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Sample records for extremely complex due

  1. A rare form of extremely wide QRS complex due to reversed homologous electrical ventricular separation of acute heart failure.

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    Yan, Sujuan; Yu, Jianhua; Xia, Zhen; Zhu, Bo; Hu, Jinzhu; Li, Juxiang

    2017-06-29

    Electrical ventricular separation, as a special complete intraventricular block, denotes that ventricles be electrically separated into two or more parts caused by severe and wide damage of myocardium and conduction. Electrical ventricular separation can be divided into homologous and heterologous, homologous electrical ventricular separation is a rare phenomenon, literally the excitement of whole ventricle originate from supraventricle, on ECG, there are two different QRS waves which connect with an isoelectric line, one ST segment and T wave. We report a valve heart disease presented with complicated electrophysiological characteristics, which has reversed complex homologous electrical ventricular separation with second degree intraventricular block. © 2017 Wiley Periodicals, Inc.

  2. Extreme situations due to gender violence

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    Stela Meneghel

    2012-11-01

    Full Text Available This paper presents a synthesis of the third Critical Paths Seminar, held in Porto Alegre/Brazil in 2011, whose focus was extreme situations of gender violence. The extreme situations are human rights violations that include femicide or murder motivated by the situation of gender; LGBT murders, human rights violations of ethnic and racial minorities, sexual exploitation, violence to women in vulnerable situations and other violence caused by gender. The meeting objective was given space to share experiences, reflect critically and build strategies for facing violence and extreme situations resulting from gender systems.

  3. Intramolecular vibrational dynamical barrier due to extremely irrational couplings

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The intramolecular vibrational dynamics due to extremely irrational couplings is demonstrated by contrast to the resonance couplings, for the three-mode case of H2O as an example. The extremely irrational couplings are shown to impose such strong hindrance to intramolecular vibrational relaxation (IVR) that they act as barriers. They restrict the direct action/energy transfer between the two stretching modes, though they allow the transfer between a stretching and a bending modes. In contrast, the resonance is more mediated by the bending mode and leads to chaotic IVR. It is also shown that there is a region in the dynamical space in which resonance and extremely irrational couplings coexist.

  4. Stability of extremal metrics under complex deformations

    CERN Document Server

    Rollin, Yann; Tipler, Carl

    2011-01-01

    Let $(\\mathcal {X},\\Omega)$ be a closed polarized complex manifold, $g$ be an extremal metric on $\\mathcal X$ that represents the K\\"ahler class $\\Omega$, and $G$ be a compact connected subgroup of the isometry group $Isom(\\mathcal{X},g)$. Assume that the Futaki invariant relative to $G$ is nondegenerate at $g$. Consider a smooth family $(\\mathcal{M}\\to B)$ of polarized complex deformations of $(\\mathcal{X},\\Omega)\\simeq (\\mathcal{M}_0,\\Theta_0)$ provided with a holomorphic action of $G$. Then for every $t\\in B$ sufficiently small, there exists an $h^{1,1}(\\cX)$-dimensional family of extremal K\\"ahler metrics on $\\mathcal{M}_t$ whose K\\"ahler classes are arbitrarily close to $\\Theta_t$. We apply this deformation theory to analyze the Mukai-Umemura 3-fold and its complex deformations. In particular, we prove that there are certain complex deformation of the Mukai-Umemura 3-folds which have extremal metric of non constant scalar curvature with Kaehler class $c_1$.

  5. Constrained inflaton due to a complex scalar

    Energy Technology Data Exchange (ETDEWEB)

    Budhi, Romy H. S. [Physics Department, Gadjah Mada University,Yogyakarta 55281 (Indonesia); Institute for Theoretical Physics, Kanazawa University,Kanazawa 920-1192 (Japan); Kashiwase, Shoichi; Suematsu, Daijiro [Institute for Theoretical Physics, Kanazawa University,Kanazawa 920-1192 (Japan)

    2015-09-14

    We reexamine inflation due to a constrained inflaton in the model of a complex scalar. Inflaton evolves along a spiral-like valley of special scalar potential in the scalar field space just like single field inflation. Sub-Planckian inflaton can induce sufficient e-foldings because of a long slow-roll path. In a special limit, the scalar spectral index and the tensor-to-scalar ratio has equivalent expressions to the inflation with monomial potential φ{sup n}. The favorable values for them could be obtained by varying parameters in the potential. This model could be embedded in a certain radiative neutrino mass model.

  6. Extremely High Q-factor metamaterials due to Anapole Excitation

    CERN Document Server

    Basharin, Alexey A; Volsky, Nikita; Kafesaki, Maria; Economou, Eleftherios N

    2016-01-01

    We demonstrate that ideal anapole metamaterials have infinite Q-factor. We have designed and fabricated a metamaterial consisting of planar metamolecules which exhibit anapole behavior in the sense that the electric dipole radiation is almost cancelled by the toroidal dipole one, producing thus an extremely high Q-factor at the resonance frequency. The size of the system, at the mm range, and the parasitic magnetic quadrupole radiation are the factors limiting the size of the Q-factor. In spite of the very low radiation losses the local fields at the metamolecules are extremely high, of the order of higher than the external incoming field.

  7. Extremely high Q -factor metamaterials due to anapole excitation

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    Basharin, Alexey A.; Chuguevsky, Vitaly; Volsky, Nikita; Kafesaki, Maria; Economou, Eleftherios N.

    2017-01-01

    We have designed and fabricated a metamaterial consisting of planar metamolecules which exhibit unusual, almost perfect anapole behavior in the sense that the electric dipole radiation is almost canceled by the toroidal dipole one, producing thus an extremely high Q -factor at the resonance frequency. Thus we have demonstrated theoretically and experimentally that metamaterials approaching ideal anapole behavior have very high Q -factor. The size of the system, at the millimeter range, and the parasitic magnetic quadrupole radiation are the factors limiting the size of the Q -factor. In spite of the very low radiation losses the estimated local fields at the metamolecules are extremely high, of the order of 104 higher than the external incoming field.

  8. The Damage To The Armour Layer Due To Extreme Waves

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    Oztunali Ozbahceci, Berguzar; Ergin, Aysen; Takayama, Tomotsuka

    2010-05-01

    The sea waves are not regular but random and chaotic. In order to understand this randomness, it is common to make individual wave analysis in time domain or spectral analysis in frequency domain. Characteristic wave heights like Hmax, H%2,H1-10, H1-3, Hmean are obtained through individual wave analysis in time domain. These characteristic wave heights are important because they are used in the design of different type of coastal structures. It is common to use significant wave height, H1-3,for the design of rubble mound structures. Therefore, only spectrally derived or zero-crossing significant wave height is usually reported for the rubble mound breakwaters without any information on larger waves. However, even the values of H1-3are similar; some train of irregular waves may exhibit a large fluctuation of instantaneous wave energy, while another train may not show such a fluctuation (Goda, 1998). Moreover, freak or rogue wave, simply defined as the wave exceeding at least twice the significant wave height may also occur. Those larger waves were called as extreme waves in this study and the effect of extreme waves on the damage to the armour layer of rubble mound breakwaters was investigated by means of hydraulic model experiment. Rock armored rubble mound breakwater model with 1:1.5 slope was constructed in the wave channel of Hydraulics Laboratory of the Disaster Prevention Research Institute of Kyoto University, Japan. The model was consisted of a permeable core layer, a filter and armour layer with two stones thicknesses. Size of stones were same for both of the slopes as Dn50(armour)=0.034m, Dn50(filter)=0.021m and Dn50(core)=0.0148m for armour, filter and core layers, respectively. Time series which are approximately equal to 1000 waves, with similar significant wave height but different extreme wave height cases were generated. In order to generate necessary time series in the wave channel, they were firstly computed by numerically. For the numerical

  9. Automated assessment of upper extremity movement impairment due to stroke.

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    Erienne V Olesh

    Full Text Available Current diagnosis and treatment of movement impairment post-stroke is based on the subjective assessment of select movements by a trained clinical specialist. However, modern low-cost motion capture technology allows for the development of automated quantitative assessment of motor impairment. Such outcome measures are crucial for advancing post-stroke treatment methods. We sought to develop an automated method of measuring the quality of movement in clinically-relevant terms from low-cost motion capture. Unconstrained movements of upper extremity were performed by people with chronic hemiparesis and recorded by standard and low-cost motion capture systems. Quantitative scores derived from motion capture were compared to qualitative clinical scores produced by trained human raters. A strong linear relationship was found between qualitative scores and quantitative scores derived from both standard and low-cost motion capture. Performance of the automated scoring algorithm was matched by averaged qualitative scores of three human raters. We conclude that low-cost motion capture combined with an automated scoring algorithm is a feasible method to assess objectively upper-arm impairment post stroke. The application of this technology may not only reduce the cost of assessment of post-stroke movement impairment, but also promote the acceptance of objective impairment measures into routine medical practice.

  10. Automated assessment of upper extremity movement impairment due to stroke.

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    Olesh, Erienne V; Yakovenko, Sergiy; Gritsenko, Valeriya

    2014-01-01

    Current diagnosis and treatment of movement impairment post-stroke is based on the subjective assessment of select movements by a trained clinical specialist. However, modern low-cost motion capture technology allows for the development of automated quantitative assessment of motor impairment. Such outcome measures are crucial for advancing post-stroke treatment methods. We sought to develop an automated method of measuring the quality of movement in clinically-relevant terms from low-cost motion capture. Unconstrained movements of upper extremity were performed by people with chronic hemiparesis and recorded by standard and low-cost motion capture systems. Quantitative scores derived from motion capture were compared to qualitative clinical scores produced by trained human raters. A strong linear relationship was found between qualitative scores and quantitative scores derived from both standard and low-cost motion capture. Performance of the automated scoring algorithm was matched by averaged qualitative scores of three human raters. We conclude that low-cost motion capture combined with an automated scoring algorithm is a feasible method to assess objectively upper-arm impairment post stroke. The application of this technology may not only reduce the cost of assessment of post-stroke movement impairment, but also promote the acceptance of objective impairment measures into routine medical practice.

  11. Strong asymptotics for Lp extremal polynomials off a complex curve

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    Rabah Khaldi

    2004-01-01

    Full Text Available We study the asymptotic behavior of Lp(σ extremal polynomials with respect to a measure of the form σ=α+γ, where α is a measure concentrated on a rectifiable Jordan curve in the complex plane and γ is a discrete measure concentrated on an infinite number of mass points.

  12. Changes in weather extremes over East Asia due to global warming

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    Lee, Min-Hee; Ho, Chang-Hoi; Kim, Jinwon; Song, Chang-Geun

    2010-05-01

    The changes in weather extremes due to the global warming induced by the emissions of anthropogenic greenhouse gases have received growing attention in climate research community. In this study, the authors introduce new indices that assess changes in extreme vulnerability over East Asia for the periods of past 100 years and future 100 years. Observed temperatures and precipitation at 895 meteorological stations in Korea, China, and Japan have been analyzed for 1960s-2000s. In addition, we examined data from a global climate model simulation using the National Center for Atmospheric Research Community Climate System Model for 1900-2099. The observations show increasing trends in warm and dry extremes, and decreases in cold extremes, particularly in northern East Asia. A notable regional anomaly is the increase in wet extremes over the Korean Peninsula. The temperature extremes in the model simulations are similar to the observed features in the same region during the for the 20th and 21st century periods.

  13. 454 sequencing reveals extreme complexity of the class II Major Histocompatibility Complex in the collared flycatcher

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    Gustafsson Lars

    2010-12-01

    Full Text Available Abstract Background Because of their functional significance, the Major Histocompatibility Complex (MHC class I and II genes have been the subject of continuous interest in the fields of ecology, evolution and conservation. In some vertebrate groups MHC consists of multiple loci with similar alleles; therefore, the multiple loci must be genotyped simultaneously. In such complex systems, understanding of the evolutionary patterns and their causes has been limited due to challenges posed by genotyping. Results Here we used 454 amplicon sequencing to characterize MHC class IIB exon 2 variation in the collared flycatcher, an important organism in evolutionary and immuno-ecological studies. On the basis of over 152,000 sequencing reads we identified 194 putative alleles in 237 individuals. We found an extreme complexity of the MHC class IIB in the collared flycatchers, with our estimates pointing to the presence of at least nine expressed loci and a large, though difficult to estimate precisely, number of pseudogene loci. Many similar alleles occurred in the pseudogenes indicating either a series of recent duplications or extensive concerted evolution. The expressed alleles showed unambiguous signals of historical selection and the occurrence of apparent interlocus exchange of alleles. Placing the collared flycatcher's MHC sequences in the context of passerine diversity revealed transspecific MHC class II evolution within the Muscicapidae family. Conclusions 454 amplicon sequencing is an effective tool for advancing our understanding of the MHC class II structure and evolutionary patterns in Passeriformes. We found a highly dynamic pattern of evolution of MHC class IIB genes with strong signals of selection and pronounced sequence divergence in expressed genes, in contrast to the apparent sequence homogenization in pseudogenes. We show that next generation sequencing offers a universal, affordable method for the characterization and, in perspective

  14. Deterministic and Probabilistic Analysis of NPP Communication Bridge Resistance Due to Extreme Loads

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    Králik Juraj

    2014-12-01

    Full Text Available This paper presents the experiences from the deterministic and probability analysis of the reliability of communication bridge structure resistance due to extreme loads - wind and earthquake. On the example of the steel bridge between two NPP buildings is considered the efficiency of the bracing systems. The advantages and disadvantages of the deterministic and probabilistic analysis of the structure resistance are discussed. The advantages of the utilization the LHS method to analyze the safety and reliability of the structures is presented

  15. Quantifying the daily economic impact of extreme space weather due to failure in electricity transmission infrastructure

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    Oughton, Edward J.; Skelton, Andrew; Horne, Richard B.; Thomson, Alan W. P.; Gaunt, Charles T.

    2017-01-01

    Extreme space weather due to coronal mass ejections has the potential to cause considerable disruption to the global economy by damaging the transformers required to operate electricity transmission infrastructure. However, expert opinion is split between the potential outcome being one of a temporary regional blackout and of a more prolonged event. The temporary blackout scenario proposed by some is expected to last the length of the disturbance, with normal operations resuming after a couple of days. On the other hand, others have predicted widespread equipment damage with blackout scenarios lasting months. In this paper we explore the potential costs associated with failure in the electricity transmission infrastructure in the U.S. due to extreme space weather, focusing on daily economic loss. This provides insight into the direct and indirect economic consequences of how an extreme space weather event may affect domestic production, as well as other nations, via supply chain linkages. By exploring the sensitivity of the blackout zone, we show that on average the direct economic cost incurred from disruption to electricity represents only 49% of the total potential macroeconomic cost. Therefore, if indirect supply chain costs are not considered when undertaking cost-benefit analysis of space weather forecasting and mitigation investment, the total potential macroeconomic cost is not correctly represented. The paper contributes to our understanding of the economic impact of space weather, as well as making a number of key methodological contributions relevant for future work. Further economic impact assessment of this threat must consider multiday, multiregional events.

  16. Changes in extreme regional sea surface height due to an abrupt weakening of the Atlantic MOC

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    S.-E. Brunnabend

    2014-04-01

    Full Text Available As an extreme scenario of dynamical sea level changes, regional sea surface height (SSH changes that occur in the North Atlantic due to an abrupt weakening of the Atlantic Meridional Overturning Circulation (AMOC are simulated. Two versions of the same ocean-only model are used to study the effect of ocean model resolution on these SSH changes: a high-resolution (HR strongly eddying version and a low-resolution (LR version in which the effect of eddies are parameterized. The weakening of the AMOC is induced in both model versions by applying strong freshwater perturbations around Greenland. A rapid decrease of the AMOC in the HR version induces much shorter return times of several specific regional and coastal extremes in North Atlantic SSH than in the LR version. This effect is caused by a change in main eddy pathways associated with a change in separation latitude of the Gulf Stream.

  17. Genuine effectively biaxial left-handed metamaterials due to extreme coupling.

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    Menzel, Christoph; Alaee, Rasoul; Pshenay-Severin, Ekaterina; Helgert, Christian; Chipouline, Arkadi; Rockstuhl, Carsten; Pertsch, Thomas; Lederer, Falk

    2012-02-15

    Most left-handed metamaterials cannot be described by local effective permittivity or permeability tensors in the visible or near-infrared due to the mesoscopic size of the respective unit cells and the related strong spatial dispersion. We lift this problem and propose a metamaterial exhibiting artificial magnetism that does not suffer from this restriction. The artificial magnetism arises from the extreme coupling between both metallic films forming the unit cell. We show that its electromagnetic response can be properly described by biaxial local constitutive relations. A genuine biaxial left-handed fishnet metamaterial is suggested, which can be realized by atomic layer deposition to fabricate the nanoscaled spacing layers required for extreme coupling.

  18. Quantifying population exposure to airborne particulate matter during extreme events in California due to climate change

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    A. Mahmud

    2012-02-01

    Full Text Available The effect of climate change on population-weighted concentrations of particulate matter (PM during extreme events was studied using the Parallel Climate Model (PCM, the Weather Research and Forecasting (WRF model and the UCD/CIT 3-D photochemical air quality model. A "business as usual" (B06.44 global emissions scenario was dynamically downscaled for the entire state of California between the years 2000–2006 and 2047–2053. Air quality simulations were carried out for 1008 days in each of the present-day and future climate conditions using year-2000 emissions. Population-weighted concentrations of PM0.1, PM2.5, and PM10 total mass, components species, and primary source contributions were calculated for California and three air basins: the Sacramento Valley air basin (SV, the San Joaquin Valley air basin (SJV and the South Coast Air Basin (SoCAB. Results over annual-average periods were contrasted with extreme events.

    Climate change between 2000 vs. 2050 did not cause a statistically significant change in annual-average population-weighted PM2.5 mass concentrations within any major sub-region of California in the current study. Climate change did alter the annual-average composition of the airborne particles in the SoCAB, with notable reductions of elemental carbon (EC; −3% and organic carbon (OC; −3% due to increased annual-average wind speeds that diluted primary concentrations from gasoline combustion (−3% and food cooking (−4%. In contrast, climate change caused significant increases in population-weighted PM2.5 mass concentrations in central California during extreme events. The maximum 24-h average PM2.5 concentration experienced by an average person during a ten-year period in the SJV increased by 21% due to enhanced production of secondary particulate matter (manifested as NH4NO3. In general, climate change caused increased

  19. Extreme events in multilayer, interdependent complex networks and control

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    Chen, Yu-Zhong; Huang, Zi-Gang; Zhang, Hai-Feng; Eisenberg, Daniel; Seager, Thomas P.; Lai, Ying-Cheng

    2015-11-01

    We investigate the emergence of extreme events in interdependent networks. We introduce an inter-layer traffic resource competing mechanism to account for the limited capacity associated with distinct network layers. A striking finding is that, when the number of network layers and/or the overlap among the layers are increased, extreme events can emerge in a cascading manner on a global scale. Asymptotically, there are two stable absorption states: a state free of extreme events and a state of full of extreme events, and the transition between them is abrupt. Our results indicate that internal interactions in the multiplex system can yield qualitatively distinct phenomena associated with extreme events that do not occur for independent network layers. An implication is that, e.g., public resource competitions among different service providers can lead to a higher resource requirement than naively expected. We derive an analytical theory to understand the emergence of global-scale extreme events based on the concept of effective betweenness. We also articulate a cost-effective control scheme through increasing the capacity of very few hubs to suppress the cascading process of extreme events so as to protect the entire multi-layer infrastructure against global-scale breakdown.

  20. Scale orientated analysis of river width changes due to extreme flood hazards

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    G. Krapesch

    2011-08-01

    Full Text Available This paper analyses the morphological effects of extreme floods (recurrence interval >100 years and examines which parameters best describe the width changes due to erosion based on 5 affected alpine gravel bed rivers in Austria. The research was based on vertical aerial photos of the rivers before and after extreme floods, hydrodynamic numerical models and cross sectional measurements supported by LiDAR data of the rivers. Average width ratios (width after/before the flood were calculated and correlated with different hydraulic parameters (specific stream power, shear stress, flow area, specific discharge. Depending on the geomorphological boundary conditions of the different rivers, a mean width ratio between 1.12 (Lech River and 3.45 (Trisanna River was determined on the reach scale. The specific stream power (SSP best predicted the mean width ratios of the rivers especially on the reach scale and sub reach scale. On the local scale more parameters have to be considered to define the "minimum morphological spatial demand of rivers", which is a crucial parameter for addressing and managing flood hazards and should be used in hazard zone plans and spatial planning.

  1. Prediction of extreme floods in the Central Andes by means of Complex Networks

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    Boers, Niklas; Bookhagen, Bodo; Barbosa, Henrique; Marwan, Norbert; Kurths, Jürgen; Marengo, Jose

    2014-05-01

    Based on a non-linear synchronisation measure and complex network theory, we present a novel framework for the prediction of extreme events of spatially embedded, interrelated time series. This method is general in the sense that it can be applied to any type of spatially sampled time series with significant interrelations, ranging from climate observables to biological or stock market data. In this presentation, we apply our method to extreme rainfall in South America and show how this leads to the prediction of more than 60% (90% during El Niño conditions) of extreme rainfall events in the eastern Central Andes of Bolivia and northern Argentina, with only 1% false alarms. From paleoclimatic to decadal time scales, the Central Andes continue to be subject to pronounced changes in climatic conditions. In particular, our and past work shows that frequency as well as magnitudes of extreme rainfall events have increased significantly during past decades, calling for a better understanding of the involved climatic mechanisms. Due to their large spatial extend and occurrence at high elevations, these extreme events often lead to severe floods and landslides with disastrous socioeconomic impacts. They regularly affect tens of thousands of people and produce estimated costs of the order of several hundred million USD. Alongside with the societal value of predicting natural hazards, our study provides insights into the responsible climatic features and suggests interactions between Rossby waves in polar regions and large scale (sub-)tropical moisture transport as a driver of subseasonal variability of the South American monsoon system. Predictable extreme events result from the propagation of extreme rainfall from the region of Buenos Aires towards the Central Andes given characteristic atmospheric conditions. Our results indicate that the role of frontal systems originating from Rossby waves in polar latitudes is much more dominant for controlling extreme rainfall in

  2. Soil temperature regime and vulnerability due to extreme soil temperatures in Croatia

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    Sviličić, Petra; Vučetić, Višnja; Filić, Suzana; Smolić, Ante

    2016-10-01

    Soil temperature is an important factor within the climate system. Changes of trends in soil temperature and analysis of vulnerability due to heat stress can provide useful information on climate change. In this paper, the soil temperature regime was analyzed on seasonal and annual scales at depths of 2, 5, 10, 20, 30, and 50 cm at 26 sites in Croatia. Trends of maximal, mean, and minimal soil temperatures were analyzed in the periods 1961-2010 and 1981-2010. Duration of extreme soil temperatures and vulnerability due to high or low soil temperatures in the recent standard period 1981-2010 was compared with the reference climate period 1961-1990. The results show a general warming in all seasons and depths for maximal and mean temperatures in both observed periods, while only at some locations for minimal soil temperature. Warming is more pronounced in the eastern and coastal parts of Croatia in the surface layers, especially in the spring and summer season in the second period. Significant trends of maximal, minimal, and mean soil temperature in both observed periods range from 2.3 to 6.6 °C/decade, from -1.0 to 1.3 °C/decade, and from 0.1 to 2.5 °C/decade, respectively. The highest vulnerability due to heat stress at 35 °C is noted in the upper soil layers of the coastal area in both observed periods. The mountainous and northwestern parts of Croatia at surface soil layers are the most vulnerable due to low soil temperature below 0 °C. Vulnerability due to high or low soil temperature decreases with depth.

  3. Compounding Hazards Facing Nepalese Villages due to Glacial Lake Thulagi, Extreme Monsoons, and Landslides

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    Leonard, Gregory; Kargel, Jeffrey; Regmi, Dhananjay

    2014-05-01

    Thulagi Tsho is listed by ICIMOD as among the most hazardous glacial lakes in Nepal. The listing is warranted by the physiography and downstream vulnerabilities. Tal Village—along a major trekking route—and a hydroelectric dam and reservoir are notably at risk due to the potential for a glacier lake outburst flood (GLOF), an extreme summer monsoon, extreme spring snowmelt, landslides, and rockfalls. Tal is downstream from Thulagi Lake just a couple meters above river level, and ordinary monsoons already cause an approach toward flood conditions, according to residents. A high flood stage due to an extreme monsoon or unusually rapid springtime melting of a thick winter snowpack could be catastrophic. Two significant mass movements occurred recently in Tal, one having buried some structures in the village in June 2012. In a favorable note, satellite image analysis shows that Thulagi Lake has slowed its elongation in the last couple years. Furthermore, any tsunami or other flood surge would have to traverse and erode a wide end moraine in order to generate a GLOF. On the other hand, remote sensing and field observations show that wasting of Thulagi Glacier has debuttressed the northern lateral moraine, which is slipping toward the growing lake and the thinning/retreating glacier. The landslip itself is not necessarily a bad thing: it is causing a loss of gravitational potential energy of the lateral moraine, and if that process continues gradually, it will result in diminished instability. However, the debuttressing and moraine slip signifies that the moraines are unstable. Will a rapid mass movement dump into the lake? Triggers could include seismicity, extreme rainfall, or a small landslip. The risk of a serious GLOF exceeds that of Imja Lake due to Thulagi Lake's large hydrographic head and the shape of its downstream end, which could funnel and amplify a potential tsunami generated by a large mass movement into the lake. A moraine collapse into the lake would

  4. Extreme tsunami runup simulation at Babi Island due to 1992 Flores tsunami and Okushiri due to 1993 Hokkido tsunami

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    Chule Kim, Dong; Choi, Byung Ho; Kim, Kyeong Ok; Pelinovsky, Efim

    2014-05-01

    This study is based on a series of three dimensional numerical modeling experiments to understand the tsunami run-up and inundation process at the circular shape Babi Island in the Indonesia caused by 1992 Flores earthquake tsunami and at Monai valley in Okushiri Island, west part of East (Japan) Sea caused by the 1993 Hokkaido Nansei-Oki earthquake. The wave field in the coastal area is modeled within the framework of fully nonlinear dispersive Reynolds-averaged Navier-Stokes (RANS) equations solved using the FLOW3D code. Boundary conditions for this model were extracted from computed wave characteristics obtained from the 2D tsunami propagation model based on the shallow water equations. This model has shown it effectivity to explain extreme runup characteristics during the 2004 Indian Ocean tsunami and 2011 Japan tsunami (Kim et al, 2013). In case of the 1992 Flores Island tsunami the results of numerical simulation run-up results are compared with field measured run-up heights. It has good agreement with measurement and computational run-up heights. The particle velocity distribution is also computed. In the case of 1993 Okushiri tsunami the numerical simulation reproduces extreme run-up at the Monai valley (31.7 m).

  5. Predicting climate extremes – a complex network approach

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    M. Weimer

    2015-10-01

    Full Text Available Regional decadal predictions have emerged in the past few years as a research field with high application potential, especially for extremes like heat and drought periods. However, up to now the prediction skill of decadal hindcasts, as evaluated with standard methods is moderate, and for extreme values even rarely investigated. In this study, we use hindcast data from a regional climate model (CCLM for 8 regions in Europe to construct time evolving climate networks and use the network correlation threshold (link strength as a predictor for heat periods. We show that the skill of the network measure to predict the low frequency dynamics of heat periods is similar to the one of the standard approach, with the potential of being even better in some regions.

  6. Groundwater Level Changes Due to Extreme Weather—An Evaluation Tool for Sustainable Water Management

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    Jadwiga R. Ziolkowska

    2017-02-01

    Full Text Available In the past decade, extreme and exceptional droughts have significantly impacted many economic sectors in the US, especially in California, Oklahoma, and Texas. The record drought of 2011–2014 affected almost 90% of Texas areas and 95% of Oklahoma state areas. In 2011 alone, around $1.6 billion in agricultural production were lost as a result of drought in Oklahoma, and $7.6 billion in Texas. The agricultural sectors in Oklahoma and Texas rely mainly on groundwater resources from the non-replenishable Ogallala Aquifer in Panhandle and other aquifers around the states. The exceptional droughts of 2011–2014 not only caused meteorologically induced water scarcity (due to low precipitation, but also prompted farmers to overuse groundwater to maintain the imperiled production. Comprehensive studies on groundwater levels, and thus the actual water availability/scarcity across all aquifers in Oklahoma and Texas are still limited. Existing studies are mainly focused on a small number of selected sites or aquifers over a short time span of well monitoring, which does not allow for a holistic geospatial and temporal evaluation of groundwater level variations. This paper aims at addressing those issues with the proposed geospatial groundwater visualization model to assess availability of groundwater resources for agricultural, industrial, and municipal uses both in Oklahoma and Texas in the time frame of 2003–2014. The model is an evaluation tool that can be used by decision-makers for designing sustainable water management practices and by teachers and researchers for educational purposes.

  7. Peroneal island flap for wound coverage in complex injuries of the lower extremity

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    Fazal A

    2012-01-01

    Full Text Available Akil Fazal1, Haroon-ur-Rashid1, Tahseen Cheema21Section of Orthopedics, Department of Surgery, Aga Khan University, Karachi, Pakistan; 2Department of Orthopedics and Rehabilitation, University of New Mexico, Albuquerque, NM, USABackground: Complex injuries of the lower extremity pose a therapeutic challenge owing to limited availability of local soft tissue for coverage. One option in this region is the pedicled fasciocutaneous flap based on perforators of the peroneal artery. In this case series, we present our experience of the peroneal island pedicled flap for reconstruction of lower extremity wounds.Methods: Records of 18 cases of peroneal island flap admitted consecutively to the Section of Orthopedics at Aga Khan University Hospital from January 1996 to December of 2009 were studied and their outcomes determined.Results: The most common indication for coverage was open wounds due to a road traffic accident (n = 10, followed by burns (n = 3. The most common area exposed was the lower third of the leg followed by the middle third. The tibia was exposed in 11 patients. The flaps ranged in size from 35 cm2 to over 200 cm2. In 13 patients, the flaps healed uneventfully, while in the remaining five there was partial flap necrosis. In four of the latter patients, the residual wound healed with conservative measures only, but the fifth patient required further surgery to achieve acceptable coverage.Conclusion: The peroneal artery flap appears to be a simple, useful, and reliable flap in the armamentarium of the surgeon when planning soft tissue coverage of the lower extremity.Keywords: leg injuries, surgical flaps, lower extremity

  8. Mycobacterium abscessus complex bacteremia due to prostatitis after prostate biopsy.

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    Chen, Chung-Hua; Lin, Jesun; Lin, Jen-Shiou; Chen, Yu-Min

    2016-10-01

    We present the case of a 49-year-old man, who developed Mycobacterium abscessus complex (M. abscessus complex) bacteremia and prostatitis after prostate biopsy. The patient was successfully treated with amikacin with imipenem-cilastatin with clarithromycin. Infections caused by M. abscessus complex have been increasingly described as a complication associated with many invasive procedures. Invasive procedures might have contributed to the occurrence of the M. abscessus complex. Although M. abscessus complex infection is difficult to diagnose and treat, we should pay more attention to this kind of infection, and the correct treatment strategy will be achieved by physicians.

  9. Assessing extreme sea levels due to tropical cyclones in the Atlantic basin

    Science.gov (United States)

    Muis, Sanne; Lin, Ning; Verlaan, Martin; Winsemius, Hessel; Vatvani, Deepak; Ward, Philip; Aerts, Jeroen

    2017-04-01

    Tropical cyclones (TCs), including hurricanes and typhoons, are characterised by high wind speeds and low pressure and cause dangerous storm surges in coastal areas. Over the last 50 years, storm surge incidents in the Atlantic accounted for more than 1,000 deaths in the United Stated. Recent flooding disasters, such as Hurricane Katrina in New Orleans in 2005 and, Hurricane Sandy in New York in 2012, exemplify the significant TC surge risk in the United States. In this contribution, we build on Muis et al. (2016), and present a new modelling framework to simulate TC storm surges and estimate their probabilities for the Atlantic basin. In our framework we simulate the surge levels by forcing the Global Tide and Surge Model (GTSM) with wind and pressure fields from TC events. To test the method, we apply it to historical storms that occurred between 1988 and 2015 in the Atlantic Basin. We obtain high-resolution meteorological forcing by applying a parametric hurricane model (Holland 1980; Lin and Chavas 2012) to the TC extended track data set (Demuth et al. 2006; updated), which describes the position, intensity and size of the historical TCs. Preliminary results show that this framework is capable of accurately reproducing the main surge characteristics during past events, including Sandy and Katrina. While the resolution of GTSM is limited for local areas with a complex bathymetry, the overall performance of the model is satisfactory for the basin-scale application. For an accurate assessment of risk to coastal flooding in the Atlantic basin it is essential to provide reliable estimates of surge probabilities. However, the length of observed TC tracks is too short to accurately estimate the probabilities of extreme TC events. So next steps are to statistically extend the observed record to many thousands of years (e.g., Emanuel et al. 2006), in order to force GTSM with a large number of synthetic storms. Based on these synthetic simulations, we would be able to

  10. Will climate change increase the risk for critical infrastructure failures in Europe due to extreme precipitation?

    Science.gov (United States)

    Nissen, Katrin; Ulbrich, Uwe

    2016-04-01

    An event based detection algorithm for extreme precipitation is applied to a multi-model ensemble of regional climate model simulations. The algorithm determines extent, location, duration and severity of extreme precipitation events. We assume that precipitation in excess of the local present-day 10-year return value will potentially exceed the capacity of the drainage systems that protect critical infrastructure elements. This assumption is based on legislation for the design of drainage systems which is in place in many European countries. Thus, events exceeding the local 10-year return value are detected. In this study we distinguish between sub-daily events (3 hourly) with high precipitation intensities and long-duration events (1-3 days) with high precipitation amounts. The climate change simulations investigated here were conducted within the EURO-CORDEX framework and exhibit a horizontal resolution of approximately 12.5 km. The period between 1971-2100 forced with observed and scenario (RCP 8.5 and RCP 4.5) greenhouse gas concentrations was analysed. Examined are changes in event frequency, event duration and size. The simulations show an increase in the number of extreme precipitation events for the future climate period over most of the area, which is strongest in Northern Europe. Strength and statistical significance of the signal increase with increasing greenhouse gas concentrations. This work has been conducted within the EU project RAIN (Risk Analysis of Infrastructure Networks in response to extreme weather).

  11. Extreme dissipation event due to plume collision in a turbulent convection cell

    CERN Document Server

    Schumacher, Joerg

    2016-01-01

    An extreme dissipation event in the bulk of a closed three-dimensional turbulent convection cell is found to be correlated with a strong reduction of the large-scale circulation flow in the system that happens at the same time as a plume emission event from the bottom plate. The reduction in the large-scale circulation opens the possibility for a nearly frontal collision of down- and upwelling plumes and the generation of a high-amplitude thermal dissipation layer in the bulk. This collision is locally connected to a subsequent high-amplitude energy dissipation event in the form of a strong shear layer. Our analysis illustrates the impact of transitions in the large-scale structures on extreme events at the smallest scales of the turbulence, a direct link that is observed in a flow with boundary layers. We also show that detection of extreme dissipation events which determine the far-tail statistics of the dissipation fields in the bulk requires long-time integrations of the equations of motion over at least ...

  12. Extreme dissipation event due to plume collision in a turbulent convection cell

    Science.gov (United States)

    Schumacher, Jörg; Scheel, Janet D.

    2016-10-01

    An extreme dissipation event in the bulk of a closed three-dimensional turbulent convection cell is found to be correlated with a strong reduction of the large-scale circulation flow in the system that happens at the same time as a plume emission event from the bottom plate. The reduction in the large-scale circulation opens the possibility for a nearly frontal collision of down- and upwelling plumes and the generation of a high-amplitude thermal dissipation layer in the bulk. This collision is locally connected to a subsequent high-amplitude energy dissipation event in the form of a strong shear layer. Our analysis illustrates the impact of transitions in the large-scale structures on extreme events at the smallest scales of the turbulence, a direct link that is observed in a flow with boundary layers. We also show that detection of extreme dissipation events which determine the far-tail statistics of the dissipation fields in the bulk requires long-time integrations of the equations of motion over at least a hundred convective time units.

  13. On Impact Dynamics under Complex or Extreme Conditions

    KAUST Repository

    Kouraytem, Nadia

    2016-11-01

    The impact of a spherical object onto a surface of a liquid, solid or granular material, is a configuration which occurs in numerous industrial and natural phenomena. The resulting dynamics can produce complex outcomes and often occur on very short time-scales. Their study thereby requires high-speed video imaging, as is done herein. This three-part dissertation investigates widely disparate but kindred impact configurations, where the impacting object is a solid steel sphere, or a molten metal droplet. The substrate, on the other hand, is either granular material, a liquid, or solid ice. Therefore both fluid mechanics and thermodynamics play a key role in some of these dynamics. Part I, investigates the penetration depth of a steel sphere which impacts onto a granular bed containing a mixture of grains of two different sizes. The addition of smaller grains within a bed of larger grains can promote a “lubrication” effect and deeper penetration of the sphere. However, there needs to be enough mass fraction of the smaller grains so that they get lodged between the larger grains and are not simply like isolated rattlers inside the voids between the larger grains. This lubrication occurs even though the addition of the small grains increases the overall packing fraction of the bed. We compare the enhanced penetration for the mixtures to a simple interpolative model based on the results for monodispersed media of the constitutive sizes. The strongest lubrication is observed for large irregular shaped Ottawa sand grains, which are seeded with small spherical glass beads. Part II, tackles the topic of a molten metal drop impacting onto a pool of water. When the drop temperature is far above the boiling temperature of water, a continuous vapor layer can form at the interface between the metal and water, in what is called the Leidenfrost phenomenon. This vapor layer can become unstable forming what is called a vapor explosion, which can break up the molten metal drop

  14. Lower-Extremity Weakness in a Teenager Due to Thyrotoxic Periodic Paralysis.

    Science.gov (United States)

    Thornton, Matthew D

    2017-04-01

    Thyrotoxic hypokalemic paralysis is the hallmark of thyrotoxic periodic paralysis (TPP). TPP is a potentially deadly complication of hyperthyroidism that occurs because of rapid and dramatic intracellular shift of potassium. This transference results in severe hypokalemia and clinically manifests itself as muscle weakness or paralysis. This condition predominantly affects males of Asian descent, and its presentation can range from mild to severe, as seen in our case. We present the case of a 15-year-old Asian-American male who presented to a tertiary-care pediatric emergency department complaining of generalized weakness and flaccid paralysis of his lower extremities. The differential for such a complaint is extremely broad, and the symptoms can result from etiologies arising from the cerebral cortex, the spinal cord, peripheral nerves, the neuromuscular junction, or even the muscles themselves. Our patient was found to have an extremely low serum potassium concentration, as well as an electrocardiogram that revealed a prolonged QT interval and right bundle branch block. The etiology of these abnormalities and the patient's symptoms was found to be undiagnosed and uncontrolled hyperthyroidism from Grave's disease, which resulted in this dramatic presentation of thyrotoxic hypokalemic paralysis. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: This entity is common in Asia but still somewhat rare in the United States and other Western countries. Our case illustrates that careful history taking and a focused diagnostic evaluation, in conjunction with having an awareness of this disease, can help expedite diagnosis and management, as well as avoid unnecessary and potential harmful testing in the emergency department setting. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. Pregnant woman with an extremely small uterus due to pelvic irradiation in childhood.

    Science.gov (United States)

    Watanabe, Takashi; Matsubara, Shigeki; Saito, Yutaka; Usui, Rie; Mugishima, Hideo; Suzuki, Mitsuaki

    2012-03-01

    A female cancer survivor, having suffered malignant lymphoma during childhood and received radio- and chemotherapy, became pregnant. Her uterus was extremely small and in the 22nd week of gestation, acute uterine contractions occurred, leading to preterm delivery and resulting in the death of the infant. Pelvic irradiation in childhood was considered to have caused a small uterus and thus brought on preterm delivery. The younger the patient, the more vulnerable the uterus is to irradiation. The exposure dose to the uterus in pediatric cancer patients should therefore be reduced, especially in younger patients. The cooperation of pediatric cancer specialists and obstetricians is necessary to preserve the future fertility of female cancer survivors.

  16. Research on complex networks' repairing characteristics due to cascading failure

    Science.gov (United States)

    Chaoqi, Fu; Ying, Wang; Xiaoyang, Wang

    2017-09-01

    In reality, most of the topological structures of complex networks are not ideal. Considering the restrictions from all aspects, we cannot timely adjust and improve network defects. Once complex networks collapse under cascading failure, an appropriate repair strategy must be implemented. This repair process is divided into 3 kinds of situations. Based on different types of opening times, we presented 2 repair modes, and researched 4 kinds of repair strategies. Results showed that network efficiency recovered faster when the repair strategies were arranged in descending order by parameters under the immediate opening condition. However, the risk of secondary failure and additional expansion capacity were large. On the contrary, when repair strategies were in ascending order, the demand for additional capacity caused by secondary failure was greatly saved, but the recovery of network efficiency was relatively slow. Compared to immediate opening, delayed opening alleviated the contradiction between network efficiency and additional expansion capacity, particularly to reduce the risk of secondary failure. Therefore, different repair methods have different repair characteristics. This paper investigates the impact of cascading effects on the network repair process, and by presenting a detailed description of the status of each repaired node, helps us understand the advantages and disadvantages of different repair strategies.

  17. Extreme Wave Simulation due to Typhoon Bolaven based on locally Enhanced Fine-Mesh Unstructured Grid Model

    Science.gov (United States)

    Kim, Kyeong Ok; Choi, Byung Ho; Jung, Kyung Tae

    2016-04-01

    The performance of an integrally coupled wave-tide-surge model using the unstructured mesh system has been tested for the typhoon Bolaven which is regarded as the most powerful storm to strike the Korean Peninsula in nearly a decade with wind gusts measured up to 50 m/s, causing serious damages with 19 victims. Use of the unstructured mesh in coastal sea regions of marginal scale allows all energy from deep to shallow waters to be seamlessly followed; the physics of wave-circulation interactions can be then correctly resolved. The model covers the whole Yellow and East China Seas with locally refined meshes near the regions of Gageo Island (offshore southwestern corner of the Korean Peninsula) and south of Jeju Island (Gangjeong and Seogwipo ports). The wind and pressure fields during the passage of typhoon Bolaven are generated by the blending method. Generally the numerical atmospheric model cannot satisfactorily reproduce the strength of typhoons due to dynamic and resolution restrictions. In this study we could achieve an improved conservation of the typhoon strength by blending the Holland typhoon model result by the empirical formula onto the ambient meteorological fields of NCEP dataset. The model results are compared with the observations and the model performance is then evaluated. The computed wave spectrums for one and two dimensions are compared with the observation in Ieodo station. Results show that the wind wave significantly enhances the current intensity and surge elevation, addressing that to incorporate the wave-current interaction effect in the wave-tide-surge coupled model is important for the accurate prediction of current and sea surface elevation as well as extreme waves in shallow coastal sea regions. The resulting modeling system can be used for hindcasting and forecasting the wave-tide-surges in marine environments with complex coastlines, shallow water depth and fine sediment.

  18. Management of Complex Extremity Injuries: Tourniquets, Compartment Syndrome Detection, Fasciotomy, and Amputation Care

    Science.gov (United States)

    2012-01-01

    E mail address: robert.rush1@us.army.mil KEYWORDS Extremity injury Mangled extremity Amputation Compartment syndrome Fasciotomy Prosthesis ...definitive repair. For ray amputations of the foot , removing the big toe in most cases is worse than a transmetatarsal amputation due to lack of...from lack of total contact with the prosthesis and requires refitting. Heterotopic ossification (HO), the aberrant formation of mature, lamellar bone in

  19. Increased jump height with an external focus due to enhanced lower extremity joint kinetics.

    Science.gov (United States)

    Wulf, Gabriele; Dufek, Janet S

    2009-10-01

    Individuals jump higher when they adopt an external focus of attention, relative to an internal focus or no focus of attention (G. Wulf, T. Zachry, C. Granados, & J. S. Dufek, 2007). In the present study, the authors determined the underlying cause of this effect. Participants performed a vertical jump-and-reach task for (a) an external focus condition (i.e., participants focused on the rungs of a Vertec [Perform Better, Cranston, RI] measurement device that they touched) and (b) an internal focus condition (i.e., participants focused on the finger with which they touched the rungs). Participants' jump height, center-of-mass displacement, jump impulse, and lower extremity joint moments were greater with an external focus compared with an internal focus. These results suggest that participants jump higher by producing greater forces when they adopt an external focus. This finding adds to evidence that an external focus facilitates the production of effective and efficient movement patterns.

  20. [Malnutrition due to an extremely 'healthy' diet; a new eating disorder?].

    Science.gov (United States)

    Nauta, K; Toxopeus, K; Eekhoff, E M W

    2016-01-01

    A 71-year-old male was admitted to our hospital with heart failure, cachexia and biochemical disturbances due to a diet consisting of exclusively vegetables, oil and water. Our investigations showed that this diet was a consequence of an excessive preoccupation with health. The patient did not meet criteria for an eating disorder or other DSM-IV psychiatric disorder. We conclude that malnutrition due to health fad diets may be an underestimated medical problem. There is no specific psychopathological disorder that covers this behaviour, and there is no knowledge of its epidemiology. Popular literature is paying a great deal attention to orthorexia nervosa, an alleged eating disorder that describes a pathological obsession with healthy food. In medical literature this concept has been largely neglected, although eating disorder specialists frequently observe this behaviour in their practice. More clinical and scientific attention for this phenomenon is necessary to determine its epidemiology, validity and clinical picture.

  1. Customized toric intraocular lens implantation for correction of extreme corneal astigmatism due to corneal scarring

    Directory of Open Access Journals (Sweden)

    R Bassily

    2010-03-01

    Full Text Available R Bassily, J LuckOphthalmology Department, Royal United Hospital, Combe Park, Bath, UKAbstract: A 76-year-old woman presented with decreased visual function due to cataract formation. Twenty-five years prior she developed right sided corneal ulceration that left her with 10.8 diopters (D of irregular astigmatism at 71.8° (steep axis. Her uncorrected visual acuity was 6/24 and could only ever wear a balanced lens due to the high cylindrical error. Cataract surgery was planned with a custom designed toric intraocular lens (IOL with +16.0 D sphere inserted via a wound at the steep axis of corneal astigmatism. Postoperative refraction was -0.75/+1.50 × 177° with a visual acuity of 6/9 that has remained unchanged at six-week follow-up with no IOL rotation. This case demonstrates the value of high power toric IOLs for the correction of pathological corneal astigmatism.Keywords: intraocular lens, corneal ulceration, visual acuity, scarring

  2. Complex network based techniques to identify extreme events and (sudden) transitions in spatio-temporal systems

    CERN Document Server

    Marwan, Norbert

    2015-01-01

    We present here two promising techniques for the application of the complex network approach to continuous spatio-temporal systems that have been developed in the last decade and show large potential for future application and development of complex systems analysis. First, we discuss the transforming of a time series from such systems to a complex network. The natural approach is to calculate the recurrence matrix and interpret such as the adjacency matrix of an associated complex network, called recurrence network. Using complex network measures, such as transitivity coefficient, we demonstrate that this approach is very efficient for identifying qualitative transitions in observational data, e.g., when analyzing paleoclimate regime transitions. Second, we demonstrate the use of directed spatial networks constructed from spatio-temporal measurements of such systems that can be derived from the synchronized-in-time occurrence of extreme events in different spatial regions. Although there are many possibiliti...

  3. A extremely rare case of cervical intramedullary granuloma due to Brucella accompanied by Chiari Type-1 malformation.

    Science.gov (United States)

    Tufan, Kadir; Aydemir, Fatih; Sarica, Feyzi Birol; Kursun, Ebru; Kardes, Özgür; Cekinmez, Melih; Caner, Hakan

    2014-01-01

    Chiari Type-1 malformation is displacement of the cerebellar tonsils through the foramen magnum into the cervical spine and usually does not exceed the level of C2. It is 50-70% associated with syringomyelia. Nervous system involvement due to brucellosis is called neurobrucellosis, and neurological involvement rate has been reported an average of 3-5%, ranging between 3% and 25% at different series. Intramedullary abscess or granuloma due to Brucella is extremely rare. Hence far, six cases have been reported in the literature and only two of these cases were reported as intramedullary granuloma. This case is presented in order to remind the importance of the cervical cord granuloma which was presented once before in the literature and to emphasize the importance of evaluation of patient history, clinical and radiological findings together in the evaluation of a patient.

  4. Dismounted complex blast injuries: patterns of injuries and resource utilization associated with the multiple extremity amputee.

    Science.gov (United States)

    Fleming, Mark; Waterman, Scott; Dunne, James; D'Alleyrand, Jean-Claude; Andersen, Romney C

    2012-01-01

    The objective of this report is to analyze the resource utilization and injury patterns of complex dismounted blast injuries. A retrospective review of U.S. service members injured in combat between 2007 and 2010 was conducted. Data analyzed included age, injury mechanism, amputated limbs, number and type of associated injuries, blood products utilized, intensive care unit length of stay (ILOS), hospital length of stay (HLOS) and the Injury Severity Score (ISS). Patients were stratified based on the number of amputations. Sixty-three patients comprised the multiple extremity amputation (MEA) group. Ninety-eight percent sustained injuries from an improvised explosive device (IED) and 96% were dismounted. The ISS, number of surgical encounters, blood products utilized and ILOS were all clinically significantly different than controls. Care of multiple extremity amputees involves the utilization of significant resources. This knowledge may better help surgeons and administrators allocate assets at hospitals, both military and civilian, who care for this complex and challenging patient population.

  5. Complex extreme learning machine applications in terahertz pulsed signals feature sets.

    Science.gov (United States)

    Yin, X-X; Hadjiloucas, S; Zhang, Y

    2014-11-01

    This paper presents a novel approach to the automatic classification of very large data sets composed of terahertz pulse transient signals, highlighting their potential use in biochemical, biomedical, pharmaceutical and security applications. Two different types of THz spectra are considered in the classification process. Firstly a binary classification study of poly-A and poly-C ribonucleic acid samples is performed. This is then contrasted with a difficult multi-class classification problem of spectra from six different powder samples that although have fairly indistinguishable features in the optical spectrum, they also possess a few discernable spectral features in the terahertz part of the spectrum. Classification is performed using a complex-valued extreme learning machine algorithm that takes into account features in both the amplitude as well as the phase of the recorded spectra. Classification speed and accuracy are contrasted with that achieved using a support vector machine classifier. The study systematically compares the classifier performance achieved after adopting different Gaussian kernels when separating amplitude and phase signatures. The two signatures are presented as feature vectors for both training and testing purposes. The study confirms the utility of complex-valued extreme learning machine algorithms for classification of the very large data sets generated with current terahertz imaging spectrometers. The classifier can take into consideration heterogeneous layers within an object as would be required within a tomographic setting and is sufficiently robust to detect patterns hidden inside noisy terahertz data sets. The proposed study opens up the opportunity for the establishment of complex-valued extreme learning machine algorithms as new chemometric tools that will assist the wider proliferation of terahertz sensing technology for chemical sensing, quality control, security screening and clinic diagnosis. Furthermore, the proposed

  6. Game theory and extremal optimization for community detection in complex dynamic networks.

    Directory of Open Access Journals (Sweden)

    Rodica Ioana Lung

    Full Text Available The detection of evolving communities in dynamic complex networks is a challenging problem that recently received attention from the research community. Dynamics clearly add another complexity dimension to the difficult task of community detection. Methods should be able to detect changes in the network structure and produce a set of community structures corresponding to different timestamps and reflecting the evolution in time of network data. We propose a novel approach based on game theory elements and extremal optimization to address dynamic communities detection. Thus, the problem is formulated as a mathematical game in which nodes take the role of players that seek to choose a community that maximizes their profit viewed as a fitness function. Numerical results obtained for both synthetic and real-world networks illustrate the competitive performance of this game theoretical approach.

  7. Analysis of spatial and temporal extreme monsoonal rainfall over South Asia using complex networks

    Energy Technology Data Exchange (ETDEWEB)

    Malik, Nishant [Potsdam Institute for Climate Impact Research, P.O. Box 60 12 03, Potsdam (Germany); University of Potsdam, Institute of Physics, Potsdam-Golm (Germany); Bookhagen, Bodo [University of California Santa Barbara, Department of Geography, Santa Barbara, CA (United States); Marwan, Norbert [Potsdam Institute for Climate Impact Research, P.O. Box 60 12 03, Potsdam (Germany); Kurths, Juergen [Potsdam Institute for Climate Impact Research, P.O. Box 60 12 03, Potsdam (Germany); Humboldt University, Department of Physics, Berlin (Germany)

    2012-08-15

    We present a detailed analysis of summer monsoon rainfall over the Indian peninsular using nonlinear spatial correlations. This analysis is carried out employing the tools of complex networks and a measure of nonlinear correlation for point processes such as rainfall, called event synchronization. This study provides valuable insights into the spatial organization, scales, and structure of the 90th and 94th percentile rainfall events during the Indian summer monsoon (June-September). We furthermore analyse the influence of different critical synoptic atmospheric systems and the impact of the steep Himalayan topography on rainfall patterns. The presented method not only helps us in visualising the structure of the extreme-event rainfall fields, but also identifies the water vapor pathways and decadal-scale moisture sinks over the region. Furthermore a simple scheme based on complex networks is presented to decipher the spatial intricacies and temporal evolution of monsoonal rainfall patterns over the last 6 decades. (orig.)

  8. Game theory and extremal optimization for community detection in complex dynamic networks.

    Science.gov (United States)

    Lung, Rodica Ioana; Chira, Camelia; Andreica, Anca

    2014-01-01

    The detection of evolving communities in dynamic complex networks is a challenging problem that recently received attention from the research community. Dynamics clearly add another complexity dimension to the difficult task of community detection. Methods should be able to detect changes in the network structure and produce a set of community structures corresponding to different timestamps and reflecting the evolution in time of network data. We propose a novel approach based on game theory elements and extremal optimization to address dynamic communities detection. Thus, the problem is formulated as a mathematical game in which nodes take the role of players that seek to choose a community that maximizes their profit viewed as a fitness function. Numerical results obtained for both synthetic and real-world networks illustrate the competitive performance of this game theoretical approach.

  9. Extreme sensory processing patterns show a complex association with depression, and impulsivity, alexithymia, and hopelessness.

    Science.gov (United States)

    Serafini, Gianluca; Gonda, Xenia; Canepa, Giovanna; Pompili, Maurizio; Rihmer, Zoltan; Amore, Mario; Engel-Yeger, Batya

    2017-03-01

    The involvement of extreme sensory processing patterns, impulsivity, alexithymia, and hopelessness was hypothesized to contribute to the complex pathophysiology of major depression and bipolar disorder. However, the nature of the relation between these variables has not been thoroughly investigated. This study aimed to explore the association between extreme sensory processing patterns, impulsivity, alexithymia, depression, and hopelessness. We recruited 281 euthymic participants (mean age=47.4±12.1) of which 62.3% with unipolar major depression and 37.7% with bipolar disorder. All participants completed the Adolescent/Adult Sensory Profile (AASP), Toronto Alexithymia Scale (TAS-20), second version of the Beck Depression Inventory (BDI-II), Barratt Impulsivity Scale (BIS), and Beck Hopelessness Scale (BHS). Lower registration of sensory input showed a significant correlation with depression, impulsivity, attentional/motor impulsivity, and alexithymia. It was significantly more frequent among participants with elevated hopelessness, and accounted for 22% of the variance in depression severity, 15% in greater impulsivity, 36% in alexithymia, and 3% in hopelessness. Elevated sensory seeking correlated with enhanced motor impulsivity and decreased non-planning impulsivity. Higher sensory sensitivity and sensory avoiding correlated with depression, impulsivity, and alexithymia. The study was limited by the relatively small sample size and cross-sectional nature of the study. Furthermore, only self-report measures that may be potentially biased by social desirability were used. Extreme sensory processing patterns, impulsivity, alexithymia, depression, and hopelessness may show a characteristic pattern in patients with major affective disorders. The careful assessment of sensory profiles may help in developing targeted interventions and improve functional/adaptive strategies. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. Is there Complex Trauma Experience typology for Australian's experiencing extreme social disadvantage and low housing stability?

    Science.gov (United States)

    Keane, Carol A; Magee, Christopher A; Kelly, Peter J

    2016-11-01

    Traumatic childhood experiences predict many adverse outcomes in adulthood including Complex-PTSD. Understanding complex trauma within socially disadvantaged populations has important implications for policy development and intervention implementation. This paper examined the nature of complex trauma experienced by disadvantaged individuals using a latent class analysis (LCA) approach. Data were collected through the large-scale Journeys Home Study (N=1682), utilising a representative sample of individuals experiencing low housing stability. Data on adverse childhood experiences, adulthood interpersonal trauma and relevant covariates were collected through interviews at baseline (Wave 1). Latent class analysis (LCA) was conducted to identify distinct classes of childhood trauma history, which included physical assault, neglect, and sexual abuse. Multinomial logistic regression investigated childhood relevant factors associated with class membership such as biological relationship of primary carer at age 14 years and number of times in foster care. Of the total sample (N=1682), 99% reported traumatic adverse childhood experiences. The most common included witnessing of violence, threat/experience of physical abuse, and sexual assault. LCA identified six distinct childhood trauma history classes including high violence and multiple traumas. Significant covariate differences between classes included: gender, biological relationship of primary carer at age 14 years, and time in foster care. Identification of six distinct childhood trauma history profiles suggests there might be unique treatment implications for individuals living in extreme social disadvantage. Further research is required to examine the relationship between these classes of experience, consequent impact on adulthood engagement, and future transitions though homelessness.

  11. Conformational changes in the bilirubin-human serum albumin complex at extreme alkaline pH

    DEFF Research Database (Denmark)

    Honoré, B; Frandsen, P C

    1986-01-01

    Light-absorption, c.d. and fluorescence of the bilirubin-albumin complex were investigated at extreme alkaline pH. Above pH 11.1 albumin binds the bilirubin molecule, twisted oppositely to the configuration at more neutral pH. On the basis of light-absorption it is shown that two alkaline...... transitions occur. The first alkaline transition takes place at pH between 11.3 and 11.8, co-operatively dissociating at least six protons. The second alkaline transition takes place at pH between 11.8 and 12.0. It probably implies a reversible unfolding of the albumin molecule, increasing the distance...

  12. Analysis and Modelling of Extreme Wind Speed Distributions in Complex Mountainous Regions

    Science.gov (United States)

    Laib, Mohamed; Kanevski, Mikhail

    2016-04-01

    Modelling of wind speed distributions in complex mountainous regions is an important and challenging problem which interests many scientists from several fields. In the present research, high frequency (10 min) Swiss wind speed monitoring data (IDAWEB service, Meteosuisse) are analysed and modelled with different parametric distributions (Weibull, GEV, Gamma, etc.) using maximum likelihood method. In total, 111 stations placed in different geomorphological units and at different altitude (from 203 to 3580 meters) are studied. Then, this information is used for training machine learning algorithms (Extreme Learning Machines, Support vector machine) to predict the distribution at new places, potentially useful for aeolian energy generation. An important part of the research deals with the construction and application of a high dimensional input feature space, generated from digital elevation model. A comprehensive study was carried out using feature selection approach to get the best model for the prediction. The main results are presented as spatial patterns of distributions' parameters.

  13. Triacylglycerol infusion improves exercise endurance in patients with mitochondrial myopathy due to complex I deficiency

    NARCIS (Netherlands)

    Roef, MJ; de Meer, K; Reijngoud, DJ; Straver, HWHC; de Barse, M; Kalhan, SC; Berger, R

    2002-01-01

    Background: A high-fat diet has been recommended for the treatment of patients with mitochondrial myopathy due to complex I (NADH dehydrogenase) deficiency (CID). Objective: This study evaluated the effects of intravenous infusion of isoenergetic amounts of triacylglycerol or glucose on substrate ox

  14. Strain evolution in Si substrate due to implantation of MeV ion observed by extremely asymmetric x-ray diffraction

    Science.gov (United States)

    Emoto, T.; Ghatak, J.; Satyam, P. V.; Akimoto, K.

    2009-08-01

    We studied the strain introduced in a Si(111) substrate due to MeV ion implantation using extremely asymmetric x-ray diffraction and measured the rocking curves of asymmetrical 113 diffraction for the Si substrates implanted with a 1.5 MeV Au2+ ion at fluence values of 1×1013, 5×1013, and 1×1014/cm2. The measured curves consisted of a bulk peak and accompanying subpeak with an interference fringe. The positional relationship of the bulk peak to the subpeak and the intensity variation of those peaks with respect to the wavelengths of the x rays indicated that crystal lattices near the surface were strained; the lattice spacing of surface normal (111) planes near the surface was larger than that of the bulk. Detailed strain profiles along the depth direction were successfully estimated using a curve-fitting method based on Darwin's dynamical diffraction theory. Comparing the shapes of resultant strain profiles, we found that a strain evolution rapidly occurred within a depth of ˜300 nm at fluence values between 1×1013 and 5×1013/cm2. This indicates that formation of the complex defects progressed near the surface when the fluence value went beyond a critical value between 1×1013 and 5×1013/cm2 and the defects brought a large strain to the substrate.

  15. Extreme total solar irradiance due to cloud enhancement at sea level of the NE Atlantic coast of Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Piacentini, Ruben D. [Instituto de Fisica Rosario (CONICET-Universidad Nacional de Rosario), 27 de Febrero 210bis, 2000 Rosario (Argentina); Facultad de Ciencias Exactas, Ingenieria y Agrimensura, Universidad Nacional de Rosario, Pellegrini 250, 2000 Rosario (Argentina); Salum, Graciela M. [Instituto de Fisica Rosario (CONICET-Universidad Nacional de Rosario), 27 de Febrero 210bis, 2000 Rosario (Argentina); Facultad Regional Concepcion del Uruguay, Universidad Tecnologica Nacional, Concepcion del Uruguay (Argentina); Fraidenraich, Naum; Tiba, Chigueru [Grupo de Pesquisas em Fontes Alternativas de Energia, Universidade Federal de Pernambuco, Av. Prof. Luiz Freire, 1000 - 50.740-540, Recife, PE (Brazil)

    2011-01-15

    Extraterrestrial total solar irradiance, usually called Solar Constant, is attenuated by the atmosphere in different proportions, depending mainly on solar zenith angle and altitude of the measurement point. In this work, it is presented very high and extreme horizontal plane measurements of global solar irradiance that in some days overpassed the Solar Constant corrected by the actual Sun-Earth distance (CSC). They were obtained at sea level of the intertropical Atlantic coast, in the city of Recife, Brazil, in the period February 2008-January 2009. Extreme total solar irradiance values larger than CSC were measured during 3.4% of the days of the total registered period. This percentage increases to 7.4% for global solar irradiance within 95.1-100% of the CSC and to 15.3% within 90.1-95% of the CSC. The largest extreme total solar irradiance value, 1477 {+-} 30 W/m{sup 2}, was registered the 28th of March 2008 at 11:34 local time (UT - 3h). It overpassed by 7.9% the CSC value for this day (1369.4 W/m{sup 2}) and by 42.3% the estimated value of the clear sky Iqbal C radiation model (1037.7 W/m{sup 2}). The observation of extreme values should be taken into account in the study of solar radiation effects related to materials exposed to the outside, UV index and biological effects, among others. Also, the detailed knowledge of this interesting effect may contribute significantly to clarify physical aspects about the interaction of global solar radiation with the ecosystem and climate change. (author)

  16. Trends in the number of extreme hot SST days along the Canary Upwelling System due to the influence of upwelling

    Directory of Open Access Journals (Sweden)

    Xurxo Costoya

    2014-07-01

    Full Text Available Trends in the number of extreme hot days (days with SST anomalies higher than the 95% percentile were analyzed along the Canary Upwelling Ecosystem (CUE over the period 1982- 2012 by means of SST data retrieved from NOAA OI1/4 Degree. The analysis will focus on the Atlantic Iberian sector and the Moroccan sub- region where upwelling is seasonal (spring and summer are permanent, respectively. Trends were analyzed both near coast and at the adjacent ocean where the increase in the number of extreme hot days is higher. Changes are clear at annual scale with an increment of 9.8±0.3 (9.7±0.1 days dec-1 near coast and 11.6±0.2 (13.5±0.1 days dec-1 at the ocean in the Atlantic Iberian sector (Moroccan sub-region. The differences between near shore and ocean trends are especially patent for the months under intense upwelling conditions. During that upwelling season the highest differences in the excess of extreme hot days between coastal and ocean locations (Δn(#days dec-1 occur at those regions where coastal upwelling increase is high. Actually, Δn and upwelling trends have shown to be significantly correlated in both areas, R=0.88 (p<0.01 at the Atlantic Iberian sector and R=0.67 (p<0.01 at the Moroccan sub-region.

  17. Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations

    DEFF Research Database (Denmark)

    Grønborg, Sabine; Darin, Niklas; Miranda, Maria J

    2017-01-01

    described in heterozygous form in patients with familial paraganglioma/pheochromocytoma and/or renal cell cancer. This is only the second example in the literature where one specific SDHx mutation is associated with both recessive mitochondrial disease in one patient and familial paraganglioma......Isolated complex II deficiency is a rare cause of mitochondrial disease and bi-allelic mutations in SDHB have been identified in only a few patients with complex II deficiency and a progressive neurological phenotype with onset in infancy. On the other hand, heterozygous SDHB mutations are a well......-known cause of familial paraganglioma/pheochromocytoma and renal cell cancer. Here, we describe two additional patients with respiratory chain deficiency due to bi-allelic SDHB mutations. The patients' clinical, neuroradiological, and biochemical phenotype is discussed according to current knowledge...

