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Sample records for eyes open closed

  1. Results of the Schirmer tear test performed with open and closed eyes in clinically normal horses.

    Science.gov (United States)

    Trbolova, Alexandra; Ghaffari, Masoud Selk

    2017-05-31

    The Schirmer tear test (STT) is widely used in both human and veterinary ophthalmology. Two types of STTs have been developed: STT I and SST II. The STT I measures the basal and reflex tear production and is the most widely used STT. However, several factors influence the STT results such as the person performing the test and the location of the strip placement within the conjunctival sac. The aim of this study was to measure the basal and reflex tear production (STT I) in clinically normal horses with open versus closed eyes. Forty clinically healthy horses without any ocular diseases were included. On day 1, the STT I was first performed on all the horses with the eyes open followed by an STT I with closed eyes performed 30 min later. On day 2, all horses had their eyes closed during the first STT and the eyes open during the second test performed 30 min later. The mean value of the STTs performed on open eye was significantly less than the STT performed on closed eye on both days of examination. This study showed a small but statistically significant difference between STT values obtained with open versus closed eyes in clinically normal horses.

  2. Aetiology and outcome of open and closed globe eye injuries in children.

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    Kadappu, Subhashini; Silveira, Sue; Martin, Frank

    2013-07-01

    This paper reports on the aetiology and outcome of childhood open and closed globe eye injuries presenting to the Children's Hospital at Westmead, Sydney, Australia from January 2000 to December 2008. Hospital-based retrospective study. Two hundred three cases of childhood eye injuries identified in a nine-year period, comprising 81 open globe and 122 closed globe injuries. Hospital records were examined for demographic data and injuries were classified into open globe and closed globe, based on the Ocular Trauma Classification. Parameters affecting the final visual outcome such as type of injury, zone of injury, initial visual acuity, wound length (only in open globe injuries) and lens injury were assessed. Most of the eye injuries resulted from the child poking itself or being poked accidentally (26%), with the home being the most common place of injury. A favourable visual outcome was noted with closed globe injuries as compared with open globe injuries (P globe ruptures, zone 3 injuries, poor initial visual acuity, wound length >10 mm and lens trauma. Final visual acuity of 6/12 or better was observed in 68% of injured eyes. This study demonstrated improved visual outcomes when compared with previous studies. However, many unsalvageable childhood eye injuries with little useful vision were evident, and most disconcerting is that the majority of childhood eye injuries in this study were preventable. © 2012 The Authors. Clinical and Experimental Ophthalmology © 2012 Royal Australian and New Zealand College of Ophthalmologists.

  3. Multi-modal causality analysis of eyes-open and eyes-closed data from simultaneously recorded EEG and MEG.

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    Anwar, Abdul Rauf; Mideska, Kidist Gebremariam; Hellriegel, Helge; Hoogenboom, Nienke; Krause, Holger; Schnitzler, Alfons; Deuschl, Günther; Raethjen, Jan; Heute, Ulrich; Muthuraman, Muthuraman

    2014-01-01

    Owing to the recent advances in multi-modal data analysis, the aim of the present study was to analyze the functional network of the brain which remained the same during the eyes-open (EO) and eyes-closed (EC) resting task. The simultaneously recorded electroencephalogram (EEG) and magnetoencephalogram (MEG) were used for this study, recorded from five distinct cortical regions of the brain. We focused on the 'alpha' functional network, corresponding to the individual peak frequency in the alpha band. The total data set of 120 seconds was divided into three segments of 18 seconds each, taken from start, middle, and end of the recording. This segmentation allowed us to analyze the evolution of the underlying functional network. The method of time-resolved partial directed coherence (tPDC) was used to assess the causality. This method allowed us to focus on the individual peak frequency in the 'alpha' band (7-13 Hz). Because of the significantly higher power in the recorded EEG in comparison to MEG, at the individual peak frequency of the alpha band, results rely only on EEG. The MEG was used only for comparison. Our results show that different regions of the brain start to `disconnect' from one another over the course of time. The driving signals, along with the feedback signals between different cortical regions start to recede over time. This shows that, with the course of rest, brain regions reduce communication with each another.

  4. A Study of Deep CNN-Based Classification of Open and Closed Eyes Using a Visible Light Camera Sensor

    Directory of Open Access Journals (Sweden)

    Ki Wan Kim

    2017-06-01

    Full Text Available The necessity for the classification of open and closed eyes is increasing in various fields, including analysis of eye fatigue in 3D TVs, analysis of the psychological states of test subjects, and eye status tracking-based driver drowsiness detection. Previous studies have used various methods to distinguish between open and closed eyes, such as classifiers based on the features obtained from image binarization, edge operators, or texture analysis. However, when it comes to eye images with different lighting conditions and resolutions, it can be difficult to find an optimal threshold for image binarization or optimal filters for edge and texture extraction. In order to address this issue, we propose a method to classify open and closed eye images with different conditions, acquired by a visible light camera, using a deep residual convolutional neural network. After conducting performance analysis on both self-collected and open databases, we have determined that the classification accuracy of the proposed method is superior to that of existing methods.

  5. Amplitude differences in high-frequency fMRI signals between eyes open and eyes closed resting states.

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    Yuan, Bin-Ke; Wang, Jue; Zang, Yu-Feng; Liu, Dong-Qiang

    2014-01-01

    Recent studies employing rapid sampling techniques have demonstrated that the resting state fMRI (rs-fMRI) signal exhibits synchronized activities at frequencies much higher than the conventional frequency range (high-frequency fluctuations between different resting states. Here, we acquired rs-fMRI data at a high sampling rate (TR = 400 ms) from subjects with both eyes open (EO) and eyes closed (EC), and compared the amplitude of fluctuation (AF) between EO and EC for both the low- and high-frequency components. In addition to robust AF differences in the conventional low frequency band (high-frequency (primarily in 0.1-0.35 Hz) differences. The high-frequency results without covariates regression exhibited noisy patterns. For the data with nuisance covariates regression, we found a significant and reproducible reduction in high-frequency AF between EO and EC in the bilateral PSMC and the supplementary motor area (SMA), and an increase in high-frequency AF in the left middle occipital gyrus (MOG). Furthermore, we investigated the effect of sampling rate by down-sampling the data to effective TR = 2 s. Briefly, by using the rapid sampling rate, we were able to detect more regions with significant differences while identifying fewer artifactual differences in the high-frequency bands as compared to the down-sampled dataset. We concluded that (1) high-frequency fluctuations of rs-fMRI signals can be modulated by different resting states and thus may be of physiological importance; and (2) the regression of covariates and the use of fast sampling rates are superior for revealing high-frequency differences in rs-fMRI signals.

  6. Directionality of large-scale resting-state brain networks during eyes open and eyes closed conditions

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    Delong eZhang

    2015-02-01

    Full Text Available The present study examined directional connections in the brain among resting-state networks (RSNs when the participant had their eyes open (EO or had their eyes closed (EC. The resting-state fMRI data were collected from 20 healthy participants (11 males, 20.17 ± 2.74 years under the EO and EC states. Independent component analysis (ICA was applied to identify the separated RSNs (i.e., the primary/high-level visual, primary sensory-motor, ventral motor, salience/dorsal attention, and anterior/posterior default-mode networks, and the Gaussian Bayesian network (BN learning approach was then used to explore the conditional dependencies among these RSNs. The network-to-network directional connections related to EO and EC were depicted, and a support vector machine (SVM was further employed to identify the directional connection patterns that could effectively discriminate between the two states. The results indicated that the connections among RSNs are directionally connected within a BN during the EO and EC states. The directional connections from the salient attention network to the anterior/posterior default-mode networks and the high-level to primary-level visual network were the obvious characteristics of both the EO and EC resting-state BNs. Of the directional connections in BN, the attention (salient and dorsal-related directional connections were observed to be discriminative between the EO and EC states. In particular, we noted that the properties of the salient and dorsal attention networks were in opposite directions. Overall, the present study described the directional connections of RSNs using a BN learning approach during the EO and EC states, and the results suggested that the attention system (the salient and the dorsal attention network might have important roles in resting-state brain networks and the neural substrate underpinning of switching between the EO and EC states.

  7. The effects of wobble board training on the eyes open and closed static balance ability of adolescents with down syndrome.

    Science.gov (United States)

    Park, Tae-Jin

    2014-04-01

    [Purpose] The aim of the present study was to examine the influence of wobble board training on static balance, with and without vision, of adolescents with Down syndrome (DS). [Subjects] Ten adolescents with DS were recruited for this study. [Methods] Participants performed quiet standing with their eyes open and closed, pre- and post-wobble board training. During quiet standing, the center of pressure (COP) data was recorded using a force plate. To assess the static balance ability of the participants, the 95% confidence ellipse area of COP was calculated. The paired t-test was used to compare the 95% confidence ellipse area of COP between the eyes open and closed conditions, and between pre- and post-training. [Results] Although there was no significant difference in the 95% confidence ellipse area of COP between with and without vision, the 95% confidence ellipse area of COP decreased significantly after wobble board training. [Conclusion] These findings suggest that wobble board training is an effective at improving the static balance ability of adolescents with DS.

  8. The Number of Pulses Needed to Measure Corticospinal Excitability by Navigated Transcranial Magnetic Stimulation: Eyes Open vs. Close Condition

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    Bashir, Shahid; Yoo, Woo-Kyoung; Kim, Hyoung Seop; Lim, Hyun Sun; Rotenberg, Alexander; Abu Jamea, Abdullah

    2017-01-01

    Objective: Motor evoked potentials (MEPs) obtained by transcranial magnetic stimulation (TMS) enable measures of the corticospinal excitability (CSE). However the reliability of TMS-derived CSE measures is suboptimal due to appreciable pulse-to-pulse MEP amplitude variability. We thus calculated how many TMS–derived MEPs will be needed to obtain a reliable CSE measure in awake adult subjects, in the eyes open (EO) and eyes closed (EC) conditions. Methods: Twenty healthy adults (70% male) received 40 consecutive navigated TMS pulses (120% resting motor threshold, RMT) in the EO or EC conditions on two separate days in randomized order. Results: For either the EO or EC condition, the probability that the 95% confidence interval (CI) derived from consecutive MEP amplitude measured included the true CSE, increased when the number of consecutive stimuli increased (EO: p = 0.05; EC: p = 0.001). No significant effect of RMT, Mini-Mental State Examination (MMSE) score, or gender on the CSE estimates was identified. At least 34 consecutive stimuli were required to obtain a most reliable CSE estimate in the EO condition and 31 in the EC condition. Conclusion: Our findings indicate that >30 consecutive MEPs may be necessary in order to obtain a CSE measure in healthy adults.

  9. "Eyes Open - Eyes Closed" EEG/fMRI data set including dedicated "Carbon Wire Loop" motion detection channels.

    Science.gov (United States)

    van der Meer, Johan; Pampel, André; van Someren, Eus; Ramautar, Jennifer; van der Werf, Ysbrand; Gomez-Herrero, German; Lepsien, Jöran; Hellrung, Lydia; Hinrichs, Hermann; Möller, Harald; Walter, Martin

    2016-06-01

    This data set contains electroencephalography (EEG) data as well as simultaneous EEG with functional magnetic resonance imaging (EEG/fMRI) data. During EEG/fMRI, the EEG cap was outfitted with a hardware-based add-on consisting of carbon-wire loops (CWL). These yielded six extra׳CWL׳ signals related to Faraday induction of these loops in the main magnetic field "Measurement and reduction of motion and ballistocardiogram artefacts from simultaneous EEG and fMRI recordings" (Masterton et al., 2007) [1]. In this data set, the CWL data make it possible to do a direct regression approach to deal with the BCG and specifically He artifact. The CWL-EEG/fMRI data in this paper has been recorded on two MRI scanners with different Helium pump systems (4 subjects on a 3 T TIM Trio and 4 subjects on a 3T VERIO). Separate EEG/fMRI data sets have been recorded for the helium pump ON as well as the helium pump OFF conditions. The EEG-only data (same subjects) has been recorded for a motion artifact-free reference EEG signal outside of the scanner. This paper also links to an EEGlab "EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis" (Delorme and Makeig, 2004) [2] plugin to perform a CWL regression approach to deal with the He pump artifact, as published in the main paper "Carbon-wire loop based artifact correction outperforms post-processing EEG/fMRI corrections-A validation of a real-time simultaneous EEG/fMRI correction method" (van der Meer et al., 2016) [3].

  10. Brain spontaneous fluctuations in sensorimotor regions were directly related to eyes open and eyes closed: evidences from a machine learning approach

    Directory of Open Access Journals (Sweden)

    Bishan eLiang

    2014-08-01

    Full Text Available Previous studies have demonstrated that the difference between resting-state brain activations depends on whether the subject was eyes open (EO or eyes closed (EC. However, whether the spontaneous fluctuations are directly related to these two different resting states are still largely unclear. In the present study, we acquired resting-state functional magnetic resonance imaging data from 24 healthy subjects (11 males, 20.17 ± 2.74 years under the EO and EC states. The amplitude of the spontaneous brain activity in low-frequency band was subsequently investigated by using the metric of fractional amplitude of low frequency fluctuation (fALFF for each subject under each state. A support vector machine (SVM analysis was then applied to evaluate whether the category of resting states could be determined from the brain spontaneous fluctuations. We demonstrated that these two resting states could be decoded from the identified pattern of brain spontaneous fluctuations, predominantly based on fALFF in the sensorimotor module. Specifically, we observed prominent relationships between increased fALFF for EC and decreased fALFF for EO in sensorimotor regions. Overall, the present results indicate that a SVM performs well in the discrimination between the brain spontaneous fluctuations of distinct resting states and provide new insight into the neural substrate of the resting states during EC and EO.

  11. [Comparative analysis of ethanol effects on the spatial organization of biopotentials under conditions of open and closed eyes during different types of thinking].

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    Dorokhov, V B; Sviderskaia, N E; Zakharchenko, D V; Antonov, A G

    2011-01-01

    Effects of low doses of ethanol on indices of spatial organization of cortical potentials (spatial synchronization, coherence, spectral power and information-power index) under the closed- and open-eyes conditions and during performance of divergent and convergent non-verbal and verbal tasks. Ethanol effect was shown to be more expressed under the open eyes-conditions as compared to that with the closed eyes. This finding may be associated with the greater effect of the stream of afferent information in the former case. Changes in topographical characteristics of the spatial synchronization of cortical potentials were more clearly localized and "specific" during divergent thinking as compared to the convergent type. Changes in the spectral power and information-power index testify to greater sensitivity to ethanol of divergent type of thinking as compared to convergent type. Psychological testing of stress resistance and impulsivity also showed a greater effect of ethanol on divergent thinking.

  12. Wartime open globe eye injuries.

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    Plestina-Borjan, Ivna; Medvidovic-Grubisic, Maria; Zuljan, Igor; Lakos, Venera; Miljak, Snjezana; Markovic, Irena; Ivanisevic, Milan

    2010-03-01

    Open globe injuries are the most serious eye injuries in war as in peace time. The purpose of this study is to analyze wartime open globe eye injuries in 72 patients treated at the Department of Ophthalmology, Clinical Hospital of Split from July 1991 to April 1993, during the intensive war in Croatia and Bosnia and Herzegovina, and to evaluate crucial factors responsible for the functional success of the treatment. Wartime open globe eye injuries were retrospectively analyzed in 72 patients (80 eyes) hospitalized at Clinical Hospital of Split, Department of Ophthalmology, between July 1991 and April 1993. The causes and ways of wounding, localization of wounds and presence, nature and localization of the foreign body, as well as admission time, microsurgical management and other factors contributing to poor visual outcome were studied. Standard international classification of ocular traumas (the Birmingham Eye Trauma Terminology and the International Ocular Trauma Classification) was used for the classified and graded injuries. Open globe eye injuries amounted to 52.65% of all war injuries to the eyes. Bilateral injuries were found in eight patients (11.11%). The most frequent cause of the injures were fragments of explosive devices (more than two-thirds). Most of the patients were admitted to the hospital within 24 hours of the injury. Using current microsurgical techniques, the attempt was made to achieve not only anatomical but also functional recovery already in the primary treatment. In 30 eyes (37.50%) final visual acuity amounted to more than 0.1, and in 22 eyes (27.50%) it reached 0.5. There was a statistically significant correlation between admission within the first 12 hours and postoperative improved visual acuity (chi(2) = 4.53; p = 0.033). Statistically significantly better visual acuity was found in patients with lesions limited to the anterior segment of the eye. Primary enucleation or evisceration was performed only exceptionally: one enucleation

  13. Revisiting the eye opening response of the Glasgow Coma Scale

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    Taopheeq Bamidele Rabiu

    2011-01-01

    Full Text Available The Glasgow Coma Scale (GCS, introduced by Teasdale and Jenneth in 1974, has received tremendous acclaim from clinicians and has been extensively used in clinical practice for the evaluation of the level of consciousness. The author notes that some traumatic brain injury patients close eyes in response to painful stimuli as opposed to the eye opening response to pain of the GCS. A revision of the eye opening response subsection of the GCS is suggested.

  14. 静息睁闭眼状态脑电信号特征分析%Analysis on the EEG Characteristics under Eyes Open and Closed States

    Institute of Scientific and Technical Information of China (English)

    高伊蒙; 朱守林; 高明星; 戚春华; 杨锋

    2015-01-01

    The characteristics of EEG at indoor environment have relations with that in the actual driving state , especially in the intensity of alpha and beta waves .The MP150 multi channel physiological signal acquisition instrument was used to collect the data of different drivers’EEG signal under eyes open and closed states with peace .The Acqknowledge software was then used to separate the alpha and beta waves .According to the analysis on the average power of alpha and beta waves in the same time quantum , combined with the subjects ’temperament types , the following results were obtained: alpha wave was instable and easy to be disturbed and changed under different experimental conditions .What’s more, in the same period of EEG signal , the change range of beta wave form was much smaller than that of alpha wave form .The results showed that using beta wave of EEG signal as analysis index was more rea -sonable than using alpha wave at the dynamic measurement and the eye-open state, which can be used as references for obtaining the EEG signal of drivers in grassland highways .%驾驶员的脑电信号特征在实际行车时与室内状态下具有一定联系,尤其表现在α波和β波的活动强弱上。利用MP150多通道生理信号采集仪对不同受试者静息状态睁眼和闭眼时的脑电信号进行采集,并在Acqknowledge 软件上分离出α波和β波,通过对受试者同一时间段内α波和β波的平均功率分析,并结合受试者气质类型进行深入研究,得到以下结果:α波活动并不稳定,因实验条件的不同容易受到干扰而发生改变;在相同一段EEG信号中,β波的波形变化幅度相对于α波要小很多。由分析结果可见,动态测量和睁眼状态时,利用脑电信号β波作为分析指标比α波更为合理。由此,可为草原公路实驾过程中驾驶员脑电信号的提取提供一定的参考。

  15. Open your eyes and vote!

    CERN Multimedia

    Rebecca Leam

    The CERN film-making club is organizing the second edition of the CinéGlobe International Short Film Festival and everyone is invited to attend a series of selection screenings in November to vote on which they like and think should be publicly shown in the Globe and at the Forum Meyrin in February 2010.   This year over 700 short films were submitted for three competitions: the majority for the general fiction category for films up to ten minutes in length, and others for science fiction (20 minutes) and science documentary (30 minutes). “In 2007 we had just one competition open to films from any genre. We decided to add the science related competitions to the second edition to make a stronger link with CERN as a physics lab,” explained Quentin King, Chairman of the Selection Committee and member of CERN’s film-making club, Open Your Eyes Films. “The entries are extremely diverse and touch on almost every aspect of life. The creativity of short...

  16. Schirmer test performed with open and closed eyes: variations in normal individuals Comparação entre os testes de Schirmer em olhos abertos e fechados em indivíduos normais

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    Leão Gabbay Serruya

    2009-02-01

    Full Text Available PURPOSE: To analyze the difference between measurements of Schirmer test I (ST I and basal Schirmer test (STB with open and closed eyes. METHODS: Sixty eyes of 30 normal volunteers, 12 males and 18 females aged 28 ± 9 years were recruited for the study. All ST were carried out in a closed environment with the absence of airflow (humidity 60 ± 2.34% and temperature 20.72 ± 1.52ºC. ST I and ST B were performed with the individuals' both eyes open and closed with an interval of 6 hours. All ST were conducted in 5 minutes. For statistical analysis, the ST strip's wetting velocity (ST V (in millimeters per minute was calculated, dividing the ST values by its wetting time. If ST values were 35mm before 5 minutes, wetting time was recorded to obtain ST V. RESULTS: ST V measurements of ST I performed with closed eyes (10.30 ± 11.55 were statistically different from those performed with open eyes (18.85 ± 17.88 and ST V measurements of STB performed with closed eyes (3.74 ± 3.14 were statistically different from those performed with open eyes (6.19 ± 5.86. CONCLUSION: ST performed with open or closed eyes can have an important influence in the results of ST I and STB in normal individuals.OBJETIVO: Analisar a diferença das medidas dos testes de Schirmer I e Schirmer basal realizados com os olhos abertos e olhos fechados. MÉTODOS: Foram analisados 60 olhos de 30 indivíduos normais com idade média de 28 ± 9 anos. A umidade média do ar foi de 60 ± 2,34% e a temperatura média de 20,72 ± 1,52ºC. No primeiro dia, foi feito o teste de Schirmer I com os olhos abertos. Após um intervalo de 6 horas, foi realizado o teste de Schirmer I com os olhos fechados. No segundo dia, foi realizado o mesmo procedimento com o teste de Schirmer basal. Para fins de comparação, as medidas das tiras de papel foram divididas pelo tempo de umedecimento das tiras (velocidade para análise estatística. RESULTADOS:No teste de Schirmer I realizado com os olhos

  17. Eyes wide shut: amygdala mediates eyes-closed effect on emotional experience with music.

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    Yulia Lerner

    Full Text Available The perceived emotional value of stimuli and, as a consequence the subjective emotional experience with them, can be affected by context-dependent styles of processing. Therefore, the investigation of the neural correlates of emotional experience requires accounting for such a variable, a matter of an experimental challenge. Closing the eyes affects the style of attending to auditory stimuli by modifying the perceptual relationship with the environment without changing the stimulus itself. In the current study, we used fMRI to characterize the neural mediators of such modification on the experience of emotionality in music. We assumed that closed eyes position will reveal interplay between different levels of neural processing of emotions. More specifically, we focused on the amygdala as a central node of the limbic system and on its co-activation with the Locus Ceruleus (LC and Ventral Prefrontal Cortex (VPFC; regions involved in processing of, respectively, 'low', visceral-, and 'high', cognitive-related, values of emotional stimuli. Fifteen healthy subjects listened to negative and neutral music excerpts with eyes closed or open. As expected, behavioral results showed that closing the eyes while listening to emotional music resulted in enhanced rating of emotionality, specifically of negative music. In correspondence, fMRI results showed greater activation in the amygdala when subjects listened to the emotional music with eyes closed relative to eyes open. More so, by using voxel-based correlation and a dynamic causal model analyses we demonstrated that increased amygdala activation to negative music with eyes closed led to increased activations in the LC and VPFC. This finding supports a system-based model of perceived emotionality in which the amygdala has a central role in mediating the effect of context-based processing style by recruiting neural operations involved in both visceral (i.e. 'low' and cognitive (i.e. 'high' related processes

  18. Blind Ethics: Closing One's Eyes Polarizes Moral Judgments and Discourages Dishonest Behavior

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    Caruso, Eugene M.; Gino, Francesca

    2011-01-01

    Four experiments demonstrate that closing one's eyes affects ethical judgment and behavior because it induces people to mentally simulate events more extensively. People who considered situations with their eyes closed rather than open judged immoral behaviors as more unethical and moral behaviors as more ethical. In addition, considering…

  19. Opening and Closing in Open Systems.

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    Klapp, Orrin E.

    In open information systems, such as in the case of human interchange with the self and the environment, input quantities have no upper limits. The human information utilization system, however, is psychologically and behaviorally unable to accept ever increasing loads of information. Because of this apparent fact, human information systems should…

  20. Commentary: open access, open business, closed fairness!

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    Moustafa, Khaled

    2015-01-01

    A strong trend to move from print to online publication is largely perceived in scientific and nonscientific fields. A growing number of publishers increasingly opt for online publication as an option or a compulsory alternative. From readers' perspective, this is a highly appreciated facility, but from the author's, things are different mainly because of excessive article processing charges (APC) that make the open access system sometimes as a hindrance for many authors but a lucrative enterprise for many shareholders, enticing the most traditional and conservative publishers.

  1. EYE TRAUMA. OPEN GLOBE INJURY MANAGEMENT

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    Mojca Globočnik Petrovič

    2004-05-01

    Full Text Available Background. Ocular trauma is important cause of blindness. Birmingham Eye Trauma Terminology allows us to use a standardized eye injury terminology which permits an unambigous interpretation. The Eye Injury Registry enables the analysis of medical, epidemyologic and social data.The most frequent ocular injury ocular contusion has a relatively good prognosis. An adequate primary ocular repair and correct timing of pars plana vitrectomy are very important in open globe injury management. There still exist some controversial issues concerning the role of posterior segment surgery in open globe injuries. These include timing of surgery, prophylactic scleral buckle placement and a proper use of systemic and intravitreal antibiotics.Conclusions. With adequate primary ocular repair, the use of systemic, intravitreal antibiotics, scleral buckling and proper timing for pars plana vitrectomy the prognosis for ocular trauma cases can be better.

  2. Equivalence of open/closed strings

    CERN Document Server

    Wang, Peng; Yang, Haitang

    2015-01-01

    In this paper, we prove that the open and closed strings are $O(D,D)$ equivalent. The equivalence requires an AdS geometry near the boundaries. The $O(D,D)$ invariance is introduced into the Polyakov action by the Tseytlin's action. Traditionally, there exist disconnected open-open or closed-closed configurations in the solution space of the Tseytlin's action. The open-closed configuration is ruled out by the mixed terms of the dual fields. We show that, under some very general guidances, the dual fields are consistently decoupled if and only if the near horizon geometry is $AdS_5$. We then have open-closed and closed-open configurations in different limits of the distances of the $D3$-brane pairs. Inherited from the definition of the theory, these four configurations are of course related to each other by $O(D,D)$ transformations. We therefore conclude that both the open/closed relation and open/closed duality can be derived from $O(D,D)$ symmetries. By analyzing the couplings of the configurations, the low ...

  3. Closed suction system versus open suction

    National Research Council Canada - National Science Library

    Elmansoury, Ahmed; Said, Hedya

    Background: Catheter suction is used to remove tracheal secretions through the endotracheal tube in mechanically ventilated patients, which may be either closed tracheal suction system (CTSS) or open one...

  4. 77 FR 55852 - National Eye Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-09-11

    ..., National Eye Institute, Bethesda, MD 20892, (301) 451-6763. In the interest of security, NIH has instituted... state the purpose of their visit. Information is also available on the Institute's/Center's home page... HUMAN SERVICES National Institutes of Health National Eye Institute; Notice of Closed Meeting...

  5. 75 FR 57968 - National Eye Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-09-23

    ... Institute, Bethesda, MD 20892, (301) 451-6763. In the interest of security, NIH has instituted stringent... purpose of their visit. Information is also available on the Institute's/Center's home page: http://www... HUMAN SERVICES National Institutes of Health National Eye Institute; Notice of Closed Meeting...

  6. 77 FR 8266 - National Eye Institute; Notice of Closed Meeting

    Science.gov (United States)

    2012-02-14

    ... Institute, Bethesda, MD 20892, (301) 451-6763. In the interest of security, NIH has instituted stringent... purpose of their visit. Information is also available on the Institute's/Center's home page: www.nei.nih... HUMAN SERVICES National Institutes of Health National Eye Institute; Notice of Closed Meeting...

  7. The management of open globe eye injuries: a discussion of the classification, diagnosis and management of open globe eye injuries.

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    Ritson, J E; Welch, J

    2013-01-01

    Eye injuries occurred in 10% of UK military major trauma cases in Iraq and Afghanistan between 2004 and 2008, with 33% of these eye injuries open globe in nature(1). This article will consider the diagnosis, classification and management of open globe injuries in the role 1/ pre-hospital environment.

  8. Closed-loop, open-source electrophysiology

    Directory of Open Access Journals (Sweden)

    John D Rolston

    2010-09-01

    Full Text Available Multiple extracellular microelectrodes (multi-electrode arrays, or MEAs effectively record rapidly varying neural signals, and can also be used for electrical stimulation. Multi-electrode recording can serve as artificial output (efferents from a neural system, while complex spatially and temporally targeted stimulation can serve as artificial input (afferents to the neuronal network. Multi-unit or local field potential recordings can not only be used to control real world artifacts, such as prostheses, computers or robots, but can also trigger or alter subsequent stimulation. Real-time feedback stimulation may serve to modulate or normalize aberrant neural activity, to induce plasticity, or to serve as artificial sensory input. Despite promising closed-loop applications, commercial electrophysiology systems do not yet take advantage of the bidirectional capabilities of multi-electrodes, especially for use in freely moving animals. We addressed this lack of tools for closing the loop with NeuroRighter, an open-source system including recording hardware, stimulation hardware, and control software with a graphical user interface. The integrated system is capable of multi-electrode recording and simultaneous patterned microstimulation triggered by recordings with minimal stimulation artifact. The potential applications of closed-loop systems as research tools and clinical treatments are broad; we provide one example where epileptic activity recorded by a multi-electrode probe is used to trigger targeted stimulation, via that probe, to freely moving rodents.

  9. Open string amplitudes of closed topological vertex

    CERN Document Server

    Takasaki, Kanehisa

    2016-01-01

    The closed topological vertex is the simplest "off-strip" case of non-compact toric Calabi-Yau threefolds with acyclic web diagrams. By the diagrammatic method of topological vertex, open string amplitudes of topological string theory therein can be obtained by gluing a single topological vertex to an "on-strip" subdiagram of the tree-like web diagram. If non-trivial partitions are assigned to just two parallel external lines of the web diagram, the amplitudes can be calculated with the aid of techniques borrowed from the melting crystal models. These amplitudes are thereby expressed as matrix elements, modified by simple prefactors, of an operator product on the Fock space of 2D charged free fermions. This fermionic expression can be used to derive $q$-difference equations for generating functions of special subsets of the amplitudes. These $q$-difference equations may be interpreted as the defining equation of a quantum mirror curve.

  10. Impaired Saccadic Eye Movement in Primary Open-angle Glaucoma

    DEFF Research Database (Denmark)

    Lamirel, Cédric; Milea, Dan; Cochereau, Isabelle

    2013-01-01

    PURPOSE:: Our study aimed at investigating the extent to which saccadic eye movements are disrupted in patients with primary open-angle glaucoma (POAG). This approach followed upon the discovery of differences in the eye-movement behavior of POAG patients during the exploration of complex visual...... scenes. METHODS:: The eye movements of 8 POAG patients and 4 healthy age-matched controls were recorded. Four of the patients had documented visual field scotoma, and 4 had no identifiable scotoma on visual field testing. The eye movements were monitored as the observers watched static and kinetic...

  11. Outgassing from Open and Closed Magma Foams

    Directory of Open Access Journals (Sweden)

    Felix W. von Aulock

    2017-06-01

    Full Text Available During magma ascent, bubbles nucleate, grow, coalesce, and form a variably permeable porous network. The reorganization, failing and sealing of bubble walls may contribute to the opening and closing of the volcanic system. In this contribution we cause obsidian to nucleate and grow bubbles to high gas volume fraction at atmospheric pressure by heating samples to 950°C for different times and we image the growth through a furnace. Following the experiment, we imaged the internal pore structure of selected samples in 3D and then dissected for analysis of textures and dissolved water content remnant in the glass. We demonstrate that in these high viscosity systems, during foaming and subsequent foam-maturation, bubbles near a free surface resorb via diffusion to produce an impermeable skin of melt around a foam. The skin thickens non-linearly through time. The water concentrations at the outer and inner skin margins reflect the solubility of water in the melt at the partial pressure of water in atmospheric and water-rich bubble conditions, respectively. In this regime, mass transfer of water out of the system is diffusion limited and the sample shrinks slowly. In a second set of experiments in which we polished off the skin of the foamed samples and placed them back in the furnace to allow open system outgassing, we observe rapid sample contraction and collapse of the connected pore network under surface tension as the system efficiently outgasses. In this regime, mass transfer of water is permeability limited. We conclude that diffusion-driven skin formation can efficiently seal connectivity in foams. When rupture of melt film around gas bubbles (i.e., skin removal occurs, then rapid outgassing and consequent foam collapse modulate gas pressurization in the vesiculated magma. The mechanisms described here are relevant to the evolution of pore network heterogeneity in permeable magmas.

  12. Efficacy of an Amblyopia Treatment Program with Both Eyes Open: A Functional Near-Infrared Spectroscopy Study.

    Science.gov (United States)

    Iwata, Yo; Handa, Tomoya; Ishikawa, Hitoshi; Shoji, Nobuyuki; Shimizu, Kimiya

    2016-01-01

    To investigate the efficacy of an amblyopia treatment program with both eyes open. Ten subjects (mean age 20.5 ± 1.5 years) were enrolled. All subjects had un-remarkable ophthalmic examinations, but several subjects had minor refractive errors. Vision function was evaluated using the 3-D visual function trainer-ORTe. Brain measurements were made using functional near-infrared spectroscopy (fNIRS) to examine the oxygenated hemoglobin (HbO2) concentration change upon visual stimulus presentation. The three conditions were as follows: both eyes open and both eyes stimulated, both eyes open and only one eye stimulated, and one eye open and one eye stimulated. Changes in HbO2 between the rest and stimulation phases were not statistically different between the unilateral and bilateral stimulation conditions with both eyes open. However, HbO2 change was significantly higher in subjects with both eyes open than in subjects with one eye closed (P amblyopia treatment administered without occluding the healthy eye may provide the greatest therapeutic benefit. © 2016 Board of regents of the University of Wisconsin System, American Orthoptic Journal, Volume 66, 2016, ISSN 0065-955X, E-ISSN 1553-4448.

  13. An open mind to closed borders

    Science.gov (United States)

    Fallet, Ulrike; Lefeber, Bob

    2017-04-01

    answer to this polarizing question, students got clues, which they had to analyse and discuss. Through solving this migration mystery, high-school students were encouraged to keep 'an open mind to closed borders' and learned important steps of the scientific thinking process as well as experience the nuance in a widely discussed civic case.

  14. Assessments: An Open and Closed Case

    Science.gov (United States)

    Khan, R. Nazim

    2015-01-01

    Open book assessment is not a new idea, but it does not seem to have gained ground in higher education. In particular, not much literature is available on open book examinations in mathematics and statistics in higher education. The objective of this paper is to investigate the appropriateness of open book assessments in a first-year business…

  15. "Big Eye"Soon to Open

    Institute of Scientific and Technical Information of China (English)

    Rose Yan

    2009-01-01

    @@ On November 6,"Beijing Auto Museum Collection Review Exhibition and Construction Development Symposium"was held in the Beijing Auto Museum which was still under construction.This symposium was sponsored by Fengtai District Government and undertaken jointly by Beijing Auto Museum and China Automotive engineering Academic Society,aiming at placing the foundation for the opening of the Museum.

  16. Panorama of the Opening-Closing Tectonics Theory in China

    Institute of Scientific and Technical Information of China (English)

    YANG Weiran; ZHENG Jiandong

    2004-01-01

    The opening-closing tectonics theory, a theory about opening-closing tectonics, is a viewpoint regarding geotectonics suggested by a group of Chinese scientists. Opening and closing are two basic geological movements, which may result in a series of structures. The highest level of opening is the appearance of oceans and the highest level of closing is the consolidation of continents. Based on field investigations, the authors consider that identifying the marks of openingclosing tectonics is the basis of the issue and classifying the types of opening-closing tectonics is the key of the issue. This paper briefly discusses the substance and the future of the study on the opening-closing tectonics in China. The authors hope to share relevant information with geoscientists in the world in this field.

  17. Eye-openers from XMM-Newton

    Science.gov (United States)

    2000-02-01

    The images were obtained between 19-25 January at the very start of the science payload commissioning process. The spacecraft viewed three regions of the sky: part of the Large Magellanic Cloud (LMC), the Hickson Cluster Group 16 (HCG-16), and the star HR 1099. These targets were chosen because they all present a variety of X-ray extended and point sources and are very interesting regions. The expanding cauldon in the Large Magellanic Cloud The Large Magellanic Cloud also known as the Nebula Major is about 20 thousand light years in diameter. Situated 160 thousand light years from Earth, it is one of two irregularly shaped galaxies that are easily seen with the naked eye in the southern hemisphere. These galaxies are satellites of the Milky Way and appear to be slowly spiralling into our own Galaxy. The first image obtained by the EPIC-PN X-ray cameras viewed the 30 Doradus region of the Large Magellanic Cloud. Also called the Tarantula Nebula, 30 Doradus is a cauldron of creation where exploding stars are releasing vast amounts of matter and where new stars are being born. The image presents the million degree temperatures of the emitting medium, with blue indicating the hottest regions; green intermediate temperatures and red the coldest regions. The white and blue arc-like formation just off the centre is a new object, only part of which was known in the past. It has the appearance of a supernova remnant with its expanding glowing-hot gas producing X-ray emission as it collides with the interstellar medium. On the lower right of the picture is the remains of a star that exploded as Supernova 1987A on 24 February 1987. It was the first supernova to reach naked-eye brightness since 1604 (Kepler's star) and remained visible to the naked eye for nearly nine months. The brightest source in the view, upper left, is another supernova remnant (N157D). Martin Turner, Principal Investigator for the EPIC cameras... "These first pictures are tremendously exciting after so

  18. Open and Closed Form in Interactive Music

    DEFF Research Database (Denmark)

    Graugaard, Lars

    2005-01-01

    Performing music includes substantial listening skills on part of the performer. Performing with an interactive computer requires the performer to interact with the computer and intuitively and consciously include this information in the responsiveness of his playing. The interaction can...... be expanded to include the performer's high-level decisions typical of open-form notation. These decisions can be used for defining and re-defining the computer's role in further development of the piece. In this paper I describe how such an open-form notation is used in the interactive man....../machine performance environment of my composition 'GUITAR' for acoustic guitar and interactive computer. The performance environment functions as a perception-based multi-parameter space where the performer's score provides the means for exploring the space. The open-form notation emphazises the interactive...

  19. Open and Closed Form in Interactive Music

    DEFF Research Database (Denmark)

    Graugaard, Lars

    2005-01-01

    Performing music includes substantial listening skills on part of the performer. Performing with an interactive computer requires the performer to interact with the computer and intuitively and consciously include this information in the responsiveness of his playing. The interaction can be expan......Performing music includes substantial listening skills on part of the performer. Performing with an interactive computer requires the performer to interact with the computer and intuitively and consciously include this information in the responsiveness of his playing. The interaction can...... be expanded to include the performer's high-level decisions typical of open-form notation. These decisions can be used for defining and re-defining the computer's role in further development of the piece. In this paper I describe how such an open-form notation is used in the interactive man...

  20. Collaborative Web between open and closed science

    OpenAIRE

    2008-01-01

    “Web 2.0” is the mantra enthusiastically repeated in the past few years on anything concerning the production of culture, dialogue and online communication. Even science is changing, along with the processes involving the communication, collaboration and cooperation created through the web, yet rooted in some of its historical features of openness. For this issue, JCOM has asked some experts on the most recent changes in science to analyse the potential and the contradictions lying in online ...

  1. Fracture of open- and closed-cell metal foams

    NARCIS (Netherlands)

    Onck, P; van Merkerk, R.; Raaijmakers, A; De Hosson, JTM

    2005-01-01

    Two closed cell aluminium foams and one open cell nickel-chromium foam were subjected to microstructural characterization, in situ fracture tests and fractography. The failure process of the open cell foam was observed to be rather ductile, while that of the closed cell foams was found to be brittle

  2. Fracture of open- and closed-cell metal foams

    NARCIS (Netherlands)

    Onck, P; van Merkerk, R.; Raaijmakers, A; De Hosson, JTM

    2005-01-01

    Two closed cell aluminium foams and one open cell nickel-chromium foam were subjected to microstructural characterization, in situ fracture tests and fractography. The failure process of the open cell foam was observed to be rather ductile, while that of the closed cell foams was found to be

  3. Low luminance/eyes closed and monochromatic stimulations reduce variability of flash visual evoked potential latency

    Directory of Open Access Journals (Sweden)

    Senthil Kumar Subramanian

    2013-01-01

    Full Text Available Context: Visual evoked potentials are useful in investigating the physiology and pathophysiology of the human visual system. Flash visual evoked potential (FVEP, though technically easier, has less clinical utility because it shows great variations in both latency and amplitude for normal subjects. Aim: To study the effect of eye closure, low luminance, and monochromatic stimulation on the variability of FVEPs. Subjects and Methods: Subjects in self-reported good health in the age group of 18-30 years were divided into three groups. All participants underwent FVEP recording with eyes open and with white light at 0.6 J luminance (standard technique. Next recording was done in group 1 with closed eyes, group 2 with 1.2 and 20 J luminance, and group 3 with red and blue lights, while keeping all the other parameters constant. Two trials were given for each eye, for each technique. The same procedure was repeated at the same clock time on the following day. Statistical Analysis: Variation in FVEP latencies between the individuals (interindividual variability and the variations within the same individual for four trials (intraindividual variability were assessed using coefficient of variance (COV. The technique with lower COV was considered the better method. Results: Recording done with closed eyes, 0.6 J luminance, and monochromatic light (blue > red showed lower interindividual and intraindividual variability in P2 and N2 as compared to standard techniques. Conclusions: Low luminance flash stimulations and monochromatic light will reduce FVEP latency variability and may be clinically useful modifications of FVEP recording technique.

  4. Effect of Low-Level Laser Stimulation on EEG Power in Normal Subjects with Closed Eyes

    Directory of Open Access Journals (Sweden)

    Jih-Huah Wu

    2013-01-01

    Full Text Available In a previous study, we found that the low-level laser (LLL stimulation at the palm with a frequency of 10 Hz was able to induce significant brain activation in normal subjects with opened eyes. However, the electroencephalography (EEG changes to LLL stimulation in subjects with closed eyes have not been studied. In the present study, the laser array stimulator was applied to deliver insensible laser stimulations to the palm of the tested subjects with closed eyes (the laser group. The EEG activities before, during, and after the laser stimulation were collected. The EEG amplitude powers of each EEG frequency band at 19 locations were calculated. These power data were then analyzed by SPSS software using repeated-measure ANOVAs and appropriate posthoc tests. We found a pronounced decrease in the EEG power in alpha-bandwidth during laser simulation and then less decrease in the EEG power in delta-bandwidth in normal subjects with laser stimulation. The EEG power in beta-bandwidth in the right occipital area also decreased significantly in the laser group. We suggest that LLL stimulation might be conducive to falling into sleep in patients with sleep problems.

  5. Sparsification of Neuronal Activity in the Visual Cortex at Eye-Opening

    National Research Council Canada - National Science Library

    Nathalie L. Rochefort; Olga Garaschuk; Ruxandra-Lulia Milos; Madoka Narushima; Nima Marandi; Bruno Pichler; Yury Kovalchuk; Arthur Konnerth; Bert Sakmann

    2009-01-01

    Eye-opening represents a turning point in thè function of the visual cortex. Before eye-opening, the visual cortex is largely devoid of sensory inputs and neuronal activities are generated intrinsically...

  6. Prognostic indicators for no light perception after open-globe injury: eye injury vitrectomy study.

    Science.gov (United States)

    Feng, Kang; Hu, Yun Tao; Ma, Zhizhong

    2011-10-01

    To describe ocular characteristics, surgical interventions, and anatomic and visual outcomes of traumatized eyes with no light perception (NLP) following open-globe injury and to investigate prognostic predictors for NLP cases after open-globe injury. Interventional case series study. Thirty-three traumatized eyes with NLP were selected from the Eye Injury Vitrectomy Study database, a hospital-based multicenter prospective cohort study. Inclusion criteria were NLP cases following open-globe injury with outcomes of anatomic restoration, phthisis bulbi, or enucleation. Exclusion criteria were cases with missing records, undergoing vitrectomy after injury at nonparticipating hospitals, direct optic head injury, endophthalmitis, and hypotonous or silicone oil-sustained eyes. All cases underwent vitreoretinal surgery or enucleation after exploratory surgery and were followed up for at least 6 months. Two outcomes were assessed: favorable outcome (anatomically restored eye globes with light perception [LP] or better vision) and unfavorable outcome (NLP, phthisis bulbi, or enucleation). The following 7 risk factors were significant between the 2 groups: rupture (P = .021); open globe III (P = .046); scleral wound ≥10 mm (P = .001); ciliary body damage (P < .001); severe intraocular hemorrhage (P = .005); closed funnel retinal detachment or retinal prolapse (P = .005); and choroidal damage (P = .001). These 7 risk factors are possible predictors of poor prognosis. Traumatized eyes with NLP can be anatomically restored with LP or better vision if vitreoretinal surgery is attempted, and a favorable anatomic and visual outcome is increased by having a decreased number of these risk factors. Copyright © 2011 Elsevier Inc. All rights reserved.

  7. Random walks of cytoskeletal motors in open and closed compartments

    NARCIS (Netherlands)

    Lipowsky, R.; Klumpp, S.

    2001-01-01

    Random walks of molecular motors, which bind to and unbind from cytoskeletal filaments, are studied theoretically. The bound and unbound motors undergo directed and nondirected motion, respectively. Motors in open compartments exhibit anomalous drift velocities. Motors in closed compartments generat

  8. Learning to Control Opening and Closing a Myoelectric Hand

    OpenAIRE

    2010-01-01

    Bouwsema H, van der Sluis CK, Bongers RM. Learning to control opening and closing a myoelectric hand. Arch Phys Med Rehabil 2010;91:1442-6. Objective: To compare 3 different types of myoelectric signal training. Design: A cohort analytic study. Setting: University laboratory. Participants: Able-bodied right-handed participants (N=34) randomly assigned to 1 of 3 groups. Interventions: Participants trained hand opening and closing on 3 consecutive days. One group trained with a virtual myoelect...

  9. Inference in {open_quotes}poor{close_quotes} languages

    Energy Technology Data Exchange (ETDEWEB)

    Petrov, S. [Oak Ridge National Lab., TN (United States)

    1996-12-31

    Languages with a solvable implication problem but without complete and consistent systems of inference rules ({open_quote}poor{close_quote} languages) are considered. The problem of existence of a finite, complete, and consistent inference rule system for a {open_quotes}poor{close_quotes} language is stated independently of the language or the rule syntax. Several properties of the problem are proved. An application of the results to the language of join dependencies is given.

  10. Slow mode shocks propagating in open and closed magnetic fields

    Institute of Scientific and Technical Information of China (English)

    吕建永; 魏奉思

    1999-01-01

    A 2-D MHD model is used to investigate the propagation of slow mode shocks in the open and closed magnetic fields of the meridional plane near the sun. The solutions demonstrate that a forward slow shock could retain its slow shock characteristics into interplanetary space in the magnetically open region; however, it can evolve into an intermediate shock through the helmet-type current sheet to the open magnetic field.

  11. Closing open SDL-systems for model checking with DTSpin

    NARCIS (Netherlands)

    Ioustinova, N.; Sidorova, N.; Steffen, M.

    2002-01-01

    Model checkers like Spin can handle closed reactive systems, only. Thus to handle open systems, in particular when using assume-guarantee reasoning, we need to be able to close (sub-)systems, which is commonly done by adding an environment process. For models with asynchronous message-passing commun

  12. Comparative study of final visual outcome between open- and closed-globe injuries following surgical treatment of traumatic cataract.

    Science.gov (United States)

    Shah, Mehul Ashvin; Shah, Shreya Mehul; Shah, Shashank B; Patel, Chintan G; Patel, Utsav A; Appleware, Adway; Gupta, Ashish

    2011-12-01

    The objective of this work is to compare final visual outcomes in cases of surgically treated traumatic cataract between open-globe and closed-globe groups, as classified by the Birmingham Eye Trauma Terminology system. Observational cohort study. Tertiary eye-care center at the trijunction of Gujarat, Madhya Pradesh, and Rajasthan states in central western India. We enrolled patients meeting specific inclusion criteria, examined their eyes to review any co-morbidities due to trauma, performed surgery for traumatic cataracts, and implanted lenses. The patients were re-examined 6 weeks postoperatively. We classified the cases of traumatic cataract as either open-globe (group 1) or closed-globe (group 2), according to the Birmingham Eye Trauma Terminology (BETT) system, and compared visual acuity. Visual Acuity. Our cohort of 687 eyes with traumatic cataracts included 496 eyes in group 1 and 191 in group 2. Six weeks postoperatively, the visual acuity was >20/60 in 298 (58%) and 75 (39.1%) operated eyes in groups 1 and 2, respectively (p 20/60 vision was significantly higher in group 1 than in group 2 (OR = 1.61; 95% CI, 0.85-3.02). Overall, 373 eyes (54.3%) regained final visual acuity >20/60. Open-globe injury has a more favorable prognosis for satisfactory (>20/60) visual recovery after management of traumatic cataracts.

  13. Moving droplets between closed and open microfluidic systems.

    Science.gov (United States)

    Wang, Weiqiang; Jones, Thomas B

    2015-05-21

    In electric-field-mediated droplet microfluidics, there are two distinct architectures - closed systems using parallel-plate electrodes and open systems using coplanar electrodes fabricated on an open substrate. An architecture combining both closed and open systems on a chip would facilitate many of the chemical and biological processes now envisioned for the laboratory on a chip. To accomplish such an integration requires a means to move droplets back and forth between the two. This paper presents an investigation of the requirements for such manipulation of both water and oil droplets. The required wetting conditions for a droplet to cross the open/closed boundary is revealed by a force balance analysis and predictions of this model are compared to experimental results. Water droplets can be moved between closed and open systems by electrowetting actuation; droplet detachment from the upper plate is facilitated by the use of beveled edge. The force model predicts that driving an oil droplet from a closed to an open structure requires an oleophobic surface. This prediction has been tested and confirmed using silicon wafers made oleophobic by re-entrant microstructures etched into the surface.

  14. Closed Open Innovation’ or ‘Openly Closed Innovation’ – Which way is for world-first innovations?

    DEFF Research Database (Denmark)

    Li-Ying, Jason

    2014-01-01

    Open innovation’ strategy suggests the purposive use of knowledge inflows and outflows to accelerate internal innovation, and expand the markets for external use of innovation. The literature on ‘open innovation’ tends to agree that there are two dimensions of R&D projects can be used to evaluate...... were positively associated with the likelihood of an innovation being worldfirst; meanwhile, the findings reveal an overall trend that innovation modes for world-first innovation had become less and less closed and a mix of open modes had become equally effective as the closed ones....

  15. Walk on Floor Eyes Closed Test as a Measure of Postflight Ataxia

    Science.gov (United States)

    Reschke, M. F.; Fisher, E. A.; Kofman, I. S.; Cerisano, J. M.; Harm, D.L.; Peters, B. T.; Bloomberg, J. J.

    2010-01-01

    INTRODUCTION: Astronauts returning from space flight universally exhibit impaired posture and locomotion. Measurement of this impairment is an evolving process. The walk on the floor line test with the eyes closed (WOFEC) provides a unique procedure for quantifying postflight ataxia. Data from a modified WOFEC were obtained as part of an ongoing NASA interdisciplinary pre- and postflight study (Functional Task Test, FTT) designed to evaluate astronaut postflight functional performance. METHODS: Seven astronauts (5 short duration with flights of 12-16 days; 2 long duration crewmembers with flights of 6 months) were tested twice before flight, on landing day (short duration only), and 1, 6, and 30 days after flight. The WOFEC consisted of walking for 10 steps (repeated twice) with the feet heel to toe in tandem, arms folded across the chest and the eyes closed. The performance metric (scored by three examiners from video) was the percentage of correct steps completed over the three trials. A step was not counted as correct if the crewmember sidestepped, opened their eyes, or paused for more than three seconds between steps. RESULTS/ CONCLUSIONS: There was a significant decrease in percentage of correct steps on landing day (short duration crew) and on first day following landing (long duration) with partial recovery the following day, and full recovery beginning on day sixth after flight. Both short and long duration fliers appeared to be unaware of foot position relative to their bodies or the floor. Postflight, deviation from a straight path was common, and the test for two crewmembers elicited motion sickness symptoms. These data clearly demonstrate the sensorimotor challenges facing crewmembers after returning from spaceflight. The WOFEC test has value providing the investigator or crew surgeon with a simple method to quantify vestibular ataxia, as well as providing instant feedback of postural ataxia without the use of complex test equipment.

  16. SOFIA Closed- and Open-Door Aerodynamic Analyses

    Science.gov (United States)

    Cumming, Stephen; Frederick, Mike; Smith, Mark

    2012-01-01

    Work to evaluate the aerodynamic characteristics and the cavity acoustic environment of the SOFIA (Stratospheric Observatory for Infrared Astronomy) airplane has been completed. The airplane has been evaluated in its closed-door configuration, as well as several open-door configurations. Work performed included: acoustic analysis tool development, cavity acoustic evaluation, stability and control parameter estimation, air data calibration, and external flow evaluation. Qualitative airflow data were obtained during the closed- and open-door flights using tufts on the aft portion of the fuselage. Video was taken from a chase plane. This video was analyzed for various flight conditions, and general flow descriptions of the aft fuselage of the 747SP were developed for the different closed and open door configurations.

  17. Open vs Closed Access Femtocells in the Uplink

    CERN Document Server

    Xia, Ping; Andrews, Jeffrey G

    2010-01-01

    Femtocells are assuming an increasingly important role in the coverage and capacity of cellular networks. In contrast to existing cellular systems, femtocells are end-user deployed and controlled, randomly located, and rely on third party backhaul (e.g. DSL or cable modem). Femtocells can be configured to be either open access or closed access. Open access allows an arbitrary nearby cellular user to use the femtocell, whereas closed access restricts the use of the femtocell to users explicitly approved by the owner. Seemingly, the network operator would prefer an open access deployment since this provides an inexpensive way to expand their network capabilities, whereas the femtocell owner would prefer closed access, in order to keep the femtocell's capacity and backhaul to himself. We show mathematically and through simulations that the reality is more complicated for both parties, and that the best approach depends heavily on whether the multiple access scheme is orthogonal (TDMA or OFDMA, per subband) or no...

  18. Closed Graph and Open Mapping Theorems for Normed Cones

    Indian Academy of Sciences (India)

    Oscar Valero

    2008-05-01

    A quasi-normed cone is a pair (, ) such that is a (not necessarily cancellative) cone and is a quasi-norm on . The aim of this paper is to prove a closed graph and an open mapping type theorem for quasi-normed cones. This is done with the help of appropriate notions of completeness, continuity and openness that arise in a natural way from the setting of bitopological spaces.

  19. The {open_quotes}first{close_quotes} problem

    Energy Technology Data Exchange (ETDEWEB)

    Holsinger, R.F.

    1995-02-01

    This paper describes the first magnet design problem that Klaus and the author worked on together. At the time, over 30 years ago, Klaus was working as a plasma physicist in the Controlled Thermonuclear Research (CTR) Group, and the author was assigned from the Mechanical Engineering Department to help with the design of experimental equipment for various research projects. Klaus` primary research program was to develop a {open_quotes}plasma gun{close_quotes} for injecting plasma into {open_quotes}mirror machines.{close_quotes} As described, the magnet design aspect of this plasma gun was a challenging task, and led to some innovations that were quite advanced at that time.

  20. Learning to Control Opening and Closing a Myoelectric Hand

    NARCIS (Netherlands)

    Bouwsema, Hanneke; van der Sluis, Corry K.; Bongers, Raoul M.

    2010-01-01

    Bouwsema H, van der Sluis CK, Bongers RM. Learning to control opening and closing a myoelectric hand. Arch Phys Med Rehabil 2010;91:1442-6. Objective: To compare 3 different types of myoelectric signal training. Design: A cohort analytic study. Setting: University laboratory. Participants: Able-bodi

  1. Cooperative transition between open and closed conformations in potassium channels.

    Directory of Open Access Journals (Sweden)

    Turkan Haliloglu

    Full Text Available Potassium (K+ ion channels switch between open and closed conformations. The nature of this important transition was revealed by comparing the X-ray crystal structures of the MthK channel from Methanobacterium thermoautotrophicum, obtained in its open conformation, and the KcsA channel from Streptomyces lividans, obtained in its closed conformation. We analyzed the dynamic characteristics and energetics of these homotetrameric structures in order to study the role of the intersubunit cooperativity in this transition. For this, elastic models and in silico alanine-scanning mutagenesis were used, respectively. Reassuringly, the calculations manifested motion from the open (closed towards the closed (open conformation. The calculations also revealed a network of dynamically and energetically coupled residues. Interestingly, the network suggests coupling between the selectivity filter and the gate, which are located at the two ends of the channel pore. Coupling between these two regions was not observed in calculations that were conducted with the monomer, which emphasizes the importance of the intersubunit interactions within the tetrameric structure for the cooperative gating behavior of the channel.

  2. Deciphering the evolutionary history of open and closed mitosis.

    Science.gov (United States)

    Sazer, Shelley; Lynch, Michael; Needleman, Daniel

    2014-11-17

    The origin of the nucleus at the prokaryote-to-eukaryote transition represents one of the most important events in the evolution of cellular organization. The nuclear envelope encircles the chromosomes in interphase and is a selectively permeable barrier between the nucleoplasm and cytoplasm and an organizational scaffold for the nucleus. It remains intact in the 'closed' mitosis of some yeasts, but loses its integrity in the 'open' mitosis of mammals. Instances of both types of mitosis within two evolutionary clades indicate multiple evolutionary transitions between open and closed mitosis, although the underlying genetic changes that influenced these transitions remain unknown. A survey of the diversity of mitotic nuclei that fall between these extremes is the starting point from which to determine the physiologically relevant characteristics distinguishing open from closed mitosis and to understand how they evolved and why they are retained in present-day organisms. The field is now poised to begin addressing these issues by defining and documenting patterns of mitotic nuclear variation within and among species and mapping them onto a phylogenic tree. Deciphering the evolutionary history of open and closed mitosis will complement cell biological and genetic approaches aimed at deciphering the fundamental organizational principles of the nucleus.

  3. Segmented ball valve is easy to open and close

    Science.gov (United States)

    Prono, E.; Shinault, L. H.; Speisman, C.

    1966-01-01

    Segmented ball valve and flowmeter in the same spherical housing provide a valve that will handle large fluid volume without bulkiness and weight of blade valves or conventional ball valves. The valve is easily opened or closed and the flowmeter remains stationary, so errors are eliminated.

  4. Case-control study of risk factors for no light perception after open-globe injury: eye injury vitrectomy study.

    Science.gov (United States)

    Feng, Kang; Shen, Lijun; Pang, Xiuqin; Jiang, Yanrong; Nie, Hongping; Wang, Zhijun; Hu, Yuntao; Ma, Zhizhong

    2011-11-01

    Investigate possible risk factors of no light perception (NLP) after open-globe injury. Explore whether these risk factors are predictors for an unfavorable visual outcome. This case-control study matched 72 eyes with NLP according to type and zone of injury to 2 controls per case with light perception or better vision. Cases were selected from the Eye Injury Vitrectomy Study database. All injured eyes in the study underwent surgical intervention. Ciliary body damage (odds ratio = 2.94), closed funnel retinal detachment (odds ratio = 2.43), and choroidal damage (odds ratio = 2.80) were independent risk factors for NLP after open-globe injury. There were 67 traumatized eyes with NLP that had ≥1 of these risk factors. In 43 of the cases (64.2%), the eyes recovered light perception or better after vitreoretinal surgery. The five traumatized NLP cases without these risk factors obtained a favorable visual outcome after vitreoretinal surgery. There was no statistical significance in visual outcome between them (P = 0.162). Ciliary body damage, closed funnel retinal detachment, and choroidal damage are independent risk factors for NLP posttrauma but not prognostic indicators for NLP visual outcome. Traumatized eyes with NLP may recover light perception or better vision if appropriate interventional measures are used for treatment of the injured ciliary body, retina, and choroid.

  5. Study of the Open Loop and Closed Loop Oscillator Techniques

    Energy Technology Data Exchange (ETDEWEB)

    Imel, George R. [Idaho State Univ., Pocatello, ID (United States); Baker, Benjamin [Idaho National Lab. (INL), Idaho Falls, ID (United States); Riley, Tony [Knolls Atomic Power Lab. (KAPL), Schenectady, NY (United States); Langbehn, Adam [Puget Sound Naval Base, Bremerton, WA (United States); Aryal, Harishchandra [Idaho State Univ., Pocatello, ID (United States); Benzerga, M. Lamine [Idaho State Univ., Pocatello, ID (United States)

    2015-04-11

    This report presents the progress and completion of a five-year study undertaken at Idaho State University of the measurement of very small worth reactivity samples comparing open and closed loop oscillator techniques.The study conclusively demonstrated the equivalency of the two techniques with regard to uncertainties in reactivity values, i.e., limited by reactor noise. As those results are thoroughly documented in recent publications, in this report we will concentrate on the support work that was necessary. For example, we describe in some detail the construction and calibration of a pilot rod for the closed loop system. We discuss the campaign to measure the required reactor parameters necessary for inverse-kinetics. Finally, we briefly discuss the transfer of the open loop technique to other reactor systems.

  6. Detecting quantum speedup in closed and open systems

    Science.gov (United States)

    Xu, Zhen-Yu

    2016-07-01

    We construct a general measure for detecting the quantum speedup in both closed and open systems. The speed measure is based on the changing rate of the position of quantum states on a manifold with appropriate monotone Riemannian metrics. Any increase in speed is a clear signature of dynamical speedup. To clarify the mechanisms for quantum speedup, we first introduce the concept of longitudinal and transverse types of speedup: the former stems from the time evolution process itself with fixed initial conditions, while the latter is a result of adjusting initial conditions. We then apply the proposed measure to several typical closed and open quantum systems, illustrating that quantum coherence (or entanglement) and the memory effect of the environment together can become resources for longitudinally or transversely accelerating dynamical evolution under specific conditions and assumptions.

  7. Measure of the Quantum Speedup in Closed and Open systems

    Science.gov (United States)

    Xu, Zhen-Yu

    We construct a general measure for detecting the quantum speedup in both closed and open systems. This speed measure is based on the changing rate of the position of quantum states on a manifold with appropriate monotone Riemannian metrics. Any increase in speed is a clear signature of real dynamical speedup. To clarify the mechanisms of quantum speedup, we first introduce the concept of longitudinal and transverse types of speedup, and then apply the proposed measure to several typical closed and open quantum systems, illustrating that entanglement and the memory effect of the environment together can become resources for longitudinally or transversely accelerating dynamical evolution under certain conditions. Remarkably, a direct measurement of such speedup is feasible without the need for a tomographic reconstruction of the density matrix, which greatly enhances the feasibility of practical experimental tests. This work was supported by the National Natural Science Foundation of China (Grant No. 11204196).

  8. An open plus nonlinear closed loop control of chaotic oscillators

    Institute of Scientific and Technical Information of China (English)

    陈立群

    2002-01-01

    An open plus nonlinear closed loop control law is presented for chaotic oscillations described by a set of non-autonomous second-order ordinary differential equations. It is proven that the basins of entrainment are global whenthe right-hand sides of the equations are given by arbitrary polynomial functions. The forced Duffing oscillator and theforced van der Pol oscillator are treated as numerical examples to demonstrate the applications of the method.

  9. Factorization Conjecture and the Open/Closed String Correspondence

    CERN Document Server

    Baumgartl, M; Shatashvili, S L; Baumgartl, Marcus; Sachs, Ivo; Shatashvili, Samson L.

    2005-01-01

    We present evidence for the factorization of the world-sheet path integrals for 2d conformal field theories on the disk into bulk and boundary contributions. This factorization is then used to reinterpret a shift in closed string backgrounds in terms of boundary deformations in background independent open string field theory. We give a proof of the factorization conjecture in the cases where the background is represented by WZW and related models.

  10. Opening- and Closing-Wedge Distal Femoral Osteotomy

    Science.gov (United States)

    Chahla, Jorge; Mitchell, Justin J.; Liechti, Daniel J.; Moatshe, Gilbert; Menge, Travis J.; Dean, Chase S.; LaPrade, Robert F.

    2016-01-01

    Background: Lateral compartment osteoarthritis of the knee can be a challenging pathology in the younger, active population due to limited treatment options and high patient expectations. Distal femoral osteotomy (DFO) has been reported to be a potential treatment option. Purpose: To perform a systematic review on the survival, outcomes, and complications of DFO for treatment of genu valgum with concomitant lateral compartment osteoarthritis of the knee. Study Design: Systematic review; Level of evidence, 4. Methods: A systematic review of the literature was performed using the Cochrane Database of Systematic Reviews, the Cochrane Central Registry of Controlled Trials, PubMed, and MEDLINE from 1980 to present. Inclusion criteria were as follows: outcomes of opening- and closing-wedge DFOs performed for treatment of genu valgum with concomitant lateral compartment osteoarthritis of the knee, English language, minimum 2-year follow-up, and human studies. Data abstracted from the selected studies included type of osteotomy (opening vs closing), survival rate, patient-reported and radiographic outcomes, and complications. Results: Fourteen studies met the inclusion criteria and were considered for the review. A total of 9 closing-wedge and 5 opening-wedge DFO studies were included. All were retrospective studies and reported good to excellent patient-reported outcomes after DFO. Survival decreased with increasing time from surgery, with 1 study reporting a 100% survival rate at 6.5 years, compared with 21.5% at 20 years in another study. A low rate of complications was reported throughout the review. Conclusion: Highly heterogeneous literature exists for both opening- and closing-wedge DFOs for the treatment of isolated lateral compartment osteoarthritis with valgus malalignment. A mean survival rate of 80% at 10-year follow-up was reported, supporting that this procedure can be a viable treatment option to delay or reduce the need for joint arthroplasty. A low

  11. Electromagnetically driven, fast opening and closing gas jet valve

    Science.gov (United States)

    Krishnan, Mahadevan; Elliott, Kristi Wilson; Geddes, C. G. R.; van Mourik, R. A.; Leemans, W. P.; Murphy, H.; Clover, M.

    2011-03-01

    The design and performance are presented of an electromagnetically driven gas valve [M. Krishnan, J. Wright, and T. Ma, Proceedings of the 13th Advanced Accelerator Concepts Workshop, Santa Cruz, CA, AIP Conf. Proc. No. 1086 (AIP, New York, 2008)] that opens in <100μs, closes in <500μs, and can operate at pressures of ˜1000psia to drive supersonic nozzles. Such a valve has applications to laser-plasma accelerators, where the fast opening and closing would allow sharper edges to the flow and also allow higher rep-rate operation without loading the vacuum chamber. The valve action is effected by a flyer plate accelerated by the electromagnetic impulse of a low inductance, spiral wound, strip-line coil driven by a capacitor. Gas flows out of the valve when the seal between this flyer plate and the valve seat is broken. The electromagnetic force greatly exceeds the restoring forces provided by a spring and the gas pressure against the valve seat. Piezoresistive sensor and laser interferometer measurements of flow show that the valve opens in ˜100μs for all pressures up to 800 psia. The closing time is 500μs, set by the spring constant and mass. The prototype valve has been operated with helium at 0.5 Hz and at 500 psia for ˜1 hour at a time with no cooling.

  12. Closed string amplitudes as single-valued open string amplitudes

    Energy Technology Data Exchange (ETDEWEB)

    Stieberger, Stephan, E-mail: stephan.stieberger@mpp.mpg.de [Max-Planck-Institut für Physik, Werner-Heisenberg-Institut, 80805 München (Germany); Taylor, Tomasz R. [Department of Physics, Northeastern University, Boston, MA 02115 (United States)

    2014-04-15

    We show that the single trace heterotic N-point tree-level gauge amplitude A{sub N}{sup HET} can be obtained from the corresponding type I amplitude A{sub N}{sup I} by the single-valued (sv) projection: A{sub N}{sup HET}=sv(A{sub N}{sup I}). This projection maps multiple zeta values to single-valued multiple zeta values. The latter represent a subclass of multiple zeta values originating from single-valued multiple polylogarithms at unity. Similar relations between open and closed string amplitudes or amplitudes of different string vacua can be established. As a consequence the α{sup ′}-expansion of a closed string amplitude is dictated by that of the corresponding open string amplitude. The combination of single-valued projections, Kawai–Lewellen–Tye relations and Mellin correspondence reveal a unity of all tree-level open and closed superstring amplitudes together with the maximally supersymmetric Yang–Mills and supergravity theories.

  13. Walk on Floor Eyes Closed Test: A Unique Test of Spaceflight Induced Ataxia

    Science.gov (United States)

    Reschke, M. F.; Fisher, E. A.; Kofman, I. S.; Cerisano, J. M.; Harm, D. L.; Bloomberg, J. J.

    2011-01-01

    Measurement and quantification of posture and locomotion following spaceflight is an evolving process. Based on the data obtained from the current investigation we believe that the walk on the floor line test with the eyes closed (WOFEC) provides a unique procedure for quantifying postflight ataxia. As a part of an ongoing investigation designed to look at functional changes in astronauts returning from spaceflight seven astronauts (5 short duration with flights of 12-16 days; 2 long duration crewmembers with flights of 6 months) were tested twice before flight, on landing day (short duration only), and 1, 6, and 30 days after flight. The WOFEC consisted of walking for 10 steps (repeated twice) with the feet heel to toe in tandem, arms folded across the chest and the eyes closed. The performance metric (scored by three examiners from video) was the percentage of correct steps completed over the three trials. A step was not counted as correct if the crewmember side-stepped, opened their eyes, or paused for more than three seconds between steps. The data reveled a significant decrease in percentage of correct steps on landing day (short duration crew) and on the first day following landing (long duration) with partial recovery the following day, and full recovery beginning on day sixth after flight. Both short and long duration fliers appeared to be unaware of foot position relative to their bodies or the floor. Postflight, deviation from a straight path was common, and seemed to be determined by the angle of foot placement relative to their body. While deviation from a straight line could be either left or right, primary deviations were observed to occur to the right. Furthermore, the test for two crewmembers elicited motion sickness symptoms. These data clearly demonstrate the sensorimotor challenges facing crewmembers after returning from spaceflight. The WOFEC test has value providing the investigator or crew surgeon with a simple method to quantify vestibular

  14. Open/closed string duality and relativistic fluids

    Science.gov (United States)

    Niarchos, Vasilis

    2016-07-01

    We propose an open/closed string duality in general backgrounds extending previous ideas about open string completeness by Ashoke Sen. Our proposal sets up a general version of holography that works in gravity as a tomographic principle. We argue, in particular, that previous expectations of a supergravity/Dirac-Born-Infeld (DBI) correspondence are naturally embedded in this conjecture and can be tested in a well-defined manner. As an example, we consider the correspondence between open string field theories on extremal D-brane setups in flat space in the large-N , large 't Hooft limit, and asymptotically flat solutions in ten-dimensional type II supergravity. We focus on a convenient long-wavelength regime, where specific effects of higher-spin open string modes can be traced explicitly in the dual supergravity computation. For instance, in this regime we show how the full Abelian DBI action arises from supergravity as a straightforward reformulation of relativistic hydrodynamics. In the example of a (2 +1 )-dimensional open string theory this reformulation involves an Abelian Hodge duality. We also point out how different deformations of the DBI action, related to higher-derivative corrections and non-Abelian effects, can arise in this context as deformations in corresponding relativistic hydrodynamics.

