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Sample records for extreme patch test

  1. Biocide patch tests

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Veien, Niels

    1985-01-01

    Routine patch testing with a series of 6 industrial biocides containing methylene-bis-thiocyanate (Cytox 3522), benzisothiazolin-3-one (BIT), chlorocresol (Preventol CMK), 2-n-octyl-4-isothiazolin-3-one (Kathon 893), polyhydroxymethylene monobenzylether (Preventol D2) or 1,3,5-tris (hydroxy-ethyl...

  2. Patch test with preservatives

    Directory of Open Access Journals (Sweden)

    Kar Sumit

    1992-01-01

    Full Text Available Of the 705 patients patch tested between March 88 to March 91, 317 were tested for sensitivity to preservatives with antigens obtained from Chemo technique AB, Sweden. Paraben was the commonest sensitizer (22.4% followed by Groton B K (8.1% and Triclosan (6.5%. We stress the need to consider these allergens as source of dermatitis and advocate complete labelling of topical preparations marketed.

  3. Patch photopatch test at Manipal

    Directory of Open Access Journals (Sweden)

    Panja Arindrajit

    1994-01-01

    Full Text Available Patch and photopatch testing was performed on 55 patients with history of photosensitivity using Scandanavian photo patch test antigens obtained from Chemotechnique Diagnostics AB Sweden. The commonest reactions were seen to perfume mix 4 (21.0%, PABA 3 (15.78%, promethazine hydrochloride 3 (15.78%, chlorpromazine hydrochloride 3 (15.78%, balsam of peru 2 (10.52%, usnic acid, hexachlorophane, musk ambrette and 6 methyl coumarin showed 1 positive reaction each (5.26% suggesting either phototoxicity or photo sensitization. Patch and photo patch test positive reaction suggesting allergic sensitisation was seen to balsam of peru 3 (23.0% perfume mix 3 (23.0% promethazine hydrochloride 2 (15.3% and PABA, 6 methyl coumarin, tribromosalicylanilide, atranorin and wood mix showed positive reaction in one case each (7.69%. We conclude that photoxic or photo allergic reaction is a problem in India and patch photo patch test should be performed in all cases of idiopathic light eruptions to rule out photo sensitisation and in cases where photo sensitivity of exogenous origin is suspected.

  4. Formaldehyde concentration in diagnostic patch testing

    DEFF Research Database (Denmark)

    Trattner, A; Johansen, J D; Menné, T

    1998-01-01

    Exposure to formaldehyde is common from both consumer products and industry. The reliability of the patch test is essential for the diagnosis of formaldehyde allergy as it is difficult to suspect from the patient's history. The recommended formaldehyde patch test concentration has been reduced over......% in consecutively patch-tested patients, with respect to frequency of positive patch test reactions, strength of patch test reactions to different formaldehyde test concentrations, irritancy and relevance. The study included 3734 consecutively patch tested patients. 121 gave a positive reaction to 1% and/or 2...... gave few additional positive cases compared to D 3/4. Problems related to relevance are discussed. Based on present knowledge, a 1% patch test concentration for formaldehyde is recommended....

  5. Enhanced patch test of finite element methods

    Institute of Scientific and Technical Information of China (English)

    CHEN; Wanji

    2006-01-01

    Theoretically, the constant stress patch test is not rigorous. Also, either the patch test of non-zero constant shear for Mindlin plate problem or non-zero strain gradient curvature of the microstructures cannot be performed. To improve the theory of the patch test, in this paper, based on the variational principle with relaxed continuity requirement of nonconforming element for homogeneous differential equations, the author proposed the individual element condition for passing the patch test and the convergence condition of the element: besides passing the patch test, the element function should include the rigid body modes and constant strain modes and satisfy the weak continuity condition, and no extra zero energy modes occur. Moreover, the author further established a variational principle with relaxed continuity requirement of nonconforming element for inhomogeneous differential equations, the enhanced patch test condition and the individual element condition. To assure the convergence of the element that should pass the enhanced patch test, the element function should include the rigid body modes and non-zero strain modes which satisfied the equilibrium equations, and no spurious zero energy modes occur and should satisfy new weak continuity condition. The theory of the enhanced patch test proposed in this paper can be applied to both homogeneous and inhomogeneous differential equations. Based on this theory, the patch test of the non-zero constant shear stress for Mindlin plate and the C0-1 patch test of the non-zero constant curvature for the couple stress/strain gradient theory were established.

  6. The "edge effect" with patch test materials.

    Science.gov (United States)

    Fyad, A; Masmoudi, M L; Lachapelle, J M

    1987-03-01

    A positive "edge effect", i.e., the accumulation on the skin of a chemical solution (such as fluorescein 0.01% in a 50/50 water-ethanol solution) at the periphery of the patch test sites has been demonstrated. It occurs with different test materials (Finn Chamber; Silver Patch Test; Patch Test Chamber). Practical implications are discussed: this observation could be important when discussing results of laboratory investigations. In clinical practice, it could explain the occurrence of "ring-shaped" positive allergic patch test reactions to chemicals used in solution, i.e., Kathon CG or hydrocortisone.

  7. Patch testing for adverse drug reactions.

    Science.gov (United States)

    Sekhon, Sahil; Nedorost, Susan T

    2017-01-01

    Adverse drug reactions result in a substantial number of hospital admissions and inpatient events. Diagnosis usually is made with clinical judgment and circumstantiality without diagnostic testing. Furthermore, even in situations where diagnostic testing is performed, no safe gold standard tests exist. Oral rechallenge is currently the gold standard but carries the risk of recrudescence of severe allergic symptoms. Other tests include skin prick tests, the lymphocyte transformation test, immunohistochemistry, and patch testing. This article provides a review of patch testing in cases of adverse drug reactions and presents new data on this topic.

  8. Evidence-based diagnosis in patch testing

    NARCIS (Netherlands)

    van der Valk, PGM; Devos, SA; Coenraads, PJ

    2003-01-01

    Evidence-based medicine (EBM) is defined as the integration of the best research evidence with clinical expertise and patient values. Based on the principles of EBM, we can conclude that patch testing is cost-effective only if patients are selected on the basis of a clear-cut clinical suspicion of c

  9. Positive patch test reactions to oxidized limonene

    DEFF Research Database (Denmark)

    Bråred Christensson, Johanna; Andersen, Klaus E; Bruze, Magnus

    2014-01-01

    BACKGROUND: R-Limonene is a common fragrance terpene found in domestic and industrial products. R-Limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3-12.1%) of 2900 patients showed a positive patch test reactio...

  10. A stronger patch test elicitation reaction to the allergen hydroxycitronellal plus the irritant sodium lauryl sulfate

    DEFF Research Database (Denmark)

    Heydorn, S; Andersen, Klaus Ejner; Johansen, Jeanne Duus;

    2003-01-01

    elicitation reaction than patch testing with the allergen (hydroxycitronellal) alone, in patients previously patch tested positive to hydroxycitronellal. A stronger patch test elicitation reaction was defined as at least 1 day of patch test reading showing more positive patch tests...

  11. Patch testing in contact dermatitis of hands and feet

    Directory of Open Access Journals (Sweden)

    Huda M

    1996-01-01

    Full Text Available Eighty clinically diagnosed cases of allergic contact dermatitis of hands and feet when subjected to patch testing, Seventy four (92.5% cases showed positive patch test reactions to different suspected antigens. Maximum number of cases belonged to housewives and tea garden workers which showed positive patch test reaction to vegetables and soaps and detergents and pesticides, respectively.

  12. Retrospective evaluation of the consequence of alleged patch test sensitization

    DEFF Research Database (Denmark)

    Jensen, Charlotte D; Paulsen, Evy; Andersen, Klaus E

    2006-01-01

    consequences in cases of possible patch test sensitization. Among 7619 consecutively tested eczema patients in a 14-year period 26 (0.3%) were identified in the database as having had a late patch test reaction, which may be an indication of patch test sensitization. 9 of these cases were not suitable....... For the remaining 11 patients we could not rule out that they were patch test sensitized, and they were investigated further. 1 was diseased and 10 were interviewed regarding the possible consequences of the alleged patch test sensitization. 9 had not experienced any dermatitis problems, and 1 could not exclude...

  13. Contact Dermatitis, Patch Testing, and Allergen Avoidance.

    Science.gov (United States)

    Burkemper, Nicole M

    2015-01-01

    In patients presenting with a complaint of rash, contact dermatitis is often the underlying diagnosis making it an entity with which health care providers should be familiar. Contact dermatitis can be divided into irritant contact dermatitis and allergic contact dermatitis. In a patient suspected of having allergic contact dermatitis, patch testing can be done to identify specific allergens. Education focused on allergen avoidance and safe products is an integral part of treatment for the contact dermatitis patient. Knowledge of the most common allergens is helpful for clinicians to be able to provide this education.

  14. Patch Testing In Soldiers : An Evaluation

    Directory of Open Access Journals (Sweden)

    Walia N. S

    2004-01-01

    Full Text Available Our study concerns contact sensitization in soldiers, the frequency of which is poorly documented. During a six-year period, 128 patients of age range 17-50 years were patch tested with the Indian standard battery of 30 allergens. We obtained a reaction in 23 (18% of our patients. Nickel sulfate, fragrance mix, wool alcohol and parthenium induced most of the positive responses. In addition, an irritant reaction was seen in 16 (12.5% of our patients. Patients of atopic dermatitis and hand/foot dermatoses evoked a high sensitivity response. Adverse effects were seen in 15 patients.

  15. Patch testing with Indian standard series

    Directory of Open Access Journals (Sweden)

    Narendra G

    2002-01-01

    Full Text Available Hundred patients (61 males, 39 females suspected to have allergic contact dermatitis were patch tested with Indian standard series (ISS. Forty four showed one or more positive reactions. The frequent sensitizers observed were nickel sulphate-12 (15%, potassium dichromate-11 (13.75%, cobalt chloride and colophony-7 (8.75% each, fragrance mix and thiuram mix-6 (7.5% each. The ISS differs from the European Standard Series by inclusion of propylene glycol, nitrofurazone, gentamicin, chlorocresol, PEG-400 and ethylenediamine chloride where assesquiterpene lactone mix and primin allergens are excluded.

  16. A Pragmatic Approach to Patch Testing Atopic Dermatitis Patients

    DEFF Research Database (Denmark)

    Chen, Jennifer K; Jacob, Sharon E; Nedorost, Susan T

    2016-01-01

    Allergic contact dermatitis (ACD) may complicate the clinical course of atopic dermatitis (AD), and patch testing remains the criterion standard for diagnosing ACD. To date, there have been no guidelines or consensus recommendations on when and how to patch test individuals with AD. Failure...... to patch test when appropriate may result in overlooking an important and potentially curable complicating comorbidity. In this article, we present consensus recommendations regarding when to perform patch testing in the AD patient, best practices, and common pitfalls. Patch testing should be considered...

  17. Cost benefit of patch testing with textile finish resins

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Hamann, K

    1982-01-01

    Eleven years experience of textile finish resin patch testing of suspected textile dermatitis patients revealed 15 cases of allergic textile dermatitis among 428 patients tested. Ten of the 15 patients had a relevant positive patch test to one or more of a limited series of textile finishes; 1...... was negative and 4 were not tested with textile finishes. All 15 patients were formaldehyde sensitive. No unexpected, relevant, positive textile finish resin patch test was found. In this study a negative patch test to formaldehyde virtually excluded allergic contact dermatitis from textile finishes....

  18. Histological distinction between early allergic and irritant patch test reactions

    DEFF Research Database (Denmark)

    Vestergaard, L; Clemmensen, Ole; Sørensen, Flemming Brandt

    1999-01-01

    differentiate between early allergic and irritant patch test reactions. 8 patients with known contact allergy to either colophony or quarternium-15 participated in the study. In each patient, allergic and irritant patch tests reactions were elicited, and 4-mm punch biopsies were taken after 6 8 h from...... clinically equipotent reactions. Paired sets of slides were assessed blindly by 2 pathologists. 1 patient showing a pityrosporum folliculitis was excluded from the study. All biopsies from allergic patch tests were characterized by follicular spongiosis, while biopsies from irritant patch tests showed...... the diagnostic significance of the histological classification of allergic and irritant cutaneous reactions in punch biopsies....

  19. Nickel patch test reactivity and the menstrual cycle

    DEFF Research Database (Denmark)

    Rohold, A E; Halkier-Sørensen, L; Thestrup-Pedersen, K;

    1994-01-01

    Premenstrual exacerbation of allergic contact dermatitis and varying allergic patch test responses have been reported at different points of the period. Using a dilution series of nickel sulphate, we studied the variation in patch test reactivity in nickel allergic women in relation...... to the menstrual cycle. Twenty women with regular periods were tested on day 7-10 and on day 20-24. Ten nickel patch tests with different concentrations were applied using the TRUE test assay, and the threshold concentration of nickel sulphate eliciting an erythematous reaction was determined. Half of the women...... an increased nickel sensitivity at the second patch test (0.02 nickel sulphate patch tests premenstrually in 20 nickel allergic women, but we found that elicitation...

  20. Trends and developments in two decades of patch testing

    NARCIS (Netherlands)

    Christoffers, W.A.; Schuttelaar, M.-L.A.; Coenraads, P.J.

    2013-01-01

    Introduction: Allergic contact dermatitis is a common condition with an estimated lifetime prevalence of 19.5%. The diagnosis is confirmed by patch tests. This study aims to visualise trends and developments in patch testing over 23 years and to evaluate the influence of legal restrictions with spec

  1. Dermatotoxicologic clinical solutions: textile dye dermatitis patch testing.

    Science.gov (United States)

    Coman, Garrett; Blickenstaff, Nicholas; Edwards, Ashley; Maibach, Howard

    2015-03-01

    The authors provide a framework for working up and counseling a patient with suspected textile dermatitis, focusing on identifying which textile materials are most likely to be the cause of the eczematous lesions, the current clinical guidelines, the utility and appropriateness of patch testing, the limitations of these guidelines, and our pro tempore recommendations. While there are many challenges to correctly identify and counsel patients on how to avoid the offending textile products in a patient with suspected textile dye dermatitis, there is value in following the guidelines set forth to help identify the causative textile(s). Although patch tests can be useful, dermatologists should understand the limitations of standardized patch testing for patients with suspected textile dye-induced dermatitis. These guidelines are expected to increase the likelihood of identifying the causative textile(s), so that patch testing can be supplemented with swatch testing and chemical dye extraction to help discover the allergenic dye.

  2. Unusual edge effect in patch testing with silver nitrate.

    Science.gov (United States)

    Iliev, D; Elsner, P

    1998-03-01

    Silver nitrate is a widely used substance and has been applied topically for cauterizing bleeding and healing wounds. In the past it has even been used to mark patch test sites, when no one knew that the substance itself might be a sensitizer. However, there are also toxic reactions to that substance. We report a case in which a positive "edge effect" at the periphery of the patch test site could be shown. It can be explained by the unequal distribution of patch test solutions in the different patch test systems with a concentration at the rim. Distinguishing between allergic and toxic reactions may be difficult when an edge effect occurs. Therefore, in certain rare cases a biopsy or a lymphocyte transformation test might be of help.