  18. Complex layered dental restorations: Are they recognizable and do they survive extreme conditions?

    Science.gov (United States)

    Soon, Alistair S; Bush, Mary A; Bush, Peter J

    2015-09-01

    Recent research has shown that restorative dental materials can be recognized by microscopy and elemental analysis (scanning electron microscopy/energy dispersive X-ray spectroscopy and X-ray fluorescence; SEM/EDS and XRF) and that this is possible even in extreme conditions, such as cremation. These analytical methods and databases of dental materials properties have proven useful in DVI (disaster victim identification) of a commercial plane crash in 2009, and in a number of other victim identification cases. Dental materials appear on the market with ever expanding frequency. With their advent, newer methods of restoration have been proposed and adopted in the dental office. Methods might include placing multiple layers of dental materials, where they have different properties including adhesion, viscosity, or working time. These different dental materials include filled adhesives, flowable resins, glass ionomer cements, composite resins, liners and sealants. With possible combinations of different materials in these restorations, the forensic odontologist is now confronted with a new difficulty; how to recognize each individual material. The question might be posed if it is even possible to perform this task. Furthermore, an odontologist might be called upon to identify a victim under difficult circumstances, such as when presented with fragmented or incinerated remains. In these circumstances the ability to identify specific dental materials could assist in the identification of the deceased. Key to use of this information is whether these new materials and methods are detailed in the dental chart. Visual or radiographic inspection may not reveal the presence of a restoration, let alone the possible complex nature of that restoration. This study demonstrates another scientific method in forensic dental identification.

  19. Extreme oceanographic forcing and coastal response due to the 2015-2016 El Niño.

    Science.gov (United States)

    Barnard, Patrick L; Hoover, Daniel; Hubbard, David M; Snyder, Alex; Ludka, Bonnie C; Allan, Jonathan; Kaminsky, George M; Ruggiero, Peter; Gallien, Timu W; Gabel, Laura; McCandless, Diana; Weiner, Heather M; Cohn, Nicholas; Anderson, Dylan L; Serafin, Katherine A

    2017-02-14

    The El Niño-Southern Oscillation is the dominant mode of interannual climate variability across the Pacific Ocean basin, with influence on the global climate. The two end members of the cycle, El Niño and La Niña, force anomalous oceanographic conditions and coastal response along the Pacific margin, exposing many heavily populated regions to increased coastal flooding and erosion hazards. However, a quantitative record of coastal impacts is spatially limited and temporally restricted to only the most recent events. Here we report on the oceanographic forcing and coastal response of the 2015-2016 El Niño, one of the strongest of the last 145 years. We show that winter wave energy equalled or exceeded measured historical maxima across the US West Coast, corresponding to anomalously large beach erosion across the region. Shorelines in many areas retreated beyond previously measured landward extremes, particularly along the sediment-starved California coast.

  20. Extreme oceanographic forcing and coastal response due to the 2015–2016 El Niño

    Science.gov (United States)

    Barnard, Patrick; Hoover, Daniel J.; Hubbard, David M.; Snyder, Alexander; Ludka, Bonnie C.; Allan, Jonathan; Kaminsky, George M.; Ruggiero,; Gallien, Timu W.; Gabel, Laura; McCandless, Diana; Weiner, Heather M.; Cohn, Nicholas; Anderson, Dylan L.; Serafin, Katherine A.

    2017-01-01

    The El Niño-Southern Oscillation is the dominant mode of interannual climate variability across the Pacific Ocean basin, with influence on the global climate. The two end members of the cycle, El Niño and La Niña, force anomalous oceanographic conditions and coastal response along the Pacific margin, exposing many heavily populated regions to increased coastal flooding and erosion hazards. However, a quantitative record of coastal impacts is spatially limited and temporally restricted to only the most recent events. Here we report on the oceanographic forcing and coastal response of the 2015–2016 El Niño, one of the strongest of the last 145 years. We show that winter wave energy equalled or exceeded measured historical maxima across the US West Coast, corresponding to anomalously large beach erosion across the region. Shorelines in many areas retreated beyond previously measured landward extremes, particularly along the sediment-starved California coast.

  1. Extreme oceanographic forcing and coastal response due to the 2015-2016 El Niño

    Science.gov (United States)

    Barnard, Patrick L.; Hoover, Daniel; Hubbard, David M.; Snyder, Alex; Ludka, Bonnie C.; Allan, Jonathan; Kaminsky, George M.; Ruggiero, Peter; Gallien, Timu W.; Gabel, Laura; McCandless, Diana; Weiner, Heather M.; Cohn, Nicholas; Anderson, Dylan L.; Serafin, Katherine A.

    2017-02-01

    The El Niño-Southern Oscillation is the dominant mode of interannual climate variability across the Pacific Ocean basin, with influence on the global climate. The two end members of the cycle, El Niño and La Niña, force anomalous oceanographic conditions and coastal response along the Pacific margin, exposing many heavily populated regions to increased coastal flooding and erosion hazards. However, a quantitative record of coastal impacts is spatially limited and temporally restricted to only the most recent events. Here we report on the oceanographic forcing and coastal response of the 2015-2016 El Niño, one of the strongest of the last 145 years. We show that winter wave energy equalled or exceeded measured historical maxima across the US West Coast, corresponding to anomalously large beach erosion across the region. Shorelines in many areas retreated beyond previously measured landward extremes, particularly along the sediment-starved California coast.

  2. A finite element lower extremity and pelvis model for predicting bone injuries due to knee bolster loading

    NARCIS (Netherlands)

    Rooij, L. van; Hoof, J. van; Barbir, A.; Made, R. van der; Slaats, P.M.A.; McCann, M.J.; Ridella, S.A.; Rupp, J.D.

    2004-01-01

    Injuries to the knee-thigh-hip (KTH) complex in frontal motor vehicle crashes are of substantial concern because of their frequency and potential to result in long-term disability. Current frontal impact Anthropometric Test Dummies (ATDs) have been shown to respond differently than human cadavers un

  3. Risk factors and outcomes for patients with bloodstream infection due to Acinetobacter baumannii-calcoaceticus complex.

    Science.gov (United States)

    Chopra, Teena; Marchaim, Dror; Johnson, Paul C; Awali, Reda A; Doshi, Hardik; Chalana, Indu; Davis, Naomi; Zhao, Jing J; Pogue, Jason M; Parmar, Sapna; Kaye, Keith S

    2014-08-01

    Identifying patients at risk for bloodstream infection (BSI) due to Acinetobacter baumannii-Acinetobacter calcoaceticus complex (ABC) and providing early appropriate therapy are critical for improving patient outcomes. A retrospective matched case-control study was conducted to investigate the risk factors for BSI due to ABC in patients admitted to the Detroit Medical Center (DMC) between January 2006 and April 2009. The cases were patients with BSI due to ABC; the controls were patients not infected with ABC. Potential risk factors were collected 30 days prior to the ABC-positive culture date for the cases and 30 days prior to admission for the controls. A total of 245 case patients were matched with 245 control patients. Independent risk factors associated with BSI due to ABC included a Charlson's comorbidity score of ≥ 3 (odds ratio [OR], 2.34; P = 0.001), a direct admission from another health care facility (OR, 4.63; P < 0.0001), a prior hospitalization (OR, 3.11; P < 0.0001), the presence of an indwelling central venous line (OR, 2.75; P = 0.011), the receipt of total parenteral nutrition (OR, 21.2; P < 0.0001), the prior receipt of β-lactams (OR, 3.58; P < 0.0001), the prior receipt of carbapenems (OR, 3.18; P = 0.006), and the prior receipt of chemotherapy (OR, 15.42; P < 0.0001). The median time from the ABC-positive culture date to the initiation of the appropriate antimicrobial therapy was 2 days (interquartile range [IQR], 1 to 3 days). The in-hospital mortality rate was significantly higher among case patients than among control patients (OR, 3.40; P < 0.0001). BSIs due to ABC are more common among critically ill and debilitated institutionalized patients, who are heavily exposed to health care settings and invasive devices.

  4. Rainfall extremes, weather and climatic characterization over complex terrain: A data-driven approach based on signal enhancement methods and extreme value modeling

    Science.gov (United States)

    Pineda, Luis E.; Willems, Patrick

    2017-04-01

    Weather and climatic characterization of rainfall extremes is both of scientific and societal value for hydrometeorogical risk management, yet discrimination of local and large-scale forcing remains challenging in data-scarce and complex terrain environments. Here, we present an analysis framework that separate weather (seasonal) regimes and climate (inter-annual) influences using data-driven process identification. The approach is based on signal-to-noise separation methods and extreme value (EV) modeling of multisite rainfall extremes. The EV models use a semi-automatic parameter learning [1] for model identification across temporal scales. At weather scale, the EV models are combined with a state-based hidden Markov model [2] to represent the spatio-temporal structure of rainfall as persistent weather states. At climatic scale, the EV models are used to decode the drivers leading to the shift of weather patterns. The decoding is performed into a climate-to-weather signal subspace, built via dimension reduction of climate model proxies (e.g. sea surface temperature and atmospheric circulation) We apply the framework to the Western Andean Ridge (WAR) in Ecuador and Peru (0-6°S) using ground data from the second half of the 20th century. We find that the meridional component of winds is what matters for the in-year and inter-annual variability of high rainfall intensities alongside the northern WAR (0-2.5°S). There, low-level southerly winds are found as advection drivers for oceanic moist of the normal-rainy season and weak/moderate the El Niño (EN) type; but, the strong EN type and its unique moisture surplus is locally advected at lowlands in the central WAR. Moreover, the coastal ridges, south of 3°S dampen meridional airflows, leaving local hygrothermal gradients to control the in-year distribution of rainfall extremes and their anomalies. Overall, we show that the framework, which does not make any prior assumption on the explanatory power of the weather

  5. Climate Change Impacts on Flood risk in Urban Areas due to Combined Effects of Extreme Precipitation and Sea Surges

    DEFF Research Database (Denmark)

    Larsen, A. N.; Mikkelsen, Peter Steen; Arnbjerg-Nielsen, Karsten

    Climate change will impact the hydrological cycle greatly and lead to increases in flood hazards due to both pluvial and fluvial floods as well as sea surges in many regions. The impacts of the individual effects are analysed for a catchment in Greater Copenhagen. Based on both the present...

  6. Factors related to outcome of bloodstream infections due to Candida parapsilosis complex.

    Science.gov (United States)

    Barchiesi, Francesco; Orsetti, Elena; Osimani, Patrizia; Catassi, Carlo; Santelli, Fabio; Manso, Esther

    2016-08-09

    Although Candida albicans is the most common cause of fungal blood stream infections (BSIs), infections due to Candida species other than C. albicans are rising. Candida parapsilosis complex has emerged as an important fungal pathogen and became one of the main causes of fungemia in specific geographical areas. We analyzed the factors related to outcome of candidemia due to C. parapsilosis in a single tertiary referral hospital over a five-year period. A retrospective observational study of all cases of candidemia was carried out at a 980-bedded University Hospital in Italy. Data regarding demographic characteristics and clinical risk factors were collected from the patient's medical records. Antifungal susceptibility testing was performed and MIC results were interpreted according to CLSI species-specific clinical breakpoints. Of 270 patients diagnosed with Candida BSIs during the study period, 63 (23 %) were infected with isolates of C. parapsilosis complex which represented the second most frequently isolated yeast after C. albicans. The overall incidence rate was 0.4 episodes/1000 hospital admissions. All the strains were in vitro susceptible to all antifungal agents. The overall crude mortality at 30 days was 27 % (17/63), which was significantly lower than that reported for C. albicans BSIs (42 % [61/146], p = 0.042). Being hospitalized in ICU resulted independently associated with a significant higher risk of mortality (HR 4.625 [CI95% 1.015-21.080], p = 0.048). Conversely, early CVC removal was confirmed to be significantly associated with a lower risk of mortality (HR 0.299 [CI95% 0.102-0.874], p = 0.027). Finally, the type of primary antifungal therapy did not influence the outcome of infection. Candidemia due to C. parapsilosis complex, the second most commonly causative agent of yeast BSIs in our center, is characterized by a non-negligible mortality at 30 days. An early CVC removal is associated with a significant reduced mortality.

  7. Massive hemobilia due to hepatic arteriobiliary fistula during endoscopic retrograde cholangiopancretography: An extremely rare guidewir-related complication

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Jeong Gu; Seo, Young Woo; Hwang, Jae Cheol; Weon, Young Cheol; Kang, Byeong Seong; Bang, Sung Jo; Bang, Min Seo [Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan (Korea, Republic of)

    2015-05-15

    Although endoscopic retrograde cholangiopancreatography (ERCP) is an effective modality for diagnosis and treatment of biliary and pancreatic diseases, the risk for procedure-related complications is high. Hemorrhage is one of major complications of ERCP. Most ERCP-associated bleeding is primarily a complication related to sphincterotomy rather than diagnostic ERCP. We are reporting a case of massive hemobilia due to hepatic arteriobiliary fistula caused by guidewire-associated injury during ERCP, which was successfully treated with transarterial embolization of the hepatic artery.

  8. Ignoring Extreme Opinions in Complex Networks: The Impact of Heterogeneous Thresholds

    CERN Document Server

    Sundaram, Shreyas

    2016-01-01

    We consider a class of opinion dynamics on networks where at each time-step, each node in the network disregards the opinions of a certain number of its most extreme neighbors and updates its own opinion as a weighted average of the remaining opinions. When all nodes disregard the same number of extreme neighbors, previous work has shown that consensus will be reached if and only if the network satisfies certain topological properties. In this paper, we consider the implications of allowing each node to have a personal threshold for the number of extreme neighbors to ignore. We provide graph conditions under which consensus is guaranteed for such dynamics. We then study random networks where each node's threshold is drawn from a certain distribution, and provide conditions on that distribution, together with conditions on the edge formation probability, that guarantee that consensus will be reached asymptotically almost surely.

  9. Second-order complex linear differential equations with special functions or extremal functions as coefficients

    Directory of Open Access Journals (Sweden)

    Xiubi Wu

    2015-05-01

    Full Text Available The classical problem of finding conditions on the entire coefficients A(z and B(z guaranteeing that all nontrivial solutions of $f''+A(zf'+B(zf=0$ are of infinite order is discussed. Two distinct approaches are used. In the first approach the coefficient A(z itself is a solution of a differential equation $w''+P(zw=0$, where P(z is a polynomial. This assumption yields stability on the behavior of A(z via Hille's classical method on asymptotic integration. In this case A(z is a special function of which the Airy integral is one example. The second approach involves extremal functions. It is assumed that either A(z is extremal for Yang's inequality or B(z is extremal for Denjoy's conjecture. A combination of these two approaches is also discussed.

  10. Amputation trends for patients with lower extremity ulcers due to diabetes and peripheral artery disease using statewide data.

    Science.gov (United States)

    Humphries, Misty D; Brunson, Ann; Li, Chin-Shang; Melnikow, Joy; Romano, Patrick S

    2016-12-01

    This study reports all-payer amputation rates using state-based administrative claims data for high-risk patients with lower extremity (LE) ulcers and concomitant peripheral artery disease (PAD), diabetes mellitus (DM), or combination PAD/DM. In addition, we characterize patient factors that affect amputation-free survival. We also attempted to create a measure of a patient's ability to manage chronic diseases or to access appropriate outpatient care for ulcer management by accounting for hospital and emergency department (ED) visits in the preceding 60 days to determine how this also affects amputation-free survival. Patients admitted to nonfederal hospitals, seen in an ED, or treated in an eligible ambulatory surgery center within California from 2005 through 2013 with an International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code for a disease-specific LE ulcer were identified in the California Office of Statewide Health Planning and Development database. All subsequent hospital, ED, and ambulatory surgery center visits and procedures are captured to identify whether a patient underwent major amputation. Yearly amputation rates were determined to analyze trends. Amputation-free survival for the PAD, DM, and PAD/DM groups was determined. Cox modeling was used to evaluate the effect of patient characteristics. There were 219,547 patients identified with an incident LE ulcer throughout the state. Of these, 131,731 were DM associated, 36,193 were PAD associated, and 51,623 were associated with both PAD and DM. From 2005 to 2013, the number of patients with LE ulcers who required inpatient admission, presented to the ED, or had outpatient procedures was stable. However, there was a statistically significant increase in overall disease-associated amputation rates from 5.1 in 2005 to 13.5 in 2013 (P amputation rates from 10 per 100 patients with LE ulcers in 2005 to 28 per 100 patients in 2013 (P amputation-free survival. Within

  11. Low complexity iterative MLSE equalization of M-QAM signals in extremely long rayleigh fading channels

    CSIR Research Space (South Africa)

    Myburgh, HC

    2009-05-01

    Full Text Available long channels. Its computational complexity is linear in the data block length and approximately independent of the channel memory length, whereas conventional equalization algorithms have computational complexity linear in the data block length...

  12. Center of Pressure Displacement of Standing Posture during Rapid Movements Is Reorganised Due to Experimental Lower Extremity Muscle Pain.

    Directory of Open Access Journals (Sweden)

    Shinichiro Shiozawa

    Full Text Available Postural control during rapid movements may be impaired due to musculoskeletal pain. The purpose of this study was to investigate the effect of experimental knee-related muscle pain on the center of pressure (CoP displacement in a reaction time task condition.Nine healthy males performed two reaction time tasks (dominant side shoulder flexion and bilateral heel lift before, during, and after experimental pain induced in the dominant side vastus medialis or the tibialis anterior muscles by hypertonic saline injections. The CoP displacement was extracted from the ipsilateral and contralateral side by two force plates and the net CoP displacement was calculated.Compared with non-painful sessions, tibialis anterior muscle pain during the peak and peak-to-peak displacement for the CoP during anticipatory postural adjustments (APAs of the shoulder task reduced the peak-to-peak displacement of the net CoP in the medial-lateral direction (P<0.05. Tibialis anterior and vastus medialis muscle pain during shoulder flexion task reduced the anterior-posterior peak-to-peak displacement in the ipsilateral side (P<0.05.The central nervous system in healthy individuals was sufficiently robust in maintaining the APA characteristics during pain, although the displacement of net and ipsilateral CoP in the medial-lateral and anterior-posterior directions during unilateral fast shoulder movement was altered.

  13. Evaluation of undesirable deformations in complex, hollow aluminium extrusions due to roll bending

    Science.gov (United States)

    Farstad, Jan Magnus Granheim; Netland, Øyvind; Welo, Torgeir

    2016-10-01

    This paper presents a series of experiments where an aluminium extrusion with a complex, hollow cross-section was formed by roll bending. The extrusion is intended to be used as a rail for a mobile instrumentation platform that requires both straight and bent rail sections in different configurations. In order to develop the system to be highly accurate, precise and functional under all operating conditions, it is vital to know the `nominal' local cross-sectional deformations due to the bending process, and the associated tolerances that can be achieved. The results presented herein are based on nine rail segments that underwent identical bending operations. The differences between the rails were found to be relatively small as seen from a product functionality perspective; thus, the observed deformations are considered acceptable for the application considered. These results will also serve as a reference for future experiments with other bending parameters and methods in the efforts to identify the most technically and commercially viable solution.

  14. Extreme conservation of noncoding DNA near HoxD complex of vertebrates

    Directory of Open Access Journals (Sweden)

    Tripathi Anshuman

    2004-10-01

    Full Text Available Abstract Background Homeotic gene complexes determine the anterior-posterior body axis in animals. The expression pattern and function of hox genes along this axis is colinear with the order in which they are organized in the complex. This 'chromosomal organization and functional correspondence' is conserved in all bilaterians investigated. Genomic sequences covering the HoxD complex from several vertebrate species are now available. This offers a comparative genomics approach to identify conserved regions linked to this complex. Although the molecular basis of 'colinearity' of Hox complexes is not yet understood, it is possible that there are control elements within or in the proximity of these complexes that establish and maintain the expression patterns of hox genes in a coordinated fashion. Results We have compared DNA sequence flanking the HoxD complex of several primate, rodent and fish species. This analysis revealed an unprecedented conservation of non-coding DNA sequences adjacent to the HoxD complex from fish to human. Stretches of hundreds of base pairs in a 7 kb region, upstream of HoxD complex, show 100% conservation across the vertebrate species. Using PCR primers from the human sequence, these conserved regions could be amplified from other vertebrate species, including other mammals, birds, reptiles, amphibians and fish. Our analysis of these sequences also indicates that starting from the conserved core regions, more sequences have been added on and maintained during evolution from fish to human. Conclusion Such a high degree of conservation in the core regions of this 7 kb DNA, where no variation occurred during ~500 million years of evolution, suggests critical function for these sequences. We suggest that such sequences are likely to provide molecular handle to gain insight into the evolution and mechanism of regulation of associated gene complexes.

  15. Complex Systems Theory to understand extremely low frequency magnetic fields interaction with immune cells

    Science.gov (United States)

    Vázquez-Coutiño, G. A.; Serrano-Luna, G.; Cañedo-Dorantes, L.; Godina-Nava, J. J.; Rodríguez-Segura, M. A.

    2003-09-01

    Well-documented studies about the interaction of extremely low frequency electromagnetic fields (ELF) with lymphocytes provide elements for the development of non-linear theoretical models. The Eichwald-Kaiser model of calcium oscillations was tested with a rectified cosine function at a frequency of 120 Hz. A change in dynamical behavior of calcium oscillations, from periodic in the normal case (without perturbation, what corresponds to a limit cycle) to the existence of very small micro-oscillations and a strange attractor in the perturbed case was found. It is concluded that the ELF configuration used in this model, alters the dynamical behavior of calcium oscillations in lymphocytes.

  16. Bunched black (and grouped grey) swans: Dissipative and non-dissipative models of correlated extreme fluctuations in complex geosystems

    Science.gov (United States)

    Watkins, N. W.

    2013-01-01

    I review the hierarchy of approaches to complex systems, focusing particularly on stochastic equations. I discuss how the main models advocated by the late Benoit Mandelbrot fit into this classification, and how they continue to contribute to cross-disciplinary approaches to the increasingly important problems of correlated extreme events and unresolved scales. The ideas have broad importance, with applications ranging across science areas as diverse as the heavy tailed distributions of intense rainfall in hydrology, after which Mandelbrot named the "Noah effect"; the problem of correlated runs of dry summers in climate, after which the "Joseph effect" was named; and the intermittent, bursty, volatility seen in finance and fluid turbulence.

  17. Cellular immune responses to ESAT-6 discriminate between patients with pulmonary disease due to Mycobacterium avium complex and those with pulmonary disease due to Mycobacterium tuberculosis

    DEFF Research Database (Denmark)

    Lein, A D; von Reyn, C F; Ravn, P;

    1999-01-01

    ESAT-6 (for 6-kDa early secreted antigenic target) is a secreted antigen found almost exclusively in organisms of the Mycobacterium tuberculosis complex. We compared in vitro gamma interferon (IFN-gamma) responses by peripheral blood mononuclear cells to this antigen in patients with pulmonary...... disease due to either Mycobacterium avium complex (MAC) or Mycobacterium tuberculosis with those in healthy, skin test-negative, control subjects. Significant IFN-gamma responses to ESAT-6 were detected in 16 (59%) of 27 M. tuberculosis pulmonary disease patients, 0 (0%) of 8 MAC disease patients, and 0...... (0%) of 8 controls. Significant IFN-gamma responses to M. tuberculosis purified protein derivative were detected in 23 (85%) of 27 M. tuberculosis disease patients, 2 (25%) of 8 MAC disease patients, and 5 (63%) of 8 healthy controls. M. avium sensitin was recognized in 24 (89%) of 27 M. tuberculosis...

  18. Complex magnetic susceptibility setup for spectroscopy in the extremely low-frequency range

    NARCIS (Netherlands)

    Kuipers, B.W.M.; Bakelaar, I.A.; Klokkenburg, M.; Erne, B.H.

    2008-01-01

    A sensitive balanced differential transformer was built to measure complex initial parallel magnetic susceptibility spectra in the 0.01–1000 Hz range. The alternating magnetic field can be chosen sufficiently weak that the magnetic structure of the samples is only slightly perturbed and the low freq

  19. Modelling the increased frequency of extreme sea levels in the Ganges-Brahmaputra-Meghna delta due to sea level rise and other effects of climate change.

    Science.gov (United States)

    Kay, S; Caesar, J; Wolf, J; Bricheno, L; Nicholls, R J; Saiful Islam, A K M; Haque, A; Pardaens, A; Lowe, J A

    2015-07-01

    Coastal flooding due to storm surge and high tides is a serious risk for inhabitants of the Ganges-Brahmaputra-Meghna (GBM) delta, as much of the land is close to sea level. Climate change could lead to large areas of land being subject to increased flooding, salinization and ultimate abandonment in West Bengal, India, and Bangladesh. IPCC 5th assessment modelling of sea level rise and estimates of subsidence rates from the EU IMPACT2C project suggest that sea level in the GBM delta region may rise by 0.63 to 0.88 m by 2090, with some studies suggesting this could be up to 0.5 m higher if potential substantial melting of the West Antarctic ice sheet is included. These sea level rise scenarios lead to increased frequency of high water coastal events. Any effect of climate change on the frequency and severity of storms can also have an effect on extreme sea levels. A shelf-sea model of the Bay of Bengal has been used to investigate how the combined effect of sea level rise and changes in other environmental conditions under climate change may alter the frequency of extreme sea level events for the period 1971 to 2099. The model was forced using atmospheric and oceanic boundary conditions derived from climate model projections and the future scenario increase in sea level was applied at its ocean boundary. The model results show an increased likelihood of extreme sea level events through the 21st century, with the frequency of events increasing greatly in the second half of the century: water levels that occurred at decadal time intervals under present-day model conditions occurred in most years by the middle of the 21st century and 3-15 times per year by 2100. The heights of the most extreme events tend to increase more in the first half of the century than the second. The modelled scenarios provide a case study of how sea level rise and other effects of climate change may combine to produce a greatly increased threat to life and property in the GBM delta by the end

  20. Resting oxygen consumption and in vivo ADP are increased in myopathy due to complex I deficiency

    NARCIS (Netherlands)

    Roef, MJ; Reijngoud, DJ; Jeneson, JAL; Berger, R; de Meer, K

    2002-01-01

    Background: Patients with isolated complex I deficiency (CID) in skeletal muscle mitochondria often present with exercise intolerance as their major clinical symptom. Objective: To study the in vivo bioenergetics in patients with complex I deficiency in skeletal muscle mitochondria. Methods: In vivo

  1. Study of complex properties of binary system of ethanol-methanol at extreme concentrations

    CERN Document Server

    Nilavarasi, K; Madhurima, V

    2016-01-01

    At low concentrations of methanol in ethanol-methanol binary system, the molecular interactions are seen to be uniquely complex. It is observed that the ethanol aggregates are not strictly hydrogen-bonded complexes; dispersion forces also play a dominant role in the self- association of ethanol molecules. On the addition of small amount of methanol to ethanol, the dipolar association of ethanol is destroyed. The repulsive forces between the two moieties dominate the behavior of the binary system at lower concentration of methanol. At higher concentration of methanol (> 30%), the strength and extent (number) of formation of hydrogen bonds between ethanol and methanol increases. The geometry of molecular structure at high concentration favors the fitting of component molecules with each other. Intermolecular interactions in the ethanol-methanol binary system over the entire concentration range were investigated in detail using broadband dielectric spectroscopy, FTIR, surface tension and refractive index studies...

  2. RPGR-containing protein complexes in syndromic and non-syndromic retinal degeneration due to ciliary dysfunction

    Indian Academy of Sciences (India)

    Carlos A. Murga-Zamalloa; Anand Swaroop; Hemant Khanna

    2009-12-01

    Dysfunction of primary cilia due to mutations in cilia-centrosomal proteins is associated with pleiotropic disorders. The primary (or sensory) cilium of photoreceptors mediates polarized trafficking of proteins for efficient phototransduction. Retinitis pigmentosa GTPase regulator (RPGR) is a cilia-centrosomal protein mutated in >70% of X-linked RP cases and 10%–20% of simplex RP males. Accumulating evidence indicates that RPGR may facilitate the orchestration of multiple ciliary protein complexes. Disruption of these complexes due to mutations in component proteins is an underlying cause of associated photoreceptor degeneration. Here, we highlight the recent developments in understanding the mechanism of cilia-dependent photoreceptor degeneration due to mutations in RPGR and RPGR-interacting proteins in severe genetic diseases, including retinitis pigmentosa, Leber congenital amaurosis (LCA), Joubert syndrome, and Senior–Loken syndrome, and explore the physiological relevance of photoreceptor ciliary protein complexes.

  3. An archaeal tRNA-synthetase complex that enhances aminoacylation under extreme conditions

    DEFF Research Database (Denmark)

    Godinic-Mikulcic, Vlatka; Jaric, Jelena; Hausmann, Corinne D;

    2011-01-01

    Aminoacyl-tRNA synthetases (aaRSs) play an integral role in protein synthesis, functioning to attach the correct amino acid with its cognate tRNA molecule. AaRSs are known to associate into higher-order multi-aminoacyl-tRNA synthetase complexes (MSC) involved in archaeal and eukaryotic translation...... in the catalytic efficiency of serine attachment to tRNA, but had no effect on the activity of MtArgRS. Further, the most pronounced improvements in the aminoacylation activity of MtSerRS induced by MtArgRS were observed under conditions of elevated temperature and osmolarity. These data indicate that formation...

  4. Complex III deficiency due to an in-frame MT-CYB deletion presenting as ketotic hypoglycemia and lactic acidosis

    Directory of Open Access Journals (Sweden)

    Mari Mori

    2015-09-01

    Full Text Available Complex III deficiency due to a MT-CYB mutation has been reported in patients with myopathy. Here, we describe a 15-year-old boy who presented with metabolic acidosis, ketotic hypoglycemia and carnitine deficiency. Electron transport chain analysis and mitochondrial DNA sequencing on muscle tissue lead to the eventual diagnosis of complex III deficiency. This case demonstrates the critical role of muscle biopsies in a myopathy work-up, and the clinical efficacy of supplement therapy.

  5. Extreme evolutionary disparities seen in positive selection across seven complex diseases.

    Directory of Open Access Journals (Sweden)

    Erik Corona

    Full Text Available Positive selection is known to occur when the environment that an organism inhabits is suddenly altered, as is the case across recent human history. Genome-wide association studies (GWASs have successfully illuminated disease-associated variation. However, whether human evolution is heading towards or away from disease susceptibility in general remains an open question. The genetic-basis of common complex disease may partially be caused by positive selection events, which simultaneously increased fitness and susceptibility to disease. We analyze seven diseases studied by the Wellcome Trust Case Control Consortium to compare evidence for selection at every locus associated with disease. We take a large set of the most strongly associated SNPs in each GWA study in order to capture more hidden associations at the cost of introducing false positives into our analysis. We then search for signs of positive selection in this inclusive set of SNPs. There are striking differences between the seven studied diseases. We find alleles increasing susceptibility to Type 1 Diabetes (T1D, Rheumatoid Arthritis (RA, and Crohn's Disease (CD underwent recent positive selection. There is more selection in alleles increasing, rather than decreasing, susceptibility to T1D. In the 80 SNPs most associated with T1D (p-value <7.01 x 10(-5 showing strong signs of positive selection, 58 alleles associated with disease susceptibility show signs of positive selection, while only 22 associated with disease protection show signs of positive selection. Alleles increasing susceptibility to RA are under selection as well. In contrast, selection in SNPs associated with CD favors protective alleles. These results inform the current understanding of disease etiology, shed light on potential benefits associated with the genetic-basis of disease, and aid in the efforts to identify causal genetic factors underlying complex disease.

  6. Forward Modeling of Gravity, Gravity Gradients,and Magnetic Anomalies due to Complex Bodies

    Institute of Scientific and Technical Information of China (English)

    Luo Yao; Yao Changli

    2007-01-01

    On the basis of the results of improved analytical expression of computation of gravity anomalies due to a homogeneous polyhedral body composed of polygonal facets, and applying the forward theory with the coordinate transformation of vectors and tensors, we deduced both the analytical expressions for gravity gradient tensors and for magnetic anomalies of a polygon, and obtained new analytical expressions for computing vertical gradients of gravity anomalies and vertical component of magnetic anomalies caused by a polyhedral body. And also we developed explicitly the complete unified expressions for the calculation of gravity anomalies, gravity gradient, and magnetic anomalies due to the homogeneous polyhedron. Furthermore, we deduced new analytical expressions for computing vertical gradients of gravity anomalies due to a finite rectangular prism by applying the newly obtained expressions for gravity gradient tensors due to a polyhedral target body. Comparison with forward calculation of models shows the correctness of these new expressions. It will reduce forward calculation time of gravity-magnetic anomalies and improve computational efficiency by applying our unified expressions for joint forward modeling of gravity-magnetic anomalies due to homogeneous polyhedral bodies.

  7. Lactate disposal via gluconeogenesis is increased during exercise in patients with mitochondrial myopathy due to complex I deficiency

    NARCIS (Netherlands)

    Roef, MJ; Kalhan, SC; Reijngoud, DJ; De Meer, K; Berger, Ruud

    2002-01-01

    This study evaluated lactate disposal via gluconeogenesis as well as effects of FFA availability on gluconeogenesis via pyruvate (GNG(PYR)) in patients with mitochondrial myopathy due to complex I deficiency (CID). The rates of GNG(PYR) were measured in three CID patients and six healthy controls at

  8. Mitochondrial Oxidative Stress due to Complex I Dysfunction Promotes Fibroblast Activation and Melanoma Cell Invasiveness

    Directory of Open Access Journals (Sweden)

    Maria Letizia Taddei

    2012-01-01

    Full Text Available Increased ROS (cellular reactive oxygen species are characteristic of both fibrosis and tumour development. ROS induce the trans-differentiation to myofibroblasts, the activated form of fibroblasts able to promote cancer progression. Here, we report the role of ROS produced in response to dysfunctions of mitochondrial complex I, in fibroblast activation and in tumour progression. We studied human fibroblasts with mitochondrial dysfunctions of complex I, leading to hyperproduction of ROS. We demonstrated that ROS level produced by the mutated fibroblasts correlates with their activation. The increase of ROS in these cells provides a greater ability to remodel the extracellular matrix leading to an increased motility and invasiveness. Furthermore, we evidentiated that in hypoxic conditions these fibroblasts cause HIF-1α stabilization and promote a proinvasive phenotype of human melanoma cells through secretion of cytokines. These data suggest a possible role of deregulated mitochondrial ROS production in fibrosis evolution as well as in cancer progression and invasion.

  9. Features of electromagnetic waves in a complex plasma due to surface plasmon resonances on macroparticles

    CERN Document Server

    Vladimirov, S V

    2015-01-01

    The dielectric properties of complex plasma containing either metal or dielectric spherical inclusions (macroparticles, dust) are investigated. We focus on surface plasmon resonances on the macroparticle surfaces and their effect on electromagnetic wave propagation. It is demonstrated that the presence of surface plasmon oscillations significantly modifies plasma electromagnetic properties by resonances and cutoffs in the effective permittivity. This leads to related branches of electromagnetic waves and to the wave band gaps. The results are discussed in the context of dusty plasma experiments.

  10. Display of the complex degree of coherence due to quasi-monochromatic spatially incoherent sources.

    Science.gov (United States)

    Michalski, M; Sicre, E E; Rabal, H J

    1985-12-01

    A method for displaying the complex degree of coherence (CDC) of a quasi-monochromatic spatially incoherent source is proposed. The phase of the CDC is encoded in a method similar to that used in interferometric imaging with incoherent light. The method is based on Fourier analysis of the speckle pattern that appears when a diffuser is illuminated with the partially coherent field whose CDC is to be displayed. In addition, an intensity pattern that resembles the spatial distribution of the incoherent source can also be obtained.

  11. Modified photoreactivity due to mixed crystal formation. I. Three mixed crystals between isostructural cobaloxime complexes.

    Science.gov (United States)

    Vithana, Champika; Uekusa, Hidehiro; Sekine, Akiko; Ohashi, Yuji

    2002-04-01

    Three crystals of 2-cyanoethyl cobaloxime complexes with 3-chloropyridine, 3-bromopyridine and 3-methylpyridine as axial base ligands are isostructural to one another. Three mixed crystals were formed between the pairs: (3-bromopyridine)(2-cyanoethyl)cobaloxime-(2-cyanoethyl)(3-methylpyridine)cobaloxime(0.45/0.55);(3-chloropyridine)(2-cyanoethyl)cobaloxime-(2-cyanoethyl)(3bromopyridine)cobaloxime (0.61/0.39); (3-chloropyridine)(2-cyanoethyl)cobaloxime-(2-cyanoethyl)(3-methylpyridine)cobaloxime (0.44/0.56). The X-ray crystal structure analysis revealed that the mixed compounds are also isostructural to the component crystals. It was found from the change in IR spectra that the 2-cyanoethyl groups in the three mixed crystals isomerized to 1-cyanoethyl groups on exposure to a xenon lamp, as observed for the 2-cyanoethyl groups in the component crystals. Rate constants for the three mixed and three component crystals, measured under the same conditions, are approximately the same, as the reaction cavities for the 2-cyanoethyl groups in the six crystals have almost the same size. For the mixed crystal between 3-chloropyridine and 3-methylpyridine complexes, the isomerization proceeded with retention of the single-crystal form. The conformation and configuration of the 1-cyanoethyl group that was produced were well explained by the shape of the reaction cavity before irradiation.

  12. [Autologous transfusion of UV-irradiated blood in the complex treatment of children with dysplasia of deep veins of the extremities].

    Science.gov (United States)

    Levanovich, V V; Kupatadze, D D; Endzhibadze, Iu G; Nabokov, V V; Mazurova, E V; Ivanov, A P; Chirovich, M

    1991-02-01

    Under examination there were 12 patients aged from 5 till 14 years. An investigation of hemostatic potential of blood in the diseased extremity and peripheral blood was performed. A mosaic character of blood coagulative alterations in this category of patients was detected. Autotransfusion of UV-irradiated blood is a pathogenetically grounded and accessible method of correction of hemocoagulation and may be included in the complex treatment of patients with dysplasia of the profound veins of lower extremities.

  13. Complex behavior of internal collapse due to self-generated radial electric field

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Taro; Tokuda, Shinji; Kishimoto, Yasuaki; Takizuka, Tomonori [Japan Atomic Energy Research Inst., Naka, Ibaraki (Japan). Naka Fusion Research Establishment; Naitou, Hiroshi [Department of Electical and Electronic Engineering, Yamaguchi University, Ube, Yamaguchi (Japan)

    2000-07-01

    The density gradient effect is taken into account in the gyro-kinetic nonlinear simulation of the kinetic m=1 internal kink mode to clarify the nonlinear behavior of the internal collapse. Even when the density gradient is not so large enough to change the process of the full reconnection, the later process is changed considerably due to the self-generated radial electric field. The nonlinear growth of the 0/0 mode after the internal collapse violates the symmetrical flow of the parallel current, restricting the secondary reconnection. (author)

  14. Probability assessment for the incidence of extreme events due to the climatic change. Focus Germany; Berechnung der Wahrscheinlichkeiten fuer das Eintreten von Extremereignissen durch Klimaaenderungen. Schwerpunkt Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Jonas, Martin; Staeger, Tim; Schoenwiese, Christian-Dietrich [Frankfurt Univ. (Germany). Inst. fuer Atmosphaere und Umwelt, Arbeitsgruppe Klimaforschung

    2005-08-15

    The study on the probability of occurrence of extreme weather events in Germany is based on compiled data covering ground-level temperature, precipitation and wind during the time period 1901 to 2000. The data processing approach is based on two methodologies: a time-gliding extreme value analysis and a structure-oriented time-series analysis. The results show a significant increase of very hot months and at the same time a decrease of extreme cold months within the 20th century. In the time period after 1951 the probability of very high daily maximum temperatures increased for all seasons. Concerning the precipitation the increase of extreme values and higher variabilities are observed for the winter period. The results concerning the wind are not so clear. Summarizing the extreme behavior of temperature and precipitation has shown strong variations during the last century.

  15. Estimating SI violation in CMB due to non-circular beam and complex scan in minutes

    CERN Document Server

    Pant, Nidhi; Rotti, Aditya; Mitra, Sanjit; Souradeep, Tarun

    2015-01-01

    Mild, unavoidable deviations from circular-symmetry of instrumental beams along with scan strategy can give rise to measurable Statistical Isotropy (SI) violation in Cosmic Microwave Background (CMB) experiments. If not accounted properly, this spurious signal can complicate the extraction of other SI violation signals (if any) in the data. However, estimation of this effect through exact numerical simulation is computationally intensive and time consuming. A generalized analytical formalism not only provides a quick way of estimating this signal, but also gives a detailed understanding connecting the leading beam anisotropy components to a measurable BipoSH characterisation of SI violation. In this paper, we provide an approximate generic analytical method for estimating the SI violation generated due to a non-circular (NC) beam and arbitrary scan strategy, in terms of the Bipolar Spherical Harmonic (BipoSH) spectra. Our analytical method can predict almost all the features introduced by a NC beam in a compl...

  16. CCT2 Mutations Evoke Leber Congenital Amaurosis due to Chaperone Complex Instability

    Science.gov (United States)

    Minegishi, Yuriko; Sheng, XunLun; Yoshitake, Kazutoshi; Sergeev, Yuri; Iejima, Daisuke; Shibagaki, Yoshio; Monma, Norikazu; Ikeo, Kazuho; Furuno, Masaaki; Zhuang, Wenjun; Liu, Yani; Rong, Weining; Hattori, Seisuke; Iwata, Takeshi

    2016-01-01

    Leber congenital amaurosis (LCA) is a hereditary early-onset retinal dystrophy that is accompanied by severe macular degeneration. In this study, novel compound heterozygous mutations were identified as LCA-causative in chaperonin-containing TCP-1, subunit 2 (CCT2), a gene that encodes the molecular chaperone protein, CCTβ. The zebrafish mutants of CCTβ are known to exhibit the eye phenotype while its mutation and association with human disease have been unknown. The CCT proteins (CCT α-θ) forms ring complex for its chaperon function. The LCA mutants of CCTβ, T400P and R516H, are biochemically instable and the affinity for the adjacent subunit, CCTγ, was affected distinctly in both mutants. The patient-derived induced pluripotent stem cells (iPSCs), carrying these CCTβ mutants, were less proliferative than the control iPSCs. Decreased proliferation under Cct2 knockdown in 661W cells was significantly rescued by wild-type CCTβ expression. However, the expression of T400P and R516H didn’t exhibit the significant effect. In mouse retina, both CCTβ and CCTγ are expressed in the retinal ganglion cells and connecting cilium of photoreceptor cells. The Cct2 knockdown decreased its major client protein, transducing β1 (Gβ1). Here we report the novel LCA mutations in CCTβ and the impact of chaperon disability by these mutations in cellular biology. PMID:27645772

  17. ATR-16 due to a de novo complex rearrangement of chromosome 16.

    Science.gov (United States)

    Gallego, Marta S; Zelaya, Gabriela; Feliu, Aurora S; Rossetti, Liliana; Shaffer, Lisa G; Bailey, Kristen A; Bacino, Carlos A; Barreiro, Cristina Z

    2005-01-01

    We describe a child with ATR-16 [alpha-thalassemia (thal)/mental retardation], who was referred for genetic evaluation because of minor anomalies and developmental delay. Cytogenetic analysis demonstrated a de novo complex rearrangement of chromosome 16. Fluorescence in situ hybridization (FISH) analysis, using chromosome 16 subtelomeric probes, showed that this patient had a deletion of the distal short arm of chromosome 16 that contains the alpha-globin genes and a duplication of 16q. Analysis of the alpha-globin locus by Southern blot showed a half normal dose of the alpha-globin gene. Microsatellite marker studies revealed that the duplicated 16q region was maternal in origin. Hematological studies revealed anemia, hypochromia and occasional cells with Hb H inclusion bodies. A hematological screening for alpha-thal should be considered in patients with mild developmental delay and a suggestive phenotype of ATR-16 with microcytic hypochromic anemia and normal iron status. The stellate pattern of the iris, a new finding in our patient, may contribute to a better clinical delineation of both syndromes, ATR-16 and/or duplication of 16qter.

  18. Physiotherapy and a Homeopathic Complex for Chronic Low Back Pain Due to Osteoarthritis: A Randomized, Controlled Pilot Study

    OpenAIRE

    Pellow, Janice

    2016-01-01

    Abstract:Context: Osteoarthritis (OA) is a common cause of chronic low back pain (CLBP) and can be managed with the use of drug therapy and physiotherapy. Homeopathic remedies may assist in the management of OA; however, research that supports their effectiveness is limited. Objectives: The study aimed to investigate the efficacy of a homeopathic complex in combination with physiotherapy in the treatment of CLBP due to OA. Design: The study was a six-week, randomized, double-blind, placebo-co...

  19. INTERVENTIONS TO MANAGE RESIDUAL LIMB ULCERATION DUE TO PROSTHETIC USE IN INDIVIDUALS WITH LOWER EXTREMITY AMPUTATION: A SYSTEMATIC REVIEW OF THE LITERATURE.

    Science.gov (United States)

    Highsmith, M Jason; Kahle, Jason T; Klenow, Tyler D; Andrews, Casey R; Lewis, Katherine L; Bradley, Rachel C; Ward, Jessica M; Orriola, John J; Highsmith, James T

    2016-09-01

    Patients with lower extremity amputation (LEA) experience 65% more dermatologic issues than non-amputees, and skin problems are experienced by ≈75% of LEA patients who use prostheses. Continuously referring LEA patients to a dermatologist for every stump related skin condition may be impractical. Thus, physical rehabilitation professionals should be prepared to recognize and manage common non-emergent skin conditions in this population. The purpose of this study was to determine the quantity, quality, and strength of available evidence supporting treatment methods for prosthesis-related residual limb (RL) ulcers. Systematic literature review with evidence grading and synthesis of empirical evidence statements (EES) was employed. Three EESs were formulated describing ulcer etiology, conditions in which prosthetic continuance is practical, circumstances likely requiring prosthetic discontinuance, and the consideration of additional medical or surgical interventions. Continued prosthetic use is a viable option to manage minor or early-stage ulcerated residual limbs in compliant patients lacking multiple comorbidities. Prosthetic discontinuance is also a viable method of residual limb ulcer healing and may be favored in the presence of severe acute ulcerations, chronic heavy smoking, intractable pain, rapid volume and weight change, history of chronic ulceration, systemic infections, or advanced dysvascular etiology. Surgery or other interventions may also be necessary in such cases to achieve restored prosthetic ambulation. A short bout of prosthetic discontinuance with a staged re-introduction plan is another viable option that may be warranted in patients with ulceration due to poor RL volume management. High-quality prospective research with larger samples is needed to determine the most appropriate course of treatment when a person with LEA develops an RL ulcer that is associated with prosthetic use.

  20. Complex neurological symptoms in bilateral thalamic stroke due to Percheron artery occlusion

    Science.gov (United States)

    Caruso, Paola; Manganotti, Paolo; Moretti, Rita

    2017-01-01

    The artery of Percheron is a rare anatomical variant where a single thalamic perforating artery arises from the proximal posterior cerebral artery (P1 segment) between the basilar artery and the posterior communicating artery and supplies the rostral mesencephalon and both paramedian territories of the thalami. Almost one-third of human brains present this variant. Occlusion of the artery of Percheron mostly results in a bilateral medial thalamic infarction, which usually manifests with altered consciousness (including coma), vertical gaze paresis, and cognitive disturbance. The presentation is similar to the “top of the basilar syndrome”, and early recognition should be prompted. We describe the case of a young female with this vessel variant who experienced a bilateral thalamic stroke. Magnetic resonance angiography demonstrated bilateral thalamic infarcts and a truncated artery of Percheron. Occlusion of the vessel was presumably due to embolism from a patent foramen ovale. Thrombolysis was performed, with incomplete symptom remission, cognitive impairment, and persistence of speech disorders. Early recognition and treatment of posterior circulation strokes is mandatory, and further investigation for underlying stroke etiologies is needed. PMID:28053539

  1. Integrating seasonal optical and thermal infrared spectra to characterize urban impervious surfaces with extreme spectral complexity: a Shanghai case study

    Science.gov (United States)

    Wang, Wei; Yao, Xinfeng; Ji, Minhe

    2016-01-01

    Despite recent rapid advancement in remote sensing technology, accurate mapping of the urban landscape in China still faces a great challenge due to unusually high spectral complexity in many big cities. Much of this complication comes from severe spectral confusion of impervious surfaces with polluted water bodies and bright bare soils. This paper proposes a two-step land cover decomposition method, which combines optical and thermal spectra from different seasons to cope with the issue of urban spectral complexity. First, a linear spectral mixture analysis was employed to generate fraction images for three preliminary endmembers (high albedo, low albedo, and vegetation). Seasonal change analysis on land surface temperature induced from thermal infrared spectra and coarse component fractions obtained from the first step was then used to reduce the confusion between impervious surfaces and nonimpervious materials. This method was tested with two-date Landsat multispectral data in Shanghai, one of China's megacities. The results showed that the method was capable of consistently estimating impervious surfaces in highly complex urban environments with an accuracy of R2 greater than 0.70 and both root mean square error and mean average error less than 0.20 for all test sites. This strategy seemed very promising for landscape mapping of complex urban areas.

  2. Effectiveness of Working Memory Training among Subjects Currently on Sick Leave Due to Complex Symptoms

    Science.gov (United States)

    Aasvik, Julie K.; Woodhouse, Astrid; Stiles, Tore C.; Jacobsen, Henrik B.; Landmark, Tormod; Glette, Mari; Borchgrevink, Petter C.; Landrø, Nils I.

    2017-01-01

    Introduction: The current study examined if adaptive working memory training (Cogmed QM) has the potential to improve inhibitory control, working memory capacity, and perceptions of memory functioning in a group of patients currently on sick leave due to symptoms of pain, insomnia, fatigue, depression and anxiety. Participants who were referred to a vocational rehabilitation center volunteered to take part in the study. Methods: Participants were randomly assigned to either a training condition (N = 25) or a control condition (N = 29). Participants in the training condition received working memory training in addition to the clinical intervention offered as part of the rehabilitation program, while participants in the control condition received treatment as usual i.e., the rehabilitation program only. Inhibitory control was measured by The Stop Signal Task, working memory was assessed by the Spatial Working Memory Test, while perceptions of memory functioning were assessed by The Everyday Memory Questionnaire-Revised. Results: Participants in the training group showed a significant improvement on the post-tests of inhibitory control when compared with the comparison group (p = 0.025). The groups did not differ on the post-tests of working memory. Both groups reported less memory problems at post-testing, but there was no sizeable difference between the two groups. Conclusions: Results indicate that working memory training does not improve general working memory capacity per se. Nor does it seem to give any added effects in terms of targeting and improving self-perceived memory functioning. Results do, however, provide evidence to suggest that inhibitory control is accessible and susceptible to modification by adaptive working memory training. PMID:28111555

  3. Online coupling of high-resolution chromatography with extreme UV photon activation tandem mass spectrometry: Application to the structural investigation of complex glycans by dissociative photoionization

    Energy Technology Data Exchange (ETDEWEB)

    Ropartz, David, E-mail: David.Ropartz@nantes.inra.fr [INRA, UR1268 Biopolymers Interactions Assemblies F-44316 Nantes (France); Giuliani, Alexandre [Synchrotron SOLEIL, L' Orme des Merisiers, F-91190 Gif-sur-Yvette (France); UAR 1008 CEPIA, INRA, F-44316 Nantes (France); Fanuel, Mathieu [INRA, UR1268 Biopolymers Interactions Assemblies F-44316 Nantes (France); Hervé, Cécile; Czjzek, Mirjam [Sorbonne Universités, Université Pierre et Marie Curie, Paris VI, CNRS, Integrative Biology of Marine Models, UMR 8227, Station Biologique, Place George Teissier, F29688 Roscoff Cedex (France); Rogniaux, Hélène [INRA, UR1268 Biopolymers Interactions Assemblies F-44316 Nantes (France)

    2016-08-24

    The activation of ions by extreme-energy photons (XUV) produced by a synchrotron radiation beamline is a powerful method for characterizing complex glycans using tandem mass spectrometry (MS). As previously described, this activation method leads to rich fragmentation spectra with many structurally valuable cross-ring cleavages while maintaining labile modifications on the glycan structures. However, until now, the tandem MS event was too long to be compatible with liquid chromatography elution times. In this work, the duty cycle of the activation and detection of fragments was shortened, and the background signal on the spectra was drastically reduced. Both improvements allowed, for the first time, the successful coupling of a UHPLC system to XUV-activated tandem MS. The approach was used to characterize a complex mixture of oligo-porphyrans, which are a class of highly sulfated oligosaccharides, in a fully automated way. Due to an enhanced dynamic range and an increased sensitivity, some hypothetical structures of low abundance have been unequivocally confirmed in this study and others have been revised. Some previously undescribed species of oligo-porphyrans that exhibit lateral branching have been fully resolved. This work contributes to the scarce knowledge of the structure of porphyrans in red algae and pushes the current capacities of XUV-activation tandem MS by demonstrating the possibility of a direct coupling with UHPLC. This study will considerably broaden the applicability and practicality of this method in many fields of analytical biology. - Highlights: • For the first time, XUV photon activation tandem MS was coupled to UHPLC. • The approach was used to characterize a complex mixture of biomolecules. • The MSMS duty cycle was compatible with elution times of UHPLC without compromised. • Minor species were characterized with an enhanced sensitivity and dynamic range. • These results broaden the application of the technique in many field of

  4. Rheological principles of development hetero-modulus and hetero-viscous complex materials with extreme dynamic strength

    Science.gov (United States)

    Gömze, L. A.; Gömze, L. N.

    2017-02-01

    Materials with different crystalline and morphological compositions have different chemical, physical, mechanical and rheological properties, including wear protection, melting temperature, module of elasticity and viscosity. Examining the material structures and behaviors of differentceramic bodies and CMCs under high speed collisions in several years the authors have understood the advantages of hetero-modulus and hetero-viscous complex material systems to absorb and dissipate the kinetic energy of objects during high speed collisions. Applying the rheo-mechanical principles the authors successfully developed a new family of hetero-modulus and hetero-viscous alumina matrix composite materials with extreme mechanical properties including dynamic strength. These new corundum-matrix composite materials reinforced with Si2ON 2, Si3N4 , SiAlON and AlN submicron and nanoparticles have excellent dynamic strength during collisions with high density metallic bodies with speeds about 1000 m/sec or more. At the same time in the alumina matrix composites can be observed a phase transformation of submicron and nanoparticles of alpha and beta silicone-nitride crystals into cubicc-Si3N4 diamond-like particles can be observed, when the high speed collision processes are taken place in vacuum or oxygen-free atmosphere. Using the rheological principles and the energy engorgement by fractures, heating and melting of components the authors successfully developed several new hetero-modulus, hetero-viscous and hetero-plastic complex materials. These materials generally are based on ceramic matrixes and components having different melting temperatures and modules of elasticity from low values like carbon and light metals (Mg, Al, Ti, Si) up to very high values like boride, nitride and carbide ceramics. Analytical methods applied in this research were scanning electron microscopy, X-ray diffractions and energy dispersive spectrometry. Digital image analysis was applied to microscopy

  5. Extreme pollution of soils by emissions of the copper-nickel industrial complex in the Kola Peninsula

    Science.gov (United States)

    Kashulina, G. M.

    2017-07-01

    The distribution of the total Ni, Cu, Co, Cd, Pb, and Zn contents was studied in the soil profiles of six catenas in the zone subjected to emissions of the copper-nickel industrial complex, which is the largest source of SO2 and heavy metals in northern Europe. The results show that, at present, the concentrations of Ni and Cu in the upper organic soil horizons in the impact zone reach extreme levels of 9000 and 6000 mg/kg, respectively. Under conditions of the long-term intense multi-element industrial emissions, the modern levels of the accumulation of polluting substances in soils greatly depend on the indirect factors, such as the degree of the technogenic degradation of soils with the loss of a significant part of soil organic matter, the reaching of threshold saturation of the topsoil with polluting metals, and competitive relationships between chemical elements. The state of the ecosystems in the impact zone varied greatly and did not always agree with the contents of the main metals-pollutants in the soils. The moisture conditions determined by the landscape position affected significantly the resistance of the ecosystems to emissions.

  6. Performing Complex Tasks by Users With Upper-Extremity Disabilities Using a 6-DOF Robotic Arm: A Study.

    Science.gov (United States)

    Al-Halimi, Reem K; Moussa, Medhat

    2017-06-01

    In this paper, we report on the results of a study that was conducted to examine how users suffering from severe upper-extremity disabilities can control a 6 degrees-of-freedom (DOF) robotics arm to complete complex activities of daily living. The focus of the study is not on assessing the robot arm but on examining the human-robot interaction patterns. Three participants were recruited. Each participant was asked to perform three tasks: eating three pieces of pre-cut bread from a plate, drinking three sips of soup from a bowl, and opening a right-handed door with lever handle. Each of these tasks was repeated three times. The arm was mounted on the participant's wheelchair, and the participants were free to move the arm as they wish to complete these tasks. Each task consisted of a sequence of modes where a mode is defined as arm movement in one DOF. Results show that participants used a total of 938 mode movements with an average of 75.5 (std 10.2) modes for the eating task, 70 (std 8.8) modes for the soup task, and 18.7 (std 4.5) modes for the door opening task. Tasks were then segmented into smaller subtasks. It was found that there are patterns of usage per participant and per subtask. These patterns can potentially allow a robot to learn from user's demonstration what is the task being executed and by whom and respond accordingly to reduce user effort.

  7. Assessing and modeling sediment mobility in estuarine and coastal settings due to extreme climate events from natural short-lived isotope distribution

    Science.gov (United States)

    Ghaleb, Bassam; Hillaire-Marcel, Claude; Ruiz Fernandez, Ana-Carolina; Sanchez Cabeza, Joan-Albert

    2016-04-01

    provide simple models governing these processes under relatively high sedimentation rates, i.e., when Ra-diffusion from the sediment towards the water column may be neglected. In sites characterized by extreme sedimentologival events, 228Th/232Th profiles depict departures from this model, thus bearing information on the timing and processes involved. Examples from the Saguenay Fjord (Canada) illustrate the case of fast-deposited layers due to floods, whereas examples from estuaries and coastal areas of Sinaloa show evidence for re-suspension and/or erosion events linked notably to storminess and/or land use changes. In the first case, the fast accumulation of flood layers has sealed most of the early 20th-century contamination, whereas in the second case, erosion and re-suspension events led to either some removal of sediments contaminated by heavy metals, or their secondary release into the environment.

  8. Dysphagia-gastroesophageal reflux complex: complications due to dysfunction of solitary tract nucleus-mediated vago-vagal reflex.

    Science.gov (United States)

    Saito, Y; Kawashima, Y; Kondo, A; Chikumaru, Y; Matsui, A; Nagata, I; Ohno, K

    2006-06-01

    We report on the complication of gastroesophageal reflux (GER) in four patients with lower brainstem dysfunction. These patients suffered from perinatal asphyxia, cerebellar hemorrhage, or congenital dysphagia of unknown origin and showed facial nerve palsy, inspiratory stridor due to vocal cord paralysis, central sleep apnea, and dysphagia, in various combinations. Naso-intestinal tube feeding was introduced in all of the patients due to recurrent vomiting and aspiration pneumonia resulting from GER. T2-weighted magnetic resonance (MR) imaging revealed symmetrical high intensity lesions in the tegmentum of the lower pons and the medulla oblongata in two of the patients, and pontomedullary atrophy in another patient. In normal subjects, lower esophageal sphincter contraction is provoked by distension of the gastric wall, through a vago-vagal reflex. Since this reflex arc involves the solitary tract nucleus, where the swallowing center is located, the association of dysphagia and GER in the present patients is thought to result from the lesions in the tegmentum of medulla oblongata. We propose the term "dysphagia-GER complex" to describe the disturbed motility of the upper digestive tract due to lower brainstem involvement. In children with brainstem lesions, neurological assessment of GER is warranted, in addition to the examination of other signs of brainstem dysfunction, including dysphagia and respiratory disturbance.

  9. [Successful outcome of a pregnancy with an extremely low fetal heart rate (34 bpm) due to isolated complete heart block--case report].

    Science.gov (United States)

    Hamela-Olkowska, Anita; Dangel, Joanna; Miszczak-Knecht, Maria

    2009-09-01

    Isolated complete congenital heart block (CHB) in the majority of cases is associated with the presence of autoantibodies to SSA (Ro) and SSB (La) antigens in the maternal serum. The prognosis is less favorable in fetuses with a ventricular rate bpm. We have reported a case of a fetus with an isolated non-autoimmune CHB with an extremely low ventricular rate (34bpm) in which the outcome was favorable. In the neonate the non-compaction of the myocardium was diagnosed.

  10. How extreme are extremes?

    Science.gov (United States)

    Cucchi, Marco; Petitta, Marcello; Calmanti, Sandro

    2016-04-01

    High temperatures have an impact on the energy balance of any living organism and on the operational capabilities of critical infrastructures. Heat-wave indicators have been mainly developed with the aim of capturing the potential impacts on specific sectors (agriculture, health, wildfires, transport, power generation and distribution). However, the ability to capture the occurrence of extreme temperature events is an essential property of a multi-hazard extreme climate indicator. Aim of this study is to develop a standardized heat-wave indicator, that can be combined with other indices in order to describe multiple hazards in a single indicator. The proposed approach can be used in order to have a quantified indicator of the strenght of a certain extreme. As a matter of fact, extremes are usually distributed in exponential or exponential-exponential functions and it is difficult to quickly asses how strong was an extreme events considering only its magnitude. The proposed approach simplify the quantitative and qualitative communication of extreme magnitude

  11. Feasibility and outcomes of a classical Pilates program on lower extremity strength, posture, balance, gait, and quality of life in someone with impairments due to a stroke.

    Science.gov (United States)

    Shea, Sarah; Moriello, Gabriele

    2014-07-01

    Pilates is a method that can potentially be used for stroke rehabilitation to address impairments in gait, balance, strength, and posture. The purpose of this case report was to document the feasibility of using Pilates and to describe outcomes of a 9-month program on lower extremity strength, balance, posture, gait, and quality of life in an individual with stroke. The participant was taught Pilates exercises up to two times per week for nine months in addition to traditional rehabilitation in the United States. Outcomes were assessed using the Berg Balance Scale (BBS), Stroke Impact Scale (SIS), GAITRite System(®), 5 repetition sit-to-stand test (STST), and flexicurve. Improvements were found in balance, lower extremity strength, and quality of life. Posture and gait speed remained the same. While these changes cannot be specifically attributed to the intervention, Pilates may have added to his overall rehabilitation program and with some modifications was feasible to use in someone with a stroke. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. Changes in upper-extremity muscle activities due to head position in subjects with a forward head posture and rounded shoulders.

    Science.gov (United States)

    Kwon, Jung Won; Son, Sung Min; Lee, Na Kyung

    2015-06-01

    [Purpose] This study investigated upper-extremity muscle activities in natural, ideal, and corrected head positions. [Subjects and Methods] Forty subjects with a forward head posture and rounded shoulder were recruited and randomly assigned to the natural head position group (n = 13), ideal head position group (n = 14), or corrected head position group (n = 13). Muscle activities were measured using a four-channel surface electromyography system at the sternocleidomastoideus, upper and lower trapezius, and serratus anterior muscles on the right side during an overhead reaching task. [Results] The muscle activities of the upper trapezius and serratus anterior differed significantly among head positions. Post hoc tests revealed significant differences between natural and ideal head positions, and natural and ideal head positions for both the upper trapezius and serratus anterior. [Conclusion] Recovery of normal upper trapezius and serratus anterior muscle functions plays an important role in correcting forward head posture and rounded shoulders.

  13. Gene expression analysis in children with complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis.

    Science.gov (United States)

    Tsuge, Mitsuru; Oka, Takashi; Yamashita, Nobuko; Saito, Yukie; Fujii, Yosuke; Nagaoka, Yoshiharu; Yashiro, Masato; Tsukahara, Hirokazu; Morishima, Tsuneo

    2014-02-01

    Viral infections have been implicated as a cause of complex seizures in children. The pathogenic differences in complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis remain unclear. This study analyzed the gene expression profiles in the peripheral whole blood from pediatric patients with complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis. The gene expression profiles of ten patients (five with seizures and five without) with influenza A(H1N1)pdm09 and six patients (three with seizures and three without) with rotavirus gastroenteritis were examined. Gene expression profiles in the whole blood were different in complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis. Transcripts related to the immune response were significantly differentially expressed in complex seizures with influenza A(H1N1)pdm09, and transcripts related to the stress response were significantly differentially expressed in complex seizures with rotavirus gastroenteritis. Pathway analysis showed that the mitogen-activated protein kinases in the T cell receptor signaling pathway were activated in complex seizures due to influenza A(H1N1)pdm09. Dysregulation of the genes related to immune response or stress response could contribute to the pathogenic differences of the complex seizures due to influenza A(H1N1)pdm09 or rotavirus gastroenteritis.

  14. Total hip prosthesis complication, periprosthetic infection with external fistulizing due to Enterobacter cloacae complex multiple drugs resistance: A clinical case report.

    Science.gov (United States)

    Amorese, V; Corda, M; Donadu, M; Usai, D; Pisanu, F; Milia, F; Marras, F; Sanna, A; Delogu, D; Mazzarello, V; Manzoni, G; Conti, M; Meloni, G B; Zanetti, S; Doria, C

    2017-01-01

    The Enterobacter cloacae is a microorganism found in the intestinal flora of the majority of animals, including humans. Primary infections caused by E. cloacae are rare in immunocompetent patients, but are very common in hospital settings in newborns and immunocompromised patients, and can be aggravated by the insurgence of antibiotic resistance. The incidence of periprosthetic hip infections is just below 2%. A 76year old woman with multiple comorbidities underwent surgical implantation of intermediary total hip prosthesis of the left hip, in a different health facility, in February 2014, after the basicervical fracture of the upper femur extremity due to trauma. After an episode of dislocation of the prosthetic implant, in September 2014, she underwent a surgical operation to implant the acetabular component. A month later not in our facility, following a re-hospitalization for the dislocation of the arthroprosthesis, an infection from E. cloacae complex was discovered. After 2 years of chronic infection she came to our attention; the clinical picture featured coxalgia and secreting fistula in the surgical wound. Following a specific antibiotic therapy, carried out intravenously over the course of a month, we decided to intervene removing the left hip arthroprosthesis and placing an antibiotic spacer following the direction deduced from the antibiogram study of August 2016. The patient was hospitalized in our facility and 2 months later she underwent another operation to remove the antibiotic spacer and to place a new total hip arthroprosthesis. Multiple swabs showed the complete healing from the infection, which was confirmed a couple of months later. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  15. Estimating statistical isotropy violation in CMB due to non-circular beam and complex scan in minutes

    Science.gov (United States)

    Pant, Nidhi; Das, Santanu; Rotti, Aditya; Mitra, Sanjit; Souradeep, Tarun

    2016-03-01

    Mild, unavoidable deviations from circular-symmetry of instrumental beams along with scan strategy can give rise to measurable Statistical Isotropy (SI) violation in Cosmic Microwave Background (CMB) experiments. If not accounted properly, this spurious signal can complicate the extraction of other SI violation signals (if any) in the data. However, estimation of this effect through exact numerical simulation is computationally intensive and time consuming. A generalized analytical formalism not only provides a quick way of estimating this signal, but also gives a detailed understanding connecting the leading beam anisotropy components to a measurable BipoSH characterisation of SI violation. In this paper, we provide an approximate generic analytical method for estimating the SI violation generated due to a non-circular (NC) beam and arbitrary scan strategy, in terms of the Bipolar Spherical Harmonic (BipoSH) spectra. Our analytical method can predict almost all the features introduced by a NC beam in a complex scan and thus reduces the need for extensive numerical simulation worth tens of thousands of CPU hours into minutes long calculations. As an illustrative example, we use WMAP beams and scanning strategy to demonstrate the easability, usability and efficiency of our method. We test all our analytical results against that from exact numerical simulations.

