A rare disease in an atypical location - Kimura's Disease of the upper extremity

International Nuclear Information System (INIS)

Lam, Alan Cheuk Si; Lau, Vince Wing Hang; Au Yeung, Rex Kwok Him

2015-01-01

Kimura's disease is a rare chronic inflammatory disorder predominantly affecting young Asian male patients, occurring mainly in the head and neck regions. Kimura's disease of the upper extremity is extremely rare, and previous case reports in the literature show similar imaging characteristics with consistent location at the medial epitrochlear region, predominantly with unilateral involvement. We present the first reported case of Kimura's disease affecting the anterolateral aspect of the upper arm, sparing the medial epitrochlear region, illustrating that with typical MR appearance and serology, the involvement of this rare disease in an atypical location still warrants consideration of this diagnosis. There was also bilateral asymmetrical involvement in our patient, suggesting the possibility of a propensity for Kimura's disease affecting the upper extremities to have bilateral involvement, which may necessitate imaging of the clinically asymptomatic contralateral limb in these patients for early lesion identification and treatment. (orig.)

I betraktarens ögon – Betydelsen av kön och ålder för studenters läraromdömen

Directory of Open Access Journals (Sweden)

Martin Karlsson

2011-12-01

Full Text Available Under senare år har studenters läraromdömen allt mer hamnat i fokus inom skola såväl som högre utbildning. Parallellt med dessa utvecklingar har olika typer av internettjänster genom vilka studenter kan betygsätta sina lärare dykt upp i flera länder. I Sverige lanserades 2008 tjänsten ”Studenter tycker till” (STT där studenter kan registrera sig och fylla i bedömningar av lärare enligt kriterierna utlärningsförmåga, kunskap, engagemang och lärandestöd. I denna studie undersöks betydelsen av lärarens kön och ålder för studenters läraromdömen genom en kvantitativ analys av omdömen av 98 högskole- och universitetslärare som givits på hemsidan STT. Syftet är att synliggöra hur sociala markörer, i detta fall om läraren är man eller kvinna, ung eller gammal, spelar en stor roll för hur en lärare utvärderas. Resultaten visar att kvinnor och unga lärare systematiskt ges lägre betyg av studenter, än män och äldre lärare. Studenter är således inte könsblinda eller oberoende av föreställningar om förhållandet mellan ålder och kompetens i sina bedömningar. Studien aktualiserar betydelsen av sociala markörer så som kön och ålder måste synliggöras och tas i beaktning när studenters utvärderingar av lärare och kurser behandlas inom högre utbildning.

Explosion i rötkammare med biogas

DEFF Research Database (Denmark)

Hedlund, Frank Huess

2017-01-01

En biogasreaktor exploderade 1990 på Vejle Centrala reningsverk. Nu, 24 år senare, när biogas är populärare än någonsin, har händelsen helt försvunnit från tillgängliga, öppna källor......En biogasreaktor exploderade 1990 på Vejle Centrala reningsverk. Nu, 24 år senare, när biogas är populärare än någonsin, har händelsen helt försvunnit från tillgängliga, öppna källor...

Samstämmighet i lärares bedömning av nationella prov i läsförståelse

Directory of Open Access Journals (Sweden)

Michael Tengberg

2016-04-01

Full Text Available Tillförlitlighet i bedömning är en avgörande komponent i varje testprogram där testtagares resultat bygger på bedömares tolkningar utifrån en bedömningsskala eller en bedömningsguide. Utförliga svar på öppna uppgifter bedöms exempelvis sällan som antingen ”rätt” eller ”fel”. Istället tillämpas skalan eller bedömningsguiden för att fastställa i vilken utsträckning svaret uppvisar den efterfrågade kompetensen. I den här artikeln redovisas resultat från en studie av bedömarreliabilitet på öppna uppgifter i det nationella provets svenska läsförståelsedel i årskurs nio.För att undersöka i vilken mån provsystemet skapar förutsättningar för god bedömarreliabilitet har sex lärare fått bedöma tre elevers lösningar av 14 öppna uppgifter, totalt 252 bedömningar. Analyserna innefattar konsensusestimat (procentuell samstämmighet och Cohens kappa och konsistensestimat (ICC. Dessutom har kvalitativa analyser genomförts på uppgiftsnivå för att visa på aspekter i uppgiftskonstruktionen som kan ligga till grund för låg bedömarreliabilitet.Resultaten från studien visar på moderata nivåer av bedömarreliabilitet, både ifråga om kappavärden (.73 och ICC (.82, vilket motsvarar en variation mellan bedömningarna som får stora konsekvenser för elevernas slutgiltiga provresultat. I artikeln diskuterar vi resultatens implikationer för rättvis bedömning av elevers läsförmåga i Sverige. Vi för också ett resonemang om olika sätt att stärka bedömarreliabiliteten det nationella provet i läsförståelse.

Bristande samsyn i lärares definition av hot och våld : En kvalitativ studie om förekomst av hot och våld mot lärare på högstadieskolor.

OpenAIRE

Eklund, Anton; Johansson, Tommy

2017-01-01

Denna kvalitativa studie syftar till att studera förekomsten av hot och våld mot lärare på högstadieskolor, hur man på de undersökta skolorna arbetar med att minimera förekomsten av hot och våld samt hur lärare definierar sin syn på vad som kan vara hot och våld från föräldrar och elever. Studien är baserad på ett riktat bekvämlighetsurval där skyddsombud på högstadieskolor i den undersökta kommunen valdes ut. I samband med analysen av studiens resultat har Lintons rollteori använts för att s...

<i>PALB2i>, <i>CHEK2i> and <i>ATM i>rare variants and cancer risk

DEFF Research Database (Denmark)

Southey, Melissa C; Goldgar, David E; Winqvist, Robert

2016-01-01

2 mutations. We aimed to estimate the relative risks associated with specific rare variants in PALB2, CHEK2 and ATM via a multicentre case-control study. METHODS: We genotyped 10 rare mutations using the custom iCOGS array: PALB2 c.1592delT, c.2816T>G and c.3113G>A, CHEK2 c.349A>G, c.538C>T, c.715G...

Anomalous magnetoresistance in antiferromagnetic polycrystalline materials R2Ni3Si5 (R=rare earth)

International Nuclear Information System (INIS)

Mazumdar, C.; Nigam, A.K.; Nagarajan, R.; Gupta, L.C.; Chandra, G.; Padalia, B.D.; Godart, C.; Vijayaraghaven, R.

1997-01-01

Magnetoresistance (MR) studies on polycrystalline R 2 Ni 3 Si 5 , (R=Y, rare earth) which order antiferromagnetically at low temperatures, are reported here. MR of the Nd, Sm, and Tb members of the series exhibit positive giant magnetoresistance, largest among polycrystalline materials (85%, 75%, and 58% for Tb 2 Ni 3 Si 5 , Sm 2 Ni 3 Si 5 , and Nd 2 Ni 3 Si 5 , respectively, at 4.4 K in a field of 45 kG). These materials have, to the best of our knowledge, the largest positive GMR reported ever for any bulk polycrystalline compounds. The magnitude of MR does not correlate with the rare earth magnetic moments. We believe that the structure of these materials, which can be considered as a naturally occurring multilayer of wavy planes of rare earth atoms separated by Ni endash Si network, plays a role. The isothermal MR of other members of this series (R=Pr,Dy,Ho) exhibits a maximum and a minimum, below their respective T N close-quote s. We interpret these in terms of a metamagnetic transition and short-range ferromagnetic correlations. The short-range ferromagnetic correlations seem to be dominant in the temperature region just above T N . copyright 1997 American Institute of Physics

Simulation of the 23 July 2012 Extreme Space Weather Event: What if This Extremely Rare CME Was Earth Directed?

Science.gov (United States)

Ngwira, Chigomezyo M.; Pulkkinen, Antti; Mays, M. Leila; Kuznetsova, Maria M.; Galvin, A. B.; Simunac, Kristin; Baker, Daniel N.; Li, Xinlin; Zheng, Yihua; Glocer, Alex

2013-01-01

Extreme space weather events are known to cause adverse impacts on critical modern day technological infrastructure such as high-voltage electric power transmission grids. On 23 July 2012, NASA's Solar Terrestrial Relations Observatory-Ahead (STEREO-A) spacecraft observed in situ an extremely fast coronal mass ejection (CME) that traveled 0.96 astronomical units (approx. 1 AU) in about 19 h. Here we use the SpaceWeather Modeling Framework (SWMF) to perform a simulation of this rare CME.We consider STEREO-A in situ observations to represent the upstream L1 solar wind boundary conditions. The goal of this study is to examine what would have happened if this Rare-type CME was Earth-bound. Global SWMF-generated ground geomagnetic field perturbations are used to compute the simulated induced geoelectric field at specific ground-based active INTERMAGNET magnetometer sites. Simulation results show that while modeled global SYM-H index, a high-resolution equivalent of the Dst index, was comparable to previously observed severe geomagnetic storms such as the Halloween 2003 storm, the 23 July CME would have produced some of the largest geomagnetically induced electric fields, making it very geoeffective. These results have important practical applications for risk management of electrical power grids.

An extremely rare neoplasm, histiocytic sarcoma: A report of two cases with an aggressive clinical course

Directory of Open Access Journals (Sweden)

Erkan Kayikcioglu

2017-07-01

Conclusions: HS is an extremely rare malignant neoplasm of the monocytic/macrophage lineage, with no standardized chemotherapy regimen for multisystemic disease. Metastatic patients have a more aggressive clinical course than those with unifocal disease.

Extreme project. Progress report 2006; Projet EXTREME. Rapport d'avancement 2006

Energy Technology Data Exchange (ETDEWEB)

Eyrolle, F.; Masson, O.; Charmasson, S

2007-07-01

The E.X.T.R.E.M.E. project introduced in 2005 to the S.E.S.U.R.E. / L.E.R.C.M. has for objectives to acquire data on the consequences of the extreme climatic meteorological episodes on the distribution of the artificial radioisotopes within the various compartments of the geosphere. This report presents the synthesis of the actions developed in 2006 in positioning and in co financing of the project by means of regional or national research programs (C.A.R.M.A., E.X.T.R.E.M.A., E.C.C.O.R.E.V.I.), of data acquisition, valuation and scientific collaboration. (N.C.)

Using Extreme Phenotype Sampling to Identify the Rare Causal Variants of Quantitative Traits in Association Studies

OpenAIRE

Li, Dalin; Lewinger, Juan Pablo; Gauderman, William J.; Murcray, Cassandra Elizabeth; Conti, David

2011-01-01

Variants identified in recent genome-wide association studies based on the common-disease common-variant hypothesis are far from fully explaining the hereditability of complex traits. Rare variants may, in part, explain some of the missing hereditability. Here, we explored the advantage of the extreme phenotype sampling in rare-variant analysis and refined this design framework for future large-scale association studies on quantitative traits. We first proposed a power calculation approach fo...

An Extremely Rare Case of Advanced Metastatic Small Cell Neuroendocrine Carcinoma of Sinonasal Tract

Directory of Open Access Journals (Sweden)

Yu Yu Thar

2016-01-01

Full Text Available Small cell neuroendocrine carcinoma (SNEC is a rare form of malignancy. It mainly presents as bronchogenic neoplasm, and the extrapulmonary form accounts for only 0.1% to 0.4% of all cancers. These extrapulmonary tumors have been described most frequently in the urinary bladder, prostate, esophagus, stomach, colon and rectum, gall bladder, head and neck, cervix, and skin. Primary SNEC of the sinonasal tract is extremely rare with only less than 100 cases reported in the literature. Because of extreme rarity and aggressiveness of the tumor, the management for this entity varies considerably mandating multimodality approach. In this paper, we report a patient presented with left-sided facial swelling, and the histopathologic examination confirmed primary SNEC of left sinonasal tract. The tumor involved multiple paranasal sinuses with invasion into the left orbit and left infratemporal fossa and metastasized to cervical lymph nodes and bone. The patient encountered devastating outcome in spite of optimal medical management and treatment with palliative chemotherapy highlighting the necessity for further research of primary SNEC of head and neck.

Understanding r-process nucleosynthesis with dwarf galaxies

Science.gov (United States)

Ji, Alexander P.

2018-06-01

The Milky Way's faintest dwarf galaxy satellites each sample short, independent bursts of star formation from the first 1-2 Gyr of the universe. Their simple formation history makes them ideal systems to understand how rare events like neutron star mergers contribute to early enrichment of r-process elements. I will focus on the ultra-faint galaxy Reticulum II, which experienced a single prolific r-process event that left ~80% of its stars extremely enriched in r-process elements. I will present abundances of ~40 elements derived from the highest signal-to-noise high-resolution spectrum ever taken for an ultra-faint dwarf galaxy star. Precise measurements of elements from all three r-process peaks reaffirm the universal nature of the r-process abundance pattern from Ba to Ir. The first r-process peak is significantly lower than solar but matches other r-process enhanced stars. This constrains the neutron-richness of r-process ejecta in neutron star mergers. The radioactive element thorium is detected with a somewhat low abundance. Naive application of currently predicted initial production ratios could imply an age >20 Gyr, but more likely indicates that the initial production ratios require revision. The abundance of lighter elements up to Zn are consistent with extremely metal-poor Milky Way halo stars. These elements may eventually provide a way to test for other hypothesized r-process sites, but only after a more detailed understanding of the chemical evolution in this galaxy. Reticulum II provides a clean view of early r-process enrichment that can be used to understand the increasing number of r-process measurements in other dwarf galaxies.

THE LINK BETWEEN RARE-EARTH PEAK FORMATION AND THE ASTROPHYSICAL SITE OF THE R PROCESS

Energy Technology Data Exchange (ETDEWEB)

Mumpower, Matthew R. [Theory Division, Los Alamos National Laboratory, Los Alamos, NM 87544 (United States); McLaughlin, Gail C. [Department of Physics, North Carolina State University, Raleigh, NC 27695 (United States); Surman, Rebecca [Department of Physics, University of Notre Dame, Notre Dame, IN 46556 (United States); Steiner, Andrew W., E-mail: matthew@mumpower.net [Department of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996 (United States)

2016-12-20

The primary astrophysical source of the rare-earth elements is the rapid neutron capture process ( r process). The rare-earth peak that is seen in the solar r -process residuals has been proposed to originate as a pile-up of nuclei during the end of the r process. We introduce a new method utilizing Monte Carlo studies of nuclear masses in the rare-earth region, that includes self-consistently adjusting β -decay rates and neutron capture rates, to find the mass surfaces necessary for the formation of the rare-earth peak. We demonstrate our method with two types of astrophysical scenario, one corresponding to conditions typical of hot winds from core-collapse supernovae and stellar-mass accretion disks, and one corresponding to conditions typical of the ejection of the material from the tidal tails of neutron star mergers. In each type of astrophysical condition, this method successfully locates a region of enhanced stability in the mass surface that is responsible for the rare-earth peak. For each scenario, we find that the change in the mass surface has qualitatively different features, thus future measurements can shed light on the type of environment in which the r process occurred.

THE LINK BETWEEN RARE-EARTH PEAK FORMATION AND THE ASTROPHYSICAL SITE OF THE R PROCESS

International Nuclear Information System (INIS)

Mumpower, Matthew R.; McLaughlin, Gail C.; Surman, Rebecca; Steiner, Andrew W.

2016-01-01

The primary astrophysical source of the rare-earth elements is the rapid neutron capture process ( r process). The rare-earth peak that is seen in the solar r -process residuals has been proposed to originate as a pile-up of nuclei during the end of the r process. We introduce a new method utilizing Monte Carlo studies of nuclear masses in the rare-earth region, that includes self-consistently adjusting β -decay rates and neutron capture rates, to find the mass surfaces necessary for the formation of the rare-earth peak. We demonstrate our method with two types of astrophysical scenario, one corresponding to conditions typical of hot winds from core-collapse supernovae and stellar-mass accretion disks, and one corresponding to conditions typical of the ejection of the material from the tidal tails of neutron star mergers. In each type of astrophysical condition, this method successfully locates a region of enhanced stability in the mass surface that is responsible for the rare-earth peak. For each scenario, we find that the change in the mass surface has qualitatively different features, thus future measurements can shed light on the type of environment in which the r process occurred.

AUTOMATISATION ET CONTROLE A DISTANCE DE L'INSTRUMENTATION DU LASER R.I.L.I.S. A ISOLDE

CERN Document Server

Chevallay, E

2003-01-01

A Isolde, les physiciens utilisent pour leurs expériences des isotopes rares produits par l'interaction d'un faisceau de protons provenant du synchrotron Booster et d'une cible métallique. Derrière cette cible, les isotopes qui sont produits et accélérés ne sont pas tous du même type et de la même masse. Des aimants de spectromètres (GPS ou HRS) sélectionnent les isotopes requis en fonction du rapport masse/charge. De plus, l'utilisation d'un laser de puissance pour ioniser les isotopes, le laser R.I.L.I.S. (Résonance Ionization Laser Ion Source), permet une bien meilleure sélectivité. Le système de lasers RILIS a été construit par la collaboration Isolde [1] en 1990. Son implication dans le programme de physique d'Isolde représente 50 % des expériences approuvées. Etant l'un des éléments clefs de la production d'isotopes rares à Isolde, il a bien entendu été intégré dans le programme de consolidation lancé en 2000 [2]. La consolidation du laser lui-même n'entre pas dans le cadre d...

Extreme project. Progress report 2006

International Nuclear Information System (INIS)

Eyrolle, F.; Masson, O.; Charmasson, S.

2007-01-01

The E.X.T.R.E.M.E. project introduced in 2005 to the S.E.S.U.R.E. / L.E.R.C.M. has for objectives to acquire data on the consequences of the extreme climatic meteorological episodes on the distribution of the artificial radioisotopes within the various compartments of the geosphere. This report presents the synthesis of the actions developed in 2006 in positioning and in co financing of the project by means of regional or national research programs (C.A.R.M.A., E.X.T.R.E.M.A., E.C.C.O.R.E.V.I.), of data acquisition, valuation and scientific collaboration. (N.C.)

Teorin i praktiken - praktiken i teorin

DEFF Research Database (Denmark)

Lund, Birthe; Lindhart, Lars

2006-01-01

Vad ligger bakom våra föreställningar om "teori" och "praktik"? Är de varandras motsatser och oförenliga? Eller är de aspekter både i lärande och yrkesutövande? I boken talas om den "praktikchock" som ofta möter blivande lärare när de är ute i skolornas "verklighet" för första gången. Denna antol...... antologi med alla sina lärda, inspirerande och insiktsfulla bidrag vänder sig till verksamma lärare och lärarstuderande som närmar sig slutet av sin utbildning och alla andra som arbetar med mötet mellan teori och praktik....

A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.

Science.gov (United States)

Rovelet-Lecrux, Anne; Legallic, Solenn; Wallon, David; Flaman, Jean-Michel; Martinaud, Olivier; Bombois, Stéphanie; Rollin-Sillaire, Adeline; Michon, Agnès; Le Ber, Isabelle; Pariente, Jérémie; Puel, Michèle; Paquet, Claire; Croisile, Bernard; Thomas-Antérion, Catherine; Vercelletto, Martine; Lévy, Richard; Frébourg, Thierry; Hannequin, Didier; Campion, Dominique

2012-06-01

Studying rare extreme forms of Alzheimer disease (AD) may prove to be a useful strategy in identifying new genes involved in monogenic determinism of AD. Amyloid precursor protein (APP), PSEN1, and PSEN2 mutations account for only 85% of autosomal dominant early-onset AD (ADEOAD) families. We hypothesised that rare copy number variants (CNVs) could be involved in ADEOAD families without mutations in known genes, as well as in rare sporadic young-onset AD cases. Using high-resolution array comparative genomic hybridisation, we assessed the presence of rare CNVs in 21 unrelated ADEOAD cases, having no alteration on known genes, and 12 sporadic AD cases, with an age of onset younger than 55 years. The analysis revealed the presence of 7 singleton CNVs (4 in ADEOAD and 3 in sporadic cases) absent in 1078 controls and 912 late-onset AD cases. Strikingly, 4 out of 7 rearrangements target genes (KLK6, SLC30A3, MEOX2, and FPR2) encoding proteins that are tightly related to amyloid-β peptide metabolism or signalling. Although these variants are individually rare and restricted to particular subgroups of patients, these findings support the causal role, in human pathology, of a set of genes coding for molecules suspected for a long time to modify Aβ metabolism or signalling, and for which animal or cellular models have already been developed.

I-Love-Q to the extreme

Science.gov (United States)

Silva, Hector O.; Yunes, Nicolás

2018-01-01

Certain bulk properties of neutron stars, in particular their moment of inertia, rotational quadrupole moment and tidal Love number, when properly normalized, are related to one another in a nearly equation of state independent way. The goal of this paper is to test these relations with extreme equations of state at supranuclear densities constrained to satisfy only a handful of generic, physically sensible conditions. By requiring that the equation of state be (i) barotropic and (ii) its associated speed of sound be real, we construct a piecewise function that matches a tabulated equation of state at low densities, while matching a stiff equation of state parametrized by its sound speed in the high-density region. We show that the I-Love-Q relations hold to 1 percent with this class of equations of state, even in the extreme case where the speed of sound becomes superluminal and independently of the transition density. We also find further support for the interpretation of the I-Love-Q relations as an emergent symmetry due to the nearly constant eccentricity of isodensity contours inside the star. These results reinforce the robustness of the I-Love-Q relations against our current incomplete picture of physics at supranuclear densities, while strengthening our confidence in the applicability of these relations in neutron star astrophysics.

Malignant Hidradenocarcinoma in the Lower Extremity: A Case Report of a Rare Tumor.

Science.gov (United States)

Kane, Brendan; Adler, Evan; Bhandari, Tarun; Rose, Michael; DiGuglielmo, Nicola; Sun, Xiu

Malignant hidradenocarcinomas are rare soft tissue tumors of sweat gland origin. We present the case of a soft tissue, fungating tumor of 15 years' duration of the medial ankle in an 85-year-old male that exhibited malignant features clinically and radiographically. Subsequent punch biopsy revealed a diagnosis of malignant hidradenocarcinoma. Given the risk of recurrence and the poor radiation and chemotherapy options, the patient initially decided to leave the lesion untreated. However, he soon developed lower extremity cellulitis from the exposed lesion and decided to have the tumor excised, eliminating the source of the infection. In the present case study, we discuss the etiology, clinical and radiographic characteristics, and treatment options for this rare lesion. At the 18-month follow-up visit, he had had no recurrence of the lesion. Copyright © 2017 The American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

Usher syndrome Type I in an adult Nepalese male: a rare case report.

Science.gov (United States)

Sahu, Sabin; Singh, Sanjay Kumar

2017-07-01

Usher syndrome, also known as retinitis pigmentosa-dysacusis syndrome, is an extremely rare genetic disorder, characterized by retinitis pigmentosa (RP) and congenital sensorineural hearing loss. It has been estimated to account for 3-6% of the congenitally deaf population, upto 8-33% of individuals with RP and half of all cases with combined deafness and blindness (Vernon M,1969; Boughman JA et al,1983). The prevalence of Usher syndrome have been reported to range from 3.5 to 6.2 per 100,000 in different populations (Vernon M,1969; Boughman JA et al,1983; Yan D et al, 2010). We report a case of Usher syndrome type I in an adult Nepalese male with typical congenital profound hearing loss, and night blindness secondary to retinitis pigmentosa. © NEPjOPH.

Musikbranschen i förändring : Artistens möjligheter med och utan skivbolag

OpenAIRE

Järnström, Sofia Maria

2011-01-01

Syftet med mitt examensarbete är att undersöka i vilken utsträckning artister kan nå en publik utan att ingå ett skivkontrakt och att klargöra för vilka kanaler som finns tillgäng-liga för självständig marknadsföring. Undersökningen är kvalitativ och jag kommer att fokusera på fyra intervjuer med personer inom branschen. Jag fokuserar på dessa frågor: 1) Hur kan en artist nå ut med sin musik, utan att ha ett skivbolag bakom sig som marknadsförare och distributör? 2) Vilka nya...

Calculations of the magnetic properties of R2M14B intermetallic compounds (R=rare earth, M=Fe, Co)

International Nuclear Information System (INIS)

Ito, Masaaki; Yano, Masao; Dempsey, Nora M.; Givord, Dominique

2016-01-01

The hard magnetic properties of “R–M–B” (R=rare earth, M=mainly Fe) magnets derive from the specific intrinsic magnetic properties encountered in Fe-rich R 2 M 14 B compounds. Exchange interactions are dominated by the 3d elements, Fe and Co, and may be modeled at the macroscopic scale with good accuracy. Based on classical formulae that relate the anisotropy coefficients to the crystalline electric field parameters and exchange interactions, a simple numerical approach is used to derive the temperature dependence of anisotropy in various R 2 Fe 14 B compounds (R=Pr, Nd, Dy). Remarkably, a unique set of crystal field parameters give fair agreement with the experimentally measured properties of all compounds. This implies reciprocally that the properties of compounds that incorporate a mixture of different rare-earth elements may be predicted accurately. This is of special interest for material optimization that often involves the partial replacement of Nd with another R element and also the substitution of Co for Fe. - Highlights: • Anisotropy constants derived from CEF parameters of R 2 M 14 B compounds (M=Fe, Co). • Anisotropy constants of all R 2 Fe 14 B compounds using unique set of CEF parameters. • Moment non-collinearity in magnetization processes under B app along hard axis.

Rare (Earth Elements [score

Directory of Open Access Journals (Sweden)

Camilo Méndez

2014-12-01

Full Text Available Rare (Earth Elements is a cycle of works for solo piano. The cycle was inspired by James Dillon’s Book of Elements (Vol. I-V. The complete cycle will consist of 14 pieces; one for each selected rare (earth element. The chosen elements are Neodymium, Erbium, Tellurium, Hafnium, Tantalum, Technetium, Indium, Dysprosium, Lanthanium, Cerium, Europium, Terbium, Yttrium and Darmstadtium. These elements were selected due to their special atomic properties that in many cases make them extremely valuable for the development of new technologies, and also because of their scarcity. To date, only 4 works have been completed Yttrium, Technetium, Indium and Tellurium.

Cryptococcoma mimicking a brain tumor in an immunocompetent patient: case report of an extremely rare presentation.

Science.gov (United States)

Paiva, Aline Lariessy Campos; Aguiar, Guilherme Brasileiro de; Lovato, Renan Maximilian; Zanetti, Arthus Vilar Deolindo; Panagopoulos, Alexandros Theodoros; Veiga, José Carlos Esteves

2017-11-06

Central nervous system (CNS) infectious diseases have high prevalence in developing countries and their proper diagnosis and treatment are very important for public health planning. Cryptococcus neoformans is a fungus that may cause several CNS manifestations, especially in immunocompromised patients. Cryptococcal meningitis is the most common type of involvement. Mass-effect lesions are uncommon: they are described as cryptococcomas and their prevalence is even lower among immunocompetent patients. The aim here was to report an extremely rare case of cryptococcoma causing a mass effect and mimicking a brain tumor in an immunocompetent patient. The literature on CNS cryptococcal infections was reviewed with emphasis on cryptococcomas. Clinical, surgical and radiological data on a female patient with this rare presentation of cryptococcoma mimicking a brain tumor are described. A 54-year-old female patient presented to the emergency department with a rapid-onset progressive history of confusion and completely dependency for basic activities. Neuroimaging showed a left occipital lesion and neurosurgical treatment was proposed. From histopathological evaluation, a diagnosis of cryptococcoma was established. She received clinical support with antifungals, but despite optimal clinical treatment, her condition evolved to death. Cryptococcal infections have several forms of presentation and, in immunocompetent patients, their manifestation may be even more different. Cryptococcoma is an extremely rare presentation in which proper surgical and clinical treatment should be instituted as quickly as possible, but even so, there is a high mortality rate.

Tumor therapy with 125I-octreotide and 125I-UdR

International Nuclear Information System (INIS)

Fan, W.; Zhu, R.; Yang, C.; Sun, J.J.; Xu, Y.J.; Zhang, Y.J.; Wu, M.J.; Wang, D.J.

2005-01-01

Purpose: To determine the tumor cell damage effect with Auger-electron emitter 125 I in different chemical states. Methods: (1) [Tyr 3 ] octreotide (TOC) and UdR are labeled with 125 I,respectively. (2) Receptor analysis of 125 I-TOC on small cell lung cancer (SCLC) NCI-H446 cell lines is performed comparing with normal lymph cells. NCI-H446 cells added various dose of 125 I-TOC are incubated for different time with 125 I-Nal and non-labeled TOC as control. The capacity of NCI-H446 cell lines bound and internalization of 125 I TOC are determined. The radiation damage of tumor cells is measured by MTF methods. (3) The killing effects of 125 I-UdR in human pancreatic cancer cell line Bax-Pc and Sca-BER bladder carcinoma cells are evaluated with the similar methods. I-UdR penetrating into the Sca-BER cell nucleus is observed with confocal microscope. The grow suppression and clonogenic formation of Sca-BER cells after incubation with 125 I-UdR are analyzed. Proliferation fraction and S phase cell fraction of Sca-BER cell added 125 I-UdR is measured with flow cytometric analysis. Results: (1) Kd=(0.56∼2.0) x 10 -11 mol/L and B max =(1.17∼2.0) x 10 5 cell site are obtained by receptor analysis of 125 I-TOC on NCI-H446 cells. Comparatively, the difference between total binding and non-specific binding is low and there is no saturation of specific binding for normal lymphocyte. About 50% of 125 I-TOC is internalized into the NCI-H446 cell nucleus at 24h after incubation. The damige of NCI-H446 cells by 125 I-TOC is clearly observed. (2) The penetration amount of 125 I-UdR into cell nucleus increases with the incubate time when the concentration of 125 I-UdR is in the range of 10∼500 kBq/mL and reaches the peak fraction of 94% at 36 h after incubation. The radioactivity of 125 I-UdR is then achieved equelibration and no more increased with time. The linear correlation with γ=0.867∼0.978 between the concentration of 125 I-UdR in cell nucleus and the incubation time

Extremely rare collapse and build-up of turbulence in stochastic models of transitional wall flows.

