1,3,4,6-tetrathiapentalene (BDA-TTP), is described. In contrast to the hitherto-known tetrachalcogenafulvalene pi-donors providing organic superconductors, this donor contains only the bis-fused 1,3-dithiole-2-ylidene unit as a pi-electron system, yet produces a series of ambient-pressure superconductors beta-(BDA-TTP)2X [X = SbF6 (magnetic T(c) = 6.9 K, resistive T(c) = 7.5 K), AsF6 (magnetic T(c) = 5.9 K, resistive T(c) = 5.8 K), and PF6 (magnetic T(c) = 5.9 K)], which are isostructural. The values of the intermolecular overlap integrals calculated on the donor layers of these superconductors suggest a two-dimensional (2D) electronic structure with loose donor packing. Tight-binding band calculations also indicate that these superconductors have the 2D band dispersion relations and closed Fermi surfaces.

17 CFR 240.13a-20 - Plain English presentation of specified information.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Plain English presentation of specified information. 240.13a-20 Section 240.13a-20 Commodity and Securities Exchanges SECURITIES AND... Regulations Under the Securities Exchange Act of 1934 Other Reports § 240.13a-20 Plain English presentation of...

14 CFR 13.225 - Offer of proof.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Offer of proof. 13.225 Section 13.225... INVESTIGATIVE AND ENFORCEMENT PROCEDURES Rules of Practice in FAA Civil Penalty Actions § 13.225 Offer of proof. A party whose evidence has been excluded by a ruling of the administrative law judge may offer the...

12 CFR 412.13 - Limitations and penalties.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Limitations and penalties. 412.13 Section 412.13 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES ACCEPTANCE OF PAYMENT FROM A NON-FEDERAL SOURCE FOR TRAVEL EXPENSES § 412.13 Limitations and penalties. (a) This part is in addition to and not in...

New nonlinear-laser properties of ferroelectric Nd3+:Ba2NaNb5O15 - cw stimulated emission (4F3/2 → 4I11/2 and 4F3/2 → 4I13/2 ), collinear and diffuse self-frequency doubling and summation

International Nuclear Information System (INIS)

Kaminskii, Alexandr A; Jaque, D; Garsia, Sole J; Capmany, J; Bagayev, S N; Ueda, Ken-ichi

1999-01-01

A new cw laser with self-frequency doubling and summation of 1-μm oscillation ( 4 F 3/2 → 4 I 11/2 ) was constructed on the basis of an orthorhombic Nd 3+ :Ba 2 NaNb 5 O 15 crystal. The 4 F 3/2 → 4 I 13/2 inter-Stark transition was used to excite cw 1.3-μm stimulated emission from this ferroelectric. (letters to the editor)

22 CFR 1507.13 - Reports.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Reports. 1507.13 Section 1507.13 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION RULES SAFEGUARDING PERSONAL INFORMATION § 1507.13 Reports. (a) The... to establish or alter any system or records as defined herein. This report will be submitted in...

32 CFR Appendix F to Part 505 - Example of a System of Records Notice

Science.gov (United States)

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Example of a System of Records Notice F Appendix... AUTHORITIES AND PUBLIC RELATIONS ARMY PRIVACY ACT PROGRAM Pt. 505, App. F Appendix F to Part 505—Example of a... number, for example, A0025-55, where “A” indicates “Army,” the next number represents the publication...

6 CFR 13.17 - Rights of parties.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Rights of parties. 13.17 Section 13.17 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.17 Rights of parties. Except as otherwise limited by this part, all parties may: (a) Be accompanied...

6 CFR 13.32 - Location of hearing.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Location of hearing. 13.32 Section 13.32 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.32 Location of hearing. (a) The hearing may be held: (1) In any judicial district of the United...

36 CFR 13.976 - Fire.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Fire. 13.976 Section 13.976 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR NATIONAL PARK... (fda) § 13.976 Fire. Lighting or maintaining a fire is prohibited in the FDA except— (a) In established...

Antiferromagnetic CsCrF{sub 5} and canted antiferromagnetism in RbCrF{sub 5} and KCrF{sub 5}

Energy Technology Data Exchange (ETDEWEB)

Jagličić, Zvonko, E-mail: zvonko.jaglicic@imfm.si [University of Ljubljana, Faculty of Civil and Geodetic Engineering, and Institute of Mathematics, Physics and Mechanics, Jadranska 19, 1000 Ljubljana (Slovenia); Mazej, Zoran, E-mail: zoran.mazej@ijs.si [Department of Inorganic Chemistry and Technology, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana (Slovenia)

2017-07-15

Highlights: • Cr(IV) ions are antiferromagnetically coupled within chains in ACrF{sub 5} (A = Cs, Rb, K). • Small structural difference causes huge difference in magnetic properties below 10 K. • Canted antiferromagnetism has been observed in RbCrF{sub 5} and KCrF{sub 5} at low temperature. - Abstract: In ACrF{sub 5} (A = Cs, Rb, K), Cr(IV) ions are coordinated by six fluoride ligands where the resulting CrF{sub 6} octahedra share cis vertexes to form infinite chains of ([Cr{sup IV}F{sub 5}]{sup −}){sub n}. The geometry of the latter in Cs compound differs from that in K and Rb compounds. The results of investigations of the magnetic behaviour of these compounds have shown that an antiferromagnetic superexchange interaction is present within the chains with J{sub Cs} = −10.2 cm{sup −1}, J{sub Rb} = −13.3 cm{sup −1}, and J{sub K} = −13.1 cm{sup −1}. Additional ferromagnetic-like long-range ordering has been observed in KCrF{sub 5} and RbCrF{sub 5} below 6 K which can be explained, in a correlation with their crystal structures, as canted antiferromagnetism.

18 CFR 16.13 - Standards and factors for issuing a new license.

Science.gov (United States)

2010-04-01

... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Standards and factors for issuing a new license. 16.13 Section 16.13 Conservation of Power and Water Resources FEDERAL... and 15 of the Federal Power Act § 16.13 Standards and factors for issuing a new license. (a) In...

6 CFR 13.42 - Judicial review.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Judicial review. 13.42 Section 13.42 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.42 Judicial review. Section 3805 of title 31, United States Code, authorizes judicial review by an appropriate...

7 CFR 249.13 - Program income.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false Program income. 249.13 Section 249.13 Agriculture....13 Program income. Program income means gross income the State agency earns from grant supported... property. The State agency must retain Program income earned during the agreement period and use it for...

10 CFR 1040.13 - Discrimination prohibited.

Science.gov (United States)

2010-01-01

... 10 Energy 4 2010-01-01 2010-01-01 false Discrimination prohibited. 1040.13 Section 1040.13 Energy..., as Amended; and Section 401 of the Energy Reorganization Act of 1974 § 1040.13 Discrimination... benefits of, or be otherwise subjected to discrimination under any program to which this subpart applies...

NCBI nr-aa BLAST: CBRC-DNOV-01-2127 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-DNOV-01-2127 ref|YP_712620.1| [NiFe] hydrogenase maturation protein HypF [Fran...kia alni ACN14a] emb|CAJ61046.1| [NiFe] hydrogenase maturation protein HypF [Frankia alni ACN14a] YP_712620.1 0.81 32% ...

NCBI nr-aa BLAST: CBRC-ETEL-01-0698 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-ETEL-01-0698 ref|YP_441274.1| HesA/MoeB/ThiF family protein [Burkholderia thailand...ensis E264] gb|ABC38646.1| HesA/MoeB/ThiF family protein [Burkholderia thailandensis E264] YP_441274.1 0.73 41% ...

6 CFR 13.27 - Computation of time.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Computation of time. 13.27 Section 13.27 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.27 Computation of time. (a) In computing any period of time under this part or in an order issued...

12 CFR 13.4 - Recommendations to customers.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Recommendations to customers. 13.4 Section 13.4... PRACTICES § 13.4 Recommendations to customers. In recommending to a customer the purchase, sale or exchange... reasonable grounds for believing that the recommendation is suitable for the customer upon the basis of the...

7 CFR 35.13 - Minimum quantity.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Minimum quantity. 35.13 Section 35.13 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... part, transport or receive for transportation to any foreign destination, a shipment of 25 packages or...

Estimation of exposure quantity of gamma and neutron in 13 MeV proton cyclotron for radioisotope production of 18F

International Nuclear Information System (INIS)

Sunardi; Silakhuddin

2015-01-01

Quantitative estimation of gamma and neutron exposure in 13 MeV proton cyclotron for radioisotope of 18 F has been done. The aim of this study is to know the exposure of gamma and neutron that will be generated by 13 MeV proton cyclotron The method that was used is the determine of gamma and neutron quantity exposure that produced by proton beam collision with matter in the cyclotron chamber and cyclotron target. The analysis result showed that the reactions occur at chamber are 63 Cu(p,n) 63 Zn, 65 Cu(p,n) 65 Zn and 56 Fe(p,n) 56 Co,, while at the target is 18 O(p,n) 18 F. The calculation result of neutron flux at the chamber and the target facility are 7,34×10 7 n/cm 2 dt and 1.10×10 9 n/cm 2 dt, respectively. The gamma activity at the chamber for reaction 63 Cu(p,n) 63 Zn, 65 Cu(p,n) 65 Zn and 56 Fe(p,n) 56 Co are 3,0×10 8 Bq, 4,54×10 5 Bq and 1,13×10 9 Bq respectively, while the gamma activity at the cyclotron target is 1,84×10 8 Bq. The data can be used as a basis for designing the cyclotron radiation shielding. (author)

36 CFR 2.13 - Fires.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Fires. 2.13 Section 2.13... PROTECTION, PUBLIC USE AND RECREATION § 2.13 Fires. (a) The following are prohibited: (1) Lighting or maintaining a fire, except in designated areas or receptacles and under conditions that may be established by...

Nonlinear susceptibility: A direct test of the quadrupolar Kondo effect in UBe13

International Nuclear Information System (INIS)

Ramirez, A.P.; Chandra, P.; Coleman, P.; Fisk, Z.; Smith, J.L.; Ott, H.R.

1994-01-01

We present the nonlinear susceptibility as a direct test of the quadrupolar Kondo scenario for heavy fermion behavior, and apply it to the case of cubic crystal-field symmetry. Within a single-ion model we compute the nonlinear susceptibility resulting from low-lying Γ 3 (5f 2 ) and Kramers (5f 3 ) doublets. We find that nonlinear susceptibility measurements on single-crystal UBe 13 are inconsistent with a quadrupolar (5f 2 ) ground state of the uranium ion; the experimental data indicate that the low-lying magnetic excitations of UBe 13 are predominantly dipolar in character

12 CFR Appendices F-I to Part 41 - [Reserved

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false [Reserved] F Appendices F-I to Part 41 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR CREDIT REPORTING Appendices F-I to Part 41[Reserved] ...

45 CFR 13.24 - Settlements.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Settlements. 13.24 Section 13.24 Public Welfare... ACT IN AGENCY PROCEEDINGS Procedures for Considering Applications § 13.24 Settlements. The applicant and the agency's litigating party may agree on a proposed settlement of the award at any time prior to...

44 CFR 13.33 - Supplies.

Science.gov (United States)

2010-10-01

... aggregate fair market value upon termination or completion of the award, and if the supplies are not needed... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Supplies. 13.33 Section 13.33... GOVERNMENTS Post-Award Requirements Changes, Property, and Subawards § 13.33 Supplies. (a) Title. Title to...

15 CFR 303.13 - Appeals.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Appeals. 303.13 Section 303.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL... and two copies with the U.S. Department of Commerce, Import Administration, International Trade...

Labeling of complex molecules with 18F, 13N, and 11C. Progress report, March 1, 1981-February 28, 1982

International Nuclear Information System (INIS)

Brownell, G.L.; Elmaleh, D.R.

1981-09-01

The overall objective during the period covered by this report was to develop a broad spectrum of radiopharmaceuticals labeled with short-lived cyclotron produced positron emitters, 11 C, 13 N and 18 F. The progress report of this year will summarize work done in the last three years. The goals of the program during the last three years were: to build and complete the transport system to Nuclear Medicine; to complete the modular automated system for important precursor production: formaldehyde, methyliodide, cyanide; to perform animal studies with the 18 F-glucose analogs 2FDG and 3FDG and measure the rate constants and glucose metabolic rates derived from the Sokoloff model for both agents in different animal species; to initiate the development of new fatty acid analogs for myocardial imaging and metabolism; and to develop syntheses for 18 F and 11 C sugar analogs

45 CFR 1602.13 - Fees.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Fees. 1602.13 Section 1602.13 Public Welfare... INFORMATION UNDER THE FREEDOM OF INFORMATION ACT § 1602.13 Fees. (a) No fees will be charged for information routinely provided in the normal course of doing business. (b)(1) Fees shall be limited to reasonable...

45 CFR 1630.13 - Time.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Time. 1630.13 Section 1630.13 Public Welfare... § 1630.13 Time. (a) Computation. Time limits specified in this part shall be computed in accordance with... recipient's written request for good cause, grant an extension of time and shall so notify the recipient in...

12 CFR 13.3 - Business conduct.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Business conduct. 13.3 Section 13.3 Banks and....3 Business conduct. A bank that is a government securities broker or dealer shall observe high standards of commercial honor and just and equitable principles of trade in the conduct of its business as a...

F9 fimbriae of uropathogenic Escherichia coli are expressed at low temperature and recognise Galβ1-3GlcNAc-containing glycans.

Directory of Open Access Journals (Sweden)

Daniël J Wurpel

Full Text Available Uropathogenic Escherichia coli (UPEC is the leading causative agent of urinary tract infections (UTI in the developed world. Among the major virulence factors of UPEC, surface expressed adhesins mediate attachment and tissue tropism. UPEC strains typically possess a range of adhesins, with type 1 fimbriae and P fimbriae of the chaperone-usher class the best characterised. We previously identified and characterised F9 as a new chaperone-usher fimbrial type that mediates biofilm formation. However, the regulation and specific role of F9 fimbriae remained to be determined in the context of wild-type clinical UPEC strains. In this study we have assessed the distribution and genetic context of the f9 operon among diverse E. coli lineages and pathotypes and demonstrated that f9 genes are significantly more conserved in a UPEC strain collection in comparison to the well-defined E. coli reference (ECOR collection. In the prototypic UPEC strain CFT073, the global regulator protein H-NS was identified as a transcriptional repressor of f9 gene expression at 37°C through its ability to bind directly to the f9 promoter region. F9 fimbriae expression was demonstrated at 20°C, representing the first evidence of functional F9 fimbriae expression by wild-type E. coli. Finally, glycan array analysis demonstrated that F9 fimbriae recognise and bind to terminal Galβ1-3GlcNAc structures.

49 CFR 238.13 - Preemptive effect.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Preemptive effect. 238.13 Section 238.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION PASSENGER EQUIPMENT SAFETY STANDARDS General § 238.13 Preemptive effect. (a...