  15. EnKF with closed-eye period - towards a consistent aggregation of information in soil hydrology

    Science.gov (United States)

    Bauser, Hannes H.; Jaumann, Stefan; Berg, Daniel; Roth, Kurt

    2016-12-01

    The representation of soil water movement exposes uncertainties in all model components. We assess the key uncertainties for the specific hydraulic situation of a 1-D soil profile with TDR (time domain reflectometry)-measured water contents. The uncertainties addressed are initial condition, soil hydraulic parameters, small-scale heterogeneity, upper boundary condition, and the local equilibrium assumption by the Richards equation. We employ an ensemble Kalman filter (EnKF) with an augmented state to represent and estimate all key uncertainties, except for the intermittent violation of the local equilibrium assumption. For the latter, we introduce a closed-eye EnKF to bridge the gap. Due to an iterative approach, the EnKF was capable of estimating soil parameters, Miller scaling factors and upper boundary condition based on TDR measurements during a single rain event. The introduced closed-eye period ensured constant parameters, suggesting that they resemble the believed true material properties. This closed-eye period improves predictions during periods when the local equilibrium assumption is met, but requires a description of the dynamics during local non-equilibrium phases to be able to predict them. Such a description remains an open challenge. Finally, for the given representation our results show the necessity of including small-scale heterogeneity. A simplified representation with Miller scaling already yielded a satisfactory description.

  16. Recultivation of the cavity of the closed open pit Bor

    Directory of Open Access Journals (Sweden)

    Lilić Jasmina

    2008-01-01

    Full Text Available Copper ore is one of the most important raw materials for industrial production. Increasing demands have been increasing its extraction generally. Shallow deposits with higher copper grade are mostly exhausted and the open pits become deeper, also the amount of overburden and the problems of its disposal are increased. In some cases large quantities of overburden can solve the problem of recultivation of degraded areas. This is the case of recultivation of degraded areas on the location of the closed open pit Bor. Here, the overburden from another open pit, Veliki Krivelj, is disposed into the cavity of the open pit Bor. In this way the overburden is disposed without further area degradation and the cavity is primarily, technically recultivated. When the filling process is finished, waste depot will have a flat top at the level K+450 [2], which is above the neighboring terrain, and the slopes height will vary. This problem was not especially considered up to date, so the experiences in this field are humble. This paper intends to be the basis for further research.

  17. Open/closed string duality and relativistic fluids

    CERN Document Server

    Niarchos, Vasilis

    2015-01-01

    We propose an open/closed string duality in general backgrounds extending previous ideas about open string completeness by Ashoke Sen. Our proposal sets up a general version of holography that works in gravity as a tomographic principle. We argue, in particular, that previous expectations of a supergravity/Dirac-Born-Infeld (DBI) correspondence are naturally embedded in this conjecture and can be tested in a well-defined manner. As an example, we consider the correspondence between open string field theories on extremal D-brane setups in flat space in the large-N, large 't Hooft limit, and asymptotically flat solutions in ten-dimensional type II supergravity. We focus on a convenient long-wavelength regime, where specific effects of higher-spin open string modes can be traced explicitly in the dual supergravity computation. For instance, in this regime we show how the full abelian DBI action arises from supergravity as a straightforward reformulation of relativistic hydrodynamics. In the example of a (2+1)-di...

  18. Closed chamber pupilloplasty with an injectable shape memory alloy clip in enucleated porcine eyes in the laboratory setting.

    Science.gov (United States)

    Erlanger, Michael S; Olson, Jeffrey L

    2012-01-01

    A novel surgical technique and novel surgical instrumentation for closing a pupil defect in a closed chamber eye is described. The technique was performed in a laboratory setting using ex-vivo porcine eyes using a 30-gauge deployment system to repair iris defects. Given the difficulty of suturing in a closed chamber eye, the use of an injectable, shape memory alloy clip offers the advantages of rapid, easy deployment and increased strength over conventional suture techniques.

  19. Static Balance of Visually Impaired Athletes in Open and Closed Skill Sports

    Directory of Open Access Journals (Sweden)

    Bednarczuk Grzegorz

    2017-03-01

    Full Text Available Introduction. In elite sport, athletes are required to maintain appropriate body posture control despite a number of destabilising factors. The functions of body posture control are monitored by the central nervous system that constantly receives information from the vestibular and somatosensory systems as well as from the visual analyser. Visual impairment may contribute to a decrease in the level of motor abilities and skills; however, it does not prevent visually impaired individuals from taking up physical activity. Therefore, this study sought to assess the static balance of visually impaired goalball players and shooters. Material and methods. The study included 37 goalball players and 20 shooters. A force platform was used to assess static balance. The study participants performed tests: standing on both feet with eyes open (BFEO and closed (BFEC (30 s, single left- and right-leg stance with eyes open (SLEO and SREO as well as single left- and right-leg stance with eyes closed (SLEC and SREC. Statistical analyses were carried out using the following parameters: centre of pressure (CoP path length [cm], CoP velocity [m/s], and the surface area of the stabilogram [cm2]. Results. No significant differences were found between goalball players and shooters in static balance levels. However, such differences were observed after taking into account the number of athletes who were capable of performing particular tests. Conclusions. The findings indirectly confirm that there is a correlation between the type of physical activity and balance levels in visually impaired individuals. Further research ought to include tests performed on an unstable surface.

  20. The Walk on Floor Eyes Closed Tandem Step Test as a Quantitative Measure of Ataxia After Space Flight

    Science.gov (United States)

    Fisher, E. A.; Reschke, M. F.; Kofman, I. S.; Cerisano, J. M.; Lawrence, E. L.; Peters, B. T.; Bloomberg, J. J.; Harm, D. L.

    2010-01-01

    INTRODUCTION Posture and locomotion are among the functions most affected by space flight. Postflight ataxia can be quantified easily by using the walk on the floor line test with the eyes closed (WOFEC). Data from a modified WOFEC were obtained as part of an ongoing interdisciplinary pre- and postflight study (Functional Task Test, FTT) designed to evaluate both postflight functional performance of astronauts and related physiological changes. METHODS Five astronauts with flight durations of 12 to 16 days participated in this study. Performance measurements were obtained in 2 preflight sessions, on landing day, and 1, 6, and 30 days after landing. The WOFEC test consisted of walking with the feet placed heel to toe in tandem, arms folded across the chest and eyes closed, for 10 steps. A trial was initiated after the eyes were closed and the front foot was aligned with the rear foot. The performance metric was the average percentage of correct steps completed over 3 trials. A step was not counted as correct if the crewmember sidestepped, opened eyes, or paused for more than 3 seconds between steps. Step accuracy was scored independently by 3 examiners. RESULTS Immediately after landing subjects seemed to be unaware of their foot position relative to their body or the floor. The percentage of correct steps was significantly decreased on landing day. Partial recovery was observed the next day, and full recovery to baseline on the sixth day post landing. CONCLUSION These data clearly demonstrate the sensorimotor challenges facing crewmembers after they return from space flight. Although this simple test is intended to complement the FTT battery of tests, it has some stand-alone value as it provides investigators with a means to quantify vestibular ataxia as well as provide instant feedback on postural stability without the use of complex test equipment.

  1. The French Socialist Party: Membership between Closed and Open Primaries

    Directory of Open Access Journals (Sweden)

    Marino De Luca

    2015-03-01

    Full Text Available For some years now the clamor for democratisation of parties' internal functioning has been spreading across democracies. Among them, France has advanced impressively in the past few years. In 2006, the Socialist Party (PS launched a closed primary to choose the socialist candidate, Ségolène Royal, for the 2007 presidential election. Approaching the 2012 presidential elections, the leftist coalition (PS and PRG launched open primary elections to select its chief-executive candidates, with François Hollande finally emerging as a nominee. In this article, we shall examine how the socialist membership changed during the past three socialist congresses, analysing the outcome of the two above-mentioned primary elections. In particular, we shall observe the Le Mans (2005, Reims (2008 and Toulouse (2012 Congresses, and describe membership, participation, and competitiveness within the PS. The study was based on data collected from an administrative unit, the French départements.

  2. Observation of EIA in closed and open caesium atomic system

    Institute of Scientific and Technical Information of China (English)

    Zhao Jian-Ming; Zhao Yan-Ting; Huang Tao; Xiao Lian-Tuan; Jia Suo-Tang

    2005-01-01

    We present an experimental study on electromagnetically induced absorption (EIA) in the closed transition of a degenerate two-level Cs atomic system. The coupling and probe lasers coupled with the transition 6S1/2F=4 →6P3/2F'=5 of caesium atom. The signal of EIA was obtained and the frequency detuning and intensity effect of the pumping laser were experimentally investigated. The EIA signal in 6S1/2 F=4 → 6P3/2 F'=4 and 6S1/2 F=4 → 6P3/2F'=3 open transitions was also obtained. As the repumping laser couples with the transition of 6S1/2 F=3 → 6P3/2F'=4, the EIA signal is increased due to the hyperfine optical pumping.

  3. Tundish Open Eye Formation in Inert Gas-Shrouded Tundishes: A Macroscopic Model from First Principles

    Science.gov (United States)

    Chatterjee, Saikat; Chattopadhyay, Kinnor

    2016-10-01

    Open eye formation in tundishes can result in reoxidation of liquid steel leading to the formation of harmful inclusions. Moreover, it is also a site for heat loss, gas absorption, and slag emulsification. All these factors make it necessary to understand the fundamentals of open eye formation, which in turn will allow us to prevent or control its harmful effects. In the present study, the bubble plume regions in a ladle and tundish were compared, and it was observed that there are significant differences between the two. Moreover, a simplistic model for predicting the open eye area in tundishes for `thin slag' practices was derived using the principles of conservation of mass and momentum. The proposed model was able to predict open eye areas in tundish reasonably well and was compared with other models, and experimental results.

  4. Layer-specific refinement of visual cortex function after eye opening in the awake mouse

    National Research Council Canada - National Science Library

    Hoy, Jennifer L; Niell, Cristopher M

    2015-01-01

    .... Here, we use multisite electrophysiological recording in the awake mouse across an extended period of development, starting at eye opening, to measure receptive field properties and behavioral-state...

  5. Cannabinoid-dependent potentiation of inhibition at eye opening in mouse V1

    National Research Council Canada - National Science Library

    Garkun, Yury; Maffei, Arianna

    2014-01-01

    .... Here we show that in the developmental window extending from eye opening to the onset of the critical period for visual cortical plasticity L4 inhibitory inputs onto pyramidal neurons are highly...

  6. Dynamic Air Route Open-Close Problem for Airspace Management

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    Dynamic airspace management plans and assigns airspace resources to airspace users on demand to increase airspace capacity. Although many studies of air traffic flow management (ATFM) have sought to optimally allocate air traffic to get the best use of given airspace resources, few studies have focused on how to build an efficient air traffic network or how to adjust the current network in real time. This paper presents an integer program model named the dynamic air route open-close problem (DROP). DROP has a cost-based objective function which takes into account constraints such as the shortest occupancy time of routes, which are not considered in ATFM models. The aim of DROP is to determine which routes will be opened to a certain user during a given time period. Simulation results show that DROP can facilitate utilization of air routes. DROP, a simplified version of an air traffic network constructing problem, is the first step towards realizing dynamic airspace management. The combination of ATFM and DROP can facilitate decisions toward more reasonable, efficient use of limited airspace resources.

  7. Theater and ALife Art: Modeling Open and Closed Systems.

    Science.gov (United States)

    Norman, Sally Jane

    2015-01-01

    The live art of theater remains curiously missing from ALife art history, despite the fact that its very existence is poised on the cusp of the living and the artificial, and on the modeling of life as artefact-what can be called the containment-versus-continuity dilemma. How far one seeks to affirm autonomy of the creative artwork or, in contrast, how far one seeks to affirm its continuity with its supposed real-life contexts is a question that has forever haunted theater, and that has naturally come to haunt ALife and ALife arts. Investigation of the boundary separating observers from modeled systems is as core to research into the live art of theater as to ALife research. This brief article seeks to open up discussion on links between ALife, ALife art, and the live art of theater, through key thematic threads that traverse these domains: their modeling of universes, the open or closed nature of the resultant modeled systems, and their implications with respect to observers, definitions, and instantiations of life regarding non-life or death as well as attributions of liveness to emergent synthetic biology and metamaterials.

  8. Closed And Open String Theories In Non-critical Backgrounds

    CERN Document Server

    Murthy, S

    2004-01-01

    This thesis is a study of closed and open string theories in low dimensional spacetimes, and the various relations between these theories. In particular, we focus on the theory of the two-dimensional black hole. We first study closed strings in the background of the Euclidean two-dimensional black hole (SL2( R )/U(1)) tensored with flat space, using the duality relating these theories to non-critical superstrings described by the supersymmetric sine-Liouville interaction on the worldsheet. We point out a subtlety in their geometric interpretation, and clarify the symmetry structure of the theories based on the understanding of these theories as near horizon limits of wrapped NS5-branes. In one such example (cigar × R6 ), we use the brave description to understand the enhancement of the global symmetry in the coset theory from U(1) to SO(3) under which the sine-Liouville and cigar interactions are related. In the same example, a worldsheet description of the moduli space R4/Z2 is presented. W...

  9. Invasion of lymphatic vessels into the eye after open globe injuries.

    Science.gov (United States)

    Wessel, Julia M; Hofmann-Rummelt, Carmen; Kruse, Friedrich E; Cursiefen, Claus; Heindl, Ludwig M

    2012-06-20

    We analyzed whether lymphatic vessels can be detected in eyes enucleated after an open globe injury. The presence of lymphatic vessels was analyzed immunohistochemically using podoplanin as a specific lymphatic endothelial marker in 21 globes that had been enucleated after open globe injury. The localization of pathologic lymphatic vessels (within the eye wall or inside the eye) was correlated with the mechanism of trauma, anatomic site of perforation or rupture, and time interval between trauma and enucleation. Pathologic lymphatic vessels were detected in 15 of 21 eyes (71%) enucleated after an open globe injury. In 5 globes (24%) they were found within the eye, located in retrocorneal membranes, underneath the sclera, and adjacent to uveal tissue (ciliary body, iris). No significant association was observed between the presence of pathologic lymphatic vessels and the mechanism of trauma (P = 0.598), anatomic site of perforation or rupture (P = 0.303), and time interval between trauma and enucleation (P = 0.145). The human eye can be invaded secondarily by lymphatic vessels if the eye wall is opened by trauma. This mechanism could be important for wound healing, immunologic defense against intruding microorganisms, and autoimmune reactions against intraocular antigens.

  10. Visual outcome after emergency surgery for open globe eye injury in Japan.

    Science.gov (United States)

    Toride, Ai; Toshida, Hiroshi; Matsui, Asaki; Matsuzaki, Yusuke; Honda, Rio; Ohta, Toshihiko; Murakami, Akira

    2016-01-01

    Most patients with open globe eye injury are brought to hospital as emergency patients and usually require admission for emergency surgery. We analyzed the visual outcome in patients with open globe eye injury at our hospital over a 4-year period. This study reviewed 40 eyes of 40 patients with open globe eye injury who were presented to Juntendo University Shizuoka Hospital and required emergency surgery during the 4 years from January 2010 to December 2014. Retrospective evaluation of the visual outcome was performed using data from the medical records, including assessment of the influence of sex, side of the eye injury, cause of injury, and site/severity of injury. The mean age (SD) at the time of the injury was 58.9 years (±25.1 years). There were 28 males (70.0%) and 12 females (30.0%). Statistically significant improvement in visual acuity after treatment was noted in the males (P=0.0015, Wilcoxon test), but not in the females. Twenty-five patients had injury to the right eye (62.5%) and 15 had injury to the left eye (37.5%). A significant improvement in visual acuity was achieved after treatment of injury to the right eye (P=0.021), but not the left eye (P=0.109). The most frequent cause of injury was an accident (15 eyes; 37.5%). The second most frequent cause was work-related injury (14 eyes; 35.0%), which only occurred in males, and the third cause was accident due to negligence (eleven eyes; 27.5%). Two patients developed sympathetic ophthalmia and one patient developed postoperative endophthalmitis. The majority of patients with open globe eye injury were male workers in Japan. The visual outcome of work-related injury was better than that of injury due to other causes. The visual outcome was also better if the right eye was injured compared with the left eye. Patients with injuries due to negligence were older than the other groups, and this finding might be characteristic of an aging society.

  11. Visual outcome after emergency surgery for open globe eye injury in Japan

    Science.gov (United States)

    Toride, Ai; Toshida, Hiroshi; Matsui, Asaki; Matsuzaki, Yusuke; Honda, Rio; Ohta, Toshihiko; Murakami, Akira

    2016-01-01

    Background Most patients with open globe eye injury are brought to hospital as emergency patients and usually require admission for emergency surgery. We analyzed the visual outcome in patients with open globe eye injury at our hospital over a 4-year period. Patients and methods This study reviewed 40 eyes of 40 patients with open globe eye injury who were presented to Juntendo University Shizuoka Hospital and required emergency surgery during the 4 years from January 2010 to December 2014. Retrospective evaluation of the visual outcome was performed using data from the medical records, including assessment of the influence of sex, side of the eye injury, cause of injury, and site/severity of injury. Results The mean age (SD) at the time of the injury was 58.9 years (±25.1 years). There were 28 males (70.0%) and 12 females (30.0%). Statistically significant improvement in visual acuity after treatment was noted in the males (P=0.0015, Wilcoxon test), but not in the females. Twenty-five patients had injury to the right eye (62.5%) and 15 had injury to the left eye (37.5%). A significant improvement in visual acuity was achieved after treatment of injury to the right eye (P=0.021), but not the left eye (P=0.109). The most frequent cause of injury was an accident (15 eyes; 37.5%). The second most frequent cause was work-related injury (14 eyes; 35.0%), which only occurred in males, and the third cause was accident due to negligence (eleven eyes; 27.5%). Two patients developed sympathetic ophthalmia and one patient developed postoperative endophthalmitis. Conclusion The majority of patients with open globe eye injury were male workers in Japan. The visual outcome of work-related injury was better than that of injury due to other causes. The visual outcome was also better if the right eye was injured compared with the left eye. Patients with injuries due to negligence were older than the other groups, and this finding might be characteristic of an aging society. PMID

  12. LSD alters eyes-closed functional connectivity within the early visual cortex in a retinotopic fashion.

    Science.gov (United States)

    Roseman, Leor; Sereno, Martin I; Leech, Robert; Kaelen, Mendel; Orban, Csaba; McGonigle, John; Feilding, Amanda; Nutt, David J; Carhart-Harris, Robin L

    2016-08-01

    The question of how spatially organized activity in the visual cortex behaves during eyes-closed, lysergic acid diethylamide (LSD)-induced "psychedelic imagery" (e.g., visions of geometric patterns and more complex phenomena) has never been empirically addressed, although it has been proposed that under psychedelics, with eyes-closed, the brain may function "as if" there is visual input when there is none. In this work, resting-state functional connectivity (RSFC) data was analyzed from 10 healthy subjects under the influence of LSD and, separately, placebo. It was suspected that eyes-closed psychedelic imagery might involve transient local retinotopic activation, of the sort typically associated with visual stimulation. To test this, it was hypothesized that, under LSD, patches of the visual cortex with congruent retinotopic representations would show greater RSFC than incongruent patches. Using a retinotopic localizer performed during a nondrug baseline condition, nonadjacent patches of V1 and V3 that represent the vertical or the horizontal meridians of the visual field were identified. Subsequently, RSFC between V1 and V3 was measured with respect to these a priori identified patches. Consistent with our prior hypothesis, the difference between RSFC of patches with congruent retinotopic specificity (horizontal-horizontal and vertical-vertical) and those with incongruent specificity (horizontal-vertical and vertical-horizontal) increased significantly under LSD relative to placebo, suggesting that activity within the visual cortex becomes more dependent on its intrinsic retinotopic organization in the drug condition. This result may indicate that under LSD, with eyes-closed, the early visual system behaves as if it were seeing spatially localized visual inputs. Hum Brain Mapp 37:3031-3040, 2016. © 2016 Wiley Periodicals, Inc.

  13. LS1 Report: As one door closes, another opens

    CERN Multimedia

    Katarina Anthony & Anaïs Schaeffer

    2014-01-01

    Across the PS complex - from Linac 2 to TT2 to the accelerator itself - teams have seen the closing of their retro-1980s entryways, and the opening of state-of-the-art access points in compliance with the highest nuclear safety standards.   One of the new PS access points. The new PS access system provides more than just doors. Designed to protect against the radiation hazards and other risks caused by machine operation, the access system will monitor who goes into each zone, check whether or not the individual has the appropriate permissions to be entering, and even stop the beam if access is attempted during beam mode. "These new points provide automatic means to check that the right people are going in and in safe circumstances," says Pierre Ninin, project leader of the PS complex safety system. "All of these checks were previously done manually, so the burden on operators has been significantly reduced." The 19 new access points were successfully insta...

  14. Detecting Aortic Valve Opening and Closing from Distal Body Vibrations

    CERN Document Server

    Wiens, Andrew D; Inan, Omer T

    2016-01-01

    Objective: Proximal and whole-body vibrations are well studied in seismocardiography and ballistocardiography, yet distal vibrations are still poorly understood. In this paper we develop two methods to measure aortic valve opening (AVO) and closing (AVC) from distal vibrations. Methods: AVO and AVC were detected for each heartbeat with accelerometers on the upper arm (A), wrist (W), and knee (K) of 22 consenting adults following isometric exercise. Exercise-induced changes were recorded with impedance cardiography, and nine-beat ensemble averaging was applied. Our first method, FilterBCG, detects peaks in distal vibrations after filtering with individually-tuned bandpass filters while RidgeBCG uses ridge regression to estimate AVO and AVC without peaks. Pseudocode is provided. Results: In agreement with recent studies, we did not find peaks at AVO and AVC in distal vibrations, and the conventional R-J interval method from the literature also correlated poorly with AVO (r2 = 0.22 A, 0.14 W, 0.12 K). Interestin...

  15. Entropy production for closed, open and third-kind systems

    Energy Technology Data Exchange (ETDEWEB)

    Sertorio, L.; Tinetti, G. [Turin Univ. (Italy). Dipt. di Fisica Teorica

    1999-07-01

    The authors refer to nonequilibrium thermodynamics where the concept of entropy production in defined. Remember that the formalism of equilibrium thermodynamics describes reversible transformations; in this formalism entropy is a state function, for a infinitesimal transformation they have dS=dQ{sub r}ev/T, entropy grows if heat is received, diminishes if heat is released and remains unchanged if the transformation is adiabatic, dQ=O. The formulation of nonequilibrium thermodynamic is not unique, they are two version, one discrete and one continuous: 1) Onsager formulation (1): ordinary differential equations. 2) Landau formulation (2): irreversible field theory. The two formulations do not differ in physical content, in fact the discrete formalism can be considered as a reduction of the continuous formalism and conversely the discrete formalism can be generalised to the continuous one, The continuous, or field theoretical approach, has the advantage that it leads to a spontaneous extension to the relativistic formalism (2). Regardless of the choice 1. or 2., in nonequilibrium thermodynamics any irreversibility is taken into account explicitly, the irreversible event begin: heat diffusion, viscosity and chemical reactions. The distinction among close and open systems applies to equilibrium and nonequilibrium thermodynamics as well.

  16. The effect of an eyes-closed dance-specific training program on dynamic balance in elite pre-professional ballet dancers: a randomized controlled pilot study.

    Science.gov (United States)

    Hutt, Kimberley; Redding, Emma

    2014-03-01

    Visual conditions for a dancer vary greatly between theatrical performance environments and dance studios, and this variability may be detrimental to their dynamic balance performance, particularly under stage lighting. In order to maintain balance control, dancers reportedly rely heavily on visual input, yet those who rely more on proprioceptive strategies for balancing have been found to be more stable. The purpose of this study was to assess the capability of an eyes-closed, dance-specific training program to nurture in dancers proprioceptive mechanisms that may facilitate their dynamic balance control. Eighteen elite pre-professional ballet dancers were randomly assigned to either a control (eyes open) or experimental (eyes closed) group for the intervention. The balance abilities of all subjects were tested using five dance-specific variations of the Star Excursion Balance Test before and after a 4 week balance intervention. Reach distance and time to complete the tests were recorded separately as indirect measurements of dynamic balance. The intervention consisted of dance-specific, eyes-closed exercises integrated into the dancers' daily ballet class and designed progressively to challenge the dancers' balance. During the intervention period, the control group undertook the same exercise program with their eyes open. Results revealed significant improvements in time to complete the three "timed" balance tests, and distances reached significantly improved in one of the two "reach" balance tests. No significant improvements were observed in the control group for any variation of the tests. These results indicate that dancers can be trained to adopt proprioceptive strategies to maintain dynamic balance, which consequently improves their balance performance. Such findings could encourage use of eyes-closed training in daily dance classes due to its potential to improve dancers' balance control.

  17. Deformations of closed strings and topological open membranes

    NARCIS (Netherlands)

    Hofman, C.; Ma, W.K.

    2001-01-01

    We study deformations of topological closed strings. A well-known example is the perturba- tion of a topological closed string by itself, where the associative OPE product is deformed, and which isgoverned by the WD VV equations. Our main in terest will be closed strings that arise as the

  18. Open and Closed String field theory interpreted in classical Algebraic Topology

    OpenAIRE

    Sullivan, Dennis

    2003-01-01

    There is an interpretation of open string field theory in algebraic topology. An interpretation of closed string field theory can be deduced from this open string theory to obtain as well the interpretation of open and closed string field theory combined.

  19. Open and Closed String field theory interpreted in classical Algebraic Topology

    OpenAIRE

    Sullivan, Dennis

    2003-01-01

    There is an interpretation of open string field theory in algebraic topology. An interpretation of closed string field theory can be deduced from this open string theory to obtain as well the interpretation of open and closed string field theory combined.

  20. Off-line integration of CE and MALDI-MS using a closed-open-closed microchannel system.

    Science.gov (United States)

    Jacksén, Johan; Frisk, Thomas; Redeby, Theres; Parmar, Varun; van der Wijngaart, Wouter; Stemme, Göran; Emmer, Asa

    2007-07-01

    In this work, a new technique for off-line hyphenation between CE and MALDI-MS is presented. Two closed fused-silica capillaries were connected via a silicon chip comprising an open microcanal. The EOF in the system was evaluated using mesityloxide or leucine-enkephalin as a sample and with a running buffer that rendered the analyte neutrally charged. Comparison was made between the EOF in a closed system (first capillary solely included in the electrical circuit) and in a closed-open system (first capillary and microcanal included in the electrical circuit). It was concluded that the experimental values of the EOF agreed with the theory. The influence of the capillary outer diameter on the peak dispersion was investigated using a closed-open-closed system (first capillary, microcanal and second capillary included in the electrical circuit). It was clearly seen that a capillary with 375 microm od induced considerably higher peak dispersion than a 150 microm od capillary, due to a larger liquid dead volume in the connection between the first capillary outlet and the microcanal. Mass spectrometric analysis has also been performed following CE separation runs in a closed-open-closed system with cytochrome c and lysozyme as model proteins. It was demonstrated that a signal distribution profile of the separated analytes could be recorded over a 30 mm long microcanal.

  1. Stepping in Place While Voluntarily Turning Around Produces a Long-Lasting Posteffect Consisting in Inadvertent Turning While Stepping Eyes Closed

    Directory of Open Access Journals (Sweden)

    Stefania Sozzi

    2016-01-01

    Full Text Available Training subjects to step in place on a rotating platform while maintaining a fixed body orientation in space produces a posteffect consisting in inadvertent turning around while stepping in place eyes closed (podokinetic after-rotation, PKAR. We tested the hypothesis that voluntary turning around while stepping in place also produces a posteffect similar to PKAR. Sixteen subjects performed 12 min of voluntary turning while stepping around their vertical axis eyes closed and 12 min of stepping in place eyes open on the center of a platform rotating at 60°/s (pretests. Then, subjects continued stepping in place eyes closed for at least 10 min (posteffect. We recorded the positions of markers fixed to head, shoulder, and feet. The posteffect of voluntary turning shared all features of PKAR. Time decay of angular velocity, stepping cadence, head acceleration, and ratio of angular velocity after to angular velocity before were similar between both protocols. Both postrotations took place inadvertently. The posteffects are possibly dependent on the repeated voluntary contraction of leg and foot intrarotating pelvic muscles that rotate the trunk over the stance foot, a synergy common to both protocols. We propose that stepping in place and voluntary turning can be a scheme ancillary to the rotating platform for training body segment coordination in patients with impairment of turning synergies of various origin.

  2. Spectral power and functional connectivity changes during mindfulness meditation with eyes open: A magnetoencephalography (MEG) study in long-term meditators.

    Science.gov (United States)

    Wong, W P; Camfield, D A; Woods, W; Sarris, J; Pipingas, A

    2015-10-01

    Whilst a number of previous studies have been conducted in order to investigate functional brain changes associated with eyes-closed meditation techniques, there is a relative scarcity in the literature with regards to changes occurring during eyes-open meditation. The current project used magnetoencephalography (MEG) to investigate differences in spectral power and functional connectivity between 11 long-term mindfulness meditators (LTMMs) with >5 years of experience and 12 meditation-naïve control participants both during baseline eyes-open rest and eyes-open open-monitoring (OM) mindfulness meditation. During resting with eyes-open, prior to meditating, greater mean alpha power was observed for LTMMs in comparison to controls. However, during the course of OM meditation, a significantly greater increase in theta power was observed over a broad fronto-centro-parietal region for control participants in comparison to LTMMs. In contrast, whole-head mean connectivity was found to be significantly greater for long-term meditators in comparison to controls in the theta band both during rest as well as during meditation. Additionally, mean connectivity was significantly lower for long-term meditators in the low gamma band during rest and significantly lower in both low and high gamma bands during meditation; and the variance of low-gamma connectivity scores for long-term meditators was significantly decreased compared to the control group. The current study provides important new information as to the trait functional changes in brain activity associated with long-term mindfulness meditation, as well as the state changes specifically associated with eyes-open open monitoring meditation techniques.

  3. Fuzzy Sets, Fuzzy S-Open and S-Closed Mappings

    OpenAIRE

    Ahmad, B; Athar Kharal

    2009-01-01

    Several properties of fuzzy semiclosure and fuzzy semi-interior of fuzzy sets defined by Yalvac (1988), have been established and supported by counterexamples. We also study the characterizations and properties of fuzzy semi-open and fuzzy semi-closed sets. Moreover, we define fuzzy s-open and fuzzy s-closed mappings and give some interesting characterizations.

  4. Study Behavior in the Closed-Book and the Open-Book Examination: A Comparative Analysis.

    Science.gov (United States)

    Theophilides, Christos; Koutselini, Mary

    2000-01-01

    Investigated the study behavior used by students facing an open-book or closed-book examination. Results for 201 college students in Cyprus indicate that students preparing for a closed-book examination tended to postpone study at the end of the semester, focus on assigned texts, and memorize information. Students preparing for open-book tests…

  5. A mathematical model on the closing and opening mechanism for venus flytrap.

    Science.gov (United States)

    Yang, Ruoting; Lenaghan, Scott C; Zhang, Mingjun; Xia, Lijin

    2010-08-01

    This paper investigates the opening and closing mechanism for the Venus Flytrap (Dionaea muscipula). A mathematical model has been proposed to explain how the flytrap transitions between open, semi-closed, and closed states. The model accounts for the charge accumulation of action potentials, which generated by mechanical stimulation of the sensitive trigger hairs on the lobes of the flytrap. Though many studies have been reported for the Venus flytrap opening and closing mechanism, this paper attempts to explain the mechanism from nonlinear dynamics and control perspective.

  6. Analytical Study for Stress Wave Interaction with Rock Joints Having Unequally Close-Open Behavior

    Science.gov (United States)

    Li, J. C.; Zhao, X. B.; Li, H. B.; Chai, S. B.; Zhao, Q. H.

    2016-08-01

    Stress wave interaction with rock joints during wave propagation is usually dependent on the dynamic response of the joints. During wave propagation, joints may be closed and open under the effects of the stress wave and the in situ stress. A joint in nature can only resist load during close process. In this paper, the close and open behaviors of rock joints are considered to be different. The joints are assumed to be linearly elastic in close status but turn into free surfaces in open status. Wave propagation equation across joints with unequally close-open behavior is first derived and expressed as a time-differential form based on the displacement discontinuity method. SHPB test recording is then adopted to verify the present approach, which is also compared with the results from existing methods for joints with equally close-open behavior. Next, analysis is conduced for wave propagation across a single joint and a set of parallel joints with unequally close-open behavior, respectively. From the analysis, effects of unequally close-open behavior of a joint on wave propagation and the dynamic response of the joint are studied finally.

  7. Regularity of Center of Pressure Trajectories in Expert Gymnasts during Bipedal Closed-Eyes Quiet Standing

    Directory of Open Access Journals (Sweden)

    Brice Isableu

    2017-06-01

    Full Text Available We compared postural control of expert gymnasts (G to that of non-gymnasts (NG during bipedal closed-eyes quiet standing using conventional and nonlinear dynamical measures of center of foot pressure (COP trajectories. Earlier findings based on COP classical variables showed that gymnasts exhibited a better control of postural balance but only in demanding stances. We examined whether the effect of expertise in Gymnastic can be uncovered in less demanding stances, from the analysis of the dynamic patterns of COP trajectories. Three dependent variables were computed to describe the subject’s postural behavior: the variability of COP displacements (ACoP, the variability of the COP velocities (VCoP and the sample entropy of COP (SEnCoP to quantify COP regularity (i.e., predictability. Conventional analysis of COP trajectories showed that NG and G exhibited similar amount and control of postural sway, as indicated by similar ACoP and VCoP values observed in NG and G, respectively. These results suggest that the specialized balance training received by G may not transfer to less challenging balance conditions such as the bipedal eyes-closed stance condition used in the present experiment. Interestingly, nonlinear dynamical analysis of COP trajectories regarding COP regularity showed that G exhibited more irregular COP fluctuations relative to NG, as indicated by the higher SEnCoP values observed for the G than for the NG. The present results showed that a finer-grained analysis of the dynamic patterns of the COP displacements is required to uncover an effect of gymnastic expertise on postural control in nondemanding postural stance. The present findings shed light on the surplus value in the nonlinear dynamical analysis of COP trajectories to gain further insight into the mechanisms involved in the control of bipedal posture.

  8. Contrasting effects of managed opening regimes on water quality in two intermittently closed and open coastal lakes

    Science.gov (United States)

    Schallenberg, M.; Larned, S. T.; Hayward, S.; Arbuckle, C.

    2010-03-01

    Intermittently closed and open lakes and lagoons (ICOLLs) are shallow barrier lakes which are intermittently connected to the sea and experience saline intrusions. Many ICOLLs are mechanically opened to prevent flooding of surrounding agricultural and urban land and to flush water of poor quality. In this study, the effects of modified opening regimes (frequency and duration of barrier openings and closures) on water quality and phytoplankton in two New Zealand ICOLLs were investigated over a number of opening/closure cycles. Water quality in Lake Ellesmere (Te Waihora) responded weakly to both opening and closing events, indicating that sea-ICOLL exchange did not markedly improve water quality. Conversely, water quality in Waituna Lagoon responded rapidly to barrier openings; water level decreased to near sea level within days of opening and subsequent seawater exchange resulted in rapid decreases in nitrate and chlorophyll a concentrations. The closure of Waituna Lagoon resulted in rapid rise in water level and a pulse of nitrate and phosphorus in the water column and phytoplankton chlorophyll a concentrations increased with increasing closed-period duration. Based on data on the underwater light climate and nutrient dynamics, phytoplankton in Lake Ellesmere was probably light-limited, whereas phytoplankton in Waituna Lagoon was rarely light-limited, and appeared to be predominately P-limited. The marked differences in responses of Lake Ellesmere and Waituna Lagoon to barrier openings and closures reflected differences in ICOLL water levels and morphological characteristics, which dictated the degree of tidal flushing when the barriers were open. The inter-ICOLL differences observed in this study indicate that unless the effects of ICOLL openings/closures on phytoplankton and nutrient dynamics are understood, changes to ICOLL opening regimes may have unintended consequences for the water quality and ecology of these systems.

  9. Numerical Analysis of Combined Well and Open-Closed Loops Geothermal (CWG) Systems

    Science.gov (United States)

    Park, Yu-Chul

    2016-04-01

    Open-loop geothermal heat pump (GHP) system and closed-loop heat pump systems have been used in Korea to reduce emission of greenhouse gases such as carbon dioxide (CO2). The GHP systems have the pros and cons, for example, the open-loop GHP system is good energy-efficient and the closed-loop GHP system requires minimum maintenance costs. The open-loop GHP system can be used practically only with large amount of groundwater supply. The closed-loop GHP system can be used with high costs of initial installation. The performance and efficiency of the GHP system depend on the characteristics of the GHP system itself in addition to the geologic conditions. To overcome the cons of open-loop or closed-loop GHP system, the combined well and open-closed loops geothermal (CWG) system was designed. The open-loop GHP system is surrounded with closed-loop GHP systems in the CWG system. The geothermal energy in closed-loop GHP systems is supplied by the groundwater pumped by the open-loop GHP system. In this study, 2 different types of the CWG systems (small aperture hybrid CWG system and large aperture CWG system) are estimated using numerical simulation models in the aspect of energy efficiency. This work was supported by the New & Renewable Energy Core Technology Program of the Korea Institute of Energy Technology Evaluation and Planning (KETEP), granted financial resource from the Ministry of Trade, Industry & Energy, Republic of Korea. (No.20153030111120).

  10. Investigation of Eccentric Open Eye Formation in a Slab Caster Tundish

    Science.gov (United States)

    Chatterjee, Saikat; Li, Donghui; Leung, Jackie; Sengupta, Joydeep; Chattopadhyay, Kinnor

    2017-04-01

    Inert gas shrouding in tundish can result in the formation of a tundish open eye (TOE) due to the presence of reversed flows on the upper surface of the tundish. Prolonged presence of open eyes promotes reoxidation of liquid steel and creates harmful inclusions, which can ultimately result in clogging of SENs. In spite of its importance, not much work has been performed on TOEs. In our series of recent works (Chattopadhyay in Modelling of Transport Phenomena for Improved Steel Quality in a Delta-Shaped Four Strand Tundish, 2011; Chattopadhyay et al. in ISIJ Int 51: 573-580, 2011; Chatterjee and Chattopadhyay in ISIJ Int 55: 1416-1424, 2015; Metall Mater Trans B 41: 508-521, 2016; Metall Mater Trans B 47: 3099-3114, 2016; Chatterjee et al. in ISIJ Int 56: 1889-1892, 2016), although substantial efforts have been made to understand the basics of TOE formation process, a lot still remains to be deciphered. The current work deals with investigating a strange phenomenon observed during tundish operations: eccentric open eye formation. It is essential to gain proper insights of this matter in order to improve the operations, enhance liquid metal cleanliness, and generate more revenues. A mathematical model was developed using ANSYS-FLUENT 16.2. The standard k- ɛ turbulence model and the discrete phase method, coupled with the discrete random walk model was employed. Three different causes for eccentric open eye formation viz., unbalanced throughput, biased argon injection, and misalignment of ladle shroud have been analyzed. The predicted results correspond to both water model experiments and real plant observations.

  11. Closing one's eyes to reality: evidence for a dopaminergic basis of psychoticism from spontaneous eye blink rates

    NARCIS (Netherlands)

    L.S. Colzato; H.A. Slagter; W.P.M. van den Wildenberg; B. Hommel

    2009-01-01

    We tested the idea that Psychoticism, a major personality dimension, is rooted in individual differences in dopamine functioning. To this end, we related the spontaneous eye blink rate (EBR), a marker of striatal dopaminergic activity, to scores in the Eysenck Personality Questionnaire Revised Short

  12. Free torsion of thin-walled structural members of open- and closed-sections

    Institute of Scientific and Technical Information of China (English)

    Long-yuan LI; D. EASTERBROOK

    2014-01-01

    Free torsion of thin-walled structures of open- and closed-sections is a classical elastic mechanics problem, which, in literature, is often solved by the method of membrane analogy. The method of membrane analogy, however, can be only applied to structures of a single material. If the structure consists of both open-and closed-sections, the method of membrane analogy is difficult to be applied. In this paper, a new method is presented for solving the free torsion of thin-walled structures of open- and/or closed-sections with multiple materials. By utilizing a simple statically indeterminate concept, torsional equations are derived based on the equilibrium and compatibility conditions. The method presented here not only is very simple and easy to understand but also can be applied to thin-walled structures of combined open-and closed-sections with multiple materials.

  13. Imagery use of athletes in individual and team sports that require open and closed skill.

    Science.gov (United States)

    Kizildag, Esen; Tiryaki, M Sefik

    2012-06-01

    This study compared use of imagery in elite male and female athletes in open and closed and individual or team sports. A total of 151 elite Turkish athletes ages 15 to 29 years old (males' M age=20.7 yr., SD=3.3; females' M age=20.0 yr., SD=3.5) from open-team sports (n=66), open-individual sports (n=26), and closed-individual sports (n=59) completed the sport imagery questionnaire. A significant multivariate effect of sport type was found. Univariate analyses indicated that male and female athletes in team open-skill sports and individual closed-skill sports used more motivational general-mastery imagery than did athletes in individual open-skill sports.

  14. Opening and closing formulae in Tswana folktales: A structural and functional analysis

    Directory of Open Access Journals (Sweden)

    S. A. Swanepoel

    1983-05-01

    Full Text Available Opening and closing formulae are acknowledged by many research workers and specialists of folktales. It is therefore a pity that although most researchers have recognized it, here is a tendency to neglect the layout of the structure and the functions played by the formulae. In this discussion attention will be paid to the structure and the various functions of the formulae, because the opening and closing formulae, as a unity, constitute one of the main structural features of folktales.

  15. Comparison of body-powered voluntary opening and voluntary closing prehensor for activities of daily life

    OpenAIRE

    Kelsey Berning; Sarah Cohick; Reva Johnson, MS; Laura Ann Miller, PhD, CP; Jonathon W. Sensinger, PhD

    2014-01-01

    Persons with an upper-limb amputation who use a body-powered prosthesis typically control the prehensor through contralateral shoulder movement, which is transmitted through a Bowden cable. Increased cable tension either opens or closes the prehensor; when tension is released, some passive element, such as a spring, returns the prehensor to the default state (closed or open). In this study, we used the Southampton Hand Assessment Procedure to examine functional differences between these two t...

  16. Modeling Aerosol-Cloud Interactions in Marine Open- and Closed-Cell Stratocumulus

    Science.gov (United States)

    Wang, H.; Feingold, G.

    2008-12-01

    Satellite imagery shows the recurrence of striking images of cellular structures exhibiting both closed- and open-cell patterns in marine stratocumulus fields. The open-cell region has much lower cloud albedo than closed cells. Aside from that, previous observational and modeling studies have suggested that open- and closed-cell regions are different in many other aspects, such as concentration of cloud condensation nuclei (CCN), cloud droplet number and size, precipitation efficiency, and cloud dynamics. In this work, aerosol- cloud interactions and dynamical feedbacks are investigated within a large eddy simulation (LES) modeling framework to study the activation, cloud scavenging, mixing and transport of CCN in the open- and closed- cell boundary layer and near the open/closed-cell boundaries. The model domain size of 120 km by 60 km is large enough to represent mesoscale organizations that are associated with different cellular structures and that are promoted by CCN perturbation from ship emissions. Simulation results show that depletion of CCN by collision and coalescence in clouds is critical to the formation of precipitation and open-cell structure in a stratocumulus deck. Once the open cellular structure has formed in the clean environment, a substantial increase of CCN transported from a neighboring polluted environment or from ship emissions do not close it during the 12-hour simulation due to the lack of dynamical and moisture support in the open-cell cloud-free region. However, the contaminated open cells are not able to self-sustain as a result of shutoff of precipitation. This points to the critical role of precipitation-triggered circulations in maintaining an open-cellular structure.

  17. Phytoplankton composition and microcystin concentrations in open and closed bays of Lake Victoria, Tanzania

    Science.gov (United States)

    Mbonde, Athanasio S.; Sitoki, Lewis; Kurmayer, Rainer

    2017-01-01

    This study was carried out in order to investigate the spatial variation of algal toxin (microcystin) concentrations along the shoreline of Lake Victoria. A total of 16 nearshore stations differing in connectivity to the main lake basin were categorized as either closed bays (ratio of bay area to bay opening < 1) or open bays (ratio ≥ 1) and sampled during November and December 2009. Water samples were analyzed for total phosphorus (TP), chlorophyll a, phytoplankton community composition and concentrations of microcystin (MC). Open and closed bays were significantly different for phytoplankton abundance and composition: Average phytoplankton biovolume was higher for closed bays (45 mm3 L-1 ± 11 SE) than open bays (5 ± 2 mm3 L-1). Cyanobacterial biovolume (mainly Microcystis spp., Anabaena spp. and Planktolyngbya spp.) also was significantly higher in closed bays (82 ± 9% of total biovolume) than in open bays (44 ± 5%). In contrast, diatom biovolume was lower in closed bays (7 ± 1%) than in open bays (36 ± 6%). MCs were found only among sites from closed bays and concentrations ranged from 0.4 to 13 μg L-1 MC-LR equiv. and coincided with high abundance of Microcystis spp. It is concluded that the level of water exchange from individual bays to the main basin is an important factor influencing eutrophication and microcystin production in nearshore habitats of Lake Victoria. PMID:28077928

  18. {open_quotes}BIOX{close_quotes} hydrogen sulfide abatement process - application analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gallup, D.L. [UNOCAL Corp., Santa Rosa, CA (United States)

    1996-12-31

    A new hydrogen sulfide abatement process, known as {open_quotes}BIOX,{close_quotes} has been specifically developed for the geothermal industry. {open_quotes}BIOX{close_quotes} (biocide induced oxidation) successfully controls both primary and secondary emissions from cooling towers in pilot, demonstration, and commercial operations by air-wet oxidation. Independent laboratory tests recently controverted the efficacy of {open_quotes}BIOX{close_quotes} to catalytically oxidize sulfides to sulfate. Studies conducted in our laboratory with a simulated cooling tower indicate that the experimental conditions employed by Nardini, et al, are unrealistic for geothermal cooling towers. Furthermore, our investigations demonstrate that the {open_quotes}BIOX{close_quotes} process performs optimally at near neutral pH, a condition common to most geothermal cooling tower circulating water systems. A {open_quotes}BIOX{close_quotes} agent, trichloroisocyanuric acid (TCCA), proved to mitigate sulfide emissions much more efficiently than air, sodium hypochlorite or chlorine dioxide. {open_quotes}BIOX{close_quotes} is a proven, cost-effective H{sub 2}S abatement technology.

  19. A novel mechanism controls anther opening and closing in Paris polyphylla var. Yunnanensis

    Institute of Scientific and Technical Information of China (English)

    WANG DingKang; SUN GuiFang; WANG LiFang; ZHAI ShuHua; CEN XiaoJiang

    2009-01-01

    a School of Information Science and Engineering, Yunnan University, Kunming 650091, China The phenomena of anther opening and closing in Paris polyphylla var. yunnanensis (Franch)Hand.-Mazz were described in detail, and the effects of ecological factors on those phenomena related to anther opening, closing and the fly-pollination mechanism were discussed. Anthers of P. polyphylla var. yunnanensls open in the morning and close in the evening every day during an over 20 days' pe-riod of anthesis. Light was detected as the main factor controlling this daily anther opening and closing.Anther opening can be reversed in response to rain and re-opens when rain stops. Relative humidity (RH) has a slight effect on anther opening and closing. Flower spans can be prolonged under labora-tory conditions. This novel behavior of anther is likely to be a mechanism to enhance the male fitness in this species, of which has no inherited structure to protect pollen from the perianth.

  20. Why Do Young Children Hide by Closing Their Eyes? Self-Visibility and the Developing Concept of Self

    Science.gov (United States)

    Russell, James; Gee, Brioney; Bullard, Christina

    2012-01-01

    In a series of four experiments, the authors begin by replicating Flavell, Shipstead, and Croft's (1980) finding that many children between 2 and 4 years of age will affirm the invisibility both of themselves and of others--but "not" of the body--when the person's eyes are closed. The authors also render explicit certain trends in the Flavell et…

  1. Approach to management of eyes with no light perception after open globe injury

    Directory of Open Access Journals (Sweden)

    Neelakshi Bhagat

    2016-01-01

    Full Text Available Loss of light perception (LP after open globe injury (OGI does not necessarily mean the patient will have permanent complete visual loss. Findings that seem to be associated reliably with permanent profound vision loss after OGI include optic nerve avulsion, optic nerve transection, and profound loss of intraocular contents, which can be identified with CT/MRI imaging albeit with varying degrees of confidence. Eyes with NLP after OGI that undergo successful primary repair with intact optic nerves may be considered for additional surgery, particularly if there is: (1 recovery of LP on the first day after primary repair; (2 treatable pathology underlying NLP status (e.g., extensive choroidal hemorrhage, dense vitreous and subretinal hemorrhage; (3 NLP in the fellow eye. We counsel patients that the chance of recovering ambulatory vision under these circumstances is very low (~5%.

  2. Closed String S-matrix Elements in Open String Field Theory

    CERN Document Server

    Garousi, M R; Garousi, Mohammad R

    2005-01-01

    Using the gauge invariant operators corresponding to on-shell closed string states in open string field theory, we study the tree level S-matrix element of two arbitrary closed string states, and the S-matrix element of one closed string and two open string states. By mapping the world-sheet of the amplitudes to the upper half z-plane, and by evaluating the correlators in the ghost parts, we show that the S-matrix elements are exactly identical to the corresponding disk level S-matrix elements in bosonic string theory.

  3. Closed String S-matrix Elements in Open String Field Theory

    Science.gov (United States)

    Garousi, Mohammad R.; Maktabdaran, G. R.

    2005-03-01

    We study the S-matrix elements of the gauge invariant operators corresponding to on-shell closed strings, in open string field theory. In particular, we calculate the tree level S-matrix element of two arbitrary closed strings, and the S-matrix element of one closed string and two open strings. By mapping the world-sheet of these amplitudes to the upper half z-plane, and by evaluating explicitly the correlators in the ghost part, we show that these S-matrix elements are exactly identical to the corresponding disk level S-matrix elements in perturbative string theory.

  4. Comparative Kinetic Analysis of Closed-Ended and Open-Ended Porous Sensors

    Science.gov (United States)

    Zhao, Yiliang; Gaur, Girija; Mernaugh, Raymond L.; Laibinis, Paul E.; Weiss, Sharon M.

    2016-09-01

    Efficient mass transport through porous networks is essential for achieving rapid response times in sensing applications utilizing porous materials. In this work, we show that open-ended porous membranes can overcome diffusion challenges experienced by closed-ended porous materials in a microfluidic environment. A theoretical model including both transport and reaction kinetics is employed to study the influence of flow velocity, bulk analyte concentration, analyte diffusivity, and adsorption rate on the performance of open-ended and closed-ended porous sensors integrated with flow cells. The analysis shows that open-ended pores enable analyte flow through the pores and greatly reduce the response time and analyte consumption for detecting large molecules with slow diffusivities compared with closed-ended pores for which analytes largely flow over the pores. Experimental confirmation of the results was carried out with open- and closed-ended porous silicon (PSi) microcavities fabricated in flow-through and flow-over sensor configurations, respectively. The adsorption behavior of small analytes onto the inner surfaces of closed-ended and open-ended PSi membrane microcavities was similar. However, for large analytes, PSi membranes in a flow-through scheme showed significant improvement in response times due to more efficient convective transport of analytes. The experimental results and theoretical analysis provide quantitative estimates of the benefits offered by open-ended porous membranes for different analyte systems.

  5. Predictive Value Of Ocular Trauma Score In Open Globe Combat Eye Injuries.

    Science.gov (United States)

    Islam, Qamar Ul; Ishaq, Mazhar; Yaqub, Muhammad Amer; Mehboob, Mohammad Asim

    2016-01-01

    Prediction of final visual outcome in ocular injuries is of paramount importance and various prognostic models have been proposed to predict final visual outcome. The objective of this study was to validate the predictive value of ocular trauma score (OTS) in patients with combat related open globe injuries and to evaluate the factors affecting the final visual outcome. Data of 93 patients admitted in AFIO Rawalpindi between Jan 2010 to June 2014 with combat related open globe ocular injuries was analysed. Initial and final best corrected visual acuity (BCVA) was categorized as No Light Perception (NLP), Light Perception (LP) to Hand Movement (HM), 1/200-19/200, 20/200-20/50, and ≥20/40. OTS was calculated for each eye by assigning numerical raw points to six variables and then scores were stratified into five OTS categories. Mean age of study population was 28.77±8.37 years. Presenting visual acuity was <20/200 (6/60) in 103 (96.23%) eyes. However, final BCVA of ≥20/40 (6/12) was achieved in 18 (16.82%) eyes, while 72 (67.28%) eyes had final BCVA of <20/200 (6/60). Final visual outcome in our study were similar to those in OTS study, except for NLP in category 1 (81% vs. 74%) and ≥20/40 in category 3 (30% vs. 41%). The OTS model predicted visual survival (LP or better) with a sensitivity of 94.80% and predicted no vision (NLP) with a specificity of 100%. OTS is a reliable tool for assessment of ocular injuries and predicting final visual outcome at the outset.

  6. Open and Closed String Vertices for branes with magnetic field and T-duality

    CERN Document Server

    Pesando, I

    2009-01-01

    We discuss carefully the vertices which describe the dipole open strings and closed strings on a D-brane with magnetic flux on a torus. Translation invariance along closed cycles forces surprisingly closed string vertices written in open string formalism to acquire Chan-Paton like matrices. Moreover the one loop amplitudes have a single trace for the part of gauge group with the magnetic flux. These peculiarities are also required by consistency of the action of T-duality in the open string sector. In this way we can show to all orders in perturbation theory the equivalence of the T-dual open string theories, gravitational interactions included. We provide also a new and direct derivation of the bosonic boundary state in presence of constant magnetic and Kalb-Ramond background based on Sciuto-Della Selva-Saito vertex formalism.

  7. Open and closed string vertices for branes with magnetic field and T-duality

    Science.gov (United States)

    Pesando, Igor

    2010-02-01

    We discuss carefully the vertices which describe the dipole open strings and closed strings on a D-brane with magnetic flux on a torus. Translation invariance along closed cycles forces surprisingly closed string vertices written in open string formalism to acquire Chan-Paton like matrices. Moreover the one loop amplitudes have a single trace for the part of gauge group with the magnetic flux. These peculiarities are also required by consistency of the action of T-duality in the open string sector. In this way we can show to all orders in perturbation theory the equivalence of the T-dual open string theories, gravitational interactions included. We provide also a new and direct derivation of the bosonic boundary state in presence of constant magnetic and Kalb-Ramond background based on Sciuto-Della Selva-Saito vertex formalism.

  8. Influence of spontaneous nystagmus with eyes closed on computerized vestibular exam of patients with chronic peripheral

    Directory of Open Access Journals (Sweden)

    Shin, Elizabeth

    2010-06-01

    Full Text Available Introduction: The spontaneous nystagmus with eyes closed (NEOF can modify the results obtained during some evidence of vestibular, leading to erroneous conclusions. Objective: To characterize the patients and the type of influence on the evidence of NEOF vectonystagmography digital. Method: Retrospective study based on survey charts of patients with the presence of NEOF vectonystagmography digital, in the Outpatient Equilibriometria UNIFESP-EPM, in the years 2000 to 2007. Comparisons were made between genders, ages, direction, angular velocity of NEOF, completion of entrance examination and its influence on the results of caloric testing. Results: We found 73.7% of the population was female, mean age of 55.08 years; NEOF prevalence of horizontal and angular velocity smaller than 7o/s in 86.7%. 59% had some kind of influence caused by the caloric test NEOF as inversion, hyporeflexia, hyperreflexia, nystagmus directional preponderance (NDP and labyrinthine preponderance (LP changed. The most prevalent findings were normal vestibular tests (EVN and bilateral irritative peripheral vestibular syndrome (BIPVS. 38.7% caloric ice and realized these cases it was possible to reach a conclusion in 79%. Conclusion: The NEOF most common was the horizontal type, with VACL less than 7o/s, influencing the majority of examinations and only the results of caloric testing the air, with reversal of post-caloric nystagmus, hyperreflexia and hyporeflexia, NDP and PL altered; the findings were more prevalent and BIPVS EVN, and the caloric test the influence of ice withdrew NEOF in most individuals, enabling to reach a final conclusion.

  9. Asymptotic Freedom versus Open/Closed Duality in Large-N QCD

    CERN Document Server

    Bochicchio, Marco

    2016-01-01

    The solution of the large-N 't Hooft limit of QCD is universally believed to be a String Theory of Closed Strings in the Glueball Sector and of Open Strings in the Meson Sector. Yet, we prove a no-go theorem, that the large-N limit of QCD with massless quarks, or more generally, that the large-N limit of a vast class of confining, i.e. with a Mass Gap in the Glueball Sector, asymptotically-free Gauge Theories coupled to matter fields with no mass scale in perturbation theory cannot be a canonically-defined String Theory of Closed and Open Strings, i.e. admitting Open/Closed Duality. The no-go theorem occurs because Open/Closed Duality, implying that the ultraviolet divergences of annulus diagrams in the Open Sector arise from infrared divergences of tadpoles of massless particles in the Closed Sector, turns out to be incompatible with the existence of the Mass Gap in the Glueball Sector of confining asymptotically-free theories with no mass scale in perturbation theory in which, as for example in QCD, the fir...

  10. Observing lysozyme's closing and opening motions by high-resolution single-molecule enzymology.

    Science.gov (United States)

    Akhterov, Maxim V; Choi, Yongki; Olsen, Tivoli J; Sims, Patrick C; Iftikhar, Mariam; Gul, O Tolga; Corso, Brad L; Weiss, Gregory A; Collins, Philip G

    2015-06-19

    Single-molecule techniques can monitor the kinetics of transitions between enzyme open and closed conformations, but such methods usually lack the resolution to observe the underlying transition pathway or intermediate conformational dynamics. We have used a 1 MHz bandwidth carbon nanotube transistor to electronically monitor single molecules of the enzyme T4 lysozyme as it processes substrate. An experimental resolution of 2 μs allowed the direct recording of lysozyme's opening and closing transitions. Unexpectedly, both motions required 37 μs, on average. The distribution of transition durations was also independent of the enzyme's state: either catalytic or nonproductive. The observation of smooth, continuous transitions suggests a concerted mechanism for glycoside hydrolysis with lysozyme's two domains closing upon the polysaccharide substrate in its active site. We distinguish these smooth motions from a nonconcerted mechanism, observed in approximately 10% of lysozyme openings and closings, in which the enzyme pauses for an additional 40-140 μs in an intermediate, partially closed conformation. During intermediate forming events, the number of rate-limiting steps observed increases to four, consistent with four steps required in the stepwise, arrow-pushing mechanism. The formation of such intermediate conformations was again independent of the enzyme's state. Taken together, the results suggest lysozyme operates as a Brownian motor. In this model, the enzyme traces a single pathway for closing and the reverse pathway for enzyme opening, regardless of its instantaneous catalytic productivity. The observed symmetry in enzyme opening and closing thus suggests that substrate translocation occurs while the enzyme is closed.

  11. The epidemiology of Open Globe Injuries presenting to a tertiary referral eye hospital in Australia.

    Science.gov (United States)

    Beshay, Nader; Keay, Lisa; Dunn, Hamish; Kamalden, Tengku A; Hoskin, Annette K; Watson, Stephanie L

    2017-07-01

    Open globe injuries (OGIs) account for 44% of the cost of ocular trauma within Australia. It is estimated that 90% of ocular trauma is preventable. However, there have been few epidemiological studies within Australia that have identified groups at risk of OGIs specifically. The aim of our study was to review the epidemiology of OGIs presenting to a tertiary referral eye hospital in Australia. The Birmingham Eye Trauma Terminology (BETT) system was used to classify injuries as globe ruptures, penetrating eye injuries (PEIs), intraocular foreign bodies (IOFBs) or perforating injuries. Demographic data, past ocular history, mechanism of trauma, ocular injuries, and best-corrected visual acuity (BCVA) before and after treatment were recorded. The 205 OGIs included 80 globe ruptures, 71 PEIs, 48 IOFBs and six perforating injuries. Falls predominated in older age groups compared to the other mechanisms of injury (pglobe ruptures and 82% of these had a history of previous intraocular surgery. Globe rupture and perforating injuries had poorer visual outcomes (pGlobe ruptures occurring after a fall often had a history of intraocular surgery. The initial BCVA is useful for non-ophthalmologists who are unfamiliar with the ocular trauma score to help predict the BCVA following treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. A Platform for Closing the Open Data Feedback Loop Based on Web2.0 Functionality

    Directory of Open Access Journals (Sweden)

    Charalampos Alexopoulos

    2014-11-01

    Full Text Available One essential element of open data ecosystems concerns their development through feedback loops, discussions and dynamic supplier and user interactions. These user-centric features communicate the users’ needs to the open data community as well to the public sector bodies responsible for data publication. Addressing these needs by the corresponding public sector bodies or even by utilising the power of the community as ENGAGE supports will actually accelerate innovation. However, these elements appear barely to be part of existing open data practices. We conducted a survey which showed that most professional open data users did not know at least one open data infrastructure that enabled five specific types of discussion and feedback mechanisms. The survey showed that much can still be done to improve feedback and discussion on open data infrastructures. In this paper we discuss an open data platform which has started to contribute to filling this gap and present a usage scenario explaining the sequence of the underlined functionality. The discussed ENGAGE open data infrastructure combines functionalities to close the feedback loop and to return information to public authorities for better open data use and publication as well as establishing communication channels between stakeholders. This may effectively lead to the stimulation and facilitation of value generation from open data, as such functionality position the user at the centre of the open data publication process.

  13. Development of a prototype Open-close positron emission tomography system

    Science.gov (United States)

    Yamamoto, Seiichi; Okumura, Satoshi; Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu; Toshito, Toshiyuki; Komori, Masataka; Ogata, Yoshimune; Kato, Katsuhiko; Hatazawa, Jun

    2015-08-01

    We developed a prototype positron emission tomography (PET) system based on a new concept called Open-close PET, which has two modes: open and close-modes. In the open-mode, the detector ring is separated into two halved rings and subject is imaged with the open space and projection image is formed. In the close-mode, the detector ring is closed to be a regular circular ring, and the subject can be imaged without an open space, and so reconstructed images can be made without artifacts. The block detector of the Open-close PET system consists of two scintillator blocks that use two types of gadolinium orthosilicate (GSO) scintillators with different decay times, angled optical fiber-based image guides, and a flat panel photomultiplier tube. The GSO pixel size was 1.6 × 2.4 × 7 mm and 8 mm for fast (35 ns) and slow (60 ns) GSOs, respectively. These GSOs were arranged into an 11 × 15 matrix and optically coupled in the depth direction to form a depth-of-interaction detector. The angled optical fiber-based image guides were used to arrange the two scintillator blocks at 22.5° so that they can be arranged in a hexadecagonal shape with eight block detectors to simplify the reconstruction algorithm. The detector ring was divided into two halves to realize the open-mode and set on a mechanical stand with which the distance between the two parts can be manually changed. The spatial resolution in the close-mode was 2.4-mm FWHM, and the sensitivity was 1.7% at the center of the field-of-view. In both the close- and open-modes, we made sagittal (y-z plane) projection images between the two halved detector rings. We obtained reconstructed and projection images of 18F-NaF rat studies and proton-irradiated phantom images. These results indicate that our developed Open-close PET is useful for some applications such as proton therapy as well as other applications such as molecular imaging.

  14. Development of a prototype Open-close positron emission tomography system

    Energy Technology Data Exchange (ETDEWEB)

    Yamamoto, Seiichi, E-mail: s-yama@met.nagoya-u.ac.jp; Okumura, Satoshi; Komori, Masataka; Ogata, Yoshimune; Kato, Katsuhiko [Department of Radiological and Medical Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya (Japan); Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu [Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka (Japan); Toshito, Toshiyuki [Department of Proton Therapy Physics, Nagoya Proton Therapy Center, Nagoya City West Medical Center, Nagoya (Japan); Hatazawa, Jun [Department of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka (Japan); Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka (Japan)

    2015-08-15

    We developed a prototype positron emission tomography (PET) system based on a new concept called Open-close PET, which has two modes: open and close-modes. In the open-mode, the detector ring is separated into two halved rings and subject is imaged with the open space and projection image is formed. In the close-mode, the detector ring is closed to be a regular circular ring, and the subject can be imaged without an open space, and so reconstructed images can be made without artifacts. The block detector of the Open-close PET system consists of two scintillator blocks that use two types of gadolinium orthosilicate (GSO) scintillators with different decay times, angled optical fiber-based image guides, and a flat panel photomultiplier tube. The GSO pixel size was 1.6 × 2.4 × 7 mm and 8 mm for fast (35 ns) and slow (60 ns) GSOs, respectively. These GSOs were arranged into an 11 × 15 matrix and optically coupled in the depth direction to form a depth-of-interaction detector. The angled optical fiber-based image guides were used to arrange the two scintillator blocks at 22.5° so that they can be arranged in a hexadecagonal shape with eight block detectors to simplify the reconstruction algorithm. The detector ring was divided into two halves to realize the open-mode and set on a mechanical stand with which the distance between the two parts can be manually changed. The spatial resolution in the close-mode was 2.4-mm FWHM, and the sensitivity was 1.7% at the center of the field-of-view. In both the close- and open-modes, we made sagittal (y-z plane) projection images between the two halved detector rings. We obtained reconstructed and projection images of {sup 18}F-NaF rat studies and proton-irradiated phantom images. These results indicate that our developed Open-close PET is useful for some applications such as proton therapy as well as other applications such as molecular imaging.

  15. Development of a prototype Open-close positron emission tomography system.

    Science.gov (United States)

    Yamamoto, Seiichi; Okumura, Satoshi; Watabe, Tadashi; Ikeda, Hayato; Kanai, Yasukazu; Toshito, Toshiyuki; Komori, Masataka; Ogata, Yoshimune; Kato, Katsuhiko; Hatazawa, Jun

    2015-08-01

    We developed a prototype positron emission tomography (PET) system based on a new concept called Open-close PET, which has two modes: open and close-modes. In the open-mode, the detector ring is separated into two halved rings and subject is imaged with the open space and projection image is formed. In the close-mode, the detector ring is closed to be a regular circular ring, and the subject can be imaged without an open space, and so reconstructed images can be made without artifacts. The block detector of the Open-close PET system consists of two scintillator blocks that use two types of gadolinium orthosilicate (GSO) scintillators with different decay times, angled optical fiber-based image guides, and a flat panel photomultiplier tube. The GSO pixel size was 1.6 × 2.4 × 7 mm and 8 mm for fast (35 ns) and slow (60 ns) GSOs, respectively. These GSOs were arranged into an 11 × 15 matrix and optically coupled in the depth direction to form a depth-of-interaction detector. The angled optical fiber-based image guides were used to arrange the two scintillator blocks at 22.5° so that they can be arranged in a hexadecagonal shape with eight block detectors to simplify the reconstruction algorithm. The detector ring was divided into two halves to realize the open-mode and set on a mechanical stand with which the distance between the two parts can be manually changed. The spatial resolution in the close-mode was 2.4-mm FWHM, and the sensitivity was 1.7% at the center of the field-of-view. In both the close- and open-modes, we made sagittal (y-z plane) projection images between the two halved detector rings. We obtained reconstructed and projection images of (18)F-NaF rat studies and proton-irradiated phantom images. These results indicate that our developed Open-close PET is useful for some applications such as proton therapy as well as other applications such as molecular imaging.

  16. Tongues, bottles, and disconnected loops: The opening and closing of the interplanetary magnetic field

    Energy Technology Data Exchange (ETDEWEB)

    McComas, D.J. [Los Alamos National Lab., NM (United States). Space and Atmospheric Sciences Group

    1994-06-01

    For years the field of Space Physics has had a problem, a really big problem for it occurs on the largest spatial scales in Space physics -- across the entire region under the Sun`s influence, the heliosphere. The problem is that the Sun appears to keep opening new magnetic flux into interplanetary space with no obvious way for this flux to close back off again. This state of affairs, without some previously unknown method for closing the open interplanetary magnetic field (IMF), leads to an ever growing amount of magnetic flux in interplanetary space: the magnetic flux catastrophe. Recently, considerable progress has been made in understanding why this catastrophic state is not the observed state of the heliosphere. This brief article paints the newly emerging picture of the opening and closing of the IMF and how these processes may account for the observed variation in the amount of magnetic flux in interplanetary space over the solar cycle.

  17. In vitro eye irritation testing using the open source reconstructed hemicornea - a ring trial.

    Science.gov (United States)

    Mewes, Karsten R; Engelke, Maria; Zorn-Kruppa, Michaela; Bartok, Melinda; Tandon, Rashmi; Brandner, Johanna M; Petersohn, Dirk

    2017-01-01

    The aim of the present ring trial was to test whether two new methodological approaches for the in vitro classification of eye irritating chemicals can be reliably transferred from the developers' laboratories to other sites. Both test methods are based on the well-established open source reconstructed 3D hemicornea models. In the first approach, the initial depth of injury after chemical treatment in the hemicornea model is derived from the quantitative analysis of histological sections. In the second approach, tissue viability, as a measure for corneal damage after chemical treatment, is analyzed separately for epithelium and stroma of the hemicornea model. The three independent laboratories that participated in the ring trial produced their own hemicornea models according to the test producer's instructions, thus supporting the open source concept. A total of 9 chemicals with different physicochemical and eye-irritating properties were tested to assess the between-laboratory reproducibility (BLR), the predictive performance, as well as possible limitations of the test systems. The BLR was 62.5% for the first and 100% for the second method. Both methods enabled to discriminate Cat. 1 chemicals from all non-Cat. 1 substances, which qualifies them to be used in a top-down approach. However, the selectivity between No Cat. and Cat. 2 chemicals still needs optimization.