Science.gov (United States)

Rolland, Joran

2018-02-01

This paper presents a numerical and theoretical study of multistability in two stochastic models of transitional wall flows. An algorithm dedicated to the computation of rare events is adapted on these two stochastic models. The main focus is placed on a stochastic partial differential equation model proposed by Barkley. Three types of events are computed in a systematic and reproducible manner: (i) the collapse of isolated puffs and domains initially containing their steady turbulent fraction; (ii) the puff splitting; (iii) the build-up of turbulence from the laminar base flow under a noise perturbation of vanishing variance. For build-up events, an extreme realization of the vanishing variance noise pushes the state from the laminar base flow to the most probable germ of turbulence which in turn develops into a full blown puff. For collapse events, the Reynolds number and length ranges of the two regimes of collapse of laminar-turbulent pipes, independent collapse or global collapse of puffs, is determined. The mean first passage time before each event is then systematically computed as a function of the Reynolds number r and pipe length L in the laminar-turbulent coexistence range of Reynolds number. In the case of isolated puffs, the faster-than-linear growth with Reynolds number of the logarithm of mean first passage time T before collapse is separated in two. One finds that ln(T)=A_{p}r-B_{p}, with A_{p} and B_{p} positive. Moreover, A_{p} and B_{p} are affine in the spatial integral of turbulence intensity of the puff, with the same slope. In the case of pipes initially containing the steady turbulent fraction, the length L and Reynolds number r dependence of the mean first passage time T before collapse is also separated. The author finds that T≍exp[L(Ar-B)] with A and B positive. The length and Reynolds number dependence of T are then discussed in view of the large deviations theoretical approaches of the study of mean first passage times and

Extremely rare collapse and build-up of turbulence in stochastic models of transitional wall flows

Science.gov (United States)

Rolland, Joran

2018-02-01

This paper presents a numerical and theoretical study of multistability in two stochastic models of transitional wall flows. An algorithm dedicated to the computation of rare events is adapted on these two stochastic models. The main focus is placed on a stochastic partial differential equation model proposed by Barkley. Three types of events are computed in a systematic and reproducible manner: (i) the collapse of isolated puffs and domains initially containing their steady turbulent fraction; (ii) the puff splitting; (iii) the build-up of turbulence from the laminar base flow under a noise perturbation of vanishing variance. For build-up events, an extreme realization of the vanishing variance noise pushes the state from the laminar base flow to the most probable germ of turbulence which in turn develops into a full blown puff. For collapse events, the Reynolds number and length ranges of the two regimes of collapse of laminar-turbulent pipes, independent collapse or global collapse of puffs, is determined. The mean first passage time before each event is then systematically computed as a function of the Reynolds number r and pipe length L in the laminar-turbulent coexistence range of Reynolds number. In the case of isolated puffs, the faster-than-linear growth with Reynolds number of the logarithm of mean first passage time T before collapse is separated in two. One finds that ln(T ) =Apr -Bp , with Ap and Bp positive. Moreover, Ap and Bp are affine in the spatial integral of turbulence intensity of the puff, with the same slope. In the case of pipes initially containing the steady turbulent fraction, the length L and Reynolds number r dependence of the mean first passage time T before collapse is also separated. The author finds that T ≍exp[L (A r -B )] with A and B positive. The length and Reynolds number dependence of T are then discussed in view of the large deviations theoretical approaches of the study of mean first passage times and multistability

Pårørende i psykiatrien

DEFF Research Database (Denmark)

Thomassen, Preben

Pårørende i psykiatrien: Formulerede visioner og pårørendeorganisationers ønsker og oplevelser i forhold til Regionernes politiske visioner med fokus på Region Midtjylland. Afrapportering fra projekt udført i VIAUC´s regi i Videncenter for Sundhedsfremme, Sundhedsteknologi og Rehabilitering under...

Mandelbrot's Extremism

NARCIS (Netherlands)

Beirlant, J.; Schoutens, W.; Segers, J.J.J.

2004-01-01

In the sixties Mandelbrot already showed that extreme price swings are more likely than some of us think or incorporate in our models.A modern toolbox for analyzing such rare events can be found in the field of extreme value theory.At the core of extreme value theory lies the modelling of maxima

Carcinoma ex basal cell adenoma of the parotid gland: A report of an extremely rare case.

Science.gov (United States)

Kusafuka, Kimihide; Kawasaki, Takuya; Nakajima, Takashi; Sugino, Takashi

2017-07-01

Malignant non-basaloid tumors that arise from basal cell adenoma (BCA) are extremely rare. The patient was a 72-year-old Japanese male, who had noticed swelling of the left parotid region 21 years ago. A superficial lobectomy was performed. About 60% of the tumor was made up of cribriform and trabecular tissue composed of basaloid cells, which exhibited mild atypia and nuclear expression of β-catenin. This portion of the tumor was considered to be a BCA. In the other part of the tumor, the proliferation of large eosinophilic atypical cells, most of which formed intraductal structures, was observed. These tumor cells displayed cellular atypia, and some of them formed Roman bridge structures or contributed to intracapsular invasion. Immunohistochemically, these cells were positive for cytokeratin 7, gross cystic disease fluid proten-15 (GCDFP-15), androgen receptor (AR), and mammaglobin (MMG) and exhibited a high Ki-67 labeling index. So, this portion of the tumor was considered to be a salivary duct carcinoma (SDC). The tumor's final diagnosis was SDC ex BCA (intracapsular type), which is extremely rare. GCDFP-15, AR, MMG, and Ki-67 are useful immunohistochemical markers for diagnosing SDC ex BCA. © 2017 The Authors. Pathology International Published by Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.

Electronic, elastic and optical properties of divalent (R+2X) and trivalent (R+3X) rare earth monochalcogenides

Science.gov (United States)

Kumar, V.; Chandra, S.; Singh, J. K.

2017-08-01

Based on plasma oscillations theory of solids, simple relations have been proposed for the calculation of bond length, specific gravity, homopolar energy gap, heteropolar energy gap, average energy gap, crystal ionicity, bulk modulus, electronic polarizability and dielectric constant of rare earth divalent R+2X and trivalent R+3X monochalcogenides. The specific gravity of nine R+2X, twenty R+3X, and bulk modulus of twenty R+3X monochalcogenides have been calculated for the first time. The calculated values of all parameters are compared with the available experimental and the reported values. A fairly good agreement has been obtained between them. The average percentage deviation of two parameters: bulk modulus and electronic polarizability for which experimental data are known, have also been calculated and found to be better than the earlier correlations.

An Extremely Rare and Unusual Case of Retroperitoneal and Pelvic Metastasis from Squamous Cell Carcinoma of Vallecula

Directory of Open Access Journals (Sweden)

Abhishek Purkayastha

2016-06-01

Full Text Available We report an extremely rare and unusual case of retroperitoneal and pelvic metastasis from primary squamous cell carcinoma of vallecula. Generally carcinoma oropharynx metastasizes to lungs, liver and bone while retroperitoneal and pelvic metastasis is rarely heard of. To the best of our knowledge this case is one of the scantly reported cases ever of this kind in the world.  A 60-year-old male presented with dysphagia and hoarseness of voice of four month duration.  Computed tomography (CT scan face and neck showed growth right vallecula. Biopsy of lesion showed squamous cell carcinoma. Metastatic work up was negative. He received definitive chemo-radiation. Patient during follow up presented with dyspepsia, abdominal discomfort and weight loss. Whole body positron emission tomography (WB PET scan revealed retroperitoneal and pelvic lymph node deposits which were confirmed as metastasis of squamous cell carcinoma by CT guided fine needle aspiration cytology (FNAC. Patient was exhibited palliative chemotherapy but his general condition deteriorated and he finally succumbed to his metastatic illness. This case is being reported to highlight its extreme rarity, the diagnostic and therapeutic challenges it presented and its overall dismal prognosis.

Rent vand i 150 år

DEFF Research Database (Denmark)

Arvin, Erik

2003-01-01

Vandforsyningen i Odense har været en succes siden begyndelsen i 1853. Ny gælder det om at fastholde landvindingerne, og det bør bl.a. ske ved at bevare det fynske selveje i stedet for at kaste sig i armene på en storkoncern.......Vandforsyningen i Odense har været en succes siden begyndelsen i 1853. Ny gælder det om at fastholde landvindingerne, og det bør bl.a. ske ved at bevare det fynske selveje i stedet for at kaste sig i armene på en storkoncern....

Lärplatta som verktyg för elever i behov av särskilt stöd! : En specialpedagogisk studie om hur elever i åk 4-7 använder lärplatta i klassrummet och hur uppföljning av användningen sker

OpenAIRE

Lindgren, Ditte; Nordström, Ulrika

2017-01-01

Studiens syfte var att få kunskap om hur lärplatta används som verktyg för elever i behov av särskilt stöd i åk 4-7, samt om lärplattan används utifrån specialpedagogens syfte för den enskilda eleven med den. Använda datainsamlingsmetoder är kvalitativa intervjuer med specialpedagoger, lärare och elever, samt elevobservationer. De frågeställningar som studien sökt svar på är: i vilket syfte valdes lärplatta som verktyg av specialpedagog för elever i behov av särskilt stöd, hur använder elever...

Properties of Extreme Precipitation and Their Uncertainties in 3-year GPM Precipitation Radar Data

Science.gov (United States)

Liu, N.; Liu, C.

2017-12-01

Extreme high precipitation rates are often related to flash floods and have devastating impacts on human society and the environments. To better understand these rare events, 3-year Precipitation Features (PFs) are defined by grouping the contiguous areas with nonzero near-surface precipitation derived using Global Precipitation Measurement (GPM) Ku band Precipitation Radar (KuPR). The properties of PFs with extreme precipitation rates greater than 20, 50, 100 mm/hr, such as the geographical distribution, volumetric precipitation contribution, seasonal and diurnal variations, are examined. In addition to the large seasonal and regional variations, the rare extreme precipitation rates often have a larger contribution to the local total precipitation. Extreme precipitation rates occur more often over land than over ocean. The challenges in the retrieval of extreme precipitation might be from the attenuation correction and large uncertainties in the Z-R relationships from near-surface radar reflectivity to precipitation rates. These potential uncertainties are examined by using collocated ground based radar reflectivity and precipitation retrievals.

Higher order magnetic modulation structures in rare earth metal, alloys and compounds under extreme conditions

International Nuclear Information System (INIS)

Kawano, S.

2003-01-01

Magnetic materials consisting of rare earth ions form modulation structures such as a helical or sinusoidal structure caused by the oscillating magnetic interaction between rare earth ions due to RKKY magnetic interaction. These modulation structures, in some cases, develop further to higher order modulation structures by additional modulations caused by higher order crystalline electric field, magnetic interactions such as spin-lattice interaction, external magnetic field and pressure. The higher order modulation structures are observed in a spin-slip structure or a helifan structure in Ho, and a tilt helix structure in a TbEr alloy. Paramagnetic ions originated from frustration generate many magnetic phases under applied external magnetic field. KUR neutron diffraction groups have performed the development and adjustment of high-pressure instruments and external magnetic fields for neutron diffraction spectrometers. The studies of 'neutron diffraction under extreme conditions' by the seven groups are described in this report. (Y. Kazumata)

Calculations of the magnetic properties of R{sub 2}M{sub 14}B intermetallic compounds (R=rare earth, M=Fe, Co)

Energy Technology Data Exchange (ETDEWEB)

Ito, Masaaki, E-mail: masaaki.ito@neel.cnrs.fr [CNRS, Institut Néel, 25 rue des Martyrs, BP166, 38042 Grenoble (France); University Grenoble Alpes, Institut Néel, 38042 Grenoble (France); Advanced Material Engineering Division, Toyota Motor Corporation, Susono 410-1193 (Japan); Yano, Masao [Advanced Material Engineering Division, Toyota Motor Corporation, Susono 410-1193 (Japan); Dempsey, Nora M. [CNRS, Institut Néel, 25 rue des Martyrs, BP166, 38042 Grenoble (France); University Grenoble Alpes, Institut Néel, 38042 Grenoble (France); Givord, Dominique [CNRS, Institut Néel, 25 rue des Martyrs, BP166, 38042 Grenoble (France); University Grenoble Alpes, Institut Néel, 38042 Grenoble (France); Instituto de Fisica, Universidade Federal do Rio de Janeiro, Rio de Janeiro (Brazil)

2016-02-15

The hard magnetic properties of “R–M–B” (R=rare earth, M=mainly Fe) magnets derive from the specific intrinsic magnetic properties encountered in Fe-rich R{sub 2}M{sub 14}B compounds. Exchange interactions are dominated by the 3d elements, Fe and Co, and may be modeled at the macroscopic scale with good accuracy. Based on classical formulae that relate the anisotropy coefficients to the crystalline electric field parameters and exchange interactions, a simple numerical approach is used to derive the temperature dependence of anisotropy in various R{sub 2}Fe{sub 14}B compounds (R=Pr, Nd, Dy). Remarkably, a unique set of crystal field parameters give fair agreement with the experimentally measured properties of all compounds. This implies reciprocally that the properties of compounds that incorporate a mixture of different rare-earth elements may be predicted accurately. This is of special interest for material optimization that often involves the partial replacement of Nd with another R element and also the substitution of Co for Fe. - Highlights: • Anisotropy constants derived from CEF parameters of R{sub 2}M{sub 14}B compounds (M=Fe, Co). • Anisotropy constants of all R{sub 2}Fe{sub 14}B compounds using unique set of CEF parameters. • Moment non-collinearity in magnetization processes under B{sub app} along hard axis.

On the entropy of four-dimensional near-extremal N = 2 black holes with R2-terms

International Nuclear Information System (INIS)

Gruss, Eyal; Oz, Yaron

2007-01-01

We consider the entropy of four-dimensional near-extremal N = 2 black holes. The Bekenstein-Hawking entropy formula has the structure of the extremal black holes entropy with a shift of the charges depending on the non-extremality parameter and the moduli at infinity. We construct a class of near-extremal horizon solutions with R 2 -terms, and show that the generalized Wald entropy formula exhibits the same property

Using iPods[R] and iPads[R] in Teaching Programs for Individuals with Developmental Disabilities: A Systematic Review

Science.gov (United States)

Kagohara, Debora M.; van der Meer, Larah; Ramdoss, Sathiyaprakash; O'Reilly, Mark F.; Lancioni, Giulio E.; Davis, Tonya N.; Rispoli, Mandy; Lang, Russell; Marschik, Peter B.; Sutherland, Dean; Green, Vanessa A.; Sigafoos, Jeff

2013-01-01

We conducted a systematic review of studies that involved iPods[R], iPads[R], and related devices (e.g., iPhones[R]) in teaching programs for individuals with developmental disabilities. The search yielded 15 studies covering five domains: (a) academic, (b) communication, (c) employment, (d) leisure, and (e) transitioning across school settings.…

Absence of a space-charge-derived enhancement of ionic conductivity in β|γ- heterostructured 7H- and 9R-AgI

International Nuclear Information System (INIS)

Morgan, B J; Madden, P A

2012-01-01

Extreme room temperature conductivity enhancements have been reported for nanocrystalline AgI of up to × 10 4 relative to bulk β-AgI (Guo et al 2005 Adv. Mater. 17 2815-9). These samples were identified as possessing 7H and 9R polytype structures, which can be considered as heterostructures composed of thin, commensurate layers in the β (wurtzite) and γ (zincblende) phases. It has been proposed that space-charge layer formation at β|γ-interfaces causes near complete disordering of the Ag + sublattice in these polytypes, resulting in a massive intrinsic enhancement of ionic conductivity. We have performed molecular dynamics simulations of β- and γ-AgI and mixed β|γ superlattices, to study the effect of heterostructuring on intrinsic defect populations and Ag + transport. The ionic conductivities and Ag + diffusion coefficients vary as β > 7H ≈ 9R ≈ 10L > γ. The β|γ-heterostructured polytypes show no enhancement in defect populations or Ag + mobilities relative to the β-AgI phase, and instead behave as simple composites of β- and γ-AgI. This contradicts the proposal that the extreme conductivity enhancement observed for 7H and 9R polytypes is explained by extensive space-charge formation. (paper)

~ i t i d e r m a t o ~ h ~ t i c Activities of Nine (9) Essential Oils J.R. ...

African Journals Online (AJOL)

i t i d e r m a t o ~ h ~ t i c Activities of Nine (9) Essential Oils. J.R. KUIATE", S.P. KUATE'.~, N.E. KEMADJOU~, S. DJOKOUA~, F. ZIFACK~ AND J. ~. 0. ~. 0. ~. I Department of Biochemistry, FS, University of Dschang, P.O. Box 67 Dschang, Cameroon. 2~epartment of Biochemistry, FS, University of Yaoundt!, P.O. Box 812 ...

Check List of Symptoms SCL - 90 - R at Persons with Extremities Amputations

Directory of Open Access Journals (Sweden)

Suada Kapidžić-Duraković

2006-02-01

Full Text Available Multidimensional Inventory Check List of Symptoms (SCL-90-r is based on self-evaluation and it has been used for determination of level of: somatisation, obsessive-compulsive symptoms, interpersonal sensitivity, depression, anxiety, hostility, phobias, paranoia and psychosis at persons which are exposed to long term emotional and physical stress. Our goal was to determine relations of physical trauma and psychological changes at persons with lower extremities amputations and to determine factors which influence those changes. Thirty seven persons with lower extremities amputations were examined. The sample included 26 (70.2 % veterans and 11 (29.7 % civilians with diseases related amputations. They voluntarily filled Check List of Symptoms SCL-90-r. Symptoms Inventory includes 9 dimensions of primary symptoms: SCL1-somatisation, SCL2-obsessive-compulsive symptoms, SCL3-interpersonal sensitivity, SCL4-depression, SCL5-anxiety, SCL6-hostility, SCL7-phobias, SCL8-paranoia, SCL9-psychosis and SCL10-extra scale. Inventory includes 90 statements, each evaluated with five-level scale of disorder. Every answer is graded with 0-4 points. Thirty seven persons with lower extremities amputations and average chronological age 46.2 +/- 10.92 years were analyzed. Considering marital status 30 (81.1 % of them were married, 4 (10.8 % were not married and 3 (8.1 % were widowers. Considering level of amputation 27 of them (73.0 % had amputation below knee, 5 (13.5 % of them amputation above knee and 5 of them (13.5 % foot amputation. SCL-90-r in both groups determined high level of sensitivity, anxiety, hostility and paranoia. Veterans showed higher level of paranoia comparing to civilians (p<0.002, and younger veterans and married ones had higher level of paranoia comparing to other veterans (p<0.01. Persons with amputations below and above knee showed higher level of paranoia comparing those with foot amputation (p<0.001. Persons with lower extremities

Exome sequencing in schizophrenic patients with high levels of homozygosity identifies novel and extremely rare mutations in the GABA/glutamatergic pathways.

Directory of Open Access Journals (Sweden)

Edoardo Giacopuzzi

Full Text Available Inbreeding is a known risk factor for recessive Mendelian diseases and previous studies have suggested that it could also play a role in complex disorders, such as psychiatric diseases. Recent inbreeding results in the presence of long runs of homozygosity (ROHs along the genome, which are also defined as autozygosity regions. Genetic variants in these regions have two alleles that are identical by descent, thus increasing the odds of bearing rare recessive deleterious mutations due to a homozygous state. A recent study showed a suggestive enrichment of long ROHs in schizophrenic patients, suggesting that recent inbreeding could play a role in the disease. To better understand the impact of autozygosity on schizophrenia risk, we selected, from a cohort of 180 Italian patients, seven subjects with extremely high numbers of large ROHs that were likely due to recent inbreeding and characterized the mutational landscape within their ROHs using Whole Exome Sequencing and, gene set enrichment analysis. We identified a significant overlap (17%; empirical p-value = 0.0171 between genes inside ROHs affected by low frequency functional homozygous variants (107 genes and the group of most promising candidate genes mutated in schizophrenia. Moreover, in four patients, we identified novel and extremely rare damaging mutations in the genes involved in neurodevelopment (MEGF8 and in GABA/glutamatergic synaptic transmission (GAD1, FMN1, ANO2. These results provide insights into the contribution of rare recessive mutations and inbreeding as risk factors for schizophrenia. ROHs that are likely due to recent inbreeding harbor a combination of predisposing low-frequency variants and extremely rare variants that have a high impact on pivotal biological pathways implicated in the disease. In addition, this study confirms that focusing on patients with high levels of homozygosity could be a useful prioritization strategy for discovering new high-impact mutations in

Exome sequencing in schizophrenic patients with high levels of homozygosity identifies novel and extremely rare mutations in the GABA/glutamatergic pathways.

Science.gov (United States)

Giacopuzzi, Edoardo; Gennarelli, Massimo; Minelli, Alessandra; Gardella, Rita; Valsecchi, Paolo; Traversa, Michele; Bonvicini, Cristian; Vita, Antonio; Sacchetti, Emilio; Magri, Chiara

2017-01-01

Inbreeding is a known risk factor for recessive Mendelian diseases and previous studies have suggested that it could also play a role in complex disorders, such as psychiatric diseases. Recent inbreeding results in the presence of long runs of homozygosity (ROHs) along the genome, which are also defined as autozygosity regions. Genetic variants in these regions have two alleles that are identical by descent, thus increasing the odds of bearing rare recessive deleterious mutations due to a homozygous state. A recent study showed a suggestive enrichment of long ROHs in schizophrenic patients, suggesting that recent inbreeding could play a role in the disease. To better understand the impact of autozygosity on schizophrenia risk, we selected, from a cohort of 180 Italian patients, seven subjects with extremely high numbers of large ROHs that were likely due to recent inbreeding and characterized the mutational landscape within their ROHs using Whole Exome Sequencing and, gene set enrichment analysis. We identified a significant overlap (17%; empirical p-value = 0.0171) between genes inside ROHs affected by low frequency functional homozygous variants (107 genes) and the group of most promising candidate genes mutated in schizophrenia. Moreover, in four patients, we identified novel and extremely rare damaging mutations in the genes involved in neurodevelopment (MEGF8) and in GABA/glutamatergic synaptic transmission (GAD1, FMN1, ANO2). These results provide insights into the contribution of rare recessive mutations and inbreeding as risk factors for schizophrenia. ROHs that are likely due to recent inbreeding harbor a combination of predisposing low-frequency variants and extremely rare variants that have a high impact on pivotal biological pathways implicated in the disease. In addition, this study confirms that focusing on patients with high levels of homozygosity could be a useful prioritization strategy for discovering new high-impact mutations in genetically

Robust flat bands in RCo5 (R=rare earth) compounds

OpenAIRE

Ochi, Masayuki; Arita, Ryotaro; Matsumoto, Munehisa; Kino, Hiori; Miyake, Takashi

2014-01-01

The mechanism to realize the peculiar flat bands generally existing in RCo5 (R=rare earth) compounds is clarified by analyzing the first-principles band structures and the tight-binding model. These flat bands are constructed from the localized eigenstates, the existence of which is guaranteed by the partial cancelation between the intersite hopping amplitudes among the Co-3d states at the Kagome sites and those between the Kagome and honeycomb sites. Their relative positions to other bands c...

The industry of metallic rare earths (R.E.)

International Nuclear Information System (INIS)

Poirier, P.

1979-01-01

The following subjects are discussed: rare earths resources (rare earths abondance and world reserves, main ores). Rare earths separation and purification (ionic exchange, solvent extraction). Metallic rare earths and their mixtures, metallothermic reduction of oxides or fluorides (Ca, Mg, Al, Si or rare earth metals), Co-reduction process for intermetallic compounds (SmCo 5 ). Industrial applications of metallic rare earths (traditional applications such as flints, nodular cast iron, steel refining, magnesium industrie, applications under development such as rare earths/cobalt magnets, LaNi 5 for hydrogen storage, special alloys (automotive post combustion), magnetostrictive alloys). Economical problems: rare earth are elements relatively abundant and often at easily accessible prices. However, this group of 15 elements are liable to certain economical restraints. It is difficult to crack ore for only one rare earth. Availability of one given rare earth must be associated with the other corresponding rare earths to absorb all the other rare earths in other applications. Rare-earth industry has a strong expanding rate. 20% per year average for 6 years with Rhone-Poulenc. Thanks to their exceptional, specific characteristics rare earths have a bright future particularly for their metals

Arterial tortuosity syndrome: An extremely rare disease presenting as a mimic of pulmonary sling

Directory of Open Access Journals (Sweden)

Amy Farkas, MD

2018-02-01

Full Text Available Pulmonary sling is the anatomic variant defined by the aberrant origin of the left pulmonary artery from the right pulmonary artery. This patient presented with a mimic of pulmonary sling as a result of an extremely rare condition, arterial tortuosity syndrome (ATS. The patient was first diagnosed with pulmonary sling on prenatal echocardiogram performed by cardiology. Computed tomography angiography of the chest obtained at birth to evaluate respiratory depression demonstrated ATS. The early detection of ATS has been demonstrated to improve patient outcome. This case provides an overview of the typical imaging features of ATS to aid radiologists in making this uncommon diagnosis.

Characterization and prediction of extreme events in turbulence

Science.gov (United States)

Fonda, Enrico; Iyer, Kartik P.; Sreenivasan, Katepalli R.

2017-11-01

Extreme events in Nature such as tornadoes, large floods and strong earthquakes are rare but can have devastating consequences. The predictability of these events is very limited at present. Extreme events in turbulence are the very large events in small scales that are intermittent in character. We examine events in energy dissipation rate and enstrophy which are several tens to hundreds to thousands of times the mean value. To this end we use our DNS database of homogeneous and isotropic turbulence with Taylor Reynolds numbers spanning a decade, computed with different small scale resolutions and different box sizes, and study the predictability of these events using machine learning. We start with an aggressive data augmentation to virtually increase the number of these rare events by two orders of magnitude and train a deep convolutional neural network to predict their occurrence in an independent data set. The goal of the work is to explore whether extreme events can be predicted with greater assurance than can be done by conventional methods (e.g., D.A. Donzis & K.R. Sreenivasan, J. Fluid Mech. 647, 13-26, 2010).

Oligomeric rare-earth metal cluster complexes with endohedral transition metal atoms

Energy Technology Data Exchange (ETDEWEB)

Steinberg, Simon; Zimmermann, Sina; Brühmann, Matthias; Meyer, Eva; Rustige, Christian; Wolberg, Marike; Daub, Kathrin; Bell, Thomas; Meyer, Gerd, E-mail: gerd.meyer@uni-koeln.de

2014-11-15

Comproportionation reactions of rare-earth metal trihalides (RX{sub 3}) with the respective rare-earth metals (R) and transition metals (T) led to the formation of 22 oligomeric R cluster halides encapsulating T, in 19 cases for the first time. The structures of these compounds were determined by single-crystal X-ray diffraction and are composed of trimers ((T{sub 3}R{sub 11})X{sub 15}-type, P6{sub 3}/m), tetramers ((T{sub 4}R{sub 16})X{sub 28}(R{sub 4}) (P-43m), (T{sub 4}R{sub 16})X{sub 20} (P4{sub 2}/nnm), (T{sub 4}R{sub 16})X{sub 24}(RX{sub 3}){sub 4} (I4{sub 1}/a) and (T{sub 4}R{sub 16})X{sub 23} (C2/m) types of structure) and pentamers ((Ru{sub 5}La{sub 14}){sub 2}Br{sub 39}, Cc) of (TR{sub r}){sub n} (n=2–5) clusters. These oligomers are further enveloped by inner (X{sup i}) as well as outer (X{sup a}) halido ligands, which possess diverse functionalities and interconnect like oligomers through i–i, i–a and/or a–i bridges. The general features of the crystal structures for these new compounds are discussed and compared to literature entries as well as different structure types with oligomeric T centered R clusters. Dimers and tetramers originating from the aggregation of (TR{sub 6}) octahedra via common edges are more frequent than trimers and pentamers, in which the (TR{sub r}) clusters share common faces. - Graphical abstract: Rare earth-metal cluster complexes with endohedral transition metal atoms (TR{sub 6}) may connect via common edges or faces to form dimers, trimers, tetramers and pentamers of which the tetramers are the most prolific. Packing effects and electron counts play an important role. - Highlights: • Rare-earth metal cluster complexes encapsulate transition metal atoms. • Oligomers are built via connection of octahedral clusters via common edges or faces. • Dimers through pentamers with closed structures are known. • Tetramers including a tetrahedron of endohedral atoms are the most prolific.

Structural, optical and spectroscopical investigations into rare-earths perowskites RGaO3 (R=La, Pr, Nd) and NdBa-2Cu3O7-δ

International Nuclear Information System (INIS)

Marti, W.