32 CFR 1602.13 - Judgmental Classification.

Science.gov (United States)

2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Judgmental Classification. 1602.13 Section 1602.13 National Defense Other Regulations Relating to National Defense SELECTIVE SERVICE SYSTEM DEFINITIONS § 1602.13 Judgmental Classification. A classification action relating to a registrant's claim for...

40 CFR 13.15 - Taxpayer information.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Taxpayer information. 13.15 Section 13.15 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL CLAIMS COLLECTION STANDARDS Collection § 13.15 Taxpayer information. (a) The Administrator may obtain a debtor's current mailing address...

9 CFR 354.13 - Supervision.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Supervision. 354.13 Section 354.13 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION VOLUNTARY INSPECTION OF RABBITS AND...

47 CFR 13.209 - Examination procedures.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Examination procedures. 13.209 Section 13.209 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS Examination System § 13.209 Examination procedures. (a) Each examination for a commercial radio operator license must be administered at a...

NCBI nr-aa BLAST: CBRC-TBEL-01-2529 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-TBEL-01-2529 ref|YP_001162719.1| 4-hydroxyphenylacetate permease [Yersinia pestis Pest...oides F] gb|ABP39746.1| 4-hydroxyphenylacetate permease [Yersinia pestis Pestoides F] YP_001162719.1 0.21 30% ...

21 CFR 516.13 - Definitions.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 6 2010-04-01 2010-04-01 false Definitions. 516.13 Section 516.13 Food and Drugs... Minor Species New Animal Drug § 516.13 Definitions. The following definitions of terms apply only in the... treatment, control or prevention of a disease or condition, or the intention to affect the structure or...

18 CFR 801.13 - Proviso.

Science.gov (United States)

2010-04-01

... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Proviso. 801.13 Section 801.13 Conservation of Power and Water Resources SUSQUEHANNA RIVER BASIN COMMISSION GENERAL POLICIES § 801.13 Proviso. (a) This part is promulgated pursuant to sections 3.1, 3.5(1), and 15.2 of the Compact...

10 CFR 11.13 - Special requirements for transportation.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Special requirements for transportation. 11.13 Section 11.13 Energy NUCLEAR REGULATORY COMMISSION CRITERIA AND PROCEDURES FOR DETERMINING ELIGIBILITY FOR... Authorization § 11.13 Special requirements for transportation. (a) All individuals who, after 365 days following...

13 CFR 108.520 - Management Expenses of a NMVC Company.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Management Expenses of a NMVC Company. 108.520 Section 108.520 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Managing the Operations of a NMVC Company Management and Compensation...

Tyndall AFB, Florida. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A-F.

Science.gov (United States)

1982-12-03

8.. 4𔃾. o.0I 44 ’ ’O 󈧤 I6F .3 16 .J PSYCHROMETRIC SUMMARY T-WET BULB TEM4PERATURE DEPRESION JF) TOTAL TOTAL F 0 1 2 3 4 5 6 8 9 T10 12 13 ]A 15 6...STATION VATON AM.3 WET BULB TEMPERATURE DEPRESION F1 TOTAL TOTAL (F) 0 1-2 3-4 5-6 7-. 9 10 11. 2 13 14 151. 6 17 1 19 20 21 22 23 24.25-26.27 2.29 30 31

48 CFR 13.202 - Purchase guidelines.

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Purchase guidelines. 13.202 Section 13.202 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING... Threshold 13.202 Purchase guidelines. (a) Solicitation, evaluation of quotations, and award. (1) To the...

13 CFR 120.620 - SBA guarantee of a Pool Certificate.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false SBA guarantee of a Pool Certificate. 120.620 Section 120.620 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Secondary Market The Sba Guarantee of A Certificate § 120.620 SBA guarantee of a Pool Certificate...

13 CFR 134.715 - Can a Judge reconsider his decision?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Can a Judge reconsider his decision? 134.715 Section 134.715 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF....715 Can a Judge reconsider his decision? (a) The Judge may reconsider an appeal decision within 20...

6 CFR 13.39 - Appeal to Authority Head.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Appeal to Authority Head. 13.39 Section 13.39 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.39 Appeal to Authority Head. (a) Any Defendant who has served a timely answer and who is...

6 CFR 13.18 - Authority of the ALJ.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Authority of the ALJ. 13.18 Section 13.18 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.18 Authority of the ALJ. (a) The ALJ will conduct a fair and impartial hearing, avoid delay...

30 CFR 402.13 - Program management.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Program management. 402.13 Section 402.13... WATER-RESOURCES TECHNOLOGY DEVELOPMENT PROGRAM Application, Evaluation, and Management Procedures § 402.13 Program management. (a) After the conclusion of negotiations, the USGS will transmit a grant or...

49 CFR 10.13 - Privacy Officer.

Science.gov (United States)

2010-10-01

... INDIVIDUALS General § 10.13 Privacy Officer. (a) To assist with implementation, evaluation, and administration issues, the Chief Information Officer appoints a principal coordinating official with the title Privacy... 49 Transportation 1 2010-10-01 2010-10-01 false Privacy Officer. 10.13 Section 10.13...

NCBI nr-aa BLAST: CBRC-CJAC-01-1322 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-CJAC-01-1322 ref|YP_001289349.1| PE-PGRS family protein [Mycobacterium tuberculosis... F11] gb|ABR07747.1| PE-PGRS family protein [Mycobacterium tuberculosis F11] YP_001289349.1 0.031 29% ...

NCBI nr-aa BLAST: CBRC-MLUC-01-1145 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-MLUC-01-1145 ref|NP_001041562.1| prostaglandin F receptor (FP) [Canis lupus fa...miliaris] gb|AAZ53353.1| prostaglandin F2-alpha receptor [Canis lupus familiaris] NP_001041562.1 0.0 93% ...

NCBI nr-aa BLAST: CBRC-CJAC-01-1322 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-CJAC-01-1322 ref|YP_001289305.1| PE-PGRS family protein [Mycobacterium tuberculosis... F11] gb|ABR07703.1| PE-PGRS family protein [Mycobacterium tuberculosis F11] YP_001289305.1 0.070 31% ...

13 CFR 120.1703 - Qualifications to be a Pool Originator.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Qualifications to be a Pool Originator. 120.1703 Section 120.1703 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Establishment of SBA Secondary Market Guarantee Program for First Lien Position 504 Loan Pools...

6 CFR 13.38 - Reconsideration of Initial Decision.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Reconsideration of Initial Decision. 13.38 Section 13.38 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.38 Reconsideration of Initial Decision. (a) Except as provided in paragraph (d) of...

7 CFR 1219.13 - Hass Avocado Board.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Hass Avocado Board. 1219.13 Section 1219.13... AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE HASS AVOCADO PROMOTION, RESEARCH, AND INFORMATION Hass Avocado Promotion, Research, and Information Order Definitions § 1219.13 Hass...

NCBI nr-aa BLAST: CBRC-CJAC-01-1605 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-CJAC-01-1605 ref|YP_001288442.1| PE-PGRS family protein [Mycobacterium tuberculosis... F11] gb|ABR06840.1| PE-PGRS family protein [Mycobacterium tuberculosis F11] YP_001288442.1 5e-07 36% ...

NCBI nr-aa BLAST: CBRC-BTAU-01-1564 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-BTAU-01-1564 ref|YP_001382287.1| ATP synthase F0 subunit 6 [Argopecten irradia...ns] gb|ABS17670.1| ATP synthase F0 subunit 6 [Argopecten irradians] YP_001382287.1 1.1 24% ...

NCBI nr-aa BLAST: CBRC-FCAT-01-0220 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-FCAT-01-0220 ref|YP_026082.1| ATP synthase F0 subunit 6 [Steinernema carpocaps...ae] gb|AAT00525.1| ATP synthase F0 subunit 6 [Steinernema carpocapsae] YP_026082.1 0.004 23% ...

NCBI nr-aa BLAST: CBRC-ETEL-01-0643 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-ETEL-01-0643 ref|NP_001041562.1| prostaglandin F receptor (FP) [Canis lupus fa...miliaris] gb|AAZ53353.1| prostaglandin F2-alpha receptor [Canis lupus familiaris] NP_001041562.1 1e-131 95% ...

NCBI nr-aa BLAST: CBRC-FCAT-01-0804 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-FCAT-01-0804 ref|YP_073313.1| ATP synthase F0 subunit 6 [Neomaskellia andropog...onis] gb|AAS75439.1| ATP synthase F0 subunit 6 [Neomaskellia andropogonis] YP_073313.1 1.8 24% ...

NCBI nr-aa BLAST: CBRC-DNOV-01-1349 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-DNOV-01-1349 ref|YP_073313.1| ATP synthase F0 subunit 6 [Neomaskellia andropog...onis] gb|AAS75439.1| ATP synthase F0 subunit 6 [Neomaskellia andropogonis] YP_073313.1 1.8 25% ...

NCBI nr-aa BLAST: CBRC-DNOV-01-2699 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-DNOV-01-2699 ref|YP_073313.1| ATP synthase F0 subunit 6 [Neomaskellia andropog...onis] gb|AAS75439.1| ATP synthase F0 subunit 6 [Neomaskellia andropogonis] YP_073313.1 0.055 30% ...

NCBI nr-aa BLAST: CBRC-OCUN-01-0782 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-OCUN-01-0782 ref|YP_073313.1| ATP synthase F0 subunit 6 [Neomaskellia andropog...onis] gb|AAS75439.1| ATP synthase F0 subunit 6 [Neomaskellia andropogonis] YP_073313.1 1.9 26% ...

NCBI nr-aa BLAST: CBRC-FCAT-01-0019 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-FCAT-01-0019 ref|NP_001041562.1| prostaglandin F receptor (FP) [Canis lupus fa...miliaris] gb|AAZ53353.1| prostaglandin F2-alpha receptor [Canis lupus familiaris] NP_001041562.1 1e-121 96% ...

40 CFR 610.13 - Program structure.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Program structure. 610.13 Section 610.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) ENERGY POLICY FUEL ECONOMY RETROFIT DEVICES Test Procedures and Evaluation Criteria General Provisions § 610.13 Program structure. (a...

49 CFR 219.13 - Preemptive effect.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Preemptive effect. 219.13 Section 219.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CONTROL OF ALCOHOL AND DRUG USE General § 219.13 Preemptive effect. (a) Under...

49 CFR 371.13 - Accounting.

Science.gov (United States)

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Accounting. 371.13 Section 371.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS BROKERS OF PROPERTY § 371.13 Accounting...

40 CFR 406.13 - [Reserved

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 406.13 Section 406.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Wet Milling Subcategory § 406.13 [Reserved] ...

13 CFR 120.801 - How a 504 Project is financed.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How a 504 Project is financed. 120.801 Section 120.801 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company Loan Program (504) § 120.801 How a 504 Project is financed. (a) One or more small...

Academic Training - 2nd Term: 08.01.2007 - 31.03.2007

CERN Multimedia

2006-01-01

2006 - 2007 ACADEMIC TRAINING PROGRAMME 2nd Term : 08.01.2007 - 31.03.2007 LECTURE SERIES Applied Superconductivity by V. Palmieri, INFN, Padova, It. 17, 18, 19 January 11:00 -1200 - Auditorium, Bldg 500 String Theory for Pedestrians by B. Zwiebach, M.I.T. Cambridge, USA 29, 30, 31 January 11:00-12:00 - Auditorium, Bldg 500 on 29, 30 January TH Auditorium on 31 January Introduction to Supersymmetry by D. Kaplan, John Hopkins University, Baltimore, USA 12, 13, 14, 15 February 11:00-12:00 - Auditorium, Bldg 500 The Hunt for the Higgs Particle by F. Zwirner, University of Padova, It 27, 28 February, 1st March 11:00-12:00 - Auditorium, Bldg 500 From Evolution Theory to Parallel and Distributed Genetic by F. Fernandez de Vega 15, 16, March 11:00-12:00 - Auditorium, Bldg 500 The lectures are open to all those interested, without application. The abstract of the lectures, as well as any change to the above information (title, dates, time, place etc.) will be published in the CERN bulletin, the WWW, an...

Academic Training - 2nd Term: 08.01.2007 - 31.03.2007

CERN Multimedia

2006-01-01

2006 - 2007 ACADEMIC TRAINING PROGRAMME 2nd Term : 08.01.2007 - 31.03.2007 LECTURE SERIES Applied Superconductivity by V. Palmieri, INFN, Padova, It. 17, 18, 19 January 11:00 -1200 - Auditorium, bldg. 500 String Theory for Pedestrians by B. Zwiebach, M.I.T. Cambridge, USA 29, 30, 31 January 11:00-12:00 - Auditorium, bldg. 500 on 29, 30 January TH Auditorium on 31 January Introduction to Supersymmetry by D. Kaplan, John Hopkins University, Baltimore, USA 12, 13, 14, 15 February 11:00-12:00 - Auditorium, bldg. 500 The Hunt for the Higgs Particle by F. Zwirner, University of Padova, It 27, 28 February, 1st March 11:00-12:00 - Auditorium, bldg. 500 From Evolution Theory to Parallel and Distributed Genetic Programming by F. Fernandez de Vega 15, 16, March 11:00-12:00 - Auditorium, bldg. 500 The lectures are open to all those interested, without application. The abstract of the lectures, as well as any change to the above information (title, dates, time, place etc.) will be published in the WWW, and ...

14 CFR 99.13 - Transponder-on requirements.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Transponder-on requirements. 99.13 Section 99.13 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR TRAFFIC AND GENERAL OPERATING RULES SECURITY CONTROL OF AIR TRAFFIC General § 99.13 Transponder-on...

[18F]fluoromethylated phenyl-pyrroles and 7-azaindole analog as potential dopamine D4 receptor imaging agents

International Nuclear Information System (INIS)

Ji, D. Y.; Oh, S. Z.; Choi, Y. S.; Lee, K. C.; Kim, S. E.; Choi, Y.; Lee, K. H.; Kim, B. T.