  18. Visual outcome and rotational stability of open loop toric intraocular lens implantation in Indian eyes

    Directory of Open Access Journals (Sweden)

    Arvind Venkataraman

    2013-01-01

    Full Text Available Purpose: To assess the visual outcome and rotational stability of single-piece open loop toric Intra Ocular Lens (IOL in a clinical setting. Materials and Methods: In a prospective study, 122 eyes of 77 patients were followed up for a period of 12 months after cataract surgery with toric open loop IOL implantation. The pre-operative markings for the position of incision and IOL placement were done under slit lamp by anterior stromal puncture. The visual acuity, refraction, and IOL position were assessed at day 1, 1 week, 1 month, 3 months, 6 months, and 12 months after surgery. Results: The mean age of the cohort was 56 yrs (S.D. 13.88; range 16 to 87 years. The mean pre-operative cylinder of corneal astigmatism was 1.37 D. (SD 0.79, range 1.0 to 5.87 D. Mean post-operative refractive cylinder was 0.36 D (SD 0.57, range 0 to 1.50 D at 12 months. Ninety-seven percent of the eyes were within 1 D of residual astigmatism. Ninety-four percent of patients had uncorrected visual acuity of 20/30 or better. Four eyes required IOL repositioning due to rotation. At 12 months, 96.7% of the IOLs were within 10 degrees of the target axis. There was no rotation seen after 6 months. Conclusion: Toric IOLs are very effective and consistent in correcting astigmatism during the cataract surgery. IOL rotation happens mostly within a month of surgery, and if significant, requires early repositioning.

  19. Geometry of elytra opening and closing in some beetles (Coleoptera, Polyphaga).

    Science.gov (United States)

    Frantsevich, Leonid; Dai, Zhendong; Wang, Wei Ying; Zhang, Yafeng

    2005-08-01

    Elytra in beetles move actively, driven by their own muscles, only during transient opening and closing. The kinematics of these movements have been inadequately described, sometimes controversially. Our goal was a quantitative 3-D description of diverse active movements of the elytra, in terms of directions of the axes of elytra rotation. Broad opening and closing was video recorded in beetles, tethered by the mesothorax, and has been analyzed frame by frame. For tracing, small dots or straw arms were glued to the elytra. Opening and closing traces coincided. The trace of the elytron apex was a flat circular arc about the axis of abduction-adduction (AAA). The rising hemiaxis pointed contralaterad. The AAA was tilted forwards in Melolontha hippocastani, Allomyrina dichotoma and Prionus coriarius but backwards in Chalcophora mariana. In Cetonia aurata, the AAA had a low elevation and a strong backward orientation. If another elytra-fixed point was traced in addition to the apex (in M. hippocastani and P. coriarius), then secondary rotation about the sutural edge (supination on opening) occurred. Modeling of abduction-adduction revealed that the elytron rose on opening if the AAA pointed contralaterad. The more the AAA was tilted forward, the more negative was the attack angle of the open elytra. The negative attack angle was partly compensated by positive body pitch and, more effectively, by supination of the costal edge about the sutural edge. The initial stage of opening included elevation of closed elytra (by 10-12 degrees) and partition to the sides, combined with an inward turn (<2-3 degrees). Axis of rotation at this stage presumably coincided with the AAA. Movement of one elytron with respect to the opposite one at the beginning of opening followed the shallow arc convex down. The geometry of this relative movement describes the initial partition of the elytra and release of the sutural lock.

  20. An open-plus-closed-loop control for chaotic Mathieu-Duffing oscillator

    Institute of Scientific and Technical Information of China (English)

    Jian-he SHEN; Shu-hui CHEN

    2009-01-01

    By using the idea of open-plus-closed-loop(OPCL) control, a controller com-posed of an external excitation and a linear feedback is designed to entrain chaotic tra-jectories of Mathieu-Duffing oscillator to its periodic and higher periodic orbits. The global basin of entrainment of this open-plus-closed-loop control is proved by combining the Lyapunov stability theory with a comparative theorem of initial value problems for second-order ordinary differential equations. Numerical simulations are performed to ver-ify the theoretical results.

  1. A unified Lie systems theory for closed and open Markovian dynamical quantum systems

    Energy Technology Data Exchange (ETDEWEB)

    Schulte-Herbrueggen, Thomas [Technical University of Munich (TUM) (Germany); Dirr, Gunther [University of Wuerzburg (Germany)

    2016-07-01

    Lie groups and Lie semigroups with their symmetries provide a unified framework to pinpoint the dynamic behaviour of closed and open quantum systems under all kinds of controls. Recently, we showed that all Markovian quantum maps can be represented by Lie semigroups. These semigroups come with the geometry of affine maps, whose translational parts determine the respective fixed points. We exploit this geometry for dissipative fixed-point engineering of unique target states be they pure or mixed. We extend capabilities by combining coherent control with simplest noise controls. Particular light is shed on reachability and open-loop versus closed-loop control design.

  2. Life Cycle Assessment of Farmed Salmon, Comparing a Closed with an Open Sea Cage System

    OpenAIRE

    2014-01-01

    Ole Jonny Nyhus, Marine Technology, Norwegian University of Science and Technology.Abstract of Master's Thesis, levert 8. juni, 2014:Life Cycle Assessment of Farmed Salmon, Comparing a Closed with an Open Sea Cage System.The goal of this Master's Thesis is to do a Life Cycle Assessment (LCA) on a closed fish farm system and compare it to an open fish farm system, for so to make recommendations based on the results.Life Cycle Assessment is a method to calculate the environmental impa...

  3. Tandem Ring-Opening-Ring-Closing Metathesis for Functional Metathesis Catalysts.

    Science.gov (United States)

    Nagarkar, Amit A; Yasir, Mohammad; Crochet, Aurelien; Fromm, Katharina M; Kilbinger, Andreas F M

    2016-09-26

    Use of a tandem ring-opening-ring-closing metathesis (RORCM) strategy for the synthesis of functional metathesis catalysts is reported. Ring opening of 7-substituted norbornenes and subsequent ring-closing metathesis forming a thermodynamically stable 6-membered ring lead to a very efficient synthesis of new catalysts from commercially available Grubbs' catalysts. Hydroxy functionalized Grubbs' first- as well as third-generation catalysts have been synthesized. Mechanistic studies have been performed to elucidate the order of attack of the olefinic bonds. This strategy was also used to synthesize the ruthenium methylidene complex.

  4. Open-loop versus closed-loop control of MEMS devices: choices and issues

    Science.gov (United States)

    Borovic, B.; Liu, A. Q.; Popa, D.; Cai, H.; Lewis, F. L.

    2005-10-01

    From a controls point of view, micro electromechanical systems (MEMS) can be driven in an open-loop and closed-loop fashion. Commonly, these devices are driven open-loop by applying simple input signals. If these input signals become more complex by being derived from the system dynamics, we call such control techniques pre-shaped open-loop driving. The ultimate step for improving precision and speed of response is the introduction of feedback, e.g. closed-loop control. Unlike macro mechanical systems, where the implementation of the feedback is relatively simple, in the MEMS case the feedback design is quite problematic, due to the limited availability of sensor data, the presence of sensor dynamics and noise, and the typically fast actuator dynamics. Furthermore, a performance comparison between open-loop and closed-loop control strategies has not been properly explored for MEMS devices. The purpose of this paper is to present experimental results obtained using both open- and closed-loop strategies and to address the comparative issues of driving and control for MEMS devices. An optical MEMS switching device is used for this study. Based on these experimental results, as well as computer simulations, we point out advantages and disadvantages of the different control strategies, address the problems that distinguish MEMS driving systems from their macro counterparts, and discuss criteria to choose a suitable control driving strategy.

  5. Conformational changes opening and closing the CFTR chloride channel: insights from cysteine scanning mutagenesis.

    Science.gov (United States)

    El Hiani, Yassine; Linsdell, Paul

    2014-12-01

    Cystic fibrosis, the most common lethal genetic disease affecting young people in North America, is caused by failure of the chloride ion channel known as CFTR (cystic fibrosis transmembrane conductance regulator). CFTR belongs to the large family of ATP-binding cassette (ABC) membrane transporters. In CFTR, ATP-driven events at the nucleotide-binding domains (NBDs) open and close a gate that controls chloride permeation. However, the conformational changes concomitant with opening and closing of the CFTR gate are unknown. Diverse techniques including substituted cysteine accessibility method, disulfide cross-linking, and patch-clamp recording have been used to explore CFTR channel structure. Here, we consider the architecture of both the open and the closed CFTR channel. We review how CFTR channel structure changes between the closed and the open channel conformations and portray the relative function of both cytoplasmic and vestigial gates during the gating cycle. Understanding how the CFTR channel gates chloride permeation is central for understanding how CFTR defects lead to CF. Such knowledge opens the door for novel ways to maximize CFTR channel activity in a CF setting.

  6. Closed and Open Loop Subspace System Identification of the Kalman Filter

    Directory of Open Access Journals (Sweden)

    David Di Ruscio

    2009-04-01

    Full Text Available Some methods for consistent closed loop subspace system identification presented in the literature are analyzed and compared to a recently published subspace algorithm for both open as well as for closed loop data, the DSR_e algorithm. Some new variants of this algorithm are presented and discussed. Simulation experiments are included in order to illustrate if the algorithms are variance efficient or not.

  7. Comparison of flux measurement by open-path and close-path eddy covariance systems

    Institute of Scientific and Technical Information of China (English)

    SONG; Xia; YU; Guirui; LIU; Yunfen; SUN; Xiaomin; REN; Chua

    2005-01-01

    For flux measurement, the eddy covariance technique supplies a possibility to directly measure the exchange between vegetation and atmosphere; and there are two kinds of eddy covariance systems, open-path and close-path systems. For the system error, it may result in difference of flux measurements by two systems. Therefore, it is necessary to compare the measured results from them. ChinaFLUX covers of eight sites applied the micrometeorological method, in which Changbai Mountains (CBS) and Qianyanzhou (QYZ) carried out open-path eddy covariance (OPEC) and close-path eddy covariance (CPEC) measurements synchronously.In this paper the data sets of CBS and QYZ were employed. The delay time of close-path analyzer to the open-path analyzer was calculated; the spectra and cospectra of time-series data of OPEC and CPEC were analyzed; the open-path flux measurement was used as a standard comparison, the close-path flux measurement results were evaluated. The results show that, at two sites the delay time of CO2 density for close-path analyzer was about 7.0-8.0 s, H2O density about 8.0-9.0 s; the spectrum from the open-path, close-path and 3D sonic anemometer was consistent with the expected -2/3 slope (log-log plot), and the cospectra showed the expected slope of -4/3 in the internal subrange; the CO2 flux measured by the close-path sensor was about 84% of that of open-path measurement at QYZ, about 80% at CBS, and the latent heat flux was balanced for two systems at QYZ, 86% at CBS. From the flux difference between open-path and close-path analyzers, it could be inferred that the attenuation of turbulent fluctuations in flow through tube of CPEC affected H2O flux more significantly than CO2 flux. The gap between two systems was bigger at CBS than at QYZ; the diurnal variation in CO2 flux of two measurement systems was very consistent.

  8. Morphing structures of the Dionaea muscipula Ellis during the trap opening and closing.

    Science.gov (United States)

    Volkov, Alexander G; Forde-Tuckett, Victoria; Volkova, Maya I; Markin, Vladislav S

    2014-01-01

    The Venus flytrap is a marvelous plant that has intrigued scientists since the times of Charles Darwin. This carnivorous plant is capable of very fast movements to catch a prey. We found that the maximal speed of the trap closing in the Dionaea muscipula Ellis is about 130,000 times faster than the maximal speed of the trap opening. The mechanism and kinetics of this movement was debated for a long time. Here, the most recent Hydroelastic Curvature Model is applied to the analysis of this movement during closing and opening of the trap with or without a prey. Equations describing the trap movement were derived and verified with experimental data. Chloroform and ether, both anesthetic agents, induce action potentials and close the trap without the mechanical stimulation of trigger hairs. We tested this by dropping 10 μL of ether on the midrib inside the trap without touching any of the mechanosensitive trigger hairs. The trap closed slowly in 10 s. This is at least 20 times slower than the closing of the trap mechanically or electrically. The similar effect can be induced by placing 10 μL of chloroform on the midrib inside the trap, however, the lobes closing time in this case is as fast as closing after mechanical stimulation of the trigger hairs.

  9. IDENTIFICATION OF BOTH CLOSED- AND OPEN-LOOP STOCHASTIC SYSTEM WHILE STABILIZING IT

    Institute of Scientific and Technical Information of China (English)

    CHEN Hanfu (Han-Fu Chen)

    2002-01-01

    This paper proposes a recursive algorithm estimating coefficients of thc linear stochastic control system (ARX system) driven by a martingale difference sequence, while adaptively stabilizing the system without introducing external excitation signal. The system is allowed to be unstable and of nonminimum-phase. The estimates derived for the coefficients of both closed-loop and open-loop systems are strongly consistent.

  10. The 'French Fry' VAC technique: hybridisation of traditional open wound NPWT with closed incision NPWT.

    Science.gov (United States)

    Chopra, Karan; Tadisina, Kashyap K; Singh, Devinder P

    2016-04-01

    Surgical site occurrences (SSO), specifically surgical site infections represent a significant burden in the US health care system. It has been hypothesised that postoperative dressing can help drive down SSO. We describe the successful use of a novel technique combining both closed incision and open negative pressure wound therapy in the management of a high-risk wound associated with lymphoedema of obesity.

  11. More than "Hello" and "Bye-Bye": Opening and Closing the Online Chats in Mandarin Chinese

    Science.gov (United States)

    Zhang, De

    2014-01-01

    Reporting on a descriptive study on the first semester Chinese language learners' openings and closings in online chats with age-peer native speakers of Chinese, this paper demonstrates the great promise that telecollaboration holds for foreign language education, and argues for an increasing role of pragmatics in Chinese language…

  12. A general theoretical framework for decoherence in open and closed systems

    Science.gov (United States)

    Castagnino, Mario; Fortin, Sebastian; Laura, Roberto; Lombardi, Olimpia

    2008-08-01

    A general theoretical framework for decoherence is proposed, which encompasses formalisms originally devised to deal just with open or closed systems. The conditions for decoherence are clearly stated and the relaxation and decoherence times are compared. Finally, the spin-bath model is developed in detail from the new perspective.

  13. Metabolites, their decomposition, production of tomato and bioassays from open and closed rockwool systems

    NARCIS (Netherlands)

    Kreij, de C.; Runia, W.T.; Burg, van der A.M.M.

    2004-01-01

    Growth, decrease in yield and other, undefined problems are reported to be due to the recirculation of the nutrient solution, which is compulsory for crops grown on substrates in the Netherlands. In a trial with tomato grown on rockwool, open and closed systems were compared. Drain water from both s

  14. Induction of sperm activation in open and closed thelycum penaeoid shrimps

    NARCIS (Netherlands)

    Alfaro Montoya, J.; Munoz, N.; Vargas, M.; Komen, J.

    2003-01-01

    A modified egg water (EW) technique for in vitro induction of sperm activation was applied to Trachypenaeus byrdi, Xiphopenaeus riveti (closed thelycum shrimps), and Litopenaeus occidentalis (open thelycum) from a tropical estuary, Golfo de Nicoya, Costa Rica. The study was designed to investigate t

  15. A general theoretical framework for decoherence in open and closed systems

    Energy Technology Data Exchange (ETDEWEB)

    Castagnino, Mario [CONICET, IAFE, Instituto de Fisica de Rosario, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Casilla de Correos 67, Sucursal 28, 1428, Buenos Aires (Argentina); Fortin, Sebastian [CONICET, IAFE, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Casilla de Correos 67, Sucursal 28, 1428, Buenos Aires (Argentina); Laura, Roberto [Departamento de Fisica y Quimica, Facultad de Ciencias Exactas, IngenierIa y Agrimensura, Universidad Nacional de Rosario, Pellegrini 250, 2000, Rosario (Argentina); Lombardi, Olimpia [CONICET, Universidad de Buenos Aires, Crisologo Larralde 3440, 1430, Buenos Aires (Argentina)

    2008-08-07

    A general theoretical framework for decoherence is proposed, which encompasses formalisms originally devised to deal just with open or closed systems. The conditions for decoherence are clearly stated and the relaxation and decoherence times are compared. Finally, the spin-bath model is developed in detail from the new perspective.

  16. Implementation of Open and Closed Kinetic Chain Quadriceps Strengthening Exercises after Anterior Cruciate Ligament Reconstruction.

    Science.gov (United States)

    Ross, Michael D.; Denegar, Craig R.; Winzenried, Jay A.

    2001-01-01

    Reviews the effects of open kinetic chain (OKC) and closed kinetic chain (CKC) exercise on anterior cruciate ligament (ACL) strain and patellofemoral joint stress, suggesting a combination of the two for quadriceps strengthening after ACL reconstruction. Both OKC and CKC exercises may be modified and implemented for quadriceps strengthening after…

  17. More than "Hello" and "Bye-Bye": Opening and Closing the Online Chats in Mandarin Chinese

    Science.gov (United States)

    Zhang, De

    2014-01-01

    Reporting on a descriptive study on the first semester Chinese language learners' openings and closings in online chats with age-peer native speakers of Chinese, this paper demonstrates the great promise that telecollaboration holds for foreign language education, and argues for an increasing role of pragmatics in Chinese language instruction, and…

  18. The effects and safety of closed versus open tracheal suction system:a meta analysis

    Institute of Scientific and Technical Information of China (English)

    董亮

    2012-01-01

    Objective To evaluate the effects and safety of closed tracheal suction system (CTSS) versus open tracheal suction system(OTSS) for mechanically ventilated patients. Methods All randomized controlled trials (RCTs) comparing CTSS with OTSS for mechanically ventilated patients home and abroad

  19. More than "Hello" and "Bye-Bye": Opening and Closing the Online Chats in Mandarin Chinese

    Science.gov (United States)

    Zhang, De

    2014-01-01

    Reporting on a descriptive study on the first semester Chinese language learners' openings and closings in online chats with age-peer native speakers of Chinese, this paper demonstrates the great promise that telecollaboration holds for foreign language education, and argues for an increasing role of pragmatics in Chinese language instruction, and…

  20. Designing EEG Neurofeedback Procedures to Enhance Open-Ended versus Closed-Ended Creative Potentials

    Science.gov (United States)

    Lin, Wei-Lun; Shih, Yi-Ling

    2016-01-01

    Recent empirical evidence demonstrated that open-ended creativity (which refers to creativity measures that require various and numerous responses, such as divergent thinking) correlated with alpha brain wave activation, whereas closed-ended creativity (which refers to creativity measures that ask for one final correct answer, such as insight…

  1. Open Versus Closed Hearing-Aid Fittings: A Literature Review of Both Fitting Approaches.

    Science.gov (United States)

    Winkler, Alexandra; Latzel, Matthias; Holube, Inga

    2016-02-15

    One of the main issues in hearing-aid fittings is the abnormal perception of the user's own voice as too loud, "boomy," or "hollow." This phenomenon known as the occlusion effect be reduced by large vents in the earmolds or by open-fit hearing aids. This review provides an overview of publications related to open and closed hearing-aid fittings. First, the occlusion effect and its consequences for perception while using hearing aids are described. Then, the advantages and disadvantages of open compared with closed fittings and their impact on the fitting process are addressed. The advantages include less occlusion, improved own-voice perception and sound quality, and increased localization performance. The disadvantages associated with open-fit hearing aids include reduced benefits of directional microphones and noise reduction, as well as less compression and less available gain before feedback. The final part of this review addresses the need for new approaches to combine the advantages of open and closed hearing-aid fittings.

  2. Effects of open and closed suction systems on the haemodynamic parameters in cardiac surgery patients.

    Science.gov (United States)

    Özden, Dilek; Görgülü, Refia S

    2015-05-01

    This study was carried out to determine the effects of open and closed suction systems on haemodynamic parameters of the patients who underwent open heart surgery. Nurses should work meticulously and carefully as many complications may develop if the method used to perform suctioning is not appropriate. The quasi-experimental study design was used. The study sample comprised 120 patients who underwent open heart surgery in the cardiovascular surgery intensive care unit of a state hospital in Turkey. Haemodynamic parameters were determined just before, right after, at the 5th and 15th minute after suctioning. The data were evaluated with the One-Way Analysis of Variance (ANOVA) for Repeated Measures, independent t-test and Bonferroni's test for further analysis (post hoc). The difference between heart rate (HR) and mean blood pressure, mean PaO2 and PaCO2 , SaO2 and pH values measured before, right after and at the 5th and 15th minute after suctioning was found to be significant in patients who underwent the open suctioning procedure. It was determined that the difference between mean PaO2 values was not significant and that SaO2 versus SpO2 values increased in patients who underwent the closed suctioning procedure. When the open and closed suction systems were compared, statistically significant difference was determined in terms of MAP, SpO2 . It was determined that HR, arterial blood pressure and arterial blood gases of the patients who underwent open heart surgery were negatively affected by the open suction system but did not increase significantly as soon as suctioning was over during the closed suctioning procedure. The data obtained indicate that closed system suctioning, compared with open system suctioning, can be used safely on this patient group. The closed suction system is recommended since it contributes to the enhancement of patient safety and the quality of nursing care. © 2014 The Authors. Nursing in Critical Care published by John Wiley & Sons

  3. An optimal open/closed-loop control method with application to a pre-stressed thin duralumin plate

    Science.gov (United States)

    Nadimpalli, Sruthi Raju

    The excessive vibrations of a pre-stressed duralumin plate, suppressed by a combination of open-loop and closed-loop controls, also known as open/closed-loop control, is studied in this thesis. The two primary steps involved in this process are: Step (I) with an assumption that the closed-loop control law is proportional, obtain the optimal open-loop control by direct minimization of the performance measure consisting of energy at terminal time and a penalty on open-loop control force via calculus of variations. If the performance measure also involves a penalty on closed-loop control effort then a Fourier based method is utilized. Step (II) the energy at terminal time is minimized numerically to obtain optimal values of feedback gains. The optimal closed-loop control gains obtained are used to describe the displacement and the velocity of open-loop, closed-loop and open/closed-loop controlled duralumin plate.

  4. Analysis of voltage unbalance effects on induction motors with open and closed slots

    Energy Technology Data Exchange (ETDEWEB)

    Donolo, Pablo, E-mail: pdonolo@gmail.co [Grupo de Electronica Aplicada, Fac. de Ingenieria, Universidad Nacional de Rio Cuarto, Ruta Nac. 36 Km 601 (X5804BYA), Rio Cuarto, Cordoba (Argentina); Bossio, Guillermo, E-mail: gbossio@ieee.or [Grupo de Electronica Aplicada, Fac. de Ingenieria, Universidad Nacional de Rio Cuarto, Ruta Nac. 36 Km 601 (X5804BYA), Rio Cuarto, Cordoba (Argentina); De Angelo, Cristian, E-mail: cdeangelo@ieee.or [Grupo de Electronica Aplicada, Fac. de Ingenieria, Universidad Nacional de Rio Cuarto, Ruta Nac. 36 Km 601 (X5804BYA), Rio Cuarto, Cordoba (Argentina)

    2011-05-15

    Research highlights: {yields} We study the increase of losses in the induction motor (IM) with voltage unbalance. {yields} We take into account the variations in the negative-sequence impedance of the rotor. {yields} We analyze the performance in IM with open and closed rotor slots. {yields} For both type of rotors, we get the derating factor for different levels of unbalance. {yields} IM with closed-slot are less affected by voltage unbalance than open-slot ones. -- Abstract: This paper aims to complement studies concerning the influence of voltage unbalance on the performance of induction motors. We use sequence equivalent circuits to determine the increase of losses in the induction motor. We take into account the dependence of the rotor negative-sequence reactance with the load state and the increase in rotor resistance with the negative-sequence currents. Variations in the negative-sequence impedance are related with the structural characteristics of the rotor. We analyze motors with open and closed rotor slots, because the impedance of rotors with closed slots grows considerably when the load is less than rated, producing lower negative-sequence currents and lower losses. Increased rotor impedance in closed slot motors protects these motors against problems due to unbalanced supply voltage. For both type of rotors, we analyze motor derating factor based on voltage unbalance and increases in total losses and rotor losses.

  5. Survey and comparison for Open and closed sources in cloud computing

    Directory of Open Access Journals (Sweden)

    Nadir Kamal Salih

    2012-05-01

    Full Text Available Cloud computing is a new technology widely studied in recent years. Now there are many cloud platforms both in industry and in academic circle. How to understand and use these platforms is a big issue. A detailed comparison has been presented in this paper focused on the aspects such as the architecture, characteristics, application and so on. To know the differences between open source and close source in cloud environment we mention some examples for Software-as-a-Service, Platform-as-a-Service, and Infrastructure-as-a-Service. We made comparison between them. Before conclusion we demonstrate some convergences and differences between open and closed platform, but we realized open source should be the best option

  6. Bifurcations of limit cycles in open and closed loop reverse flow reactors

    Science.gov (United States)

    Russo, Lucia; Crescitelli, Silvestro; Brasiello, Antonio

    2013-10-01

    The present work analyses the bifurcations of limit cycles in open and loop reverse flow reactors. The open loop system consists of a reactor where the flow direction is periodically forced whereas in the closed loop system, the flow inversion is dictated by a control law which activates when the temperature at the edge of catalytic bed falls below the set-point value. We performed the bifurcation analysis of the open loop system as the switch time is varied and we constructed the solution diagram through the application of continuation technique. Many Naimark-Sacker bifurcations leading to quasi-periodic regimes have been found on the limit cycles branches. Finally, we compared these limit cycles with those of the closed loop system where the flow inversion is dictated by a control system which acts if the temperature measured at the edge of reactor falls below a set-point value.

  7. Open- and closed-loop multiobjective optimal strategies for HIV therapy using NSGA-II.

    Science.gov (United States)

    Heris, S Mostapha Kalami; Khaloozadeh, Hamid

    2011-06-01

    In this paper, multiobjective open- and closed-loop optimal treatment strategies for HIV/AIDS are presented. It is assumed that highly active antiretroviral therapy is available for treatment of HIV infection. Amount of drug usage and the quality of treatment are defined as two objectives of a biobjective optimization problem, and Nondominated Sorting Genetic Algorithm II is used to solve this problem. Open- and closed-loop control strategies are used to produce optimal control inputs, and the Pareto frontiers obtained from these two strategies are compared. Pareto frontier, resulted from the optimization process, suggests a set of treatment strategies, which all are optimal from a perspective, and can be used in different medical and economic conditions. Robustness of closed-loop system in the presence of measurement noises is analyzed, assuming various levels of noise.

  8. Association of open-angle glaucoma loci with incident glaucoma in the Blue Mountains Eye Study.

    Science.gov (United States)

    Burdon, Kathryn P; Mitchell, Paul; Lee, Anne; Healey, Paul R; White, Andrew J R; Rochtchina, Elena; Thomas, Peter B M; Wang, Jie Jin; Craig, Jamie E

    2015-01-01

    To determine if open-angle glaucoma (OAG)-associated single nucleotide polymorphisms (SNPs) are associated with incident glaucoma and if such genetic information is useful in OAG risk prediction. Case-control from within a population-based longitudinal study. study population: Individuals aged over 49 years of age living in the Blue Mountains region west of Sydney and enrolled in the Blue Mountains Eye Study. observation: Cases for this sub-study (n = 67) developed incident OAG between baseline and 10-year visits, in either eye, while controls (n = 1919) had no evidence for OAG at any visit. All participants had an ocular examination and DNA genotyped for reported OAG risk SNPs. main outcome measure: Incident OAG. Two loci also known to be associated with cup-to-disc ratio as well as OAG (9p21 near CDKN2B-AS1 and SIX1/SIX6) were both significantly associated with incident OAG in the Blue Mountains Eye Study cohort (P = .006 and P = .004, respectively). The TMCO1 locus was nominally associated (P = .012), while the CAV1/CAV2 and 8q22 loci were not associated. Multivariate logistic regression and neural network analysis both indicated that the genetic risk factors contributed positively to the predictive models incorporating traditional risk factors. This study shows that previously reported genetic variations related to OAG and cup-to-disc ratio are associated with the onset of OAG and thus may become useful in risk prediction algorithms designed to target early treatment to those most at risk of developing glaucoma. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

  9. Open globe eye injury characteristics and prognostic factors in Jazan, Saudi Arabia.

    Science.gov (United States)

    Makhrash, Mashaal A; Gosadi, Ibrahim M

    2016-12-01

    To evaluate characteristics and prognostic factors of open globe injuries (OGI) presented to King Fahad Specialist Hospital in the Jazan region, Saudi Arabia.  Methods: This study is a retrospective review of medical records of OGI patients who underwent operative repair of their injuries in King Fahad Central Hospital, Jazan, Saudi Arabia between January 2011 and December 2013. Demographic information, eye injury, preoperative, and postoperative visual acuity were collected. The initial and final visual acuity outcomes were compared to identify subjects who witnessed any improvement in their visual acuity. Logistic regression was used to assess characteristics associated with improvements in the visual acuity.  Results: Number of included cases was 120. Most frequently reported causes of injury were blunt trauma (20%) and shattered glass (18.3%). Approximately half of the cases were reported to have iris injuries or hyphema. Most cases suffered penetration (37.5%) of the eye globe. Only zone I injury was significantly associated with better visual acuity outcomes (odds ratio [OR]: 2.447, p=0.036). Among the variables that were associated with poorer prognostic outcomes, only aphakia (OR: 0.180), retinal damage (OR: 0.062), vitreous hemorrhage (OR: 0.266), and zone III injuries (OR: 0.092) were statistically significant (p less than 0.05).     Conclusion: Zone I injury appears to have a better prognostic effect on visual acuity where injuries related to Zone III were associated with worse prognostic outcomes.

  10. Conservative whole-organ scaling contrasts with highly labile suborgan scaling differences among compound eyes of closely related Formica ants.

    Science.gov (United States)

    Perl, Craig D; Rossoni, Sergio; Niven, Jeremy E

    2017-03-01

    Static allometries determine how organ size scales in relation to body mass. The extent to which these allometric relationships are free to evolve, and how they differ among closely related species, has been debated extensively and remains unclear; changes in intercept appear common, but changes in slope are far rarer. Here, we compare the scaling relationships that govern the structure of compound eyes of four closely related ant species from the genus Formica. Comparison among these species revealed changes in intercept but not slope in the allometric scaling relationships governing eye area, facet number, and mean facet diameter. Moreover, the scaling between facet diameter and number was conserved across all four species. In contrast, facet diameters from distinct regions of the compound eye differed in both intercept and slope within a single species and when comparing homologous regions among species. Thus, even when species are conservative in the scaling of whole organs, they can differ substantially in regional scaling within organs. This, at least partly, explains how species can produce organs that adhere to genus wide scaling relationships while still being able to invest differentially in particular regions of organs to produce specific features that match their ecology.

  11. Application of innovative policies for controlling radionuclide releases: The {open_quotes}open-market trading rule{close_quotes}

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, D.W. [Dade Moeller & Associates, Inc., New Bern, NC (United States)

    1997-08-01

    In the past, most efforts for reducing airborne radio nuclide releases and controlling radioactive wastes have been directed to the development of new and improved technologies. Little attention has been paid to the possible application to these problems of new, innovative policies. Yet, experience in other fields shows that such applications could be beneficial. A prime example is the {open_quotes}open-market trading rule,{close_quotes} now being widely used in the U.S. for the control of a range of environmental problems. Through this rule, nuclear facility operators would be permitted to control airborne emissions in a more cost-effective manner, and those responsible for decommissioning and decontaminating nuclear facilities no longer in operation could do so at far lower costs while generating significantly smaller volumes of radioactive wastes. Application of such a policy would also significantly reduce the demands on existing, and the need for research to develop new, improved, control technologies. 16 refs.

  12. Comparison of Open and Closed Stance Forehand Strokes among Intermediate Tennis Players

    Directory of Open Access Journals (Sweden)

    Tajul Arifin Muhamad

    2016-01-01

    Full Text Available Background: Nowadays tennis is becoming faster and players are able to hit powerful from virtually anywhere on the tennis court. Training programmers and effective planning will help in designing safe, effective, and productive programs designed to help optimize the tennis performance of players. Objective: This research examine the effectiveness of open and closed stance forehand strokes in terms of percentage of success, accuracy and also to investigate whether there is a relation between level of accuracy and the choice of forehand strokes used by tennis player. Method: Participants were divided into two groups, namely, male and female who learned forehand strokes for one month. The participants were tested by using a two skill test for percentage of success and level of accuracy. Result: Founding showed that the closed stance forehand stroke has far better percentage of success and accuracy among the intermediate tennis players, but the difference was not significant. In addition, male players showed more accuracy and success in this research. And also accuracy did not have any influence to choice of forehand stroke among the intermediate tennis players. Conclusion: This research could improve the training protocol design for teaching the closed stance and open stance strokes. Keywords: Forehand stroke, open stance, closed stance, tennis accuracy, percentage of success

  13. Guided tooth eruption: Comparison of open and closed eruption techniques in labially impacted maxillary canines

    Directory of Open Access Journals (Sweden)

    S M londhe

    2014-01-01

    Full Text Available Background: After third molars, the maxillary canines are the most commonly impacted permanent teeth and one-third of these are labial impactions. Impacted canines often require orthodontic guidance in the eruption. This study was conducted to assess the posttreatment results of surgically exposed and orthodontically aligned labially impacted maxillary canines comparing two different surgical techniques. Materials and Methods: The study was conducted in two phases, a surgical phase and an orthodontic phase. In surgical phase, events during surgical exposure and recovery of 31 patients with labially impacted maxillary canine were recorded. Patients were managed with open and closed eruption technique. The assessment included comparison of two techniques of surgical exposure, postoperative pain, mobility, vitality, periodontal health, level of impaction, and duration of orthodontic treatment. Results: The postoperative recovery was longer after open eruption than close eruption technique (P = 0.000. Postoperative pain experienced by patients was similar, but regression of pain was faster in closed eruption technique. The mean surgical time for open eruption technique was lesser when compared with closed eruption technique (P = 0.000. The total duration of orthodontic treatment was directly dependent upon the level of impaction, with deeper level of impaction having longer duration of orthodontic treatment. The mobility and vitality of guided canine was similar in both techniques. Conclusion: The closed eruption technique was a longer surgical procedure, but the postoperative pain regression was faster. The duration of orthodontic treatment was longer with deeper level of impaction. The closed eruption surgical techniques provide better periodontal tissues around the guided erupted teeth.

  14. On closed-string twist-field correlators and their open-string descendants

    CERN Document Server

    Anastasopoulos, Pascal; Richter, Robert

    2011-01-01

    In a recent paper we have proposed the possibility that the lightest massive string states could be identified with open strings living at intersections of D-branes forming small angles. In this note, we reconsider the relevant twist-field correlation functions and perform the analysis of the sub-dominant physical poles in the various channels. Our derivation is new in that it is based on the algebraic procedure for the construction of open string models starting from their closed-string `parents' rather than on the stress-tensor method. We also indicate possible generalizations and diverse applications of our approach.

  15. Chemical and aerosol processes in the transition from closed to open cells during VOCALS-REx

    Directory of Open Access Journals (Sweden)

    J. Kazil

    2011-02-01

    Full Text Available Chemical and aerosol processes in the transition from closed- to open-cell circulation in the remote, cloudy marine boundary layer are explored. It has previously been shown that precipitation can initiate a transition from the closed- to the open-cellular state, but that the boundary layer cannot maintain this open-cell state without a resupply of cloud condensation nuclei (CCN. Potential sources include wind-driven production of sea salt particles from the ocean, nucleation from the gas phase, and entrainment from the free troposphere. In order to investigate aerosol sources in the marine boundary layer and their role in supplying new particles, we have coupled in detail chemical, aerosol, and cloud processes in the WRF/Chem model, and added state-of-the-art representations of sea salt emissions and aerosol nucleation. We introduce the new features of the model and conduct simulations of the marine boundary layer in the transition from a closed- to an open-cell state. Results are compared with observations in the Southeast Pacific boundary layer during the VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx. The transition from the closed- to the open-cell state generates conditions that are conducive to nucleation by forming a cloud-scavenged, ultra-clean layer below the inversion base. Open cell wall updrafts loft dimethyl sulfide from the ocean surface into the ultra-clean layer, where it is oxidized during daytime to SO2 and subsequently to H2SO4. Low H2SO4 condensation sink values in the ultra-clean layer allow H2SO4 to rise to concentrations at which aerosol nucleation proceeds efficiently. The existence of the ultra-clean layer is confirmed by observations. We find that the observed DMS flux from the ocean in the VOCALS-REx region can support a nucleation source of aerosol in open cells that exceeds sea salt emissions in terms of the number

  16. Irradiation Testing Vehicles for Fast Reactors from Open Test Assemblies to Closed Loops

    Energy Technology Data Exchange (ETDEWEB)

    Sienicki, James J. [Argonne National Lab. (ANL), Argonne, IL (United States); Grandy, Christopher [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-12-15

    A review of irradiation testing vehicle approaches and designs that have been incorporated into past Sodium-Cooled Fast Reactors (SFRs) or envisioned for incorporation has been carried out. The objective is to understand the essential features of the approaches and designs so that they can inform test vehicle designs for a future U.S. Fast Test Reactor. Fast test reactor designs examined include EBR-II, FFTF, JOYO, BOR-60, PHÉNIX, JHR, and MBIR. Previous designers exhibited great ingenuity in overcoming design and operational challenges especially when the original reactor plant’s mission changed to an irradiation testing mission as in the EBRII reactor plant. The various irradiation testing vehicles can be categorized as: Uninstrumented open assemblies that fit into core locations; Instrumented open test assemblies that fit into special core locations; Self-contained closed loops; and External closed loops. A special emphasis is devoted to closed loops as they are regarded as a very desirable feature of a future U.S. Fast Test Reactor. Closed loops are an important technology for irradiation of fuels and materials in separate controlled environments. The impact of closed loops on the design of fast reactors is also discussed in this report.

  17. Aladdin Sane and Close-Up Eye Asymmetry: David Bowie’s Contribution to Comic Book Visual Language

    Directory of Open Access Journals (Sweden)

    Igor Juricevic

    2017-03-01

    Full Text Available In April 1973 David Bowie released 'Aladdin Sane'. The cover of 'Aladdin Sane' features an iconic image of David Bowie, a close-up shot of the artist with brightly colored orange hair and asymmetrical lightning bolt make-up on the right side of his face. This article argues that the cover image for 'Aladdin Sane' uses the Close-Up Eye Asymmetry (CUE-A pictorial device (i.e., close-up view of David Bowie, asymmetrical make-up around his eye and that CUE-A was adopted into Comic Book Visual Language by first providing evidence that CUE-A is used in comic book art. A link is then established between comic book art and music album art by showing that: (1 David Bowie was familiar with Comic Book Visual Language and could make a contribution to the language, and (2 comic book artists are influenced by music album art. I then make a case that the adoption of CUE-A into Comic Book Visual Language was specifically due to the cover image for 'Aladdin Sane' by analyzing: (1 the use of CUE-A by influential artists in the 1990s and (2 the different rates of adoption of CUE-A for the depiction of established versus newer comic book characters.

  18. Relationship Between Peripapillary Atrophy and Optic Disc Parameters in Eyes with Primary Open-Angle Glaucoma

    Directory of Open Access Journals (Sweden)

    Tamer Takmaz

    2011-10-01

    Full Text Available Pur po se: To evaluate the relationship between peripapillary atrophy and optic disc parameters measured by Heidelberg Retina Tomography (HRT and visual field findings in eyes with primary open-angle glaucoma. Methods: Thirty eyes of 30 patients with primary open-angle glaucoma were included in this study. In addition to routine ophthalmic examination, optic disc parameters were evaluated with HRT and visual field was evaluated with Humphrey Visual Field Analyzer. Peripapillary atrophy area was measured by drawing contour of the border of the peripapillary atrophy (Beta zone: chorioretinal atrophy area in which sclera and big choroid blood vessels were seen in HRT. The relationship between this atrophy area and both visual field findings and optic disc parameters was evaluated. Pearson’s correlation coefficient and statistical significance were calculated. Results: The mean age of the patients was 61.4±8.9 years. Measured beta zone area was 0.65±0.40 mm2. Mean deviation measured with Humphrey Visual Field Analyzer was -8.6±8.2 dB and pattern standard deviation was 6.4±4.6. Statistically significant correlation between peripapillary atrophy area and age (PC=0.495, p=0.005, mean deviation (PC=-0.554, p=0.001, cup area (PC=0.382, p=0.037, cup/disc area ratio (PC=0.562, p=0.001, linear cup/disc area ratio (PC=0.422, p=0.020 and mean retinal nerve fiber layer thickness (PC=-0.360, p=0.047 was found. There was not a significant relationship between other optic disc parameters and peripapillary atrophy area (p>0.05. Conclusion: Significant correlation was seen between peripapillary beta zone atrophy area and some important optic disk parameters in primary open-angle glaucoma patients. More meaningful information would have been obtained if sectoral investigation of the optic disc was performed. (Turk J Ophthalmol 2011; 41: 291-4

  19. Nonabelian Debye screening and the {open_quotes}tsunami{close_quotes} problem

    Energy Technology Data Exchange (ETDEWEB)

    Pisarski, R.D. [Brookhaven National Lab., Upton, NY (United States)

    1997-09-22

    The phenomenon of Debye screening is familiar from electrolytes and many other systems. Recently, it has been recognized that in nonabelian gauge theories at high temperature, even perturbatively Debye screening is much more complicated than in nonrelativistic systems. This was originally derived as {open_quotes}hard thermal loops{close_quotes}. Hard thermal loops have been derived perturbatively, by a semiclassical truncation of the Schwinger-Dyson equations, and by classical kinetic theory. In this talk I give a pedagogical derivation, following that of Kelly, Liu, Lucchesi, and Manuel. The derivation is valid not just for a thermal distribution, but (modulo certain obvious restrictions) for an arbitrary initial distribution of particles. Consider, for example, the {open_quotes}tsunami{close_quotes} problem: suppose that one starts, at time t = 0, with a spatially homogenous, infinite wall of particles, all moving with the same velocity at the speed of light.

  20. Summary report: Working group 5 on {open_quotes}Particle Beam Sources{close_quotes}

    Energy Technology Data Exchange (ETDEWEB)

    Serafini, L. [INFN-Milano and UCLA Dept. of Physics and Astronomy 405 Hilgard Ave., Los Angeles, California 90095-1547 (United States); Yeremian, A.D. [SLAC---Stanford, P.O. Box 4349, M/S 26, Stanford, California 94309 (United States)

    1997-03-01

    We report here on the activity carried in the working group on {open_quotes}Particle Beam Sources,{close_quotes} which was actually focused on electron beams and mostly covered the progress and future perspectives of laser driven RF photo-injectors. Recent experimental work on other types of electron sources were also presented: the pulsed power guns in our working group, while the plasma-based electron injectors in a joint session held with the working group on {open_quotes}Plasma-Based Accelerator Concepts.{close_quotes} Several beam dynamics issues of general interest in the field of high brightness beams production and manipulation have also been addressed by discussions and a number of communications in our working group. {copyright} {ital 1997 American Institute of Physics.}

  1. Deformed optical potential anomaly in {open_quotes}soft{close_quotes} nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Lubian, J.; Cabezas, R. [Center for Applied Studies to Nuclear Development, Havana (Cuba)

    1994-12-31

    An analysis of the low-energy neutron inelastic scattering in some {open_quotes}soft{close_quotes} nuclei is made in the region of medium atomic-weight nuclei. A combined use of the coupled channel method (CCM) and statistical Hauser-Feshbach theory is applied. As structural model of the target nucleus in the CCM calculation the Davydov-Chaban model (DCM) is used. It is observed that the lineal coefficient of the real part energy dependence of the deformed optical potential becomes unusual and increase with the {open_quotes}softness{close_quotes} of the nucleus. It is shown that in the frame of the DCM it is possible to describe adequately experimental differential, integral and total cross sections in the energy range 1-5 MeV and the structure of the low-lying collective states.

  2. Differential models for B-type open-closed topological Landau-Ginzburg theories

    CERN Document Server

    Babalic, Mirela; Lazaroiu, Calin Iuliu; Tavakol, Mehdi

    2016-01-01

    We propose a family of differential models for B-type open-closed topological Landau-Ginzburg theories defined by a pair $(X,W)$, where $X$ is any non-compact Calabi-Yau manifold and $W$ is any holomorphic complex-valued function defined on $X$ whose critical set is compact. The models are constructed at cochain level using smooth data, including the twisted Dolbeault algebra of polyvector valued forms and a twisted Dolbeault category of holomorphic factorizations of $W$. We give explicit proposals for cochain level versions of the bulk and boundary traces and for the bulk-boundary and boundary-bulk maps of the Landau-Ginzburg theory. We prove that most of the axioms of an open-closed topological field theory are satisfied on cohomology and conjecture that the remaining axioms are also satisfied.

  3. Treatment with citicoline eye drops enhances retinal function and neural conduction along the visual pathways in open angle glaucoma.

    Science.gov (United States)

    Parisi, Vincenzo; Centofanti, Marco; Ziccardi, Lucia; Tanga, Lucia; Michelessi, Manuele; Roberti, Gloria; Manni, Gianluca

    2015-08-01

    To evaluate the retinal function and the neural conduction along the visual pathways after treatment with citicoline eye drops in patients with open angle glaucoma (OAG). Fifty-six OAG patients (mean age 52.4 ± 4.72 years, IOP  0.01) PERG and VEP values in GC and GP eyes were observed. After treatment with topical citicoline, a significant (p  0.01) to baseline ones. GP eyes showed not significant changes of PERG and VEP values during the entire follow-up. Topical treatment with citicoline in OAG eyes induces an enhancement of the retinal bioelectrical responses (increase of PERG amplitude) with a consequent improvement of the bioelectrical activity of the visual cortex (shortening and increase of VEP implicit time and amplitude, respectively).

  4. Falcon: a highly flexible open-source software for closed-loop neuroscience

    Science.gov (United States)

    Ciliberti, Davide; Kloosterman, Fabian

    2017-08-01

    Objective. Closed-loop experiments provide unique insights into brain dynamics and function. To facilitate a wide range of closed-loop experiments, we created an open-source software platform that enables high-performance real-time processing of streaming experimental data. Approach. We wrote Falcon, a C++ multi-threaded software in which the user can load and execute an arbitrary processing graph. Each node of a Falcon graph is mapped to a single thread and nodes communicate with each other through thread-safe buffers. The framework allows for easy implementation of new processing nodes and data types. Falcon was tested both on a 32-core and a 4-core workstation. Streaming data was read from either a commercial acquisition system (Neuralynx) or the open-source Open Ephys hardware, while closed-loop TTL pulses were generated with a USB module for digital output. We characterized the round-trip latency of our Falcon-based closed-loop system, as well as the specific latency contribution of the software architecture, by testing processing graphs with up to 32 parallel pipelines and eight serial stages. We finally deployed Falcon in a task of real-time detection of population bursts recorded live from the hippocampus of a freely moving rat. Main results. On Neuralynx hardware, round-trip latency was well below 1 ms and stable for at least 1 h, while on Open Ephys hardware latencies were below 15 ms. The latency contribution of the software was below 0.5 ms. Round-trip and software latencies were similar on both 32- and 4-core workstations. Falcon was used successfully to detect population bursts online with ~40 ms average latency. Significance. Falcon is a novel open-source software for closed-loop neuroscience. It has sub-millisecond intrinsic latency and gives the experimenter direct control of CPU resources. We envisage Falcon to be a useful tool to the neuroscientific community for implementing a wide variety of closed-loop experiments, including those

  5. Falcon: a highly flexible open-source software for closed-loop neuroscience.

    Science.gov (United States)

    Ciliberti, Davide; Kloosterman, Fabian

    2017-05-26

    Closed-loop experiments provide unique insights into brain dynamics and function. To facilitate a wide range of closed-loop experiments, we created an open-source software platform that enables high-performance real-time processing of streaming experimental data. We wrote Falcon, a C++ multi-threaded software in which the user can load and execute an arbitrary processing graph. Each node of a Falcon graph is mapped to a single thread and nodes communicate with each other through thread-safe buffers. The framework allows for easy implementation of new processing nodes and data types. Falcon was tested both on a 32-core and a 4-core workstation. Streaming data was read from either a commercial acquisition system (Neuralynx) or the open-source Open Ephys hardware, while closed-loop TTL pulses were generated with a USB module for digital output. We characterized the round-trip latency of our Falcon-based closed-loop system, as well as the specific latency contribution of the software architecture, by testing processing graphs with up to 32 parallel pipelines and eight serial stages. We finally deployed Falcon in a task of real-time detection of population bursts recorded live from the hippocampus of a freely moving rat. On Neuralynx hardware, round-trip latency was well below 1 ms and stable for at least 1 h, while on Open Ephys hardware latencies were below 15 ms. The latency contribution of the software was below 0.5 ms. Round-trip and software latencies were similar on both 32- and 4-core workstations. Falcon was used successfully to detect population bursts online with ~40 ms average latency. Falcon is a novel open-source software for closed-loop neuroscience. It has sub-millisecond intrinsic latency and gives the experimenter direct control of CPU resources. We envisage Falcon to be a useful tool to the neuroscientific community for implementing a wide variety of closed-loop experiments, including those requiring use of complex data structures and real

  6. From "Closing Doors" to "Opening Doors": Exploring gender and subject choice in UK schools

    Science.gov (United States)

    Marks, Ann

    2015-12-01

    Two reports drawing on the National (English) Pupil Database are discussed: the It's Different for Girls and the Closing Doors reports (2012 and 2013, respectively), both of which examine the experience of girls studying physics in England. The UK government has responded to these studies by launching the "Opening Doors" project (June 2014), which will focus on a whole-school approach to addressing gender imbalance in progression to post-16 studies.

  7. Function Projective Synchronization of Fractional-Order Hyperchaotic System Based on Open-Plus-Closed-Looping

    Institute of Scientific and Technical Information of China (English)

    WANG Xing-Yuan; LIU Rong; ZHANG Na

    2011-01-01

    The purpose of this paper is to analyze the dynamic behavior of fractional-order four-order hyperchaotic Lii system, and use the Open-Plus-Closed-Looping (OPCL) coupling method to construct the system's corresponding response system, and then implement function projective synchronization (FPS) of fractional-order drive-response system with system parameters perturbation or not. Finally, the numerical simulations verify the effectiveness and robustness of this scheme.

  8. Open and Closed World Models in Kaluza-Klein-Theory with Variables G and Λ

    Science.gov (United States)

    Nashed, Gamal G. L.

    2014-11-01

    The field equation of higher dimensions theory, have been applied in the area of cosmology. The resulting differential equations are solved for open and closed. We derive a relation between the Einstein constant G( t) and the cosmological constant Λ( t) from the conservation law T μ ν ; ν =0. We give a specific form of Λ( t) to solve the non-linear differential equations. Some cosmological parameters are calculated and some relevant cosmological problems are discussed.

  9. Tensions between opening up and closing down moments in transdisciplinary water research

    Science.gov (United States)

    Krueger, Tobias; Maynard, Carly; Carr, Gemma; Bruns, Antje; Mueller, Eva; Lane, Stuart

    2016-04-01

    Research on water is carried out by many disciplines that do not really talk to each other much, despite critical interactions of multiple social and biophysical processes in shaping how much and what kind of water is where, at what time and for whom. What is more, water has meaning to more than those who are scientists. And scientists are not so removed from the things they study as one might commonly believe. All these observations call for a transdisciplinary research agenda that brings together different scientific disciplines with the knowledge that other groups in society hold and that tries to be aware of its own limitations. The transdisciplinary perspective is especially pertinent to the scientific decade 2013-2022 of the International Association of Hydrological Sciences (IAHS) on change in hydrology and society, 'Panta Rhei,' for a balanced conceptualization and study of human-water relations. Transdisciplinarity is inherently about opening up traditional modes of knowledge production; in terms of framing the research problem, the methodology and the knowledge that is considered permissible. This should open up the range of options for management intervention, too. While decisions on how to intervene will inevitably close down the issue periodically, the point here is to leave alternative routes of action open long enough, or reopen them again, so as to counter unsustainable and inequitable path-dependencies and lock-ins. However, opening up efforts are frequently in conflict with factors that work to close down knowledge production. Among those are framings, path-dependencies, vested interests, researchers' positionalities, power, and scale. In this presentation, based on Krueger et al. (2016), we will reflect on the tensions between opening up and closing down moments in transdisciplinary water research and draw important practical lessons. References Krueger, T., Maynard, C.M., Carr, G., Bruns, A., Mueller, E.N. and Lane, S.N. (forthcoming in 2016) A

  10. Comparison of body-powered voluntary opening and voluntary closing prehensor for activities of daily life

    Directory of Open Access Journals (Sweden)

    Kelsey Berning

    2014-05-01

    Full Text Available Persons with an upper-limb amputation who use a body-powered prosthesis typically control the prehensor through contralateral shoulder movement, which is transmitted through a Bowden cable. Increased cable tension either opens or closes the prehensor; when tension is released, some passive element, such as a spring, returns the prehensor to the default state (closed or open. In this study, we used the Southampton Hand Assessment Procedure to examine functional differences between these two types of prehensors in 29 nondisabled subjects (who used a body-powered bypass prosthesis and 2 persons with unilateral transradial amputations (who used a conventional body-powered device. We also administered a survey to determine whether subjects preferred one prehensor or the other for specific tasks, with a long-term goal of assessing whether a prehensor that could switch between both modes would be advantageous. We found that using the voluntary closing prehensor was 1.3 s faster (p = 0.02 than using the voluntary opening prehensor, across tasks, and that there was consensus among subjects on which types of tasks they preferred to do with each prehensor type. Twenty-five subjects wanted a device that could switch between the two modes in order to perform particular tasks.

  11. Current Concepts in the Mandibular Condyle Fracture Management Part II: Open Reduction Versus Closed Reduction

    Directory of Open Access Journals (Sweden)

    Kang-Young Choi

    2012-07-01

    Full Text Available In the treatment of mandibular condyle fracture, conservative treatment using closed reduction or surgical treatment using open reduction can be used. Management of mandibular condylar fractures remains a source of ongoing controversy in oral and maxillofacial trauma. For each type of condylar fracture,the treatment method must be chosen taking into consideration the presence of teeth, fracture height, patient'sadaptation, patient's masticatory system, disturbance of occlusal function, and deviation of the mandible. In the past, closed reduction with concomitant active physical therapy conducted after intermaxillary fixation during the recovery period had been mainly used, but in recent years, open treatment of condylar fractures with rigid internal fixation has become more common. The objective of this review was to evaluate the main variables that determine the choice of an open or closed method for treatment of condylar fractures, identifying their indications, advantages, and disadvantages, and to appraise the current evidence regarding the effectiveness of interventions that are used in the management of fractures of the mandibular condyle.

  12. Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): CLOSED AND OPEN STATE CHANNEL MODELS.

    Science.gov (United States)

    Corradi, Valentina; Vergani, Paola; Tieleman, D Peter

    2015-09-18

    The cystic fibrosis transmembrane conductance regulator (CFTR) is a member of the ATP-binding cassette (ABC) transporter superfamily. CFTR controls the flow of anions through the apical membrane of epithelia. Dysfunctional CFTR causes the common lethal genetic disease cystic fibrosis. Transitions between open and closed states of CFTR are regulated by ATP binding and hydrolysis on the cytosolic nucleotide binding domains, which are coupled with the transmembrane (TM) domains forming the pathway for anion permeation. Lack of structural data hampers a global understanding of CFTR and thus the development of "rational" approaches directly targeting defective CFTR. In this work, we explored possible conformational states of the CFTR gating cycle by means of homology modeling. As templates, we used structures of homologous ABC transporters, namely TM(287-288), ABC-B10, McjD, and Sav1866. In the light of published experimental results, structural analysis of the transmembrane cavity suggests that the TM(287-288)-based CFTR model could correspond to a commonly occupied closed state, whereas the McjD-based model could represent an open state. The models capture the important role played by Phe-337 as a filter/gating residue and provide structural information on the conformational transition from closed to open channel.

  13. Comparison of body-powered voluntary opening and voluntary closing prehensor for activities of daily life.

    Science.gov (United States)

    Berning, Kelsey; Cohick, Sarah; Johnson, Reva; Miller, Laura Ann; Sensinger, Jonathon W

    2014-01-01

    Persons with an upper-limb amputation who use a body-powered prosthesis typically control the prehensor through contralateral shoulder movement, which is transmitted through a Bowden cable. Increased cable tension either opens or closes the prehensor; when tension is released, some passive element, such as a spring, returns the prehensor to the default state (closed or open). In this study, we used the Southampton Hand Assessment Procedure to examine functional differences between these two types of prehensors in 29 nondisabled subjects (who used a body-powered bypass prosthesis) and 2 persons with unilateral transradial amputations (who used a conventional body-powered device). We also administered a survey to determine whether subjects preferred one prehensor or the other for specific tasks, with a long-term goal of assessing whether a prehensor that could switch between both modes would be advantageous. We found that using the voluntary closing prehensor was 1.3 s faster (p = 0.02) than using the voluntary opening prehensor, across tasks, and that there was consensus among subjects on which types of tasks they preferred to do with each prehensor type. Twenty-five subjects wanted a device that could switch between the two modes in order to perform particular tasks.

  14. A method for fabricating a micro-structured surface of polyimide with open and closed pores

    CERN Document Server

    Ma, Yong-Won; Ahn, Seokyoung; Shin, Bo Sung

    2016-01-01

    A new approach for fabricating open and closed porous structures based on laser processing is presented. Liquid polyimide (PI) was mixed with azodicarbonamide (ADC, ADA) which is a chemical blowing agent (CBA) and mixture was pre-cured in order to fabricate solid PI film. Porous PI was prepared by irradiating PI film mixed with azodicarbonamide. The PI film with azodicarbonamide was etched by laser ablation, and the CBA was decomposed by heat induced by the absorbed laser energy. The higher the laser beam irradiation, the more pores were fabricated due to the resulting increase in CBA decomposition from 27 mJ/cm2 to 40 mJ/cm2 per single pulse. Higher fluence at about 50 mJ/cm2 resulted in fewer and larger open pores, which were formed by the coalescence of small pores. In contrast, a closed porous structure was fabricated at a fluence of less than 1 mJ/cm2 because PI was barely etched. The proposed method can be sued to create open and closed micro porous structures selectively, and is not limited to thermose...

  15. A method for fabricating a micro-structured surface of polyimide with open and closed pores

    Science.gov (United States)

    Ma, Yong-Won; Oh, Jae Yong; Ahn, Seokyoung; Shin, Bo Sung

    2016-08-01

    A new approach for fabricating open and closed porous structures based on laser processing is presented. Liquid polyimide (PI) was mixed with azodicarbonamide which is a chemical blowing agent (CBA), and the mixture was spin-coated and pre-cured in order to fabricate solid PI films. Porous PI was prepared by irradiating PI films mixed with azodicarbonamide. The PI film with azodicarbonamide was etched by using laser ablation, and the azodicarbonamide was decomposed due to the heat induced by the absorbed laser energy. At higher laser beam irradiation, more pores were fabricated due to the resulting increase in the CBA decomposition from 27 mJ/cm2 to 40 mJ/cm2 per single pulse. A fluence of about 50 mJ/cm2 resulted in fewer and larger open pores, which were formed by the coalescence of small pores. In contrast, a closed porous structure was fabricated at a fluence of less than 1 mJ/cm2 because PI was barely etched. The proposed method can be used to create open and closed porous structures selectively and is not limited to thermosetting polymers, but is also effective with thermoplastic polymers.

  16. Open globe eye injury characteristics and prognostic factors in southern Israel: a retrospective epidemiologic review of 10 years experience.

    Science.gov (United States)

    Knyazer, Boris; Bilenko, Natalya; Levy, Jaime; Lifshitz, Tova; Belfair, Nadav; Klemperer, Itamar; Yagev, Ronit

    2013-03-01

    Open globe injury (OGI) is a common cause of unilateral visual loss in all age groups. To describe and identify clinical characteristics, prognostic factors and visual outcome in a group of patients with OGI in southern Israel. We conducted a retrospective review of all cases of OGI examined in the ophthalmology department at Soroka University Medical Center, Beer Sheva, Israel, from 1996 to 2005. A total of 118 eyes with OGI were detected and analyzed statistically. We recorded demographic data, cause of injury, initial visual acuity (VA), associated globe morbidity and injuries, Ocular Trauma Score (OTS), surgical procedures, postoperative complications, and final VA. The mean age of the study group was 36.1 years and included 84% males. The median follow-up was 13.3 months (range 6-66 months). The annual incidence of open globe injuries was 3.1 cases/100,000. In 84 cases (71%) the mechanism of open eye injury was laceration. Most of the injuries were work related (45%). Bilateral injury was observed in two patients. An intraocular foreign body was observed in 45 eyes (38%). Primary surgical repair was performed in 114 eyes. Six patients (5.1%) had complications with posttraumatic endophthalmitis and 12 patients (10.1%) underwent evisceration or enucleation. Clinical signs associated with poor visual outcomes included reduced initial VA, eyelid injury, and retinal detachment at presentation. In our study population the most important prognostic factors in open globe injury were initial VA, eyelid injury and retinal detachment.

  17. Influence of alcohol consumption on incidence and severity of open-globe eye injuries in adults.

    Science.gov (United States)

    Rüfer, Florian; Peters, Andrea; Klettner, Alexa; Treumer, Felix; Roider, Johann

    2011-12-01

    .0000). Open-globe eye injuries under alcohol intoxication are more often caused by a third party and have a worse prognosis. Open-globe injuries under alcohol intoxication occur in a different spatio-temporal setting and exhibit a more severe type of injury. Risk behavior combined with alcohol consumption therefore seems to be an independent factor for the incidence of open-globe eye injuries.

  18. Mechanism of Rh-Catalyzed Oxidative Cyclizations: Closed versus Open Shell Pathways.

    Science.gov (United States)

    Park, Yoonsu; Ahn, Seihwan; Kang, Dahye; Baik, Mu-Hyun

    2016-06-21

    A conceptual theory for analyzing and understanding oxidative addition reactions that form the cornerstone of many transition metal mediated catalytic cycles that activate C-C and C-H bonds, for example, was developed. The cleavage of the σ- or π-bond in the organic substrate can be envisioned to follow a closed or an open shell formalism, which is matched by a corresponding electronic structure at the metal center of the catalyst. Whereas the assignment of one or the other mechanistic scenario appears formal and equivalent at first sight, they should be recognized as different classes of reactions, because they lead to different reaction optimization and control strategies. The closed-shell mechanism involves heterolytic bond cleavages, which give rise to highly localized charges to form at the transition state. In the open-shell pathway, bonds are broken homolytically avoiding localized charges to accumulate on molecular fragments at the transition states. As a result, functional groups with inductive effects may exert a substantial influence on the energies of the intermediate and transition states, whereas no such effect is expected if the mechanism proceeds through the open-shell mechanism. If these functional groups are placed in a way that opens an electronic communication pathway to the molecular sites where charges accumulate, for example, using hyperconjugation, electron donating groups may stabilize a positive charge at that site. An instructive example is discussed, where this stereoelectronic effect allowed for rendering the oxidative addition diastereoselective. No such control is possible, however, when the open-shell reaction pathway is followed, because the inductive effects of functional groups have little to no effect on the stabilities of radical-like substrate states that are encountered when the bonds are broken in a homolytic fashion. Whether the closed-shell or open-shell mechanism for oxidative addition is followed is determined by the

  19. Sensitive periods differentiate processing of open- and closed-class words: an ERP study of bilinguals.

    Science.gov (United States)

    Weber-Fox, C; Neville, H J

    2001-12-01

    The goal of this study was to test the hypothesis that neural processes for language are heterogeneous in their adaptations to maturation and experience. This study examined whether the neural processes for open- and closed-class words are differentially affected by delays in second-language immersion. In English, open-class words primarily convey referential meaning, whereas closed-class words are primarily related to grammatical information in sentence processing. Previous studies indicate that event-related brain potentials (ERPs) elicited by these word classes display nonidentical distributions and latencies, show different developmental time courses, and are differentially affected by early language experience in Deaf individuals. In this study, ERPs were recorded from 10 monolingual English speakers and 53 Chinese-English bilingual speakers who were grouped according to their age of immersion in English: 1-3, 4-6, 7-10, 11-13, and >15 years of age. Closed-class words elicited an N280 that was largest over left anterior electrode sites for all groups. However, the peak latency was later (>35 ms) in bilingual speakers immersed in English after 7 years of age. In contrast, the latencies and distributions of the N350 elicited by open-class words were similar in all groups. In addition, the N400, elicited by semantic anomalies (open-class words that violated semantic expectation), displayed increased peak latencies for only the later-learning bilingual speakers (>11 years). These results are consistent with the hypothesis that language subprocesses are differentially sensitive to the timing of second-language experience.

  20. How the Story Unfolds: Exploring Ways Faculty Develop Open-Ended and Closed-Ended Case Designs

    Science.gov (United States)

    Nesbitt, Leslie M.; Cliff, William H.

    2008-01-01

    Open-ended or closed-ended case study design schemes offer different educational advantages. Anatomy and physiology faculty members who participated in a conference workshop were given an identical case about blood doping and asked to build either an open-ended study or a closed-ended study. The workshop participants created a rich array of case…

  1. Functional motions of Candida antarctica lipase B: a survey through open-close conformations.

    Directory of Open Access Journals (Sweden)

    Mohamad Reza Ganjalikhany

    Full Text Available Candida antarctica lipase B (CALB belongs to psychrophilic lipases which hydrolyze carboxyl ester bonds at low temperatures. There have been some features reported about cold-activity of the enzyme through experimental methods, whereas there is no detailed information on its mechanism of action at molecular level. Herein, a comparative molecular dynamics simulation and essential dynamics analysis have been carried out at three temperatures (5, 35 and 50 °C to trace the dominant factors in the psychrophilic properties of CALB under cold condition. The results clearly describe the effect of temperature on CALB with meaningful differences in the flexibility of the lid region (α5 helix, covering residues 141-147. Open- closed conformations have been obtained from different sets of long-term simulations (60 ns at 5 °C gave two reproducible distinct forms of CALB. The starting open conformation became closed immediately at 35 and 50 °C during 60 ns of simulation, while a sequential open-closed form was observed at 5 °C. These structural alterations were resulted from α5 helical movements, where the closed conformation of active site cleft was formed by displacement of both helix and its side chains. Analysis of normal mode showed concerted motions that are involved in the movement of both α5 and α10 helices. It is suggested that the functional motions needed for lypolytic activity of CALB is constructed from short-range movement of α5, accompanied by long-range movement of the domains connected to the lid region.

  2. Cross-sectional study of the association between a deepening of the upper eyelid sulcus-like appearance and wide-open eyes.

    Directory of Open Access Journals (Sweden)

    Shunsuke Nakakura

    Full Text Available BACKGROUND: Deepening of the upper eyelid sulcus (DUES is a common complication of prostaglandin F2α analog treatment, which causes cosmetic problems. However, identifying this condition using photographs is difficult due to such problems as the camera flash effects, blepharoptosis or wide-open eyes. PURPOSE: We investigated the association between a DUES-like appearance and wide-open eyes regarding the presence of wide-open eyes as a cause for overestimating the incidence of DUES. SUBJECTS AND METHODS: One eye and the forehead in 100 subjects (31 younger subjects, 30 older subjects and 39 patients with blepharoptosis were evaluated in the present study. Digital photographs of the subjects with natural open and wide-open eyes were taken with a flash. Five signs (a puffy eyelid, the presence/absence of the upper eyelid sulcus (UES, wrinkles on the forehead with natural open eyes and an increase in the number of wrinkles on the forehead and a DUES-like appearance with wide-open eyes were judged to be negative or positive by three independent observers. Univariate and multivariate logistic regression analyses were performed to determine the independent predictor(s of a DUES-like appearance with wide-open eyes. RESULTS: Fourteen subjects (four young, three old and seven subjects with blepharoptosis were judged to have a DUES-like appearance with wide-open eyes (14%. The only predictive factor was the presence of UES in the patients with natural open eyes (odds ratio = 17.244, 95% confidence interval: 3.447-86.270, P<0.001. Among the 12 UES-positive subjects, six (50% exhibited a DUES-like appearance with wide-open eyes. CONCLUSIONS: The presence of wide-open eyes can thus cause a DUES-like appearance. Blepharoptosis itself is not a predictive factor; however, care should be taken not to overestimate the incidence of DUES, especially in patients with UES with natural open eyes, as a DUES-like appearance can be caused by wide-open eyes, even in

  3. Structural comparison between the open and closed forms of citrate synthase from Thermus thermophilus HB8.

    Science.gov (United States)

    Kanamori, Eiji; Kawaguchi, Shin-Ichi; Kuramitsu, Seiki; Kouyama, Tsutomu; Murakami, Midori

    2015-01-01

    The crystal structures of citrate synthase from the thermophilic eubacteria Thermus thermophilus HB8 (TtCS) were determined for an open form at 1.5 Å resolution and for closed form at 2.3 Å resolution, respectively. In the absence of ligands TtCS in the open form was crystalized into a tetragonal form with a single subunit in the asymmetric unit. TtCS was also co-crystallized with citrate and coenzyme-A to form an orthorhombic crystal with two homodimers in the asymmetric unit. Citrate and CoA are found in the active site situated between the large domain and the small domain in all subunit whereas the complex shows two distinct closed conformations, the fully closed form and partially closed form. Structural comparisons are performed to describe conformational changes associated with binding of products of TtCS. Upon binding of citrate, basic residues in the active site move toward citrate and make a hydrogen bond network in the active site, inducing a large-scale rotation of the small domain relative to the large domain. CoA is sandwiched between the small and large domains and then the cysteamine tail is inserted into the active site with a cooperative rotation around mainchain dihedrals in the hinge region connecting helices M and N. According to this rotation these helices are extended to close the active site completely. The considerable flexibility and structural rearrangements in the hinge region are crucial for an ordered bibi reaction in catalysis for microbial CSs.