  3. Histological distinction between early allergic and irritant patch test reactions

    DEFF Research Database (Denmark)

    Vestergaard, L; Clemmensen, Ole; Sørensen, Flemming Brandt

    1999-01-01

    Comparative light microscopic studies have revealed subtle differences between allergic and irritant reactions in the skin. In the search for specific differences, we focussed on the early inflammatory response. This pilot study was conducted to test the hypothesis that follicular spongiosis can...... differentiate between early allergic and irritant patch test reactions. 8 patients with known contact allergy to either colophony or quarternium-15 participated in the study. In each patient, allergic and irritant patch tests reactions were elicited, and 4-mm punch biopsies were taken after 6 8 h from...... clinically equipotent reactions. Paired sets of slides were assessed blindly by 2 pathologists. 1 patient showing a pityrosporum folliculitis was excluded from the study. All biopsies from allergic patch tests were characterized by follicular spongiosis, while biopsies from irritant patch tests showed...

  4. Okeanos Explorer (EX1601): Transit and Mission Patch Test

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Normal underway operations and mapping patch testing. Bathymetric mapping of either the Murray or Molokai Fracture Zones during the transit to Hawaii is planned, as...

  5. Investigation of the homogeneity of methacrylate allergens in commercially available patch test preparations

    DEFF Research Database (Denmark)

    Mose, Kristian Fredløv; Andersen, Klaus Ejner; Christensen, Lars Porskjaer

    2013-01-01

    The homogeneity of methacrylates in commercial patch test preparations has not yet been investigated. Inhomogeneous patch test preparations may give rise to false-negative or false-positive patch test results in patients suspected of having methacrylate allergy....

  6. Low patch test reactivity to nickel in unselected adolescents tested repeatedly with nickel in infancy

    DEFF Research Database (Denmark)

    Christiansen, Elisabeth Soegaard; Andersen, Klaus Ejner; Bindslev-Jensen, Carsten

    2016-01-01

    BACKGROUND: It is questionable how repeated patch tests with nickel sulphate in infancy affect nickel patch test reactivity at a later age. METHODS: The DARC cohort encompasses 562 infants invited to a clinical examination including patch tests with nickel sulphate 6 times during the first 36 mon...

  7. Aeroallergen patch testing in patients of suspected contact dermatitis

    Directory of Open Access Journals (Sweden)

    Nelee Bisen

    2014-01-01

    Full Text Available Background: Aeroallergens are airborne substances present in the environment with the potential to trigger an allergic reaction in the respiratory tract, mucosae, or skin of susceptible individuals. The relevance of aeroallergens in the pathogenesis of atopic dermatitis has been reported by many investigators. However, very few studies have been conducted to investigate their role in the production of allergic contact dermatitis (ACD. Aims: To determine the prevalence of aeroallergen patch test positivity in patients of suspected ACD and to study the clinical characteristics of patients testing positive with aeroallergens. Materials and Methods: Patients presenting to our department with suspected contact allergy and undergoing patch testing with Indian Standard Series (ISS between January 2010 and June 2011 were studied. After a detailed history and clinical examination, patients were patch tested with ISS and aeroallergen series. Based on the history and clinical suspicion, patients were additionally patch tested with 15% Parthenium. Prior tape stripping was done in some patients. Results: Out of total 114 patients, 26 (22.8% showed sensitivity to aeroallergen series. Parthenium was the commonest aeroallergen being positive in all 26 patients followed by Xanthium in two. None reacted to other allergens. Although positivity was more in patients with prior tape stripping, the difference was not statistically significant. Conclusion: Most common aeroallergen found to be positive in our study was Parthenium hysterophorus. In view of low positivity to other allergens, routine aeroallergen patch testing in patients with suspected contact dermatitis may not be necessary.

  8. Fixed drug eruption by etoricoxib confirmed by patch test*

    Science.gov (United States)

    de Sousa, Aline Soares; Cardoso, José Carlos; Gouveia, Miguel Pinto; Gameiro, Ana Rita; Teixeira, Vera Barreto; Gonçalo, Maria

    2016-01-01

    Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib. Lesional patch testing with etoricoxib was positive and reproduced the typical pattern of a fixed drug eruption upon histopathology. We emphasize the specific reactivity of the etoricoxib patch test, and the capacity to reproduce the histologic pattern of the reaction. PMID:27828643

  9. Photopatch and UV-irradiated patch testing in photosensitive dermatitis

    Directory of Open Access Journals (Sweden)

    Reena Rai

    2016-01-01

    Full Text Available Background: The photopatch test is used to detect photoallergic reactions to various antigens such as sunscreens and drugs. Photosensitive dermatitis can be caused due to antigens like parthenium, fragrances, rubbers and metals. The photopatch test does not contain these antigens. Therefore, the Indian Standard Series (ISS along with the Standard photopatch series from Chemotechnique Diagnostics, Sweden was used to detect light induced antigens. Aim: To detect light induced antigens in patients with photosensitive dermatitis. Methods: This study was done in a descriptive, observer blinded manner. Photopatch test and ISS were applied in duplicate on the patient's back by the standard method. After 24 hours, readings were recorded according to ICDRG criteria. One side was closed and other side irradiated with 14 J/cm2 of UVA and a second set of readings were recorded after 48 hrs. Result: The highest positivity was obtained with parthenium, with 18 out of 35 (51% patients showing a positive patch test reaction with both photoallergic contact dermatitis and photoaggravation. Four patients (11% showed positive patch test reaction suggestive of contact dermatitis to potassium dichromate and fragrance mix. Six patients had contact dermatitis to numerous antigens such as nickel, cobalt, chinoform and para-phenylenediamine. None of these patients showed photoaggravation on patch testing. Conclusion: Parthenium was found to cause photoallergy, contact dermatitis with photoaggravation and contact allergy. Hence, photopatch test and UV irradiated patch test can be an important tool to detect light induced antigens in patients with photosensitive dermatitis.

  10. Patch testing with corticosteroid mixes in Europe

    DEFF Research Database (Denmark)

    Isaksson, M; Andersen, Klaus Ejner; Brandão, F M

    2000-01-01

    , each at 2 concentrations, were inserted into the standard series of 16 participating clinics. Tests were read on day (D) 3 or 4. 5432 patients were tested, and 110 (2.0%) had positive reactions to at least 1 of the 8 test preparations. Of the 8 preparations, mix I identified most allergic patients...... to 1.0% and another 25% only to 0.10%. Testing with mix I and tixocortol pivalate 0.10% picked up 98/110, testing with tixocortol pivalate 1.0% and 0.10% and budesonide 0.10% picked up 105/110. 3379 patients were read on both D3 or D4 as well as on D7. Without a late reading (D7), up to 30% of contact...

  11. Investigation of contact allergy to dental materials by patch testing

    Directory of Open Access Journals (Sweden)

    Reena Rai

    2014-01-01

    Full Text Available Background: Dental products are widely used by patients and dental personnel alike and may cause problems for both. Dental materials could cause contact allergy with varying manifestations such as burning, pain, stomatitis, cheilitis, ulcers, lichenoid reactions localized to the oral mucosa in patients, and hand dermatitis in dental personnel. Patch testing with the dental series comprising commonly used materials can be used to detect contact allergies to dental materials. Aim: This study aimed to identify contact allergy among patients who have oral mucosal lesions after dental treatment and among dental personnel who came in contact with these materials. Materials and Methods: Twenty patients who had undergone dental procedures with symptoms of oral lichen planus, oral stomatitis, burning mouth, and recurrent aphthosis, were included in the study. Dental personnel with history of hand dermatitis were also included in the study. Patch testing was performed using Chemotechnique Dental Series and results interpreted as recommended by the International Contact Dermatitis Research Group (ICDRG. Results: Out of 13 patients who had undergone dental treatment/with oral symptoms, six patients with stomatitis, lichenoid lesions, and oral ulcers showed positive patch tests to a variety of dental materials, seven patients with ulcers had negative patch tests, seven dental personnel with hand dermatitis showed multiple allergies to various dental materials, and most had multiple positivities. Conclusion: The patch test is a useful, simple, noninvasive method to detect contact allergies among patients and among dental personnel dealing with these products. Long term studies are necessary to establish the relevance of these positive patch tests by eliminating the allergic substances, identifying clinical improvement, and substituting with nonallergenic materials.

  12. Patch test dose-response study of p-phenylenediamine

    DEFF Research Database (Denmark)

    Sosted, Heidi; Menné, Torkil; Johansen, Jeanne Duus

    2006-01-01

    The elicitation response in allergic contact dermatitis for the hair dye substance p-phenylenediamine (PPD) is dose dependent, but threshold concentrations have not previously been investigated. 15 PPD-sensitive patients participated in a serial dilution 48-hr patch test with PPD using 8 concentr...

  13. Patch testing for food-associated allergies in orofacial granulomatosis.

    LENUS (Irish Health Repository)

    Fitzpatrick, Laura

    2011-01-01

    Food-associated allergies, especially to benzoates and cinnamon-related compounds, have been associated with orofacial granulomatosis and both standard and urticarial patch testing have been used to detect such allergies. Elimination diets have also been shown to be effective in some patients.

  14. Patch Test Results of 775 Patients with Allergic Contact Dermatitis

    Directory of Open Access Journals (Sweden)

    Simin Ada

    2010-12-01

    Full Text Available Background and Design: The allergens responsible for allergic contact dermatitis vary among countries and even between different geographical regions within the same country over time. It is of great importance to perform the patch test at certain intervals, to evaluate the results in different centers and to compare them afterwards. Our aim was to evaluate the patch test results in our patients with allergic contact dermatitis.Material and Method: The records of the patients with allergic contact dermatitis, who had been patch tested between May 1997 and March 2009, were analyzed retrospectively. The demographic features such as age and sex, localization of the contact dermatitis, and the patch test results were recorded. Results: Of the 775 patients, 581 (75.2% were females and 194 (25% males. Of all patients, 735 were patch tested with the European Standard Series, 318 - with both the European Standard Series and cosmetic series, and 40-with cosmetic series alone. Of the patients tested with the European Standard Series, 255 (34.7% had at least one positive reaction. The most frequent allergen in the European Standard Series was nickel sulfate (17.3%, followed by cobalt chloride (7.2%, potassium dichromate (3%, fragrance mix (2.9%, and p-phenylenediamine base (2.6%. Of the 358 patients tested with cosmetic series, 82 (22.9% had at least one positive reaction. The 5 most frequently observed cosmetic series allergens were octyl gallate (3.9%, thimerosal (2.2%, sorbitan sesquioleate (2%, Euxyl K 400 (2% and methyldibromo glutaronitrile (1.4%. Conclusion: Our study shows the contact allergen profile of our center over 12 years. The most common allergens and their frequency differ between centers in various cities in Turkey. Those geographical differences should be re-evaluated by further studies performed in the certain time period. The high frequency of reactions to octyl gallate is an important finding in patients suspected of cosmetic allergy

  15. Impulse Testing of Corporate-Fed Patch Array Antennas

    Science.gov (United States)

    Chamberlain, Neil F.

    2011-01-01

    This paper discusses a novel method for detecting faults in antenna arrays. The method, termed Impulse Testing, was developed for corporate-fed patch arrays where the element is fed by a probe and is shorted at its center. Impulse Testing was devised to supplement conventional microwave measurements in order to quickly verify antenna integrity. The technique relies on exciting each antenna element in turn with a fast pulse (or impulse) that propagates through the feed network to the output port of the antenna. The resulting impulse response is characteristic of the path through the feed network. Using an oscilloscope, a simple amplitude measurement can be made to detect faults. A circuit model of the antenna elements and feed network was constructed to assess various fault scenarios and determine fault-detection thresholds. The experimental setup and impulse measurements for two patch array antennas are presented. Advantages and limitations of the technique are discussed along with applications to other antenna array topologies

  16. Patch test with ether extracts in salicaceae allergy

    Directory of Open Access Journals (Sweden)

    Sawhney M

    2002-01-01

    Full Text Available A total of 23 cases suggestive of airborne contact dermatitis were patch tested with ether extracts of flowers and leaves of populus sp. and salix sp. in a study conducted in Ladakh at an altitude of 3445 meters above sea level. Overall positivity was found in 12 (52.17%, with populus sp. alone in 7 (30. 43%, salix sp. alone in 4 17.39% and to both in one (8.33%.

  17. DIAGNOSTIC VALUE OF PATCH TEST IN HAND AND FOOT ECZEMAS

    Directory of Open Access Journals (Sweden)

    Sravani Sandhya Bellam

    2016-11-01

    Full Text Available BACKGROUND The present study is undertaken to evaluate the results of patch test in 50 patients having hand and foot eczema attending skin OPD from October 2010 to September 2012 at KIMS, Narketpally. RESULTS Maximum number of cases in this study belong to 16-30 yrs. (46%.  In majority of cases, eczema was seen in both hands and feet (40%. Hand and foot eczema was commonly seen in construction workers (42.3%.  Mean duration of illness is 19.48 months.  42% of patients presented with acute eczema followed by subacute eczema (38% and then chronic eczema (20%.  Personal and family history of atopy was seen in only 4% and 6%, respectively.  Hand and foot eczema (42.3% was the commonest eczema followed by hand (30.74% and then foot eczema (11.53% and others (15.37%.  57.69% of patients are positive to more than one allergen and 42.3% were positive to single allergen.  Multiple allergens positivity is seen in construction workers (30.76%.  Potassium di chromate (28.5% is the common allergen found in patch test followed by Parthenium (16.6% followed by Paraphenylenediamine (14% and then Cobalt sulphate and Thiuram mix (9.5% and lastly Parabens mix, Nickel sulphate, Black rubber mix and Neomycin (4.7%.  Positive patch test is more commonly observed in patients having hands and or foot eczemas (42.30%. CONCLUSION Hand and foot eczema (42% was the commonest eczema followed by hand (30% and then foot eczema (11.5% and others (15.3%. Potassium dichromate is the commonest sensitiser (28.8%. We encountered a high degree of patch test positivity in our study group and the Indian standard series proved to be very useful.