1995-07-01

In this work I was engaged in rare-earth perovskites. Primarily I investigated the structure of the rare-earth gallates RGaO 3 (R=La, Pr, Nd) as a function of the temperature by means of neutron diffraction and x-ray diffraction. As the high-T c superconductors these compounds belong to the family of the perovskites, they are ferroelastic and centro-symmetric. Because of the lanthanide-contraction all lattice constants and distortion parameters change systematically. The rare-earth-gallates RGaO 3 (R=La, Pr, Nd) are promising substrates for epitaxy of high-T c superconductors like RBa 2 Cu 3 OO 7-δ because of their structure parameters and expansion coefficients. I succeeded in producing plane-parallel single-domain crystals by means of uniaxial stress. The first order phase transition was observable only in LaGaO 3 . A structurally phase transition from orthorhombic to rhombohedral symmetry (high-temperature phase) occurs at 423 K. The hysteresis of the phase transition temperature of about 1.5 K was measured with single-domain crystals by means of neutron diffraction and polarized light microscopy. In NdGaO 3 we determined the long-range, three-dimensional, antiferromagnetic ordering of the Nd 3+ -ions below the ordering temperature at T N =0.97 K by means of magnetic neutron diffraction. The spin configuration could be described by a (--c z )-mode. Measurements of the magnetic susceptibility confirm the easy direction of magnetization to be the c-axis. Below 300mK an additional nuclear spin polarization due to the hyperfine-interaction appears parallel to the electronic spins, which amounts to 70% at 10mK. Further I investigated the optical properties of the rare-earth gallates. The birefringence of plane-parallel, polished single-domain crystals with thickness up to 300 μm was measured by means of orthoscopy and conoscopy. (author) figs., tabs., refs

DISCOVERY OF BRIGHT GALACTIC R CORONAE BOREALIS AND DY PERSEI VARIABLES: RARE GEMS MINED FROM ACVS

International Nuclear Information System (INIS)

Miller, A. A.; Richards, J. W.; Bloom, J. S.; Cenko, S. B.; Silverman, J. M.; Starr, D. L.; Stassun, K. G.

2012-01-01

We present the results of a machine-learning (ML)-based search for new R Coronae Borealis (RCB) stars and DY Persei-like stars (DYPers) in the Galaxy using cataloged light curves from the All-Sky Automated Survey (ASAS) Catalog of Variable Stars (ACVS). RCB stars—a rare class of hydrogen-deficient carbon-rich supergiants—are of great interest owing to the insights they can provide on the late stages of stellar evolution. DYPers are possibly the low-temperature, low-luminosity analogs to the RCB phenomenon, though additional examples are needed to fully establish this connection. While RCB stars and DYPers are traditionally identified by epochs of extreme dimming that occur without regularity, the ML search framework more fully captures the richness and diversity of their photometric behavior. We demonstrate that our ML method can use newly discovered RCB stars to identify additional candidates within the same data set. Our search yields 15 candidates that we consider likely RCB stars/DYPers: new spectroscopic observations confirm that four of these candidates are RCB stars and four are DYPers. Our discovery of four new DYPers increases the number of known Galactic DYPers from two to six; noteworthy is that one of the new DYPers has a measured parallax and is m ≈ 7 mag, making it the brightest known DYPer to date. Future observations of these new DYPers should prove instrumental in establishing the RCB connection. We consider these results, derived from a machine-learned probabilistic classification catalog, as an important proof-of-concept for the efficient discovery of rare sources with time-domain surveys.

Investigation of the existence and uniqueness of extremal and positive definite solutions of nonlinear matrix equations

Directory of Open Access Journals (Sweden)

Abdel-Shakoor M Sarhan

2016-05-01

Full Text Available Abstract We consider two nonlinear matrix equations X r ± ∑ i = 1 m A i ∗ X δ i A i = I $X^{r} \\pm \\sum_{i = 1}^{m} A_{i}^{*}X^{\\delta_{i}}A_{i} = I$ , where − 1 < δ i < 0 $- 1 < \\delta_{i} < 0$ , and r, m are positive integers. For the first equation (plus case, we prove the existence of positive definite solutions and extremal solutions. Two algorithms and proofs of their convergence to the extremal positive definite solutions are constructed. For the second equation (negative case, we prove the existence and the uniqueness of a positive definite solution. Moreover, the algorithm given in (Duan et al. in Linear Algebra Appl. 429:110-121, 2008 (actually, in (Shi et al. in Linear Multilinear Algebra 52:1-15, 2004 for r = 1 $r = 1$ is proved to be valid for any r. Numerical examples are given to illustrate the performance and effectiveness of all the constructed algorithms. In Appendix, we analyze the ordering on the positive cone P ( n ‾ $\\overline{P(n}$ .

Eksplosion i rådnetank med biogas

DEFF Research Database (Denmark)

Hedlund, Frank Huess

2015-01-01

En rådnetank på Vejle Centralrenseanlæg eksploderede i 1990, mens håndværkere arbejdede på taget. Nu, 24 år senere, hvor biogas er populært som aldrig før, er hændelsen fuldstændig forsvundet fra tilgængelige åbne kilder.......En rådnetank på Vejle Centralrenseanlæg eksploderede i 1990, mens håndværkere arbejdede på taget. Nu, 24 år senere, hvor biogas er populært som aldrig før, er hændelsen fuldstændig forsvundet fra tilgængelige åbne kilder....

Eksplosion i rådnetank med biogas

DEFF Research Database (Denmark)

Hedlund, Frank Huess

2014-01-01

En rådnetank på Vejle Centralrenseanlæg eksploderede i 1990, mens håndværkere arbejdede på taget. Nu, 24 år senere, hvor biogas er populært som aldrig før, er hændelsen fuldstændig forsvundet fra tilgængelige åbne kilder.......En rådnetank på Vejle Centralrenseanlæg eksploderede i 1990, mens håndværkere arbejdede på taget. Nu, 24 år senere, hvor biogas er populært som aldrig før, er hændelsen fuldstændig forsvundet fra tilgængelige åbne kilder....

I Zarathustras spår

DEFF Research Database (Denmark)

Nordenfors, Ola

2006-01-01

Uppsatsen behandlar Wilhelm Peterson-Bergers djupa och varaktiga förhållande till Friedrich Nietzsches tänkande; särskilt sångerna till Nietzsche-texter. Vidare demonstreras hur P.-B.:s musikaliska uttryckssätt förändras i kontakt med Nietzsches dikter.......Uppsatsen behandlar Wilhelm Peterson-Bergers djupa och varaktiga förhållande till Friedrich Nietzsches tänkande; särskilt sångerna till Nietzsche-texter. Vidare demonstreras hur P.-B.:s musikaliska uttryckssätt förändras i kontakt med Nietzsches dikter....

Andelsboligforeningslovens § 4 og vilkår i lejeforhold, der stiftes i medfør af bestemmelsen

DEFF Research Database (Denmark)

Graven Nielsen, Kristian; Edlund, Hans Henrik

2013-01-01

Sælges en andelsboligforenings ejendom, har de hidtidige andelshavere efter andelsboligforeningslovens § 4, stk. 1, ret til fortsat brugsret som lejere. I artiklen redegøres for det nærmere indhold af den retsstilling, som bestemmelsen i andelsboligforeningsloven hjemler, herunder især med hensyn...... lejelovgivningens præceptive og deklaratoriske regler, medmindre den ny ejer kan opnå lejerens accept af andre vilkår....

R.E.S.E.X. A computer simulation program for rare earth separation processes

International Nuclear Information System (INIS)

Casarci, M.; Gasparini, G.M.; Sanfilippo, L; Pozio, A.

1996-01-01

Lanthanides are most commonly separated using complex solvent extraction circuits. A simulation code has been developed by E.N.E.A. called R.E.S.E.X. (Rare Earth Solvent Extraction) which is able to simulate a solvent extraction battery up to 200 stages, using different configurations. The contemporary utilisation of an equilibrium data bank and of a simulation code allows the theoretical study of new rare earth separative processes or the optimisation of existing ones. As an example of this strategy are reported the results of the Pr/Nd separation in TBP 50 % in aromatic solvent

Crystal-fields at rare-earth sites in R2Fe14B compounds

International Nuclear Information System (INIS)

Adam, S.; Adam, G.; Burzo, E.

1985-12-01

Crystal-field effects are expected to be important in R 2 Fe 14 B compounds. Within a model-independent approach, it is proved that four distinct rare-earth sites exist with respect to the crystalline electric fields, namely, R(4f; z=0), R(4f; z=0.5 c), R(4g; z=0), and R(4g; z=0.5 c), and relationships are established between the corresponding crystal-fields coefficients. Further, generalized Stevens parametrizations of the crystal field coefficients are derived at three levels of approximation for the interatomic forces inside the crystal. A crystal lattice dressing effect upon the radial electronic integrals is found to occur, the magnitude of which depends on the deviation of the interatomic forces from Coulombian. Finally, computation of crystal-field coefficients in Nd 2 Fe 14 B leads to results which raise questions about the validity of the simple Coulomb point-charge model. (author)

Bör Barnkonventionen bli lag i Sverige? : En komparativrättslig studie om barnets rättigheter i Sverige och Norge.

OpenAIRE

Hedman, Wendela

2014-01-01

Abstrakt ”Bör barnkonventionen bli lag i Sverige? – En komparativrätts-lig studie on barnets rättigheter genom barnkonventionen i Sverige & Norge” Uppsatsen diskuterar med en komparativrättslig metodik implementeringen och inkorporering av barnkonventionen i Sverige och Norge. I tre steg ämnar uppsatsen att undersöka huruvida barnkonventionen bör implementeras till fullo och göras till svensk lag på samma sätt som Norge har valt att göra.Uppsatsen fokuserar på FN:s barnrättkommittés yttra...

Opgavebegrænsning i rådgivningsaftaler

DEFF Research Database (Denmark)

Munk-Hansen, Carsten

2010-01-01

Det undersøges, i hvilket omfang en erhvervsdrivende rådgivers opgaver kan begrænses ved aftale, og konkluderes, at udgangspunktet er aftalefrihed, når opgavebgrænsnigen er loyal over for kundens interesser, Antagelsen bryder med dele af juridisk teori. Det vil i almindelighed være af afgørende...

Overvågning af aviær influenza i vilde fugle i Danmark 2014

DEFF Research Database (Denmark)

Hjulsager, Charlotte Kristiane; Krog, Jesper Schak; Madsen, Jesper J.

Overvågningen af aviær influenza (AI) virus i vilde fugle i Danmark i 2014 blev udført i samarbejde mellem Veterinærinstituttet, Danmarks Tekniske Universitet (DTU-VET), Fødevarestyrelsen (FVST) og Statens Naturhistoriske Museum, Københavns Universitet (SNM) i henhold til ” Projektplan vedr....... overvågningen af aviær influenza i vilde fugle i Danmark i 2014” (bilag 4). Overvågning af AI på EU niveau går tilbage til 2002, og Danmark er underlagt EU kommissionens bestemmelser for udformning af overvågningen, der dog har skiftet gennem årene i takt med indhøstede erfaringer. I 2014 blev der udført passiv...

Kontaktlærers utfordringer når en elev i klassen dør

OpenAIRE

Nevland, Tiril

2014-01-01

I denne bacheloroppgaven har jeg valgt å skrive om prosessen i en klasse etter en elev i klassen dør, med kontaktlærers utfordringer i fokus. De fleste av oss vil kanskje aldri oppleve det, men hva gjør man om det skjer sin egen klasse? En pult står tom, og vi må som kontaktlærer klare å håndtere situasjonen på en profesjonell måte. Jeg ønsker å finne ut av hvilke utfordringer kontaktlærer kan møte etter en slik tragedie. Med det ønsker jeg å bli bedre forberedt dersom det skjer i min klasse....

Design og analyse af eksperimenter i R

DEFF Research Database (Denmark)

Dahl, Malte Rokkjær

2017-01-01

eksperimentelle studier med afsæt i statistikprogrammet R. Det er håbet, at notatet vil være en hjælp til at reflektere over, designe, og analysere eksperimenter i forbindelse med bachelorprojekter eller specialer - og forhåbentligt også i arbejde med eksperimenter uden for instituttets mure. Notatet berører......, herunder balancetest, hypotesetest med og uden kovariatjustering, interaktioner samt udledning af konfidensintervaller. Det antages, at læseren har et grundlæggende kendskab til R samt til *potentiel outcomes*-frameworket. De indledende kapitler i Gerber & Green (2012) eller Imbens & Athey (2017) er gode...

Udenlandske direkte investeringe r i Danmark

DEFF Research Database (Denmark)

Nielsen, Bo Bernhard; Geisler Asmussen, Christian; Weatherall, Cecilie Dohlmann

Udenlandske investeringer betragtes ofte som en vigtig kilde til viden, vækst og vær diskabende job, som spredes i den lokale økonomi via personlige netværk og mobilitet på arbejdsmarkedet. Hvordan disse udenlandske investeringer er place ret i forhold til de lokale rammebetingelser i land, by el...

SPET imaging of central muscarinic receptors with (R,R)[123I]-I-QNB: methodological considerations

International Nuclear Information System (INIS)

Norbury, R.; Travis, M.J.; Erlandsson, K.; Waddington, W.; Owens, J.; Ell, P.J.; Murphy, D.G.

2004-01-01

Investigations on the effect of normal healthy ageing on the muscarinic system have shown conflicting results. Also, in vivo determination of muscarinic receptor binding has been hampered by a lack of subtype selective ligands and differences in methods used for quantification of receptor densities. Recent in vitro and in vivo work with the muscarinic antagonist (R,R)-I-QNB indicates this ligand has selectivity for m 1 and m 4 muscarinic receptor subtypes. Therefore, we used (R,R)[ 123 I]-I-QNB and single photon emission tomography to study brain m 1 and m 4 muscarinic receptors in 25 healthy female subjects (11 younger subjects, age range 26-32 years and 14 older subjects, age range 57-82 years). Our aims were to ascertain the viability of tracer administration and imaging within the same day, and to evaluate whether normalization to whole brain, compared to normalization to cerebellum, could alter the clinical interpretation of results. Images were analyzed using the simplified reference tissue model and by two ratio methods: normalization to whole brain and normalization to cerebellum. Significant correlations were observed between kinetic analysis and normalization to cerebellum, but not to whole brain. Both the kinetic analysis and normalization to cerebellum showed age-related reductions in muscarinic binding in frontal, orbitofrontal, and parietal regions. Normalization to whole brain, however, failed to detect age-related changes in any region. Here we show that, for this radiotracer, normalizing to a region of negligible specific binding (cerebellum) significantly improves sensitivity when compared to global normalization

Sintered cobalt-rare earth intermetallic product

International Nuclear Information System (INIS)

Benz, M.C.

1975-01-01

A process is described for preparing novel sintered cobalt--rare earth intermetallic products which can be magnetized to form permanent magnets having stable improved magnetic properties. A cobalt--rare earth metal alloy is formed having a composition which at sintering temperature falls outside the composition covered by the single Co 5 R intermetallic phase on the rare earth richer side. The alloy contains a major amount of the Co 5 R intermetallic phase and a second solid CoR phase which is richer in rare earth metal content than the Co 5 R phase. The specific cobalt and rare earth metal content of the alloy is substantially the same as that desired in the sintered product. The alloy, in particulate form, is pressed into compacts and sintered to the desired density. The sintered product is comprised of a major amount of the Co 5 R solid intermetallic phase and up to about 35 percent of the product of the second solid CoR intermetallic phase which is richer in rare earth metal content than the Co 5 R phase

Når vi går i drift

DEFF Research Database (Denmark)

Svejvig, Per

2012-01-01

Implementering af store forretningssystemer til CRM og ERP optager mange danske virksomheder. Denne artikel fokuserer på forandringsledelse som en meget vigtig og integreret del af den samlede implementering. Artiklen berører især tiden efter at man er gået i drift med forretningssystemet....

KONTROLÖR ALAN AĞI ESASLI BİR ATM ALAN TAŞITININ TASARLANMASI

Directory of Open Access Journals (Sweden)

Mahmut TENRUH

2006-03-01

Full Text Available Kontrolör Alan Ağı (KAA taşıtı başlangıçta otomotiv uygulamaları için önerilmiş fakat düşük maliyeti yüksek hızı ve güvenilirliği sayesinde endüstriyel dağılımlı gerçek zamanlı kontrol uygulamalarında da bir standart haline gelmiştir. ATM veri, ses ve görüntü gibi tüm haberleşme türlerini bir network yapısı içerisinde birleştirmeyi hedefleyen hızlı bir ağ teknolojisidir. Ethernet ve Token Ring gibi mevcut ağ türlerinin ATM ile bağlanması için çeşitli çalışmalar sürdürülmüştür. Kontrol Taşıtı haberleşmesinin de bu çerçevede ele alınması önem taşımaktadır. Bu çalışma ATM teknolojisinin Kontrol Taşıtı haberleşmesi ile birlikte kullanılmasını amaçlamaktadır. Bu kapsamda KAA esaslı ATM Taşıt yapısı sunulmaktadır. Bu yapı aynı zamanda Kontrol Taşıt ağlarının ATM ağları ile doğrudan bağlanabilmesi için de bir imkan sunmaktadır. Önerilen modelin geçerliliğini görmek amacıyla simülasyon çalışmaları yürütülmüş ve sonuçlar sistemin ek avantajlarla uygulanabilir olduğunu göstermiştir.

Implications of extreme flatness in a general f(R theory

Directory of Open Access Journals (Sweden)

Michał Artymowski

2016-09-01

Full Text Available We discuss a modified gravity theory defined by f(R=∑nlαnM2(1−nRn. We consider both finite and infinite number of terms in the series while requiring that the Einstein frame potential of the theory has a flat area around any of its stationary points. We show that the requirement of maximally flat stationary point leads to the existence of the saddle point (local maximum for even (odd l. In both cases for l→∞ one obtains the Starobinsky model with small, exponentially suppressed corrections. Besides the GR minimum the Einstein frame potential has an anti de Sitter vacuum. However we argue that the GR vacuum is absolutely stable and AdS can be reached neither via classical evolution nor via quantum tunnelling. Our results show that a Starobinsky-like model is the only possible realisation of f(R theory with an extremely flat area in the Einstein frame potential.

Determination of LongR3-IGF-I, R3-IGF-I, Des1-3 IGF-I and their metabolites in human plasma samples by means of LC-MS.

Science.gov (United States)

Thomas, Andreas; Walpurgis, Katja; Delahaut, Philippe; Fichant, Eric; Schänzer, Wilhelm; Thevis, Mario

2017-08-01

According to the regulations of the World Anti-Doping Agency (WADA), growth promoting peptides such as the insulin-like growth factor-I (IGF-I) and its synthetic analogues belong to the class of prohibited compounds. While several assays to quantify endogenous IGF-I have been established, the potential misuse of synthetic analogues such as LongR 3 -IGF-I, R 3 -IGF-I and Des1-3-IGF-I remains a challenge and superior pharmacokinetic properties have been described for these analogues. Within the present study, it was demonstrated that the target peptides can be successfully detected in plasma samples by means of magnetic beads-based immunoaffinity purification and subsequent nanoscale liquid chromatographic separation with high resolution mass spectrometric detection. Noteworthy, the usage of a specific antibody for LongR 3 -IGF-I enables the determination in low ng/mL levels despite the presence of an enormous excess of endogenous human IGF-I. In addition, different metabolism studies (in-vitro and in-vivo) were performed using sophisticated strategies such as incubation with skin tissue microsomes, degradation in biological fluids (for all analogues), and administration to rats (for LongR 3 -IGF-I). Herewith, several C-and N-terminally truncated metabolites were identified and their relevancy was additionally confirmed by in-vivo experiments with rodents. Especially for LongR 3 -IGF-I, a metabolite ((Des1-11)-LongR 3 -IGF-I) was identified that prolonged the detectability in-vivo by a factor of approximately 2. The method was validated for qualitative interpretation considering the parameters specificity, identification capability, recovery (26-60%), limit of detection (0.5ng/mL), imprecision (IGF-I was used as internal standard to control all sample preparation steps. Copyright © 2017 Elsevier Ltd. All rights reserved.

Rare earth metals, rare earth hydrides, and rare earth oxides as thin films

International Nuclear Information System (INIS)

Gasgnier, M.

1980-01-01

The review deals with pure rare earth materials such as rare earth metals, rare earth hydrides, and rare earth oxides as thin films. Several preparation techniques, control methods, and nature of possible contaminations of thin films are described. These films can now be produced in an extremely well-known state concerning chemical composition, structure and texture. Structural, electric, magnetic, and optical properties of thin films are studied and discussed in comparison with the bulk state. The greatest contamination of metallic rare earth thin films is caused by reaction with hydrogen or with water vapour. The compound with an f.c.c. structure is the dihydride LnH 2 (Ln = lanthanides). The oxygen contamination takes place after annealing at higher temperatures. Then there appears a compound with a b.c.c. structure which is the C-type sesquioxide C-Ln 2 O 3 . At room atmosphere dihydride light rare earth thin films are converted to hydroxide Ln(OH) 3 . For heavy rare earth thin films the oxinitride LnNsub(x)Osub(y) is observed. The LnO-type compound was never seen. The present review tries to set the stage anew for the investigations to be undertaken in the future especially through the new generations of electron microscopes

Thermodynamics of extremal rotating thin shells in an extremal BTZ spacetime and the extremal black hole entropy

Science.gov (United States)

Lemos, José P. S.; Minamitsuji, Masato; Zaslavskii, Oleg B.

2017-02-01

In a (2 +1 )-dimensional spacetime with a negative cosmological constant, the thermodynamics and the entropy of an extremal rotating thin shell, i.e., an extremal rotating ring, are investigated. The outer and inner regions with respect to the shell are taken to be the Bañados-Teitelbom-Zanelli (BTZ) spacetime and the vacuum ground state anti-de Sitter spacetime, respectively. By applying the first law of thermodynamics to the extremal thin shell, one shows that the entropy of the shell is an arbitrary well-behaved function of the gravitational area A+ alone, S =S (A+). When the thin shell approaches its own gravitational radius r+ and turns into an extremal rotating BTZ black hole, it is found that the entropy of the spacetime remains such a function of A+, both when the local temperature of the shell at the gravitational radius is zero and nonzero. It is thus vindicated by this analysis that extremal black holes, here extremal BTZ black holes, have different properties from the corresponding nonextremal black holes, which have a definite entropy, the Bekenstein-Hawking entropy S (A+)=A/+4G , where G is the gravitational constant. It is argued that for extremal black holes, in particular for extremal BTZ black holes, one should set 0 ≤S (A+)≤A/+4G;i.e., the extremal black hole entropy has values in between zero and the maximum Bekenstein-Hawking entropy A/+4 G . Thus, rather than having just two entropies for extremal black holes, as previous results have debated, namely, 0 and A/+4 G , it is shown here that extremal black holes, in particular extremal BTZ black holes, may have a continuous range of entropies, limited by precisely those two entropies. Surely, the entropy that a particular extremal black hole picks must depend on past processes, notably on how it was formed. A remarkable relation between the third law of thermodynamics and the impossibility for a massive body to reach the velocity of light is also found. In addition, in the procedure, it

NEW RARE EARTH ELEMENT ABUNDANCE DISTRIBUTIONS FOR THE SUN AND FIVE r-PROCESS-RICH VERY METAL-POOR STARS

International Nuclear Information System (INIS)

Sneden, Christopher; Lawler, James E.; Den Hartog, Elizabeth A.; Cowan, John J.; Ivans, Inese I.

2009-01-01

We have derived new abundances of the rare earth elements Pr, Dy, Tm, Yb, and Lu for the solar photosphere and for five very metal-poor, neutron-capture r-process-rich giant stars. The photospheric values for all five elements are in good agreement with meteoritic abundances. For the low-metallicity sample, these abundances have been combined with new Ce abundances from a companion paper, and reconsideration of a few other elements in individual stars, to produce internally consistent Ba, rare earth, and Hf (56 ≤ Z ≤ 72) element distributions. These have been used in a critical comparison between stellar and solar r-process abundance mixes.

Regulatory role of XynR (YagI) in catabolism of xylonate in Escherichia coli K-12.

Science.gov (United States)

Shimada, Tomohiro; Momiyama, Eri; Yamanaka, Yuki; Watanabe, Hiroki; Yamamoto, Kaneyoshi; Ishihama, Akira

2017-12-01

The genome of Escherichia coli K-12 contains ten cryptic phages, altogether constituting about 3.6% of the genome in sequence. Among more than 200 predicted genes in these cryptic phages, 14 putative transcription factor (TF) genes exist, but their regulatory functions remain unidentified. As an initial attempt to make a breakthrough for understanding the regulatory roles of cryptic phage-encoded TFs, we tried to identify the regulatory function of CP4-6 cryptic prophage-encoded YagI with unknown function. After SELEX screening, YagI was found to bind mainly at a single site within the spacer of bidirectional transcription units, yagA (encoding another uncharacterized TF) and yagEF (encoding 2-keto-3-deoxy gluconate aldolase, and dehydratase, respectively) within this prophage region. YagEF enzymes are involved in the catabolism of xylose downstream from xylonate. We then designated YagI as XynR (regulator of xylonate catabolism), one of the rare single-target TFs. In agreement with this predicted regulatory function, the activity of XynR was suggested to be controlled by xylonate. Even though low-affinity binding sites of XynR were identified in the E. coli K-12 genome, they all were inside open reading frames, implying that the regulation network of XynR is still fixed within the CR4-6 prophage without significant influence over the host E. coli K-12. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Overvågning af aviær influenza i vilde fugle i Danmark 2013

DEFF Research Database (Denmark)

Hjulsager, Charlotte Kristiane; Krog, Jesper Schak; Madsen, Jesper J.

Overvågningen af aviær influenza (AI) virus i vilde fugle i Danmark i 2012 er udført i samarbejde mellem Fødevarestyrelsen (FVST), Veterinærinstituttet, Danmarks Tekniske Universitet (DTU-VET) og Statens Naturhistoriske Museum, Københavns Universitet (SNM) i henhold til ”Aftale mellem Fødevaresty......Overvågningen af aviær influenza (AI) virus i vilde fugle i Danmark i 2012 er udført i samarbejde mellem Fødevarestyrelsen (FVST), Veterinærinstituttet, Danmarks Tekniske Universitet (DTU-VET) og Statens Naturhistoriske Museum, Københavns Universitet (SNM) i henhold til ”Aftale mellem...... Fødevarestyrelsen og Veterinærinstituttet om overvågning af aviær influenza i vilde fugle i Danmark i 2012” (bilag 4). Overvågning af AI på EU niveau går tilbage til 2002, og Danmark er underlagt EU kommissionens bestemmelser for udformning af overvågningen, der dog har skiftet gennem årene i takt med indhøstede...... erfaringer. I 2012 blev der udført passiv overvågning af døde vilde fugle, der blev fundet i naturen på lokaliteter, der fordelte sig over det meste af landet. Der blev testet 18 fugle, og ingen af disse var positive for HPAI. To prøver var positive for LPAI virus, men disse virus var ikke af influenza A H5...

Overvågning af aviær influenza i vilde fugle 2012 i Danmark

DEFF Research Database (Denmark)

Hjulsager, Charlotte Kristiane; Trebbien, Ramona; Madsen, Jesper J.

Overvågningen af aviær influenza (AI) virus i vilde fugle i Danmark i 2012 er udført i samarbejde mellem Fødevarestyrelsen (FVST), Veterinærinstituttet, Danmarks Tekniske Universitet (DTU-VET) og Statens Naturhistoriske Museum, Københavns Universitet (SNM) i henhold til ”Aftale mellem Fødevaresty......Overvågningen af aviær influenza (AI) virus i vilde fugle i Danmark i 2012 er udført i samarbejde mellem Fødevarestyrelsen (FVST), Veterinærinstituttet, Danmarks Tekniske Universitet (DTU-VET) og Statens Naturhistoriske Museum, Københavns Universitet (SNM) i henhold til ”Aftale mellem...... Fødevarestyrelsen og Veterinærinstituttet om overvågning af aviær influenza i vilde fugle i Danmark i 2012” (bilag 4). Overvågning af AI på EU niveau går tilbage til 2002, og Danmark er underlagt EU kommissionens bestemmelser for udformning af overvågningen, der dog har skiftet gennem årene i takt med indhøstede...... erfaringer. I 2012 blev der udført passiv overvågning af døde vilde fugle, der blev fundet i naturen på lokaliteter, der fordelte sig over det meste af landet. Der blev testet 18 fugle, og ingen af disse var positive for HPAI. To prøver var positive for LPAI virus, men disse virus var ikke af influenza A H5...

Dansk sekretær i DAC

DEFF Research Database (Denmark)

Andersen, Jens Enevold Thaulov

2007-01-01

Danmark lå noget længere nede ad listen, hvad deltagere angår - på linie med Algeriet, Venezuela og Estland! Selvom Euroanalysis kongressen og DANSAK kongressen nu holdes i henholdsvis ulige og lige år, så var det alligevel kun de tre medlemmer af Analytikergruppen fra DTU, som repræsenterede Danmark. Det...

Pas på pastaen fra i går

DEFF Research Database (Denmark)

Abildgaard, Inger; Skibsted, Leif Horsfelt

2017-01-01

Der kan være bakterier i ris og pasta fra dagen før. En sporedannende bakterie kan vokse frem og danne giftstoffer, når de kogte ris eller den kogte pasta gemmes.......Der kan være bakterier i ris og pasta fra dagen før. En sporedannende bakterie kan vokse frem og danne giftstoffer, når de kogte ris eller den kogte pasta gemmes....

Thyroid Gland Metastasis from Cancer of the Uterine Cervix: An Extremely Rare Case Report.