  4. A multicenter, open-label, 52-week study of 2% rebamipide (OPC-12759) ophthalmic suspension in patients with dry eye.

    Science.gov (United States)

    Kinoshita, Shigeru; Awamura, Saki; Nakamichi, Norihiro; Suzuki, Hiroyuki; Oshiden, Kazuhide; Yokoi, Norihiko

    2014-03-01

    To investigate the efficacy and safety of 2% rebamipide ophthalmic suspension administered 4 times daily for 52 weeks in patients with dry eye. Multicenter (17 sites), open-label, single-arm study. A total of 154 patients with dry eye were enrolled in this study. After a 2-week screening period, patients received 2% rebamipide, instilled as 1 drop in each eye, 4 times daily for 52 weeks. The signs and symptoms measures were assessed at baseline, at weeks 2 and 4, and at every 4 weeks thereafter. The objective signs were fluorescein corneal staining score, lissamine green conjunctival staining score, and tear film break-up time, while subjective symptoms were dry eye-related ocular symptoms (foreign body sensation, dryness, photophobia, eye pain, and blurred vision). The safety variable was the occurrence of adverse events. For all objective signs and subjective symptoms, the scores significantly improved at week 2 compared with baseline (P rebamipide is effective in improving both the objective signs and subjective symptoms of dry eye patients for at least 52 weeks. In addition, 2% rebamipide treatment was generally well tolerated. Copyright © 2014. Published by Elsevier Inc.

  5. Switchable Opening and Closing of a Liquid Marble via Ultrasonic Levitation.

    Science.gov (United States)

    Zang, Duyang; Li, Jun; Chen, Zhen; Zhai, Zhicong; Geng, Xingguo; Binks, Bernard P

    2015-10-27

    Liquid marbles have promising applications in the field of microreactors, where the opening and closing of their surfaces plays a central role. We have levitated liquid water marbles using an acoustic levitator and, thereby, achieved the manipulation of the particle shell in a controlled manner. Upon increasing the sound intensity, the stable levitated liquid marble changes from a quasi-sphere to a flattened ellipsoid. Interestingly, a cavity on the particle shell can be produced on the polar areas, which can be completely healed when decreasing the sound intensity, allowing it to serve as a microreactor. The integral of the acoustic radiation pressure on the part of the particle surface protruding into air is responsible for particle migration from the center of the liquid marble to the edge. Our results demonstrate that the opening and closing of the liquid marble particle shell can be conveniently achieved via acoustic levitation, opening up a new possibility to manipulate liquid marbles coated with non-ferromagnetic particles.

  6. Open and Closed Endotracheal Suctioning and Arterial Blood Gas Values: A Single-Blind Crossover Randomized Clinical Trial

    Directory of Open Access Journals (Sweden)

    Azam Faraji

    2015-01-01

    Full Text Available Aim. This study was aimed at comparing the effects of the open and closed suctioning techniques on the arterial blood gas values in patients undergoing open-heart surgery. Methods. In a clinical trial, we recruited 42 patients after open-heart surgery in an educational hospital. Each patient randomly underwent both open and closed suctioning. ABGs, PaO2, SaO2, PaCO2, were analyzed before and one, five, and fifteen minutes after each suctioning episode. Results. At first the pressure of oxygen in arterial blood increased; however, this increase in the open technique was greater than that of the closed system (P<0.001. The pressure of oxygen decreased five and fifteen minutes after both suctioning techniques (P<0.05. The trends of carbon dioxide variations after the open and closed techniques were upward and downward, respectively. Moreover, the decrease in the level of oxygen saturation five and fifteen minutes after the open suctioning was greater than that of the closed suctioning technique (P<0.05.  Conclusion. Arterial blood gas disturbances in the closed suctioning technique were less than those of the open technique. Therefore, to eliminate the unwanted effects of endotracheal suctioning on the arterial blood gases, the closed suctioning technique is recommended.

  7. Borane catalysed ring opening and closing cascades of furans leading to silicon functionalized synthetic intermediates

    Science.gov (United States)

    Hazra, Chinmoy K.; Gandhamsetty, Narasimhulu; Park, Sehoon; Chang, Sukbok

    2016-11-01

    The conversion of renewable biomass resources to synthetically valuable chemicals is highly desirable, but remains a formidable challenge in regards to the substrate scope and reaction conditions. Here we present the development of tris(pentafluorophenyl)borane-catalysed conversion of furans via ring-opening and closing cascade processes to afford silicon-functionalized synthetic chemicals under transition metal-free conditions. The furan ring-opening with hydrosilanes is highly efficient (TON up to 2,000) and atom-economical without forming any byproduct to give rise to α-silyloxy-(Z)-alkenyl silanes. Additional equivalents of silane smoothly induce a subsequent B(C6F5)3-catalysed cyclization of initially formed olefinic silane compounds to produce anti-(2-alkyl)cyclopropyl silanes, another versatile synthon being potentially applicable in the synthesis of natural products and pharmacophores.

  8. Open- and closed-formula laboratory animal diets and their importance to research.

    Science.gov (United States)

    Barnard, Dennis E; Lewis, Sherry M; Teter, Beverly B; Thigpen, Julius E

    2009-11-01

    Almost 40 y ago the scientific community was taking actions to control environmental factors that contribute to variation in the responses of laboratory animals to scientific manipulation. Laboratory animal diet was recognized as an important variable. During the 1970s, the American Institute of Nutrition, National Academy of Science, Institute of Laboratory Animal Resources, and Laboratory Animals Centre Diets Advisory Committee supported the use of 'standard reference diets' in biomedical research as a means to improve the ability to replicate research. As a result the AIN76 purified diet was formulated. During this same time, the laboratory animal nutritionist at the NIH was formulating open-formula, natural-ingredient diets to meet the need for standardized laboratory animal diets. Since the development of open-formula diets, fixed-formula and constant-nutrient-concentration closed-formula laboratory animal natural ingredient diets have been introduced to help reduce the potential variation diet can cause in research.

  9. Note on Mediation of Supersymmetry Breaking from Closed to Open Strings

    CERN Document Server

    Antoniadis, Ignatios; Antoniadis, Ignatios; Taylor, Tomasz R.

    2005-01-01

    We discuss the mediation of supersymmetry breaking from closed to open strings, extending and improving previous analysis of the authors in Nucl. Phys. B 695 (2004) 103 [hep-th/0403293]. In the general case, we find the absence of anomaly mediation around any perturbative string vacuum. When supersymmetry is broken by Scherk-Schwarz boundary conditions along a compactification interval perpendicular to a stack of D-branes, the gaugino acquires a mass at two loops that behaves as $m_{1/2}\\sim g^4 m_{3/2}^3$ in string units, where $m_{3/2}$ is the gravitino mass and $g$ is the gauge coupling.

  10. Inverse synchronization of coupled fractional-order systems through open-plus-closed-loop control

    Indian Academy of Sciences (India)

    Junwei Wang; Li Zeng; Qinghua Ma

    2011-03-01

    In this paper, the inverse synchronization problem of fractional-order dynamical systems is investigated. A general explicit coupling via an open-plus-closed-loop control for inverse synchronization of two arbitrary unidirectionally or bidirectionally coupled fractional-order systems is proposed. The inverse synchronization is proved analytically based on the stability theorem of the fractional differential equations. A key feature of this proposed scheme is that it can be applied not only to nonchaotic but also to chaotic fractional-order systems whenever they exhibit regular or irregular oscillations. Feasibility of the proposed inverse synchronization scheme is illustrated through numerical simulations.

  11. Starting position of movement and perception of angle of trunk flexion while standing with eyes closed.

    Science.gov (United States)

    Fujiwara, K; Miyaguchi, A; Toyama, H; Kunita, K; Asai, H

    1999-08-01

    The present study attempted to investigate the effect of position on the perception of angle of trunk flexion while standing. For this purpose, the range effect was factored out by setting the constant target angle at 10 degrees, with varied starting positions of trunk flexion. We found that subjects underestimated angle of trunk flexion when the starting position was close to a quiet standing posture, overestimated when close to maximum trunk flexion, and correctly perceived it when at the middle position. Less perceptual distortion was observed at the positions close to maximum trunk flexion in the present study than in our previous one, in which various target angles of trunk flexion were reproduced from a quiet standing posture. The reduced distortion in the present study was believed to have resulted from factoring out the range effect. The flexion angle of the hip joint changed in tandem with that of the trunk, while very little movement was observed in the ankle, knee, and neck joints. Judging from the changing pattern of hip-joint angle, the muscle activity of the erector spinae and biceps femoris increased gradually to 90 degrees trunk flexion. In contrast, the actual increment of muscle activity reached zero or a minimum value at the middle angles as the angle of trunk flexion increased. It was assumed that the abrupt change in kinesthetic information associated with muscle activity exerted a great influence on the perception of trunk flexion.

  12. Association of Myopic Deformation of Optic Disc with Visual Field Progression in Paired Eyes with Open-Angle Glaucoma

    Science.gov (United States)

    Hangai, Masanori; Ishikawa, Makoto; Yoshitomi, Takeshi

    2017-01-01

    Purpose The influence of myopia on glaucoma progression remains unknown, possibly because of the multifactorial nature of glaucoma and difficulty in assessing a solo contribution of myopia. The purpose of this study is to investigate the association of myopia with visual field (VF) progression in glaucoma using a paired-eye design to minimize the influence of confounding systemic factors that are diverse among individuals. Methods This retrospective study evaluated 144 eyes of 72 subjects with open-angle glaucoma, with similar intra-ocular pressure between paired eyes, spherical equivalent (SE) ≤ -2 diopter (D), and axial length ≥ 24 mm. Paired eyes with faster and slower VF progression were grouped separately, according to the global VF progression rate assessed by automated pointwise linear regression analysis. The SE, axial length, tilt ratio and torsion angle of optic discs, Bruch’s membrane (BM) opening area, and gamma zone parapapillary atrophy (PPA) width were compared between the two groups. Factors associated with faster VF progression were determined by logistic regression analysis. Results The mean follow-up duration was 8.9 ± 4.4 years. The mean value of SE and axial length were -6.31 ± 1.88 D and 26.05 ± 1.12 mm, respectively. The mean global visual field progression rate was -0.32 ± 0.38 dB/y. Tilt ratio, BM opening area, and gamma zone PPA width were significantly greater in the eyes with faster VF progression than those with slower progression. In multivariate analysis, these factors were significantly associated with faster VF progression (all P < 0.05), while SE and axial length were not associated with it. Conclusion In myopic glaucoma subjects, tilt of the optic disc and temporal shifting and enlargement of the BM opening were associated with faster rate of VF progression between paired eyes. This suggests that myopia influences VF progression in glaucomatous eyes via optic disc deformations rather than via refractive error itself

  13. 闭眼和睡眠对人角膜地形和散光的影响研究%lmpact study of closing eyes and sleep on corneal topography and corneal astigmatism

    Institute of Scientific and Technical Information of China (English)

    袁韬; 陆静

    2015-01-01

    目的:观察不同时间长度闭眼和睡眠后角膜地形图、角膜散光等的变化,研究闭眼以及睡眠造成的生理性缺氧对人眼角膜形态的影响。  方法:选取年龄22~33(26.19±3.95)岁的自愿者,排除屈光介质疾病及眼部其他疾病、无角膜接触镜配戴史等,共16例32眼,其中男10眼,女22眼。主要参数采用了Zeiss角膜地形图仪获取角膜模拟K值、角膜散光值、角膜表面不规则指数( CIM )和形状因子( SF ),测量时间点分别为:日间闭眼前、闭眼后10,20,30,60,120 min;夜间临睡前、超过6h 的睡眠结束后,开眼立即检测、开眼后10,20,60,120 min。  结果:闭眼过程中,人角膜地形图、角膜散光、CIM、SF等的变化差异无统计学意义。在超过6h的睡眠结束,开眼后过程中,人角膜地形图、角膜散光、CIM、SF等的变化差异无统计学意义。  结论:闭眼和睡眠没有构成对角膜实质性损伤,所以角膜地形和散光基本不变。%•AlM: To observe the changes of corneal topography and astigmatism et al with various duration of closing eyes and sleep;and study the impact of closing eye and sleep causing physiological hypoxia on corneal topography. • METHODS: Sixteen volunteers were selected ( 32 eyes), 22-33 (26. 19 ± 3. 95) years old, without refractive errors and other eye diseases, as well as never wearing corneal contact lens, including 10 male eyes and 22 female eyes. The main parameters received corneal simulation K value, corneal astigmatism, corneal irregular measure ( ClM ) and the shape factor ( SF ) by Zeiss corneal topographer. They were measured before and after closed eyes 10, 20, 30, 60, 120min; before sleep and after over 6h sleep, they were detected immediately as soon as they opened eyes after 10, 20, 60, 120min. • RESULTS: During closing eyes, there were no statistical significance on the changes of corneal topography, corneal astigmatism, and SF. After opening

  14. Evalutation of efficiency of dynamic laser magnetic stimulation of eye drainage system of patients with open angle glaucomatosis

    Directory of Open Access Journals (Sweden)

    Sidelnikova V.S.

    2014-06-01

    Full Text Available The purpose of the study is to develop a comprehensive treatment aimed at improving uveoscleral outflow in the application of dynamic laser magnetic stimulation of the drainage system of the eye and evaluation of its effectiveness in treating patients with primary open-angle glaucoma (POAG. Material. 106 patients diagnosed POAG I, II, III stages were examined. Group 1 consisted of 62 patients treated with medical therapy and dynamic laser magnetic stimulation of the drainage system of the eye using the "AMO-ATOS-ICL", produced by JSC "TRIMA", Saratov. Group 2 consisted of 64 patients who received only medical therapy. Comprehensive survey including standard eye examination, static perimetry, visual evoked potentials study, the study of intraocular blood flow was conducted to all patients. Analysis of the results of the complex therapeutic effects showed that as the result of treatment 73% of patients had a decrease of intraocular pressure and the ease factor outflow increase. 52% of patients had a decrease in the number and area of relative. 63% of patients had activation of intraocular blood flow. These indices remained stable for three months. Conclusion. The treatment with the technique of dynamic laser magnetic stimulation of the drainage system of the eye of patients with primary open-angle glaucoma leads to lower intraocular pressure, and to the improvement of dopple-rographic and perimetric indications.

  15. Sports training enhances visuo-spatial cognition regardless of open-closed typology

    Directory of Open Access Journals (Sweden)

    Ting-Yu Chueh

    2017-05-01

    Full Text Available The aim of this study was to investigate the effects of open and closed sport participation on visuo-spatial attention and memory performance among young adults. Forty-eight young adults—16 open-skill athletes, 16 closed-skill athletes, and 16 non-athletes controls—were recruited for the study. Both behavioral performance and event-related potential (ERP measurement were assessed when participants performed non-delayed and delayed match-to-sample task that tested visuo-spatial attention and memory processing. Results demonstrated that regardless of training typology, the athlete groups exhibited shorter reaction times in both the visuo-spatial attention and memory conditions than the control group with no existence of speed-accuracy trade-off. Similarly, a larger P3 amplitudes were observed in both athlete groups than in the control group for the visuo-spatial memory condition. These findings suggest that sports training, regardless of typology, are associated with superior visuo-spatial attention and memory performance, and more efficient neural resource allocation in memory processing.

  16. Conductance of closed and open long Aharonov-Bohm-Kondo rings

    Science.gov (United States)

    Shi, Zheng; Komijani, Yashar

    2017-02-01

    We calculate the finite temperature linear dc conductance of a generic single-impurity Anderson model containing an arbitrary number of Fermi liquid leads, and apply the formalism to closed and open long Aharonov-Bohm-Kondo (ABK) rings. We show that, as with the short ABK ring, there is a contribution to the conductance from the connected four-point Green's function of the conduction electrons. At sufficiently low temperatures this contribution can be eliminated, and the conductance can be expressed as a linear function of the T matrix of the screening channel. For closed rings we show that at temperatures high compared to the Kondo temperature, the conductance behaves differently for temperatures above and below vF/L , where vF is the Fermi velocity and L is the circumference of the ring. For open rings, when the ring arms have both a small transmission and a small reflection, we show from the microscopic model that the ring behaves like a two-path interferometer, and that the Kondo temperature is unaffected by details of the ring. Our findings confirm that ABK rings are potentially useful in the detection of the size of the Kondo screening cloud, the π /2 scattering phase shift from the Kondo singlet, and the suppression of Aharonov-Bohm oscillations due to inelastic scattering.

  17. Fluoride-Triggered Ring-Opening of Photochromic Diarylpyrans into Merocyanine Dyes: Naked-Eye Sensing in Subppm Levels.

    Science.gov (United States)

    Mukhopadhyay, Arindam; Maka, Vijay Kumar; Moorthy, Jarugu Narasimha

    2016-09-02

    The fluoride-mediated desilylation reaction has been exploited, for the first time, to trigger ring-opening of photochromic diarylbenzo-/naphthopyrans into highly colored anionic merocyanine dyes with high molar absorptivities to permit naked-eye sensing. The absorption spectral shifts, i.e., differences in the absorption maxima of colorless and colored forms, observed for a rationally designed set of silyloxy-substituted diarylpyrans subsequent to fluoride-induced ring opening are remarkably high (330-480 nm), and are unknown for any colorimetric probe. In particular, the disilyloxy-substituted diphenylnaphthopyran and its analog, in which the diphenyl groups are fused in the form of fluorene, allows "naked-eye" detection of fluoride in subppm levels (photochromic benzo-/naphthopyrans is heretofore unprecedented.

  18. Collecting a better water-quality sample: Reducing vertical stratification bias in open and closed channels

    Science.gov (United States)

    Selbig, William R.

    2017-01-01

    Collection of water-quality samples that accurately characterize average particle concentrations and distributions in channels can be complicated by large sources of variability. The U.S. Geological Survey (USGS) developed a fully automated Depth-Integrated Sample Arm (DISA) as a way to reduce bias and improve accuracy in water-quality concentration data. The DISA was designed to integrate with existing autosampler configurations commonly used for the collection of water-quality samples in vertical profile thereby providing a better representation of average suspended sediment and sediment-associated pollutant concentrations and distributions than traditional fixed-point samplers. In controlled laboratory experiments, known concentrations of suspended sediment ranging from 596 to 1,189 mg/L were injected into a 3 foot diameter closed channel (circular pipe) with regulated flows ranging from 1.4 to 27.8 ft3 /s. Median suspended sediment concentrations in water-quality samples collected using the DISA were within 7 percent of the known, injected value compared to 96 percent for traditional fixed-point samplers. Field evaluation of this technology in open channel fluvial systems showed median differences between paired DISA and fixed-point samples to be within 3 percent. The range of particle size measured in the open channel was generally that of clay and silt. Differences between the concentration and distribution measured between the two sampler configurations could potentially be much larger in open channels that transport larger particles, such as sand.

  19. Open or close the gate - stomata action under the control of phytohormones in drought stress conditions.

    Science.gov (United States)

    Daszkowska-Golec, Agata; Szarejko, Iwona

    2013-01-01

    Two highly specialized cells, the guard cells that surround the stomatal pore, are able to integrate environmental and endogenous signals in order to control the stomatal aperture and thereby the gas exchange. The uptake of CO2 is associated with a loss of water by leaves. Control of the size of the stomatal aperture optimizes the efficiency of water use through dynamic changes in the turgor of the guard cells. The opening and closing of stomata is regulated by the integration of environmental signals and endogenous hormonal stimuli. The various different factors to which the guard cells respond translates into the complexity of the network of signaling pathways that control stomatal movements. The perception of an abiotic stress triggers the activation of signal transduction cascades that interact with or are activated by phytohormones. Among these, abscisic acid (ABA), is the best-known stress hormone that closes the stomata, although other phytohormones, such as jasmonic acid, brassinosteroids, cytokinins, or ethylene are also involved in the stomatal response to stresses. As a part of the drought response, ABA may interact with jasmonic acid and nitric oxide in order to stimulate stomatal closure. In addition, the regulation of gene expression in response to ABA involves genes that are related to ethylene, cytokinins, and auxin signaling. In this paper, recent findings on phytohormone crosstalk, changes in signaling pathways including the expression of specific genes and their impact on modulating stress response through the closing or opening of stomata, together with the highlights of gaps that need to be elucidated in the signaling network of stomatal regulation, are reviewed.

  20. Investigating the Contextual Interference Effect Using Combination Sports Skills in Open and Closed Skill Environments

    Directory of Open Access Journals (Sweden)

    Jadeera P.G. Cheong, Brendan Lay, Rizal Razman

    2016-03-01

    Full Text Available This study attempted to present conditions that were closer to the real-world setting of team sports. The primary purpose was to examine the effects of blocked, random and game-based training practice schedules on the learning of the field hockey trap, close dribble and push pass that were practiced in combination. The secondary purpose was to investigate the effects of predictability of the environment on the learning of field hockey sport skills according to different practice schedules. A game-based training protocol represented a form of random practice in an unstable environment and was compared against a blocked and a traditional random practice schedule. In general, all groups improved dribble and push accuracy performance during the acquisition phase when assessed in a closed environment. In the retention phase, there were no differences between the three groups. When assessed in an open skills environment, all groups improved their percentage of successful executions for trapping and passing execution, and improved total number of attempts and total number of successful executions for both dribbling and shooting execution. Between-group differences were detected for dribbling execution with the game-based group scoring a higher number of dribbling successes. The CI effect did not emerge when practicing and assessing multiple sport skills in a closed skill environment, even when the skills were practiced in combination. However, when skill assessment was conducted in a real-world situation, there appeared to be some support for the CI effect.

  1. Closed-loop, multichannel experimentation using the open-source NeuroRighter electrophysiology platform

    Directory of Open Access Journals (Sweden)

    Jonathan Paul Newman

    2013-01-01

    Full Text Available Single neuron feedback control techniques, such as voltage clamp and dynamic clamp, have enabled numerous advances in our understanding of ion channels, electrochemical signaling, and neural dynamics. Although commercially available multichannel recording and stimulation systems are commonly used for studying neural processing at the network level, they provide little native support for real-time feedback. We developed the open-source NeuroRighter multichannel electrophysiology hardware and software platform for closed-loop multichannel control with a focus on accessibility and low cost. NeuroRighter allows 64 channels of stimulation and recording for around US $10,000, along with the ability to integrate with other software and hardware. Here, we present substantial enhancements to the NeuroRighter platform, including a redesigned desktop application, a new stimulation subsystem allowing arbitrary stimulation patterns, low-latency data servers for accessing data streams, and a new application programming interface (API for creating closed-loop protocols that can be inserted into NeuroRighter as plugin programs. This greatly simplifies the design of sophisticated real-time experiments without sacrificing the power and speed of a compiled programming language. Here we present a detailed description of NeuroRighter as a stand alone application, its plugin API, and an extensive set of case studies that highlight the system's abilities for conducting closed-loop, multichannel interfacing experiments.

  2. Trabecular-Iris Circumference Volume in Open Angle Eyes Using Swept-Source Fourier Domain Anterior Segment Optical Coherence Tomography

    Directory of Open Access Journals (Sweden)

    Mohammed Rigi

    2014-01-01

    Full Text Available Purpose. To introduce a new anterior segment optical coherence tomography parameter, trabecular-iris circumference volume (TICV, which measures the integrated volume of the peripheral angle, and establish a reference range in normal, open angle eyes. Methods. One eye of each participant with open angles and a normal anterior segment was imaged using 3D mode by the CASIA SS-1000 (Tomey, Nagoya, Japan. Trabecular-iris space area (TISA and TICV at 500 and 750 µm were calculated. Analysis of covariance was performed to examine the effect of age and its interaction with spherical equivalent. Results. The study included 100 participants with a mean age of 50 (±15 years (range 20–79. TICV showed a normal distribution with a mean (±SD value of 4.75 µL (±2.30 for TICV500 and a mean (±SD value of 8.90 µL (±3.88 for TICV750. Overall, TICV showed an age-related reduction (P=0.035. In addition, angle volume increased with increased myopia for all age groups, except for those older than 65 years. Conclusions. This study introduces a new parameter to measure peripheral angle volume, TICV, with age-adjusted normal ranges for open angle eyes. Further investigation is warranted to determine the clinical utility of this new parameter.

  3. Fisheries Closed Areas Strengthen Scallop Larval Settlement and Connectivity Among Closed Areas and Across International Open Fishing Grounds: A Model Study

    Science.gov (United States)

    Davies, Kimberley T. A.; Gentleman, W. C.; DiBacco, C.; Johnson, C. L.

    2015-09-01

    This study examined whether a measured increase in average body size of adult sea scallops inside three fishery closed areas on Georges Bank (GB), United States (US), was sufficient to increase larval supply to closed areas and open fishing areas in both US and Canadian areas of the Bank. The effects of adult scallop density-at-size and fecundity-at-size on egg production were compared among open and closed fishery areas, countries, and time periods before and after the closed areas were established. Estimated egg production was then used to define spawning conditions in a coupled biological-physical larval tracking model that simulated larval development, mortality, and dispersal. Results showed that order of magnitude increases in larval settlement after closure were facilitated by increases in size-dependant egg production inside and dispersal from Closed Areas I and II, but not Nantucket Lightship Closed Area. The distributions of both egg production and larval settlement became more uniform across the Bank, causing the relative contribution of Canadian larvae to US scallop aggregations to decrease after establishment of Closed Areas I and II. Decreases in small and medium-sized scallop density in Canada and decreases in large scallops over the US-Southern Flank after closure caused local declines in egg production but were not sufficient to negatively affect larval settlement at the regional scale. Our model suggests that the establishment of fishery closed areas on GB considerably strengthened larval supply and settlement within and among several adult scallop aggregations.

  4. A chloride capturing system via proton-induced structure transformation between opened- and closed-forms of dodecavanadates.

    Science.gov (United States)

    Inoue, Yoshitaka; Kikukawa, Yuji; Kuwajima, Sho; Hayashi, Yoshihito

    2016-05-01

    Chloride-incorporated dodecavanadates show two distinct structures of the monoprotonated-form [HV12O32(Cl)](4-) (closed-V12) with a spherical closed-structure and the opened-form [V12O32(Cl)](5-) (opened-V12). The reaction of closed-V12 with a stoichiometric amount of ethylenediamine drives the structure transformation reaction to opened-V12, quantitatively. From time dependent observations of (51)V NMR, a tube-type intermediate [V12O32(Cl)](5-) (tube-V12) was observed in the transformation process. Isolation of the intermediate was achieved by the deprotonation reaction of closed-V12 with diethylamine, and the structure transformation was confirmed by using the isolated intermediate. The reverse transformation from opened-V12 to closed-V12 was also achieved by addition of trifluoroacetic acid. The geometrical difference between closed-V12 and opened-V12 is reflected in the reactivity difference to the external reagents, and this was demonstrated by examining the chloride removal reaction by using a silver cation. The incorporated chloride was preserved in the closed-V12 cage even in the presence of a silver cation. In contrast, the chloride in opened-V12 was removed as AgCl by the silver cation. In addition, by the reaction of chloride-free opened-V12 with a quantitative amount of {Et4N}Cl retrieved opened-V12, showing the capability of opened-V12 to recapture a guest chloride in the cavity. This transformation between two isomeric dodecavanadate structures is regarded as the movement of a molecular mitt to catch a ball and secure it.

  5. Closed versus open endotracheal suctioning in preterm infants: effects on cerebral oxygenation and blood volume.

    Science.gov (United States)

    Mosca, F A; Colnaghi, M; Lattanzio, M; Bray, M; Pugliese, S; Fumagalli, M

    1997-01-01

    The aim of our study was to compare, using near-infrared spectroscopy (NIRS), the effects on cerebral intracellular oxygenation and cerebral blood volume (CBV) of closed endotracheal suctioning (CS), which permits continuous ventilation of the patient, with open endotracheal suctioning (OS), which requires disconnection from the ventilator. Eleven preterm infants were studied. Each patient underwent one CS, followed, after 60 min, by one OS, or vice versa, three times during the same day. Modifications in CBV and oxidized cytochrome oxidase (CytO2) were continuously detected by NIRS; arterial oxygen saturation (SaO2) heart rate (HR), transcutaneous carbon dioxide tension and mean arterial blood pressure were simultaneously recorded. Significant reductions in HR and SaO2 were observed following OS; the magnitude and duration of these negative effects of suctioning were significantly reduced with CS. In addition, the decrease in CBV was more pronounced than following CS. No changes in CytO2 concentration were seen.

  6. Supported Catalysts Useful in Ring-Closing Metathesis, Cross Metathesis, and Ring-Opening Metathesis Polymerization

    Directory of Open Access Journals (Sweden)

    Jakkrit Suriboot

    2016-04-01

    Full Text Available Ruthenium and molybdenum catalysts are widely used in synthesis of both small molecules and macromolecules. While major developments have led to new increasingly active catalysts that have high functional group compatibility and stereoselectivity, catalyst/product separation, catalyst recycling, and/or catalyst residue/product separation remain an issue in some applications of these catalysts. This review highlights some of the history of efforts to address these problems, first discussing the problem in the context of reactions like ring-closing metathesis and cross metathesis catalysis used in the synthesis of low molecular weight compounds. It then discusses in more detail progress in dealing with these issues in ring opening metathesis polymerization chemistry. Such approaches depend on a biphasic solid/liquid or liquid separation and can use either always biphasic or sometimes biphasic systems and approaches to this problem using insoluble inorganic supports, insoluble crosslinked polymeric organic supports, soluble polymeric supports, ionic liquids and fluorous phases are discussed.

  7. {open_quotes}Quadrupoled{close_quotes} materials for second-order nonlinear optics

    Energy Technology Data Exchange (ETDEWEB)

    Hubbard, S.F.; Petschek, R.G.; Singer, K.D. [Case Western Reserve Univ., Cleveland, OH (United States). Dept. of Physics] [and others

    1997-10-01

    We describe a new approach to second-order nonlinear optical materials, namely quadrupoling. This approach is valid in the regime of Kleinman (full permutation) symmetry breaking, and thus requires a two- or three dimensional microscopic nonlinearity at wavelengths away from material resonances. This {open_quotes}quadrupolar{close_quotes} nonlinearity arises from the second rank pseudotensor of the rotationally invariant representation of the second-order nonlinear optical tensor. We have experimentally investigated candidate molecules comprised of chiral camphorquinone derivatives by measuring the scalar invariant associated with the rank two pseudotensor using hyper-Rayleigh scattering. We have found sizable scalar figures of merit for several compounds using light for which the second harmonic wavelengths are greater than 100 nm longer than the absorption peak location. At these wavelengths, the quadrupolar scalar is as large as the polar (EFISH) scalar of p-nitroaniline. Prospects for applications are discussed.

  8. Summary report of working group 2 on {open_quotes}Beam Production{close_quotes}

    Energy Technology Data Exchange (ETDEWEB)

    Serafini, Luca [INFN and Universita di Milano Via Celoria 16, 20133Milano (Italy)] Cornacchia, Max [SSRL---Stanford Linear Accelerator Center, Stanford, California94309 (United States)

    1997-06-01

    We summarize here the discussions and the communications presented in the working group on {open_quotes}Beam Production{close_quotes}, whose main aim was actually focused on identification of main processes limiting the maximum achievable electron beam brightness at injection into the undulator of a generic linac-based X-Ray single pass FEL. These processes have been divided into three main categories: stochastic effects in the photoelectric emission at the cathode, emittance degradation due to space charge effects in the injector, coherent spontaneous emission in bends ({ital e.g.} magnetic compressors) and its related impact on the emittance and/or peak current budget. {copyright} {ital 1997 American Institute of Physics.}

  9. Status of {open_quotes}Nirvana{close_quotes}: High quality GUI based software for HEP

    Energy Technology Data Exchange (ETDEWEB)

    Edel, M.; Kryiakopulos, J.; Lebrun, P.; Kallenbach, J.; Ravoor, S. [Fermi National Accelerator Lab., Batavia, IL (United States); Iourcha, K. [Petersburg Nuclear Physics Institute, Gatchina (Russian Federation)

    1994-12-31

    The Fermilab {open_quotes}Nirvana{close_quotes} project has produced a number of tools for data analysis in High Energy Physics. The authors goal has been to produce software which takes maximum advantage of the workstation graphical user interface. Histo-Scope and NPlot enable users to browse data from running programs and HBOOK, Histo-Scope, and columnar text files. They also provide highly interactive two and three dimensional plots which can be rotated, scaled and adjusted directly with the workstation mouse. The newest program, NFit, a GUI version of the MINUIT fitting program, will be ready in a few months. In addition, NEdit, the programmer`s text editor, was released as public domain in December. The authors discuss the basics of these software products, as well as improvements in the newest versions of Histo-Scope, NPlot, and NEdit.

  10. Research on Open-Closed-Loop Iterative Learning Control with Variable Forgetting Factor of Mobile Robots

    Directory of Open Access Journals (Sweden)

    Hongbin Wang

    2016-01-01

    Full Text Available We propose an iterative learning control algorithm (ILC that is developed using a variable forgetting factor to control a mobile robot. The proposed algorithm can be categorized as an open-closed-loop iterative learning control, which produces control instructions by using both previous and current data. However, introducing a variable forgetting factor can weaken the former control output and its variance in the control law while strengthening the robustness of the iterative learning control. If it is applied to the mobile robot, this will reduce position errors in robot trajectory tracking control effectively. In this work, we show that the proposed algorithm guarantees tracking error bound convergence to a small neighborhood of the origin under the condition of state disturbances, output measurement noises, and fluctuation of system dynamics. By using simulation, we demonstrate that the controller is effective in realizing the prefect tracking.

  11. Numerical modeling of cold room's hinged door opening and closing processes

    Science.gov (United States)

    Carneiro, R.; Gaspar, P. D.; Silva, P. D.; Domingues, L. C.

    2016-06-01

    The need of rationalize energy consumption in agrifood industry has fasten the development of methodologies to improve the thermal and energy performances of cold rooms. This paper presents a three-dimensional (3D) transient Computational Fluid Dynamics (CFD) modelling of a cold room to evaluate the air infiltration rate through hinged doors. A species transport model is used for modelling the tracer gas concentration decay technique. Numerical predictions indicate that air temperature difference between spaces affects the air infiltration. For this case study, the infiltration rate increases 0.016 m3 s-1 per K of air temperature difference. The knowledge about the evolution of air infiltration during door opening/closing times allows to draw some conclusions about its influence on the air conditions inside the cold room, as well as to suggest best practices and simple technical improvements that can minimize air infiltration, and consequently improve thermal performance and energy consumption rationalization.

  12. Control of Energy Density inside a Disordered Medium by Coupling to Open or Closed Channels

    Science.gov (United States)

    Sarma, Raktim; Yamilov, Alexey G.; Petrenko, Sasha; Bromberg, Yaron; Cao, Hui

    2016-08-01

    We demonstrate experimentally the efficient control of light intensity distribution inside a random scattering system. The adaptive wave front shaping technique is applied to a silicon waveguide containing scattering nanostructures, and the on-chip coupling scheme enables access to all input spatial modes. By selectively coupling the incident light to the open or closed channels of the disordered system, we not only vary the total energy stored inside the system by a factor of 7.4, but also change the energy density distribution from an exponential decay to a linear decay and to a profile peaked near the center. This work provides an on-chip platform for controlling light-matter interactions in turbid media.

  13. High-throughput metagenomic technologies for complex microbial community analysis: open and closed formats.

    Science.gov (United States)

    Zhou, Jizhong; He, Zhili; Yang, Yunfeng; Deng, Ye; Tringe, Susannah G; Alvarez-Cohen, Lisa

    2015-01-27

    Understanding the structure, functions, activities and dynamics of microbial communities in natural environments is one of the grand challenges of 21st century science. To address this challenge, over the past decade, numerous technologies have been developed for interrogating microbial communities, of which some are amenable to exploratory work (e.g., high-throughput sequencing and phenotypic screening) and others depend on reference genes or genomes (e.g., phylogenetic and functional gene arrays). Here, we provide a critical review and synthesis of the most commonly applied "open-format" and "closed-format" detection technologies. We discuss their characteristics, advantages, and disadvantages within the context of environmental applications and focus on analysis of complex microbial systems, such as those in soils, in which diversity is high and reference genomes are few. In addition, we discuss crucial issues and considerations associated with applying complementary high-throughput molecular technologies to address important ecological questions.

  14. Open and closed lip schizencephaly in Seckel syndrome: a case report.

    Science.gov (United States)

    Thapa, Rajoo; Mallick, Debkrishna; Biswas, Biswajit; Ghosh, Apurba

    2010-04-01

    Seckel syndrome (Online Mendelian Inheritance in Man database Number 210600) is the classic prototype of primordial bird-headed dwarfism. In addition to the characteristic craniofacial dysmorphism and skeletal defects, abnormalities of the cardiovascular, hematopoietic, endocrine, and central nervous systems are described. The full phenotypic spectrum of this clinically and genetically heterogeneous syndrome is yet to be delineated. Presented herein is a boy 2 years and 5 months old, with Seckel syndrome, born to second-degree consanguineous Muslim parents. In addition to the classic phenotype of the disorder, this patient had both, an open and a closed lip schizencephaly detected on cranial computed tomography (CT) scan. To our knowledge, the association of schizencephaly and Seckel syndrome is not described previously in the English language literature. In addition, presented briefly is a review of the anatomical cerebral cortical malformations associated with this syndrome.

  15. Electron ionization of open/closed chain isocarbonic molecules relevant in plasma processing: Theoretical cross sections

    Energy Technology Data Exchange (ETDEWEB)

    Patel, Umang R., E-mail: umangpatel193@yahoo.ca [Gandhinagar Institute of Technology, Moti Bhoyan, Gandhinagar-382721, Gujarat (India); Sardar Patel University, Vallabh Vidyanagar-388120, Gujarat (India); Joshipura, K. N.; Pandya, Siddharth H. [Sardar Patel University, Vallabh Vidyanagar-388120, Gujarat (India); Kothari, Harshit N. [Universal College of Engineering and Technology, Moti Bhoyan, Gandhinagar-382721, Gujarat (India)

    2014-01-28

    In this paper, we report theoretical electron impact ionization cross sections from threshold to 2000 eV for isocarbonic open chain molecules C{sub 4}H{sub 6}, C{sub 4}H{sub 8}, C{sub 4}F{sub 6} including their isomers, and closed chain molecules c-C{sub 4}H{sub 8} and c-C{sub 4}F{sub 8}. Theoretical formalism employed presently, viz., Complex Scattering Potential-ionization contribution method has been used successfully for a variety of polyatomic molecules. The present ionization calculations are very important since results available for the studied targets are either scarce or none. Our work affords comparison of C{sub 4} containing hydrocarbon versus fluorocarbon molecules. Comparisons of the present ionization cross sections are made wherever possible, and new ionization data are also presented.

  16. Open and closed loop manipulation of charged microchiplets in an electric field

    Energy Technology Data Exchange (ETDEWEB)

    Lu, J. P., E-mail: jplu@parc.com; Thompson, J. D.; Whiting, G. L.; Biegelsen, D. K.; Raychaudhuri, S.; Lujan, R.; Veres, J.; Lavery, L. L.; Völkel, A. R.; Chow, E. M. [Palo Alto Research Center, Inc., 3333 Coyote Hill Rd., Palo Alto, California 94304 (United States)

    2014-08-04

    We demonstrate the ability to orient, position, and transport microchips (“chiplets”) with electric fields. In an open-loop approach, modified four phase traveling wave potential patterns manipulate chiplets in a dielectric solution using dynamic template agitation techniques. Repeatable parallel assembly of chiplets is demonstrated to a positional accuracy of 6.5 μm using electrodes of 200 μm pitch. Chiplets with dipole surface charge patterns are used to show that orientation can be controlled by adding unique charge patterns on the chiplets. Chip path routing is also demonstrated. With a closed-loop control system approach using video feedback, dielectric, and electrophoretic forces are used to achieve positioning accuracy of better than 1 μm with 1 mm pitch driving electrodes. These chip assembly techniques have the potential to enable future printer systems where inputs are electronic chiplets and the output is a functional electronic system.

  17. Characterization and restoration of performance of {open_quotes}aged{close_quotes} radioiodine removing activated carbons

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, W.P. [NUCON International, Inc., Columbus, OH (United States)

    1997-08-01

    The degradation of radioiodine removal performance for impregnated activated carbons because of ageing is well established. However, the causes for this degradation remain unclear. One theory is that this reduction in performance from the ageing process results from an oxidation of the surface of the carbon. Radioiodine removing activated carbons that failed radioiodine removal tests showed an oxidized surface that had become hydrophilic compared with new carbons. We attempted to restore the performance of these {open_quotes}failed{close_quotes} carbons with a combination of thermal and chemical treatment. The results of these investigations are presented and discussed with the view of extending the life of radioiodine removing activated carbons. 4 refs., 2 tabs.

  18. Body height, estimated cerebrospinal fluid pressure and open-angle glaucoma. The Beijing Eye Study 2011.

    Directory of Open Access Journals (Sweden)

    Jost B Jonas

    Full Text Available PURPOSE: To examine potential associations between body height, cerebrospinal fluid pressure (CSFP, trans-lamina cribrosa pressure difference (TLCPD and prevalence of open-angle glaucoma (OAG in a population-based setting. METHODS: The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6 ± 9.8 years (range:50-93 years. A detailed ophthalmic examination was performed. Based on a previous study with lumbar cerebrospinal fluid pressure (CSFP measurements, CSFP was calculated as CSFP[mmHg] = 0.44 × Body Mass Index[kg/m(2] + 0.16 × Diastolic Blood Pressure[mmHg]-0.18 × Age[Years]-1.91. RESULTS: Data of IOP and CSFP were available for 3353 (96.7% subjects. Taller body height was associated with higher CSFP (P<0.001; standardized correlation coefficient beta:0.13; regression coefficient B:0.29; 95% confidence interval (CI:0.25,0.33 after adjusting for male gender, urban region of habitation, higher educational level, and pulse rate. If TLCPD instead of CSFP was added, taller body height was associated with lower TLCPD (P<0.001;beta:-0.10;B:-0.20;95%CI:-0.25,-0.15. Correspondingly, higher CSFP was associated with taller body height (P = 0.003;beta:0.02;B:0.01;95%CI:0.00,0.02, after adjusting for age, gender, body mass index, pulse, systolic blood pressure, and blood concentration of cholesterol. If IOP was added to the model, higher CSFP was associated with higher IOP (P<0.001;beta:0.02;B:0.02;95%CI:0.01,0.03. TLCPD was associated with lower body height (P = 0.003;beta:-0.04;B -0.02,95%CI:-0.04,-0.01 after adjusting for age, body mass index, systolic blood pressure, pulse, blood concentrations of triglycerides, axial length, central corneal thickness, corneal curvature radius, and anterior chamber depth. Adding the prevalence of OAG to the multivariate analysis revealed, that taller body height was associated with a lower OAG prevalence (P = 0.03;beta:-0.03;B:-1.20;95%CI:-2.28,-0.12 after adjusting for

  19. Recovery of mouth-opening after closed treatment of a fracture of the mandibular condyle : a longitudinal study

    NARCIS (Netherlands)

    Niezen, E. T.; Stuive, I.; Post, W. J.; Bos, R. R. M.; Dijkstra, P. U.

    2015-01-01

    The aim of this retrospective study was to assess recovery of mouth opening after closed treatment of fractures of the mandibular condyle, and analyse which characteristics might influence recovery. We measured mouth opening in 142 patients (mean (SD) age 30 (14) years, 96 of whom were male) during

  20. Transcription closed and open complex dynamics studies reveal balance between genetic determinants and co-factors.

    Science.gov (United States)

    Sala, Adrien; Shoaib, Muhammad; Anufrieva, Olga; Mutharasu, Gnanavel; Jahan Hoque, Rawnak; Yli-Harja, Olli; Kandhavelu, Meenakshisundaram

    2015-05-19

    In E. coli, promoter closed and open complexes are key steps in transcription initiation, where magnesium-dependent RNA polymerase catalyzes RNA synthesis. However, the exact mechanism of initiation remains to be fully elucidated. Here, using single mRNA detection and dual reporter studies, we show that increased intracellular magnesium concentration affects Plac initiation complex formation resulting in a highly dynamic process over the cell growth phases. Mg2+ regulates transcription transition, which modulates bimodality of mRNA distribution in the exponential phase. We reveal that Mg2+ regulates the size and frequency of the mRNA burst by changing the open complex duration. Moreover, increasing magnesium concentration leads to higher intrinsic and extrinsic noise in the exponential phase. RNAP-Mg2+ interaction simulation reveals critical movements creating a shorter contact distance between aspartic acid residues and Nucleotide Triphosphate residues and increasing electrostatic charges in the active site. Our findings provide unique biophysical insights into the balanced mechanism of genetic determinants and magnesium ion in transcription initiation regulation during cell growth.

  1. To open or to close: species-specific stomatal responses to simultaneously applied opposing environmental factors.

    Science.gov (United States)

    Merilo, Ebe; Jõesaar, Indrek; Brosché, Mikael; Kollist, Hannes

    2014-04-01

    Plant stomatal responses to single environmental factors are well studied; however, responses to a change in two (or more) factors - a common situation in nature - have been less frequently addressed. We studied the stomatal responses to a simultaneous application of opposing environmental factors in six evolutionarily distant mono- and dicotyledonous herbs representing different life strategies (ruderals, competitors and stress-tolerators) to clarify whether the crosstalk between opening- and closure-inducing pathways leading to stomatal response is universal or species-specific. Custom-made gas exchange devices were used to study the stomatal responses to a simultaneous application of two opposing factors: decreased/increased CO2 concentration and light availability or reduced air humidity. The studied species responded similarly to changes in single environmental factors, but showed species-specific and nonadditive responses to two simultaneously applied opposing factors. The stomata of the ruderals Arabidopsis thaliana and Thellungiella salsuginea (previously Thellungiella halophila) always opened, whereas those of competitor-ruderals either closed in all two-factor combinations (Triticum aestivum), remained relatively unchanged (Nicotiana tabacum) or showed a response dominated by reduced air humidity (Hordeum vulgare). Our results, indicating that in changing environmental conditions species-specific stomatal responses are evident that cannot be predicted from studying one factor at a time, might be interesting for stomatal modellers, too.

  2. Geneva Festival, 2004: Opened with the Big Bang, closed with Creation

    CERN Multimedia

    2004-01-01

    In its 50th Anniversary year, CERN had the honour of opening and closing this year's Geneva Festival. The Geneva Festival traditionally opens with a bang, but this year's was the biggest yet. On 30 July, on a warm summer's evening by Lake Geneva, several tons of fireworks replayed the early history of the Universe. Starting with the Big Bang, the display had acts representing inflation, the breaking of symmetries, the clash of antimatter and matter, hadrons and nucleosynthesis, the first atoms and the Universe becoming transparent, and the formation of stars and planets. It was a challenge to translate these very abstract ideas into more than a thousand kilograms of TNT of different colour. But, set to the music of The Matrix, Alan Parsons, and Jurassic Park, one of the most spectacular physics presentations ever staged dazzled the audience of two hundred thousand spectators. CERN physicist Rolf Landua, who scripted the narrative and worked with the pyrotechnicians on the realization, said: "From the many e...

  3. Population Shift between the Open and Closed States Changes the Water Permeability of an Aquaporin Z Mutant

    DEFF Research Database (Denmark)

    Xin, Lin; Helix Nielsen, Claus; Su, Haibin;

    2012-01-01

    gate in the triple mutant with R189 as the primary steric gate in both mutant and WT AqpZ. The double gates (R189 and W43-F183) result in a high population of the closed conformation in the mutant. Occasionally an open state, with diffusive water permeability very close to that of WT AqpZ, was observed...

  4. Localization and traces in open-closed topological Landau-Ginzburg models

    Energy Technology Data Exchange (ETDEWEB)

    Herbst, Manfred [Department of Physics, CERN, Theory Division, CH-1211 Geneva 23 (Switzerland); Lazaroiu, Calin-Iuliu [5243 Chamberlin Hall, University of Wisconsin at Madison, 1150 University Ave, Madison, Wisconsin 53706 (United States)

    2005-05-01

    We reconsider the issue of localization in open-closed B-twisted Landau-Ginzburg models with arbitrary Calabi-Yau target. Through careful analysis of zero-mode reduction, we show that the closed model allows for a one-parameter family of localization pictures, which generalize the standard residue representation. The parameter {lambda} which indexes these pictures measures the area of worldsheets with S {sup 2} topology, with the residue representation obtained in the limit of small area. In the boundary sector, we find a double family of such pictures, depending on parameters {lambda} and {mu} which measure the area and boundary length of worldsheets with disk topology. We show that setting {mu} = 0 and varying {lambda} interpolates between the localization picture of the B-model with a noncompact target space and a certain residue representation proposed recently. This gives a complete derivation of the boundary residue formula, starting from the explicit construction of the boundary coupling. We also show that the various localization pictures are related by a semigroup of homotopy equivalences.

  5. Ferromagnetic resonance and resonance modes in kagome lattices: From an open to a closed kagome structure

    Science.gov (United States)

    Dubowik, J.; Kuświk, P.; Matczak, M.; Bednarski, W.; Stobiecki, F.; Aleshkevych, P.; Szymczak, H.; Kisielewski, M.; Kisielewski, J.

    2016-06-01

    We present ferromagnetic resonance (FMR) investigations of 20 nm thick permalloy (Ni80Fe20 ) elements (width W =200 nm, length L =470 nm, period a =500 nm) arranged in open and closed artificial kagome lattices. The measurements were done at 9.4 and 34 GHz to ensure a saturated or near-saturated magnetic state of the kagome structures. The FMR data are analyzed in the framework of an analytical macrospin model which grasps the essential features of the bulk and edge modes at these microwave frequencies and is in agreement with the results of micromagnetic simulations. Polar plots of the resonance fields versus the field angle made by the direction of the magnetic field with respect to the main symmetry directions of the kagome lattice are compared with the results of the analytical model. The measured FMR spectra with a sixfold rotational symmetry qualitatively reproduce the structure expected from the theory. Magnetic dipolar interactions between the elements of the kagome lattices result in the mixing of edge and bulklike excitations at 9.4 GHz and in a systematic deviation from the model, especially for the closed kagome lattice.

  6. Groundwater Discharge into Intermittently Closed and Open Lakes and/or Lagoons (ICOLLs) via Radon-222

    Science.gov (United States)

    Sadat-Noori, M.; Santos, I. R.; Tait, D. R.; McMahon, A.; Kadel, S.; Maher, D. T.

    2015-12-01

    Intermittently Closed and Open Lakes and Lagoons (ICOLLs) are brackish coastal water bodies with an intermittent connection to the ocean that is closed periodically due to the accumulation of marine sediment forming an entrance berm. ICOLLs have dynamic coastal systems that may be vulnerable to minor changes in catchment hydrology. However, little is known regarding the impacts of groundwater on the hydrological cycles of ICOLLs. The relative contribution of rainfall versus groundwater discharge in two ICOLLs (Welsby, and Mermaid Lagoon) and a nearby wetland (South Welsby Lagoon) located on Bribie Island (Australia) were investigated using radon (222Rn) as natural geochemical groundwater tracer. Four seasonal surveys were undertaken to quantify the temporal and spatial groundwater dynamics of the ICOLLs. Radon contour maps revealed temporal and spatial changes over the study period. The estimated groundwater discharge rates from a radon-mass balance were 3.4±3.1, 7.3±9.8 and 2.6±3.8 cm d-1 in Weslby, South Weslby and Mermaid Lagoons, respectively. These values are at least 8-fold greater than rainfall (1420 mm per year, or 0.4 cm d-1). Assuming very minor surface water flows (not perceived during field surveys), this demonstrates that these systems are groundwater-dominated and their hydrology can be influenced by regional changes in groundwater level.

  7. Conceptualization and validation of an open-source closed-loop deep brain stimulation system in rat.

    Science.gov (United States)

    Wu, Hemmings; Ghekiere, Hartwin; Beeckmans, Dorien; Tambuyzer, Tim; van Kuyck, Kris; Aerts, Jean-Marie; Nuttin, Bart

    2015-04-21

    Conventional deep brain stimulation (DBS) applies constant electrical stimulation to specific brain regions to treat neurological disorders. Closed-loop DBS with real-time feedback is gaining attention in recent years, after proved more effective than conventional DBS in terms of pathological symptom control clinically. Here we demonstrate the conceptualization and validation of a closed-loop DBS system using open-source hardware. We used hippocampal theta oscillations as system input, and electrical stimulation in the mesencephalic reticular formation (mRt) as controller output. It is well documented that hippocampal theta oscillations are highly related to locomotion, while electrical stimulation in the mRt induces freezing. We used an Arduino open-source microcontroller between input and output sources. This allowed us to use hippocampal local field potentials (LFPs) to steer electrical stimulation in the mRt. Our results showed that closed-loop DBS significantly suppressed locomotion compared to no stimulation, and required on average only 56% of the stimulation used in open-loop DBS to reach similar effects. The main advantages of open-source hardware include wide selection and availability, high customizability, and affordability. Our open-source closed-loop DBS system is effective, and warrants further research using open-source hardware for closed-loop neuromodulation.

  8. Open-Book Tests to Complement Assessment-Programmes: Analysis of Open and Closed-Book Tests

    Science.gov (United States)

    Heijne-penninga, M.; Kuks, J. B. M.; Schonrock-adema, J.; Snijders, T. A. B.; Cohen-schotanus, J.

    2008-01-01

    Today's health sciences educational programmes have to deal with a growing and changing amount of knowledge. It is becoming increasingly important for students to be able to use and manage knowledge. We suggest incorporating open-book tests in assessment programmes to meet these changes. This view on the use of open-book tests is discussed and the…

  9. Total knee arthroplasty after failed high tibial osteotomy: a systematic review of open versus closed wedge osteotomy.

    Science.gov (United States)

    Han, Jae Hwi; Yang, Jae-Hyuk; Bhandare, Nikhl N; Suh, Dong Won; Lee, Jong Seong; Chang, Yong Suk; Yeom, Ji Woong; Nha, Kyung Wook

    2016-08-01

    Medial opening wedge high tibial osteotomy (HTO) has become increasingly popular as an alternative to lateral closing wedge osteotomy for the treatment of medial compartment knee osteoarthritis with varus deformity. The present systematic review was conducted to provide an objective analysis of total knee arthroplasty (TKA) outcomes following previous knee osteotomy (medial opening wedge vs. lateral closing wedge). A literature search of online databases (MEDLINE, EMBASE, Cochrane Library database) was made, in addition to manual search of major orthopaedic journals. The methodological quality of each of the studies was assessed on the Newcastle-Ottawa Scale and Effective Practice and Organization of Care. A total of ten studies were included in the review. There were eight studies with Level IV and two studies with Level III evidence. Eight studies reported clinical and radiologic scores. Comparative studies between TKA following medial opening and lateral closing wedge HTO did not demonstrate statistically significant clinical and radiologic differences. The revision rates were similar. However, more technical issues during TKA surgery after lateral closing wedge HTO were mentioned than the medial open wedge group. The quadriceps snip, tibial tubercle osteotomy, and lateral soft tissue release were more frequently needed in the lateral closing wedge HTO group. In addition, because of loss of proximal tibia bone geometry in the lateral closing wedge HTO group, concerns such as tibia stem impingement in the lateral tibial cortex was noted. The present systematic review suggests that TKA after medial opening and lateral closing wedge HTO showed similar performance. Clinical and radiologic outcome including revision rates did not statistically differ from included studies. However, there are more surgical technical concerns in TKA conversion from lateral closing wedge HTO than from the medial opening wedge HTO group. IV.

  10. Open or closed repositioning of mandibular fractures: is there a difference in healing outcome? A systematic review

    DEFF Research Database (Denmark)

    Andreasen, Jens Ove; Storgård Jensen, Simon; Kofod, Thomas

    2008-01-01

    The clinical outcome of closed vs open reduction and rigid fixation was compared based on a systematic review of the literature. Ten non-randomized retrospective studies were found. In six of these ten studies, the complication rate was significantly increased when open reduction and plating...... or wires. Nerve injuries were slightly increased when open reduction was found (although not significant). With regard to occlusal disturbances, no difference was found in the open and closed reduction group. Concerning overall complication problems, six of seven studies showed more problems after open...... in case of more complicated fractures cannot be excluded, which might explain the differences found between the two procedures. Prospective, randomized clinical trials are needed to illuminate this problem....

  11. Knowledge and attitude of eye hospital patients towards chronic open angle glaucoma in Onitsha

    Directory of Open Access Journals (Sweden)

    L O Onyekwe

    2009-01-01

    Conclusion:The study showed that knowledge of glaucoma is still very low in this environment. Fear of visual loss and cost are the major reasons for non-acceptance of surgery as a mode of treatment. The eye care providers should evolve a culture of useful health education and couseling regarding glaucoma, an irreversibly blindness disease.

  12. Spatiotemporal assessment of water chemistry in intermittently open/closed coastal lakes of Southern Baltic

    Science.gov (United States)

    Astel, Aleksander M.; Bigus, Katarzyna; Obolewski, Krystian; Glińska-Lewczuk, Katarzyna

    2016-12-01

    Ionic profile, pH, electrolytic conductivity, chemical oxygen demand and concentration of selected heavy metals (Ni, Cu, Zn, Fe and Mn) were determined in water of 11 intermittently closed and open lakes and lagoons (ICOLLs) located in Polish coastline. Multidimensional data set was explored by the use of the self-organizing map (SOM) technique to avoid supervised and predictable division for fully isolated, partially and fully connected lakes. Water quality assessment based on single parameter's mean value allowed classification of majority of lakes to first or second class of purity according to regulation presenting classification approach applicable to uniform parts of surface waters. The SOM-based grouping revealed seven clusters comprising water samples of similar physico-chemical profile. Fully connected lakes were characterized by the highest concentration of components characteristic for sea salts (NaCl, MgCl2, MgSO4, CaSO4, K2SO4 and MgBr2), however spring samples from Łebsko were shifted to another cluster suggesting that intensive surface run-off and fresh-water inflow through Łupawa river decreases an impact of sea water intrusions. Forecasted characteristic of water collected in Resko Przymorskie lake was disturbed by high contamination by nitrites indicating accidental and local contamination due to usage of sodium nitrite for the curing of meat. Some unexpected sources of contamination was discovered in intermittently open and closed lakes. Presumably Zn contamination is due to use of wood preservatives to protect small wooden playgrounds or camping places spread around one of the lake, while increased concentration of Ni could be connected with grass and vegetation burning. Waters of Jamno lake are under the strongest anthropogenic impact due to inefficient removal of phosphates by waste water treatment plant and contamination by Fe and Mn caused by backwashing of absorption filters. Generally, the quality of ICOLLs' water was diversified, while

  13. Comparison of Dimensional Accuracy between Open-Tray and Closed-Tray Implant Impression Technique in 15° Angled Implants

    Directory of Open Access Journals (Sweden)

    Balouch F.

    2013-09-01

    Full Text Available Statement of Problem: Various impression techniques have different effects on the accuracy of final cast dimensions. Meanwhile; there are some controversies about the best technique. Purpose: This study was performed to compare two kinds of implant impression methods (open tray and closed tray on 15 degree angled implants.Materials and Method: In this experimental study, a steel model with 8 cm in diameter and 3 cm in height were produced with 3 holes devised inside to stabilize 3 implants. The central implant was straight and the other two implants were 15° angled. The two angled implants had 5 cm distance from each other and 3.5 cm from the central implant. Dental stone, high strength (type IV was used for the main casts. Impression trays were filled with poly ether, and then the two impression techniques (open tray and closed tray were compared. To evaluate positions of the implants, each cast was analyzed by CMM device in 3 dimensions (x,y,z. Differences in the measurements obtained from final casts and laboratory model were analyzed using t-Test. Results: The obtained results indicated that closed tray impression technique was significantly different in dimensional accuracy when compared with open tray method. Dimensional changes were 129 ± 37μ and 143.5 ± 43.67μ in closed tray and open tray, while coefficient of variation in closed- tray and open tray were reported to be 27.2% and 30.4%, respectively.Conclusion: Closed impression technique had less dimensional changes in comparison with open tray method, so this study suggests that closed tray impression technique is more accurate.

  14. Numerical model describing optimization of fibres winding process on open and closed frame

    Science.gov (United States)

    Petrů, M.; Mlýnek, J.; Martinec, T.

    2016-08-01

    This article discusses a numerical model describing optimization of fibres winding process on open and closed frame. The quality production of said type of composite frame depends primarily on the correct winding of fibers on a polyurethane core. It is especially needed to ensure the correct angles of the fibers winding on the polyurethane core and the homogeneity of individual winding layers. The article describes mathematical model for use an industrial robot in filament winding and how to calculate the trajectory of the robot. When winding fibers on the polyurethane core which is fastened to the robot-end-effector so that during the winding process goes through a fibre-processing head on the basis of the suitably determined robot-end-effector trajectory. We use the described numerical model and matrix calculus to enumerate the trajectory of the robot-end-effector to determine the desired passage of the frame through the fibre-processing head. The calculation of the trajectory was programmed in the Delphi development environment. Relations of the numerical model are important for use a real solving of the passage of a polyurethane core through fibre-processing head.

  15. In-medium similarity renormalization group for closed and open-shell nuclei

    Science.gov (United States)

    Hergert, H.

    2017-02-01

    We present a pedagogical introduction to the in-medium similarity renormalization group (IMSRG) framework for ab initio calculations of nuclei. The IMSRG performs continuous unitary transformations of the nuclear many-body Hamiltonian in second-quantized form, which can be implemented with polynomial computational effort. Through suitably chosen generators, it is possible to extract eigenvalues of the Hamiltonian in a given nucleus, or drive the Hamiltonian matrix in configuration space to specific structures, e.g., band- or block-diagonal form. Exploiting this flexibility, we describe two complementary approaches for the description of closed- and open-shell nuclei: the first is the multireference IMSRG (MR-IMSRG), which is designed for the efficient calculation of nuclear ground-state properties. The second is the derivation of non-empirical valence-space interactions that can be used as input for nuclear shell model (i.e., configuration interaction (CI)) calculations. This IMSRG+shell model approach provides immediate access to excitation spectra, transitions, etc, but is limited in applicability by the factorial cost of the CI calculations. We review applications of the MR-IMSRG and IMSRG+shell model approaches to the calculation of ground-state properties for the oxygen, calcium, and nickel isotopic chains or the spectroscopy of nuclei in the lower sd shell, respectively, and present selected new results, e.g., for the ground- and excited state properties of neon isotopes.

  16. Birth of Closed Strings and Death of Open Strings during Tachyon Condensation

    CERN Document Server

    Hashimoto, K; Wang, J E; Hashimoto, Koji; Ho, Pei-Ming; Wang, John E.

    2004-01-01

    The tremendous progress achieved through the study of black holes and branes suggests that their time dependent generalizations called Spacelike branes (S-branes) may prove similarly useful. An example of an established approach to S-branes is to include a string boundary interaction and we first summarize evidence for the death of open string degrees of freedom for the homogeneous rolling tachyon on a decaying brane. Then, we review how to extract the flat S-brane worldvolumes describing the homogeneous rolling tachyon and how large deformations correspond to creation of lower dimensional strings and branes. These S-brane worldvolumes are governed by S-brane actions which are on equal footing to D-brane actions, since they are derived by imposing conformality on the string worldsheet, as well as by analyzing fluctuations of time dependent tachyon configurations. As further examples we generalize previous solutions of the S-brane actions so as to describe multiple decaying and nucleating closed fundamental st...

  17. Broadly Neutralizing Antibody 8ANC195 Recognizes Closed and Open States of HIV-1 Env.

    Science.gov (United States)

    Scharf, Louise; Wang, Haoqing; Gao, Han; Chen, Songye; McDowall, Alasdair W; Bjorkman, Pamela J

    2015-09-10

    The HIV-1 envelope (Env) spike contains limited epitopes for broadly neutralizing antibodies (bNAbs); thus, most neutralizing antibodies are strain specific. The 8ANC195 epitope, defined by crystal and electron microscopy (EM) structures of bNAb 8ANC195 complexed with monomeric gp120 and trimeric Env, respectively, spans the gp120 and gp41 Env subunits. To investigate 8ANC195's gp41 epitope at higher resolution, we solved a 3.58 Å crystal structure of 8ANC195 complexed with fully glycosylated Env trimer, revealing 8ANC195 insertion into a glycan shield gap to contact gp120 and gp41 glycans and protein residues. To determine whether 8ANC195 recognizes the CD4-bound open Env conformation that leads to co-receptor binding and fusion, one of several known conformations of virion-associated Env, we solved EM structures of an Env/CD4/CD4-induced antibody/8ANC195 complex. 8ANC195 binding partially closed the CD4-bound trimer, confirming structural plasticity of Env by revealing a previously unseen conformation. 8ANC195's ability to bind different Env conformations suggests advantages for potential therapeutic applications.

  18. Orbital Feshbach resonances with a small energy gap between open and closed channels

    Science.gov (United States)

    Cheng, Yanting; Zhang, Ren; Zhang, Peng

    2016-04-01

    Recently, a new type of Feshbach resonance, i.e., orbital Feshbach resonance (OFR), was proposed for the ultracold alkaline-earth-metal-like atoms and was experimentally observed in the ultracold gases of 173Yb atoms. Unlike most of the magnetic Feshbach resonances of ultracold alkali atoms, when the OFR of 173Yb atoms appears, the energy gap between the thresholds of the open channel (OC) and the closed channel (CC) is much smaller than the characteristic energy of the interatomic interaction, i.e., the van der Waals energy. In this paper we study the OFR in systems with a small CC-OC threshold gap. We show that in these systems the OFR can be induced by the coupling between the OC and either an isolated bound state of the CC or the scattering states of the CC. Moreover, we also show that in each case the two-channel Huang-Yang pesudopotential is always applicable for the approximate calculation of the low-energy scattering amplitude. Our results imply that in the two-channel theoretical calculations for these systems it is appropriate to take into account the contributions from the scattering states of the CC.

  19. Tandem ring-opening/ring-closing metathesis polymerization: relationship between monomer structure and reactivity.

    Science.gov (United States)

    Park, Hyeon; Lee, Ho-Keun; Choi, Tae-Lim

    2013-07-24

    Monomers containing either cycloalkenes with low ring strain or 1-alkynes are poor monomers for olefin metathesis polymerization. Ironically, keeping two inactive functional groups in proximity within one molecule can make it an excellent monomer for metathesis polymerization. Recently, we demonstrated that monomer 1 having cyclohexene and propargyl moieties underwent rapid tandem ring-opening/ring-closing metathesis (RO/RCM) polymerization via relay-type mechanism. Furthermore, living polymerization was achieved when a third-generation Grubbs catalyst was used. Here, we present a full account on this tandem polymerization by investigating how various structural modifications of the monomers affected the reactivity of the tandem polymerization. We observed that changing the ring size of the cycloalkene moieties, the length of the alkynes, and linker units influenced not only the polymerization rates but also the reactivities of Diels-Alder reaction, which is a post-modification reaction of the resulting polymers. Also, the mechanism of tandem polymerization was studied by conducting end-group analysis using (1)H NMR analysis, thereby concluding that the polymerization occurred by the alkyne-first pathway. With this mechanistic conclusion, factors responsible for the dramatic structure-reactivity relationship were proposed. Lastly, tandem RO/RCM polymerization of monomers containing sterically challenging trisubstituted cycloalkenes was successfully carried out to give polymer repeat units having tetrasubstituted cycloalkenes.

  20. Myth-building: The [open quotes]Islamic[close quotes] bomb

    Energy Technology Data Exchange (ETDEWEB)

    Hoodbhoy, P. (Quadi-e-Azam Univ., Islamabad (Pakistan))

    1993-06-01

    The [open quotes]Islamic Bomb[close quotes] is roughly understood to be a nuclear weapon aquired for broad ideological reasons--a weapon that supposedly belongs to the Muslim [ital ummah] or community and, as such, is the ultimate expression of Islamic solidarity. Concern about the Islamic bomb is at the heart of the intense effort to prevent the spread of nuclear weapons to Muslim countries. The official justification is a general one: proliferation must be curbed globally. But unofficially, the Islamic bomb gets special attention. The reasons behind this special attention are described in this article. The reasons include fear of terrorism, of a [ital jihad] willing to indiscriminately use nuclear weapons in hope of a reward in the Hereafter, and of the transfer of nuclear arms from nuclear to non-nuclear Muslim countries in times of crisis. Possibilities for controlling the proliferation of nuclear weapons in Muslim countries are addressed. Reasons are cited as to why various Muslim countries wish to acquire nuclear weapons.

  1. Safety and efficiency keys to {open_quotes}surgeless blower{close_quotes}

    Energy Technology Data Exchange (ETDEWEB)

    Banyay, H.D.; Gutzwiller, L.

    1997-01-01

    When exhausting combustible hydrocarbon vapors form sea-going tankers, vapor recovery systems must be spark resistant and gas tight while maintaining stable operation over a wide flow range and minimizing noise, resisting corrosion and providing low maintenance. A {open_quotes}surgeless blower{close_quotes} has met these challenges in 17 US marine vapor emission control systems. The blower, which mounts on a dock, helps move vapors emitted during tanker loading from the tankers through long exhaust ducts to processing plants. The duct-work typically included valves, detonation arresters and other components that increase resistance to gas flow. The volume flow requirement of the exhaust system varies widely depending on the loading rate. A high-pressure blower is therefore needed to allow for a wide range of operating volumes-from 100 CFM to 13,000 CFM-without causing instability or surging. The materials used to construct blowers must be corrosion resistant on inside surfaces to withstand the corrosive effects of hydrocarbon vapor and outside surfaces to operate in the salt-spray environment of seaside docks.

  2. Portable Low-Frequency Noise Reduction Device for Both Small Open and Closed Spaces

    Directory of Open Access Journals (Sweden)

    Chao Wang

    2016-01-01

    Full Text Available Noise pollution has been given more attention due to its negative impacts on human health and disease. The portable low-frequency noise reduction device we developed in this research can provide an effective way for solving low-frequency noise pollution problem in the small space. This work describes the design principle and the prototype structures for two versions of V1.5 and V2.0 and builds the noise test systems for small spaces, respectively. These devices, installed on the outer surface of the small spaces, can automatically identify the noise spectrum and implement noise reduction by means of the active noise control (ANC technology. The testing results indicate that the noise can be reduced 12 dB in the range of 250 Hz~400 Hz for the small closed space while, for the small open space, the best effect of 5.88 dB occurs in the optimal frequency of 450 Hz. These effects will be weakened with the increasing distance away from the source and show the obvious axisymmetric distribution in the inverted cone space.

  3. The open-plus-closed loop (OPCL) method for chaotic systems with multiple strange attractors

    Institute of Scientific and Technical Information of China (English)

    Song Yun-Zhong

    2007-01-01

    Based on the open-plus-closed-loop (OPCL) control method a systematic and comprehensive controller is presented in this paper for a chaotic system, that is, the Newton-Leipnik equation with two strange attractors: the upper attractor(UA) and the lower attractor (LA). Results show that the final structure of the suggested controller for stabilization has a simple linear feedback form. To keep the integrity of the suggested approach, the globality proof of the basins of entrainment is also provided. In virtue of the OPCL technique, three different kinds of chaotic controls of the system are investigated, separately: the original control forcing the chaotic motion to settle down to the origin from an arbitrary position of the phase space; the chaotic intra-attractor control for stabilizing the equilibrium points only belonging to the upper chaotic attractor or the lower chaotic one; and the inter-attractor control for compelling the chaotic oscillation from one basin to another one. Both theoretical analysis and simulation results verify the validity of the proposed means.