  18. Patch Test Results in Patients with Allergic Contact Dermatitis / Mucositis

    Directory of Open Access Journals (Sweden)

    Özlem Su

    2008-05-01

    Full Text Available Background and Design: The aims of our study were to determine the frequency of positive patch reactions and the most common allergens in patients with allergic contact dermatitis (ACD and/or mucositis(M who underwent with T.R.U.E. “Thin-layer Rapid-Use Epicutaneous” test and evaluate supplemantal series used with T.R.U.E. test effect on patch test results.Material and Method: In this study 161 ACD, 5 ACM, 1 ACD and ACM were enrolled. While 139 of all patients were patch tested with T.R.U.E. test alone,out of 28 patients were tested for T.R.U.E. test and also with supplemental series that included textile colours (9 of tested patients, plastic and glues (9, dental screening (6, backery (2, cosmetic (1 and plastic and glues and dental screening (1. Supplemental series were chosen according to patient’s occupation and clinic presentation. The data from our patients were analyzed as percentage. The relationship between contact sensitization and atopic status was evaluated with Yate’s correlation x2 test.Results: Eighty-six male, 81 female were taken into this study. The median age was 36.5.While 25.9% of 139 patients tested with T.R.U.E. test alone,46.4% of 28 patients applied supplemental series in addition to T.R.U.E. test showed positive reaction to one or more allergens. The most common allergens were nickel sulphate (14.4%, potassium dichromate (4.8%, fragrance mix (2.9% and colophony (2.9%. The most common supplemental allergens were octil gallat (50% in bakery and copper sulphate, goldsodiumthiosulphate (42.8% in dental screening. Positive patch reactions were detected 83.3% in 6 patients with AKM, 80% of these positive reactions was againts dental screening. The rate of contact sensitization between atopics and non-atopics was not significant (p>0.05. Conclusion: We suggest in presence of mucositis and/or occupational dermatoses using supplemental series in addition to T.R.U.E. test would be more beneficial in identifing the

  19. Patch Test as a Diagnostic Tool in Hand Eczema

    Science.gov (United States)

    Vigneshkarthik, Natarajan; Kuruvila, Sheela

    2016-01-01

    Introduction Allergic contact dermatitis is an important cause of hand eczema. Patch testing is the only investigation available to prove the diagnosis of allergic contact dermatitis. Exposures to allergens differ according to geographical, occupational, economic and social factors. Accordingly, patterns of allergic contact dermatitis differ in different parts of the world and different regions of the same country. Aim To study the causes of allergic contact dermatitis in adult patients with hand eczema with the help of patch testing. Materials and Methods This was a cross-sectional study involving 54 hand eczema patients conducted between October 2013 and June 2015, at a tertiary care centre in Southern India. After a detailed history including history of occupational exposure and detailed examination, patch test was done on these patients with Indian standard series. The patches were removed after 48 hours. Another reading was taken after 72 hours. The readings were interpreted according to International Contact Dermatitis Research Group criteria and noted down. The data were summarized using mean and standard deviation for continuous variables and percentages for categorical and dichotomous variables. The test of association was done with Fisher’s-exact test. Results Hyperkeratotic hand eczema was the commonest morphological type (29%), followed by discoid eczema. Pompholyx was significantly more common among patients with history of atopy. A total of 20 patients (37%) showed patch test positivity to a total of 25 allergens. Nickel was the most common allergen (11.11%) followed by para-phenylenediamine (PPD) (7.4%). Nickel (6 patients) and cobalt (3 patients) were the common allergens among women, while potassium dichromate (3 patients) and parthenium (2 patients) were the common allergens among men. Potassium dichromate allergy was significantly more common among masons and PPD allergy was significantly more common among hair dye users. Discoid pattern of

  20. Prevalence of benzocaine and lidocaine patch test sensitivity in Denmark: temporal trends and relevance

    DEFF Research Database (Denmark)

    Thyssen, Jacob P; Engkilde, Kåre; Menné, Torkil;

    2011-01-01

    BACKGROUND. Allergens included in the European baseline series should result in positive patch test reactions in at least 1% of a patch test population. Inclusion of local anaesthetics other than benzocaine in the baseline series has previously been debated.......BACKGROUND. Allergens included in the European baseline series should result in positive patch test reactions in at least 1% of a patch test population. Inclusion of local anaesthetics other than benzocaine in the baseline series has previously been debated....

  1. Patch testing in Iranian patients: A ten-year experience

    Directory of Open Access Journals (Sweden)

    Davoudi Masoud

    2006-01-01

    Full Text Available Background: Allergic contact dermatitis is a common inflammatory skin disease, which may occur as a result of exposure to specific allergens. Genetic and allergen exposure variations are determinants of different frequency of sensitization in different countries. The objective of this study was to determine the frequency of sensitization to contact allergens in the Iranian patients with dermatitis. Materials and Methods: We analyzed our patch-test database in a referral skin clinic in Tehran, Iran, retrospectively. All patients patch-testing with a clinical diagnosis of contact dermatitis and/or atopic dermatitis over a 10-year period (1993 to 2002 were included. The 23-allergen European standard series (ESS screening has been used for evaluation in all the patients. Results: Data were available from a total of 222 patients. Out of them, 145 patients (65.3% showed at least one positive reaction and 34 patients (15.3% had more than two positive reactions. The five most common allergens were: nickel sulfate 50 (22.6%, cobalt chloride chloride 32 (14.5%, fragrance mix 30 (13.6%, potassium dichromate 21 (9.5% and neomycin sulfate 20 (9.0%. Contact allergy to nickel sulfate was significantly more common in females and in younger patients ( P < 0.05. Fragrance mix was the most common allergen in male patients, but there was no significant difference in its frequency between males and females. Conclusion: The ESS seems to be suitable for patch testing patients in Iran. Nickel sulfate was found to be the most common contact allergen in Iran, mostly affecting women and younger patients probably due to more exposure.

  2. Reactivity to patch tests with nickel sulfate and fragrance mix in infants

    DEFF Research Database (Denmark)

    Jøhnke, H; Norberg, L A; Vach, W

    2004-01-01

    The pattern of patch test reactivity to nickel sulfate and fragrance mix was studied with respect to patch test performance, reproducibility and clinical relevance in a population of unselected infants followed prospectively from birth to 18 months of age. TRUE Testtrade mark patches with nickel ...

  3. Nevirapine patch testing in Thai human immunodeficiency virus infected patients with nevirapine drug hypersensitivity.

    Science.gov (United States)

    Prasertvit, Piyatida; Chareonyingwattana, Angkana; Wattanakrai, Penpun

    2017-08-06

    Antiretroviral drug hypersensitivity in HIV patients is common. Publications have shown that Abacavir (ABC) patch testing is useful in confirming ABC hypersensitivity in 24-50% of cases with a 100% sensitivity of HLA-B*5701 in patch test positive cases. However, Nevirapine (NVP) patch testing has not been reported. (1) To evaluate the usefulness and safety of NVP patch testing in Thai HIV patients with NVP hypersensitivity. (2) To assess the correlation of positive patch tests with HLA-B*3505. Patients were classified into two groups: (1) study group of 20 HIV NVP hypersensitivity patients and (2) control group of 15 volunteers without NVP hypersensitivity. Both groups were patch tested with purified and commercialized form of NVP in various vehicles. Two HIV patients with NVP hypersensitivity were patch test positive. All controls tested negative. Three HIV patients were positive for HLA-B*3505 and the two patients with positive patch testing were both HLA-B*3505 positive. NVP patch testing in Thai HIV patients is safe and can be used to help confirm the association between NVP and hypersensitivity skin reactions. NVP patch test results significantly correlated with HLA-B*3505. The sensitivity of HLA-B*3505 for positive patch test was 100%. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  4. Quantitative relationships between patch test reactivity and use test reactivity: an overview.

    Science.gov (United States)

    Zaghi, Danny; Maibach, Howard I

    2008-01-01

    Use tests such as the provocative use test (PUT) or repeated open application test (ROAT) have been created to better understand the clinical significance of patch test results. It has been suggested that since these tests typically utilize only one substance at a time and avoid occlusion, they minimize the occurrence of irritation and false positives and, thus, are more reflective of real-life exposure to an allergen. In this analysis, we compare and analyze different studies comparing patch test and use test reactivity. With regard to colophony, cinnamic aldehyde, methyldibromo glutaronitrile, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, and isoeugenol, increased patch test sensitivity resulted in increased use test sensitivity. However, this was not true for formaldehyde or chromium. The reason for the latter allergens' divergence from the trend is not yet understood. Additionally, we note the presence of an increasing slope in the relationship between use test reactivity and minimum eliciting concentration on patch testing for methyldibromo glutaronitrile. Expansion of databases relating serial dilution patch test reactivity and use test data should aid dermatologic management, public health policy, and an understanding of the complexity of allergic contact dermatitis in humans.

  5. The effect of patch testing on surgical practices and outcomes in orthopedic patients with metal implants.

    Science.gov (United States)

    Atanaskova Mesinkovska, Natasha; Tellez, Alejandra; Molina, Luciana; Honari, Golara; Sood, Apra; Barsoum, Wael; Taylor, James S

    2012-06-01

    To determine the effect of patch testing on surgical decision making and outcomes in patients evaluated for suspected metal hypersensitivity related to implants in bones or joints. Medical chart review. Tertiary care academic medical center. All patients who had patch testing for allergic contact dermatitis related to orthopedic implants. Patch testing. The surgeon's preoperative choice of metal implant alloy compared with patch testing results and the presence of hypersensitivity complications related to the metal implant on postsurgical follow-up. Patients with potential metal hypersensitivity from implanted devices (N = 72) were divided into 2 groups depending on timing of their patch testing: preimplantation (n = 31) and postimplantation (n = 41). History of hypersensitivity to metals was a predictor of positive patch test results to metals in both groups. Positive patch test results indicating metal hypersensitivity influenced the decision-making process of the referring surgeon in all preimplantation cases (n = 21). Patients with metal hypersensitivity who received an allergen-free implant had surgical outcomes free of hypersensitivity complications (n = 21). In patients who had positive patch test results to a metal in their implant after implantation, removal of the device led to resolution of associated symptoms (6 of 10 patients). The findings of this study support a role for patch testing in patients with a clinical history of metal hypersensitivity before prosthetic device implantation. The decision on whether to remove an implanted device after positive patch test results should be made on a case-by-case basis, as decided by the surgeon and patient.

  6. Contact allergy to popular perfumes; assessed by patch test, use test and chemical analysis

    DEFF Research Database (Denmark)

    Johansen, J D; Rastogi, Suresh Chandra; Menné, T

    1996-01-01

    The frequency of contact allergy to the 10 best-selling women's perfumes was studied in 335 consecutive female eczema patients by patch testing. The diagnostic ability of the fragrance mix, in relation to these products, was evaluated. Of eczema patients, 6.9% had a positive patch test to one...... or more of the perfumes, and 56.5% of these had a concurrent positive reaction to the fragrance mix. Hence, testing with the patients' own cosmetics is a significant part of diagnosing perfume allergy. The clinical relevance of the patch-test reactions to the commercial perfumes was equal...... to that of the fragrance mix, as judged from the patient's history and use testing with one of the perfumes. At least three of the chemically defined sensitizers in the fragrance mix were detected in all the perfumes by gas chromatography-mass spectrometry, which indicates that the fragrance mix is a good imitation...

  7. Allergic contact dermatitis to benzocaine: the importance of concomitant positive patch test results.

    Science.gov (United States)

    González-Rodríguez, A J; Gutiérrez-Paredes, E M; Revert Fernández, Á; Jordá-Cuevas, E

    2013-03-01

    Local anesthetics are widely used in clinical practice, and adverse effects are not uncommon. Delayed hypersensitivity reactions are among the most common effects, but immediate-type reactions may also occur. Patch testing should be considered in patients with hypersensitivity reactions. We present a case of allergic contact dermatitis to benzocaine that was detected incidentally by patch testing and highlight the importance of correctly interpreting patch test results when there are concomitant positive reactions.

  8. Patch test function for axisymmetric element of conventional and couple stress theory

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    The enhanced patch test proposed by Chen W J(2006) can be used to assess the convergence of the problem with non-homogeneous differential equations.Based on this theory,we establish the patch test function for axisymmetric elements of conventional and couple stress theories,and reach an important conclusion that the patch test function for axisymmetric elements cannot contain non-zero constant shear.

  9. Patch test function for axisymmetric element of conventional and couple stress theory

    Institute of Scientific and Technical Information of China (English)

    CHEN WanJi; ZHAO Jie; WANG JinZhi; JI Bian

    2009-01-01

    The enhanced patch test proposed by Chen W J (2006) can be used to assess the convergence of the problem with non-homogeneous differential equations. Based on this theory, we establish the patch test function for axisyrnrnetric elements of conventional and couple stress theories, and reach an im-portant conclusion that the patch test function for axisymrnetric elements cannot contain non-zero constant shear.

  10. Methyldibromoglutaronitrile allergy: relationship between patch test and repeated open application test thresholds

    DEFF Research Database (Denmark)

    Fischer, L.A.; Johansen, J.D.; Menne, T.

    2008-01-01

    a significant relationship between the patch test and the repeated open application test (ROAT) reactivity. Objectives To study the relationship between elicitation threshold doses at single occluded exposure and repeated open application, using MDBGN as the allergen. Methods Eighteen subjects allergic to MDBGN...

  11. Mechanical Development of a Very Non-Standard Patch Array Antenna for Extreme Environments

    Science.gov (United States)

    Hughes, Richard; Chamberlain, Neil; Jakoboski, Julie; Petkov, Mihail

    2012-01-01

    This paper describes the mechanical development of patch antenna arrays for the Juno mission. The patch arrays are part of a six-frequency microwave radiometer instrument that will be used to measure thermal emissions from Jupiter. The very harsh environmental conditions in Jupiter orbit, as well as a demanding launch environment, resulted in a design that departs radically from conventional printed circuit patch antennas. The paper discusses the development and qualification of the Juno patch array antennas, with emphasis on the materials approach that was devised to mitigate the effects of electron charging in Jupiter orbit.

  12. Relationship between formaldehyde and quaternium-15 contact allergy. Influence of strength of patch test reactions

    NARCIS (Netherlands)

    de Groot, Anton C.; Blok, Janine; Coenraads, Pieter-Jan

    2010-01-01

    Objectives: To test our hypothesis that patients with stronger patch test reactions to formaldehyde are more likely to react to quaternium-15, attesting to the aetiological role for formaldehyde in such co-reactivity. Methods: Retrospective analysis of all patients patch tested with formaldehyde and

  13. Quantitative aspects of isoeugenol contact allergy assessed by use and patch tests

    DEFF Research Database (Denmark)

    Johansen, J D; Andersen, Klaus Ejner; Menné, T

    1996-01-01

    The clinical implications of sensitization to the fragrance material isoeugenol were studied in 19 subjects. Patch testing with serial dilutions of isoeugenol and a repeated open application test (ROAT) were performed. The minimum effect level under patch test conditions was below 0.01% isoeugeno...

  14. Repeated patch testing to nickel during childhood do not induce nickel sensitization

    DEFF Research Database (Denmark)

    Søgaard Christiansen, Elisabeth

    2014-01-01

    Background: Previously, patch test reactivity to nickel sulphate in a cohort of unselected infants tested repeatedly at 3-72 months of age has been reported. A reproducible positive reaction at 12 and 18 months was selected as a sign of nickel sensitivity, provided a patch test with an empty Finn...... chamber was negative. The objective of this study is to follow-up on infants with suspected nickel sensitivity. Methods: A total of 562 infants were included in the cohort and patch tested with nickel sulphate. The 26 children with a positive patch test to nickel sulphate at 12 and 18 months were offered...... repeated patch test to nickel sulphate at 3 (36 months), 6 (72 months) and 14 years of age. Results: At 3 years, 24 of 26 nickel sensitive children were retested and a positive reaction was seen in 7 children, a negative reaction in 16 and 1 child was excluded due to reaction to both nickel and the empty...