Science.gov (United States)

Celik, Suleyman Utku; Besli, Dilara; Sak, Serpil Dizbay; Genc, Volkan

The thyroid gland is a relatively uncommon site for a metastatic disease, although it is richly supplied with blood. The metastases may originate from various primary sites, mainly kidney, lung, head and neck, and breast. Thyroid metastasis from cervical carcinomas is extremely rare; and only a few cases have been previously reported in the literature. In patient with thyroid nodules and an oncological history, the possibility of thyroid metastasis should be seriously considered. Despite the rarity of the metastasis of cervical carcinoma to the thyroid, it is difficult to say appropriate treatment approach for these lesions. When managing such patients, decision-making should balance the possibility of gaining long-term survival against estimation of the aggressiveness of the disease and its possible complications. Here, a case of thyroid metastasis from a squamous cell carcinoma of the uterine cervix presenting with cervical mass and difficulty in swallowing and its treatment is reported.

ISABELLE. Volume 4. Detector R and D

International Nuclear Information System (INIS)

1981-01-01

Workshop participants were asked to assess the current status of detector R and D in terms of the specific needs for ISABELLE experiments: the demands of high particle rates, extremely selective triggers on complex and rare events, and the economics of large detector systems. The detailed results of working groups convened to consider specific areas of detector development are presented. The key points of this assessment, as regards the continuing R and D program for ISABELLE are summarized here. Twenty-six items from the volume were prepared separately for the data base, along with five items previously prepared

ISABELLE. Volume 4. Detector R and D

Energy Technology Data Exchange (ETDEWEB)

1981-01-01

Workshop participants were asked to assess the current status of detector R and D in terms of the specific needs for ISABELLE experiments: the demands of high particle rates, extremely selective triggers on complex and rare events, and the economics of large detector systems. The detailed results of working groups convened to consider specific areas of detector development are presented. The key points of this assessment, as regards the continuing R and D program for ISABELLE are summarized here. Twenty-six items from the volume were prepared separately for the data base, along with five items previously prepared. (GHT)

Naturudnyttelse i det Færøske ø-samfund gennem tusind år - set i humanøkologisk perspektiv

DEFF Research Database (Denmark)

Brandt, Jesper

1988-01-01

Færøerne er på mange måde spændende og exotiske. Det er jo i sig selv en motivation til at studere dem. Men der er også nogle gode faglige grunde til at foretage geografiske og humanøkologiske studier af øerne. Den isolerede beliggenhed, de i hovedtrækkene typiske sammenhængende fysisk-geografisk......Færøerne er på mange måde spændende og exotiske. Det er jo i sig selv en motivation til at studere dem. Men der er også nogle gode faglige grunde til at foretage geografiske og humanøkologiske studier af øerne. Den isolerede beliggenhed, de i hovedtrækkene typiske sammenhængende fysisk...

Nærvær i pædagogisk praksis

DEFF Research Database (Denmark)

Nærvær i pædagogisk praksis handler om, hvordan lærere og pædagoger kan arbejde med mindfulness i skole og daginstitution. Målet er at give inspiration til, hvordan man kan skabe et lærings- og udviklingsmiljø, som understøtter en praksis, hvor børn får erfaringer med at være til stede i sig selv......, ligesom de giver eksempler på nærværende kunst- og musikundervisning.   Den røde tråd er ønsket om at bistå barnet i at rumme sig selv og andre og en interesse for de muligheder, som øget nærvær kan give det enkelte barn og fællesskabet....

Solitary plasmacytoma of the mandible - a rare entity.

Science.gov (United States)

Baad, Rajendra; Kapse, Sonam C; Rathod, Nanita; Sonawane, Kishor; Thete, Sanjay Gangadhar; Kumar, M Naveen

2013-06-01

Plasma cell dyscrasias (multiple myeloma, solitary plasmocytoma of bone and extra medullary plasmocytoma) are cha¬racterized by a monoclonal neoplastic proliferation of plasma cells of which Solitary plasmocytoma of bone (SPB) is a localized form. SPB is most frequently seen in vertebrae and secondarily in long bones. Its presence in jaws is extremely rare. The malignant plasma cells express monotypic cytoplasmic immunoglobulins and plasma cell-associated antigens, with an absence of immature B-cell antigens. Here we report a unique case of plasmacytoma in the right side of mandible, a chronology for diagnosis of the lesion is also reviewed along with clinical, radiographic, histopathological and immunohistochemical evidence. How to cite this article: Baad R, Kapse S C, Rathod N, Sonawane K, Thete S G, Naveen M K. Solitary Plasmacytoma of the Mandible - A Rare Entity. J Int Oral Health 2013; 5(3):97-101.

100 år i bevægelse

DEFF Research Database (Denmark)

Jacobsen, Kurt

Fysioterapi er i dag en anerkendt del af det danske sundhedsvæsen. Fysioterapeuter behandler årligt omkring 700.000 patienter på sygehuse, i kommuner og privat praksis, og har ph.d.-grader, er professorer og udfører forskning på højeste internationale niveau. Sådan har det ikke altid været...... havde fra begyndelsen en stærk standsfølelse, og i 100 år i bevægelse fortælles første gang historien om, hvorledes de satte en udvikling gang, der kom til at præge det danske sundhedsvæsen og vores forståelse af sundhed. I årtier kæmpede massøserne for anerkendelse som faggruppe, inden de i 1952 kunne...... kalde sig fysioterapeuter. De kæmpede med lægerne om kontrollen over faget, til de i 1968 fik statsautorisation. De kæmpede for en akademisk uddannelse, som de fik i 2002, og for retten til på egen hånd at stille diagnoser og behandle patienter, hvilket først blev en realitet så sent som i 2007. 100 år...

Lille spejl i hjernen dér

DEFF Research Database (Denmark)

Wallentin, Mikkel

2014-01-01

Myte? Spejlneuroner er blevet brugt til at forklare både læring, empati og sprog, og tidligere i år modtog Giacomo Rizzolatti den store Brain Prize for opdagelsen af dem. Ny bog er kritisk over for fænomenet.......Myte? Spejlneuroner er blevet brugt til at forklare både læring, empati og sprog, og tidligere i år modtog Giacomo Rizzolatti den store Brain Prize for opdagelsen af dem. Ny bog er kritisk over for fænomenet....

Evolution caused by extreme events.

Science.gov (United States)

Grant, Peter R; Grant, B Rosemary; Huey, Raymond B; Johnson, Marc T J; Knoll, Andrew H; Schmitt, Johanna

2017-06-19

Extreme events can be a major driver of evolutionary change over geological and contemporary timescales. Outstanding examples are evolutionary diversification following mass extinctions caused by extreme volcanism or asteroid impact. The evolution of organisms in contemporary time is typically viewed as a gradual and incremental process that results from genetic change, environmental perturbation or both. However, contemporary environments occasionally experience strong perturbations such as heat waves, floods, hurricanes, droughts and pest outbreaks. These extreme events set up strong selection pressures on organisms, and are small-scale analogues of the dramatic changes documented in the fossil record. Because extreme events are rare, almost by definition, they are difficult to study. So far most attention has been given to their ecological rather than to their evolutionary consequences. We review several case studies of contemporary evolution in response to two types of extreme environmental perturbations, episodic (pulse) or prolonged (press). Evolution is most likely to occur when extreme events alter community composition. We encourage investigators to be prepared for evolutionary change in response to rare events during long-term field studies.This article is part of the themed issue 'Behavioural, ecological and evolutionary responses to extreme climatic events'. © 2017 The Author(s).

Extreme heat and runoff extremes in the Swiss Alps

Directory of Open Access Journals (Sweden)

M. Zappa

2007-06-01

Full Text Available The hydrological response of Swiss river basins to the 2003 European summer heatwave was evaluated by a combined analysis of historical discharge records and specific applications of distributed hydrological modeling. In the summer of 2003, the discharge from headwater streams of the Swiss Central Plateau was only 40%–60% of the long-term average. For alpine basins runoff was about 60%–80% of the average. Glacierized basins showed the opposite behavior. According to the degree of glacierization, the average summer runoff was close or even above average. The hydrological model PREVAH was applied for the period 1982–2005. Even if the model was not calibrated for such extreme meteorological conditions, it was well able to simulate the hydrological responses of three basins. The aridity index φ describes feedbacks between hydrological and meteorological anomalies, and was adopted as an indicator of hydrological drought. The anomalies of φ and temperature in the summer of 2003 exceeded the 1982–2005 mean by more than 2 standard deviations. Catchments without glaciers showed negative correlations between φ and discharge <i>R>. In basins with about 15% glacierization, φ and <i>R> were not correlated. River basins with higher glacier percentages showed a positive correlation between φ and <i>R>. Icemelt was positively correlated with φ and reduced the variability of discharge with larger amounts of meltwater. Runoff generation from the non-glaciated sub-areas was limited by high evapotranspiration and reduced precipitation. The 2003 summer heatwave could be a precursor to similar events in the near future. Hydrological models and further data analysis will allow the identification of the most sensitive regions where heatwaves may become a recurrent natural hazard with large environmental, social and economical impacts.

Sintered cobalt-rare earth intermetallic product

International Nuclear Information System (INIS)

Benz, M.G.

1975-01-01

This patent describes a sintered product having substantially stable permanent magnet properties in air at room temperature. It comprises compacted particulate cobalt--rare earth alloy consisting essentially of a Co 5 R intermetallic phase and a CoR intermetallic phase which is richer in rare earth metal content than the Co 5 R phase, where R is a rare earth metal. The Co 5 R intermetallic phase is present in an amount of at least 65 percent by weight of the sintered product and the CoR intermetallic phase which is richer in rare earth metal content than the Co 5 R phase is present in a positive amount having a value ranging up to about 35 percent by weight of the product. The sintered product has a density of at least 87 percent and has pores which are substantially noninterconnecting and wherein the component grains have an average size less than 30 microns

Crystalline electric field at the rare-earth sites in RxY1-xCo5+y compounds (R= Dy and Tb)

International Nuclear Information System (INIS)

Han Xiufeng; Jin Hanmin; Chen Hong; Guo Guanghua; Zhao Tiesong

1992-01-01

The magnetic properties of R x Y 1-x Co 5+y compounds are reproduced well by a calculation based on the single-ion model. The values of the exchange field H cx and crystalline-electric-field parameters A m n at the rare-earth ion sites in R x Y 1-x Co 5+y (R = Dy and Tb) are evaluated by fitting the calculations to the experiments. The experiments include the temperature dependence of the spontaneous magnetization, the temperature dependence of the normalized magnetic moments of the rare-earth ions, the temperature dependence of the cone angle, the magnetization curves along the crystal axes at 4.2 K, and the hyperfine field at the Dy ion site

Nursery school at Vincennes: O.P.R.I. investigation

International Nuclear Information System (INIS)

Pasquier, J.L.; Fouquet, G.; Linden, G.

2001-01-01

After five children neoplasms at the nursery of Vincennes, the O.P.R.I. has realised two measurement campaigns during the year 2001. The track of a radioactive contamination, based on the private laboratory analysis has been denied by O.P.R.I. (N.C.)

Üst havayolları için mür tentürü, nane yağı ve mentol kombinasyonu içeren bir pastil

OpenAIRE

Öktemer, Tuğba; İpçi, Kağan; Bayar Muluk, Nuray; Cingi, Cemal

2016-01-01

Mür ve boraks içerek tentürler gargara solüsyonu olarak kullanılmaktadır. Mür sakızı, sindirim güçlüğü, ülserler, soğuk algınlığı, öksürük, astım, akciğer konjesyonu, artrit ağrısı ve kanser için de kullanılır. Mür, ağrıya tabi tutulan farelerde, ağrı kesici etkiler göstermiştir. Antiseptik olarak ağız ve boğaz inşamatuar lezyonlarında kullanılır. Boğaz ve ağzın iltihaplı lezyonlara uygulanır ve antispazmodik olarak kanser ve enfeksiyon hastalıklarının tedavisi için kullanılır. Bu yazıda mür ...

Utility of 16S rDNA Sequencing for Identification of Rare Pathogenic Bacteria.

Science.gov (United States)

Loong, Shih Keng; Khor, Chee Sieng; Jafar, Faizatul Lela; AbuBakar, Sazaly

2016-11-01

Phenotypic identification systems are established methods for laboratory identification of bacteria causing human infections. Here, the utility of phenotypic identification systems was compared against 16S rDNA identification method on clinical isolates obtained during a 5-year study period, with special emphasis on isolates that gave unsatisfactory identification. One hundred and eighty-seven clinical bacteria isolates were tested with commercial phenotypic identification systems and 16S rDNA sequencing. Isolate identities determined using phenotypic identification systems and 16S rDNA sequencing were compared for similarity at genus and species level, with 16S rDNA sequencing as the reference method. Phenotypic identification systems identified ~46% (86/187) of the isolates with identity similar to that identified using 16S rDNA sequencing. Approximately 39% (73/187) and ~15% (28/187) of the isolates showed different genus identity and could not be identified using the phenotypic identification systems, respectively. Both methods succeeded in determining the species identities of 55 isolates; however, only ~69% (38/55) of the isolates matched at species level. 16S rDNA sequencing could not determine the species of ~20% (37/187) of the isolates. The 16S rDNA sequencing is a useful method over the phenotypic identification systems for the identification of rare and difficult to identify bacteria species. The 16S rDNA sequencing method, however, does have limitation for species-level identification of some bacteria highlighting the need for better bacterial pathogen identification tools. © 2016 Wiley Periodicals, Inc.

25 år med selvbestemt abort i Norge

OpenAIRE

Vigran, Åsne; Lappegård, Trude

2003-01-01

Artiklene i Samfunnsspeilet er tilgjengelige fra SSBs nettsider: http://www.ssb.no/ssp/ Lov om selvbestemt abort ble vedtatt 30. mai 1978 og trådte i kraft året etter. Motstanderne av loven fryktet økte aborttall. 25 år etter at loven ble vedtatt, er aborttallene nedadgående. Dette gjelder spesielt blant tenåringsjenter, hvor dagens abortrate er 30 prosent lavere enn for 25 år siden.

Statistics of Extremes

KAUST Repository

Davison, Anthony C.; Huser, Raphaë l

2015-01-01

Statistics of extremes concerns inference for rare events. Often the events have never yet been observed, and their probabilities must therefore be estimated by extrapolation of tail models fitted to available data. Because data concerning the event

Etik och marknadsföring i bloggar : Var går gränsen för smygreklam?

OpenAIRE

Hellman, Anna

2014-01-01

Syftet med detta examensarbete är att belysa marknadsföringen i bloggar och dess etiska problem. Avsikten är att redogöra för var gränsen för smygreklam går och att få reda på hur mycket bloggarna känner till om ämnet. Bloggarnas andel av sociala medier samt mängden bloggläsare har vuxit explosionsartat. Marknadsföring och reklam i soci-ala medier har vuxit i och med populariteten av sociala medier bland folket. På grund av den ökade marknadsföringen i bloggar har smygreklam uppstått. Efterso...

Crystal-field splittings in rare-earth-based hard magnets: An ab initio approach

Science.gov (United States)

Delange, Pascal; Biermann, Silke; Miyake, Takashi; Pourovskii, Leonid

2017-10-01

We apply the first-principles density functional theory + dynamical mean-field theory framework to evaluate the crystal-field splitting on rare-earth sites in hard magnetic intermetallics. An atomic (Hubbard-I) approximation is employed for local correlations on the rare-earth 4 f shell and self-consistency in the charge density is implemented. We reduce the density functional theory self-interaction contribution to the crystal-field splitting by properly averaging the 4 f charge density before recalculating the one-electron Kohn-Sham potential. Our approach is shown to reproduce the experimental crystal-field splitting in the prototypical rare-earth hard magnet SmCo5. Applying it to R Fe12 and R Fe12X hard magnets (R =Nd , Sm and X =N , Li), we obtain in particular a large positive value of the crystal-field parameter A20〈r2〉 in NdFe12N resulting in a strong out-of-plane anisotropy observed experimentally. The sign of A20〈r2〉 is predicted to be reversed by substituting N with Li, leading to a strong out-of-plane anisotropy in SmFe12Li . We discuss the origin of this strong impact of N and Li interstitials on the crystal-field splitting on rare-earth sites.

The greenhouse effect and extreme weather

International Nuclear Information System (INIS)

Groenaas, Sigbjoern; Kvamstoe, Nils Gunnar

2002-01-01

The article asserts that an anthropogenic global warming is occurring. This greenhouse effect is expected to cause more occurrences of extreme weather. It is extremely difficult, however, to relate specific weather catastrophes to global warming with certainty, since such extreme weather conditions are rare historically. The subject is controversial. The article also discusses the public debate and the risk of floods

THE NOVEL OF THE JOURNALIST: ESRÂR-I CİNÂYÂT BİR GAZETECİNİN ROMANI: ESRÂR-I CİNÂYÂT

Directory of Open Access Journals (Sweden)

Ferhat KORKMAZ

2011-09-01

Full Text Available Modernism in Turkish literature begins by the mediation of journal. Most of new literary types attained to our literature owe their existances and developments to journal. Yusuf Kâmil Paşa brings in first translation novel to Turkish by means of consecutive narrative for a newspaper. After that novels are published by means of consecutive narrative in Tanzimat era. Ahmet Mithat Efendi is both journalist and novelist. Ahmet Mithat Efendi who seeks compromise between journal and novel handles the contribution of both type to each other in Esrâr-ı Cinâyât novel. In the novel, he discusses the cooperation of a civil servant who encounters pressure and a true journalist for the criminals to be catched and handed over to the justice and for the relief of the conscience of public. The novelist that makes journal and journalist the most important component for the solution of events gives a lot of information about the journalism in Tanzimat era, as well. On this occasion, the affairs like journalism, typography, Newsprinting Regulation (Matbuat Nizamnamesi, freedom of notion newspaper- government relation and censorship become the most important matters that emphasize on in the novel. Türk edebiyatında modernleşme gazete aracılığıyla başlar. Edebiyatımıza yeni kazandırılan pek çok tür varlığını ve gelişimini gazeteye borçludur. Yusuf Kâmil Paşa, gazetede tefrika ettirmek suretiyle ilk çeviri romanı Türkçeye kazandırır. Bundan sonra Tanzimat döneminde roman, gazetelerde tefrika yoluyla yayımlanır. Ahmet Mithat Efendi hem gazeteci hem de romancıdır. Gazete ve roman arasında uzlaşma arayan Ahmet Mithat Efendi, Esrâr-ı Cinâyât romanında bu iki türün birbirine olan katkısını ele alır. Romanda doğruların yanında yer alan bir gazeteci ve baskıyla karşı karşıya kalan bir devlet memurunun suçluların yakalanıp adalete teslim edilmesi ve kamuoyunun vicdanının rahatlatılması için yaptıkları işbirliği

Flood risk assessment in France: comparison of extreme flood estimation methods (EXTRAFLO project, Task 7)

Science.gov (United States)

Garavaglia, F.; Paquet, E.; Lang, M.; Renard, B.; Arnaud, P.; Aubert, Y.; Carre, J.

2013-12-01

of five watersheds located in the South of France. References : O. CAYLA : Probability calculation of design floods abd inflows - SPEED. Waterpower 1995, San Francisco, California 1995 CFGB : Design flood determination by the gradex method. Bulletin du Comité Français des Grands Barrages News 96, 18th congress CIGB-ICOLD n2, nov:108, 1994. F. GARAVAGLIA et al. : Introducing a rainfall compound distribution model based on weather patterns subsampling. Hydrology and Earth System Sciences, 14, 951-964, 2010. J. LAVABRE et al. : SHYREG : une méthode pour l'estimation régionale des débits de crue. application aux régions méditerranéennes françaises. Ingénierie EAT, 97-111, 2003. M. MARGOUM : Estimation des crues rares et extrêmes : le modèle AGREGEE. Conceptions et remières validations. PhD, Ecole des Mines de Paris, 1992. R. NAULET et al. : Flood frequency analysis on the Ardèche river using French documentary sources from the two last centuries. Journal of Hydrology, 313:58-78, 2005. E. PAQUET et al. : The SCHADEX method: A semi-continuous rainfall-runoff simulation for extreme flood estimation, Journal of Hydrology, 495, 23-37, 2013.

Papilliferous Keratoameloblastoma: An Extremely Rare Case Report

Directory of Open Access Journals (Sweden)

Neeta Mohanty

2013-01-01

Full Text Available Odontogenic tumors develop in the jaw bones from the odontogenic tissue-oral epithelium in tooth germ, enamel organ, dental papilla, reduced enamel epithelium, remnants of Hertwig’s root sheath or dental lamina, and so forth. Hence, a bewildering variety of tumors are encountered in the maxilla and mandible. Ameloblastoma is the second most common odontogenic neoplasm after odontomes, and it has numerous clinical and histologic variants. We report a very rare histologic variant: the papilliferous keratoameloblastoma which is the fifth reported case in the English literature.

Onychomycosis: A Rare Presentation of Fungal Urinary Tract Infection in an Extremely Preterm Neonate

Directory of Open Access Journals (Sweden)

Shilpa Kalane

2015-06-01

Full Text Available Onychomycosis refers to nail infections, caused by fungi including yeasts and non-dermatophyte moulds. One or several toenails or fingernails (seldom all may be involved in this condition. Many cases of fingernail onychomycosis are due to yeasts. Fungal infection has emerged as an important cause of neonatal infection, associated with significant morbidity and mortality, especially in very low birth weight (< 1500 g and extremely low birth weight (< 1000 g infants. Herein, we report a case of a 24-day-old male infant, who presented with onychomycosis on the left ring fingernail, associated with fungal urinary tract infection (UTI. The evaluation of nails helped us detect fungal UTI. To date, there have been no reports suggesting onychomycosis as a presentation of fungal UTI. We could not find the association between onychomycosis and neonatal fungal UTI. Hence, retrospectively, it can be said that onychomycosis was a presentation of fungal UTI. Further studies are required to evaluate the etiology and treatment of neonatal onychomycosis. Moreover, dermatologists should pay particular attention to this rare event.

A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus

Directory of Open Access Journals (Sweden)

Crumpacker Clyde S

2011-01-01

Full Text Available Abstract Background The major hurdle in the treatment of Human Immunodeficiency virus type 1 (HIV-1 includes the development of drug resistance-associated mutations in the target regions of the virus. Since reverse transcriptase (RT is essential for HIV-1 replication, several nucleoside analogues have been developed to target RT of the virus. Clinical studies have shown that mutations at RT codon 65 and 74 which are located in β3-β4 linkage group of finger sub-domain of RT are selected during treatment with several RT inhibitors, including didanosine, deoxycytidine, abacavir and tenofovir. Interestingly, the co-selection of K65R and L74V is rare in clinical settings. We have previously shown that K65R and L74V are incompatible and a R→K reversion occurs at codon 65 during replication of the virus. Analysis of the HIV resistance database has revealed that similar to K65R+L74V, the double mutant K65R+L74I is also rare. We sought to compare the impact of L→V versus L→I change at codon 74 in the background of K65R mutation, on the replication of doubly mutant viruses. Methods Proviral clones containing K65R, L74V, L74I, K65R+L74V and K65R+L74I RT mutations were created in pNL4-3 backbone and viruses were produced in 293T cells. Replication efficiencies of all the viruses were compared in peripheral blood mononuclear (PBM cells in the absence of selection pressure. Replication capacity (RC of mutant viruses in relation to wild type was calculated on the basis of antigen p24 production and RT activity, and paired analysis by student t-test was performed among RCs of doubly mutant viruses. Reversion at RT codons 65 and 74 was monitored during replication in PBM cells. In vitro processivity of mutant RTs was measured to analyze the impact of amino acid changes at RT codon 74. Results Replication kinetics plot showed that all of the mutant viruses were attenuated as compared to wild type (WT virus. Although attenuated in comparison to WT virus

A rare complication of tuberculosis: Acute paraplegia | Aydın ...

African Journals Online (AJOL)

A rare complication of tuberculosis: Acute paraplegia. Teoman Aydın, Özgür Taşpınar, Yasar Keskin, Müge Kepekçi, Meryem Güneşer, Adil Çamlı, Hakan Seyithanoğlu, Huriye Kızıltan, Ali Hikmet Eriş ...

Present status of two R.F. heating schemes: I.C.R.H. and L.H.R.H

International Nuclear Information System (INIS)

Consoli, T.

1977-01-01

Among the large number of wave-plasma interaction, Ion-Cyclotron Resonant Heating (I.C.R.H.) and Lower Hybrid Resonant Heating (L.H.R.H.), are two promising additional R.F. heating schemes for toroidal hot plasma. They both offer the advantage of using power generators which requires a moderate development for next generation machines. It seems important to try to state in the limits of this paper the present experimental situation of these two R.F. heating methods as it results from the vast literature published from the last European Conference

R.I.S.-125 {sup 125}I air monitor system

Energy Technology Data Exchange (ETDEWEB)

Belaish, I; Levinson, S; German, U; Pelled, O; Laichter, Y; Wangrovitz, U; Tirosh, D; Barak, D [Israel Atomic Energy Commission, Beersheba (Israel). Nuclear Research Center-Negev

1996-12-01

We have developed at NRCN a prototype of a continuous K-Ray air monitoring (CAM) system called `R.1.S.-125` (Radioactive Isotope Sampler for {sup 125}I). The system. was checked according to ANSI N42.17B -1989 (authors).

Magnetic nanosized rare earth iron garnets R_3Fe_5O_1_2: Sol–gel fabrication, characterization and reinspection

International Nuclear Information System (INIS)

Opuchovic, Olga; Kareiva, Aivaras; Mazeika, Kestutis; Baltrunas, Dalis

2017-01-01

The magnetic nanosized rare earth iron garnets (R_3Fe_5O_1_2, where R=Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu) were prepared by an aqueous sol–gel method. Herein we present, that all these garnets can be obtained by this effective synthesis method simply by changing the temperature of the final annealing. It was also demonstrated, that a different annealing temperature leads to a different particle size distribution of the final product. The SEM analysis results revealed that the smallest particles were formed in the range of 75–130 nm. The phase purity and structure of the rare earth iron garnets were estimated using XRD analysis and Mössbauer spectroscopy. Magnetic properties were determined by magnetization measurements. The relation between the particle size, composition and magnetic properties of the sol-gel derived garnets were also discussed in this study. - Highlights: • First time series of R_3Fe_5O_1_2 (R=from Sm to Lu) are prepared by sol–gel process. • Different sintering temperature leads to the different particle size distribution. • Correlation between microstructure, composition and magnetic properties is shown.

Når mobilen tager magten - nærvær i den digitale tidsalter

DEFF Research Database (Denmark)

Fenger, Morten Munthe

at se ind i en skærm? "Når mobilen tager magten" beskriver, hvordan den digitale teknologi og sociale medier såsom Facebook, Instagram og Snapchat går direkte ind og udnytter menneskets instikter, og tilfredsstiller vores behov hurtigere end vores forstand og vilje kan følge med og sige fra. "Når...

Non-syndromic hearing loss caused by the dominant cis mutation R75Q with the recessive mutation V37I of the GJB2 (Connexin 26) gene.

Science.gov (United States)

Kim, Juwon; Jung, Jinsei; Lee, Min Goo; Choi, Jae Young; Lee, Kyung-A

2015-06-19

GJB2 alleles containing two cis mutations have been rarely found in non-syndromic hearing loss. Herein, we present a Korean patient with non-syndromic hearing loss caused by the R75Q cis mutation with V37I, which arose de novo in the father and was inherited by the patient. Biochemical coupling and hemichannel permeability assays were performed after molecular cloning and transfection of HEK293T cells. Student's t-tests or analysis of variance followed by Tukey's multiple comparison test was used as statistical analysis. Biochemical coupling was significantly reduced in connexin 26 (Cx26)-R75Q- and Cx26-V37I-transfected cells, with greater extent in Cx26-R75Q and Cx26-R75Q+V37I cells. Interestingly, our patient and his father with the mutations had more residual hearing compared with patients with the dominant mutation alone. Although the difference in hemichannel activity between R75Q alone and R75Q in combination with V37I failed to reach significance, it is of note that there is a possibility that V37I located upstream of R75Q might have the ability to ameliorate R75Q expression. Our study emphasizes the importance of cis mutations with R75Q, as the gene effect of R75Q can be modulated depending on the type of additional mutation.

Specific heat of rare earth cobaltates RCoO{sub 3} (R = La, Pr and Nd)

Energy Technology Data Exchange (ETDEWEB)

Thakur, Rasna, E-mail: rasnathakur@yahoo.com [Department of Physics, Barkatullah University, Bhopal 462026 (India); Srivastava, Archana [Department of Physics, Sri Sathya Sai College for Women, Bhopal 462024 (India); Thakur, Rajesh K.; Gaur, N.K. [Department of Physics, Barkatullah University, Bhopal 462026 (India)

2012-03-05

Highlights: Black-Right-Pointing-Pointer We have reported the temperature dependence (5 K {<=} T {<=} 1000 K) of the lattice contribution to the specific heat of rhombohedral LaCoO{sub 3} and orthocobaltates RCoO{sub 3} (R = Pr and Nd). Black-Right-Pointing-Pointer The strong electron phonon interactions are present in these compounds and lattice distortions can affect them substantially. Black-Right-Pointing-Pointer Thus Rigid Ion Model (RIM) is used for the first time to study the cohesive and thermal properties of the cobaltates RCoO{sub 3} with rare earth cation (R = La, Pr and Nd). Black-Right-Pointing-Pointer The values of specific heat calculated by us have shown remarkably good agreement with corresponding experimental data. Black-Right-Pointing-Pointer In addition, the results on the temperature dependence of cohesive energy ({phi}), molecular force constant (f), Reststrahlen frequency ({upsilon}), Debye temperature ({theta}{sub D}) and Gruneisen parameter ({gamma}) are also reported. - Abstract: We have reported the temperature dependence (5 K {<=} T {<=} 1000 K) of the lattice contribution to the specific heat of rhombohedral LaCoO{sub 3} and orthocobaltates RCoO{sub 3} (R = Pr and Nd). The strong electron phonon interactions are present in these compounds and lattice distortions can affect them substantially. Thus Rigid Ion Model (RIM) is used for the first time to study the cohesive and thermal properties of the cobaltates RCoO{sub 3} with rare earth cation (R = La, Pr and Nd). The values of specific heat calculated by us have shown remarkably good agreement with corresponding experimental data. In addition, the results on the temperature dependence of cohesive energy ({phi}), molecular force constant (f), Reststrahlen frequency ({upsilon}), Debye temperature ({theta}{sub D}) and Gruneisen parameter ({gamma}) are also reported.