1997-01-01

An association between the dopamine D 4 receptor and schizophrenia was recently suggested and the D 4 receptor antagonists may thus have potential in elucidating the role of the receptor in schizophrenic patients. The purpose of this study was to develop some of these antagonists as potential dopamine D 4 receptor imaging agents for PET. We have prepared 1-(3-[ 18 F]fluoromethylphenyl)-3-([4-(pyridin-2-yl)piperazin-1-yl)methyl) pyrrole (1), 1-(3-[ 18 F]fluoromethylphenyl)-3-([4-(pyridin-2-yl)piperazin-1-yl)methyl) pyrrole (2), and 3-([4-(4-[ 18 F]fluoro methylbenzyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3,-b)pyridine (3) as potential imaging agents for the dopamine D 4 receptor for PET. The compounds [ 18 F]1 and [ 18 F]2 were prepared by coupling of (3-[ 18 F]fluoromethylphenyl)-pyrrol-1- yl-3-aldehyde and the piperazine moiety in the presence of NaBH 3 CN. The [ 18 F]fluorinated aldehyde was obtained in 60-85% yield by the displacement of the corresponding mesylate with F-18-(THF, 90 .deg. C, 5 min). HPLC purification (Alltech Econosil C-18 columm, 250 x 10 mm, 35: 65 = 0.1M NH 4 CI 2 H : CH 3 OH, 4 ml/min, t R =26.6 min) gave the [ 18 F]1 and [ 18 F]2 in 7-12% yield. In the case of azaindole 3, a methlene link was inserted between the piperazinyl and a fluoromethyl phenyl group. Radiochemical synthesis of the [ 18 F]3 was carried out by coupling of the piperazne moiety and [ 18 F]fluoromethylbenzyl mesylate in the presence of NEt 3 (3:1-CH 3 CN: DMF, 120 .deg. C, 30 min). Purification was carried out by HPLC using a C-18 column (Alltech Econosil, 50 x 10 mm, 100% 0.1M NH 4 CO 2 H for 5 min followed by 40:60=0.1 M NH 4 CO 2 H : MeOH, 4 ml/min t R =28.7 min). The time of synthesis including HPLC purification was 100 min. The overall yield of [ 18 F]3 was 10-15% with a radiochemical purity better than 97% and a specific activity greater than 1000 ci/mmol

19 CFR 191.13 - Packaging materials.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 2 2010-04-01 2010-04-01 false Packaging materials. 191.13 Section 191.13 Customs... (CONTINUED) DRAWBACK General Provisions § 191.13 Packaging materials. (a) Imported packaging material... packaging material when used to package or repackage merchandise or articles exported or destroyed pursuant...

47 CFR 13.17 - Replacement license.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Replacement license. 13.17 Section 13.17 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS General § 13.17 Replacement... request a replacement. The application must be accompanied by the required fee and submitted to the...

45 CFR 1170.13 - Illustrative examples.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Illustrative examples. 1170.13 Section 1170.13... ASSISTED PROGRAMS OR ACTIVITIES Discrimination Prohibited § 1170.13 Illustrative examples. (a) The following examples will illustrate the application of the foregoing provisions to some of the activities...

22 CFR 171.13 - Business information.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Business information. 171.13 Section 171.13 Foreign Relations DEPARTMENT OF STATE ACCESS TO INFORMATION AVAILABILITY OF INFORMATION AND RECORDS TO THE PUBLIC Freedom of Information Act Provisions § 171.13 Business information. (a) Business information...

32 CFR 705.13 - Commercial advertising.

Science.gov (United States)

2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Commercial advertising. 705.13 Section 705.13... AND OFFICIAL RECORDS PUBLIC AFFAIRS REGULATIONS § 705.13 Commercial advertising. (a) The Navy... personnel, facilities, equipment or supplies for advertising purposes must be referred to the Chief of...

49 CFR 232.13 - Preemptive effect.

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Preemptive effect. 232.13 Section 232.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... EQUIPMENT; END-OF-TRAIN DEVICES General § 232.13 Preemptive effect. (a) Under 49 U.S.C. 20106, issuance of...

46 CFR 160.017-13 - Construction.

Science.gov (United States)

2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Construction. 160.017-13 Section 160.017-13 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) EQUIPMENT, CONSTRUCTION, AND MATERIALS: SPECIFICATIONS AND APPROVAL LIFESAVING EQUIPMENT Chain Ladder § 160.017-13 Construction. (a) General. Each chain...

7 CFR 318.13-22 - Bananas from Hawaii.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Bananas from Hawaii. 318.13-22 Section 318.13-22... SERVICE, DEPARTMENT OF AGRICULTURE STATE OF HAWAII AND TERRITORIES QUARANTINE NOTICES Regulated Articles From Hawaii and the Territories § 318.13-22 Bananas from Hawaii. (a) Green bananas (Musa spp.) of the...

49 CFR 260.13 - Credit reform.

Science.gov (United States)

2010-10-01

... appropriations, direct payment of a Credit Risk Premium by the Applicant or a non-Federal infrastructure partner... 49 Transportation 4 2010-10-01 2010-10-01 false Credit reform. 260.13 Section 260.13... REHABILITATION AND IMPROVEMENT FINANCING PROGRAM Overview § 260.13 Credit reform. The Federal Credit Reform Act...

12 CFR Appendix F to Part 360 - Customer File Structure

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Customer File Structure F Appendix F to Part... POLICY RESOLUTION AND RECEIVERSHIP RULES Pt. 360, App. F Appendix F to Part 360—Customer File Structure This is the structure of the data file to provide to the FDIC information related to each customer who...

NCBI nr-aa BLAST: CBRC-TTRU-01-1294 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-TTRU-01-1294 ref|NP_051157.1| ATP synthase F0 subunit 6 [Cafeteria roenbergens...is] gb|AAF05808.1|AF193903_31 ATP synthase F0 subunit 6 [Cafeteria roenbergensis] NP_051157.1 0.057 29% ...

NCBI nr-aa BLAST: CBRC-DNOV-01-0972 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-DNOV-01-0972 ref|NP_051157.1| ATP synthase F0 subunit 6 [Cafeteria roenbergens...is] gb|AAF05808.1|AF193903_31 ATP synthase F0 subunit 6 [Cafeteria roenbergensis] NP_051157.1 0.001 29% ...

Ff-nano, Short Functionalized Nanorods Derived from Ff (f1, fd or M13 Filamentous Bacteriophage

Directory of Open Access Journals (Sweden)

Sadia eSattar

2015-04-01

Full Text Available F-specific filamentous phage of Escherichia coli (Ff: f1, M13 or fd are long thin filaments (860 nm x 6 nm. They have been a major workhorse in display technologies and bionanotechnology; however, some applications are limited by the high length-to-diameter ratio of Ff. Furthermore, use of functionalized Ff outside of laboratory containment is in part hampered by the fact that they are genetically modified viruses. We have now developed a system for production and purification of very short functionalized Ff-phage-derived nanorods, named Ff-nano, that are only 50 nm in length. In contrast to standard Ff-derived vectors that replicate in E. coli and contain antibiotic-resistance genes, Ff-nano are protein DNA complexes that cannot replicate on their own and do not contain any coding sequences. These nanorods show an increased resistance to heating at 70 °C in 1 % SDS in comparison to the full-length Ff phage of the same coat composition. We demonstrate that functionalized Ff-nano particles are suitable for application as detection particles in sensitive and quantitative dipstick lateral flow diagnostic assay for human plasma fibronectin.

13 CFR 120.520 - Purchase of 7(a) loan guarantees.

Science.gov (United States)

2010-01-01

... condition of the collateral, plans for any type of loan workout or loan restructuring, existing liquidation activities including the sale of loan collateral, or the status of ongoing foreclosure proceedings. The... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Purchase of 7(a) loan guarantees...

46 CFR Sec. 13 - Insurance.

Science.gov (United States)

2010-10-01

... REPAIRS UNDER NATIONAL SHIPPING AUTHORITY MASTER LUMP SUM REPAIR CONTRACT-NSA-LUMPSUMREP Sec. 13 Insurance. Article 9 of the NSA-LUMPSUMREP Contract sets forth the Contractor's liabilities and obligations with... 46 Shipping 8 2010-10-01 2010-10-01 false Insurance. Sec. 13 Section 13 Shipping MARITIME...

34 CFR 300.13 - Elementary school.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Elementary school. 300.13 Section 300.13 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.13 Elementary school. Elementary school means a...

19 CFR 210.13 - The response.

Science.gov (United States)

2010-04-01

... 19 Customs Duties 3 2010-04-01 2010-04-01 false The response. 210.13 Section 210.13 Customs Duties UNITED STATES INTERNATIONAL TRADE COMMISSION INVESTIGATIONS OF UNFAIR PRACTICES IN IMPORT TRADE ADJUDICATION AND ENFORCEMENT Pleadings § 210.13 The response. (a) Time for response. Except as provided in...

7 CFR 93.13 - Analytical methods.

Science.gov (United States)

2010-01-01

... No. 1, USDA, Agricultural Marketing Service, Science and Technology, 3521 South Agriculture Building... 7 Agriculture 3 2010-01-01 2010-01-01 false Analytical methods. 93.13 Section 93.13 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards...

12 CFR 508.13 - Decision of the Office.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Decision of the Office. 508.13 Section 508.13 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.13 Decision of the Office. (a) Within 30 days after the recommended decision has been certifie...

5-tert-Butyl-2-(4'-[{sup 18}F]fluoropropynylphenyl)-1,3-dithiane oxides: potential new GABA{sub A} receptor radioligands

Energy Technology Data Exchange (ETDEWEB)

Li Xuehe; Jung, Yong-Woon; Snyder, Scott E.; Blair, Joseph; Sherman, Philip S.; Desmond, Timothy; Frey, Kirk A. [Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109 (United States); Kilbourn, Michael R. [Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109 (United States)], E-mail: mkilbour@umich.edu

2008-07-15

As potential new ligands targeting the binding site of {gamma}-aminobutyric acid (GABA) receptor ionophore, trans-5-tert-butyl-2-(4'-fluoropropynylphenyl)-2-methyl-1,1-dioxo-1, 3-dithiane (1) and cis/trans-5-tert-butyl-2-(4'-fluoropropynylphenyl)-2-methyl-1,1,3, 3-tetroxo-1,3-dithiane (2) were selected for radiolabeling and initial evaluation as in vivo imaging agents for positron emission tomography (PET). Both compounds exhibited identical high in vitro binding affinities (K{sub i}=6.5 nM). Appropriate tosylate-substituted ethynyl precursors were prepared by multistep syntheses involving stepwise sulfur oxidation and chromatographic isolation of desired trans isomers. Radiolabeling was accomplished in one step using nucleophilic [{sup 18}F]fluorination. In vivo biodistribution studies with trans-[{sup 18}F]1 and trans-[{sup 18}F]2 showed significant initial uptake into mouse brain and gradual washout, with heterogeneous regional brain distributions and higher retention in the cerebral cortex and cerebellum and lower retention in the striatum and pons-medulla. These regional distributions of the new radioligands correlated with in vitro and ex vivo measures of standard radioligands binding to the ionophore- and benzodiazepine-binding sites of GABA{sub A} receptor in rodent brain. A comparison of these results with previously prepared radiotracers for other neurochemical targets, including successes and failures as in vivo radioligands, suggests that higher-affinity compounds with increased retention in target brain tissues will likely be needed before a successful radiopharmaceutical for human PET imaging can be identified.

7 CFR 15f.11 - Where must I file a hearing request and what happens to it?

Science.gov (United States)

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Where must I file a hearing request and what happens to it? 15f.11 Section 15f.11 Agriculture Office of the Secretary of Agriculture ADJUDICATIONS UNDER... must I file a hearing request and what happens to it? If you desire a hearing, you must file a request...

7 CFR 318.13-5 - Pest-free areas.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Pest-free areas. 318.13-5 Section 318.13-5 Agriculture... and the Territories § 318.13-5 Pest-free areas. Certain fruits or vegetables may be moved interstate provided that the fruits or vegetables originate from an area that is free of a specific pest or pests. In...

12 CFR 563f.1 - Authority, purpose, and scope.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Authority, purpose, and scope. 563f.1 Section... INTERLOCKS § 563f.1 Authority, purpose, and scope. (a) Authority. This part is issued under the provisions of... generally prohibiting a management official from serving two nonaffiliated depository organizations in...

26 CFR 1.860F-1 - Qualified liquidations.

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Qualified liquidations. 1.860F-1 Section 1.860F-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.860F-1 Qualified liquidations. A plan of...

NCBI nr-aa BLAST: CBRC-XTRO-01-0459 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-XTRO-01-0459 ref|YP_438260.1| transporter, AcrB/D/F family [Burkholderia thailand...ensis E264] gb|ABC35049.1| transporter, AcrB/D/F family [Burkholderia thailandensis E264] YP_438260.1 0.0 70% ...

15 CFR 90.13 - Offer of hearing.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Offer of hearing. 90.13 Section 90.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade BUREAU OF THE CENSUS, DEPARTMENT OF COMMERCE PROCEDURE FOR CHALLENGING CERTAIN POPULATION AND INCOME ESTIMATES § 90.13 Offer of...

6 CFR 13.36 - Post-hearing briefs.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Post-hearing briefs. 13.36 Section 13.36 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.36 Post-hearing briefs. The ALJ may require the parties to file post-hearing briefs. In any event...

36 CFR 13.1232 - Sanitation.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Sanitation. 13.1232 Section 13.1232 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR... Developed Area § 13.1232 Sanitation. Within the BCDA, washing dishes or cooking utensils at locations other...

49 CFR 397.13 - Smoking.

Science.gov (United States)

2010-10-01

... 49 Transportation 5 2010-10-01 2010-10-01 false Smoking. 397.13 Section 397.13 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL MOTOR CARRIER SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION FEDERAL MOTOR CARRIER SAFETY REGULATIONS TRANSPORTATION OF HAZARDOUS MATERIALS; DRIVING AND PARKING RULES General § 397.13...

22 CFR 126.13 - Required information.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Required information. 126.13 Section 126.13... PROVISIONS § 126.13 Required information. (a) All applications for licenses (DSP-5, DSP-61, DSP-73, and DSP... are multiple consignors, consignees or freight forwarders, and all the required information cannot be...

Study to master "1"8F-FDG radiopharmaceutical production process by Korean Cyclotron KOTRONS 13 MeV at Hanoi Irradiation Center

International Nuclear Information System (INIS)

Nguyen Quang Anh; Tran Manh Thang; Dam Thi Tam; Mai Van Vinh

2016-01-01

A PET Cyclotron center is built in Hanoi Irradiation Center (HIC), VINATOM and expectation put in operation in the middle of 2016. Three main processes in "1"8F-FDG synthesis general process of Samyoung Unitech synthesizer module were studied as: effect of time to water removal process, effect of time to nucleophilic substitution reaction, and effect of temperature and time to hydrolysis process. The optimum parameters are collected and re-installed for "1"8F-FDG synthesizer module to achieve highest yield. The human resource was trained basic to advanced theoretical and practical training programs of 18F-FDG Radiopharmaceutical Production by Vietnamese and Korean senior experts in HICs facility for this project. After training courses, the human resource is able to produce and quality control "1"8F-FDG Radiopharmaceutical in different modules and quality control systems such as GE-MX (GE), Synthera (IBA), and Samyoung Unitech (SYU). "1"8F-FDG Radiopharmaceutical was produced in HIC achieves British Pharmacopeia (BP) standards and tested in animals. Animal PET/CT scanner images show clearly distribution of FDG according to physiological characters. Besides, this project were establishing "1"8F-FDG Radiopharmaceutical Production Process by cyclotron KOTRONS13 and Samyoung Unitech synthesizer module and Quality Assurance, Quality Control Process attain BP standards at Hanoi Irradiation Center; and establishing the training documents for practical production human resource training, "1"8F-FDG radiopharmaceutical Quality Assurance Process, Quality Control Process which attain BP standards. (author)

The receptor locus for escherichia coli F4ab/F4ac in the pig maps distal to the MUC4-LMLN region

DEFF Research Database (Denmark)

Rampoldi, Antonio; Jacobsen, Mette Juul; Bertschinger, Hans U.