  4. In-Medium Similarity Renormalization Group for Closed and Open-Shell Nuclei

    CERN Document Server

    Hergert, H

    2016-01-01

    We present a pedagogical introduction to the In-Medium Similarity Renormalization Group (IM-SRG) framework for ab initio calculations of nuclei. The IM-SRG performs continuous unitary transformations of the nuclear many-body Hamiltonian in second-quantized form, which can be implemented with polynomial computational effort. Through suitably chosen generators, it is possible to extract eigenvalues of the Hamiltonian in a given nucleus, or drive the Hamiltonian matrix in configuration space to specific structures, e.g., band- or block-diagonal form. Exploiting this flexibility, we describe two complementary approaches for the description of closed- and open-shell nuclei: The first is the Multireference IM-SRG (MR-IM-SRG), which is designed for the efficient calculation of nuclear ground-state properties. The second is the derivation of nonempirical valence-space interactions that can be used as input for nuclear Shell model (i.e., configuration interaction (CI)) calculations. This IM-SRG+Shell model approach pr...

  5. From hyperons to applied optics: {open_quotes}Winston Cones{close_quotes} during and after ZGS era

    Energy Technology Data Exchange (ETDEWEB)

    Swallow, E.C. [Elmhurst College, IL (United States)]|[Univ. of Chicago, IL (United States)

    1994-12-31

    This paper discusses developments in light collection which had their origin in efforts to construct high performance gas Cerenkov detectors for precision studies of hyperon beta decays at the ZGS. The resulting devices, know generally as {open_quotes}compound parabolic concentrators,{close_quotes} have found applications ranging from nuclear and particle physics experiments to solar energy concentration, instrument illumination, and understanding the optics of visual receptors. Interest in these devices and the ideas underlying them stimulated the development of a substantial new subfield of physics: nonimaging optics. This progression provides an excellent example of some ways in which unanticipated - and often unanticipatable - applied science and {open_quotes}practical{close_quotes} devices naturally emerge from first-rate basic science. The characteristics of this process suggest that the term {open_quotes}spinoff{close_quotes} commonly used to denote it is misleading and in need of replacement.

  6. Reconstruction of eye movements during blinks

    CERN Document Server

    Baptista, M S; Kliegl, R; Engbert, R; Kurths, J

    2008-01-01

    In eye movement research in reading, the amount of data plays a crucial role for the validation of results. A methodological problem for the analysis of the eye movement in reading are blinks, when readers close their eyes. Blinking rate increases with increasing reading time, resulting in high data losses, especially for older adults or reading impaired subjects. We present a method, based on the symbolic sequence dynamics of the eye movements, that reconstructs the horizontal position of the eyes while the reader blinks. The method makes use of an observed fact that the movements of the eyes before closing or after opening contain information about the eyes movements during blinks. Test results indicate that our reconstruction method is superior to methods that use simpler interpolation approaches. In addition, analyses of the reconstructed data show no significant deviation from the usual behavior observed in readers.

  7. The Efficacy of Final Examinations: A Comparative Study of Closed-Book, Invigilated Exams and Open-Book, Open-Web Exams

    Science.gov (United States)

    Williams, Jeremy B.; Wong, Amy

    2009-01-01

    Educators have long debated the usefulness (or otherwise) of final examinations; a debate that has typically revolved around the relative merits of closed-book exams, open-book exams, take-home exams or their substitution by some other assessment format (e.g., project work). This paper adds a new dimension to the debate by considering how the…

  8. Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye.

    Science.gov (United States)

    Chowdhury, Uttio Roy; Jea, Seung-Youn; Oh, Dong-Jin; Rhee, Douglas J; Fautsch, Michael P

    2011-08-16

    PURPOSE. To characterize the role of osteopontin (OPN) in primary open-angle glaucoma (POAG) and normal eyes. METHODS. OPN quantification was performed by enzyme-linked immunosorbent assay in aqueous humor (AH) obtained from human donor eyes (POAG and normal) and surgical samples (POAG and elective cataract removal). OPN expression and localization in whole eye tissue sections and primary normal human trabecular meshwork (NTM) cells were studied by Western blot and immunohistochemistry. Latanoprost-free acid (LFA)-treated NTM cells were analyzed for OPN gene and protein expression. Intraocular pressure was measured by tonometry, and central corneal thickness was measured by optical coherence tomography in young OPN(-/-) and wild-type mice. RESULTS. OPN levels were significantly reduced in donor POAG AH compared with normal AH (0.54 ± 0.18 ng/μg [n = 8] vs. 0.77 ± 0.23 ng/μg [n = 9]; P = 0.039). A similar trend was observed in surgical AH (1.05 ± 0.31 ng/μg [n = 20] vs. 1.43 ± 0.88 ng/μg [n = 20]; P = 0.083). OPN was present in the trabecular meshwork, corneal epithelium and endothelium, iris, ciliary body, retina, vitreous humor, and optic nerve. LFA increased OPN gene expression, but minimal change in OPN protein expression was observed. No difference in intraocular pressure (17.5 ± 2.0 mm Hg [n = 56] vs. 17.3 ± 1.9 mm Hg [n = 68]) but thinner central corneal thickness (91.7 ± 3.6 μm [n = 50] vs. 99.2 ± 5.5 μm [n = 70]) was noted between OPN(-/-) and wild-type mice. CONCLUSIONS. OPN is widely distributed in the human eye and was found in lower concentrations in POAG AH. Reduction of OPN in young mice does not affect IOP.

  9. Registration and Measurement of Opening and Closing Jaw Movements and Rotational Mandibular Capacity by Using the Method of Electronic Axiography

    OpenAIRE

    Kraljević, Sonja; Pandurić, Josip; Badel, Tomislav; Dulčić, Nikša

    2003-01-01

    The aim of this study was to register and measure lower jaw movements, to analyse the measured length of opening and closing movements and to analyse the rotational mandibular capacity during the maximal opening of the mouth in the position of centric relation. Our objective was to determine the average values for each mandible and temporomandibular joint movement, as well as to determine the accuracy of electronic axiography, while diagnosing temporomandibular joint disorders....

  10. Multiple Olefin Metathesis Polymerization That Combines All Three Olefin Metathesis Transformations: Ring-Opening, Ring-Closing, and Cross Metathesis.

    Science.gov (United States)

    Lee, Ho-Keun; Bang, Ki-Taek; Hess, Andreas; Grubbs, Robert H; Choi, Tae-Lim

    2015-07-29

    We demonstrated tandem ring-opening/ring-closing metathesis (RO/RCM) polymerization of monomers containing two cyclopentene moieties and postmodification via insertion polymerization. In this system, well-defined polymers were efficiently formed by tandem cascade RO/RCM reaction pathway. Furthermore, these polymers could be transformed to new A,B-alternating copolymers via a sequential cross metathesis reaction with a diacrylate. Additionally, we demonstrated the concept of multiple olefin metathesis polymerization in which the dicyclopentene and diacrylate monomers underwent all three olefin metathesis transformations (ring-opening, ring-closing, and cross metathesis) in one shot to produce A,B-alternating copolymer.

  11. What is the importance of open habitat in a predominantly closed forest area to the dung beetle (Coleoptera, Scarabaeinae assemblage?

    Directory of Open Access Journals (Sweden)

    Fábio C. Costa

    2013-09-01

    Full Text Available What is the importance of open habitat in a predominantly closed forest to the dung beetle assemblage? The Atlantic Forest in Brazil is one of the most highly disturbed ecosystems and is mainly represented by fragmented areas. However, in places where human disturbances have ceased, certain areas are showing a natural regeneration pattern. The aim of the present study was to determine how the dung beetle assemblage responds to distinct habitat structures in a fragment of Atlantic Forest. For such, open and closed forest areas were sampled in a fragment of the Atlantic Forest in the northeastern region of Brazil. Pitfall traps baited with excrement and carrion were used to collect the beetles. A total of 7,267 individuals belonging to 35 species were captured. Canthon chalybaeus and C. mutabilis were restricted to open areas. Nearly 90% of the individuals of C. aff. simulans and Deltochilum aff. irroratum were identified in these areas. A higher percentage (> 50% of Canthon staigi, Dichotomius aff. depressicolis and D. aff. sericeus occurred in closed areas. Abundance differed between areas, with higher values in closed areas. Richness was not influenced by the habitat structure. NMDS ordination exhibited the segregation of areas and ANOSIM confirmed that this variable explained the assemblage of dung beetle species. The findings of the present study validate that open areas are associated to more restrictive conditions, limiting a higher abundance of dung beetle. Although situated near preserved fragments, the studied open areas increase the heterogeneity of the general landscape.

  12. A systematic review comparing open-book and closed-book examinations: Evaluating effects on development of critical thinking skills.

    Science.gov (United States)

    Johanns, Beth; Dinkens, Amber; Moore, Jill

    2017-08-19

    The advantages of using traditional closed-book examinations are closely compared to the advantages of using open-book examinations for the development of critical thinking skills in nursing students. The use of critical thinking skills is vital among nurses to assess patient needs and modify standard approaches to individualize care for better patient outcomes. The following areas are compared and contrasted for both closed-book and open-book examinations: examination preparation, rote memorization versus active learning, intellectual engagement, simulation of working environment, higher order thinking skills, anxiety reduction and student satisfaction. During investigation of closed-book examinations and open-book examinations, the use of collaborative testing was unveiled. Collaborative testing combines areas from both closed-book and open-book examinations. Based on the systematic review of literature, the recommendation is to use a mixed method of examination types throughout the course of the nursing program. Each type of examination helps develop different skill sets in the nursing student. Copyright © 2017 Elsevier Ltd. All rights reserved.

  13. Comparison of open and closed suction on safety, efficacy and nursing time in a paediatric intensive care unit.

    Science.gov (United States)

    Evans, Janine; Syddall, Sophie; Butt, Warwick; Kinney, Sharon

    2014-05-01

    Endotracheal suctioning (ETS) is one of the most common procedures performed in the paediatric intensive care. The two methods of endotracheal suctioning used are known as open and closed suction, but neither method has been shown to be the superior suction method in the Paediatric Intensive Care Unit (PICU). The primary purpose was to compare open and closed suction methods from a physiological, safety and staff resource perspective. All paediatric intensive care patients with an endotracheal tube were included. Between June and September 2011 alternative months were nominated as open or closed suction months. Data were prospectively collected including suction events, staff involved, time taken, use of saline, and change from pre-suction baseline in heart rate (HR), mean arterial pressure (MAP) and oxygen saturation (SpO2). Blocked or dislodged ETTs were recorded as adverse events. Closed suction was performed more often per day (7.2 vs 6.0, psuction (5 vs 3, psuction group (18% vs 40%). Open suction demonstrated a greater reduction in SpO2 and nearly three times the incidence of increases in HR and MAP compared to closed suction. Reductions in MAP or HR were comparable across the two methods. In conclusion, CS could be performed with less staffing time and number of nurses, less physiological disturbances to our patients and no significant increases in adverse events. Copyright © 2014. Published by Elsevier Ltd.

  14. A comparison of the circadian rhythm of intraocular pressure in primary phronic angle closure glaucoma, primary open angle glaucoma and normal eyes

    Directory of Open Access Journals (Sweden)

    Sihota Ramanjit

    2005-01-01

    Full Text Available Purpose: To evaluate the circadian rhythm of intraocular pressure (IOP in primary chronic angle closure glaucoma (PCACG, primary open angle glaucoma (POAG, and normal eyes. Methods: Cross-sectional study of newly diagnosed patients of POAG (60 eyes, PCACG following laser iridotomy (75 eyes, and age and sex matched normal controls (75 eyes. All subjects underwent applanation tonometry at 7 a.m., 10 a.m., 1 p.m., 4 p.m., 7 p.m., and 10 p.m. by a masked observer. Circadian rhythms were classified based upon the timing and presence of peak pressure. Results: Age and gender in all three groups were comparable. Diurnal IOP fluctuations were significantly higher in PCACG (7.69 + 3.03 mmHg and POAG (8.31 + 2.58 mmHg groups compared to normal controls (4.83 + 2.46 mmHg. PCACG eyes and controls had similarly timed circadian rhythms, with PCACG eyes having a consistently higher IOP. At 7 and 10 a.m., IOP peaked more often in POAG eyes compared to PCACG eyes. A plateau type of circadian rhythm was most common in normal eyes. The timing of peak IOP could be significantly correlated with the type of primary glaucoma examined. Conclusion: Afternoon peaks were more common in postiridotomy PCACG eyes, similar to the rhythm in normal eyes. Morning peaks were more frequent in POAG eyes. Diurnal fluctuation > 6 mmHg, associated with an IOP of 21 mmHg or more was never seen in a normal eye.

  15. Open-book tests to complement assessment-programmes : Analysis of open and closed-book tests

    NARCIS (Netherlands)

    Heijne-Penninga, M.; Kuks, J. B. M.; Schonrock-Adema, J.; Snijders, T. A. B.; Cohen-Schotanus, J.

    Today's health sciences educational programmes have to deal with a growing and changing amount of knowledge. It is becoming increasingly important for students to be able to use and manage knowledge. We suggest incorporating open-book tests in assessment programmes to meet these changes. This view

  16. Clinical experience and incidence of ventilator-associated pneumonia using closed versus open suction-system.

    Science.gov (United States)

    Åkerman, Eva; Larsson, Catharina; Ersson, Anders

    2014-01-01

    Studies have shown a decreasing ventilator-associated pneumonia (VAP) incidence after prophylactic interventions bundles. The use of closed suction systems (CSS) has been suggested beneficial as a prophylactic measure. To investigate the effects of a CSS on VAP incidence, suction circuit contamination and adverse events (AEs) compared to an open suction system (OSS) approach in a general mixed intensive care unit (ICU). Adult patients on mechanical ventilation were consecutively included. Data were collected during four 1-month periods where CSS and OSS were used on an alternating basis. Airway cultures were obtained at intubation, after 72 h and every Monday. After changing CSS and at extubation, the catheter tip was cultured. AEs and desaturation events during suction were monitored. Descriptive analysis and differences between the groups were analysed using comparative methods. No differences in airway colonization at admission between the groups were detected (Table 2). The CSS group had a higher Simplified Acute Physiology Score (SAPS) III and also a non-significant increase in VAP incidence. Positive cultures were obtained in 50% of all the retrieved CSS catheters. There was no inter-patient contamination in either group. Six AEs versus one (CSS/OSS) related to tube-occlusion and secretion clogging was seen. Desaturations at suctioning were rare in both groups. No beneficial effects were seen on VAP incidence or inter-patient contamination compared to OSS. A high frequency of circuit contamination in the CSS group paralleled with experienced secretions clearance problems seem unfavourable and in concordance with previous studies. © 2013 The Authors. Nursing in Critical Care © 2013 British Association of Critical Care Nurses.

  17. Closing the access gap for health innovations: an open licensing proposal for universities

    Directory of Open Access Journals (Sweden)

    Rajkumar Rahul

    2007-02-01

    Full Text Available Abstract Background This article centers around a proposal outlining how research universities could leverage their intellectual property to help close the access gap for health innovations in poor countries. A recent deal between Emory University, Gilead Sciences, and Royalty Pharma is used as an example to illustrate how 'equitable access licensing' could be put into practice. Discussion While the crisis of access to medicines in poor countries has multiple determinants, intellectual property protection leading to high prices is well-established as one critical element of the access gap. Given the current international political climate, systemic, government-driven reform of intellectual property protection seems unlikely in the near term. Therefore, we propose that public sector institutions, universities chief among them, adopt a modest intervention – an Equitable Access License (EAL – that works within existing trade-law and drug-development paradigms in order to proactively circumvent both national and international obstacles to generic medicine production. Our proposal has three key features: (1 it is prospective in scope, (2 it facilitates unfettered generic competition in poor countries, and (3 it centers around universities and their role in the biomedical research enterprise. Two characteristics make universities ideal agents of the type of open licensing proposal described. First, universities, because they are upstream in the development pipeline, are likely to hold rights to the key components of a wide variety of end products. Second, universities acting collectively have a strong negotiating position with respect to other players in the biomedical research arena. Finally, counterarguments are anticipated and addressed and conclusions are drawn based on how application of the Equitable Access License would have changed the effects of the licensing deal between Emory and Gilead.

  18. Open Source Subtitle Editor Software Study for Section 508 Close Caption Applications

    Science.gov (United States)

    Murphy, F. Brandon

    2013-01-01

    This paper will focus on a specific item within the NASA Electronic Information Accessibility Policy - Multimedia Presentation shall have synchronized caption; thus making information accessible to a person with hearing impairment. This synchronized caption will assist a person with hearing or cognitive disability to access the same information as everyone else. This paper focuses on the research and implementation for CC (subtitle option) support to video multimedia. The goal of this research is identify the best available open-source (free) software to achieve synchronized captions requirement and achieve savings, while meeting the security requirement for Government information integrity and assurance. CC and subtitling are processes that display text within a video to provide additional or interpretive information for those whom may need it or those whom chose it. Closed captions typically show the transcription of the audio portion of a program (video) as it occurs (either verbatim or in its edited form), sometimes including non-speech elements (such as sound effects). The transcript can be provided by a third party source or can be extracted word for word from the video. This feature can be made available for videos in two forms: either Soft-Coded or Hard-Coded. Soft-Coded is the more optional version of CC, where you can chose to turn them on if you want, or you can turn them off. Most of the time, when using the Soft-Coded option, the transcript is also provided to the view along-side the video. This option is subject to compromise, whereas the transcript is merely a text file that can be changed by anyone who has access to it. With this option the integrity of the CC is at the mercy of the user. Hard-Coded CC is a more permanent form of CC. A Hard-Coded CC transcript is embedded within a video, without the option of removal.

  19. A microwave inverse Cerenkov accelerator ({open_quotes}MICA{close_quotes})

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, T.B.; Marshall, T.C. [Columbia Univ., New York, NY (United States)

    1995-12-31

    By {open_quotes}inverting{close_quotes} the stimulated Cerenkov effect to stimulated Cerenkov absorption, it is possible to build an electron accelerator device driven by high power microwaves that propagate in a slow-wave TM mode (axial E-field). An experiment now running at Brookhaven uses a powerful C02 laser and a 50MeV electron beam moving in a gas-loaded cell. Our approach is to use the 15MW available at 2.865GHz from a SLAC klystron to accelerate an electron beam provided from an rf gun ({approximately}6MeV, few psec pulses) to energy {approximately}20MeV. The use of microwaves permits a well defined group of electrons to be accelerated in a narrow window of phase. The waveguide is a cylinder, radius = 1.59cm, which contains an annular tube of alumina ({epsilon} = 9.4) having a hole about 1cm diameter, we show this will slow the waves to 0.9943c and permit electrons to be accelerated by a co-propagating field. This results in a relatively compact structure that has the advantage of a smooth-bore design and no need of magnetic focussing. We have solved for the wave dispersion in the structure, found the fields, and then used the Lorentz force equations to obtain the motion of a group of electrons distributed in radius and along the axis. We find the radial forces are focussing. Electrons in a well-defined filament (r < 0.5mm) remain collimated and do not strike the dielectric. Techniques for improving the dielectric breakdown of the surface should permit axial fields in the range of 100-200 kV/cm.

  20. PREDICTING PROGNOSTIC VALUE OF OCULAR TRAUMA SCORE (OTS IN AN OPEN GLOBE INJURY IN TERTIARY EYE CARE HOSPITAL

    Directory of Open Access Journals (Sweden)

    Rahul

    2015-10-01

    Full Text Available AIM : To evaluate the prognostic value of OTS in open globe injuries. MATERIAL METHOD : Retrospective analysis of 77 eyes with open globe injuries was done from 01/07/2013 to 31/12/2014. Patients were assigned raw score sum based on initial V/A, and ocular findings then classified into 5 categories for predicting final visual outcome based on ocular Trauma score (OTS. RESULT : We estimated final V/A in 77 cases of open globe injuries (64.93% had raw sc ore between 65.91 (category 3, 4 Six months after the injury, 42.85% patients of categories 1 (raw score 0 - 44 achieved V/A of PL/HM as compared to 17% in OTS study. 16 patients with raw compared to OTS study. We reported comparable visual outcome with OT S study except in category 1 & 2. CONCLUSION: OTS score is valuable in triage, patient counseling and decision making for the management of ocular trauma. We recommend that OTS should be used routinely for open globe injuries as it is a simple guide

  1. EyeDroid: An Open Source Mobile Gaze Tracker on Android for Eyewear Computers

    DEFF Research Database (Denmark)

    Jalaliniya, Shahram; Mardanbeigi, Diako; Sintos, Ioannis

    2015-01-01

    In this paper we report on development and evaluation of a video-based mobile gaze tracker for eyewear computers. Unlike most of the previous work, our system performs all its processing workload on an Android device and sends the coordinates of the gaze point to an eyewear device through wireless...... connection. We propose a lightweight software architecture for Android to increase the efficiency of image processing needed for eye tracking. The evaluation of the system indicated an accuracy of 1:06 and a battery lifetime of approximate 4.5 hours....

  2. Internet-delivered eye movement desensitization and reprocessing (iEMDR): an open trial

    OpenAIRE

    Jay Spence; Nickolai Titov; Luke Johnston; Dear, Blake F.; Bethany Wootton; Matthew Terides; Judy Zou

    2013-01-01

    Recent research indicates internet-delivered cognitive behavioural therapy (iCBT) can reduce symptoms of post traumatic stress disorder (PTSD). This study examined the efficacy of an internet-delivered treatment protocol that combined iCBT and internet-delivered eye movement desensitization and reprocessing (iEMDR), in an uncontrolled trial. Eleven of the 15 participants completed post-treatment questionnaires. Large effect sizes were found from pre-treatment to 3-month follow-up ( d = 1.03 –...

  3. New performance data for {open_quotes}Emery 3002{close_quotes} and {open_quotes}Emery 3004,{close_quotes} two Army-approved safe materials to replace DOP in mask and filter testing

    Energy Technology Data Exchange (ETDEWEB)

    Carlon, H.R.; Guelta, M.A. [Army Edgewood Research, Development and Engineering Center, Aberdeen Proving Ground, MD (United States)

    1995-02-01

    At the 22nd Conference in Denver, we reported that the U.S. Army Surgeon General (SGJ) had approved our developmental material {open_quotes}Emery 3004{close_quotes} as a safe replacement for the suspected carcinogen DOP (dioctyl phthalate) in mask and filter testing throughout the Army. Subsequently the SG approved a second, less viscous material, {open_quotes}Emery 3002,{close_quotes} for similar applications. We have measured the viscosities and surface tensions of these liquids over a wide range of temperatures, and have initiated liquid breakup studies through Laskin and two-fluid nozzles. New measurements have been carried out with both liquids, e.g. using the ATI, Inc., TDA-4A cold generator to disperse aerosols for which droplet size distributions were measured using the TSI, Inc., Differential Mobility Particle Sizer (DMPS). Among the findings were that Emery 3004 performs much like DOP in the TDA-4A, with some possible advantages, while Emery 3002 in the TDA-4A produces mean droplet diameters about one-half those of Emery 3004 or DOP. This suggests that Emery 3002 could yield more rigorous filter tests with a smaller consumption of material. New laboratory results will be summarized. Sources of the {open_quotes}Emery{close_quotes} materials will be discussed since the production facility formerly operated by Emery is now run by the Ethyl Corporation and the source products are now known as {open_quotes}Ethylflo 192{close_quotes} (Emery 3002) and{open_quotes}Ethylflo 194{close_quotes} (Emery 3004).

  4. Influences of deep learning, need for cognition and preparation time on open- and closed-book test performance

    NARCIS (Netherlands)

    Heijne-Penninga, Marjolein; Kuks, Jan B. M.; Hofman, W. H. Adriaan; Cohen-Schotanus, Janke

    2010-01-01

    Objectives The ability to master discipline-specific knowledge is one of the competencies medical students must acquire. In this context, 'mastering' means being able to recall and apply knowledge. A way to assess this competency is to use both open- and closed-book tests. Student performance on bot

  5. Exploring the Relationship between Experienced Students' Preference for Open- and Closed-Book Examinations, Approaches to Learning and Achievement

    Science.gov (United States)

    Karagiannopoulou, Evangelia; Milienos, Fotios S.

    2013-01-01

    The relationship between university students' approaches to learning and preference for the open- and closed-book examinations was investigated for 144 Greek undergraduate (56 third- and 88 fourth-year) students attending a Philosophy, Education and Psychology Department. The approaches were explored by the Approaches and Study Skills Inventory…

  6. Influences of deep learning, need for cognition and preparation time on open- and closed-book test performance

    NARCIS (Netherlands)

    Heijne-Penninga, Marjolein; Kuks, Jan B. M.; Hofman, W. H. Adriaan; Cohen-Schotanus, Janke

    Objectives The ability to master discipline-specific knowledge is one of the competencies medical students must acquire. In this context, 'mastering' means being able to recall and apply knowledge. A way to assess this competency is to use both open- and closed-book tests. Student performance on

  7. Phase transfer reagent promoted tandem ring-opening and ring-closing reactions of unique 3-(1-alkynyl) chromones.

    Science.gov (United States)

    Liu, Yang; Jin, Shiyu; Huang, Liping; Hu, Youhong

    2015-05-01

    A phase transfer reagent promoted tandem ring-opening and ring-closing reaction of 3-(1-alkynyl) chromones has been developed. This process remarkably generates functionalized 3-acyl-2-substituted chromones. Interestingly, when 3-(hepta-1,6-diyn-1-yl)chromone derivatives are applied, a novel tetracyclic chromone scaffold can be obtained by a further intramolecular 4 + 2 cyclization.

  8. Accuracy and initial stability of open- and closed-wedge high tibial osteotomy: a cadaveric RSA study.

    NARCIS (Netherlands)

    Gaasbeek, R.D.A.; Welsing, R.T.C.; Verdonschot, N.J.J.; Rijnberg, W.J.; Loon, C.J.M. van; Kampen, A. van

    2005-01-01

    We analyzed the difference in angle-correction accuracy and initial stability between open-wedge (OWO) and closed-wedge tibial valgus osteotomy (CWO). Five fresh-frozen pairs of human cadaver lower limbs were used; their bone mineral density (BMD) was measured with DEXA and a planned 7 degrees valgu

  9. THE CRYSTAL-STRUCTURE OF THE OPEN AND THE CLOSED CONFORMATION OF THE FLEXIBLE LOOP OF TRYPANOSOMAL TRIOSEPHOSPHATE ISOMERASE

    NARCIS (Netherlands)

    WIERENGA, RK; NOBLE, MEM; POSTMA, JPM; GROENDIJK, H; KALK, KH; HOL, WGJ; OPPERDOES, FR

    1991-01-01

    Triosephosphate isomerase has an important loop near the active site which can exist in a "closed" and in an "open" conformation. Here we describe the structural properties of this "flexible" loop observed in two different structures of trypanosomal triosephosphate isomerase. Trypanosomal

  10. Modified closing-opening wedge osteotomy for the treatment of sagittal malalignment in thoracolumbar fractures malunion.

    Science.gov (United States)

    Bourghli, Anouar; Boissière, Louis; Vital, Jean-Marc; Bourghli, Mohamed Aiman; Almusrea, Khaled; Khoury, Ghassan; Obeid, Ibrahim

    2015-12-01

    Many techniques have been described for the surgical treatment of rigid posttraumatic thoracolumbar kyphosis, but none is well adapted to the modified shape of the wedged vertebra. The study aimed to describe the modified closing-opening wedge osteotomy (MCOWO), a new osteotomy technique that adapts to the triangular shape of the wedged apical vertebra of the deformity. A retrospective assessment of the degree of correction before and after the MCOWO was carried out. Ten patients presenting rigid posttraumatic thoracolumbar kyphosis were enrolled in this study. We used preoperative and postoperative whole spine radiographs to assess the sagittal plane parameters, and computed tomography scan for measurement of the vertebral segment height at the osteotomy level, spinal cord length, aorta length, and fusion rate. Ten patients underwent the MCOWO at T12 or L1. The procedure involves removing the postero-superior triangular corner of the wedged vertebra and transforming it to a shape similar to a trapezoid. The patients' mean age was 36.6±7.5 years, the mean time between the fracture and the surgery was 12.2±5.6 months, and the mean follow-up was 30.6±5 months. In all patients, statistically significant improvement was observed in the sagittal plane after surgery. The thoracolumbar angle improved from 52±6° preoperatively to 7.1±5.7° at the last follow-up. Mean osteotomy angle was 38.1±2.6°, mean spinal cord shortening was 1.2±0.2 cm, and mean aorta lengthening was 2.3±0.4 cm. All the patients showed complete fusion at 2 years, and none required revision surgery. Two patients presented a temporary unilateral weakness that recovered completely within 3 months after the surgery. The MCOWO is an interesting procedure for patients with posttraumatic thoracolumbar kyphosis. The modified osteotomy is adapted to the modified shape of the compressed vertebra. Spinal cord shortening and aorta lengthening were well tolerated in all patients. Copyright © 2015

  11. Molecular Dynamics Simulation on the Conformational Transition of the Mad2 Protein from the Open to the Closed State

    Directory of Open Access Journals (Sweden)

    Chaoqun Li

    2014-03-01

    Full Text Available The Mad2 protein, with two distinct conformations of open- and closed-states, is a key player in the spindle checkpoint. The closed Mad2 state is more active than the open one. We carried out conventional and targeted molecular dynamics simulations for the two stable Mad2 states and their conformational transition to address the dynamical transition mechanism from the open to the closed state. The intermediate structure in the transition process shows exposure of the β6 strand and an increase of space around the binding sites of β6 strand due to the unfolding of the β7/8 sheet and movement of the β6/4/5 sheet close to the αC helix. Therefore, Mad2 binding to the Cdc20 protein in the spindle checkpoint is made possible. The interconversion between these two states might facilitate the functional activity of the Mad2 protein. Motion correlation analysis revealed the allosteric network between the β1 strand and β7/8 sheet via communication of the β5-αC loop and the β6/4/5 sheet in this transition process.

  12. Eyes only? Perceiving eye contact is neither sufficient nor necessary for attentional capture by face direction.

    Science.gov (United States)

    Böckler, Anne; van der Wel, Robrecht P R D; Welsh, Timothy N

    2015-09-01

    Direct eye contact and motion onset both constitute powerful cues that capture attention. Recent research suggests that (social) gaze and (non-social) motion onset influence information processing in parallel, even when combined as sudden onset direct gaze cues (i.e., faces suddenly establishing eye contact). The present study investigated the role of eye visibility for attention capture by these sudden onset face cues. To this end, face direction was manipulated (away or towards onlooker) while faces had closed eyes (eliminating visibility of eyes, Experiment 1), wore sunglasses (eliminating visible eyes, but allowing for the expectation of eyes to be open, Experiment 2), and were inverted with visible eyes (disrupting the integration of eyes and faces, Experiment 3). Participants classified targets appearing on one of four faces. Initially, two faces were oriented towards participants and two faces were oriented away from participants. Simultaneous to target presentation, one averted face became directed and one directed face became averted. Attention capture by face direction (i.e., facilitation for faces directed towards participants) was absent when eyes were closed, but present when faces wore sunglasses. Sudden onset direct faces can, hence, induce attentional capture, even when lacking eye cues. Inverted faces, by contrast, did not elicit attentional capture. Thus, when eyes cannot be integrated into a holistic face representation they are not sufficient to capture attention. Overall, the results suggest that visibility of eyes is neither necessary nor sufficient for the sudden direct face effect.

  13. Medicare Benefits and Your Eyes

    Science.gov (United States)

    ... Subscribe to eNews Close Donate Medicare Benefits & Your Eyes Eye Health is Important! As you age, your risk ... that you need. Ask about eye exams! Routine Eye Exams Medicare does not generally cover the costs ...

  14. Beyond the Boundaries of Open, Closed and Pirate Archives: Lessons from a Hybrid Approach

    CERN Document Server

    Tsiavos, Prodromos

    2011-01-01

    The creation of open archives i.e. archives where access is regulated by open licensing models (content, source, data), should be seen as part of a broader socio-economic phenomenon that finds legal expression in specific organizational and technical formats.This paper examines the origins and main characteristics of the open archives phenomenon. We investigate the extent to which different models of production of economic or social value can be expressed in different forms of licensing in the context of open archives. Through this process, we assess the extent to which the digital archive is moving towards providing access that is deeper (meaning, that offers more access rights) and wider (in the sense that most of the information given is in open content licensing) or face a gradual stratification and polarization of the content. Such stratification entails the emergence of two types of content: content to which access is extremely limited and content to which access remains completely open. This differenti...

  15. Selection for litter size in pigs. II. Efficiency of closed and open selection lines*

    Directory of Open Access Journals (Sweden)

    Ollivier Louis

    2001-09-01

    Full Text Available Abstract A selection experiment on litter size in the pig was carried on for seventeen generations in an Inra experimental herd. The founder population was made up of 10 males and 120 females from the Large White breed. Selection was first performed for ten generations in a closed line, compared to a control line derived from the same founder population. Selection was carried on within sire family on the total number of piglets born in the first two litters of the dam (TB1 + TB2. After ten generations, the selection criterion became dam TB1 only. The control line was then discontinued and a panel of frozen semen from the 11th generation boars was created for later comparisons. The selected line was opened to gilt daughters of hyperprolific boars and sows, at a rate of 1/8 per generation, and the same selection procedure was applied irrespective of the origin of the gilt. During the whole experiment, the number of ova shed (OS and the number of live embryos (LE at 30 days in the 3rd pregnancy were recorded. These two parts of the experiment were analysed using REML estimation of genetic parameters and a BLUP-Animal Model in order to estimate the responses to selection. Significant heritabilities for TB1, TB2, OS and LE were obtained, i.e. 0.10, 0.05, 0.43 and 0.19, respectively. Significant common environment variances and covariances were estimated for nearly all traits. Significantly positive BLUP responses per generation were observed from G0 to G17 for TB1 (+0.086, TB2 (+0.078, OS (+0.197 and LE (+0.157. However, the responses were 3- to 4-fold higher in the G12–G17 interval compared to G0–G11, and they were also in fair agreement with previous estimates based on standard least-squares procedures, using the control line and the control frozen semen panel. Since G11, the selection intensity was increased by nearly 80 p. cent compared to the previous generations, and the proportion of hyperprolific ancestry increased up to 65 p. cent in the

  16. Modeling chemical and aerosol processes in the transition from closed to open cells during VOCALS-REx

    Directory of Open Access Journals (Sweden)

    J. Kazil

    2011-08-01

    Full Text Available Chemical and aerosol processes in the transition from closed- to open-cell circulation in the remote, cloudy marine boundary layer are explored. It has previously been shown that precipitation can initiate a transition from the closed- to the open-cellular state, but that the boundary layer cannot maintain this open-cell state without a resupply of cloud condensation nuclei (CCN. Potential sources of CCN include wind-driven production of sea salt from the ocean, nucleation from the gas phase, and entrainment from the free troposphere. In order to investigate CCN sources in the marine boundary layer and their role in supplying new particles, we have coupled in detail chemical, aerosol, and cloud processes in the WRF/Chem model, and added state-of-the-art representations of sea salt emissions and aerosol nucleation. We conduct numerical simulations of the marine boundary layer in the transition from a closed- to an open-cell state. Results are compared with observations in the Southeast Pacific boundary layer during the VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx. The transition from the closed- to the open-cell state generates conditions that are conducive to nucleation by forming a cloud-scavenged, ultra-clean layer below the inversion base. Open cell updrafts loft dimethyl sulfide from the ocean surface into the ultra-clean layer, where it is oxidized during daytime to SO2 and subsequently to H2SO4. Low H2SO4 condensation sink values in the ultra-clean layer allow H2SO4 to rise to concentrations at which aerosol nucleation produces new aerosol in significant numbers. The existence of the ultra-clean layer is confirmed by observations. We find that the observed DMS flux from the ocean in the VOCALS-REx region can support a nucleation source of aerosol in open cells that exceeds sea salt emissions in terms of the number of particles produced

  17. Examination of the conjunctival microbiota after 8 hours of eye closure.

    Science.gov (United States)

    Ramachandran, L; Sharma, S; Sankaridurg, P R; Vajdic, C M; Chuck, J A; Holden, B A; Sweeney, D F; Rao, G N

    1995-07-01

    We investigated the effect of overnight eye closure on the levels and types of microbiota in the external eye, the conjunctiva, and lid margins of 40 normal subjects during the day and immediately after eye opening following 8 hours of sleep over 3 consecutive days. Overall, clinically important levels of gram-positive bacteria were isolated from 22.1% of samples; 2.3% of samples yielded gram-negative bacterial growth. The incidence of clinically important levels of gram-positive bacteria was greater in closed-eye compared with open-eye samples. There was no significant increase in the incidence of gram-negative bacteria or fungi with eye closure. There was no difference between the open- and closed- eye samples with regard to types of microorganisms isolated. Our results suggest that eye closure may promote the growth of normal external ocular microbiota. These findings have implications for extended contact lens wear and ocular surgery.

  18. Peak exposures to main components of ash and gaseous diesel exhausts in closed and open ash loading stations at biomass-fuelled power plants.

    Science.gov (United States)

    Laitinen, Juha; Koponen, Hanna; Sippula, Olli; Korpijärvi, Kirsi; Jumpponen, Mika; Laitinen, Sirpa; Aatamila, Marjaleena; Tissari, Jarkko; Karhunen, Tommi; Ojanen, Kari; Jokiniemi, Jorma; Korpinen, Leena

    2017-10-01

    Fly and bottom ashes are collected at power plants to reduce the environmental effects of energy production. However, handling the ashes causes health problems for operators, maintenance workers and truck drivers at the power plants. Hence, we evaluated ash loaders' peak inhalation exposures to the chemical components of ash and diesel exhausts in open and closed ash loading stations at biomass-fuelled combined heat and power plants. We also carried out chemical and morphological analyses of the ashes to evaluate their health hazard potential in order to find practical technical measures to reduce workers' exposure. On the basis of X-ray diffraction analyses, the main respirable crystalline ash compounds were SiO2, CaSO4, CaO, Ca2Al2SiO7, NaCl and Ca3Al2O6 in the fly ashes and SiO2, KAlSi3O8, NaAlSi3O8 and Ca2Al2SiO7 in the bottom ashes. The short-term exposure levels of respirable crystalline silica, inhalable inorganic dust, Cr, Mn, Ni and nitric oxide exceeded their Finnish eight hours occupational exposure limit values in the closed ash loading station. According to our observations, more attention should be paid to the ash-moistening process, the use of tank trucks instead of open cassette flatbed trucks, and the sealing of the loading line from the silo to the truck which would prevent spreading the ash into the air. The idling time of diesel trucks should also be limited, and ash loading stations should be equipped with exhaust gas ventilators. If working conditions make it impossible to keep to the OEL values, workers must use respirators and protect their eyes and skin. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. The Costs of Open and Closed Access: Using the Finnish Research Output as an Example

    Directory of Open Access Journals (Sweden)

    Jyrki Ilva

    2016-04-01

    Full Text Available The Open Access movement in scientific publishing has been gathering momentum in the European Union and its member states, partly due to the policies of some of its main research funders. Already we have seen encouraging research results on the effects of openness on the dissemination of scientific outputs. As business models of Open Access publishing are still under development, the aim of our paper is to assess the statistical tools and data that the Finnish libraries currently have for comparing the costs associated with different modes of disseminating scientific publications. We will also analyse the potential costs associated with Open Access publishing models and compare them with the current cost structure of – mostly – paywalled (PW access. The discussion will include a description of current Finnish Open Access policies and their funding models. The financial analysis will be based on the statistical data found in the national Research Library Statistics database and the Finnish National Research Publications database, Juuli. We will discuss the alternatives on how best to develop statistical tools to estimate the true costs of scientific publishing.

  20. A model for open-close control of cation channels in the plasma membrane of retinal rod outer segments.

    Science.gov (United States)

    Ichikawa, K

    1989-06-01

    A model for open-close control of cation channels in the plasma membrane of retinal rod outer segments is presented. A channel is assumed to open when 3 cGMP molecules bind to it and close as soon as one of the 3 cGMP molecules is released from it. The calcium ion (divalent cation) is a modulator of the channel conductance. The channel conductance is low when Ca2+ binds to it, while it is high when it is free from Ca2+. From the above assumptions, the reaction scheme of channels with cGMP and Ca2+ is created and the fraction of channels in the open and closed states was calculated using equations for this scheme. The kinetic constants used in the model are estimated from the experimental results of many studies and from the theories. From this estimation, it was found that at the physiological concentrations of intracellular and extracellular Ca2+, almost all channels are bound with Ca2+ and are in the low conductance state. The present model accounts for the reported dose(cGMP)-response(membrane current or conductance) relationship, where the Hill coefficient decreases as the cGMP concentration increases. The dark-level cGMP concentration of 8.13 microM is estimated from the model. This is in good agreement with the reported values. Moreover, the model predicts the invariance of current noise at relatively low Ca2+ concentrations when the cGMP concentration is raised from the dark level to a saturation level. The dynamic properties (opening and closing actions) of the channels in the present model are also in good agreement with the reported observations. The burst mode opening and closing of a channel is predicted by the present model, and it was found that the number of openings in a burst is controlled by the forward and backward rate constants between a channel protein and cGMP molecules. The simulated waveform of a single channel is similar to the reported observations.

  1. [Six degree-of-freedom acquisition and analysis of jaw opening and closing with motion capture system].

    Science.gov (United States)

    Wang, Hui; Bi, Zhen-yu; Zhao, Wei-dong; Tian, Hua; Jiao, Pei-feng; Wu, Bu-ling; Zhao, Wang-hong; Liu, Yang

    2011-09-01

    To explore the six degrees of freedom of jaw opening and closing movement with motion capture and analysis system to establish a quantitative method for studying mandibular movement and a digital basis for virtual reality study of mandibular movement. In a male adult with normal dentition without temporomandibular joint disorders, 3 fluorescent markers were pasted in the upper dentition and 4 in the lower dentition. Six cameras of the motion capture system were arranged in a semi-circular fashion. The subject sat in front of the camera at an 80-cm distance with the Frankfort plane kept parallel to the horizontal plane. The degree-of-freedom (3 linear displacement and 3 angular displacement) of jaw opening and closing movement was obtained by collecting the marker motion. Six degrees of freedom of jaw opening and closing were obtained using the motion capture system. The maximum linear displacements of X, Y and Z axes were 5.888 089 cm, 0.782 269 cm, and 0.138 931 cm, and the minimum linear displacements were -3.649 83 cm, -35.961 2 cm, -5.818 63 cm, respectively. The maximum angular displacements of X, Y and Z axes were 0.760 088°, 2.803 753°, and 0.786 493°, with the minimum angular displacements of -2.526 18°, -0.625 94°, and -25.429 8°, respectively. Variations of linear displacements during jaw opening and closing occurred mainly in the Y axis, and those of angular displacement occurred mainly in the Z axis. The six degree-of-freedom of mandibular movement can be accurately obtained with the motion capture system to allow quantitative examination of the mandibular movement.

  2. Comparison of Dimensional Accuracy between Open-Tray and Closed-Tray Implant Impression Technique in 15° Angled Implants

    OpenAIRE

    Balouch F.; Jalalian E; Nikkheslat M.; Ghavamian R.; Toopchi Sh.; Jallalian F.; Jalalian S.

    2013-01-01

    Statement of Problem: Various impression techniques have different effects on the accuracy of final cast dimensions. Meanwhile; there are some controversies about the best technique. Purpose: This study was performed to compare two kinds of implant impression methods (open tray and closed tray) on 15 degree angled implants. Materials and Method: In this experimental study, a steel model with 8 cm in diameter and 3 cm in height were produced with 3 holes devised inside to stabilize 3 implants....

  3. Generalized Ψ;ρ-closed sets and generalized &Psiρ-open sets in double fuzzy topological spaces

    Science.gov (United States)

    Mohammed, Fatimah. M.; Noorani, M. S. M.; Ghareeb, A.

    2014-06-01

    The aim of this paper is to use the notion of Ψ-operations in double fuzzy topological spaces to study the concept of (r,s)-fuzzy generalized Ψρ-closed sets and (r,s)-fuzzy generalized Ψρ-open sets, some characterizations and properties of these concepts are given. Moreover, we discussed the relationship between these sets in double fuzzy topological spaces.

  4. Comparing the Effect of Open and Closed Kinetic Chain Exercises in Patients Suffering From Patellofemoral Pain Syndrome

    Directory of Open Access Journals (Sweden)

    Zahra Firoozkoohi Moghadam

    2016-11-01

    Full Text Available Introduction: Patellofemoral pain syndrome is one of the most prevalent problems in physically active people. The syndrome is a multifactorial disorder with different therapeutic approaches. Conservative treatment of the syndrome has been a crucial matter in different studies. Quadriceps muscle strengthening exercise is a recommended approach which is performed in forms of open and closed kinetic chain exercises. This study was designed to compare the efficacy of these exercises on this syndrome. Methods: Totally 30 women suffering from the syndrome aged 30-40 were randomly allocated into three groups: open, and closed kinetic chain exercises, and control group, as groups A, B, and C, respectively. Groups A and B participated in 28 sessions of exercises in a period of four weeks and group C did not do any exercise in this period. Before and after the period, pain and function of the participants were assessed using visual analog scale (VAS and Kujala patellofemoral scale, respectively. Data were analyzed using independent t test, dependent t test, and univariate variance analysis, while significance of data was determined at P < 0.05. Results: The study indicated that open kinetic chain exercises (group A for 4 weeks brought significant changes in relieving the pain along with improving the function (P = 0.001. Likewise, it was revealed a significant pain relief as well as function improvement in group B (P = 0.001. Comparing two groups illustrated that benefits of open kinetic chain exercises outweigh closed ones (P = 0.001. Conclusion: Overall, both exercises were efficient in relieving pain as well as improving function, however open kinetic chain exercises were more contributory.

  5. Structure and optics of the eyes of the box jellyfish Chiropsella bronzie

    DEFF Research Database (Denmark)

    O’Connor, Megan; Garm, Anders Lydik; Nilsson, Dan-E.

    2009-01-01

    Cubomedusae have a total of 24 eyes of four morphologically different types. Two of these eye types are camera-type eyes (upper and lower lens-eye), while the other two eye types are simpler pigment pit eyes (pit and slit eye). Here, we give a description of the visual system of the box jellyfish...... species Chiropsella bronzie and the optics of the lens eyes in this species. One aim of this study is to distinguish between general cubozoan features and species-specific features in the layout and optics of the eyes. We find that both types of lens eyes are more severely under-focused in C. bronzie than...... those in the previously investigated species Tripedalia cystophora. In the lower lens-eye of C. bronzie, blur circles subtend 20 and 52° for closed and open pupil, respectively, effectively removing all but the coarsest structures of the image. Histology reveals that the retina of the lower lens-eye...

  6. Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m).

    LENUS (Irish Health Repository)

    McMorrow, R C N

    2012-08-01

    We present a randomised, controlled, crossover trial of the Caudwell Xtreme Everest (CXE) closed circuit breathing system vs an open circuit and ambient air control in six healthy, hypoxic volunteers at rest and exercise at Everest Base Camp, at 5300 m. Compared with control, arterial oxygen saturations were improved at rest with both circuits. There was no difference in the magnitude of this improvement as both circuits restored median (IQR [range]) saturation from 75%, (69.5-78.9 [68-80]%) to > 99.8% (p = 0.028). During exercise, the CXE closed circuit improved median (IQR [range]) saturation from a baseline of 70.8% (63.8-74.5 [57-76]%) to 98.8% (96.5-100 [95-100]%) vs the open circuit improvement to 87.5%, (84.1-88.6 [82-89]%; p = 0.028). These data demonstrate the inverse relationship between supply and demand with open circuits and suggest that ambulatory closed circuits may offer twin advantages of supplying higher inspired oxygen concentrations and\\/or economy of gas use for exercising hypoxic adults.

  7. Detecting MOV stem to stem-nut lubricant degradation by reviewing MOV {open_quotes}seating time{close_quotes}

    Energy Technology Data Exchange (ETDEWEB)

    Loweth, W.A.

    1996-12-01

    The objective is to describe a methodology, suitable for IST Programs, that obtains sufficient data to assess and trend the overall condition of AC and DC MOVs. Using existing diagnostic test equipment, recording the time from Hard Seat Contact to the Torque Switch Trip point (TST), {open_quote}Seating Time (msec){close_quotes}, can provide a means to quickly detect for signs of lubricant degradation in the interface between the stem and stem-nut for MOVs. Obtaining and trending the {open_quote}Seating Time{close_quote} parameter can be easily accomplished using the sensors which provide motor current, torque or thrust. From the initial baseline test to subsequent tests, it is the change in time between Hard Seat Contact to Torque Switch Trip point that is utilized to monitor changes in the coefficient of friction between the stem and stem-nut. While many Licensees have begun their MOV Periodic Verification Programs, obtaining the {open_quotes}Seating Time{close_quotes} during Refueling Outages and comparing the results from subsequent outages can be an input to the justification for changing the MOV baseline test frequency.

  8. The role of open and closed curing conditions on the leaching properties of fly ash-slag-based geopolymers.

    Science.gov (United States)

    Izquierdo, Maria; Querol, Xavier; Phillipart, Charles; Antenucci, Diano; Towler, Mark

    2010-04-15

    This study deals with the synthesis of geopolymers from co-fired fly ash and blast furnace slags. Geopolymer bodies were simultaneously synthesized in open and closed curing conditions in order to elucidate the role of this parameter on their resultant properties. Open curing conditions produce solid bodies characterized by high porosity, low compressive strength and exacerbated leaching of certain oxyanionic metalloids. By contrast, protected curing promotes the binder development, giving rise to higher strength and less porous systems. This imposes physical restrictions to leaching which decreases and/or retards releases of oxyanionic metalloids in comparison to open curing conditions. Fly ash-slag-based geopolymers may immobilize a number of trace pollutants such as Be, Bi, Cd, Co, Cr, Cu, Nb, Ni, Pb, REE, Sn, Th, U, Y and Zr, regardless of the curing conditions. Due to geopolymers displaying weak assimilation capacity for oxyanionic species, their successful regarding oxyanionic retention is strongly dependent on porosity and therefore on curing conditions applied.

  9. Personality traits neuroticism and openness as well as early abnormal eye conditions as predictors of the occurrence of eye problems in adulthood

    National Research Council Canada - National Science Library

    Cheng, Helen; Furnham, Adrian

    2017-01-01

    This study set out to examine the associations between psychological, biomedical and socio-demographic factors in childhood and adulthood associated with the occurrence of self-reported eye conditions in adulthood...

  10. Influence of open- and closed-book tests on medical students' learning approaches

    NARCIS (Netherlands)

    Heijne-Penninga, Marjolein; Kuks, Jan B. M.; Hofman, W. H. Adriaan; Cohen-Schotanus, Janke

    2008-01-01

    CONTEXT Two learning approaches are consistently distinguished in the literature: deep and surface learning. The deep learning approach is considered preferable. Open-book tests are expected to stimulate deep learning and to offer a possible way of handling the substantial growth in medical knowledg

  11. Open and Closed Loop Parametric System Identification in Compact Disk Players

    DEFF Research Database (Denmark)

    Vidal, Enrique Sanchez; Stoustrup, Jakob; Andersen, Palle;

    2001-01-01

    By measuring the current through the coil of the actuators in the optical pick-up in a compact disk player, open loop parametric system identification can be performed. The parameters are identified by minimizing the least-squares loss function of the ARX model. The only parameter which cannot...

  12. Influence of open- and closed-book tests on medical students' learning approaches

    NARCIS (Netherlands)

    Heijne-Penninga, Marjolein; Kuks, Jan B. M.; Hofman, W. H. Adriaan; Cohen-Schotanus, Janke

    2008-01-01

    CONTEXT Two learning approaches are consistently distinguished in the literature: deep and surface learning. The deep learning approach is considered preferable. Open-book tests are expected to stimulate deep learning and to offer a possible way of handling the substantial growth in medical knowledg

  13. Influence of open- and closed-book tests on medical students' learning approaches

    NARCIS (Netherlands)

    Heijne-Penninga, Marjolein; Kuks, Jan B. M.; Hofman, W. H. Adriaan; Cohen-Schotanus, Janke

    2008-01-01

    CONTEXT Two learning approaches are consistently distinguished in the literature: deep and surface learning. The deep learning approach is considered preferable. Open-book tests are expected to stimulate deep learning and to offer a possible way of handling the substantial growth in medical

  14. 76 FR 32010 - Notice of Closed Meeting (With Open Session) of the Cultural Property Advisory Committee

    Science.gov (United States)

    2011-06-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Notice... Government of the United States of America and the Government of the Republic of Bolivia Concerning the... Ethnological Material from the Colonial and Republican Periods of Bolivia . An open session to receive...

  15. Vertebral Osteotomies in Ankylosing Spondylitis-Comparison of Outcomes Following Closing Wedge Osteotomy versus Opening Wedge Osteotomy: A Systematic Review.

    Science.gov (United States)

    Ravinsky, Robert A; Ouellet, Jean-Albert; Brodt, Erika D; Dettori, Joseph R

    2013-04-01

    Study Design Systematic review. Study Rationale To seek out and assess the best quality evidence available comparing opening wedge osteotomy (OWO) and closing wedge osteotomy (CWO) in patients with ankylosing spondylitis to determine whether their results differ with regard to several different subjective and objective outcome measures. Objective The aim of this study is to determine whether there is a difference in subjective and objective outcomes when comparing CWO and OWO in patients with ankylosing spondylitis suffering from clinically significant thoracolumbar kyphosis with respect to quality-of-life assessments, complication risks, and the amount of correction of the spine achieved at follow-up. Methods A systematic review was undertaken of articles published up to July 2012. Electronic databases and reference lists of key articles were searched to identify studies comparing effectiveness and safety outcomes between adult patients with ankylosing spondylitis who received closing wedge versus opening wedge osteotomies. Studies that included pediatric patients, polysegmental osteotomies, or revision procedures were excluded. Two independent reviewers assessed the strength of evidence using the GRADE criteria and disagreements were resolved by consensus. Results From a total of 67 possible citations, 4 retrospective cohorts (class of evidence III) met our inclusion criteria and form the basis for this report. No differences in Oswestry Disability Index, visual analog scale for pain, Scoliosis Research Society (SRS)-24 score, SRS-22 score, and patient satisfaction were reported between the closing and opening wedge groups across two studies. Regarding radiological outcomes following closing versus opening osteotomies, mean change in sagittal vertical axis ranged from 8.9 to 10.8 cm and 8.0 to 10.9 cm, respectively, across three studies; mean change in lumbar lordosis ranged from 36 to 47 degrees and 19 to 41 degrees across four studies; and mean change

  16. A phytoplankton tool for water quality assessment in semi-enclosed coastal lagoons: Open vs closed regimes

    Science.gov (United States)

    Pereira Coutinho, Maria Teresa; Brito, Ana C.; Pereira, Patrícia; Gonçalves, André S.; Moita, Maria Teresa

    2012-09-01

    The Atlantic western coast of Portugal includes several shallow coastal lagoons, such as Óbidos, Albufeira and Santo André, that are intermittently closed to the ocean by sand barriers. Their physico-chemical characteristics, as well as their residence time and tidal influence, are highly dependent on the open/closed periods and on the inter-annual raining/dry season's variability with important impacts on the phytoplankton community structure, abundance and dynamics. Furthermore, the number of coastal ecosystems with identified eutrophication symptoms is increasing worldwide due to the increasing anthropogenic pressures. Eutrophication is one of the greatest threats to water quality in coastal lagoons and a major concern for the European water quality regulators. One of the first symptoms of eutrophication is enhanced algal biomass. Thus, phytoplankton is generally one of the most important biological indicator of these processes. In this study, all available phytoplankton (chlorophyll and taxa blooms) and nutrient data from a period of more than 50 years were gathered. During the periods of closure, these lagoons have favoring conditions for phytoplankton growth, which can reach high levels of chlorophyll a (chl a, 290 μg L-1), as observed in Óbidos lagoon during the 80's. At that time, during the open periods, the highest chl a concentration registered was about one fifth lower (64 μg L-1). At present, this lagoon is artificially maintained open during almost all the time and the highest observed chl a concentration was 7 μg L-1. Comparatively, the lagoon of Albufeira still presents high phytoplankton biomass levels during the closed periods (e.g. 55 μg L-1, during winter 2004). In these semi-enclosed systems, phytoplankton blooms are recurrent and HAB species are frequently observed. Significant linear relationships were found between nutrient and chlorophyll concentration, during the open and closed periods, for the lagoon of Óbidos. This assessment

  17. Comment on {open_quote}{open_quote}Comments on the use of asymmetric monochromators for x-ray diffraction on a synchrotron source{close_quote}{close_quote} [Rev. Sci. Instrum. {bold 66}, 2174 (1995)

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez del Rio, M. [European Synchrotron Radiation Facility, B.P. 220, 38043 Grenoble-Cedex (France); Cerrina, F. [Center for X-ray Lithography, 3731 Schneider Dr., Stoughton, Wisconsin 53589 (United States)

    1996-10-01

    In the article {open_quote}{open_quote}Comments on the use of asymmetric monochromators for x-ray diffraction on a synchrotron source,{close_quote}{close_quote} by Colin Nave, Ana Gonzalez, Graham Clark, Sean McSweeney, Stewart Cummings, and Michael Hart, Rev. Sci. Instrum. {bold 66}, 2174 (1995), paragraph II, the authors{close_quote} unfamiliarity with our modeling codes leads them to claim that our approach to treat bent-asymmetrically cut crystals in ray tracing calculations is incorrect. Since SHADOW is a widely used code, it is important to correct any misunderstandings, and we give here arguments to demonstrate that our approach is perfectly valid, and the arguments used by the authors to criticize our method are based on an unwarranted conclusion extracted from one of our previous articles. We show that SHADOW, when properly run, treats the cases raised exactly. Indeed, their arguments provide a nice benchmark test for verifying the accuracy of SHADOW {copyright} {ital 1996 American Institute of Physics.}

  18. Closed windows, open doors: geopolitics and post-1949 mainland Chinese immigration to Canada.

    Science.gov (United States)

    Liu X-f; Norcliffe, G

    1996-01-01

    "Since 1949 there have been dramatic changes in the flow of migrants from Mainland China to Canada.... Even though Canada in theory opened a window for family reunification in the postwar era by removing long-standing discriminatory clauses blocking Chinese immigration, in practice cold war geopolitics led the Chinese to shut that window, blocking nearly all emigration. Changing geopolitical circumstances led China to develop an open-door policy between 1973 and 1989, leading to increasing flows of migrants to Canada. The political response in Canada to the Tiananmen Square massacre of 1989 was to allow all Chinese students and workers in Canada to stay, if they so wished.... The result was a large inflow making MCIs [mainland Chinese immigrants] the third-largest group of immigrants to Canada in the early 1990s." (EXCERPT)

  19. In-between Open and Closed - Drawing the Fine Line in Hybrid Communities

    OpenAIRE

    Mäenpää, Hanna; Kilamo, Terhi; Männistö, Tomi

    2016-01-01

    Part 1: Full Papers; International audience; Today, the community driven development model extends into a variety of new, often web based collaborations. Among these are hybrid open source development set ups in which various online tools are used to facilitate cooperation between virtual teams of commercial and voluntary stakeholders. As yet, how these relationships form and evolve is not understood extensively. This article presents a longitudinal case study of a smartphone startup that fou...

  20. Improvement of open and semi-open core wall system in tall buildings by closing of the core section in the last story

    Science.gov (United States)

    Kheyroddin, A.; Abdollahzadeh, D.; Mastali, M.

    2014-09-01

    Increasing number of tall buildings in urban population caused development of tall building structures. One of the main lateral load resistant systems is core wall system in high-rise buildings. Core wall system has two important behavioral aspects where the first aspect is related to reduce the lateral displacement by the core bending resistance and the second is governed by increasing of the torsional resistance and core warping of buildings. In this study, the effects of closed section core in the last story have been considered on the behavior of models. Regarding this, all analyses were performed by ETABS 9.2.v software (Wilson and Habibullah). Considering (a) drift and rotation of the core over height of buildings, (b) total and warping stress in the core body, (c) shear in beams due to warping stress, (d) effect of closing last story on period of models in various modes, (e) relative displacement between walls in the core system and (f) site effects in far and near field of fault by UBC97 spectra on base shear coefficient showed that the bimoment in open core is negative in the last quarter of building and it is similar to wall-frame structures. Furthermore, analytical results revealed that closed section core in the last story improves behavior of the last quarter of structure height, since closing of core section in the last story does not have significant effect on reducing base shear value in near and far field of active faults.

  1. Current Concepts in the Mandibular Condyle Fracture Management Part II: Open Reduction Versus Closed Reduction

    Directory of Open Access Journals (Sweden)

    Kang-Young Choi

    2012-07-01

    Full Text Available In the treatment of mandibular condyle fracture, conservative treatment using closedreduction or surgical treatment using open reduction can be used. Management of mandibularcondylar fractures remains a source of ongoing controversy in oral and maxillofacial trauma.For each type of condylar fracture,the treatment method must be chosen taking intoconsideration the presence of teeth, fracture height, patient’sadaptation, patient’s masticatorysystem, disturbance of occlusal function, and deviation of the mandible. In the past, closedreduction with concomitant active physical therapy conducted after intermaxillary fixationduring the recovery period had been mainly used, but in recent years, open treatment ofcondylar fractures with rigid internal fixation has become more common. The objectiveof this review was to evaluate the main variables that determine the choice of an open orclosed method for treatment of condylar fractures, identifying their indications, advantages,and disadvantages, and to appraise the current evidence regarding the effectiveness ofinterventions that are used in the management of fractures of the mandibular condyle.

  2. Open and Closed R&D Processes: Internal Versus External Knowledge

    Directory of Open Access Journals (Sweden)

    Mohammed Saleh Al.Ansari

    2013-02-01

    Full Text Available In an attempt to help keep up with the ever changing business environments, firms arecontinuously attempting to find ways to open up their organizations boundaries, enablingexternal sources to be used. Through a means of restructuring their R&D systems, firmswill face challenges when it comes to balancing their external and internal R&D activities,allowing them to profit from the amount of external knowledge that they retrieve.Throughout this paper, discussions on the influences that R&D configuration has on theperformance of firms and moderating R&D capacity will be discussed further.According to researched findings, firms that continue to rely on external R&D actionsexperience an increase in innovative performance, up to a certain point. Larger shares ofexternal R&D services will reduce a firm’s performance. Finding the perfect mediumground is something that all chemical engineering firms will need to work on, in order toincrease innovative performance, but not ruin their performance in the same respects. Thispaper will provide an increased amount of understanding in regards to the open innovationparadigm, which suggests that opportunity costs open for R&D borders is a lot higher forfirms that possess high quality technologically based knowledge stock (Elsevier B.V., 2012.

  3. Open Loop and Closed Loop Performance of Switched Reluctance Motor with Various Converter Topologies

    Directory of Open Access Journals (Sweden)

    Malligunta Kiran Kumar

    2014-07-01

    Full Text Available Switched reluctance motor (SRM is becoming popular because of its simple construction, robustness and low-maintenance. This motor is very useful for high speed applications because no windings are placed on rotor and can also be used for variable speed applications in industries. Converter is one of the important elements in SRM which plays a very crucial role. In this paper various converter topologies for 6/4 switched reluctance motor and Asymmetric bridge converter topology for 8/6 switched reluctance motor are discussed. Finally a closed loop for each converter topology is proposed. The converter topologies are simulated by using MATLAB/SIMULINK. Constant speed is achieved in closed loop control.

  4. {open_quotes}Just-in-time inventory{close_quotes} proceed with caution!

    Energy Technology Data Exchange (ETDEWEB)

    Katterhenry, W.E.

    1995-08-01

    Just when the power generation industry was stabilizing along came mega government regulations and changing economic conditions that threw a monkey wrench into the works. Although improved inventory practices have helped solve some coal problems, other still remain. The Clean Air Act has resulted in fuel switching, blending, equipment changes, and other factors, all contributing to power plant personnel grey hair. Then along came Just-In-Time inventory practices. Not only is the plant required to make all these changes to meet regulatory requirements, but reduce the quantity of fuel in inventory to unheard of low levels. Why is it so difficult to precisely account for coal in inventory? After all, inventory is a simple matter of accurately measuring the coal coming in to the plant, measuring the coal used by the plant, and conducting an accurate physical inventory to measure the remaining coal. Add to this, a major coal inventory reduction policy, when base maps are not maintained or updated and are, therefore, not likely to be accurate. Some coal may have been stored below the prevailing water table, rendering the coal unusable. Weather conditions, such as major ice storms can render much of the coal unburnable. Unless accounted for, these things reduce the perceived amount of coal in inventory. This presentation will address these issues to assist in preventing potential unscheduled plant shut down and the need to purchase unscheduled blocks of emergency power. Just-In-Time Inventory isn`t as straightforward as first meets the eye.

  5. Nonlinear Oscillations and Flow of Gas Within Closed and Open Conical Resonators

    Science.gov (United States)

    Daniels, Christopher; Finkbeiner, Joshua; Steinetz, Bruce; Li, Xiaofan; Raman, Ganesh

    2004-01-01

    A dissonant acoustic resonator with a conical shaped cavity was tested in four configurations: (A) baseline resonator with closed ends and no blockage; (B) closed resonator with internal blockage; (C) ventilated resonator with no blockage; and (D) ventilated resonator with an applied pressure differential. These tests were conducted to investigate the effects of blockage and ventilation holes on dynamic pressurization. Additionally, the investigation was to determine the ability of acoustic pressurization to impede flow through the resonator. In each of the configurations studied, the entire resonator was oscillated at the gas resonant frequency while dynamic pressure, static pressure, and temperature of the fluid were measured. In the final configuration, flow through the resonator was recorded for three oscillation conditions. Ambient condition air was used as the working fluid. The baseline results showed a marked reduction in the amplitude of the dynamic pressure waveforms over previously published studies due to the use of air instead of refrigerant as the working fluid. A change in the resonant frequency was recorded when blockages of differing geometries were used in the closed resonator, while acoustic pressure amplitudes were reduced from baseline measurements. A sharp reduction in the amplitude of the acoustic pressure waves was expected and recorded when ventilation ports were added. With elevated pressure applied to one end of the resonator, flow was reduced by oscillating the cavity at the fluid fundamental resonant frequency compared to cases without oscillation and oscillation off-resonance.

  6. Eyes wide open: reader and author responsibility in understanding the limits of peer review.

    Science.gov (United States)

    Benson, P J

    2015-10-01

    'Medical science can only flourish in a free society and dies under totalitarian repression.' (1) Peer review post-publication is relatively easy to define: when the world decides the importance of publication. Peer review pre-publication is what the scientific community frequently means when using the term 'peer review'. But what it is it? Few will agree on an exact definition; generally speaking, it refers to an independent, third party scrutiny of a manuscript by scientific experts (called peers) who advise on its suitability for publication. Peer review is expensive; although reviewers are unpaid, the cost in time is enormous and it is slow. There is often little agreement among reviewers about whether an article should be published and peer review can be a lottery. Often referred to as a quality assurance process, there are many examples of when peer review failed. Many will be aware of Woo-Suk Hwang's shocking stem cell research misconduct at Seoul National University. (2) Science famously published two breakthrough articles that were found subsequently to be completely fabricated and this happened in spite of peer review. Science is not unique in making this error. However, love it or hate it, peer review, for the present time at least, is here to stay. In this article, Philippa Benson, Managing Editor of Science Advances (the first open access journal of the American Association for the Advancement of Science), discusses the merits of peer review. Dr Benson has extensive experience in the publishing world and was Executive Director of PJB Consulting, a not-for-profit organisation supporting clients on issues related to converting to full electronic publishing workflows as well as challenges working with international authors and publishers. Her clients included the Public Library of Science journals, the American Society for Nutrition and the de Beaumont Foundation. She recently co-authored a book, What Editors Want: An Author's Guide to Scientific Journal

  7. Performance of MEMS-based visible-light adaptive optics at Lick Observatory: Closed- and open-loop control

    CERN Document Server

    Morzinski, Katie; Gavel, Donald T; Grigsby, Bryant; Dillon, Daren; Reinig, Marc; Macintosh, Bruce A

    2010-01-01

    At the University of California's Lick Observatory, we have implemented an on-sky testbed for next-generation adaptive optics (AO) technologies. The Visible-Light Laser Guidestar Experiments instrument (ViLLaGEs) includes visible-light AO, a micro-electro-mechanical-systems (MEMS) deformable mirror, and open-loop control of said MEMS on the 1-meter Nickel telescope at Mt. Hamilton. In this paper we evaluate the performance of ViLLaGEs in open- and closed-loop control, finding that both control methods give equivalent Strehl ratios of up to ~ 7% in I-band and similar rejection of temporal power. Therefore, we find that open-loop control of MEMS on-sky is as effective as closed-loop control. Furthermore, after operating the system for three years, we find MEMS technology to function well in the observatory environment. We construct an error budget for the system, accounting for 130 nm of wavefront error out of 190 nm error in the science-camera PSFs. We find that the dominant known term is internal static error...

  8. Molecular genetics of the glaucomas: Mapping of the first five {open_quotes}GLC{close_quotes} loci

    Energy Technology Data Exchange (ETDEWEB)

    Raymond, V.

    1997-02-01

    Glaucoma encompasses a complex of ocular-disease entities characterized by an optic neuropathy in which degeneration of retinal ganglion cells leads to a characteristic excavation of the head of the optic nerve. Such damage causes progressive narrowing of the visual fields and, when uncontrolled, blindness. Affected people often have ocular hypertension defined as intraocular pressures consistently >21 mm Hg in both eyes. Although ocular hypertension is no longer an obligatory diagnostic criterion for glaucoma, it is still recognized as one of the most important risk factors. A diagnosis of glaucoma is made after observation of the characteristic atrophy of the optic nerve, which is associated with typical visual field defects. In 1992, the World Health Organization estimated that, in the global population, 5.2 million people were blind as a result of glaucoma, making it the third leading cause of blindness worldwide. The most common form is adult-onset primary open-angle glaucoma, which represents {ge}50% of all cases of glaucoma. Among Caucasians, this form of the disorder affects {approximately}2% of the population >45 years old. In African Americans, prevalence of adult-onset open-angle glaucoma is three to four times higher than that observed in White Americans. More than 15 million North Americans may have some form of glaucoma, but at least half of them may not be aware of it. 43 refs., 1 tab.