Militær ledelse i et professionsperspektiv

DEFF Research Database (Denmark)

Nørgaard, Katrine; Holsting, Vilhelm Stefan

Begrebet ”militær ledelse” anvendes både bredt om alle de ledelsesformer, der udøves i en militær kontekst og mere snævert som den specifikke ledelsesform, der knytter sig til militære operationer. Det efterlader imidlertid spørgsmålet om, hvorved militær ledelse adskiller sig fra andre former fo...... etik, dvs. en bestemt professionsdannelse, som ikke kan erhverves udenfor det militære praksisfællesskab, men som opbygges gennem en løbende teoretisk og praktisk disciplinering....

BIM som Informationsbärare in i Förvaltningen : En studie vid Forsmarks Kraftgrupp

OpenAIRE

Svens, Therése

2013-01-01

BIM, Building Information Modeling, börjar vinna mark inom byggbranschen i Sverige och är en vedertagen process i vart och vartannat byggprojekt. Forsmarks Kraftgrupp står inför både upprustningar av sina anläggningar och nyproduktion av bland annat kontor, verkstad och hotell. BIM framstår nu som en lukrativ metod för att dra ner på projektkostnaderna, men även för att få ytterligare ordning och struktur på den enorma mängd dokumentation som ackumulerat under de dryga trettio åren av drift. ...

Unusual pressure dependence of the crystallographic structure in RNiO{sub 3} perovskites (R = rare earth)

Energy Technology Data Exchange (ETDEWEB)

Medarde, M.; Mesot, J.; Rosenkranz, S. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Lacorre, P. [Lab. Fluorures, Le Mans (France); Marshall, W.; Loveday, J.S. [Edinburgh Univ. (United Kingdom); Klotz, S.; Hamel, G. [Paris-6 Univ., 75 (France)

1997-09-01

We report the first experimental observation of a pressure-induced structural phase transition in the RNiO{sub 3} series (R = rare earth). At {approx_equal} 40 kbar, the space group of NdNiO{sub 3} changes from Pbnm(orthorhombic) to the PrNiO{sub 3} indicating that the symmetry of the structure increases with pressure. (author) 1 fig., 7 refs.

Satsa på förskolan! : En studie om förskollärares upplevda arbetstillfredsställelse

OpenAIRE

Tornow, Janine

2013-01-01

Syftet med den här studien var att undersöka förskollärares upplevda arbetstillfredsställelse. Med avseende på den upplevda arbetstillfredsställelsen undersöktes skillnader mellan kommunala och fristående förskolor. Studiens teoretiska utgångspunkt är tagen ur Maccoby’s motivationsmodell. Undersökningen genomfördes på 17 olika förskolor i en svensk kommun med hjälp av en webbaserad enkät. Enkäten riktade sig till utbildade förskollärare på nio kommunala respektive åtta fristående förskolor. I...

The calculation of rare-earth levels in layered cobaltates R.sub.x/3./sub.CoO.sub.2./sub. (x≤1)

Czech Academy of Sciences Publication Activity Database

Novák, Pavel; Knížek, Karel; Jirák, Zdeněk; Buršík, Josef

2015-01-01

Roč. 381, May (2015), s. 145-150 ISSN 0304-8853 R&D Projects: GA ČR GA13-03708S Institutional support: RVO:68378271 ; RVO:61388980 Keywords : rare- earth electronic levels * crystal field splitting * layered cobaltates Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.357, year: 2015

An Erupted Dilated Odontoma: A Rare Presentation

Directory of Open Access Journals (Sweden)

Gaurav Sharma

2016-01-01

Full Text Available A dilated odontoma is an extremely rare developmental anomaly represented as a dilatation of the crown and root as a consequence of a deep, enamel-lined invagination and is considered a severe variant of dens invaginatus. An oval shape of the tooth lacking morphological characteristics of a crown or root implies that the invagination happened in the initial stages of morphodifferentiation. Spontaneous eruption of an odontoma is a rare occurrence and the occurrence of a dilated odontoma in a supernumerary tooth is even rarer with only a few case reports documented in the English literature. We present an extremely rare case of erupted dilated odontoma occurring in the supernumerary tooth in anterior maxillary region in an 18-year-old male, which, to the best of our knowledge, is the first ever case reported in English literature.

Polymer Derived Rare Earth Silicate Nanocomposite Protective Coatings for Nuclear Thermal Propulsion Systems, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The objective of this Phase I SBIR program is to develop polymer derived rare earth silicate nanocomposite environmental barrier coatings (EBC) for providing...

Vilkår og muligheder i det sociale web

DEFF Research Database (Denmark)

2009-01-01

Dette podcast gengiver et indlæg på Forskningsnetkonferencen 2007 om muligheder og vilkår i det sociale web med særligt henblik på e-læring. Fysisk medie: Flash-fil......Dette podcast gengiver et indlæg på Forskningsnetkonferencen 2007 om muligheder og vilkår i det sociale web med særligt henblik på e-læring. Fysisk medie: Flash-fil...

Hiccup: An Extremely Rare Presentation of Thyrotoxicosis of Graves’ Disease

Directory of Open Access Journals (Sweden)

Irshad Parray

2011-03-01

Full Text Available Persistent hiccup is a rare but potentially severe condition that can be symptomatic of a variety of diseases or idiopathic. Most episodes last only a few minutes and are self-limited, but hiccup can get persistent and become a real problem for physician and patient alike. The center of hiccup may be activated by a great variety of stimuli travelling along different nerve pathways and bring different effecter responses. We report a case of persistent hiccup as a presentation of impending thyroid storm of Graves’ disease. Though the condition is rare, clinicians should remain alert to the possibility of this diagnosis.

Rare Events

Science.gov (United States)

2009-10-01

Limited Operational Exercise 1. 1A Limited Operational Exercise is a multiplayer experiment designed to exploit and study information sharing and...1.4 Summary of the Study The “rare event” of interest is an extreme, deliberate act of violence , destruction or socioeconomic disruption, such as an...connection with terrorism inves- tigations. The programs then use some combination of doctrinal revision and rewards to induce the people to abandon violence

Pheochromocytoma as a rare cause of hypertension in a 46 X, i(X)(q10) turner syndrome: a case report and literature review.

Science.gov (United States)

Shin, Ji Yeon; Kim, Bo Hyun; Kim, Young Keum; Kim, Tae Hwa; Kim, Eun Heui; Lee, Min Jin; Kim, Jong Ho; Jeon, Yun Kyung; Kim, Sang Soo; Kim, In Joo

2018-05-10

Cardiovascular disease (CVD) presents the most serious health problems and contributes to the increased mortality in young women with Turner syndrome. Arterial hypertension in Turner syndrome patients is significantly more prevalent than that in a general age-matched control group. The aetiology of hypertension in Turner syndrome varies, even in the absence of cardiac anomalies and obvious structural renal abnormalities. Pheochromocytoma is an extremely rare cause among various etiologies for hypertension in patients with Turner syndrome. Here, we reported a pheochromocytoma as a rare cause of hypertension in Turner syndrome patient. A 21-year-old woman who has diagnosed with Turner syndrome with a karyotype of 46,X,i(X)(q10) visited for hypertension and mild headache. Transthoracic echography (TTE) showed no definite persistent ductus arteriosus shunt flow and cardiac valve abnormalities. Considering other important secondary causes like pheochromocytoma, hormonal studies were performed and the results showed increased serum norepinephrine, serum normetanephrine, and 24 h urine norepinephrine. We performed an abdominal computed tomography (CT) to confirm the location of pheochromocytoma. Abdominal CT showed a 1.9 cm right adrenal mass. I-131 meta-iodobenzylguanidine (MIBG) scintigraphy showed a right adrenal uptake. Laparoscopic adrenalectomy was performed and confirmed a pheochromocytoma. After surgery, blood pressure was within normal ranges and postoperative course was uneventful, and no recurrence developed via biochemical tests and abdominal CT until 24 months. Our case and previous literatures suggest that hypertension caused by pheochromocytoma which is a rare but important and potentially lethal cause of hypertension in Turner syndrome. This case underlines the importance of early detection of pheochromocytoma in Turner syndrome. Clinicians should keep in mind that pheochromocytoma can be a cause of hypertension in patients with Turner syndrome.

Statistics of Extremes

KAUST Repository

Davison, Anthony C.

2015-04-10

Statistics of extremes concerns inference for rare events. Often the events have never yet been observed, and their probabilities must therefore be estimated by extrapolation of tail models fitted to available data. Because data concerning the event of interest may be very limited, efficient methods of inference play an important role. This article reviews this domain, emphasizing current research topics. We first sketch the classical theory of extremes for maxima and threshold exceedances of stationary series. We then review multivariate theory, distinguishing asymptotic independence and dependence models, followed by a description of models for spatial and spatiotemporal extreme events. Finally, we discuss inference and describe two applications. Animations illustrate some of the main ideas. © 2015 by Annual Reviews. All rights reserved.

Discovery of Rare and Highly Toxic Microcystins from Lichen-Associated Cyanobacterium Nostoc sp. Strain IO-102-I

Science.gov (United States)

Oksanen, Ilona; Jokela, Jouni; Fewer, David P.; Wahlsten, Matti; Rikkinen, Jouko; Sivonen, Kaarina

2004-01-01

The production of hepatotoxic cyclic heptapeptides, microcystins, is almost exclusively reported from planktonic cyanobacteria. Here we show that a terrestrial cyanobacterium Nostoc sp. strain IO-102-I isolated from a lichen association produces six different microcystins. Microcystins were identified with liquid chromatography-UV mass spectrometry by their retention times, UV spectra, mass fragmentation, and comparison to microcystins from the aquatic Nostoc sp. strain 152. The dominant microcystin produced by Nostoc sp. strain IO-102-I was the highly toxic [ADMAdda5]microcystin-LR, which accounted for ca. 80% of the total microcystins. We assigned a structure of [DMAdda5]microcystin-LR and [d-Asp3,ADMAdda5]microcystin-LR and a partial structure of three new [ADMAdda5]-XR type of microcystin variants. Interestingly, Nostoc spp. strains IO-102-I and 152 synthesized only the rare ADMAdda and DMAdda subfamilies of microcystin variants. Phylogenetic analyses demonstrated congruence between genes involved directly in microcystin biosynthesis and the 16S rRNA and rpoC1 genes of Nostoc sp. strain IO-102-I. Nostoc sp. strain 152 and the Nostoc sp. strain IO-102-I are distantly related, revealing a sporadic distribution of toxin production in the genus Nostoc. Nostoc sp. strain IO-102-I is closely related to Nostoc punctiforme PCC 73102 and other symbiotic Nostoc strains and most likely belongs to this species. Together, this suggests that other terrestrial and aquatic strains of the genus Nostoc may have retained the genes necessary for microcystin biosynthesis. PMID:15466511

Interrupted reperfusion reduces the activation of NADPH oxidase after cerebral I/R injury.

Science.gov (United States)

Shen, Jia; Bai, Xiao-Yin; Qin, Yuan; Jin, Wei-Wei; Zhou, Jing-Yin; Zhou, Ji-Ping; Yan, Ying-Gang; Wang, Qiong; Bruce, Iain C; Chen, Jiang-Hua; Xia, Qiang

2011-06-15

Interrupted reperfusion reduces ischemia/reperfusion (I/R) injury. This study was designed to determine whether NADPH oxidase participates in the neural protection against global I/R injury after interrupted reperfusion. Mice were randomly divided into five groups: sham (sham-operated), I/R (20-min global I/R), RR (I/R+interrupted reperfusion), Apo (I/R+apocynin administration), and RR+Apo. Behavioral tests (pole test, beam walking, and Morris water maze) and Nissl staining were undertaken in all five groups; superoxide levels, expression of gp91(phox) and p47(phox), p47(phox) translocation, and Rac1 activation were measured in the sham, I/R, and RR groups. The motor coordination, bradykinesia, and spatial learning and memory, as well as the neuron survival rates, were better in the RR, Apo, and RR+Apo groups than in the I/R group. The NADPH oxidase-dependent superoxide levels, p47(phox) and gp91(phox) expression, p47(phox) translocation, and Rac1 activation were lower in the RR group than in the I/R group. In conclusion, the neural protective effect of interrupted reperfusion is at least partly mediated by decreasing the expression and assembly of NADPH oxidase and the levels of NADPH oxidase-derived superoxide. The most striking reduction Rac1-GTP in the RR group suggests that interrupted reperfusion also acts on the activation of assembled NADPH oxidase by reducing the availability of Rac1-GTP. Copyright © 2011 Elsevier Inc. All rights reserved.

Rare gases in Samoan xenoliths

Science.gov (United States)

Poreda, R. J.; Farley, K. A.

1992-09-01

The rare gas isotopic compositions of residual harzburgite xenoliths from Savai'i (SAV locality) and an unnamed seamount south of the Samoan chain (PPT locality) provide important constraints on the rare gas evolution of the mantle and atmosphere. Despite heterogeneous trace element compositions, the rare gas characteristics of the xenoliths from each of the two localities are strikingly similar. SAV and PPT xenoliths have 3He/ 4He ratios of11.1 ± 0.5 R A and21.6 ± 1 R A, respectively; this range is comparable to the 3He/ 4He ratios in Samoan lavas and clearly demonstrates that they have trapped gases from a relatively undegassed reservoir. The neon results are not consistent with mixing between MORB and a plume source with an atmospheric signature. Rather, the neon isotopes reflect either a variably degassed mantle (with a relative order of degassing of Loihi Honda et al. that the 20Ne/ 22Ne ratio in the mantle more closely resembles the solar ratio than the atmospheric one. 40Ar/ 36Ar ratios in the least contaminated samples range from 4,000 to 12,000 with the highest values in the 22 RA PPT xenoliths. There is no evidence for atmospheric 40Ar/ 36Ar ratios in the mantle source of these samples, which indicates that the lower mantle may have 40Ar/ 36Ar ratios in excess of 5,000. Xenon isotopic anomalies in 129Xe and 136Xe are as high as 6%, or about half of the maximum MORB excess and are consistent with the less degassed nature of the Samoan mantle source. These results contradict previous suggestions that the high 3He/ 4He mantle has a near-atmospheric heavy rare gas isotopic composition.

Polygenic determinants in extremes of high-density lipoprotein cholesterol.

Science.gov (United States)

Dron, Jacqueline S; Wang, Jian; Low-Kam, Cécile; Khetarpal, Sumeet A; Robinson, John F; McIntyre, Adam D; Ban, Matthew R; Cao, Henian; Rhainds, David; Dubé, Marie-Pierre; Rader, Daniel J; Lettre, Guillaume; Tardif, Jean-Claude; Hegele, Robert A

2017-11-01

HDL cholesterol (HDL-C) remains a superior biochemical predictor of CVD risk, but its genetic basis is incompletely defined. In patients with extreme HDL-C concentrations, we concurrently evaluated the contributions of multiple large- and small-effect genetic variants. In a discovery cohort of 255 unrelated lipid clinic patients with extreme HDL-C levels, we used a targeted next-generation sequencing panel to evaluate rare variants in known HDL metabolism genes, simultaneously with common variants bundled into a polygenic trait score. Two additional cohorts were used for validation and included 1,746 individuals from the Montréal Heart Institute Biobank and 1,048 individuals from the University of Pennsylvania. Findings were consistent between cohorts: we found rare heterozygous large-effect variants in 18.7% and 10.9% of low- and high-HDL-C patients, respectively. We also found common variant accumulation, indicated by extreme polygenic trait scores, in an additional 12.8% and 19.3% of overall cases of low- and high-HDL-C extremes, respectively. Thus, the genetic basis of extreme HDL-C concentrations encountered clinically is frequently polygenic, with contributions from both rare large-effect and common small-effect variants. Multiple types of genetic variants should be considered as contributing factors in patients with extreme dyslipidemia. Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

Reverse (posterior) cloaca with congenital rectal stenosis and pseudohermaphrodism: a rare entity with rare association

Science.gov (United States)

Ahmed, Intezar; Kureel, Shiv Narain; Chandra, Naveen

2010-01-01

Reverse (posterior) cloaca is itself a rare entity and association of this defect with other congenital syndromes or defects is extremely rare to find. To diagnose this unique anomaly one should be aware about this very infrequently encountered clinical entity. Reverse cloaca is a very rare variant of anorectal malformation in which urethra and vagina fused to form a urogenital sinus that diverts posteriorly and opens in the anterior rectal wall at the anus or immediately anterior to it. We report a neonate with the rare clinical entity of reverse cloaca type C, pseudophallus with rudimentary urethra as a component of female pseudohermaphrodism and congenital rectal stenosis. Surprisingly, there was no associated urological abnormality on ultrasonography and laparotomy. PMID:22797480

Energy Transfer between Post-Transition Elements & Rare Earths in Oxide & Chalcogenide Glasses.

Science.gov (United States)

1979-08-27

Caird [13]. A calculation of reduced matrix elements of Pr3 in 20 Na O • 80 TeO2 glass [14] showed that they differ slightly from data of ref. [121... glasses Transition (lass 35 ZnO 65 TeO2 20 Na2 O 80 TeO 2 fX 106 fX 106 l.,eas 3a, a) Ia’l. faI f.me.s f al f+ I fal 3 H4 - 3 H6 1.56 1.65 1.12...Rare-Earth Doped Glasses 20. jIST HAEV CCnFn~m ,i cn,on ra e sideit If c."*Ar’ -- ~ 14-r by t?-h.c .: r Intensity parameters, radiative transition

Enzymatic characteristics of a recombinant neutral protease I (rNpI) from Aspergillus oryzae expressed in Pichia pastoris.

Science.gov (United States)

Ke, Ye; Huang, Wei-Qian; Li, Jia-zhou; Xie, Ming-quan; Luo, Xiao-chun

2012-12-12

A truncated neutral protease I (NpI) from Aspergillus oryzae 3.042 was expressed in Pichia pastoris with a high enzyme yield of 43101 U/mL. Its optimum pH was about 8.0, and it was stable in the pH range of 5.0-9.0. Its optimum temperature was about 55 °C and retained >90% activity at 50 °C for 120 min. Recombinant NpI (rNpI) was inhibited by Cu(2+) and EDTA. Eight cleavage sites of rNpI in oxidized insulin B-chain were determined by mass spectrometry, and five of them had high hydrophobic amino acid affinity, which makes it efficient in producing antihypertensive peptide IPP from β-casein and a potential debittering agent. The high degree of hydrolysis (DH) of rNpI to soybean protein (8.8%) and peanut protein (11.1%) compared to papain and alcalase makes it a good candidate in the processing of oil industry byproducts. The mutagenesis of H(429), H(433), and E(453) in the deduced zinc-binding motif confirmed rNpI as a gluzincin. All of these results show the great potential of rNpI to be used in the protein hydrolysis industry.

Angiomyolipoma and Malignant PEComa: Discussion of Two Rare Adrenal Tumors

Directory of Open Access Journals (Sweden)

Douglas Kwazneski II

2016-01-01

Full Text Available Angiomyolipoma and PEComa are rare tumors descending from perivascular epithelial cells (PECs, with distinctive IHC, morphological, and ultrastructural features. The kidney is the most frequent site of origin, but not the only one; however, adrenal gland angiomyolipomas are extremely rare. We describe two cases being found in the adrenal glands. Given the paucity of literature on the subject, more information on this disease is necessary for diagnosis and treatment. Here, we describe two complete case reports, from presentation to treatment and follow-up, along with imaging and microscopic pathology samples, and provide a comprehensive review as to the history and current literature available regarding these extremely rare tumors.

Polygenic determinants in extremes of high-density lipoprotein cholesterol[S

Science.gov (United States)

Dron, Jacqueline S.; Wang, Jian; Low-Kam, Cécile; Khetarpal, Sumeet A.; Robinson, John F.; McIntyre, Adam D.; Ban, Matthew R.; Cao, Henian; Rhainds, David; Dubé, Marie-Pierre; Rader, Daniel J.; Lettre, Guillaume; Tardif, Jean-Claude

2017-01-01

HDL cholesterol (HDL-C) remains a superior biochemical predictor of CVD risk, but its genetic basis is incompletely defined. In patients with extreme HDL-C concentrations, we concurrently evaluated the contributions of multiple large- and small-effect genetic variants. In a discovery cohort of 255 unrelated lipid clinic patients with extreme HDL-C levels, we used a targeted next-generation sequencing panel to evaluate rare variants in known HDL metabolism genes, simultaneously with common variants bundled into a polygenic trait score. Two additional cohorts were used for validation and included 1,746 individuals from the Montréal Heart Institute Biobank and 1,048 individuals from the University of Pennsylvania. Findings were consistent between cohorts: we found rare heterozygous large-effect variants in 18.7% and 10.9% of low- and high-HDL-C patients, respectively. We also found common variant accumulation, indicated by extreme polygenic trait scores, in an additional 12.8% and 19.3% of overall cases of low- and high-HDL-C extremes, respectively. Thus, the genetic basis of extreme HDL-C concentrations encountered clinically is frequently polygenic, with contributions from both rare large-effect and common small-effect variants. Multiple types of genetic variants should be considered as contributing factors in patients with extreme dyslipidemia. PMID:28870971

The H IX galaxy survey - II. H I kinematics of H I eXtreme galaxies

Science.gov (United States)

Lutz, K. A.; Kilborn, V. A.; Koribalski, B. S.; Catinella, B.; Józsa, G. I. G.; Wong, O. I.; Stevens, A. R. H.; Obreschkow, D.; Dénes, H.

2018-05-01

By analysing a sample of galaxies selected from the H I Parkes All Sky Survey (HIPASS) to contain more than 2.5 times their expected H I content based on their optical properties, we investigate what drives these H I eXtreme (H IX) galaxies to be so H I-rich. We model the H I kinematics with the Tilted Ring Fitting Code TiRiFiC and compare the observed H IX galaxies to a control sample of galaxies from HIPASS as well as simulated galaxies built with the semi-analytic model DARK SAGE. We find that (1) H I discs in H IX galaxies are more likely to be warped and more likely to host H I arms and tails than in the control galaxies, (2) the average H I and average stellar column density of H IX galaxies is comparable to the control sample, (3) H IX galaxies have higher H I and baryonic specific angular momenta than control galaxies, (4) most H IX galaxies live in higher spin haloes than most control galaxies. These results suggest that H IX galaxies are H I-rich because they can support more H I against gravitational instability due to their high specific angular momentum. The majority of the H IX galaxies inherits their high specific angular momentum from their halo. The H I content of H IX galaxies might be further increased by gas-rich minor mergers. This paper is based on data obtained with the Australia Telescope Compact Array through the large program C 2705.

The C.E.F.R.I

International Nuclear Information System (INIS)

Canipelle, A.D.

1999-01-01

The C.E.F.R.I. (French Committee of Enterprises certification for the training and Follow up of personnel working under Ionizing Radiations) has for aim to create a frame of mind, a culture of prevention and optimization in the field of radiation protection by the brought into operation in intervening enterprises and training organisms. (N.C.)

Glomus tumor of penis- A rare case

Directory of Open Access Journals (Sweden)

Madhuri S. Kate

2013-01-01

Full Text Available Glomus tumors are rare, painful, and benign soft tissue tumors of the skin arising from the glomus body, an arteriovenous thermoregulatory structure. This lesion is usually found on the extremities. Glomus tumor involving the external genital organs including penis is extremely rare. Until now, only few cases have been reported in the available literature. A 22 year old male patient presented with a painful nodule over the penis. The pathologic diagnosis was glomus tumor of the glans penis. We report herewith a case of glomus tumor of penis diagnosed on histopathologic examination. Glomus tumor, being a benign neoplasm, complete extirpation of the glomus tumor is the treatment of choice.

The role of land-climate interactions for the regional amplification of temperature extremes in climate projections

Science.gov (United States)

Seneviratne, S. I.; Vogel, M.; Zscheischler, J.; Schwingshackl, C.; Davin, E.; Gudmundsson, L.; Guillod, B.; Hauser, M.; Hirsch, A.; Hirschi, M.; Humphrey, V.; Thiery, W.

2017-12-01

Regional hot extremes are projected to increase more strongly than the global mean temperature, with substantially larger changes than 2°C even if global warming is limited to this level (Seneviratne et al. 2016). This presentation will highlight the processes underlying this behavior, which is strongly related to land-climate feedbacks (Vogel et al. 2017). The identified feedbacks are also affecting the occurrence probability of compound drought and heat events (Zscheischler and Seneviratne 2017), with high relevance for impacts on forest fire and agriculture production. Moreover, the responsible land processes strongly contribute to the inter-model spread in the projections, and can thus be used to derive observations-based constraints to reduce the uncertainty of projected changes in climate extremes. Finally, we will also discuss the role of soil moisture effects on carbon uptake and their relevance for projections, as well as the role of land use changes in affecting the identified feedbacks and projected changes in climate extremes. References: Seneviratne, S.I., M. Donat, A.J. Pitman, R. Knutti, and R.L. Wilby, 2016: Allowable CO2 emissions based on regional and impact-related climate targets. Nature, 529, 477-483, doi:10.1038/nature16542. Vogel, M.M., R. Orth, F. Cheruy, S. Hagemann, R. Lorenz, B.J.J.M. Hurk, and S.I. Seneviratne, 2017: Regional amplification of projected changes in extreme temperatures strongly controlled by soil moisture-temperature feedbacks. Geophysical Research Letters, 44(3), 1511-1519, doi:10.1002/2016GL071235. Zscheischler, J., and S.I. Seneviratne, 2017: Dependence of drivers affects risks associated with compound events. Science Advances, 3(6), doi: 10.1126/sciadv.1700263

The R.I.R.S. scoring system: An innovative scoring system for predicting stone-free rate following retrograde intrarenal surgery.

Science.gov (United States)

Xiao, Yinglong; Li, Deng; Chen, Lei; Xu, Yaoting; Zhang, Dingguo; Shao, Yi; Lu, Jun

2017-11-21

To establish and internally validate an innovative R.I.R.S. scoring system that allows urologists to preoperatively estimate the stone-free rate (SFR) after retrograde intrarenal surgery (RIRS). This study included 382 eligible samples from a total 573 patients who underwent RIRS from January 2014 to December 2016. Four reproducible factors in the R.I.R.S. scoring system, including renal stone density, inferior pole stone, renal infundibular length and stone burden, were measured based on preoperative computed tomography of urography to evaluate the possibility of stone clearance after RIRS. The median cumulative diameter of the stones was 14 mm, and the interquartile range was 10 to 21. The SFR on postoperative day 1 in the present cohort was 61.5% (235 of 382), and the final SFR after 1 month was 73.6% (281 of 382). We established an innovative scoring system to evaluate SFR after RIRS using four preoperative characteristics. The range of the R.I.R.S. scoring system was 4 to 10. The overall score showed a great significance of stone-free status (p R.I.R.S. scoring system was 0.904. The R.I.R.S. scoring system is associated with SFR after RIRS. This innovative scoring system can preoperatively assess treatment success after intrarenal surgery and can be used for preoperative surgical arrangement and comparisons of outcomes among different centers and within a center over time.

CHOICE Internal report I-4: The current status of ICT R&D&I for Chinese Eco-Cities

OpenAIRE

Owens, TJ; Itagaki, T

2015-01-01

This report attempts to give a flavour of the current of status of ICT R&D&I for Chinese Eco-cities and thereby provide some insights into the potential of China’s emerging market for Eco-city solutions for EU- China collaborative ICT R&D&I. It addresses Eco-city standards development in China. Evaluation Centres for Eco-City software solutions, the context into which ICT for Chinese Eco-cities fits, Chinese ICT R&D in smart cities, EU-China collaboration in ICT R&D smart cities, EU Member st...

Rare muon processes: Experiment

International Nuclear Information System (INIS)

Walter, H.K.

1998-01-01

The decay properties of muons, especially their rare decays, can be used to study very accurately deviations from the Standard Model. Muons with extremely low energies and good spatial definition are preferred for the majority of such studies. With the upgrade of the 590-MeV ring accelerator, PSI possesses the most powerful cyclotron in the world. This makes it possible to operate high-intensity beams of secondary pions and muons. A short review on rare muon processes is presented, concerning μ-e conversion and muonium-antimuonium oscillations. A possible new search for μ→eγ is also mentioned

X-ray crystal structures of the pheromone-binding domains of two quorum-hindered transcription factors, YenR of <i>Yersinia enterocoliticai> and CepR2 of <i>Burkholderia cenocepaciai>: KIM et al.