  15. C~0 and C~1 theories and test functions for FEM patch test in microstructures

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    Among many theories and categories in microstructures,rotation-displacement used as "independent" or "dependent" variables,is a noticeable topic. In FEM,it is called C0 and C1 theory. The convergence criteria of finite elements for microstructures are less mature than those for the conventional thin plate bending problem. In this paper,the patch test functions for assessing convergence of the C0 and C1 finite elements in microstructures is established based on the enhanced patch test theory. The author has further explored the C0 and C1 finite element theories and investigated the difference and correlation between their finite element formulations. Newly proposed finite element theories for microstructures are as follows:(1) the displacement-rotation dependent C1 element that requires the element function satisfying both C0 and C1 continuity;(2) the displacement-rotation independent C0 element which requires new convergence criteria,such as non-zero constant shear stress patch test and zero constant shear stress patch test for approximating C1 element.

  16. Patch testing with a textile dye mix – a multicentre study

    DEFF Research Database (Denmark)

    Ryberg, Kristina; Agner, Tove; Andersen, Klaus E;

    2014-01-01

    BACKGROUND: Disperse dyes are well-known contact sensitizers. However, they are not included in the majority of commercially available baseline patch test series. OBJECTIVES: To investigate the outcome of patch testing with a textile dye mix (TDM) consisting of eight disperse dyes at dermatology ...

  17. Sensitivity, specificity and positive predictive value of patch testing : the more you test, the more you get?

    NARCIS (Netherlands)

    Diepgen, TL; Coenraads, PJ

    2000-01-01

    Pathophysiological variability affects the results of patch testing. In addition, even a minimal degree of test-imprecision due to this variability has a number of important statistical consequences for the analysis and interpretation of any patch test data set. One such statistical phenomenon that

  18. Functions for patch test in finite element analysis of the Mindlin plate and the thin cylindrical shell

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Current patch test for Mindlin plate element only satisfies the zero shear deformation condition.The patch test of non-zero constant shear for Mindlin plate problem cannot be performed.For shell element, the patch test does not even exist.Based on the theory of enhanced patch test proposed by Chen W J (2006),the authors proposed the enhanced patch test function for Mindlin plate and thin cylindrical shell elements.This enhanced patch test function can be used to assess the convergence of the Mindlin plate and cylindrical thin shell elements.

  19. Test fields cannot destroy extremal black holes

    Science.gov (United States)

    Natário, José; Queimada, Leonel; Vicente, Rodrigo

    2016-09-01

    We prove that (possibly charged) test fields satisfying the null energy condition at the event horizon cannot overspin/overcharge extremal Kerr-Newman or Kerr-Newman-anti de Sitter black holes, that is, the weak cosmic censorship conjecture cannot be violated in the test field approximation. The argument relies on black hole thermodynamics (without assuming cosmic censorship), and does not depend on the precise nature of the fields. We also discuss generalizations of this result to other extremal black holes.

  20. Usefulness of intradermal test and patch test in the diagnosis of nonimmediate reactions to metamizol.

    Science.gov (United States)

    Macías, E; Ruiz, A; Moreno, E; Laffond, E; Dávila, I; Lorente, F

    2007-12-01

    Metamizole is a pyrazolone derivative, and its most common reactions are IgE-mediated reaction and idiosyncratic reactions. Non-immediate reactions are poorly described and there are very few reports on non-immediate reactions to pyrazolones. We evaluated 12 patients (nine men) who consulted for a non-immediate reaction after metamizol administration. We performed cutaneous tests (skin prick tests and immediate and delayed intradermal tests) and epicutaneous tests, and, if necessary, an oral challenge test. All skin prick and intradermal tests, if necessary, were negative in immediate reading. Delayed intradermal tests were positive in six of 10 patients (60%) and epicutaneous tests were positive in four of 11 patients (36%). Three cases (25%), were diagnosed by a positive oral challenge test. Delayed-reading intradermal tests and patch tests are useful tools in the diagnosis of nonimmediate reactions to pyrazolones and should be considered the first step when evaluating these type of reactions. Intradermal test appears to be more sensitive than patch test. The positivity of skin tests suggests an immunological reaction, probably mediated by T lymphocytes, but further studies are required.

  1. Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG.

    Science.gov (United States)

    Gruvberger, B; Andersen, K E; Brandão, F M; Bruynzeel, D P; Bruze, M; Frosch, P J; Goossens, A; Lahti, A; Lindberg, M; Menné, T; Orton, D; Seidenari, S

    2005-01-01

    Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. As there has been no agreement on which MDBGN test preparation to use, a study was initiated to help determine the optimal patch test preparation for MDBGN. 2661 consecutively patch tested patients at 11 test clinics representing 9 European countries participated. Petrolatum preparations with MDBGN at 1.0%, 0.5%, 0.3% and 0.1% were inserted in the standard series. Contact allergy rates were noted in the range 4.4-1.1% following decreasing test concentrations. Reactions not fulfilling all criteria to be classified as allergic reactions could represent either weak allergic or irritant reactions, and such reactions were noted in the range 8.2-0.5% with decreasing concentrations. A significant number of these reactions represented weak allergic reactions, as allergic reactions were obtained to higher patch test concentrations in the same individual. Morphologically irritant reactions were noted only for the highest test concentrations. In summary, the contact allergy rates and frequencies of doubtful and irritant reactions vary with the patch test concentration. The final decision on patch test concentration for MDBGN should not only rely on these factors but also include information on patch test concentrations required to diagnose individual cases with allergic contact dermatitis from MDBGN as well as results of repeated open application tests.

  2. European Society of Contact Dermatitis guideline for diagnostic patch testing -- recommendations on best practice

    DEFF Research Database (Denmark)

    Johansen, Jeanne D; Aalto-Korte, Kristiina; Agner, Tove

    2015-01-01

    The present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions...... and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special...

  3. A Herald Patch Almost Encircling the Trunk-Extreme Pityriasis Rosea Gigantea in a Young Child.

    Science.gov (United States)

    Chuh, Antonio

    2016-09-01

    An 18-month-old girl presented with pityriasis rosea gigantea. The herald patch encircled almost the entire trunk. The distribution of lesions on the trunk and proximal aspects of the limbs, the collarette scaling, the orientation of some lesions along the skin crease lines, and biopsy findings substantiated the diagnosis. © 2016 Wiley Periodicals, Inc.

  4. Influence of detergent washing powders on minimal eliciting patch test concentrations of nickel and chromium.

    Science.gov (United States)

    Allenby, C F; Goodwin, B F

    1983-11-01

    Minimum eliciting levels of nickel have been estimated in 25 nickel-sensitive subjects, and of chromium in 14 chromium-sensitive subjects by patch tests with aqueous solutions of the respective metals. The minimum level of each metal required to provoke a patch test reaction was considerably greater than that found in fabric washing powder solutions and was in the majority of patients tested of the order of 112 ppm nickel (0.05% nickel sulphate) or 885 ppm hexavalent chromium (0.25% potassium dichromate). One nickel-sensitive subject and one chromium-sensitive subject reacted to 1 ppm of the respective metal. Fabric washing powder did not significantly alter the patch test reaction to nickel sulphate or provoke reactions in nickel- or chromium-sensitive subjects. EDTA significantly reduced the number and severity of patch test reactions to nickel sulphate but not those to potassium dichromate or trivalent chromium.

  5. EX1101: Ship Shakedown and Patch Tests on NOAA Ship Okeanos Explorer (EM302)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project will involve the shakedown of all Okeanos Explorer ship capabilities and a patch test of the Kongsberg EM302 multibeam system. Operations for this...

  6. Hypersensitivity reactions to metallic implants-diagnostic algorithm and suggested patch test series for clinical use

    DEFF Research Database (Denmark)

    Schalock, Peter C; Menné, Torkil; Johansen, Jeanne D

    2011-01-01

    algorithm to guide the selection of screening allergen series for patch testing is provided. At a minimum, an extended baseline screening series and metal screening is necessary. Static and dynamic orthopaedic implants, intravascular stent devices, implanted defibrillators and dental and gynaecological......Cutaneous and systemic hypersensitivity reactions to implanted metals are challenging to evaluate and treat. Although they are uncommon, they do exist, and require appropriate and complete evaluation. This review summarizes the evidence regarding evaluation tools, especially patch and lymphocyte...... transformation tests, for hypersensitivity reactions to implanted metal devices. Patch test evaluation is the gold standard for metal hypersensitivity, although the results may be subjective. Regarding pre-implant testing, those patients with a reported history of metal dermatitis should be evaluated by patch...

  7. Illustration of the Impedance Behaviour of Extremely Low-Profile Coupled Shorted-Patches Antennas for UHF RFID of People

    Directory of Open Access Journals (Sweden)

    Milan Svanda

    2014-01-01

    Full Text Available The recently introduced coupled shorted-patches technique for the design of extremely low-profile UHF RFID tag antennas is used to illustrate the flexibility of selected feeding methods for tuning the antenna input impedance for the complex values required for matching with typical RFID chips. We present parametric studies of the impedance behaviour of dipole-excited and directly excited antennas designed for radiofrequency identification of people in the European UHF frequency band. Our study can significantly facilitate the design of this class of on-body tag antennas.

  8. Assessment criteria for MEG/EEG cortical patch tests

    Energy Technology Data Exchange (ETDEWEB)

    Im, Chang-Hwan [ENG420-040, School of Electrical Engineering, Seoul National University, Shillim-dong, Kwanak-gu, Seoul 151-742 (Korea, Republic of); An, Kwang-Ok [ENG420-040, School of Electrical Engineering, Seoul National University, Shillim-dong, Kwanak-gu, Seoul 151-742 (Korea, Republic of); Jung, Hyun-Kyo [ENG420-040, School of Electrical Engineering, Seoul National University, Shillim-dong, Kwanak-gu, Seoul 151-742 (Korea, Republic of); Kwon, Hyukchan [Korea Research Institute of Standards and Science, PO Box 102, Yuseong, Daejeon 305-600 (Korea, Republic of); Lee, Yong-Ho [Korea Research Institute of Standards and Science, PO Box 102, Yuseong, Daejeon 305-600 (Korea, Republic of)

    2003-08-07

    To validate newly developed methods or implemented software for magnetoencephalography/electroencephalography (MEG/EEG) source localization problems, many researchers have used human skull phantom experiments or artificially constructed forward data sets. Between the two methods, the use of an artificial data set constructed with forward calculation attains superiority over the use of a human skull phantom in that it is simple to implement, adjust and control various conditions. Nowadays, for the forward calculation, especially for the cortically distributed source models, generating artificial activation patches on a brain cortical surface has been popularized instead of activating some point dipole sources. However, no well-established assessment criterion to validate the reconstructed results quantitatively has yet been introduced. In this paper, we suggest some assessment criteria to compare and validate the various MEG/EEG source localization techniques or implemented software applied to the cortically distributed source model. Four different criteria can be used to measure accuracy, degrees of focalization, noise-robustness, existence of spurious sources and so on. To verify the usefulness of the proposed criteria, four different results from two different noise conditions and two different reconstruction techniques were compared for several patches. The simulated results show that the new criteria can provide us with a reliable index to validate the MEG/EEG source localization techniques.

  9. CLINICAL PROFILE OF HAND ECZEMA AND ITS EVALUATION BY PATCH TESTING

    Directory of Open Access Journals (Sweden)

    Shreeya

    2016-05-01

    Full Text Available BACKGROUND Allergic contact dermatitis (ACD is the classical presentation of delayed type hypersensitivity response to exogenous agents. The disease can have a chronic and relapsing course if the causal allergen is not identified. The best solution for ACD is avoidance of further exposure to the allergen. OBJECTIVES To identify the various presentations of hand eczema and to correlate the patch test results with the clinically suspected antigen. An attempt to identify the most common population affected and the frequently encountered allergen was made. METHODS The study was conducted at MVJ Medical College and Research Hospital, Bangalore. Patch test was done with Indian Standard Series and indigenous antigens. The patches were removed after approximately 48 hours, and reading was taken after 30 minutes. The results were recorded, tabulated and analysed according to statistical proportion. RESULTS: A total of 100 patients of hand eczema were studied. The incidence was 69% in males and 31% females. The male to female ratio was 2.3:1. The commonest occupation among males was construction work (36%, and most of the females were housewives (27%. Patch testing was positive in 51%, of which potassium dichromate (28, parthenium (11, paraphenylenediamine (7 were the common sensitisers. CONCLUSION Patch testing is a very useful investigative procedure for hand eczema, but association between clinical patterns and the allergens cannot be predicted with patch test alone. The Indian Standard series is useful to a certain extent, but insufficient.

  10. Attitudes about Advances in Sweat Patch Testing in Drug Courts: Insights from a Case Study in Southern California

    Science.gov (United States)

    Polzer, Katherine

    2010-01-01

    Drug courts are reinventing the drug testing framework by experimenting with new methods, including use of the sweat patch. The sweat patch is a band-aid like strip used to monitor drug court participants. The validity and reliability of the sweat patch as an effective testing method was examined, as well as the effectiveness, meaning how likely…

  11. Testing for tail behavior using extreme spacings

    CERN Document Server

    Rojo, J

    2010-01-01

    Methodologies to test hypotheses about the tail-heaviness of an underlying distribution are introduced based on results of Rojo (1996) using the limiting behavior of the extreme spacings. The tests are consistent and have point-wise robust levels in the sense of Lehmann (2005) and Lehmann and Loh (1990). Simulation results based on these new methodologies indicate that the tests exhibit good control of the probability of Type I error and have good power properties for finite sample sizes. The tests are compared with a test proposed by Bryson (1974) and it is seen that, although Bryson's test is competitive with the tests proposed here, Bryson's test does not have point-wise robust levels. The operating characteristics of the tests are also explored when the data is blocked. It turns out that the power increases substantially by blocking. The methodology is illustrated by analyzing various data sets.

  12. Inferring local competition intensity from patch size distributions: a test using biological soil crusts

    Science.gov (United States)

    Bowker, Matthew A.; Maestre, Fernando T.