  9. Study of some CVD intensifying lipids over a period of aerobic exercise in the open and closed environment

    Directory of Open Access Journals (Sweden)

    Hassan darvakh

    2016-08-01

    Full Text Available Regarding the importance of physical activity in preventing lipids disorders, this study was done with the goal of comparing one type of aerobic exercise in open and closed place on some lipids intensify CVD disorders, In this study, 45 healthy middle aged postmenopausal women were randomly divided into 3 groups of 15, tow earobic exercise and control. First, the heart rate was measured (04/15 ± 47/80, then maximal oxygen consumption (22.65 ± 1.46 and the body dimensions, including height ( 156.7 ± 6.72 weight (68.87 ± 9.22 and body mass i ndex (28.74 ± 1.78, then, cholesterol, VLDL and triglycerides values were studied in Laboratory. Time and intensity of exercise were identical for two groups. Increasing intensity of 50-70% of maximum heart rate was in 12 weeks, 30 to 90 minutes, and 5 times a week (30 minutes at 50% MHR intensity for the first week and 90 minutes of 70 percent MHR in the last week. After the training period, cholesterol, VLDL and triglycerides values were measured again and the data were analyzed with the dependent T-test, MANOVA and TUKY follow-up test. The results indicate that differences between exercise groups and control group were significant. Accordingly, the results of exercise group in open place had significant effects on reducing mean cholesterol, VLDL and triglycerides (P≤0.05. And aerobic exercise in closed place had significant effects on reducing mean cholesterol, VLDL but had not significant effects on reducing mean triglycerides and there was significant difference in VLDL values between two groups after 12 weeks (P≤0.05 as the open place group showed higher mean. As the exercise group in open place showed higher mean, this study showed that aerobic exercise, either exercise group in open place or in the exercise group in closed place causes decrease in the mean of some blood lipids like cholesterol, VLDL and triglycerides in postmenopausal women, among which exercise group in open place maby

  10. Open- and closed-circuit study of an intermediate temperature SOFC directly fueled with simulated biogas mixtures

    Science.gov (United States)

    Yentekakis, Ioannis V.

    An intermediate temperature solid oxide fuel cell (SOFC) based on a gadolinia doped ceria (GDC) solid electrolyte, a Ni(Au)-GDC cermet anode and a La 0.54Sr 0.46MnO 3 perovskite cathode was tested at 600 and 640 °C on direct feed of simulated biogas mixtures. The catalytic (open-circuit) rate of the methane dry (CO 2)-reforming reaction over Ni(Au)-GDC anode was found to be maximized at about equimolar CH 4/CO 2 feed ratio. Cell power density up to 60 mW cm -2, at a cell voltage of 445 mV and a current density of 135 mA cm -2 at 640 °C, has been obtained under closed-circuit cell operation at this optimal feed ratio. Carbon deposition was found not to downgrade cell output characteristics under closed-circuit conditions at constant external loads for ∼120 h, preceded by open- or closed-circuit operation for ∼100 additional hours.

  11. Transfer-matrix simulations of field emission from bundles of open and closed (5,5) carbon nanotubes

    Science.gov (United States)

    Mayer, A.; Miskovsky, N. M.; Cutler, P. H.; Lambin, Ph.

    2003-12-01

    We present simulations of field emission from bundles of metallic (5,5) carbon nanotubes, which are either ideally open or closed. The scattering calculations are achieved using a transfer-matrix methodology for consideration of three-dimensional aspects of both the emitting structure and the surface barrier. Band-structure effects are reproduced by using pseudopotentials and enforcing the incident states to first travel through a periodic repetition of the tubes’ basic cell before entering the region containing the fields. The bundles consist of three and six identical structures, which are placed at the corners of equilateral triangles. In all cases, the closed emitters are found to emit less current than the open ones and to be more sensitive to the electric field in their response to neighboring tubes. Due to the enhanced screening of the electric field, the bundles’ emission rates are reduced compared to those of the isolated tubes. It turns out that the rates characterizing bundle and isolated emitters are related by a simple formula, whose dependence on the electric field suggests deviations from the Fowler-Nordheim equation at high fields. Finally, the position of peaks associated with quasilocalized states on top of the closed emitters appears to be a strong indicator of the tubes’ environment.

  12. A LabVIEW model incorporating an open-loop arterial impedance and a closed-loop circulatory system.

    Science.gov (United States)

    Cole, R T; Lucas, C L; Cascio, W E; Johnson, T A

    2005-11-01

    While numerous computer models exist for the circulatory system, many are limited in scope, contain unwanted features or incorporate complex components specific to unique experimental situations. Our purpose was to develop a basic, yet multifaceted, computer model of the left heart and systemic circulation in LabVIEW having universal appeal without sacrificing crucial physiologic features. The program we developed employs Windkessel-type impedance models in several open-loop configurations and a closed-loop model coupling a lumped impedance and ventricular pressure source. The open-loop impedance models demonstrate afterload effects on arbitrary aortic pressure/flow inputs. The closed-loop model catalogs the major circulatory waveforms with changes in afterload, preload, and left heart properties. Our model provides an avenue for expanding the use of the ventricular equations through closed-loop coupling that includes a basic coronary circuit. Tested values used for the afterload components and the effects of afterload parameter changes on various waveforms are consistent with published data. We conclude that this model offers the ability to alter several circulatory factors and digitally catalog the most salient features of the pressure/flow waveforms employing a user-friendly platform. These features make the model a useful instructional tool for students as well as a simple experimental tool for cardiovascular research.

  13. When data sharing gets close to 100%: what human paleogenetics can teach the open science movement.

    Science.gov (United States)

    Anagnostou, Paolo; Capocasa, Marco; Milia, Nicola; Sanna, Emanuele; Battaggia, Cinzia; Luzi, Daniela; Destro Bisol, Giovanni

    2015-01-01

    This study analyzes data sharing regarding mitochondrial, Y chromosomal and autosomal polymorphisms in a total of 162 papers on ancient human DNA published between 1988 and 2013. The estimated sharing rate was not far from totality (97.6% ± 2.1%) and substantially higher than observed in other fields of genetic research (evolutionary, medical and forensic genetics). Both a questionnaire-based survey and the examination of Journals' editorial policies suggest that this high sharing rate cannot be simply explained by the need to comply with stakeholders requests. Most data were made available through body text, but the use of primary databases increased in coincidence with the introduction of complete mitochondrial and next-generation sequencing methods. Our study highlights three important aspects. First, our results imply that researchers' awareness of the importance of openness and transparency for scientific progress may complement stakeholders' policies in achieving very high sharing rates. Second, widespread data sharing does not necessarily coincide with a prevalent use of practices which maximize data findability, accessibility, useability and preservation. A detailed look at the different ways in which data are released can be very useful to detect failures to adopt the best sharing modalities and understand how to correct them. Third and finally, the case of human paleogenetics tells us that a widespread awareness of the importance of Open Science may be important to build reliable scientific practices even in the presence of complex experimental challenges.

  14. When Data Sharing Gets Close to 100%: What Human Paleogenetics Can Teach the Open Science Movement

    Science.gov (United States)

    Anagnostou, Paolo; Capocasa, Marco; Milia, Nicola; Sanna, Emanuele; Battaggia, Cinzia; Luzi, Daniela; Destro Bisol, Giovanni

    2015-01-01

    This study analyzes data sharing regarding mitochondrial, Y chromosomal and autosomal polymorphisms in a total of 162 papers on ancient human DNA published between 1988 and 2013. The estimated sharing rate was not far from totality (97.6% ± 2.1%) and substantially higher than observed in other fields of genetic research (evolutionary, medical and forensic genetics). Both a questionnaire-based survey and the examination of Journals’ editorial policies suggest that this high sharing rate cannot be simply explained by the need to comply with stakeholders requests. Most data were made available through body text, but the use of primary databases increased in coincidence with the introduction of complete mitochondrial and next-generation sequencing methods. Our study highlights three important aspects. First, our results imply that researchers’ awareness of the importance of openness and transparency for scientific progress may complement stakeholders’ policies in achieving very high sharing rates. Second, widespread data sharing does not necessarily coincide with a prevalent use of practices which maximize data findability, accessibility, useability and preservation. A detailed look at the different ways in which data are released can be very useful to detect failures to adopt the best sharing modalities and understand how to correct them. Third and finally, the case of human paleogenetics tells us that a widespread awareness of the importance of Open Science may be important to build reliable scientific practices even in the presence of complex experimental challenges. PMID:25799293

  15. A Discussion of the Effect of Open-Book and Closed-Book Exams on Student Achievement in an Introductory Statistics Course

    Science.gov (United States)

    Block, Robert M.

    2012-01-01

    The use of open-book tests, closed-book tests, and notecards on tests in an introductory statistics course is described in this article. A review of the literature shows that open-book assessments are universally recognized to reduce anxiety. The literature is mixed however on whether deeper learning or better preparation occurs with open-book…

  16. A novel form of {open_quotes}Tyrosinase-positive{close_quotes} oculocutaneous albinism

    Energy Technology Data Exchange (ETDEWEB)

    Fukai, K.; Lee, S.T.; Bundey, S.; Spritz, R.A. [Univ. of Wisconsin, Madison, WI (United States)]|[Birmingham Maternity Hospital, Birmingham (United Kingdom)

    1994-09-01

    Tyrosinase-positive oculocutaneous albinism (ty-pos OCA) is an autosomal recessive disorder in which the biosynthesis of melanin pigment is greatly reduced in the skin, hair, and eyes. We have shown that typical ty-pos OCA (OCA2) results from mutations of the P gene in chromosome segment 15q11-q13. We have also shown that some patients diagnosed with ty-pos OCA actually have mild forms of type I OCA (OCAI), resulting from mutations at the tyrosinase (TYR) gene at 11q14-q21. However, in about one-third of patients with ty-pos OCA we have failed to identify abnormalities of either the P or TYR genes, suggesting the possible existence of a third ty-pos OCA locus. To test this hypothesis, we investigated a large, complex, inbred Pakistani kindred. Affected individuals exhibit slight skin pigmentation with no tanning, hair that is silver at birth and darkens somewhat over time, brown irides, and reduced visual acuity with nystagmus. SSCP/heteroduplex screening and complete DNA sequence analysis of TYR gene in the proband identified no abnormalities, and analysis of a CA repeat in the TYR gene promoter showed no linkage of ty-pos OCA to this marker in this kindred. SSCP/ heteroduplex screening of the P gene also detected no abnormalities, and the (inbred) proband was heterozygous for numerous intragenic polymorphisms. These data thus exclude TYP and P. We next carried out genetic linkage analyses and homozygisty mapping using various SSLP repeats at the locations of the human homologues of the mouse brown (TYRP, 9p23), slaty (13q32), and silver (12pter-q21) genes, all of which are associated with generalized hypopigmentation in mutant animals. However, we found no evidence of linkage of any of these markers. We are currently carrying out similar analyses using markers near the putative locations of the human homologues of several other mouse hypopigmentation genes in an effort to map this novel human ty-pos OCA locus.

  17. PDCI Wide-Area Damping Control: PSLF Simulations of the 2016 Open and Closed Loop Test Plan

    Energy Technology Data Exchange (ETDEWEB)

    Wilches Bernal, Felipe [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pierre, Brian Joseph [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Elliott, Ryan Thomas [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Schoenwald, David A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Byrne, Raymond H. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Neely, Jason C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Trudnowski, Daniel J. [Montana Tech of the Univ. of Montana, Butte, MT (United States); Donnelly, Matthew K. [Montana Tech of the Univ. of Montana, Butte, MT (United States)

    2017-03-01

    To demonstrate and validate the performance of the wide-are a damping control system, the project plans to conduct closed-loop tests on the PDCI in summer/fall 2016. A test plan details the open and closed loop tests to be conducted on the P DCI using the wide-area damping control system. To ensure the appropriate level of preparedness, simulations were performed in order to predict and evaluate any possible unsafe operations before hardware experiments are attempted. This report contains the result s from these simulations using the power system dynamics software PSLF (Power System Load Flow, trademark of GE). The simulations use the WECC (Western Electricity Coordinating Council) 2016 light summer and heavy summer base cases.

  18. Final report for LDRD project {open_quotes}A new approach to protein function and structure prediction{close_quotes}

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, C.A.

    1997-03-01

    This report describes the research performed under the laboratory-Directed Research and Development (LDRD) grant {open_quotes}A new approach to protein function and structure prediction{close_quotes}, funded FY94-6. We describe the goals of the research, motivate and list our improvements to the state of the art in multiple sequence alignment and phylogeny (evolutionary tree) construction, but leave technical details to the six publications resulting from this work. At least three algorithms for phylogeny construction or tree consensus have been implemented and used by researchers outside of Sandia.

  19. Final report for LDRD project {open_quotes}A new approach to protein function and structure prediction{close_quotes}

    Energy Technology Data Exchange (ETDEWEB)

    Phillips, C.A.

    1997-03-01

    This report describes the research performed under the laboratory-Directed Research and Development (LDRD) grant {open_quotes}A new approach to protein function and structure prediction{close_quotes}, funded FY94-6. We describe the goals of the research, motivate and list our improvements to the state of the art in multiple sequence alignment and phylogeny (evolutionary tree) construction, but leave technical details to the six publications resulting from this work. At least three algorithms for phylogeny construction or tree consensus have been implemented and used by researchers outside of Sandia.

  20. Hydration Gibbs free energies of open and closed shell trivalent lanthanide and actinide cations from polarizable molecular dynamics.

    Science.gov (United States)

    Marjolin, Aude; Gourlaouen, Christophe; Clavaguéra, Carine; Ren, Pengyu Y; Piquemal, Jean-Philip; Dognon, Jean-Pierre

    2014-10-01

    The hydration free energies, structures, and dynamics of open- and closed-shell trivalent lanthanide and actinide metal cations are studied using molecular dynamics simulations (MD) based on a polarizable force field. Parameters for the metal cations are derived from an ab initio bottom-up strategy. MD simulations of six cations solvated in bulk water are subsequently performed with the AMOEBA polarizable force field. The calculated first-and second shell hydration numbers, water residence times, and free energies of hydration are consistent with experimental/theoretical values leading to a predictive modeling of f-elements compounds.

  1. Closing an open psychiatric ward: organizational change and its effect on staff uncertainty, self-efficacy, and professional functioning.

    Science.gov (United States)

    Melnikov, Semyon; Shor, Razya; Kigli-Shemesh, Ronit; Gun Usishkin, Monica; Kagan, Ilya

    2013-04-01

    Converting an open psychiatric ward to a closed one can be threatening and stressful for the medical and nursing staff involved. This study describes the effects of this change, in particular the before-after correlation among self-efficacy, professional functioning, and uncertainty. Forty-four staff participated, completing pre-/poststructured questionnaires. Uncertainty was higher before the conversion than after the conversion. Professional functioning declined after the conversion. Self-efficacy was positively correlated with pre- and postconversion functioning, but negatively correlated with postconversion uncertainty. It is important to prepare staff for this significant organizational change. Suggestions for prechange interventions are offered. © 2012 Wiley Periodicals, Inc.

  2. Comparative measurements of water vapor fluxes over a tall forest using open- and closed-path eddy covariance system

    Directory of Open Access Journals (Sweden)

    J. B. Wu

    2015-05-01

    Full Text Available Eddy covariance using infrared gas analyses has been a useful tool for gas exchange measurements between soil, vegetation and atmosphere. So far, comparisons between the open- and closed-path eddy covariance (CP system have been extensively made on CO2 flux estimations, while lacking in the comparison of water vapor flux estimations. In this study, the specific performance of water vapor flux measurements of an open-path eddy covariance (OP system was compared against a CP system over a tall temperate forest in Northeast China. The results show that the fluxes from the OP system (LEop were generally greater than the (LEcp though the two systems shared one sonic anemometer. The tube delay of closed-path analyser depended on relative humidity, and the fixed median time lag contributed to a significant underestimation of (LEcp between the forest and atmosphere, while slight systematic overestimation was also found for covariance maximization method with single broad time lag search window. After the optimized time lag compensation was made, the average difference between the 30 min (LEop and (LEcp was generally within 6%. Integrated over the annual cycle, the CP system yielded a 5.1% underestimation of forest evapotranspiration as compared to the OP system measurements (493 vs. 469 mm yr−1. This study indicates the importance to estimate the sampling tube delay accurately for water vapor flux calculations with closed-path analysers, and it also suggests that when discuss the energy balance closure problem in flux sites with closed-path eddy covariance systems, it has to be aware that some of the imbalance is possibly caused by the systematic underestimation of water vapor fluxes.

  3. Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition

    Science.gov (United States)

    Fang, Jian; Cheng, Jingdong; Wang, Jiaolong; Zhang, Qiao; Liu, Mengjie; Gong, Rui; Wang, Ping; Zhang, Xiaodan; Feng, Yangyang; Lan, Wenxian; Gong, Zhou; Tang, Chun; Wong, Jiemin; Yang, Huirong; Cao, Chunyang; Xu, Yanhui

    2016-04-01

    UHRF1 is an important epigenetic regulator for maintenance DNA methylation. UHRF1 recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone H3K9 (H3K9me3), but the regulatory mechanism remains unknown. Here we show that UHRF1 adopts a closed conformation, in which a C-terminal region (Spacer) binds to the tandem Tudor domain (TTD) and inhibits H3K9me3 recognition, whereas the SET-and-RING-associated (SRA) domain binds to the plant homeodomain (PHD) and inhibits H3R2 recognition. Hm-DNA impairs the intramolecular interactions and promotes H3K9me3 recognition by TTD-PHD. The Spacer also facilitates UHRF1-DNMT1 interaction and enhances hm-DNA-binding affinity of the SRA. When TTD-PHD binds to H3K9me3, SRA-Spacer may exist in a dynamic equilibrium: either recognizes hm-DNA or recruits DNMT1 to chromatin. Our study reveals the mechanism for regulation of H3K9me3 and hm-DNA recognition by URHF1.

  4. Kinetically blocked stable heptazethrene and octazethrene: Closed-shell or open-shell in the ground state?

    KAUST Repository

    Li, Yuan

    2012-09-12

    Polycyclic aromatic hydrocarbons with an open-shell singlet biradical ground state are of fundamental interest and have potential applications in materials science. However, the inherent high reactivity makes their synthesis and characterization very challenging. In this work, a convenient synthetic route was developed to synthesize two kinetically blocked heptazethrene (HZ-TIPS) and octazethrene (OZ-TIPS) compounds with good stability. Their ground-state electronic structures were systematically investigated by a combination of different experimental methods, including steady-state and transient absorption spectroscopy, variable temperature NMR, electron spin resonance (ESR), superconducting quantum interfering device (SQUID), FT Raman, and X-ray crystallographic analysis, assisted by unrestricted symmetry-broken density functional theory (DFT) calculations. All these demonstrated that the heptazethrene derivative HZ-TIPS has a closed-shell ground state while its octazethrene analogue OZ-TIPS with a smaller energy gap exists as an open-shell singlet biradical with a large measured biradical character (y = 0.56). Large two-photon absorption (TPA) cross sections (σ(2)) were determined for HZ-TIPS (σ(2)max = 920 GM at 1250 nm) and OZ-TIPS (σ(2)max = 1200 GM at 1250 nm). In addition, HZ-TIPS and OZ-TIPS show a closely stacked 1D polymer chain in single crystals. © 2012 American Chemical Society.

  5. The {open_quotes}Command and Control{close_quotes} philosophy of the Communist party of China

    Energy Technology Data Exchange (ETDEWEB)

    Kominiak, G.J.; Eisenberger, J.C.; Menaul, K.L. [and others

    1996-01-01

    China`s central political authorities have constructed a system which is designed to enable them to exert their personal influence and control over each level of every organization in the country -- both civil and military. The Communist Party of China (CPC) is represented at all levels of each and every organization, including the People`s Liberation Army (PLA). These Party entities are intended to both provide oversight and to ensure that Party policies, directives and orders are obeyed. This penchant for political control, which may have its roots in China`s imperial past, appears to have been reinforced by the early developmental path chosen by the Party`s leadership. Current attempts aimed at maintaining political control of its resources, especially the military, are embodied in the formal system of {open_quotes}Political Work.{close_quotes} In the PLA, this system of political control results in the involvement of political organs in day-to-day military matters to an extent unheard of in the West. Further work is needed in order to understand, more fully, both the system of {open_quotes}Political Work{close_quotes} and its contributions to the overall military (and civil) command and control philosophic of the Communist Party of China.

  6. {open_quotes}Optical guiding{close_quotes} limits on extraction efficiencies of single-pass, tapered wiggler amplifiers

    Energy Technology Data Exchange (ETDEWEB)

    Fawley, W.M. [Lawrence Berkeley Lab., CA (United States)

    1995-12-31

    Single-pass, tapered wiggler amplifiers have an attractive feature of being able, in theory at least, of extracting a large portion of the electron beam energy into light. In circumstances where an optical FEL`s wiggler length is significantly longer than the Rayleigh length Z{sub R} corresponding to the electron beam radius, diffraction losses must be controlled via the phenomenon of {open_quotes}optical guiding{close_quotes}. Since the strength of the guiding depends upon the effective refractive index {eta}{sub r} exceeding one, and since ({eta}{sub r}-1) is inversely proportional to the optical electric field, there is a natural {open_quotes}limiting{close_quotes} mechanism to the on-axis field strength and thus the rate at which energy may be extracted from the electron beam. In particular, the extraction efficiency for a prebunched beam asymptotically grows linearly with z rather than quadratically. We present analytical and numerical simulation results concerning this behavior and discuss its applicability to various FEL designs including oscillator/amplifier-radiator configurations.

  7. With eyes wide open

    DEFF Research Database (Denmark)

    Frølunde, Lisbeth; Pedersen, Chistina Hee

    2013-01-01

    The paper was presented in the panel “Tending the tensions in co-creation: A critical, reflexive approach to co-creative methods” at the 32nd IHSCR. This paper highlights different forms of tension involved in facilitating creative processes and argues that tension is a necessity for change...

  8. Eyes Wide Open

    Science.gov (United States)

    Bodemer, Brett; Brown, Karen; Crowther, Jennifer

    2009-01-01

    The Future Voices in Public Services column is a forum for students in graduate library and information science programs to discuss key issues they see in academic library public services, to envision what they feel librarians in public service have to offer to academia, to tell us of their visions for the profession, or to tell us of research…

  9. Development of a new multiple sampling trawl with autonomous opening/closing net control system for sampling juvenile pelagic fish

    Science.gov (United States)

    Oozeki, Yoshioki; Hu, Fuxiang; Tomatsu, Chiaki; Kubota, Hiroshi

    2012-03-01

    A new multiple layer sampling trawl with an autonomous net opening/closing control system was developed to sample pelagic juvenile fish quantitatively. The new trawl system, based on the Matsuda-Oozeki-Hu Trawl (MOHT), has a rigid-frame 3.3 m high and 2.35 m wide and five nets of 11.0 m length with a rectangular mouth of 2.22 m×1.81 m (4 m2 mouth area; large-scale prototype). A cambered V-shape depressor is hung below the frame and two bridles are attached at the midpoint of the side frames. A net-release controller is used, which not only controls the net release mechanism but also records the net depth, temperature and flow rate during net towing. The controller sends stored command signals to the net release mechanism as depth settings and/or time settings and does not require any commands from the surface through a conducting cable or by acoustic signals. Two other models were constructed before the construction of the large-scale prototype, which are a small-scale prototype (2 m2 mouth area) for testing the net release mechanism and a 1/4-scale model of the large-scale prototype for flume tank tests. Flume tank tests with the 1/4-scale model showed that the frame leaned forward at a tilt angle from 5 to 15 degrees at towing speeds from 0.8 to 1.4 m s-1. Opened nets closed smoothly and sequentially nets were completely opened when the trigger was released by the command. Net depth rarely changed even during changes in towing speed. Sea trials both by the small-scale and the large-scale prototype demonstrated the same towing characteristics expected from the flume tank tests. The newly developed multiple layer opening/closing MOHT (MOC-MOHT) is considered to be suitable for quantitative layer sampling of juvenile fish.

  10. Neonatal facial movements in the first minutes of life--eye opening and tongue thrust: an observational study.

    Science.gov (United States)

    Hentschel, Juliane; Ruff, Ruth; Juette, Frauke; von Gontard, Alexander; Gortner, Ludwig

    2007-11-01

    Infants born by caesarean section (CS) near or at term were observed to display spontaneous facial movements in their first minutes. We hypothesized that those are reproducible. Up to now, nothing was known about the significance, frequency, and determinants of such facial activity. Repetitive eye opening (EO) and tongue thrust (TT) actions were documented during 1 to 5 minutes, 5 to 10 minutes, and 1 to 15 minutes in 102 infants. In addition, 32 infants were recorded on video from minute 2 to minute 10. Infant- and maternal- influencing factors were noted and videos analyzed using Interact (Version 7.1, Mangold International, Arnstorf, Germany). According to our results, 99 of 102 newborns (gestational age, 33 to 42 weeks) performed EO or TT during the first 15 minutes. Preterm and infants with lower Apgar scores and infants born under general anesthesia showed less EO. Infants of smoking mothers, newborns admitted to special care, and infants with lower umbilical artery pH had significantly fewer TT episodes. Within a "normal" population of newborns of > 37 weeks at delivery (n = 57), 97% showed EO and 95% showed TT. In the filmed 32 newborns, infants began EO at 2:40 and TT at 2:34 minutes of life on average. Crying had no influence, but suctioning/intervention reduced EO frequency. In conclusion, EO and TT are occurring regularly during neonatal adaptation. TT seems to be an inborn automatic behavior; numerous occurrences of EO argue for neurological well-being. Both facial actions may initiate maternal-infant attachment.

  11. Sertraline and rapid eye movement sleep without atonia: an 8-week, open-label study of depressed patients.

    Science.gov (United States)

    Zhang, Bin; Hao, Yanli; Jia, Fujun; Tang, Yi; Li, Xueli; Liu, Wuhan; Arnulf, Isabelle

    2013-12-02

    Previous studies have reported that selective serotonin reuptake inhibitors (SSRIs) may induce or exacerbate rapid eye movement (REM) sleep without atonia (RSWA) and increase the risk of developing REM sleep behavior disorder (RBD). However, most of these studies are retrospective and cross-sectional and employed small sample sizes and a mixture of SSRIs. In this 8-week open-label trial of sertraline in depressed patients (n = 31), depressed patients were administered 50mg sertraline at 8 am on the 1st day and subsequently titrated up to a maximum of 200mg/day. All patients underwent repeated video-polysomnography (vPSG) (baseline, 1st day, 14th day, 28th day, and 56th day). Both tonic (submental) and phasic (submental and anterior tibialis) RSWA events were visually counted. Tonic RSWA increased from 3.2 ± 1.8% at baseline to 5.1 ± 2.3% on the 1st day and 10.4 ± 2.7% on the 14th day; after that, measurements were stable until the 56th day. A similar profile was observed for phasic RSWA. The increases in tonic RSWA (r = 0.56, P = 0.004) and phasic RSWA (submental: r = -0.51, P = 0.02; anterior tibialis: r = 0.41, P = 0.04) were correlated with the degree of the prolonging of REM latency. All of RSWAs were not correlated with patients' demographic and clinical characteristics. Sertraline may induce or exacerbate RSWA. In contrast to idiopathic RBD, sertraline-related RSWA had the specific characteristics of being correlated with the degree of the prolonging of REM latency and no predominance of male sex and elder age, suggesting different pathophysiological mechanisms. The antidepressant-related RSWA should be a potential public health problem in the depressed patients.

  12. Seeing the soil through the net: an eye-opener on the soil map of the Flemish region (Belgium)

    Science.gov (United States)

    Dondeyne, Stefaan; Vanierschot, Laura; Langohr, Roger; Van Ranst, Eric; Deckers, Jozef; Oorts, Katrien

    2017-04-01

    A systematic soil survey of Belgium was conducted from 1948 to 1991. Field surveys were done at the detailed scale of 1:5000 with the final maps published at a 1:20,000 scale. The legend of these detailed soil maps (scale 1:20,000) has been converted to the 3rd edition of the international soil classification system 'World Reference Base for Soil Resources' (WRB). Over the last years, the government of the Flemish region made great efforts to make these maps, along with other environmental data, available to the general audience through the internet. The soil maps are widely used and consulted by researchers, teachers, land-use planners, environmental consultancy agencies and archaeologists. The maps can be downloaded and consulted in the viewer 'Visual Soil Explorer' ('Bodemverkenner'). To increase the legibility of the maps, we assembled a collection of photographs from soil profiles representing 923 soil types and 413 photos of related landscape settings. By clicking on a specific location in the 'Visual Soil Explorer', pictures of the corresponding soil type and landscape appear in a pop-up window, with a brief explanation about the soil properties. The collection of photographs of soil profiles cover almost 80% of the total area of the Flemish region, and include the 100 most common soil types. Our own teaching experience shows that these information layers are particular valuable for teaching soil geography and earth sciences in general. Overall, such visual information layers should contribute to a better interpretation of the soil maps and legacy soil data by serving as an eye-opener on the soil map to the wider community.

  13. Closed hyperthermic intraperitoneal chemotherapy with open abdomen: a novel technique to reduce exposure of the surgical team to chemotherapy drugs

    Science.gov (United States)

    Benoit, Laurent; Cheynel, Nicolas; Ortega-Deballon, Pablo; Giacomo, Giovanni Di; Chauffert, Bruno; Rat, Patrick

    2008-01-01

    Exposure of the surgical team to toxic drugs during hyperthermic intraperitoneal chemotherapy (HIPEC) remains a matter of great concern. In closed-abdomen HIPEC operating room staffs are not exposed to drugs, but the distribution of the heated liquid within the abdomen is not optimal. In open-abdomen HIPEC, the opposite is true. Even though the open-abdomen method is potentially more effective, it has not become a standard procedure because of the risk of exposure of members of the team to drugs. We present a new technique (closed HIPEC with open abdomen) which ensures protection against potentially contaminating exposure to liquids, vapours and aerosols, and allows permanent access to the whole abdominal cavity. Its principle is to extend the abdominal surgical wound upwards with a sort of “glove-box”. The cutaneous edges of the laparotomy are stapled to a latex «wall expander». The expander is draped over a special L-section metal frame placed above the abdomen. A transparent cover containing a « hand-access » port like those used in laparoscopic surgery is fixed inside the frame. In 10 patients, this device proved to be hermetic both for liquids and vapours. Intra-abdominal temperature was maintained between 42 and 43°C during most of the procedure. The whole abdominal cavity was accessible to the surgeon allowing optimal exposure of all peritoneal surfaces. This technique allows optimal HIPEC while limiting the potential toxic effects for the surgical, medical and paramedical teams. PMID:17929098

  14. Downlink Training Techniques for FDD Massive MIMO Systems: Open-Loop and Closed-Loop Training With Memory

    Science.gov (United States)

    Choi, Junil; Love, David J.; Bidigare, Patrick

    2014-10-01

    The concept of deploying a large number of antennas at the base station, often called massive multiple-input multiple-output (MIMO), has drawn considerable interest because of its potential ability to revolutionize current wireless communication systems. Most literature on massive MIMO systems assumes time division duplexing (TDD), although frequency division duplexing (FDD) dominates current cellular systems. Due to the large number of transmit antennas at the base station, currently standardized approaches would require a large percentage of the precious downlink and uplink resources in FDD massive MIMO be used for training signal transmissions and channel state information (CSI) feedback. To reduce the overhead of the downlink training phase, we propose practical open-loop and closed-loop training frameworks in this paper. We assume the base station and the user share a common set of training signals in advance. In open-loop training, the base station transmits training signals in a round-robin manner, and the user successively estimates the current channel using long-term channel statistics such as temporal and spatial correlations and previous channel estimates. In closed-loop training, the user feeds back the best training signal to be sent in the future based on channel prediction and the previously received training signals. With a small amount of feedback from the user to the base station, closed-loop training offers better performance in the data communication phase, especially when the signal-to-noise ratio is low, the number of transmit antennas is large, or prior channel estimates are not accurate at the beginning of the communication setup, all of which would be mostly beneficial for massive MIMO systems.

  15. Open or close the gate – stomata action under the control of phytohormones in drought stress conditions

    Directory of Open Access Journals (Sweden)

    Agata eDaszkowska-Golec

    2013-05-01

    Full Text Available Two highly specialized cells, the guard cells that surround the stomatal pore, are able to integrate environmental and endogenous signals in order to control the stomatal aperture and thereby the gas exchange. The uptake of CO2 is associated with a loss of water by leaves. Control of the size of the stomatal aperture optimizes the efficiency of water use through dynamic changes in the turgor of the guard cells. The opening and closing of stomata is regulated by the integration of environmental signals and endogenous hormonal stimuli. The various different factors to which the guard cells respond translates into the complexity of the network of signaling pathways that control stomatal movements. The perception of an abiotic stress triggers the activation of signal transduction cascades that interact with or are activated by phytohormones. Among these, abscisic acid (ABA, is the best-known stress hormone that closes the stomata, although other phytohormones, such as jasmonic acid, brassinosteroids, cytokinins or ethylene are also involved in the stomatal response to stresses. As a part of the drought response, ABA may interact with jasmonic acid and nitric oxide in order to stimulate stomatal closure. In addition, the regulation of gene expression in response to ABA involves genes that are related to ethylene, cytokinins and auxin signaling. In this paper, recent findings on phytohormone crosstalk, changes in signaling pathways including the expression of specific genes and their impact on modulating stress response through the closing or opening of stomata, together with the highlights of gaps that need to be elucidated in the signaling network of stomatal regulation, are reviewed.

  16. Prognostic factors for open globe injuries and correlation of ocular trauma score at a tertiary referral eye care centre in Singapore.

    Science.gov (United States)

    Agrawal, Rupesh; Wei, Ho Sue; Teoh, Stephen

    2013-09-01

    To evaluate the factors influencing final vision outcome after surgical repair of open globe injuries and to correlate the Ocular trauma score. Retrospective case analysis of patients with open globe injuries at a tertiary referral eye care centre in Singapore was performed. Pre-operative factors affecting final vision outcome in patients with open globe injury and correlation of ocular trauma score in our study with international ocular trauma scoring system was performed. Case records of 172 eyes with open globe injury were analyzed. Mean age was 36. 67 years. Mean follow up was 12.26 m. Males were pre-dominantly affected. Initial visual acuity was ≥ 20/40, 20/50 < 20/200, 20/200- CF, HM- PL and NLP in 24 (14%), 39 (22.7%), 16 (9.3%), 66 (38.4%) and 27 (15.7%) eyes respectively. Final visual acuity was ≤ 20/40, 20/50 < 20/200, 20/200- 1/200, HM- PL and NLP in 76 (44.2%), 28 (16.3%), 11 (6.4%), 30 (17.4%) and 27 (15.7%) eyes respectively. Ocular trauma score in our study correlates with international ocular trauma scoring system. The present study showed pre-operative variables such as mode of injury, pre-operative visual acuity, traumatic cataract, hyphaema, relative afferent papillary defect, vitreous lossand vitreous hemorrhage to be adversely affecting the final vision outcome. Our study showed a good synchrony with international ocular trauma score (OTS) and based on this study we were able to validate application of OTS in Singapore population. Recognizing these factors can help the surgeon in evidence based counseling.

  17. Prognostic factors for open globe injuries and correlation of Ocular Trauma Score at a tertiary referral eye care centre in Singapore

    Directory of Open Access Journals (Sweden)

    Rupesh Agrawal

    2013-01-01

    Full Text Available Objective: To evaluate the factors influencing final vision outcome after surgical repair of open globe injuries and to correlate the Ocular trauma score. Materials and Methods: Retrospective case analysis of patients with open globe injuries at a tertiary referral eye care centre in Singapore was performed. Pre-operative factors affecting final vision outcome in patients with open globe injury and correlation of ocular trauma score in our study with international ocular trauma scoring system was performed. Results: Case records of 172 eyes with open globe injury were analyzed. Mean age was 36. 67 years. Mean follow up was 12.26 m. Males were pre-dominantly affected. Initial visual acuity was ≥20/40, 20/50 < 20/200, 20/200- CF, HM- PL and NLP in 24 (14%, 39 (22.7%, 16 (9.3%, 66 (38.4% and 27 (15.7% eyes respectively. Final visual acuity was ≤20/40, 20/50 < 20/200, 20/200- 1/200, HM- PL and NLP in 76 (44.2%, 28 (16.3%, 11 (6.4%, 30 (17.4% and 27 (15.7% eyes respectively. Ocular trauma score in our study correlates with international ocular trauma scoring system. Conclusion: The present study showed pre-operative variables such as mode of injury, pre-operative visual acuity, traumatic cataract, hyphaema, relative afferent papillary defect, vitreous lossand vitreous hemorrhage to be adversely affecting the final vision outcome. Our study showed a good synchrony with international ocular trauma score (OTS and based on this study we were able to validate application of OTS in Singapore population. Recognizing these factors can help the surgeon in evidence based counseling.

  18. Higher detection sensitivity of anxiolytic effects of diazepam by ledge-free open arm with opaque walled closed arm elevated plus maze in male rats.

    Science.gov (United States)

    Horii, Yasuyuki; Kawaguchi, Maiko

    2015-11-01

    The elevated plus maze (EPM) is an established method for testing animal anxiety. However, EPM apparatuses and their features can differ among laboratories, most notably in the presence/absence of ledges on the open arm and/or the transparency/opaqueness of walls on the closed arm. The combined effects of these variable arm features on EPM behavior are not yet fully understood. In the present study, we prepared four types of EPM apparatus - open arms with (0.5 cm) or without (0 cm) ledges×closed arms with transparent or opaque walls - and compared the maze-exploration behavior of male Sprague-Dawley rats. We found that the presence of open arm ledges significantly increased the incidence of open arm exploration. Furthermore, time spent in the distal segment of the open arm was shortest in the apparatus that had open arms with no ledges and opaque closed arms (No-Ledges/Opaque), and was longest in the apparatus that had open arms with ledges and transparent closed arms (Ledges/Transparent). Additionally, the No-Ledges/Opaque apparatus could detect the effect of 0.5mg/kg diazepam, an anxiolytic drug, whereas the Ledges/Transparent apparatus could not. These results indicate that arm structure (features of both open and closed arms) significantly influences maze-exploratory behavior in rats, and that No-Ledges/Opaque apparatuses have higher detection sensitivity for anxiolytic effects of diazepam than that of Ledges/Transparent apparatuses.

  19. Factors influencing the characteristics of the fish faunas in offshore, deeper waters of permanently-open, seasonally-open and normally-closed estuaries

    Science.gov (United States)

    Chuwen, Benjamin M.; Hoeksema, Steeg D.; Potter, Ian C.

    2009-02-01

    This study explored the ways in which various factors influence the species compositions, species richness and catch rates of fishes in offshore, deeper waters of the basin and river regions of five estuaries, which are located along ca 400 km of the southern coastline of Western Australia and differ markedly in their physico-chemical characteristics. Gill netting seasonally for two years at sites in the basin and saline lower reaches of the main tributary of the seasonally-open Broke, Irwin and Wilson inlets, the permanently-open Oyster Harbour and the normally-closed Wellstead Estuary yielded 22,329 fishes representing 58 species. Overall, and irrespective of estuary type, the species compositions of the basins and rivers differed markedly. This was attributable to consistently greater abundances of Mugil cephalus, and usually also of Acanthopagrus butcheri, in the rivers of each estuary and to the restriction of a range of species largely to the basins. However, the compositions in the basins of the five estuaries varied markedly, reflecting differences in the extent and duration of the opening of the estuary mouth and/or whether extensive growths of macrophytes were present. Changes in the ichthyofaunal composition of the normally-closed Wellstead Estuary between the first and second years of the study were attributable, in particular, to the movement of two mugilid species into offshore waters as they increased in size. Cyclical changes in ichthyofaunal composition were conspicuous in both regions of the estuary that underwent the most pronounced seasonal variations in environmental conditions. In each estuary, species richness was greater in the basin than river, where salinities were more variable and fell to lower levels and were thus less conducive to the immigration of most marine species. Catch rates were least in Broke Inlet, which had the lowest primary productivity, and were particularly high in Wellstead Estuary, which is highly eutrophic. The

  20. Hardware platforms for MEMS gyroscope tuning based on evolutionary computation using open-loop and closed -loop frequency response

    Science.gov (United States)

    Keymeulen, Didier; Ferguson, Michael I.; Fink, Wolfgang; Oks, Boris; Peay, Chris; Terrile, Richard; Cheng, Yen; Kim, Dennis; MacDonald, Eric; Foor, David

    2005-01-01

    We propose a tuning method for MEMS gyroscopes based on evolutionary computation to efficiently increase the sensitivity of MEMS gyroscopes through tuning. The tuning method was tested for the second generation JPL/Boeing Post-resonator MEMS gyroscope using the measurement of the frequency response of the MEMS device in open-loop operation. We also report on the development of a hardware platform for integrated tuning and closed loop operation of MEMS gyroscopes. The control of this device is implemented through a digital design on a Field Programmable Gate Array (FPGA). The hardware platform easily transitions to an embedded solution that allows for the miniaturization of the system to a single chip.

  1. Influence of the crack propagation rate in the obtaining opening and closing stress intensity factor by finite element method

    Directory of Open Access Journals (Sweden)

    Luiz Carlos H. Ricardo

    2016-03-01

    Full Text Available Crack propagation simulation began with the development of the finite element method; the analyses were conducted to obtain a basic understanding of the crack growth. Today structural and materials engineers develop structures and materials properties using this technique as criterion design. The aim of this paper is to verify the effect of different crack propagation rates in determination of crack opening and closing stress of an ASTM specimen under a standard suspension spectrum loading from FD&E SAE Keyhole Specimen Test Load Histories by finite element analysis. The crack propagation simulation was based on release nodes at the minimum loads to minimize convergence problems. To understand the crack propagation processes under variable amplitude loading, retardation effects are discussed.

  2. Simulation of open-loop plasma vertical movement response in the Damavand tokamak using closed-loop subspace system identification

    Science.gov (United States)

    Darestani Farahani, N.; Abbasi Davani, F.

    2016-02-01

    The formulation of a multi-input single-output closed-loop subspace method for system identification has been employed for the purpose of obtaining control-relevant model of the open loop response for plasma vertical movement in the Damavand tokamak. Such a model is particularly well suited for the robust controller design. The method described in this paper is a kind of worst-case identification technique, aiming to minimize the error between the identified model and the true plant. The accuracy of the estimation of the plant dynamics has been tested by different experiments. The fitness of the identified model around the defined operating point has been more than 90%, and compared to the physical-based model, it has better root mean squared error (RMSE) measure of the goodness of fitting.

  3. Practical Platform for Open and Closed Loop Speed Control of an Inverter Driven Asynchronous Machine Used for Teaching Purposes

    Directory of Open Access Journals (Sweden)

    Dan Claudiu Rus

    2014-09-01

    Full Text Available The paper presents a laboratory setup based on a SIMOVERT MASTER- DRIVES MC Inverter from SIEMENS used for open and closed loop speed control of an induction machine. The platform allows four quadrant operation of the machine using both the classical V/Hz scalar principle and field oriented vector control principle. The rectifier unit consists of a classical three phase diode bridge and two high voltage capacitors in order to obtain a voltage source behavior of the converter. In order to obtain the four quadrant operation of the drive, several methods are investigated out of which one is proposed and implemented. The theoretical aspects of V/Hz scalar principle and field oriented vector control principle are better explained using the proposed experimental platform.

  4. Preparative purification of Trichoderma reesei native and {open_quotes}core{close_quotes} cellobiohydrolase I by electrophoresis and chromatofocusing

    Energy Technology Data Exchange (ETDEWEB)

    Offord, D.A.; Lee, N.E.; Woodward, J. [Oak Ridge National Lab., TN (United States)

    1991-12-31

    The enzymes present in the cellulose complex produced by the fungus Trichoderma reesei have been the subject of considerable attention in consequence of their potential for converting cellulosic materials into glucose for further use in fermentation processes. Cellobiohydrolase I (CBH I) is the major component of crude commercial fungal cellulose preparations and catalyzes the conversion of insoluble cellulose into cellobiose. The primary structure of CBH I is known, and its tertiary structure, deduced from small-angle X-ray scattering studies, takes the shape of a tadpole with a catalytic head region known as {open_quotes}core{close_quotes} CBH I and a C-terminal cellulose-binding tail region. Removal of the tail can be accomplished with the protease papain, resulting in reduced activity towards insoluble substrates but unchanged activity towards soluble substrates.

  5. Development of the simulation system {open_quotes}IMPACT{close_quotes} for analysis of nuclear power plant severe accidents

    Energy Technology Data Exchange (ETDEWEB)

    Naitoh, Masanori; Ujita, Hiroshi; Nagumo, Hiroichi [Nuclear Power Corp. (Japan)] [and others

    1997-07-01

    The Nuclear Power Engineering Corporation (NUPEC) has initiated a long-term program to develop the simulation system {open_quotes}IMPACT{close_quotes} for analysis of hypothetical severe accidents in nuclear power plants. IMPACT employs advanced methods of physical modeling and numerical computation, and can simulate a wide spectrum of senarios ranging from normal operation to hypothetical, beyond-design-basis-accident events. Designed as a large-scale system of interconnected, hierarchical modules, IMPACT`s distinguishing features include mechanistic models based on first principles and high speed simulation on parallel processing computers. The present plan is a ten-year program starting from 1993, consisting of the initial one-year of preparatory work followed by three technical phases: Phase-1 for development of a prototype system; Phase-2 for completion of the simulation system, incorporating new achievements from basic studies; and Phase-3 for refinement through extensive verification and validation against test results and available real plant data.

  6. On B-type open-closed Landau-Ginzburg theories defined on Calabi-Yau Stein manifolds

    CERN Document Server

    Babalic, Mirela; Lazaroiu, Calin Iuliu; Tavakol, Mehdi

    2016-01-01

    We consider the bulk algebra and topological D-brane category arising from the differential model of the open-closed B-type topological Landau-Ginzburg theory defined by a pair $(X,W)$, where $X$ is a non-compact Calabi-Yau manifold and $W$ has compact critical set. When $X$ is a Stein manifold (but not restricted to be a domain of holomorphy), we extract equivalent descriptions of the bulk algebra and of the category of topological D-branes which are constructed using only the analytic space associated to $X$. In particular, we show that the D-brane category is described by projective matrix factorizations defined over the ring of holomorphic functions of $X$. We also discuss simplifications of the analytic models which arise when $X$ is holomorphically parallelizable and illustrate these analytic models in a few classes of examples.

  7. A comparison of open-loop and closed-loop adaptive calibration for pattern recognition based myoelectric control.

    Science.gov (United States)

    Jiayuan He; Dingguo Zhang; Xinjun Sheng; Xiangyang Zhu

    2015-08-01

    This study presented a closed-loop adaptive calibration (CLAC) scheme where subjects could get instantaneous feedback of their movements and alter their motions immediately to update the model parameters to enhance its ability. The real-time performance was compared between the conventional open-loop calibration (OLC) and the presented CLAC based on three metrics (motion-selection time, motion-completion time and motion-completion rate). The CLAC performed slightly better than the OLC, but the difference was not significant. This was the first study designed to investigate the effects of CLAC for pattern recognition-based myoelectric control (discrete movement). The CLAC could be potentially applied in the multiuser interface to make the adaptation of the common model to a novel user efficiently and flexibly.

  8. On the exact open-closed vertex in plane-wave light-cone string field theory

    CERN Document Server

    Lucietti, J; Sinha, A K; Lucietti, James; Schafer-Nameki, Sakura; Sinha, Aninda

    2003-01-01

    The open-closed vertex in the maximally supersymmetric type IIB plane-wave light-cone string field theory is considered and an explicit solution for the bosonic part of the vertex is derived, valid for all values of the mass parameter, \\mu. This vertex is of relevance to IIB plane-wave orientifolds, as well as IIB plane-wave strings in the presence of D-branes, and their gauge theory duals. Methods of complex analysis are used to develop a systematic procedure for obtaining the solution. This procedure is first applied to the vertex in flat space, and then extended to the plane-wave case. The plane-wave solution for the vertex requires introducing certain ``\\mu-deformed Gamma functions'', which are generalizations of the ordinary Gamma function. The behaviour of the Neumann matrices is graphically illustrated and their large-\\mu asymptotics are analysed.

  9. Dry Eye

    Science.gov (United States)

    ... Eye > Facts About Dry Eye Facts About Dry Eye This information was developed by the National Eye ... the best person to answer specific questions. Dry Eye Defined What is dry eye? Dry eye occurs ...

  10. Eye Allergies

    Science.gov (United States)

    ... Español Eye Health / Eye Health A-Z Eye Allergies Sections What Are Eye Allergies? Eye Allergy Symptoms ... allergy diagnosis Eye allergy treatment What Are Eye Allergies? Written by: David Turbert Reviewed by: Brenda Pagan- ...

  11. TFE and Spt4/5 open and close the RNA polymerase clamp during the transcription cycle.

    Science.gov (United States)

    Schulz, Sarah; Gietl, Andreas; Smollett, Katherine; Tinnefeld, Philip; Werner, Finn; Grohmann, Dina

    2016-03-29

    Transcription is an intrinsically dynamic process and requires the coordinated interplay of RNA polymerases (RNAPs) with nucleic acids and transcription factors. Classical structural biology techniques have revealed detailed snapshots of a subset of conformational states of the RNAP as they exist in crystals. A detailed view of the conformational space sampled by the RNAP and the molecular mechanisms of the basal transcription factors E (TFE) and Spt4/5 through conformational constraints has remained elusive. We monitored the conformational changes of the flexible clamp of the RNAP by combining a fluorescently labeled recombinant 12-subunit RNAP system with single-molecule FRET measurements. We measured and compared the distances across the DNA binding channel of the archaeal RNAP. Our results show that the transition of the closed to the open initiation complex, which occurs concomitant with DNA melting, is coordinated with an opening of the RNAP clamp that is stimulated by TFE. We show that the clamp in elongation complexes is modulated by the nontemplate strand and by the processivity factor Spt4/5, both of which stimulate transcription processivity. Taken together, our results reveal an intricate network of interactions within transcription complexes between RNAP, transcription factors, and nucleic acids that allosterically modulate the RNAP during the transcription cycle.

  12. Registration and measurement of opening and closing jaw movements and rotational mandibular capacity by using the method of electronic axiography.

    Science.gov (United States)

    Kraljević, Sonja; Pandurić, Josip; Badel, Tomislav; Dulcić, Niksa

    2003-01-01

    The aim of this study was to register and measure lower jaw movements, to analyse the measured length of opening and closing movements and to analyse the rotational mandibular capacity during the maximal opening of the mouth in the position of centric relation. Our objective was to determine the average values for each mandible and temporomandibular joint movement, as well as to determine the accuracy of electronic axiography, while diagnosing temporomandibular joint disorders. A statistical analysis was performed in order to evaluate whether significant differences between the length of the measured movements in asymptomatic and symptomatic subjects could be found. A symptomatic group consisted of 51 subjects with temporomandibular disorders. A control group consisted of 43 subjects without signs and symptoms of temporomandibular joint disorders. Each subject was registered by the GAMMA CADIAX system for registration of position and movement of the lower jaw, which consists of a conventional SAM axiograph, an electronic device for drawing curves by means of a computer. No significant differences were found between the groups of subjects for the measured variables. The results of the length of the mandibular and condyle movements, along with the rotational capacity of the mandible are important, in spite of unreliable indicators of temporomandibular joint function. Description analysis of a graphic recording of mandibular and TMJ movement remains an accurate evaluation method for the determination of TMJ dysfunction.

  13. Effects of organic pollution and physical stress on benthic macroinvertebrate communities from two intermittently closed and open coastal lagoons (ICOLLs)

    Science.gov (United States)

    Coelho, Susana; Pérez-Ruzafa, Angel; Gamito, Sofia

    2015-12-01

    Benthic macroinvertebrate communities and environmental conditions were studied in two intermittently closed and open coastal lakes and lagoons (ICOLLs), located in southern Algarve (Foz do Almargem e Salgados), with the purpose of evaluating the effects of organic pollution, originated mainly from wastewater discharges, and the physical stress caused by the irregular opening of the lagoons. Most of the year, lagoons were isolated from the sea, receiving the freshwater inputs from small rivers and in Salgados, also from the effluents of a wastewater plant. According to environmental and biotic conditions, Foz do Almargem presented a greater marine influence and a lower trophic state (mesotrophic) than Salgados (hypereutrophic). Benthic macroinvertebrate communities in the lagoons were distinct, just as their relations with environmental parameters. Mollusca were the most abundant macroinvertebrates in Foz do Almargem, while Insecta, Oligochaeta and Crustacea were more relevant in Salgados. Corophium multisetosum occurred exclusively in Salgados stations and, just as Chironomus sp., other Insecta and Oligochaeta, densities were positively related to total phosphorus, clay content and chlorophyll a concentration in the sediment, chlorophyll a concentration in water and with total dissolved inorganic nitrogen. Abra segmentum, Cerastoderma glaucum, Peringia ulvae and Ecrobia ventrosa occurred only in Foz do Almargem, with lower values of the above mentioned parameters. Both lagoons were dominated by deposit feeders and taxa tolerant to environmental stress, although in Salgados there was a greater occurrence of opportunistic taxa associated to pronounced unbalanced situations, due to excess organic matter enrichment.

  14. Comparison of three optimized digestion methods for rapid determination of chemical oxygen demand: Closed microwaves, open microwaves and ultrasound irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Domini, Claudia E. [Departamento de Quimica, Universidad Nacional del Sur, Av. Alem 1253, 8000 Bahia Blanca (Argentina); Hidalgo, Montserrat [Departamento de Quimica Analitica, Nutricion y Bromatologia, Universidad de Alicante, Apdo. 99, 03080 Alicante (Spain); Marken, Frank [Department of Chemistry, University of Bath, Bath BA2 7AY (United Kingdom); Canals, Antonio [Departamento de Quimica Analitica, Nutricion y Bromatologia, Universidad de Alicante, Apdo. 99, 03080 Alicante (Spain)]. E-mail: a.canals@ua.es

    2006-03-02

    In the present work, experimental design was used for the fast optimization of three kinds of sample digestion procedures with the final aim of obtaining the COD value of wastewater samples. The digestion methods evaluated were 'closed microwave-assisted' (CMWD), 'open microwave-assisted' (OMWD) and 'ultrasound-assisted' (USD). Classical digestion was used as reference method. The optimum values for the different variables studied in each method were: 90 psi pressure, 475 W power and 4 min irradiation time (CMWD); 150 deg. C temperature and 4 min irradiation time (OMWD); 90% of maximum nominal power (180 W), 0.9 s (s{sup -1}) cycles and 1 min irradiation time (USD). In all cases, interference concentration that produces a deviation of 10% in COD values is 13.4, 23.4, 21.1 and 2819 mg/L for S{sup 2-}, Fe{sup 2+}, NO{sub 2} {sup -} and Cl{sup -}, respectively. Under optimum conditions, the proposed digestion methods have been successfully applied, with the exception of pyridine, to several pure organic compounds and COD recoveries for 10 real wastewater samples were ranged between 88 and 104% of the values obtained with the classical (open reflux) method used as reference, with R.S.D. lower than 4% in most cases. Thus, the use of ultrasound energy for COD determination seems to be an interesting and promising alternative to conventional open reflux and microwave-assisted digestion methods used for the same purpose since the instrumentation is simpler, cheaper and safer and the digestion step faster than the ones used for the same purpose.

  15. Rate and time to develop first central line-associated bloodstream infections when comparing open and closed infusion containers in a Brazilian Hospital

    Directory of Open Access Journals (Sweden)

    Margarete Vilins

    Full Text Available The objective of the study was to determine the effect of switching from an open (glass or semi-rigid plastic infusion container to a closed, fully collapsible plastic infusion container (Viaflex® on rate and time to onset of central lineassociated bloodstream infections (CLABSI. An open-label, prospective cohort, active healthcare-associated infection surveillance, sequential study was conducted in three intensive care units in Brazil. The CLABSI rate using open infusion containers was compared to the rate using a closed infusion container. Probability of acquiring CLABSI was assessed over time and compared between open and closed infusion container periods; three-day intervals were examined. A total of 1125 adult ICU patients were enrolled. CLABSI rate was significantly higher during the open compared with the closed infusion container period (6.5 versus 3.2 CLABSI/1000 CL days; RR=0.49, 95%CI=0.26- 0.95, p=0.031. During the closed infusion container period, the probability of acquiring a CLABSI remained relatively constant along the time of central line use (0.8% Days 2-4 to 0.7% Days 11-13 but increased in the open infusion container period (1.5% Days 2-4 to 2.3% Days 11-13. Combined across all time intervals, the chance of a patient acquiring a CLABSI was significantly lower (55% in the closed infusion container period (Cox proportional hazard ratio 0.45, p= 0.019. CLABSIs can be reduced with the use of full barrier precautions, education, and performance feedback. Our results show that switching from an open to a closed infusion container may further reduce CLABSI rate as well as delay the onset of CLABSIs. Closed infusion containers significantly reduced CLABSI rate and the probability of acquiring CLABSI.

  16. Rate and time to develop first central line-associated bloodstream infections when comparing open and closed infusion containers in a Brazilian Hospital

    Directory of Open Access Journals (Sweden)

    Margarete Vilins

    2009-10-01

    Full Text Available The objective of the study was to determine the effect of switching from an open (glass or semi-rigid plastic infusion container to a closed, fully collapsible plastic infusion container (Viaflex® on rate and time to onset of central lineassociated bloodstream infections (CLABSI. An open-label, prospective cohort, active healthcare-associated infection surveillance, sequential study was conducted in three intensive care units in Brazil. The CLABSI rate using open infusion containers was compared to the rate using a closed infusion container. Probability of acquiring CLABSI was assessed over time and compared between open and closed infusion container periods; three-day intervals were examined. A total of 1125 adult ICU patients were enrolled. CLABSI rate was significantly higher during the open compared with the closed infusion container period (6.5 versus 3.2 CLABSI/1000 CL days; RR=0.49, 95%CI=0.26- 0.95, p=0.031. During the closed infusion container period, the probability of acquiring a CLABSI remained relatively constant along the time of central line use (0.8% Days 2-4 to 0.7% Days 11-13 but increased in the open infusion container period (1.5% Days 2-4 to 2.3% Days 11-13. Combined across all time intervals, the chance of a patient acquiring a CLABSI was significantly lower (55% in the closed infusion container period (Cox proportional hazard ratio 0.45, p= 0.019. CLABSIs can be reduced with the use of full barrier precautions, education, and performance feedback. Our results show that switching from an open to a closed infusion container may further reduce CLABSI rate as well as delay the onset of CLABSIs. Closed infusion containers significantly reduced CLABSI rate and the probability of acquiring CLABSI.

  17. Belgian experience in applying the {open_quotes}leak-before-break{close_quotes} concept to the primary loop piping

    Energy Technology Data Exchange (ETDEWEB)

    Gerard, R.; Malekian, C.; Meessen, O. [Tractebel Energy Engineering, Brussels (Belgium)

    1997-04-01

    The Leak Before Break (LBB) concept allows to eliminate from the design basis the double-ended guillotine break of the primary loop piping, provided it can be demonstrated by a fracture mechanics analysis that a through-wall flaw, of a size giving rise to a leakage still well detectable by the plant leak detection systems, remains stable even under accident conditions (including the Safe Shutdown Earthquake (SSE)). This concept was successfully applied to the primary loop piping of several Belgian Pressurized Water Reactor (PWR) units, operated by the Utility Electrabel. One of the main benefits is to permit justification of supports in the primary loop and justification of the integrity of the reactor pressure vessel and internals in case of a Loss Of Coolant Accident (LOCA) in stretch-out conditions. For two of the Belgian PWR units, the LBB approach also made it possible to reduce the number of large hydraulic snubbers installed on the primary coolant pumps. Last but not least, the LBB concept also facilitates the steam generator replacement operations, by eliminating the need for some pipe whip restraints located close to the steam generator. In addition to the U.S. regulatory requirements, the Belgian safety authorities impose additional requirements which are described in details in a separate paper. An novel aspect of the studies performed in Belgium is the way in which residual loads in the primary loop are taken into account. Such loads may result from displacements imposed to close the primary loop in a steam generator replacement operation, especially when it is performed using the {open_quote}two cuts{close_quotes} technique. The influence of such residual loads on the LBB margins is discussed in details and typical results are presented.

  18. Molecular detection of canine parvovirus in flies (Diptera) at open and closed canine facilities in the eastern United States.

    Science.gov (United States)

    Bagshaw, Clarence; Isdell, Allen E; Thiruvaiyaru, Dharma S; Brisbin, I Lehr; Sanchez, Susan

    2014-06-01

    to determine the correlation of fly CPV status (positive or negative) for each facility, facility design (open or closed), mean number of dogs present monthly and number of flies captured. Significant differences occurred between fly CPV positive vs. negative sites with regard to their CPV case numbers, fly numbers captured, and number of dogs present. At the ASL, a statistically significant relationship was found between PCR-determined fly CPV status (positive or negative) and facility design (open vs. closed). Open-facility designs were likely to have more CPV outbreaks and more likely to have flies testing positive for CPV DNA.

  19. Mass spectrometry of planetary exospheres at high relative velocity: direct comparison of open- and closed source measurements

    Science.gov (United States)

    Meyer, Stefan; Tulej, Marek; Wurz, Peter

    2016-04-01

    The exploration of habitable worlds around the gas giants in the Solar System is of major interest in upcoming planetary missions. Exactly this theme is addressed by the Jupiter Icy Moons Explorer (JUICE) mission of ESA, which will characterise Ganymede, Europa and Callisto as planetary objects and potential habitats [1], [2]. We developed a prototype of the Neutral gas and Ion Mass spectrometer (NIM) of the Particle Environment Package (PEP) for the JUICE mission intended for composition measurements of neutral gas and thermal plasma. NIM/PEP will be used to measure the chemical composition of the exospheres of the icy Jovian moons. Besides direct ion measurement, the NIM instrument is able to measure the inflowing neutral gas in two different modes: in neutral mode the gas enters directly the ion source (open source) and in thermal mode, the gas gets thermally accommodated to wall temperature by several collisions inside an equilibrium sphere before entering the ion source (closed source). We performed measurements with the prototype NIM using a neutral gas beam of 1 up to 5 km/s velocity in the neutral and thermal mode. The current trajectory of JUICE foresees a flyby velocity of 4 km/s at Europa, other flybys are in the range of 1 up to 7 km/s and velocity in Ganymede orbits is around 2 km/s. Different species are used for gas beam, such as noble gases Ne, Ar, Kr as well as molecules like H2, Methane, Ethane, Propane and more complex ones. We will present the results of these measurements with respect to fragmentation and density enhancements in the closed source mode. Furthermore, we will give a direct comparison between open and closed source mode measurements. References: [1] ESA, "JUICE assessment study report (Yellow Book)", ESA/SRE(2011)18, 2012. [2] O. Grasset, M.K. Dougherty, A. Coustenis, E.J. Bunce, C. Erd, D. Titov, M. Blanc, A. Coates, P. Drossart, L.N. Fletcher, H. Hussmann, R. Jaumann, N. Krupp, J.-P. Lebreton, O. Prieto-Ballesteros, P. Tortora, F

  20. Mass spectrometry of planetary exospheres at high relative velocity: direct comparison of open- and closed-source measurements

    Science.gov (United States)

    Meyer, Stefan; Tulej, Marek; Wurz, Peter

    2017-01-01

    The exploration of habitable environments on or inside icy moons around the gas giants in the solar system is of major interest in upcoming planetary missions. Exactly this theme is addressed by the JUpiter ICy moons Explorer (JUICE) mission of ESA, which will characterise Ganymede, Europa and Callisto as planetary objects and potential habitats. We developed a prototype of the Neutral Gas and Ion Mass spectrometer (NIM) of the Particle Environment Package (PEP) for the JUICE mission intended for composition measurements of neutral gas and thermal plasma. NIM/PEP will be used to measure the chemical composition of the exospheres of the icy Jovian moons. Besides direct ion measurement, the NIM instrument is able to measure the inflowing neutral gas in two different modes: in neutral mode, where the gas enters directly the ion source (open source), and in thermal mode, where the gas gets thermally accommodated to the wall temperature by several collisions inside an equilibrium sphere, called antechamber, before entering the ion source (closed source). We performed measurements with the prototype NIM using a neutral gas beam of 1 up to 4.5 km s-1 velocity in the neutral and thermal mode. The current trajectory of JUICE foresees a flyby velocity of 4 km s-1 at Europa; other flybys are in the range of 1 up to 7 km s-1 and orbital velocity in Ganymede orbits is around 2 km s-1. Different species are used for the gas beam, such as noble gases Ne, Ar, Kr as well as molecules like H2, methane, ethane, propane and more complex ones. The NIM prototype was successfully tested under realistic JUICE mission conditions. In addition, we find that the antechamber (closed source) behaves as expected with predictable density enhancement over the specified mass range and within the JUICE mission phase velocities. Furthermore, with the open source and the closed source we measure almost the same composition for noble gases, as well as for molecules, indicating no additional

  1. Psoriasis: an eye opener – a cross-sectional study in a Tertiary Care Hospital of South India

    Directory of Open Access Journals (Sweden)

    Hari Kishan Kumar Yadalla

    2015-01-01

    Full Text Available Introduction: Psoriasis is a multi-system chronic inflammatory skin disease targeting 2% to 3% of the general population. It is a prototype of immune dysregulation mediated by TH1 proinflammatory cytokines such as TNF-α, IFN-gamma, IL-6, and IL-12 with far reaching systemic effects. There is growing and emerging evidence that psoriasis patients have a higher prevalence of associated comorbid diseases, with severe skin disease portends a serious risk for development of these comorbidities and are found to have a higher association of extracutaneous disease manifestations. Aim: To look for eye involvement in psoriasis patients and to evaluate the risk and prognostic factors of disease association. Material and Methods: 200 Patients with psoriasis were screened for any eye involvement after few unusual case presentations with eye complications during the period from September 2013 - August 2014. Results: First case was a post cataract sudden loss of vision secondary to development of uveitis in a female patient aged 52 years, with past history of psoriasis with minimal skin lesions and no arthritis. Another 5 cases of psoriasis with eye involvement were detected during the screening employed in a series of 200 psoriasis cases. Conclusion: The present report highlights the importance of psoriasis and eye involvement, need for collaboration between dermatologists and ophthalmologists for thorough examination and evaluation prior to any surgical intervention and also further long term follow-up studies are warranted for confirmation of this causal relationship.

  2. Open mouth bone scintigraphy is better than closed mouth bone scintigraphy in the diagnosis of temporomandibular osteoarthritis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ki Seong; Song, Ho Chun; Cho, Sang Geon [Dept. of Nuclear Medicine, Chonnam National University Hospital, Gwangju (Korea, Republic of); and others

    2016-09-15

    Closed-mouth bone scintigraphy (CM scan) and closed-mouth single-photon emission computed tomography (CM SPECT) are used for conventional evaluation of osteoarthritis of the temporomandibular joint (TMJ). However, the adequacy of open-mouth bone scintigraphy (OM scan) has not yet been evaluated. Therefore, the purpose of this study was to compare the diagnostic performance of CM scan, CM SPECT, and OM scan. Thirty-six patients with suspicion of an abnormality of the TMJ and who underwent a 99mTc-HDP CM scan, CM SPECT, and an OM scan were enrolled. The scans were assessed visually for the presence of positive focal uptake in the TMJ. Osteoarthritis was defined as arthralgia plus crepitus or radiologic signs of arthrosis. Of 72 TMJs, 21 (29.2 %) were diagnosed with osteoarthritis. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 90.5 %, 49.0 %, 42.2 %, 92.6 % and 61.1 % for the CM scan, 81.0 %, 58.8 %, 44.7 %, 88.2 % and 65.3 % for CM SPECT, and 81.0 %, 82.4 %, 65.4 %, 91.3 % and 81.9 % for the OM scan, respectively. The accuracy of the OM scan was higher than that of CM SPECT and the CM scans (p = 0.004 and p < 0.001, respectively). The OM scan was more accurate than the conventional CM scan and even CM SPECT for diagnosing TMJ osteoarthritis.

  3. Eyes OpenEyes Closed” EEG/fMRI data set including dedicated “Carbon Wire Loop” motion detection channels

    Directory of Open Access Journals (Sweden)

    Johan van der Meer

    2016-06-01

    This paper also links to an EEGlab “EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis” (Delorme and Makeig, 2004 [2] plugin to perform a CWL regression approach to deal with the He pump artifact, as published in the main paper “Carbon-wire loop based artifact correction outperforms post-processing EEG/fMRI corrections-A validation of a real-time simultaneous EEG/fMRI correction method” (van der Meer et al., 2016 [3].

  4. Value of EMG analysis of mandibular elevators in open-close-clench cycle to diagnosing TMJ disturbance syndrome.

    Science.gov (United States)

    Chong-Shan, S; Hui-Yun, W

    1989-01-01

    The EMGs of the temporal and masseter muscle, in sixty patients with temporomandibular joint disturbance syndrome (TMJDS) and thirty normal controls, were recorded during rhythmical open-close-clench cycle movement and before and after occlusal splint therapy. The duration of the muscle contraction before initial tooth contact (DMC), the latent period (LP) and the silent period (SP) of the myoelectrical activity were used as indices for exploring their diagnostic value. In contrast with the controls, DMC, LP and SP lengthened in the patients. The DMC was prolonged in those patients where there were TMJ sounds, the inter-cuspated position did not coincide with the muscular contact position and there was deviated mandibular movement. An increase of the SP was related to tooth contact on the balancing side. After treatment, the DMC and SP in the patients returned to the level of the controls. It was found that the internal correction rate of Fisher's linear discriminate function established for the DMC and SP of the temporal and masseter muscles was 80.9% and 85.1% respectively. The results show that the DMC and SP of the temporal and masseter muscles have some value in diagnosing muscular dysfunction and discriminating therapeutic effectiveness.

  5. Laboratory {open_quotes}proof of principle{close_quotes} investigation for the acoustically enhanced remediation technology

    Energy Technology Data Exchange (ETDEWEB)

    Iovenitti, J.L.; Spencer, J.W. Jr.; Hill, D.G. [Weiss Associates, Emergyville, CA (United States)] [and others

    1995-10-01

    Weiss Associates is conducting a three phase program investigating the systematics of using acoustic excitation fields (AEFs) to enhance the in-situ remediation of contaminated soil and ground water under both saturated and unsaturated conditions: Phase I - Laboratory Scale Parametric Investigation; Phase II - Technology Scaling Study; and Phase III - Large Scale Field Tests. Phase I, the subject of this paper, consisted primarily of a laboratory proof of principle investigation. The field deployment and engineering viability of acoustically enhanced remediation (AER) technology was also examined. Phase II is a technology scaling study addressing the scale up between laboratory size samples on the order of inches, and the data required for field scale testing, on the order of hundreds of feet. Phase III will consist of field scale testing at an non-industrialized, non-contaminated site and at a contaminated site to validate the technology. Summarized herein are the results of the Phase I {open_quotes}proof-of-principle{close_quotes} investigation, and recommendations for Phase H. A general overview of AER technology along with the plan for the Phase I investigation was presented.