2011-01-01

antigenic variants, F4ab, F4ac, and F4ad, of which F4ac is the most common. Resistance to ETEC F4ab/F4ac adhesion in pigs has been shown to be inherited as an autosomal recessive trait. In previous studies the ETEC F4ab/F4ac receptor locus (F4bcR) was mapped to the q41 region on pig chromosome 13....... A polymorphism within an intron of the mucin 4 (MUC4) gene, which is one of the possible candidate genes located in this region, was shown earlier to cosegregate with the F4bcR alleles. Recently, we discovered a Large White boar from a Swiss experimental herd with a recombination between F4bcR and MUC4. A three...... a newly detected SNP in the leishmanolysin-like gene (LMLN g.15920) and SNP ALGA0072075. In this study the six SNPs ALGA0072075, ALGA0106330, MUC13-226, MUC13-813, DIA0000584, and MARC0006918 were in complete linkage disequilibrium with F4bcR. Based on this finding and earlier investigations, we suggest...

40 CFR 13.39 - Agency determination.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Agency determination. 13.39 Section 13... Referral of Debts to IRS for Tax Refund Offset § 13.39 Agency determination. (a) Following review of the evidence, EPA will issue a written decision. (b) If EPA either sustains or amends its determination, it...

40 CFR 258.13 - Fault areas.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Fault areas. 258.13 Section 258.13... SOLID WASTE LANDFILLS Location Restrictions § 258.13 Fault areas. (a) New MSWLF units and lateral expansions shall not be located within 200 feet (60 meters) of a fault that has had displacement in Holocene...

7 CFR 1770.13 - Accounting requirements.

Science.gov (United States)

2010-01-01

... accrual basis of accounting. All transactions shall be recorded in the period in which they occur and... 7 Agriculture 12 2010-01-01 2010-01-01 false Accounting requirements. 1770.13 Section 1770.13... AGRICULTURE (CONTINUED) ACCOUNTING REQUIREMENTS FOR RUS TELECOMMUNICATIONS BORROWERS Uniform System of...

6 CFR 13.15 - Ex parte contacts.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Ex parte contacts. 13.15 Section 13.15 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.15 Ex parte contacts. No party or Person (except employees of the ALJ's office) will communicate in any way...

36 CFR 1002.13 - Fires.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Fires. 1002.13 Section 1002... § 1002.13 Fires. (a) The following are prohibited: (1) Lighting or maintaining a fire, except in... or lanterns in violation of established restrictions. (3) Lighting, tending, or using a fire, stove...

Presurgical motor, somatosensory and language fMRI: Technical feasibility and limitations in 491 patients over 13 years

International Nuclear Information System (INIS)

Tyndall, Anthony J.; Reinhardt, Julia; Stippich, Christoph; Tronnier, Volker; Mariani, Luigi

2017-01-01

To analyse the long-term feasibility and limitations of presurgical fMRI in a cohort of tumour and epilepsy patients with different MR-scanners at 1.5 and 3.0 T. Four hundred and ninety-one consecutive patients undergoing presurgical fMRI between 2000 and 2012 on five different MR-scanners using established paradigms and semi-automated data processing were included. Success rates of task performance and BOLD-activation were determined for motor and somatosensory somatotopic mapping and language localisation. Procedural success, failures and imaging artifacts were analysed. MR-field strengths were compared. Two thousand three hundred fifteen of 2348 (98.6 %) attempted paradigms (1033 motor, 1220 speech, 95 somatosensory) were successfully performed. 100 paradigms (4.3 %) were repetition runs. 23 speech, 6 motor and 2 sensory paradigms failed for non-compliance and technical issues. Most language paradigm failures were noted in overt sentence generation. Average significant BOLD-activation was higher for motor than language paradigms (95.8 vs. 81.6 %). Most language paradigms showed significantly higher activation rates at 3 T compared to 1.5 T, whereas no significant difference was found for motor paradigms. fMRI proved very robust for the presurgical localisation of the different motor and somatosensory body representations, as well as Broca's and Wernicke's language areas across different MR-scanners at 1.5 and 3.0 T over 13 years. (orig.)

Presurgical motor, somatosensory and language fMRI: Technical feasibility and limitations in 491 patients over 13 years

Energy Technology Data Exchange (ETDEWEB)

Tyndall, Anthony J.; Reinhardt, Julia; Stippich, Christoph [University Hospital Basel, Division of Diagnostic and Interventional Neuroradiology, Basel (Switzerland); Tronnier, Volker [University Hospital Schleswig-Holstein, Luebeck Campus, Department of Neurosurgery, Luebeck (Germany); Mariani, Luigi [University Hospitals Basel, Department of Neurosurgery, Basel (Switzerland)

2017-01-15

To analyse the long-term feasibility and limitations of presurgical fMRI in a cohort of tumour and epilepsy patients with different MR-scanners at 1.5 and 3.0 T. Four hundred and ninety-one consecutive patients undergoing presurgical fMRI between 2000 and 2012 on five different MR-scanners using established paradigms and semi-automated data processing were included. Success rates of task performance and BOLD-activation were determined for motor and somatosensory somatotopic mapping and language localisation. Procedural success, failures and imaging artifacts were analysed. MR-field strengths were compared. Two thousand three hundred fifteen of 2348 (98.6 %) attempted paradigms (1033 motor, 1220 speech, 95 somatosensory) were successfully performed. 100 paradigms (4.3 %) were repetition runs. 23 speech, 6 motor and 2 sensory paradigms failed for non-compliance and technical issues. Most language paradigm failures were noted in overt sentence generation. Average significant BOLD-activation was higher for motor than language paradigms (95.8 vs. 81.6 %). Most language paradigms showed significantly higher activation rates at 3 T compared to 1.5 T, whereas no significant difference was found for motor paradigms. fMRI proved very robust for the presurgical localisation of the different motor and somatosensory body representations, as well as Broca's and Wernicke's language areas across different MR-scanners at 1.5 and 3.0 T over 13 years. (orig.)

32 CFR 751.13 - Partial payments.

Science.gov (United States)

2010-07-01

... voucher and all other information related to the partial payment shall be placed in the claim file. Action... 32 National Defense 5 2010-07-01 2010-07-01 false Partial payments. 751.13 Section 751.13 National... Claims Against the United States § 751.13 Partial payments. (a) Partial payments when hardship exists...

25 CFR 151.13 - Title examination.

Science.gov (United States)

2010-04-01

... 25 Indians 1 2010-04-01 2010-04-01 false Title examination. 151.13 Section 151.13 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER LAND ACQUISITIONS § 151.13 Title examination. If the Secretary determines that he will approve a request for the acquisition of land from...

SU-C-BRA-01: 18F-NaF PET/CT-Directed Dose Escalation in Stereotactic Body Radiotherapy for Spine Oligometastases From Prostate Cancer

Energy Technology Data Exchange (ETDEWEB)

Wu, L [Cancer Hospital of Shantou University Medical College, Shantou, Guangdong (China); University of Nevada, Las Vegas, Las Vegas, NV (United States); Zhang, W; Li, M; Peng, X; Xie, L; Lin, Z [Cancer Hospital of Shantou University Medical College, Shantou, Guangdong (China); Kwee, S [The Queen’s Medical Center, Honolulu, HI (United States); Wang, H; Kuang, Y [University of Nevada, Las Vegas, Las Vegas, NV (United States)

2015-06-15

Purpose: To investigate the technical feasibility of SBRT dose painting using {sup 18}F-NaF positron emission tomography (PET) scans guidance in patients with spine oligometastases from prostate cancer. Methods: As a proof of concept, six patients with 14 spine oligometastatic lesions from prostate cancer who had {sup 18}F-NaF PET/CT scan prior to treatment were retrospectively included. GTV{sub reg} was delineated according to the regular tumor boundary shown on PET and/or CT images; and GTV{sub MATV} was contoured based on a net metabolically active tumor volume (MATV) defined by 60% of the SUV{sub max} values on {sup 18}F-NaF PET images. The PTVs (PTV{sub reg} and PTV{sub MATV}) were defined as respective GTVs (plus involved entire vertebral body for PTV{sub reg}) with a 3-mm isotropic expansion margin. Three 1-fraction SBRT plans using VMAT technique along with 10 MV FFF beams (Plan{sub 24Gy}, Plan{sub 24–27Gy}, and Plan{sub 24–30Gy}) were generated for each patient. All plans included a dose of 24 Gy prescribed to PTV{sub reg}. The Plan{sub 24–27Gy} and Plan{sub 24–30Gy} also included a simultaneous boost dose of 27 Gy or 30 Gy prescribed to the PTV{sub MATV}, respectively. The feasibility of 18F-NaF PET-guided SBRT dose escalation was evaluated by its ability to achieve the prescription dose objectives while adhering to organ-at-risk (OAR) dose constraints. The normal tissue complication probabilities (NTCP) calculated by radiological models were also compared between the plans. Results: In all 33 SBRT plans generated, the planning objectives and dose constraints were met without exception. Plan{sub 24–27Gy} and Plan{sub 24–30Gy} had a significantly higher dose in PTV{sub MATV} than Plan{sub 24Gy} (p < 0.05), respectively, while maintaining a similar OAR sparing profile and NTCP values. Conclusion: Using VMAT with FFF beams to incorporate a simultaneous {sup 18}F-NaF PET-guided radiation boost dose up to 30 Gy into a SBRT plan is technically

8 CFR 236.13 - Ineligible aliens.

Science.gov (United States)

2010-01-01

... 8 Aliens and Nationality 1 2010-01-01 2010-01-01 false Ineligible aliens. 236.13 Section 236.13 Aliens and Nationality DEPARTMENT OF HOMELAND SECURITY IMMIGRATION REGULATIONS APPREHENSION AND DETENTION OF INADMISSIBLE AND DEPORTABLE ALIENS; REMOVAL OF ALIENS ORDERED REMOVED Family Unity Program § 236...

15 CFR 785.13 - Procedural stipulations.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Procedural stipulations. 785.13 Section 785.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE ADDITIONAL PROTOCOL REGULATIONS ENFORCEMENT § 785...

12 CFR 13.5 - Customer information.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Customer information. 13.5 Section 13.5 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY GOVERNMENT SECURITIES SALES...) The customer's investment objectives; and (d) Such other information used or considered to be...

17 CFR 240.16a-13 - Change in form of beneficial ownership.

Science.gov (United States)

2010-04-01

... exercise or conversion of a derivative security or deposit into or withdrawal from a voting trust, that... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Change in form of beneficial ownership. 240.16a-13 Section 240.16a-13 Commodity and Securities Exchanges SECURITIES AND EXCHANGE...

6 CFR 13.23 - Subpoenas for attendance at hearing.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Subpoenas for attendance at hearing. 13.23 Section 13.23 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.23 Subpoenas for attendance at hearing. (a) A party wishing to procure the...

Preliminary Results of IS Plasma Focus as a Breeder of Short-Lived Radioisotopes 12C(d,n)13N

Science.gov (United States)

Sadat Kiai, S. M.; Elahi, M.; Adlparvar, S.; Shahhoseini, E.; Sheibani, S.; Ranjber akivaj, H.; Alhooie, S.; Safarien, A.; Farhangi, S.; Aghaei, N.; Amini, S.; Khalaj, M. M.; Zirak, A. R.; Dabirzadeh, A. A.; Soleimani, J.; Torkzadeh, F.; Mousazadeh, M. M.; Moradi, K.; Abdollahzadeh, M.; Talaei, A.; Zaeem, A. A.; Moslehi, A.; Kashani, A.; Babazadeh, A. R.; Bagiyan, F.; Ardestani, M.; Roozbahani, A.; Pourbeigi, H.; Tajik Ahmadi, H.; Ahmadifaghih, M. A.; Mahlooji, M. S.; Mortazavi, B. N.; Zahedi, F.

2011-04-01

Modified IS (Iranian Sun) plasma focus (10 kJ,15 kV, 94 μF, 0.1 Hz) has been used to produce the short-lived radioisotope 13N (half-life of 9.97 min) through 12C(d,n)13N nuclear reaction. The filling gas was 1.5-3 torr of hydrogen (60%) deuterium (40%) mixture. The target was solid nuclear grade graphite with 5 mm thick, 9 cm width and 13 in length. The activations of the exogenous target on average of 20 shots (only one-third acceptable) through 10-13 kV produced the 511 keV gamma rays. Another peak found at the 570 keV gamma of which both was measured by a NaI portable gamma spectrometer calibrated by a 137Cs 0.25 μCi sealed reference source with its single line at 661.65 keV and 22Na 0.1 μCi at 511 keV. To measure the gamma rays, the graphite target converts to three different phases; solid graphite, powder graphite, and powder graphite in water solution. The later phase approximately has a doubled activity with respect to the solid graphite target up to 0.5 μCi of 511 keV and 1.1 μCi of 570 keV gamma lines were produced. This increment in activity was perhaps due to structural transformation of graphite powder to nano-particles characteristic in liquid water.

Superconductivity of Hg3NbF6 and Hg3TaF6

International Nuclear Information System (INIS)

Datars, W.R.; Morgan, K.R.; Gillespie, R.J.

1983-01-01

Low-temperature ac susceptibility measurements show that two new metallic compounds, Hg 3 TaF 6 and Hg 3 NbF 6 , are superconductors with a critical temperature of 7.0 K. Critical fields are 20% higher in Hg 3 TaF 6 but the temperature dependence of the critical field of the compounds is very similar down to 1.35 K. The critical field extrapolated to T = 0 K is 0.17 T for Hg 3 TaF 6 and 0.13 T for Hg 3 NbF 6

Water physics and chemistry data from bottle casts from the MAURY and other platforms from 01 July 1949 to 13 August 1982 (NODC Accession 8500022)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Water physics and chemistry data were collected from bottle casts from the MAURY and other platforms from 01 July 1949 to 13 August 1982. Data were submitted by...

36 CFR 13.905 - Group size.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Group size. 13.905 Section 13... § 13.905 Group size. (a) The following are prohibited: (1) Group sizes exceeding 12 individuals on the east side of the park outside the Frontcountry Developed Area as defined by this subpart. (2) Group...