    2012-01-01

    Dryland vegetation is inherently patchy. This patchiness goes on to impact ecology, hydrology, and biogeochemistry. Recently, researchers have proposed that dryland vegetation patch sizes follow a power law which is due to local plant facilitation. It is unknown what patch size distribution prevails when competition predominates over facilitation, or if such a pattern could be used to detect competition. We investigated this question in an alternative vegetation type, mosses and lichens of biological soil crusts, which exhibit a smaller scale patch-interpatch configuration. This micro-vegetation is characterized by competition for space. We proposed that multiplicative effects of genetics, environment and competition should result in a log-normal patch size distribution. When testing the prevalence of log-normal versus power law patch size distributions, we found that the log-normal was the better distribution in 53% of cases and a reasonable fit in 83%. In contrast, the power law was better in 39% of cases, and in 8% of instances both distributions fit equally well. We further hypothesized that the log-normal distribution parameters would be predictably influenced by competition strength. There was qualitative agreement between one of the distribution's parameters (μ) and a novel intransitive (lacking a 'best' competitor) competition index, suggesting that as intransitivity increases, patch sizes decrease. The correlation of μ with other competition indicators based on spatial segregation of species (the C-score) depended on aridity. In less arid sites, μ was negatively correlated with the C-score (suggesting smaller patches under stronger competition), while positive correlations (suggesting larger patches under stronger competition) were observed at more arid sites. We propose that this is due to an increasing prevalence of competition transitivity as aridity increases. These findings broaden the emerging theory surrounding dryland patch size distributions

  13. Patch testing with hair cosmetic series in Europe: a critical review and recommendation.

    Science.gov (United States)

    Uter, Wolfgang; Bensefa-Colas, Lynda; Frosch, Peter; Giménez-Arnau, Ana; John, Swen M; Lepoittevin, Jean-Pierre; Lidén, Carola; White, Ian R; Duus Johansen, Jeanne

    2015-08-01

    Many key ingredients of hair cosmetics (in particular, dyes, bleaches, and hair-styling agents) are potent (strong to extreme) contact allergens. Some heterogeneity is apparent from published results concerning the range of allergens for which patch testing is important. The objective of the present review was to collect information on the current practice of using 'hair cosmetic series', and discuss this against the background of evidence concerning consumer/professional exposure and regulatory aspects to finally derive a recommendation for a 'European hair cosmetic series'. The methods involved (i) a survey targeting all members of the COST action 'StanDerm' (TD1206) consortium, (ii) analysis of data in the database of the European Surveillance System on Contact Allergies (ESSCA), and (iii) literature review. Information from 19 European countries was available, partly from national networks, and partly from one or several departments of dermatology or, occasionally, occupational medicine. Apart from some substances being tested only in single departments, a broad overlap regarding 'important' allergens was evident. Some of the substances are no longer permitted for use in cosmetics (Annex II of the Cosmetics Regulation). An up-to-date 'European hair cosmetics series', as recommended in the present article, should (i) include broadly used and/or potent contact allergens, (ii) eliminate substances of only historical concern, and (iii) be continually updated as new evidence emerges.

  14. Recommendation to include methyldibromo glutaronitrile in the European standard patch test series.

    Science.gov (United States)

    Bruze, Magnus; Goossens, An; Gruvberger, Birgitta

    2005-01-01

    The preservative methyldibromo glutaronitrilc (MDBGN) is used non-occupationally and occupationally. High contact allergy rates have been reported when tested in consecutive dermatitis patients as well as clinical cases with allergic contact dermatitis. Up till now there has been no agreement on which patch test preparation to use to trace contact allergy to MDBGN. From the year 2005 on, MDBGN at 0.5% w/w in petrolatum is recommended for the European standard patch test series. The choice of 0.5% is based on consideration of rates of contact allergy, doubtful and irritant reactions, as well as on information on clinical relevance represented by results of a repeated open application test, and patch test concentrations to diagnose allergic contact dermatitis from MDBGN in individual cases.

  15. Investigation of a CTS solar cell test patch under simulated geomagnetic substorm charging conditions

    Science.gov (United States)

    Bogus, K. P.

    1977-01-01

    The CTS solar array technology experiment which consists of a solar cell test patch on the Kapton-substrate solar array and the appertaining electronics unit has been operating in geostationary orbit for nearly 1 year without any malfunction although it is expected to be strongly influenced by charging effects on the array surface. The results of a post-launch test program show that the experiment would not survive a discharge due to electrostatic charging in the test patch area. In a simulated substorm, environment discharges were obtained only below a temperature threshold of about 30 C. With solar illumination, this threshold is reduced below 0 C.

  16. Skin biopsy and quantitative sensory testing do not predict response to lidocaine patch in painful neuropathies.

    Science.gov (United States)

    Herrmann, David N; Pannoni, Valerie; Barbano, Richard L; Pennella-Vaughan, Janet; Dworkin, Robert H

    2006-01-01

    Predictors of response to neuropathic pain treatment in patients with painful distal sensory neuropathies are lacking. The 5% lidocaine patch is believed to exert its effects on neuropathic pain via a local stabilizing effect on cutaneous sensory afferents. As such, it provides a model to assess whether the status of epidermal innervation as determined by skin biopsy or quantitative sensory testing (QST) of small- and large-diameter sensory afferents might serve as predictors of response to topical, locally active treatment. In this study we assessed associations between epidermal nerve fiber (ENF) densities, sensory nerve conduction studies (NCS), QST, and response to a 5% lidocaine patch in patients with painful distal sensory neuropathies. We observed no association between distal leg epidermal and subepidermal innervation and response to the lidocaine patch. Several patients with complete loss of distal leg ENF showed a response to the lidocaine patch. Similarly we observed no consistent association between treatment response and QST for vibration, cooling, warm, heat-pain, and cold-pain thresholds, or distal sensory NCS. Thus, distal-leg skin biopsy, QST, and sensory NCS cannot be used to identify patients with painful polyneuropathy likely to respond to a lidocaine patch in clinical practice. Further studies are required to clarify precisely the mechanism and site of action of the lidocaine patch in patients with peripheral neuropathic pain.

  17. Primin in the European standard patch test series for 20 years

    DEFF Research Database (Denmark)

    Zachariae, Claus; Engkilde, Kåre; Johansen, Jeanne Duus

    2007-01-01

    Primin was included in the European standard series (ESS) in 1984. In 2000, a primin-free variant of Primula obconica, the main source of contact allergy to primin, was introduced in the market. The aim of this study was to analyse the trends of primin allergy in 13 986 consecutively patch......-tested eczema patients over a 20-year period from 1985 to 2004. 151 patients gave a positive patch test to primin. The majority were women, in two-third of patients the patch test was relevant and most presented with hand eczema. Only few of the cases (4.7%) were occupational. A significant decline of contact...... allergy to primin was seen (P

  18. Clinical patch test data evaluated by multivariate analysis. Danish Contact Dermatitis Group

    DEFF Research Database (Denmark)

    Christophersen, J; Menné, T; Tanghøj, P;

    1989-01-01

    patch tested with the standard series of the International Contact Dermatitis Research Group (ICDRG) by members of the Danish Contact Dermatitis Group (DCDG) over a period of 6 months. For the 8 test allergens most often found positive (nickel, fragrance-mix, cobalt, chromate, balsam of Peru, carba...

  19. Study of contact dermatitis due to topical medicaments and cosmetics by patch testing

    Directory of Open Access Journals (Sweden)

    Vij Amit

    2007-01-01

    Full Text Available Background: Contact dermatitis is the most common immunological disorder encountered by the dermatologist and it arises when a person develops delayed type of hypersensitivity reaction to a substance coming in contact with his skin. The patch test is at present a helpful test for demonstrating contact type of allergy that identifies the cause of allergic contact dermatitis. Aim: To study the common topical medicaments and cosmetics capable of producing contact dermatitis and value of patch testing in these situations. Materials and Methods: One hundred patients suspected of having contact sensitivity to topical medicaments and common cosmetics were subjected to patch testing with the finished commercial product being used by the patient and the antigens of the Indian Standard Series and Cosmetic series kit. Results: Positivity with patch test of 96.65% was observed in patients with contact dermatitis to topical medicaments, whereas 85% of the patients with cosmetic dermatitis were tested positive. Among the cases with contact dermatitis to topical medicaments, Neomycin was tested positive in more number of patients and among the patients with cosmetic dermatitis; Kum-Kum powder and Fairness cream were tested positive in more number of patients. Conclusion: It is well known that topical medicaments are known to produce contact dermatitis; the cosmetics that are claimed to be very safe by their manufacturers do not stay much behind in doing so.

  20. Patch testing with methyldibromo glutaronitrile, a multicentre study within the EECDRG

    DEFF Research Database (Denmark)

    Gruvberger, B; Andersen, Klaus Ejner; Brandão, F M

    2005-01-01

    Contact allergy to and allergic contact dermatitis from methyldibromo glutaronitrile (MDBGN) have frequently been reported. As there has been no agreement on which MDBGN test preparation to use, a study was initiated to help determine the optimal patch test preparation for MDBGN. 2661 consecutive...

  1. An 8-year experience with routine SL mix patch testing supplemented with Compositae mix in Denmark

    DEFF Research Database (Denmark)

    Paulsen, E; Andersen, Klaus Ejner; Hausen, B M

    2001-01-01

    Routine patch testing with sesquiterpene lactone (SL) mix, supplemented with Compositae mix (CM) and other Compositae extracts and allergens where appropriate, was evaluated over an 8-year period. 190 of 4386 patients tested (4.3%) were Compositae-sensitive, 143 females (mean age 51.5 years) and ...

  2. Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches

    DEFF Research Database (Denmark)

    Agner, T; Andersen, Klaus Ejner; Björkner, B;

    2001-01-01

    The preservatives imidazolidinyl urea (IMID, Germall 115) and diazolidinyl urea (DU, Germall II) are commonly used in cosmetic products and are well-known sensitizers. The aim of the present study was to establish the optimal patch test concentration in hydrophilic dried-in vehicle (TRUE Test...

  3. Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches

    DEFF Research Database (Denmark)

    Agner, T; Andersen, Klaus Ejner; Björkner, B

    2001-01-01

    The preservatives imidazolidinyl urea (IMID, Germall 115) and diazolidinyl urea (DU, Germall II) are commonly used in cosmetic products and are well-known sensitizers. The aim of the present study was to establish the optimal patch test concentration in hydrophilic dried-in vehicle (TRUE Test...

  4. Oxidation of resin acids in colophony (rosin) and its implications for patch testing.

    Science.gov (United States)

    Sadhra, S; Foulds, I S; Gray, C N

    1998-08-01

    Commercial preparations of colophony (rosin) used for patch testing are made from unmodified rosin in pet. and may be stored for some considerable time before being used. This would be satisfactory if the composition and dermatological activity of the preparations were both reproducible and stable, but investigations by the authors have shown that the resin acids undergo progressive and substantial oxidation and that the dermatological activity of the preparations increases significantly with time. This may be a cause of inconsistent patch test results unless the composition can be stabilized. Gas liquid chromatography (GLC) analysis of a raw rosin sample and its commercial patch test preparation has shown that they both contained the same resin acids, but the concentration of the abietic type resin acids was found to be lower in the patch test preparations. The degradation of resin acids is due to their atmospheric oxidation, which may occur during the preparation and storage of the commercial rosin patch test preparation. The susceptibility of individual resin acids to atmospheric oxidation was demonstrated by analysing a sample of raw Portuguese gum rosin, which was then left exposed to air and light. Most of the resin acids were found to undergo oxidation at a rate which gradually diminished. More importantly, it is presumed that the concentration of oxidized resin acids increased correspondingly, and these have been shown to be more dermatologically active than the unoxidised resin acids. The rate of decrease of resin acid concentration was found to be in the following order: neoabietic>levopimaric and palustric>abietic>dehydroabetic acid. The pimaric type resin acids were found to be relatively inert to atmospheric oxidation when compared with the abietic type resin acids. Patch testing with the resulting partly oxidized Portuguese rosin produced positive reactions at a 35% higher frequency than the raw Portuguese rosin. The study demonstrates that the

  5. EAACI Position Paper for practical patch testing in Allergic Contact Dermatitis in children

    DEFF Research Database (Denmark)

    de Waard-van der Spek, Flora B; Darsow, Ulf; Mortz, Charlotte G

    2015-01-01

    Allergic Contact Dermatitis (ACD) in children appears to be on the increase, and contact sensitization may already begin in infancy. The diagnosis of contact dermatitis requires a careful evaluation of a patient's clinical history, physical examination and skin testing. Patch testing is the gold...... allergens to be tested in children with suspected ACD. Additional tests should be performed only on specific indications. This article is protected by copyright. All rights reserved....

  6. Ethosome formulation of contact allergens may enhance patch test reactions in patients.

    Science.gov (United States)

    Madsen, Jakob Torp; Vogel, Stefan; Karlberg, Ann-Therese; Simonsson, Carl; Johansen, Jeanne Duus; Andersen, Klaus E

    2010-10-01

    Ethosomes and liposomes are ultra-small vesicles capable of encapsulating drugs and cosmetic ingredients for topical use, thereby potentially increasing bioavailability and clinical efficacy. So far, few reports have suggested that formulation of cosmetic ingredients in vesicular carrier systems may increase the allergenicity potential. To investigate the effect of ethosome formulation of isoeugenol and methyldibromo glutaronitrile on the elicitation response under patch test conditions and by repeated open applications. A total of 27 volunteer patients with a previous positive patch test reaction to either isoeugenol or methyldibromo glutaronitrile were included in the study. In all patients, a serial dilution patch test was performed with the allergen in question formulated in ethosomes and in an ethanol/water solution. In addition, a repeated open application test (ROAT) was performed in a subset of 16 patients, and lag time until a positive response was recorded. Both contact allergens encapsulated in ethosomes showed significantly enhanced patch test reactions as compared with the allergen preparation in ethanol/water without ethosomes. No significant difference in the median lag time was recorded between preparations in the ROAT. Encapsulating potential contact allergens in ethosomes may increase the challenge response as compared with the same concentrations in an ethanol/water base without ethosomes. © 2010 John Wiley & Sons A/S.

  7. EX1201: Ship Shakedown and Patch Tests on NOAA Ship Okeanos Explorer between 20100214 and 20120223

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — EX1201 is the 2012 shakedown mission of NOAA ship Okeanos Explorer (EX) and will perform system patch tests of the vessel’s Kongsberg EM302 multibeam sonar....

  8. Allergic contact dermatitis in Danish children referred for patch testing - a nationwide multicentre study

    DEFF Research Database (Denmark)

    Simonsen, Anne Birgitte; Deleuran, Mette; Mortz, Charlotte Gotthard;

    2014-01-01

    BACKGROUND: Although contact allergy among children was previously considered to be rare, data from the past decade have shown that it is common among children and that the prevalence may be increasing. OBJECTIVES: To describe the demographics of all children referred for patch testing in Denmark...

  9. A patch test confirmed phenobarbital-induced fixed drug eruption in a child.

    Science.gov (United States)

    Chadly, Zohra; Aouam, Karim; Chaabane, Amel; Belhadjali, Hichem; Abderrazzak Boughattas, Naceur; Zili, Jamel Eddine

    2014-06-01

    A-10-year-old girl was referred to our department for multiple hyperpigmented plaques. One week previously, she had been given one suppository of acetylsalicylic acid - phenobarbital for fever. Twelve hours after the drug intake the child developed pruritic red plaques on the left thigh. Six weeks after resolution of the acute reaction, patch tests were performed separately, with phenobarbital and acetylsalicylic acid. On 48-hour reading, only the phenobarbital patch test on residual pigmented lesion was positive. Because of possible cross-reactions between aromatic anticonvulsants, subsequent patch tests using carbamazepine and phenytoin on residual pigmented lesions were performed. They were all negative at 48-hour reading. To our knowledge, only two isolated pediatric cases of Phenobarbital-induced FDE have been reported in the literature. In this case report, as it was difficult to determine whether phenobarbital or acetylsalicylic acid was responsible for this reaction, subsequent patch tests allowed the identification of the culprit component since it was positive to phenobarbital.