  6. In vivo argon laser vascular welding using thermal feedback: open and closed loop patency and collagen crosslinking

    Energy Technology Data Exchange (ETDEWEB)

    Small, W., LLNL

    1997-02-28

    An in vivo study of vascular welding with a fiber-delivered argon laser was conducted using a canine model. Longitudinal arteriotomies and venotomies were treated on femoral vein and artery. Laser energy was delivered to the vessel wall via a 400 {micro}m optical fiber. The surface temperature at the center of the laser spot was monitored in real time using a hollow glass optical fiber-based two-color infrared thermometer. The surface temperature was limited by either a room-temperature saline drip or direct feedback control of the laser using a mechanical shutter to alternately pass and block the laser. Acute patency was evaluated either visually (leak/no leak) or by in vivo burst pressure measurements. Biochemical assays were performed to investigate the possible laser-induced formation or destruction of enzymatically mediated covalent crosslinks between collagen molecules. Viable welds were created both with and without the use of feedback control. Tissues maintained at 50 C using feedback control had an elevated crosslink count compared to controls, while those irradiated without feedback control experienced a decrease. Differences between the volumetric heating associated with open and closed loop protocols may account for the different effects on collagen crosslinks. Covalent mechanisms may play a role in argon laser vascular fusion.

  7. Open reduction and closed reduction internal fixation in treatment of femoral neck fractures: a meta-analysis.

    Science.gov (United States)

    Wang, Weiguo; Wei, Junjie; Xu, Zhanwang; Zhuo, Wenkun; Zhang, Yuan; Rong, Hui; Cao, Xuecheng; Wang, Pingshan

    2014-05-22

    A meta-analysis was performed to assess the association between healing rate, avascular necrosis (AVN) of femoral head and two reductions-open reduction internal fixation (ORIF) and closed reduction internal fixation (CRIF) for femoral neck fracture. A literature-based search was conducted to identify all relevant studies published before September 10, 2013. The odd ratio (OR) and 95% confidence interval (CI) were used for estimating the effects of the two reduction methods. Data were independently extracted by two investigators who reached a consensus on all of the items. The heterogeneity between studies was examined by χ2-based Q statistic. Egger's regression analysis was used to evaluate publication bias. Statistical analysis was performed by Stata 10.0 software. We examined 14 publications. The results of the present meta-analysis showed that AVN of femoral head were significant associated with the two reductions (CRIF vs. ORIF, OR=1.746, 95% CI 1.159-2.628, p=0.008), while the healing rate were not (CRIF vs. ORIF, OR=0.853, 95% CI 0.573-1.270, p=0.433). The present meta-analysis indicated the risk of AVN of femoral head was significant higher after CRIF fixation compared with ORIF, but no association between the healing rate and the two reductions for femoral neck fracture.

  8. Proton exchange membrane fuel cell degradation under close to open-circuit conditions. Part I: In situ diagnosis

    Science.gov (United States)

    Wu, Jinfeng; Yuan, Xiao-Zi; Martin, Jonathan J.; Wang, Haijiang; Yang, Daijun; Qiao, Jinli; Ma, Jianxin

    Durability of polymer exchange membrane (PEM) fuel cells under a wide range of operational conditions has been generally identified as one of the top technical gaps that need to be overcome for the acceptance of this fuel cell technology as a commercially viable power source, especially for automotive and portable applications. In this study, a 1200 h lifetime test was conducted with a six-cell PEM fuel cell stack under close to open-circuit conditions. In situ measurements of the hydrogen crossover rate through the membrane, high frequency resistance and electrochemically active surface area of each single cell, in combination with cell polarization curves, were used to investigate the degradation mechanisms. Direct gas mass spectrometry of the cathode exhaust gas indicated the formation of HF, H 2O 2 and CO 2 during the durability testing. The overall cell degradation rate under this accelerated stress testing is approximately 0.128 mV h -1. The cell degradation rate for the first 800 h is much lower than that after 800 h, which may result from the dominance of different degradation mechanisms. For the first period, the degradation of fuel cell performance was mainly attributed to catalyst decay, while the subsequent dramatic degradation is likely caused by membrane failure.

  9. A Thermo-Hydro-Mechanical modeling of fracture opening and closing due heat extraction from geothermal reservoir

    Science.gov (United States)

    Nand Pandey, Sachchida; Chaudhuri, Abhijit; Kelkar, Sharad

    2015-04-01

    -water injection. The initial fracture aperture was taken 1mm. The Young's modulus of rock matrix and joint stiffness were taken as 15GPa and 15GPa/m respectively. Our results show that the contraction of rock due to cooling causes the opening of the fracture near injection well. However in some regions where temperature drop is insignificant the compressive stress develops and fracture closes. As the heat extraction continues with time, further contraction of rock causes more aperture growth between the wells. For the above-mentioned computational domain, due to cold-water (20 °C) at mass flow rate 4kg/s, the aperture in the vicinity of the injection well increases by 75%. Our simulation for joint stiffness equal to 50GPa/m, show that the magnitudes of normal tensile and compressive stresses in the fracture/joint are almost same but the aperture alteration is proportionally reduced. Since the joint stiffness is a nonlinear function of opening, it is important to include a suitable nonlinear model for joint opening/closing while simulating the fracture transmissivity alter during heat extraction.

  10. MR imaging of claustrophobic patients in an open 1.0T scanner: motion artifacts and patient acceptability compared with closed bore magnets.

    Science.gov (United States)

    Bangard, Christopher; Paszek, Jennifer; Berg, Frank; Eyl, Gesa; Kessler, Josef; Lackner, Klaus; Gossmann, Axel

    2007-10-01

    To evaluate motion artifacts and patient acceptability of MR imaging of claustrophobic patients in an open 1.0T scanner. Thirty six claustrophobic patients were enrolled prospectively, 34 of which had previous MR examinations in closed bore magnets. Anxiety and pain during MR examination in an open 1.0T scanner were evaluated by visual analogue scales and various tests. Influence of motion artifacts on image quality was evaluated by two radiologists independently using a five-point scale. Additionally, 36 non-claustrophobic patients delivered a reference value of a non-claustrophobic population for the visual analogue anxiety scale. Termination rate of MR imaging of highly claustrophobic patients decreased from 58.3% (n=21) in closed bore magnets to 8.3% (n=3) in the open scanner (pclaustrophobic patients compared with closed bore magnets. Motion artifacts did not influence image quality.

  11. A pharmacoeconomic analysis to determine the relative cost-effectiveness of bimatoprost 0.03% eye drops and brimonidine 0.2% eye drops in patients of primary open-angle glaucoma/ocular hypertension

    Directory of Open Access Journals (Sweden)

    Navreet Kaur Natt

    2014-01-01

    Full Text Available Aims: The aim was to compare efficacy and cost-effectiveness of bimatoprost 0.03% and brimonidine 0.2% in primary open-angle glaucoma (POAG/ocular hypertension (OHT. Settings and Design: Open, randomized, cross-over, comparative study. Materials and Methods: Forty patients of POAG or OHT with intraocular pressure (IOP <30 mm Hg were included in the study after a written informed consent. The patients were divided randomly into two groups of 20 patients each. Patients of group A were administered bimatoprost 0.03% eye drops once daily, and those of group B brimonidine 0.2% eye drops twice daily for a period of 4 weeks. After a washout period of 4 weeks, the patients were crossed over that is, group A was administered brimonidine 0.2% and group B bimatoprost 0.03%. Fall in IOP at 4 weeks was recorded. The daily cost of each drug was calculated by maximum retail price and the average number of drops per bottle. The cost-effectiveness was then calculated as the cost of drug/mm Hg fall in IOP. Statistics: Independent samples t-test was used to compare the efficacy of both drugs. Results: IOP lowering with bimatoprost (8.9 ± 1.598 mm Hg was significantly (P < 0.0001 higher than brimonidine (6.55 ± 1.26 mm Hg. The number of drops/ml were 33.43 ± 0.52 and 25.49 ± 0.26, respectively, for bimatoprost and brimonidine. Treatment with bimatoprost was costlier than brimonidine with daily costs/eye Rs. 4.02 ± 0.06 and 3.14 ± 0.03, yearly costs/eye Rs. 1467.46 ± 20.74 and 1147.75 ± 11.15, respectively. Bimatoprost was more cost-effective than brimonidine with the cost-effectiveness ratio (CER respectively Rs. 13.10 ± 2.61/mm Hg and Rs. 13.96 ± 2.86/mm Hg. Incremental CER Rs. 10.43/mm Hg implies lower costs/mm Hg extra IOP lowering by bimatoprost than Rs. 13.96 for brimonidine. Conclusion: In spite of being costlier, bimatoprost is more efficacious and cost-effective than brimonidine.

  12. Comparison of clinical and radiological outcomes between opening-wedge and closing-wedge high tibial osteotomy: A comprehensive meta-analysis

    Science.gov (United States)

    Wu, Lingfeng; Lin, Jun; Jin, Zhicheng; Cai, Xiaobin; Gao, Weiyang

    2017-01-01

    High tibial osteotomy (HTO) has been widely used for clinical treatment of osteoarthritis of the medial compartment of the knee, and both opening-wedge and closing-wedge HTO are the most commonly used methods. However, it remains unclear which technique has better clinical and radiological outcomes in practice. To systematically evaluate this issue, we conducted a comprehensive meta-analysis by pooling all available data for the opening-wedge HTO and closing-wedge HTO techniques from the electronic databases including PubMed, Embase, Wed of Science and Cochrane Library. A total of 22 studies encompassing 2582 cases were finally enrolled in the meta-analysis. There was no significant difference regarding surgery time, duration of hospitalization, knee pain VAS, Lysholm score and HSS knee score (clinical outcomes) between the opening-wedge and closing-wedge HTO groups (P > 0.05). However, the opening-wedge HTO group showed wider range of motion than the closing-wedge HTO group (P = 0.003). Moreover, as for Hip-Knee-Ankle angle and mean angle of correction, no significant difference was observed between the opening-wedge and closing-wedge HTO groups (P > 0.05), while the opening-wedge HTO group showed greater posterior tibial slope angle (P < 0.001) and lesser patellar height than the closing-wedge HTO group (P < 0.001). On light of the above analysis, we believe that individualized surgical approach should be introduced based on the clinical characteristics of each patient. PMID:28182736

  13. Association between open or closed reduction and avascular necrosis in developmental dysplasia of the hip: A PRISMA-compliant meta-analysis of observational studies.

    Science.gov (United States)

    Wang, Ya-Jie; Yang, Fan; Wu, Qi-Jun; Pan, Shi-Nong; Li, Lian-Yong

    2016-07-01

    The risk of avascular necrosis of the femoral head (AVN) after treatment of developmental dysplasia of the hip is associated with the method of reduction. Some authors have suggested that open reduction is a risk factor for AVN; however, this is controversial. To our knowledge, a quantitative comparison of the incidence of AVN between closed and open reduction has not been conducted. Published studies were identified by searching PubMed, EMBASE, and the Cochrane Library up to May, 2015, focusing on the incidence of AVN after closed or open reduction for developmental dysplasia of the hip in children aged data. Discrepancies were discussed and resolved by consensus. We pooled the odds ratios (ORs) and 95% confidence intervals (95%CIs) from individual studies using a random-effects model and evaluated heterogeneity and publication bias. Nine retrospective studies were included in this analysis. The pooled OR for comparing open reduction with closed reduction for all grades of AVN was 2.26 (95%CI = 1.21-4.22), with moderate heterogeneity (I = 44.7%, P = 0.107). The pooled OR for grades II to IV AVN was 2.46 (95%CI = 0.93-6.51), with high heterogeneity (I = 69.6%, P = 0.003). A significant association was also found for the further surgery between open and closed reduction, with a pooled OR of 0.30 (95%CI = 0.15-0.60) and moderate heterogeneity (I = 46.4%, P = 0.133). No evidence of publication bias or significant heterogeneity between subgroups was detected by meta-regression analyses. Findings from this meta-analysis suggest that open reduction is a risk factor for the development of AVN compared with closed treatment. Future studies are warranted to investigate how open reduction combined with pelvis and/or femoral osteotomy affects the incidence of AVN.

  14. MR imaging of claustrophobic patients in an open 1.0 T scanner: Motion artifacts and patient acceptability compared with closed bore magnets

    Energy Technology Data Exchange (ETDEWEB)

    Bangard, Christopher [Department of Radiology, University of Cologne, Kerpener Str. 62, 50924 Cologne (Germany)], E-mail: cbangard@gmx.de; Paszek, Jennifer [Department of Neurology, University of Cologne, Kerpener Str. 62, 50924 Cologne (Germany)], E-mail: jennypaszek@gmx.de; Berg, Frank [Department of Radiology, University of Cologne, Kerpener Str. 62, 50924 Cologne (Germany)], E-mail: frank.berg@uk-koeln.de; Eyl, Gesa [Department of Radiology, University of Cologne, Kerpener Str. 62, 50924 Cologne (Germany)], E-mail: gesa.eyl@gmx.de; Kessler, Josef [Department of Neurology, University of Cologne, Kerpener Str. 62, 50924 Cologne (Germany)], E-mail: kessler@nf.mpg.de; Lackner, Klaus [Department of Radiology, University of Cologne, Kerpener Str. 62, 50924 Cologne (Germany)], E-mail: klaus.lackner@uk-koeln.de; Gossmann, Axel [Department of Radiology, University of Cologne, Kerpener Str. 62, 50924 Cologne (Germany)], E-mail: axel.gossmann@uni-koeln.de

    2007-10-15

    Objective: To evaluate motion artifacts and patient acceptability of MR imaging of claustrophobic patients in an open 1.0 T scanner. Subjects and methods: Thirty six claustrophobic patients were enrolled prospectively, 34 of which had previous MR examinations in closed bore magnets. Anxiety and pain during MR examination in an open 1.0 T scanner were evaluated by visual analogue scales and various tests. Influence of motion artifacts on image quality was evaluated by two radiologists independently using a five-point scale. Additionally, 36 non-claustrophobic patients delivered a reference value of a non-claustrophobic population for the visual analogue anxiety scale. Results: Termination rate of MR imaging of highly claustrophobic patients decreased from 58.3% (n = 21) in closed bore magnets to 8.3% (n = 3) in the open scanner (p {<=} 0.001). Anxiety during MR examination was reduced from 87.1 {+-} 16.7 (closed magnets) to 30.4 {+-} 30.8 (open magnet) (p {<=} 0.001) on visual analogue scale ranging from 0 to 100. Influence of motion artifacts on image quality was very little (inter-rater reliability r = 0.74; p < 0.01). Conclusions: MR imaging using an open 1.0 T scanner yielded a significantly decreased anxiety and subsequently an improved acceptability in claustrophobic patients compared with closed bore magnets. Motion artifacts did not influence image quality.

  15. Effect of a neoprene sleeve on knee joint position sense during sitting open kinetic chain and supine closed kinetic chain tests.

    Science.gov (United States)

    Birmingham, T B; Kramer, J F; Inglis, J T; Mooney, C A; Murray, L J; Fowler, P J; Kirkley, S

    1998-01-01

    The primary objective of the present study was to compare the effect of a neoprene sleeve on knee joint position sense during a sitting open kinetic chain test and a supine closed kinetic chain test. Young (24 +/- 2 years old), healthy subjects (18 men and 18 women) performed knee joint angle replication tests during open kinetic chain knee extension (sitting) and closed kinetic chain leg press (supine with an axial load of 15% body weight) before and after application of a neoprene sleeve over the dominant knee. The improvement in ability to replicate joint angles after application of the sleeve (sleeve effect) was significantly less during the supine closed kinetic chain test (0.3 degree +/- 1.4 degrees) than during the sitting open kinetic chain test (1.2 degrees +/- 1.1 degrees). The sleeve effect was inversely related to subjects' performance without the sleeve during both the sitting open kinetic chain and supine closed kinetic chain tests, suggesting that some people may derive greater benefit from the sleeve than others. Although the sleeve effects were small, particularly during the supine closed kinetic chain test, 72% of subjects felt that the sleeve improved their overall test performance. Future research is needed to establish the functional relevance of the small sleeve effects observed and to identify the characteristics of people who might derive greatest benefit from sleeve use.

  16. A global wave-driven magnetohydrodynamic solar model with a unified treatment of open and closed magnetic field topologies

    Energy Technology Data Exchange (ETDEWEB)

    Oran, R.; Van der Holst, B.; Landi, E.; Jin, M.; Sokolov, I. V.; Gombosi, T. I., E-mail: oran@umich.edu [Atmospheric, Oceanic and Atmospheric Sciences, University of Michigan, 2455 Hayward, Ann Arbor, MI, 48105 (United States)

    2013-12-01

    We describe, analyze, and validate the recently developed Alfvén Wave Solar Model, a three-dimensional global model starting from the top of the chromosphere and extending into interplanetary space (out to 1-2 AU). This model solves the extended, two-temperature magnetohydrodynamics equations coupled to a wave kinetic equation for low-frequency Alfvén waves. In this picture, heating and acceleration of the plasma are due to wave dissipation and to wave pressure gradients, respectively. The dissipation process is described by a fully developed turbulent cascade of counterpropagating waves. We adopt a unified approach for calculating the wave dissipation in both open and closed magnetic field lines, allowing for a self-consistent treatment in any magnetic topology. Wave dissipation is the only heating mechanism assumed in the model; no geometric heating functions are invoked. Electron heat conduction and radiative cooling are also included. We demonstrate that the large-scale, steady state (in the corotating frame) properties of the solar environment are reproduced, using three adjustable parameters: the Poynting flux of chromospheric Alfvén waves, the perpendicular correlation length of the turbulence, and a pseudoreflection coefficient. We compare model results for Carrington rotation 2063 (2007 November-December) with remote observations in the extreme-ultraviolet and X-ray ranges from the Solar Terrestrial Relations Observatory, Solar and Heliospheric Observatory, and Hinode spacecraft and with in situ measurements by Ulysses. The results are in good agreement with observations. This is the first global simulation that is simultaneously consistent with observations of both the thermal structure of the lower corona and the wind structure beyond Earth's orbit.

  17. Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization

    Science.gov (United States)

    Degani-Katzav, Nurit; Klein, Moshe; Har-Even, Moran; Gortler, Revital; Tobi, Ruthi; Paas, Yoav

    2017-01-01

    Ivermectin (IVM) is a broad-spectrum anthelmintic drug used to treat human parasitic diseases like river blindness and lymphatic filariasis. By activating invertebrate pentameric glutamate-gated chloride channels (GluCl receptors; GluClRs), IVM induces sustained chloride influx and long-lasting membrane hyperpolarization that inhibit neural excitation in nematodes. Although IVM activates the C. elegans heteromeric GluClα/β receptor, it cannot activate a homomeric receptor composed of the C. elegans GluClβ subunits. To understand this incapability, we generated a homopentameric α7-GluClβ chimeric receptor that consists of an extracellular ligand-binding domain of an α7 nicotinic acetylcholine receptor known to be potentiated by IVM, and a chloride-selective channel domain assembled from GluClβ subunits. Application of IVM prior to acetylcholine inhibited the responses of the chimeric α7-GluClβR. Adding IVM to activated α7-GluClβRs, considerably accelerated the decline of ACh-elicited currents and stabilized the receptors in a non-conducting state. Determination of IVM association and dissociation rate constants and recovery experiments suggest that, following initial IVM binding to open α7-GluClβRs, the drug induces a conformational change and locks the ion channel in a closed state for a long duration. We further found that IVM also inhibits the activation by glutamate of a homomeric receptor assembled from the C. elegans full-length GluClβ subunits. PMID:28218274

  18. Characterization of a [open quotes]kissing[close quotes] hairpin complex derived from the human immunodeficiency virus genome

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Kung-Yao; Tinoco, Ignacio Jr. (Lawrence Berkeley Lab., CA (United States))

    1994-08-30

    Base-pair formation between hairpin loops-a [open quotes]kissing[close quotes] complex-is an RNA-folding motif that links two elements of RNA secondary structure. It is also a unique protein recognition site involved in regulation of ColE1 plasmid DNA replication. The trans-activation response element (TAR), a hairpin and bulge at the 5[prime] end of the untranslated leader region of the human immunodeficiency virus 1 mRNA, enhances the transcription of the virus and is necessary for viral replication. Gel electrophoresis and absorbance melting curves indicate that a synthesized RNA hairpin (Tar*-16) with a loop sequence complementary to the TAR loop sequence (CUGGGA) associates specifically with a 16-nucleotide TAR hairpin (Tar-16) to form a stable complex. RNase T1 probing indicates that the three guanines in the Tar-16 loop become inaccessible in the complex. NMR imino proton spectra reveal that 5 base pairs are formed between the two hairpin loops (Tar-16 and Tar*-16); only the adenine at the 3[prime] terminus of the TAR loop does not form a base pair with the 5[prime]-terminal uracil of the complementary loop. A 14-nucleotide hairpin [CCUA-(UCCCAG)UAGG] with a loop sequence complementary to the TAR loop is conserved within the gag gene of human immunodeficiency virus 1. A synthesized RNA hairpin corresponding to this conserved sequence also binds to the Tar-16 hairpin with high affinity. It is possible that the same RNA loop-loop interaction occurs during the viral life cycle. 40 refs., 7 figs.

  19. Open and closed models of intensive care unit have different influences on infectious complications in a tertiary care center: A retrospective data analysis.

    Science.gov (United States)

    El-Kersh, Karim; Guardiola, Juan; Cavallazzi, Rodrigo; Wiemken, Timothy L; Roman, Jesse; Saad, Mohamed

    2016-12-01

    Infectious complications in the intensive care unit (ICU) are associated with higher morbidity, mortality, and increased health care use. Here, we report the results of implementing 2 different models (open vs closed) on infectious complications in the ICU. The closed ICU model was associated with 52% reduction in ventilator-associated pneumonia rate (P = .038) and 25% reduction in central line-associated bloodstream infection rate (P = .631). We speculate that a closed ICU model allows clinical leadership centralization that further facilitates standardized care delivery that translates into fewer infectious complications.

  20. The Best of Both Worlds: The Benefits of Open-specialized and Closed-diverse Syndication Networks for New Ventures' Success.

    Science.gov (United States)

    Ter Wal, Anne L J; Alexy, Oliver; Block, Jörn; Sandner, Philipp G

    2016-09-01

    Open networks give actors non-redundant information that is diverse, while closed networks offer redundant information that is easier to interpret. Integrating arguments about network structure and the similarity of actors' knowledge, we propose two types of network configurations that combine diversity and ease of interpretation. Closed-diverse networks offer diversity in actors' knowledge domains and shared third-party ties to help in interpreting that knowledge. In open-specialized networks, structural holes offer diversity, while shared interpretive schema and overlap between received information and actors' prior knowledge help in interpreting new information without the help of third parties. In contrast, actors in open-diverse networks suffer from information overload due to the lack of shared schema or overlapping prior knowledge for the interpretation of diverse information, and actors in closed-specialized networks suffer from overembeddedness because they cannot access diverse information. Using CrunchBase data on early-stage venture capital investments in the U.S. information technology sector, we test the effect of investors' social capital on the success of their portfolio ventures. We find that ventures have the highest chances of success if their syndicating investors have either open-specialized or closed-diverse networks. These effects are manifested beyond the direct effects of ventures' or investors' quality and are robust to controlling for the possibility that certain investors could have chosen more promising ventures at the time of first funding.

  1. Silver(I)-catalyzed dual activation of propargylic alcohol and aziridine/azetidine: triggering ring-opening and endo-selective ring-closing in a cascade.

    Science.gov (United States)

    Bera, Milan; Roy, Sujit

    2009-11-20

    [Ag(COD)(2)]PF(6) catalyzes the reaction between propargyl alcohols and N-tosylaziridines/azetidines leading to a diverse range of N,O-heterocycles, namely, oxazines, oxazepines, and oxazocines via ring-opening and ring-closing in a cascade.

  2. Accuracy of implant transfer with open-tray and closed-tray impression techniques and surface detail reproduction of the tooth during impression

    Directory of Open Access Journals (Sweden)

    Hakimeh Siadat

    2012-01-01

    Full Text Available Background and Aims: Accurate recording of implant location is required to achieve passive fit and have the implants without stress concentration. The aim of this in-vitro study was to evaluate the dimensional and angular accuracy of open-tray and closed-tray impression techniques using polyether impression material and also to assess the surface detail reproduction of the tooth while impression making.Materials and Methods: One reference metal model with 2 implants (Implantium on the position of the maxillary second premolar and first molar and one molar tooth for evaluation of surface details was prepared. 27 polyether impressions of these models were made (9 using open-tray, 9 using closed-tray techniques and 9 were made just of the surface of the teeth without any implants. Impressions were poured with ADA type IV stone. Coordinate Measuring Machine was used for measuring the dimensional accuracy and video measuring machine for surface detail reproduction. All of these measurements were compared with the measurements on the reference model. Data were analyzed by and compared by T-test and One-way ANOVA.Results: There was a significant statistical difference between open-tray and closed-tray techniques (P0.05.Conclusion: The accuracy of open-tray impression technique was more than closed-tray technique. The surface detail reproduction of the tooth was not affected by impression technique.

  3. On the relation between the fundamental equation of thermodynamics and the energy balance equation in the context of closed and open systems

    NARCIS (Netherlands)

    Knuiman, J.T.; Barneveld, P.A.

    2012-01-01

    In this paper, we elaborate on the connection between the fundamental equation of thermodynamics, which is essentially the combination of the First and Second Laws of thermodynamics, and the energy balance equation in the context of closed and open systems. We point out some misinterpretations in

  4. On the relation between the fundamental equation of thermodynamics and the energy balance equation in the context of closed and open systems

    NARCIS (Netherlands)

    Knuiman, J.T.; Barneveld, P.A.

    2012-01-01

    In this paper, we elaborate on the connection between the fundamental equation of thermodynamics, which is essentially the combination of the First and Second Laws of thermodynamics, and the energy balance equation in the context of closed and open systems. We point out some misinterpretations in at

  5. An aircraft case study of the spatial transition from closed to open mesoscale cellular convection over the Southeast Pacific

    Directory of Open Access Journals (Sweden)

    R. Wood

    2010-07-01

    Full Text Available Aircraft measurements are presented from 27 to 28 October 2008 case study of the VOCALS Regional Experiment (REx over the remote subtropical southeast Pacific (18° S, 80° W. Data from two aircraft that took measurements approximately twelve hours apart but in the same advected airmass are used to document a remarkably sharp spatial transition in marine boundary layer (MBL, cloud, and aerosol structure across the boundary between a well-mixed MBL containing overcast closed mesoscale cellular stratocumulus, and a pocket of open cells (POC with significantly lower cloud cover. Long (~190–250 km straight and level flight legs at three levels in the marine boundary layer and one level in the lower free troposphere permit sampling of the closed cells, the POC, and a 20–30 km wide transition zone with distinctly different structure from the two airmasses on either side. The POC region consists of intermittent active and strongly precipitating cumulus clouds rising and detraining into patches of drizzling but quiescent stratiform cloud which is optically thin especially toward its edges.

    Mean cloud-base precipitation rates inside the POC are several mm d−1, but rates in the closed cell region are not greatly lower than this, which suggests that precipitation is not a sufficient condition for POC formation from overcast stratocumulus. Despite similar cloud-base precipitation rates in the POC and overcast region, much of the precipitation (>90% evaporates below cloud in the overcast region, while there is significant surface precipitation inside the POC. In the POC and transition region, although the majority of the condensate is in the form of drizzle, the integrated liquid water path is remarkably close to that expected for a moist adiabatic parcel rising from cloud base to top.

    The transition zone between the POC and the closed cells often consists of thick "boundary cell" clouds producing mean surface precipitation

  6. Eye redness

    Science.gov (United States)

    Bloodshot eyes; Red eyes; Scleral injection; Conjunctival injection ... There are many causes of a red eye or eyes. Some are medical emergencies. Others are a cause for concern, but not an emergency. Many are nothing to worry about. Eye ...

  7. [The problem of crossed eye-hand dominance (author's transl)].

    Science.gov (United States)

    Niederlandová, Z

    1975-06-01

    The manual and visual dominance of one side has in recent times attracted much attention from many aspects. Crossed dominance (right eye - left hand) seems significant in strabismus of childhood. For the first time recently it has become obvious, that the structure of the body and its muscles, especially of the trunk is asymmetrical. Even in normal persons the centre of gravity of the body is not in the midline, but displaced usually some distance to the left. We have examined the stabilographic proportions in 30 normal and 30 squinting children. In the normal children, with closed eyes the centre of gravity of the body was displaced in 80% to the right, in the quinting children this point was in 73% displaced to the left. We can deduce from this, that the marked right-eye dominance in squinting children is responsible for the displacement of the centre of gravity. If the right eye is open, then the vertical body-axis tends a little to the left. This tendency demands an increase of muscle tone on the left side of the body and with this a displacement of the body centre of gravity to the left; this not only, when the right eye is open, but also, when both eyes are opened or closed. From our experience this adjustment is especially suited to normalise the working together of the hand and the eye in squinting children.

  8. Simultaneous Eye Tracking and Blink Detection with Interactive Particle Filters

    Directory of Open Access Journals (Sweden)

    Mohan M. Trivedi

    2008-04-01

    Full Text Available We present a system that simultaneously tracks eyes and detects eye blinks. Two interactive particle filters are used for this purpose, one for the closed eyes and the other one for the open eyes. Each particle filter is used to track the eye locations as well as the scales of the eye subjects. The set of particles that gives higher confidence is defined as the primary set and the other one is defined as the secondary set. The eye location is estimated by the primary particle filter, and whether the eye status is open or closed is also decided by the label of the primary particle filter. When a new frame comes, the secondary particle filter is reinitialized according to the estimates from the primary particle filter. We use autoregression models for describing the state transition and a classification-based model for measuring the observation. Tensor subspace analysis is used for feature extraction which is followed by a logistic regression model to give the posterior estimation. The performance is carefully evaluated from two aspects: the blink detection rate and the tracking accuracy. The blink detection rate is evaluated using videos from varying scenarios, and the tracking accuracy is given by comparing with the benchmark data obtained using the Vicon motion capturing system. The setup for obtaining benchmark data for tracking accuracy evaluation is presented and experimental results are shown. Extensive experimental evaluations validate the capability of the algorithm.

  9. Whole exome sequencing implicates eye development, the unfolded protein response and plasma membrane homeostasis in primary open-angle glaucoma

    Science.gov (United States)

    Souzeau, Emmanuelle; Sharma, Shiwani; Landers, John; Mills, Richard; Goldberg, Ivan; Healey, Paul R.; Graham, Stuart; Hewitt, Alex W.; Mackey, David A.; Galanopoulos, Anna; Casson, Robert J.; Ruddle, Jonathan B.; Ellis, Jonathan; Leo, Paul; Brown, Matthew A.; MacGregor, Stuart; Lynn, David J.; Burdon, Kathryn P.; Craig, Jamie E.

    2017-01-01

    Purpose To identify biological processes associated with POAG and its subtypes, high-tension (HTG) and normal-tension glaucoma (NTG), by analyzing rare potentially damaging genetic variants. Methods A total of 122 and 65 unrelated HTG and NTG participants, respectively, with early onset advanced POAG, 103 non-glaucoma controls and 993 unscreened ethnicity-matched controls were included in this study. Study participants without myocilin disease-causing variants and non-glaucoma controls were subjected to whole exome sequencing on an Illumina HiSeq2000. Exomes of participants were sequenced on an Illumina HiSeq2000. Qualifying variants were rare in the general population (MAF < 0.001) and potentially functionally damaging (nonsense, frameshift, splice or predicted pathogenic using SIFT or Polyphen2 software). Genes showing enrichment of qualifying variants in cases were selected for pathway and network analysis using InnateDB. Results POAG cases showed enrichment of rare variants in camera-type eye development genes (p = 1.40×10–7, corrected p = 3.28×10–4). Implicated eye development genes were related to neuronal or retinal development. HTG cases were significantly enriched for key regulators in the unfolded protein response (UPR) (p = 7.72×10–5, corrected p = 0.013). The UPR is known to be involved in myocilin-related glaucoma; our results suggest the UPR has a role in non-myocilin causes of HTG. NTG cases showed enrichment in ion channel transport processes (p = 1.05×10–4, corrected p = 0.027) including calcium, chloride and phospholipid transporters involved in plasma membrane homeostasis. Network analysis also revealed enrichment of the MHC Class I antigen presentation pathway in HTG, and the EGFR1 and cell-cycle pathways in both HTG and NTG. Conclusion This study suggests that mutations in eye development genes are enriched in POAG. HTG can result from aberrant responses to protein misfolding which may be amenable to molecular chaperone therapy. NTG

  10. 17 CFR 147.3 - General requirement of open meetings; grounds upon which meetings may be closed.

    Science.gov (United States)

    2010-04-01

    ... COMMODITY FUTURES TRADING COMMISSION OPEN COMMISSION MEETINGS § 147.3 General requirement of open meetings... including, but not limited to: (A) Reports of stocks of grain, such as Forms 38, 38C, 38M and 38T, required... memoranda and work-product concerning examinations and other inquiries or investigations and...

  11. Research on Embedded Eye Tracking System Based on OpenCV%基于 Ope nC V的嵌入式人眼追踪系统研究

    Institute of Scientific and Technical Information of China (English)

    胡玉峰

    2014-01-01

    对于视觉控制系统而言,如何定位并追踪眼睛,判断眼睛状态是关键的一步。文中提出了一种基于OpenCV的人眼识别和跟踪方法,利用摄像头和OpenCV的相关函数在嵌入式平台上实现了人眼的识别与追踪。此外,还通过实验表明,该方法可满足对人眼的识别,且拥有较好的识别速度和识别率,故具有一定的实用性。%For the visual control system , it is very important to locate and track eyes position and judge the state of eyes .A detection method for human eye identification and tracking of the video image based on OpenCV is proposed in this paper .This method combines camera equipment and OpenCV correlation function and designs a sys -tem to achieve the goal of eye detection and tracking on the embedded platform .The experimental results show this method meets requirements of human eye recognition with high recognition speed and accuracy , and is of practical value.

  12. Using image processing technology and mathematical algorithm in the automatic selection of vocal cord opening and closing images from the larynx endoscopy video.

    Science.gov (United States)

    Kuo, Chung-Feng Jeffrey; Chu, Yueng-Hsiang; Wang, Po-Chun; Lai, Chun-Yu; Chu, Wen-Lin; Leu, Yi-Shing; Wang, Hsing-Won

    2013-12-01

    The human larynx is an important organ for voice production and respiratory mechanisms. The vocal cord is approximated for voice production and open for breathing. The videolaryngoscope is widely used for vocal cord examination. At present, physicians usually diagnose vocal cord diseases by manually selecting the image of the vocal cord opening to the largest extent (abduction), thus maximally exposing the vocal cord lesion. On the other hand, the severity of diseases such as vocal palsy, atrophic vocal cord is largely dependent on the vocal cord closing to the smallest extent (adduction). Therefore, diseases can be assessed by the image of the vocal cord opening to the largest extent, and the seriousness of breathy voice is closely correlated to the gap between vocal cords when closing to the smallest extent. The aim of the study was to design an automatic vocal cord image selection system to improve the conventional selection process by physicians and enhance diagnosis efficiency. Also, due to the unwanted fuzzy images resulting from examination process caused by human factors as well as the non-vocal cord images, texture analysis is added in this study to measure image entropy to establish a screening and elimination system to effectively enhance the accuracy of selecting the image of the vocal cord closing to the smallest extent.

  13. Application of Graphics Opening the Eyes Method in Advertising Design%图形开眼法在广告设计中的运用

    Institute of Scientific and Technical Information of China (English)

    郑国喜

    2012-01-01

    以文学中的画龙点睛之笔为启示,分析了图形开眼方法及图形开眼原则,论述了在广告设计中如何从图形的影像、图形的叠加关系、图形的放置方式、图形的切割变化、图形的逻辑关系等方面进行变化,使图形成为整个广告设计的画龙点睛之笔。在此基础上,提出了应根据广告主题灵活运用图形开眼法来增加广告的趣味性与联想空间,为广告设计的图形处理方法提供参考和借鉴。%Taking finishing touch in the literature as enlightenment,it analyzed opening the eyes method of graphical and principles of graphics,discussed how to change from images of graphics,overlay relationship of graphics,placement of graphics,cutting changes of graphics,the logic relation of the graphics in advertising.Graphics become finishing touch of the entire advertising.On this basis,it proposed advertising theme should be based on flexible use of graphical opening the eyes method to Increase the interest and imagination of advertising,it provided reference and learn for graphics design of advertising.

  14. Robotic and Open Radical Prostatectomy: The First Prospective Randomised Controlled Trial Fuels Debate Rather than Closing the Question.

    Science.gov (United States)

    Fossati, Nicola; Wiklund, Peter; Rochat, Charles-Henry; Montorsi, Francesco; Dasgupta, Prokar; Sanchez-Salas, Rafael; Canda, Abdullah E; Piechaud, Thierry; Artibani, Walter; Mottrie, Alexandre

    2017-03-01

    Despite the finally acquired level 1 evidence, the urologic debate on open versus robotic prostatectomy still persists. This trial from Brisbane will encourage future studies that will better inform this debate and define what robotic surgery offers.

  15. [Long-term results of closed mitral commissurotomy--comparative study of closed mitral commissurotomy (CMC), open mitral commissurotomy (OMC) and mitral valve replacement (MVR)].

    Science.gov (United States)

    Suzuki, S; Kondo, J; Imoto, K; Kajiwara, H; Tobe, M; Sakamoto, A; Isoda, S; Yamazaki, I; Noishiki, Y; Matsumoto, A

    1993-09-01

    As the technique of open heart surgery has improved, CMC has been abandoned in favor of OMC and MVR. We evaluated and compared the results of CMC, OMC and MVR. METHOD. Between 1965 and 1978, 141 patients with mitral stenosis (MS) underwent CMC, and late follow-up obtained in 117 (83%) of them (CMC group). Between 1980 and 1989, 72 patients and 37 patients underwent OMC (OMC group) and MVR (MVR group), respectively. Cumulative follow-up periods were 1982, 632 and 200 patient-years in the CMC, OMC and MVR groups, respectively. RESULTS. (1) Survival rate; In the CMC group there were 2 operative deaths due to severe mitral regurgitation (MR). There were 17 late deaths, due to reoperations in 4 patients, cerebral infarction in 4 patients, congestive heart failure in 3 patients, myocardial infarction in 2 patients and unknown causes in 4 patients. The survival rate was 95%, 91% and 86% at 5, 10 and 15 years, respectively, in the CMC group. In the OMC and MVR groups there was no death. (2) The event free rate was 89%, 79% and 58% at 5, 10 and 15 years, respectively, in the CMC group, 97% and 97% at 5 and 10 years in the OMC group, and 95% and 90% at 4 and 5 years in the MVR group. (3) Reoperations; In the CMC group of 40 patients (34%) required reoperations in an average of 10.4 years after the initial operation, due to re-MS in 22 patients, MR in 10 patients and MRS in the 8 patients. Reoperative findings consisted of clefts in the mitral leaflets in 7 patients. There were pulmonary hypertension in 15 patients and tricuspid regurgitation in 22 patients. Fourteen patients underwent tricuspid anuloplasty and one patient underwent a tricuspid valve replacement. In the OMC group one patient required a reoperation due to MR; in the MVR group one patient required a reoperation due to a thrombosed valve. CONCLUSION. In the CMC group the survival rate and the event free rate were lower, and the rate of reoperation was higher than in the other two groups.

  16. Using the non-wetting properties of a cesiated surface to create a free standing {open_quotes}slab{close_quotes} of superfluid helium four

    Energy Technology Data Exchange (ETDEWEB)

    Williams, M.; Giese, C.; Halley, J.W.

    1995-04-01

    The authors report calculations showing that it should be possible to suspend a {open_quotes}slab{close_quotes} of superfuid liquid helium across a hole in a horizontal plate if the surface of the plate and hole are covered with cesium. The depth of the fluid which can be suspended is inversely proportional to the diameter of the hole. They report preliminary experiments to observe this effect, using a capacitance bridge to measure the depth. The capacitance bridge is sensitive to changes of 0.1 mm in liquid depth. The possible applications of this technique to carry out a proposed experiment to observe condensate mediated transmission of helium atoms {open_quotes}through{close_quotes} the slab will be briefly discussed.

  17. Evaluation of Orbital-and Ground State Energies of Some Open-and Closed-Shell Atoms over Integer and Noninteger Slater Type Orbitals

    Institute of Scientific and Technical Information of China (English)

    YAKAR,Yusuf

    2007-01-01

    Ab initio calculations of the orbital and the ground state energies of some open- and closed-shell atoms over Slater type orbitals with quantum numbers integer and Slater type orbitals with quantum numbers noninteger have been performed. In order to increase the efficiency of these calculations the atomic two-electron integrals were expressed in terms of incomplete beta function. Results were observed to be in good agreement with the literature.

  18. Comments on {open_quotes}datalog: A self-contained tutorial{close_quotes} by S. Ceri, G. Gottlob, and L. Tanca

    Energy Technology Data Exchange (ETDEWEB)

    Kalinichenko, L.A.

    1992-05-01

    The construction of deductive databases requires a combination of independently developed methods for database management and logic programming. This approach has rapidly (literally in the last 5-6 years) coalesced within projects associated with combining new information technologies and fifth-generation computer systems (the strategic programs of the USA and Japan. and the ESPRIT program in Europe). Work has proceeded so rapidly and new methods have appeared at such a rapid pace that practically no information is available in the Russian-language literature. The number of publications in this area is large. and the sources are very diverse. As a result, providing an introduction to deductive databases is a nontrivial problem. However, the problem has been somewhat simplified by the recent appearance of two monographs that summarize achievements in this area: J. Ullman`s two-volume {open_quotes}Principles of Database and Knowledgebase Systems{close_quotes}, and the book {open_quotes}Logic Programming and Databases{close_quotes}, by Ceri, Gottlob, and Tanca. Ullman`s two volumes provide an exhaustive overview of the subject: They also consider results that are already considers classical. The book by Ceri, et. al., is concerned exclusively with new methods that are promising and have practical applications. The publisher {open_quotes}Mir{close_quotes} has completed a translation of this book. Publication of the article by Ceri, Gottlob, and Tanca makes it possible to efficiently inform the readers of {open_quotes}Programmirovanie{close_quotes} about the basic results in the indicated areas. It is the first publication of this type of article. It is base on a report made at the Polytechnic Institute of Milan and was provided through the courtesy of S. Ceri for publication in our magazine.

  19. Healthy Eyes

    Science.gov (United States)

    ... los Ojos Cómo hablarle a su oculista Healthy Eyes Having a comprehensive dilated eye exam is one ... or contact lenses. What is a comprehensive dilated eye exam? A comprehensive dilated eye exam is a ...

  20. Establishing Age-Adjusted Reference Ranges for Iris-Related Parameters in Open Angle Eyes with Anterior Segment Optical Coherence Tomography.

    Directory of Open Access Journals (Sweden)

    Jeffrey R Peterson

    Full Text Available Define criteria for iris-related parameters in an adult open angle population as measured with swept source Fourier domain anterior segment optical coherence tomography (ASOCT.Ninety-eight eyes of 98 participants with open angles were included and stratified into 5 age groups (18-35, 36-45, 46-55, 56-65, and 66-79 years. ASOCT scans with 3D mode angle analysis were taken with the CASIA SS-1000 (Tomey Corporation, Nagoya, Japan and analyzed using the Anterior Chamber Analysis and Interpretation software. Anterior iris surface length (AISL, length of scleral spur landmark (SSL to pupillary margin (SSL-to-PM, iris contour ratio (ICR = AISL/SSL-to-PM, pupil radius, radius of iris centroid (RICe, and iris volume were measured. Outcome variables were summarized for all eyes and age groups, and mean values among age groups were compared using one-way analysis of variance. Stepwise regression analysis was used to investigate demographic and ocular characteristic factors that affected each iris-related parameter.Mean (±SD values were 2.24 mm (±0.46, 4.06 mm (±0.27, 3.65 mm (±0.48, 4.16 mm (±0.47, 1.14 (±0.04, 1.51 mm2 (±0.23, and 38.42 μL (±4.91 for pupillary radius, RICe, SSL-to-PM, AISL, ICR, iris cross-sectional area, and iris volume, respectively. Both pupillary radius (P = 0.002 and RICe (P = 0.027 decreased with age, while SSL-to-PM (P = 0.002 and AISL increased with age (P = 0.001. ICR (P = 0.54 and iris volume (P = 0.49 were not affected by age.This study establishes reference values for iris-related parameters in an adult open angle population, which will be useful for future studies examining the role of iris changes in pathologic states.

  1. Time estimate (t{sub opening} + t{sub closing}) of shutter of an X-ray equipment using a digital chronometer; Estimativa do tempo (t{sub opening} + t{sub closing}) do shutter de um equipamento de raios-X utilizando um cronometro digital

    Energy Technology Data Exchange (ETDEWEB)

    Quaresma, D.S.; Oliveira, P.H.T.M.; Gallo, V.F.M.; Jordao, B.O.; Carvalho, R.J., E-mail: dansq@on.br [Observatorio Nacional (ON), Rio de Janeiro, RJ (Brazil); Cardoso, R.S.; Peixoto, J.G.P.

    2014-07-01

    In this work the measurement of time t{sub opening} + t{sub closing} opening and closing the shutter of Pantak HF160 X-ray equipment was performed. It is understood by the shutter device responsible for allowing or not the flow of X-rays that are produced by the X-ray tube through the orifice of a shield. To estimate the running time for a digital chronometer calibrated in the Time Service Division (DSHO) National Observatory (ON) was used. (author)

  2. Open- and Closed-Skill Exercise Interventions Produce Different Neurocognitive Effects on Executive Functions in the Elderly: A 6-Month Randomized, Controlled Trial

    Directory of Open Access Journals (Sweden)

    Chia-Liang Tsai

    2017-09-01

    Full Text Available This study aimed to explore the effects of open- and closed-skill exercise interventions on the neurocognitive performance of executive functions in the elderly. Sixty-four healthy elderly males were randomly assigned to either a closed-skill (bike riding or brisk walking/jogging, n = 22, open-skill (table tennis, n = 21, or control (n = 21 group. Various neuropsychological [e.g., accuracy rates (AR and reaction time (RT] and electrophysiological [e.g., event-related potential (ERP P3 component] measures were assessed during a variant of the task-switching paradigm, as well as an N-back task at baseline and after either a 6-month exercise intervention or control period. The results showed that, when performing the task-switching paradigm, the two exercise groups relative to control group showed significantly faster RTs in the switch trials after the exercise intervention. However, the RT facilitation in the non-switch and switch trials post-exercise relative to pre-exercise only emerged in the open-skill group. In terms of the N-back task, the two exercise groups significantly increased ARs in the 1-back condition after the exercise intervention, and the beneficial AR effect on the 2-back condition only emerged in the closed-skill group. In addition, the two exercise groups exhibited significantly larger P3 amplitudes on the frontal-to-parietal cortex areas after the exercise intervention relative to the baseline when performing the two cognitive tasks. These neurocognitive results still remained unchanged even when the confounding factors (e.g., cardiorespiratory fitness, social participation, and BMI were controlled for. The present study concluded that, although 6-month open- and closed-skill exercise interventions facilitate overall electrophysiological effects (i.e., increased ERP P3 amplitudes on the frontal-to-parietal cortices in the elderly, the two exercise modes produced different levels of neuropsychologically beneficial effects on

  3. Evaluation of Capiox FX05 oxygenator with an integrated arterial filter on trapping gaseous microemboli and pressure drop with open and closed purge line.

    Science.gov (United States)

    Qiu, Feng; Peng, Sophia; Kunselman, Allen; Ündar, Akif

    2010-11-01

    Gaseous microemboli (GME) remain a challenge for cardiopulmonary bypass (CPB) because there is a positive correlation between microemboli exposure during CPB and postoperative neurological injury. Thus, minimizing the number of GME delivered to pediatric patients undergoing CPB procedures would lead to better clinical outcomes. In this study, we used a simulated CPB model to evaluate the effectiveness of capturing GME and the degree of membrane pressure drop for a new membrane oxygenator, Capiox Baby FX05 (Terumo Corporation,Tokyo, Japan), which has an integrated arterial filter with open and closed purge line.We used identical components in this study as our clinical CPB circuit. Three emboli detection and classification quantifier transducers were placed at prepump, preoxygenator, and postoxygenator sites in the circuit.Two flow probes as well as three pressure transducers were placed upstream and downstream of the oxygenator. The system was primed with human blood titrated to 30% hematocrit with Lactated Ringer’s solution.A bolus of air (1 mL) was injected in the prepump site under nonpulsatile perfusion mode at three flow rates (500,750, and 1000 mL/min) and with the purge line either open or closed. Six trials were performed for each unique set-up for a total of 36 trials.All trials were conducted at 35°C. The circuit pressure was kept constant at 100 mm Hg. Both the size and quantity of microemboli detected at postoxygenator site were recorded for 5 min postair injection. It was found that total counts of GME were significantly reduced with the purge line open when compared to keeping the purge line closed (P purge line closed compared to keeping the purge line open at flow rates of 750 mL/min and 1000 mL/min (P purge line open and closed, which is due to the small arteriovenous (A-V) shunt(P < 0.001). These results suggest that the integrated arterial filter of the Capiox FX05 oxygenator significantly improves the capturing of GME but has little impact on

  4. Hawk eyes I: diurnal raptors differ in visual fields and degree of eye movement.

    Directory of Open Access Journals (Sweden)

    Colleen T O'Rourke

    Full Text Available BACKGROUND: Different strategies to search and detect prey may place specific demands on sensory modalities. We studied visual field configuration, degree of eye movement, and orbit orientation in three diurnal raptors belonging to the Accipitridae and Falconidae families. METHODOLOGY/PRINCIPAL FINDINGS: We used an ophthalmoscopic reflex technique and an integrated 3D digitizer system. We found inter-specific variation in visual field configuration and degree of eye movement, but not in orbit orientation. Red-tailed Hawks have relatively small binocular areas (∼33° and wide blind areas (∼82°, but intermediate degree of eye movement (∼5°, which underscores the importance of lateral vision rather than binocular vision to scan for distant prey in open areas. Cooper's Hawks' have relatively wide binocular fields (∼36°, small blind areas (∼60°, and high degree of eye movement (∼8°, which may increase visual coverage and enhance prey detection in closed habitats. Additionally, we found that Cooper's Hawks can visually inspect the items held in the tip of the bill, which may facilitate food handling. American Kestrels have intermediate-sized binocular and lateral areas that may be used in prey detection at different distances through stereopsis and motion parallax; whereas the low degree eye movement (∼1° may help stabilize the image when hovering above prey before an attack. CONCLUSIONS: We conclude that: (a there are between-species differences in visual field configuration in these diurnal raptors; (b these differences are consistent with prey searching strategies and degree of visual obstruction in the environment (e.g., open and closed habitats; (c variations in the degree of eye movement between species appear associated with foraging strategies; and (d the size of the binocular and blind areas in hawks can vary substantially due to eye movements. Inter-specific variation in visual fields and eye movements can influence

  5. Comparison of the diagnostic ability of Moorfield′s regression analysis and glaucoma probability score using Heidelberg retinal tomograph III in eyes with primary open angle glaucoma

    Directory of Open Access Journals (Sweden)

    Jindal Shveta

    2010-01-01

    Full Text Available Purpose: To compare the diagnostic performance of the Heidelberg retinal tomograph (HRT glaucoma probability score (GPS with that of Moorfield′s regression analysis (MRA. Materials and Methods: The study included 50 eyes of normal subjects and 50 eyes of subjects with early-to-moderate primary open angle glaucoma. Images were obtained by using HRT version 3.0. Results: The agreement coefficient (weighted k for the overall MRA and GPS classification was 0.216 (95% CI: 0.119 - 0.315. The sensitivity and specificity were evaluated using the most specific (borderline results included as test negatives and least specific criteria (borderline results included as test positives. The MRA sensitivity and specificity were 30.61 and 98% (most specific and 57.14 and 98% (least specific. The GPS sensitivity and specificity were 81.63 and 73.47% (most specific and 95.92 and 34.69% (least specific. The MRA gave a higher positive likelihood ratio (28.57 vs. 3.08 and the GPS gave a higher negative likelihood ratio (0.25 vs. 0.44.The sensitivity increased with increasing disc size for both MRA and GPS. Conclusions: There was a poor agreement between the overall MRA and GPS classifications. GPS tended to have higher sensitivities, lower specificities, and lower likelihood ratios than the MRA. The disc size should be taken into consideration when interpreting the results of HRT, as both the GPS and MRA showed decreased sensitivity for smaller discs and the GPS showed decreased specificity for larger discs.

  6. Applied eye tracking research

    NARCIS (Netherlands)

    Jarodzka, Halszka

    2011-01-01

    Jarodzka, H. (2010, 12 November). Applied eye tracking research. Presentation and Labtour for Vereniging Gewone Leden in oprichting (VGL i.o.), Heerlen, The Netherlands: Open University of the Netherlands.

  7. Applied eye tracking research

    NARCIS (Netherlands)

    Jarodzka, Halszka

    2011-01-01

    Jarodzka, H. (2010, 12 November). Applied eye tracking research. Presentation and Labtour for Vereniging Gewone Leden in oprichting (VGL i.o.), Heerlen, The Netherlands: Open University of the Netherlands.

  8. Work-Related Eye Injuries: Important Occupational Health Problem in Northern Thailand.

    Science.gov (United States)

    Chaikitmongkol, Voraporn; Leeungurasatien, Thidarat; Sengupta, Sabyasachi

    2015-01-01

    This study was aimed to determine demographics, clinical characteristics, and factors associated with work-related eye injury in Northern Thailand. A prospective case series. Eye injuries from any cause treated at a university-based hospital in Northern Thailand from March 2007 to June 2008 were included. In addition to comprehensive eye examination and standard treatments, patients' occupation, type of activity at the time of injury, alcohol consumption, and eye protection were studied. Eye injuries were classified based on the Birmingham Eye Trauma Terminology System. Demographic and clinical data were documented using a form adapted from the United States Eye Injury Registry. Of the 101 eyes (97 patients) with work-related injury, 94% were men with a mean age of 39.5 ± 12.9 years (range, 19-72 years). Ninety-eight percent (95/97 patients) did not use protective eyewear. Open-globe injuries were found in 58/101 (57%) eyes. Agricultural workers experienced a higher number of open-globe injuries (37/58 eyes, 64%), whereas construction workers experienced a higher number of closed-globe injuries (25/43 eyes, 58%). In multivariable logistic regression models, nailing (odds ratio, 97.2; 95% confidence interval, 2.6-363.4; P = 0.01) and motorized grass trimming (odds ratio, 14.3; 95% confidence interval, 1.0-206.2; P = 0.05) were significantly associated with open-globe injuries when compared with closed-globe injuries. Significantly greater numbers of eyes with open-globe injuries had final vision equivalent to legal blindness (visual acuity, Thailand. Protective eyewear should be aggressively promoted among workers engaged in nailing and motorized grass trimming.

  9. Catalyst-like modulation of transition states for CFTR channel opening and closing: New stimulation strategy exploits nonequilibrium gating

    OpenAIRE

    Csanády, László; Töröcsik, Beáta

    2014-01-01

    Cystic fibrosis transmembrane conductance regulator (CFTR) is the chloride ion channel mutated in cystic fibrosis (CF) patients. It is an ATP-binding cassette protein, and its resulting cyclic nonequilibrium gating mechanism sets it apart from most other ion channels. The most common CF mutation (ΔF508) impairs folding of CFTR but also channel gating, reducing open probability (Po). This gating defect must be addressed to effectively treat CF. Combining single-channel and macroscopic current ...

  10. Closing gaps between open software and public data in a hackathon setting: User-centered software prototyping.

    Science.gov (United States)

    Busby, Ben; Lesko, Matthew; Federer, Lisa

    2016-01-01

    In genomics, bioinformatics and other areas of data science, gaps exist between extant public datasets and the open-source software tools built by the community to analyze similar data types.  The purpose of biological data science hackathons is to assemble groups of genomics or bioinformatics professionals and software developers to rapidly prototype software to address these gaps.  The only two rules for the NCBI-assisted hackathons run so far are that 1) data either must be housed in public data repositories or be deposited to such repositories shortly after the hackathon's conclusion, and 2) all software comprising the final pipeline must be open-source or open-use.  Proposed topics, as well as suggested tools and approaches, are distributed to participants at the beginning of each hackathon and refined during the event.  Software, scripts, and pipelines are developed and published on GitHub, a web service providing publicly available, free-usage tiers for collaborative software development. The code resulting from each hackathon is published at https://github.com/NCBI-Hackathons/ with separate directories or repositories for each team.

  11. TO COMPARE FUNCTIONAL OUTCOME, COMPLICATIONS & RESULTS OF OPEN REDUCTION & INTERNAL FIXATION WITH CLOSED REDUCTION & EXTERNAL FIXATION IN VOLAR DISPLACED DISTAL RADIAL FRACTURE

    Directory of Open Access Journals (Sweden)

    Ketan Gupta

    2015-02-01

    Full Text Available Distal radius fractures account for 17% of all fractures in adults. The fracture of the lower end of radius crush the mechanical foundation of man‟s most elegant tool, the hand. No other fracture has a greater potential to devastate hand function. Today, o pen reduction of the fracture with internal fixation and closed reduction of the fracture with external fixation, forms the mainstay of the treatment of an uncomplicated distal end radius fracture in a patient unless specifically contraindicated. AIMS AND OBJECTIVES: To compare functional outcome, complications & results of two commonly used surgical methods; Open reduction & internal fixation with volar placed buttress plate and Closed reduction & external fixation with „Jess fixator‟ and internal fixation with „k - wire‟ in volar displaced distal radial fractures. MATERIALS AND METHODS : Total 30 cases were included in the study. 15 patients were treated with Open reduction & internal fixation with volar placed buttress plate and 15 were treated with Closed r eduction & external fixation with „Jess fixator‟ and internal fixation with „k - wire‟ in volar displaced distal radial fractures. Patients were followed up at regular intervals and Anatomical and functional outcomes were evaluated in all the patients. RESUL TS: Patients treated with Open reduction & internal fixation, 8 showed excellent results, 5 good and 2 fair results. Patients treated with closed reduction and external fixation 4 showed excellent results, 5 good, 4 fair and 2 showed poor results. CONCLUSI ON: O.R.I.F is generally preferred modality gives better results in terms of functional recovery and decrease morbidity to patient

  12. The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene.

    Science.gov (United States)

    Kotomura, Naoe; Harada, Nobuhiro; Ishihara, Satoru

    2015-01-01

    The human CYP19 gene encodes aromatase, which converts androgens to estrogens. CYP19 mRNA variants are transcribed mainly from three promoters. Quantitative RT-PCR was used to measure the relative amounts of each of the three transcripts and determine the on/off state of the promoters. While some of the promoters were silent, CYP19 mRNA production differed among the other promoters, whose estimated transcription levels were 0.001% to 0.1% of that of the TUBB control gene. To investigate the structural aspects of chromatin that were responsible for this wide range of activity of the CYP19 promoters, we used a fractionation protocol, designated SEVENS, which sequentially separates densely packed nucleosomes from dispersed nucleosomes. The fractional distribution of each inactive promoter showed a similar pattern to that of the repressed reference loci; the inactive regions were distributed toward lower fractions, in which closed chromatin comprising packed nucleosomes was enriched. In contrast, active CYP19 promoters were raised toward upper fractions, including dispersed nucleosomes in open chromatin. Importantly, these active promoters were moderately enriched in the upper fractions as compared to active reference loci, such as the TUBB promoter; the proportion of open chromatin appeared to be positively correlated to the promoter strength. These results, together with ectopic transcription accompanied by an increase in the proportion of open chromatin in cells treated with an H3K27me inhibitor, indicate that CYP19 mRNA could be transcribed from a promoter in which chromatin is shifted toward an open state in the equilibrium between closed and open chromatin.

  13. Generation of reactive oxygen species in the anterior eye segment. Synergistic codrugs of N-acetylcarnosine lubricant eye drops and mitochondria-targeted antioxidant act as a powerful therapeutic platform for the treatment of cataracts and primary open-angle glaucoma

    Directory of Open Access Journals (Sweden)

    Mark A. Babizhayev

    2016-12-01

    Mitochondrial targeting of compounds with universal types of antioxidant activity represents a promising approach for treating a number of ROS-related ocular diseases of the aging eye and can be implicated in the management of cataracts and primary open-angle glaucoma.

  14. Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating.

    Science.gov (United States)

    Csanády, László; Töröcsik, Beáta

    2014-02-01

    Cystic fibrosis transmembrane conductance regulator (CFTR) is the chloride ion channel mutated in cystic fibrosis (CF) patients. It is an ATP-binding cassette protein, and its resulting cyclic nonequilibrium gating mechanism sets it apart from most other ion channels. The most common CF mutation (ΔF508) impairs folding of CFTR but also channel gating, reducing open probability (Po). This gating defect must be addressed to effectively treat CF. Combining single-channel and macroscopic current measurements in inside-out patches, we show here that the two effects of 5-nitro-2-(3-phenylpropylamino)benzoate (NPPB) on CFTR, pore block and gating stimulation, are independent, suggesting action at distinct sites. Furthermore, detailed kinetic analysis revealed that NPPB potently increases Po, also of ΔF508 CFTR, by affecting the stability of gating transition states. This finding is unexpected, because for most ion channels, which gate at equilibrium, altering transition-state stabilities has no effect on Po; rather, agonists usually stimulate by stabilizing open states. Our results highlight how for CFTR, because of its unique cyclic mechanism, gating transition states determine Po and offer strategic targets for potentiator compounds to achieve maximal efficacy.

  15. Open and closed-loop control of transonic buffet on 3D turbulent wings using fluidic devices

    Science.gov (United States)

    Dandois, Julien; Lepage, Arnaud; Dor, Jean-Bernard; Molton, Pascal; Ternoy, Frédéric; Geeraert, Arnaud; Brunet, Vincent; Coustols, Éric

    2014-06-01

    This paper presents an overview of the work performed recently at ONERA on the control of the buffet phenomenon. This aerodynamic instability induces strong wall pressure fluctuations and as such limits aircraft envelope; consequently, it is interesting to try to delay its onset, in order to enlarge aircraft flight envelop, but also to provide more flexibility during the design phase. Several types of flow control have been investigated, either passive (mechanical vortex generators) or active (fluidic VGs, fluidic trailing-edge device (TED)). It is shown than mechanical and fluidic VGs are able to delay buffet onset in the angle-of-attack domain by suppressing the separation downstream of the shock. The effect of the fluidic TED is different, the separation is not suppressed, but the rear wing loading is increased and consequently the buffet onset is not delayed to higher angles of attack, but only to higher lift coefficient. Then, a closed loop control methodology based on a quasi-static approach is defined and several architectures are tested for various parameters such as the input signal, the objective function or, the tuning of the feedback gain. All closed loop methods are implemented on a dSPACE device calculating in real time the fluidic actuators command from the unsteady pressure sensors data.

  16. Exogenous FGF10 can rescue an eye-open at birth phenotype of Fgf10-null mice by activating activin and TGFalpha-EGFR signaling.

    Science.gov (United States)

    Tao, Hirotaka; Ono, Katsuhiko; Kurose, Hitomi; Noji, Sumihare; Ohuchi, Hideyo

    2006-06-01

    Mutant mice deficient in the fibroblast growth factor 10 (Fgf10) gene exhibit an eye-open phenotype at birth. It has previously been shown that FGF10 has a dual role in proliferation and migration during the early and later stages of eyelid development, respectively. To verify the role of FGF10 during eyelid closure, explant culture of Fgf10-null eyelid anlagen was performed, by which it was examined whether or not exogenous FGF10 could rescue the expression of activin betaB and transforming growth factor alpha, known to be required for eyelid closure. We found that the expression of these genes was markedly induced while that of Shh or Ptch1, Ptch2 was not. We also observed the distribution of filamentous actin (F-actin) after FGF10 application in the mutant eyelid explant, finding that the FGF10 protein induced F-actin accumulation. We further examined filopodia of the eyelid leading edge cells, finding the length of the filopodia was significantly reduced in the mutant. These results verify that FGF10 promotes eyelid closure through activating activin and TGFalpha-EGFR signaling.

  17. Improving the convergence of closed and open path integral molecular dynamics via higher order Trotter factorization schemes

    Science.gov (United States)

    Pérez, Alejandro; Tuckerman, Mark E.

    2011-08-01

    Higher order factorization schemes are developed for path integral molecular dynamics in order to improve the convergence of estimators for physical observables as a function of the Trotter number. The methods are based on the Takahashi-Imada and Susuki decompositions of the Boltzmann operator. The methods introduced improve the averages of the estimators by using the classical forces needed to carry out the dynamics to construct a posteriori weighting factors for standard path integral molecular dynamics. The new approaches are straightforward to implement in existing path integral codes and carry no significant overhead. The Suzuki higher order factorization was also used to improve the end-to-end distance estimator in open path integral molecular dynamics. The new schemes are tested in various model systems, including an ab initio path integral molecular dynamics calculation on the hydrogen molecule and a quantum water model. The proposed algorithms have potential utility for reducing the cost of path integral molecular dynamics calculations of bulk systems.

  18. One-legged standing with eyes closed in physical fitness testing%闭眼单脚站立方法在体质测试中的应用*

    Institute of Scientific and Technical Information of China (English)

    袁金风; 张秋霞; 陆阿明

    2013-01-01

      背景:闭眼单脚站立是反应肌力与平衡能力的测试方法,在中国被作为评价成年人和老年人平衡能力的重要素质指标,以往有大量的测试工作,但深入的研究报道较少。  目的:总结闭眼单脚站立方法的国内外研究现状,分析闭眼单脚站立在体质测试中存在的问题,并展望研究方向。  方法:通过计算机检索CNKI 和Elsevier数据库中相关文献,关键词为“闭眼单脚站立,平衡能力,体质测试”。对资料进行初审,选取符合研究要求的文献。  结果与结论:中国男性闭眼单脚站立评分标准高于女性;测试中出现部分老年人站立时间很短,很难评定其平衡能力;老年人平衡能力明显低于中、青年人,成年人与老年人采用相同的测试方法是否具有科学性;在简单平衡能力测试方法中,闭眼单脚站立的各项指标相关系数较低。鉴于以上原因,闭眼单脚站立作为国民体质平衡能力评价的测试方法尚待进一步研究。%BACKGROUND:One-legged standing with eyes closed is a method to test the muscle strength and the ability of body balance, it is considered to be an important quality indicator for evaluation of adults and elderly balancing capability in our country. A lot of works have been done in many provinces and cities, but there is a lack of in-depth studies. OBJECTIVE:To review the research progress of one-legged standing with eyes closed, to analyze its problem used in the physical fitness test and to prospect the future direction of the related researches. METHODS:A computer-based search on CNKI database and Elsevier database was undertaken to identify the article of balance capacity. The key words were“eyes closed and single legged standing, balance ability, physical fitness test”. Total y articles were searched and checked primarily, and those meeting the criteria were looked up. RESULTS AND CONCLUSION

  19. ACTIVATION OF VASTUS MEDIALIS OBLIQUES AT DIFFERENT KNEE ANGLES IN CLOSED KINETIC CHAIN AND OPEN KINETIC CHAIN POSITION IN SUBJECTS WITH PATELLO FEMORAL PAIN SYNDROME

    Directory of Open Access Journals (Sweden)

    Ujwal Bhattacharya

    2015-06-01

    Full Text Available Background: Patello femoral pain syndrome is one of the most common musculoskeletal disorders and is reported to affect 15% - 33% of an active adult population and 21%-45% of adolescents thereby decreasing the work capacity of an individual. Patello femoral pain syndrome as implicated is due to inappropriate neural control of the quadriceps femoris muscle. Since Vastus medialis muscle is regarded as the dynamic medial stabilizer of patella so it’s important to understand the activation of Vastus Medialis Oblique’s in patients with patello femoral pain syndrome The purpose of this study is to assess the activation of Vastus Medialis Oblique’s at different knee angles between closed kinetic chain position and open kinetic chain position and the information thus gained can be used to design training program aimed at controlling patello femoral joint dysfunction. Methods: Thirty subjects with patello femoral pain syndrome (assessed through history and examination were assigned to two groups. Group A was made to perform open kinetic chain activity(i.e. sitting on high plinth and Group B was made to perform a closed kinetic chain activity(i.e. standing The outcome measure were amplitude and duration. Analyses were performed using independent t-Test. Results: Significant difference was found between the groups for amplitude and duration at varying angles. Amplitude: 0 degree (p=0.004, 60 degrees (p=0.015, 90 degrees (p=0.004. Duration: 0 degree (p=0.007, 60 degrees (p=0.008,90 degrees (p=0.002 Conclusion: Based on the outcome of the study it’s concluded that there is greater activation of Vastus Medialis Oblique’s muscle while performing close kinetic chain activity than in open kinetic chain.

  20. Collagen and glycosaminoglycan profiles in the canine cervix during different stages of the estrous cycle and in open- and closed-cervix pyometra.

    Science.gov (United States)

    Linharattanaruksa, Pichanun; Srisuwatanasagul, Sayamon; Ponglowhapan, Suppawiwat; Khalid, Muhammad; Chatdarong, Kaywalee

    2014-03-01

    The extracellular matrix of the cervix that comprises collagen, elastin, proteoglycans and glycosaminoglycans (GAGs) is thought to have an essential role in cervical relaxation. This study investigated the proportion of collagen and smooth muscle as well as the GAGs in cervices obtained from healthy bitches at different stages of the estrous cycle and bitches with open- and closed-cervix pyometra. Cervices were collected after ovariohysterectomy. The proportion of collagen to smooth muscle was determined using Masson's trichrome staining. Alcian blue staining was used to evaluate the relative distribution of cervical GAGs. The proportion of cervical collagen relative to smooth muscle was higher at estrus compared to anestrus (P≤0.05). It was also higher (P≤0.05) in bitches with open- compared to those with closed-cervix pyometra. Overall, hyaluronan (HA) was the predominant GAG in the canine cervix. In the luminal epithelium, the staining intensity for HA was stronger in estrus than in anestrus (P≤0.05), but not in diestrus (P>0.05). On the contrary, the intensity for the combined keratan sulfate (KS) and heparan sulfate (HS) was stronger in anestrus than in estrus and diestrus (P≤0.05). In bitches with pyometra, the staining intensity of the stroma for KS and HS was weaker in open- compared to closed-cervix pyometra (P≤0.05). Collectively, the different profiles of collagen and GAG suggest that the metabolism of both collagen and GAGs in the canine cervix is associated with hormonal statuses during the estrous cycle and cervical patency of bitches with pathological uterine conditions, such as pyometra.