  16. Changes in the Physicochemical Properties of Piperine/β-Cyclodextrin due to the Formation of Inclusion Complexes

    Directory of Open Access Journals (Sweden)

    Toshinari Ezawa

    2016-01-01

    Full Text Available Piperine (PP is a pungent component in black pepper that possesses useful biological activities; however it is practically insoluble in water. The aim of the current study was to prepare a coground mixture (GM of PP and β-cyclodextrin (βCD (molar ratio of PP/βCD = 1/1 and subsequently evaluate the solubility of PP and physicochemical properties of the GM. DSC thermal behavior of the GM showed the absence of melting peak of piperine. PXRD profile of the GM exhibited halo pattern and no characteristic peaks due to PP and βCD were observed. Based on Job’s plot, the PP/βCD complex in solution had a stoichiometric ratio of 1/1. Raman spectrum of the GM revealed scattering peaks assigned for the benzene ring (C=C, the methylene groups (CH2, and ether groups (C-O-C of PP that were broaden and shifted to lower frequencies. SEM micrographs showed that particles in the GM were agglomerated and had rough surface, unlike pure PP and pure βCD particles. At 15 min of dissolution testing, the amount dissolved of PP in the GM was dramatically increased (about 16 times compared to that of pure PP. Moreover the interaction between PP and βCD cavity was detected by 1H-1H NMR nuclear Overhauser effect spectroscopy NMR spectroscopy.

  17. Extremely large non-saturating magnetoresistance and ultrahigh mobility due to topological surface states in metallic Bi2Te3 topological insulator

    OpenAIRE

    Shrestha, K; Chou, M; Graf, D.; Yang, H. D.; Lorenz, B.; Chu, C. W.

    2017-01-01

    Weak antilocalization (WAL) effects in Bi2Te3 single crystals have been investigated at high and low bulk charge carrier concentrations. At low charge carrier density the WAL curves scale with the normal component of the magnetic field, demonstrating the dominance of topological surface states in magnetoconductivity. At high charge carrier density the WAL curves scale with neither the applied field nor its normal component, implying a mixture of bulk and surface conduction. WAL due to topolog...

  18. Genesis of emulsion texture due to magma mixing: a case study from Chotanagpur Granite Gneiss Complex of Eastern India

    Science.gov (United States)

    Gogoi, Bibhuti; Saikia, Ashima; Ahmad, Mansoor

    2016-04-01

    The emulsion texture is a rare magma mixing feature in which rounded bodies of one magmatic phase remain dispersed in the other coherent phase (Freundt and Schmincke, 1992). This type of special texture in hybrid rocks can significantly contribute toward understanding the mechanisms facilitating magma mixing and magma chamber dynamics involving two disparate magmas as the exact processes by which mixing occurs still remain unclear. Recent developments in microfluidics have greatly helped us to understand the complex processes governing magma mixing occurring at micro-level. Presented work uses some of the results obtained from microfluidic experiments with a view to understand the formation mechanism of emulsions preserved in the hybrid rocks of the Ghansura Rhyolite Dome (GRD) of Proterozoic Chotanagpur Granite Gneiss Complex (CGGC), Eastern India. The GRD has preserved hybrid rocks displaying emulsion texture that formed due to the interaction of a phenocryst-rich basaltic magma and host rhyolite magma. The emulsions are more or less spherical in shape and dominantly composed of amphibole having biotite rinds set in a matrix of biotite, plagioclase, K-feldspar and quartz. Amphibole compositions were determined from the core of the emulsions to the rim with a view to check for cationic substitutions. The amphibole constituting the emulsions is actinolite in composition, and commonly shows tschermakite (Ts) and pargasite (Prg) substitutions. From petrographical and mineral-chemical analyses we infer that when mafic magma, containing phenocrysts of augite, came in contact with felsic magma, diffusion of cations like H+, Al3+and others occurred from the felsic to the mafic system. These cations reacted with the clinopyroxene phenocrysts in the mafic magma to form amphibole (actinolite) crystals. The formation of amphibole crystals in the mafic system greatly increased the viscosity of the system allowing the amphibole crystals to venture into the adjacent felsic

  19. Extremely bulky amido first row transition metal(II) halide complexes: potential precursors to low coordinate metal-metal bonded systems.

    Science.gov (United States)

    Hicks, Jamie; Jones, Cameron

    2013-04-01

    Reactions of the extremely bulky potassium amide complexes, [KL'(η(6)-toluene)] or [KL"] (L'/L" = N(Ar*)(SiR3), Ar* = C6H2{C(H)Ph2}2Me-2,6,4; R = Me (L') or Ph (L")), with a series of first row transition metal(II) halides have yielded 10 rare examples of monodentate amido first row transition metal(II) halide complexes, all of which were crystallographically characterized. They encompass the dimeric, square-planar chromium complexes, [{CrL'(THF)(μ-Cl)}2] and [{CrL"(μ-Cl)}2], the latter of which displays intramolecular η(2)-Ph···Cr interactions; the dimeric tetrahedral complexes, [{ML'(THF)(μ-Br)}2] (M = Mn or Fe), [{ML"(THF)(μ-X)}2] (M = Mn, Fe or Co; X = Cl or Br) and [{CoL"(μ-Cl)}2] (which displays intramolecular η(2)-Ph···Co interactions); and the monomeric zinc amides, [L'ZnBr(THF)] (three-coordinate) and [L"ZnBr] (two-coordinate). Solution state magnetic moment determinations on all but one of the paramagnetic compounds show them to be high-spin systems. Throughout, comparisons are made with related bulky terphenyl transition metal(II) halide complexes, and the potential for the use of the prepared complexes as precursors to low-valent transition metal systems is discussed.

  20. [Case of anti VGKC-complex antibody associated disorder presenting with severe pain and fasciculations predominant in unilateral upper extremity].

    Science.gov (United States)

    Hara, Kenju; Watanabe, Osamu; Shibano, Ken; Ishiguro, Hideaki

    2012-01-01

    A 21-year-old man complained of severe pain and muscle twitching localized in his right arm. Neurological examination showed muscle fasciculations in his right forearm but no myokymia or myotonia. Needle electromyography revealed fibrillation potentials in his biceps brachii muscle and extensor carpi radialis muscle at rest but no myokymic discharges. His serum anti-voltage-gated potassium channel (VGKC)-complex antibody level was significantly high (194.2pM; controls VGKC-complex antibody associated disorder.

  1. [Anaesthetic implications in a pregnant patient with an extreme thrombocytopenia due to a May-Hegglin anomaly: general o regional anaesthesia?].

    Science.gov (United States)

    García Vallejo, G; Cabellos, M; Kabiri, M; Fraile, J R; Cuesta, J

    2014-10-01

    The May-Hegglin anomaly is an inherited disorder, so uncommon that the incidence is still unknown. It is characterized by macro-thrombocytopenia with normal platelet function and cytoplasmic inclusion bodies in granulocytes. The case is reported of a 28-year-old primiparous patient who had an urgent caesarean section due to failed induction of labour. The patient had no history of abnormal bleeding. Other causes of thrombocytopenia or platelet dysfunction, such as preeclampsia, HELLP syndrome, or placental abruption, were ruled out. The platelet count prior to surgery was 20,900/mm(3) with normal platelet function. General anaesthesia was performed. No excessive bleeding occurred and a platelet transfusion was not needed. Copyright © 2013 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España. All rights reserved.

  2. Spatial distribution and frequency of precipitation during an extreme event: July 2006 mesoscale convective complexes and floods in southeastern Arizona

    Science.gov (United States)

    Griffiths, P.G.; Magirl, C.S.; Webb, R.H.; Pytlak, E.; Troch, Peter A.; Lyon, S.W.

    2009-01-01

    An extreme, multiday rainfall event over southeastern Arizona during 27-31 July 2006 caused record flooding and a historically unprecedented number of slope failures and debris flows in the Santa Catalina Mountains north of Tucson. An unusual synoptic weather pattern induced repeated nocturnal mesoscale convective systems over southeastern Arizona for five continuous days, generating multiday rainfall totals up to 360 mm. Analysis of point rainfall and weather radar data yielded storm totals for the southern Santa Catalina Mountains at 754 grid cells approximately 1 km ?? 1 km in size. Precipitation intensity for the 31 July storms was not unusual for typical monsoonal precipitation in this region (recurrence interval (RI) 50 years and individual grid cells had RI exceeding 1000 years. The 31 July storms caused the watersheds to be essentially saturated following 4 days of rainfall. Copyright 2009 by the American Geophysical Union.

  3. Extreme low-frequency electric and magnetic fields due to the use of household appliances; Extreem-laagfrequente elektrische en magnetische velden van huishoudelijke apparatuur

    Energy Technology Data Exchange (ETDEWEB)

    Kelfkens, G.; Pruppers, M.J.M.

    2005-07-01

    Exposure to electric and magnetic fields due to the use of most household appliances does not exceed the exposure levels recommended by the European Union. No short-term health effects are to be expected for these appliances. All appliances connected to the power grid are surrounded by electric and magnetic fields to which the user can be exposed. Because some people worry about possible health effects caused by this exposure, it is important to study the electromagnetic fields in the vicinity of household appliances. This report evaluates the scientific investigations of health effects that may occur in using household appliances. The legislation for the use of these appliances in both the European Union and the Netherlands is also described. Finally, an overview is given of comparative measurements with respect to the magnetic fields and exposure in the neighbourhood of household appliances. Scientific literature, which is not always up to date, suggests that for some household appliances possibly still in use, the magnetic fields will exceed the exposure levels advised by the EU. As a result of both technological improvement and the current obligation that household appliances comply with a European standard, exceeding the levels advised by the EU for appliances that come onto the market is less likely. The exposure levels recommended by the EU are based on effects that occur during or shortly afterwards exposure. It cannot be ruled out that exposure below these levels may lead to long-term health effects. However, there is no scientific evidence for a relationship between cancer and the use of household appliances. [Dutch] De blootstelling aan elektrische en magnetische velden ligt voor de meeste huishoudelijke apparaten onder de niveaus die de Europese Unie aanbeveelt. Voor die apparaten zijn geen gezondheidseffecten op de korte termijn te verwachten. Elk apparaat dat op het elektriciteitsnet is aangesloten, heeft een elektrisch en magnetisch veld om zich heen

  4. Complex carbohydrates of red wine: characterization of the extreme diversity of neutral oligosaccharides by ESI-MS.

    Science.gov (United States)

    Doco, Thierry; Williams, Pascale; Meudec, Emmanuelle; Cheynier, Véronique; Sommerer, Nicolas

    2015-01-21

    The major neutral oligosaccharides of a Carignan red wine have been characterized for the first time. The oligosaccharides were prepared after removal of phenolic compounds by polyamide chromatography and of polysaccharides by alcohol precipitation and then were fractionated by anion exchange and size-exclusion chromatography. In a second step, the glycosyl composition and linkages of wine oligosaccharides were determined. Oligosaccharide fractions were analyzed by mass spectrometry (MS) with an electrospray ionization (ESI) source and an ion trap mass analyzer after separation by hydrophilic interaction liquid chromatography on a Nucleodur HILIC column (zwitterionic sulfoalkyl betaine stationary phase). Glycosyl residue composition analysis showed the predominant presence of arabinose, with galactose, rhamnose, and mannose in lower proportion. Neutral oligosaccharides were present at a concentration of 185 mg/L in this wine. The MS spectra in the negative ion mode of the oligosaccharide fractions showed a series of oligosaccharidic structures corresponding to oligo-arabinans often linked to the basic unit α-l-Rhap-(1 → 4)-α-d-GalpA. The wine oligosaccharides identified correspond to arabino-oligosaccharides, rhamno-arabino-oligosaccharides, and different rhamnogalacturonan-arabino-oligosaccharides with DP ranging from 5 to 49, resulting from the degradation of grape cell wall pectins. Oligosaccharides have an extreme diversity, with more than 100 peaks detected in HPLC-ESI-MS spectra corresponding each to at least one oligosaccharidic structure.

  5. Mitochondrial hepato-encephalopathy due to deficiency of QIL1/MIC13 (C19orf70), a MICOS complex subunit.

    Science.gov (United States)

    Zeharia, Avraham; Friedman, Jonathan R; Tobar, Ana; Saada, Ann; Konen, Osnat; Fellig, Yacov; Shaag, Avraham; Nunnari, Jodi; Elpeleg, Orly

    2016-12-01

    The mitochondrial inner membrane possesses distinct subdomains including cristae, which are lamellar structures invaginated into the mitochondrial matrix and contain the respiratory complexes. Generation of inner membrane domains requires the complex interplay between the respiratory complexes, mitochondrial lipids and the recently identified mitochondrial contact site and cristae organizing system (MICOS) complex. Proper organization of the mitochondrial inner membrane has recently been shown to be important for respiratory function in yeast. Here we aimed at a molecular diagnosis in a brother and sister from a consanguineous family who presented with a neurodegenerative disorder accompanied by hyperlactatemia, 3-methylglutaconic aciduria, disturbed hepatocellular function with abnormal cristae morphology in liver and cerebellar and vermis atrophy, which suggest mitochondrial dysfunction. Using homozygosity mapping and exome sequencing the patients were found to be homozygous for the p.(Gly15Glufs*75) variant in the QIL1/MIC13 (C19orf70) gene. QIL1/MIC13 is a constituent of MICOS, a six subunit complex that helps to form and/or stabilize cristae junctions and determine the placement, distribution and number of cristae within mitochondria. In patient fibroblasts both MICOS subunits QIL1/MIC13 and MIC10 were absent whereas MIC60 was present in a comparable abundance to that of the control. We conclude that QIL1/MIC13 deficiency in human, is associated with disassembly of the MICOS complex, with the associated aberration of cristae morphology and mitochondrial respiratory dysfunction. 3-Methylglutaconic aciduria is associated with variants in genes encoding mitochondrial inner membrane organizing determinants, including TAZ, DNAJC19, SERAC1 and QIL1/MIC13.

  6. Increasing fat in the diet does not improve muscle performance in patients with mitochondrial myopathy due to complex I deficiency

    NARCIS (Netherlands)

    de Meer, K; Roef, MJ; de Klerk, JBC; Bakker, HD; Smit, GPA; Poll-The, BT

    2005-01-01

    Four myopathic patients with complex I deficiency followed diets containing 55 energy per cent (En%) as fat or 25 En% as fat, both for three weeks. Maximal workload and muscle force were not different on either diet. Exercise endurance time, oxygen consumption and lactate levels were also not differ

  7. Triacylglycerol infusion does not improve hyperlactemia in resting patients with mitochondrial myopathy due to complex I deficiency

    NARCIS (Netherlands)

    Roef, MJ; de Meer, K; Reijngoud, DJ; Straver, HWHC; de Barse, M; Kalhan, SC; Berger, R

    2002-01-01

    Background: A high-fat diet has been recommended for correction of biochemical abnormalities and muscle energy state in patients with complex I (NADH dehydrogenase) deficiency (CID). Objective: This study evaluated the effects of intravenous infusion of isoenergetic amounts of triacylglycerol or glu

  8. Reduction of protein adsorption on silica and polystyrene surfaces due to coating with Complex Coacervate Core Micelles

    NARCIS (Netherlands)

    Brzozowska, A. M.; Hofs, B.; de Keizer, A.; Fokkink, R.; Stuart, Martien A. Cohen; Norde, W.

    2009-01-01

    The reduction of protein adsorption by a polymer brush formed upon adsorption of Complex Coacervate Core Micelles (C3Ms), consisting of a charged copolymer containing a neutral block and an oppositely charged homopolymer, on silica and polystyrene surfaces has been studied in situ using fixed angle

  9. Respiratory chain complex I deficiency due to NDUFA12 mutations as a new cause of Leigh syndrome

    DEFF Research Database (Denmark)

    Ostergaard, Elsebet; Rodenburg, Richard J; van den Brand, Mariël;

    2011-01-01

    This study investigated a girl with Leigh syndrome born to first-cousin parents of Pakistani descent with an isolated respiratory chain complex I deficiency in muscle and fibroblasts. Her early development was delayed, and from age 2 years she started losing motor abilities. Cerebral MRI showed...

  10. Dolphin social intelligence: complex alliance relationships in bottlenose dolphins and a consideration of selective environments for extreme brain size evolution in mammals.

    Science.gov (United States)

    Connor, Richard C

    2007-04-29

    Bottlenose dolphins in Shark Bay, Australia, live in a large, unbounded society with a fission-fusion grouping pattern. Potential cognitive demands include the need to develop social strategies involving the recognition of a large number of individuals and their relationships with others. Patterns of alliance affiliation among males may be more complex than are currently known for any non-human, with individuals participating in 2-3 levels of shifting alliances. Males mediate alliance relationships with gentle contact behaviours such as petting, but synchrony also plays an important role in affiliative interactions. In general, selection for social intelligence in the context of shifting alliances will depend on the extent to which there are strategic options and risk. Extreme brain size evolution may have occurred more than once in the toothed whales, reaching peaks in the dolphin family and the sperm whale. All three 'peaks' of large brain size evolution in mammals (odontocetes, humans and elephants) shared a common selective environment: extreme mutual dependence based on external threats from predators or conspecific groups. In this context, social competition, and consequently selection for greater cognitive abilities and large brain size, was intense.

  11. X-linked myotubular myopathy due to a complex rearrangement involving a duplication of MTM1 exon 10

    NARCIS (Netherlands)

    Trump, N.; Cullup, T.; Verheij, J. B. G. M.; Manzur, A.; Muntoni, F.; Abbs, S.; Jungbluth, H.

    2012-01-01

    X-linked myotubular myopathy is a predominantly severe congenital myopathy with central nuclei on muscle biopsy due to mutations in the MTM1 gene encoding myotubularin. We report a boy with typical features of X-linked myotubular myopathy. Sequencing of the MTM1 gene did not reveal any causative mut

  12. Upper Extremity Muscle Activation during Bodyblade Exercises Following Six Weeks of Intervention Focusing on the Lumbopelvic-Hip Complex

    Directory of Open Access Journals (Sweden)

    Gretchen D. Oliver

    2015-08-01

    Full Text Available The current study examined the effects of a six-week lumbopelvic-hip complex (LPHC strengthening program on muscle activation when performing the shoulder dump exercise. The shoulder dump is a total body exercise that includes overhead arm movements. A pre-post test with a control group was implemented. Twenty-seven graduate students (23.5 ± 1.34 yr; 174.4 ± 11.0 cm; 76.6 ± 16.9 kg participated. Participants were randomly assigned to a control or intervention group where the intervention group performed LPHC exercises. Two-way analysis of variance (ANOVA revealed a significant increase in muscle activation of the serratus anterior from pre- and post-LPHC intervention, (t = 6.5, p < 0.001. As presented by these data, incorporation of LPHC exercises may assist in facilitating greater activation in some of the scapula-stabilizing musculature that has traditionally been rehabilitated in prone or side-lying positions. It is, therefore, suggested that LPHC exercises be incorporated in a regular shoulder rehabilitation program.

  13. Extreme Heat

    Science.gov (United States)

    ... Landslides & Debris Flow Nuclear Blast Nuclear Power Plants Power Outages Pandemic Radiological Dispersion Device Severe Weather Snowstorms & Extreme ... Landslides & Debris Flow Nuclear Blast Nuclear Power Plants Power Outages Pandemic Radiological Dispersion Device Severe Weather Snowstorms & Extreme ...

  14. Mandelbrot's Extremism

    NARCIS (Netherlands)

    Beirlant, J.; Schoutens, W.; Segers, J.J.J.

    2004-01-01

    In the sixties Mandelbrot already showed that extreme price swings are more likely than some of us think or incorporate in our models.A modern toolbox for analyzing such rare events can be found in the field of extreme value theory.At the core of extreme value theory lies the modelling of maxima

  15. Complex hydrologic changes in frequency-magnitude response due to shifting agricultural practices in the Midwestern U.S.

    Science.gov (United States)

    Takbiri, Z.; Czuba, J. A.; Foufoula-Georgiou, E.

    2014-12-01

    Hydrologic change is occurring in many basins throughout the Midwestern U.S. not only in the mean annual streamflow but across a spectrum of magnitudes and frequencies. Disentangling the causative mechanisms responsible for these changes such as anthropogenic factors, e.g., artificial drainage to increase agricultural productivity, and climatic shifts in precipitation patterns is important for planning effective mitigation strategies. We have begun unraveling these changes in a human impacted agricultural landscape in the Midwestern U.S., specifically two subbasins of the Minnesota River Basin in Minnesota: the Redwood and Whetstone River Basins, where there has been a shift in agriculture from small grains to soybeans. This shift occurred at different times for each basin (1976 and 1991, respectively) and when soy covered about 20% of the basin area an apparent shift in the hydrologic regime also occurred as evidence by visual inspection of the hydrographs. Precisely quantifying the nature of this hydrologic regime shift however is a challenge and this work adds in this direction. Using Copulas and the joint probability distribution of daily precipitation and streamflow, we quantified a significantly higher dependence between precipitation and streamflow increments in the mid-quantiles (0.1-0.6; attributed to the artificial drainage to the stream rather than the slower infiltration and subsurface runoff) and no significant change for high quantiles (because for extreme storms the artificially fast drainage does not differ much hydrologically from the naturally fast overland flow). We further performed a multi-scale analysis of streamflow increments via wavelets to quantify the changes in the magnitude and frequency of the rising and falling limbs of hydrographs, confirming the above findings. Since precipitation changes were confirmed not to be significant, it is suggested that streamflow changes are largely driven by a change in land use and not climate in these

  16. Geochemical characteristics of hydrous basaltic magmas due to assimilation and fractional crystallization: the Ikoma gabbroic complex, southwest Japan

    Science.gov (United States)

    Koizumi, N.; Okudaira, T.; Ogawa, D.; Yamashita, K.; Suda, Y.

    2016-10-01

    To clarify the processes that occur in hydrous basaltic magma chambers, we have undertaken detailed petrological and geochemical analyses of mafic and intermediate rocks from the Ikoma gabbroic complex, southwest Japan. The complex consists mainly of hornblende gabbros, hornblende gabbronorites, and hornblende leucogabbros. The hornblende leucogabbros are characterized by low TiO2 and high CaO contents, whereas the hornblende gabbronorites have high TiO2 and low CaO contents. The initial 87Sr/86Sr ratios (SrI) of the hornblende gabbronorites and hornblende gabbros are higher than those of the hornblende leucogabbros and plagioclase, and they may have resulted from a higher degree of assimilation of metasediments. The geochemical features of the hornblende leucogabbros and hornblende gabbronorites can be explained by accumulation of plagioclase and ilmenite, respectively, in a hybrid magma that formed by chemical interaction between mafic magma and metasediment, whereas the hornblende gabbros were produced by a high degree of crustal assimilation and fractional crystallization of this hybrid magma. As a result of the density differences between crystals and melt, the Ikoma gabbroic rocks formed by the accumulation of plagioclase in the middle of the magma chamber and by the accumulation of ilmenite in the bottom of the chamber. Taking into account the subsequent assimilation and fractional crystallization, our observations suggest an enriched mantle (SrI = ~0.7071) as the source material for the Ikoma gabbros.

  17. Complex oligomeric structure of a truncated form of DdrA: A protein required for the extreme radio-tolerance of Deinococcus

    Energy Technology Data Exchange (ETDEWEB)

    Gutsche, I. [CNRS-EMBL-Univ Grenoble 1, Unit Virus Host Cell Interact UMR5233, F-38042 Grenoble (France); Vujicic-Zagar, A.; Serre, L. [CEA-CNRS-Univ Grenoble 1, Inst Biol Struct, UMR5075, Lab Prot Membranaires, F-38027 Grenoble 01 (France); Siebert, X. [CEA-CNRS-Univ Grenoble 1, Inst Biol Struct UMR5075, Lab Microscopie Elect et struct, F-38027 Grenoble 01 (France); Servant, P.; Vannier, F.; Sommer, S. [Univ Paris 11, CNRS UMR 8621, CEA LRC42V, Inst Genet et Microbiol, F-91405 Orsay (France); Castaing, B. [CNRS, UMR4301, Ctr Biophys Mol, F-45071 Orleans 02 (France); Gallet, B. [CEA-CNRS-Univ Grenoble 1, Inst Biol Struct UMR 5075, ROBIOMOL, Lab Ingn Macrom, F-38027 Grenoble 01 (France); Heulin, T.; De Groot, A. [CEA, DSV, IBEB, SBVME, Lab Ecol Microbienne Rhizosphere et Environm Extre, UMR 6191, F-13108 St Paul Les Durance (France)

    2008-07-01

    In order to preserve their genome integrity, organisms have developed elaborate tactics for genome protection and repair. The Deinococcus radiodurans bacteria famous for their extraordinary tolerance toward high doses of radiations or long period of desiccation, possess some specific genes with unknown function which are related to their survival in such extreme conditions. Among them, ddrA is an orphan gene specific of Deinococcus genomes. DdrA, the product of this gene was suggested to be a component of the DNA end protection system. Here we provide a three-dimensional reconstruction of the Deinococcus deserti DdrA(1-160) by electron microscopy. Although not functional in vivo, this truncated protein keeps its DNA binding ability at the wild-type level. DdrA(1-160) has a complex three-dimensional structure based on a hepta-meric ring that can self-associate to form a larger molecular weight assembly. We suggest that the complex architecture of DdrA plays a role in the substrate specificity and favors an efficient DNA repair. (authors)

  18. Variation of bulk Lorentz factor in AGN jets due to Compton rocket in a complex photon field

    CERN Document Server

    Vuillaume, Thomas; Petrucci, Pierre-Olivier

    2015-01-01

    Radio-loud active galactic nuclei are among the most powerful objects in the universe. In these objects, most of the emission comes from relativistic jets getting their power from the accretion of matter onto supermassive black holes. However, despite the number of studies, a jet's acceleration to relativistic speeds is still poorly understood. It is widely known that jets contain relativistic particles that emit radiation through several physical processes, one of them being the inverse Compton scattering of photons coming from external sources. In the case of a plasma composed of electrons and positrons continuously heated by the turbulence, inverse Compton scattering can lead to relativistic bulk motions through the Compton rocket effect. We investigate this process and compute the resulting bulk Lorentz factor in the complex photon field of an AGN composed of several external photon sources. We consider various sources here: the accretion disk, the dusty torus, and the broad line region. We take their geo...

  19. Pseudotumors due to IgG4 immune-complex tubulointerstitial nephritis associated with autoimmune pancreatocentric disease.

    Science.gov (United States)

    Cornell, Lynn D; Chicano, Sonia L; Deshpande, Vikram; Collins, A Bernard; Selig, Martin K; Lauwers, Gregory Y; Barisoni, Laura; Colvin, Robert B

    2007-10-01

    Autoimmune pancreatitis (AIP) is a mass-forming chronic fibroinflammatory condition centered on the pancreatobiliary system and characterized by predominant immunoglobulin G4 (IgG4)-positive plasma cells. Recent reports have brought to light the multiorgan involvement of this disease. We describe a series of 5 cases of tubulointerstitial nephritis (TIN) associated with AIP and characterize the clinical, pathologic, ultrastructural, and immunopathologic features of TIN. The specimens consisted of 4 biopsies and 1 nephrectomy. The average patient age was 64 years (range 45 to 78) and the male to female ratio was 4:1. All had histologic and/or clinical and radiographic evidence of AIP, mass-forming sclerosing cholangitis, or both. The clinical impression in 4 patients was a renal mass or vasculitis. Two patients had renal insufficiency. Histologic preparations revealed a dense tubulointerstitial lymphoplasmacytic infiltrate. Eosinophils were often numerous. Tubulitis and tubular injury were present, along with tubular atrophy with focally thickened tubular basement membranes (TBMs). The histologic appearance ranged from a cellular, inflammatory pattern without tubular atrophy to a striking expansive interstitial fibrosis with tubular destruction. The nephrectomy specimen demonstrated a masslike nodular pattern of inflammation with normal renal tissue elsewhere. Glomeruli were uninvolved. By immunohistochemistry or immunofluorescence, numerous plasma cells in the infiltrate were positive for IgG4. TBM granular IgG deposits, predominantly of the IgG4 subclass, were detected in 4 of 5 cases by either immunofluorescence or immunohistochemistry. By electron microscopy, corresponding amorphous electron-dense deposits were present in the TBM in these cases. This type of TIN, typically characterized by a masslike lesion consisting of a lymphoplasmacytic infiltrate with eosinophils and prominent IgG4-positive plasma cells and immune-complex deposits in the TBM, may be part of

  20. Critical coupling and coherent perfect absorption for ranges of energies due to a complex gain and loss symmetric system

    Energy Technology Data Exchange (ETDEWEB)

    Hasan, Mohammad, E-mail: mohammadhasan786@gmail.com [ISRO Satellite Centre (ISAC), Bangalore-560017 (India); Ghatak, Ananya, E-mail: gananya04@gmail.com [Department of Physics, Banaras Hindu University, Varanasi-221005 (India); Mandal, Bhabani Prasad, E-mail: bhabani.mandal@gmail.com [Department of Physics, Banaras Hindu University, Varanasi-221005 (India)

    2014-05-15

    We consider a non-Hermitian medium with a gain and loss symmetric, exponentially damped potential distribution to demonstrate different scattering features analytically. The condition for critical coupling (CC) for unidirectional wave and coherent perfect absorption (CPA) for bidirectional waves are obtained analytically for this system. The energy points at which total absorption occurs are shown to be the spectral singular points for the time reversed system. The possible energies at which CC occurs for left and right incidence are different. We further obtain periodic intervals with increasing periodicity of energy for CC and CPA to occur in this system. -- Highlights: •Energy ranges for CC and CPA are obtained explicitly for complex WS potential. •Analytical conditions for CC and CPA for PT symmetric WS potential are obtained. •Conditions for left and right CC are shown to be different. •Conditions for CC and CPA are shown to be that of SS for the time reversed system. •Our model shows the great flexibility of frequencies for CC and CPA.

  1. Outbreak of Burkholderia cepacia complex bacteremia in a chemotherapy day care unit due to intrinsic contamination of an antiemetic drug

    Directory of Open Access Journals (Sweden)

    T Singhal

    2015-01-01

    Full Text Available Background: In the end of 2009, a large number of patients with cancer undergoing chemotherapy at the day care unit of a private hospital in Mumbai, India developed Burkholderia cepacia complex (BCC blood stream infection (BSI. Objective: The objectives were to identify the source of the outbreak and terminate the outbreak as rapidly as possible. Materials and Methods: All infection control protocols and processes were reviewed. Intensive training was started for all nursing staff involved in patient care. Cultures were sent from the environment (surfaces, water, air, intravenous fluids, disinfectants and antiseptics and opened/unopened medication. Results: A total of 13 patients with cancer with tunneled catheters were affected with BCC BSI. The isolates were of similar antimicrobial sensitivity. No significant breach of infection control protocols could be identified. Cultures from the prepared intravenous medication bags grew BCC. Subsequently, culture from unused vials of the antiemetic granisetron grew BCC, whereas those from the unopened IV fluid bag and chemotherapy medication were negative. On review, it was discovered that the outbreak started when a new brand of granisetron was introduced. The result was communicated to the manufacturer and the brand was withdrawn. There were no further cases. Conclusions: This outbreak was thus linked to intrinsic contamination of medication vials. We acknowledge a delay in identifying the source as we were concentrating more on human errors in medication preparation and less on intrinsic contamination. We recommend that in an event of an outbreak, unopened vials be cultured at the outset.

  2. Neonatal multiorgan failure due to ACAD9 mutation and complex I deficiency with mitochondrial hyperplasia in liver, cardiac myocytes, skeletal muscle, and renal tubules.

    Science.gov (United States)

    Leslie, Nancy; Wang, Xinjian; Peng, Yanyan; Valencia, C Alexander; Khuchua, Zaza; Hata, Jessica; Witte, David; Huang, Taosheng; Bove, Kevin E

    2016-03-01

    Complex I deficiency causes Leigh syndrome, fatal infant lactic acidosis, and neonatal cardiomyopathy. Mutations in more than 100 nuclear DNA and mitochondrial DNA genes miscode for complex I subunits or assembly factors. ACAD9 is an acyl-CoA dehydrogenase with a novel function in assembly of complex I; biallelic mutations cause progressive encephalomyopathy, recurrent Reye syndrome, and fatal cardiomyopathy. We describe the first autopsy in fatal neonatal lethal lactic acidosis due to mutations in ACAD9 that reduced complex I activity. We identified mitochondrial hyperplasia in cardiac myocytes, diaphragm muscle, and liver and renal tubules in formalin-fixed, paraffin-embedded tissue using immunohistochemistry for mitochondrial antigens. Whole-exome sequencing revealed compound heterozygous variants in the ACAD9 gene: c.187G>T (p.E63*) and c.941T>C (p.L314P). The nonsense mutation causes late infantile lethality; the missense variant is novel. Autopsy-derived fibroblasts had reduced complex I activity (53% of control) with normal activity in complexes II to IV, similar to reported cases of ACAD9 deficiency.

  3. Earth modeling and estimation of the local seismic ground motion due to site geology in complex volcanoclastic areas

    Directory of Open Access Journals (Sweden)

    V. Di Fiore

    2002-06-01

    Full Text Available Volcanic areas often show complex behaviour as far as seismic waves propagation and seismic motion at surface are concerned. In fact, the finite lateral extent of surface layers such as lava flows, blocks, differential welding and/or zeolitization within pyroclastic deposits, introduces in the propagation of seismic waves effects such as the generation of surface waves at the edge, resonance in lateral direction, diffractions and scattering of energy, which tend to modify the amplitude as well as the duration of the ground motion. The irregular topographic surface, typical of volcanic areas, also strongly influences the seismic site response. Despite this heterogeneity, it is unfortunately a common geophysical and engineering practice to evaluate even in volcanic environments the subsurface velocity field with monodimensional investigation method (i.e. geognostic soundings, refraction survey, down-hole, etc. prior to the seismic site response computation which in a such cases is obviously also made with 1D algorithms. This approach often leads to highly inaccurate results. In this paper we use a different approach, i.e. a fully 2D P-wave Çturning rayÈ tomographic survey followed by 2D seismic site response modeling. We report here the results of this approach in three sites located at short distance from Mt. Vesuvius and Campi Flegrei and characterized by overburdens constituted by volcanoclastic deposits with large lateral and vertical variations of their elastic properties. Comparison between 1D and 2D Dynamic Amplification Factor shows in all reported cases entirely different results, both in terms of peak period and spectral contents, as expected from the clear bidimensionality of the geological section. Therefore, these studies suggest evaluating carefully the subsoil geological structures in areas characterized by possible large lateral and vertical variations of the elastic properties in order to reach correct seismic site response

  4. Maize meiotic mutants with improper or non-homologous synapsis due to problems in pairing or synaptonemal complex formation

    Science.gov (United States)

    Golubovskaya, Inna N.; Wang, C. J. Rachel; Timofejeva, Ljudmilla; Cande, W. Zacheus

    2011-01-01

    During meiotic prophase homologous chromosomes find each other and pair. Then they synapse, as the linear protein core (axial element or lateral element) of each homologous chromosome is joined together by a transverse central element, forming the tripartite synaptonemal complex (SC). Ten uncloned Zea mays mutants in our collection were surveyed by transmission electron microscopy by making silver-stained spreads of SCs to identify mutants with non-homologous synapsis or improper synapsis. To analyse the mutants further, zyp1, the maize orthologue of the Arabidopsis central element component ZYP1 was cloned and an antibody was made against it. Using antibodies against ZYP1 and the lateral element components AFD1 and ASY1, it was found that most mutants form normal SCs but are defective in pairing. The large number of non-homologous synapsis mutants defective in pairing illustrates that synapsis and pairing can be uncoupled. Of the ten mutants studied, only dsy2 undergoes normal homologous chromosome recognition needed for homologous pairing. The dsy2 mutation fails to maintain the SC. ZYP1 elongation is blocked at zygotene, and only dots of ZYP1 are seen at prophase I. Another mutant, mei*N2415 showed incomplete but homologous synapsis and ASY1 and AFD1 have a normal distribution. Although installation of ZYP1 is initiated at zygotene, its progression is slowed down and not completed by pachytene in some cells and ZYP1 is not retained on pachytene chromosomes. The mutants described here are now available through the Maize Genetics Cooperation Stock Center (http://maizecoop.cropsci.uiuc.edu/). PMID:20926553

  5. Phenotypic Spectrum in Osteogenesis Imperfecta Due to Mutations in TMEM38B: Unraveling a Complex Cellular Defect.

    Science.gov (United States)

    Webb, Emma A; Balasubramanian, Meena; Fratzl-Zelman, Nadja; Cabral, Wayne A; Titheradge, Hannah; Alsaedi, Atif; Saraff, Vrinda; Vogt, Julie; Cole, Trevor; Stewart, Susan; Crabtree, Nicola J; Sargent, Brandi M; Gamsjaeger, Sonja; Paschalis, Eleftherios P; Roschger, Paul; Klaushofer, Klaus; Shaw, Nick J; Marini, Joan C; Högler, Wolfgang

    2017-06-01

    Recessive mutations in TMEM38B cause type XIV osteogenesis imperfecta (OI) by dysregulating intracellular calcium flux. Clinical and bone material phenotype description and osteoblast differentiation studies. Natural history study in pediatric research centers. Eight patients with type XIV OI. Clinical examinations included bone mineral density, radiographs, echocardiography, and muscle biopsy. Bone biopsy samples (n = 3) were analyzed using histomorphometry, quantitative backscattered electron microscopy, and Raman microspectroscopy. Cellular differentiation studies were performed on proband and control osteoblasts and normal murine osteoclasts. Type XIV OI clinical phenotype ranges from asymptomatic to severe. Previously unreported features include vertebral fractures, periosteal cloaking, coxa vara, and extraskeletal features (muscular hypotonia, cardiac abnormalities). Proband lumbar spine bone density z score was reduced [median -3.3 (range -4.77 to +0.1; n = 7)] and increased by +1.7 (1.17 to 3.0; n = 3) following bisphosphonate therapy. TMEM38B mutant bone has reduced trabecular bone volume, osteoblast, and particularly osteoclast numbers, with >80% reduction in bone resorption. Bone matrix mineralization is normal and nanoporosity low. We demonstrate a complex osteoblast differentiation defect with decreased expression of early markers and increased expression of late and mineralization-related markers. Predominance of trimeric intracellular cation channel type B over type A expression in murine osteoclasts supports an intrinsic osteoclast defect underlying low bone turnover. OI type XIV has a bone histology, matrix mineralization, and osteoblast differentiation pattern that is distinct from OI with collagen defects. Probands are responsive to bisphosphonates and some show muscular and cardiovascular features possibly related to intracellular calcium flux abnormalities.

  6. Extreme-scale Algorithms and Solver Resilience

    Energy Technology Data Exchange (ETDEWEB)

    Dongarra, Jack [Univ. of Tennessee, Knoxville, TN (United States)

    2016-12-10

    A widening gap exists between the peak performance of high-performance computers and the performance achieved by complex applications running on these platforms. Over the next decade, extreme-scale systems will present major new challenges to algorithm development that could amplify this mismatch in such a way that it prevents the productive use of future DOE Leadership computers due to the following; Extreme levels of parallelism due to multicore processors; An increase in system fault rates requiring algorithms to be resilient beyond just checkpoint/restart; Complex memory hierarchies and costly data movement in both energy and performance; Heterogeneous system architectures (mixing CPUs, GPUs, etc.); and Conflicting goals of performance, resilience, and power requirements.

  7. Mitochondrial respiratory chain enzyme assay and DNA analysis in peripheral blood leukocytes for the etiological study of Chinese children with Leigh syndrome due to complex I deficiency.

    Science.gov (United States)

    Ma, Yan Yan; Wu, Tong Fei; Liu, Yu Peng; Wang, Qiao; Li, Xi Yuan; Zhang, Yao; Song, Jin Qing; Wang, Yu Jie; Yang, Yan Ling

    2013-02-01

    Mitochondrial respiratory chain complex I enzyme deficiency is the most commonly seen mitochondrial respiratory chain disorder. Although screening and diagnostic methods are available overseas, clinically feasible diagnostic methods have not yet been established in China. In this study, four Chinese boys with Leigh syndrome due to complex I deficiency were diagnosed by mitochondrial respiratory chain enzyme assay and DNA analysis using peripheral blood leukocytes. Four patients were admitted at the age of 5-14 years because of unexplained progressive neuromuscular symptoms, including motor developmental delay or regression, weakness, and seizures. Their cranial magnetic resonance imaging revealed typical finding as Leigh syndrome. Peripheral leukocyte mitochondrial respiratory chain complex I activities were found decreased to 9.6-33.1 nmol/min/mg mitochondrial protein(control 44.0 ± 5.4 nmol/min/mg). The ratios of complex I to citrate synthase activity were also decreased (8.9-19.8% in patients vs. control 48 ± 11%). Three mtDNA mutations were identified from three out of four patients, supporting the diagnosis of complex I deficiency. Point mutations m.10191T>C in mitochondrial ND3 gene, m.13513G>A in ND5 gene and m.14,453G>A in ND6 gene were detected in three patients.

  8. Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain.

    Science.gov (United States)

    2016-08-29

    Trigeminal Neuralgia (Burchiel Type I); Trigeminal Neuralgia (Burchiel Type II); Trigeminal Neuropathic Pain; Trigeminal Deafferentation Pain; Complex Regional Pain Syndrome (Types I and II, Involving the Upper Extremity); Glossopharyngeal Neuralgia; Upper Extremity Pain Due to Deafferentation of the Cervical Spine; Central Pain Syndromes

  9. Non coding extremities of the seven influenza virus type C vRNA segments: effect on transcription and replication by the type C and type A polymerase complexes

    Directory of Open Access Journals (Sweden)

    van der Werf Sylvie

    2008-10-01

    Full Text Available Abstract Background The transcription/replication of the influenza viruses implicate the terminal nucleotide sequences of viral RNA, which comprise sequences at the extremities conserved among the genomic segments as well as variable 3' and 5' non-coding (NC regions. The plasmid-based system for the in vivo reconstitution of functional ribonucleoproteins, upon expression of viral-like RNAs together with the nucleoprotein and polymerase proteins has been widely used to analyze transcription/replication of influenza viruses. It was thus shown that the type A polymerase could transcribe and replicate type A, B, or C vRNA templates whereas neither type B nor type C polymerases were able to transcribe and replicate type A templates efficiently. Here we studied the importance of the NC regions from the seven segments of type C influenza virus for efficient transcription/replication by the type A and C polymerases. Results The NC sequences of the seven genomic segments of the type C influenza virus C/Johannesburg/1/66 strain were found to be more variable in length than those of the type A and B viruses. The levels of transcription/replication of viral-like vRNAs harboring the NC sequences of the respective type C virus segments flanking the CAT reporter gene were comparable in the presence of either type C or type A polymerase complexes except for the NS and PB2-like vRNAs. For the NS-like vRNA, the transcription/replication level was higher after introduction of a U residue at position 6 in the 5' NC region as for all other segments. For the PB2-like vRNA the CAT expression level was particularly reduced with the type C polymerase. Analysis of mutants of the 5' NC sequence in the PB2-like vRNA, the shortest 5' NC sequence among the seven segments, showed that additional sequences within the PB2 ORF were essential for the efficiency of transcription but not replication by the type C polymerase complex. Conclusion In the context of a PB2-like reporter

  10. Extreme cosmos

    CERN Document Server

    Gaensler, Bryan

    2011-01-01

    The universe is all about extremes. Space has a temperature 270°C below freezing. Stars die in catastrophic supernova explosions a billion times brighter than the Sun. A black hole can generate 10 million trillion volts of electricity. And hypergiants are stars 2 billion kilometres across, larger than the orbit of Jupiter. Extreme Cosmos provides a stunning new view of the way the Universe works, seen through the lens of extremes: the fastest, hottest, heaviest, brightest, oldest, densest and even the loudest. This is an astronomy book that not only offers amazing facts and figures but also re

  11. In situ investigation on rapid microstructure evolution in extreme complex environment by developing a new AFBP-TVM sparse tomography algorithm from original CS-XPCMT

    Science.gov (United States)

    Xu, Feng; Dong, Bo; Hu, Xiaofang; Xiao, Yu; Wang, Yang

    2017-09-01

    A new sparse tomography method for observing the rapid internal microstructure evolution of material, called the Algebraic Filtered-Back-Projection and Total Variation Minimization (AFBP-TVM) iteration sparse reconstruction algorithm, was proposed in this paper. The new algorithm was developed by combining the two techniques of the Algebraic Reconstruction Technique (ART) and the Filtered-Back-Projection (FBP) on the basis of analysis in linear space. A series of numerical reconstruction experiments were conducted to validate the new algorithm. The results indicated the new algorithm can obtain satisfactory reconstruction images from 1/6 of the projections that were used in traditional algorithms. So the time spent on projection acquisition process can be reduced to 1/6 of that in traditional tomography method. The quality of images reconstructed by new algorithm was better than other algorithms, which was evaluated by three quantitative parameters. The normalized average absolute distance criterion and the normalized mean square criterion, which were used to evaluate the relative error of the reconstruction results (smaller value means better quality of reconstruction), decreased from 0.3758 to 0.1272 and from 0.1832 to 0.0894 respectively. The standardized covariance criterion, which was used to evaluate the similarity level (greater value means higher accuracy of reconstruction), increased from 92.72% to 99.30%. Finally, the new algorithm was validated under actual experimental conditions. The results indicated that the AFBP-TVM algorithm obtained better reconstruction quality than other algorithms. It meant that the AFBP-TVM algorithm may be a suitable method for in situ investigation on material's rapid internal microstructure evolution in extreme complex environment.

  12. Elbe flood 2002 in retrospect. Pollution of sediments due to the extreme flood situation around Dresden (Saxony, Germany); Elbehochwasser 2002 - Ein Rueckblick. Schadstoffbelastung von Schlamm- und Sedimentproben im Raum Dresden (Sachsen)

    Energy Technology Data Exchange (ETDEWEB)

    Gruenwald, K.; Unger, C. [Technische Univ. Dresden (Germany). Inst. fuer Geographie; Brauch, H.J.; Schmidt, W. [DVGW-Technologiezentrum Wasser, Karlsruhe (Germany). TZW, Aussenstelle Dresden

    2004-07-01

    Objective: Flood sediments were investigated due to the extreme flood situation around Dresden in August 2002. Methods: The samples have been analyzed by screening inorganic and organic pollutants. Results: It was observed that As, Pb, Cd, Zn, Cu, B and other heavy metals as well as DDT, PCB and Benzo[a]pyren were significantly enriched. Conclusion: Depending on geogenic and anthropogenic impacts the spatial distribution of these contaminants was different. Organic compounds were dislocated downstream from Czech Republic along the Elbe River. Because of the old ore mining, samples near the Mulde and Weisseritz Rivers showed high metal pollution. Perspective: More detailed and systematic investigations should be undertaken in the Elbe and Mulde river systems. (orig.) [German] Ziel/Hintergrund. Neben direkten Schadenswirkungen bei Hochwasserereignissen gibt es zahlreiche indirekte Schaeden, zu denen die Verbreitung von Schadstoffen gehoert. Durch die grossraeumigen Ueberschwemmungen infolge der Sturzfluten und Dammbrueche im August 2002 im Elbegebiet wurden Sedimente und Schlaemme abgelagert, deren Gefahrenpotenzial analysiert und bewertet werden muss. Methoden. Unmittelbar nach dem Hochwasser wurden repraesentative Flutsediment- und Schlammproben aus dem oberen Elbtal und ausgewaehlten Erzgebirgszufluessen auf ein breites Spektrum anorganischer und organischer Schadstoffe untersucht. Ergebnisse. Es wurden teilweise relativ hohe Konzentrationen fuer As, Pb, Cd, Zn, Cu, B sowie DDT, PCB und Benzo[a]pyren festgestellt. Schlussfolgerungen. Geogener Hintergrund und Nutzungscharakteristik der Einzugsgebiete bestimmen das regionale Muster der Belastung. An der Elbe wurden vor allem persistente Organika aus den tschechischen Belastungsraeumen flussabwaerts verlagert. Schwerpunkte der anorganischen Stoffbelastung resultieren aus den erzgebirgischen Bergbaugebieten. Ausblick. Es werden Detailuntersuchungen zur Ermittlung der Gefaehrdungspotenziale an Elbe und Mulde

  13. Radar observations of a tornado-spawning storm complex in Southeast Brazil and Meso-Eta forecasts of this extreme event

    Science.gov (United States)

    Held, Gerhard; Gomes, Jorge Luis; Gomes, Ana Maria

    2014-05-01

    During the early afternoon of 22 September 2013, severe storms, accompanied by large hail, damaging winds, heavy precipitation and intense lightning activity, devastated a region in the southeast State of São Paulo. Several extremely intense storm cells moved at up to 80 km/h east-southeastwards, ahead of a strong cold front approaching through Paraná, which created extremely unstable conditions that led to deep convection and overshooting towers up to 18 km. At least one of theses cells spawned a tornado when it reached the town of Taquarituba. The tornado traversed the town from south-southwest to north-northeast and was responsible for 63 people injured and two fatalities. Based on the damage reported, it was at least an F3 according to the Fujita scale. The objective of the present study is to characterize this severe thunderstorm event, using different types of data, and to evaluate the forecasts provided by the Meso-Eta model centered over Bauru. The pre-frontal and frontal convective cells were tracked throughout their life-time by IPMet's Doppler radars, which cover the western and central regions of the State São Paulo, as well as northern Paraná State. Radar volume scans, generated every 7,5 min, were processed with the TITAN (Thunderstorm Identification, Tracking, Analysis and Nowcasting) Software, yielding the following preliminary results: as the storm complex traversed the Paranapanema River, which forms the border between the two states, the cells intensified drastically and shortly before reaching the town of Taquarituba, that particular cell displayed extremely strong radial shear just above the cloud base (about -20 to +35 m/s), which led to the formation of a deep meso-cyclone, from which the tornado spawned and touched down at around 14:30 LT (LT=UT-3h). Cell properties calculated by TITAN showed a drastic increase of VIL (Vertically Integrated Liquid water content) from 13:52 LT (7,9 kg/m2) to a maximum of 61,8 kg/m2 at 14:15 LT. From 14

  14. Co-operative intra-protein structural response due to protein-protein complexation revealed through thermodynamic quantification: study of MDM2-p53 binding

    Science.gov (United States)

    Samanta, Sudipta; Mukherjee, Sanchita

    2017-09-01

    The p53 protein activation protects the organism from propagation of cells with damaged DNA having oncogenic mutations. In normal cells, activity of p53 is controlled by interaction with MDM2. The well understood p53-MDM2 interaction facilitates design of ligands that could potentially disrupt or prevent the complexation owing to its emergence as an important objective for cancer therapy. However, thermodynamic quantification of the p53-peptide induced structural changes of the MDM2-protein remains an area to be explored. This study attempts to understand the conformational free energy and entropy costs due to this complex formation from the histograms of dihedral angles generated from molecular dynamics simulations. Residue-specific quantification illustrates that, hydrophobic residues of the protein contribute maximum to the conformational thermodynamic changes. Thermodynamic quantification of structural changes of the protein unfold the fact that, p53 binding provides a source of inter-element cooperativity among the protein secondary structural elements, where the highest affected structural elements (α2 and α4) found at the binding site of the protein affects faraway structural elements (β1 and Loop1) of the protein. The communication perhaps involves water mediated hydrogen bonded network formation. Further, we infer that in inhibitory F19A mutation of P53, though Phe19 is important in the recognition process, it has less prominent contribution in the stability of the complex. Collectively, this study provides vivid microscopic understanding of the interaction within the protein complex along with exploring mutation sites, which will contribute further to engineer the protein function and binding affinity.

  15. Stacked Extreme Learning Machines.

    Science.gov (United States)

    Zhou, Hongming; Huang, Guang-Bin; Lin, Zhiping; Wang, Han; Soh, Yeng Chai

    2015-09-01

    Extreme learning machine (ELM) has recently attracted many researchers' interest due to its very fast learning speed, good generalization ability, and ease of implementation. It provides a unified solution that can be used directly to solve regression, binary, and multiclass classification problems. In this paper, we propose a stacked ELMs (S-ELMs) that is specially designed for solving large and complex data problems. The S-ELMs divides a single large ELM network into multiple stacked small ELMs which are serially connected. The S-ELMs can approximate a very large ELM network with small memory requirement. To further improve the testing accuracy on big data problems, the ELM autoencoder can be implemented during each iteration of the S-ELMs algorithm. The simulation results show that the S-ELMs even with random hidden nodes can achieve similar testing accuracy to support vector machine (SVM) while having low memory requirements. With the help of ELM autoencoder, the S-ELMs can achieve much better testing accuracy than SVM and slightly better accuracy than deep belief network (DBN) with much faster training speed.

  16. Complexity

    CERN Document Server

    Gershenson, Carlos

    2011-01-01

    The term complexity derives etymologically from the Latin plexus, which means interwoven. Intuitively, this implies that something complex is composed by elements that are difficult to separate. This difficulty arises from the relevant interactions that take place between components. This lack of separability is at odds with the classical scientific method - which has been used since the times of Galileo, Newton, Descartes, and Laplace - and has also influenced philosophy and engineering. In recent decades, the scientific study of complexity and complex systems has proposed a paradigm shift in science and philosophy, proposing novel methods that take into account relevant interactions.

  17. The complex clinical issues involved in an athlete's decision to retire from collision sport due to multiple concussions: a case study of a professional athlete

    Directory of Open Access Journals (Sweden)

    Andrew eGardner

    2013-09-01

    Full Text Available The issue of retirement from athletic participation due to repetitive concussive injuries remains controversial. The complexity of providing recommendations to elite athletes is highlighted by the prospect that offering inappropriate advice may foreseeably lead to engagement in a medico-legal challenge. Currently no evidenced-based, scientifically validated guidelines for forming the basis of such a decision exist. The current paper discusses the complexities of this challenge in addition to presenting a case study of a professional athlete. A number of central issues to consider when discussing athlete retirement revolve around the player’s medical and concussion histories, the current clinical profile, the athlete’s long-term life goals and understanding of the potential long-terms risks. Ensuring that thorough investigations of all possible differential diagnosis, that may explain the presenting symptoms, are conducted is also essential. Discussion pertaining to recommendations for guiding the clinical approach to the retirement issue for athletes with a history of multiple concussions is presented.

  18. de Sitter Extremal Surfaces

    CERN Document Server

    Narayan, K

    2015-01-01

    We study extremal surfaces in de Sitter space in the Poincare slicing in the upper patch, anchored on spatial subregions at the future boundary ${\\cal I}^+$, restricted to constant boundary Euclidean time slices (focussing on strip subregions). We find real extremal surfaces of minimal area as the boundaries of past lightcone wedges of the subregions in question: these are null surfaces with vanishing area. We find also complex extremal surfaces as complex extrema of the area functional, and the area is not always real-valued. In $dS_4$ the area is real and has some structural resemblance with entanglement entropy in a dual $CFT_3$. There are parallels with analytic continuation from the Ryu-Takayanagi expressions for holographic entanglement entropy in $AdS$. We also discuss extremal surfaces in the $dS$ black brane and the de Sitter "bluewall" studied previously. The $dS_4$ black brane complex surfaces exhibit a real finite cutoff-independent extensive piece. In the bluewall geometry, there are real surface...

  19. Complex

    African Journals Online (AJOL)

    CLEMENT O BEWAJI

    Schiff bases and their complex compounds have been studied for their .... establishing coordination of the N–(2 – hydroxybenzyl) - L - α - valine Schiff base ..... (1967); “Spectrophotometric Identification of Organic Compounds”, Willey, New.

  20. Gender, Education, Extremism and Security

    Science.gov (United States)

    Davies, Lynn

    2008-01-01

    This paper examines the complex relationships between gender, education, extremism and security. After defining extremism and fundamentalism, it looks first at the relationship of gender to violence generally, before looking specifically at how this plays out in more extremist violence and terrorism. Religious fundamentalism is also shown to have…

  1. Extreme heterogeneity of land surface in spring inducing highly complex micrometeorological flow features and heat exchange processes over partly snow covered areas

    Science.gov (United States)

    Mott, Rebecca; Schlögl, Sebastian; Dirks, Lisa; Lehning, Michael

    2017-04-01

    The melting mountain snow cover in spring typically changes from a continuous snow cover to a mosaic of patches of snow and bare ground inducing an extreme heterogeneity of the land surface. Energy balance models typically assume a continuous snow cover, neglecting the complex interaction between the atmospheric boundary layer and the strongly variable surface. We experimentally investigated the small-scale boundary layer dynamics over snow patches and their effect on the energy balance at the snow surface. A comprehensive measurement campaign, the Dischma Experiment, was conducted during three entire ablation periods in spring 2014, 2015 and 2016. The aim of this project is to investigate the boundary layer development and the energy exchange over a melting snow cover with a gradually decreasing snow cover fraction. For this purpose, two measurement towers equipped with five to six ultrasonic anemometers were installed over a long-lasting snow patch. Furthermore, temporally and spatially high resolution ablation rates and snow surface temperatures were determined with a terrestrial laser scanner and an Infrared camera. This data set allows us to relate the spatial patterns of ablation rates and snow surface temperatures to boundary layer dynamics and the changing snow cover fraction. Experimental data reveal that wind conditions, snow cover distribution, local wind fetch distance and topographical curvature control the near-surface boundary layer characteristics and heat exchange processes over snow. The strong heterogeneity of land surface induced by the patchy snow cover caused a high spatial and temporal variability of snow surface temperature and snow melt patterns. Small scale flow features, such as katabatic flows or wind sheltering can be shown to strongly affect the temporal evolution of snow surface patterns. Furthermore, turbulence data reveal a strong correlation of turbulent heat exchange over melting snow with the occurrence of internal thermal

  2. Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect.

    Directory of Open Access Journals (Sweden)

    Kevin R Thornton

    Full Text Available Current genome-wide association studies (GWAS have high power to detect intermediate frequency SNPs making modest contributions to complex disease, but they are underpowered to detect rare alleles of large effect (RALE. This has led to speculation that the bulk of variation for most complex diseases is due to RALE. One concern with existing models of RALE is that they do not make explicit assumptions about the evolution of a phenotype and its molecular basis. Rather, much of the existing literature relies on arbitrary mapping of phenotypes onto genotypes obtained either from standard population-genetic simulation tools or from non-genetic models. We introduce a novel simulation of a 100-kilobase gene region, based on the standard definition of a gene, in which mutations are unconditionally deleterious, are continuously arising, have partially recessive and non-complementing effects on phenotype (analogous to what is widely observed for most Mendelian disorders, and are interspersed with neutral markers that can be genotyped. Genes evolving according to this model exhibit a characteristic GWAS signature consisting of an excess of marginally significant markers. Existing tests for an excess burden of rare alleles in cases have low power while a simple new statistic has high power to identify disease genes evolving under our model. The structure of linkage disequilibrium between causative mutations and significantly associated markers under our model differs fundamentally from that seen when rare causative markers are assumed to be neutral. Rather than tagging single haplotypes bearing a large number of rare causative alleles, we find that significant SNPs in a GWAS tend to tag single causative mutations of small effect relative to other mutations in the same gene. Our results emphasize the importance of evaluating the power to detect associations under models that are genetically and evolutionarily motivated.

  3. Abdominal Skin Flaps in the Repair of 108 Patients with Complex Defects of Upper Extremity%腹部皮瓣修复上肢复杂损伤108例

    Institute of Scientific and Technical Information of China (English)

    王恒; 胡洪良; 沈卫军; 王战磊; 闫纪涛; 龚俊武

    2016-01-01

    well without obvious scars, but with only a few hyperplasia,the function of the upper extremity was basically restored.There was blood supply disturbance of skin flaps appeared in 1 case due to sub skin-flap hematoma,the blood circulation restored after removing part of the suture.2 patients with multiple fingers degloving injury were not so satisfied with the appearance of the operated after restoration,they discharged satisfactorily after two-stage shaping and repairing.The fine motor function of 2 cases with volardorsal compound degloving injury were affected slightly after restoration.There were 96 cases of satisfaction evaluation from the 101 cases,the satisfaction rate was 95.0%.Conclusion:The abdominal skin flaps applies to repairing the complex injury of upper extremity,they are safe and reliable.However,clinical need to strengthen the repair process of nursing,so as to reduce the complications effectively,and improve the patients’ quality of life.

  4. A complex phenotype in a child with familial HDL deficiency due to a novel frameshift mutation in APOA1 gene (apoA-IGuastalla).

    Science.gov (United States)

    Pisciotta, Livia; Vitali, Cecilia; Favari, Elda; Fossa, Paola; Adorni, Maria Pia; Leone, Daniela; Artom, Nathan; Fresa, Raffaele; Calabresi, Laura; Calandra, Sebastiano; Bertolini, Stefano

    2015-01-01

    We describe a kindred with high-density lipoprotein (HDL) deficiency due to APOA1 gene mutation in which comorbidities affected the phenotypic expression of the disorder. An overweight boy with hypertriglyceridemia (HTG) and HDL deficiency (HDL cholesterol 0.39 mmol/L, apoA-I 40 mg/dL) was investigated. We sequenced the candidate genes for HTG (LPL, APOC2, APOA5, GPIHBP1, LMF1) and HDL deficiency (LCAT, ABCA1 and APOA1), analyzed HDL subpopulations, measured cholesterol efflux capacity (CEC) of sera and constructed a model of the mutant apoA-I. No mutations in HTG-related genes, ABCA1 and LCAT were found. APOA1 sequence showed that the proband, his mother and maternal grandfather were heterozygous of a novel frameshift mutation (c.546_547delGC), which generated a truncated protein (p.[L159Afs*20]) containing 177 amino acids with an abnormal C-terminal tail of 19 amino acids. Trace amounts of this protein were detectable in plasma. Mutation carriers had reduced levels of LpA-I, preβ-HDL and large HDL and no detectable HDL-2 in their plasma; their sera had a reduced CEC specifically the ABCA1-mediated CEC. Metabolic syndrome in the proband explains the extremely low HDL cholesterol level (0.31 mmol/L), which was half of that found in the other carriers. The proband's mother and grandfather, both presenting low plasma low-density lipoprotein cholesterol, were carriers of the β-thalassemic trait, a condition known to be associated with a reduced low-density lipoprotein cholesterol and a reduced prevalence of cardiovascular disease. This trait might have delayed the development of atherosclerosis related to HDL deficiency. In these heterozygotes for apoA-I truncation, the metabolic syndrome has deleterious effect on HDL system, whereas β-thalassemia trait may delay the onset of cardiovascular disease. Copyright © 2015 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  5. Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation.

    Directory of Open Access Journals (Sweden)

    Heike Kotarsky

    Full Text Available BACKGROUND & AIMS: Liver is a target organ in many mitochondrial disorders, especially if the complex III assembly factor BCS1L is mutated. To reveal disease mechanism due to such mutations, we have produced a transgenic mouse model with c.232A>G mutation in Bcs1l, the causative mutation for GRACILE syndrome. The homozygous mice develop mitochondrial hepatopathy with steatosis and fibrosis after weaning. Our aim was to assess cellular mechanisms for disease onset and progression using metabolomics. METHODS: With mass spectrometry we analyzed metabolite patterns in liver samples obtained from homozygotes and littermate controls of three ages. As oxidative stress might be a mechanism for mitochondrial hepatopathy, we also assessed H(2O(2 production and expression of antioxidants. RESULTS: Homozygotes had a similar metabolic profile at 14 days of age as controls, with the exception of slightly decreased AMP. At 24 days, when hepatocytes display first histopathological signs, increases in succinate, fumarate and AMP were found associated with impaired glucose turnover and beta-oxidation. At end stage disease after 30 days, these changes were pronounced with decreased carbohydrates, high levels of acylcarnitines and amino acids, and elevated biogenic amines, especially putrescine. Signs of oxidative stress were present in end-stage disease. CONCLUSIONS: The findings suggest an early Krebs cycle defect with increases of its intermediates, which might play a role in disease onset. During disease progression, carbohydrate and fatty acid metabolism deteriorate leading to a starvation-like condition. The mouse model is valuable for further investigations on mechanisms in mitochondrial hepatopathy and for interventions.

  6. 儿童双骨肢体单骨骨折对关节的影响%Influence on Joints Due to Fracture of Single Bone on Double Bone Extremities in Children

    Institute of Scientific and Technical Information of China (English)

    俞志涛; 王承武; 范源

    1997-01-01

    Objective:To observe the overgrowth after the fracture of a single bone in double bone extremities in children.Methods:179 cases of forearm fracture and 123 of lower leg fracture (excluding Monteggia fracture,Galeazzi fracture or physeal injuries)were reviewed.The time of follow-up was 5~8 years(mean 7.5 years).Comparative assessments of bilateral extremities on X-ray examination included length of ulna and radius,radioulnar angle,anteversion of the radius,radiocapitular line,position of the capitellium,length of the tibia and fibula,and anteroposteriorproject of the ankle.Ranges of motion of the wrist,elbow,forearm and ankle were examined.Results:Overgrowth of affected bones With 2~4 mm in length were found only in 4 cases of forearm fracture and in 7 cases of lower leg fracture.Conclusions:In most cases of fracture of singlebone on double bone extremities,overgrowth of affected bone has been rarely observed.%目的:为了观察儿童双骨肢体单骨骨折后的过度生长.方法:对前臂单骨骨折179例(不包括孟氏骨折、盖氏骨折及骨骺损伤),小腿单骨骨折123例(不包括骨骺损伤),进行了5~6年的随访,平均7.5年.对比测量了双侧X线片中的尺、桡骨长度、胫腓骨长度、桡尺角、桡骨内倾角、桡骨头线、肱骨小头的位置以及踝关节正位片,并对腕、肘关节、踝关节活动进行了对比.结果:前臂有4例,小腿有7例较对侧长2~4 mm.前臂、腕、肘关节及踝关节活动无异常.结论:前臂是双骨均衡支撑肢体,小腿虽以胫骨负重为主,但单骨骨折后另一骨同样可起支撑作用,因此均不会出现明显的过度生长.