  10. The optimal patch test concentration for ascaridole as a sensitizing component of tea tree oil

    NARCIS (Netherlands)

    Christoffers, Wietske Andrea; Bloemeke, Brunhilde; Coenraads, Pieter-Jan; Schuttelaar, Marie-Louise Anna

    2014-01-01

    BACKGROUND: Tea tree oil is used as a natural remedy, but is also a popular ingredient in household and cosmetic products. Oxidation of tea tree oil results in degradation products, such as ascaridole, which may cause allergic contact dermatitis. OBJECTIVES: To identify the optimal patch test concen

  11. Frequency of positive patch test reactions to preservatives: The Australian experience.

    Science.gov (United States)

    Chow, Elizabeth T; Avolio, Andrea M; Lee, Adriene; Nixon, Rosemary

    2013-02-01

    Preservatives are important causes of allergic contact dermatitis. The frequency of allergy to preservatives in Australia has been unknown to date. Our objectives are to report the frequency of positive preservative patch test reactions in Australia, comparing them to the published international data, as well as exploring the current regulations in place for preservative use in Australia. This was the first retrospective study of patch testing results, aggregated from four patch test clinics in three centres in Melbourne and Sydney. In all, 6845 patients were patch-tested during 1993-2006 and in this period the five most frequent preservative allergens were formaldehyde (4.6%), Euxyl K400 (containing methyldibromo glutaronitrile and phenoxyethanol) (3.3%), quaternium-15 (2.9%), diazolidinyl urea (2.4%), and methylchloroisothiazolinone/methylisothiazolinone (2.3%). These were followed by dimethylol dimethyl DMDM hydantoin (2.1%), chloroacetamide (2.1%) and imidazolidinyl urea (1.9%). The least frequent sensitisers were parabens (1.1%), 2-bromo-2-nitropropane-1, 3-diol (0.9%) and benzyl alcohol (0.4%). Formaldehyde was the most prevalent preservative allergen. Chloroacetamide allergy was more commonly seen in Australia. Parabens, 2-bromo-2-nitropropane-1,3-diol and benzyl alcohol were the least frequent sensitisers. Household products in Australia are not required to list all ingredients preventing sensitised individuals from properly assessing their exposure. © 2012 The Authors Australasian Journal of Dermatology © 2012 The Australasian College of Dermatologists.

  12. Hydroxychloroquine-induced acute generalized exanthematous pustulosis with positive patch-testing

    Directory of Open Access Journals (Sweden)

    Ons Charfi

    2015-01-01

    Full Text Available Acute generalized exanthematous pustulosis (AGEP is a severe cutaneous adverse reaction, mostly induced by drugs. Hydroxychloroquine have been rarely reported in literature as a causative drug of this reaction. We report a case of AGEP induced by hydroxychloroquine with systemic involvement and confirmed by positive patch testing.

  13. Hypersensitivity reactions to metallic implants-diagnostic algorithm and suggested patch test series for clinical use

    DEFF Research Database (Denmark)

    Schalock, Peter C; Menné, Torkil; Johansen, Jeanne D

    2011-01-01

    algorithm to guide the selection of screening allergen series for patch testing is provided. At a minimum, an extended baseline screening series and metal screening is necessary. Static and dynamic orthopaedic implants, intravascular stent devices, implanted defibrillators and dental and gynaecological...

  14. The dose-response relationship between the patch test and ROAT and the potential use for regulatory purposes

    DEFF Research Database (Denmark)

    Fischer, Louise Arup; Voelund, Aage; Andersen, Klaus Ejner

    2009-01-01

    BACKGROUND: Allergic contact dermatitis is common and can be prevented. The relationship between thresholds for patch tests and the repeated open application test (ROAT) is unclear. It would be desirable if patch test and ROAT data from already sensitized individuals could be used in prevention. ...

  15. Patch test results in patients with allergic contact dermatitis in Yozgat

    Directory of Open Access Journals (Sweden)

    Emine Çölgeçen Özel

    2013-09-01

    Full Text Available Background and Design: Patch testing is valuable in the diagnosis of allergic contact dermatitis (ACD as well as in determining the causative agent and thus is helpful in prevention of the disease and also provides information for the patient Material and Method: Hundred and sixty-eight patients (94 female and 74 male with ACD were patch tested with European standard series. Patch test result were assessed according to suggestion of International Contact Dermatitis Research Group at 48 and 72 hours after initial application. Results: Of the patients, 64.3% were between 16-45 years of age and majority of the lesions (57.1% were localized on the hands. A total of 86 (51.1% patients had one or more positive patch test reactions. The most common allergens were nickel sulfate (20.2% followed by potassium dichromate (8.3%, cobalt chloride (7.1%, fragrance mix (7.1%, paraphenylendiamine base (6%, paraben mix 3.6%, N-isopropyl-N-phenyl-p-phenylenediamine (3.6%, wool alcohols (3.6%, formaldehyde (3.6%, quaternium-15 (3.6%. Positive reactions to nickel sulfate were more common among women, especially those in younger group. Frequency of contact allergy to neomycin sulfate, epoxy resin, 4-tert-butylphenolformaldehyde resin, sesquiterpenelactone mix, primin, 5-chloro-2-methyl-4-isothiazolin-3-1, budesonide, lyral were relatively low (1.2%, while no positive reaction was obtained to clioquinol and methyldibromoglutaronitrile in any case. Conclusion: Since no similar study has been previously performed in our area, this study provides information about contact allergen profile in patients underwent skin patch test with a diagnosis of AKD at Yozgat. The most frequent allergens detected with ASS and frequency rates may vary among different facilities at various cities of Turkey. A standard series for our country may be created after assessment of regional variability by new studies conducted in same time zone.

  16. Is Patch Testing with Food Additives Useful in Children with Atopic Eczema?

    Science.gov (United States)

    Catli, Gonul; Bostanci, Ilknur; Ozmen, Serap; Dibek Misirlioglu, Emine; Duman, Handan; Ertan, Ulker

    2015-01-01

    Atopy patch testing is a useful way to determine delayed-type hypersensitivity reactions to foods and aeroallergens. Although food additives have been accused of worsening atopic eczema symptoms, according to recent studies the role of food additives in atopic eczema remains unclear. The purpose of our study was to investigate food additive hypersensitivity in a group of children with atopic eczema by using standardized atopy patch testing and to determine the role of food additive hypersensitivity in atopic eczema. Thirty-four children with atopic eczema and 33 healthy children were enrolled in the study. Children who consumed foods containing additives and did not use either antihistamines or local or systemic corticosteroids for at least 7 days prior to admission were enrolled in the study. All children were subjected to atopy patch testing and after 48 and 72 hours their skin reactions were evaluated by using the guidelines. Positive atopy patch test results were significantly higher in the atopic eczema group. Forty-one percent of the atopic eczema group (n = 14) and 15.2% (n = 5) of the control group had positive atopy patch test results with food additives (p = 0.036) (estimated relative risk 1.68, case odds 0.7, control odds 0.17). Carmine hypersensitivity and the consumption of foods containing carmine, such as gumdrops, salami, and sausage, were significantly higher in the children with atopic eczema. This is the first study investigating hypersensitivity to food additives in children with atopic eczema. Our results indicate that carmine may play a role in atopic eczema. © 2015 Wiley Periodicals, Inc.

  17. [Contact allergy to gold and its alloys. Pertinence of gold salt patch tests].

    Science.gov (United States)

    Collet, E; Lacroix, M; Dalac, S; Ponnelle, C; Lambert, D

    1994-01-01

    Allergic contact dermatitis to gold and its alloys is a rare affection and it is difficult to interpret gold salts patch tests. We report two cases of patients with positive patch tests to 0.5% sodium aurothiosulfate discovered during a dermatology exploration of an occupational contact eczema (for the first patient) and an intolerance to gold jewelry (for the second). There is much confusion in the literature concerning the allergologic exploration of contact dermatitis to gold: no standardized test, possible cross reactions between different gold salts, the tests often irritate. The mechanism of sensitization to gold salts is unknown since pure gold is inalterable and does not contain any salts. The pertinence of a positive test to one or more gold salts must therefore be examined carefully and the diagnosis of gold allergy must not be made without sufficient evidence.

  18. The dose-response relationship between the patch test and ROAT and the potential use for regulatory purposes.

    Science.gov (United States)

    Fischer, Louise Arup; Voelund, Aage; Andersen, Klaus Ejner; Menné, Torkil; Johansen, Jeanne Duus

    2009-10-01

    Allergic contact dermatitis is common and can be prevented. The relationship between thresholds for patch tests and the repeated open application test (ROAT) is unclear. It would be desirable if patch test and ROAT data from already sensitized individuals could be used in prevention. The aim was to develop an equation that could predict the response to an allergen in a ROAT based on the dose-response curve derived by patch testing. Results from two human experimental elicitation studies with non-volatile allergens, nickel and the preservative methyldibromo glutaronitrile (MDBGN), were analysed by logistic dose-response statistics. The relation for volatile compounds was investigated using the results from experiments with the fragrance chemicals hydroxyisohexyl 3-cyclohexene carboxaldehyde and isoeugenol. For non-volatile compounds, the outcome of a ROAT can be estimated from the patch test by: ED(xx)(ROAT) = 0.0296 ED(xx)(patch test). For volatile compounds, the equation predicts that the response in the ROAT is more severe than the patch test response, but it overestimates the response. This equation may be used for non-volatile compounds other than nickel and MDBGN, after further validation. The relationship between the patch test and the ROAT can be used for prevention, to set safe levels of allergen exposure based on patch test data.

  19. Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients

    DEFF Research Database (Denmark)

    Bennike, Niels Højsager; Johansen, Jeanne Duus

    2016-01-01

    BACKGROUND: Sorbitan sesquioleate (SSO) has been added to fragrance mix I (FM I) as an emulsifier since the 1990s. Being a contact allergen itself, SSO has the potential to cause false-positive reactions to FM I. Recent results obtained with selected FM I-positive patients have shown that 5% have...... concomitant positive reactions to SSO. OBJECTIVES: To investigate the 5-year prevalence of contact allergy to SSO and evaluate the importance of SSO allergy when patch test results for FM I are interpreted. METHODS: This was a retrospective database study of consecutively patch tested eczema patients (n = 4 6...... 3 7) from 2010 to 2014. All patients were tested with our baseline series including FM I and SSO 20% in pet. RESULTS: Sensitization to SSO was identified in 9 (0.2%) patients. The proportion of FM I-positive patients with concomitant positive reactions to SSO was 1.4%. CONCLUSIONS: SSO is a rare...

  20. Increase in contact allergy to fragrances: patch-test results 1989-1998.

    Science.gov (United States)

    Lunder, T; Kansky, A

    2000-08-01

    We report the results of patch tests with fragrance-mix as a part of the standard series carried out over the last 10 years (1989-1998) during routine testing of 6129 patients in our department. 5.9% of the total number of patients who were patch tested were positive to fragrance mix. The sex ratio was 2.3:1 with a female predominance. In 1989-1993, the frequency of contact sensitivity to fragrance mix was 3.9% (4.9% for females and 2.1% for males). This rate rose both in female and male patients during the observed period of time and attained 8.9% (females) and 4.1% (males) in 1994-1998; the overall frequency in 1994-98 was 7.5%. This rising trend, which was statistically significant, might be the consequence of an increased use of cosmetics and toiletries containing fragrances in our population.

  1. Patch test reactivity to feverfew-containing creams in feverfew-allergic patients

    DEFF Research Database (Denmark)

    Paulsen, Evy; Christensen, Lars P; Fretté, Xavier

    2010-01-01

    Background: The Compositae plant feverfew (Tanacetum parthenium) has long been recognized as an important sensitizer in European Compositae-allergic patients, mainly because of its content of the sesquiterpene lactone parthenolide. Recently, a parthenolide-depleted feverfew extract with claimed...... with feverfew contact allergy were patch tested with two creams containing the feverfew extract. Subsequently, the creams were analysed by liquid chromatography with tandem mass spectrometry to detect parthenolide. Results: Four of the patients tested positive to one of the creams; reactivity was associated...... with simultaneous positive reactions to parthenolide. This cream was analysed about 2 years later, and no parthenolide was detected, probably because of degradation of the compound. Conclusions: Topical products containing parthenolide-depleted feverfew extracts may elicit positive patch test reactions in feverfew...

  2. Quantitative patch and repeated open application testing in methyldibromo glutaronitrile-sensitive patients.

    Science.gov (United States)

    Schnuch, A; Kelterer, D; Bauer, A; Schuster, Ch; Aberer, W; Mahler, V; Katzer, K; Rakoski, J; Jappe, U; Krautheim, A; Bircher, A; Koch, P; Worm, M; Löffler, H; Hillen, U; Frosch, P J; Uter, W

    2005-04-01

    Contact allergy to methyldibromo glutaronitrile (MDBGN), often combined with phenoxyethanol (PE) (e.g., Euxyl K 400), increased throughout the 1990s in Europe. Consequently, in 2003, the European Commission banned its use in leave-on products, where its use concentration was considered too high and the non-sensitizing use concentration as yet unknown. The 2 objectives of the study are (a) to find a maximum non-eliciting concentration in a leave-on product in MDBGN/PE-sensitized patients, which could possibly also be considered safe regarding induction and (b) to find the best patch test concentration for MDBGN. We, therefore, performed a use-related test (ROAT) in patients sensitized to MDBGN/PE (n = 39) with 3 concentrations of MDBGN/PE (50, 100 and 250 p.p.m. MDBGN, respectively). A subset of these patients (n = 24) was later patch-tested with various concentrations (0.1, 0.2, 0.3 and 0.5% MDBGN, respectively). 15 patients (38%, 95% confidence interval (CI) = 23-55%) had a negative and 24 (62%; 95% CI = 45-77%) a positive overall repeated open application test (ROAT) result. 13 reacted to the lowest (50 p.p.m.), 8 to the middle (100 p.p.m.) and 3 to the highest concentration (250 p.p.m.) only. In those 13 reacting to the lowest ROAT concentration, dermatitis developed within a few days (1-7). The strength of the initial and the confirmatory patch test result, respectively, and the outcome of the ROAT were positively associated. Of the 24 patients with a use and confirmatory patch test, 15 reacted to 0.1% MDBGN, 16 to 0.2%, 17 to 0.3% and 22 to 0.5%. With the patch test concentration of 0.5%, the number of ROAT-negative patients but patch-test-positive patients increases considerably, particularly due to + reactions. A maximum sensitivity of 94% (95% CI = 70-100%) is reached with a patch test concentration of 0.2%, and is not further improved by increasing the concentration. However, the specificity decreases dramatically from 88 (95% CI = 47-100%) with 0.2% to a

  3. Patch testing with markers of fragrance contact allergy. Do clinical tests correspond to patients' self-reported problems?

    DEFF Research Database (Denmark)

    Johansen, J D; Andersen, T F; Veien, N

    1997-01-01

    The aim of the present study was to investigate the relationship between patients' own recognition of skin problems using consumer products and the results of patch testing with markers of fragrance sensitization. Eight hundred and eighty-four consecutive eczema patients, 18-69 years of age, fill...