13 CFR 108.1900 - Termination of participation as a NMVC Company.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Termination of participation as a NMVC Company. 108.1900 Section 108.1900 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW MARKETS VENTURE CAPITAL (âNMVCâ) PROGRAM Ending Operations as a NMVC Company § 108.1900...

45 CFR 99.13 - Place.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 1 2010-10-01 2010-10-01 false Place. 99.13 Section 99.13 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROCEDURE FOR HEARINGS FOR THE CHILD CARE AND DEVELOPMENT FUND Preliminary Matters-Notice and Parties § 99.13 Place. The hearing shall be held in the city...

31 CFR 346.13 - Taxation.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Taxation. 346.13 Section 346.13 Money... BONDS § 346.13 Taxation. The tax treatment provided under section 409 of the Internal Revenue Code of..., inheritance, or other excise taxes, whether Federal or State, but are exempt from all taxation now or...

31 CFR 341.13 - Taxation.

Science.gov (United States)

2010-07-01

... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Taxation. 341.13 Section 341.13 Money... § 341.13 Taxation. The tax treatment provided under section 405 of the Internal Revenue Code of 1954... taxes whether Federal or State, but are exempt from all taxation now or hereafter imposed on the...

7 CFR 248.13 - FMNP income.

Science.gov (United States)

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false FMNP income. 248.13 Section 248.13 Agriculture... FMNP income. Program income means gross income the State agency earns from grant supported activities... property. The State agency shall retain Program income earned during the agreement period and use it for...

40 CFR 73.13 - Procedures for submittals.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Procedures for submittals. 73.13 Section 73.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE ALLOWANCE SYSTEM Allowance Allocations § 73.13 Procedures for submittals. (a...

Combined 18F-NaF and 18F-FDG PET/CT in the Evaluation of Sarcoma Patients.

Science.gov (United States)

Jackson, Tatianie; Mosci, Camila; von Eyben, Rie; Mittra, Erik; Ganjoo, Kristen; Biswal, Sandip; Gambhir, Sanjiv Sam; Iagaru, Andrei

2015-09-01

The combined administration of F-NaF and F-FDG in a single PET/CT scan has the potential to improve patient convenience and cancer detection. Here we report the use of this approach for patients with sarcomas. This is a retrospective review of 21 patients (12 men, 9 women; age, 19-66 years) with biopsy-proven sarcomas who had separate F-NaF PET/CT, F-FDG PET/CT, and combined F-NaF/F-FDG PET/CT scans for evaluation of malignancy. Two board-certified nuclear medicine physicians and 1 board-certified musculoskeletal radiologist were randomly assigned to review the scans. Results were analyzed for sensitivity and specificity, using linear regression and receiver operating characteristics. A total of 13 patients had metastatic disease on F-NaF PET/CT, F-FDG PET/CT, and combined F-NaF/F-FDG PET/CT. Skeletal disease was more extensive on the F-NaF PET/CT scan than on the F-FDG PET/CT in 3 patients, whereas in 1 patient, F-FDG PET/CT showed skeletal disease and the F-NaF PET/CT was negative. Extraskeletal lesions were detected on both F-FDG and combined F-NaF/F-FDG PET/CT in 20 patients, with 1 discordant finding in the lung. The combined F-NaF/F-FDG PET/CT scan allows for accurate evaluation of sarcoma patients. Further evaluation of this proposed imaging modality is warranted to identify the most suitable clinical scenarios, including initial treatment strategy and evaluation of response to therapy.

34 CFR 81.13 - Mediation.

Science.gov (United States)

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Mediation. 81.13 Section 81.13 Education Office of the... Mediation. (a) Voluntary mediation is available for proceedings that are pending before the OALJ. (b) A... mediation by filing a motion with the ALJ assigned to the case. The OALJ arranges for a mediator if the...

13 CFR 120.191 - The contents of a business loan application.

Science.gov (United States)

2010-01-01

..., among other things, a description of the history and nature of the business, the amount and purpose of... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false The contents of a business loan application. 120.191 Section 120.191 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS...

24 CFR 13.4 - Reports.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Reports. 13.4 Section 13.4 Housing... PENALTY MAIL IN THE LOCATION AND RECOVERY OF MISSING CHILDREN § 13.4 Reports. HUD shall compile and submit... report on its experience in implementing S. 1195 Official Mail Use in the Location and Recovery of...

7 CFR 1777.13 - Project priority.

Science.gov (United States)

2010-01-01

... joint financing committed to the proposed project is: (i) Twenty percent or more private, local, or.... (See definition in § 1777.4). The proposed project will provide water and/or waste disposal services to... 7 Agriculture 12 2010-01-01 2010-01-01 false Project priority. 1777.13 Section 1777.13 Agriculture...

14 CFR Appendix F to Part 135 - Airplane Flight Recorder Specification

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Airplane Flight Recorder Specification F.... F Appendix F to Part 135—Airplane Flight Recorder Specification The recorded values must meet the....125 0.004g 6. Pitch Attitude ±75% ±2° 1 or 0.25 for airplanes operated under § 135.152(j) 0.5° A...

NCBI nr-aa BLAST: CBRC-LAFR-01-0224 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-LAFR-01-0224 ref|ZP_01753627.1| cytochrome c-type biogenesis protein CcmF [Rose...obacter sp. SK209-2-6] gb|EBA17994.1| cytochrome c-type biogenesis protein CcmF [Roseobacter sp. SK209-2-6] ZP_01753627.1 0.033 24% ...

6 CFR 13.5 - Review by the Reviewing Official.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Review by the Reviewing Official. 13.5 Section 13.5 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.5 Review by the Reviewing Official. (a) If, based on the report of the Investigating Official...

6 CFR 13.10 - Default upon failure to answer.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Default upon failure to answer. 13.10 Section 13.10 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.10 Default upon failure to answer. (a) If the Defendant does not answer within the time...

7 CFR 318.13-25 - Sweet potatoes from Hawaii.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Sweet potatoes from Hawaii. 318.13-25 Section 318.13... INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE STATE OF HAWAII AND TERRITORIES QUARANTINE NOTICES Regulated Articles From Hawaii and the Territories § 318.13-25 Sweet potatoes from Hawaii. (a) Sweet potatoes may be...

30 CFR 780.13 - Operation plan: Blasting.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Operation plan: Blasting. 780.13 Section 780.13... SURFACE MINING PERMIT APPLICATIONS-MINIMUM REQUIREMENTS FOR RECLAMATION AND OPERATION PLAN § 780.13 Operation plan: Blasting. (a) Blasting plan. Each application shall contain a blasting plan for the proposed...

12 CFR 1408.13 - Contracting for collection services.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Contracting for collection services. 1408.13 Section 1408.13 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION COLLECTION OF CLAIMS OWED THE UNITED STATES Administrative Collection of Claims § 1408.13 Contracting for collection services. The...

7 CFR 318.13-23 - Cut flowers from Hawaii.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Cut flowers from Hawaii. 318.13-23 Section 318.13-23... SERVICE, DEPARTMENT OF AGRICULTURE STATE OF HAWAII AND TERRITORIES QUARANTINE NOTICES Regulated Articles From Hawaii and the Territories § 318.13-23 Cut flowers from Hawaii. (a) Except for cut blooms and leis...

36 CFR 13.1206 - Wildlife distance conditions.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Wildlife distance conditions. 13.1206 Section 13.1206 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... Provisions § 13.1206 Wildlife distance conditions. (a) Approaching a bear or any large mammal within 50 yards...

36 CFR 13.604 - Wildlife distance conditions.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Wildlife distance conditions. 13.604 Section 13.604 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE... § 13.604 Wildlife distance conditions. (a) Approaching a bear or any large mammal within 50 yards is...

A novel process for recycling and resynthesizing LiNi1/3Co1/3Mn1/3O2 from the cathode scraps intended for lithium-ion batteries

International Nuclear Information System (INIS)

Zhang, Xihua; Xie, Yongbing; Cao, Hongbin; Nawaz, Faheem; Zhang, Yi

2014-01-01

Highlights: • A simple process to recycle cathode scraps intended for lithium-ion batteries. • Complete separation of the cathode material from the aluminum foil is achieved. • The recovered aluminum foil is highly pure. • LiNi 1/3 Co 1/3 Mn 1/3 O 2 is directly resynthesized from the separated cathode material. - Abstract: To solve the recycling challenge for aqueous binder based lithium-ion batteries (LIBs), a novel process for recycling and resynthesizing LiNi 1/3 Co 1/3 Mn 1/3 O 2 from the cathode scraps generated during manufacturing process is proposed in this study. Trifluoroacetic acid (TFA) is employed to separate the cathode material from the aluminum foil. The effects of TFA concentration, liquid/solid (L/S) ratio, reaction temperature and time on the separation efficiencies of the cathode material and aluminum foil are investigated systematically. The cathode material can be separated completely under the optimal experimental condition of 15 vol.% TFA solution, L/S ratio of 8.0 mL g −1 , reacting at 40 °C for 180 min along with appropriate agitation. LiNi 1/3 Co 1/3 Mn 1/3 O 2 is successfully resynthesized from the separated cathode material by solid state reaction method. Several kinds of characterizations are performed to verify the typical properties of the resynthesized LiNi 1/3 Co 1/3 Mn 1/3 O 2 powder. Electrochemical tests show that the initial charge and discharge capacities of the resynthesized LiNi 1/3 Co 1/3 Mn 1/3 O 2 are 201 mAh g −1 and 155.4 mAh g −1 (2.8–4.5 V, 0.1 C), respectively. The discharge capacity remains at 129 mAh g −1 even after 30 cycles with a capacity retention ratio of 83.01%

75 FR 35611 - Airworthiness Directives; McDonnell Douglas Corporation Model DC-10-10, DC-10-10F, and MD-10-10F...

Science.gov (United States)

2010-06-23

... Airworthiness Directives; McDonnell Douglas Corporation Model DC- 10-10, DC-10-10F, and MD-10-10F Airplanes... certain McDonnell Douglas Model DC-10-10, DC-10-10F, and MD-10-10F airplanes. That NPRM was published in... amends Sec. 39.13 by adding the following new AD: 2010-13-06 McDonnell Douglas Corporation: Amendment 39...

13 CFR 134.709 - When will a Judge dismiss an appeal?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false When will a Judge dismiss an appeal? 134.709 Section 134.709 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE OFFICE OF HEARINGS AND APPEALS Rules of Practice for Appeals From Women...

15 CFR 19.13 - How will Commerce entities use administrative wage garnishment to collect a Commerce debt from a...

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false How will Commerce entities use administrative wage garnishment to collect a Commerce debt from a debtor's wages? 19.13 Section 19.13 Commerce and Foreign Trade Office of the Secretary of Commerce COMMERCE DEBT COLLECTION Procedures To Collect...

5 CFR 1203.13 - Filing pleadings.

Science.gov (United States)

2010-01-01

... delivery, by facsimile, or by e-filing in accordance with § 1201.14 of this chapter. If the document was... submitted by e-filing, it is considered to have been filed on the date of electronic submission. (e... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Filing pleadings. 1203.13 Section 1203.13...

47 CFR 15.13 - Incidental radiators.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 1 2010-10-01 2010-10-01 false Incidental radiators. 15.13 Section 15.13 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES General § 15.13 Incidental radiators. Manufacturers of these devices shall employ good engineering practices to minimize the risk of...

6 CFR 13.44 - Right to administrative offset.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Right to administrative offset. 13.44 Section 13.44 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.44 Right to administrative offset. The amount of any penalty or assessment that has become...

Analysis of porcine MUC4 gene as a candidate gene for prolificacy QTL on SSC13 in an Iberian × Meishan F2 population

Directory of Open Access Journals (Sweden)

Balcells Ingrid

2011-10-01

Full Text Available Abstract Background Reproductive traits, such as prolificacy, are of great interest to the pig industry. Better understanding of their genetic architecture should help to increase the efficiency of pig productivity through the implementation of marker assisted selection (MAS programmes. Results The Mucin 4 (MUC4 gene has been evaluated as a candidate gene for a prolificacy QTL described in an Iberian × Meishan (Ib × Me F2 intercross. For association analyses, two previously described SNPs (DQ124298:g.243A>G and DQ124298:g.344A>G were genotyped in 347 pigs from the Ib × Me population. QTL for the number of piglets born alive (NBA and for the total number of piglets born (TNB were confirmed on SSC13 at positions 44 cM and 51 cM, respectively. The MUC4 gene was successfully located within the confidence intervals of both QTL. Only DQ124298:g.344A>G MUC4 polymorphism was significantly associated with both NBA and TNB (P-value MUC4 expression level was determined in F2 sows displaying extreme phenotypes for the number of embryos (NE at 30-32 days of gestation. Differences in the uterine expression of MUC4 were found between high (NE ≥ 13 and low (NE ≤ 11 prolificacy sows. Overall, MUC4 expression in high prolificacy sows was almost two-fold increased compared with low prolificacy sows. Conclusions Our data suggest that MUC4 could play an important role in the establishment of an optimal uterine environment that would increase embryonic survival during pig gestation.

7 CFR 318.13-17 - Regulated articles from Guam.

Science.gov (United States)

2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false Regulated articles from Guam. 318.13-17 Section 318.13... Articles From Hawaii and the Territories § 318.13-17 Regulated articles from Guam. (a)(1) Regulated articles, other than soil, may be moved from Guam into or through any other State only if they meet the...

The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of α2δ subunits is key to trafficking voltage-gated Ca2+ channels

Science.gov (United States)

Cantí, C.; Nieto-Rostro, M.; Foucault, I.; Heblich, F.; Wratten, J.; Richards, M. W.; Hendrich, J.; Douglas, L.; Page, K. M.; Davies, A.; Dolphin, A. C.