  7. Deformations of extremal toric manifolds

    CERN Document Server

    Rollin, Yann

    2012-01-01

    Let $X$ be a compact toric extremal K\\"ahler manifold. Using the work of Sz\\'ekelyhidi, we provide a simple criterion on the fan describing $X$ to ensure the existence of complex deformations of $X$ that carry extremal metrics. As an example, we find new CSC metrics on 4-points blow-ups of $\\C\\P^1\\times\\C\\P^1$.

  8. Genetic diversity and geographic structure in Aglaia elaeagnoidea (Meliaceae, Sapindales), a morphologically complex tree species, near the two extremes of its distribution

    NARCIS (Netherlands)

    Muellner, A.N.; Greger, H.; Pannell, C.M.

    2009-01-01

    Aglaia elaeagnoidea is the most widespread and one of the more morphologically diverse complex species in the largest genus of the mahogany family (Meliaceae, Sapindales). We performed maximum parsimony, maximum likelihood and Bayesian analyses (nuclear ITS rDNA) to estimate genetic relations among

  9. A computational study of structural and magnetic properties of bi- and trinuclear Cu(II) complexes with extremely long Cu-Cu distances

    Science.gov (United States)

    Baryshnikov, Gleb V.; Minaev, Boris F.; Baryshnikova, Alina T.; Ågren, Hans

    2017-07-01

    Three recently synthesized copper(II) complexes with aroylhydrazones of trifluoroacetic and benzenecarboxylic acids (Dalton Trans., 2013, 42, 16878) have been computationally investigated by density functional theory within the broken symmetry approximation accounting for empirical dispersion corrections. A topological analysis of electron density distributions has been carried out using Bader's ;quantum theory of atoms in molecules; formalism. The calculated values of spin-spin exchange for the studied dinuclear complexes indicate a very weak ferromagnetic coupling of the unpaired electrons in good agreement with experimental data. At the same time, the trinuclear copper(II) complex possesses a low-spin doublet ground state with one ferromagnetic and two antiferromagnetic spin projections between the triangular-positioned Cu2+ ions. The estimated values of the coupling constants for the spin-spin exchange in this trinuclear complex are in a good agreement with experimental observations. The calculations support a mechanism of exchange coupling through the aromatic links in these strongly spin-separated systems.

  10. Situações limite decorrentes da violência de gênero Situações limite decorrentes da violência de gênero Extreme situations due to gender violence

    Directory of Open Access Journals (Sweden)

    Stela Meneghel

    2012-11-01

    Full Text Available

    Este texto apresenta uma síntese do Seminário Rotas Críticas III, realizado em Porto Alegre/Brasil, em 2011, cujo foco foi situações limite da violência de gênero. As situações limite são violações de direitos humanos que incluem os femicídios ou assassinatos motivados pela situação de gênero; assassinatos de pessoas LGBT, violações a direitos de minorias étnicas e raciais, exploração sexual, violências a mulheres em situação de vulnerabilidade e outras violências decorrentes de gênero. O objetivo do encontro foi oportunizar espaço para partilhar experiências, refletir criticamente e construir estratégias para o enfrentamento de violências e situações limite decorrentes de sistemas de gênero.

     

    Este texto apresenta uma síntese do Seminário Rotas Críticas III, realizado em Porto Alegre/Brasil, em 2011, cujo foco foi situações limite da violência de gênero. As situações limite são violações de direitos humanos que incluem os femicídios ou assassinatos motivados pela situação de gênero; assassinatos de pessoas LGBT, violações a direitos de minorias étnicas e raciais, exploração sexual, violências a mulheres em situação de vulnerabilidade e outras violências decorrentes de gênero. O objetivo do encontro foi oportunizar espaço para partilhar experiências, refletir criticamente e construir estratégias para o enfrentamento de violências e situações limite decorrentes de sistemas de gênero.

    This paper presents a synthesis of the third Critical Paths Seminar, held in Porto Alegre/Brazil in 2011, whose focus was extreme situations of gender violence. The extreme situations are human rights violations that include femicide or murder motivated by the situation of gender; LGBT murders, human rights violations of ethnic and racial minorities, sexual exploitation, violence to women in vulnerable situations

  11. Extremely fast increase in the organic loading rate during the co-digestion of rapeseed oil and sewage sludge in a CSTR--characterization of granules formed due to CaO addition to maintain process stability.

    Science.gov (United States)

    Kasina, M; Kleyböcker, A; Michalik, M; Würdemann, H

    2015-01-01

    In a co-digestion system running with rapeseed oil and sewage sludge, an extremely fast increase in the organic loading rate was studied to develop a procedure to allow for flexible and demand-driven energy production. The over-acidification of the digestate was successfully prevented by calcium oxide dosage, which resulted in granule formation. Mineralogical analyses revealed that the granules were composed of insoluble salts of long chain fatty acids and calcium and had a porous structure. Long chain fatty acids and calcium formed the outer cover of granules and offered interfaces on the inside thereby enhancing the growth of biofilms. With granule size and age, the pore size increased and indicated degradation of granular interfaces. A stable biogas production up to the organic loading rate of 10.4 kg volatile solids m(-3) d(-1) was achieved although the hydrogen concentration was not favorable for propionic acid degradation. However, at higher organic loading rates, unbalanced granule formation and degradation were observed. Obviously, the adaption time for biofilm growth was too short to maintain the balance, thereby resulting in a low methane yield.

  12. Genetic diversity and geographic structure in Aglaia elaeagnoidea (Meliaceae, Sapindales), a morphologically complex tree species, near the two extremes of its distribution

    OpenAIRE

    2009-01-01

    Aglaia elaeagnoidea is the most widespread and one of the more morphologically diverse complex species in the largest genus of the mahogany family (Meliaceae, Sapindales). We performed maximum parsimony, maximum likelihood and Bayesian analyses (nuclear ITS rDNA) to estimate genetic relations among samples of Aglaia elaeagnoidea, and their phylogenetic position within Aglaia (more than 120 species in Indomalesia, Australasia, and the Pacific islands). Based on 90 accessions of Melioideae (ing...

  13. Binding of hydrocarbons and other extremely weak ligands to transition metal complexes that coordinate hydrogen: Investigation of cis-interactions and delocalized bonding involving sigma bonds

    Energy Technology Data Exchange (ETDEWEB)

    Kubas, G.J.; Eckert, J.; Luo, X.L. [and others

    1997-07-01

    This is the final report of a three-year Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). At the forefront of chemistry are efforts to catalytically transform the inert C-H bonds in alkanes to more useful products using metal compounds. The goal is to observe binding and cleavage of alkane C-H bonds on metals or to use related silane Si-H bonding as models, analogous to the discovery of hydrogen (H{sub 2}) binding to metals. Studies of these unique sigma complexes (M{hor_ellipsis}H-Y; Y{double_bond}H, Si, C) will aid in developing new catalysts or technologies relevant to DOE interest, e.g., new methods for tritium isotope separation. Several transition metals (Mo, W, Mn, and Pt) were found to reversibly bind and cleave H{sub 2}, silanes, and halocarbons. The first metal-SiH{sub 4} complexes, thus serving as a model for methane reactions. A second goal is to study the dynamics and energetics of H-Y bonds on metals by neutron scattering, and evidence for interactions between bound H-Y and nearby H atoms on metal complexes has been found.

  14. Metagenomics of extreme environments.

    Science.gov (United States)

    Cowan, D A; Ramond, J-B; Makhalanyane, T P; De Maayer, P

    2015-06-01

    Whether they are exposed to extremes of heat or cold, or buried deep beneath the Earth's surface, microorganisms have an uncanny ability to survive under these conditions. This ability to survive has fascinated scientists for nearly a century, but the recent development of metagenomics and 'omics' tools has allowed us to make huge leaps in understanding the remarkable complexity and versatility of extremophile communities. Here, in the context of the recently developed metagenomic tools, we discuss recent research on the community composition, adaptive strategies and biological functions of extremophiles.

  15. Interfacing a haptic robotic system with complex virtual environments to treat impaired upper extremity motor function in children with cerebral palsy

    Science.gov (United States)

    FLUET, GERARD G.; QIU, QINYIN; KELLY, DONNA; PARIKH, HETA D.; RAMIREZ, DIEGO; SALEH, SOHA; ADAMOVICH, SERGEI V.

    2011-01-01

    Objective To investigate the ability of the New Jersey Institute of Technology Robot Assisted Virtual Rehabilitation (NJIT-RAVR) system training to elicit changes in upper extremity (UE) function in children with hemiplegia secondary to cerebral palsy. Methods Nine children (mean age 9 years, three males) participated in three pilots. Subjects trained 1 hour, 3 days a week for 3 weeks. Two groups performed this protocol as their only intervention. The third group also performed 5–6 hours of constraint-induced movement therapy. Results All subjects participated in a short programme of nine, 60-minute training sessions without adverse effects. As a group, subjects demonstrated statistically significant improvements in Melbourne Assessment of Unilateral Upper Limb Function Test, a composite of three timed UE tasks and several measurements of reaching kinematics. Several subjects demonstrated clinically significant improvements in active shoulder abduction and flexion as well as forearm supination. Conclusion Three small pilots of NJIT-RAVR training demonstrated measurable benefit with no complications, warranting further examination. PMID:20828330

  16. Evolution of the C2RCC Neural Network for Sentinel 2 and 3 for the Retrieval of Ocean Colour Products in Normal and Extreme Optically Complex Waters

    Science.gov (United States)

    Brockmann, Carsten; Doerffer, Roland; Peters, Marco; Kerstin, Stelzer; Embacher, Sabine; Ruescas, Ana

    2016-08-01

    Retrieval of water constituents, or its optical properties, requires inversion of the water leaving reflectance spectrum, measured at top of atmosphere by ocean colour satellites. The Case 2 Regional processor, originally developed by Doerffer and Schiller [6], uses a large database of radiative transfer simulations inverted by neural networks as basic technology. Through the CoastColour project major improvements were introduced. It has been amended by a set of additional neural networks performing specific tasks and special neural networks have been trained to cover extreme ranges of scattering and absorption. The processor has been renamed into C2RCC (Case 2 Regional CoastColour) and is applicable to all past and current ocean colour sensors as well as Sentinel 2. It has been validated in various studies and is available through ESA's Sentinel toolbox SNAP. It is also used in the Sentinel 3 OLCI ground segment processor of ESA for the generation of the Case 2 water products, as well as in the processor for the upcoming MERIS 4th reprocessing.

  17. Complex self-assembly of reverse poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) triblock copolymers with long hydrophobic and extremely lengthy hydrophilic blocks.

    Science.gov (United States)

    Cambón, Adriana; Figueroa-Ochoa, Edgar; Juárez, Josué; Villar-Álvarez, Eva; Pardo, Alberto; Barbosa, Silvia; Soltero, J F Armando; Taboada, Pablo; Mosquera, Víctor

    2014-05-15

    Amphiphilic block copolymers have emerged during last years as a fascinating substrate material to develop micellar nanocontainers able to solubilize, protect, transport, and release under external or internal stimuli different classes of cargos to diseased cells or tissues. However, this class of materials can also induce biologically relevant actions, which complement the therapeutic activity of their cargo molecules through their mutual interactions with biologically relevant entities (cellular membranes, proteins, organelles...); these interactions at the same time, are regulated by the nature, conformation, and state of the copolymeric chains. For these reasons, in this paper we investigated the self-assembly process and physico-chemcial properties of two reverse triblock poly(butylene oxide)-poly(ethylene oxide)-poly(butylene oxide) block copolymers, BO14EO378BO14 and BO21EO385BO21, which have been recently found to be very useful as drug delivery nanovehicles and biological response modifiers under certain conditions (A. Cambón et al. Int. J. Pharm. 2013, 445, 47-57) in order to obtain a clear picture of the solution behavior of this class or block copolymers and to understand their biological activity. These block copolymers are characterized by possessing long BO blocks and extremely lengthy central EO ones, which provide them with a rich rheological behavior characterized by the formation of flowerlike micelles with sizes ranging from 20 to 40 nm in aqueous solution and the presence of intermicellar bridging even at low copolymers concentrations as denoted by atomic force microscopy. Bridging is also clearly observed by analyzing the rheological response of these block copolymers both storage and loss moduli upon changes on time, temperature, and or concentration. Strikingly, the relatively wide Poisson distribution of the polymeric chains make the present copolymers behave rather distinctly to conventional associative thickeners. The observed rich

  18. Size polymorphism of chicken major histocompatibility complex-encoded B-G molecules is due to length variation in the cytoplasmic heptad repeat region

    DEFF Research Database (Denmark)

    Kaufman, J; Salomonsen, J; Skjødt, K

    1990-01-01

    B-G antigens are cell-surface molecules encoded by a highly polymorphic multigene family located in the chicken major histocompatibility complex (MHC). Rabbit antisera to B-G molecules immunoprecipitate 3-6 bands from iodinated erythrocytes by sodium dodecyl sulfate (SDS) gels under reducing...

  19. Wind Turbine Extreme Gust Control. Recognition and Control of extreme operation gusts and wind direction changes

    Energy Technology Data Exchange (ETDEWEB)

    Kanev, S.K.; Van Engelen, T.G. [ECN Wind Energy, Petten (Netherlands)

    2008-10-15

    This report presents the research activities and achieved results on extreme event recognition (EER) and control (EEC). This work has been performed within the framework of WP3 of the SenterNovem project Sustainable Control (SusCon). An extreme wind gust with direction change can lead to large loads on the turbine (causing fatigue) and unnecessary turbine shut-downs by the supervisory system due to rotor overspeed. The proposed EER algorithm is based on a nonlinear observer (extended Kalman filter) that estimates the oblique wind inflow angle and the blade effective wind speed signals, which are then used by a detection algorithm (CUSUM test) to recognize extreme events. The nonlinear observer requires that blade root bending moments measurements (in-plane and out-of-plane) are available. Once an extreme event is detected, an EEC algorithm is activated that (1) tries to prevent the rotor speed from exceeding the overspeed limit by fast collective blade pitching, and (2) reduces 1p blade loads by means of individual pitch control algorithm, designed in an H1 optimal control setting. The method is demonstrated on a complex nonlinear test turbine model.

  20. Size polymorphism of chicken major histocompatibility complex-encoded B-G molecules is due to length variation in the cytoplasmic heptad repeat region

    DEFF Research Database (Denmark)

    Kaufman, J; Salomonsen, J; Skjødt, K;

    1990-01-01

    that the extracellular regions of these molecules are very similar and that the length polymorphism is due to variations in the cytoplasmic regions. Inspection of the cDNA-derived protein sequence in this region shows many heptad repeats, which may allow variation in length by step deletion and alternative splicing...

  1. Narcolepsy: Autoimmunity, Effector T Cell Activation Due to Infection, or T Cell Independent, Major Histocompatibility Complex Class II Induced Neuronal Loss?

    Science.gov (United States)

    Fontana, Adriano; Gast, Heidemarie; Reith, Walter; Recher, Mike; Birchler, Thomas; Bassetti, Claudio L.

    2010-01-01

    Human narcolepsy with cataplexy is a neurological disorder, which develops due to a deficiency in hypocretin producing neurons in the hypothalamus. There is a strong association with human leucocyte antigens HLA-DR2 and HLA-DQB1*0602. The disease typically starts in adolescence. Recent developments in narcolepsy research support the hypothesis of…

  2. Narcolepsy: Autoimmunity, Effector T Cell Activation Due to Infection, or T Cell Independent, Major Histocompatibility Complex Class II Induced Neuronal Loss?

    Science.gov (United States)

    Fontana, Adriano; Gast, Heidemarie; Reith, Walter; Recher, Mike; Birchler, Thomas; Bassetti, Claudio L.

    2010-01-01

    Human narcolepsy with cataplexy is a neurological disorder, which develops due to a deficiency in hypocretin producing neurons in the hypothalamus. There is a strong association with human leucocyte antigens HLA-DR2 and HLA-DQB1*0602. The disease typically starts in adolescence. Recent developments in narcolepsy research support the hypothesis of…

  3. Forest operations, extreme flooding events, and considerations for hydrologic modeling in the Appalachians--A review

    Science.gov (United States)

    M.A. Eisenbies; W.M. Aust; J.A. Burger; M.B. Adams

    2007-01-01

    The connection between forests and water resources is well established, but the relationships among controlling factors are only partly understood. Concern over the effects of forestry operations, particularly harvesting, on extreme flooding events is a recurrent issue in forest and watershed management. Due to the complexity of the system, and the cost of installing...

  4. Extremely Preterm Birth

    Science.gov (United States)

    ... Events Advocacy For Patients About ACOG Extremely Preterm Birth Home For Patients Search FAQs Extremely Preterm Birth ... Spanish FAQ173, June 2016 PDF Format Extremely Preterm Birth Pregnancy When is a baby considered “preterm” or “ ...

  5. A complex form of hereditary spastic paraplegia in three siblings due to somatic mosaicism for a novel SPAST mutation in the mother.

    Science.gov (United States)

    Aulitzky, Anna; Friedrich, Katrin; Gläser, Dieter; Gastl, Regina; Kubisch, Christian; Ludolph, Albert C; Volk, Alexander E

    2014-12-15

    Hereditary spastic paraplegias (HSPs) represent a clinically and genetically heterogeneous group of diseases. Major symptoms comprise progressive bilateral leg stiffness, spasticity at rest and diffuse muscle weakness. Complex forms are characterized by additional symptoms like dementia, cerebellar dysfunction or seizures. Autosomal dominant, autosomal recessive, X-linked recessive and possibly mitochondrial inheritance have been described in familial HSP. The most frequently mutated gene in familial cases of uncomplicated autosomal dominant HSP is SPAST, however de novo mutations in SPAST are rarely found. Here, we report on the clinical and genetic findings in a family with three children afflicted by complex HSP and their unaffected parents. Although autosomal dominant inheritance seemed unlikely in this family, genetic testing revealed a novel SPAST mutation, c.1837G>C (p.Asp613His), in a heterozygous state in all affected individuals and somatic mosaicism of this mutation in the unaffected mother. Our study thus expands the knowledge on SPAST-associated HSP and emphasizes that de novo mutations and somatic mosaicism should be taken into consideration in HSP families presenting with a family history not suggestive for an autosomal dominant inheritance pattern.

  6. Contradiction between plastid gene transcription and function due to complex posttranscriptional splicing: an exemplary study of ycf15 function and evolution in angiosperms.

    Directory of Open Access Journals (Sweden)

    Chao Shi

    Full Text Available Plant chloroplast genes are usually co-transcribed while its posttranscriptional splicing is fairly complex and remains largely unsolved. On basis of sequencing the three complete Camellia (Theaceae chloroplast genomes for the first time, we comprehensively analyzed the evolutionary patterns of ycf15, a plastid gene quite paradoxical in terms of its function and evolution, along the inferred angiosperm phylogeny. Although many species in separate lineages including the three species reported here contained an intact ycf15 gene in their chloroplast genomes, the phylogenetic mixture of both intact and obviously disabled ycf15 genes imply that they are all non-functional. Both intracellular gene transfer (IGT and horizontal gene transfer (HGT failed to explain such distributional anomalies. While, transcriptome analyses revealed that ycf15 was transcribed as precursor polycistronic transcript which contained ycf2, ycf15 and antisense trnL-CAA. The transcriptome assembly was surprisingly found to cover near the complete Camellia chloroplast genome. Many non-coding regions including pseudogenes were mapped by multiple transcripts, indicating the generality of pseudogene transcriptions. Our results suggest that plastid DNA posttranscriptional splicing may involve complex cleavage of non-functional genes.

  7. A novel adaptive method for the analysis of next-generation sequencing data to detect complex trait associations with rare variants due to gene main effects and interactions.

    Directory of Open Access Journals (Sweden)

    Dajiang J Liu

    2010-10-01

    Full Text Available There is solid evidence that rare variants contribute to complex disease etiology. Next-generation sequencing technologies make it possible to uncover rare variants within candidate genes, exomes, and genomes. Working in a novel framework, the kernel-based adaptive cluster (KBAC was developed to perform powerful gene/locus based rare variant association testing. The KBAC combines variant classification and association testing in a coherent framework. Covariates can also be incorporated in the analysis to control for potential confounders including age, sex, and population substructure. To evaluate the power of KBAC: 1 variant data was simulated using rigorous population genetic models for both Europeans and Africans, with parameters estimated from sequence data, and 2 phenotypes were generated using models motivated by complex diseases including breast cancer and Hirschsprung's disease. It is demonstrated that the KBAC has superior power compared to other rare variant analysis methods, such as the combined multivariate and collapsing and weight sum statistic. In the presence of variant misclassification and gene interaction, association testing using KBAC is particularly advantageous. The KBAC method was also applied to test for associations, using sequence data from the Dallas Heart Study, between energy metabolism traits and rare variants in ANGPTL 3,4,5 and 6 genes. A number of novel associations were identified, including the associations of high density lipoprotein and very low density lipoprotein with ANGPTL4. The KBAC method is implemented in a user-friendly R package.

  8. Fungal Peritonitis Due to Fusarium solani Species Complex Sequential Isolates Identified with DNA Sequencing in a Kidney Transplant Recipient in Brazil.

    Science.gov (United States)

    da Silva-Rocha, Walicyranison Plinio; Zuza-Alves, Diana Luzia; Melo, Analy Salles de Azevedo; Chaves, Guilherme Maranhão

    2015-12-01

    Fungal peritonitis is a rare serious complication most commonly observed in immunocompromised patients under peritoneal dialysis. Nevertheless, this clinical condition is more difficult to treat than bacterial peritonitis. Bacterial peritonitis followed by the use of antibiotics is the main risk factor for developing fungal peritonitis. Candida spp. are more frequently isolated, and the isolation of filamentous fungi is only occasional. Here we describe a case of Fusarium solani species complex peritonitis associated with bacterial peritonitis in a female kidney transplant recipient with previous history of nephrotic syndrome. The patient has had Enterobacter sp. endocarditis and was hypertensive and diabetic. Two sequential isolates of F. solani were recovered from cultures and identified with different molecular techniques. She was successfully treated with 50 mg daily amphotericin B for 4 weeks.

  9. Planck cold clumps in the $\\lambda$ Orionis complex: I. Discovery of an extremely young Class 0 protostellar object and a proto-brown dwarf candidate in a bright rimmed clump PGCC G192.32-11.88

    CERN Document Server

    Liu, Tie; Kim, Kee-Tae; Wu, Yuefang; Lee, Chang Won; Lee, Jeong-Eun; Tatematsu, Kenichi; Choi, Minho; Juvela, Mika; Thompson, Mark; Goldsmith, Paul F; Liu, Sheng-yuan; Naomi, Hirano; Koch, Patrick; Henkel, Christian; Sanhueza, Patricio; He, JinHua; Rivera-Ingraham, Alana; Wang, Ke; Cunningham, Maria R; Tang, Ya-Wen; Lai, Shih-Ping; Yuan, Jinghua; Li, Di; Fuller, Gary; Kang, Miju; Luong, Quang Nguyen; Liu, Hauyu Baobab; Ristorcelli, Isabelle; Yang, Ji; Xu, Ye; Hirota, Tomoya; Mardones, Diego; Qin, Sheng-Li; Chen, Huei-Ru; Kwon, Woojin; Meng, FanYi; Zhang, Huawei; Kim, Mi-Ryang; Yi, Hee-Weon

    2015-01-01

    We are performing a series of observations with ground-based telescopes toward Planck Galactic cold clumps (PGCCs) in the $\\lambda$ Orionis complex in order to systematically investigate the effects of stellar feedback. In the particular case of PGCC G192.32-11.88, we discovered an extremely young Class 0 protostellar object (G192N) and a proto-brown dwarf candidate (G192S). G192N and G192S are located in a gravitationally bound bright-rimmed clump. The velocity and temperature gradients seen in line emission of CO isotopologues indicate that PGCC G192.32-11.88 is externally heated and compressed. G192N probably has the lowest bolometric luminosity ($\\sim0.8$ L$_{\\sun}$) and accretion rate (6.3$\\times10^{-7}$ M$_{\\sun}$~yr$^{-1}$) when compared with other young Class 0 sources (e.g. PACS Bright Red sources (PBRs)) in the Orion complex. It has slightly larger internal luminosity ($0.21\\pm0.01$ L$_{\\sun}$) and outflow velocity ($\\sim$14 km~s$^{-1}$) than the predictions of first hydrostatic cores (FHSCs). G192N...

  10. Multidimensional extremal dependence coefficients

    OpenAIRE

    2017-01-01

    Extreme values modeling has attracting the attention of researchers in diverse areas such as the environment, engineering, or finance. Multivariate extreme value distributions are particularly suitable to model the tails of multidimensional phenomena. The analysis of the dependence among multivariate maxima is useful to evaluate risk. Here we present new multivariate extreme value models, as well as, coefficients to assess multivariate extremal dependence.

  11. The European Extreme Right and Religious Extremism

    Directory of Open Access Journals (Sweden)

    Jean-Yves Camus

    2007-12-01

    Full Text Available The ideology of the Extreme Right in Western Europe is rooted in Catholic fundamentalism and Counter-Revolutionary ideas. However, the Extreme Right, like all other political families, has had to adjust to an increasingly secular society. The old link between religion and the Extreme Right has thus been broken and in fact already was when Fascism overtook Europe: Fascism was secular, sometimes even anti-religious, in its essence. Although Catholic fundamentalists still retain strong positions within the apparatus of several Extreme Right parties (Front National, the vote for the Extreme Right is generally weak among regular churchgoers and strong among non-believers. In several countries, the vote for the Extreme Right is stronger among Protestant voters than among Catholics, since while Catholics may support Christian-Democratic parties, there are very few political parties linked to Protestant churches. Presently, it also seems that Paganism is becoming the dominant religious creed within the Extreme Right. In a multicultural Europe, non-Christian forms of religious fundamentalism such as Islamism also exist with ideological similarities to the Extreme Right, but this is not sufficient to categorize Islamism as a form of Fascism. Some Islamist groups seek alliances with the Extreme Right on the basis of their common dislike for Israel and the West, globalization and individual freedom of thought.

  12. Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex.

    Science.gov (United States)

    Dutta, Arijit; Eckelmann, Bradley; Adhikari, Sanjay; Ahmed, Kazi Mokim; Sengupta, Shiladitya; Pandey, Arvind; Hegde, Pavana M; Tsai, Miaw-Sheue; Tainer, John A; Weinfeld, Michael; Hegde, Muralidhar L; Mitra, Sankar

    2017-03-17

    Microhomology-mediated end joining (MMEJ), an error-prone pathway for DNA double-strand break (DSB) repair, is implicated in genomic rearrangement and oncogenic transformation; however, its contribution to repair of radiation-induced DSBs has not been characterized. We used recircularization of a linearized plasmid with 3΄-P-blocked termini, mimicking those at X-ray-induced strand breaks, to recapitulate DSB repair via MMEJ or nonhomologous end-joining (NHEJ). Sequence analysis of the circularized plasmids allowed measurement of relative activity of MMEJ versus NHEJ. While we predictably observed NHEJ to be the predominant pathway for DSB repair in our assay, MMEJ was significantly enhanced in preirradiated cells, independent of their radiation-induced arrest in the G2/M phase. MMEJ activation was dependent on XRCC1 phosphorylation by casein kinase 2 (CK2), enhancing XRCC1's interaction with the end resection enzymes MRE11 and CtIP. Both endonuclease and exonuclease activities of MRE11 were required for MMEJ, as has been observed for homology-directed DSB repair (HDR). Furthermore, the XRCC1 co-immunoprecipitate complex (IP) displayed MMEJ activity in vitro, which was significantly elevated after irradiation. Our studies thus suggest that radiation-mediated enhancement of MMEJ in cells surviving radiation therapy may contribute to their radioresistance and could be therapeutically targeted. © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research.

  13. Linkage Study Revealed Complex Haplotypes in a Multifamily due to Different Mutations in CAPN3 Gene in an Iranian Ethnic Group.

    Science.gov (United States)

    Mojbafan, Marzieh; Tonekaboni, Seyed Hassan; Abiri, Maryam; Kianfar, Soudeh; Sarhadi, Ameneh; Nilipour, Yalda; Tavakkoly-Bazzaz, Javad; Zeinali, Sirous

    2016-07-01

    Calpainopathy is an autosomal recessive form of limb girdle muscular dystrophies which is caused by mutation in CAPN3 gene. In the present study, co-segregation of this disorder was analyzed with four short tandem repeat markers linked to the CAPN3 gene. Three apparently unrelated Iranian families with same ethnicity were investigated. Haplotype analysis and sequencing of the CAPN3 gene were performed. DNA sample from one of the patients was simultaneously sent for next-generation sequencing. DNA sequencing identified two mutations. It was seen as a homozygous c.2105C>T in exon 19 in one family, a homozygous novel mutation c.380G>A in exon 3 in another family, and a compound heterozygote form of these two mutations in the third family. Next-generation sequencing also confirmed our results. It was expected that, due to the rare nature of limb girdle muscular dystrophies, affected individuals from the same ethnic group share similar mutations. Haplotype analysis showed two different homozygote patterns in two families, yet a compound heterozygote pattern in the third family as seen in the mutation analysis. This study shows that haplotype analysis would help in determining presence of different founders.

  14. False-positive myeloperoxidase binding activity due to DNA/anti-DNA antibody complexes: a source for analytical error in serologic evaluation of anti-neutrophil cytoplasmic autoantibodies.

    Science.gov (United States)

    Jethwa, H S; Nachman, P H; Falk, R J; Jennette, J C

    2000-09-01

    Anti-myeloperoxidase antibodies (anti-MPO) are a major type of anti-neutrophil cytoplasmic antibody (ANCA). While evaluating anti-MPO monoclonal antibodies from SCG/Kj mice, we observed several hybridomas that appeared to react with both MPO and DNA. Sera from some patients with systemic lupus erythematosus (SLE) also react with MPO and DNA. We hypothesized that the MPO binding activity is a false-positive result due to the binding of DNA, contained within the antigen binding site of anti-DNA antibodies, to the cationic MPO. Antibodies from tissue culture supernatants from 'dual reactive' hybridomas were purified under high-salt conditions (3 M NaCl) to remove any antigen bound to antibody. The MPO and DNA binding activity were measured by ELISA. The MPO binding activity was completely abrogated while the DNA binding activity remained. The MPO binding activity was restored, in a dose-dependent manner, by the addition of increasing amount of calf-thymus DNA (CT-DNA) to the purified antibody. Sera from six patients with SLE that reacted with both MPO and DNA were treated with DNase and showed a decrease in MPO binding activity compared with untreated samples. MPO binding activity was observed when CT-DNA was added to sera from SLE patients that initially reacted with DNA but not with MPO. These results suggest that the DNA contained within the antigen binding site of anti-DNA antibodies could bind to the highly cationic MPO used as substrate antigen in immunoassays, resulting in a false-positive test.

  15. Proposal of Enhanced Extreme Programming Model

    Directory of Open Access Journals (Sweden)

    M. Rizwan Jameel Qureshi

    2015-01-01

    Full Text Available Extreme programming is one of the commonly used agile methodologies in software development. It is very responsive to changing requirements even in the late phases of the project. However, quality activities in extreme programming phases are implemented sequentially along with the activities that work on the functional requirements. This reduces the agility to deliver increments continuously and makes an inverse relationship between quality and agility. Due to this relationship, extreme programming does not consume enough time on making extensive documentation and robust design. To overcome these issues, an enhanced extreme programming model is proposed. Enhanced extreme programming introduces parallelism in the activities' execution through putting quality activities into a separate execution line. In this way, the focus on delivering increments quickly is achieved without affecting the quality of the final output. In enhanced extreme programming, the quality concept is extended to include refinement of all phases of classical extreme programming and creating architectural design based on the refined design documents.

  16. Deficiently Extremal Cohen-Macaulay Algebras

    Indian Academy of Sciences (India)

    Chanchal Kumar; Pavinder Singh

    2010-04-01

    The aim of this paper is to study homological properties of deficiently extremal Cohen–Macaulay algebras. Eagon–Reiner showed that the Stanley–Reisner ring of a simplicial complex has a linear resolution if and only if the Alexander dual of the simplicial complex is Cohen–Macaulay. An extension of a special case of Eagon–Reiner theorem is obtained for deficiently extremal Cohen–Macaulay Stanley–Reisner rings.

  17. Extreme precipitation and extreme streamflow in the Dongjiang River Basin in southern China

    Directory of Open Access Journals (Sweden)

    W. Wang

    2007-07-01

    Full Text Available Extreme hydro-meteorological events have become the focus of more and more studies in the last decade. Due to the complexity of the spatial pattern of changes in precipitation processes, it is still hard to establish a clear view of how precipitation has changed and how it will change in the future. In the present study, changes in extreme precipitation and streamflow processes in the Dongjiang River Basin in southern China are investigated. It was shown that little change is observed in annual extreme precipitation in terms of various indices, but some significant changes are found in the precipitation processes on a monthly basis. The result indicates that when detecting climate changes, besides annual indices, seasonal variations in extreme events should be considered as well. Despite of little change in annual extreme precipitation series, significant changes are detected in several annual extreme flood flow and low-flow series, mainly at the stations along the main channel of Dongjiang River, which are affected significantly by the operation of several major reservoirs. The result highlights the importance of evaluating the impacts of human activities in assessing the changes of extreme streamflows. In addition, three non-parametric methods that are not-commonly used by hydro-meteorology community, i.e., Kolmogorov–Smirnov test, Levene's test and quantile test, are introduced and assessed by Monte Carlo simulation in the present study to test for changes in the distribution, variance and the shift of tails of different groups of dataset. Monte Carlo simulation result shows that, while all three methods work well for detecting changes in two groups of data with large data size (e.g., over 200 points in each group and big difference in distribution parameters (e.g., over 100% increase of scale parameter in Gamma distribution, none of them are powerful enough for small data sets (e.g., less than 100 points and small distribution

  18. Legacy to the extreme

    NARCIS (Netherlands)

    A. van Deursen (Arie); T. Kuipers (Tobias); L.M.F. Moonen (Leon)

    2000-01-01

    textabstractWe explore the differences between developing a system using extreme programming techniques, and maintaining a legacy system. We investigate whether applying extreme programming techniques to legacy maintenance is useful and feasible.

  19. Legacy to the extreme

    NARCIS (Netherlands)

    Deursen, A. van; Kuipers, T.; Moonen, L.M.F.

    2000-01-01

    We explore the differences between developing a system using extreme programming techniques, and maintaining a legacy system. We investigate whether applying extreme programming techniques to legacy maintenance is useful and feasible.

  20. Extreme environment electronics

    CERN Document Server

    Cressler, John D

    2012-01-01

    Unfriendly to conventional electronic devices, circuits, and systems, extreme environments represent a serious challenge to designers and mission architects. The first truly comprehensive guide to this specialized field, Extreme Environment Electronics explains the essential aspects of designing and using devices, circuits, and electronic systems intended to operate in extreme environments, including across wide temperature ranges and in radiation-intense scenarios such as space. The Definitive Guide to Extreme Environment Electronics Featuring contributions by some of the world's foremost exp

  1. Upper Extremity Injuries in Gymnasts.

    Science.gov (United States)

    Wolf, Megan R; Avery, Daniel; Wolf, Jennifer Moriatis

    2017-02-01

    Gymnastics is a unique sport, which loads the wrist and arms as weight-bearing extremities. Because of the load demands on the wrist in particular, stress fractures, physeal injury, and overuse syndromes may be observed. This spectrum of injury has been termed "gymnast's wrist," and incorporates such disorders as wrist capsulitis, ligamentous tears, triangular fibrocartilage complex tears, chondromalacia of the carpus, stress fractures, distal radius physeal arrest, and grip lock injury.

  2. Deficiently Extremal Gorenstein Algebras

    Indian Academy of Sciences (India)

    Pavinder Singh

    2011-08-01

    The aim of this article is to study the homological properties of deficiently extremal Gorenstein algebras. We prove that if / is an odd deficiently extremal Gorenstein algebra with pure minimal free resolution, then the codimension of / must be odd. As an application, the structure of pure minimal free resolution of a nearly extremal Gorenstein algebra is obtained.

  3. Predicting Predictable about Natural Catastrophic Extremes

    Science.gov (United States)

    Kossobokov, Vladimir

    2015-04-01

    By definition, an extreme event is rare one in a series of kindred phenomena. Usually (e.g. in Geophysics), it implies investigating a small sample of case-histories with a help of delicate statistical methods and data of different quality, collected in various conditions. Many extreme events are clustered (far from independent) and follow fractal or some other "strange" distribution (far from uniform). Evidently, such an "unusual" situation complicates search and definition of reliable precursory behaviors to be used for forecast/prediction purposes. Making forecast/prediction claims reliable and quantitatively probabilistic in the frames of the most popular objectivists' viewpoint on probability requires a long series of "yes/no" forecast/prediction outcomes, which cannot be obtained without an extended rigorous test of the candidate method. The set of errors ("success/failure" scores and space-time measure of alarms) and other information obtained in such a control test supplies us with data necessary to judge the candidate's potential as a forecast/prediction tool and, eventually, to find its improvements. This is to be done first in comparison against random guessing, which results confidence (measured in terms of statistical significance). Note that an application of the forecast/prediction tools could be very different in cases of different natural hazards, costs and benefits that determine risks, and, therefore, requires determination of different optimal strategies minimizing reliable estimates of realistic levels of accepted losses. In their turn case specific costs and benefits may suggest a modification of the forecast/prediction tools for a more adequate "optimal" application. Fortunately, the situation is not hopeless due to the state-of-the-art understanding of the complexity and non-linear dynamics of the Earth as a Physical System and pattern recognition approaches applied to available geophysical evidences, specifically, when intending to predict

  4. Spatiotemporal variability of extreme temperature frequency and amplitude in China

    Science.gov (United States)

    Zhang, Yuanjie; Gao, Zhiqiu; Pan, Zaitao; Li, Dan; Huang, Xinhui

    2017-03-01

    Temperature extremes in China are examined based on daily maximum and minimum temperatures from station observations and multiple global climate models. The magnitude and frequency of extremes are expressed in terms of return values and periods, respectively, estimated by the fitted Generalized Extreme Value (GEV) distribution of annual extreme temperatures. The observations suggest that changes in temperature extremes considerably exceed changes in the respective climatological means during the past five decades, with greater amplitude of increases in cold extremes than in warm extremes. The frequency of warm (cold) extremes increases (decreases) over most areas, with an increasingly faster rate as the extremity level rises. Changes in warm extremes are more dependent on the varying shape of GEV distribution than the location shift, whereas changes in cold extremes are more closely associated with the location shift. The models simulate the overall pattern of temperature extremes during 1961-1981 reasonably well in China, but they show a smaller asymmetry between changes in warm and cold extremes primarily due to their underestimation of increases in cold extremes especially over southern China. Projections from a high emission scenario show the multi-model median change in warm and cold extremes by 2040 relative to 1971 will be 2.6 °C and 2.8 °C, respectively, with the strongest changes in cold extremes shifting southward. By 2040, warm extremes at the 1971 20-year return values would occur about every three years, while the 1971 cold extremes would occur once in > 500 years.

  5. Extreme value distributions

    CERN Document Server

    Ahsanullah, Mohammad

    2016-01-01

    The aim of the book is to give a through account of the basic theory of extreme value distributions. The book cover a wide range of materials available to date. The central ideas and results of extreme value distributions are presented. The book rwill be useful o applied statisticians as well statisticians interrested to work in the area of extreme value distributions.vmonograph presents the central ideas and results of extreme value distributions.The monograph gives self-contained of theory and applications of extreme value distributions.

  6. Quantification of Uncertainties in Projections of Hydro-meteorological Extremes

    Science.gov (United States)

    Meresa, Hadush; Romanowicz, Renata; Lawrence, Deborah

    2016-04-01

    The impact of climate change on hydrological extremes has been widely studied particularly after the publication of the IPCC AR4 report in 2007. The methodology applied to derive hydrological extremes under climate change adopted by most scientists consists of running a cascade of models, starting from assumed emission scenarios applied to a global circulation model (GCM) and ending at hydrological model simulations. Therefore, the projected hydro-meteorological extremes are highly uncertain due to uncertainties inherent in all the links of the modelling chain. In addition, due to the complexity of hydrologic models that use a large number of parameters to characterize hydrologic processes, many challenges arise with respect to quantification of uncertainty. This issue needs to be properly quantified to understand possible confidence ranges in extremes in the future. This paper aims to quantify the uncertainty in the hydrological projection of future extremes in streamflow and precipitation indices in mountainous and lowland catchments in Poland, using a multi-model approach based on climate projections obtained from the ENSMEBLE and EUROCORDEX projects, multiple realizations of catchment scale downscaled rainfalls, two hydrological models (HBV and GR4J) and a number of hydrological model parameters. The time-span of projections covers the 21st century. The potential sources of hydrological projection uncertainties are quantified through a Monte Carlo based simulation approach. We compare the weights based on different goodness-of-fit criteria in their ability to constrain the uncertainty of the extremes. The results of the comparison show a considerable dependence of uncertainty ranges on the type of extremes (low or high flows) and on the criterion used. The predicted distribution of future streamflows considering all sources of uncertainty (climate model, bias correction and hydrological model) is used to derive marginal distributions of uncertainty related to

  7. Investigation on rainfall extremes events trough a geoadditive model

    Science.gov (United States)

    Bocci, C.; Caporali, E.; Petrucci, A.; Rossi, G.

    2012-04-01

    Rainfall can be considered a very important variable, and rainfall extreme events analysis of great concern for the enormous impacts that they may have on everyday life particularly when related to intense rainfalls and floods, and hydraulic risk management. On the catchment area of Arno River in Tuscany, Central Italy, a geoadditive mixed model of rainfall extremes is developed. Most of the territory of Arno River has suffered in the past of many severe hydro-geological events, with high levels of risk due to the vulnerability of a unique artistic and cultural heritage. The area has a complex topography that greatly influences the precipitation regime. The dataset is composed by the time series of the annual maxima of daily rainfall recorded in about 400 rain gauges, spatially distributed over the catchment area of about 8.800 km2. The record period covers mainly the second half of 20th century. The rainfall observations are assumed to follow generalized extreme value distributions whose locations are spatially dependent and where the dependence is captured using a geoadditive model. In particular, since rainfall has a natural spatial domain and a significant spatial variability, a spatial hierarchical model for extremes is used. The spatial hierarchical models, in fact, take into account data from all locations, borrowing strength from neighbouring locations when they estimate parameters and are of great interest when small set of data is available, as in the case of rainfall extreme values. Together with rain gauges location variables further physiographic variables are investigated as explanation variables. The implemented geoadditive mixed model of spatially referenced time series of rainfall extreme values, is able to capture the spatial dynamics of the rainfall extreme phenomenon. Since the model shows evidence of a spatial trend in the rainfall extreme dynamic, the temporal dynamic and the time influence can be also taken into account. The implemented

  8. Infrared Multiphoton Dissociation Spectroscopy of a Gas-Phase Complex of Uranyl and 3-Oxa-Glutaramide: An Extreme Red-Shift of the [O=U=O]²⁺ Asymmetric Stretch

    Energy Technology Data Exchange (ETDEWEB)

    Gibson, John K.; Hu, Hanshi; Van Stipdonk, Michael J.; Berden, Giel; Oomens, Jos; Li, Jun

    2015-04-09

    The gas-phase complex UO₂(TMOGA)₂²⁺ (TMOGA = tetramethyl-3-oxa-glutaramide) prepared by electrospray ionization was characterized by infrared multiphoton dissociation (IRMPD) spectroscopy. The IRMPD spectrum from 700–1800 cm⁻¹ was interpreted using a computational study based on density functional theory. The predicted vibrational frequencies are in good agreement with the measured values, with an average deviation of only 8 cm⁻¹ (<1%) and a maximum deviation of 21 cm⁻¹ (<2%). The only IR peak assigned to the linear uranyl moiety was the asymmetric ν₃ mode, which appeared at 965 cm⁻¹ and was predicted by DFT as 953 cm⁻¹. This ν₃ frequency is red-shifted relative to bare uranyl, UO₂²⁺, by ca. 150 cm⁻¹ due to electron donation from the TMOGA ligands. Based on the degree of red-shifting, it is inferred that two TMOGA oxygen-donor ligands have a greater effective gas basicity than the four monodentate acetone ligands in UO₂(acetone)₄²⁺. The uranyl ν₃ frequency was also computed for uranyl coordinated by two TMGA ligands, in which the central Oether of TMOGA has been replaced by CH₂. The computed ν₃ for UO₂(TMGA)₂²⁺, 950 cm⁻¹, is essentially the same as that for UO₂(TMOGA)₂²⁺, suggesting that electron donation to uranyl from the Oether of TMOGA is minor. The computed ν₃ asymmetric stretching frequencies for the three actinyl complexes, UO₂(TMOGA)₂²⁺, NpO₂(TMOGA)₂²⁺ and PuO₂(TMOGA)₂²⁺, are comparable. This similarity is discussed in the context of the relationship between ν₃ and intrinsic actinide-oxygen bond energies in actinyl complexes.

  9. Extreme Velocity Wind Sensor

    Science.gov (United States)

    Perotti, Jose; Voska, Ned (Technical Monitor)

    2002-01-01

    This presentation provides an overview of the development of new hurricane wind sensor (Extreme Velocity Wind Sensor) for the Kennedy Space Center (KSC) which is designed to withstand winds of up to three hundred miles an hour. The proposed Extreme Velocity Wind Sensor contains no moveable components that would be exposed to extreme wind conditions. Topics covered include: need for new hurricane wind sensor, conceptual design, software applications, computational fluid dynamic simulations of design concept, preliminary performance tests, and project status.

  10. Detectors in Extreme Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Blaj, G. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Carini, G. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Carron, S. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Haller, G. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Hart, P. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Hasi, J. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Herrmann, S. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Kenney, C. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Segal, J. [SLAC National Accelerator Lab., Menlo Park, CA (United States); Tomada, A. [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-08-06

    Free Electron Lasers opened a new window on imaging the motion of atoms and molecules. At SLAC, FEL experiments are performed at LCLS using 120Hz pulses with 1012 - 1013 photons in 10 femtoseconds (billions of times brighter than the most powerful synchrotrons). This extreme detection environment raises unique challenges, from obvious to surprising. Radiation damage is a constant threat due to accidental exposure to insufficiently attenuated beam, focused beam and formation of ice crystals reflecting the beam onto the detector. Often high power optical lasers are also used (e.g., 25TW), increasing the risk of damage or impeding data acquisition through electromagnetic pulses (EMP). The sample can contaminate the detector surface or even produce shrapnel damage. Some experiments require ultra high vacuum (UHV) with strict design, surface contamination and cooling requirements - also for detectors. The setup is often changed between or during experiments with short turnaround times, risking mechanical and ESD damage, requiring work planning, training of operators and sometimes continuous participation of the LCLS Detector Group in the experiments. The detectors used most often at LCLS are CSPAD cameras for hard x-rays and pnCCDs for soft x-rays.

  11. How extreme is extreme hourly precipitation?

    Science.gov (United States)

    Papalexiou, Simon Michael; Dialynas, Yannis G.; Pappas, Christoforos

    2016-04-01

    The importance of accurate representation of precipitation at fine time scales (e.g., hourly), directly associated with flash flood events, is crucial in hydrological design and prediction. The upper part of a probability distribution, known as the distribution tail, determines the behavior of extreme events. In general, and loosely speaking, tails can be categorized in two families: the subexponential and the hyperexponential family, with the first generating more intense and more frequent extremes compared to the latter. In past studies, the focus has been mainly on daily precipitation, with the Gamma distribution being the most popular model. Here, we investigate the behaviour of tails of hourly precipitation by comparing the upper part of empirical distributions of thousands of records with three general types of tails corresponding to the Pareto, Lognormal, and Weibull distributions. Specifically, we use thousands of hourly rainfall records from all over the USA. The analysis indicates that heavier-tailed distributions describe better the observed hourly rainfall extremes in comparison to lighter tails. Traditional representations of the marginal distribution of hourly rainfall may significantly deviate from observed behaviours of extremes, with direct implications on hydroclimatic variables modelling and engineering design.

  12. On causality of extreme events

    CERN Document Server

    Zanin, Massimiliano

    2016-01-01

    Multiple metrics have been developed to detect causality relations between data describing the elements constituting complex systems, all of them considering their evolution through time. Here we propose a metric able to detect causality within static data sets, by analysing how extreme events in one element correspond to the appearance of extreme events in a second one. The metric is able to detect both linear and non-linear causalities; to analyse both cross-sectional and longitudinal data sets; and to discriminate between real causalities and correlations caused by confounding factors. We validate the metric through synthetic data, dynamical and chaotic systems, and data representing the human brain activity in a cognitive task.

  13. On causality of extreme events

    Directory of Open Access Journals (Sweden)

    Massimiliano Zanin

    2016-06-01

    Full Text Available Multiple metrics have been developed to detect causality relations between data describing the elements constituting complex systems, all of them considering their evolution through time. Here we propose a metric able to detect causality within static data sets, by analysing how extreme events in one element correspond to the appearance of extreme events in a second one. The metric is able to detect non-linear causalities; to analyse both cross-sectional and longitudinal data sets; and to discriminate between real causalities and correlations caused by confounding factors. We validate the metric through synthetic data, dynamical and chaotic systems, and data representing the human brain activity in a cognitive task. We further show how the proposed metric is able to outperform classical causality metrics, provided non-linear relationships are present and large enough data sets are available.

  14. On causality of extreme events

    Science.gov (United States)

    2016-01-01

    Multiple metrics have been developed to detect causality relations between data describing the elements constituting complex systems, all of them considering their evolution through time. Here we propose a metric able to detect causality within static data sets, by analysing how extreme events in one element correspond to the appearance of extreme events in a second one. The metric is able to detect non-linear causalities; to analyse both cross-sectional and longitudinal data sets; and to discriminate between real causalities and correlations caused by confounding factors. We validate the metric through synthetic data, dynamical and chaotic systems, and data representing the human brain activity in a cognitive task. We further show how the proposed metric is able to outperform classical causality metrics, provided non-linear relationships are present and large enough data sets are available. PMID:27330866

  15. Extremism from the perspective of a system approach

    Directory of Open Access Journals (Sweden)

    Zinchenko, Yury P.

    2014-03-01

    Full Text Available Extremism is seen as a complex, multilevel, and multicomponent phenomenon. The problems of modern science in understanding extremism are revealed. The following bases of extremism as a system phenomenon are singled out: social factors, latent extremism, and extremist acts. It is demonstrated that a system approach makes it possible to shape a notion of a subject as a system, to identify patterns of the manifestations of the given phenomenon, and to translate them into concrete practices.

  16. [Injury mechanisms in extreme violence settings].

    Science.gov (United States)

    Arcaute-Velazquez, Fernando Federico; García-Núñez, Luis Manuel; Noyola-Vilallobos, Héctor Faustino; Espinoza-Mercado, Fernando; Rodríguez-Vega, Carlos Eynar

    2016-01-01

    Extreme violence events are consequence of current world-wide economic, political and social conditions. Injury patterns found among victims of extreme violence events are very complex, obeying several high-energy injury mechanisms. In this article, we present the basic concepts of trauma kinematics that regulate the clinical approach to victims of extreme violence events, in the hope that clinicians increase their theoretical armamentarium, and reflecting on obtaining better outcomes. Copyright © 2016. Published by Masson Doyma México S.A.

  17. Classifying Returns as Extreme

    DEFF Research Database (Denmark)

    Christiansen, Charlotte

    2014-01-01

    I consider extreme returns for the stock and bond markets of 14 EU countries using two classification schemes: One, the univariate classification scheme from the previous literature that classifies extreme returns for each market separately, and two, a novel multivariate classification scheme tha...

  18. Upper-extremity deep venous thrombosis: a review.

    Science.gov (United States)

    Mai, Cuc; Hunt, Daniel

    2011-05-01

    Upper-extremity deep venous thrombosis is less common than lower-extremity deep venous thrombosis. However, upper-extremity deep venous thrombosis is associated with similar adverse consequences and is becoming more common in patients with complex medical conditions requiring central venous catheters or wires. Although guidelines suggest that this disorder be managed using approaches similar to those for lower-extremity deep venous thrombosis, studies are refining the prognosis and management of upper-extremity deep venous thrombosis. Physicians should be familiar with the diagnostic and treatment considerations for this disease. This review will differentiate between primary and secondary upper-extremity deep venous thromboses; assess the risk factors and clinical sequelae associated with upper-extremity deep venous thrombosis, comparing these with lower-extremity deep venous thrombosis; and describe an approach to treatment and prevention of secondary upper-extremity deep venous thrombosis based on clinical evidence.

  19. Non-Gaussian statistics and extreme waves in a nonlinear optical cavity.

    Science.gov (United States)

    Montina, A; Bortolozzo, U; Residori, S; Arecchi, F T

    2009-10-23

    A unidirectional optical oscillator is built by using a liquid crystal light valve that couples a pump beam with the modes of a nearly spherical cavity. For sufficiently high pump intensity, the cavity field presents complex spatiotemporal dynamics, accompanied by the emission of extreme waves and large deviations from the Gaussian statistics. We identify a mechanism of spatial symmetry breaking, due to a hypercycle-type amplification through the nonlocal coupling of the cavity field.

  20. Complex Convexity of Orlicz Modular Sequence Spaces

    Directory of Open Access Journals (Sweden)

    Lili Chen

    2016-01-01

    Full Text Available The concepts of complex extreme points, complex strongly extreme points, complex strict convexity, and complex midpoint locally uniform convexity in general modular spaces are introduced. Then we prove that, for any Orlicz modular sequence space lΦ,ρ, lΦ,ρ is complex midpoint locally uniformly convex. As a corollary, lΦ,ρ is also complex strictly convex.

  1. Reliability of the mangled extremity severity score in combat-related upper and lower extremity injuries

    OpenAIRE

    Tolga Ege; Aytekin Unlu; Huseyin Tas; Dogan Bek; Selim Turkan; Aytac Cetinkaya

    2015-01-01

    Background: Decision of limb salvage or amputation is generally aided with several trauma scoring systems such as the mangled extremity severity score (MESS). However, the reliability of the injury scores in the settling of open fractures due to explosives and missiles is challenging. Mortality and morbidity of the extremity trauma due to firearms are generally associated with time delay in revascularization, injury mechanism, anatomy of the injured site, associated injuries, age and the envi...

  2. Extreme wind turbine response during operation

    DEFF Research Database (Denmark)

    Sørensen, John Dalsgaard; Nielsen, S.R.K.

    2007-01-01

    Estimation of extreme response values is very important for structural design of wind turbines. Due to the influence of control system and nonlinear structural behavior the extreme response is usually assessed based on simulation of turbulence time series. In this paper the problem of statistical...... provides a tool to obtain consistent estimates incl. the statistical uncertainty. An illustrative example indicates that the statistical uncertainty is important compared to the coefficient of variation of the extreme response when the number of 10 minutes simulations at each mean wind speed is limited...

  3. Climate extremes and the carbon cycle (Invited)

    Science.gov (United States)

    Reichstein, M.; Bahn, M.; Ciais, P.; Mahecha, M. D.; Seneviratne, S. I.; Zscheischler, J.

    2013-12-01

    The terrestrial biosphere is a key component of the global carbon cycle and its carbon balance is strongly influenced by climate. Ongoing environmental changes are thought to increase global terrestrial carbon uptake. But evidence is mounting that rare climate extremes can lead to a decrease in ecosystem carbon stocks and therefore have the potential to negate the expected increase in terrestrial carbon uptake. Here we explore the mechanisms and impacts of climate extremes on the terrestrial carbon cycle, and propose a pathway to improve our understanding of present and future impacts of climate extremes on the terrestrial carbon budget. In addition to direct impact on the carbon fluxes of photosynthesis and respiration via extreme temperature and (or) drought, effects of extreme events may also lead to lagged responses, such as wildfires triggered by heat waves and droughts, or pest and pathogen outbreaks following wind-throw caused by heavy storms, reduced plant health due to drought stress or due to less frequent cold extremes in presently cold regions. One extreme event can potentially override accumulated previous carbon sinks, as shown by the Western European 2003 heat wave.. Extreme events have the potential to affect the terrestrial ecosystem carbon balance through a single factor, or as a combination of factors. Climate extremes can cause carbon losses from accumulated stocks, as well as long-lasting impacts on (e.g. lagged effects) on plant growth and mortality, extending beyond the duration of the extreme event itself. The sensitivity of terrestrial ecosystems and their carbon balance to climate change and extreme events varies according to the type of extreme, the climatic region, the land cover, and the land management. Extreme event impacts are very relevant in forests due to the importance of lagged and memory effects on tree growth and mortality, the longevity of tree species, the large forest carbon stocks and their vulnerability, as well as the

  4. Moving in extreme environments

    DEFF Research Database (Denmark)

    Lucas, Samuel J E; Helge, Jørn W; Schütz, Uwe H W;

    2016-01-01

    This review addresses human capacity for movement in the context of extreme loading and with it the combined effects of metabolic, biomechanical and gravitational stress on the human body. This topic encompasses extreme duration, as occurs in ultra-endurance competitions (e.g. adventure racing...... and transcontinental races) and expeditions (e.g. polar crossings), to the more gravitationally limited load carriage (e.g. in the military context). Juxtaposed to these circumstances is the extreme metabolic and mechanical unloading associated with space travel, prolonged bedrest and sedentary lifestyle, which may...

  5. Extremal surface barriers

    Energy Technology Data Exchange (ETDEWEB)

    Engelhardt, Netta; Wall, Aron C. [Department of Physics, University of California,Santa Barbara, CA 93106 (United States)

    2014-03-13

    We present a generic condition for Lorentzian manifolds to have a barrier that limits the reach of boundary-anchored extremal surfaces of arbitrary dimension. We show that any surface with nonpositive extrinsic curvature is a barrier, in the sense that extremal surfaces cannot be continuously deformed past it. Furthermore, the outermost barrier surface has nonnegative extrinsic curvature. Under certain conditions, we show that the existence of trapped surfaces implies a barrier, and conversely. In the context of AdS/CFT, these barriers imply that it is impossible to reconstruct the entire bulk using extremal surfaces. We comment on the implications for the firewall controversy.

  6. Analysis of extreme events

    CSIR Research Space (South Africa)

    Khuluse, S

    2009-04-01

    Full Text Available ) determination of the distribution of the damage and (iii) preparation of products that enable prediction of future risk events. The methodology provided by extreme value theory can also be a powerful tool in risk analysis...

  7. Extreme environments and exobiology.

    Science.gov (United States)

    Friedmann, E I

    1993-01-01

    Ecological research on extreme environments can be applied to exobiological problems such as the question of life on Mars. If life forms (fossil or extant) are found on Mars, their study will help to solve fundamental questions about the nature of life on Earth. Extreme environments that are beyond the range of adaptability of their inhabitants are defined as "absolute extreme". Such environments can serve as terrestrial models for the last stages of life in the history of Mars, when the surface cooled down and atmosphere and water disappeared. The cryptoendolithic microbial community in porous rocks of the Ross Desert in Antarctica and the microbial mats at the bottom of frozen Antarctic lakes are such examples. The microbial communities of Siberian permafrost show that, in frozen but stable communities, long-term survival is possible. In the context of terraforming Mars, selected microorganisms isolated from absolute extreme environments are considered for use in creation of a biological carbon cycle.

  8. Venous Ultrasound (Extremities)

    Science.gov (United States)

    ... News Physician Resources Professions Site Index A-Z Ultrasound - Venous (Extremities) Venous ultrasound uses sound waves to ... limitations of Venous Ultrasound Imaging? What is Venous Ultrasound Imaging? Ultrasound is safe and painless, and produces ...

  9. Statistics of extremes

    CERN Document Server

    Gumbel, E J

    2012-01-01

    This classic text covers order statistics and their exceedances; exact distribution of extremes; the 1st asymptotic distribution; uses of the 1st, 2nd, and 3rd asymptotes; more. 1958 edition. Includes 44 tables and 97 graphs.

  10. Extremal limits and Ba\\~nados-Silk-West effect

    CERN Document Server

    Pradhan, Parthapratim

    2016-01-01

    A fascinating property of extremal Kerr black hole (BH) is that it could be act as a particle accelerator with infinite high center-of-mass (CM) energy \\cite{bsw}. In this note, we would like to discuss about such fascinating result and to point out that this infinite energy at the event horizon comes solely due \\emph{to the singular nature of the extremal limit}. We also show that a non-extremal Kerr BH can \\emph{not} transform into extremal Kerr BH by the Ba\\~{n}ados-Silk-West mechanism. Moreover, we discuss about three possible geometries (near extremal, purely extremal and near horizon of extremal Kerr) of this mechanism. We further prove that near extremal geometry and near horizon geometry, precisely extremal geometry of extremal Kerr BHs are qualitatively different. Near extremal geometry and near horizon geometry gives the CM energy is finite, whereas precisely extremal geometry gives the diverging energy. Thus, we can argue that extremal Kerr BH and non-extremal Kerr BH are quite distinct objects. Fi...

  11. Extreme Programming: Maestro Style

    Science.gov (United States)

    Norris, Jeffrey; Fox, Jason; Rabe, Kenneth; Shu, I-Hsiang; Powell, Mark

    2009-01-01

    "Extreme Programming: Maestro Style" is the name of a computer programming methodology that has evolved as a custom version of a methodology, called extreme programming that has been practiced in the software industry since the late 1990s. The name of this version reflects its origin in the work of the Maestro team at NASA's Jet Propulsion Laboratory that develops software for Mars exploration missions. Extreme programming is oriented toward agile development of software resting on values of simplicity, communication, testing, and aggressiveness. Extreme programming involves use of methods of rapidly building and disseminating institutional knowledge among members of a computer-programming team to give all the members a shared view that matches the view of the customers for whom the software system is to be developed. Extreme programming includes frequent planning by programmers in collaboration with customers, continually examining and rewriting code in striving for the simplest workable software designs, a system metaphor (basically, an abstraction of the system that provides easy-to-remember software-naming conventions and insight into the architecture of the system), programmers working in pairs, adherence to a set of coding standards, collaboration of customers and programmers, frequent verbal communication, frequent releases of software in small increments of development, repeated testing of the developmental software by both programmers and customers, and continuous interaction between the team and the customers. The environment in which the Maestro team works requires the team to quickly adapt to changing needs of its customers. In addition, the team cannot afford to accept unnecessary development risk. Extreme programming enables the Maestro team to remain agile and provide high-quality software and service to its customers. However, several factors in the Maestro environment have made it necessary to modify some of the conventional extreme

  12. To the limit of extreme malnutrition

    DEFF Research Database (Denmark)

    Frølich, Jacob; Buskbjerg, Camilla Viola; Støving, Rene K

    2016-01-01

    Extreme malnutrition with body mass index (BMI) as low as 10 kg/m(2) is not uncommon in anorexia nervosa, with survival enabled through complex metabolic adaptations. In contrast, outcomes from hunger strikes and famines are usually fatal after weight loss to about 40% below expected body weight,...

  13. Calabi Energies of Extremal Toric Surfaces

    CERN Document Server

    LeBrun, Claude

    2011-01-01

    We derive a formula for the L^2 norm of the scalar curvature of any extremal Kaehler metric on a compact complex toric surface, stated purely in terms of the geometry of the corresponding moment polygon. We then describe some applications of this formula to the construction of 4-manifolds with vanishing Bach tensor.

  14. Statistics of Extremes

    KAUST Repository

    Davison, Anthony C.

    2015-04-10

    Statistics of extremes concerns inference for rare events. Often the events have never yet been observed, and their probabilities must therefore be estimated by extrapolation of tail models fitted to available data. Because data concerning the event of interest may be very limited, efficient methods of inference play an important role. This article reviews this domain, emphasizing current research topics. We first sketch the classical theory of extremes for maxima and threshold exceedances of stationary series. We then review multivariate theory, distinguishing asymptotic independence and dependence models, followed by a description of models for spatial and spatiotemporal extreme events. Finally, we discuss inference and describe two applications. Animations illustrate some of the main ideas. © 2015 by Annual Reviews. All rights reserved.

  15. Extremely deformable structures

    CERN Document Server

    2015-01-01

    Recently, a new research stimulus has derived from the observation that soft structures, such as biological systems, but also rubber and gel, may work in a post critical regime, where elastic elements are subject to extreme deformations, though still exhibiting excellent mechanical performances. This is the realm of ‘extreme mechanics’, to which this book is addressed. The possibility of exploiting highly deformable structures opens new and unexpected technological possibilities. In particular, the challenge is the design of deformable and bi-stable mechanisms which can reach superior mechanical performances and can have a strong impact on several high-tech applications, including stretchable electronics, nanotube serpentines, deployable structures for aerospace engineering, cable deployment in the ocean, but also sensors and flexible actuators and vibration absorbers. Readers are introduced to a variety of interrelated topics involving the mechanics of extremely deformable structures, with emphasis on ...

  16. Precursors of extreme increments

    CERN Document Server

    Hallerberg, S; Holstein, D; Kantz, H; Hallerberg, Sarah; Altmann, Eduardo G.; Holstein, Detlef; Kantz, Holger

    2006-01-01

    We investigate precursors and predictability of extreme events in time series, which consist in large increments within successive time steps. In order to understand the predictability of this class of extreme events, we study analytically the prediction of extreme increments in AR(1)-processes. The resulting strategies are then applied to predict sudden increases in wind speed recordings. In both cases we evaluate the success of predictions via creating receiver operator characteristics (ROC-plots). Surprisingly, we obtain better ROC-plots for completely uncorrelated Gaussian random numbers than for AR(1)-correlated data. Furthermore, we observe an increase of predictability with increasing event size. Both effects can be understood by using the likelihood ratio as a summary index for smooth ROC-curves.