  4. Comparison of European Standard Patch Test Results of 330 Patients from an Occupational Diseases Hospital

    Directory of Open Access Journals (Sweden)

    Özge Gündüz

    2016-01-01

    Full Text Available Background and Aim. Contact dermatitis (CD is the most prevalent occupational skin disease with a significant impact on quality of life. Patch testing is used for the identification of responsible allergens which may improve protective and preventive measures in the workplace. Herein, we aim to identify the demographic characteristics and occupation of patients with early diagnosis of occupational CD and compare patch test results. Materials and Methods. The study included 330 patients referred to our clinic between April 2009 and April 2011 and who were patch-tested with 28-allergen European Standard Test. Results. 126 (38% patients were female and 204 (62% were male with a mean age of 36.12 (±13.13 years. Positive allergic reactions were observed in 182 (55% patients. Nickel sulphate (41/126 and potassium dichromate (39/204 were significantly the most common allergens in women and men, respectively (P<0.005. Additionally, the most common occupation in women was household activities (83/126 and in men was manufacturing (80/204. Conclusion. The allergens to which people become sensitized differ according to their working environment and occupation. Classification of occupations is important for identification of sensitization risks and monitoring of changes in allergen distribution of different occupations.

  5. Etoricoxib-induced fixed drug eruption with positive lesional patch tests.

    Science.gov (United States)

    Calistru, Ana Maria; Cunha, Ana Paula; Nogueira, Ana; Azevedo, Filomena

    2011-06-01

    Fixed drug eruption (FDE) is most commonly associated with antibiotics, anticonvulsants, and nonnarcotic analgens, including nonsteroidal anti-inflammatory drugs (NSAIDs). However, the newer cyclooxygenase 2 (COX-2) inhibitors have been rarely reported to cause FDE. We report the case of a 52-year-old Caucasian woman with erythematous pruritic plaques on the neck, left forearm, and second finger of the right hand, healing with hyperpigmentation and recurring in the same locations. The patient was sporadically taking oral etoricoxib 90 mg for her back pain and noticed the relation between administration of the drug and skin lesions, the time interval decreasing progressively from 1 week to 30 minutes. No other signs, symptoms, or drug intake was mentioned. The patch tests with etoricoxib 1% and 5% in petrolatum were positive at the location of the lesions and negative on the back (nonlesional skin). Standard European and NSAID series were negative. Patch tests of 10 healthy controls with etoricoxib 1% and 5% in petrolatum were negative. After the avoidance of the drug, no relapse was mentioned. The patch test was reliable for the diagnosis of FDE, avoiding the need for subsequent oral provocation testing and therefore preventing the possible adverse effects. Despite being regarded as a safe drug, the occurrence of cutaneous adverse reactions to etoricoxib should be considered, especially in the setting of its increasing use in pain control.

  6. Patch Testing With Shoe Series In Suspected Cases Of Footwear Dermatitis

    Directory of Open Access Journals (Sweden)

    Eapen Bell Raj

    2001-01-01

    Full Text Available One hundred fifty nine patients with clinically suspected footwear dermatitis were patch tested to determine the frequency of positivity of common footwear antigens. Patch testing was done with 22 allergens of Shoe series (Chemotechnique Diagnostics AB Sweden extended with neomycin, gentamycin, soframycin, paraben, cresol and lanolin. Forty- two percent of patients was sensitive to footwear allergen(s whereas the overall positivity was 62%. Potassium dichromate. 2 mercapto- benzothiazole (MBT and nickel sulphate were the frequent sensitizers followed by gentamycin, neomycin, gluteraldehyde, formaldehyde, diphenyl guanidine, diphenyl thiourea, dibutyl thiourea, para-tertiary butyl phenol and 4 aminoazobenzene. Dorsa of feet was the commonest site. potassium dichromate sensitivity was higher in males and the history was not always helpful in incriminating the antigen.

  7. Allergic contact dermatitis from exotic woods: importance of patch-testing with patient-provided samples.

    Science.gov (United States)

    Podjasek, Joshua O; Cook-Norris, Robert H; Richardson, Donna M; Drage, Lisa A; Davis, Mark D P

    2011-01-01

    Exotic woods from tropical and subtropical regions (eg, from South America, south Asia, and Africa) frequently are used occupationally and recreationally by woodworkers and hobbyists. These exotic woods more commonly provoke irritant contact dermatitis reactions, but they also can provoke allergic contact dermatitis reactions. We report three patients seen at Mayo Clinic (Rochester, MN) with allergic contact dermatitis reactions to exotic woods. Patch testing was performed and included patient-provided wood samples. Avoidance of identified allergens was recommended. For all patients, the dermatitis cleared or improved after avoidance of the identified allergens. Clinicians must be aware of the potential for allergic contact dermatitis reactions to compounds in exotic woods. Patch testing should be performed with suspected woods for diagnostic confirmation and allowance of subsequent avoidance of the allergens.

  8. Patch testing with dermatophagoides and its correlation with chronic eczema and atopic dermatitis

    Directory of Open Access Journals (Sweden)

    Kapur Chetna

    2009-01-01

    Full Text Available Background: Chronic eczema is commonly encountered in the Indian set up. So also is atopic dermatitis. House dust mites (Dermatophagoides are implicated in various diseases like atopic dermatitis, asthma, and perennial rhinitis. It has also been proven that patch testing with Dermatophagoides pteronyssinus (DP is important for detection of contact sensitization in chronic dermatitis. Aims: To study clinical characteristics of DP mix positive patients with regards to chronic dermatitis and atopic dermatitis. Methods: Dermatology outpatients presenting to the department of Skin and STD of Kasturba Medical College (KMC, with clinically diagnosed atopic dermatitis and chronic eczema were chosen for the study. Inclusion and exclusion criteria were well demarked. Eighty six randomly selected patients of dermatitis were subjected to patch testing with standard series and DP mix. Results: Of the 86, 50 (58% showed positive reaction to DP mix. Among these positive patients, chronic dermatitis was seen in 42 (84% with involvement of exposed parts in 37 (74%. Atopic dermatitis was seen in 19 patients (38% from DP positive group whereas it was observed in 4 patients (17% from the other group. Conclusion: Dermatophagoides mix positivity was statistically significant in chronic eczema as well as atopic dermatitis. Patch testing is an important tool to detect delayed type allergy to house dust mite.

  9. Application of patch test in meshless analysis of continuously non-homogeneous piezoelectric circular plate

    Directory of Open Access Journals (Sweden)

    Staňák P.

    2013-06-01

    Full Text Available Proposed paper presents application of the patch test for meshless analysis of piezoelectric circular plate with functionally graded material properties. Functionally graded materials (FGM are the special class of composite materials with continuous variation of volume fraction of constituents in predominant direction. Patch test analysis is an important tool in numerical methods for addressing the convergence. Meshless local Petrov-Galerkin (MLPG method together with moving least-squares (MLS approximation scheme is applied in the analysis. No finite elements are required for approximation or integration of unknown quantities. Circular plate is considered as a 3-D axisymmetric piezoelectric solid. Considering the axial symmetry, the problem is reduced to a 2-dimensinal one. Displacement and electric potential fields are prescribed on the outer boundaries in order to reach the state of constant stress field inside the considered plate as required by the patch test and the governing equations. Values of prescribed mechanical and electrical fields must be determined in order to comply with applied FGM gradation rule. Convergence study is performed to assess the considered meshless approach and several conclusions are finally presented.

  10. The European baseline series in Lithuania: results of patch testing in consecutive adult patients.

    Science.gov (United States)

    Beliauskiene, A; Valiukeviciene, S; Uter, W; Schnuch, A

    2011-01-01

    In Lithuania, data on patch testing are lacking and the applicability of the European baseline series needs to be evaluated. The aim of the study was to examine the prevalence of contact allergy to the European baseline series in the population of patients with suspected allergic contact dermatitis in Lithuania. Between April 2006 and October 2008, 816 consecutive adult patients referred to the Department of Skin and Venereal Diseases, Kaunas University of Medicine, with suspected allergic contact dermatitis were patch tested with the European baseline series. Demographic data were collected in accordance with the European Surveillance System on Contact Allergies 'minimal data set'. The positive patch test was observed in 384 (47.4%) patients. The most prevalent contact allergens were nickel sulphate (17.1%), Myroxylon pereirae resin (8.0%), p-phenylenediamine (6.0%), methyldibromo glutaronitrile (5.5%) and colophonium (5.0%). The sex and age factors strongly influenced the prevalence of nickel sensitization. The lowest sensitization prevalences were found to N-isopropyl-N'-phenyl-p-phenylene diamine (0.1%) and 2-mercaptobenzothiazole (0.1%). Differences in the sensitization prevalences to some allergens of the European baseline series compared with other European countries were recognized. The current European baseline series is a suitable diagnostic tool for contact allergy in Lithuania. © 2010 The Authors. Journal of the European Academy of Dermatology and Venereology © 2010 European Academy of Dermatology and Venereology.

  11. Patch testing with patients' own cosmetics and toiletries--results of the IVDK*, 1998-2002.

    Science.gov (United States)

    Uter, Wolfgang; Balzer, Christina; Geier, Johannes; Frosch, Peter J; Schnuch, Axel

    2005-10-01

    Patch test results with products brought in by the patients collected by the members of the Information Network of Departments of Dermatology (IVDK) between 1998 and 2002 were analysed. 5911 patients were patch tested with their own cosmetics and toiletries during this period. The 34 082 single test preparations applied to these 5911 patients were manually assigned to 1 of 26 categories, based on the EU Classification Annex I to 76/768/EEC, which had been further refined. The leave-on product category most commonly tested was 'creams, emulsions, lotions, gels and oils for the skin' (n = 3621 tested, n = 312 positive). The rinse-off product type most commonly tested was 'bath and shower preparations' (n = 1333 tested, n = 71 positive). In one-third of patients tested positive to these products, no other positive test result was observed. In the remainder, positive reactions to the fragrance mix, Myroxylon pereirae resin, methyldibromo glutaronitrile, (chloro-)methylisothiazolinone, 2-bromo-2-nitropropane-1,3-diole and further ingredients of cosmetics and toiletries were more common than in product-negative patients. However, in view of the potential for false-positive reactions mainly to rinse-off products, the results must be interpreted with caution. In conclusion, testing of patients' own products can be regarded as efficient and safe, if in accordance with current recommendations.

  12. Routine patch testing with the sesquiterpene lactone mix in Europe: a 2-year experience

    DEFF Research Database (Denmark)

    Paulsen, E; Andersen, Klaus Ejner; Brandão, F M

    1999-01-01

    To test the screening value of the sesquiterpene lactone (SL) mix in Europe today and describe epidemiological and clinical features of Compositae-sensitive patients, the SL mix 0.1% pet. was included in the standard patch test series in 11 European clinics. 10,695 patients were tested, and 106 (1...... proportion of the patients. More than 1/3 were positive to perfume and/or colophony, possibly reflecting cross-reactivity. With only 1 case of active sensitization and no irritant reactions, the SL mix is a safe allergen and the overall prevalence of positive reactions supports its continued use...

  13. Patch testing with own cosmetics-- prospective study of testing and reporting of adverse effects to the Swedish Medical Products Agency.

    Science.gov (United States)

    Tammela, Monica; Lindberg, Magnus; Isaksson, Marléne; Inerot, Annica; Rudel, Jana; Berne, Berit

    2012-07-01

    The Swedish Medical Products Agency (MPA) provides a voluntary reporting system for adverse reactions to cosmetics. However, the reporting is sparse, and the products involved are sometimes difficult to identify. To investigate how often patients referred for patch testing were tested with the cosmetic products that they had been using themselves, and to improve the reporting to the MPA by the use of photographic documentation of product labels. Consecutive patients at five dermatology departments who were patch tested with their own cosmetics were included. Reports including protocols of positive patch test results for the patients' own cosmetics and photographs/photocopies of product labels were sent to the MPA. Three hundred and sixteen of 948 patients (33%) were tested with their own cosmetics, and 15% of these tested positive with one or more products. The number of reports was more than three times higher than in corresponding periods in earlier years. For 79% of the products, photographs/photocopies of the containers were submitted, and for 30%, batch numbers were submitted. For a substantial number of patients, their own cosmetics were suspected of causing adverse reactions and were therefore tested. During the study, the number of reports to the MPA tripled, and the relevant products were easier to identify. © 2012 John Wiley & Sons A/S.

  14. [Contact allergens in the standard patch test series from 1980-2004 at the University Clinic Aachen].

    Science.gov (United States)

    Hoeller Obrigkeit, D; Vens, N; Merk, H F; Schroeder, C M

    2005-12-01

    Allergic contact dermatitis is a common disease whose specific therapy is avoidance of allergens. It is critical to identify frequency of occurrence of allergic reactions to initiate preventive measures (e.g. elimination of substances with an especially high allergic potential). This study analyzes results of patch testing performed between 1980 and 1993 at the University Clinic of the RWTH Aachen. Additionally, age and sex-related distribution was evaluated. The data is compared to published patch test results covering the years 1995-2001 and patch test results from 2004 in the University Clinic Aachen.

  15. Evaluation of patients with oral lichenoid lesions by dental patch testing and results of removal of the dental restoration material

    Directory of Open Access Journals (Sweden)

    Emine Buket Şahin

    2016-12-01

    Full Text Available Background and Design: Oral lichenoid lesions (OLL are contact stomatitis characterized by white reticular or erosive patches, plaque-like lesions that are clinically and histopathologically indistinguishable from oral lichen planus (OLP. Amalgam dental fillings and dental restoration materials are among the etiologic agents. In the present study, it was aimed to evaluate the standard and dental series patch tests in patients with OLL in comparison to a control group and evaluate our results. Materials and Methods: Thirty-three patients with OLL or OLP and 30 healthy control subjects, who had at least one dental restoration material and/or dental filling, were included in the study. Both groups received standard series and dental patch test and the results were evaluated simultaneously. Results: The most frequent allergens in the dental series patch test in the patient group were palladium chloride (n=4; 12.12% and benzoyl peroxide (n=2, 6.06%. Of the 33 patients with OLL; 8 had positive reaction to allergents in the standard patch test series and 8 had positive reaction in the dental patch test series. There was no significant difference in the rate of patch test reaction to the dental and standard series between the groups. Ten patients were advised to have the dental restoration material removed according to the results of the patch tests. The lesions improved in three patients [removal of all amalgam dental fillings (n=1, replacement of all amalgam dental fillings with an alternative filling material (n=1 and replacement of the dental prosthesis (n=1] following the removal or replacement of the dental restoration material. Conclusion: Dental patch test should be performed in patients with OLL and dental restoration material. Dental filling and/or prosthesis should be removed/replaced if there is a reaction against a dental restoration material-related allergen.

  16. Patch Testing To a Textile Dye Mix by the International Contact Dermatitis Research Group

    DEFF Research Database (Denmark)

    Isaksson, Marléne; Ale, Iris; Andersen, Klaus E;

    2015-01-01

    BACKGROUND: Disperse dyes are well-known contact sensitizers not included in the majority of commercially available baseline series. OBJECTIVE: To investigate the outcome of patch testing to a textile dye mix (TDM) consisting of 8 disperse dyes. METHODS: Two thousand four hundred ninety.......2%. The most frequent dye allergen in the TDM-positive patients was D Orange 3. CONCLUSIONS: Over 30% of the TDM allergic patients had been missed if only the international baseline series was tested. Contact allergy to TDM could explain or contribute to dermatitis in over 20% of the patients. Textile dye mix...