Energy Technology Data Exchange (ETDEWEB)

Kim, Youngchang [Midwest Center for Structural Genomics, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Chhor, Gekleng [Midwest Center for Structural Genomics, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Tsai, Ching-Sung [Department of Microbiology, Cornell University, Ithaca New York 14853; Fox, Gabriel [Department of Microbiology, Cornell University, Ithaca New York 14853; Chen, Chia-Sui [Department of Microbiology, Cornell University, Ithaca New York 14853; Winans, Nathan J. [Department of Microbiology, Cornell University, Ithaca New York 14853; Jedrzejczak, Robert [Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Joachimiak, Andrzej [Midwest Center for Structural Genomics, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne Illinois 60439; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago Illinois 60637; Winans, Stephen C. [Department of Microbiology, Cornell University, Ithaca New York 14853

2017-07-24

The ability of LuxR-type proteins to regulate transcription is controlled by bacterial pheromones, N-acylhomoserine lactones (AHLs). Most LuxR-family proteins require their cognate AHLs for activity, and some of them require AHLs for folding and stability, and for protease-resistance. However, a few members of this family are able to fold, dimerize, bind DNA, and regulate transcription in the absence of AHLs; moreover, these proteins are antagonized by their cognate AHLs. One such protein is YenR of Yersinia enterocolitica, which is antagonized by N-3-oxohexanoyl-l-homoserine lactone (OHHL). This pheromone is produced by the OHHL synthase, a product of the adjacent yenI gene. Another example is CepR2 of Burkholderia cenocepacia, which is antagonized by N-octanoyl-l-homoserine lactone (OHL), whose synthesis is directed by the cepI gene of the same bacterium. Here, we describe the high-resolution crystal structures of the AHL binding domains of YenR and CepR2. YenR was crystallized in the presence and absence of OHHL. While this ligand does not cause large scale changes in the YenR structure, it does alter the orientation of several highly conserved YenR residues within and near the pheromone-binding pocket, which in turn caused a significant movement of a surface-exposed loop.

New challenges to public utilities. Shaping change - first German I.I.R. energy congress in Wiesbaden on 21/22 March 1995; Neue Herausforderungen in der Versorgungswirtschaft. Den Wandel gestalten - 1. Deutscher I.I.R.-Energiekongress am 21./22. Maerz 1995 in Wiesbaden

Energy Technology Data Exchange (ETDEWEB)

Lamprecht, F

1995-05-01

The issues discussed at the First German I.I.R. Energy Congress comprise various aspects of a public supplies system undergoing conversion: changed framework conditions; customer grooming measures in core business areas; diversification into appropriate new fields of business; consequences of these processes for personnel management; and steering and control of the transformation process through efficient Controlling. The congress was organised jointly by the Institute for International Research (I.I.R.) and ``et``. It attracted around 250 participants and was flanked by the proclamation of the 1995 Energy Management Award. (orig.) [Deutsch] Aktuelle Aspekte der Versorgungswirtschaft im Umbruch, von den veraenderten Rahmenbedingungen ueber Kundenbindungsmassnahmen im Stammgeschaeft, Diversifikation in geeignete neue Geschaeftsfelder, die Konsequenzen dieser Prozesse fuer die Personalwirtschaft, bis zur Steuerung und Kontrolle der Transformation durch effizientes Controlling, waren Thema des 1. Deutschen I.I.R.-Energiekongresses, gemeinsam ausgerichtet vom Institute for International Research (I.I.R) und der ``et``. Die Verleihung des Energie Management Award `95 sowie eine Fachausstellung flankierten die von rund 250 Teilnehmern besuchte Veranstaltung. (orig.)

Görüntü Eşleme ve Genetik Algoritmalar Kullanarak Görüntü içinde Görüntü Arama

Directory of Open Access Journals (Sweden)

Mehmet Karakoc

2015-10-01

Full Text Available Bu çalışmada esas alınan problem, görüntü içinde görüntü aramayı etkin bir şekilde gerçekleştirebilmektir. Bu amaçla görüntü işleme kapsamında yer alan görüntü eşleme teknikleri ile arama algoritmaları birlikte kullanılmıştır. Görüntü eşleme için Yapay Sinir Ağları ile görüntünün ortalama renk değeri, görüntüdeki renk değerlerinin standart sapması, korelasyon ve görüntü kenar parametreleri gibi özellikler; görüntü arama için Genetik Algoritmalar kullanılmıştır. Bu çalışmada, akıllı arama algoritmaları, hızlı görüntü eşleme yöntemleri ve paralel programlama tekniklerine dayanan bütünleşik bir yöntem önerilmiş ve kullanılmıştır. Önerilen yöntem çok sayıda düşük ve yüksek çözünürlüklü referans ve şablon görüntü üzerinde test edilmiştir. Elde edilen sonuçlar önerilen yöntemin eşleşen görüntüleri elde etmede başarılı olduğunu ve toplam arama süresini azalttığını göstermiştir.

Progress report I.R.S.N. 2003

International Nuclear Information System (INIS)

2003-01-01

This report is divided in six chapters. The first one is devoted to the safety of civil installations, transport and radioactive wastes. In this chapter we find the safety of PWR type reactors, the safety of Cabri reactor, ITER tokamak, the storage of radioactive waste and the criticality of packages with actinides. The second chapter concerns the protection of man and environment, we find the radiation monitoring of workers, the medical management of irradiated personnel, the radiation protection of nuclear power plants. The third chapter is relative to the national defense. The fourth chapter tackles the international relations and the part taken by I.R.S.N. in the Europe construction. The fifth chapter gives the contribution to public information, communication and training. The sixth and last chapter explains the quality policy at I.R.S.N. and how the management is made by a quality option. (N.C.)

Når det er svært at være ung i DK

DEFF Research Database (Denmark)

Nielsen, Jens Christian; Sørensen, Niels Ulrik; Ozmec, Martha Nina

I rapporten Når det er svært at være ung i DK – unges trivsel og mistrivsel i tal offentliggør Center for Ungdomsforskning resultaterne af en stor videnskabelig spørgeskemaundersøgelse om trivsel og mistrivsel blandt 15-24-årige unge i Danmark. Rapporten indgår i det treårige forskningsprojekt Når...... det er svært at være ung i DK, som Center for Ungdomsforskning udfører med støtte fra Egmont Fonden. Rapporten bygger på telefoninterviews med 3.481 unge, der udgør et repræsentativt udsnit af alle 15-24-årige unge i Danmark. I rapporten forfølges de unges trivsel og mistrivsel gennem to spor: 1) Et...

A Rare Cause of Abdominal Pain in Childhood: Cardiac Angiosarcoma

Directory of Open Access Journals (Sweden)

Elvan Caglar Citak

Full Text Available Abstract Cardiac angiosarcomas are extremely rare in childhood, they are rapidly progressive tumours that often present themselves as diagnostic dilemmas, resulting in delayed diagnosis. Also, extracardiac manifestations, including abdominal pain, are extremely rare in patients with intracardiac tumors. We herein present the case of a 15-year-old girl who presented with abdominal pain. Echocardiography and thoracic computed tomography showed right atrial mass. The patient underwent surgery, chemotherapy, and radiotherapy. Eight months after treatment, abdominal recurrence was detected. The abdominal mass was resected, and radiotherapy and new chemotherapy protocol were given. The present case illustrates a rare case of primary cardiac angiosarcoma posing a diagnostic dilemma in an adolescent girl.

Løven, ræven og machiavellisk politik i Game of Thrones

DEFF Research Database (Denmark)

Schubart, Rikke

2013-01-01

Blogindlæg om machiavelliske følelser i tv-serien Game of Thrones (2013) på videnskab.dk, "Løven, ræven og machiavellisk politik i Game of Thrones"......Blogindlæg om machiavelliske følelser i tv-serien Game of Thrones (2013) på videnskab.dk, "Løven, ræven og machiavellisk politik i Game of Thrones"...

Nyttan av franchising i den svenska fastighetsmäklarbranschen

OpenAIRE

Herke, Marie; Olivers, Marielle

2012-01-01

Franchising är det mest vanliga kedjekonceptet i fastighetsmäklarbranschen och flera av de största fastighetsmäklarkedjorna är franchisekedjor. De fristående mäklarbyråerna får allt svårare att klara sig i den ökade konkurrensen. Det är främst fristående mäklarbyråer på mindre orter med ett etablerat varumärke samt nischade mäklarbyråer som klarar sig i konkurrensen med de stora kedjorna. På senare år har antalet kedjeanslutna fastighetsmäklare ökat betydligt och flertalet av mäklarkedjorna ä...

Serous Carcinoma of the Uterine Cervix, an Extremely Rare Aggressive Entity: A Literature Review.

Science.gov (United States)

Jonska-Gmyrek, Joanna; Zolciak-Siwinska, Agnieszka; Gmyrek, Leszek; Michalski, Wojciech; Poniatowska, Grazyna; Fuksiewicz, Malgorzata; Wiechno, Pawel; Kucharz, Jakub; Kowalska, Maria; Kotowicz, Beata

2018-01-23

Serous carcinoma of the uterine cervix (USCC) is an extremely rare subtype. To establish the treatment strategy in patients with USCC is an important issue. MEDLINE (PubMed) was searched for all articles published after the first publication by Lurie et al. [Eur J Obstet Gynecol Reprod Biol 1991; 40: 79-81], reporting woman diagnosed with USCC. Because of limited numbers of studies on the topic of the study, we could not keep a restriction of eliminating smaller sample sizes. A search of PubMed demonstrated that 113 cases of USCC have been reported in the literature since the first publication. The current treatment modality adopted for early cervical cancer is hysterectomy with bilateral iliac-obturator lymphadenectomy and postoperative radiotherapy (RT) or radiochemotherapy (RT-CT) if risk factors for cervical carcinoma appear. The treatment strategy for locally advanced USCC is preoperative RT-CT or chemotherapy (CHTH) with the intention to treat the patient surgically. The treatment option for disseminated disease is CHTH with paclitaxel and carboplatin. Risk factors and a more advanced clinical stage of USCC have an impact on poor outcomes despite the use of standard treatment methods, adapted for cervical cancer. The outside-pelvic failures tend to seek effective systemic treatment. © 2018 S. Karger AG, Basel.

Hydrologic Tests at Characterization Wells R-9i, R-13, R-19, R-22, and R-31, Revision 1

Energy Technology Data Exchange (ETDEWEB)

S.G.McLin; W.J. Stone

2004-06-01

Hydrologic information is essential for environmental efforts at Los Alamos National Laboratory. Testing at new characterization wells being drilled to the regional aquifer (''R wells'') to improve the conceptual hydrogeologic model of the Pajarito Plateau is providing such information. Field tests were conducted on various zones of saturation penetrated by the R wells to collect data needed for determining hydraulic properties. This document provides details of the design and execution of testing as well as an analysis of data for five new wells: R-9i, R-13, R-19, R-22, and R-31. One well (R-13) was evaluated by a pumping test and the rest (R-9i, R-19, R-22, and R-31) were evaluated by injection tests. Characterization well R-9i is located in Los Alamos Canyon approximately 0.3 mi west of the Route 4/Route 502 intersection. It was completed at a depth of 322 ft below ground surface (bgs) in March 2000. This well was constructed with two screens positioned below the regional water table. Both screens were tested. Screen 1 is completed at about 189-200 ft bgs in fractured basalt, and screen 2 is completed at about 270-280 ft bgs in massive basalt. Specific capacity analysis of the screen 1 data suggests that the fractured basalt has a transmissivity (T) of 589 ft{sup 2}/day and corresponds to a hydraulic conductivity (K) of 7.1 ft/day based on a saturated thickness of 83 ft. The injection test data from the massive basalt near screen 2 were analyzed by the Bouwer-Rice slug test methodology and suggest that K is 0.11 ft/day, corresponding to a T of about 2.8 ft{sup 2}/day based on a saturated thickness of 25 ft. Characterization well R-13 is located in Mortandad Canyon just west of the eastern Laboratory boundary. It was completed at a depth of 1029 ft bgs in February 2002. This well was constructed with one 60-ft long screen positioned about 125 ft below the regional water table. This screen is completed at about 958-1019 ft bgs and straddles the

Macrodystrophia Lipomatosa: A rare presentation | Kachewar ...

African Journals Online (AJOL)

Macrodystrophia lipomatosa is a rare congenital nonhereditary mesenchymal hamartomatous malformation resulting in localized gigantism of parts of extremities that manifests clinically as macrodactyly or megalodactyly. Radiological and Pathological hallmark is the disproportionate fibroadipose tissue proliferation in ...

Modified Inverse First Order Reliability Method (I-FORM) for Predicting Extreme Sea States.

Energy Technology Data Exchange (ETDEWEB)

Eckert-Gallup, Aubrey Celia; Sallaberry, Cedric Jean-Marie; Dallman, Ann Renee; Neary, Vincent Sinclair

2014-09-01

Environmental contours describing extreme sea states are generated as the input for numerical or physical model simulation s as a part of the stand ard current practice for designing marine structure s to survive extreme sea states. Such environmental contours are characterized by combinations of significant wave height ( ) and energy period ( ) values calculated for a given recurrence interval using a set of data based on hindcast simulations or buoy observations over a sufficient period of record. The use of the inverse first - order reliability method (IFORM) i s standard design practice for generating environmental contours. In this paper, the traditional appli cation of the IFORM to generating environmental contours representing extreme sea states is described in detail and its merits and drawbacks are assessed. The application of additional methods for analyzing sea state data including the use of principal component analysis (PCA) to create an uncorrelated representation of the data under consideration is proposed. A reexamination of the components of the IFORM application to the problem at hand including the use of new distribution fitting techniques are shown to contribute to the development of more accurate a nd reasonable representations of extreme sea states for use in survivability analysis for marine struc tures. Keywords: In verse FORM, Principal Component Analysis , Environmental Contours, Extreme Sea State Characteri zation, Wave Energy Converters

Megatrend analaysis of the health policies of I.R.Iran

Directory of Open Access Journals (Sweden)

Iraj Nabipour

2014-11-01

Full Text Available Background: Megatrends are long-lasting global developments in society, technology, economy and political conditions that their effects are not restricted to a particular geographic area. In future studies, megatrends in social, technology, environment, politics, and values (STEEP-V should be considered. Material and Methods: The megatrends shaping healthcare in the new millennium were selected from the future studies. Trend analysis (macro to micro approach was used to emerge key fields of action or areas of innovation in healthcare and related technologies that might be reflected in the health policies of I.R.Iran. Results: Ten megatrends shaping healthcare in the new millennium were identified. High capacities for innovation in emerging health technologies, policies for health insurance, paradigm shift from volume to value in healthcare delivery, and infrastructure for participatory medicine were found in the health policies of I.R.Iran. Conclusions: The majority of the health policies of I.R.Iran are in line of healthcare megatrends and these policies provide a great potential for healthcare reform. However, more emphasis should be paid on mobile health (m-Health, medical tourism, community-based medicine, systems medicine, personalized medicine, transformation of big data to knowledge and geriatric health in the health policies of I.R.Iran.

Competing Structural Instabilities in the Ruddlesden–Popper Derivatives HRTiO4 (R = Rare Earths): Oxygen Octahedral Rotations Inducing Noncentrosymmetricity and Layer Sliding Retaining Centrosymmetricity

International Nuclear Information System (INIS)

Sen Gupta, Arnab; Akamatsu, Hirofumi; Brown, Forrest G.; Nguyen, Minh An T.

2016-01-01

We report the discovery of noncentrosymmetry in the family of HRTiO 4 (R = Eu, Gd, Dy) layered oxides possessing a Ruddlesden-Popper derivative structure, by second harmonic generation and synchrotron x-ray diffraction with the support of density functional theory calculations. These oxides were previously thought to possess inversion symmetry. Here, inversion symmetry is broken by oxygen octahedral rotations, a mechanism that is not active in simple perovskites. We discover a competition between oxygen octahedral rotations and sliding of the octahedral perovskite blocks at the OH layers. For the smaller rare earth ions, R = Eu, Gd, Dy, which favor the octahedral rotations, noncentrosymmetry is present but the sliding at the OH layer is absent. For the larger rare earth ions, R = Nd and Sm, the octahe-dral rotations are absent, but sliding of the octahedral blocks at the OH layer is present, likely to optimize the hydrogen bond length arising from the directional nature of these bonds in the crystal structure. The study reveals a new mechanism for inducing noncentrosymmetry in layered oxides, and chemical-structural effects related to rare earth ion size and hydrogen bonding that can turn this mechanism on and off. In conclusion, we construct a complete phase diagram of temperature versus rare earth ionic radius for the HRTiO 4 family.

Extreme interplanetary rotational discontinuities at 1 AU

Science.gov (United States)

Lepping, R. P.; Wu, C.-C.

2005-11-01

This study is concerned with the identification and description of a special subset of four Wind interplanetary rotational discontinuities (from an earlier study of 134 directional discontinuities by Lepping et al. (2003)) with some "extreme" characteristics, in the sense that every case has (1) an almost planar current sheet surface, (2) a very large discontinuity angle (ω), (3) at least moderately strong normal field components (>0.8 nT), and (4) the overall set has a very broad range of transition layer thicknesses, with one being as thick as 50 RE and another at the other extreme being 1.6 RE, most being much thicker than are usually studied. Each example has a well-determined surface normal (n) according to minimum variance analysis and corroborated via time delay checking of the discontinuity with observations at IMP 8 by employing the local surface planarity. From the variance analyses, most of these cases had unusually large ratios of intermediate-to-minimum eigenvalues (λI/λmin), being on average 32 for three cases (with a fourth being much larger), indicating compact current sheet transition zones, another (the fifth) extreme property. For many years there has been a controversy as to the relative distribution of rotational (RDs) to tangential discontinuities (TDs) in the solar wind at 1 AU (and elsewhere, such as between the Sun and Earth), even to the point where some authors have suggested that RDs with large ∣Bn∣s are probably not generated or, if generated, are unstable and therefore very rare. Some of this disagreement apparently has been due to the different selection criteria used, e.g., some allowed eigenvalue ratios (λI/λmin) to be almost an order of magnitude lower than 32 in estimating n, usually introducing unacceptable error in n and therefore also in ∣Bn∣. However, we suggest that RDs may not be so rare at 1 AU, but good quality cases (where ∣Bn∣ confidently exceeds the error in ∣Bn∣) appear to be uncommon, and further

Orbital lymphomatoid granulomatosis - a rare cause of proptosis

Energy Technology Data Exchange (ETDEWEB)

Du Toit, Jacqueline; Kilborn, Tracy [Department of Radiology, Red Cross Children' s Hospital, Rondebosch (South Africa); Eyssen, Ann van [Department of Oncology, Red Cross Children' s Hospital, Rondebosch (South Africa); Pillay, Komala [Department of Pathology, Red Cross Children' s Hospital, Rondebosch (South Africa)

2015-07-15

A 1-year-old girl with unilateral proptosis was found to have primary orbital lymphomatoid granulomatosis - a condition rarely occurring in children. This multisystem angiocentric, angiodestructive, lymphoproliferative disease typically involves the lungs, with ocular involvement being extremely uncommon. Our case serves to illustrate the imaging findings of this unusual condition and highlight a rare cause of proptosis. (orig.)

Hvordan foregår mesterlære i elitesport?

DEFF Research Database (Denmark)

Lund, Ole

af afhandlingen består af et multi-case studie af tre elitesportskontekster i Danmark. De tre cases består af henholdsvis en dame dobbeltsculler, et mandligt trampolin-synkron-par og et kvindeligt håndboldhold. Disse konstellationer befinder sig alle på et højt internationalt niveau. Afhandlingens...

Rare earth elements and permanent magnets (invited)

Science.gov (United States)

Dent, Peter C.

2012-04-01

Rare earth (RE) magnets have become virtually indispensible in a wide variety of industries such as aerospace, automotive, electronics, medical, and military. RE elements are essential ingredients in these high performance magnets based on intermetallic compounds RECo5, RE2TM17 (TM: transition metal), and RE2TM14B. Rare earth magnets are known for their superior magnetic properties—high induction, and coercive force. These properties arise due to the extremely high magnetocrystalline anisotropy made possible by unique 3d-4f interactions between transition metals and rare earths. For more than 40 years, these magnets remain the number one choice in applications that require high magnetic fields in extreme operating conditions—high demagnetization forces and high temperature. EEC produces and specializes in RECo5 and RE2TM17 type sintered magnets. Samarium and gadolinium are key RE ingredients in the powder metallurgical magnet production processes which include melting, crushing, jet milling, pressing, sintering, and heat treating. The magnetic properties and applications of these magnets will be discussed. We will also briefly discuss the past, current, and future of the permanent magnet business. Currently, over 95% of all pure rare earth oxides are sourced from China, which currently controls the market. We will provide insights regarding current and potential new magnet technologies and designer choices, which may mitigate rare earth supply chain issues now and into the future.

Tree species traits but not diversity mitigate stem breakage in a subtropical forest following a rare and extreme ice storm.

Directory of Open Access Journals (Sweden)

Karin Nadrowski

Full Text Available Future climates are likely to include extreme events, which in turn have great impacts on ecological systems. In this study, we investigated possible effects that could mitigate stem breakage caused by a rare and extreme ice storm in a Chinese subtropical forest across a gradient of forest diversity. We used Bayesian modeling to correct stem breakage for tree size and variance components analysis to quantify the influence of taxon, leaf and wood functional traits, and stand level properties on the probability of stem breakage. We show that the taxon explained four times more variance in individual stem breakage than did stand level properties; trees with higher specific leaf area (SLA were less susceptible to breakage. However, a large part of the variation at the taxon scale remained unexplained, implying that unmeasured or undefined traits could be used to predict damage caused by ice storms. When aggregated at the plot level, functional diversity and wood density increased after the ice storm. We suggest that for the adaption of forest management to climate change, much can still be learned from looking at functional traits at the taxon level.

Massive epistaxis due to pseudoaneurysm of the sphenopalatine artery: a rare post-operative complication of orthognathic surgery.

Science.gov (United States)

Kim, Y-W; Baek, M-J; Kim, H-D; Cho, K-S

2013-06-01

To introduce pseudoaneurysm of the sphenopalatine artery as the possible aetiology of acute massive epistaxis in patients with a history of orthognathic surgery accompanied by Le Fort I osteotomy. Case report and literature review. This paper reports a case of acute life-threatening epistaxis following Le Fort I osteotomy. Computed tomography and angiography showed a pseudoaneurysm of the sphenopalatine artery, which was successfully treated by endovascular embolisation. Although a pseudoaneurysm of the sphenopalatine artery following Le Fort I osteotomy is extremely rare, it should be considered as the possible aetiology of acute massive epistaxis in patients with a history of orthognathic surgery accompanied by Le Fort I osteotomy.

De sociale mediers brugervilkår del I - aftalen

DEFF Research Database (Denmark)

Feldthusen, Rasmus Kristian; Larsen, Torsten Bjørn

2016-01-01

Det Sociale Medium som f.eks. Twitter, Snapchat, Foursquare, Facebook, Instagram, Pinterest, Tinder og Youtube har betinget sig en række standardvilkår som Brugeren, der måtte ønske at oprette en Profil, skal acceptere som led i oprettelsen. Ved at klikke på ”opret profil” eller en hermed...

Correlations fo Sc, rare earths and other elements in selected rock samples from Arrua-i

Energy Technology Data Exchange (ETDEWEB)

Facetti, J F; Prats, M [Asuncion Nacional Univ. (Paraguay). Inst. de Ciencias

1972-01-01

The Sc and Eu contents in selected rocks samples from the stock of Arrua-i have been determined and correlations established with other elements and with the relative amount of some rare earths. These correlations suggest metasomatic phenomena for the formation of the rock samples.

Correlations fo Sc, rare earths and other elements in selected rock samples from Arrua-i

International Nuclear Information System (INIS)

Facetti, J.F.; Prats, M.

1972-01-01

The Sc and Eu contents in selected rocks samples from the stock of Arrua-i have been determined and correlations established with other elements and with the relative amount of some rare earths. These correlations suggest metasomatic phenomena for the formation of the rock samples

"Jag tror ju på allas lika värde oavsett kön" En studie om hur förskollärares resonemang kring sitt jämställdhetsuppdrag kommer till uttryck i mötet med barn.

OpenAIRE

Gisslén, Mia

2013-01-01

Denna studie har som syfte att belysa relationen mellan förskollärares resonemang om sitt jämställdhetsuppdrag och hur det kommer till uttryck i det direkta mötet med barn. Studiens empiri har samlats ihop genom två halvstrukturerade intervjuer med två förskollärare och tre löpande observationer i samlingssituation vid en förskola. Resultatet visar att förskollärarna resonerar kring sitt jämställdhetsuppdrag på ett professionellt sätt. De visar hög medvetenhet när de resonerar om sitt jämstäl...

Før trafikken går i stå

DEFF Research Database (Denmark)

Tiedemann, Ernst; Jespersen, Per Homann; Kristensen, Niels Buus

energibærere (biobrændstoffer, brint)1, etablering og vedligeholdelse af fysisk transportinfrastruktur (veje, skinner, broer, tunneller, havne, etc.), udvikling af mere miljø- og sundhedsrigtig transport (støjbekæmpelse, partikelfiltre, lokale visioner for at udbrede cykling og gang, etc.) og spørgsmål om...... oplevelse. Hvis vækst og arbejdspladser skal fastholdes i Danmark, er det helt centralt at kunne udvikle transportens fordele og samtidig reducere dens skadevirkninger. Det kræver ambitiøse målsætninger og politisk evne og vilje tilhandling. Formålet med denne ATV-rapport er at formulere visioner for...... transportinvesteringer? Der skal arbejdes på tværs af sektorer, hvis det danske samfund skal på forkant i en udvikling præget af stigende efterspørgsel på transport. Både hvad angår person- og godstransport, ndividuel og kollektiv transport. Der skal formuleres sammenhængende visioner, som er uafhængige af de...

Event-adjusted evaluation of weather and climate extremes

Czech Academy of Sciences Publication Activity Database

Müller, Miloslav; Kašpar, Marek

2014-01-01

Roč. 14, č. 2 (2014), s. 473-483 ISSN 1561-8633 R&D Projects: GA ČR(CZ) GAP209/11/1990 Institutional support: RVO:68378289 Keywords : weather extreme * climate extreme * extremity evaluation * return period * generalized extreme value distribution * region of influence Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 1.735, year: 2014 http://www.nat-hazards- earth -syst-sci.net/14/473/2014/nhess-14-473-2014.pdf

GUIer gør godt - Introduktion til GUIer i Matlab

DEFF Research Database (Denmark)

Jacobsen, Niels Gjøl

2003-01-01

GUI er en forkortelse for 'Graphical User Interface', og det er en særdeles nyttig måde at visualisere sine data, og det gør det ligeledes på en simpel måde muligt at ændre enkelte parametrer i beregninger og se de fysiske, matematiske eller andre ændringer, som sker i forbindelse med ændringen a...... disse parametrer. Ydermere hjælper GUIer til, at der bliver skabt en grænse for, hvor meget brugeren kan ændre i programmet, da der ikke direkte kontakt til den bagvedliggende kode. Denne introduktion er skrevet til Matlab 6.5. R13....

Congenital agenesis of unilateral parotid gland with ipsilateral type I first branchial cleft anomaly: A rare presentation

OpenAIRE

Tripti Maithani; Apoorva Pandey; Seema Acharya

2014-01-01

Aim: To report a rare case of unilateral parotid agenesis with ipsilateral type I first branchial cleft anomaly. Material and methods: A case study with special emphasis on the embryology, outlining the complex developmental process of parotid and branchial arches and highlighting the probable reason for development of such anomalies. Results: The literature states that unilateral parotid agenesis is a rare entity with few reported cases occurring solely or in conjunction with other hea...

E-st@r-I experience: Valuable knowledge for improving the e-st@r-II design

Science.gov (United States)

Corpino, S.; Obiols-Rabasa, G.; Mozzillo, R.; Nichele, F.

2016-04-01

Many universities all over the world have now established hands-on education programs based on CubeSats. These small and cheap platforms are becoming more and more attractive also for other-than-educational missions, such as technology demonstration, science applications, and Earth observation. This new paradigm requires the development of adequate technology to increase CubeSat performance and mission reliability, because educationally-driven missions have often failed. In 2013 the ESA Education Office launched the Fly Your Satellite! Programme which aims at increasing CubeSat mission reliability through several actions: to improve design implementation, to define best practices for conducting the verification process, and to make the CubeSat community aware of the importance of verification. Within this framework, the CubeSat team at Politecnico di Torino developed the e-st@r-II CubeSat as follow-on of the e-st@r-I satellite, launched in 2012 on the VEGA Maiden Flight. E-st@r-I and e-st@r-II are both 1U satellites with educational and technology demonstration objectives: to give hands-on experience to university students and to test an active attitude determination and control system based on inertial and magnetic measurements with magnetic actuation. This paper describes the know-how gained thanks to the e-st@r-I mission, and how this heritage has been translated into the improvement of the new CubeSat in several areas and lifecycle phases. The CubeSat design has been reviewed to reduce the complexity of the assembly procedure and to deal with possible failures of the on-board computer, for example re-coding the software in the communications subsystem. New procedures have been designed and assessed for the verification campaign accordingly to ECSS rules and with the support of ESA specialists. Different operative modes have been implemented to handle some anomalies observed during the operations of the first satellite. A new version of the on-board software is

Stadig skuldersår i strong>danske sobesætningerstrong>sobesætninger

DEFF Research Database (Denmark)

Bonde, Marianne

2009-01-01

Ny undersøgelse viser, at 17,2 procent af 3.831 diegivende søer i 98 forskellige, danske besætninger havde skuldersår. Hovedparten af skuldersårene var overfladiske, men dybe skuldersår (grad 3-4) blev fundet i næsten hver tredje besætning. Udgivelsesdato: 15. februar 2009......Ny undersøgelse viser, at 17,2 procent af 3.831 diegivende søer i 98 forskellige, danske besætninger havde skuldersår. Hovedparten af skuldersårene var overfladiske, men dybe skuldersår (grad 3-4) blev fundet i næsten hver tredje besætning. Udgivelsesdato: 15. februar 2009...