  17. Weather and Climate Extremes.

    Science.gov (United States)

    1997-09-01

    Antarctica’s highest (New Zealand Antarctic Society, 1974). This extreme exceeded the record of 58°F (14.4°C) that occurred on 20 October 1956 at Esperanza ... Esperanza (also known as Bahia Esperanza , Hope Bay) was in operation from 1945 through the early 1960s. Meteorological/Climatological Factors: This extreme...cm) Location: Grand Ilet, La R’eunion Island [21°00’S, 55°30’E] Date: 26 January 1980 WORLD’S GREATEST 24-HOUR RAINFALL 72 in (182.5 cm

  18. Adventure and Extreme Sports.

    Science.gov (United States)

    Gomez, Andrew Thomas; Rao, Ashwin

    2016-03-01

    Adventure and extreme sports often involve unpredictable and inhospitable environments, high velocities, and stunts. These activities vary widely and include sports like BASE jumping, snowboarding, kayaking, and surfing. Increasing interest and participation in adventure and extreme sports warrants understanding by clinicians to facilitate prevention, identification, and treatment of injuries unique to each sport. This article covers alpine skiing and snowboarding, skateboarding, surfing, bungee jumping, BASE jumping, and whitewater sports with emphasis on epidemiology, demographics, general injury mechanisms, specific injuries, chronic injuries, fatality data, and prevention. Overall, most injuries are related to overuse, trauma, and environmental or microbial exposure.

  19. Extremal graph theory

    CERN Document Server

    Bollobas, Bela

    2004-01-01

    The ever-expanding field of extremal graph theory encompasses a diverse array of problem-solving methods, including applications to economics, computer science, and optimization theory. This volume, based on a series of lectures delivered to graduate students at the University of Cambridge, presents a concise yet comprehensive treatment of extremal graph theory.Unlike most graph theory treatises, this text features complete proofs for almost all of its results. Further insights into theory are provided by the numerous exercises of varying degrees of difficulty that accompany each chapter. A

  20. Extremes in random fields a theory and its applications

    CERN Document Server

    Yakir, Benjamin

    2013-01-01

    Presents a useful new technique for analyzing the extreme-value behaviour of random fields Modern science typically involves the analysis of increasingly complex data. The extreme values that emerge in the statistical analysis of complex data are often of particular interest. This book focuses on the analytical approximations of the statistical significance of extreme values. Several relatively complex applications of the technique to problems that emerge in practical situations are presented.  All the examples are difficult to analyze using classical methods, and as a result, the author pr

  1. Extremity perfusion for sarcoma

    NARCIS (Netherlands)

    Hoekstra, Harald Joan

    2008-01-01

    For more than 50 years, the technique of extremity perfusion has been explored in the limb salvage treatment of local, recurrent, and multifocal sarcomas. The "discovery" of tumor necrosis factor-or. in combination with melphalan was a real breakthrough in the treatment of primarily irresectable ext

  2. Hydrological extremes and security

    Science.gov (United States)

    Kundzewicz, Z. W.; Matczak, P.

    2015-04-01

    Economic losses caused by hydrological extremes - floods and droughts - have been on the rise. Hydrological extremes jeopardize human security and impact on societal livelihood and welfare. Security can be generally understood as freedom from threat and the ability of societies to maintain their independent identity and their functional integrity against forces of change. Several dimensions of security are reviewed in the context of hydrological extremes. The traditional interpretation of security, focused on the state military capabilities, has been replaced by a wider understanding, including economic, societal and environmental aspects that get increasing attention. Floods and droughts pose a burden and serious challenges to the state that is responsible for sustaining economic development, and societal and environmental security. The latter can be regarded as the maintenance of ecosystem services, on which a society depends. An important part of it is water security, which can be defined as the availability of an adequate quantity and quality of water for health, livelihoods, ecosystems and production, coupled with an acceptable level of water-related risks to people, environments and economies. Security concerns arise because, over large areas, hydrological extremes - floods and droughts - are becoming more frequent and more severe. In terms of dealing with water-related risks, climate change can increase uncertainties, which makes the state's task to deliver security more difficult and more expensive. However, changes in population size and development, and level of protection, drive exposure to hydrological hazards.

  3. Acute lower extremity ischaemia

    African Journals Online (AJOL)

    tend to impact at arterial bifurcations, the commonest site being the ... Other ominous signs of advanced ischaemia include bluish ... Recommended standards for lower extremity ischaemia*. Doppler signals ... of the embolectomy procedure. An ... in a cath-lab or angio-suite under local ... We serially measure the aPTT and.

  4. Extremity perfusion for sarcoma

    NARCIS (Netherlands)

    Hoekstra, Harald Joan

    2008-01-01

    For more than 50 years, the technique of extremity perfusion has been explored in the limb salvage treatment of local, recurrent, and multifocal sarcomas. The "discovery" of tumor necrosis factor-or. in combination with melphalan was a real breakthrough in the treatment of primarily irresectable

  5. Statistics of Local Extremes

    DEFF Research Database (Denmark)

    Larsen, Gunner Chr.; Bierbooms, W.; Hansen, Kurt Schaldemose

    2003-01-01

    . A theoretical expression for the probability density function associated with local extremes of a stochasticprocess is presented. The expression is basically based on the lower four statistical moments and a bandwidth parameter. The theoretical expression is subsequently verified by comparison with simulated...

  6. Moving in extreme environments

    DEFF Research Database (Denmark)

    Lucas, Samuel J E; Helge, Jørn W; Schütz, Uwe H W

    2016-01-01

    and transcontinental races) and expeditions (e.g. polar crossings), to the more gravitationally limited load carriage (e.g. in the military context). Juxtaposed to these circumstances is the extreme metabolic and mechanical unloading associated with space travel, prolonged bedrest and sedentary lifestyle, which may...

  7. Extreme Weather Events and Climate Change Attribution

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Katherine [National Academy of Sciences, Washington, DC (United States)

    2016-03-31

    A report from the National Academies of Sciences, Engineering, and Medicine concludes it is now possible to estimate the influence of climate change on some types of extreme events. The science of extreme event attribution has advanced rapidly in recent years, giving new insight to the ways that human-caused climate change can influence the magnitude or frequency of some extreme weather events. This report examines the current state of science of extreme weather attribution, and identifies ways to move the science forward to improve attribution capabilities. Confidence is strongest in attributing types of extreme events that are influenced by climate change through a well-understood physical mechanism, such as, the more frequent heat waves that are closely connected to human-caused global temperature increases, the report finds. Confidence is lower for other types of events, such as hurricanes, whose relationship to climate change is more complex and less understood at present. For any extreme event, the results of attribution studies hinge on how questions about the event's causes are posed, and on the data, modeling approaches, and statistical tools chosen for the analysis.

  8. Complex Regional Pain Syndrome

    Science.gov (United States)

    Complex regional pain syndrome (CRPS) is a chronic pain condition. It causes intense pain, usually in the arms, hands, legs, or feet. ... in skin temperature, color, or texture Intense burning pain Extreme skin sensitivity Swelling and stiffness in affected ...

  9. Extreme wave and wind response predictions

    DEFF Research Database (Denmark)

    Jensen, Jørgen Juncher; Olsen, Anders S.; Mansour, Alaa E.

    2011-01-01

    The aim of the paper is to advocate effective stochastic procedures, based on the First Order Reliability Method (FORM) and Monte Carlo simulations (MCS), for extreme value predictions related to wave and wind-induced loads.Due to the efficient optimization procedures implemented in standard FORM...

  10. Committee VI.1. Extreme Hull Girder Loading

    DEFF Research Database (Denmark)

    Jensen, Jørgen Juncher

    2000-01-01

    Committee Mandate. Evaluate and develop direct calculation procedures for extreme wawe loads on ship hull girders. Due consideration shall be given to stochastic and non-linear effects. The procedures shall be assessed by comparison with in-service experiences, model tests and more refined...

  11. 依达拉奉对深低温冻存大鼠断肢再植后缺血再灌注损伤骨骼肌细胞膜及线粒体的保护效应%Protective influence of edaravone on cellular membrane and mitochondria of replanted rat extremities following ischemia/reperfusion injury due to cryopreservation and rewarming

    Institute of Scientific and Technical Information of China (English)

    段永壮; 钟世镇; 王增涛; 徐达传; 丁自海; 付庆林; 郝丽文; 何波

    2007-01-01

    肌缺血再灌注损伤,对骨骼肌细胞膜及线粒体有保护作用.其作用可能与依达拉奉直接抑制羟自由基、提高骨骼肌超氧化物歧化酶活性、减少丙二醛的产生,使细胞进行正常的氧化磷酸化有关.%BACKGROUND: A lot of important organs are worthless for clinical application because they are hard to store for a long time. In addition, tissues or organs which are dealt with cryopreservation also attack ischemia/reperfusion injury with the recovery of blood flow; especially, skeletal muscle is the most involved tissue.OBJECTIVE: To observe the protective influence of edaravone on cellular membrane and mitochondria of replanted rat extremities following ischemia/reperfusion injury due to cryopreservation and rewarming.DESIGN: Randomized contrast animal study.SETTING: Basic Medical College of Southern Medical University; Department of Hand and Foot Surgery, Shandong Provincial Hospital.MATERIALS: The experiment was carried out in the Cryopreservation Laboratory, Shandong Provincial Hospital from April to November 2006. A total of 36 healthy adult male Wistar rats were provided by Experimental Animal Center of Medical College of Shandong University. All rats were randomly divided into control group, cryopreservation group and edaravone group with 12 in each group.METHODS: Femoral artery and vein of rats in control group were exposured, but extremities were not blocked. Rats in other two groups were used to establish ischemia/reperfusion injury models of replanted extremities. Before cryopreservation, their right hindlimbs were cut off and maintained in liquid nitrogen container for 1 month. After the operation mentioned above, the broken limbs were rewarmed, perfused with routine eluant and replanted. Four hours later, blood supply of extremities was recirculated and the samples were selected. Eluant in edaravone group contained 0.5 mg/kg edaravone. Samples of skeletal muscle were selected at the same time point to

  12. Reliability of the mangled extremity severity score in combat-related upper and lower extremity injuries

    Directory of Open Access Journals (Sweden)

    Tolga Ege

    2015-01-01

    Full Text Available Background: Decision of limb salvage or amputation is generally aided with several trauma scoring systems such as the mangled extremity severity score (MESS. However, the reliability of the injury scores in the settling of open fractures due to explosives and missiles is challenging. Mortality and morbidity of the extremity trauma due to firearms are generally associated with time delay in revascularization, injury mechanism, anatomy of the injured site, associated injuries, age and the environmental circumstance. The purpose of the retrospective study was to evaluate the extent of extremity injuries due to ballistic missiles and to detect the reliability of mangled extremity severity score (MESS in both upper and lower extremities. Materials and Methods: Between 2004 and 2014, 139 Gustillo Anderson Type III open fractures of both the upper and lower extremities were enrolled in the study. Data for patient age, fire arm type, transporting time from the field to the hospital (and the method, injury severity scores, MESS scores, fracture types, amputation levels, bone fixation methods and postoperative infections and complications retrieved from the two level-2 trauma center's data base. Sensitivity, specificity, positive and negative predictive values of the MESS were calculated to detect the ability in deciding amputation in the mangled limb. Results: Amputation was performed in 39 extremities and limb salvage attempted in 100 extremities. The mean followup time was 14.6 months (range 6–32 months. In the amputated group, the mean MESS scores for upper and lower extremity were 8.8 (range 6–11 and 9.24 (range 6–11, respectively. In the limb salvage group, the mean MESS scores for upper and lower extremities were 5.29 (range 4–7 and 5.19 (range 3–8, respectively. Sensitivity of MESS in upper and lower extremities were calculated as 80% and 79.4% and positive predictive values detected as 55.55% and 83.3%, respectively. Specificity of MESS

  13. Extremal surfaces in de Sitter spacetime

    Science.gov (United States)

    Narayan, K.

    2015-06-01

    We study extremal surfaces in de Sitter space in the Poincare slicing in the upper patch, anchored on spatial subregions at the future boundary I+, restricted to constant boundary Euclidean time slices (focusing on strip subregions). We find real extremal surfaces of minimal area as the boundaries of past light-cone wedges of the subregions in question: these are null surfaces with vanishing area. We also find complex extremal surfaces as complex extrema of the area functional, and the area is not always real valued. In dS4 the area is real. The area has structural resemblance with entanglement entropy in a dual conformal field theory. There are parallels with analytic continuation from the Ryu-Takayanagi expressions for holographic entanglement entropy in anti-de Sitter. We also discuss extremal surfaces in the de Sitter (dS) black brane and the de Sitter "bluewall" studied previously. The dS4 black brane complex surfaces exhibit a real finite cutoff-independent extensive piece. In the bluewall geometry, there are real surfaces that go from one asymptotic universe to the other through the Cauchy horizons.

  14. Weather extremes could affect agriculture

    Science.gov (United States)

    Balcerak, Ernie

    2012-05-01

    As Earth's climate warms, agricultural producers will need to adapt. Changes, especially increases in extreme events, are already having an impact on food production, according to speakers at a 1 May session on agriculture and food security at the AGU Science Policy Conference. Christopher Field, director of the Department of Global Ecology at the Carnegie Institution for Science of Washington, D. C., pointed out the complex factors that come into play in understanding food security, including spatially varying controls and stresses, incomplete models, and the potential for threshold responses. Factors that are likely to cause problems include increasing population; increasing preference for meat, which needs more land and energy inputs to produce; climate change; and increasing use of agricultural lands for biomass energy.

  15. Extreme Geomagnetic Storms - 1868 - 2010

    Science.gov (United States)

    Vennerstrom, S.; Lefevre, L.; Dumbović, M.; Crosby, N.; Malandraki, O.; Patsou, I.; Clette, F.; Veronig, A.; Vršnak, B.; Leer, K.; Moretto, T.

    2016-05-01

    We present the first large statistical study of extreme geomagnetic storms based on historical data from the time period 1868 - 2010. This article is the first of two companion papers. Here we describe how the storms were selected and focus on their near-Earth characteristics. The second article presents our investigation of the corresponding solar events and their characteristics. The storms were selected based on their intensity in the aa index, which constitutes the longest existing continuous series of geomagnetic activity. They are analyzed statistically in the context of more well-known geomagnetic indices, such as the Kp and Dcx/Dst index. This reveals that neither Kp nor Dcx/Dst provide a comprehensive geomagnetic measure of the extreme storms. We rank the storms by including long series of single magnetic observatory data. The top storms on the rank list are the New York Railroad storm occurring in May 1921 and the Quebec storm from March 1989. We identify key characteristics of the storms by combining several different available data sources, lists of storm sudden commencements (SSCs) signifying occurrence of interplanetary shocks, solar wind in-situ measurements, neutron monitor data, and associated identifications of Forbush decreases as well as satellite measurements of energetic proton fluxes in the near-Earth space environment. From this we find, among other results, that the extreme storms are very strongly correlated with the occurrence of interplanetary shocks (91 - 100 %), Forbush decreases (100 %), and energetic solar proton events (70 %). A quantitative comparison of these associations relative to less intense storms is also presented. Most notably, we find that most often the extreme storms are characterized by a complexity that is associated with multiple, often interacting, solar wind disturbances and that they frequently occur when the geomagnetic activity is already elevated. We also investigate the semiannual variation in storm occurrence

  16. Non-extremal branes

    Directory of Open Access Journals (Sweden)

    Pablo Bueno

    2015-04-01

    Full Text Available We prove that for arbitrary black brane solutions of generic Supergravities there is an adapted system of variables in which the equations of motion are exactly invariant under electric–magnetic duality, i.e. the interchange of a given extended object by its electromagnetic dual. We obtain thus a procedure to automatically construct the electromagnetic dual of a given brane without needing to solve any further equation. We apply this procedure to construct the non-extremal (p,q-string of Type-IIB String Theory (new in the literature, explicitly showing how the dual (p,q-five-brane automatically arises in this construction. In addition, we prove that the system of variables used is suitable for a generic characterization of every double-extremal Supergravity brane solution, which we perform in full generality.

  17. Tibetans at extreme altitude.

    Science.gov (United States)

    Wu, Tianyi; Li, Shupin; Ward, Michal P

    2005-01-01

    Between 1960 and 2003, 13 Chinese expeditions successfully reached the summit of Chomolungma (Mt Everest or Sagarmatha). Forty-five of the 80 summiteers were Tibetan highlanders. During these and other high-altitude expeditions in Tibet, a series of medical and physiological investigations were carried out on the Tibetan mountaineers. The results suggest that these individuals are better adapted to high altitude and that, at altitude, they have a greater physical capacity than Han (ethnic Chinese) lowland newcomers. They have higher maximal oxygen uptake, greater ventilation, more brisk hypoxic ventilatory responses, larger lung volumes, greater diffusing capacities, and a better quality of sleep. Tibetans also have a lower incidence of acute mountain sickness and less body weight loss. These differences appear to represent genetic adaptations and are obviously significant for humans at extreme altitude. This paper reviews what is known about the physiologic responses of Tibetans at extreme altitudes.

  18. Extremal periodic wave profiles

    Directory of Open Access Journals (Sweden)

    E. van Groesen

    2007-01-01

    Full Text Available As a contribution to deterministic investigations into extreme fluid surface waves, in this paper wave profiles of prescribed period that have maximal crest height will be investigated. As constraints the values of the momentum and energy integrals are used in a simplified description with the KdV model. The result is that at the boundary of the feasible region in the momentum-energy plane, the only possible profiles are the well known cnoidal wave profiles. Inside the feasible region the extremal profiles of maximal crest height are "cornered" cnoidal profiles: cnoidal profiles of larger period, cut-off and periodically continued with the prescribed period so that at the maximal crest height a corner results.

  19. Extreme Photonics & Applications

    CERN Document Server

    Hall, Trevor J; Paredes, Sofia A

    2010-01-01

    "Extreme Photonics & Applications" arises from the 2008 NATO Advanced Study Institute in Laser Control & Monitoring in New Materials, Biomedicine, Environment, Security and Defense. Leading experts in the manipulation of light offered by recent advances in laser physics and nanoscience were invited to give lectures in their fields of expertise and participate in discussions on current research, applications and new directions. The sum of their contributions to this book is a primer for the state of scientific knowledge and the issues within the subject of photonics taken to the extreme frontiers: molding light at the ultra-finest scales, which represents the beginning of the end to limitations in optical science for the benefit of 21st Century technological societies. Laser light is an exquisite tool for physical and chemical research. Physicists have recently developed pulsed lasers with such short durations that one laser shot takes the time of one molecular vibration or one electron rotation in an ...

  20. Extremal Hairy Black Holes

    CERN Document Server

    Gonzalez, P A; Saavedra, Joel; Vasquez, Yerko

    2014-01-01

    We consider a gravitating system consisting of a scalar field minimally coupled to gravity with a self-interacting potential and an U(1) electromagnetic field. Solving the coupled Einstein-Maxwell-scalar system we find exact hairy charged black hole solutions with the scalar field regular everywhere. We go to the zero temperature limit and we study the effect of the scalar field on the near horizon geometry of an extremal black hole. We find that except a critical value of the charge of the black hole there is also a critical value of the charge of the scalar field beyond of which the extremal black hole is destabilized. We study the thermodynamics of these solutions and we find that if the space is flat then at low temperature the Reissner-Nordstr\\"om black hole is thermodynamically preferred, while if the space is AdS the hairy charged black hole is thermodynamically preferred at low temperature.

  1. Religious Extremism in Pakistan

    Science.gov (United States)

    2014-12-01

    Face (July 2008): 32. 21 Ahmed Rashid , Pakistan on the Brink: The Future of America, Pakistan, and Afghanistan (New York: Viking, 2012). 22 Brian J...promoting extremism. Commentators such as Jessica Stern, Alan Richards, Hussain Haqqani, Ahmed Rashid , and Ali Riaz are a few of the scholars who...www.jstor.org/stable/3183558; See also Ahmed Rashid , Descent Into Chaos: The United States and the Failure of Nation Building in Pakistan, Afghanistan, and

  2. USACE Extreme Sea levels

    Science.gov (United States)

    2014-03-14

    report summarising the results of the research, together with a set of recommendations arising from the research. This report describes progress to...Southampton University at HR Wallingford and subsequent teleconference with Heidi Moritz and Kate White. The notes summarising the findings of the...suggestion was made that we may want to begin talking about extreme water levels separate from storms. Ivan mentioned an analysis of storminess which

  3. Extreme geomagnetically induced currents

    Science.gov (United States)

    Kataoka, Ryuho; Ngwira, Chigomezyo

    2016-12-01

    We propose an emergency alert framework for geomagnetically induced currents (GICs), based on the empirically extreme values and theoretical upper limits of the solar wind parameters and of d B/d t, the time derivative of magnetic field variations at ground. We expect this framework to be useful for preparing against extreme events. Our analysis is based on a review of various papers, including those presented during Extreme Space Weather Workshops held in Japan in 2011, 2012, 2013, and 2014. Large-amplitude d B/d t values are the major cause of hazards associated with three different types of GICs: (1) slow d B/d t with ring current evolution (RC-type), (2) fast d B/d t associated with auroral electrojet activity (AE-type), and (3) transient d B/d t of sudden commencements (SC-type). We set "caution," "warning," and "emergency" alert levels during the main phase of superstorms with the peak Dst index of less than -300 nT (once per 10 years), -600 nT (once per 60 years), or -900 nT (once per 100 years), respectively. The extreme d B/d t values of the AE-type GICs are 2000, 4000, and 6000 nT/min at caution, warning, and emergency levels, respectively. For the SC-type GICs, a "transient alert" is also proposed for d B/d t values of 40 nT/s at low latitudes and 110 nT/s at high latitudes, especially when the solar energetic particle flux is unusually high.

  4. Extremes in nature

    CERN Document Server

    Salvadori, Gianfausto; Kottegoda, Nathabandu T

    2007-01-01

    This book is about the theoretical and practical aspects of the statistics of Extreme Events in Nature. Most importantly, this is the first text in which Copulas are introduced and used in Geophysics. Several topics are fully original, and show how standard models and calculations can be improved by exploiting the opportunities offered by Copulas. In addition, new quantities useful for design and risk assessment are introduced.

  5. The Extreme Climate Index: a novel and multi-hazard index for extreme weather events.

    Science.gov (United States)

    Cucchi, Marco; Petitta, Marcello; Calmanti, Sandro

    2017-04-01

    In this presentation we introduce the Extreme Climate Index (ECI): an objective, multi-hazard index capable of tracking changes in the frequency or magnitude of extreme weather events in African countries, thus indicating that a shift to a new climate regime is underway in a particular area. This index has been developed in the context of XCF (eXtreme Climate Facilities) project lead by ARC (African Risk Capacity, specialised agency of the African Union), and will be used in the payouts triggering mechanism of an insurance programme against risks related to the increase of frequency and magnitude of extreme weather events due to climate regimes' changes. The main hazards covered by ECI will be extreme dry, wet and heat events, with the possibility of adding region-specific risk events such as tropical cyclones for the most vulnerable areas. It will be based on data coming from consistent, sufficiently long, high quality historical records and will be standardized across broad geographical regions, so that extreme events occurring under different climatic regimes in Africa can be comparable. The first step to construct such an index is to define single hazard indicators. In this first study we focused on extreme dry/wet and heat events, using for their description respectively the well-known SPI (Standardized Precipitation Index) and an index developed by us, called SHI (Standardized Heat-waves Index). The second step consists in the development of a computational strategy to combine these, and possibly other indices, so that the ECI can describe, by means of a single indicator, different types of climatic extremes. According to the methodology proposed in this paper, the ECI is defined by two statistical components: the ECI intensity, which indicates whether an event is extreme or not; the angular component, which represent the contribution of each hazard to the overall intensity of the index. The ECI can thus be used to identify "extremes" after defining a

  6. Reliability of structural systems subjected to extreme forcing events

    CERN Document Server

    Joo, Han-Kyul; Sapsis, Themistoklis P

    2016-01-01

    We characterize the complex, heavy-tailed probability distribution functions (pdf) describing the response and its local extrema for structural systems subjected to random forcing that includes extreme events. Our approach is based on the recent probabilistic decomposition-synthesis technique in, where we decouple rare events regimes from the background fluctuations. The result of the analysis has the form of a semi-analytical approximation formula for the pdf of the response (displacement, velocity, and acceleration) and the pdf of the local extrema. For special limiting cases (lightly damped or heavily damped systems) our analysis provides fully analytical approximations. We also demonstrate how the method can be applied to high dimensional structural systems through a two-degrees-of-freedom structural system undergoing rare events due to intermittent forcing. The derived formulas can be evaluated with very small computational cost and are shown to accurately capture the complicated heavy-tailed and asymmet...

  7. Functional proteomic of Matrix Metallo-proteinases (MMP) dedicated to the detection of active forms of MMP in complex proteome; Proteomique fonctionnelle dediee aux Metalloproteases Matricelles (MMPs): developpement d'une methode extremement sensible permettant la detection des formes actives des MMPs dans des proteomes complexes

    Energy Technology Data Exchange (ETDEWEB)

    David, A

    2007-07-15

    The Matrix Metallo-proteinases (M.M.P.) represent a family of Zinc dependent extracellular proteinases able to cleave collectively all the proteins constituting the extracellular matrix. Currently, 23 human M.M.P. have been identified and are characterized by their sequence in amino-acids and their highly conserved 3 D structure. These enzymes are expressed constitutively during the tissue remodeling process. Their over-expression in various diseases tightly related to inflammatory processes (arthritis, emphysema, cancer) described M.M.P. as choice therapeutic targets. However, as the tissue remodeling implicates modification of cellular contacts, M.M.P. appear currently as proteins involved in signalling pathways. Recent works demonstrating that M.M.P. are able to cleave substrates, which are different than proteins constituting the extracellular matrix, reinforce this vision. In order to identify the individual role and the protein expression level of M.M.P. in pathological context, we developed a new technique of functional proteomics dedicated to the detection of active forms of M.M.P. in tumour samples. This technique relied on the development of a new photoaffinity probe, based on the structure of a potent phosphinic inhibitor of M.M.P., allowing targeting and isolating active forms of M.M.P. by photoaffinity labelling. Furthermore, as the new developed probe incorporated a radioactive element, photoaffinity labelling permitted to radiolabel the targeted proteins. This probe demonstrated in vitro its remarkable ability to covalently modify the h M.M.P.-12, with a singular cross-linking yield, determined at 42 %, displaying an extremely sensitive detection (2.5 fmoles of h M.M.P.-12). When added to complex proteome, the photoaffinity probe presents the same sensibility of detection for the h M.M.P.-12 (5 fmoles); importantly, in this case, h M.M.P.-12 represents only 0.001 % of the totality of the proteins present in the sample. Moreover, this technique allows

  8. Lower extremity injuries sustained while farming.

    Science.gov (United States)

    Neil, Janice A

    2002-01-01

    Today's complex farm environment can pose many threats to the lower extremities of all people especially those with chronic diseases that affect the lower extremities. The purpose of this study was to investigate the incidence of injuries to the lower extremities among farmers and to rank the importance of these incidents in order to plan prevention programs. one hundred farmers were surveyed at a large farm show in the southeastern United States. An average of 4.86 injuries per farmer were reported. Blisters from work shoes or boots, followed by injuries from animals stepping on the feet were the most common injuries. Since those with chronic illnesses are especially prone to injury and disability, regular foot assessments, evaluation, and education about the hazards of farming are mainstays of prevention.

  9. Biological Extreme Events - Past, Present, and Future

    Science.gov (United States)

    Gutschick, V. P.

    2010-12-01

    Biological extreme events span wide ranges temporally and spatially and in type - population dieoffs, extinctions, ecological reorganizations, changes in biogeochemical fluxes, and more. Driving variables consist in meteorology, tectonics, orbital changes, anthropogenic changes (land-use change, species introductions, reactive N injection into the biosphere), and evolution (esp. of diseases). However, the mapping of extremes in the drivers onto biological extremes as organismal responses is complex, as laid out originally in the theoretical framework of Gutschick and BassiriRad (New Phytologist [2003] 100:21-42). Responses are nonlinear and dependent on (mostly unknown and) complex temporal sequences - often of multiple environmental variables. The responses are species- and genotype specific. I review extreme events over from past to present over wide temporal scales, while noting that they are not wholly informative of responses to the current and near-future drivers for at least two reasons: 1) the current combination of numerous environmental extremes - changes in CO2, temperature, precipitation, reactive N, land fragmentation, O3, etc. -is unprecedented in scope, and 2) adaptive genetic variation for organismal responses is constrained by poorly-characterized genetic structures (in organisms and populations) and by loss of genetic variation by genetic drift over long periods. We may expect radical reorganizations of ecosystem and biogeochemical functions. These changes include many ecosystem services in flood control, crop pollination and insect/disease control, C-water-mineral cycling, and more, as well as direct effects on human health. Predictions of such changes will necessarily be very weak in the critical next few decades, given the great deal of observation, experimentation, and theory construction that will be necessary, on both organisms and drivers. To make the research efforts most effective will require extensive, insightful planning, beginning

  10. Ergotamine-induced upper extremity ischemia: a case report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Man Deuk; Lee, Gun [Bundang CHA General Hospital, Pochon (China); Shin, Sung Wook [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2005-06-15

    Ergotamine-induced limb ischemia is an extremely rare case. We present a case of a 64-year-old man, who developed ischemia on the right upper extremity due to long-term use of Ergot for migraine headache. Angiography revealed diffused, smooth, and tapered narrowing of the brachial artery. The patient was successfully treated with intravenous nitroprusside.

  11. Conditional simulations for fields of extreme precipitation

    Science.gov (United States)

    Bechler, Aurélien; Vrac, Mathieu; Bel, Liliane

    2014-05-01

    Many environmental models, such as hydrological models, require input data, e.g. precipitation values, correctly simulated and distributed, even at locations where no observation is available. This is particularly true for extreme events that may be of high importance for impact studies. The last decade has seen max-stable processes emerge as a powerful tool for the statistical modeling of spatial extremes. Recently, such processes have been used in climate context to perform simulations at ungauged sites based on empirical distributions of a spatial field conditioned by observed values in some locations. In this work conditional simulations of extremal t process are investigated, taking benefits of its spectral construction. The methodology of conditional simulations proposed by Dombry et al. [2013] for Brown-Resnick and Schlather models is adapted for the extremal t process with some improvements which enlarge the possible number of conditional points. A simulation study enables to highlight the role of the different parameters of the model and to emphasize the importance of the steps of the algorithm. In this work, we focus on the French Mediterranean basin, which is a key spot of occurrences of meteorological extremes such as heavy precipitation. Indeed, major extreme precipitation are regularly observed in this region near the 'cévenol" mountains. The modeling and the understanding of these extreme precipitation - the so-called 'cévenol events" - are of major importance for hydrological studies in this complex terrain since they often trigger major floods in this region. The application of our methodology on real data in this region shows that the model and the algorithm perform well provided the stationary assumptions are fulfilled.

  12. Flooding hazards from sea extremes and subsidence

    DEFF Research Database (Denmark)

    Sørensen, Carlo; Vognsen, Karsten; Broge, Niels

    2015-01-01

    If we do not understand the effects of climate change and sea level rise (SLR) we cannot live in low-lying coastal areas in the future. Permanent inundation may become a prevalent issue but more often floods related to extreme events have the largest damage potential, and the management of flooding...... hazards needs to integrate the water loading from various sources. Furthermore, local subsidence must be accounted for in order to evaluate current and future flooding hazards and management options. We present the methodology (Figure) and preliminary results from the research project “Coastal Flooding...... Hazards due to Storm Surges and Subsidence” (2014-2017) with the objective to develop and test a practice oriented methodology for combining extreme water level statistics and land movement in coastal flooding hazard mapping and in climate change adaptation schemes in Denmark. From extreme value analysis...

  13. Extreme Programming Pocket Guide

    CERN Document Server

    Chromatic

    2003-01-01

    Extreme Programming (XP) is a radical new approach to software development that has been accepted quickly because its core practices--the need for constant testing, programming in pairs, inviting customer input, and the communal ownership of code--resonate with developers everywhere. Although many developers feel that XP is rooted in commonsense, its vastly different approach can bring challenges, frustrations, and constant demands on your patience. Unless you've got unlimited time (and who does these days?), you can't always stop to thumb through hundreds of pages to find the piece of info

  14. Mycetoma of lower extremity

    Directory of Open Access Journals (Sweden)

    Sahariah S

    1978-01-01

    Full Text Available Ten cases of mycetoma of the lower extremity were seen and treated at the Postgraduate Institute of Medical Education & Research, Chandigarh, India, during the years 1973 to 1975. Six were treated by conservative method e.g. antibiotics, sulfonamides and immobilization of the part while remaining four were submitted t o surgery. Four out o f six from the first group had recurrence and has been put on second line of therapy. Recurrence occurred in only one case from the second group and he required an above knee amputation while the remaining three are free of disease and are well rehabilitated.

  15. Characterizing Extreme Ionospheric Storms

    Science.gov (United States)

    Sparks, L.; Komjathy, A.; Altshuler, E.

    2011-12-01

    Ionospheric storms consist of disturbances of the upper atmosphere that generate regions of enhanced electron density typically lasting several hours. Depending upon the storm magnitude, gradients in electron density can sometimes become large and highly localized. The existence of such localized, dense irregularities is a major source of positioning error for users of the Global Positioning System (GPS). Consequently, satellite-based augmentation systems have been implemented to improve the accuracy and to ensure the integrity of user position estimates derived from GPS measurements. Large-scale irregularities generally do not pose a serious threat to estimate integrity as they can be readily detected by such systems. Of greater concern, however, are highly localized irregularities that interfere with the propagation of a signal detected by a user measurement but are poorly sampled by the receivers in the system network. The most challenging conditions have been found to arise following disturbances of large magnitude that occur only rarely over the course of a solar cycle. These extremely disturbed conditions exhibit behavior distinct from moderately disturbed conditions and, hence, have been designated "extreme storms". In this paper we examine and compare the behavior of the extreme ionospheric storms of solar cycle 23 (or, more precisely, extreme storms occurring between January 1, 2000, and December 31, 2008), as represented in maps of vertical total electron content. To identify these storms, we present a robust means of quantifying the regional magnitude of an ionospheric storm. Ionospheric storms are observed frequently to occur in conjunction with magnetic storms, i.e., periods of geophysical activity as measured by magnetometers. While various geomagnetic indices, such as the disturbance storm time (Dst) and the planetary Kp index, have long been used to rank the magnitudes of distinct magnetic storms, no comparable, generally recognized index exists for

  16. Winter Storms and Extreme Cold

    Science.gov (United States)

    ... Landslides & Debris Flow Nuclear Blast Nuclear Power Plants Power Outages Pandemic Radiological Dispersion Device Severe Weather Snowstorms & Extreme ... Landslides & Debris Flow Nuclear Blast Nuclear Power Plants Power Outages Pandemic Radiological Dispersion Device Severe Weather Snowstorms & Extreme ...

  17. Comparative outcome of bomb explosion injuries versus high-powered gunshot injuries of the upper extremity in a civilian setting.

    Science.gov (United States)

    Luria, Shai; Rivkin, Gurion; Avitzour, Malka; Liebergall, Meir; Mintz, Yoav; Mosheiff, Ram

    2013-03-01

    Explosion injuries to the upper extremity have specific clinical characteristics that differ from injuries due to other mechanisms. To evaluate the upper extremity injury pattern of attacks on civilian targets, comparing bomb explosion injuries to gunshot injuries and their functional recovery using standard outcome measures. Of 157 patients admitted to the hospital between 2000 and 2004, 72 (46%) sustained explosion injuries and 85 (54%) gunshot injuries. The trauma registry files were reviewed and the patients completed the DASH Questionnaire (Disabilities of Arm, Shoulder and Hand) and SF-12 (Short Form-12) after a minimum period of 1 year. Of the 157 patients, 72 (46%) had blast injuries and 85 (54%) had shooting injuries. The blast casualties had higher Injury Severity Scores (47% vs. 22% with a score of > 16, P = 0.02) and higher percent of patients treated in intensive care units (47% vs. 28%, P = 0.02). Although the Abbreviated Injury Scale score of the upper extremity injury was similar in the two groups, the blast casualties were found to have more bilateral and complex soft tissue injuries and were treated surgically more often. No difference was found in the SF-12 or DASH scores between the groups at follow up. The casualties with upper extremity blast injuries were more severely injured and sustained more bilateral and complex soft tissue injuries to the upper extremity. However, the rating of the local injury to the isolated limb is similar, as was the subjective functional recovery.

  18. Extreme Scale Visual Analytics

    Energy Technology Data Exchange (ETDEWEB)

    Steed, Chad A [ORNL; Potok, Thomas E [ORNL; Pullum, Laura L [ORNL; Ramanathan, Arvind [ORNL; Shipman, Galen M [ORNL; Thornton, Peter E [ORNL; Potok, Thomas E [ORNL

    2013-01-01

    Given the scale and complexity of today s data, visual analytics is rapidly becoming a necessity rather than an option for comprehensive exploratory analysis. In this paper, we provide an overview of three applications of visual analytics for addressing the challenges of analyzing climate, text streams, and biosurveilance data. These systems feature varying levels of interaction and high performance computing technology integration to permit exploratory analysis of large and complex data of global significance.

  19. Chicago, IL Adapts to Improve Extreme Heat Preparedness

    Science.gov (United States)

    Recognizing that heat waves are expected to increase in Chicago due to climate change,–supported by the Chicago Climate Impacts Report, the city adopted a comprehensive set of actions to reduce deaths from extreme heat events.

  20. Plasmonic hole arrays with extreme optical chirality in linear and nonlinear regimes

    Science.gov (United States)

    Gorkunov, Maxim V.; Kondratov, Alexei V.; Darinskii, Alexander N.; Artemov, Vladimir V.; Rogov, Oleg Y.; Gainutdinov, Radmir V.

    2016-04-01

    Metamaterials with high optical activity (OA) and circular dichroism (CD) are desired for various prospective applications ranging from circular light polarizing to enhanced chiral sensing and biosensing. Modern techniques allow fabricating subwavelength arrays of holes of complex chiral shapes that exhibit extreme optical chirality: their OA and CD take the whole range of possible values in the visible. In order to understand the nature of extreme chirality, we performed the electromagnetic finite difference time domain simulations for the hole shapes resolved by atomic force microscopy. The analysis of the simulation data allowed us to develop an analytical chiral coupled-mode model that nicely fits the results and explains the extreme chirality as determined by the Fano-type transmission resonance due to the interference of a weak background channel and a resonant plasmon channel. The model shows critical importance of the dissipation losses, the hole shape symmetry and chirality. In a planar 2D-chiral hole array, the mirror asymmetry can be induced by the difference of dielectric materials adjacent to the array sides and even their weak deviation results in remarkably strong OA and CD. We note that such deviations can arise due to the dielectric nonlinearity and discuss how 2D-chiral metamaterials in symmetric environment can acquire optical chirality due to the nonlinear symmetry breaking.

  1. Refractory Epistaxis due to Severe Factor V Deficiency with Inhibitor

    Directory of Open Access Journals (Sweden)

    Elizabeth S. John

    2015-01-01

    Full Text Available Factor V deficiency secondary to inhibitors is extremely rare and can be caused by a wide collection of exposures such as bovine thrombin and beta lactamase antibiotics. The management of factor V deficiency with inhibitor is a condition treated based on case reports due to the rarity of this condition. We describe a complicated case of an elderly patient with severe factor V deficiency with high inhibitor titer refractory to FEIBA (anti-inhibitor coagulation complex treated with NovoSeven concurrently with cyclosporine immunosuppression and Rituxan. Given that there are no consensus guidelines on treatment, this case offers important insight into the therapeutic approaches that can be used to treat such patients.

  2. Examining global extreme sea level variations on the coast from in-situ and remote observations

    Science.gov (United States)

    Menendez, Melisa; Benkler, Anna S.

    2017-04-01

    The estimation of extreme water level values on the coast is a requirement for a wide range of engineering and coastal management applications. In addition, climate variations of extreme sea levels on the coastal area result from a complex interacting of oceanic, atmospheric and terrestrial processes across a wide range of spatial and temporal scales. In this study, variations of extreme sea level return values are investigated from two available sources of information: in-situ tide-gauge records and satellite altimetry data. Long time series of sea level from tide-gauge records are the most valuable observations since they directly measure water level in a specific coastal location. They have however a number of sources of in-homogeneities that may affect the climate description of extremes when this data source is used. Among others, the presence of gaps, historical time in-homogeneities and jumps in the mean sea level signal are factors that can provide uncertainty in the characterization of the extreme sea level behaviour. Moreover, long records from tide-gauges are sparse and there are many coastal areas worldwide without in-situ available information. On the other hand, with the accumulating altimeter records of several satellite missions from the 1990s, approaching 25 recorded years at the time of writing, it is becoming possible the analysis of extreme sea level events from this data source. Aside the well-known issue of altimeter measurements very close to the coast (mainly due to corruption by land, wet troposphere path delay errors and local tide effects on the coastal area), there are other aspects that have to be considered when sea surface height values estimated from satellite are going to be used in a statistical extreme model, such as the use of a multi-mission product to get long observed periods and the selection of the maxima sample, since altimeter observations do not provide values uniform in time and space. Here, we have compared the extreme

  3. Communication complexity and information complexity

    Science.gov (United States)

    Pankratov, Denis

    complexity of two of the most studied functions in the communication complexity literature: Gap Hamming Distance (GHD) and Inner Product mod 2 (IP). In our first result we affirm the conjecture that the information complexity of GHD is linear even under the uniform distribution. This strengthens the O(n) bound shown by Kerenidis et al. (2012) and answers an open problem by Chakrabarti et al. (2012). We also prove that the information complexity of IP is arbitrarily close to the trivial upper bound n as the permitted error tends to zero, again strengthening the O(n) lower bound proved by Braverman and Weinstein (2011). More importantly, our proofs demonstrate that self-reducibility makes the connection between information complexity and communication complexity lower bounds a two-way connection. Whereas numerous results in the past used information complexity techniques to derive new communication complexity lower bounds, we explore a generic way, in which communication complexity lower bounds imply information complexity lower bounds in a black-box manner. In the third contribution we consider the roles that private and public randomness play in the definition of information complexity. In communication complexity, private randomness can be trivially simulated by public randomness. Moreover, the communication cost of simulating public randomness with private randomness is well understood due to Newman's theorem (1991). In information complexity, the roles of public and private randomness are reversed: public randomness can be trivially simulated by private randomness. However, the information cost of simulating private randomness with public randomness is not understood. We show that protocols that use only public randomness admit a rather strong compression. In particular, efficient simulation of private randomness by public randomness would imply a version of a direct sum theorem in the setting of communication complexity. This establishes a yet another connection between

  4. Acquired Upper Extremity Growth Arrest.

    Science.gov (United States)

    Gauger, Erich M; Casnovsky, Lauren L; Gauger, Erica J; Bohn, Deborah C; Van Heest, Ann E

    2017-01-01

    This study reviewed the clinical history and management of acquired growth arrest in the upper extremity in pediatric patients. The records of all patients presenting from 1996 to 2012 with radiographically proven acquired growth arrest were reviewed. Records were examined to determine the etiology and site of growth arrest, management, and complications. Patients with tumors or hereditary etiology were excluded. A total of 44 patients (24 boys and 20 girls) with 51 physeal arrests who presented at a mean age of 10.6 years (range, 0.8-18.2 years) were included in the study. The distal radius was the most common site (n=24), followed by the distal humerus (n=8), metacarpal (n=6), distal ulna (n=5), proximal humerus (n=4), radial head (n=3), and olecranon (n=1). Growth arrest was secondary to trauma (n=22), infection (n=11), idiopathy (n=6), inflammation (n=2), compartment syndrome (n=2), and avascular necrosis (n=1). Twenty-six patients (59%) underwent surgical intervention to address deformity caused by the physeal arrest. Operative procedures included ipsilateral unaffected bone epiphysiodesis (n=21), shortening osteotomy (n=10), lengthening osteotomy (n=8), excision of physeal bar or bone fragment (n=2), angular correction osteotomy (n=1), and creation of single bone forearm (n=1). Four complications occurred; 3 of these required additional procedures. Acquired upper extremity growth arrest usually is caused by trauma or infection, and the most frequent site is the distal radius. Growth disturbances due to premature arrest can be treated effectively with epiphysiodesis or osteotomy. In this series, the specific site of anatomic growth arrest was the primary factor in determining treatment. [Orthopedics. 2017; 40(1):e95-e103.]. Copyright 2016, SLACK Incorporated.

  5. The results of nationwide survey efficiency of the complex acetyl-L-carnitine and L-carnitine fumarate in the treatment of infertile marriages due to the presence of male factor

    Directory of Open Access Journals (Sweden)

    I. V. Vinogradov

    2014-12-01

    Full Text Available The article studies the influence of a complex of acetyl-L-carnitine and L-carnitine fumarate in combination therapy qualitative and quantitative indicators of sperm in men with various forms pathospermia. The study has shown that such improved performance as morphology, motility and concentration. It turned out that the treatment of complex drugs carnitine series allows you to have a spouse patients natural pregnancyin 29.57 % of cases, which does not exclude the use of drugs containing acetyl-L-carnitine and L-carnitine fumarate in preparing men to assisted reproductive technologies programs.

  6. Precipitation extremes under climate change

    CERN Document Server

    O'Gorman, Paul A

    2015-01-01

    The response of precipitation extremes to climate change is considered using results from theory, modeling, and observations, with a focus on the physical factors that control the response. Observations and simulations with climate models show that precipitation extremes intensify in response to a warming climate. However, the sensitivity of precipitation extremes to warming remains uncertain when convection is important, and it may be higher in the tropics than the extratropics. Several physical contributions govern the response of precipitation extremes. The thermodynamic contribution is robust and well understood, but theoretical understanding of the microphysical and dynamical contributions is still being developed. Orographic precipitation extremes and snowfall extremes respond differently from other precipitation extremes and require particular attention. Outstanding research challenges include the influence of mesoscale convective organization, the dependence on the duration considered, and the need to...

  7. "Triangular" extremal dilatonic dyons

    CERN Document Server

    Gal'tsov, Dmitri; Orlov, Dmitri

    2014-01-01

    Explicit dyonic dilaton black holes of the four-dimensional Einstein-Maxwell-dilaton theory are known only for two particular values of the dilaton coupling constant $a =1,\\sqrt{3}$, while for other $a$ numerical evidence was presented earlier about existence of extremal dyons in theories with the discrete sequence of dilaton couplings $a=\\sqrt{n(n+1)/2}$ with integer $n$. Apart from the lower members $n=1,\\,2$, this family of theories does not have motivation from supersymmetry or higher dimensions, and so far the above quantization rule has not been derived analytically. We fill this gap showing that this rule follows from analyticity of the dilaton at the $AdS_2\\times S^2$ event horizon with $n$ being the leading dilaton power in the series expansion. We also present generalization for asymptotically anti-de Sitter dyonic black holes with spherical, plane and hyperbolic topology of the horizon.

  8. Extreme skin depth waveguides

    CERN Document Server

    Jahani, Saman

    2014-01-01

    Recently, we introduced a paradigm shift in light confinement strategy and introduced a class of extreme skin depth (e-skid) photonic structures (S. Jahani and Z. Jacob, "Transparent sub-diffraction optics: nanoscale light confinement without metal," Optica 1, 96-100 (2014)). Here, we analytically establish that figures of merit related to light confinement in dielectric waveguides are fundamentally tied to the skin depth of waves in the cladding. We contrast the propagation characteristics of the fundamental mode of e-skid waveguides and conventional waveguides to show that the decay constant in the cladding is dramatically larger in e-skid waveguides, which is the origin of sub-diffraction confinement. Finally, we propose an approach to verify the reduced skin depth in experiment using the decrease in the Goos-H\\"anchen phase shift.

  9. Pulsars and Extreme Physics

    Science.gov (United States)

    Bell-Burnell, Jocelyn

    2004-10-01

    Pulsars were discovered 35 years ago. What do we know about them now, and what have they taught us about the extremes of physics? With an average density comparable to that of the nucleus, magnetic fields around 108 T and speeds close to c these objects have stretched our understanding of the behaviour of matter. They serve as extrememly accurate clocks with which to carry out precision experiments in relativity. Created in cataclysmic explosions, pulsars are a (stellar) form of life after death. After half a billion revolutions most pulsars finally die, but amazingly some are born again to yet another, even weirder, afterlife. Pulsar research continues lively, delivering exciting, startling and almost unbelievable results!

  10. On Predictive Understanding of Extreme Events: Pattern Recognition Approach; Prediction Algorithms; Applications to Disaster Preparedness

    Science.gov (United States)

    Keilis-Borok, V. I.; Soloviev, A.; Gabrielov, A.

    2011-12-01

    We describe a uniform approach to predicting different extreme events, also known as critical phenomena, disasters, or crises. The following types of such events are considered: strong earthquakes; economic recessions (their onset and termination); surges of unemployment; surges of crime; and electoral changes of the governing party. A uniform approach is possible due to the common feature of these events: each of them is generated by a certain hierarchical dissipative complex system. After a coarse-graining, such systems exhibit regular behavior patterns; we look among them for "premonitory patterns" that signal the approach of an extreme event. We introduce methodology, based on the optimal control theory, assisting disaster management in choosing optimal set of disaster preparedness measures undertaken in response to a prediction. Predictions with their currently realistic (limited) accuracy do allow preventing a considerable part of the damage by a hierarchy of preparedness measures. Accuracy of prediction should be known, but not necessarily high.

  11. Antenna diagnostics for power flow in extreme near-field of a standard gain horn

    DEFF Research Database (Denmark)

    Popa, Paula Irina; Breinbjerg, Olav

    2016-01-01

    The plane wave spectrum of an aperture antenna can be calculated from a complex measurement of the radiated near- or far-field and it facilitates antenna diagnostics for the extreme near-field of the antenna. While antenna diagnostics often concerns the magnitude of the co-polar field, the plane...... wave spectrum actually allows for determination of both magnitude and phase of all three components of the electric as well as the magnetic field - and thus also the Poynting vector. In this work we focus on the Poynting vector and thus the power flow in the extreme near-field; as an example we employ...... that these oscillations are not merely a “Gibbs-like” phenomenon due to the availability of only the visible region of the plane wave spectrum and they are not caused by multiple reflections between the horn and the near-field probe - but resulted from the interference between the direct field and the edge...

  12. Daily extreme temperature multifractals in Catalonia (NE Spain)

    Energy Technology Data Exchange (ETDEWEB)

    Burgueño, A. [Departament d' Astronomia i Meteorologia, Universitat de Barcelona, Barcelona (Spain); Lana, X., E-mail: francisco.javier.lana@upc.edu [Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Barcelona (Spain); Serra, C. [Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Barcelona (Spain); Martínez, M.D. [Departament de Física Aplicada, Universitat Politècnica de Catalunya, Barcelona (Spain)

    2014-02-01

    The multifractal character of the daily extreme temperatures in Catalonia (NE Spain) is analyzed by means of the multifractal detrended fluctuation analysis (MF-DFA) applied to 65 thermometric records covering years 1950–2004. Although no clear spatial patterns of the multifractal spectrum parameters appear, factor scores deduced from Principal Component analysis indicate some signs of spatial gradients. Additionally, the daily extreme temperature series are classified depending on their complex time behavior, through four multifractal parameters (Hurst exponent, Hölder exponent with maximum spectrum, spectrum asymmetry and spectrum width). As a synthesis of the three last parameters, a basic measure of complexity is proposed through a normalized Complexity Index. Its regional behavior is found to be free of geographical dependences. This index represents a new step towards the description of the daily extreme temperatures complexity.

  13. Women in extreme poverty.

    Science.gov (United States)

    1994-01-01

    Population is estimated to increase from 5.5 billion in 1990 to 10 billion by 2050; the poverty level is expected to increase from 1 billion to 2-3 billion people. Women in development has been promoted throughout the UN and development system, but women in poverty who perform work in the informal sector are still uncounted, and solutions are elusive. The issue of extreme poverty can not be approached as just another natural disaster with immediate emergency relief. Many people live in precarious economic circumstances throughout their lives. Recent research reveals a greater understanding of the underlying causes and the need for inclusion of poor women in sustainable development. Sanitation, water, housing, health facilities need to be improved. Women must have access to education, opportunities for trading, and loans on reasonable terms. UNESCO makes available a book on survival strategies for poor women in the informal sector. The profile shows common problems of illiteracy, broken marriages, and full time involvement in provision of subsistence level existence. Existence is a fragile balance. Jeanne Vickers' "Women and the World" offers simple, low cost interventions for aiding extremely poor women. The 1992 Commission on the Status of Women was held in Vienna. Excerpts from several speeches are provided. The emphasis is on some global responses and an analysis of solutions. The recommendation is for attention to the gender dimension of poverty. Women's dual role contributes to greater disadvantages. Women are affected differently by macroeconomic factors, and that there is intergenerational transfer of poverty. Social services should be viewed as investments and directed to easing the burdens on time and energy. Public programs must be equipped to deal with poverty and to bring about social and economic change. Programs must be aware of the different distribution of resources within households. Women must be recognized as principal economic providers within

  14. Extreme winds in Denmark

    Energy Technology Data Exchange (ETDEWEB)

    Kristensen, L.; Rathmann, O.; Hansen, S.O.

    1999-02-01

    Wind-speed data from four sites in Denmark have been analyzed in order to obtain estimates of the basic wind velocity which is defined as the 50-year wind speed under standard conditions, i.e. ten-minute averages at the height 10 m over a uniform terrain with the roughness length 0.05 m. The sites are, from west, Skjern (15 years), Kegnaes (7 years), Sprogoe (20 years), and Tystofte (15 years). The data are ten minute averages of wind speed, wind direction, temperature and pressure. The last two quantities are used to determine the air density {rho}. The data are cleaned for terrain effects by means of a slightly modified WASP technique where the sector speed-up factors and roughness lengths are linearly smoothed with a direction resolution of one degree. Assuming geotropic balance, all the wind-velocity data are transformed to friction velocity u{sub *} and direction at standard conditions by means of the geotropic drag law for neutral stratification. The basic wind velocity in 30 deg. sectors are obtained through ranking of the largest values of the friction velocity pressure 1/2{rho}u{sub *}{sup 2} taken both one every two months and once every year. The main conclusion is that the basic wind velocity is significantly larger at Skjern, close to the west coast of Jutland, than at any of the other sites. Irrespective of direction, the present standard estimates of 50-year wind are 25 {+-} 1 m/s at Skern and 22 {+-} 1 m/s at the other three sites. These results are in agreement with those obtained by Jensen and Franck (1970) and Abild (1994) and supports the conclusion that the wind climate at the west coast of Jutland is more extreme than in any other part of the country. Simple procedures to translate in a particular direction sector the standard basic wind velocity to conditions with a different roughness length and height are presented. It is shown that a simple scheme makes it possible to calculate the total 50-year extreme load on a general structure without

  15. Extreme Rainfall Events Over Southern Africa: Assessment of a Climate Model to Reproduce Daily Extremes

    Science.gov (United States)

    Williams, C.; Kniveton, D.; Layberry, R.

    2007-12-01

    It is increasingly accepted that any possible climate change will not only have an influence on mean climate but may also significantly alter climatic variability. This issue is of particular importance for environmentally vulnerable regions such as southern Africa. The subcontinent is considered especially vulnerable extreme events, due to a number of factors including extensive poverty, disease and political instability. Rainfall variability and the identification of rainfall extremes is a function of scale, so high spatial and temporal resolution data are preferred to identify extreme events and accurately predict future variability. The majority of previous climate model verification studies have compared model output with observational data at monthly timescales. In this research, the assessment of a state-of-the-art climate model to simulate climate at daily timescales is carried out using satellite derived rainfall data from the Microwave Infra-Red Algorithm (MIRA). This dataset covers the period from 1993-2002 and the whole of southern Africa at a spatial resolution of 0.1 degree longitude/latitude. Once the model's ability to reproduce extremes has been assessed, idealised regions of SST anomalies are used to force the model, with the overall aim of investigating the ways in which SST anomalies influence rainfall extremes over southern Africa. In this paper, results from sensitivity testing of the UK Meteorological Office Hadley Centre's climate model's domain size are firstly presented. Then simulations of current climate from the model, operating in both regional and global mode, are compared to the MIRA dataset at daily timescales. Thirdly, the ability of the model to reproduce daily rainfall extremes will be assessed, again by a comparison with extremes from the MIRA dataset. Finally, the results from the idealised SST experiments are briefly presented, suggesting associations between rainfall extremes and both local and remote SST anomalies.

  16. Solar extreme events

    CERN Document Server

    Hudson, Hugh S

    2015-01-01

    Solar flares and CMEs have a broad range of magnitudes. This review discusses the possibility of "extreme events," defined as those with magnitudes greater than have been seen in the existing historical record. For most quantitative measures, this direct information does not extend more than a century and a half into the recent past. The magnitude distributions (occurrence frequencies) of solar events (flares/CMEs) typically decrease with the parameter measured or inferred (peak flux, mass, energy etc. Flare radiation fluxes tend to follow a power law slightly flatter than $S^{-2}$, where S represents a peak flux; solar particle events (SPEs) follow a still flatter power law up to a limiting magnitude, and then appear to roll over to a steeper distribution, which may take an exponential form or follow a broken power law. This inference comes from the terrestrial $^{14}$C record and from the depth dependence of various radioisotope proxies in the lunar regolith and in meteorites. Recently major new observation...

  17. Extremal almost-Kahler metrics

    CERN Document Server

    Lejmi, Mehdi

    2009-01-01

    We generalize the notion of the Futaki invariant and extremal vector field to the general almost-Kahler case and we prove the periodicity of the extremal vector field when the symplectic form represents an integral cohomology class modulo torsion. We give also an explicit formula of the hermitian scalar curvature which allows us to obtain examples of non-integrable extremal almost-Kahler metrics saturating LeBrun's estimates.

  18. Upper extremity amputations and prosthetics.

    Science.gov (United States)

    Ovadia, Steven A; Askari, Morad

    2015-02-01

    Upper extremity amputations are most frequently indicated by severe traumatic injuries. The location of the injury will determine the level of amputation. Preservation of extremity length is often a goal. The amputation site will have important implications on the functional status of the patient and options for prosthetic reconstruction. Advances in amputation techniques and prosthetic reconstructions promote improved quality of life. In this article, the authors review the principles of upper extremity amputation, including techniques, amputation sites, and prosthetic reconstructions.

  19. Life Threatening Complication during Treatment of Erysipelas due to Undiagnosed Ischemia of the Calf

    Directory of Open Access Journals (Sweden)

    Tomasz Brzeziński

    2009-01-01

    Full Text Available Erysipelas is a superficial skin infection due to streptococci strains, which usually responds well to conservative treatment. Coexisting undiagnosed ischemia of the extremity may lead to severe complications. 57-year-old man developed large, circumflex ulceration of his right calf within two weeks before the admission after three-month treatment of erysipelas. Computer angiography showed chronic occlusion of the superficial femoral artery and the above knee popliteal artery. Rapid debridement of the wound took control over the infection. Patient required complex vascular procedure which allowed to prepare the ulcer for meshed skin grafts. Patient was discharged home on 64th hospital day with completely healed ulcer.

  20. Likelihood estimators for multivariate extremes

    KAUST Repository

    Huser, Raphaël

    2015-11-17

    The main approach to inference for multivariate extremes consists in approximating the joint upper tail of the observations by a parametric family arising in the limit for extreme events. The latter may be expressed in terms of componentwise maxima, high threshold exceedances or point processes, yielding different but related asymptotic characterizations and estimators. The present paper clarifies the connections between the main likelihood estimators, and assesses their practical performance. We investigate their ability to estimate the extremal dependence structure and to predict future extremes, using exact calculations and simulation, in the case of the logistic model.

  1. Diplopia due to Dacryops

    OpenAIRE

    Rahmi Duman; Reşat Duman; Mehmet Balcı

    2013-01-01

    Dacryops is a lacrimal ductal cyst. It is known that it can cause globe displacement, motility restriction, and proptosis because of the mass effect. Diplopia due to dacryops has not been reported previously. Here, we present a 57-year-old man with binocular horizontal diplopia that occurred during left direction gaze due to dacryops.

  2. Diplopia due to Dacryops

    Directory of Open Access Journals (Sweden)

    Rahmi Duman

    2013-01-01

    Full Text Available Dacryops is a lacrimal ductal cyst. It is known that it can cause globe displacement, motility restriction, and proptosis because of the mass effect. Diplopia due to dacryops has not been reported previously. Here, we present a 57-year-old man with binocular horizontal diplopia that occurred during left direction gaze due to dacryops.

  3. Extreme Convective Weather in Future Decades

    Science.gov (United States)

    Gadian, Alan; Burton, Ralph; Groves, James; Blyth, Alan; Warner, James; Holland, Greg; Bruyere, Cindy; Done, James; Thielen, Jutta

    2016-04-01

    WISER (Weather Climate Change Impact Study at Extreme Resolution) is a project designed to analyse changes in extreme weather events in a future climate, using a weather model (WRF) which is able to resolve small scale processes. Use of a weather model is specifically designed to look at convection which is of a scale which cannot be resolved by climate models. The regional meso-scale precipitation events, which are critical in understanding climate change impacts will be analysed. A channel domain outer model, with a resolution of ~ 20km in the outer domain drives an inner domain of ~ 3 km resolution. Results from 1989-1994 and 2020-2024 and 2030-2034 will be presented to show the effects of extreme convective events over Western Europe. This presentation will provide details of the project. It will present data from the 1989-1994 ERA-interim and CCSM driven simulations, with analysis of the future years as defined above. The representation of pdfs of extreme precipitation, Outgoing Longwave Radiation and wind speeds, with preliminary comparison with observations will be discussed. It is also planned to use the output to drive the EFAS (European Flood model) to examine the predicted changes in quantity and frequency of severe and hazardous convective rainfall events and leading to the frequency of flash flooding due to heavy convective precipitation.

  4. Plasma Physics of Extreme Astrophysical Environments

    CERN Document Server

    Uzdensky, Dmitri A

    2014-01-01

    Certain classes of astrophysical objects, namely magnetars and central engines of supernovae and gamma-ray bursts (GRBs), are characterized by extreme physical conditions not encountered elsewhere in the Universe. In particular, they possess magnetic fields that exceed the critical quantum field of 44 teragauss. Figuring out how these complex ultra-magnetized systems work requires understanding various plasma processes, both small-scale kinetic and large-scale magnetohydrodynamic (MHD). However, an ultra-strong magnetic field modifies the underlying physics to such an extent that many relevant plasma-physical problems call for building QED-based relativistic quantum plasma physics. In this review, after describing the extreme astrophysical systems of interest and identifying the key relevant plasma-physical problems, we survey the recent progress in the development of such a theory. We discuss how a super-critical field modifies the properties of vacuum and matter and outline the basic theoretical framework f...

  5. Abnormalities of the upper extremities on fetal magnetic resonance imaging.

    Science.gov (United States)

    Nemec, S F; Kasprian, G; Brugger, P C; Bettelheim, D; Amann, G; Nemec, U; Rotmensch, S; Graham, J M; Rimoin, D L; Lachman, R S; Prayer, D

    2011-11-01

    In view of the increasing use of fetal magnetic resonance imaging (MRI) as an adjunct to prenatal ultrasonography, we sought to demonstrate the visualization of upper extremity abnormalities and associated defects on MRI, with regard to fetal outcomes and compared with ultrasound imaging. This retrospective study included 29 fetuses with upper extremity abnormalities visualized with fetal MRI following suspicious ultrasound findings and confirmed by postnatal assessment or autopsy. On a 1.5-Tesla unit, dedicated sequences were applied to image the extremities. Central nervous system (CNS) and extra-CNS anomalies were assessed to define extremity abnormalities as isolated or as complex, with associated defects. Fetal outcome was identified from medical records. MRI and ultrasound findings, when available, were compared. Isolated upper extremity abnormalities were found in three (10.3%) fetuses. In 26 (89.7%) fetuses complex abnormalities, including postural extremity disorders (21/26) and structural extremity abnormalities (15/26), were demonstrated. Associated defects involved: face (15/26); musculoskeletal system (14/26); thorax and cardio/pulmonary system (12/26); lower extremities (12/26); brain and skull (10/26); and abdomen (8/26). Of the 29 cases, 18 (62.1%) pregnancies were delivered and 11 (37.9%) were terminated. MRI and US findings were compared in 27/29 cases: the diagnosis was concordant in 14 (51.9%) of these cases, and additional findings were made on MRI in 13/27 (48.1%) cases. Visualization of upper extremity abnormalities on fetal MRI enables differentiation between isolated defects and complex ones, which may be related to poor fetal prognosis. MRI generally confirms the ultrasound diagnosis, and may provide additional findings in certain cases. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.

  6. Lower extremity lipedema, upper extremity lipodystrophy and severe calcinosis complicating juvenile dermatomyositis.

    Science.gov (United States)

    Pavlov-Dolijanovic, Slavica R; Vujasinovic Stupar, Nada Z; Gavrilov, Nikola; Seric, Srdjan

    2014-11-01

    Juvenile dermatomyositis (JDM) is a rare but complex and potentially life-threatening autoimmune disease of childhood. Significant proportions of patients have residual weakness, muscle atrophy, joint contractures, and calcinosis. Recently, new clinical findings, such as lipodystrophy accompanied with increased fat deposition in certain areas, have been reported. So far, it is not known whether the redistribution of body fat may be the type of lipedema of lower extremity. We describe a 39-year-old woman who was diagnosed with JDM at the age of 7. Later she developed symmetrical lipodystrophy of upper extremities and symmetrical lipedema of lower extremities (making 2 and 58.3 % of total body fat mass, respectively), with multiple calcified nodules in the subcutaneous tissues. These nodules gradually increased in size despite therapy. Capillaroscopy findings showed scleroderma-like abnormalities. ANA and anti-U1RNP antibodies were positive. Similar cases with simultaneous occurrence of the lipedema of lower extremities, lipodystrophy of upper extremities, and severe calcinosis complicating JDM have not been published so far. We showed that the calcinosis and lipodystrophy were associated with short duration of active disease. Also, we display case that raises the question whether it is possible overlapping autoimmune diseases revealed during follow-up.

  7. The Climatology of Taiwan extreme rainfall events and the attributions

    Science.gov (United States)

    Su, S. H.; Kuo, H. C.; Chen, Y. H.; Chu, J. L.; Lin, L. Y.