2005-01-01

All auxiliary α2δ subunits of voltage-gated Ca2+ (CaV) channels contain an extracellular Von Willebrand factor-A (VWA) domain that, in α2δ-1 and -2, has a perfect metal-ion-dependent adhesion site (MIDAS). Modeling of the α2δ-2 VWA domain shows it to be highly likely to bind a divalent cation. Mutating the three key MIDAS residues responsible for divalent cation binding resulted in a MIDAS mutant α2δ-2 subunit that was still processed and trafficked normally when it was expressed alone. However, unlike WT α2δ-2, the MIDAS mutant α2δ-2 subunit did not enhance and, in some cases, further diminished CaV1.2, -2.1, and -2.2 currents coexpressed with β1b by using either Ba2+ or Na+ as a permeant ion. Furthermore, expression of the MIDAS mutant α2δ-2 reduced surface expression and strongly increased the perinuclear retention of CaVα1 subunits at the earliest time at which expression was observed in both Cos-7 and NG108–15 cells. Despite the presence of endogenous α2δ subunits, heterologous expression of α2δ-2 in differentiated NG108–15 cells further enhanced the endogenous high-threshold Ca2+ currents, whereas this enhancement was prevented by the MIDAS mutations. Our results indicate that α2δ subunits normally interact with the CaVα1 subunit early in their maturation, before the appearance of functional plasma membrane channels, and an intact MIDAS motif in the α2δ subunit is required to promote trafficking of the α1 subunit to the plasma membrane by an integrin-like switch. This finding provides evidence for a primary role of a VWA domain in intracellular trafficking of a multimeric complex, in contrast to the more usual roles in binding extracellular ligands in other exofacial VWA domains. PMID:16061813

Low carbohydrate diet before 18F-FDG tumor imaging contributes to reduce myocardial 18F-FDG uptake

International Nuclear Information System (INIS)

Miao Weibing; Chen Shaoming; Zheng Shan; Wu Jing; Peng Jiequan; Jiang Zhihong

2014-01-01

Objective: To evaluate whether low carbohydrate diet before 18 F-FDG tumor imaging could reduce myocardial 18 F-FDG uptake. Methods: From April 2011 to January 2012, 70 patients were enrolled in this study.They were randomly divided into control group (34 cases) and test group (36 cases). Patients in control group were on regular diet, while those in test group had low carbohydrate diet in the evening before imaging. Blood samples were taken before injection of 18 F-FDG for the measurement of serum glucose, free fatty acid,insulin and ketone body. Whole body 18 F-FDG tomography was performed with dual-head coincidence SPECT. The myocardial uptake of FDG was assessed visually and scored as 0 for no uptake, 1 for uptake lower than liver, 2 for uptake similar to liver, 3 for uptake higher than liver, and 4 for remarkable uptake.The ratio of myocardium to liver (H/L) was calculated. Two-sample t test, Wilcoxon rank sum test and linear correlation analysis were performed. Results: The myocardial uptake in test group was significantly lower than that in control group with H/L ratios of 0.94±0.57 and 1.50±1.04, respectively (t=-2.75, P<0.05). The concentrations of serum free fatty acid and ketone body in test group were significantly higher than those in control group: (0.671±0.229) mmol/L vs (0.547±0.207) mmol/L and (0.88±0.60) mmol/L vs (0.57±0.32) mmol/L, t=2.38 and 2.67, both P<0.05. The concentrations of glucose and insulin were (5.28±1.06) mmol/L and (35.16±33.70) pmol/L in test group, which showed no significant difference with those in control group ((5.19±0.78) mmol/L and (41.64±35.13) pmol/L, t=0.39 and-0.79, both P>0.05). A negative correlation was found between the myocardial uptake of 18 F-FDG and serum free fatty acid/ketone body concentration (r=-0.40, -0.33, both P<0.01), respectively. There was no correlation between the myocardial uptake of 18 F-FDG and glucose/insulin (r=-0.02, 0.13, both P>0.05), respectively. Conclusion: Low carbohydrate

49 CFR 450.13 - Granting of delegation.

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2010-10-01

... 49 Transportation 6 2010-10-01 2010-10-01 false Granting of delegation. 450.13 Section 450.13... SECURITY SAFETY APPROVAL OF CARGO CONTAINERS GENERAL Procedure for Delegation to Approval Authorities § 450.13 Granting of delegation. (a) The Chief, Office of Operating and Environmental Standards (CG-522), U...

50 CFR 100.13 - Board/agency relationships.

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2010-10-01

... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Board/agency relationships. 100.13 Section 100.13 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR... Structure § 100.13 Board/agency relationships. (a) General. (1) The Board, in making decisions or...

29 CFR Appendix F to Part 825 - [Reserved

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2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false [Reserved] F Appendix F to Part 825 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR OTHER LAWS THE FAMILY AND MEDICAL LEAVE ACT OF 1993 Appendix F to Part 825 [Reserved] ...

40 CFR 247.13 - Transportation products.

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2010-07-01

... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Transportation products. 247.13 Section 247.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Transportation products. (a) Traffic barricades and traffic cones used in controlling or restricting vehicular...

32 CFR 732.13 - Sources of care.

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2010-07-01

... 32 National Defense 5 2010-07-01 2010-07-01 false Sources of care. 732.13 Section 732.13 National... CARE Medical and Dental Care From Nonnaval Sources § 732.13 Sources of care. (a) Initial application. If a member requires maternity, medical, or dental care and naval facilities are unavailable, make...

29 CFR 779.386 - Restaurants may qualify as exempt 13(a)(2) establishments.

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2010-07-01

... 29 Labor 3 2010-07-01 2010-07-01 false Restaurants may qualify as exempt 13(a)(2) establishments... Service Establishments Restaurants and Establishments Providing Food and Beverage Service § 779.386 Restaurants may qualify as exempt 13(a)(2) establishments. (a) A restaurant may qualify as an exempt retail or...

6 CFR 13.16 - Disqualification of Reviewing Official or ALJ.

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2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Disqualification of Reviewing Official or ALJ. 13.16 Section 13.16 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.16 Disqualification of Reviewing Official or ALJ. (a) A Reviewing...

13 CFR 124.509 - What are non-8(a) business activity targets?

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2010-01-01

... non-8(a) business activity targets. These include requiring the Participant to obtain management..., business development, financing, marketing, accounting, or proposal preparation. (5) SBA may initiate... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false What are non-8(a) business...

Experiment data report for semiscale Mod-1 Tests S-01-4 and S-01-4A (isothermal blowdown with core resistance simulator)

International Nuclear Information System (INIS)

Zender, S.N.; Jensen, M.F.; Sackett, K.E.

1975-03-01

Recorded test data are presented for Tests S-01-4 and S-01-4A of the semiscale Mod-1 isothermal blowdown test series. These tests are among several semiscale Mod-1 experiments which are counterparts of the planned Loss-of-Fluid Test (LOFT) nonnuclear experiments. System hardware is representative of LOFT design based on volumetric scaling methods, and initial conditions duplicate those identified for the LOFT nonnuclear tests. Tests S-01-4 and S-01-4A employed an intact loop resistance that was similar to that of Test S-01-3 and low relative to that of Test S-01-2. An orificed structure was used in the pressure vessel to simulate the LOFT core simulator. The tests were initiated at initial isothermal conditions of about 2250 psig and 540 0 F by a simulated offset shear of the cold-leg broken-loop piping. During system depressurization, coolant was injected into the cold leg of the intact loop to provide data on the effects of emergency core cooling on system response. Following the blowdown portion of Test S-01-4, coolant spray was introduced into the pressure suppression tank to determine the response of the pressure suppression system. The uninterpreted data are presented. The data, presented in the form of graphs in engineering units, have been analyzed only to the extent necessary to assure that they are reasonable and consistent. (U.S.)

13 CFR 147.655 - Individual.

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2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Individual. 147.655 Section 147.655 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Definitions § 147.655 Individual. Individual means a natural person. ...

13 CFR 113.540 - Advertising.

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2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Advertising. 113.540 Section 113.540 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NONDISCRIMINATION IN FINANCIAL... Advertising. A recipient shall not in any advertising related to employment indicate preference, limitation...

45 CFR 1340.13 - Approval of applications.

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2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Approval of applications. 1340.13 Section 1340.13... NEGLECT PREVENTION AND TREATMENT PROGRAM CHILD ABUSE AND NEGLECT PREVENTION AND TREATMENT Grants to States § 1340.13 Approval of applications. (a) The Commissioner shall approve an application for an award for...

16 CFR 305.13 - Labeling for ceiling fans.

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2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Labeling for ceiling fans. 305.13 Section... Disclosures § 305.13 Labeling for ceiling fans. (a) Ceiling fans—(1) Content. Any covered product that is a ceiling fan shall be labeled clearly and conspicuously on the principal display panel with the following...

AR-13, a Celecoxib Derivative, Directly Kills Francisella In Vitro and Aids Clearance and Mouse Survival In Vivo

Directory of Open Access Journals (Sweden)

Ky V. Hoang

2017-09-01

Full Text Available Francisella tularensis (F. tularensis is the causative agent of tularemia and is classified as a Tier 1 select agent. No licensed vaccine is currently available in the United States and treatment of tularemia is confined to few antibiotics. In this study, we demonstrate that AR-13, a derivative of the cyclooxygenase-2 inhibitor celecoxib, exhibits direct in vitro bactericidal killing activity against Francisella including a type A strain of F. tularensis (SchuS4 and the live vaccine strain (LVS, as well as toward the intracellular proliferation of LVS in macrophages, without causing significant host cell toxicity. Identification of an AR-13-resistant isolate indicates that this compound has an intracellular target(s and that efflux pumps can mediate AR-13 resistance. In the mouse model of tularemia, AR-13 treatment protected 50% of the mice from lethal LVS infection and prolonged survival time from a lethal dose of F. tularensis SchuS4. Combination of AR-13 with a sub-optimal dose of gentamicin protected 60% of F. tularensis SchuS4-infected mice from death. Taken together, these data support the translational potential of AR-13 as a lead compound for the further development of new anti-Francisella agents.

15 CFR 325.13 - Nonadmissibility in evidence.

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2010-01-01

... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nonadmissibility in evidence. 325.13 Section 325.13 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) INTERNATIONAL TRADE ADMINISTRATION, DEPARTMENT OF COMMERCE MISCELLANEOUS REGULATIONS EXPORT TRADE CERTIFICATES...

7 CFR 3402.13 - National need narrative.

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2010-01-01

... 7 Agriculture 15 2010-01-01 2010-01-01 false National need narrative. 3402.13 Section 3402.13... narrative. HEP will determine the composition of the narrative for each competition, including page limits.... Detailed instructions for preparing the narrative will be published in the solicitation. ...

40 CFR 191.13 - Containment requirements.

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2010-07-01

... requirements. (a) Disposal systems for spent nuclear fuel or high-level or transuranic radioactive wastes shall... 40 Protection of Environment 24 2010-07-01 2010-07-01 false Containment requirements. 191.13 Section 191.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) RADIATION PROTECTION...

7 CFR 319.8-13 - From Northwest Mexico.

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2010-01-01

... 7 Agriculture 5 2010-01-01 2010-01-01 false From Northwest Mexico. 319.8-13 Section 319.8-13... for the Entry of Cotton and Covers from Mexico § 319.8-13 From Northwest Mexico. Contingent upon continued freedom of Northwest Mexico and of the West Coast of Mexico from infestations of the pink bollworm...

40 CFR 273.13 - Waste management.

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2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Waste management. 273.13 Section 273...) STANDARDS FOR UNIVERSAL WASTE MANAGEMENT Standards for Small Quantity Handlers of Universal Waste § 273.13 Waste management. (a) Universal waste batteries. A small quantity handler of universal waste must manage...

Mild hydrothermal crystal growth of new uranium(IV) fluorides, Na{sub 3.13}Mg{sub 1.43}U{sub 6}F{sub 30} and Na{sub 2.50}Mn{sub 1.75}U{sub 6}F{sub 30}: Structures, optical and magnetic properties

Energy Technology Data Exchange (ETDEWEB)

Yeon, Jeongho; Smith, Mark D. [Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208 (United States); Tapp, Joshua; Möller, Angela [Department of Chemistry and Texas Center for Superconductivity, University of Houston, Houston, TX 77204 (United States); Loye, Hans-Conrad zur, E-mail: zurloye@mailbox.sc.edu [Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208 (United States)

2016-04-15

Two new uranium(IV) fluorides, Na{sub 3.13}Mg{sub 1.43}U{sub 6}F{sub 30} (1) and Na{sub 2.50}Mn{sub 1.75}U{sub 6}F{sub 30} (2), were synthesized through an in situ mild hydrothermal route, and were structurally characterized by single crystal X-ray diffraction. The compounds exhibit complex crystal structures composed of corner- or edge-shared UF{sub 9} and MF{sub 6} (M=Mg, Mn) polyhedra, forming hexagonal channels in the three-dimensional framework, in which ordered or disordered divalent metal and sodium atoms reside. The large hexagonal voids contain the nearly regular M(II)F{sub 6} octahedra and sodium ions, whereas the small hexagonal cavities include M(II) and sodium ions on a mixed-occupied site. Magnetic susceptibility measurements yielded effective magnetic moments of 8.36 and 11.6 µ{sub B} for 1 and 2, respectively, confirming the presence and oxidation states of U(IV) and Mn(II). The large negative Weiss constants indicate the spin gap between a triplet and a singlet state in the U(IV). Magnetization data as a function of applied fields revealed that 2 exhibits paramagnetic behavior due to the nonmagnetic singlet ground state of U(IV) at low temperature. UV–vis diffuse reflectance and X-ray photoelectron spectroscopy data were also analyzed. - Graphical abstract: Two new quaternary U(IV) fluorides, Na{sub 3.13}Mg{sub 1.43}U{sub 6}F{sub 30} and Na{sub 2.50}Mn{sub 1.75}U{sub 6}F{sub 30}, were crystallized via an in situ reduction step of U(VI) to U(IV) under mild hydrothermal conditions. The compounds show complex crystal structures based on the 3-D building block of U{sub 6}F{sub 30}. Magnetic property measurements revealed that the U(IV) exhibits a nonmagnetic singlet ground state at low temperature with a spin gap. - Highlights: • Na{sub 3.13}Mg{sub 1.43}U{sub 6}F{sub 30} and Na{sub 2.50}Mn{sub 1.75}U{sub 6}F{sub 30} have been synthesized and characterized. • The U(IV) fluorides exhibit complex three-dimensional crystal structures. • The

9 CFR 316.13 - Marking of outside containers.

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2010-01-01

... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Marking of outside containers. 316.13... INSPECTION AND CERTIFICATION MARKING PRODUCTS AND THEIR CONTAINERS § 316.13 Marking of outside containers. (a... domestic commerce is moved from an official establishment, the outside container shall bear an official...

10 CFR 436.13 - Presuming cost-effectiveness results.

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2010-01-01

... 10 Energy 3 2010-01-01 2010-01-01 false Presuming cost-effectiveness results. 436.13 Section 436... Methodology and Procedures for Life Cycle Cost Analyses § 436.13 Presuming cost-effectiveness results. (a) If the investment and other costs for an energy or water conservation measure considered for retrofit to...

7 CFR 632.13 - Eligible lands and water.

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2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Eligible lands and water. 632.13 Section 632.13... lands and water. Lands and water eligible for reclamation are those that were mined for coal or were... lands and water are not eligible if: (a) There is continuing reclamation responsibility on the part of a...

32 CFR 855.13 - Civil fly-ins.

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2010-07-01

... 32 National Defense 6 2010-07-01 2010-07-01 false Civil fly-ins. 855.13 Section 855.13 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE AIRCRAFT CIVIL AIRCRAFT USE OF UNITED STATES AIR FORCE AIRFIELDS Civil Aircraft Landing Permits § 855.13 Civil fly-ins. (a) Civil...