  1. Multiscale modeling of the active site of [Fe] hydrogenase: the H₂ binding site in open and closed protein conformations.

    Science.gov (United States)

    Hedegård, Erik Donovan; Kongsted, Jacob; Ryde, Ulf

    2015-05-18

    A series of QM/MM optimizations of the full protein of [Fe] hydrogenase were performed. The FeGP cofactor has been optimized in the water-bound resting state (1), with a side-on bound dihydrogen (2), or as a hydride intermediate (3). For inclusion of H4MPT in the closed structure, advanced multiscale modeling appears to be necessary, especially to obtain reliable distances between CH-H4MPT(+) and the dihydrogen (H2) or hydride (H(-)) ligand in the FeGP cofactor. Inclusion of the full protein is further important for the relative energies of the two intermediates 2 and 3. We finally find that hydride transfer from 3 has a significantly higher barrier than found in previous studies neglecting the full protein environment.

  2. Simulation of Open-loop Plasma Vertical Movement Response in Damavand Tokamak Using Closed-loop Subspace System Identification

    CERN Document Server

    Farahania, N Darestani

    2015-01-01

    A formulation of a multi-input single-output closed-loop subspace system identification method is employed for the purpose of obtaining control-relevant model of the vacuum-plasma response in Damavand tokamak. Such a model is particularly well suited for robust controller design. The accuracy of the estimate of the plant dynamics is estimated by different experiments. The method described in this paper is a worst-case identification technique, in that it aims to minimize the error between the identified model and the true plant. The identified model fitness around defined operating point is more than 90% and with comparison by physical-based model it has better root mean square measure of the goodness of the fit.

  3. Retraction: Open and closed conformations reveal induced fit movements in butyrate kinase 2 activation. J. Diao, Y. D. Ma, and M. S. Hasson.

    Science.gov (United States)

    2012-06-01

    The following article from Proteins: Structure, Function, and Bioinformatics, "Open and closed conformations reveal induced fit movements in butyrate kinase 2 activation," by Jiasheng Diao, Yunglin D. Ma, and Miriam S. Hasson, published online on 21 October 2010 in Wiley Online Library (onlinelibrary.wiley.com), has been retracted by agreement between the journal Editor in Chief, Bertrand Garcia-Moreno, and Wiley Periodicals. The retraction has been agreed because it was established by internal investigation performed by Purdue University that the authors of this article are not the owners of the data and have no right to publication.

  4. Crystal structures of wild-type Trichoderma reesei Cel7A catalytic domain in open and closed states

    Energy Technology Data Exchange (ETDEWEB)

    Bodenheimer, Annette M. [Molecular and Structural Biochemistry Department, North Carolina State University, Raleigh NC USA; Neutron Sciences Directorate, Oak Ridge National Laboratory, TN USA; Meilleur, Flora [Molecular and Structural Biochemistry Department, North Carolina State University, Raleigh NC USA; Neutron Sciences Directorate, Oak Ridge National Laboratory, TN USA

    2016-11-07

    Trichoderma reesei Cel7A efficiently hydrolyses cellulose. We report here the crystallographic structures of the wild-type TrCel7A catalytic domain (CD) in an open state and, for the first time, in a closed state. Molecular dynamics (MD) simulations indicate that the loops along the CD tunnel move in concerted motions. Together, the crystallographic and MD data suggest that the CD cycles between the tense and relaxed forms that are characteristic of work producing enzymes. Analysis of the interactions formed by R251 provides a structural rationale for the concurrent decrease in product inhibition and catalytic efficiency measured for product-binding site mutants.

  5. Evidence for {open_quotes}magnetic rotation{close_quotes} in nuclei: New results on the M1-bands of {sup 198,199}Pb

    Energy Technology Data Exchange (ETDEWEB)

    Clark, R.M. [Lawrence Berkeley National Lab., CA (United States)

    1996-12-31

    Lifetimes of states in four of the M1-bands in {sup 198,199}Pb have been determined through a Doppler Shift Attenuation Method measurement performed using the Gammasphere array. The deduced B(M1) values, which are a sensitive probe of the underlying mechanism for generating these sequences, show remarkable agreement with Tilted Axis Cranking (TAC) calculations. Evidence is also presented for the possible termination of the bands. The results represent clear evidence for a new concept in nuclear excitations: {open_quote}magnetic rotation{close_quote}.

  6. Comparative study of occurrence of depression in the third age in closed and open structures of elderly care according to the Hamilton depression scale

    Directory of Open Access Journals (Sweden)

    Georgia Zintrou

    2014-04-01

    Full Text Available Depression is a serious mental disorder that is a leading cause of morbidity in the elderly and affects the daily lives of the elderly leading to the marginalization and stigmatization. Purpose: The purpose of this study was to investigate the prevalence of depression in the elderly, both in the community and in closed structures and identify possible differences between these two groups. Material and Method: The studied population consisted of 200 elderly people. One hundred of them came from closed structure care (nursing home and the remaining 100 by Open Care Centres (KAPI. For data collection, a specially designed questionnaire that included demographic data, information about their health and their daily habits and Depression Scale Hamilton, were used. Results: The majority of the sample (50.5% was men. Depressive symptomatology was showed by 44% (31% mild and 13% moderate. The men of the nursing home had greater depression than men of KAPI and showed a greater percentage of women (27.3 % mild and 12.1 % moderate, with women of the nursing home outweighing the percentages of those in KAPI. Depressive symptomatology exhibited by widowers, people with multiple pathology and those who did not exercise, with rates of 61.5%, 34.6% and 73.1% respectively. Big difference appeared between closed and open structure, where the elderly in nursing home seemed to show greater depression by 53%, versus 35% of those in KAPI. Conclusions: Gender, marital status, presence of pathology, exercise and living in closed structures of care, seem to influence the occurrence of depression in the elderly.

  7. The location of the open-closed magnetic field line boundary in the dawn sector auroral ionosphere

    Directory of Open Access Journals (Sweden)

    J. A. Wild

    2004-11-01

    Full Text Available As a measure of the degree of coupling between the solar wind-magnetosphere-ionosphere systems, the rate at which the size of the polar cap (the region corresponding to ionospheric termini of open magnetic flux tubes varies is of prime importance. However, a reliable technique by which the extent of the polar cap might be routinely monitored has yet to be developed. Current techniques provide particularly ambiguous indications of the polar cap boundary in the dawn sector. We present a case study of space- and ground-based observations of the dawn-sector auroral zone and attempt to determine the location of the polar cap boundary using multi-wavelength observations of the ultraviolet aurora (made by the IMAGE FUV imager, precipitating particle measurements (recorded by the FAST, DMSP, and Cluster 1 and 3 satellites, and SuperDARN HF radar observations of the ionospheric Doppler spectral width boundary. We conclude that in the dawn sector, during the interval presented, neither the poleward edge of the wideband auroral UV emission (140-180nm nor the Doppler spectral width boundary were trustworthy indicators of the polar cap boundary location, while narrow band UV emissions in the range 130-140nm appear to be much more reliable.

  8. Eye Injuries

    Science.gov (United States)

    The structure of your face helps protect your eyes from injury. Still, injuries can damage your eye, sometimes severely enough that you could lose your vision. Most eye injuries are preventable. If you play sports or ...

  9. Eye Wear

    Science.gov (United States)

    Eye wear protects or corrects your vision. Examples are Sunglasses Safety goggles Glasses (also called eyeglasses) Contact ... jobs and some sports carry a risk of eye injury. Thousands of children and adults get eye ...

  10. Eye Cancer

    Science.gov (United States)

    Cancer of the eye is uncommon. It can affect the outer parts of the eye, such as the eyelid, which are made up ... adults are melanoma and lymphoma. The most common eye cancer in children is retinoblastoma, which starts in ...

  11. Eye Diseases

    Science.gov (United States)

    ... the back of the eye Macular degeneration - a disease that destroys sharp, central vision Diabetic eye problems ... defense is to have regular checkups, because eye diseases do not always have symptoms. Early detection and ...

  12. Comparative evaluation of microleakage in Class II restorations using open vs. closed centripetal build-up techniques with different lining materials

    Directory of Open Access Journals (Sweden)

    Shefali Sawani

    2014-01-01

    Full Text Available Background: Evaluation of microleakage is important for assessing the success of new restorative materials and methods. Aim and Objectives: Comparative evaluation of microleakage in Class II restorations using open vs. closed centripetal build-up techniques with different lining materials. Materials and Methods: Standardized mesi-occlusal (MO and distoocclusal (DO Class II tooth preparations were preparedon 53 molars and samples were randomly divided into six experimental groups and one control group for restorations. Group 1: Open-Sandwich technique (OST with flowable composite at the gingival seat. Group 2: OST with resin-modified glass ionomer cement (RMGIC at the gingival seat. Group 3: Closed-Sandwich technique (CST with flowable composite at the pulpal floor and axial wall. Group 4: CST with RMGIC at the pulpal floor and axial wall. Group 5: OST with flowable composite at the pulpal floor, axial wall, and gingival seat. Group 6: OST with RMGIC at the pulpal floor, axial wall, and gingival seat. Group 7: Control - no lining material, centripetal technique only. After restorations and thermocycling, apices were sealed and samples were immersed in 0.5% basic fuchsin dye. Sectioning was followed by stereomicroscopic evaluation. Results: Results were analyzed using Post Hoc Bonferroni test (statistics is not a form of tabulation. Cervical scores of control were more than the exprimental groups (P 0.05. Conclusion: Class II composite restorations with centripetal build-up alone or when placed with CST reduces the cervical microleakage when compared to OST.

  13. Mitochondrial D-loop {open_quotes}signatures{close_quotes} produced by low-stringency single specific primer PCR constitute a simple comparative human identity test

    Energy Technology Data Exchange (ETDEWEB)

    Barreto, G.; Vago, A.R.; Pena, S.D.J. [and others

    1996-03-01

    We have developed a technique called {open_quotes}LSSP-PCR{close_quotes} (low-stringency single specific primer PCR) that detects single or multiple mutations in DNA. A purified DNA fragment is submitted to PCR by using a single primer specific for one of the extremities of the fragment, under conditions of very low stringency. The primer hybridizes specifically to its complementary extremity and nonspecifically to multiple sites within the fragment, in a sequence-dependent manner. A complex set of reaction products is thus created that, when separated by electrophoresis, constitutes a unique {open_quotes}gene signature.{close_quotes} We here report the application of LSSP-PCR to the detection of sequence variation in the control (D-loop) region of human mtDNA, which is known to differ significantly between unrelated individuals. We prepared human DNA samples from blood and amplified a 1,024-bp portion of the mtDNA control region, using primers L15996 and H408. The amplified mtDNA fragments were then reamplified under LSSP-PCR conditions by using L15996 or H408 as drivers to produce complex signatures that always differed between unrelated individuals and yet were highly reproducible. In contrast, all mother-child pairs tested were identical, as expected from the matrilineal inheritance of mtDNA. Thus, the use of LSSP-PCR to produce D-loop signatures constitutes a powerful new technique for mtDNA-based comparative identity testing. 18 refs., 7 figs.

  14. A science-based approach to understanding waste form durability in open and closed nuclear fuel cycles

    Science.gov (United States)

    Peters, M. T.; Ewing, R. C.

    2007-05-01

    There are two compelling reasons for understanding source term and near-field processes in a radioactive waste geologic repository. First, almost all of the radioactivity is initially in the waste form, mainly in the spent nuclear fuel (SNF) or nuclear waste glass. Second, over long periods, after the engineered barriers are degraded, the waste form is a primary control on the release of radioactivity. Thus, it is essential to know the physical and chemical state of the waste form after hundreds of thousands of years. The United States Department of Energy's Yucca Mountain Repository Program has initiated a long-term program to develop a basic understanding of the fundamental mechanisms of radionuclide release and a quantification of the release as repository conditions evolve over time. Specifically, the research program addresses four critical areas: (a) SNF dissolution mechanisms and rates; (b) formation and properties of U6+-secondary phases; (c) waste form-waste package interactions in the near-field; and (d) integration of in-package chemical and physical processes. The ultimate goal is to integrate the scientific results into a larger scale model of source term and near-field processes. This integrated model will be used to provide a basis for understanding the behaviour of the source term over long time periods (greater than 105 years). Such a fundamental and integrated experimental and modelling approach to source term processes can also be readily applied to development of advanced waste forms as part of a closed nuclear fuel cycle. Specifically, a fundamental understanding of candidate waste form materials stability in high temperature/high radiation environments and near-field geochemical/hydrologic processes could enable development of advanced waste forms 'tailored' to specific geologic settings.

  15. A comparison of linear speed, closed-skill agility, and open-skill agility qualities between backcourt and frontcourt adult semiprofessional male basketball players.

    Science.gov (United States)

    Scanlan, Aaron T; Tucker, Patrick S; Dalbo, Vincent J

    2014-05-01

    The measurement of fitness qualities relevant to playing position is necessary to inform basketball coaching and conditioning staff of role-related differences in playing groups. To date, sprinting and agility performance have not been compared between playing positions in adult male basketball players. Therefore, the purpose of this study was to describe and compare linear speed, closed-skill agility, and open-skill agility qualities between backcourt (point guard and shooting guard positions) and frontcourt (small forward, power forward, and center positions) semiprofessional basketball players. Six backcourt (mean ± SD: age, 24.3 ± 7.9 years; stature, 183.4 ± 4.0 cm; body mass, 85.5 ± 12.3 kg; VO2max, 51.9 ± 4.8 ml·kg(-1)·min(-1)) and 6 frontcourt (mean ± SD: age, 27.5 ± 5.5 years; stature, 194.4 ± 7.1 cm; body mass, 109.4 ± 8.8 kg; VO2max, 47.1 ± 5.0 ml·kg(-1)·min(-1)) adult male basketball players completed 20-m sprint, closed-skill agility, and open-skill agility performance tests. Magnitude-based inferences revealed that backcourt players (5 m, 1.048 ± 0.027 seconds; 10 m, 1.778 ± 0.048 seconds; 20 m, 3.075 ± 0.121 seconds) possessed likely quicker linear sprint times than frontcourt players (5 m, 1.095 ± 0.085 seconds; 10 m, 1.872 ± 0.127 seconds; 20 m, 3.242 ± 0.221 seconds). Conversely, frontcourt players (1.665 ± 0.096 seconds) held possible superior closed-skill agility performance than backcourt players (1.613 ± 0.111 seconds). In addition, unclear positional differences were apparent for open-skill agility qualities. These findings indicate that linear speed and change of direction speed might be differently developed across playing positions. Furthermore, position-related functions might similarly depend on the aspects of open-skill agility performance across backcourt and frontcourt players. Basketball coaching and conditioning staff should consider the development of position-targeted training drills to improve speed, agility

  16. Comparison of open and closed U-Pu equilibrium fuel cycles for Generation-IV fast reactors with the EQL3D procedure

    Energy Technology Data Exchange (ETDEWEB)

    Krepel, Jiri, E-mail: Jiri.Krepel@psi.ch [Laboratory for Reactor Physics and Systems Behaviour, Paul Scherrer Institut, 5232 Villigen PSI (Switzerland); Pelloni, Sandro; Mikityuk, Konstantin [Laboratory for Reactor Physics and Systems Behaviour, Paul Scherrer Institut, 5232 Villigen PSI (Switzerland)

    2012-09-15

    Highlights: Black-Right-Pointing-Pointer We analyze open and closed fuel cycle of GFR, SFR, and LFR cores by means of ERANOS based EQL3D procedure. Black-Right-Pointing-Pointer Equilibrium of open and closed fuel cycles were compared in terms of their performance and safety parameters. Black-Right-Pointing-Pointer All three cores act in equilibrium closed cycle as iso-breeder and have similar fuel composition. Black-Right-Pointing-Pointer In spite of the same fuel composition the Dopper constants and void reactivities strongly differ between the cores. Black-Right-Pointing-Pointer All three systems seem capable, from neutronics point of view, for the fuel cycle closure. - Abstract: The advanced fast reactors of the fourth generation should enable an indirect burning of poorly fissile {sup 238}U through {sup 239}Pu breeding and recycling of the actinides from their own spent fuel. The recycling or actually the fuel cycle closure can significantly reduce the amount of long-lived radioactive waste and the {sup 238}U burning can multiply the sustainability of the uranium fueled reactors. Regular periodic operation with the fuel recycling converges to an equilibrium cycle. To enable its simulation a numerical tool named equilibrium fuel cycle procedure for fast reactors (EQL3D) was developed in the FAST group of LRS at Paul Scherrer Institut. The procedure is based on the ERANOS code and can be used to yield the description of two basic situations: the equilibrium of an open fuel cycle and the equilibrium of a closed fuel cycle. The goals of the present study are (i) to apply EQL3D to the Gas-cooled Fast Reactor (GFR), Sodium-cooled Fast Reactor (SFR), and Lead-cooled Fast Reactor (LFR), (ii) to simulate and confirm the GFR, SFR, and LFR neutronics capability for closed fuel cycle, and (iii) to evaluate and compare the equilibrium cycle safety and performance parameters. The EQL3D capability enables to characterize the equilibrium cycle for complex reloading patterns

  17. Hygienization and control of Diplodia seriata fungus in vine pruning waste composting and its seasonal variability in open and closed systems.

    Science.gov (United States)

    Matei, Petruta M; Sánchez-Báscones, Mercedes; Bravo-Sánchez, Carmen T; Martín-Ramos, Pablo; Martín-Villullas, M Teresa; García-González, M Cruz; Hernández-Navarro, Salvador; Navas-Gracia, Luis M; Martín-Gil, Jesús

    2016-12-01

    After the ban on sodium arsenite, waste management alternatives to the prevalent burning method, such as the hygienization and biodegradation in solid phase by composting, are required for the pruned material from grapevines affected by various fungi. In this work the dynamics of a fungus associated with vine decay (Diplodia seriata) during the composting process of a mixture of laying hen manure and vine pruning waste (2:1w/w) have been investigated in an open pile and a discontinuous closed biodigester. Through the optimization of the various physical-chemical parameters, hygienization of the infected waste materials was attained, yielding class-A organo-mineral fertilizers. Nevertheless, important differences in the efficiency of each system were observed: whereas in the open pile it took 10days to control D. seriata and 35 additional composting days to achieve full inactivation, in the discontinuous biodigester the fungus was entirely inactivated within the first 3-7days. Finally, the impact of seasonal variability was assessed and summer temperatures shown to have greater significance in the open pile.

  18. Closed headpiece of integrin [alpah]IIb[beta]3 and its complex with an [alpha]IIb[beta]3-specific antagonist that does not induce opening

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Jieqing; Zhu, Jianghai; Negri, Ana; Provasi, Davide; Filizola, Marta; Coller, Barry S.; Springer, Timothy A. (Sinai); (Rockefeller); (CH-Boston)

    2011-08-24

    The platelet integrin {alpha}{sub IIb}{beta}{sub 3} is essential for hemostasis and thrombosis through its binding of adhesive plasma proteins. We have determined crystal structures of the {alpha}{sub IIb}{beta}{sub 3} headpiece in the absence of ligand and after soaking in RUC-1, a novel small molecule antagonist. In the absence of ligand, the {alpha}{sub IIb}{beta}{sub 3} headpiece is in a closed conformation, distinct from the open conformation visualized in presence of Arg-Gly-Asp (RGD) antagonists. In contrast to RGD antagonists, RUC-1 binds only to the {alpha}{sub IIb} subunit. Molecular dynamics revealed nearly identical binding. Two species-specific residues, {alpha}{sub IIb} Y190 and {alpha}{sub aIIb} D232, in the RUC-1 binding site were confirmed as important by mutagenesis. In sharp contrast to RGD-based antagonists, RUC-1 did not induce {alpha}{sub IIb}{beta}{sub 3} to adopt an open conformation, as determined by gel filtration and dynamic light scattering. These studies provide insights into the factors that regulate integrin headpiece opening, and demonstrate the molecular basis for a novel mechanism of integrin antagonism.

  19. Comparative CO2 flux measurements by eddy covariance technique using open- and closed-path gas analysers over the equatorial Pacific Ocean

    Directory of Open Access Journals (Sweden)

    Fumiyoshi Kondo

    2012-04-01

    Full Text Available Direct comparison of air–sea CO2 fluxes by open-path eddy covariance (OPEC and closed-path eddy covariance (CPEC techniques was carried out over the equatorial Pacific Ocean. Previous studies over oceans have shown that the CO2 flux by OPEC was larger than the bulk CO2 flux using the gas transfer velocity estimated by the mass balance technique, while the CO2 flux by CPEC agreed with the bulk CO2 flux. We investigated a traditional conflict between the CO2 flux by the eddy covariance technique and the bulk CO2 flux, and whether the CO2 fluctuation attenuated using the closed-path analyser can be measured with sufficient time responses to resolve small CO2 flux over oceans. Our results showed that the closed-path analyser using a short sampling tube and a high volume air pump can be used to measure the small CO2 fluctuation over the ocean. Further, the underestimated CO2 flux by CPEC due to the attenuated fluctuation can be corrected by the bandpass covariance method; its contribution was almost identical to that of H2O flux. The CO2 flux by CPEC agreed with the total CO2 flux by OPEC with density correction; however, both of them are one order of magnitude larger than the bulk CO2 flux.

  20. Designs for the self-assembly of open and closed macromolecular structures and a molecular switch using DNA methyltransferases to order proteins on nucleic acid scaffolds

    Science.gov (United States)

    Smith, Steven S.

    2002-06-01

    The methyltransferase-directed addressing of fusion proteins to DNA scaffolds offers an approach to the construction of protein/nucleic acid biostructures with potential in a variety of applications. The technology is currently only limited by the yield of high occupancy structures. However, current evidence shows that DNA scaffolds that contain three or four targeted proteins can be reliably constructed. This permits a variety of macromolecular designs, several of which are given in this paper. Designs for open and closed two-dimensional and three-dimensional assemblies and a design for a molecular switch are discussed. The closed two-dimensional assembly takes the form of a square, and could find application as a component of other systems including a macromolecular rotaxane. The closed three-dimensional system takes the form of a trigonal bipyramid and could find application as a macromolecular carcerand. The molecular switch could find application as a peptide biosensor. Guidelines for the construction and structural verification of these designs are reported.

  1. A wearable device for measuring eye dynamics in real-world conditions.

    Science.gov (United States)

    Knopp, Simon; Bones, Philip; Weddell, Stephen; Innes, Carrie; Jones, Richard

    2013-01-01

    Drowsiness and lapses of responsiveness have the potential to cause fatalities in many occupations. One subsystem of a prototype device which aims to detect these lapses as they occur is described. A head-mounted camera measures several features of the eye that are known to correlate with drowsiness. The system was tested with eight combinations of eye colour, ambient lighting, and eye glasses to simulate typical real-world input conditions. A task was completed for each set of conditions to simulate a range of eye movement-saccades, tracking, and eye closure. Our image processing software correctly classified 99.3% of video frames as open/closed/partly closed, and the error rate was not affected by the combinations of input conditions. Most errors occurred during eyelid movement. The accuracy of the pupil localisation was also not influenced by input conditions, with the possible exception of one subject's glasses.

  2. Stable tetrabenzo-Chichibabin's hydrocarbons: Tunable ground state and unusual transition between their closed-shell and open-shell resonance forms

    KAUST Repository

    Zeng, Zebing

    2012-09-05

    Stable open-shell polycyclic aromatic hydrocarbons (PAHs) are of fundamental interest due to their unique electronic, optical, and magnetic properties and promising applications in materials sciences. Chichibabin\\'s hydrocarbon as a classical open-shell PAH has been investigated for a long time. However, most of the studies are complicated by their inherent high reactivity. In this work, two new stable benzannulated Chichibabin\\'s hydrocarbons 1-CS and 2-OS were prepared, and their electronic structure and geometry in the ground state were studied by various experiments (steady-state and transient absorption spectra, NMR, electron spin resonance (ESR), superconducting quantum interference device (SQUID), FT Raman, X-ray crystallographic etc.) and density function theory (DFT) calculations. 1-CS and 2-OS exhibited tunable ground states, with a closed-shell quinoidal structure for 1-CS and an open-shell biradical form for 2-OS. Their corresponding excited-state forms 1-OS and 2-CS were also chemically approached and showed different decay processes. The biradical 1-OS displayed an unusually slow decay to the ground state (1-CS) due to a large energy barrier (95 ± 2.5 kJ/mol) arising from severe steric hindrance during the transition from an orthogonal biradical form to a butterfly-like quinoidal form. The quick transition from the quinoidal 2-CS (excited state) to the orthogonal biradicaloid 2-OS (ground state) happened during the attempted synthesis of 2-CS. Compounds 1-CS and 2-OS can be oxidized into stable dications by FeCl 3 and/or concentrated H 2SO 4. The open-shell 2-OS also exhibited a large two-photon absorption (TPA) cross section (760 GM at 1200 nm). © 2012 American Chemical Society.

  3. Efficient Eye Blink Detection Method for disabled-helping domain

    Directory of Open Access Journals (Sweden)

    Assit. Prof. Aree A. Mohammed

    2014-06-01

    Full Text Available In this paper, we present a real time method based on some video and image processing algorithms for eye blink detection. The motivation of this research is the need of disabling who cannot control the calls with human mobile interaction directly without the need of hands. A Haar Cascade Classifier is applied for face and eye detection for getting eye and facial axis information. In addition, the same classifier is used based on Haar- like features to find out the relationship between the eyes and the facial axis for positioning the eyes. An efficient eye tracking method is proposed which uses the position of detected face. Finally, an eye blinking detection based on eyelids state (close or open is used for controlling android mobile phones. The method is used with and without smoothing filter to show the improvement of detection accuracy. The application is used in real time for studying the effect of light and distance between the eyes and the mobile device in order to evaluate the accuracy detection and overall accuracy of the system. Test results show that our proposed method provides a 98% overall accuracy and 100% detection accuracy for a distance of 35 cm and an artificial light.

  4. A review of the ecology and management of temporarily open/closed estuaries in South Africa, with particular emphasis on river flow and mouth state as primary drivers of these systems

    CSIR Research Space (South Africa)

    Taljaard, Susan

    2012-06-01

    Full Text Available Research in South African temporarily open/closed estuaries that includes studies on the hydrodynamics, sediment dynamics, acronutrients, microalgae, macrophytes, zoobenthos, hyperbenthos, zooplankton, ichthyoplankton, fishes and birds is used as a...

  5. Expanded eggshell procedure combined with closing-opening technique (a modified vertebral column resection) for the treatment of thoracic and thoracolumbar angular kyphosis.

    Science.gov (United States)

    Liu, Xinyu; Yuan, Suomao; Tian, Yonghao; Wang, Lianlei; Zheng, Yanping; Li, Jianmin

    2015-07-01

    The purpose of this study was to determine the efficacy of a modified vertebral column resection for the treatment of thoracolumbar angular kyphosis. A total of 13 patients (8 male, 5 female) with thoracolumbar kyphosis (kyphotic angle > 60°) were included in this study (Group A). There were 3 patients with failure of spinal formation (Type 1 deformity), 6 patients with old thoracic or lumbar compression fracture, and 4 patients with old spinal tuberculosis (including 1 case of T3-5 vertebral malunion). The average preoperative kyphotic angle was 67.3° (range 62°-75°). Each patient underwent an expanded eggshell procedure combined with the closing-opening technique for the treatment of thoracolumbar angular kyphosis. Sixteen patients who were previously treated with a closing-opening wedge osteotomy in the same spine classification group (kyphotic angle > 60°) were used as a control group (Group B). In Group A, the average (± SD) operative time was 400 ± 60 minutes, and the average blood loss was 960 ± 120 ml. There were no surgery-related complications observed during or after the operations. The average local kyphotic angle was 20.3° (range 18°-24.5°), and the average correction rate was 68.7%. In Group B, the average operative time was 470 ± 90 minutes, and the average blood loss was 2600 ± 1600 ml (range 1200-8200 ml). There were segmental vessels and spinal canal venous plexus injury in 1 case, spinal cord injury in 1 case, dural tearing in 2 cases, pleural rupture in 2 cases, and hemothorax and pneumothorax in 1 case. Each patient had more than 2 years of follow-up. At the latest follow-up examination, the average regional kyphotic angle was 19.9° ± 9.1° (range 19°-34°), and there was no significant loss of correction (p > 0.05). There was greater blood loss and a higher complication rate in Group B than in Group A (p < 0.05). An expanded eggshell procedure combined with the closing-opening technique for the treatment of thoracolumbar

  6. With eyes wide open: a revision of species within and closely related to the Pocillopora damicornis species complex (Scleractinia; Pocilloporidae) using morphology and genetics

    National Research Council Canada - National Science Library

    Schmidt‐Roach, Sebastian; Miller, Karen J; Lundgren, Petra; Andreakis, Nikos

    2014-01-01

    ...‐morphology, therefore reflecting species‐level differentiation. However, high levels of gross morphological plasticity and shared morphological characteristics mask clear separation for some groups. Fine...

  7. Translocation 4p;21q identified by FISH in a case previously described as {open_quotes}presumptive monosomy 21{close_quotes}

    Energy Technology Data Exchange (ETDEWEB)

    Yao, Xiu-Lan; Jenkins, E.C. [New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY (United States)

    1994-10-01

    Recently, Lopez-Pajares et al. (1993) reported identification of a translocation between the short arm of a chromosome 5 and the long arm of a chromosome 21 in a patient who was thought to be monosomy 21. This study is the first application of a chromosome 21 painting probe, pBS-21, and fluorescent in situ chromosome hybridization (FISH) to revise an earlier diagnosis of monosomy 21. We have now restudied skin fibroblast cultures, GM00137B, that are still available from another patient previously described as {open_quotes}presumptive monosomy 21{close_quotes} and have found that this case also has a translocation involving chromosomes 21 and 4. The authors urge that all previous cases of what appeared to be monosomy 21 should be re-examined with FISH to confirm or revise the original diagnosis so that genetic counseling of the family may be updated. 3 refs., 3 figs.

  8. Modified Projective Synchronization between Different Fractional-Order Systems Based on Open-Plus-Closed-Loop Control and Its Application in Image Encryption

    Directory of Open Access Journals (Sweden)

    Hongjuan Liu

    2014-01-01

    Full Text Available A new general and systematic coupling scheme is developed to achieve the modified projective synchronization (MPS of different fractional-order systems under parameter mismatch via the Open-Plus-Closed-Loop (OPCL control. Based on the stability theorem of linear fractional-order systems, some sufficient conditions for MPS are proposed. Two groups of numerical simulations on the incommensurate fraction-order system and commensurate fraction-order system are presented to justify the theoretical analysis. Due to the unpredictability of the scale factors and the use of fractional-order systems, the chaotic data from the MPS is selected to encrypt a plain image to obtain higher security. Simulation results show that our method is efficient with a large key space, high sensitivity to encryption keys, resistance to attack of differential attacks, and statistical analysis.

  9. Multiple recurrence of trisomy 21 in two Bedouin families: Parental gonadal mosaicism or {open_quotes}aneuploidy{close_quotes} gene effect?

    Energy Technology Data Exchange (ETDEWEB)

    Farag, T.I.; Murthy, D.S.K. [Kuwait Medical Genetics Centre, Sulibikhat (Kuwait)

    1994-09-01

    Two unrelated multiplex Down syndrome families is reported in Kuwait among the highly inbred population with Bedouin ancestors. Each family showed recurrent aneuploidies in three sibs with regular trisomy 21. Recurrent regular trisomy 21 in two or more siblings of healthy, normal parents (parental age <35 years) occurs rarely. Several possible etiological factors for recurrent aneuploidy have been suggested. The recurrence risks for regular trisomy 21 based on livebirth and prenatal diagnosis data were estimated at 1% - 2% for young women. However, there are no estimates for multiple recurrence of regular trisomy 21 in the young parents (<35 years). Clustering of trisomy 21 and trisomy 18 have been observed in Bedouin tribal population. The possibility of parental gonadal mosaicism and/or a possibility of an {open_quotes}aneuploidy gene{close_quotes} effect should be considered in practical genetic counselling of families with multiple recurrence of trisomy 21.

  10. Post-pneumonectomy broncho-pleural fistula successfully closed by open-window thoracostomy associated with V.A.C. therapy.

    Science.gov (United States)

    Laperuta, Paolo; Napolitano, Filomena; Vatrella, Alessandro; Di Crescenzo, Rosa Maria; Cortese, Antonio; Di Crescenzo, Vincenzo

    2014-01-01

    Broncho-pleural fistula (BPF), is a dramatic complication that may occur after lung resection. The treatment is challenging due to its high rate of morbidity and mortality. Herein, a case of BPF associated with empyema, occurred in an elderly patient who had undergone to left pneumonectomy for non-small cell lung cancer (NSCLC), is reported. After various treatments including chest drainage and endoscopic procedures, BPF was successfully closed by open-window thoracotomy associated with vacuum assisted closure (V.A.C.) device therapy. The authors conclude that V.A.C. is a convenient and safe measure in the management of empyema with BPF. Moreover, in similar clinical contexts, V.A.C. may be the only option available that may assure the survival of the patient and the avoiding any later-phases of residual cavity. Copyright © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  11. The potential value of employing a RLV-based {open_quotes}pop-up{close_quotes} trajectory approach for space access

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, E.; OLeary, R. [W. J. Schafer Associates 2000 Randolph Rd, SE, Ste. 205 Albuquerque, New Mexico87106 (United States)

    1997-01-01

    This paper presents the potential benefits of employing useful upper stages with planned reusable launch vehicle systems to increase payload performance to various earth orbits. It highlights these benefits through performance analysis on a generic vehicle/upper-stage combination (basing all estimates on realistic technology availability). A nominal 34,019 kg [75,000 lbm] dry mass RLV capable of orbiting 454 kg into a polar orbit by itself (SSTO) would be capable of orbiting 9500{endash}10,000 kg into a polar orbit using a nominal upper stage released from a suborbital trajectory. The paper also emphasizes the technical and operational issues associated with actually executing a {open_quotes}pop-up{close_quotes} trajectory launch and deployment. {copyright} {ital 1997 American Institute of Physics.}

  12. What type of computer-assisted exercise supports young less skilled spellers in resolving problems in open and closed syllable words?

    Science.gov (United States)

    Hilte, Maartje; Reitsma, Pieter

    2008-12-01

    Dutch bisyllabic words containing open and closed syllables are particularly difficult to spell for children. What kind of support in spelling exercises improves the spelling of these words the most? Two extensions of a commonly used dictation exercise were tested: less skilled spellers in grade 2 (n = 50; 7 years and 10 months) either received explicit syllabic segmentation cues or received spelling cues by means of a visual preview. Comparisons between pre-, post-, and retention tests of spelling skill showed that extra syllabic cues did not show a significant improvement beyond normal spelling dictation and that visual preview was most effective as compared to the other types of training. The findings suggest that word-specific knowledge can effectively be improved by exposure to the correct letter pattern during exercises in spelling and seems to result in lasting improvement of word-specific orthographic representations, at least for 5 weeks.

  13. Orientations and proximities of the extracellular ends of transmembrane helices S0 and S4 in open and closed BK potassium channels.

    Directory of Open Access Journals (Sweden)

    Xiaowei Niu

    Full Text Available The large-conductance potassium channel (BK α subunit contains a transmembrane (TM helix S0 preceding the canonical TM helices S1 through S6. S0 lies between S4 and the TM2 helix of the regulatory β1 subunit. Pairs of Cys were substituted in the first helical turns in the membrane of BK α S0 and S4 and in β1 TM2. One such pair, W22C in S0 and W203C in S4, was 95% crosslinked endogenously. Under voltage-clamp conditions in outside-out patches, this crosslink was reduced by DTT and reoxidized by a membrane-impermeant bis-quaternary ammonium derivative of diamide. The rate constants for this reoxidation were not significantly different in the open and closed states of the channel. Thus, these two residues are approximately equally close in the two states. In addition, 90% crosslinking of a second pair, R20C in S0 and W203C in S4, had no effect on the V50 for opening. Taken together, these findings indicate that separation between residues at the extracellular ends of S0 and S4 is not required for voltage-sensor activation. On the contrary, even though W22C and W203C were equally likely to form a disulfide in the activated and deactivated states, relative immobilization by crosslinking of these two residues favored the activated state. Furthermore, the efficiency of recrosslinking of W22C and W203C on the cell surface was greater in the presence of the β1 subunit than in its absence, consistent with β1 acting through S0 to stabilize its immobilization relative to α S4.

  14. Effectiveness of MIS technique as a treatment modality for open intra-articular calcaneal fractures: A prospective evaluation with matched closed fractures treated by conventional technique.

    Science.gov (United States)

    Dhillon, Mandeep Singh; Gahlot, Nitesh; Satyaprakash, Sambit; Kanojia, Rajendra Kumar

    2015-09-01

    Twenty-five displaced intra-articular calcaneal fractures in 21 patients, aged 15-55 years were included in this study. Sanders' type I fractures, severe crushing or partial amputation, were excluded from the study. Patients were divided into group 1 (open fractures treated by MIS), and group 2 (closed fractures treated by ORIF). Group 1 had 16 and group 2 had 9 cases. Seven of 25 fractures (28%) developed wound related issues postoperatively. One patient (11.1%) in group 2 had wound margin necrosis, while 6 patients (37.5%) in group 1 developed pin tract and/or wound infection. At 1-year follow-up, the mean MFS for group 1 was 79 and mean MFS for group 2 was 84.4 (66.67% were good). The AOFAS score for group 1 was 77.37 and for group 2 was 86.1. The Bohlers' angle was restored in 81.16% cases in group 1 and 88.8% in group 2, while Gissane angle was restored in 68.75% of group 1 cases and 77.79% of group 2 cases. This study shows that acceptable fracture reduction can be obtained and maintained by MIS technique and it can be used as the primary definitive treatment option in open calcaneal fractures. Copyright © 2015 Elsevier Ltd. All rights reserved.

  15. Hospital costs of central line-associated bloodstream infections and cost-effectiveness of closed vs. open infusion containers. The case of Intensive Care Units in Italy

    Directory of Open Access Journals (Sweden)

    Torbica Aleksandra

    2010-05-01

    Full Text Available Abstract Objectives The aim was to evaluate direct health care costs of central line-associated bloodstream infections (CLABSI and to calculate the cost-effectiveness ratio of closed fully collapsible plastic intravenous infusion containers vs. open (glass infusion containers. Methods A two-year, prospective case-control study was undertaken in four intensive care units in an Italian teaching hospital. Patients with CLABSI (cases and patients without CLABSI (controls were matched for admission departments, gender, age, and average severity of illness score. Costs were estimated according to micro-costing approach. In the cost effectiveness analysis, the cost component was assessed as the difference between production costs while effectiveness was measured by CLABSI rate (number of CLABSI per 1000 central line days associated with the two infusion containers. Results A total of 43 cases of CLABSI were compared with 97 matched controls. The mean age of cases and controls was 62.1 and 66.6 years, respectively (p = 0.143; 56% of the cases and 57% of the controls were females (p = 0.922. The mean length of stay of cases and controls was 17.41 and 8.55 days, respectively (p Conclusions CLABSI results in considerable and significant increase in utilization of hospital resources. Use of innovative technologies such as closed infusion containers can significantly reduce the incidence of healthcare acquired infection without posing additional burden on hospital budgets.

  16. [Open and closed laryngeal injuries].

    Science.gov (United States)

    Bartnik, Władysław; Bartnik-Krystalska, Alicja

    2003-01-01

    Treatment and results of 13 laryngeal and trachea traumas have been presented. All patients were operated in 24 hours after the injury. We had good results, only two patients had vocal chord paralysis. After phoniatric rehabilitation they regained good voice.

  17. Relationships between movements of the lower limb joints and the pelvis in open and closed kinematic chains during a gait cycle

    Directory of Open Access Journals (Sweden)

    Svoboda Zdenek

    2016-06-01

    Full Text Available Lots of athletic skills performed during practice or competition are initiated by the legs, where athletes either walk or run prior to executing specific skills. Kinematic chains are used to describe the relationships between body segments and joints during movement. The aim of this study was to determine the relationships between movements of lower limb segments and the pelvis in open and closed kinematic chains while walking. The experimental group consisted of 32 males (age 23.3 ± 2.5 years, body mass 78.1 ± 8.7 kg, body height 182 ± 6 cm. For 3D analysis, an optoelectronic system Vicon MX (7 cameras, frequency 200 Hz was used. Positioning of the segments was determined by the PlugInGait Model. Each participant executed five trials at speeds ranging from 1.38 to 1.52 m·s-1. The relationships between angle variables of the lower limbs and the pelvis in selected gait cycle phases were evaluated using STATISTICA software (version 10.0 and the Spearman correlation. The highest numbers of moderate and large correlations were found at opposite toe off, heel rise and initial contact for the sagittal and transversal planes in comparison to the frontal plane. The closed kinematic chain had a stronger impact on determining the movement pattern. The instructions or interventions focusing on closed kinematic chain alternation are more effective for changes in a movement pattern. The preferred limb initiates kinematics in the direction of propulsion, while the non-preferred limb in internal and external rotation.

  18. The power features of Masseter muscle activity in tension-type and migraine without aura headache during open-close clench cycles

    Directory of Open Access Journals (Sweden)

    Behrouz Alizadeh Savareh

    2017-07-01

    Full Text Available Introduction Different types of headaches and TMJ click influence the masseter muscle activity. The aim of this study was to assess the trend of energy level of the electromyography (EMG activity of the masseter muscle during open-close clench cycles in migraine without aura (MOA and tension-type headache (TTH with or without TMJ click. Methods Twenty-five women with MOA and twenty four women with TTH participated in the study. They matched with 25 healthy subjects, in terms of class of occlusion and prevalence of temporomandibular joint (TMJ with click. The EMG of both masseter muscles were recorded during open-close clench cycles at a rate of 80 cycles per minute for 15 seconds. The mouth opening was restricted to two centimeters by mandibular motion frame. Signal processing steps have been done on the EMG as: noise removing, smoothing, feature extraction, and statistical analyzing. The six statistical parameters of energy computed were mean, Variance, Skewness, Kurtosis, and first and second half energy over all signal energy. Results A three-way ANOVA indicated that during all the cycles, the mean of energy was more and there was a delay in showing the peak of energy in the masseter of the left side with clicked TMJ in MOA group compared to the two other groups, while this pattern occurred inversely in the side with no-clicked TMJ (P < 0.009. The variation of energy was significantly less in MOA group compared to the two other groups in the no-clicked TMJ (P < 0.003. However, the proportion of the first or second part of signal energy to all energy showed that TTH group had less energy in the first part and more energy in the second part in comparison to the two other groups (P < 0.05. Conclusion The study showed different changes in the energy distribution of masseter muscle activity during cycles in MOA and TTH. MOA, in contrast to TTH, had lateralization effect on EMG and interacted with TMJ click.

  19. 智能助老服务机器人开闭环控制%Intelligent Help-age Service Robot Open-closed Loop Control

    Institute of Scientific and Technical Information of China (English)

    赵建伟; 李国晗; 唐兵; 王洪燕

    2015-01-01

    Introduce an intelligent help-age service robot considering its importance in the task of servicing and entertaining the old men. It briefly introduces the overall structure and design of intelligent help-age service robot and the structure and performance characteristics of open and closed loop control system; it does a detailed study on the closed loop control whose core is the PID algorithm, and through the simulation it sets the P, I, D parameters and make intelligent help-age service robot be able to get accurate control. It makes the robot as an experimental object and through many times experimental comparison, the experimental results show that the PID closed loop control system of intelligent help-age service robot can ensure the working accuracy of the robot in complex environment; it is widely used in an occasion whose external environment is complex and accuracy requirement is higher and its help-age service is obviously better than the open loop control system.%针对助老服务机器人在服务以及娱乐老人任务中的重要性,介绍一种智能助老服务机器人.简要介绍智能助老服务机器人的总体结构设计,开、闭环控制系统的结构以及性能特点,详细研究以 PID算法为核心的闭环控制,通过仿真设计P, I, D参数,使智能助老服务机器人能够得到精确控制.并以该机器人为实验对象,进行多次实验对比.实验结果表明:智能助老服务机器人的 PID闭环控制系统能保证机器人在复杂环境下工作的精确性,广泛应用于外界环境复杂、对精度要求较高的场合,其助老服务明显优于开环控制系统.

  20. Oxygen isotope exchange kinetics of mineral pairs in closed and open systems: Applications to problems of hydrothermal alteration of igneous rocks and Precambrian iron formations

    Science.gov (United States)

    Gregory, R.T.; Criss, R.E.; Taylor, H.P.

    1989-01-01

    The systematics of stable-isotope exchange between minerals and fluids are examined in the context of modal mineralogical variations and mass-balance considerations, both in closed and in open systems. On mineral-pair ??18O plots, samples from terranes that have exchanged with large amounts of fluid typically map out steep positively-sloped non-equilibrium arrays. Analytical models are derived to explain these effects; these models allow for different exchange rates between the various minerals and the external fluids, as well as different fluid fluxes. The steep arrays are adequately modelled by calculated isochron lines that involve the whole family of possible exchange trajectories. These isochrons have initially-steep near-vertical positive slopes that rotate toward a 45?? equilibrium slope as the exchange process proceeds to completion. The actual data-point array is thus analogous to the hand of an "isotopic clock" that measures the duration of the hydrothermal episode. The dimensionless ratio of the volumetric fluid flux to the kinetic rate parameter ( u k) determines the shape of each individual exchange trajectory. In a fluid-buffered system ( u k ??? 1), the solutions to the equations: (1) are independent of the mole fractions of the solid phases; (2) correspond to Taylor's open-system water/rock equation; and (3) yield straight-line isochrons that have slopes that approach 1 f, where f is the fraction reacted of the more sluggishly exchanging mineral. The isochrons for this simple exchange model are closely congruent with the isochrons calculated for all of the more complex models, thereby simplifying the application of theory to actual hydrothermal systems in nature. In all of the models an order of magnitude of time (in units of kt) separates steep non-equilibrium arrays (e.g., slope ??? 10) from arrays approaching an equilibrium slope of unity on a ??-?? diagram. Because we know the approximate lifetimes of many hydrothermal systems from geologic and

  1. Ocular health among radiologists in the age of PACS: is it time for our profession to open its eyes to this issue in light of existing European legislation?

    LENUS (Irish Health Repository)

    Halpenny, D

    2012-12-01

    The regular use of visual display units (VDUs) at work has been shown to cause the development of a constellation of symptoms ranging from dry eyes to temporary myopia. European workers who use VDUs are now protected under detailed legislation enacted by the European Union (Directive 90\\/270\\/EEC). The use of picture archiving and communications systems, which are almost ubiquitous in European countries, means that, as a profession, radiologists fall under the remit of this legislation. This paper aims to assess the impact that full implementation of this law would have on a radiologist\\'s practice and to more broadly examine the issue of eye care as an occupational health issue in radiology. The authors conclude that eye care in the setting of regular VDU use among radiologists is an important quality control and occupational health issue. There is a clear legal basis requiring employers to provide regular eye examinations and reporting breaks. In the absence of leadership from employers on this issue individual radiologists have a responsibility to ensure that their work practices reflect the legal situation and minimise the effect of eye strain on their performance.

  2. Ocular health among radiologists in the age of PACS: is it time for our profession to open its eyes to this issue in light of existing European legislation?

    Science.gov (United States)

    Halpenny, D; O'Driscoll, D; Torreggiani, W C

    2012-12-01

    The regular use of visual display units (VDUs) at work has been shown to cause the development of a constellation of symptoms ranging from dry eyes to temporary myopia. European workers who use VDUs are now protected under detailed legislation enacted by the European Union (Directive 90/270/EEC). The use of picture archiving and communications systems, which are almost ubiquitous in European countries, means that, as a profession, radiologists fall under the remit of this legislation. This paper aims to assess the impact that full implementation of this law would have on a radiologist's practice and to more broadly examine the issue of eye care as an occupational health issue in radiology. The authors conclude that eye care in the setting of regular VDU use among radiologists is an important quality control and occupational health issue. There is a clear legal basis requiring employers to provide regular eye examinations and reporting breaks. In the absence of leadership from employers on this issue individual radiologists have a responsibility to ensure that their work practices reflect the legal situation and minimise the effect of eye strain on their performance.

  3. Eye Anatomy

    Science.gov (United States)

    ... News About Us Donate In This Section Eye Anatomy en Español email Send this article to a ... You at Risk For Glaucoma? Childhood Glaucoma Eye Anatomy Five Common Glaucoma Tests Glaucoma Facts and Stats ...

  4. Eye trauma

    African Journals Online (AJOL)

    2011-02-02

    Feb 2, 2011 ... will invariably lead to lid swelling, making the examination far more difficult. ... protect the eye with a pad or shield, give tetanus prophylaxis and refer. ... A study on penetrating eye injuries in South African children found.

  5. Gas-flow optimization studies on brass samples using closed and open types of laser ablation cells in inductively coupled plasma mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Kantor, Tibor, E-mail: kantort@mafi.hu; Kiraly, Edit; Bertalan, Eva; Bartha, Andras

    2012-02-15

    The effect of the carrier gas flow rate on laser ablation inductively coupled mass spectrometry (LA-ICP-MS) signals of brass components (Cu, Zn, and Ni) were studied primarily with the use of a conventional closed ablation cell (UP-213) and with the use of an open ablation cell of our own construction. In the closed ablation cell configuration with the carrier gas flow rate in the range of 0.40-1.3 L min{sup -1} Ar, the MS signals increased significantly (an 8.2-fold increase for a Cu signal), and the Zn/Cu signal ratio increased 3.2 times. To identify the degree of fractionation, the conventional solution sample introduction method was selected as the reference method because it is expected free from fractionation for Cu and Zn. To obtain a theoretical value, calculations were made based on Saha's relationship of ionization, which resulted in fair agreement with the experimental results of the solution method. By comparing the Zn/Cu signal ratios obtained from both the LA and the solution method, a fractionation factor of 2.26 was deduced for these two components. To explain the increased signals described above, the transport efficiency as a function of the carrier gas flow rate was calculated for different particle size fractions based on existing theories. It was demonstrated that the large increase in the signals with carrier gas flow rate is predominantly due to processes taking place in the ablation cell (i.e., neither during the transportation nor in the ICP). The results of the novel fundamental works on aerosol formation under LA conditions were considered and complemented with the application of the Kelvin (Gibbs-Thomson) equation to calculate critical sizes of aerosol particles in the nucleating vapors of Cu, Zn, Ni and Pb elements. It was concluded that the noted increase of signals was due to the intensification of mixing of the expanding vapor-cloud with cold gas when applying an increasing carrier gas flow rate. It was also concluded that the

  6. Measurement of opening and closing angles of aortic valve prostheses in vivo using dual-source computed tomography: Comparison with those of manufacturers' in 10 different types

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Young Joo; Kim, Young Jin; Hong, Yoo Jin; Lee, Hye Jeong; Hur, Jin; Im, Dong Jin; Kim, Yun Jung; Choi, Byoung Wook [Dept. of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, Seoul (Korea, Republic of)

    2015-10-15

    The aims of this study were to compare opening and closing angles of normally functioning mechanical aortic valves measured on dual-source computed tomography (CT) with the manufacturers' values and to compare CT-measured opening angles according to valve function. A total of 140 patients with 10 different types of mechanical aortic valves, who underwent dual-source cardiac CT, were included. Opening and closing angles were measured on CT images. Agreement between angles in normally functioning valves and the manufacturer values was assessed using the interclass coefficient and the Bland-Altman method. CT-measured opening angles were compared between normal functioning valves and suspected dysfunctioning valves. The CT-measured opening angles of normally functioning valves and manufacturers' values showed excellent agreement for seven valve types (intraclass coefficient [ICC], 0.977; 95% confidence interval [CI], 0.962-0.987). The mean differences in opening angles between the CT measurements and the manufacturers' values were 1.2° in seven types of valves, 11.0° in On-X valves, and 15.5° in ATS valves. The manufacturers' closing angles and those measured by CT showed excellent agreement for all valve types (ICC, 0.953; 95% CI, 0.920-0.972). Among valves with suspected dysfunction, those with limitation of motion (LOM) and an increased pressure gradient (PG) had smaller opening angles than those with LOM only (p < 0.05). Dual-source cardiac CT accurately measures opening and closing angles in most types of mechanical aortic valves, compared with the manufacturers' values. Opening angles on CT differ according to the type of valve dysfunction and a decreased opening angle may suggest an elevated PG.

  7. Relationship among eye condition sensitivities,photosensitivity and epileptic syndromes

    Institute of Scientific and Technical Information of China (English)

    YANG Zhi-xian; CAI Xiang; LIU Xiao-yan; QIN Jiong

    2008-01-01

    Background Electroencephalogram(EEG)activity in normal subjects and epileptic patients is often closely related to the eye's status such as eye opened(EO),eye closure(ECL)and eyes closed(EC).ECL is the period immediately after closing of the eyes and only Iasts for Jess than 3 seconds if the eyes remain closed.EC is the pened as long as the eyes are closed.Epileptiform changes on EEG induced by ECL or EC are called the changes of ECL sensitivity(ECLS)or EC sensitivity (ECS).ECLS occurs mainly but not exclusively in photosensitive patients and ECS has been seen rarely in photosensitive patients.This study aimed to investigate the relationships among ECLS,ECS.photosensitivity and epilepsy syndromes in children.Methods EEG records from child patients in the EEG Department of Peking University First Hospital dudng the period of May 2005 to Mav 2007 were examined for the presence of ECLS or ECS.Open-close eye tests and intermittent photic stimulations were carried out during video-EEG monitoring for examining ECLS.ECS and photosensitivity.Results Based on ECLS and ECS on their EEGs,30 patients were divided into ECLS group (16 cases)and ECS group (14 cases).There were more boys than girls in the two groups.The mean age of initial detection of ECLS and ECS was 10 years.and the average onset age of seizures was 9 years.The epilepsy syndromes in the ECLS group included idiopathic photosensitive occipital lobe epilepsy,Panayiotopoulos syndrome,symptomatic occipital lobe epilepsy,juvenile myoclonic epilepsy,juvenile absence epilepsy,eyelid myoclonia with absences,epilepsy with grand mal on awakening and pure photosensitive epilepsy with mainly generalized tonic clonic seizures.Those in the ECS group were iuvenile myoclonic epilepsy,idiopathic photosensitive occipital Iobe epilepsy,Panayiotopoulos syndrome and Gastaut type-idiclpathic children occipital epilepsy.Photosensitivity was detected in 88%of Patients with ECLS and 29%of patients with ECS.Conclusions ECLS and ECS are

  8. Distinct distribution of ectopically expressed histone variants H2A.Bbd and MacroH2A in open and closed chromatin domains.

    Directory of Open Access Journals (Sweden)

    Elena S Ioudinkova

    Full Text Available BACKGROUND: It becomes increasingly evident that nuclesomes are far from being identical to each other. This nucleosome diversity is due partially to the existence of histone variants encoded by separate genes. Among the known histone variants the less characterized are H2A.Bbd and different forms of macroH2A. This is especially true in the case of H2A.Bbd as there are still no commercially available antibodies specific to H2A.Bbd that can be used for chromatin immunoprecipitation (ChIP. METHODS: We have generated HeLa S3 cell lines stably expressing epitope-tagged versions of macroH2A1.1, H2A.Bbd or canonical H2A and analyzed genomic distribution of the tagged histones using ChIP-on-chip technique. RESULTS: The presence of histone H2A variants macroH2A1.1 and H2A.Bbd has been analyzed in the chromatin of several segments of human chromosomes 11, 16 and X that have been chosen for their different gene densities and chromatin status. Chromatin immunoprecipitation (ChIP followed by hybridization with custom NimbleGene genomic microarrays demonstrated that in open chromatin domains containing tissue-specific along with housekeeping genes, the H2A.Bbd variant was preferentially associated with the body of a subset of transcribed genes. The macroH2A1.1 variant was virtually absent from some genes and underrepresented in others. In contrast, in closed chromatin domains which contain only tissue-specific genes inactive in HeLa S3 cells, both macroH2A1.1 and H2A.Bbd histone variants were present and often colocalized. CONCLUSIONS: Genomic distribution of macro H2A and H2A.Bbd does not follow any simple rule and is drastically different in open and closed genomic domains.

  9. Open and closed penalty kick strategies in intermediate soccer player Estrategias abierta y cerrada del penalti en jugadores de nivel intermedio de fútbol

    Directory of Open Access Journals (Sweden)

    J. M. Castillo

    2010-09-01

    Full Text Available

    This study investigates the efficacy of intermediate penalty kickers by comparing the effect of applying an automated WiFi (Wireless Fidelity  system on the field of play to simulate a strategy that takes account of goalkeeper action (open with another for which goalkeeper strategy is irrelevant (closed. Intermediate penalty kickers (n=12 took a pretreatment test of 32 kicks in a “real-play” situation with intermediate goalkeepers (n=3. We established two groups of kickers who underwent 11 treatment sessions using different strategies and then conducted a posttreatment test. The variables we measured were the number of goals scored, whether the direction of the shot was the same or different from the direction of the goalkeeper’s move (DDG, ball speed and the duration of the kicking movement. The results suggest the goalkeepers demonstrated a greater capacity to identify advance cues when faced with CG (closed strategy group kickers and that OG (open strategy group kickers achieved lower ball speeds when modifying the contact surface of the kick.
    Key Words:  penalty kick, anticipation, decision-making, field, training.

     

    Este estudio compara el efecto en la aplicación de un sistema automatizado inalámbrico en el terreno de juego para simular una estrategia que tiene en cuanta la actuación del portero (abierta frente a otra estrategia que la ignora (cerrada sobre la eficacia de lanzadores intermedios de penalti. Lanzadores (n=12 intermedios de penalti realizaron un test pre-tratamiento de 32 tiros en “situación real” con porteros (n=3 intermedios. A continuación se establecieron dos grupos de lanzadores que completaron 11 sesiones de tratamiento utilizando estrategias distintas y por último repitieron un test post-postratamiento. Como variables medimos el número de goles conseguidos, la dirección del chut en la misma o en dirección no

  10. Quantification of surface water and groundwater flows to open- and closed-basin lakes in a headwaters watershed using a descriptive oxygen stable isotope model

    Science.gov (United States)

    Stets, Edward G.; Winter, T. C.; Rosenberry, Donald O.; Striegl, Robert G.

    2010-01-01

    Accurate quantification of hydrologic fluxes in lakes is important to resource management and for placing hydrologic solute flux in an appropriate biogeochemical context. Water stable isotopes can be used to describe water movements, but they are typically only effective in lakes with long water residence times. We developed a descriptive time series model of lake surface water oxygen-18 stable isotope signature (δL) that was equally useful in open- and closed-basin lakes with very different hydrologic residence times. The model was applied to six lakes, including two closed-basin lakes and four lakes arranged in a chain connected by a river, located in a headwaters watershed. Groundwater discharge was calculated by manual optimization, and other hydrologic flows were constrained by measured values including precipitation, evaporation, and streamflow at several stream gages. Modeled and observed δL were highly correlated in all lakes (r = 0.84–0.98), suggesting that the model adequately described δL in these lakes. Average modeled stream discharge at two points along the river, 16,000 and 11,800 m3 d−1, compares favorably with synoptic measurement of stream discharge at these sites, 17,600 and 13,700 m3 d−1, respectively. Water yields in this watershed were much higher, 0.23–0.45 m, than water yields calculated from gaged streamflow in regional rivers, approximately 0.10 m, suggesting that regional groundwater discharge supports water flux through these headwaters lakes. Sensitivity and robustness analyses also emphasized the importance of considering hydrologic residence time when designing a sampling protocol for stable isotope use in lake hydrology studies.

  11. GM130 is a parallel tetramer with a flexible rod-like structure and N-terminally open (Y-shaped) and closed (I-shaped) conformations.

    Science.gov (United States)

    Ishida, Ryuichi; Yamamoto, Akitsugu; Nakayama, Kazuhisa; Sohda, Miwa; Misumi, Yoshio; Yasunaga, Takuo; Nakamura, Nobuhiro

    2015-06-01

    GM130 is a cytoplasmic peripheral membrane protein localized on the cis side of the Golgi apparatus. GM130 is proposed to function as a membrane skeleton, maintaining the structure of the Golgi apparatus, and as a vesicle tether that facilitates vesicle fusion to the Golgi membrane. More than 60% of the GM130 molecule is believed to exist as coiled-coil structures with a probability above 90%, based on its primary amino acid sequence. The predicted coiled-coil region was similar to that of yeast Uso1p and its mammalian homolog, p115, both of which form coiled-coil homodimers. Therefore, GM130 has long been thought to form a homodimer with a rod-like shape. However, our biochemical and electron microscopical analyses revealed that GM130 is a parallel homotetramer with a flexible rod-like structure with I- and Y-shaped conformations. The structure of the N-terminal region may interchange between an open conformation (branched or Y-shaped) and a closed conformation (non-branched or I-shaped), possibly with the help of interacting molecules. This conformational change may alter the oligomeric state of the GM130 molecules and the function of GM130 in the vesicle tethering and the maintenance of the Golgi structure. © 2015 FEBS.

  12. Volume II solicitation package for solicitation no. 522887-5422 {open_quotes}site electrical replacements & substation{close_quotes} subproject: 69 KV substation

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1991-05-03

    This solicitation is for the U.S. Department of Energy under Prime Contract No. DE-AC04-88-DP43495 with EG&G Mound Applied Technologies. Ohio Sales or Use taxes are not to be included in the proposal price. Applicable taxes due or owing to the State of Ohio will be paid by the buyer under Direct Payment Permit No. 98-002230. Refer to Form ML-2487, General Provisions, Article 24, {open_quotes}Federal, State & Local Taxes{close_quotes}. Sellers are advised that purchases of building and construction materials for incorporation into a structure or improvement to a real property which is accepted for ownership by the United States or one of its agencies are exempt from Ohio Sales and Use taxes. Unnecessarily elaborate brochures or other presentations beyond those sufficient to present a complete and effective response to this solicitation are not desired and may be construed as an indication of the seller`s lack of cost consciousness. Elaborate art work, expensive paper and binding, and expensive visual and other presentation aids are neither necessary nor wanted.

  13. Efficacy of pumping manipulation treatment for closed lock of the temporomandibular joint disorder. Correlation between arthrographic findings using limited cone beam X-ray CT for dental use and mouth opening distance in 20 cases

    Energy Technology Data Exchange (ETDEWEB)

    Honda, Kazuya; Uehara, Tamotsu; Arai, Yoshinori; Kashima, Masahiro; Tsukimura, Naoki; Honda, Masahiko; Iwai, Kazuo; Terakado, Masaaki; Shinoda, Koji [Nihon Univ., Tokyo (Japan). School of Dentistry

    2002-01-01

    A study was conducted to evaluate the efficacy of pumping manipulation treatment for closed lock of the temporomandibular joint (TMJ) disorder using limited cone beam X-ray CT for dental use. The subjects were 20 patients with TMJ closed lock. Arthrography and pumping manipulation treatment were performed, and the correlation between maximal mouth opening and arthrographic findings was examined. Arthrography showed 16 cases of anterior disk displacement, and 4 cases of sideways displacement. Disk configuration showed 15 abnormal cases and 3 cases of disk perforation. Before treatment, mouth opening distance was 24.2 mm and 1 week after treatment it was 34.4 mm. After 3 months this had improved significantly to 41.0 mm. Comparison of mouth opening distance with arthrographic findings showed that disk perforation was significantly different after 3 months. These results suggest that pumping manipulation treatment might be useful in patients with TMJ closed lock without internal derangement or disk perforation. (author)

  14. International shipment of light weight radioisotopic heater units (LWRHU) using the USA/9516/B(U)F Mound 1 kW shipping package in support of the {open_quotes}Pluto Express{close_quotes} mission

    Energy Technology Data Exchange (ETDEWEB)

    Barklay, C.D. [EGG Mound Applied Technologies P.O. Box 3000 Miamisburg, Ohio45343-3000 (United States); Merten, C.W. [Mound Engineering and Analysis Group, Inc. 720 Mound Road COS Building 4222 Miamisburg, Ohio45342 (United States)

    1997-01-01

    Radioisotopes have provided heat that has been used to maintain specific operating environments within remote satellites and spacecraft. For the {open_quotes}Pluto Express{close_quotes} mission the {sup 238}PuO{sub 2} fueled light weight radioisotopic heater unit (LWRHU) will be used within the spacecraft. Since the current plan for the {open_quotes}Pluto Express{close_quotes} mission incorporates the use of a Russian launch platform for the spacecraft, the LWRHUs must be transported in an internationally certified shipping container. An internationally certified shipping package that is versatile enough to be reconfigured to transport the LWRHUs that will be required to support the {open_quotes}Pluto Express{close_quotes} mission is the Mound USA/9516/B(U)F. {copyright} {ital 1997 American Institute of Physics.}

  15. Eyes for Learning

    Science.gov (United States)

    Orfield, Antonia

    2008-01-01

    Vision is the dominant sense, and the eyes are connected with almost every other part of the brain. If the vision system is poorly developed, children trying to learn suffer. Without good up close vision, students are handicapped even if no one knows or suspects it--they may not even know it themselves. Students do not know that the way they see…

  16. Short-term effect of latanoprost and timolol eye drops on tear fluid and the ocular surface in patients with primary open-angle glaucoma and ocular hypertension

    DEFF Research Database (Denmark)

    Thygesen, John; Aaen, Kim; Theodorsen, F.;

    2000-01-01

    ophthalmology, open-angle glaucoma, ocular hypertension, glaucoma therapy, latanoprost, timolol, Rose-Bengal test, break-up time, Schirmer-1-test, conjunctival impression cytology......ophthalmology, open-angle glaucoma, ocular hypertension, glaucoma therapy, latanoprost, timolol, Rose-Bengal test, break-up time, Schirmer-1-test, conjunctival impression cytology...

  17. Comparison of Lateral Closing-Wedge Versus Medial Opening-Wedge High Tibial Osteotomy on Knee Joint Alignment and Kinematics in the ACL-Deficient Knee.

    Science.gov (United States)

    Ranawat, Anil S; Nwachukwu, Benedict U; Pearle, Andrew D; Zuiderbaan, Hendrik A; Weeks, Kenneth D; Khamaisy, Saker

    2016-12-01

    Lateral closing-wedge (LCW) and medial opening-wedge (MOW) high tibial osteotomies (HTOs) correct varus knee alignment and stabilize the anterior cruciate ligament (ACL)-deficient knee. Tibiofemoral and patellofemoral alignment and kinematics after HTO are not well quantified. To compare the effect of LCW and MOW HTO on tibiofemoral and patellofemoral alignment in the ACL-deficient knee. Controlled laboratory study. Anterior drawer, Lachman, and pivot-shift tests were performed on cadaveric specimens (N = 16), and anterior tibial translation and tibial rotation were measured for the native and ACL-sectioned knee. The right and left knee of each cadaveric specimen underwent an LCW and MOW HTO, respectively, and stability testing was repeated. All cadavers underwent pre- and postosteotomy computerized tomography with 3-dimensional computer modeling to determine the effect of HTO on posterior tibial slope, as well as tibial and patellofemoral axial plane alignment (tibial axial rotation and patellar axial tilt). Correction to neutral coronal alignment was obtained with both osteotomy techniques; however, larger posterior tibial slope neutralization was achieved with LCW compared with MOW (mean ± SD, 11° ± 3.8° vs 5° ± 5°). LCW demonstrated a greater decrease in anterior tibial translation (P rotation with pivot shift. Relative to MOW, LCW resulted in greater tibial axial rotation and patellar axial tilt (7.7° ± 4° and 5.6° ± 3.9° [LCW], 2.8° ± 2.3° and 2.4° ± 0.9° [MOW], respectively; P rotation and lateral patellar tilt, which may adversely affect the patellofemoral joint. More work is needed to understand the clinical and functional outcome of these biomechanical findings in the ACL-deficient knee. © 2016 The Author(s).

  18. Chasing tics in the human brain: development of open, scheduled and closed loop responsive approaches to deep brain stimulation for tourette syndrome.

    Science.gov (United States)

    Almeida, Leonardo; Martinez-Ramirez, Daniel; Rossi, Peter J; Peng, Zhongxing; Gunduz, Aysegul; Okun, Michael S

    2015-04-01

    Tourette syndrome is a childhood-onset disorder characterized by a combination of motor and vocal tics, often associated with psychiatric comorbidities including attention deficit and hyperactivity disorder and obsessive-compulsive disorder. Despite an onset early in life, half of patients may present symptoms in adulthood, with variable degrees of severity. In select cases, the syndrome may lead to significant physical and social impairment, and a worrisome risk for self injury. Evolving research has provided evidence supporting the idea that the pathophysiology of Tourette syndrome is directly related to a disrupted circuit involving the cortex and subcortical structures, including the basal ganglia, nucleus accumbens, and the amygdala. There has also been a notion that a dysfunctional group of neurons in the putamen contributes to an abnormal facilitation of competing motor responses in basal ganglia structures ultimately underpinning the generation of tics. Surgical therapies for Tourette syndrome have been reserved for a small group of patients not responding to behavioral and pharmacological therapies, and these therapies have been directed at modulating the underlying pathophysiology. Lesion therapy as well as deep brain stimulation has been observed to suppress tics in at least some of these cases. In this article, we will review the clinical aspects of Tourette syndrome, as well as the evolution of surgical approaches and we will discuss the evidence and clinical responses to deep brain stimulation in various brain targets. We will also discuss ongoing research and future directions as well as approaches for open, scheduled and closed loop feedback-driven electrical stimulation for the treatment of Tourette syndrome.

  19. Apraxia of lid opening

    Directory of Open Access Journals (Sweden)

    Jebasingh Y

    2006-01-01

    Full Text Available Apraxia of lid opening is a condition where patients do not have ptosis but have difficulty in overcoming levator palpebrae inhibition. We report a patient who presented with difficulty in opening eyelids with out diurnal variation, ptosis or blepharospasm. The diagnosis of Apraxia of lid opening is confirmed by electro physiology. The possibility of apraxia of lid opening should be considered in patients who present with difficulty in opening eyes. Various causes of Apraxia of lid opening are discussed.

  20. Diabetes eye exams

    Science.gov (United States)

    Diabetic retinopathy - eye exams; Diabetes - eye exams; Glaucoma - diabetic eye exam; Macular edema - diabetic eye exam ... if the doctor who takes care of your diabetes checks your eyes, you need an eye exam ...