    2015-12-01

    Taiwan is located in the East-Asian monsoon region with average 2,500mm annual precipitation. Most significant Meteorological disasters are related to extreme precipitation which is associated with a complex terrain. Therefore, the long-term trends or climate variations in precipitation due to climate change are our major concern. We studied the climatology of extreme rainfall (ER, 95thpercentile) events in Taiwan using hourly precipitation data form 21 surface stations during 1960-2014. ER contributes about 40% of the total rain amount. It was found that approximately 68% of ER is related to typhoon (TY) and 22% associated with the Mei-Yu (MY) frontal system. The total ER amount annual variation is strongly related to TY, with correlation coefficient of 0.89 for rainfall amount and 0.86 for frequency. There is a significant increasing trend of TY-ER in past 55 years, but also has large variations over the annual and decadal time scales. The inter-annual variation of astounding extreme rainfall (AER, 99.9thpercentile) is increased significantly, especially in the past 15 years. It implies that the increasing of AER rainfall amount majorly caused by the increasing of frequency instead of average rain intensity of TY-AER. The MY-ER events are also highly correlated with the frontal system. The correlation is 0.84 for the rainfall amount and 0.83 of the frequency with the frontal days. There are also strong inter-annual variations of MY-ER, but the long-term trends are not as significant as TY-ER. The variation of frontal system number is another parameter may impact the MY-ER. The observational frontal system numbers had positive correlation with the MY-ER. The attribution of Taiwan TY-ER changes was debated in the research community. In general, the public acceptance of Taiwan extreme precipitation events is affected by multi-scale systems. According to observational data, the increasing of TY-ER amount is 37 % (48% )in Taiwan and some resent studies (Wang et al

  8. E.X.T.R.E.M.E. project. Launch; Projet EXTREME. Rapport de lancement

    Energy Technology Data Exchange (ETDEWEB)

    Eyrolle, F.; Charmasson, S.; Masson, O

    2005-07-01

    Due to the drastic decrease in artificial radioactivity levels from primary sources such as atmospheric fallout or industrial releases, radioactive storages constituted in the past within several environmental compartments act today as non negligible secondary sources. These delayed sources are particularly active during extreme weather or climatic events such as rainfalls or atmospheric deposits, floods, storms, etc...that may remove important mass, generate activity levels higher than the predicted ones from modeling based on mean transfer process, and produce in a couple of hours or days fluxes similar to those accrued over several month or years. Extreme aims at assessing the consequences on man and its environment of natural events that generate extreme radioactive stocks and/or fluxes within several environmental compartments (atmosphere, soils, rivers, coastal marine environment and deep sea areas). (authors)

  9. A dependence modelling study of extreme rainfall in Madeira Island

    Science.gov (United States)

    Gouveia-Reis, Délia; Guerreiro Lopes, Luiz; Mendonça, Sandra

    2016-08-01

    The dependence between variables plays a central role in multivariate extremes. In this paper, spatial dependence of Madeira Island's rainfall data is addressed within an extreme value copula approach through an analysis of maximum annual data. The impact of altitude, slope orientation, distance between rain gauge stations and distance from the stations to the sea are investigated for two different periods of time. The results obtained highlight the influence of the island's complex topography on the spatial distribution of extreme rainfall in Madeira Island.

  10. Attitude extremity, consensus and diagnosticity

    NARCIS (Netherlands)

    van der Pligt, J.; Ester, P.; van der Linden, J.

    1983-01-01

    Studied the effects of attitude extremity on perceived consensus and willingness to ascribe trait terms to others with either pro- or antinuclear attitudes. 611 Ss rated their attitudes toward nuclear energy on a 5-point scale. Results show that attitude extremity affected consensus estimates. Trait

  11. Grassland responses to precipitation extremes

    Science.gov (United States)

    Grassland ecosystems are naturally subjected to periods of prolonged drought and sequences of wet years. Climate change is expected to enhance the magnitude and frequency of extreme events at the intraannual and multiyear scales. Are grassland responses to extreme precipitation simply a response to ...

  12. Maternal mortality due to trauma.

    Science.gov (United States)

    Romero, Vivian Carolina; Pearlman, Mark

    2012-02-01

    Maternal mortality is an important indicator of adequacy of health care in our society. Improvements in the obstetric care system as well as advances in technology have contributed to reduction in maternal mortality rates. Trauma complicates up to 7% of all pregnancies and has emerged as the leading cause of maternal mortality, becoming a significant concern for the public health system. Maternal mortality secondary to trauma can often be prevented by coordinated medical care, but it is essential that caregivers recognize the unique situation of providing simultaneous care to 2 patients who have a complex physiologic relationship. Optimal management of the pregnant trauma victim requires a multidisciplinary team, where the obstetrician plays a central role. This review focuses on the incidence of maternal mortality due to trauma, the mechanisms involved in traumatic injury, the important anatomic and physiologic changes that may predispose to mortality due to trauma, and finally, preventive strategies that may decrease the incidence of traumatic maternal death.

  13. Modeling extreme risks in ecology.

    Science.gov (United States)

    Burgman, Mark; Franklin, James; Hayes, Keith R; Hosack, Geoffrey R; Peters, Gareth W; Sisson, Scott A

    2012-11-01

    Extreme risks in ecology are typified by circumstances in which data are sporadic or unavailable, understanding is poor, and decisions are urgently needed. Expert judgments are pervasive and disagreements among experts are commonplace. We outline approaches to evaluating extreme risks in ecology that rely on stochastic simulation, with a particular focus on methods to evaluate the likelihood of extinction and quasi-extinction of threatened species, and the likelihood of establishment and spread of invasive pests. We evaluate the importance of assumptions in these assessments and the potential of some new approaches to account for these uncertainties, including hierarchical estimation procedures and generalized extreme value distributions. We conclude by examining the treatment of consequences in extreme risk analysis in ecology and how expert judgment may better be harnessed to evaluate extreme risks.

  14. Feeling the extreme : an exploratory study of experienced emotions during extreme sport

    OpenAIRE

    Hetland, Audun

    2009-01-01

    In the current study 13 BASE-jumpers and 18 skydivers reported their emotions immediately after a jump and after a 24 hours delay, using verbal (Likert-like scales) and visual (Feelometer) emotional report. Heart rate measures were also collected during, and 24 hours after the jump. The Feelometer is a newly developed tool enabling the participants to give a moment-to-moment report from a particular event or episode. Given the complexity and dynamics of extreme sport experiences, the Feelomet...

  15. Feeling the extreme : an exploratory study of experienced emotions during extreme sport

    OpenAIRE

    Hetland, Audun

    2009-01-01

    In the current study 13 BASE-jumpers and 18 skydivers reported their emotions immediately after a jump and after a 24 hours delay, using verbal (Likert-like scales) and visual (Feelometer) emotional report. Heart rate measures were also collected during, and 24 hours after the jump. The Feelometer is a newly developed tool enabling the participants to give a moment-to-moment report from a particular event or episode. Given the complexity and dynamics of extreme sport experiences, the Feelomet...

  16. Microhabitats reduce animal's exposure to climate extremes.

    Science.gov (United States)

    Scheffers, Brett R; Edwards, David P; Diesmos, Arvin; Williams, Stephen E; Evans, Theodore A

    2014-02-01

    Extreme weather events, such as unusually hot or dry conditions, can cause death by exceeding physiological limits, and so cause loss of population. Survival will depend on whether or not susceptible organisms can find refuges that buffer extreme conditions. Microhabitats offer different microclimates to those found within the wider ecosystem, but do these microhabitats effectively buffer extreme climate events relative to the physiological requirements of the animals that frequent them? We collected temperature data from four common microhabitats (soil, tree holes, epiphytes, and vegetation) located from the ground to canopy in primary rainforests in the Philippines. Ambient temperatures were monitored from outside of each microhabitat and from the upper forest canopy, which represent our macrohabitat controls. We measured the critical thermal maxima (CTmax ) of frog and lizard species, which are thermally sensitive and inhabit our microhabitats. Microhabitats reduced mean temperature by 1-2 °C and reduced the duration of extreme temperature exposure by 14-31 times. Microhabitat temperatures were below the CTmax of inhabitant frogs and lizards, whereas macrohabitats consistently contained lethal temperatures. Microhabitat temperatures increased by 0.11-0.66 °C for every 1 °C increase in macrohabitat temperature, and this nonuniformity in temperature change influenced our forecasts of vulnerability for animal communities under climate change. Assuming uniform increases of 6 °C, microhabitats decreased the vulnerability of communities by up to 32-fold, whereas under nonuniform increases of 0.66 to 3.96 °C, microhabitats decreased the vulnerability of communities by up to 108-fold. Microhabitats have extraordinary potential to buffer climate and likely reduce mortality during extreme climate events. These results suggest that predicted changes in distribution due to mortality and habitat shifts that are derived from macroclimatic samples and that assume

  17. Anticipating Future Extreme Climate Events for Alaska Using Dynamical Downscaling and Quantile Mapping

    Science.gov (United States)

    Lader, R.; Walsh, J. E.

    2016-12-01

    Alaska is projected to experience major changes in extreme climate during the 21st century, due to greenhouse warming and exacerbated by polar amplification, wherein the Arctic is warming at twice the rate compared to the Northern Hemisphere. Given its complex topography, Alaska displays extreme gradients of temperature and precipitation. However, global climate models (GCMs), which typically have a spatial resolution on the order of 100km, struggle to replicate these extremes. To help resolve this issue, this study employs dynamically downscaled regional climate simulations and quantile-mapping methodologies to provide a full suite of daily model variables at 20 km spatial resolution for Alaska, from 1970 to 2100. These data include downscaled products of the: ERA-Interim reanalysis from 1979 to 2015, GFDL-CM3 historical from 1970 to 2005, and GFDL-CM3 RCP 8.5 from 2006 to 2100. Due to the limited nature of long-term observations and high-resolution modeling in Alaska, these data enable a broad expansion of extremes analysis. This study uses these data to highlight a subset of the 27 climate extremes indices, previously defined by the Expert Team on Climate Change Detection and Indices, as they pertain to climate change in Alaska. These indices are based on the statistical distributions of daily surface temperature and precipitation and focus on threshold exceedance, and percentiles. For example, the annual number of days with a daily maximum temperature greater than 25°C is anticipated to triple in many locations in Alaska by the end of the century. Climate extremes can also refer to long duration events, such as the record-setting warmth that defined the 2015-16 cold season in Alaska. The downscaled climate model simulations indicate that this past winter will be considered normal by as early as the mid-2040s, if we continue to warm according to the business-as-usual RCP 8.5 emissions scenario. This represents an accelerated warming as compared to projections

  18. NMR paramagnetic relaxation due to the S=5/2 complex, Fe(III)-(tetra-p-sulfonatophenyl)porphyrin: central role of the tetragonal fourth-order zero-field splitting interaction.

    Science.gov (United States)

    Schaefle, Nathaniel; Sharp, Robert

    2005-05-08

    The metalloporphyrins, Me-TSPP [Me=Cr(III), Mn(III), Mn(II), Fe(III), and TSPP=meso-(tetra-p-sulfonatophenyl)porphyrin], which possess electron spins S=3/2, 2, 5/2, and 5/2, respectively, comprise an important series of model systems for mechanistic studies of NMR paramagnetic relaxation enhancement (NMR-PRE). For these S>1/2 spin systems, the NMR-PRE depends critically on the detailed form of the zero-field splitting (zfs) tensor. We report the results of experimental and theoretical studies of the NMR relaxation mechanism associated with Fe(III)-TSPP, a spin 5/2 complex for which the overall zfs is relatively large (D approximately = 10 cm(-1)). A comparison of experimental data with spin dynamics simulations shows that the primary determinant of the shape of the magnetic relaxation dispersion profile of the water proton R1 is the tetragonal fourth-order component of the zfs tensor. The relaxation mechanism, which has not previously been described, is a consequence of zfs-induced mixing of the spin eigenfunctions of adjacent Kramers doublets. We have also investigated the magnetic-field dependence of electron-spin relaxation for S=5/2 in the presence of a large zfs, such as occurs in Fe(III)-TSPP. Calculations show that field dependence of this kind is suppressed in the vicinity of the zfs limit, in agreement with observation.

  19. Due process traditionalism.

    Science.gov (United States)

    Sunstein, Cass R

    2008-06-01

    In important cases, the Supreme Court has limited the scope of "substantive due process" by reference to tradition, but it has yet to explain why it has done so. Due process traditionalism might be defended in several distinctive ways. The most ambitious defense draws on a set of ideas associated with Edmund Burke and Friedrich Hayek, who suggested that traditions have special credentials by virtue of their acceptance by many minds. But this defense runs into three problems. Those who have participated in a tradition may not have accepted any relevant proposition; they might suffer from a systematic bias; and they might have joined a cascade. An alternative defense sees due process traditionalism as a second-best substitute for two preferable alternatives: a purely procedural approach to the Due Process Clause, and an approach that gives legislatures the benefit of every reasonable doubt. But it is not clear that in these domains, the first-best approaches are especially attractive; and even if they are, the second-best may be an unacceptably crude substitute. The most plausible defense of due process traditionalism operates on rule-consequentialist grounds, with the suggestion that even if traditions are not great, they are often good, and judges do best if they defer to traditions rather than attempting to specify the content of "liberty" on their own. But the rule-consequentialist defense depends on controversial and probably false assumptions about the likely goodness of traditions and the institutional incapacities of judges.

  20. In-Situ Micromechanical Testing in Extreme Environments

    Science.gov (United States)

    Lupinacci, Amanda Sofia

    were also utilized to obtain better understanding of the deformation mechanisms in the presence of a preexisting defect, such as a crack. Similar twinning behavior is observed in the Sn96 alloy however, it was also found that grain boundaries and second phase intermetallics can act as sources for dislocation motion and generation. The observations and analysis in this thesis give novel insight into the deformation mechanisms of two materials in extreme environments. In the case of cryogenic testing we have demonstrated the preference for Sn based solders to undergo deformation twinning as a primary deformation mechanism below the DBTT of the alloy. Prior to this study, deformation mechanisms of pure Sn below the DBTT were not well characterized due to a lack of experimental methods for doing so. In this study, we have developed a novel in situ cryogenic apparatus that has made it possible to systematically study plasticity mechanisms down to -142 °C. Through EBSD and TEM characterization of the twinning behavior at cryogenic temperatures, we have gained a greater understanding of the deformation mechanisms that are active below the DBTT. Furthermore, we have extended this technique to a more complex alloy, Sn96 as well as more complex geometries (clamped beam geometry). In the case of ion irradiated stainless steel, which is a surrogate for neutron irradiations, we have correlated the mechanical property response that is associated with various irradiation conditions with the defects induced during irradiation. Due to the fact that ion beam irradaion has a limted penetration depth, nanoindetation and micro compression testing needed to be deployed. Through both nanoindentation and Laue micro diffraction we have shown a direct correlation between the observed radaition induced increase in hardness and the radaition induced increase in FWHM. We found that 10dpa ion beam irradaion is enough to saturate the material in hardening as well as lattice strain which is related

  1. Tardigrades living in extreme environments have naturally selected prerequisites useful to space conquer

    Science.gov (United States)

    Guidetti, Roberto; Tiziana, Altiero; Cesari, Michele; Rizzo, Angela Maria; Bertolani, Roberto; Galletta, Giuseppe; Dalessandro, Maurizio; Rebecchi, Lorena

    Extreme habitats are highly selective and can host only living organisms possessing specific adaptations to stressors. Among extreme habitats, space environment has particular charac-teristics of radiations, vacuum, microgravity and temperature, which induce rapid changes in living systems. Consequently, the response of multicellular complex organisms, able to colo-nize extreme environments, to space stresses can give very useful information on the ability to withstand a single stress or stress combinations. This knowledge on changes in living systems in space, with their similarity to the ageing processes, offers the opportunity to improve human life both on Earth and in space. Even though experimentation in space has often been carried out using unicellular organisms, multicellular organisms are very relevant in order to develop the appropriate countermeasures to avoid the risks imposed by environmental space in humans. The little attention received by multicellular organisms is probably due, other than to difficul-ties in the manipulation of biological materials in space, to the presence of only few organisms with the potential to tolerate environmental space stresses. Among them, tardigrades are small invertebrates representing an attractive animal model to study adaptive strategies for surviving extreme environments, including space environment. Tardigrades are little known microscopic aquatic animals (250-800 m in body length) distributed in different environments (from the deep sea to high mountains and deserts all over the world), and frequently inhabiting very unstable and unpredictable habitats (e.g. interstices of mosses, lichens, leaf litter, freshwater ponds, cryoconite holes). Their ability to live in the extreme environments is related to a wide variety of their life histories and adaptive strategies. A widespread and crucial strategy is cryptobiosis, a form of quiescence. It includes strategies such as anhydrobiosis and cryobiosis, characterized by

  2. Spatial dependence of extreme rainfall

    Science.gov (United States)

    Radi, Noor Fadhilah Ahmad; Zakaria, Roslinazairimah; Satari, Siti Zanariah; Azman, Muhammad Az-zuhri

    2017-05-01

    This study aims to model the spatial extreme daily rainfall process using the max-stable model. The max-stable model is used to capture the dependence structure of spatial properties of extreme rainfall. Three models from max-stable are considered namely Smith, Schlather and Brown-Resnick models. The methods are applied on 12 selected rainfall stations in Kelantan, Malaysia. Most of the extreme rainfall data occur during wet season from October to December of 1971 to 2012. This period is chosen to assure the available data is enough to satisfy the assumption of stationarity. The dependence parameters including the range and smoothness, are estimated using composite likelihood approach. Then, the bootstrap approach is applied to generate synthetic extreme rainfall data for all models using the estimated dependence parameters. The goodness of fit between the observed extreme rainfall and the synthetic data is assessed using the composite likelihood information criterion (CLIC). Results show that Schlather model is the best followed by Brown-Resnick and Smith models based on the smallest CLIC's value. Thus, the max-stable model is suitable to be used to model extreme rainfall in Kelantan. The study on spatial dependence in extreme rainfall modelling is important to reduce the uncertainties of the point estimates for the tail index. If the spatial dependency is estimated individually, the uncertainties will be large. Furthermore, in the case of joint return level is of interest, taking into accounts the spatial dependence properties will improve the estimation process.

  3. Defining Political Extremism in the Balkans. The Case of Serbia

    Directory of Open Access Journals (Sweden)

    Babić Marko

    2015-12-01

    Full Text Available Political extremism (and particularly right wing political extremism remains relatively insufficiently explored due to the fact that the phenomenon is controversial and hard to define. Its ambiguity and variability depending on time and spatial point of view further complicates its definition. Its structure is amorphous and eclectic as it often includes elements from different ideologies and connects incompatible ideas. A multidimensional conceptualization and an interdisciplinary approach - sociological, social, psychological and historical, are the Author’s tools in explaining the phenomenon of political extremism in Serbia, hopefully contributing to its clarification and laying a foundation for its further explanatory theoretical studies.

  4. Onycholysis due to trauma

    Directory of Open Access Journals (Sweden)

    Patricia Chang

    2014-04-01

    Full Text Available Female patient, 35 years old who came to the private office due to discoloration of her left thumbnail and little pain since 1 month ago. Clinical examination shows nail disease on her left thumbnail with onycholysis and dyschromia, dermatoscopy showed white-yellowish discoloration (Fig. 1A, B. The rest of the clinical examination was normal. Patient use to using acrylic nails since 2 years ago and denied some trauma at the nail. The diagnosis of onycholysis due to trauma was done and recommended her not to use acrylic nail, maintain the nail short and avoid wetness.

  5. Extreme Thrombocytosis and Cardiovascular Surgery

    Science.gov (United States)

    Natelson, Ethan A.

    2012-01-01

    Extreme thrombocytosis is a major risk factor for excessive bleeding and for thrombosis, either of which can complicate cardiovascular surgical and interventional procedures. Extreme thrombocytosis can also cause an unusual syndrome, erythromelalgia, that results in a type of chronic microvascular occlusive arterial disease. We present the differential diagnosis of conditions that may lead to extreme thrombocytosis, 3 cases (each of which illustrates a different potential complication), and a review of the pertinent medical literature. Correcting excessive thrombocytosis is typically not difficult, whether electively or acutely, and effective therapy usually controls thrombosis and excessive hemorrhage postprocedurally. PMID:23304015

  6. Enabling Structured Exploration of Workflow Performance Variability in Extreme-Scale Environments

    Energy Technology Data Exchange (ETDEWEB)

    Kleese van Dam, Kerstin; Stephan, Eric G.; Raju, Bibi; Altintas, Ilkay; Elsethagen, Todd O.; Krishnamoorthy, Sriram

    2015-11-15

    Workflows are taking an Workflows are taking an increasingly important role in orchestrating complex scientific processes in extreme scale and highly heterogeneous environments. However, to date we cannot reliably predict, understand, and optimize workflow performance. Sources of performance variability and in particular the interdependencies of workflow design, execution environment and system architecture are not well understood. While there is a rich portfolio of tools for performance analysis, modeling and prediction for single applications in homogenous computing environments, these are not applicable to workflows, due to the number and heterogeneity of the involved workflow and system components and their strong interdependencies. In this paper, we investigate workflow performance goals and identify factors that could have a relevant impact. Based on our analysis, we propose a new workflow performance provenance ontology, the Open Provenance Model-based WorkFlow Performance Provenance, or OPM-WFPP, that will enable the empirical study of workflow performance characteristics and variability including complex source attribution.

  7. Technical Due Diligence

    DEFF Research Database (Denmark)

    Jensen, Per Anker; Varano, Mattia

    2011-01-01

    Technical Due Diligence (TDD) as an evaluation of the performance of constructed facilities has become an important new field of practice for consultants. Before the financial crisis started in autumn 2008 it represented the fastest growing activity in some consulting companies. TDD is mostly car...

  8. Extremely secure identification documents

    Energy Technology Data Exchange (ETDEWEB)

    Tolk, K.M. [Sandia National Labs., Albuquerque, NM (United States); Bell, M. [Sandia National Labs., Livermore, CA (United States)

    1997-09-01

    The technology developed in this project uses biometric information printed on the document and public key cryptography to ensure that an adversary cannot issue identification documents to unauthorized individuals or alter existing documents to allow their use by unauthorized individuals. This process can be used to produce many types of identification documents with much higher security than any currently in use. The system is demonstrated using a security badge as an example. This project focused on the technologies requiring development in order to make the approach viable with existing badge printing and laminating technologies. By far the most difficult was the image processing required to verify that the picture on the badge had not been altered. Another area that required considerable work was the high density printed data storage required to get sufficient data on the badge for verification of the picture. The image processing process was successfully tested, and recommendations are included to refine the badge system to ensure high reliability. A two dimensional data array suitable for printing the required data on the badge was proposed, but testing of the readability of the array had to be abandoned due to reallocation of the budgeted funds by the LDRD office.

  9. A method to characterize the different extreme waves for islands exposed to various wave regimes: a case study devoted to Reunion Island

    Directory of Open Access Journals (Sweden)

    S. Lecacheux

    2012-07-01

    Full Text Available This paper outlines a new approach devoted to the analysis of extreme waves in presence of several wave regimes. It entails discriminating the different wave regimes from offshore wave data using classification algorithms, before conducting the extreme wave analysis for each regime separately. The concept is applied to the pilot site of Reunion Island which is affected by three main wave regimes: southern waves, trade-wind waves and cyclonic waves. Several extreme wave scenarios are determined for each regime, based on real historical cases (for cyclonic waves and extreme value analysis (for non-cyclonic waves. For each scenario, the nearshore wave characteristics are modelled all around Reunion Island and the linear theory equations are used to back calculate the equivalent deep-water wave characteristics for each portion of the coast. The relative exposure of the coastline to the extreme waves of each regime is determined by comparing the equivalent deep-water wave characteristics.

    This method provides a practical framework to perform an analysis of extremes within a complex environment presenting several sources of extreme waves. First, at a particular coastal location, it allows for inter-comparison between various kinds of extreme waves that are generated by different processes and that may occur at different periods of the year. Then, it enables us to analyse the alongshore variability in wave exposition, which is a good indicator of potential runup extreme values. For the case of Reunion Island, cyclonic waves are dominant offshore around the island, with equivalent deep-water wave heights up to 18 m for the northern part. Nevertheless, due to nearshore wave refraction, southern waves may become as energetic as cyclonic waves on the western part of the island and induce similar impacts in terms of runup and submersion. This method can be easily transposed to other case studies and can be adapted, depending on the data

  10. Traumatic extremity arterial injury in children: Epidemiology, diagnostics, treatment and prognostic value of Mangled Extremity Severity Score

    OpenAIRE

    Lange Nadine; Khaladj Nawid; Frink Michael; Hildebrand Frank; Zeckey Christian; Mommsen Philipp; Krettek Christian; Probst Christian

    2010-01-01

    Abstract Background Traumatic paediatric arterial injuries are a great challenge due to low incidence and specific characteristics of paediatric anatomy and physiology. The aim of the present study was to investigate their epidemiology, diagnostic and therapeutic options and complications. Furthermore, the prognostic value of the Mangled Extremity Severity Score (MESS) was evaluated. Methods In a retrospective clinical study 44 children aged 9.0 ± 3.2 years treated for traumatic extremity art...

  11. Extreme hypertriglyceridemia managed with insulin.

    Science.gov (United States)

    Thuzar, Moe; Shenoy, Vasant V; Malabu, Usman H; Schrale, Ryan; Sangla, Kunwarjit S

    2014-01-01

    Extreme hypertriglyceridemia can lead to acute pancreatitis and rapid lowering of serum triglycerides (TG) is necessary for preventing such life-threatening complications. However, there is no established consensus on the acute management of extreme hypertriglyceridemia. We retrospectively reviewed 10 cases of extreme hypertriglyceridemia with mean serum TG on presentation of 101.5 ± 23.4 mmol/L (8982 ± 2070 mg/dL) managed with insulin. Serum TG decreased by 87 ± 4% in 24 hours in those patients managed with intravenous insulin and fasting and 40 ± 8.4% in those managed with intravenous insulin alone (P = .0003). The clinical course was uncomplicated in all except 1 patient who subsequently developed a pancreatic pseudocyst. Thus, combination of intravenous insulin with fasting appears to be an effective, simple, and safe treatment strategy in immediate management of extreme hypertriglyceridemia. Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.

  12. Moment methods in extremal geometry

    NARCIS (Netherlands)

    De Laat, D.

    2016-01-01

    In this thesis we develop techniques for solving problems in extremal geometry. We give an infinite dimensional generalization of moment techniques from polynomial optimization. We use this to construct semidefinite programming hierarchies for approximating optimal packing densities and ground state

  13. Moment methods in extremal geometry

    NARCIS (Netherlands)

    De Laat, D.

    2016-01-01

    In this thesis we develop techniques for solving problems in extremal geometry. We give an infinite dimensional generalization of moment techniques from polynomial optimization. We use this to construct semidefinite programming hierarchies for approximating optimal packing densities and ground state

  14. Statistical Model of Extreme Shear

    DEFF Research Database (Denmark)

    Larsen, Gunner Chr.; Hansen, Kurt Schaldemose

    2004-01-01

    In order to continue cost-optimisation of modern large wind turbines, it is important to continously increase the knowledge on wind field parameters relevant to design loads. This paper presents a general statistical model that offers site-specific prediction of the probability density function...... by a model that, on a statistically consistent basis, describe the most likely spatial shape of an extreme wind shear event. Predictions from the model have been compared with results from an extreme value data analysis, based on a large number of high-sampled full-scale time series measurements...... are consistent, given the inevitabel uncertainties associated with model as well as with the extreme value data analysis. Keywords: Statistical model, extreme wind conditions, statistical analysis, turbulence, wind loading, statistical analysis, turbulence, wind loading, wind shear, wind turbines....

  15. Predictability of extremes in non-linear hierarchically organized systems

    Science.gov (United States)

    Kossobokov, V. G.; Soloviev, A.

    2011-12-01

    Understanding the complexity of non-linear dynamics of hierarchically organized systems progresses to new approaches in assessing hazard and risk of the extreme catastrophic events. In particular, a series of interrelated step-by-step studies of seismic process along with its non-stationary though self-organized behaviors, has led already to reproducible intermediate-term middle-range earthquake forecast/prediction technique that has passed control in forward real-time applications during the last two decades. The observed seismic dynamics prior to and after many mega, great, major, and strong earthquakes demonstrate common features of predictability and diverse behavior in course durable phase transitions in complex hierarchical non-linear system of blocks-and-faults of the Earth lithosphere. The confirmed fractal nature of earthquakes and their distribution in space and time implies that many traditional estimations of seismic hazard (from term-less to short-term ones) are usually based on erroneous assumptions of easy tractable analytical models, which leads to widespread practice of their deceptive application. The consequences of underestimation of seismic hazard propagate non-linearly into inflicted underestimation of risk and, eventually, into unexpected societal losses due to earthquakes and associated phenomena (i.e., collapse of buildings, landslides, tsunamis, liquefaction, etc.). The studies aimed at forecast/prediction of extreme events (interpreted as critical transitions) in geophysical and socio-economical systems include: (i) large earthquakes in geophysical systems of the lithosphere blocks-and-faults, (ii) starts and ends of economic recessions, (iii) episodes of a sharp increase in the unemployment rate, (iv) surge of the homicides in socio-economic systems. These studies are based on a heuristic search of phenomena preceding critical transitions and application of methodologies of pattern recognition of infrequent events. Any study of rare

  16. 38 CFR 4.58 - Arthritis due to strain.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Arthritis due to strain... FOR RATING DISABILITIES Disability Ratings The Musculoskeletal System § 4.58 Arthritis due to strain. With service incurred lower extremity amputation or shortening, a disabling arthritis, developing in...

  17. Large Extremity Peripheral Nerve Repair

    Science.gov (United States)

    2015-10-01

    IL, Kochevar IE, Redmond RW. Large extremity peripheral nerve repair. Military Health System Research Symposium (MHSRS) Fort Lauderdale, FL. August...some notable discoveries that may impact military health care in the near future. There is a clear need in military medicine to improve outcomes in...membranes or “caul” intact was considered extremely lucky. Children were gifted with life-long happiness , the ability to see spirits, and protection

  18. Observed Statistics of Extreme Waves

    Science.gov (United States)

    2006-12-01

    9 Figure 5. An energy stealing wave as a solution to the NLS equation . (From: Dysthe and...shown that nonlinear interaction between four colliding waves can produce extreme wave behavior. He utilized the NLS equation in his numerical ...2000) demonstrated the formation of extreme waves using the Korteweg de Vries ( KdV ) equation , which is valid in shallow water. It was shown in the

  19. Weather Extremes Around the World

    Science.gov (United States)

    1974-04-01

    or ever has occurred. According to M. A. Arkin, "... record extremes must be taken with a grain of salt .... Ř He explains that news of an extreme...the edge of the Danakil Depression, a salt desert. By averaging the annual mean daily maximum temperature of 106°F36 atid the annual mean daily...increased by orographic lifting.1" Asa result of these monsoon disturbances, which are still not fully understood, the eastern Himalayan 105 106

  20. Irrigation mitigates against heat extremes

    Science.gov (United States)

    Thiery, Wim; Fischer, Erich; Visser, Auke; Hirsch, Annette L.; Davin, Edouard L.; Lawrence, Dave; Hauser, Mathias; Seneviratne, Sonia I.

    2017-04-01

    Irrigation is an essential practice for sustaining global food production and many regional economies. Emerging scientific evidence indicates that irrigation substantially affects mean climate conditions in different regions of the world. Yet how this practice influences climate extremes is currently unknown. Here we use gridded observations and ensemble simulations with the Community Earth System Model to assess the impacts of irrigation on climate extremes. While the influence of irrigation on annual mean temperatures is limited, we find a large impact on temperature extremes, with a particularly strong cooling during the hottest day of the year (-0.78 K averaged over irrigated land). The strong influence on hot extremes stems from the timing of irrigation and its influence on land-atmosphere coupling strength. Together these effects result in asymmetric temperature responses, with a more pronounced cooling during hot and/or dry periods. The influence of irrigation is even more pronounced when considering subgrid-scale model output, suggesting that local effects of land management are far more important than previously thought. Finally we find that present-day irrigation is partly masking GHG-induced warming of extreme temperatures, with particularly strong effects in South Asia. Our results overall underline that irrigation substantially reduces our exposure to hot temperature extremes and highlight the need to account for irrigation in future climate projections.

  1. Complications of extremity vascular injuries in conflict.

    Science.gov (United States)

    Brown, Kate V; Ramasamy, Arul; Tai, Nigel; MacLeod, Judith; Midwinter, Mark; Clasper, Jon C

    2009-04-01

    The extremities remain the most common sites of wounding in conflict, are associated with a significant incidence of vascular trauma, and have a high complication rate (infection, secondary amputation, and graft thrombosis). The purpose of this study was to study the complication rate after extremity vascular injury. In particular, the aim was to analyze whether this was influenced by the presence or absence of a bony injury. A prospectively maintained trauma registry was retrospectively reviewed for all UK military casualties with extremity injuries (Abbreviated Injury Score >1) December 8, 2003 to May 12, 2008. Demographics and the details of their vascular injuries, management, and outcome were documented using the trauma audit and medical notes. Thirty-four patients (34%)--37 limbs (30%)--had sustained a total of 38 vascular injuries. Twenty-eight limbs (22.6%) had an associated fracture, 9 (7.3%) did not. Twenty-nine limbs (23.4%) required immediate revascularization to preserve their limb: 16 limbs (13%) underwent an initial Damage Control procedure, and 13 limbs (10.5%) underwent Definitive Surgery. Overall, there were 25 limbs (20.2%) with complications. Twenty-two were in the 28 limbs with open fractures, 3 were in the 9 limbs without a fracture (p vascular trauma if there is an associated fracture, probably due to higher energy transfer and greater tissue damage.

  2. Overview of extremity arterial trauma in Jordan.

    Science.gov (United States)

    Heis, H A; Bani-Hani, K E; Elheis, M A

    2008-12-01

    The objectives of this study were to review etiologies of trauma, associated injuries, diagnosis, management, and outcomes of patients with vascular injuries in the extremities and relate factors in their treatment to the outcome of the injured extremity. Data were collected retrospectively on 73 patients diagnosed to have upper and lower limbs arterial injuries at King Abdullah University Hospital, Jordan, between 2001 and 2006. Factors evaluated included demographic data, location of vessels injured, mechanism of injury, associated injuries, treatment, and outcome. Patients were predominantly males (54 patients). Isolated vascular trauma was present in 36 patients, while in the remaining 37 patients vascular trauma was aggravated by concomitant injuries. The most common etiology of vascular injuries in the upper and lower extremities was a penetrating injury found in 38 patients (52%). The vessels most commonly involved were the femoral and brachial arteries. Various associated injuries were identified mainly orthopedic in 21 patients (29%) and nerve injuries in 18 patients (25%). Autogenous vein graft interposition was mostly performed in 32 patients (44%). Permanent disability was seen in 8 patients (11%), limb amputation was performed in 5 patients (7%). Five patients died due to associated intraabdominal, thoracic, and head injuries giving a mortality rate of 7%. Delay in surgery, blunt trauma and extensive soft tissue defect in combined orthopedic and vascular injuries were associated with increased risk of amputation, while associated nerve injuries and bone injuries with extensive soft tissue damage are risk factors of poor quality outcome.

  3. Nonstationary modeling of extreme precipitation in China

    Science.gov (United States)

    Gao, Meng; Mo, Dingyuan; Wu, Xiaoqing

    2016-12-01

    The statistical methods based on extreme value theory have been traditionally used in meteorology and hydrology for a long time. Due to climate change and variability, the hypothesis of stationarity in meteorological or hydrological time series was usually not satisfied. In this paper, a nonstationary extreme value analysis was conducted for annual maximum daily precipitation (AMP) at 631 meteorological stations over China for the period 1951-2013. Stationarity of all 631 AMP time series was firstly tested using KPSS test method, and only 48 AMP time series showed non-stationarity at 5% significance level. The trends of these 48 nonstationary AMP time series were further tested using M-K test method. There were 25 nonstationary AMP time series mainly distributed in southern and western China showing significant positive trend at 5% level. Another 5 nonstationary AMP time series with significant negative trends were near northern urban agglomeration, Sichuan Basin, and central China. For these nonstationary AMP time series with significant positive or negative trends, the location parameter in generalized extreme value (GEV) distribution was assumed to be time-varying, and the trends were successfully characterized by the nonstationary GEV models. For the remaining 18 nonstationary AMP time series mainly in the eastern portion of China, no significant trend was detected. The correlation analysis showed that only 5 nonstationary AMP time series were significantly correlated with one or two of the four climate indices EASMI, WPI, SOI, and PDO. Then, the location and scale parameters in the GEV distribution were modeled as functions of the significantly correlated climate indices. The modeling results in this study showed that the nonstationary GEV distributions performed better than their stationary equivalents. Finally, 20-year and 50-year return levels of precipitation extremes at all 631 stations were estimated using the best fitting distribution for the year 1961

  4. A comparative assessment of statistical methods for extreme weather analysis

    Science.gov (United States)

    Schlögl, Matthias; Laaha, Gregor

    2017-04-01

    Extreme weather exposure assessment is of major importance for scientists and practitioners alike. We compare different extreme value approaches and fitting methods with respect to their value for assessing extreme precipitation and temperature impacts. Based on an Austrian data set from 25 meteorological stations representing diverse meteorological conditions, we assess the added value of partial duration series over the standardly used annual maxima series in order to give recommendations for performing extreme value statistics of meteorological hazards. Results show the merits of the robust L-moment estimation, which yielded better results than maximum likelihood estimation in 62 % of all cases. At the same time, results question the general assumption of the threshold excess approach (employing partial duration series, PDS) being superior to the block maxima approach (employing annual maxima series, AMS) due to information gain. For low return periods (non-extreme events) the PDS approach tends to overestimate return levels as compared to the AMS approach, whereas an opposite behavior was found for high return levels (extreme events). In extreme cases, an inappropriate threshold was shown to lead to considerable biases that may outperform the possible gain of information from including additional extreme events by far. This effect was neither visible from the square-root criterion, nor from standardly used graphical diagnosis (mean residual life plot), but from a direct comparison of AMS and PDS in synoptic quantile plots. We therefore recommend performing AMS and PDS approaches simultaneously in order to select the best suited approach. This will make the analyses more robust, in cases where threshold selection and dependency introduces biases to the PDS approach, but also in cases where the AMS contains non-extreme events that may introduce similar biases. For assessing the performance of extreme events we recommend conditional performance measures that focus

  5. Increase of record-breaking temperature and precipitation extremes in a warming world

    Science.gov (United States)

    Coumou, D.; Lehmann, J.; Robinson, A.; Rahmstorf, S.

    2011-12-01

    The last decade has seen many record-breaking weather events, including severe heat waves, as well as rainfall and drought extremes. At the same time, this decade was globally the warmest since accurate measurements started in the 19th century. This raises the question, often asked by public and media directly after the occurrence of a specific extreme, whether these extremes are related to global warming. Here we analyze record-breaking events in the last decade using global gridded datasets of monthly-mean surface temperature and precipitation. We compare the number of observed records with those expected in a stationary climate, for which the simple 1/n relationship holds, with n the number of previous data points (e.g. years). In addition, we develop a first-order theoretical model to quantify the respective contributions of climate change and natural variability to the occurrence of records. World wide the number of monthly heat records is now, on average 5 times larger than expected in a stationary climate. This indicates that record-breaking heat waves lasting for several weeks now have, on average, an 80% chance of being due to climatic warming. Some tropical regions including East-Africa, India and Amazonia have seen an even larger increase in the number of record breaking events, pushing the probability that a record event is due to climatic warming to more than 90%. The high number of observed records is well explained by a model assuming a linear warming over the last 40 years. Precipitation extremes are more complex than heat extremes as different physical processes associated with global warming are likely to affect them. Warmer air can hold more moisture and thus, in principle, enhances extremes in both rainfall maxima and minima. Also, changes in wind patterns will affect precipitation and it is expected that dry areas will become drier and wet areas wetter. We show that, globally averaged the number of observed records, both for minima and maxima

  6. Assessing Climate Variability using Extreme Rainfall and ...

    African Journals Online (AJOL)

    user1

    As noted by the Bureau of Meteorology, Canada, to examine whether such ... their local climate, a threshold considered extreme in one part of Australia could be ... (extreme frequency); the average intensity of rainfall from extreme events.

  7. Are hourly precipitation extremes increasing faster than daily precipitation extremes?

    Science.gov (United States)

    Barbero, Renaud; Fowler, Hayley; Blenkinsop, Stephen; Lenderink, Geert

    2016-04-01

    Extreme precipitation events appear to be increasing with climate change in many regions of the world, including the United States. These extreme events have large societal impacts, as seen during the recent Texas-Oklahoma flooding in May 2015 which caused several billion in damages and left 47 deaths in its path. Better understanding of past changes in the characteristics of extreme rainfall events is thus critical for reliable projections of future changes. Although it has been documented in several studies that daily precipitation extremes are increasing across parts of the contiguous United States, very few studies have looked at hourly extremes. However, this is of primary importance as recent studies on the temperature scaling of extreme precipitation have shown that increases above the Clausius-Clapeyron (~ 7% °C-1) are possible for hourly precipitation. In this study, we used hourly precipitation data (HPD) from the National Climatic Data Center and extracted more than 1,000 stations across the US with more than 40 years of data spanning the period 1950-2010. As hourly measurements are often associated with a range of issues, the data underwent multiple quality control processes to exclude erroneous data. While no significant changes were found in annual maximum precipitation using both hourly and daily resolution datasets, significant increasing trends in terms of frequency of episodes exceeding present-day 95th percentiles of wet hourly/daily precipitation were observed across a significant portion of the US. The fraction of stations with significant increasing trends falls outside the confidence interval range during all seasons but the summer. While less than 12% of stations exhibit significant trends at the daily scale in the wintertime, more than 45% of stations, mostly clustered in central and Northern United States, show significant increasing trends at the hourly scale. This suggests that short-duration storms have increased faster than daily

  8. Regional trends in short-duration precipitation extremes: a flexible multivariate monotone quantile regression approach

    Science.gov (United States)

    Cannon, Alex

    2017-04-01

    Estimating historical trends in short-duration rainfall extremes at regional and local scales is challenging due to low signal-to-noise ratios and the limited availability of homogenized observational data. In addition to being of scientific interest, trends in rainfall extremes are of practical importance, as their presence calls into question the stationarity assumptions that underpin traditional engineering and infrastructure design practice. Even with these fundamental challenges, increasingly complex questions are being asked about time series of extremes. For instance, users may not only want to know whether or not rainfall extremes have changed over time, they may also want information on the modulation of trends by large-scale climate modes or on the nonstationarity of trends (e.g., identifying hiatus periods or periods of accelerating positive trends). Efforts have thus been devoted to the development and application of more robust and powerful statistical estimators for regional and local scale trends. While a standard nonparametric method like the regional Mann-Kendall test, which tests for the presence of monotonic trends (i.e., strictly non-decreasing or non-increasing changes), makes fewer assumptions than parametric methods and pools information from stations within a region, it is not designed to visualize detected trends, include information from covariates, or answer questions about the rate of change in trends. As a remedy, monotone quantile regression (MQR) has been developed as a nonparametric alternative that can be used to estimate a common monotonic trend in extremes at multiple stations. Quantile regression makes efficient use of data by directly estimating conditional quantiles based on information from all rainfall data in a region, i.e., without having to precompute the sample quantiles. The MQR method is also flexible and can be used to visualize and analyze the nonlinearity of the detected trend. However, it is fundamentally a

  9. PRACE resources to study extreme natural events: the SCENE project

    Science.gov (United States)

    Fiori, Elisabetta; Galizia, Antonella; Danovaro, Emanuele; Clematis, Andrea; Bedrina, Tatiana; Parodi, Antonio

    2014-05-01

    Forecasting severe storms and floods is one of the main challenges of 21th century. Floods are the most dangerous meteorological hazard in the Mediterranean basins due to both the number of people affected and to the relatively high frequency by which human activities and goods suffer damages and losses. The numerical simulations of extreme events which happen over small basins as the Mediterranean ones are need a very fine-resolution in space and time and as a consequence considerable memory and computational power are required. Since the resources provided by the PRACE project represent the solution for satisfying such requirements, the Super Computing of Extreme Natural Events (SCENE) project has been proposed. SCENE aims to provide an advanced understanding of the intrinsic predictability of severe precipitation processes and the associated predictive ability of high-resolution meteorological models with a special focus on flash flood-producing storms in regions of complex orography (e.g. Mediterranean area) through the assessment of the role of both the convective and microphysical processes. The meteorological model considered in the project is the Weather Research and Forecasting (WRF) model, a state of the art mesoscale numerical weather prediction system designed to serve both operational forecasting and atmospheric research needs. Thus, among all the parameterizations available in the WRF model, the WRF Single-Moment 6-Class Scheme and the Thompson microphysics scheme will be adopted for the numerical simulations in combination with three different approaches for the treatment of the convective processes, that is the use of explicit method, Betts-Miller-Janjic Scheme and Kain-Fritsch. As for flash-flood producing storms, the project considers the recent sequence of extreme events occurred in the north-western portion of the Mediterranean sea; some of these events are the so-called critical cases of the DRIHM project (www.drihm.eu), i.e. selected severe

  10. Rising Precipitation Extremes across Nepal

    Directory of Open Access Journals (Sweden)

    Ramchandra Karki

    2017-01-01

    Full Text Available As a mountainous country, Nepal is most susceptible to precipitation extremes and related hazards, including severe floods, landslides and droughts that cause huge losses of life and property, impact the Himalayan environment, and hinder the socioeconomic development of the country. Given that the countrywide assessment of such extremes is still lacking, we present a comprehensive picture of prevailing precipitation extremes observed across Nepal. First, we present the spatial distribution of daily extreme precipitation indices as defined by the Expert Team on Climate Change Detection, Monitoring and Indices (ETCCDMI from 210 stations over the period of 1981–2010. Then, we analyze the temporal changes in the computed extremes from 76 stations, featuring long-term continuous records for the period of 1970–2012, by applying a non-parametric Mann−Kendall test to identify the existence of a trend and Sen’s slope method to calculate the true magnitude of this trend. Further, the local trends in precipitation extremes have been tested for their field significance over the distinct physio-geographical regions of Nepal, such as the lowlands, middle mountains and hills and high mountains in the west (WL, WM and WH, respectively, and likewise, in central (CL, CM and CH and eastern (EL, EM and EH Nepal. Our results suggest that the spatial patterns of high-intensity precipitation extremes are quite different to that of annual or monsoonal precipitation. Lowlands (Terai and Siwaliks that feature relatively low precipitation and less wet days (rainy days are exposed to high-intensity precipitation extremes. Our trend analysis suggests that the pre-monsoonal precipitation is significantly increasing over the lowlands and CH, while monsoonal precipitation is increasing in WM and CH and decreasing in CM, CL and EL. On the other hand, post-monsoonal precipitation is significantly decreasing across all of Nepal while winter precipitation is decreasing

  11. Extreme events, intrinsic landforms and humankind: Post-tsunami scenario along Nagore–Velankanni coast, Tamil Nadu, India

    Digital Repository Service at National Institute of Oceanography (India)

    Mascarenhas, A.

    complexes act as physical barriers and protect the hinterland from the forces of the ocean, including wave run - up due to extreme events. Wide beaches and high dunes act as efficient dissipators of wave energy. Sand dunes serve as a store that waves... are demolished. c , Pr u dent restoration of a damaged coast: sand dunes are recreated, forests are extended, ro ads are redesigned, buildings are r e- located inland, port is shifted upstream, sea walls are avoided, adequate buffer zones are designated. a...

  12. Book review: Extreme ocean waves

    Science.gov (United States)

    Geist, Eric L.

    2017-01-01

    Extreme Ocean Waves”, edited by E. Pelinovsky and C. Kharif, second edition, Springer International Publishing, 2016; ISBN: 978-3-319-21574-7, ISBN (eBook): 978-3-319-21575-4The second edition of “Extreme Ocean Waves” published by Springer is an update of a collection of 12 papers edited by Efim Pelinovsky and Christian Kharif following the April 2007 meeting of the General Assembly of the European Geosciences Union. In this edition, three new papers have been added and three more have been substantially revised. Color figures are now included, which greatly aids in reading several of the papers, and is especially helpful in visualizing graphs as in the paper on symbolic computation of nonlinear wave resonance (Tobisch et al.). A note on terminology: extreme waves in this volume broadly encompass different types of waves, including deep-water and shallow-water rogue waves (which are alternatively termed freak waves), and internal waves. One new paper on tsunamis (Viroulet et al.) is now included in the second edition of this volume. Throughout the book, the reader will find a combination of laboratory, theoretical, and statistical/empirical treatment necessary for the complete examination of this subject. In the Introduction, the editors underscore the importance of studying extreme waves, documenting a dramatic instance of damaging extreme waves that recently occurred in 2014.

  13. Extreme lattices: symmetries and decorrelation

    Science.gov (United States)

    Andreanov, A.; Scardicchio, A.; Torquato, S.

    2016-11-01

    We study statistical and structural properties of extreme lattices, which are the local minima in the density landscape of lattice sphere packings in d-dimensional Euclidean space {{{R}}d} . Specifically, we ascertain statistics of the densities and kissing numbers as well as the numbers of distinct symmetries of the packings for dimensions 8 through 13 using the stochastic Voronoi algorithm. The extreme lattices in a fixed dimension of space d (d≥slant 8 ) are dominated by typical lattices that have similar packing properties, such as packing densities and kissing numbers, while the best and the worst packers are in the long tails of the distribution of the extreme lattices. We also study the validity of the recently proposed decorrelation principle, which has important implications for sphere packings in general. The degree to which extreme-lattice packings decorrelate as well as how decorrelation is related to the packing density and symmetry of the lattices as the space dimension increases is also investigated. We find that the extreme lattices decorrelate with increasing dimension, while the least symmetric lattices decorrelate faster.

  14. Influence of extreme weather disasters on global crop production.

    Science.gov (United States)

    Lesk, Corey; Rowhani, Pedram; Ramankutty, Navin

    2016-01-07

    In recent years, several extreme weather disasters have partially or completely damaged regional crop production. While detailed regional accounts of the effects of extreme weather disasters exist, the global scale effects of droughts, floods and extreme temperature on crop production are yet to be quantified. Here we estimate for the first time, to our knowledge, national cereal production losses across the globe resulting from reported extreme weather disasters during 1964-2007. We show that droughts and extreme heat significantly reduced national cereal production by 9-10%, whereas our analysis could not identify an effect from floods and extreme cold in the national data. Analysing the underlying processes, we find that production losses due to droughts were associated with a reduction in both harvested area and yields, whereas extreme heat mainly decreased cereal yields. Furthermore, the results highlight ~7% greater production damage from more recent droughts and 8-11% more damage in developed countries than in developing ones. Our findings may help to guide agricultural priorities in international disaster risk reduction and adaptation efforts.

  15. Future increases in extreme precipitation exceed observed scaling rates

    Science.gov (United States)

    Bao, Jiawei; Sherwood, Steven C.; Alexander, Lisa V.; Evans, Jason P.

    2017-01-01

    Models and physical reasoning predict that extreme precipitation will increase in a warmer climate due to increased atmospheric humidity. Observational tests using regression analysis have reported a puzzling variety of apparent scaling rates including strong rates in midlatitude locations but weak or negative rates in the tropics. Here we analyse daily extreme precipitation events in several Australian cities to show that temporary local cooling associated with extreme events and associated synoptic conditions reduces these apparent scaling rates, especially in warmer climatic conditions. A regional climate projection ensemble for Australia, which implicitly includes these effects, accurately and robustly reproduces the observed apparent scaling throughout the continent for daily precipitation extremes. Projections from the same model show future daily extremes increasing at rates faster than those inferred from observed scaling. The strongest extremes (99.9th percentile events) scale significantly faster than near-surface water vapour, between 5.7-15% °C-1 depending on model details. This scaling rate is highly correlated with the change in water vapour, implying a trade-off between a more arid future climate or one with strong increases in extreme precipitation. These conclusions are likely to generalize to other regions.

  16. Future Trends in Extreme Temperatures over the Western U.S.: The Influence of Terrain and Coastlines

    Science.gov (United States)

    Brewer, M.

    2015-12-01

    A number of studies have suggested that heat waves will increase in frequency, intensity, and duration under anthropogenic global warming. However, these trends are less understood in regions of complex terrain or in coastal regions where temperature gradients are relatively larger and mesoscale features are important. Thus it is important to understand the regional impacts of terrain and land/water contrasts on heat extremes in a warming world, and identify changes in the conditions that drive such extremes. The northwest U.S. is a region with such surface complexity, where regional heat extremes arise from synoptic/mesoscale interactions between the large-scale flow and local topography This talk will analyze changes to the synoptic and mesoscale conditions associated with heat extremes over the northwest U.S. by utilizing CMIP5 global climate model simulations, and dynamically downscaled regional climate models. An analysis of changes in mid- to low-level tropospheric temperature, offshore/onshore flow, soil moisture, precipitation, and cloud fraction are described, as well as how these changes interact with regional terrain and land/water contrasts to alter the temperature distributions over the region. CMIP5 models suggest that low-level zonal wind distributions over the northwest U.S. become narrower, leading to fewer days with strong offshore flow. Soil moisture is projected to decline over the region due to reductions in clouds and precipitation, as well as general warming. Historical and future regional temperature distributions will be described, and it will be shown that even though climate models predict increases in heat extremes for western Oregon and Washington, these increases are far fewer compared to inland areas. The variance over most inland locations increases, with the exception of the northwest U.S., where variance doesn't change. The importance of regional terrain and land/water contrasts in explaining these changes will be described.

  17. Credit where due.

    Science.gov (United States)

    Friedman, Steven G

    2016-08-01

    The history of medicine is filled with stories of tireless researchers who failed to get credit for their hard work. Examples of this include Rosalind Franklin, who helped to elucidate the structure of DNA; Frederick Banting, who helped to discover insulin; and Jay McLean, who discovered heparin. The founding of the field of vascular surgery provides one of the most vivid examples of uncredited work. Even though Alexis Carrel was an unpaid, untitled assistant in Charles Guthrie's laboratory, it was Carrel alone who received a Nobel Prize for their work. In an attempt to give credit where due, the reasons for this injustice are described. Copyright © 2016 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

  18. Streamflow response to increasing precipitation extremes altered by forest management

    Science.gov (United States)

    Kelly, Charlene N.; McGuire, Kevin J.; Miniat, Chelcy Ford; Vose, James M.

    2016-04-01

    Increases in extreme precipitation events of floods and droughts are expected to occur worldwide. The increase in extreme events will result in changes in streamflow that are expected to affect water availability for human consumption and aquatic ecosystem function. We present an analysis that may greatly improve current streamflow models by quantifying the impact of the interaction between forest management and precipitation. We use daily long-term data from paired watersheds that have undergone forest harvest or species conversion. We find that interactive effects of climate change, represented by changes in observed precipitation trends, and forest management regime, significantly alter expected streamflow most often during extreme events, ranging from a decrease of 59% to an increase of 40% in streamflow, depending upon management. Our results suggest that vegetation might be managed to compensate for hydrologic responses due to climate change to help mitigate effects of extreme changes in precipitation.

  19. Simulating transitional hydrodynamics of the cerebrospinal fluid at extreme scale

    Science.gov (United States)

    Jain, Kartik; Roller, Sabine; Mardal, Kent-Andre

    Chiari malformation type I is a disorder characterized by the herniation of cerebellar tonsils into the spinal canal through the foramen magnum resulting in obstruction to cerebrospinal fluid (CSF) outflow. The flow of pulsating bidirectional CSF is of acutely complex nature due to the anatomy of the conduit containing it - the subarachnoid space. We report lattice Boltzmann method based direct numerical simulations on patient specific cases with spatial resolution of 24 μm amounting meshes of up to 2 billion cells conducted on 50000 cores of the Hazelhen supercomputer in Stuttgart. The goal is to characterize intricate dynamics of the CSF at resolutions that are of the order of Kolmogorov microscales. Results unfold velocity fluctuations up to ~ 10 KHz , turbulent kinetic energy ~ 2 times of the mean flow energy in Chiari patients whereas the flow remains laminar in a control subject. The fluctuations confine near the cranio-vertebral junction and are commensurate with the extremeness of pathology and the extent of herniation. The results advocate that the manifestation of pathological conditions like Chiari malformation may lead to transitional hydrodynamics of the CSF, and a prudent calibration of numerical approach is necessary to avoid overlook of such phenomena.

  20. Recent trends in heavy precipitation extremes over Germany: A thorough intercomparison between different statistical approaches

    Science.gov (United States)

    Donner, Reik; Passow, Christian

    2016-04-01

    comparison with GEV and GP-based approaches, quantile regression approaches thus allow for more flexibility and make full use of all available observational values, no matter if extreme or not. Due to the latter fact, trends in extreme values can be more easily assessed based on shorter time series. However, the question under which conditions and to what extent regression and extreme value theory-based approaches provide consistent results has not yet been fully explored. In this study, we provide a thorough inter-comparison between the recent trends in extreme precipitation events (assessed in terms of daily precipitation sums) from a large set of German weather stations as revealed by the classical (monthly) block maxima method with linearly time-dependent GEV parameters and linear quantile regression of the full time series. For the study period from 1951 to 2006, our main findings are as follows: (1) The spatial patterns of quantile trends for various high (>90%) percentiles and trends in the location parameter of the GEV distribution are qualitatively consistent and exhibit significant correlations, which, however, clearly deviate from an ideal correspondence. (2) In comparison with the trend parameters, the intercepts of the respective linear models for the GEV location parameter and different quantiles exhibit considerably larger mutual correlation values. (3) Quantile regression indicates more stations with strongly positive trends in extreme precipitation than the block maxima method. Moreover, the significance statements provided by the GEV statistics are more conservative than those resulting from quantile regression. Significant upward trends are generally restricted to Southern and Western Germany and are almost completely absent in the Northeastern part of the country. (4) More complex GEV models including linear trends in both location and dispersion parameter need to be considered only for a small subset of all stations (202 out of 2342). In most cases

  1. Functional metagenomics of extreme environments.

    Science.gov (United States)

    Mirete, Salvador; Morgante, Verónica; González-Pastor, José Eduardo

    2016-04-01

    The bioprospecting of enzymes that operate under extreme conditions is of particular interest for many biotechnological and industrial processes. Nevertheless, there is a considerable limitation to retrieve novel enzymes as only a small fraction of microorganisms derived from extreme environments can be cultured under standard laboratory conditions. Functional metagenomics has the advantage of not requiring the cultivation of microorganisms or previous sequence information to known genes, thus representing a valuable approach for mining enzymes with new features. In this review, we summarize studies showing how functional metagenomics was employed to retrieve genes encoding for proteins involved not only in molecular adaptation and resistance to extreme environmental conditions but also in other enzymatic activities of biotechnological interest.

  2. Mitochondriogenesis genes and extreme longevity.

    Science.gov (United States)

    Santiago, Catalina; Garatachea, Nuria; Yvert, Thomas; Rodríguez-Romo, Gabriel; Santos-Lozano, Alejandro; Fiuza-Luces, Carmen; Lucia, Alejandro

    2013-02-01

    Genes of the proliferator-activated receptor delta (PPARD)-peroxisome proliferator-activated receptor γ coactivator 1α (PPARGC1A, also termed PGC1-α)-nuclear respiratory factor (NRF)-mitochondrial transcription Factor A (TFAM) mitochondriogenesis pathway can influence health/disease phenotypes, yet their association with extreme longevity is not known. We studied the association of five common polymorphisms in genes of this pathway (rs2267668, rs8192678, rs6949152, rs12594956, rs1937) and extreme longevity using a case (107 centenarians)-control (284 young adults) design. We found no between-group differences in allele/genotype frequencies, except for CC genotype in rs1937 (p=0.003), with no representation in controls (0%), versus 2.8% in centenarians (2 men, 1 woman). In summary, the studied genetic variants of the PPARD-PPARGC1A-NRF-TFAM pathway were not associated with extreme longevity, yet a marginal association could exist for rs1937.

  3. Extreme Conditions Modeling Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Coe, R. G.; Neary, V. S.; Lawson, M. J.; Yu, Y.; Weber, J.

    2014-07-01

    Sandia National Laboratories (SNL) and the National Renewable Energy Laboratory (NREL) hosted the Wave Energy Converter (WEC) Extreme Conditions Modeling (ECM) Workshop in Albuquerque, NM on May 13th-14th, 2014. The objective of the workshop was to review the current state of knowledge on how to model WECs in extreme conditions (e.g. hurricanes and other large storms) and to suggest how U.S. Department of Energy (DOE) and national laboratory resources could be used to improve ECM methods for the benefit of the wave energy industry.

  4. Automation Rover for Extreme Environments

    Science.gov (United States)

    Sauder, Jonathan; Hilgemann, Evan; Johnson, Michael; Parness, Aaron; Hall, Jeffrey; Kawata, Jessie; Stack, Kathryn

    2017-01-01

    Almost 2,300 years ago the ancient Greeks built the Antikythera automaton. This purely mechanical computer accurately predicted past and future astronomical events long before electronics existed1. Automata have been credibly used for hundreds of years as computers, art pieces, and clocks. However, in the past several decades automata have become less popular as the capabilities of electronics increased, leaving them an unexplored solution for robotic spacecraft. The Automaton Rover for Extreme Environments (AREE) proposes an exciting paradigm shift from electronics to a fully mechanical system, enabling longitudinal exploration of the most extreme environments within the solar system.

  5. Extreme Weather and Natural Disasters

    CERN Document Server

    Healey, Justin

    2012-01-01

    Australia is a vast land in which weather varies significantly in different parts of the continent. Recent extreme weather events in Australia, such as the Queensland floods and Victorian bushfires, are brutal reminders of nature's devastating power. Is global warming increasing the rate of natural disasters? What part do La Niña and El Niño play in the extreme weather cycle? Cyclones, floods, severe storms, bushfires, landslides, earthquakes, tsunamis - what are the natural and man-made causes of these phenomena, how predictable are they, and how prepared are we for the impacts of natural dis

  6. Uncommon upper extremity compression neuropathies.

    Science.gov (United States)

    Knutsen, Elisa J; Calfee, Ryan P

    2013-08-01

    Hand surgeons routinely treat carpal and cubital tunnel syndromes, which are the most common upper extremity nerve compression syndromes. However, more infrequent nerve compression syndromes of the upper extremity may be encountered. Because they are unusual, the diagnosis of these nerve compression syndromes is often missed or delayed. This article reviews the causes, proposed treatments, and surgical outcomes for syndromes involving compression of the posterior interosseous nerve, the superficial branch of the radial nerve, the ulnar nerve at the wrist, and the median nerve proximal to the wrist. Copyright © 2013 Elsevier Inc. All rights reserved.

  7. Statistical Model of Extreme Shear

    DEFF Research Database (Denmark)

    Hansen, Kurt Schaldemose; Larsen, Gunner Chr.

    2005-01-01

    In order to continue cost-optimisation of modern large wind turbines, it is important to continuously increase the knowledge of wind field parameters relevant to design loads. This paper presents a general statistical model that offers site-specific prediction of the probability density function...... by a model that, on a statistically consistent basis, describes the most likely spatial shape of an extreme wind shear event. Predictions from the model have been compared with results from an extreme value data analysis, based on a large number of full-scale measurements recorded with a high sampling rate...

  8. Stretch due to Penile Prosthesis Reservoir Migration

    Directory of Open Access Journals (Sweden)

    E. Baten

    2016-03-01

    Full Text Available A 43-year old patient presented to the emergency department with stretch, due to impossible deflation of the penile prosthesis, 4 years after successful implant. A CT-scan showed migration of the reservoir to the left rectus abdominis muscle. Refilling of the reservoir was inhibited by muscular compression, causing stretch. Removal and replacement of the reservoir was performed, after which the prosthesis was well-functioning again. Migration of the penile prosthesis reservoir is extremely rare but can cause several complications, such as stretch.

  9. Holographic complexity and spacetime singularities

    Energy Technology Data Exchange (ETDEWEB)

    Barbón, José L.F. [Instituto de Física Teórica IFT UAM/CSIC,C/ Nicolás Cabrera 13, Campus Universidad Autónoma de Madrid,Madrid 28049 (Spain); Rabinovici, Eliezer [Racah Institute of Physics, The Hebrew University,Jerusalem 91904 (Israel); Laboratoire de Physique Théorique et Hautes Energies, Université Pierre et Marie Curie, 4 Place Jussieu, 75252 Paris Cedex 05 (France)

    2016-01-15

    We study the evolution of holographic complexity in various AdS/CFT models containing cosmological crunch singularities. We find that a notion of complexity measured by extremal bulk volumes tends to decrease as the singularity is approached in CFT time, suggesting that the corresponding quantum states have simpler entanglement structure at the singularity.

  10. Environmental health aspects of drinking water-borne outbreak due to karst flooding: case study.

    Science.gov (United States)

    Dura, Gyula; Pándics, Tamás; Kádár, Mihály; Krisztalovics, Katalin; Kiss, Zoltánné; Bodnár, Judit; Asztalos, Agnes; Papp, Erzsébet

    2010-09-01

    Climate change may increase the incidence of waterborne diseases due to extreme rainfall events, and consequent microbiological contamination of the water source and supply. As a result of the complexity of the pathways from the surface to the consumer, it is difficult to detect an association between rainfall and human disease. The water supply of a Hungarian city, Miskolc (174,000 inhabitant), is mainly based on karstic water, a vulnerable underground water body. A large amount of precipitation fell on the catchment area of the karstic water source, causing an unusually strong karstic water flow and flooding, and subsequent microbiological contamination. The presence of several potential sources of contamination in the protective zone of the karstic water source should be emphasized. The water supplier was unprepared to treat the risk of waterborne outbreak caused by an extreme weather event. Public health intervention and hygienic measures were taken in line with epidemiological actions, focusing on the protection of consumers by providing safe drinking water. The contamination was identified, and measures were taken for risk reduction and prevention. This case study underlines the increasing importance of preparedness for extreme water events in order to protect the karstic water sources and to avoid waterborne outbreaks.