Structural, optical and spectroscopical investigations into rare-earths perowskites RGaO{sub 3} (R=La, Pr, Nd) and NdBa-2Cu{sub 3}O{sub 7-{delta}}; Strukturelle, optische und spektroskopische Untersuchungen von Seltenen-Erd-Perowskiten RGaO{sub 3} (R=La, Pr, Nd) und NdBa{sub 2}Cu{sub 3}O{sub 7-{delta}}

Energy Technology Data Exchange (ETDEWEB)

Marti, W. [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

1995-07-01

In this work I was engaged in rare-earth perovskites. Primarily I investigated the structure of the rare-earth gallates RGaO{sub 3} (R=La, Pr, Nd) as a function of the temperature by means of neutron diffraction and x-ray diffraction. As the high-T{sub c} superconductors these compounds belong to the family of the perovskites, they are ferroelastic and centro-symmetric. Because of the lanthanide-contraction all lattice constants and distortion parameters change systematically. The rare-earth-gallates RGaO{sub 3} (R=La, Pr, Nd) are promising substrates for epitaxy of high-T{sub c} superconductors like RBa{sub 2}Cu{sub 3}OO{sub 7-{delta}} because of their structure parameters and expansion coefficients. I succeeded in producing plane-parallel single-domain crystals by means of uniaxial stress. The first order phase transition was observable only in LaGaO{sub 3}. A structurally phase transition from orthorhombic to rhombohedral symmetry (high-temperature phase) occurs at 423 K. The hysteresis of the phase transition temperature of about 1.5 K was measured with single-domain crystals by means of neutron diffraction and polarized light microscopy. In NdGaO{sub 3} we determined the long-range, three-dimensional, antiferromagnetic ordering of the Nd{sup 3+}-ions below the ordering temperature at T{sub N}=0.97 K by means of magnetic neutron diffraction. The spin configuration could be described by a (--c{sub z})-mode. Measurements of the magnetic susceptibility confirm the easy direction of magnetization to be the c-axis. Below 300mK an additional nuclear spin polarization due to the hyperfine-interaction appears parallel to the electronic spins, which amounts to 70% at 10mK. Further I investigated the optical properties of the rare-earth gallates. The birefringence of plane-parallel, polished single-domain crystals with thickness up to 300 {mu}m was measured by means of orthoscopy and conoscopy. (author) figs., tabs., refs.

Upper-extremity phocomelia reexamined: a longitudinal dysplasia.

Science.gov (United States)

Goldfarb, Charles A; Manske, Paul R; Busa, Riccardo; Mills, Janith; Carter, Peter; Ezaki, Marybeth

2005-12-01

In contrast to longitudinal deficiencies, phocomelia is considered a transverse, intercalated segmental dysplasia. Most patients demonstrate severe, but not otherwise classifiable, upper-extremity deformities, which usually cannot be placed into one of three previously described phocomelia groups. Additionally, these phocomelic extremities do not demonstrate true segmental deficits; the limb is also abnormal proximal and distal to the segmental defect. The purpose of this investigation was to present evidence that upper-extremity abnormalities in patients previously diagnosed as having phocomelia in fact represent a proximal continuum of radial or ulnar longitudinal dysplasia. The charts and radiographs of forty-one patients (sixty extremities) diagnosed as having upper-extremity phocomelia were reviewed retrospectively. On the basis of the findings on the radiographs, the disorders were categorized into three groups: (1) proximal radial longitudinal dysplasia, which was characterized by an absent proximal part of the humerus, a nearly normal distal part of the humerus, a completely absent radius, and a radial-sided hand dysplasia; (2) proximal ulnar longitudinal dysplasia, characterized by a short one-bone upper extremity that bifurcated distally and by severe hand abnormalities compatible with ulnar dysplasia; and (3) severe combined dysplasia, with type A characterized by an absence of the forearm segment (i.e., the radius and ulna) and type B characterized by absence of the arm and forearm (i.e., the hand attached to the thorax). Twenty-nine limbs in sixteen patients could be classified as having proximal radial longitudinal dysplasia. Systemic medical conditions such as thrombocytopenia-absent radius syndrome were common in those patients, but additional musculoskeletal conditions were rare. Twenty limbs in seventeen patients could be classified as having proximal ulnar longitudinal dysplasia. Associated musculoskeletal abnormalities, such as proximal femoral

Evidence for an active rare biosphere within freshwater protists community.

Science.gov (United States)

Debroas, Didier; Hugoni, Mylène; Domaizon, Isabelle

2015-03-01

Studies on the active rare biosphere at the RNA level are mainly focused on Bacteria and Archaea and fail to include the protists, which are involved in the main biogeochemical cycles of the earth. In this study, the richness, composition and activity of the rare protistan biosphere were determined from a temporal survey of two lakes by pyrosequencing. In these ecosystems, the always rare OTUs represented 77.2% of the total OTUs and 76.6% of the phylogenetic diversity. From the various phylogenetic indices computed, the phylogenetic units (PUs) constituted exclusively by always rare OTUs were discriminated from the other PUs. Therefore, the rare biosphere included mainly taxa that are distant from the reference databases compared to the dominant ones. In addition, the rarest OTUs represented 59.8% of the active biosphere depicted by rRNA and the activity (rRNA:rDNA ratio) increased with the rarity. The high rRNA:rDNA ratio determined in the rare fraction highlights that some protists were active at low abundances and contribute to ecosystem functioning. Interestingly, the always rare and active OTUs were characterized by seasonal changes in relation with the main environmental parameters measured. In conclusion, the rare eukaryotes represent an active, dynamic and overlooked fraction in the lacustrine ecosystems. © 2015 John Wiley & Sons Ltd.

Experimental evidence of the impact of rare-earth elements on particle growth and mechanical behaviour of silicon nitride

International Nuclear Information System (INIS)

Satet, Raphaelle L.; Hoffmann, Michael J.; Cannon, Rowland M.

2006-01-01

The impact of various rare-earth and related doping elements (R = Lu, Sc, Yb, Y, Sm, La) on the grain growth anisotropy and the mechanical properties of polycrystalline β-silicon nitride ceramics has been studied. Model experiments, in which Si 3 N 4 particles can grow freely in an R-Si-Mg-oxynitride glass matrix, show that, with increasing ionic radius of the additive, grain anisotropy increases due to non-linear growth kinetics. Toughness and strength are affected by the rare-earth element. Samples of equivalent grain sizes and morphologies yield an increasing toughness with increasing ion size of the R 3+ , reflecting an increasingly intergranular crack path. These samples are also strong and flaw tolerant, but the trends of strength and toughness do not exactly match. The choice of the rare-earth is essential to tailor microstructure, interfacial strength and mechanical properties. However, somewhat different trends for properties from IIIb and lanthanide additives indicate that more than the R 3+ size (i.e., purely ionic bond strength between R 3+ and its neighbours) is important. The electronic structure of the R-element is responsible for the type of dopant adsorption and the properties of the interface

Vad och hur gör de? − att synliggöra lärande i grundskolans slöjdpraktik via videoetnografi och mikroanalys

Directory of Open Access Journals (Sweden)

Marléne Johansson

2011-11-01

Full Text Available Artikeln bygger på resultat och erfarenheter av etnografiskt insamlade videoinspelningar från grundskolans slöjdundervisning utgående från tre studier; dels vid ett projekt med förstudier under slutet av 1990-talet (Johansson, 1996, dels vid avhandlingsprojektet Slöjdpraktik i skolan (Johansson, 2002 och dels inom forskningsprojektet Kommunikation och lärande i slöjdpraktiker, (”Komolär-projektet”, under 2005−2010 (Lindström, Borg, Johansson & Lindberg, 2003.Att insamla empiri i autentiska slöjdmiljöer är av intresse då lärandesituationer kan synliggöras när elever med hjälp av material och redskap arbetar med att tillverka artefakter. Utifrån detaljerade analyser av slöjdaktiviteter går det att upptäcka det som utspelar sig och möjligheter ges att uppfatta något annat jämfört med vad man kan tro känna väl eller ha förenklade och till och med felaktiga uppfattningar om. Videoobservationer möjliggör att antaganden istället görs på empiriskt grundat datamaterial. Med risk att videofilma och analysera det man tror sig veta och söka har forskningsprojektens insamlingar mer förutsättningslöst arbetat efter vad och hur elever och lärare gör i slöjdpraktik och vad man får veta när slöjdaktiviteter analyseras mer ingående. Videomaterialen har analyserats både på en mer övergripande nivå och detaljerat med hjälp av mikroanalyser. Därefter har lärandet synliggjorts och beskrivits bland annat i teman för att visa hur personerna är resurser för varandra och hur lärandet utvecklas genom olika språkanvändning och med slöjdpraktikens fysiska redskap och material.Sökord: metod, slöjd, klassrumsforskning, videoetnografi, mikroanalysURN:NBN:no-29955

E.X.T.R.E.M.E. project. Launch

International Nuclear Information System (INIS)

Eyrolle, F.; Charmasson, S.; Masson, O.

2005-01-01

Due to the drastic decrease in artificial radioactivity levels from primary sources such as atmospheric fallout or industrial releases, radioactive storages constituted in the past within several environmental compartments act today as non negligible secondary sources. These delayed sources are particularly active during extreme weather or climatic events such as rainfalls or atmospheric deposits, floods, storms, etc...that may remove important mass, generate activity levels higher than the predicted ones from modeling based on mean transfer process, and produce in a couple of hours or days fluxes similar to those accrued over several month or years. Extreme aims at assessing the consequences on man and its environment of natural events that generate extreme radioactive stocks and/or fluxes within several environmental compartments (atmosphere, soils, rivers, coastal marine environment and deep sea areas). (authors)

Instability of extremal relativistic charged spheres

International Nuclear Information System (INIS)

Anninos, Peter; Rothman, Tony

2002-01-01

With the question 'Can relativistic charged spheres form extremal black holes?' in mind, we investigate the properties of such spheres from a classical point of view. The investigation is carried out numerically by integrating the Oppenheimer-Volkov equation for relativistic charged fluid spheres and finding interior Reissner-Nordstroem solutions for these objects. We consider both constant density and adiabatic equations of state, as well as several possible charge distributions, and examine stability by both a normal mode and an energy analysis. In all cases, the stability limit for these spheres lies between the extremal (Q=M) limit and the black hole limit (R=R + ). That is, we find that charged spheres undergo gravitational collapse before they reach Q=M, suggesting that extremal Reissner-Nordstroem black holes produced by collapse are ruled out. A general proof of this statement would support a strong form of the cosmic censorship hypothesis, excluding not only stable naked singularities, but stable extremal black holes. The numerical results also indicate that although the interior mass-energy m(R) obeys the usual m/R + as Q→M. In the Appendix we also argue that Hawking radiation will not lead to an extremal Reissner-Nordstroem black hole. All our results are consistent with the third law of black hole dynamics, as currently understood

Attribution of extreme rainfall from Hurricane Harvey, August 2017

NARCIS (Netherlands)

Van Oldenborgh, Geert Jan; Van Der Wiel, Karin; Sebastian, A.G.; Singh, Roop; Arrighi, Julie; Otto, Friederike; Haustein, Karsten; Li, Sihan; Vecchi, Gabriel; Cullen, Heidi

2017-01-01

During August 25-30, 2017, Hurricane Harvey stalled over Texas and caused extreme precipitation, particularly over Houston and the surrounding area on August 26-28. This resulted in extensive flooding with over 80 fatalities and large economic costs. It was an extremely rare event: the return

R I 800. A new cobalt-60 sealed source design

International Nuclear Information System (INIS)

Freijo, Jose L.; Gomez, Gonzalo

2006-01-01

The consolidation of the international market of Co-60 sources and the perspective of its growth has encouraged the development of new types of sealed sources. The model R I 800 is designed for activities up to 65 kCi and allows a large spectrum of capsules with different specific activities. During three years Dioxitek developed the process of fabrication and qualifications to comply the design requirements and succeeded in the product approval. Today, the initial lot at an industrial scale of R I 800 sources is under fabrication and a first partial shipment of 100 kCi to the United Kingdom was successfully carried out at the end of October 2005. The whole lot is for export. Due to the versatility of the R I 800 sealed sources it was possible to use as raw material 1 MCi of Co-60 imported from Russia, irradiated in Leningrad nuclear power plant. (author) [es

BOO-1137-AN EXTREMELY METAL-POOR STAR IN THE ULTRA-FAINT DWARF SPHEROIDAL GALAXY BOOeTES I

International Nuclear Information System (INIS)

Norris, John E.; Yong, David; Gilmore, Gerard; Wyse, Rosemary F. G.

2010-01-01

We present high-resolution (R ∼ 40,000), high-signal-to-noise ratio (20-90) spectra of an extremely metal-poor giant star Boo-1137 in the 'ultra-faint' dwarf spheroidal galaxy (dSph) Booetes I, absolute magnitude M V ∼ -6.3. We derive an iron abundance of [Fe/H] = -3.7, making this the most metal-poor star as yet identified in an ultra-faint dSph. Our derived effective temperature and gravity are consistent with its identification as a red giant in Booetes I. Abundances for a further 15 elements have also been determined. Comparison of the relative abundances, [X/Fe], with those of the extremely metal-poor red giants of the Galactic halo shows that Boo-1137 is 'normal' with respect to C and N, the odd-Z elements Na and Al, the iron-peak elements, and the neutron-capture elements Sr and Ba, in comparison with the bulk of the Milky Way halo population having [Fe/H] ∼<-3.0. The α-elements Mg, Si, Ca, and Ti are all higher by Δ[X/Fe] ∼ 0.2 than the average halo values. Monte Carlo analysis indicates that Δ[α/Fe] values this large are expected with a probability ∼0.02. The elemental abundance pattern in Boo-1137 suggests inhomogeneous chemical evolution, consistent with the wide internal spread in iron abundances we previously reported. The similarity of most of the Boo-1137 relative abundances with respect to halo values, and the fact that the α-elements are all offset by a similar small amount from the halo averages, points to the same underlying galaxy-scale stellar initial mass function, but that Boo-1137 likely originated in a star-forming region where the abundances reflect either poor mixing of supernova (SN) ejecta, or poor sampling of the SN progenitor mass range, or both.

Investigation of chemical bond characteristics, thermal expansion coefficients and bulk moduli of alpha-R2MoO6 and R2Mo2O7 (R = rare earths) by using a dielectric chemical bond method.

Science.gov (United States)

Li, Huaiyong; Zhang, Siyuan; Zhou, Shihong; Cao, Xueqiang

2009-09-01

Theoretical researches are performed on the alpha-R2MoO6 (R = Y, Gd, Tb Dy, Ho, Er, Tm and Yb) and pyrochlore-type R2Mo2O7 (R = Y, Nd, Sm, Gd, Tb and Dy) rare earth molybdates by using chemical bond theory of dielectric description. The chemical bonding characteristics and their relationship with thermal expansion property and compressibility are explored. The calculated values of linear thermal expansion coefficient (LTEC) and bulk modulus agree well with the available experimental values. The calculations reveal that the LTECs and the bulk moduli do have linear relationship with the ionic radii of the lanthanides: the LTEC decreases from 6.80 to 6.62 10(-6)/K and the bulk modulus increases from 141 to 154 GPa when R goes in the order Gd, Tb Dy, Ho, Er, Tm, and Yb in the alpha-R2MoO6 series; while in the R2Mo2O7 series, the LTEC ranges from 6.80 to 6.61 10(-6)/K and the bulk modulus ranges from 147 to 163 GPa when R varies in the order Nd, Sm, Gd, Tb and Dy. Copyright 2008 Wiley Periodicals, Inc.

Når det er svært at være ung i DK

DEFF Research Database (Denmark)

Nielsen, Jens Christian; Sørensen, Niels Ulrik; Grubb, Ane

I rapporten Når det er svært at være ung i DK – unges beretninger om mistrivsel og ungdomsliv præsenteres resultaterne af et kvalitativt studie af mistrivsel og ungdomsliv blandt 15-24-årige unge i Danmark. Studiet bygger på dybdegående interviews med 33 unge fra forskellige dele af landet, der...... fortæller om deres erfaringer med diverse mistrivselsformer, som ensomhed, selvskadende adfærd og mobning, og om deres besvær med at håndtere de krav, udfordringer og muligheder, der i øvrigt præger det moderne ungdomsliv. Studiet indgår i det treårige forskningsprojekt Når det er svært at være ung i DK...

Recurrent rhabdomyolysis and glutaric aciduria type I: a case report and literature review.

Science.gov (United States)

Qian, Gu-Ling; Hong, Fang; Tong, Fan; Fu, Hai-Dong; Liu, Ai-Min

2016-08-01

Glutaric acidemia type I (GA-I) is a rare metabolic disorder caused by mutation of the glutaryl- CoA dehydrogenase (GCDH) gene. The occurrence of rhabdomyolysis with GA-I is extremely rare. We reported a child with recurrent rhabdomyolysis and undiagnosed glutaric acidemia type I (GA-I). And a literature review was performed. A 4.5-year-old girl was admitted to our hospital due to recurrent rhabdomyolysis for 3 times within three years. At the third admission, she was diagnosed with GA-I by biochemical testing and mutation analysis. The girl was found to have a serine to leucine replacement mutation of the GCDH gene in exon 8 at position 764. Other three patients with rhabdomyolysis and GA-I were discovered by literature searching. This report highlights that patients with GA-I may have an increased risk of rhabdomyolysis.

Computer-assisted upper extremity training using interactive biking exercise (iBikE) platform.

Science.gov (United States)

Jeong, In Cheol; Finkelstein, Joseph

2012-01-01

Upper extremity exercise training has been shown to improve clinical outcomes in different chronic health conditions. Arm-operated bicycles are frequently used to facilitate upper extremity training however effective use of these devices at patient homes is hampered by lack of remote connectivity with clinical rehabilitation team, inability to monitor exercise progress in real time using simple graphical representation, and absence of an alert system which would prevent exertion levels exceeding those approved by the clinical rehabilitation team. We developed an interactive biking exercise (iBikE) platform aimed at addressing these limitations. The platform uses a miniature wireless 3-axis accelerometer mounted on a patient wrist that transmits the cycling acceleration data to a laptop. The laptop screen presents an exercise dashboard to the patient in real time allowing easy graphical visualization of exercise progress and presentation of exercise parameters in relation to prescribed targets. The iBikE platform is programmed to alert the patient when exercise intensity exceeds the levels recommended by the patient care provider. The iBikE platform has been tested in 7 healthy volunteers (age range: 26-50 years) and shown to reliably reflect exercise progress and to generate alerts at pre-setup levels. Implementation of remote connectivity with patient rehabilitation team is warranted for future extension and evaluation efforts.

Ergotamine-induced upper extremity ischemia: a case report

Energy Technology Data Exchange (ETDEWEB)

Kim, Man Deuk; Lee, Gun [Bundang CHA General Hospital, Pochon (China); Shin, Sung Wook [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2005-06-15

Ergotamine-induced limb ischemia is an extremely rare case. We present a case of a 64-year-old man, who developed ischemia on the right upper extremity due to long-term use of Ergot for migraine headache. Angiography revealed diffused, smooth, and tapered narrowing of the brachial artery. The patient was successfully treated with intravenous nitroprusside.

Arbejdsmiljøindsatsen i 25 år - succes eller fiasko?

DEFF Research Database (Denmark)

Hasle, Peter; Broberg, Ole; Hvenegaard, Hans

Denne udredning er udarbejdet af CASA på foranledning af arbejdsmiljøudvalget i Ingeniørforeningen i Danmark (IDA). Udvalget har ønsket en indledende udredning om effekterne af den forebyggende arbejdsmiljøindsats i Danmark de sidste 25 år samt nogle bud på, hvordan denne indsats kan styrkes frem...

A new (4, 6)-connected Cu(I) coordination polymer based on rare tetranuclear [Cu4I2] clusters: Synthesis, crystal structure, luminescent and photocatalytic properties

Science.gov (United States)

Cui, Li-Jing; Liu, Chun-Yan; Bian, Ming; Yu, Li-Jun

2018-03-01

A new Cu(I) coordination polymer, namely [Cu5I3(L)2]n (1 HL = 3-(4-pyridyl)-5-(3-pyridyl)-1,2,4-triazolyl), was solvothermally synthesized using CuI, HL and NaI as the starting materials. Single crystal X-ray structural analysis shows that compound 1 features a (4, 6)-connected 3D framework employing rare tetranuclear [Cu4I2] clusters as building subunits. It exhibits intense metal-to-ligand luminescence and excellent photocatalytic activity on degradation of methylene blue (MB).

Variable ultrasonography findings of extremity lymphangioma: Pathologic correlation

International Nuclear Information System (INIS)

Oh, Jong Young; Nam, Kyung Jin; Lee, Ki Nam; Kim, Chan Sung; Lee, Jin Hwa; Kim, Dae Chul

2002-01-01

The great majority of lymphangiomas occur in the neck (75%) and axilla (20%), but extremity lymphangioma is rare. We correlate variable sonographic features of extremity lymphangioma with pathologic findings. We reviewed the sonographic findings of extremity lymphangioma in 14 patients (M:F=8:6). The all cases were histologically confirmed by operation. The variable sonographic features of extremity lymphangioma were compared to pathologic findings. The multilocular cystic mass with ill defined boundaries was distinctive sonographic appearance of extremity lymphangioma. But there were variable sonographic findings such as heterogeneous echogenic mass or homogeneous echogenic portion. The histologic section of echogenic lesion reveals clusters of abnormal

P.R. Subramanian (Chief Editor). <i>Kriyavin Tarkalat Tamil Akarati (Tamil-Tamil-Ankilam) (Dictionary of Contemporary Tamil (Tamil-Tamil-English))i>

OpenAIRE

G. Murugan

2012-01-01

Review of P.R. Subramanian (Chief Editor). <i>Kriyavin Tarkalat Tamil Akarati (Tamil-Tamil-Ankilam) (Dictionary of Contemporary Tamil (Tamil-Tamil-English))i>Resensie van P.R. Subramanian (Chief Editor). <i>Kriyavin Tarkalat Tamil Akarati (Tamil-Tamil-Ankilam) (Dictionary of Contemporary Tamil (Tamil-Tamil-English))i>

Focal neuronal gigantism: a rare complication of therapeutic radiation.

Science.gov (United States)

Gaughen, J R; Bourne, T D; Aregawi, D; Shah, L M; Schiff, D

2009-11-01

Radiation therapy, a mainstay in the treatment of many brain tumors, results in a variety of well-documented acute and chronic complications. Isolated cortical damage following irradiation represents an extremely rare delayed therapeutic complication, described only twice in the medical literature. We report this rare delayed complication in a patient following treatment of a right frontal anaplastic oligodendroglioma.

Stakes of a cooperation: preliminary inquiry led with the C.L.I. and I.R.S.N

International Nuclear Information System (INIS)

Gadbois, S.; Vaillant, L.

2004-01-01

The national association of local commissions of information (A.N.C.L.I.) and the institute of radiation protection and nuclear safety (I.R.S.N.) agreed to define experimental actions for year 2004 within the framework of their protocol concerning the scientific and technical support brought by the institute to the local commissions of information (C.L.I) in this perspective, both organizations wished beforehand to realize an inquiry on the expectations of the C.L.I. and the I.R.S.N. in follow-up of release and surveillance of the nuclear installations environment. The present document reports objectives and methodology of the inquiry, results obtained notably by underlining the identified problems and the actions suggested to remedy it. (N.C.)

AP1000R design robustness against extreme external events - Seismic, flooding, and aircraft crash

International Nuclear Information System (INIS)

Pfister, A.; Goossen, C.; Coogler, K.; Gorgemans, J.

2012-01-01

Both the International Atomic Energy Agency (IAEA) and the U.S. Nuclear Regulatory Commission (NRC) require existing and new nuclear power plants to conduct plant assessments to demonstrate the unit's ability to withstand external hazards. The events that occurred at the Fukushima-Dai-ichi nuclear power station demonstrated the importance of designing a nuclear power plant with the ability to protect the plant against extreme external hazards. The innovative design of the AP1000 R nuclear power plant provides unparalleled protection against catastrophic external events which can lead to extensive infrastructure damage and place the plant in an extended abnormal situation. The AP1000 plant is an 1100-MWe pressurized water reactor with passive safety features and extensive plant simplifications that enhance construction, operation, maintenance and safety. The plant's compact safety related footprint and protection provided by its robust nuclear island structures prevent significant damage to systems, structures, and components required to safely shutdown the plant and maintain core and spent fuel pool cooling and containment integrity following extreme external events. The AP1000 nuclear power plant has been extensively analyzed and reviewed to demonstrate that it's nuclear island design and plant layout provide protection against both design basis and extreme beyond design basis external hazards such as extreme seismic events, external flooding that exceeds the maximum probable flood limit, and malicious aircraft impact. The AP1000 nuclear power plant uses fail safe passive features to mitigate design basis accidents. The passive safety systems are designed to function without safety-grade support systems (such as AC power, component cooling water, service water, compressed air or HVAC). The plant has been designed to protect systems, structures, and components critical to placing the reactor in a safe shutdown condition within the steel containment vessel which is

Seasonal Climate Extremes : Mechanism, Predictability and Responses to Global Warming

NARCIS (Netherlands)

Shongwe, M.E.

2010-01-01

Climate extremes are rarely occurring natural phenomena in the climate system. They often pose one of the greatest environmental threats to human and natural systems. Statistical methods are commonly used to investigate characteristics of climate extremes. The fitted statistical properties are often

Le projet français P.I.V.E.R.T.

Directory of Open Access Journals (Sweden)

Rous Jean-François

2012-11-01

Full Text Available P.I.V.E.R.T. is an ambitious project of development of the 3rd generation biorefinery by 2020. Conceived around a technological complex with strict environmental criteria (aiming at obtaining a label HQE, P.I.V.E.R.T. federates all the national and main roads lifeblood, of the sector (some international partnerships are also under development. The major objectives of the P.I.V.E.R.T. project are: a valorization of oilseeds, proteins and lignocellulosic plant in its entirety (approach ‘‘entire plants’’ ; an operation in closed circuit on the level of water and energy exchanges, the platform providing for its own needs, in a logic of industrial ecology ; collection and valorization of a significant part of the CO2 produced by the activities of the refinery. Two strategies will be developed jointly: on one hand the development of ‘‘platform’’ molecules entering the traditional circuits of chemistry, on the current markets with the renewable character, in addition, the development of new molecules having new properties, thus giving access to new markets. Thanks to the research and development realized by researchers dedicated to P.I.V.E.R.T., the industrial partners will have access to a capable structure to develop, and to test demonstrators preceding future industrial production units. Certain technological bricks could be tested in a large scale industrial platform dedicated to operational integration of innovations. The development of programming technologies of refineries will give to P.I.V.E.R.T. the means to develop new innovative processes and will give to the industrials the possibility of modeling their future production units.

Reinfection And Bilateral Infection : Two Rare Manifestations Of Sporotrichosis

Directory of Open Access Journals (Sweden)

Maiti P. K

1999-01-01

Full Text Available The localization of sporotrichosis is determined by the site of dermal injury by means of which the infective spores are introduced into subcutanceous tissue, but the reports of reinfection or bilateral infection are extremely rare. Although the probability of such occurrence is high in endemic areas, the rare incidence may be due to acquired host defense, a subject of much speculation. Two such rare cases are presented and some reports of cross infections of the disease are reviewed.

Cronkhite-Canada Syndrome (CCS)-A Rare Case Report.

Science.gov (United States)

Chakrabarti, Subrata

2015-03-01

Cronkhite-Canada syndrome (CCS) is an extremely rare non-inherited condition characterized by gastrointestinal hamartomatous polyposis, alopecia, onychodystrophy, hyperpigmentation, weight loss and diarrhoea. The aetiology is probably autoimmune and diagnosis is based on history, physical examination, endoscopic findings of gastrointestinal polyposis, and histology. The disease is very rare; approximately 450 cases of CCS have been reported worldwide. The author reports a case of CCS in an elderly Indian male.

Microtropins A-I: 6'-O-(2″S,3″R)-2″-ethyl-2″,3″-dihydroxybutyrates of aliphatic alcohol β-D-glucopyranosides from the branches of Microtropis japonica.

Science.gov (United States)

Uemura, Yuka; Sugimoto, Sachiko; Matsunami, Katsuyoshi; Otsuka, Hideaki; Takeda, Yoshio; Kawahata, Masatoshi; Yamaguchi, Kentaro

2013-03-01

From the branches of Microtropis japonica (Celastraceae), nine aliphatic glucosides, named microtropins A-I, were isolated. The 6-position of glucose was esterified with (2S,3R)-2-ethyl-2,3-dihydroxybutyric acid. Microtropins A-D contained a rare natured product nitrile functional group in their aglycones. The absolute structures of the (2S,3R)-2-ethyl-2,3-dihydroxybutyric acid moiety and aglycone of microtropin A were determined by an X-ray crystallographic method. Copyright © 2012 Elsevier Ltd. All rights reserved.