46 CFR 160.066-13 - Technical tests.

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2010-10-01

... 46 Shipping 6 2010-10-01 2010-10-01 false Technical tests. 160.066-13 Section 160.066-13 Shipping....066-13 Technical tests. (a) The following conditions apply to technical tests as described in this... signals are protected by sealed packaging, then the conditioning for the technical tests must be conducted...

13 CFR 113.450 - Athletics.

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2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Athletics. 113.450 Section 113.450 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NONDISCRIMINATION IN FINANCIAL ASSISTANCE... female teams if a recipient operates or sponsors separate teams will not constitute noncompliance with...

36 CFR 9.13 - Performance bond.

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2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Performance bond. 9.13... MINERALS MANAGEMENT Mining and Mining Claims § 9.13 Performance bond. (a) Upon approval of a plan of operations the operator shall be required to file a suitable performance bond with satisfactory surety...

40 CFR 407.13 - [Reserved

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2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true [Reserved] 407.13 Section 407.13 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS CANNED AND PRESERVED FRUITS AND VEGETABLES PROCESSING POINT SOURCE CATEGORY Apple Juice Subcategory § 407...

36 CFR 13.1236 - Bear orientation.

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2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Bear orientation. 13.1236 Section 13.1236 Parks, Forests, and Public Property NATIONAL PARK SERVICE, DEPARTMENT OF THE INTERIOR... Developed Area § 13.1236 Bear orientation. All persons visiting the BCDA must receive an NPS-approved Bear...

49 CFR 95.13 - Antitrust laws.

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2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Antitrust laws. 95.13 Section 95.13 Transportation Office of the Secretary of Transportation ADVISORY COMMITTEES § 95.13 Antitrust laws. The activities of advisory committees are subject to the antitrust laws and committee members are not immune from prosecution...

29 CFR 18.13 - Discovery methods.

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2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Discovery methods. 18.13 Section 18.13 Labor Office of the... ADMINISTRATIVE LAW JUDGES General § 18.13 Discovery methods. Parties may obtain discovery by one or more of the following methods: Depositions upon oral examination or written questions; written interrogatories...

44 CFR 13.44 - Termination for convenience.

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2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Termination for convenience. 13.44 Section 13.44 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY... § 13.44 Termination for convenience. Except as provided in § 13.43 awards may be terminated in whole or...

13 CFR 120.350 - Policy.

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2010-01-01

... a qualified employee trust (“ESOP”) to: (a) Help finance the growth of its employer's small business... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Policy. 120.350 Section 120.350 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Qualified...

13 CFR 120.343 - Collateral.

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2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Collateral. 120.343 Section 120.343 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Special Purpose Loans Export Working Capital Program (ewcp) § 120.343 Collateral. A Borrower must give SBA a first security...

U.S. EPA, Pesticide Product Label, FOOD PLANT FOGGING INSECTICIDE, 01/30/1990

Science.gov (United States)

2011-04-14

... w.lter. food, 01" fet:,1 hy ')lur.J,:!C 01 ,li· ••• u"> •• I. ... (his proJuct c. .• Z",.. IfitJ~f'!f.1.~. I)n thi') label" •• o 6""(l'r .' ... IJlIIC'i ,111 ri'1lks of J\\t~ ')lo.SI~I~ or'. ...

34 CFR 606.13 - How many applications for a development grant may an institution submit?

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2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false How many applications for a development grant may an institution submit? 606.13 Section 606.13 Education Regulations of the Offices of the Department of Education... INSTITUTIONS PROGRAM How Does an Institution Apply for a Grant? § 606.13 How many applications for a...

34 CFR 607.13 - How many applications for a development grant may an institution submit?

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2010-07-01

... 34 Education 3 2010-07-01 2010-07-01 false How many applications for a development grant may an institution submit? 607.13 Section 607.13 Education Regulations of the Offices of the Department of Education... Does an Institution Apply for a Grant? § 607.13 How many applications for a development grant may an...

12 CFR 563g.13 - Public disclosure and confidential treatment.

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2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Public disclosure and confidential treatment. 563g.13 Section 563g.13 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITIES OFFERINGS § 563g.13 Public disclosure and confidential treatment. (a) Any offering circular...

15 CFR 14.13 - Debarment and suspension.

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2010-01-01

... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Debarment and suspension. 14.13 Section 14.13 Commerce and Foreign Trade Office of the Secretary of Commerce UNIFORM ADMINISTRATIVE... shall comply with the nonprocurement debarment and suspension common rule implementing E.O.s 12549 and...

12 CFR 905.13 - Office of Supervision.

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2010-01-01

... market, credit and operational risks; (3) Analyzing the financial performance of the Banks; (4) Preparing... Loan Mortgage Corporation (Freddie Mac) purchases and guarantees; (5) Analyzing the Banks' performance... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Office of Supervision. 905.13 Section 905.13...

13 CFR 113.510 - Recruitment.

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2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Recruitment. 113.510 Section 113... Recruitment. (a) Nondiscriminatory recruitment and hiring. A recipient shall not discriminate on the basis of sex in the recruitment and hiring of employees. Where a recipient has been found to be presently...

42 CFR 409.13 - Drugs and biologicals.

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2010-10-01

... 42 Public Health 2 2010-10-01 2010-10-01 false Drugs and biologicals. 409.13 Section 409.13 Public... § 409.13 Drugs and biologicals. (a) Except as specified in paragraph (b) of this section, Medicare pays for drugs and biologicals as inpatient hospital or inpatient CAH services only if— (1) They represent...

32 CFR 635.13 - Amendment of records.

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2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Amendment of records. 635.13 Section 635.13 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) LAW ENFORCEMENT AND CRIMINAL INVESTIGATIONS LAW ENFORCEMENT REPORTING Release of Information § 635.13 Amendment of records. (a) Policy. An amendment of records is...

32 CFR 728.13 - Application for care.

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2010-07-01

... Duty § 728.13 Application for care. Possession of an ID card (a green colored DD 2 (with letter suffix... 32 National Defense 5 2010-07-01 2010-07-01 false Application for care. 728.13 Section 728.13 National Defense Department of Defense (Continued) DEPARTMENT OF THE NAVY PERSONNEL MEDICAL AND DENTAL CARE...

NCBI nr-aa BLAST: CBRC-CJAC-01-0074 [SEVENS

Lifescience Database Archive (English)

Full Text Available CBRC-CJAC-01-0074 ref|NP_336427.1| PPE family protein [Mycobacterium tuberculosis C...DC1551] ref|YP_001287884.1| PPE family protein [Mycobacterium tuberculosis F11] gb|AAK46241.1| PPE family protein [Mycobacterium tube...rculosis CDC1551] gb|ABR06282.1| PPE family protein [Mycobacterium tuberculosis F11] NP_336427.1 0.001 26% ...

13 CFR 143.32 - Equipment.

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2010-01-01

... awarding agency. (d) Management requirements. Procedures for managing equipment (including replacement... return. (e) Disposition. When original or replacement equipment acquired under a grant or subgrant is no... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Equipment. 143.32 Section 143.32...

13 CFR 302.19 - Indemnification.

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2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Indemnification. 302.19 Section 302.19 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE... permitted by law, a Recipient shall indemnify and hold EDA harmless from any liability that EDA may incur...

In situ ToF-SIMS monitoring of SOFC cathodes - A case study of La0.74Sr0.17Mn1.01O2.9 model electrodes

Science.gov (United States)

Rohnke, M.; Schaepe, K.; Bachmann, A.-K.; Laenger, M.; Janek, J.

2017-11-01

The modelling of electrode kinetics of solid oxide fuel cells is challenging, as the electrodes can change their composition and microstructure during operation at high temperature. Here we present results from in situ studies, applying time of flight secondary ion mass spectrometry (ToF-SIMS) to investigate compositional surface changes of lanthanum strontium manganate (LSM) model electrodes. Geometrically well-defined LSM electrodes with the composition La0.74Sr0.17Mn1.01O2.9 were deposited as thin films on yttria stabilised zirconia (YSZ) single crystals by pulsed laser deposition. As counter electrode, a porous platinum electrode was applied on the backside of the solid electrolyte. The electrochemical polarisation experiments were carried out inside the ToF-SIMS analysis chamber at 430 °C, and the ToF-SIMS measurements were performed - in contrast to former work - for the first time during electrical polarisation at elevated temperatures. By applying either a cathodic or anodic potential to the LSM cathode, enrichment or depletion of the different metallic constituents on both, the LSM and free YSZ surface, and within the LSM near surface region, were observed. After polarisation, the system relaxes towards the thermodynamic equilibrium state. Already after the first heat treatment, diffusion of manganese and strontium from the LSM electrode onto the free YSZ surface is observed. The concomitant spreading of the three-phase boundary seems to be one reason for electrode activation after polarisation.

36 CFR 1004.13 - Obstructing traffic.

Science.gov (United States)

2010-07-01

... road, except as authorized by the Executive Director, or in the event of an accident or other condition... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Obstructing traffic. 1004.13 Section 1004.13 Parks, Forests, and Public Property PRESIDIO TRUST VEHICLES AND TRAFFIC SAFETY § 1004.13...

[Primary study on fluro [ 19F] berberine derivative for human hepatocellular carcinoma targetting in vitro].

Science.gov (United States)

Zhang, Tong; Wu, Xiaoai; Cai, Huawei; Liang, Meng; Fan, Chengzhong

2017-04-01

[ 18 F]HX-01, a Fluorine-18 labeled berberine derivative, is a potential positron emission tomography (PET) tumor imaging agent, while [ 19 F]HX-01 is a nonradioactive reference substance with different energy state and has the same physical and chemical properties. In order to collect data for further study of [ 18 F]HX-01 PET imaging of hepatocellular carcinoma in vivo , this study compared the uptake of [ 19 F]HX-01 by human hepatocellular carcinoma and normal hepatocytes in vitro . The target compound, [ 19 F]HX-01, was synthesized in one step using berberrubine and 3-fluoropropyl 4-methylbenzenesulfonate. Cellular uptake and localization of [ 19 F]HX-01 were performed by a fluorescence microscope in human hepatocellular carcinoma HepG2, SMMC-7721 and human normal hepatocyte HL-7702. Cellular proliferation inhibition and cell cytotoxicity assay of the [ 19 F]HX-01 were conducted using cell counting kit-8 (CCK-8) on HepG2, SMMC-7721 and HL-7702 cells. Fluorescent microscopy showed that the combining ability of [ 19 F]HX-01 to the carcinoma SMMC-7721 and HepG2 was higher than that to the normal HL-7702. Cellular proliferation inhibition assay demonstrated that [ 19 F]HX-01 leaded to a dose-dependent inhibition on SMMC-7721, HepG2, and HL-7702 proliferation. Cell cytotoxicity assay presented that the cytotoxicity of [ 19 F]HX-01 to SMMC-7721 and HepG2 was obviously higher than that to HL-7702. This in vitro study showed that [ 19 F]HX-01 had a higher selectivity on human hepatocellular carcinoma cells (SMMC-7721, HepG2) but has less toxicity to normal hepatocytes (HL-7702). This could set up the idea that the radioactive reference substance [ 18 F]HX-01 may be worthy of further development as a potential molecular probe targeting human hepatocellular carcinoma using PET.

6 CFR 13.30 - The hearing and burden of proof.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false The hearing and burden of proof. 13.30 Section 13.30 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.30 The hearing and burden of proof. (a) The ALJ will conduct a hearing on the record in order...

46 CFR 252.13 - Contract.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Contract. 252.13 Section 252.13 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION REGULATIONS AFFECTING SUBSIDIZED VESSELS AND OPERATORS OPERATING... Contract. Upon approval by the Board of an application for ODS, the applicant and the United States may...

44 CFR 13.25 - Program income.

Science.gov (United States)

2010-10-01

... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Program income. 13.25 Section... LOCAL GOVERNMENTS Post-Award Requirements Financial Administration § 13.25 Program income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees...

21 CFR 1308.13 - Schedule III.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 9 2010-04-01 2010-04-01 false Schedule III. 1308.13 Section 1308.13 Food and... opposite it. (b) Stimulants. Unless specifically excepted or unless listed in another schedule, any... a stimulant effect on the central nervous sxstem, including its salts, isomers (whether optical...

24 CFR 290.13 - Negotiated sales.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Negotiated sales. 290.13 Section... DEVELOPMENT HUD-OWNED PROPERTIES DISPOSITION OF MULTIFAMILY PROJECTS AND SALE OF HUD-HELD MULTIFAMILY MORTGAGES Disposition of Multifamily Projects § 290.13 Negotiated sales. When HUD conducts a negotiated sale...

6 CFR 13.26 - Filing, form and service of papers.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Filing, form and service of papers. 13.26 Section 13.26 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.26 Filing, form and service of papers. (a) Filing and form. (1) Documents filed with...

6 CFR 13.3 - Basis for civil penalties and assessments.

Science.gov (United States)

2010-01-01

... 6 Domestic Security 1 2010-01-01 2010-01-01 false Basis for civil penalties and assessments. 13.3 Section 13.3 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.3 Basis for civil penalties and assessments. (a) Claims. (1) Except as provided in...

13 CFR 147.640 - Employee.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Employee. 147.640 Section 147.640... WORKPLACE (NONPROCUREMENT) Definitions § 147.640 Employee. (a) Employee means the employee of a recipient directly engaged in the performance of work under the award, including— (1) All direct charge employees; (2...

15 CFR 2008.13 - Systematic review guidelines.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Systematic review guidelines. 2008.13 Section 2008.13 Commerce and Foreign Trade Regulations Relating to Foreign Trade Agreements OFFICE OF THE UNITED STATES TRADE REPRESENTATIVE REGULATIONS TO IMPLEMENT E.O. 12065; OFFICE OF THE UNITED STATES TRADE...

Association Between Osteogenesis and Inflammation During the Progression of Calcified Plaque Evaluated by 18F-Fluoride and 18F-FDG.