  11. 千米深井复杂运输条件特厚煤层综放支架设计及参数优化%Design and Parameters Optimization of Full-mechanized Top-coal Caving Powered Support for Extremely-thick Coal-seam under Complex Transportation Condition in 1000 m Deep Mine

    Institute of Scientific and Technical Information of China (English)

    张金虎

    2015-01-01

    为满足3号特厚煤层千米以上埋深、顶板控制要求和复杂运输条件,对不同采煤方法适应性和支架参数进行研究。研究结果表明:特厚煤层综放开采在回采率、成本控制、安全保障和设备配套等方面较分层和大采高综采具有较大优势,千米埋深特厚煤层所需支护强度为1.3~1.4MPa,支架设计ϕ300/220mm较大缸径立柱和1500mm较小中心距解决罐笼小尺寸运输和强力支护重型大设备之间的矛盾,采用铰接顶梁加强架前支护和方便运输,优化立柱布置保证足够的行人和操作空间,设置防倒防滑、双侧活动侧护板和抬底机构增强对较大倾角和较软底板的适应性。%In order to meet 1000m deep depth, roof controlling requirement and complex transportation condition of No. 3 extremely-thick coalseam, adaptability of different mining methods and powered support's parameters were researched. Results showed that full-mechanized top-coal caving mining had larger advantage in mining ratio, cost control, safety assurance and equipments matching, compared with slicing mining and large-mining-height full-mechanized mining method. For extremely-thick coalseam in 1000m deep mine, 1. 3-1. 4MPa supporting intensity, 300/220 cylinder diameter and 1500mm center distance was designed to solve the conflict of small size cage and large equipment. Articulated roof beam was applied to strengthening supporting and facilitating transportation. Prop arrangement was optimized to ensure enough pedestrian and operation space. Anti-slide and anti-dumping structure, side-guard plate and bottom-lift device was designed to strengthen adaptability for large inclined angle and soft floor.

  12. Complex Networks

    CERN Document Server

    Evsukoff, Alexandre; González, Marta

    2013-01-01

    In the last decade we have seen the emergence of a new inter-disciplinary field focusing on the understanding of networks which are dynamic, large, open, and have a structure sometimes called random-biased. The field of Complex Networks is helping us better understand many complex phenomena such as the spread of  deseases, protein interactions, social relationships, to name but a few. Studies in Complex Networks are gaining attention due to some major scientific breakthroughs proposed by network scientists helping us understand and model interactions contained in large datasets. In fact, if we could point to one event leading to the widespread use of complex network analysis is the availability of online databases. Theories of Random Graphs from Erdös and Rényi from the late 1950s led us to believe that most networks had random characteristics. The work on large online datasets told us otherwise. Starting with the work of Barabási and Albert as well as Watts and Strogatz in the late 1990s, we now know th...

  13. Understanding relations between breeding bird species and extreme weather

    Science.gov (United States)

    Allstadt, A.; Bateman, B.; Pidgeon, A. M.; Radeloff, V.; Vavrus, S. J.; Keuler, N.; Clayton, M.; Albright, T.; Thogmartin, W.; Heglund, P.

    2013-12-01

    Extreme weather events are increasing in frequency due to climate change. Extreme weather events like periods of drought or cold snaps may impose hardship on many animal and plant populations. However, little is known about biotic response to extreme events. For example, some species experience population size changes in association with extreme weather, and some do not. However the mechanisms responsible for observed declines in avian abundance following heat waves and drought are not clear. Our goal was to characterize the population changes of North American bird species in relation to temperature and precipitation extremes using North American Breeding Bird Survey (BBS) data. We derived standardized measures of extreme precipitation and air temperature based on phase 2 NASA Land Data Assimilation System (NLDAS-2), an hourly 1/8 degree resolution land surface forcing dataset, and modeled population responses, during the breeding season, of 363 bird species. Of those species in which a change was observed, many demonstrated decreases in total population size, suggesting either mortality or reproductive failure (or both) are the causative mechanisms of this decline. A greater proportion of population changes were associated with extreme conditions in the same year than in the previous year. Some species exhibited population decreases in areas of extreme weather and increases in areas with environmental conditions more favorable to breeding while overall abundance remained relatively constant, which might indicate movement. The patterns of bird population changes in relation to extreme weather events provide insight for planners as they consider modifications to our national protected area network that will limit threats posed by climate change to bird populations.

  14. Extreme weather: Subtropical floods and tropical cyclones

    Science.gov (United States)

    Shaevitz, Daniel A.

    Extreme weather events have a large effect on society. As such, it is important to understand these events and to project how they may change in a future, warmer climate. The aim of this thesis is to develop a deeper understanding of two types of extreme weather events: subtropical floods and tropical cyclones (TCs). In the subtropics, the latitude is high enough that quasi-geostrophic dynamics are at least qualitatively relevant, while low enough that moisture may be abundant and convection strong. Extratropical extreme precipitation events are usually associated with large-scale flow disturbances, strong ascent, and large latent heat release. In the first part of this thesis, I examine the possible triggering of convection by the large-scale dynamics and investigate the coupling between the two. Specifically two examples of extreme precipitation events in the subtropics are analyzed, the 2010 and 2014 floods of India and Pakistan and the 2015 flood of Texas and Oklahoma. I invert the quasi-geostrophic omega equation to decompose the large-scale vertical motion profile to components due to synoptic forcing and diabatic heating. Additionally, I present model results from within the Column Quasi-Geostrophic framework. A single column model and cloud-revolving model are forced with the large-scale forcings (other than large-scale vertical motion) computed from the quasi-geostrophic omega equation with input data from a reanalysis data set, and the large-scale vertical motion is diagnosed interactively with the simulated convection. It is found that convection was triggered primarily by mechanically forced orographic ascent over the Himalayas during the India/Pakistan flood and by upper-level Potential Vorticity disturbances during the Texas/Oklahoma flood. Furthermore, a climate attribution analysis was conducted for the Texas/Oklahoma flood and it is found that anthropogenic climate change was responsible for a small amount of rainfall during the event but the

  15. Are extreme events (statistically) special? (Invited)

    Science.gov (United States)

    Main, I. G.; Naylor, M.; Greenhough, J.; Touati, S.; Bell, A. F.; McCloskey, J.

    2009-12-01

    We address the generic problem of testing for scale-invariance in extreme events, i.e. are the biggest events in a population simply a scaled model of those of smaller size, or are they in some way different? Are large earthquakes for example ‘characteristic’, do they ‘know’ how big they will be before the event nucleates, or is the size of the event determined only in the avalanche-like process of rupture? In either case what are the implications for estimates of time-dependent seismic hazard? One way of testing for departures from scale invariance is to examine the frequency-size statistics, commonly used as a bench mark in a number of applications in Earth and Environmental sciences. Using frequency data however introduces a number of problems in data analysis. The inevitably small number of data points for extreme events and more generally the non-Gaussian statistical properties strongly affect the validity of prior assumptions about the nature of uncertainties in the data. The simple use of traditional least squares (still common in the literature) introduces an inherent bias to the best fit result. We show first that the sampled frequency in finite real and synthetic data sets (the latter based on the Epidemic-Type Aftershock Sequence model) converge to a central limit only very slowly due to temporal correlations in the data. A specific correction for temporal correlations enables an estimate of convergence properties to be mapped non-linearly on to a Gaussian one. Uncertainties closely follow a Poisson distribution of errors across the whole range of seismic moment for typical catalogue sizes. In this sense the confidence limits are scale-invariant. A systematic sample bias effect due to counting whole numbers in a finite catalogue makes a ‘characteristic’-looking type extreme event distribution a likely outcome of an underlying scale-invariant probability distribution. This highlights the tendency of ‘eyeball’ fits to unconsciously (but

  16. Managing Complex Network Operation with Predictive Analytics

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Zhenyu; Wong, Pak C.; Mackey, Patrick S.; Chen, Yousu; Ma, Jian; Schneider, Kevin P.; Greitzer, Frank L.

    2008-03-26

    Complex networks play an important role in modern societies. Their failures, such as power grid blackouts, would lead to significant disruption of people’s life, industry and commercial activities, and result in massive economic losses. Operation of these complex networks is an extremely challenging task due to their complex structures, wide geographical coverage, complex data/information technology systems, and highly dynamic and nonlinear behaviors. None of the complex network operation is fully automated; human-in-the-loop operation is critical. Given the complexity involved, there may be thousands of possible topological configurations at any given time. During an emergency, it is not uncommon for human operators to examine thousands of possible configurations in near real-time to choose the best option and operate the network effectively. In today’s practice, network operation is largely based on experience with very limited real-time decision support, resulting in inadequate management of complex predictions and inability to anticipate, recognize, and respond to situations caused by human errors, natural disasters, and cyber attacks. A systematic approach is needed to manage the complex operation paradigms and choose the best option in a near-real-time manner. This paper applies predictive analytics techniques to establish a decision support system for complex network operation management and help operators to predict potential network failures and adapt the network to adverse situations. The resultant decision support system enables continuous monitoring of network performance and turns large amounts of data into actionable information. Examples with actual power grid data are presented to demonstrate the capability of this proposed decision support system.

  17. Extreme conditions (p, T, H)

    Energy Technology Data Exchange (ETDEWEB)

    Mesot, J. [Lab. for Neutron Scattering ETH Zurich, Zurich (Switzerland) and Paul Scherrer Institute, Villigen (Switzerland)

    1996-11-01

    The aim of this paper is to summarize the sample environment which will be accessible at the SINQ. In order to illustrate the type of experiments which will be feasible under extreme conditions of temperature, magnetic field and pressure at the SINQ a few selected examples are also given. (author) 7 figs., 14 refs.

  18. Extreme cervical elongation after sacrohysteropexy

    NARCIS (Netherlands)

    Vierhout, M.E.; Futterer, J.J.

    2013-01-01

    We present a case of extreme cervical elongation with a cervix of 12 cm after an unusual operation in which the uterine corpus was directly fixed to the promontory, and which became symptomatic after 8 years. The possible pathophysiology of cervical elongation is discussed. Diagnosing a case of seve

  19. Applied extreme-value statistics

    Energy Technology Data Exchange (ETDEWEB)

    Kinnison, R.R.

    1983-05-01

    The statistical theory of extreme values is a well established part of theoretical statistics. Unfortunately, it is seldom part of applied statistics and is infrequently a part of statistical curricula except in advanced studies programs. This has resulted in the impression that it is difficult to understand and not of practical value. In recent environmental and pollution literature, several short articles have appeared with the purpose of documenting all that is necessary for the practical application of extreme value theory to field problems (for example, Roberts, 1979). These articles are so concise that only a statistician can recognise all the subtleties and assumptions necessary for the correct use of the material presented. The intent of this text is to expand upon several recent articles, and to provide the necessary statistical background so that the non-statistician scientist can recognize and extreme value problem when it occurs in his work, be confident in handling simple extreme value problems himself, and know when the problem is statistically beyond his capabilities and requires consultation.

  20. Astrobiology: Life in Extreme Environments

    Science.gov (United States)

    Kaur, Preeti

    2011-01-01

    Astrobiology is the study of the origin, evolution and distribution of life in the universe. It seeks to answer two important scientific questions: how did we get here and are we alone in the universe? Scientists begin by studying life on Earth and its limits. The discovery of extremophiles on Earth capable of surviving extremes encourages the…

  1. Extreme Energy Events Monitoring report

    CERN Document Server

    Baimukhamedova, Nigina

    2015-01-01

    Following paper reflects the progress I made on Summer Student Program within Extreme Energy Events Monitor project I was working on. During 8 week period I managed to build a simple detector system that is capable of triggering events similar to explosions (sudden change in sound levels) and measuring approximate location of the event. Source codes are available upon request and settings described further.

  2. Generic Hurricane Extreme Seas State

    DEFF Research Database (Denmark)

    Wehmeyer, Christof; Skourup, Jesper; Frigaard, Peter

    2012-01-01

    the US east coast and the Gulf of Mexico (1851 - 2009) and Japanese east coast (1951 -2009) form the basis for Weibull extreme value analyses to determine return period respective maximum wind speeds. Unidirectional generic sea state spectra are obtained by application of the empirical models...

  3. Astrobiology: Life in Extreme Environments

    Science.gov (United States)

    Kaur, Preeti

    2011-01-01

    Astrobiology is the study of the origin, evolution and distribution of life in the universe. It seeks to answer two important scientific questions: how did we get here and are we alone in the universe? Scientists begin by studying life on Earth and its limits. The discovery of extremophiles on Earth capable of surviving extremes encourages the…

  4. Climate extremes promote fatal co-infections during canine distemper epidemics in African lions.

    Directory of Open Access Journals (Sweden)

    Linda Munson

    Full Text Available Extreme climatic conditions may alter historic host-pathogen relationships and synchronize the temporal and spatial convergence of multiple infectious agents, triggering epidemics with far greater mortality than those due to single pathogens. Here we present the first data to clearly illustrate how climate extremes can promote a complex interplay between epidemic and endemic pathogens that are normally tolerated in isolation, but with co-infection, result in catastrophic mortality. A 1994 canine distemper virus (CDV epidemic in Serengeti lions (Panthera leo coincided with the death of a third of the population, and a second high-mortality CDV epidemic struck the nearby Ngorongoro Crater lion population in 2001. The extent of adult mortalities was unusual for CDV and prompted an investigation into contributing factors. Serological analyses indicated that at least five "silent" CDV epidemics swept through the same two lion populations between 1976 and 2006 without clinical signs or measurable mortality, indicating that CDV was not necessarily fatal. Clinical and pathology findings suggested that hemoparsitism was a major contributing factor during fatal epidemics. Using quantitative real-time PCR, we measured the magnitude of hemoparasite infections in these populations over 22 years and demonstrated significantly higher levels of Babesia during the 1994 and 2001 epidemics. Babesia levels correlated with mortalities and extent of CDV exposure within prides. The common event preceding the two high mortality CDV outbreaks was extreme drought conditions with wide-spread herbivore die-offs, most notably of Cape buffalo (Syncerus caffer. As a consequence of high tick numbers after the resumption of rains and heavy tick infestations of starving buffalo, the lions were infected by unusually high numbers of Babesia, infections that were magnified by the immunosuppressive effects of coincident CDV, leading to unprecedented mortality. Such mass mortality

  5. THE IMPACT OF EXTREME RISK EVENTS ON THE ECONOMY

    Directory of Open Access Journals (Sweden)

    Ionela-Daniela GĂITAN

    2016-02-01

    Full Text Available In this paper I wanted to highlight the impact of extreme risk events on the economy. The issue that I will approach in this paper is one of great importance, taking into account that extreme risk events that occur are  different  and are becoming more frequent  and harder to  control.  The quickly  development  of  these eventsrequires the implementation of a suitable risk management system. The complexity of this issue involves different approaches that can be interrelated in: computer science, mathematics, risk management, crisis management, andmodeling and simulation of extreme risk events. Natural disasters are rare events, but when they occur are causing a huge damage and an adequate management is necessary to return to a state of normality in a short time. To achieve our goal, in the first part of the paper, we presented the problems that an extreme risk event causes in a country when they occur. In the last part of the paper I presented analytical, statistical and econometric methods used in analysis of the impact on the economy of extreme risk events. Natural  disasters,  which  are  extreme  risk  events,  rarely  produce,  but  when  they  occur  causing  hugedamage and an adequate management is necessary to return to a state of normality in a short time.

  6. Defect formation in single layer graphene under extreme ultraviolet irradiation

    NARCIS (Netherlands)

    Gao, An; Zoethout, E.; Zoethout, E.; Sturm, Jacobus Marinus; Lee, Christopher James; Bijkerk, Frederik

    2014-01-01

    We study extreme ultraviolet (EUV) radiation induced defects in single-layer graphene. Two mechanisms for inducing defects in graphene were separately investigated: photon induced chemical reactions between graphene and background residual gases, and breaking sp2 bonds, due to photon and/or photoele

  7. Ischemic pain in the extremities and Raynaud's phenomenon.

    NARCIS (Netherlands)

    Devulder, J.; Suijlekom, H. van; Dongen, R.T.M. van; Diwan, S.; Mekhail, N.; Kleef, M. van; Huygen, F.

    2011-01-01

    Two important groups of disorders result from an insufficient blood supply to the extremities: critical vascular disease and the Raynaud's phenomenon. The latter can be subdivided into a primary and a secondary type. Critical ischemic disease is often caused by arteriosclerosis due to hypertension o

  8. Reducing uncertainty in prediction of dune erosion during extreme conditions

    NARCIS (Netherlands)

    Den Heijer, C.; Reniers, A.J.H.M.; Van de Graaff, J.; Van Gelder, P.H.A.J.M.

    2008-01-01

    Coastal dunes protect low lying coastal areas against the sea. Extreme waves and water levels during severe storms may cause breaching of the dunes. Consequently, serious damage due to flooding and direct wave attack could occur, resulting in loss of life and property. Proper coastal management impl

  9. Extremal non-BPS black holes and entropy extremization

    CERN Document Server

    Lópes-Cardoso, G; Lust, D; Perz, J; Cardoso, Gabriel Lopes; Grass, Viviane; Lust, Dieter; Perz, Jan

    2006-01-01

    At the horizon, a static extremal black hole solution in N=2 supergravity in four dimensions is determined by a set of so-called attractor equations which, in the absence of higher-curvature interactions, can be derived as extremization conditions for the black hole potential or, equivalently, for the entropy function. We contrast both methods by explicitly solving the attractor equations for a one-modulus prepotential associated with the conifold. We find that near the conifold point, the non-supersymmetric solution has a substantially different behavior than the supersymmetric solution. We analyze the stability of the solutions and the extrema of the resulting entropy as a function of the modulus. For the non-BPS solution the region of attractivity and the maximum of the entropy do not coincide with the conifold point.

  10. A parallel workload has extreme varibility

    CERN Document Server

    Henwood, R; Chapman, S C; McLay, R

    2016-01-01

    In both high-performance computing (HPC) environments and the public cloud, the duration of time to retrieve or save your results is simultaneously unpredictable and important to your over all resource budget. It is generally accepted ("Google: Taming the Long Latency Tail - When More Machines Equals Worse Results", Todd Hoff, highscalability.com 2012), but without a robust explanation, that identical parallel tasks do take different durations to complete -- a phenomena known as variability. This paper advances understanding of this topic. We carefully choose a model from which system-level complexity emerges that can be studied directly. We find that a generalized extreme value (GEV) model for variability naturally emerges. Using the public cloud, we find real-world observations have excellent agreement with our model. Since the GEV distribution is a limit distribution this suggests a universal property of parallel systems gated by the slowest communication element of some sort. Hence, this model is applicab...

  11. An Assessment of Direct and Indirect Economic Losses of Climatic Extreme Events

    Science.gov (United States)

    Otto, C.; Willner, S. N.; Wenz, L.; Levermann, A.

    2015-12-01

    Risk of extreme weather events like storms, heat extremes, and floods has already risen due to anthropogenic climate change and is likely to increase further under future global warming. Additionally, the structure of the global economy has changed importantly in the last decades. In the process of globalization, local economies have become more and more interwoven forming a complex network. Together with a trend towards lean production, this has resulted in a strong dependency of local manufacturers on global supply and value added chains, which may render the economic network more vulnerable to climatic extremes; outages of local manufacturers trigger indirect losses, which spread along supply chains and can even outstrip direct losses. Accordingly, in a comprehensive climate risk assessment these inter-linkages should be considered. Here, we present acclimate, an agent based dynamic damage propagation model. Its agents are production and consumption sites, which are interlinked by economic flows accounting for the complexity as well as the heterogeneity of the global supply network. Assessing the economic response on the timescale of the adverse event, the model permits to study temporal and spatial evolution of indirect production losses during the disaster and in the subsequent recovery phase of the economy. In this study, we focus on the dynamic economic resilience defined here as the ratio of direct to total losses. This implies that the resilience of the system under consideration is low if the high indirect losses are high. We find and assess a nonlinear dependence of the resilience on the disaster size. Further, we analyze the influence of the network structure upon resilience and discuss the potential of warehousing as an adaptation option.

  12. Rational calibration of three IEC extreme load cases

    DEFF Research Database (Denmark)

    Larsen, Gunner Chr.; Hansen, Kurt Schaldemose

    2008-01-01

    This paper presents a rational and consistent calibration of the IEC 61400-1 extreme load cases EOG, EWS and ECD based on a system of asymptotic statistical models on closed form. The models are based on simple and easily accessible mean wind speed and turbulence characteristics of the atmospheric...... boundary layer. Using the wind climate characteristics prescribed in the IEC 61400-1 code as input to the statistical model complex ensures consistency between the specified wind climate and the proposed extreme gust amplitudes. Differences and equalities between the present IEC specifications and proposed...

  13. Rational calibration of three IEC extreme load cases

    DEFF Research Database (Denmark)

    Larsen, Gunner Chr.; Hansen, Kurt Schaldemose

    2008-01-01

    This paper presents a rational and consistent calibration of the IEC 61400-1 extreme load cases EOG, EWS and ECD based on a system of asymptotic statistical models on closed form. The models are based on simple and easily accessible mean wind speed and turbulence characteristics of the atmospheric...... boundary layer. Using the wind climate characteristics prescribed in the IEC 61400-1 code as input to the statistical model complex ensures consistency between the specified wind climate and the proposed extreme gust amplitudes. Differences and equalities between the present IEC specifications and proposed...

  14. Neonatal cardiomyopathies and metabolic crises due to oxidative phosphorylation defects.

    Science.gov (United States)

    Schiff, Manuel; Ogier de Baulny, Hélène; Lombès, Anne

    2011-08-01

    Neonatal cardiomyopathies due to mitochondrial oxidative phosphorylation (OXPHOS) defects are extremely severe conditions which can be either isolated or included in a multi-organ disease, with or without metabolic crises, of which profound lactic acidosis is the prominent feature. Cardiomyopathy is more often hypertrophic than dilated. Antenatal manifestations such as fetal cardiomyopathy, arrhythmia and/or hydrops have been reported. Pathophysiological mechanisms are complex, going beyond ATP deficiency of the high-energy-consuming neonatal myocardium. Birth is a key metabolic period when the myocardium switches ATP production from anaerobic glycolysis to mitochondrial fatty acid oxidation and OXPHOS. Heart-specificity of the defect may be related to the specific localization of the defect, to the high myocardium dependency on OXPHOS, and/or to interaction between the primary genetic alteration and other factors such as modifier genes. Therapeutic options are limited but standardized diagnostic procedures are mandatory to confirm the OXPHOS defect and to identify its causal mutation, allowing genetic counseling and potential prenatal diagnosis.

  15. Complex links between natural tuberculosis and porcine circovirus type 2 infection in wild boar

    OpenAIRE

    Iratxe Díez-Delgado; Mariana Boadella; MariPaz Martín-Hernando; José Angel Barasona; Beatriz Beltrán-Beck; David González-Barrio; Marina Sibila; Joaquín Vicente; Garrido, Joseba M; Joaquim Segalés; Christian Gortazar

    2014-01-01

    Individuals in natural populations are exposed to a diversity of pathogens which results in coinfections. The aim of this study was to investigate the relation between natural infection with tuberculosis (TB) due to infection by bacteria of the Mycobacterium tuberculosis complex and porcine circovirus type 2 (PCV2) in free-ranging Eurasian wild boar (Sus scrofa). Apparent prevalence for TB lesions and PCV2 infection was extremely high in all age classes, including piglets (51% for TB; 85.7% f...

  16. The epidemiology of extreme hiking injuries in volcanic environments.

    Science.gov (United States)

    Heggie, Travis W; Heggie, Tracey M

    2012-01-01

    The objective of this review was to summarize the epidemiological literature for extreme hikers in volcanic environments and describe the incidence, nature and severity of injuries, the factors contributing to the injuries, and strategies for preventing injuries. Due to the relative newness of extreme hiking in volcanic environments, there are only a small handful of studies addressing the topic. Moreover, these studies are primarily focused on extreme hikers in Hawaii Volcanoes National Park. These studies found that the majority of extreme hikers in volcanic environments are inexperienced and unfamiliar with the potential hazards present in volcanic environments. The studies found that upper respiratory irritation resulting from exposure to volcanic gases and dehydration and scrapes, abrasions, lacerations, and thermal burns to the extremities were common injuries. The severity of the injuries ranged from simple on-site treat-and-release incidents to more severe incidents and even death. This review reveals a need for well-designed epidemiologic research from volcanic destinations outside of Hawaii that identify the nature and severity of injuries along with the factors contributing to injury incidents. There is also a demonstrated need for studies identifying preventive measures that reduce both the occurrence and severity of extreme hiking incidents in volcanic environments.

  17. Host-parasite interactions under extreme climatic conditions

    Institute of Scientific and Technical Information of China (English)

    J. MARTINEZ; S. MERINO

    2011-01-01

    The effect that climatic changes can exert on parasitic interactions represents a multifactor problem whose results are difficult to predict. The actual impact of changes will depend on their magnitude and the physiological tolerance of affected organisms. When the change is considered extreme (I.e. Unusual weather events that are at the extremes of the historical distribution for a given area), the probability of an alteration in an organisms' homeostasis increases dramatically. However, factors determining the altered dynamics of host-parasite interactions due to an extreme change are the same as those acting in response to changes of lower magnitude. Only a deep knowledge of these factors will help to produce more accurate predictive models for the effects of extreme changes on parasitic interactions. Extreme environmental conditions may affect pathogens directly when they include free-living stages in their life-cycles and indirectly through reduced resource availability for hosts and thus reduced ability to produce efficient anti-parasite defenses, or by effects on host density affecting transmission dynamics of diseases or the frequency of intraspecific contact. What are the consequences for host-parasite interactions? Here we summarize the present knowledge on three principal factors in determining host-parasite associations; biodiversity, population density and immunocompetence. In addition, we analyzed examples of the effects of environmental alteration of anthropogenic origin on parasitic systems because the effects are analogous to that exerted by an extreme climatic change.

  18. Aerosol forcing of extreme summer drought over North China

    Science.gov (United States)

    Zhang, Lixia; Wu, Peili; Zhou, Tianjun

    2017-03-01

    The frequency of extreme summer drought has been increasing in North China during the past sixty years, which has caused serious water shortages. It remains unclear whether anthropogenic forcing has contributed to the increasing extreme droughts. Using the National Centers for Environmental Prediction and the National Center for Atmospheric Research (NCEP/NCAR) re-analysis data and Coupled Model Intercomparison Project Phase 5 (CMIP5) model simulations with various combinations of historical forcings, the authors investigated the driving mechanism behind the observed changes. Metrological drought is usually measured by precipitation anomalies, which show lower fidelity in current climate models compared to large-scale circulation patterns. Based on NCEP/NCAR re-analysis, a linear relationship is firstly established between the weakest regional average 850 hPa southerly winds and extreme summer drought. This meridional winds index (MWI) is then used as a proxy for attribution of extreme North China drought using CMIP5 outputs. Examination of the CMIP5 simulations reveals that the probability of the extreme summer droughts with the first percentile of MWI for 1850–2004 under anthropogenic forcing has increased by 100%, on average, relative to a pre-industrial control run. The more frequent occurrence of extremely weak MWIs or drought over North China is ascribed from weakened climate and East Asian summer monsoon (EASM) circulation due to the direct cooling effect from increased aerosol.

  19. Impacts of Extreme Events on Human Health. Chapter 4

    Science.gov (United States)

    Bell, Jesse E.; Herring, Stephanie C.; Jantarasami, Lesley; Adrianopoli, Carl; Benedict, Kaitlin; Conlon, Kathryn; Escobar, Vanessa; Hess, Jeremy; Luvall, Jeffrey; Garcia-Pando, Carlos Perez; Quattrochi, Dale; Runkle, Jennifer; Schreck, Carl J., III

    2016-01-01

    Increased Exposure to Extreme Events Key Finding 1: Health impacts associated with climate-related changes in exposure to extreme events include death, injury, or illness; exacerbation of underlying medical conditions; and adverse effects on mental health[High Confidence]. Climate change will increase exposure risk in some regions of the United States due to projected increases in the frequency and/or intensity of drought, wildfires, and flooding related to extreme precipitation and hurricanes [Medium Confidence].Disruption of Essential Infrastructure Key Finding 2: Many types of extreme events related to climate change cause disruption of infrastructure, including power, water, transportation, and communication systems, that are essential to maintaining access to health care and emergency response services and safeguarding human health [High Confidence].Vulnerability to Coastal Flooding Key Finding 3: Coastal populations with greater vulnerability to health impacts from coastal flooding include persons with disabilities or other access and functional needs, certain populations of color, older adults, pregnant women and children, low-income populations, and some occupational groups [High Confidence].Climate change will increase exposure risk to coastal flooding due to increases in extreme precipitation and in hurricane intensity and rainfall rates, as well as sea level rise and the resulting increases in storm surge.

  20. Characterizing extreme and oppressive heat waves in Illinois

    Science.gov (United States)

    Ford, Trent W.; Schoof, Justin T.

    2017-01-01

    Heat waves are characteristic features of summertime climate in the Midwest United States and can have significant agricultural, hydrological, and societal impacts. Historically, heat waves in the Midwest state of Illinois have been either extreme (high temperature and low humidity) or oppressive (high temperature and high humidity) in nature, but our knowledge of the factors determining which heat wave type occurs is limited. We use self-organizing maps to classify synoptic-scale atmospheric circulation patterns associated with oppressive and extreme heat events and analysis of variance to evaluate the atmospheric and land surface features responsible for differences in humidity that characterize the two. We find that the majority of extreme and oppressive heat events are associated with similar synoptic-scale atmospheric conditions. Additionally, both locally evaporated moisture and advected moisture sources were important for determining which of the two heat wave types occurred. Specifically, oppressive heat waves were characterized by abundant antecedent precipitation, surplus soil moisture, and elevated evapotranspiration and related atmospheric humidity. Lower humidity levels during extreme heat wave events were driven by relative reductions in evapotranspiration due to limited soil water content. Overall, our results suggest that the onset of heat waves in Illinois is primarily driven by circulation features in the upper atmosphere; however, the distinction of extreme or oppressive heat wave is due to differences in boundary layer humidity, driven in part by land surface moisture availability for evapotranspiration.

  1. Control challenges for extremely large telescopes

    Science.gov (United States)

    MacMartin, Douglas G.

    2003-08-01

    The next generation of large ground-based optical telescopes are likely to involve a highly segmented primary mirror that must be controlled in the presence of wind and other disturbances, resulting in a new set of challenges for control. The current design concept for the California Extremely Large Telescope (CELT) includes 1080 segments in the primary mirror, with the out-of-plane degrees of freedom actively controlled. In addition to the 3240 primary mirror actuators, the secondary mirror of the telescope will also require at least 5 degree of freedom control. The bandwidth of both control systems will be limited by coupling to structural modes. I discuss three control issues for extremely large telescopes in the context of the CELT design, describing both the status and remaining challenges. First, with many actuators and sensors, the cost and reliability of the control hardware is critical; the hardware requirements and current actuator design are discussed. Second, wind buffeting due to turbulence inside the telescope enclosure is likely to drive the control bandwidth higher, and hence limitations resulting from control-structure-interaction must be understood. Finally, the impact on the control architecture is briefly discussed.

  2. Deep vein thrombosis of upper extremities due to reactive thrombocytosis in septic patients

    Directory of Open Access Journals (Sweden)

    Shakti Bedanta Mishra

    2014-01-01

    Full Text Available Deep venous thrombosis (DVT is not an uncommon condition in the intensive care unit (ICU, and having high morbidity and mortality. Upper limb DVT also is increasingly being recognized as a clinical entity. The presence of the indwelling catheter in neck veins is a risk for developing venous thrombus, which may be further aggravated by presence of thrombocytosis. In ICU patients with sepsis, reactive thrombocytosis has been found during the recovery phase. Here, we are presenting two cases, having thrombocytosis and central venous catheter who developed upper limb DVT.

  3. Prediction of survival after surgery due to skeletal metastases in the extremities

    DEFF Research Database (Denmark)

    Sørensen, M S; Gerds, T A; Hindsø, K

    2016-01-01

    AIMS: The purpose of this study was to develop a prognostic model for predicting survival of patients undergoing surgery owing to metastatic bone disease (MBD) in the appendicular skeleton. METHODS: We included a historical cohort of 130 consecutive patients (mean age 64 years, 30 to 85; 76 females....../54 males) who underwent joint arthroplasty surgery (140 procedures) owing to MBD in the appendicular skeleton during the period between January 2003 and December 2008. Primary cancer, pre-operative haemoglobin, fracture versus impending fracture, Karnofsky score, visceral metastases, multiple bony...... metastases and American Society of Anaesthesiologist's score were included into a series of logistic regression models. The outcome was the survival status at three, six and 12 months respectively. Results were internally validated based on 1000 cross-validations and reported as time-dependent area under...

  4. Erosion and channel changes due to extreme flooding in the Fourmile Creek catchment, Colorado

    Science.gov (United States)

    Wicherski, Will; Dethier, David P.; Ouimet, William B.

    2017-10-01

    Infrequent, large magnitude geomorphic events generate quantifiable change on geologically short timescales and are crucial to understanding landscape evolution. Airborne lidar surveys and field measurements were used to investigate floodplain erosion and deposition along a 19.5 km reach of Fourmile Creek, Colorado that was devastated by severe flooding in 2013 that followed a 2010 wildfire. > 350 mm of rain fell on the Fourmile catchment from September 9-15, 2013, generating discharge that exceeded bankfull for > 120 h at the Orodell gage, with local unit stream power > 300 W m- 2 throughout the study reach. Debris flows occurred on steep hillslopes and tributary channels in the most intensely burned areas. Lidar difference measurements and field studies highlight zones of local deposition along the study reach, but demonstrate overall net erosion of 0.25 m for the 19.5 km reach of Fourmile floodplain, mainly by channel widening. Tributary junctions where debris-flow sediment entered the floodplain and local decreases in unit stream power controlled some zones of deposition. Overall, mass balance calculations show that a total sediment loss of 91,000-161,000 m3 from the Fourmile Creek floodplain and hillslopes, which is broadly consistent with channel sediment flux estimates of 71,000-111,000 m3. Measurements from the Fourmile catchment demonstrate that floodplain erosion was a major source of sediment in the 2013 flood and demonstrate that infrequent events marked by long-duration flooding and high total energy expenditure can account for a large fraction of total sediment transport in mountain streams.

  5. Towns with extremely low mortality due to ischemic heart disease in Spain

    Directory of Open Access Journals (Sweden)

    Medrano María

    2012-03-01

    Full Text Available Abstract Background The cause of coronary disease inframortality in Spain is unknown. The aim of this study is to identify Spanish towns with very low ischemic heart disease mortality, describe their health and social characteristics, and analyze the relationship with a series of contextual factors. Methods We obtained the number of deaths registered for each of 8,122 Spanish towns in the periods 1989-1998 and 1999-2003. Expected deaths, standardized mortality ratio (SMR, smoothed Relative Risk (RR, and Posterior Probability (PP of RR > 1 were calculated using Bayesian hierarchical models. Inframortality was defined as any town that displayed an RR below the 10th percentile, an SMR of under 1 for both sexes, and a PP of RR > 1 less than or equal to 0.002 for male and 0.005 for female mortality, during the two periods covered. All the remaining towns, except for those with high mortality classified as "tourist towns", were selected as controls. The association among socioeconomic, health, dietary, lifestyle and vascular risk factors was analyzed using sequential mixed logistic regression models, with province as the random-effects variable. Results We identified 32 towns in which ischemic heart disease mortality was half the national rate and four times lower than the European Union rate, situated in lightly populated provinces spread across the northern half of Spain, and revealed a surprising pattern of geographic aggegation for 23 of the 32 towns. Variables related with inframortality were: a less aged population (OR 0.93, 95% CI 0.89-0.99; a contextual dietary pattern marked by a high fish content (OR 2.13, 95% CI 1.38-3.28 and wine consumption (OR 1.50, 95% CI 1.08-2.07; and a low prevalence of obesity (OR 0.47, 95% CI 0.22-1.01; and, in the case of towns of over 1000 inhabitants, a higher physician-population ratio (OR 3.80, 95% CI 1.17-12.3. Conclusions Results indicate that dietary and health care factors have an influence on inframortality. The geographical aggregation suggests that other factors with a spatial pattern, e.g., genetic or environmental might also be implicated. These results will have to be confirmed by studies in situ, with objective measurements at an individual level.

  6. Extrapolation of extreme response for different mooring line systems of floating wave energy converters

    DEFF Research Database (Denmark)

    Ambühl, Simon; Sterndorff, Martin; Sørensen, John Dalsgaard

    2014-01-01

    Mooring systems for floating wave energy converters (WECs) are a major cost driver. Failure of mooring systems often occurs due to extreme loads. This paper introduces an extrapolation method for extreme response which accounts for the control system of a WEC that controls the loads onto the stru......Mooring systems for floating wave energy converters (WECs) are a major cost driver. Failure of mooring systems often occurs due to extreme loads. This paper introduces an extrapolation method for extreme response which accounts for the control system of a WEC that controls the loads onto...... the structure and the harvested power of the device as well as the fact that extreme loads may occur during operation and not at extreme wave states when the device is in storm protection mode. The extrapolation method is based on shortterm load time series and applied to a case study where up-scaled surge load...

  7. [Sports and extreme conditions. Cardiovascular incidence in long term exertion and extreme temperatures (heat, cold)].

    Science.gov (United States)

    Melin, B; Savourey, G

    2001-06-30

    During ultra-endurance exercise, both increase in body temperature and dehydration due to sweat losses, lead to a decrease in central blood volume. The heart rate drift allows maintaining appropriate cardiac output, in order to satisfy both muscle perfusion and heat transfer requirements by increasing skin blood flow. The resulting dehydration can impair thermal regulation and increase the risks of serious accidents as heat stroke. Endurance events, lasting more than 8 hours, result in large sweat sodium chloride losses. Thus, ingestion of large amounts of water with poor salt intake can induce symptomatic hyponatremia (plasma sodium extreme condition.

  8. Extreme Conditions Modeling Workshop Report

    Energy Technology Data Exchange (ETDEWEB)

    Coe, Ryan Geoffrey [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Neary, Vincent Sinclair [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Lawon, Michael J. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Yu, Yi-Hsiang [National Renewable Energy Lab. (NREL), Golden, CO (United States); Weber, Jochem [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-07-01

    Sandia National Laboratories (SNL) and the National Renewable Energy Laboratory (NREL) hosted the Wave Energy Converter (WEC) Extreme Conditions Modeling (ECM) Workshop in Albuquerque, New Mexico on May 13–14, 2014. The objective of the workshop was to review the current state of knowledge on how to numerically and experimentally model WECs in extreme conditions (e.g. large ocean storms) and to suggest how national laboratory resources could be used to improve ECM methods for the benefit of the wave energy industry. More than 30 U.S. and European WEC experts from industry, academia, and national research institutes attended the workshop, which consisted of presentations from W EC developers, invited keynote presentations from subject matter experts, breakout sessions, and a final plenary session .

  9. Cacti with Extremal PI Index

    Directory of Open Access Journals (Sweden)

    Chunxiang Wang

    2016-12-01

    Full Text Available The vertex PI index PI(G=∑ xy∈E(G [n xy (x‎+‎n xy (y] PI(G=∑xy∈E(G[nxy(x‎+‎nxy(y] is a distance-based molecular structure descriptor‎, ‎where n xy (x nxy(x denotes the number of vertices which are closer to the vertex x x than to the vertex y y and which has been the considerable research in computational chemistry dating back to Harold Wiener in 1947‎. ‎A connected graph is a cactus if any two of its cycles have at most one common vertex‎. ‎In this paper‎, ‎we completely determine the extremal graphs with the greatest and smallest vertex PI indices mong all cacti with a fixed number of vertices‎. ‎As a consequence‎, ‎we obtain the sharp bounds with corresponding extremal cacti and extend a known result‎.

  10. Racial Extremism in the Army

    Science.gov (United States)

    1998-04-01

    example, one soldier has a picture of Martin Luther King ;. another has a picture of Ronald Reagan). What is legal, appropriate action? (1) The particular...degree requirements for the 46h Judge Advocate Officer Graduate Course. 2 Virginia A. White, Killings Tied to Racism , FAYETTEVILLE OBSERVER-TIMES...causes to lure new members to their organizations. Lieutenant Colonel Edwin W. Anderson, Jr ., Right Wing Extremism in America and its Implications for

  11. Typologies of Extreme Longevity Myths

    OpenAIRE

    2010-01-01

    Purpose. Political, national, religious, and other motivations have led the media and even scientists to errantly accept extreme longevity claims prima facie. We describe various causes of false claims of extraordinary longevity. Design and Methods. American Social Security Death Index files for the period 1980–2009 were queried for individuals with birth and death dates yielding ages 110+ years of age. Frequency was compared to a list of age-validated supercentenarians maintained by the Ge...

  12. Promoting Exit from Violent Extremism

    DEFF Research Database (Denmark)

    Dalgaard-Nielsen, Anja

    2013-01-01

    A number of Western countries are currently adding exit programs targeting militant Islamists to their counterterrorism efforts. Drawing on research into voluntary exit from violent extremism, this article identifies themes and issues that seem to cause doubt, leading to exit. It then provides...... the influence attempt as subtle as possible, use narratives and self-affirmatory strategies to reduce resistance to persuasion, and consider the possibility to promote attitudinal change via behavioral change as an alternative to seek to influence beliefs directly....

  13. Predictability and possible earlier awareness of extreme precipitation across Europe

    Science.gov (United States)

    Lavers, David; Pappenberger, Florian; Richardson, David; Zsoter, Ervin

    2017-04-01

    Extreme hydrological events can cause large socioeconomic damages in Europe. In winter, a large proportion of these flood episodes are associated with atmospheric rivers, a region of intense water vapour transport within the warm sector of extratropical cyclones. When preparing for such extreme events, forecasts of precipitation from numerical weather prediction models or river discharge forecasts from hydrological models are generally used. Given the strong link between water vapour transport (integrated vapour transport IVT) and heavy precipitation, it is possible that IVT could be used to warn of extreme events. Furthermore, as IVT is located in extratropical cyclones, it is hypothesized to be a more predictable variable due to its link with synoptic-scale atmospheric dynamics. In this research, we firstly provide an overview of the predictability of IVT and precipitation forecasts, and secondly introduce and evaluate the ECMWF Extreme Forecast Index (EFI) for IVT. The EFI is a tool that has been developed to evaluate how ensemble forecasts differ from the model climate, thus revealing the extremeness of the forecast. The ability of the IVT EFI to capture extreme precipitation across Europe during winter 2013/14, 2014/15, and 2015/16 is presented. The results show that the IVT EFI is more capable than the precipitation EFI of identifying extreme precipitation in forecast week 2 during forecasts initialized in a positive North Atlantic Oscillation (NAO) phase. However, the precipitation EFI is superior during the negative NAO phase and at shorter lead times. An IVT EFI example is shown for storm Desmond in December 2015 highlighting its potential to identify upcoming hydrometeorological extremes.

  14. Moderate and extreme maternal obesity.

    LENUS (Irish Health Repository)

    Abdelmaboud, M O

    2012-05-01

    The aim of this study was to investigate the prevalence of moderate and extreme obesity among an Irish obstetric population over a 10-year period, and to evaluate the obstetric features of such pregnancies. Of 31,869 women delivered during the years 2000-2009, there were 306 women in the study group, including 173 in the moderate or Class 2 obese category (BMI 35-39.9) and 133 in the extreme or Class 3 obese category (BMI > or = 40).The prevalence of obese women with BMI > or = 35 was 9.6 per 1000 (0.96%), with an upward trend observed from 2.1 per 1000 in the year 2000, to 11.8 per 1000 in the year 2009 (P = 0.001). There was an increase in emergency caesarean section (EMCS) risk for primigravida versus multigravid women, within both obese categories (P < 0.001). However, there was no significant difference in EMCS rates observed between Class 2 and Class 3 obese women, when matched for parity. The prevalence of moderate and extreme obesity reported in this population is high, and appears to be increasing. The increased rates of abdominal delivery, and the levels of associated morbidity observed, have serious implications for such women embarking on pregnancy.

  15. Technology improves upper extremity rehabilitation.

    Science.gov (United States)

    Kowalczewski, Jan; Prochazka, Arthur

    2011-01-01

    Stroke survivors with hemiparesis and spinal cord injury (SCI) survivors with tetraplegia find it difficult or impossible to perform many activities of daily life. There is growing evidence that intensive exercise therapy, especially when supplemented with functional electrical stimulation (FES), can improve upper extremity function, but delivering the treatment can be costly, particularly after recipients leave rehabilitation facilities. Recently, there has been a growing level of interest among researchers and healthcare policymakers to deliver upper extremity treatments to people in their homes using in-home teletherapy (IHT). The few studies that have been carried out so far have encountered a variety of logistical and technical problems, not least the difficulty of conducting properly controlled and blinded protocols that satisfy the requirements of high-level evidence-based research. In most cases, the equipment and communications technology were not designed for individuals with upper extremity disability. It is clear that exercise therapy combined with interventions such as FES, supervised over the Internet, will soon be adopted worldwide in one form or another. Therefore it is timely that researchers, clinicians, and healthcare planners interested in assessing IHT be aware of the pros and cons of the new technology and the factors involved in designing appropriate studies of it. It is crucial to understand the technical barriers, the role of telesupervisors, the motor improvements that participants can reasonably expect and the process of optimizing IHT-exercise therapy protocols to maximize the benefits of the emerging technology.

  16. Typologies of Extreme Longevity Myths

    Directory of Open Access Journals (Sweden)

    Robert D. Young

    2010-01-01

    Full Text Available Purpose. Political, national, religious, and other motivations have led the media and even scientists to errantly accept extreme longevity claims prima facie. We describe various causes of false claims of extraordinary longevity. Design and Methods. American Social Security Death Index files for the period 1980–2009 were queried for individuals with birth and death dates yielding ages 110+ years of age. Frequency was compared to a list of age-validated supercentenarians maintained by the Gerontology Research Group who died during the same time period. Age claims of 110+ years and the age validation experiences of the authors facilitated a list of typologies of false age claims. Results. Invalid age claim rates increase with age from 65% at age 110-111 to 98% by age 115 to 100% for 120+ years. Eleven typologies of false claims were: Religious Authority Myth, Village Elder Myth, Fountain of Youth Myth (substance, Shangri-La Myth (geographic, Nationalist Pride, Spiritual Practice, Familial Longevity, Individual and/or Family Notoriety, Military Service, Administrative Entry Error, and Pension-Social Entitlement Fraud. Conclusions. Understanding various causes of false extreme age claims is important for placing current, past, and future extreme longevity claims in context and for providing a necessary level of skepticism.

  17. Extreme wind speeds in mixed climates revisited

    Energy Technology Data Exchange (ETDEWEB)

    Cook, Nicholas J.; Ian Harris, R. [Anemos Associates Ltd., 14 The Chestnuts, Hemel Hempstead HP3 0DZ (United Kingdom); Whiting, Richard [Department of Aerospace, University of Bristol, Bristol BS8 1TR (United Kingdom)

    2003-02-01

    The methodology for the analysis of extreme wind speeds in mixed climates originally proposed in 1978 by Gomes and Vickery is updated to take advantage of recent improvements in methodology and available data records. The revised methodology is demonstrated for two sites in Australia: Onslow and Brisbane. This work shows that the observed curvature in the upper tail is due to incomplete convergence to the Fisher-Tippett Type 1 asymptote and is not an indicator of Type 3 behaviour as sometimes supposed. It is also shown that moving from a reference epoch of 1 year to an epoch of 50 years frees the method from most of the rate-dependent assumptions, and simplifies the problem to a single, dominant wind mechanism.

  18. Heatshield for Extreme Entry Environment Technology (HEEET)

    Science.gov (United States)

    Venkatapathy, E.; Ellerby, D.; Stackpoole, M..; Peterson, K.; Gage, P.; Beerman, A.; Blosser, M.; Chinnapongse, R.; Dillman, R.; Feldman, J.; Gasch, M.; Munk, M.; Prabhu, D.; Poteet, C.

    2013-01-01

    Heat-shield for Extreme Entry Technology (HEEET) project is based on the 3-D Woven TPS, an emerging innovative and game changing technology funded by SMD and STMD to fill the ablative TPS gap that exists currently for reaching the depths of Saturn and Venus. Woven TPS technology will address the challenges currently faced by the Venus, Saturn, and higher speed sample return mission Science community due to lack of availability of the only TPS, namely Carbon Phenolic and enable the Science community to move forward with proposals in this decade with Woven TPS. This presentation describes the approach in maturing the technology in the next three years enabling NF-4 mission proposers to address the challenges of Venus, Saturn or higher speed sample return missions.

  19. Feasibility of Extreme Ultraviolet Active Optical Clock

    Institute of Scientific and Technical Information of China (English)

    ZHUANG Wei; CHEN Jing-Biao

    2011-01-01

    @@ We propose an experimental scheme of vacuum ultraviolet(VUV)and extreme ultraviolet(XUV)optical fre-quency standards with noble gas atoms.Considering metastable state 3P2 noble atoms pumped by a conventional discharging method,the atomic beam is collimated with transverse laser cooling at the metastable state and en-ters into the laser cavity in the proposed setup.Due to stimulated emission from the metasable state to the ground state inside the laser cavity consisting of VUV reflection coating mirrors,our calculations show that with enough population inversion to compensate for the cavity loss,an active optical frequency standard at VUV and XUV is feasible.

  20. A model for globular cluster extreme anomalies

    Science.gov (United States)

    D'Antona, F.; Ventura, P.

    2007-08-01

    In spite of the efforts made in recent years, there is still no comprehensive explanation for the chemical anomalies of globular cluster (GC) stars. Among these anomalies, the most striking is oxygen depletion, which reaches values down to [O/Fe] ~ -0.4 in most clusters, but in M13 it goes down to less than [O/Fe] ~ -1. In this work we suggest that the anomalies are due to the superposition of two different events, as follows. (i) Primordial self-enrichment; this is required to explain the oxygen depletion down to a minimum value [O/Fe] ~ -0.4. (ii) Extra mixing in a fraction of the stars already born with anomalous composition; these objects, starting with already low [O/Fe], will reduce the oxygen abundance down to the most extreme values. Contrary to other models that invoke extra mixing to explain the chemical anomalies, we suggest that this mixing is active only if there is a fraction of the stars in which the primordial composition is not only oxygen-depleted, but also extremely helium-rich (Y ~ 0.4), as found in a few GCs from their main-sequence multiplicity. We propose that the rotational evolution (and an associated extra mixing) of extremely helium-rich stars may be affected by the fact that they develop a very small or non-existent molecular weight barrier during the evolution. We show that extra mixing in these stars, having initial chemistry that has already been CNO processed, affects mainly the oxygen abundance, as well as (to a much smaller extent) the sodium abundance. The model also predicts a large fluorine depletion concomitant with the oxygen depletion, and a further enhancement of the surface helium abundance, which reaches values close to Y = 0.5 in the computed models. We stress that, in this tentative explanation, those stars that are primordially oxygen-depleted, but are not extremely helium-rich, do not suffer deep extra mixing.

  1. Extreme Precipitation and High-Impact Landslides

    Science.gov (United States)

    Kirschbaum, Dalia; Adler, Robert; Huffman, George; Peters-Lidard, Christa

    2012-01-01

    It is well known that extreme or prolonged rainfall is the dominant trigger of landslides; however, there remain large uncertainties in characterizing the distribution of these hazards and meteorological triggers at the global scale. Researchers have evaluated the spatiotemporal distribution of extreme rainfall and landslides at local and regional scale primarily using in situ data, yet few studies have mapped rainfall-triggered landslide distribution globally due to the dearth of landslide data and consistent precipitation information. This research uses a newly developed Global Landslide Catalog (GLC) and a 13-year satellite-based precipitation record from Tropical Rainfall Measuring Mission (TRMM) data. For the first time, these two unique products provide the foundation to quantitatively evaluate the co-occurence of precipitation and rainfall-triggered landslides globally. The GLC, available from 2007 to the present, contains information on reported rainfall-triggered landslide events around the world using online media reports, disaster databases, etc. When evaluating this database, we observed that 2010 had a large number of high-impact landslide events relative to previous years. This study considers how variations in extreme and prolonged satellite-based rainfall are related to the distribution of landslides over the same time scales for three active landslide areas: Central America, the Himalayan Arc, and central-eastern China. Several test statistics confirm that TRMM rainfall generally scales with the observed increase in landslide reports and fatal events for 2010 and previous years over each region. These findings suggest that the co-occurrence of satellite precipitation and landslide reports may serve as a valuable indicator for characterizing the spatiotemporal distribution of landslide-prone areas in order to establish a global rainfall-triggered landslide climatology. This research also considers the sources for this extreme rainfall, citing

  2. Electrical Drive Radiated Emissions Estimation in Terms of Input Control Using Extreme Learning Machines

    Directory of Open Access Journals (Sweden)

    A. Wefky

    2012-01-01

    Full Text Available With the increase of electrical/electronic equipment integration complexity, the electromagnetic compatibility (EMC becomes one of the key points to be respected in order to meet the constructor standard conformity. Electrical drives are known sources of electromagnetic interferences due to the motor as well as the related power electronics. They are the principal radiated emissions source in automotive applications. This paper shows that there is a direct relationship between the input control voltage and the corresponding level of radiated emissions. It also introduces a novel model using artificial intelligence techniques for estimating the radiated emissions of a DC-motor-based electrical drive in terms of its input voltage. Details of the training and testing of the developed extreme learning machine (ELM are described. Good agreement between the electrical drive behavior and the developed model is observed.

  3. MR imaging appearances of soft tissue flaps following reconstructive surgery of the lower extremity

    Energy Technology Data Exchange (ETDEWEB)

    Magerkurth, Olaf [Dept. of Radiology, Hospital Baden, Baden (Switzerland); Girish, Gandikota; Jacobson, Jon A.; Kim, Sung Moon; Brigido, Monica; Dong, Qian; Jamadar, David A. [Dept. of Radiology, University of Michigan Hospitals, Ann Arbor (United States)

    2015-02-15

    MR imaging appearances of different types of reconstructive muscle flaps following reconstructive surgery of the lower extremity with associated post-surgical changes due to altered anatomy, radiation, and potential complications, can be challenging. A multidisciplinary therapeutic approach to tumors allows for limb salvage therapy in a majority of the patients. Decision-making for specific types of soft tissue reconstruction is based on the body region affected, as well as the size and complexity of the defect. Hematomas and infections are early complications that can jeopardize flap viability. The local recurrence of a tumor within six months after a complete resection with confirmed tumor-free margins and adjuvant radiation therapy is rare. Identification of a new lesion similar to the initial tumor favors a finding of tumor recurrence.

  4. Rainfall variability and extremes over southern Africa: Assessment of a climate model to reproduce daily extremes

    Science.gov (United States)

    Williams, C. J. R.; Kniveton, D. R.; Layberry, R.

    2009-04-01

    It is increasingly accepted that that any possible climate change will not only have an influence on mean climate but may also significantly alter climatic variability. A change in the distribution and magnitude of extreme rainfall events (associated with changing variability), such as droughts or flooding, may have a far greater impact on human and natural systems than a changing mean. This issue is of particular importance for environmentally vulnerable regions such as southern Africa. The subcontinent is considered especially vulnerable to and ill-equipped (in terms of adaptation) for extreme events, due to a number of factors including extensive poverty, famine, disease and political instability. Rainfall variability and the identification of rainfall extremes is a function of scale, so high spatial and temporal resolution data are preferred to identify extreme events and accurately predict future variability. The majority of previous climate model verification studies have compared model output with observational data at monthly timescales. In this research, the assessment of ability of a state of the art climate model to simulate climate at daily timescales is carried out using satellite derived rainfall data from the Microwave Infra-Red Algorithm (MIRA). This dataset covers the period from 1993-2002 and the whole of southern Africa at a spatial resolution of 0.1 degree longitude/latitude. The ability of a climate model to simulate current climate provides some indication of how much confidence can be applied to its future predictions. In this paper, simulations of current climate from the UK Meteorological Office Hadley Centre's climate model, in both regional and global mode, are firstly compared to the MIRA dataset at daily timescales. This concentrates primarily on the ability of the model to simulate the spatial and temporal patterns of rainfall variability over southern Africa. Secondly, the ability of the model to reproduce daily rainfall extremes will

  5. Non-Stationary Dependence Structures for Spatial Extremes

    KAUST Repository

    Huser, Raphaël

    2016-03-03

    Max-stable processes are natural models for spatial extremes because they provide suitable asymptotic approximations to the distribution of maxima of random fields. In the recent past, several parametric families of stationary max-stable models have been developed, and fitted to various types of data. However, a recurrent problem is the modeling of non-stationarity. In this paper, we develop non-stationary max-stable dependence structures in which covariates can be easily incorporated. Inference is performed using pairwise likelihoods, and its performance is assessed by an extensive simulation study based on a non-stationary locally isotropic extremal t model. Evidence that unknown parameters are well estimated is provided, and estimation of spatial return level curves is discussed. The methodology is demonstrated with temperature maxima recorded over a complex topography. Models are shown to satisfactorily capture extremal dependence.

  6. Outcomes for extremely premature infants.

    Science.gov (United States)

    Glass, Hannah C; Costarino, Andrew T; Stayer, Stephen A; Brett, Claire M; Cladis, Franklyn; Davis, Peter J

    2015-06-01

    Premature birth is a significant cause of infant and child morbidity and mortality. In the United States, the premature birth rate, which had steadily increased during the 1990s and early 2000s, has decreased annually for 7 years and is now approximately 11.39%. Human viability, defined as gestational age at which the chance of survival is 50%, is currently approximately 23 to 24 weeks in developed countries. Infant girls, on average, have better outcomes than infant boys. A relatively uncomplicated course in the intensive care nursery for an extremely premature infant results in a discharge date close to the prenatal estimated date of confinement. Despite technological advances and efforts of child health experts during the last generation, the extremely premature infant (less than 28 weeks gestation) and extremely low birth weight infant (death and disability with 30% to 50% mortality and, in survivors, at least 20% to 50% risk of morbidity. The introduction of continuous positive airway pressure, mechanical ventilation, and exogenous surfactant increased survival and spurred the development of neonatal intensive care in the 1970s through the early 1990s. Routine administration of antenatal steroids during premature labor improved neonatal mortality and morbidity in the late 1990s. The recognition that chronic postnatal administration of steroids to infants should be avoided may have improved outcomes in the early 2000s. Evidence from recent trials attempting to define the appropriate target for oxygen saturation in preterm infants suggests arterial oxygen saturation between 91% and 95% (compared with 85%-89%) avoids excess mortality; however, final analyses of data from these trials have not been published, so definitive recommendations are still pending. The development of neonatal neurocritical intensive care units may improve neurocognitive outcomes in this high-risk group. Long-term follow-up to detect and address developmental, learning, behavioral, and

  7. Cutaneous allergic reaction due to alprazolam in a child

    Directory of Open Access Journals (Sweden)

    Meryem Ozlem Kutuk

    2016-06-01

    Full Text Available Cutaneous allergic reactions due to drug intake may be triggered by many types of drugs such as atropine, anticonvulsants and benzodiazepines. But allergic reactions due to benzodiazepines are extremely rare. Alprazolam is a benzodiazepine which may be useful for refractory idiopathic urticaria due to antihistaminergic effect. Although antihistaminergic effect of alprazolam, a cold urticaria case and an angioedema case induced by alprazolam are known in the literature. In the case, we present a child suffering from cutaneous allergic reaction due to alprazolam at the first dose taken. [Cukurova Med J 2016; 41(2.000: 400-402

  8. Palaeoflood extremes of the Lower Rhine

    Science.gov (United States)

    Toonen, W. H. J.; de Molenaar, M. M.; Bunnik, F. P. M.; Middelkoop, H.

    2012-04-01

    generated in a still forested natural catchment. According to present-day records, such discharges date roughly to a recurrence time of ~1/150-yr (e.g., the 12,600 m3s-1 flood of 1926 AD). At present, discharge waves are much steeper than millennia ago, due to deforestation since prehistoric times, and a managed river network. Correcting for these human impacts, the reconstructed palaeoflood would relate to a significant larger discharge, probably matching the current design discharge of the river dikes in the Netherlands. Although geological-based calculations of palaeoflood discharges are often less accurate than modern measurements, they provide unique information to bracket magnitudes of extreme events. Instead of accurate point-data, palaeodischarge outcomes can be used to verify previous estimates on the size of extreme events, and as thresholds of minimum discharge values, which can be used to narrow down uncertainty in previous estimations.

  9. Climate Model Simulation of Present and Future Extreme Events in Latin America and the Caribbean: What Spatial Resolution is Required?

    Science.gov (United States)

    Rowe, C. M.; Oglesby, R. J.; Mawalagedara, R.; Mohammad Abadi Kamarei, A.

    2015-12-01

    Latin America and the Caribbean are at risk of extreme climate events, including flooding rains, damaging winds, drought, heat waves, and in high elevation mountainous regions, excessive snowfalls. The causes of these events are numerous - flooding rains and damaging winds are often associated with tropical cyclones, but also can occur, either separately or in tandem, due to smaller, more localized storms. Similarly, heat waves and droughts can be large scale or localized, and frequently occur together (as excessive drying can lead to enhanced heating, while enhanced heating in turn promotes additional drying). Even in the tropics, extreme snow and ice events can have severe consequences due to avalanches, and also impact water resources. Understanding and modeling the climate controls behind these extreme events requires consideration of a range of time and space scales. A common strategy is to use a global climate model (GCM) to simulate the large-scale (~100km) daily atmospheric controls on extreme events. A limited area, high resolution regional climate model (RCM) is then employed to dynamically downscale the results, so as to better incorporate the influence of topography and, secondarily, the nature of the land cover. But what resolution is required to provide the necessary results, i.e., minimize biases due to improper resolution? In conjunction with our partners from participating Latin American and Caribbean nations, we have made an extensive series of simulations, both region-wide and for individual countries, using the WRF regional climate model to downscale output from a variety of GCMs, as well as Reanalyses (as a proxy for observations). The simulations driven by the Reanalyses are used for robust model verification against actual weather station observations. The simulations driven by GCMs are designed to provide projections of future climate, including importantly how the nature and number of extreme events may change through coming decades. Our

  10. The role of variation, error, and complexity in manufacturing defects

    Energy Technology Data Exchange (ETDEWEB)

    Hinckley, C.M. [Sandia National Labs., Livermore, CA (United States); Barkan, P. [Stanford Univ., CA (United States)

    1994-03-01

    Variation in component properties and dimensions is a widely recognized factor in product defects which can be quantified and controlled by Statistical Process Control methodologies. Our studies have shown, however, that traditional statistical methods are ineffective in characterizing and controlling defects caused by error. The distinction between error and variation becomes increasingly important as the target defect rates approach extremely low values. Motorola data substantiates our thesis that defect rates in the range of several parts per million can only be achieved when traditional methods for controlling variation are combined with methods that specifically focus on eliminating defects due to error. Complexity in the product design, manufacturing processes, or assembly increases the likelihood of defects due to both variation and error. Thus complexity is also a root cause of defects. Until now, the absence of a sound correlation between defects and complexity has obscured the importance of this relationship. We have shown that assembly complexity can be quantified using Design for Assembly (DFA) analysis. High levels of correlation have been found between our complexity measures and defect data covering tens of millions of assembly operations in two widely different industries. The availability of an easily determined measure of complexity, combined with these correlations, permits rapid estimation of the relative defect rates for alternate design concepts. This should prove to be a powerful tool since it can guide design improvement at an early stage when concepts are most readily modified.

  11. Carney Complex

    Science.gov (United States)

    ... Types of Cancer > Carney Complex Request Permissions Carney Complex Approved by the Cancer.Net Editorial Board , 11/2015 What is Carney complex? Carney complex is a hereditary condition associated with: ...

  12. Changes in Climate Extremes and Catastrophic Events in the Mongolian Plateau from 1951 to 2012

    DEFF Research Database (Denmark)

    Wang, Lei; Yao, Zhi-Jun; Jiang, Liguang;

    2016-01-01

    The spatiotemporal changes in 21 indices of extreme temperature and precipitation for the Mongolian Plateau from 1951 to 2012 were investigated on the basis of daily temperature and precipitation data from 70 meteorological stations. Changes in catastrophic events, such as droughts, floods...... in the daytime. The spatial changes in significant trends showed a good homogeneity and consistency in Inner Mongolia. Changes in the precipitation extremes were not as obvious as those in the temperature extremes. The spatial distributions in changes of precipitation extremes were complex. Adecreasing trend...

  13. Variability and long-term change in Australian temperature and precipitation extremes

    Directory of Open Access Journals (Sweden)

    Dörte Jakob

    2016-12-01

    We conclude that in assessing the likelihood of climate hazards, one needs to consider the modulation of climate extremes due to both long-term change and climate variability. Our findings imply that when planning for adaptation, different emphasis needs to be given to changing temperature and precipitation extremes.

  14. Hydrological extremes : Improving simulations of flood and drought in large river basins

    NARCIS (Netherlands)

    Wanders, N.

    2015-01-01

    Hydrological extremes regularly occur in all regions of the world and as such have large impacts on society. Floods and drought are the most severe hydrological extremes, in terms of their societal impact and potential economic damage. These events are amongst the most costly natural disasters, due

  15. The microbial sulfur cycle at extremely haloalkaline conditions of soda lakes

    NARCIS (Netherlands)

    Sorokin, D.Y.; Kuenen, J.G.; Muyzer, G.

    2011-01-01

    Soda lakes represent a unique ecosystem with extremely high pH (up to 11) and salinity (up to saturation) due to the presence of high concentrations of sodium carbonate in brines. Despite these double extreme conditions, most of the lakes are highly productive and contain a fully functional

  16. Why do people buy dogs with potential welfare problems related to extreme conformation and inherited disease?

    DEFF Research Database (Denmark)

    Sandøe, Peter; Kondrup, Sara Vincentzen; Bennett, P.C.

    2017-01-01

    number of dog breeds suffer from welfare problems due to extreme phenotypes and high levels of inherited diseases but the popularity of such breeds is not declining. Using a survey of owners of two popular breeds with extreme physical features (French Bulldog and Chihuahua), one with a high load...

  17. Can reanalysis datasets describe the persistent temperature and precipitation extremes over China?

    Science.gov (United States)

    Zhu, Jian; Huang, Dan-Qing; Yan, Pei-Wen; Huang, Ying; Kuang, Xue-Yuan

    2016-08-01

    The persistent temperature and precipitation extremes may bring damage to the economy and human due to their intensity, duration and areal coverage. Understanding the quality of reanalysis datasets in descripting these extreme events is important for detection, attribution and model evaluation. In this study, the performances of two reanalysis datasets [the twentieth century reanalysis (20CR) and Interim ECMWF reanalysis (ERA-Interim)] in reproducing the persistent temperature and precipitation extremes in China are evaluated. For the persistent temperature extremes, the two datasets can better capture the intensity indices than the frequency indices. The increasing/decreasing trend of persistent warm/cold extremes has been reasonably detected by the two datasets, particularly in the northern part of China. The ERA-Interim better reproduces the climatology and tendency of persistent warm extremes, while the 20CR has better skill to depict the persistent cold extremes. For the persistent precipitation extremes, the two datasets have the ability to reproduce the maximum consecutive 5-day precipitation. The two datasets largely underestimate the maximum consecutive dry days over the northern part of China, while overestimate the maximum consecutive wet days over the southern part of China. For the response of the precipitation extremes against the temperature variations, the ERA-Interim has good ability to depict the relationship among persistent precipitation extremes, local persistent temperature extremes, and global temperature variations over specific regions.