Long-Term Climate Trends and Extreme Events in Northern Fennoscandia (1914–2013

Directory of Open Access Journals (Sweden)

Sonja Kivinen

2017-02-01

Full Text Available We studied climate trends and the occurrence of rare and extreme temperature and precipitation events in northern Fennoscandia in 1914–2013. Weather data were derived from nine observation stations located in Finland, Norway, Sweden and Russia. The results showed that spring and autumn temperatures and to a lesser extent summer temperatures increased significantly in the study region, the observed changes being the greatest for daily minimum temperatures. The number of frost days declined both in spring and autumn. Rarely cold winter, spring, summer and autumn seasons had a low occurrence and rarely warm spring and autumn seasons a high occurrence during the last 20-year interval (1994–2013, compared to the other 20-year intervals. That period was also characterized by a low number of days with extremely low temperature in all seasons (4–9% of all extremely cold days and a high number of April and October days with extremely high temperature (36–42% of all extremely warm days. A tendency of exceptionally high daily precipitation sums to grow even higher towards the end of the study period was also observed. To summarize, the results indicate a shortening of the cold season in northern Fennoscandia. Furthermore, the results suggest significant declines in extremely cold climate events in all seasons and increases in extremely warm climate events particularly in spring and autumn seasons.

Nodules on the Hair: A Rare Case of Mixed Piedra

OpenAIRE

Khatu, Swapna S; Poojary, Shital Amin; Nagpur, Niranjan G

2013-01-01

Piedra is a superficial fungal infection of the hair shaft characterized by nodules along the hair shaft. Black piedra affects the scalp hair more frequently than white piedra. Occurrence of both types of piedra simultaneously in a patient is extremely rare. We describe here a rare case of mixed piedra of scalp hair.

Nodules on the hair: a rare case of mixed piedra.

Science.gov (United States)

Khatu, Swapna S; Poojary, Shital Amin; Nagpur, Niranjan G

2013-10-01

Piedra is a superficial fungal infection of the hair shaft characterized by nodules along the hair shaft. Black piedra affects the scalp hair more frequently than white piedra. Occurrence of both types of piedra simultaneously in a patient is extremely rare. We describe here a rare case of mixed piedra of scalp hair.

Quantifying extreme risks in stock markets: A case of former Yugoslavian states

Directory of Open Access Journals (Sweden)

Saša Žiković

2008-06-01

Full Text Available One of the reasons why investors were not prepared for heavy losses in the stock markets that occurred after the beginning of sub prime mortgage crisis in the US lies in the curious fact that many practitioners were led to believe that there are so many independent agents participating in the stock markets that surely they must act according to Central limit theorem i.e. according to Gaussian distribution. As it turns out the paradigm of normality has let us down once again and reputation of VaR based risk measurement is seriously damaged. An alternative measure that looks very strong at these dire times and quantifi es the losses that might be encountered in the tail is the conditional VaR (CVaR. While VaR represents a loss one expects at a determined confi dence level for a given holding period, CVaR is the loss one expects, provided that the loss is equal to or greater than VaR. In this paper the testing of CVaR models is performed on stock indexes from Slovenia, Croatia, Bosnia and Herzegovina, Serbia, Montenegro and Macedonia. Error statistics show that CVaR models are quite successful at capturing extreme losses that occurred in these markets, especially models based on Generalized extreme value distribution and a proposed Hybrid historical simulation CVaR model.

A very bright SAR arc: implications for extreme magnetosphere-ionosphere coupling

Directory of Open Access Journals (Sweden)

J. Baumgardner

2008-01-01

Full Text Available In contrast to the polar aurora visible during geomagnetic storms, stable auroral red (SAR arcs offer a sub-visual manifestation of direct magnetosphere-ionosphere (M-I coupling at midlatitudes. The SAR arc emission at 6300 Å is driven by field-aligned magnetospheric energy transport from ring current/plasmapause locations into the ionosphere-thermosphere system. The first SAR arc was observed at the dawn of the space age (1956, and the typical brightness levels and occurrence patterns obtained from subsequent decades of observations appear to be consistent with the downward heat conduction theory, i.e., heated ambient F-layer electrons excite oxygen atoms to produce a spectrally pure emission. On very rare occasions, a SAR arc has been reported to be at brightness levels visible to the naked eye. Here we report on the first case of a very bright SAR arc (~13 kilo-Rayleighs observed by four diagnostic systems that sampled various aspects of the sub-auroral domain near Millstone Hill, MA, on the night of 29 October 1991: an imaging spectrograph, an all-sky camera, an incoherent scatter radar (ISR, and a DMSP satellite. Simulations of emission using the ISR and DMSP data with the MSIS neutral atmosphere succeed in reproducing the brightness levels observed. This provides a robust confirmation of M-I coupling theory in its most extreme aeronomic form within the innermost magnetosphere (<i>L>~2 during a rare superstorm event. The unusually high brightness value appears to be due to the rare occurrence of the heating of dense ionospheric plasma just equatorward of the trough/plasmapause location, in contrast to the more typical heating of the less dense F-layer within the trough.

Rare metal and rare earth pegmatites of Western India

International Nuclear Information System (INIS)

Maithani, P.B.; Nagar, R.K.

1999-01-01

Rajasthan Mica Belt in western India is one of the three major mica-producing Proterozoic pegmatite belts of India, the others being in Bihar and Andhra Pradesh. The pegmatites of these mica belts, in general, are associated with the rare metal (RM) and rare earth element (REE)-bearing minerals like columbite-tantalite, beryl, lepidolite and other multiple oxides. RM-REE pegmatites of Gujarat are devoid of commercially workable mica. These pegmatites are geologically characterised in this paper, based on their association with granite plutons geochemistry, and RM and REE potential. In addition to RM and RE-bearing pegmatites, granites of the Umedpur area, Gujarat also show anomalous concentration (0.97 wt%) of rare metals (6431 ppm Nb, 1266 ppm Ta, 454 ppm Sn, 173 ppm W), (1098 ppm Ce 1.36% Y 2 O 3 ) rare earths, and uranium (0.40% eU 3 O 8 ). Eluvial concentrations in the soil and panned concentrate (0.04-0.28 wt%) analysed up to 7.4%Nb 2 O 5 , 836 ppm Ta, and 1.31% Y. Discrete columbite-tantalite and betafite have been identified in these concentrates in addition to other minerals like zircon, rutile, sphene and xenotime. This area with discrete RM R EE mineral phases could be significant as a non-pegmatite source for rare metal and rare earths. (author)

Synovial Sarcoma-A Rare Tumor of the Larynx

Directory of Open Access Journals (Sweden)

Ghodrat Mohammadi

2016-05-01

Full Text Available Introduction: Malignant mesenchymal tumors of the larynx are rare. One type of malignant mesenchymal tumor is synovial sarcoma with unknown histogenesis, which occurs predominantly in the lower extremities of young adults. The head and neck region is a relatively rare location. There are few cases of malignant mesenchymal tumors with laryngeal localization in literature.  Case Report: In this report, a new case in a 23-year-old man, which was referred with increasing hoarseness for eight months, and dysphagia, odynophagia, and dyspnea since nearly one year ago, is reported. Indirect laryngoscopy revealed a laryngeal submucosal mass. The patient was operated and the histopathological diagnosis of synovial sarcoma was confirmed by IHC (Immunohistochemisry.  Conclusion:  Synovial sarcoma occurs predominantly in the lower extremities of young adults. Because very few cases of laryngeal synovial sarcoma are reported, every new case will bring some new information about diagnosis and therapy. It is of utmost importance to get to know new aspects and therapeutical modalities of this rare tumor.

Lipofibromatous Hamartoma of the Plantar Nerve An Extremely Rare Localization.

Science.gov (United States)

Mert, Murat; Hacısalihoglu, Payam

2018-03-01

Lipofibromatous hamartoma (LFH) is a rare, benign, tumor-like soft-tissue lesion that affects the peripheral nerves and forms a palpable neurogenic mass. Lipofibromatous hamartoma is associated with pain and sensory and/or motor deficits in the area of innervation of the affected nerve. This report describes a rare case of LFH of the plantar nerve. A 48-year-old woman presented to our outpatient orthopedic clinic with pain and a burning sensation on her left foot. The patient had a history of Morton's neuroma and had undergone a tarsal tunnel operation 2 years earlier at another center. None of her symptoms was alleviated by two previous operations. Magnetic resonance imaging with contrast revealed tenosynovitis of the flexor hallucis longus tendon and signal changes at deep tissue planes of the foot at the levels of the second and third toes, on the dorsal site and subcutaneous soft-tissue planes, suggesting edema and Morton's neuroma. The lesion was excised under spinal anesthesia, and histopathologic examination of the specimen revealed a diagnosis of LFH. The patient was discharged without any symptoms and her foot was normal at 8-month outpatient follow-up, with no indications of postoperative complications and/or recurrence.

”Øvelse gør mester” i Næstved Kommune

DEFF Research Database (Denmark)

Siren, Anu; Brünner, Rikke Nøhr; Jørgensen, Rune Christian Holger

I januar 2012 iværksatte Næstved Kommune rehabiliteringsprojektet ”Øvelse gør mester” på alle kommunens plejecentre. Målet var at gøre beboerne mere selvhjulpne og derigennem øge deres livskvalitet. Denne rapport er en evaluering af projektet. ”Øvelse gør mester” består af individuelt tilrettelagte...

Acquired ventricular septal defect: A rare sequel of blunt chest ...

African Journals Online (AJOL)

Ventricular septal defect (VSD) is the most common congenital cardiac lesion encountered worldwide. Only very rarely is it acquired, and causation through blunt injury in a child is extremely rare. A previously healthy 7‑year‑old boy suffered blunt chest trauma while at play. He presented 11 days later with features of acute ...

Rare earth materials research in European Community R and D programmes

International Nuclear Information System (INIS)

Gavigan, J.P.

1992-01-01

The level of involvement of EC research programmes in rare earth materials research is quite high. A total of 65 projects have been identified representing an involvement of 283 partners from all over Europe. This corresponds to a budget a 63.3 MECU (76MDollars) of which the EC contributes 40.7 MECU (49MDollars). In this paper, the various research activities will be discussed under the main themes of rare earth permanent magnets, high Tc superconductors, optical and other materials, with specific reference to the three main programmes involved, BRITE/EURAM, SCIENCE and ESPRIT. Two other programmes currently involved in rare earth research are RAW MATERIALS and JOULE. (orig.)

Properties of Extreme Point Rainfall I

DEFF Research Database (Denmark)

Harremoës, Poul; Mikkelsen, Peter Steen

1995-01-01

Extreme rainfall has been recorded by the larger municipalities in Denmark since 1933. National intensity-duration-frequency curves were produced on this basis for engineering application in the whole of Denmark. In 1979, on the initiative of The Danish Water Pollution Control Committee under...

Sharing Rare Attitudes Attracts.

Science.gov (United States)

Alves, Hans

2018-04-01

People like others who share their attitudes. Online dating platforms as well as other social media platforms regularly rely on the social bonding power of their users' shared attitudes. However, little is known about moderating variables. In the present work, I argue that sharing rare compared with sharing common attitudes should evoke stronger interpersonal attraction among people. In five studies, I tested this prediction for the case of shared interests from different domains. I found converging evidence that people's rare compared with their common interests are especially potent to elicit interpersonal attraction. I discuss the current framework's theoretical implications for impression formation and impression management as well as its practical implications for improving online dating services.

Scapulothoracic Dissociation: A Rare Variant: A Case Report

Directory of Open Access Journals (Sweden)

Rajat Jangir

2014-07-01

Full Text Available Scapulothoracic dissociation is a rare injury involving separation of scapula from the thorax along with the upper extremity. Majority of the patients have concomitant neurovascular injury and the prognosis is uniformly poor in such cases. We present a case of scapulothoracic dissociation with comminuted fracture of scapula and acromioclavicular joint disruption without neurovascular deficit. There were associated avulsion fractures of the spinous processes of vertebrae (T3-T5. Such presentation is rare in an already rare scapulothoracic dissociation injury. A discussion regarding the probable mechanism of injury, management and prognosis is presented.

Complex formation constant and hydration number change of aqua-rare earth ions

International Nuclear Information System (INIS)

Kanno, H.

1998-01-01

Full text: It is now well established that the inner-sphere hydration number of aqua-rare earth ions changes from nine to eight in the middle of the rare earth series. This hydration number change greatly affects the complex formation of rare earth ions as we observe irregular variations in most series behaviours of the complex formation constant (K) in aqueous solution systems when K being plotted against 1/r or r (r is ionic radius of rare earth ion). Furthermore, it shows very anomalous concentration dependence in the sense that nona-aqua Ln 3+ ion increases in number with increase in salt concentration in aqueous rare earth salt solution (salt chloride, perchlorate). In this report, a theoretical derivation of the formation constant (K) for the inner-sphere complex formation of rare earth ions with a monodentate ligand was made by taking account of both the hydration number change in the middle of the series and its anomalous salt concentration dependence. The series behaviour of the formation constant against 1/r (or r) is successfully explained with using the empirical finding that K varies almost linearly with 1/r (or r) in the region where only one hydration number dominates. This success is also taken as evidence that the anomalous salt concentration dependence of the hydration number change is caused by the outer-sphere complex formation of rare earth ions with the condition that nona-aqua rare earth ions form outer-sphere complexes more easily than octa-aqua ions

Tail-like Congenital Duplication of Lower Extremity (Extra Leg or ...

African Journals Online (AJOL)

2018-01-01

Jan 1, 2018 ... ABSTRACT. BACKGROUND: Congenital duplication of lower extremity, either complete or incomplete is extremely rare. Only 26 cases had been reported till 2010, of which only 5 cases had feature of complete duplication. Theories have been proposed that the cause of this abnormality includes maternal ...

Rare case of gastrointestinal stromal tumor of the anal canal

Directory of Open Access Journals (Sweden)

Madhu Kumar

2013-01-01

Full Text Available Gastrointestinal stromal tumor (GIST is a rare mesenchymal neoplasm of the gastrointestinal tract. GIST of anal canal is very rare representing only 3% of all anorectal mesenchymal tumors. We report an extremely rare case of GIST of the anal canal in 60-years-old man with history of irregular bowel habits with dark colored stool mixed with blood and constipation from 6 month. Diagnosis was made on the basis of histomorphological and immunohistochemical examination.

Non-extremal D-instantons

NARCIS (Netherlands)

Bergshoeff, E; Collinucci, A; Gran, U; Roest, D; Vandoren, S

2004-01-01

We construct the most general non-extremal deformation of the D-instanton solution with maximal rotational symmetry. The general non-supersymmetric solution carries electric charges of the SL(2,R) symmetry, which correspond to each of the three conjugacy classes of SL (2, R). Our calculations

Non-extremal D-instantons

NARCIS (Netherlands)

Bergshoeff, E.; Collinucci, A.; Gran, U.; Roest, D.; Vandoren, S.

2004-01-01

We construct the most general non-extremal deformation of the D-instanton solution with maximal rotational symmetry. The general non-supersymmetric solution carries electric charges of the SL(2,R) symmetry, which correspond to each of the three conjugacy classes of SL(2,R). Our calculations

Organizational Learning in Rare Events

DEFF Research Database (Denmark)

Andersen, Kristina Vaarst; Tyler, Beverly; Beukel, Karin

When organizations encounter rare events they often find it challenging to extract learning from the experience. We analyze opportunities for organizational learning in one such rare event, namely Intellectual Property (IP) litigation, i.e., when organizations take disputes regarding their intell......When organizations encounter rare events they often find it challenging to extract learning from the experience. We analyze opportunities for organizational learning in one such rare event, namely Intellectual Property (IP) litigation, i.e., when organizations take disputes regarding...... the organization little discretion to utilize any learning from past litigation success. Thus, learning appears be to most beneficial in infringement cases. Based on statistical analysis of 10,211 litigation court cases in China, we find support for our hypotheses. Our findings suggest that organizations can learn...

Raman scattering of rare earth hexaborides

International Nuclear Information System (INIS)

Ogita, Norio; Hasegawa, Takumi; Udagawa, Masayuki; Iga, Fumitoshi; Kunii, Satoru

2009-01-01

Raman scattering spectra were measured for the rare-earth hexaborides RB 6 (R = Ce, Gd, or Dy). All Raman-active phonons due to B 6 vibrations were observed in the range 600 - 1400 cm -1 . Anomalous peaks were detected below 200 cm -1 , which correspond to vibrations of rare-earth ion excited by second-order Raman scattering process. The intensity and energy of the rare-earth mode decrease with decreasing temperature. This suggests that the rare-earth ion vibrates in a shallow and anharmonic potential due to the boron cage. Using the reported values of mean square displacement of rare-earth ion, we estimated the anharmonic contribution for the rare-earth vibrations.

Leiomyoma of Testis –Rare Benign Mimicker of Testicular Malignancy

Directory of Open Access Journals (Sweden)

Asif Baliyan

2017-10-01

Full Text Available Leiomyomas are benign tumours that originate from any organ containing smooth muscles. The testis is an extremely rare site. We report a case of testicular leiomyoma in a 50-year-old. Testis-associated leiomyomas are a benign and rare disease presenting as a painless, slowly-growing mass. Only histological examination with immunohistochemistry can validate the diagnosis.

Extraction of rare earths and hydrochloric acid by trialkylphosphine oxide

International Nuclear Information System (INIS)

Mikhajlichenko, A.I.; Karmannikov, V.P.; Klimenko, M.A.; Fedulova, T.V.

1983-01-01

Extraction of rare earth chlorides and hydrochloric acid by trialkylphosphine oxide with different radicals (POR) (RR' 2 PO-POR, where RR'=alkyl of a normal structure, containing 7 to 9 carbon atoms, R=isoamyl) has been studied. Distribution of lanthanum-, neodymium-, lutetium- and yttrium chlorides during extraction with 1.28 mol/l POR solution in white spirit is investigated in the salt concentration range in the equilibrium aqueous phase from 0 to 2.8 mol/l. Lanthanide distribution coefficients increase with an increase in the order number of elements, with the separation coefficients of two extreme members of the series (Lu and La) for chlorides and nitrates constituting 100 and 80, respectively microquantities of Ln against the background of macroquantities of La is 2.6 mol/l. According to the results of measurements of viscosity, electric conductivity and water content in the extracts a conclusion is made on the state of salt in the organic phase. In the systems POR-LnCl 3 -HCl-H 2 O the hydrochloric acid extraction increases with an increase in the rare earth chloride concentration and order number of the element

A novel albumin gene mutation (R222I) in familial dysalbuminemic hyperthyroxinemia.

Science.gov (United States)

Schoenmakers, Nadia; Moran, Carla; Campi, Irene; Agostini, Maura; Bacon, Olivia; Rajanayagam, Odelia; Schwabe, John; Bradbury, Sonia; Barrett, Timothy; Geoghegan, Frank; Druce, Maralyn; Beck-Peccoz, Paolo; O'Toole, Angela; Clark, Penelope; Bignell, Michelle; Lyons, Greta; Halsall, David; Gurnell, Mark; Chatterjee, Krishna

2014-07-01

Familial dysalbuminemic hyperthyroxinemia, characterized by abnormal circulating albumin with increased T4 affinity, causes artefactual elevation of free T4 concentrations in euthyroid individuals. Four unrelated index cases with discordant thyroid function tests in different assay platforms were investigated. Laboratory biochemical assessment, radiolabeled T4 binding studies, and ALB sequencing were undertaken. (125)I-T4 binding to both serum and albumin in affected individuals was markedly increased, comparable with known familial dysalbuminemic hyperthyroxinemia cases. Sequencing showed heterozygosity for a novel ALB mutation (arginine to isoleucine at codon 222, R222I) in all four cases and segregation of the genetic defect with abnormal biochemical phenotype in one family. Molecular modeling indicates that arginine 222 is located within a high-affinity T4 binding site in albumin, with substitution by isoleucine, which has a smaller side chain predicted to reduce steric hindrance, thereby facilitating T4 and rT3 binding. When tested in current immunoassays, serum free T4 values from R222I heterozygotes were more measurably abnormal in one-step vs two-step assay architectures. Total rT3 measurements were also abnormally elevated. A novel mutation (R222I) in the ALB gene mediates dominantly inherited dysalbuminemic hyperthyroxinemia. Susceptibility of current free T4 immunoassays to interference by this mutant albumin suggests likely future identification of individuals with this variant binding protein.

Aktør-netværksteori i arbejdslivsforskningen

DEFF Research Database (Denmark)

2012-01-01

for Tidsskrift for Arbejdsliv at stille skarpt på, hvorledes teknologi kan forstås og udforskes, og her står nyere teoridannelser som STS (Science- and Technology Studies) og ANT (Actor-Network Theory) centralt. Dette temanummer af tidsskriftet har derfor disse teorier og deres anvendelse i studier af arbejdsliv...

Two rare cases of laryngeal intralymphatic histiocytosis

DEFF Research Database (Denmark)

Reznitsky, Martin; Daugaard, Søren; Charabi, Birgitte Wittenborg

2016-01-01

We report two rare cases of intralymphatic histiocytosis causing, respectively, recurrent and persistent episodes of upper airway swelling and breathing difficulties. Case 1 was a 39-year-old man who was referred with recurrent upper airway swelling causing difficulty in breathing. A direct....... Extensive investigations were performed but discovered no abnormal findings. He received CO2 laser treatment twice and the swelling decreased. Intralymphatic histiocytosis is extremely rare in upper airway pathology. It is an important differential diagnosis in patients with recurrent and chronic laryngeal...

Xanthogranulomatous Prostatitis, a Rare Prostatic Entity

Directory of Open Access Journals (Sweden)

Alejandro Noyola

2017-01-01

Full Text Available There are several benign prostatic pathologies that can clinically mimic a prostate adenocarcinoma. Xanthogranulomatous prostatitis is a benign inflammatory condition of the prostate and a rare entity. A 47-year old male, with 3 years of lower urinary tract symptoms, with a palpable hypogastric tumor, digital rectal examination: solid prostate, of approximately 60 g. Initial PSA was 0.90 ng/mL. He underwent surgical excision of the lower abdominal nodule and prostatectomy. Histopathology showed xanthogranulomatous prostatitis, without malignancy. Xanthogranulomatous prostatitis is an extremely rare entity that can simulate prostate adenocarcinoma, therefore having a correct histopathological diagnosis is essential.

A rare presentation of hydatid cyst

International Nuclear Information System (INIS)

Sabir, N.; Yildirim, B.; Alatas, E.; Cetin, B.

2005-01-01

Hydatid disease, although known to occur in most body areas, is extremely rare in the female reproductive system. There are different modes of presentation for the disease; however, we report and discuss a case presented with cystic vesicles passing through the vagina, which is considered as a rare presentation for secondary involvement of the uterus and both ovaries. We confirmed diagnosis with radiological examinations and serological tests. We operated on the patient, and studied the excised cysts microscopically. The gynecologist should be aware of hydatid cyst when vaginally passing a grape like vesicle is presented by the patient. (author)

CISG DEL II og Værneting i UfR 1998.1092 ØLK

DEFF Research Database (Denmark)

Lookofsky, Joseph

1998-01-01

I UfR 1998.1092 ØLK anvender en dansk domstol reglerne om købsaftalers indgåelse i CISG-konventionens del II. Det sker for at afgøre, om der er værneting i Danmark efter EF-domskonventionens artikel 5, nr. 1, når sagsøgte bestrider, at der er indgået en købsaftale. Sagen sætter fokus på behovet...

Clinical significance of a proposed lymphoscintigrpahic functional grade system in patients with extremity lymphedema of stage i

International Nuclear Information System (INIS)

Choi, Joan Young; Hwang, Ji Hye; Kim, Dong Ik; Cho, Young Seok; Lee, Su Jin; Choi, Yong; Choe, Yeam Seong; Lee, Kyung Han; Kim, Byung Tae

2005-01-01

We proposed a new lymphoscintigrpahic functional grade (LGr) system in extremity lymphedema, and investigated the association between the LGr and a long-term response to physical therapy in patients with extremity lymphedema of stage I. The subjects were 20 patients with unilateral extremity lymphedema of stage I, who underwent pre-treatment extremity lymphoscintigraphy using Tc-99m antimony sulfur colloid, and were treated by complex decongestive physical therapy (CDPT). A proposed lymphoscintigrpahic functional grade system consisted of LGr 0 to LGr 4 according to the ilioinguinal nodal uptake, amount of dermal backflow, and uptake pattern of main and collateral lymphatics : LGr 0 = normal, LGr 1 = decreased lymphatic function without dermal backflow, LGr 2 = decreased lymphatic function with dermal backflow, LGr 3 = non - visualization of main lymphatics with dermal backflow, and LGr 4 = no significant lymphatic transport from injection site. LGr 2 was divided into 2A and 2B based on the amount of dermal backflow. A physician who is a lymphedema specialist determined the long-term outcome to CDPT with normalized response (NR), good response (GR) and poor response (PR) based on the change of edema volume reduction, skin status and occurrence of dermatolymphangioadenitis after the clinical follow-up for more than 1 year. Therapeutic responses were NR in 2 patients. GR in 9 patients and PR in 9 patients. Baseline LGrs were 1 in 7 patients, 2A in 4 patients, 2B in 5 patients, 3 in 2 patients, and 4 in 2 patients. There was a significant relationship between therapeutic response and LGr (p=0.003). In other words, 10 of 11 patients (91%) with LGr 1 or 2A showed NR. or GR. On the contrary, 8 of 9 patients (89%) with LGr 2B, 3 or 4 showed PR. Patients with unilateral extremity lymphedema of stage I had different lymphoscintigrpahic functional grades. This grade system may be useful to predict the response to physical therapy in such patients

Clinical significance of a proposed lymphoscintigrpahic functional grade system in patients with extremity lymphedema of stage i

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Choi, Joan Young; Hwang, Ji Hye; Kim, Dong Ik; Cho, Young Seok; Lee, Su Jin; Choi, Yong; Choe, Yeam Seong; Lee, Kyung Han; Kim, Byung Tae [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

2005-07-01

We proposed a new lymphoscintigrpahic functional grade (LGr) system in extremity lymphedema, and investigated the association between the LGr and a long-term response to physical therapy in patients with extremity lymphedema of stage I. The subjects were 20 patients with unilateral extremity lymphedema of stage I, who underwent pre-treatment extremity lymphoscintigraphy using Tc-99m antimony sulfur colloid, and were treated by complex decongestive physical therapy (CDPT). A proposed lymphoscintigrpahic functional grade system consisted of LGr 0 to LGr 4 according to the ilioinguinal nodal uptake, amount of dermal backflow, and uptake pattern of main and collateral lymphatics : LGr 0 = normal, LGr 1 = decreased lymphatic function without dermal backflow, LGr 2 = decreased lymphatic function with dermal backflow, LGr 3 = non - visualization of main lymphatics with dermal backflow, and LGr 4 = no significant lymphatic transport from injection site. LGr 2 was divided into 2A and 2B based on the amount of dermal backflow. A physician who is a lymphedema specialist determined the long-term outcome to CDPT with normalized response (NR), good response (GR) and poor response (PR) based on the change of edema volume reduction, skin status and occurrence of dermatolymphangioadenitis after the clinical follow-up for more than 1 year. Therapeutic responses were NR in 2 patients. GR in 9 patients and PR in 9 patients. Baseline LGrs were 1 in 7 patients, 2A in 4 patients, 2B in 5 patients, 3 in 2 patients, and 4 in 2 patients. There was a significant relationship between therapeutic response and LGr (p=0.003). In other words, 10 of 11 patients (91%) with LGr 1 or 2A showed NR. or GR. On the contrary, 8 of 9 patients (89%) with LGr 2B, 3 or 4 showed PR. Patients with unilateral extremity lymphedema of stage I had different lymphoscintigrpahic functional grades. This grade system may be useful to predict the response to physical therapy in such patients.

Chromosome-wise dissection of the genome of the extremely big mouse line DU6i

NARCIS (Netherlands)

M.R. Bevova (Marianna); Y.S. Aulchenko (Yurii); G. Aksu (Guzide); U. Renne (Ulla); K. Brockmann

2006-01-01

textabstractThe extreme high-body-weight-selected mouse line DU6i is a polygenic model for growth research, harboring many small-effect QTL. We dissected the genome of this line into 19 autosomes and the Y chromosome by the construction of a new panel of chromosome substitution strains (CSS). The

Extreme waves at Filyos, southern Black Sea

Directory of Open Access Journals (Sweden)

E. Bilyay

2011-03-01

Full Text Available A wave measurement project was carried out for a new port planned in Filyos, in the Western Black Sea region of Turkey. The measurement at a depth of 12.5 m lasted for a period of two years and 7949 records were obtained. During the analysis, it was noticed that there were 209 records in which <i>H/H>_s ratio was higher than 2.0. These higher waves in a record are called extreme waves in this study. Although the purpose of wave measurement is not to investigate extreme waves, it is believed that studying these unexpected waves could be interesting. Therefore, detailed statistical and spectral analyses on the extreme waves were done for the records. The analyses results show that the distribution of surface profiles of the records containing extreme waves deviates from Gaussian distribution with the negative skewness changing between –0.01 and –0.4 and with the high kurtosis in the range of 3.1–4.2. Although the probability of occurrence of the extreme waves is over-predicted by the Rayleigh distribution, a higher ratio of <i>H>_s/η_rms indicates that the wave height distribution can be represented by Rayleigh. The average value of the slope of the frequency spectrum at the high frequency range is proportional to <i>f>^–9 which is much steeper than the typical wind-wave frequency power law, <i>f>^{–4, –5}. The directional spreading is measured with the parameter <i>S>_max and it is in the range of 5–70 for the extreme wave records. The wave and current interaction was also investigated and it was found that in most cases, extreme waves occur when the wave and the current are almost aligned. Furthermore, it is observed that extreme waves appear within a group of high waves.