Science.gov (United States)

Li, Xiang; Heber, Daniel; Cal-Gonzalez, Jacobo; Karanikas, Georgios; Mayerhoefer, Marius E; Rasul, Sazan; Beitzke, Dietrich; Zhang, Xiaoli; Agis, Hermine; Mitterhauser, Markus; Wadsak, Wolfgang; Beyer, Thomas; Loewe, Christian; Hacker, Marcus

2017-06-01

18 F-FDG is the most widely validated PET tracer for the evaluation of atherosclerotic inflammation. Recently, 18 F-NaF has also been considered a potential novel biomarker of osteogenesis in atherosclerosis. We aimed to analyze the association between inflammation and osteogenesis at different stages of atherosclerosis, as well as the interrelationship between these 2 processes during disease progression. Methods: Thirty-four myeloma patients underwent 18 F-NaF and 18 F-FDG PET/CT examinations. Lesions were divided into 3 groups (noncalcified, mildly calcified, and severely calcified lesions) on the basis of calcium density as measured in Hounsfield units by CT. Tissue-to-background ratios were determined from PET for both tracers. The association between inflammation and osteogenesis during atherosclerosis progression was evaluated in 19 patients who had at least 2 examinations with both tracers. Results: There were significant correlations between the maximum tissue-to-background ratios of the 2 tracers (Spearman r = 0.5 [ P < 0.01]; Pearson r = 0.4 [ P < 0.01]) in the 221 lesions at baseline. The highest uptake of both tracers was observed in noncalcified lesions, but without any correlation between the tracers (Pearson r = 0.06; P = 0.76). Compared with noncalcified plaques, mildly calcified plaques showed concordant significantly lower accumulation, with good correlation between the tracers (Pearson r = 0.7; P < 0.01). In addition, enhanced osteogenesis-derived 18 F-NaF uptake and regressive inflammation-derived 18 F-FDG uptake were observed in severely calcified lesions (Pearson r = 0.4; P < 0.01). During follow-up, increased calcium density and increased mean 18 F-NaF uptake were observed, whereas mean 18 F-FDG uptake decreased. Most noncalcified (86%) and mildly calcified (81%) lesions and 47% of severely calcified lesions had concordant development of both vascular inflammation and osteogenesis. Conclusion: The combination of 18 F-NaF PET imaging and 18 F

13 CFR 126.801 - How does one file a HUBZone status protest?

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How does one file a HUBZone status protest? 126.801 Section 126.801 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION HUBZONE PROGRAM Protests § 126.801 How does one file a HUBZone status protest? (a) General. The protest procedures...

Current and other data from fixed platforms as part of the International Decade of Ocean Exploration / International Ocean Studies / First Dynamic Response and Kinematics Experiment in the Drake Passage (IDOE/ISOS/FDRAKE) from 1979-01-13 to 1980-02-01 (NODC Accession 8700085)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Current and other data were collected from fixed platforms from 13 January 1979 to 01 February 1980. Data were collected by Oregon State University (OSU) as part of...

38 CFR 13.102 - Accountability of legal custodians.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Accountability of legal custodians. 13.102 Section 13.102 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VETERANS BENEFITS ADMINISTRATION, FIDUCIARY ACTIVITIES § 13.102 Accountability of legal custodians. (a...

38 CFR 13.103 - Investments by Federal fiduciaries.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Investments by Federal fiduciaries. 13.103 Section 13.103 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS VETERANS BENEFITS ADMINISTRATION, FIDUCIARY ACTIVITIES § 13.103 Investments by Federal fiduciaries. (a...

13 CFR 136.140 - Employment.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Employment. 136.140 Section 136....140 Employment. (a) No qualified individual with handicaps shall, on the basis of handicap, be subjected to discrimination in employment under any program, or activity conducted by the Agency. (b) The...

13 CFR 106.101 - Definitions.

Science.gov (United States)

2010-01-01

... legal consideration. (i) Non-Fee Based SBA-Sponsored Activity Record (Non-Fee Based Record) means a... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Definitions. 106.101 Section 106.101 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION COSPONSORSHIPS, FEE AND NON-FEE BASED...

49 CFR Appendix F to Part 240 - Medical Standards Guidelines

Science.gov (United States)

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Medical Standards Guidelines F Appendix F to Part 240 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD.... F Appendix F to Part 240—Medical Standards Guidelines (1) The purpose of this appendix is to provide...

36 CFR 294.13 - Petition process.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false Petition process. 294.13... State Petitions for Inventoried Roadless Area Management § 294.13 Petition process. (a) Review and consideration of petitions made pursuant to § 294.12 shall be accomplished as follows: (1) Review. The Secretary...

16 CFR 240.13 - Customer's and third party liability.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Customer's and third party liability. 240.13 Section 240.13 Commercial Practices FEDERAL TRADE COMMISSION GUIDES AND TRADE PRACTICE RULES GUIDES FOR ADVERTISING ALLOWANCES AND OTHER MERCHANDISING PAYMENTS AND SERVICES § 240.13 Customer's and third party...

13 CFR 113.310 - Recruitment.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Recruitment. 113.310 Section 113... Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 113.310 Recruitment. (a) Nondiscriminatory recruitment. A recipient to which §§ 113.300 through 113.310 apply shall not discriminate on the...

13 CFR 143.33 - Supplies.

Science.gov (United States)

2010-01-01

... residual inventory of unused supplies exceeding $5,000 in total aggregate fair market value upon... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Supplies. 143.33 Section 143.33..., and Subawards § 143.33 Supplies. (a) Title. Title to supplies acquired under a grant or subgrant will...

In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous (18)F-FDG-PET and Hyperpolarized (13)C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

DEFF Research Database (Denmark)

Gutte, Henrik; Hansen, Adam E; Larsen, Majbrit M E

2015-01-01

In this communication the mismatch between simultaneous (18)F-FDG-PET and a (13)C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that (18)F-FDG-PET may not always reflect the Warburg effect...

13 CFR 120.925 - Preferences.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Preferences. 120.925 Section 120.925 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Development Company... Preference. (See § 120.10 for a definition of Preference.) [61 FR 3235, Jan. 31, 1996, as amended at 68 FR...

13 CFR 113.405 - Housing.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Housing. 113.405 Section 113.405... Discrimination on the Basis of Sex in Education Programs Or Activities Prohibited § 113.405 Housing. (a... different fees or requirements, or offer different services or benefits related to housing, except as...

13 CFR 500.105 - Staff.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Staff. 500.105 Section 500.105... LOAN PROGRAM Board Procedures § 500.105 Staff. (a) Executive Director. The Executive Director of the... direction with respect to the administration of the Board's actions, directs the activities of the staff...

13 CFR 400.105 - Staff.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Staff. 400.105 Section 400.105... Board Procedures § 400.105 Staff. (a) Executive Director. The Executive Director of the Board advises... with respect to the administration of the Board's actions, directs the activities of the staff, and...

13 CFR 117.12 - Mediation.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Mediation. 117.12 Section 117.12... Mediation. (a) SBA shall, after ensuring that the complaint falls within the coverage of this Act and all... clearly within an exception, promptly refer the complaint to the Federal Mediation and Conciliation...

13 CFR 120.10 - Definitions.

Science.gov (United States)

2010-01-01

... Provider is an entity that contracts with a Lender or CDC to perform management, marketing, legal or other... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Definitions. 120.10 Section 120.10 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS Definitions § 120.10...

23 CFR 658.13 - Length.

Science.gov (United States)

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Length. 658.13 Section 658.13 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS TRUCK SIZE AND WEIGHT, ROUTE... Network or in transit between these highways and terminals or service locations pursuant to § 658.19. (b...

13 CFR 124.403 - How is a business plan updated and modified?

Science.gov (United States)

2010-01-01

... incorporated into its business plan. The transition management strategy must describe: (1) How the Participant... business growth and promote profitable business operations after the expiration of its program term. (d... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false How is a business plan updated and...

Identification of an antifungal metabolite produced by a potential biocontrol Actinomyces strain A01 Identificação de um metabólito antifúngico produzido pela cepa Actinomyces A01

Directory of Open Access Journals (Sweden)

Cai Ge Lu

2008-12-01

inibido pelo tratamento com o caldo de fermentação da cepa A01, com eficiência superior à do pyremethanil e polyoxin. Por cromatografia em coluna e HPLC, obteve-se um composto fúngico (pureza 99,503%, cuja análise estrutural por UV, IR, MS e NMR revelou ser natamicina, um antibiótico polienico produzido por S. chattanovgensis, S. natalensis e S.gilvosporeus, empregado como conservador biológico natural em alimentos. O presente estudo relata a detecção de uma nova cepa produtora de natamicina e sua aplicação potencial como um agente de controle biológico de doenças fúngicas em plantas.

36 CFR 13.182 - Temporary facilities.

Science.gov (United States)

2010-07-01

... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Temporary facilities. 13.182... NATIONAL PARK SYSTEM UNITS IN ALASKA Cabins Use of Temporary Facilities Related to Taking Fish and Wildlife § 13.182 Temporary facilities. In a national preserve where the taking of fish and wildlife is...

13 CFR 134.213 - Discovery.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Discovery. 134.213 Section 134.213... OFFICE OF HEARINGS AND APPEALS Rules of Practice for Most Cases § 134.213 Discovery. (a) Motion. A party may obtain discovery only upon motion, and for good cause shown. (b) Forms. The forms of discovery...

10 CFR 34.13 - Specific license for industrial radiography.

Science.gov (United States)

2010-01-01

... 10 Energy 1 2010-01-01 2010-01-01 false Specific license for industrial radiography. 34.13 Section 34.13 Energy NUCLEAR REGULATORY COMMISSION LICENSES FOR INDUSTRIAL RADIOGRAPHY AND RADIATION SAFETY... industrial radiography. An application for a specific license for the use of licensed material in industrial...

Correction of quantification errors in pelvic and spinal lesions caused by ignoring higher photon attenuation of bone in [{sup 18}F]NaF PET/MR

Energy Technology Data Exchange (ETDEWEB)

Schramm, Georg, E-mail: georg.schramm@kuleuven.be; Maus, Jens; Hofheinz, Frank; Petr, Jan; Lougovski, Alexandr [Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden 01328 (Germany); Beuthien-Baumann, Bettina; Oehme, Liane [Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Dresden 01307 (Germany); Platzek, Ivan [Department of Radiology, University Hospital Carl Gustav Carus, Dresden 01307 (Germany); Hoff, Jörg van den [Helmholtz-Zentrum Dresden-Rossendorf, Institute for Radiopharmaceutical Cancer Research, Dresden 01328 (Germany); Department of Nuclear Medicine, University Hospital Carl Gustav Carus, Dresden 01307 (Germany)

2015-11-15

segmentation worked well in the pelvis and spine. However, it showed artifacts in the skull and in the extremities. The analysis of the 20 [{sup 18}F]NaF PET/MRI examinations revealed relative SUV{sub max} differences between PET{sub nobone} and PET{sub bone} of (−8.8% ± 2.7%, p = 0.01) and (−8.1% ± 1.9%, p = 2.4 × 10{sup −8}) in pelvic and spinal lesions, respectively. A maximum SUV{sub max} underestimation of −13.7% was found in lesion in the third cervical spine. The averaged SUV{sub mean} differences in volumes of interests in lung, liver, and bladder were below 3%. The average SUV{sub max} differences in pelvic and spinal lesions increased from −9% to −18% and −8% to −17%, respectively, when increasing the assigned bone attenuation coefficient from 0.11 to 0.13 cm{sup −1}. Conclusions: The developed automatic [{sup 18}F]NaF PET-based bone segmentation allows to include higher bone attenuation in whole-body MRAC and thus improves quantification accuracy for pelvic and spinal lesions in [{sup 18}F]NaF PET/MRI examinations. In nonbone structures (e.g., lung, liver, and bladder), MRAC{sub nobone} yields clinically acceptable accuracy.

50 CFR 270.13 - Books, records and reports.

Science.gov (United States)

2010-10-01

... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Books, records and reports. 270.13 Section 270.13 Wildlife and Fisheries NATIONAL MARINE FISHERIES SERVICE, NATIONAL OCEANIC AND ATMOSPHERIC... § 270.13 Books, records and reports. (a) The Council must submit to NMFS the following documents...

34 CFR 637.13 - What are design projects?

Science.gov (United States)

2010-07-01

... EDUCATION, DEPARTMENT OF EDUCATION MINORITY SCIENCE AND ENGINEERING IMPROVEMENT PROGRAM What Kinds of Projects Does the Secretary Assist Under This Program? § 637.13 What are design projects? (a) Design... 34 Education 3 2010-07-01 2010-07-01 false What are design projects? 637.13 Section 637.13...

17 CFR 8.13 - Answer to charges.

Science.gov (United States)

2010-04-01

... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Answer to charges. 8.13 Section 8.13 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION EXCHANGE PROCEDURES FOR DISCIPLINARY, SUMMARY, AND MEMBERSHIP DENIAL ACTIONS Disciplinary Procedure § 8.13 Answer to...

45 CFR 1226.13 - Obligations of sponsors.

Science.gov (United States)

2010-10-01

... 45 Public Welfare 4 2010-10-01 2010-10-01 false Obligations of sponsors. 1226.13 Section 1226.13 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE PROHIBITIONS ON ELECTORAL AND LOBBYING ACTIVITIES Sponsor Employee Activities § 1226.13...

Synthesis of 6-[18F] and 4-[18F]fluoro-L-m-tyrosines via regioselective radiofluorodestannylation

International Nuclear Information System (INIS)

Namavari, Mohammad; Satyamurthy, N.; Phelps, M.E.; Barrio, J.R.; California Univ., Los Angeles, CA

1993-01-01

The regioselective radiofluorodestannylation of 6-trimethylstannyl-L-m-tyrosine derivative with [ 18 F]F 2 and [ 18 F]acetyl hypofluorite afforded, after acid hydrolysis, 6-[ 18 F]fluoro-L-m-tyrosine in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[ 18 F]fluoro-L-m-tyrosine was synthesized in 11% radiochemical yield from the corresponding 4-trimethylstannyl-L-m-tyrosine derivative using [ 18 F]F 2 . The structural analyses of precursors, intermediates, and the final products (after 18 F decay), were carried out by 1 H, 13 C, 19 F, 119 Sn-NMR and high resolution mass spectroscopy. (author)

13 CFR 120.938 - Default.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Default. 120.938 Section 120.938... Program (504) 504 Loans and Debentures § 120.938 Default. (a) Upon occurrence of an event of default... occurrence of an event of default which does not require automatic acceleration, SBA may forbear acceleration...

13 CFR 113.500 - Employment.

Science.gov (United States)

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Employment. 113.500 Section 113... Discrimination on the Basis of Sex in Employment in Education Programs Or Activities Prohibited § 113.500 Employment. (a) General. (1) No person shall, on the basis of sex, be excluded from participation in, be...

13 CFR 120.934 - Collateral.

Science.gov (United States)

2010-01-01

... Loan Program (504) 504 Loans and Debentures § 120.934 Collateral. The CDC usually takes a second lien position on the Project Property to secure the 504 loan. Sometimes additional collateral is required. (In... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Collateral. 120.934 Section 120...

16 CFR 1702.13 - Labeling and packaging samples.

Science.gov (United States)

2010-01-01

... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Labeling and packaging samples. 1702.13 Section 1702.13 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION POISON PREVENTION PACKAGING ACT OF 1970 REGULATIONS PETITIONS FOR EXEMPTIONS FROM POISON PREVENTION PACKAGING ACT REQUIREMENTS; PETITION...

33 CFR 157.12f - Workshop functional test requirements.

Science.gov (United States)

2010-07-01