  18. Outcomes for Extremely Premature Infants

    Science.gov (United States)

    Glass, Hannah C.; Costarino, Andrew T.; Stayer, Stephen A.; Brett, Claire; Cladis, Franklyn; Davis, Peter J.

    2015-01-01

    Premature birth is a significant cause of infant and child morbidity and mortality. In the United States, the premature birth rate, which had steadily increased during the 1990s and early 2000s, has decreased annually for four years and is now approximately 11.5%. Human viability, defined as gestational age at which the chance of survival is 50%, is currently approximately 23–24 weeks in developed countries. Infant girls, on average, have better outcomes than infant boys. A relatively uncomplicated course in the intensive care nursery for an extremely premature infant results in a discharge date close to the prenatal EDC. Despite technological advances and efforts of child health experts during the last generation, the extremely premature infant (less than 28 weeks gestation) and extremely low birth weight infant (ELBW) (premature labor improved neonatal mortality and morbidity in the late 1990s. The recognition that chronic postnatal administration of steroids to infants should be avoided may have improved outcomes in the early 2000s. Evidence from recent trials attempting to define the appropriate target for oxygen saturation in preterm infants suggests arterial oxygen saturation between 91–95% (compared to 85–89%) avoids excess mortality. However, final analyses of data from these trials have not been published, so definitive recommendations are still pending The development of neonatal neurocognitive care visits may improve neurocognitive outcomes in this high-risk group. Long-term follow up to detect and address developmental, learning, behavioral, and social problems is critical for children born at these early gestational ages. The striking similarities in response to extreme prematurity in the lung and brain imply that agents and techniques that benefit one organ are likely to also benefit the other. Finally, since therapy and supportive care continue to change, the outcomes of ELBW infants are ever evolving. Efforts to minimize injury, preserve

  19. Gravity and Extreme Magnetism SMEX

    Science.gov (United States)

    2012-01-01

    The Gravity and Extreme Magnetism SMEX mission will be the first mission to catalogue the X-ray polarisation of many astrophysical objects including black-holes and pulsars. This first of its kind mission is enabled by the novel use of a time projection chamber as an X-ray polarimeter. The detector has been developed over the last 5 years, with the current effort charged toward a demonstration of it's technical readiness to be at level 6 prior to the preliminary design review. This talk will describe the design GEMS polarimeter and the results to date from the engineering test unit.

  20. Communication path for extreme environments

    Science.gov (United States)

    Jorgensen, Charles C. (Inventor); Betts, Bradley J. (Inventor)

    2010-01-01

    Methods and systems for using one or more radio frequency identification devices (RFIDs), or other suitable signal transmitters and/or receivers, to provide a sensor information communication path, to provide location and/or spatial orientation information for an emergency service worker (ESW), to provide an ESW escape route, to indicate a direction from an ESW to an ES appliance, to provide updated information on a region or structure that presents an extreme environment (fire, hazardous fluid leak, underwater, nuclear, etc.) in which an ESW works, and to provide accumulated thermal load or thermal breakdown information on one or more locations in the region.

  1. Ionization Chamber Measures Extreme Ultraviolet

    Science.gov (United States)

    Carlson, Robert W.

    1987-01-01

    Ionization chamber operates in nearly total photon absorption as stable, self-calibrating detector of ionizing extreme ultraviolet radiation. Working gas of instrument is neon; photoionization properties well known and readily applicable to absolute measurements. Designed for measurements of solar ultraviolet flux aboard sounding rocket, instrument used on Earth to measure ultraviolet radiation in vacuum systems. Ionization chamber collects positive neon ions and electrons produced by irradiation of neon gas by ultraviolet photons. Approximately one ion produced by each photon; consequently, photoionization current nearly proportional to photon flux.

  2. Advances in upper extremity prosthetics.

    Science.gov (United States)

    Zlotolow, Dan A; Kozin, Scott H

    2012-11-01

    Until recently, upper extremity prostheses had changed little since World War II. In 2006, the Defense Advanced Research Projects Agency responded to an increasing number of military amputees with the Revolutionizing Prosthetics program. The program has yielded several breakthroughs both in the engineering of new prosthetic arms and in the control of those arms. Direct brain-wave control of a limb with 22° of freedom may be within reach. In the meantime, advances such as individually powered digits have opened the door to multifunctional full and partial hand prostheses. Restoring sensation to the prosthetic limb remains a major challenge to full integration of the limb into a patient's self-image.

  3. Prevention of Lower Extremity Injuries in Basketball

    OpenAIRE

    2015-01-01

    Context: Lower extremity injuries are common in basketball, yet it is unclear how prophylactic interventions affect lower extremity injury incidence rates. Objective: To analyze the effectiveness of current lower extremity injury prevention programs in basketball athletes, focusing on injury rates of (1) general lower extremity injuries, (2) ankle sprains, and (3) anterior cruciate ligament (ACL) tears. Data Sources: PubMed, MEDLINE, CINAHL, SPORTDiscus, and the Cochrane Register of Controlle...

  4. Management of a Patient With Faciocervical Burns and Inhalational Injury Due to Hydrofluoric Acid Exposure.

    Science.gov (United States)

    Yuanhai, Zhang; Xingang, Wang; Liangfang, Ni; Chunmao, Han

    2014-05-01

    Hydrofluoric acid, a highly dangerous substance, can cause tissue damage and systemic toxicity by its unique mechanisms. Many cases of severe faciocervical burns due to hydrofluoric acid exposure are lethal. Herein, we present a case of 37-year-old man who suffered from hydrofluoric acid burns to his face, anterior neck, lips, and nasal cavity. On admission, this patient coughed with much sputum, and the chest auscultation detected rough breath sounds, wheezes, and very weak heart sounds, indicating possible inhalation injury. This case highlights the extreme complexity of managing this kind of injury. Timely and accurate wound treatment and respiratory tract care, as well as active systematic support treatment, played vital roles in the management of this patient.

  5. The potential power of robotics for upper extremity stroke rehabilitation.

    Science.gov (United States)

    Dukelow, Sean P

    2017-01-01

    Two decades of research on robots and upper extremity rehabilitation has resulted in recommendations from systematic reviews and guidelines on their use in stroke. Robotics are often cited for their ability to encourage mass practice as a means to enhance recovery of movement. Yet, stroke recovery is a complex process occurring across many aspects of neurologic function beyond movement. As newer devices are developed and enhanced assessments are integrated into treatment protocols, the potential of robotics to advance rehabilitation will continue to grow.

  6. Complexity, Robustness, and Performance

    NARCIS (Netherlands)

    B. Visser (Bauke)

    2002-01-01

    textabstractThis paper analyses the relationship between organizational complexity ( the degree of detail of information necessary to correctly assign agents to positions), robustness (the relative loss of performance due to mis-allocated agents), and performance. More complex structures are not

  7. Complexity, Robustness, and Performance

    NARCIS (Netherlands)

    B. Visser (Bauke)

    2002-01-01

    textabstractThis paper analyses the relationship between organizational complexity ( the degree of detail of information necessary to correctly assign agents to positions), robustness (the relative loss of performance due to mis-allocated agents), and performance. More complex structures are not nec

  8. Plasma physics of extreme astrophysical environments.

    Science.gov (United States)

    Uzdensky, Dmitri A; Rightley, Shane

    2014-03-01

    Among the incredibly diverse variety of astrophysical objects, there are some that are characterized by very extreme physical conditions not encountered anywhere else in the Universe. Of special interest are ultra-magnetized systems that possess magnetic fields exceeding the critical quantum field of about 44 TG. There are basically only two classes of such objects: magnetars, whose magnetic activity is manifested, e.g., via their very short but intense gamma-ray flares, and central engines of supernovae (SNe) and gamma-ray bursts (GRBs)--the most powerful explosions in the modern Universe. Figuring out how these complex systems work necessarily requires understanding various plasma processes, both small-scale kinetic and large-scale magnetohydrodynamic (MHD), that govern their behavior. However, the presence of an ultra-strong magnetic field modifies the underlying basic physics to such a great extent that relying on conventional, classical plasma physics is often not justified. Instead, plasma-physical problems relevant to these extreme astrophysical environments call for constructing relativistic quantum plasma (RQP) physics based on quantum electrodynamics (QED). In this review, after briefly describing the astrophysical systems of interest and identifying some of the key plasma-physical problems important to them, we survey the recent progress in the development of such a theory. We first discuss the ways in which the presence of a super-critical field modifies the properties of vacuum and matter and then outline the basic theoretical framework for describing both non-relativistic and RQPs. We then turn to some specific astrophysical applications of relativistic QED plasma physics relevant to magnetar magnetospheres and to central engines of core-collapse SNe and long GRBs. Specifically, we discuss the propagation of light through a magnetar magnetosphere; large-scale MHD processes driving magnetar activity and responsible for jet launching and propagation in

  9. Plasma physics of extreme astrophysical environments

    Science.gov (United States)

    Uzdensky, Dmitri A.; Rightley, Shane

    2014-03-01

    Among the incredibly diverse variety of astrophysical objects, there are some that are characterized by very extreme physical conditions not encountered anywhere else in the Universe. Of special interest are ultra-magnetized systems that possess magnetic fields exceeding the critical quantum field of about 44 TG. There are basically only two classes of such objects: magnetars, whose magnetic activity is manifested, e.g., via their very short but intense gamma-ray flares, and central engines of supernovae (SNe) and gamma-ray bursts (GRBs)—the most powerful explosions in the modern Universe. Figuring out how these complex systems work necessarily requires understanding various plasma processes, both small-scale kinetic and large-scale magnetohydrodynamic (MHD), that govern their behavior. However, the presence of an ultra-strong magnetic field modifies the underlying basic physics to such a great extent that relying on conventional, classical plasma physics is often not justified. Instead, plasma-physical problems relevant to these extreme astrophysical environments call for constructing relativistic quantum plasma (RQP) physics based on quantum electrodynamics (QED). In this review, after briefly describing the astrophysical systems of interest and identifying some of the key plasma-physical problems important to them, we survey the recent progress in the development of such a theory. We first discuss the ways in which the presence of a super-critical field modifies the properties of vacuum and matter and then outline the basic theoretical framework for describing both non-relativistic and RQPs. We then turn to some specific astrophysical applications of relativistic QED plasma physics relevant to magnetar magnetospheres and to central engines of core-collapse SNe and long GRBs. Specifically, we discuss the propagation of light through a magnetar magnetosphere; large-scale MHD processes driving magnetar activity and responsible for jet launching and propagation in

  10. Dynamics of extremal black holes

    CERN Document Server

    Giddings, Steven B

    1992-01-01

    Particle scattering and radiation by a magnetically charged, dilatonic black hole is investigated near the extremal limit at which the mass is a constant times the charge. Near this limit a neighborhood of the horizon of the black hole is closely approximated by a trivial product of a two-dimensional black hole with a sphere. This is shown to imply that the scattering of long-wavelength particles can be described by a (previously analyzed) two-dimensional effective field theory, and is related to the formation/evaporation of two-dimensional black holes. The scattering proceeds via particle capture followed by Hawking re-emission, and naively appears to violate unitarity. However this conclusion can be altered when the effects of backreaction are included. Particle-hole scattering is discussed in the light of a recent analysis of the two-dimensional backreaction problem. It is argued that the quantum mechanical possibility of scattering off of extremal black holes implies the potential existence of additional ...

  11. EXTREMAL CONTROL FOR PHOTOVOLTAIC PANELS

    Directory of Open Access Journals (Sweden)

    Genevieve DAPHIN TANGUY

    2016-11-01

    Full Text Available In this paper a methodology for extremal control of photovoltaic panels has been designed through the use of an embedded polynomial controller using robust approaches and algorithms. Also, a framework for testing solar trackers in a hard ware in the loop (HIL configuration has been established. Efficient gradient based optimization methods were put in place in order to determine the parameters of the employed photovoltaic panel, as well as for computing the Maximum Power Point (MPP. Further a numerical RST controller has been computed in order to allow the panel to follow the movement of the sun to obtain a maximum energetic efficiency. A robustness analysis and correction procedure has been done on the RST polynomial algorithm. The hardware in the loop configuration allows for the development of a test and development platform which can be used for bringing improvements to the current design and also test different control approaches. For this, a microcontroller based solution was chosen. The achieved performances of the closed loop photovoltaic panel (PP system are validated in simulation using the MATLAB / SIMULINK environment and the WinPim & WinReg dedicated software. As it will be seen further in this paper, the extremal control of this design resides in a sequential set of computations used for obtaining the new Maximum Power Point at each change in the system.

  12. Spectral-Spatial Classification of Hyperspectral Image Based on Kernel Extreme Learning Machine

    National Research Council Canada - National Science Library

    Chen Chen; Wei Li; Hongjun Su; Kui Liu

    2014-01-01

      Extreme learning machine (ELM) is a single-layer feedforward neural network based classifier that has attracted significant attention in computer vision and pattern recognition due to its fast learning speed and strong generalization...

  13. Complex Beauty

    OpenAIRE

    Franceschet, Massimo

    2014-01-01

    Complex systems and their underlying convoluted networks are ubiquitous, all we need is an eye for them. They pose problems of organized complexity which cannot be approached with a reductionist method. Complexity science and its emergent sister network science both come to grips with the inherent complexity of complex systems with an holistic strategy. The relevance of complexity, however, transcends the sciences. Complex systems and networks are the focal point of a philosophical, cultural ...

  14. Conference on Extreme Value Theory and Applications

    CERN Document Server

    Lechner, James; Simiu, Emil

    1994-01-01

    It appears that we live in an age of disasters: the mighty Missis­ sippi and Missouri flood millions of acres, earthquakes hit Tokyo and California, airplanes crash due to mechanical failure and the seemingly ever increasing wind speeds make the storms more and more frightening. While all these may seem to be unexpected phenomena to the man on the street, they are actually happening according to well defined rules of science known as extreme value theory. We know that records must be broken in the future, so if a flood design is based on the worst case of the past then we are not really prepared against floods. Materials will fail due to fatigue, so if the body of an aircraft looks fine to the naked eye, it might still suddenly fail if the aircraft has been in operation over an extended period of time. Our theory has by now penetrated the so­ cial sciences, the medical profession, economics and even astronomy. We believe that our field has come of age. In or~er to fully utilize the great progress in the the...

  15. Extreme cyclone events in the Arctic: Wintertime variability and trends

    Science.gov (United States)

    Rinke, A.; Maturilli, M.; Graham, R. M.; Matthes, H.; Handorf, D.; Cohen, L.; Hudson, S. R.; Moore, J. C.

    2017-09-01

    Typically 20-40 extreme cyclone events (sometimes called ‘weather bombs’) occur in the Arctic North Atlantic per winter season, with an increasing trend of 6 events/decade over 1979-2015, according to 6 hourly station data from Ny-Ålesund. This increased frequency of extreme cyclones is consistent with observed significant winter warming, indicating that the meridional heat and moisture transport they bring is a factor in rising temperatures in the region. The winter trend in extreme cyclones is dominated by a positive monthly trend of about 3-4 events/decade in November-December, due mainly to an increasing persistence of extreme cyclone events. A negative trend in January opposes this, while there is no significant trend in February. We relate the regional patterns of the trend in extreme cyclones to anomalously low sea-ice conditions in recent years, together with associated large-scale atmospheric circulation changes such as ‘blockinglike’ circulation patterns (e.g. Scandinavian blocking in December and Ural blocking during January-February).

  16. Changes in extreme regional sea level under global warming

    Science.gov (United States)

    Brunnabend, S.-E.; Dijkstra, H. A.; Kliphuis, M. A.; Bal, H. E.; Seinstra, F.; van Werkhoven, B.; Maassen, J.; van Meersbergen, M.

    2017-01-01

    An important contribution to future changes in regional sea level extremes is due to the changes in intrinsic ocean variability, in particular ocean eddies. Here, we study a scenario of future dynamic sea level (DSL) extremes using a high-resolution version of the Parallel Ocean Program and generalized extreme value theory. This model is forced with atmospheric fluxes from a coupled climate model which has been integrated under the IPCC-SRES-A1B scenario over the period 2000-2100. Changes in 10-year return time DSL extremes are very inhomogeneous over the globe and are related to changes in ocean currents and corresponding regional shifts in ocean eddy pathways. In this scenario, several regions in the North Atlantic experience an increase in mean DSL of up to 0.4 m over the period 2000-2100. DSL extremes with a 10-year return time increase up to 0.2 m with largest values in the northern and eastern Atlantic.

  17. The 2015 Oklahoma extreme precipitation: attribution of climate change

    Science.gov (United States)

    Nie, J.; Sobel, A. H.; Shaevitz, D.

    2016-12-01

    In a warming climate precipitation extremes increase disproportionally faster than the mean precipitation does. However, there are large uncertainties of the paces of the precipitation extreme increases among General Circulation Models (GCMs) in the tropics and subtropics, largely due to the deficiencies of convective parameterizations. A hierarchy of models, including regional models and cloud resolving models (CRM) with high resolutions to explicitly resolve convection, can provide insights to better constrain the GCM simulations. In this study, we apply a novel CRM modeling approach, the Column Quasi-Geostrophic (CQG) method, to examine responses of precipitation extreme to climate changes. The CQG approach uses a CRM in a relatively small domain with the large-scale vertical motion, which determines vertical advection of temperature and moisture, incorporated using the quasi-geostrophic omega equation. Comparing with other CRM studies that prescribe the large-scale vertical motion, this method allows us to examine the dynamical component of precipitation increases (, to which the GCMs largely disagree with each other) to warming in addition to the thermodynamical component of increases (about 7% per K). We model the 2015 Oklahoma extreme rainfall event with CQG method, with the present climate and two counterfactual environments representing the pre-industry and an even warmer climate. Results are analyzed to attribute the extreme precipitation to climate changes, and to quantify the involved mechanisms.

  18. Assessing the extreme overwash regime along an embayed urban beach

    Science.gov (United States)

    Silveira, Tanya M.; Taborda, Rui; Carapuço, Mafalda M.; Andrade, César; Freitas, Maria C.; Duarte, João F.; Psuty, Norbert P.

    2016-12-01

    Coastal overwash is one of the most important hazards affecting the coastal zone and therefore has been the focus of several studies related to the establishment of setback lines. However, studies of extreme overwash (EO) events along urban beaches backed by a seawall or structure are scarce, and reveal the difficulties associated with its assessment, measurement and validation. The Nazaré coastal urban area (located on the west coast of Portugal) is developed adjacent to an embayed reflective beach and is subject to frequent and localized inundation due to EO events capable of overtopping the protection seawall. The current work develops a methodological approach to simulate total water levels (TWL) and seawall overtopping occurrences in time and space, with the ultimate goal of identifying the factors that govern the extreme overwash regime. The method uses multi-decadal time series of site-specific wave and tide, and high-resolution topo-bathymetric data, and recreates the TWL time series for a 36-year period. The model is successfully validated against video imagery and maximum swash line data that provide information on the reach of the water levels measured during modal and extreme TWL conditions along the studied beach. This study establishes the importance of the interaction of the modal and extreme hydrodynamic processes with the beach and backshore morphology. The Nazaré embayment is in equilibrium with the alongshore-varying modal wave conditions, resulting in higher vulnerability of the most sheltered sector during extreme events.

  19. Hazards posed by distal ash transport and sedimentation from extreme volcanic eruptions

    Science.gov (United States)

    Sahagian, D. L.; Proussevitch, A. A.; White, C. M.; Klewicki, J.

    2016-12-01

    Volcanic ash injected into the upper troposphere and lower stratosphere poses a significant hazard to aviation and human security as a result of extreme, explosive eruptions. These have occurred in the recent geologic past, and are expected to occur again, now that modern society and its infrastructure is far more vulnerable than ever before. Atmospheric transport, dispersion, and sedimentation of Ash particles is controlled by fundamentally different processes than control other particles normally transported in the atmosphere due to their complex internal and external morphology. It is thus necessary to elucidate the fundamental processes of particle-fluid interactions in the upper troposphere and lower stratosphere, where most air traffic resides, and thereby enhance the capability of volcanic ash transport models to predict the ash concentration in distal regions that pose aviation and other hazards. Current Volcanic Ash Transport and Dispersion (VATD) models use simplistic stokes settling velocities for larger ash particles, and treat smaller ash particles (that are a large part of the hazard) merely as passive tracers. By incorporating the dynamics of fine ash particle-atmosphere interactions into existing VATD models provides the foundation for a much more accurate assessment framework applied to the hazard posed by specific future extreme eruptions, and thus dramatically reduce both the risk to air traffic and the cost of airport and flight closures, in addition to human health, water quality, agricultural, infrastructure hazards, as well as ice cap albedo and short term climate impacts.

  20. Extremity fractures in children: a hospital based study in Tehran

    Institute of Scientific and Technical Information of China (English)

    Ali Khaji; Mousa Zargar; Mojgan Karbakhsh

    2010-01-01

    Objective: Although long bone fracture in children is not life-threatening, it may cause major disability, loss of working days and severe psychological distress. We conducted this study to determine the pattern of extremity fracture due to trauma in children.Methods: During one year in six general hospitals in Tehran, trauma patients who were hospitalized for more than 24 hours and sustained injuries within seven days before admission were included in the study. The records of children (≤16 years old) hospitalized in six general hospitals in Tehran due to trauma were reviewed prospectively.Results: During the study period, 1274 children had sustained extremity fractures. Male to female ratio was 3.6/1, with the mean age of (10.3±4.2) years. Falls and traffic crashes were the main causes of injuries, with the percentages of 57.3% and 37.1%, respectively. Simple fall (falling on the ground) consisted 60% of patients that sustained fall-related injuries. Pedestrians and bicycle riders comprised most of the cases that were injured due to traffic crashes. Of our cases, 56.8% sustained fractures in the upper extremities and 43.2% in the lower extremities. Forearm was the most common fracture site (34.1%). Comparing our results in preschool and school-age children, falls were the main cause of injuries in both groups, but fractures of lower extremities were significantly more common in preschool children.Conclusions:Improvement of physical condition of sidewalks and crossings in roads will be necessary for prevention of injuries. More attention to safety of home environment should be paid for control of preschools' injury at home. Education of children and adults is necessary to reduce injuries resulting from road traffic crashes.

  1. Report from the 2nd Workshop on Extremely Large Databases

    Directory of Open Access Journals (Sweden)

    Jacek Becla

    2009-03-01

    Full Text Available The complexity and sophistication of large scale analytics in science and industry have advanced dramatically in recent years. Analysts are struggling to use complex techniques such as time series analysis and classification algorithms because their familiar, powerful tools are not scalable and cannot effectively use scalable database systems. The 2nd Extremely Large Databases (XLDB workshop was organized to understand these issues, examine their implications, and brainstorm possible solutions. The design of a new open source science database, SciDB that emerged from the first workshop in this series was also debated. This paper is the final report of the discussions and activities at this workshop.

  2. Radiographic assessment of congenital malformations of the upper extremity

    Energy Technology Data Exchange (ETDEWEB)

    Winfeld, Matthew J. [Perelman School of Medicine at the University of Pennsylvania, Department of Radiology, Musculoskeletal Division, Penn Medicine University City, Philadelphia, PA (United States); Otero, Hansel [Children' s National Medical Center, Department of Radiology, Washington, DC (United States)

    2016-09-15

    Congenital and developmental malformations of the upper extremity are uncommon and their diagnosis can challenge radiologists. Many complex classification systems exist, the latest of which accounts for the complex embryology and pathogenetic mechanisms that govern the formation of these anomalies. Using appropriate descriptors allows for more specific diagnosis and improved consultation with referring pediatricians and surgeons, helping to guide medical and surgical interventions and, if indicated, further investigation for associated abnormalities and underlying syndromes. We review the imaging characteristics of upper limb malformations to help pediatric radiologists better understand the classification and workup necessary in these cases. (orig.)

  3. Injuries in an Extreme Conditioning Program.

    Science.gov (United States)

    Aune, Kyle T; Powers, Joseph M

    2016-10-19

    was 2.5 times greater than that of more experienced athletes (≥6 months of experience). Of the 132 injuries, 23 (17%) required surgical intervention. Squat cleans, ring dips, overhead squats, and push presses were more likely to cause injury. Athletes reported that 35% of injuries were due to overexertion and 20% were due to improper technique. The estimated injury rate among athletes participating in this ECP was similar to the rate of injury in weightlifting and most other recreational activities. The shoulder or upper arm was the most commonly injured area, and previous shoulder injury predisposed to new shoulder injury. New athletes are at considerable risk of injury compared with more experienced athletes. Extreme conditioning programs are growing in popularity, and there is disagreement between science and anecdotal reports from athletes, coaches, and physicians about their relative safety. This study estimates the incidence of injury in extreme conditioning programs which appears to be similar to other weight-training programs. © 2016 The Author(s).

  4. The Relation Between Visual Impairment and Extremity Fractures

    Directory of Open Access Journals (Sweden)

    Berrak Şekeryapan

    2013-08-01

    Full Text Available Purpose: To evaluate the association between the development of extremity fracture and visual impairment in adults. Material and Method: This study included 56 patients (patient group aged 18 years or older who had extremity fractures due to a fall. The control group (n=42 was selected from visitors who had regular medical check-ups at our hospital. Each participant underwent a full ophthalmologic examination. Mean age was compared by Student’s t test. The other variables were compared by chi-square test. Results: The prevalence of subjects with visual impairment was significantly higher in the patients group (78.6% than in the control group (38.1% (p<0.05. The prevalence of treatable eye diseases such as cataract and refractive errors were significantly higher in the patient group than in the control group (p<0.05 for both. Twenty-eight patients (50% in the patient group and 8 subjects in the control group had visual acuities lower than 0.5 (p<0.05. Discussion: We have found that the prevalence of visual impairment was significantly higher in adults with extremity fractures due to falls than in the control group. Hence, we believe that regular ophthalmological examination in adults, providing regular use of eyeglasses in patients with refractive errors, and timely treatment of treatable eye diseases such as cataract could decrease the extremity fractures from falls in adults. (Turk J Ophthalmol 2013; 43: 250-2

  5. A Unique Case of Unilateral Lower Extremity Sparing Systemic Peripheral Gangrene

    Directory of Open Access Journals (Sweden)

    Alexey Markelov

    2012-01-01

    Full Text Available We present here the case of a 70-year-old female who developed a systemic peripheral gangrene in both of her upper extremities (all fingers and her right foot due to a severe septic shock requiring a systemic vasopressor therapy. Interestingly, the patient’s left foot remained spared from gangrenous changes possibly due to a chronic external iliac artery occlusion and thus the lower concentration of vasopressors in that extremity.

  6. Advanced Flip Chips in Extreme Temperature Environments

    Science.gov (United States)

    Ramesham, Rajeshuni

    2010-01-01

    The use of underfill materials is necessary with flip-chip interconnect technology to redistribute stresses due to mismatching coefficients of thermal expansion (CTEs) between dissimilar materials in the overall assembly. Underfills are formulated using organic polymers and possibly inorganic filler materials. There are a few ways to apply the underfills with flip-chip technology. Traditional capillary-flow underfill materials now possess high flow speed and reduced time to cure, but they still require additional processing steps beyond the typical surface-mount technology (SMT) assembly process. Studies were conducted using underfills in a temperature range of -190 to 85 C, which resulted in an increase of reliability by one to two orders of magnitude. Thermal shock of the flip-chip test articles was designed to induce failures at the interconnect sites (-40 to 100 C). The study on the reliability of flip chips using underfills in the extreme temperature region is of significant value for space applications. This technology is considered as an enabling technology for future space missions. Flip-chip interconnect technology is an advanced electrical interconnection approach where the silicon die or chip is electrically connected, face down, to the substrate by reflowing solder bumps on area-array metallized terminals on the die to matching footprints of solder-wettable pads on the chosen substrate. This advanced flip-chip interconnect technology will significantly improve the performance of high-speed systems, productivity enhancement over manual wire bonding, self-alignment during die joining, low lead inductances, and reduced need for attachment of precious metals. The use of commercially developed no-flow fluxing underfills provides a means of reducing the processing steps employed in the traditional capillary flow methods to enhance SMT compatibility. Reliability of flip chips may be significantly increased by matching/tailoring the CTEs of the substrate

  7. Predictability of extreme values in geophysical models

    Directory of Open Access Journals (Sweden)

    A. E. Sterk

    2012-09-01

    Full Text Available Extreme value theory in deterministic systems is concerned with unlikely large (or small values of an observable evaluated along evolutions of the system. In this paper we study the finite-time predictability of extreme values, such as convection, energy, and wind speeds, in three geophysical models. We study whether finite-time Lyapunov exponents are larger or smaller for initial conditions leading to extremes. General statements on whether extreme values are better or less predictable are not possible: the predictability of extreme values depends on the observable, the attractor of the system, and the prediction lead time.

  8. Predicting the flow in the floodplains with evolving land occupations during extreme flood events (FlowRes ANR project

    Directory of Open Access Journals (Sweden)

    Proust Sébastien

    2016-01-01

    Full Text Available Flood hazards (flow depth and velocity must be accurately assessed in high-risk areas during extreme flood events. However, the prediction of the very high flows is not an easy task due to the lack of field data and to the strong link between flow resistance and the land occupation of the floodplain. Confinement and inhomogeneity in lateral and longitudinal directions of hydraulic roughness strongly vary with return period T. The physical processes are complex, some still largely unexplored, and the assumptions linked to numerical modelling cannot be validated without field data. The FlowRes project (2015-2018, funded by the French National Research Agency (ANR, aims at improving the flood hazard assessment in floodplains in: 1 investigating in laboratory the hydrodynamic structure associated with extreme flood flows for various land occupations and flow discharge magnitudes; 2 assessing if the existing numerical modelling practices used for T ~ 100 years are still valid for extreme events with T > 1000 years, relying on the experimental data and on one field case. This paper reports some results obtained during the first year of the project.

  9. [Disease burden of extreme treatment anxiety; quality of life for patients with and without extreme dental treatment anxiety].

    Science.gov (United States)

    Vermaire, J H; van Houtem, C M H H; Ross, J N; Schuller, A A

    2017-09-01

    In this study, a comparison was made between disease-specific (oral health-related) quality of life (OHQoL), measured with the OHIP-14 questionnaire, and generic (general health-related) quality of life (GHQoL), measured with the EQ5D-5L questionnaire, in patients with and without extreme dental treatment anxiety. A total of 76 patients who could not be treated due to extreme dental treatment anxiety were referred to a centre for special dentistry. These patients were matched, according to age, gender and socioeconomic status, with participants in an epidemiological study on oral health (n = 1125). Wilcoxon signed-rank tests were used on both groups to compare GHQoL and OHQoL. The total OHIP score was higher (representing a lower quality of life) in the patient group than in the control group. Anxiety patients scored higher on all 7 domains of the OHIP-14. With respect to general quality of life, patients with extreme treatment anxiety were found to report lower utility scores than the matched control group. With these results, a total disease burden of 74,000 disability-adjusted life years (DALYs) was calculated for extreme treatment anxiety in the Netherlands. The findings of this study reveal that having extreme dental treatment anxiety results in a significant disease burden in the Netherlands.

  10. Using participatory agent-based models to measure flood managers' decision thresholds in extreme event response

    Science.gov (United States)

    Metzger, A.; Douglass, E.; Gray, S. G.

    2016-12-01

    Extreme flooding impacts to coastal cities are not only a function of storm characteristics, but are heavily influenced by decision-making and preparedness in event-level response. While recent advances in climate and hydrological modeling make it possible to predict the influence of climate change on storm and flooding patterns, flood managers still face a great deal of uncertainty related to adapting organizational responses and decision thresholds to these changing conditions. Some decision thresholds related to mitigation of extreme flood impacts are well-understood and defined by organizational protocol, but others are difficult to quantify due to reliance on contextual expert knowledge, experience, and complexity of information necessary to make certain decisions. Our research attempts to address this issue by demonstrating participatory modeling methods designed to help flood managers (1) better understand and parameterize local decision thresholds in extreme flood management situations, (2) collectively learn about scaling management decision thresholds to future local flooding scenarios and (3) identify effective strategies for adaptating flood mitigation actions and organizational response to climate change-intensified flooding. Our agent-based system dynamic models rely on expert knowledge from local flood managers and sophisticated, climate change-informed hydrological models to simulate current and future flood scenarios. Local flood managers from interact with these models by receiving dynamic information and making management decisions as a flood scenario progresses, allowing parametrization of decision thresholds under different scenarios. Flooding impacts are calculated in each iteration as a means of discussing effectiveness of responses and prioritizing response alternatives. We discuss the findings of this participatory modeling and educational process from a case study of Boston, MA, and discuss transferability of these methods to other types

  11. Mean and extreme sea level changes in the southwestern Baltic Sea

    Science.gov (United States)

    Schmidt, Jessica; Patzke, Justus; Dangendorf, Sönke; Arns, Arne; Jensen, Jürgen; Fröhle, Peter

    2016-04-01

    In this contribution an overview over the BMBF project AMSeL_Ostsee (2015-2018) for the assessment of mean and extreme sea level changes over the past 150 years in the southwestern Baltic Sea is presented. We compile several high resolution tide gauge records provided by the Water and Shipping Administration (WSV) along the German Baltic Sea coastline and merge them in internationally available data bases (UHSLC, PSMSL, and data officially available at national authorities). In addition, we make efforts in digitizing historical records to expand the number of available data sets in this complex and vulnerable coastal region. To separate absolute from relative long-term changes in sea level the vertical land motion (VLM) at specific sites is assessed. Possible sources of VLM are independently assessed by using different state-of-the-art approaches, that is: Glacial Isostatic Adjustment (GIA) modelled by viscoelastic Earth models, GPS derived VLM, and the difference between tide gauge and nearby satellite altimetry. The VLM corrected tide gauge records are further assessed for linear and non-linear trends as well as possible acceleration/deceleration patterns by applying advanced time series models such as Singular System Analysis (SSA) combined with a Monte-Carlo-Autoregressive-Padding approach (Wahl et al., 2010). These trend assessments are applied to mean and extreme sea levels independently to prove whether observed changes in extremes are either due to an underlying trend on mean sea levels or changes in storminess. References: Wahl, T., Jensen, J., Frank, T. (2011): On analysing sea level rise in the German Bight since 1844, NHESS, 10, 171-179.

  12. Sandy berm and beach-ridge formation in relation to extreme sea-levels

    DEFF Research Database (Denmark)

    Bendixen, Mette; Clemmensen, Lars B; Kroon, Aart

    2013-01-01

    The formation of berms and their transformation into beach ridges in a micro-tidal environment is coupled to wave run-up and overtopping during extreme sea levels. A straight-forward comparison between extreme sea levels due to storm-surges and active berm levels is impossible in the semi......-enclosed bays along the Baltic Sea. Quite often, the maximum water levels do not coincide with the maximum intensity of the wave driven processes because of seiches in the Baltic. In this paper, we look into the joined distribution of extreme water levels and high-energetic wave conditions at Feddet, a sandy...... of extreme sea level events is identified using thirty-three well described extreme events throughout a period of 15 years. Analysis of the meteorological conditions during these events revealed that berm formation only occurred during 20% of all extreme events when onshore winds, high-energy wave action...

  13. Effect of extreme value loss on long-term correlated time series

    Science.gov (United States)

    Yuan, Naiming; Fu, Zuntao; Li, Huiqun; Mao, Jiangyu

    2012-07-01

    Effects of extreme value loss on long-term correlated time series are analyzed by means of detrended fluctuation analysis (DFA) and power spectral density analysis. Weaker memory can be detected after removing of extreme values for the artificial long-term correlated data, indicating the emergence of extreme events may be closely related to long-term memory. For observational temperature records, similar results are obtained, but not in all stations. For example, in some stations, only extending of scaling range to smaller time scales occurs, which may be due to the asymmetric distribution of values in the record. By comparing our findings with previous works, clustered positions of the extreme events are recognized as an important property in long-term correlated records. Through a simple numerical test, close relations between extreme events and long-term memory are discovered, which is helpful for our understanding of the effects of extreme value loss on long-term correlated records.

  14. The Contribution of Extreme Precipitation to the Total Precipitation in China

    Institute of Scientific and Technical Information of China (English)

    SUN Jian-Qi

    2012-01-01

    Using daily precipitation data from weather stations in China, the variations in the contribution of extreme precipitation to the total precipitation are analyzed. It is found that extreme precipitation accounts for approximately one third of the total precipitation based on the overall mean for China. Over the past half century, extreme precipitation has played a dominant role in the year-to-year variability of the total precipitation. On the decadal time scale, the extreme precipitation makes different contributions to the wetting and drying regions of China. The wetting trends of particular regions are mainly attributed to increases in extreme precipitation; in contrast, the drying trends of other regions are mainly due to decreases in non-extreme precipitation.

  15. Interpretation of Extreme Scattering Events

    CERN Document Server

    Walker, M A

    2000-01-01

    Extreme Scattering Events are sometimes manifest in the light-curves of compact radio-quasars at frequencies of a few GHz. These events are not understood. The model which appears to offer the best explanation requires a new population of AU-sized, neutral gas clouds; these clouds would then make up a large fraction of the Galaxy's dark matter. Independent of the question of which theoretical model is correct, if we extrapolate the observed behaviour to low radio-frequencies, we expect that the sky should be criss-crossed by a network of narrow caustics, at frequencies below about 700 MHz. Consequently at these frequencies sources should typically manifest additional, faint images which are substantially delayed with respect to the primary image. Although some examples of this type of behaviour are already known, it is expected that these are just the tip of the iceberg, with strong selection biases having been imposed by the instrumentation employed to date.

  16. QCD matter in extreme environments

    CERN Document Server

    Fukushima, Kenji

    2011-01-01

    We review various theoretical approaches to the states of QCD matter out of quarks and gluons in extreme environments such as the high-temperature states at zero and finite baryon density and the dimensionally reduced state under an intense magnetic field. The topics at high temperature include the Polyakov loop and the 't Hooft loop in the perturbative regime, the Polyakov loop behaviour and the phase transition in some of non-perturbative methods; the strong-coupling expansion, the large-Nc limit and the holographic QCD models. These analyses are extended to hot and dense matter with a finite baryon chemical potential. We point out that the difficulty in the finite-density problem has similarity to that under a strong magnetic field. We make a brief summary of results related to the topological contents probed by the magnetic field and the Chiral Magnetic Effect. We also address the close connection to the (1+1) dimensional system.

  17. Extreme resilience in cochleate nanoparticles.

    Science.gov (United States)

    Bozó, Tamás; Brecska, Richárd; Gróf, Pál; Kellermayer, Miklós S Z

    2015-01-20

    Cochleates, prospective nanoscale drug delivery vehicles, are rolls of negatively charged phospholipid membrane layers. The membrane layers are held together by calcium ions; however, neither the magnitude of membrane interaction forces nor the overall mechanical properties of cochleates have been known. Here, we manipulated individual nanoparticles with atomic force microscopy to characterize their nanomechanical behavior. Their stiffness (4.2-12.5 N/m) and membrane-rupture forces (45.3-278 nN) are orders of magnitude greater than those of the tough viral nanoshells. Even though the fundamental building material of cochleates is a fluid membrane, the combination of supramolecular geometry, the cross-linking action of calcium, and the tight packing of the ions apparently lead to extreme mechanical resilience. The supramolecular design of cochleates may provide efficient protection for encapsulated materials and give clues to understanding biomolecular structures of similar design, such as the myelinated axon.

  18. Extreme ultraviolet Talbot interference lithography.

    Science.gov (United States)

    Li, Wei; Marconi, Mario C

    2015-10-05

    Periodic nanopatterns can be generated using lithography based on the Talbot effect or optical interference. However, these techniques have restrictions that limit their performance. High resolution Talbot lithography is limited by the very small depth of focus and the demanding requirements in the fabrication of the master mask. Interference lithography, with large DOF and high resolution, is limited to simple periodic patterns. This paper describes a hybrid extreme ultraviolet lithography approach that combines Talbot lithography and interference lithography to render an interference pattern with a lattice determined by a Talbot image. As a result, the method enables filling the arbitrary shaped cells produced by the Talbot image with interference patterns. Detailed modeling, system design and experimental results using a tabletop EUV laser are presented.

  19. Reach Envelope of Human Extremities

    Institute of Scientific and Technical Information of China (English)

    YANG Jingzhou(杨景周); ZHANG Yunqing(张云清); CHEN Liping(陈立平); ABDEL-MALEK Karim

    2004-01-01

    Significant attention in recent years has been given to obtain a better understanding of human joint ranges, measurement, and functionality, especially in conjunction with commands issued by the central nervous system. While researchers have studied motor commands needed to drive a limb to follow a path trajectory, various computer algorithms have been reported that provide adequate analysis of limb modeling and motion. This paper uses a rigorous mathematical formulation to model human limbs, understand their reach envelope, delineate barriers therein where a trajectory becomes difficult to control, and help visualize these barriers. Workspaces of a typical forearm with 9 degrees of freedom, a typical finger modeled as a 4- degree-of-freedom system, and a lower extremity with 4 degrees of freedom are discussed. The results show that using the proposed formulation, joint limits play an important role in distinguishing the barriers.

  20. Generic Hurricane Extreme Seas State

    DEFF Research Database (Denmark)

    Wehmeyer, Christof; Skourup, Jesper; Frigaard, Peter

    2012-01-01

    Extreme sea states, which the IEC 61400-3 (2008) standard requires for the ultimate limit state (ULS) analysis of offshore wind turbines are derived to establish the design basis for the conceptual layout of deep water floating offshore wind turbine foundations in hurricane affected areas...... data is required for a type specific conceptual design. ULS conditions for different return periods are developed, which can subsequently be applied in siteindependent analysis and conceptual design. Recordings provided by National Oceanic and Atmospheric Administration (NOAA), of hurricanes along...... for hurricane generates seas by Young (1998, 2003, and 2006), requiring maximum wind speeds, forward velocity and radius to maximum wind speed. An averaged radius to maximum sustained wind speeds, according to Hsu et al. (1998) and averaged forward speed of cyclonic storms are applied in the initial state...

  1. Pneumatic tourniquets in extremity surgery.

    LENUS (Irish Health Repository)

    Wakai, A

    2012-02-03

    Pneumatic tourniquets maintain a relatively bloodless field during extremity surgery, minimize blood loss, aid identification of vital structures, and expedite the procedure. However, they may induce an ischemia-reperfusion injury with potentially harmful local and systemic consequences. Modern pneumatic tourniquets are designed with mechanisms to regulate and maintain pressure. Routine maintenance helps ensure that these systems are working properly. The complications of tourniquet use include postoperative swelling, delay of recovery of muscle power, compression neurapraxia, wound hematoma with the potential for infection, vascular injury, tissue necrosis, and compartment syndrome. Systemic complications can also occur. The incidence of complications can be minimized by use of wider tourniquets, careful preoperative patient evaluation, and adherence to accepted principles of tourniquet use.

  2. Intensification of convective extremes driven by cloud-cloud interaction

    CERN Document Server

    Moseley, Christopher; Berg, Peter; Haerter, Jan O

    2015-01-01

    In a changing climate, a key role may be played by the response of convective-type cloud and precipitation to temperature changes. Yet, it is unclear if precipitation intensities will increase mainly due to modified thermodynamic forcing or due to stronger convective dynamics. In gradual self-organization, convective events produce highest intensities late in the day. Tracking rain cells throughout their life cycles, we find that interacting events respond strongly to changes in boundary conditions. Conversely, events without interaction remain unaffected. Increased surface temperature indeed leads to more interaction and higher precipitation extremes. However, a similar intensification occurs when leaving temperature unchanged but simply granting more time for self-organization.Our study implies that the convective field as a whole acquires a memory of past precipitation and inter-cloud dynamics, driving extremes. Our results implicate that the dynamical interaction between convective clouds must be incorpor...

  3. Design of manufacturable 3D extremal elastic microstructure

    DEFF Research Database (Denmark)

    Andreassen, Erik; Lazarov, Boyan Stefanov; Sigmund, Ole

    2014-01-01

    We present a method to design manufacturable extremal elastic materials. Extremal materials can possess interesting properties such as a negative Poisson's ratio. The effective properties of the obtained microstructures are shown to be close to the theoretical limit given by mathematical bounds......, and the deviations are due to the imposed manufacturing constraints. The designs are generated using topology optimization. Due to high resolution and the imposed robustness requirement they are manufacturable without any need for post-processing. This has been validated by the manufacturing of an isotropic material...... with a Poisson's ratio of ν=-0.5 and a bulk modulus of 0.2% times the solid base material's bulk modulus. © 2013 Elsevier Ltd. All rights reserved....

  4. Extremely red quasars in BOSS

    Science.gov (United States)

    Hamann, Fred; Zakamska, Nadia L.; Ross, Nicholas; Paris, Isabelle; Alexandroff, Rachael M.; Villforth, Carolin; Richards, Gordon T.; Herbst, Hanna; Brandt, W. Niel; Cook, Ben; Denney, Kelly D.; Greene, Jenny E.; Schneider, Donald P.; Strauss, Michael A.

    2017-01-01

    Red quasars are candidate young objects in an early transition stage of massive galaxy evolution. Our team recently discovered a population of extremely red quasars (ERQs) in the Baryon Oscillation Spectroscopic Survey (BOSS) that has a suite of peculiar emission-line properties including large rest equivalent widths (REWs), unusual `wingless' line profiles, large N V/Lyα, N V/C IV, Si IV/C IV and other flux ratios, and very broad and blueshifted [O III] λ5007. Here we present a new catalogue of C IV and N V emission-line data for 216 188 BOSS quasars to characterize the ERQ line properties further. We show that they depend sharply on UV-to-mid-IR colour, secondarily on REW(C IV), and not at all on luminosity or the Baldwin Effect. We identify a `core' sample of 97 ERQs with nearly uniform peculiar properties selected via i-W3 ≥ 4.6 (AB) and REW(C IV) ≥ 100 Å at redshifts 2.0-3.4. A broader search finds 235 more red quasars with similar unusual characteristics. The core ERQs have median luminosity ˜ 47.1, sky density 0.010 deg-2, surprisingly flat/blue UV spectra given their red UV-to-mid-IR colours, and common outflow signatures including BALs or BAL-like features and large C IV emission-line blueshifts. Their SEDs and line properties are inconsistent with normal quasars behind a dust reddening screen. We argue that the core ERQs are a unique obscured quasar population with extreme physical conditions related to powerful outflows across the line-forming regions. Patchy obscuration by small dusty clouds could produce the observed UV extinctions without substantial UV reddening.

  5. Dynamics of indicators of a metabolic exchange and condition of blood circulation of the bottom extremities after traction extension at patients with lumbar and sacral dorsopathy

    Directory of Open Access Journals (Sweden)

    Kotenko К.V.

    2013-12-01

    Full Text Available Aim: to study influence of traction therapy in a pulse mode in a complex with electrotherapy on a condition of blood circulation of the bottom extremities and level of a metabolic exchange. Material and methods. There had been examined 120 patients with a lumbar and sacral dorsopathy aged from 22 to 69 years (middle age of 49,5 years with prescription of a disease from 1 to 5 years, among them men of 34,2%, women of 65,8%. Results. The analysis of effects of various medical methods on a condition of local blood circulation in the bottom extremities showed that the most expressed its compensation is noted at complex application of mechanical pulse traction influence and electrotherapy for patients with a dorsopathy of lumbar and sacral department of a backbone that is confirmed by restoration to normal values of all indicators rheovasogramm. Conclusion. High clinical results of application of the combined medical and rehabilitation complex are based on compensation of local blood circulation that is shown in elimination of deficiency of blood supply due to improvement of a tone of arterial vessels and elimination of venous stagnation, and also due to increase of linear speed of a blood-groove and development of collateral blood circulation. Application of electrical impulse and mechanical traction influences, more at their combination promotes fermentative activity of the systems responsible for a protein exchange that is important for prevention of degenerate and dystrophic process progressing.

  6. Mangrove species' responses to winter air temperature extremes in China

    Science.gov (United States)

    Chen, Luzhen; Wang, Wenqing; Li, Qingshun Q.; Zhang, Yihui; Yang, Shengchang; Osland, Michael J.; Huang, Jinliang; Peng, Congjiao

    2017-01-01

    The global distribution and diversity of mangrove forests is greatly influenced by the frequency and intensity of winter air temperature extremes. However, our understanding of how different mangrove species respond to winter temperature extremes has been lacking because extreme freezing and chilling events are, by definition, relatively uncommon and also difficult to replicate experimentally. In this study, we investigated species-specific variation in mangrove responses to winter temperature extremes in China. In 10 sites that span a latitudinal gradient, we quantified species-specific damage and recovery following a chilling event, for mangrove species within and outside of their natural range (i.e., native and non-native species, respectively). To characterize plant stress, we measured tree defoliation and chlorophyll fluorescence approximately one month following the chilling event. To quantify recovery, we measured chlorophyll fluorescence approximately nine months after the chilling event. Our results show high variation in the geographic- and species-specific responses of mangroves to winter temperature extremes. While many species were sensitive to the chilling temperatures (e.g., Bruguiera sexangula and species in the Sonneratia and Rhizophora genera), the temperatures during this event were not cold enough to affect certain species (e.g., Kandelia obovata, Aegiceras corniculatum, Avicennia marina, and Bruguiera gymnorrhiza). As expected, non-native species were less tolerant of winter temperature extremes than native species. Interestingly, tidal inundation modulated the effects of chilling. In comparison with other temperature-controlled mangrove range limits across the world, the mangrove range limit in China is unique due to the combination of the following three factors: (1) Mangrove species diversity is comparatively high; (2) winter air temperature extremes, rather than means, are particularly intense and play an important ecological

  7. Complexity explained

    CERN Document Server

    Erdi, Peter

    2008-01-01

    This book explains why complex systems research is important in understanding the structure, function and dynamics of complex natural and social phenomena. Readers will learn the basic concepts and methods of complex system research.

  8. Necrotizing Fasciitis of the Lower Extremity Caused by Serratia marcescens A Case Report.

    Science.gov (United States)

    Heigh, Evelyn G; Maletta-Bailey, April; Haight, John; Landis, Gregg S

    2016-03-01

    Necrotizing fasciitis is a rare and potentially fatal infection, with mortality of up to 30%. This case report describes a patient recovering from a laryngectomy for laryngeal squamous cell cancer who developed nosocomial necrotizing fasciitis of the lower extremity due to Serratia marcescens . Only eight cases of necrotizing fasciitis exclusive to the lower extremity due to S marcescens have been previously reported. Patients with S marcescens necrotizing fasciitis of the lower extremity often have multiple comorbidities, are frequently immunosuppressed, and have a strikingly high mortality rate.

  9. Response of Simple, Model Systems to Extreme Conditions

    Energy Technology Data Exchange (ETDEWEB)

    Ewing, Rodney C. [Univ. of Michigan, Ann Arbor, MI (United States); Lang, Maik [Univ. of Michigan, Ann Arbor, MI (United States)

    2015-07-30

    The focus of the research was on the application of high-pressure/high-temperature techniques, together with intense energetic ion beams, to the study of the behavior of simple oxide systems (e.g., SiO2, GeO2, CeO2, TiO2, HfO2, SnO2, ZnO and ZrO2) under extreme conditions. These simple stoichiometries provide unique model systems for the analysis of structural responses to pressure up to and above 1 Mbar, temperatures of up to several thousands of kelvin, and the extreme energy density generated by energetic heavy ions (tens of keV/atom). The investigations included systematic studies of radiation- and pressure-induced amorphization of high P-T polymorphs. By studying the response of simple stoichiometries that have multiple structural “outcomes”, we have established the basic knowledge required for the prediction of the response of more complex structures to extreme conditions. We especially focused on the amorphous state and characterized the different non-crystalline structure-types that result from the interplay of radiation and pressure. For such experiments, we made use of recent technological developments, such as the perforated diamond-anvil cell and in situ investigation using synchrotron x-ray sources. We have been particularly interested in using extreme pressures to alter the electronic structure of a solid prior to irradiation. We expected that the effects of modified band structure would be evident in the track structure and morphology, information which is much needed to describe theoretically the fundamental physics of track-formation. Finally, we investigated the behavior of different simple-oxide, composite nanomaterials (e.g., uncoated nanoparticles vs. core/shell systems) under coupled, extreme conditions. This provided insight into surface and boundary effects on phase stability under extreme conditions.

  10. Extreme precipitation patterns reduced terrestrial ecosystem production across biomes

    Science.gov (United States)

    Zhang, Y.; Moran, S. M.; Nearing, M.; Ponce Campos, G. E.; Huete, A. R.; Buda, A. R.; Bosch, D. D.; Gunter, S. A.; Kitchen, S. G.; McNab, W.; Morgan, J. A.; McClaran, M. P.; Montoya, D. S.; Peters, D. P.; Starks, P. J.

    2012-12-01

    Precipitation regimes are predicted to shift to more extreme patterns that are characterized by more intense rainfall events and longer dry intervals, yet their ecological impacts on vegetation production remain uncertain across biomes in natural climatic conditions. This in situ study investigated the effects of novel climatic conditions on aboveground net primary production (ANPP) by combining a greenness index from satellite measurements and climatic records during 2000 to 2009 from 11 long-term experimental sites in multiple biomes and climates. Results showed that extreme precipitation patterns decreased the sensitivity of ANPP to total annual precipitation (PT), at the regional and decadal scales, leading to a mean 20% decrease in rain-use efficiency across biomes. Relative decreases in ANPP were greatest for arid grassland (16%) and Mediterranean forest (20%), and less for mesic grassland and temperate forest (3%). The co-occurrence of more heavy rainfall events and longer dry intervals caused greater water stress that resulted in reduced vegetation production. A new generalized model was developed to improve predictions of the ANPP response to changes in extreme precipitation patterns by using a function of both PT and an index of precipitation extremes. These findings suggest that extreme precipitation patterns have more substantial and complex effects on vegetation production across biomes, and are as important as total annual precipitation in understanding vegetation processes. With predictions of more extreme weather events, forecasts of ecosystem production should consider these non-linear responses to altered precipitation patterns associated with climate change. Figure. Relation of production across precipitation gradients for 11 sites for two groups (Low: R95p% definitions. The relations were significantly different for the two groups (F2, 106 = 18.51, P < 0.0001).

  11. Vertical structure of extreme currents in the Faroe-Bank Channel

    Directory of Open Access Journals (Sweden)

    C. Carollo

    2005-09-01

    Full Text Available Extreme currents are studied with the aim of understanding their vertical and spatial structures in the Faroe-Bank Channel. Acoustic Doppler Current Profiler time series recorded in 3 deployments in this channel were investigated. To understand the main features of extreme events, the measurements were separated into their components through filtering and tidal analysis before applying the extreme value theory to the surge component. The Generalized Extreme Value (GEV distribution and the Generalized Pareto Distribution (GPD were used to study the variation of surge extremes from near-surface to deep waters. It was found that this component alone is not able to explain the extremes measured in total currents, particularly below 500 m. Here the mean residual flow enhanced by tidal rectification was found to be the component feature dominating extremes. Therefore, it must be taken into consideration when applying the extreme value theory, not to underestimate the return level for total currents. Return value speeds up to 250 cm s–1 for 50/250 years return period were found for deep waters, where the flow is constrained by the topography at bearings near 300/330° It is also found that the UK Meteorological Office FOAM model is unable to reproduce either the magnitude or the form for the extremes, perhaps due to its coarse vertical and horizontal resolution, and is thus not suitable to model extremes on a regional scale.

    Keywords. Oceanography: Physical (Currents; General circulation; General or miscellaneous

  12. Upper extremity constraint-induced movement therapy in infantile hemiplegia

    Directory of Open Access Journals (Sweden)

    Selvam Ramachandran

    2011-01-01

    Full Text Available Infantile hemiplegia is one of the clinical forms of cerebral palsy that refers to impaired motor function of one half of the body owing to contralateral brain damage due to prenatal, perinatal and postnatal causes amongst which vascular lesion is the most common causative factor. We report here the effects of constraint-induced movement therapy in a five-year-old female child with infantile hemiplegia on improvement of upper extremity motor skills.

  13. When it rains, it pours: future climate extremes and health.

    Science.gov (United States)

    Patz, Jonathan A; Grabow, Maggie L; Limaye, Vijay S

    2014-01-01

    The accelerating accumulation of greenhouse gases in the Earth's atmosphere is changing global environmental conditions in unprecedented and potentially irreversible ways. Climate change poses a host of challenges to the health of populations through complex direct and indirect mechanisms. The direct effects include an increased frequency of heat waves, rising sea levels that threaten low-lying communities, anticipated extremes in the global hydrologic cycle (droughts, floods, and intense storms), and adverse effects on agricultural production and fisheries due to environmental stressors and changes in land use. Indirectly, climate change is anticipated to threaten health by worsening urban air pollution and increasing rates of infectious (particularly waterborne and vector-borne) disease transmission. To provide a state-of-the-science review on the health consequences of a changing climate. Environmental public health researchers have concluded that, on balance, adverse health outcomes will dominate under these changed climatic conditions. The number of pathways through which climate change can affect the health of populations makes this environmental health threat one of the largest and most formidable of the new century. Geographic location plays an influential role the potential for adverse health effects caused by climate change, and certain regions and populations are more vulnerable than others to expected health effects. Two kinds of strategies are available for responding to climate change: mitigation policies (which aim to reduce greenhouse gas emissions) and adaptation measures (relating to preparedness for anticipated impacts). To better understand and address the complex nature of health risks posed by climate change, interdisciplinary collaboration is critical. Efforts to move beyond our current reliance on fossil fuels to cleaner, more sustainable energy sources may offer some of the greatest health opportunities in more than a century and cobenefits

  14. Introduction to Complex Plasmas

    CERN Document Server

    Bonitz, Michael; Ludwig, Patrick

    2010-01-01

    Complex plasmas differ from traditional plasmas in many ways: these are low-temperature high pressure systems containing nanometer to micrometer size particles which may be highly charged and strongly interacting. The particles may be chemically reacting or be in contact with solid surfaces, and the electrons may show quantum behaviour. These interesting properties have led to many applications of complex plasmas in technology, medicine and science. Yet complex plasmas are extremely complicated, both experimentally and theoretically, and require a variety of new approaches which go beyond standard plasma physics courses. This book fills this gap presenting an introduction to theory, experiment and computer simulation in this field. Based on tutorial lectures at a very successful recent Summer Institute, the presentation is ideally suited for graduate students, plasma physicists and experienced undergraduates.

  15. Extremal Black Hole and Flux Vacua Attractors

    CERN Document Server

    Bellucci, S; Kallosh, R; Marrani, A

    2007-01-01

    These lectures provide a pedagogical, introductory review of the so-called Attractor Mechanism (AM) at work in two different 4-dimensional frameworks: extremal black holes in N=2 supergravity and N=1 flux compactifications. In the first case, AM determines the stabilization of scalars at the black hole event horizon purely in terms of the electric and magnetic charges, whereas in the second context the AM is responsible for the stabilization of the universal axion-dilaton and of the (complex structure) moduli purely in terms of the RR and NSNS fluxes. Two equivalent approaches to AM, namely the so-called ``criticality conditions'' and ``New Attractor'' ones, are analyzed in detail in both frameworks, whose analogies and differences are discussed. Also a stringy analysis of both frameworks (relying on Hodge-decomposition techniques) is performed, respectively considering Type IIB compactified on $CY_{3}$ and its orientifolded version, associated with $\\frac{CY_{3}\\times T^{2}}{\\mathbb{Z}_{2}}$. Finally, recent...

  16. Lower extremity kinetics in tap dance.

    Science.gov (United States)

    Mayers, Lester; Bronner, Shaw; Agraharasamakulam, Sujani; Ojofeitimi, Sheyi

    2010-01-01

    Tap dance is a unique performing art utilizing the lower extremities as percussion instruments. In a previous study these authors reported decreased injury prevalence among tap dancers compared to other dance and sports participants. No biomechanical analyses of tap dance exist to explain this finding. The purpose of the current pilot study was to provide a preliminary overview of normative peak kinetic and kinematic data, based on the hypothesis that tap dance generates relatively low ground reaction forces and joint forces and moments. Six professional tap dancers performed four common tap dance sequences that produced data captured by the use of a force platform and a five-camera motion analysis system. The mean vertical ground reaction force for all sequences was found to be 2.06+/-0.55 BW. Mean peak sagittal, frontal, and transverse plane joint moments (hip, knee, and ankle) ranged from 0.07 to 2.62 N.m/kg. These small ground reaction forces and joint forces and moments support our hypothesis, and may explain the relatively low injury incidence in tap dancers. Nevertheless, the analysis is highly complex, and other factors remain to be studied and clarified.

  17. Sparse extreme learning machine for classification.

    Science.gov (United States)

    Bai, Zuo; Huang, Guang-Bin; Wang, Danwei; Wang, Han; Westover, M Brandon

    2014-10-01

    Extreme learning machine (ELM) was initially proposed for single-hidden-layer feedforward neural networks (SLFNs). In the hidden layer (feature mapping), nodes are randomly generated independently of training data. Furthermore, a unified ELM was proposed, providing a single framework to simplify and unify different learning methods, such as SLFNs, least square support vector machines, proximal support vector machines, and so on. However, the solution of unified ELM is dense, and thus, usually plenty of storage space and testing time are required for large-scale applications. In this paper, a sparse ELM is proposed as an alternative solution for classification, reducing storage space and testing time. In addition, unified ELM obtains the solution by matrix inversion, whose computational complexity is between quadratic and cubic with respect to the training size. It still requires plenty of training time for large-scale problems, even though it is much faster than many other traditional methods. In this paper, an efficient training algorithm is specifically developed for sparse ELM. The quadratic programming problem involved in sparse ELM is divided into a series of smallest possible sub-problems, each of which are solved analytically. Compared with SVM, sparse ELM obtains better generalization performance with much faster training speed. Compared with unified ELM, sparse ELM achieves similar generalization performance for binary classification applications, and when dealing with large-scale binary classification problems, sparse ELM realizes even faster training speed than unified ELM.

  18. Non-resonant Nanoscale Extreme Light Confinement

    Energy Technology Data Exchange (ETDEWEB)

    Subramania, Ganapathi Subramanian [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Huber, Dale L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-09-01

    A wide spectrum of photonics activities Sandia is engaged in such as solid state lighting, photovoltaics, infrared imaging and sensing, quantum sources, rely on nanoscale or ultrasubwavelength light-matter interactions (LMI). The fundamental understanding in confining electromagnetic power and enhancing electric fields into ever smaller volumes is key to creating next generation devices for these programs. The prevailing view is that a resonant interaction (e.g. in microcavities or surface-plasmon polaritions) is necessary to achieve the necessary light confinement for absorption or emission enhancement. Here we propose new paradigm that is non-resonant and therefore broadband and can achieve light confinement and field enhancement in extremely small areas [~(λ/500)^2 ]. The proposal is based on a theoretical work[1] performed at Sandia. The paradigm structure consists of a periodic arrangement of connected small and large rectangular slits etched into a metal film named double-groove (DG) structure. The degree of electric field enhancement and power confinement can be controlled by the geometry of the structure. The key operational principle is attributed to quasistatic response of the metal electrons to the incoming electromagnetic field that enables non-resonant broadband behavior. For this exploratory LDRD we have fabricated some test double groove structures to enable verification of quasistatic electronic response in the mid IR through IR optical spectroscopy. We have addressed some processing challenges in DG structure fabrication to enable future design of complex sensor and detector geometries that can utilize its non-resonant field enhancement capabilities.].

  19. Extreme Ionizing-Radiation-Resistant Bacterium

    Science.gov (United States)

    Vaishampayan, Parag A.; Venkateswaran, Kasthuri J.; Schwendner, Petra

    2013-01-01

    There is a growing concern that desiccation and extreme radiation-resistant, non-spore-forming microorganisms associated with spacecraft surfaces can withstand space environmental conditions and subsequent proliferation on another solar body. Such forward contamination would jeopardize future life detection or sample return technologies. The prime focus of NASA s planetary protection efforts is the development of strategies for inactivating resistance-bearing micro-organisms. Eradi cation techniques can be designed to target resistance-conferring microbial populations by first identifying and understanding their physiologic and biochemical capabilities that confers its elevated tolerance (as is being studied in Deinococcus phoenicis, as a result of this description). Furthermore, hospitals, food, and government agencies frequently use biological indicators to ensure the efficacy of a wide range of radiation-based sterilization processes. Due to their resistance to a variety of perturbations, the nonspore forming D. phoenicis may be a more appropriate biological indicator than those currently in use. The high flux of cosmic rays during space travel and onto the unshielded surface of Mars poses a significant hazard to the survival of microbial life. Thus, radiation-resistant microorganisms are of particular concern that can survive extreme radiation, desiccation, and low temperatures experienced during space travel. Spore-forming bacteria, a common inhabitant of spacecraft assembly facilities, are known to tolerate these extreme conditions. Since the Viking era, spores have been utilized to assess the degree and level of microbiological contamination on spacecraft and their associated spacecraft assembly facilities. Members of the non-sporeforming bacterial community such as Deinococcus radiodurans can survive acute exposures to ionizing radiation (5 kGy), ultraviolet light (1 kJ/m2), and desiccation (years). These resistive phenotypes of Deinococcus enhance the

  20. Analysis of extreme hydrological phenomena in southern Italy (Calabria region)

    Science.gov (United States)

    Caloiero, Tommaso; Aceto, Luigi; Aurora Pasqua, A.; Petrucci, Olga

    2017-04-01

    . Moreover, the SPI is easier to calculate than complex indices, as it is based on precipitation alone, and allows comparing drought conditions among different periods and regions. Both the series have been analysed jointly, in order to obtain the general trend of extreme rain and drought, characterised by mean of descriptive climatic features and damage caused. The results supply a glance in the past climatic history of the region that can be used to project to future and be prepared for ongoing changes related to climate changes. In fact, the identification of the most floods and drought prone areas can be useful for both civil protection mitigation strategies and water resources management (water used for home, industrial, and agricultural purposes).