  17. Stability of selected volatile contact allergens in different patch test chambers under different storage conditions

    DEFF Research Database (Denmark)

    Mose, Kristian Fredløv; Andersen, Klaus Ejner; Christensen, Lars Porskjaer

    2012-01-01

    storage conditions. Methods. Petrolatum samples of methyl methacrylate (MMA), 2-hydroxyethyl methacrylate (2-HEMA), 2-hydroxypropyl acrylate (2-HPA), cinnamal and eugenol in patch test concentrations were stored in three different test chambers (IQ chamber™, IQ Ultimate™, and Van der Bend® transport...... during storage in the refrigerator. For these two chamber systems, the contact allergen concentration dropped below the stability limit in the following order: MMA, cinnamal, 2-HPA, eugenol, and 2-HEMA. In the Van der Bend® transport container, the contact allergens exhibited acceptable stability under...

  18. Histological distinction between early allergic and irritant patch test reactions: follicular spongiosis may be characteristic of early allergic contact dermatitis

    DEFF Research Database (Denmark)

    Vestergaard, L; Clemmensen, Ole; Sørensen, Flemming Brandt;

    1999-01-01

    differentiate between early allergic and irritant patch test reactions. 8 patients with known contact allergy to either colophony or quarternium-15 participated in the study. In each patient, allergic and irritant patch tests reactions were elicited, and 4-mm punch biopsies were taken after 6 8 h from......Comparative light microscopic studies have revealed subtle differences between allergic and irritant reactions in the skin. In the search for specific differences, we focussed on the early inflammatory response. This pilot study was conducted to test the hypothesis that follicular spongiosis can...... clinically equipotent reactions. Paired sets of slides were assessed blindly by 2 pathologists. 1 patient showing a pityrosporum folliculitis was excluded from the study. All biopsies from allergic patch tests were characterized by follicular spongiosis, while biopsies from irritant patch tests showed...

  19. Patch test concentrations (doses in mg/cm(2) ) for the 12 non-mix fragrance substances regulated by European legislation

    DEFF Research Database (Denmark)

    Bruze, Magnus; Svedman, Cecilia; Andersen, Klaus Ejner;

    2012-01-01

    Background. According to EU legislation, 26 fragrance substance allergens must be labelled on cosmetic products. For 12 of them, the optimal patch test concentration/dose has not been evaluated. Objectives. To establish the optimal patch test doses in mg/cm(2) for the 12 fragrance substances......, it is recommended that half of the maximum patch test dose (mg/cm(2) ) be used for aimed and screening patch testing....

  20. Patch testing for allergic contact dermatitis: Three years retrospective results in Tekirdağ

    Directory of Open Access Journals (Sweden)

    Gamze Erfan

    2015-06-01

    Full Text Available Background and Design: Allergic contact dermatitis is a delayed type hypersensitivity reaction to allergens in individuals who were sensitized with same allergens before. The causative allergens may change in time as well as vary among geographical and population based differences. Materials and Methods: The characteristics of 169 patients-107 (63.3% male, 62 (36.7% female, who patch tested between 2011- 2014 with allergic contact dermatitis diagnosis and test results were retrospectively analysed. Results: The mean age of all patients who had the most frequent occupation as service sector/house wife (26.6% were 41.06 years and the mean disease duration of all patients was 19.5 months. The most frequent localization of disease was hands (n: 105,%73 and %50.3 of patients had positivity with at least one allergen. The most frequent seven allergens with positivity were nickel sulfate (n: 50, %29.6, cobalt chloride (n: 23, %13.6, potassium dichromate (n: 22, %13, sesquiterpene lactone mix (n: 18, %10.7, thiuram (n: 10, %5.9, clioquinol mix (n: 10, %5.9 and 4-tert-butilfenol formaldehyde resin (n: 10, %5.9, respectively. On the other hand in all patients there were no positivity with N-Isopropyl-N-phenyl-4-phenylenediamine, epoxy resin, balsam of peru, formaldehyde, quaternium-15, primin, tixocortol-21-pivalate, fragrance mix-2. Conclusion: In comparison of this study which first reports patch test results of patients in Tekirdağ-a city in Trakya region and other studies that report patch test results of different regions of our country; the mean age of patients of present study were older and there were similar results for occupations and localization of disease in between eastern region and present study. We believe that further studies are needed to specify allergen characteristics of Trakya region using multicenter studies, which include other cities as well.

  1. Positive patch test reactions in older individuals: retrospective analysis from the North American Contact Dermatitis Group, 1994-2008.

    Science.gov (United States)

    Warshaw, Erin M; Raju, Srihari I; Fowler, Joseph F; Maibach, Howard I; Belsito, Donald V; Zug, Kathryn A; Rietschel, Robert L; Taylor, James S; Mathias, C G Toby; Fransway, Anthony F; DeLeo, Vincent A; Marks, James G; Storrs, Frances J; Pratt, Melanie D; Sasseville, Denis

    2012-02-01

    Relatively little is known about the epidemiology of allergic contact dermatitis in older individuals. We sought to determine the frequency of positive and clinically relevant patch test reactions in older individuals (≥ 65 years old) referred for patch testing, and to compare these results with those of adults (≤ 64-19 years) and children (methyldibromo glutaronitrile, methyldibromo glutaronitrile/phenoxyethanol, ethyleneurea melamine formaldehyde mix, and carba mix (P values < .0004). Patch test reaction rates that were significantly lower in older individuals than both comparison groups included: nickel, thimerosal, and cobalt (P values < .0001). Referral population was a limitation. Older individuals were more likely to have at least one positive patch test reaction as compared with children, but had similar rates to adults. The frequency of positive reactions to specific allergens differed by age group, most likely as a result of exposures. Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

  2. EX1101: Ship Shakedown and Patch Tests on NOAA Ship Okeanos Explorer between March 16 and April 1, 2011

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This project will involve the shakedown of all Okeanos Explorer ship capabilities and a patch test of the Kongsberg EM302 multibeam system. Operations for this...

  3. Patch testing with markers of fragrance contact allergy. Do clinical tests correspond to patients' self-reported problems?

    DEFF Research Database (Denmark)

    Johansen, J D; Andersen, T F; Veien, N;

    1997-01-01

    in a questionnaire prior to patch testing with the European standard series. The questionnaire contained questions about skin symptoms from the use of scented and unscented products as well as skin reactions from contact with spices, flowers and citrus fruits that could indicate fragrance sensitivity. A highly...... of Peru balsam in detecting relevant fragrance contact allergy is limited, while most fragrance mix-positive patients are aware that the use of scented products may cause skin problems....

  4. Patch testing with markers of fragrance contact allergy. Do clinical tests correspond to patients' self-reported problems?

    DEFF Research Database (Denmark)

    Johansen, J D; Andersen, T F; Veien, Niels

    1997-01-01

    The aim of the present study was to investigate the relationship between patients' own recognition of skin problems using consumer products and the results of patch testing with markers of fragrance sensitization. Eight hundred and eighty-four consecutive eczema patients, 18-69 years of age, fill...... of Peru balsam in detecting relevant fragrance contact allergy is limited, while most fragrance mix-positive patients are aware that the use of scented products may cause skin problems....

  5. Multicenter Patch Testing With Methylchloroisothizoline/Methylisothiazolinone in 100 and 200 ppm Within the International Contact Dermatitis Research Group

    DEFF Research Database (Denmark)

    Engfeldt, Malin; Ale, Iris; Andersen, Klaus E

    2017-01-01

    on literature reviews, it was recommended that the concentration of 0.02% aq. should be used in the international baseline series. OBJECTIVES: The aim of this study was to verify the recommendation from 2011 by comparing the patch test results from consecutive patch testing with MCI/MI 0.01% and 0...... in more adverse reactions. Methylchloroisothiazolinone/MI at 0.02% aq. should therefore be continuously used in the international baseline series....

  6. Metal hypersensitivity reactions to implants: opinions and practices of patch testing dermatologists.

    Science.gov (United States)

    Schalock, Peter C; Thyssen, Jacob P

    2013-01-01

    Cutaneous metal hypersensitivity reactions (MHR) are common but rare with implanted devices. This study aimed to characterize the opinions of dermatologists who are actively evaluating/advising patients with MHR. A questionnaire was distributed to all individuals who attended the European Society of Contact Dermatitis (ESCD) 2012 and the American Contact Dermatitis Society 2013 meetings. A total of 119 individuals responded with a participation rates of 10% (ESCD) and 32% (American Contact Dermatitis Society). Ninety-six percent of the respondents evaluate MHR and 91% were attending physicians. Orthopedic and dental devices were common problems compared with cardiovascular devices. Patch testing is the top choice for evaluating MHR. Lymphocyte transformation and intradermal tests are rarely used. Eighty-two percent of the respondents evaluate plastic/glue components in symptomatic patients postimplant. Most dermatologists use a tray specifically for joint allergy or a history-based custom array of allergens. Those patients with a strong clinical history of metal allergy should be evaluated before metal implantation (54%), whereas others forgo evaluation and recommend a titanium implant based on history alone (38%). Diagnostic criteria for postimplant reactions were evaluated. Eight percent of the respondents felt that no evaluation was necessary, with ESCD respondents being significantly more likely to not recommend evaluation (P = 0.001). Metal hypersensitivity reactions consultation requests are common for preimplant and postimplant issues. Patch testing is currently the best test for MHR.

  7. Patch-test results in children and adolescents: systematic review of a 15-year period.

    Science.gov (United States)

    Rodrigues, Dulcilea Ferraz; Goulart, Eugênio Marcos Andrade

    2016-01-01

    The number of studies on patch-test results in children and adolescents has gradually increased in recent years, thus stimulating reviews. This paper is a systematic review of a 15-year period devoted to studying the issue. Variations pertaining to the number and age groups of tested children and/or adolescents, the number of subjects with atopy/atopic dermatitis history, the quantity, type and concentrations of the tested substances, the test technique and type of data regarding clinical relevance, must all be considered in evaluating these studies, as they make it harder to formulate conclusions. The most common allergens in children were nickel, thimerosal, cobalt, fragrance, lanolin and neomycin. In adolescents, they were nickel, thimerosal, cobalt, fragrance, potassium dichromate, and Myroxylon pereirae. Knowledge of this matter aids health professionals in planning preventive programs aimed at improving children's quality of life and ensuring that their future prospects are not undermined.

  8. Evaluation of patients with oral lichenoid lesions by dental patch testing and results of removal of the dental restoration material

    OpenAIRE

    Emine Buket Şahin; Fatma Çetinözman; Nihal Avcu; Ayşen Karaduman

    2016-01-01

    Background and Design: Oral lichenoid lesions (OLL) are contact stomatitis characterized by white reticular or erosive patches, plaque-like lesions that are clinically and histopathologically indistinguishable from oral lichen planus (OLP). Amalgam dental fillings and dental restoration materials are among the etiologic agents. In the present study, it was aimed to evaluate the standard and dental series patch tests in patients with OLL in comparison to a control group and evaluate our result...

  9. Immunophenotyping of the cutaneous cellular infiltrate after atopy patch testing in cats with atopic dermatitis.

    Science.gov (United States)

    Roosje, P J; Thepen, T; Rutten, V P M G; van den Brom, W E; Bruijnzeel-Koomen, C A F M; Willemse, T

    2004-10-01

    Cats with spontaneously occurring atopic dermatitis have clinical and immunocytochemical characteristics compatible with these in humans with atopic dermatitis (AD). The atopy patch test (APT) has proven to be a valuable tool in elucidating the disease process in humans. Additionally, the APT is very specific and bypasses the problem of conflicting results due to differences in chronicity of lesions of AD patients. We adapted the APT for use in cats to explore the suitability of the APT as a tool to study the onset of allergic inflammation in cats with atopic dermatitis. APT were performed in AD cats (n = 6) and healthy cats (n = 10). All cats were patch tested with two allergens in three different dilutions and a diluent control. The allergens for the APT were selected from positive intradermal test and /or prick test results and consisted of: Dermatophagoides farinae, D. pteronyssinus, Tyrophagus putrescentiae, and a grass pollen mixture. APT were read after 10, 24 and 48 h, and punch biopsies for immunohistochemical evaluation were collected at these time points. Macroscopically positive APT reactions were observed in three out of six cats at 24 and/or 48 h with allergen concentrations of 25,000 and 100,000 NU/ml. Reactions were not observed at negative control sites and neither in control animals. A significantly increased number of IL-4+, CD4+, CD3+, MHC class II+ and CD1a+ cells was found in one AD cat with positive APT reactions. Five out of six AD cats had significantly increased IL-4+ T cell numbers at 24 and/or 48 h. Our data indicate that in cats, macroscopically positive patch test reactions can be induced, which have a cellular infiltrate similar to that in lesional skin. We found a high specificity and a macroscopically positive APT reaction in half of the cats, which is similar to what is seen in humans. Hence, the APT in cats might be a useful tool in studying the immunopathogenesis of feline atopic dermatitis.

  10. Ethosome formulation of contact allergens may enhance patch test reactions in patients

    DEFF Research Database (Denmark)

    Madsen, Jakob Torp; Vogel, Stefan; Karlberg, Ann-Therese;

    2010-01-01

    Background: Ethosomes and liposomes are ultra-small vesicles capable of encapsulating drugs and cosmetic ingredients for topical use, thereby potentially increasing bioavailability and clinical efficacy. So far, few reports have suggested that formulation of cosmetic ingredients in vesicular......, a repeated open application test (ROAT) was performed in a subset of 16 patients, and lag time until a positive response was recorded. Results: Both contact allergens encapsulated in ethosomes showed significantly enhanced patch test reactions as compared with the allergen preparation in ethanol....../water without ethosomes. No significant difference in the median lag time was recorded between preparations in the ROAT. Conclusions: Encapsulating potential contact allergens in ethosomes may increase the challenge response as compared with the same concentrations in an ethanol/water base without ethosomes....

  11. Contact sensitization in venous eczema: Preliminary results of patch testing with Indian standard series and topical medicaments

    Directory of Open Access Journals (Sweden)

    Jindal Rashmi

    2009-01-01

    Full Text Available Background and Aims: Elimination of allergens/topical medications causing contact dermatitis in venous eczema, which poses a significant problem in its chronicity and treatment, provides the basis for better therapeutic outcome. Our objective was to determine the pattern of contact sensitization in venous eczema patients in Himachal Pradesh (India. Methods: Thirty-four patients (M:F, 31:3 and 10 controls (M:F, 6:4 were patch tested with Indian standard series and 10 commonly used topical medicaments. Results: Positive patch test results were seen in 50% (M:F, 16:1 of the patients. Common allergens were Fragrance mix (15%, p-phenylendiamine (15%, nickel (9%, wool alcohol (9%, chinoform (9%, balsum of Peru (5%, cobalt chloride (5%, potassium dichromate (3%, epoxy resin (3%, thiuram mix (3% and formaldehyde (3%. Only sisomycin and miconazole among the topical medications elicited a positive patch test reaction in 3 and 5% patients, respectively. Neomycin contact sensitivity was not seen in any of the patients. One patient who had exacerbation of venous eczema following accidental application of topical diclofenac showed a positive patch test reaction to it. Conclusions: Patch test should be used to identify the topical agents that may be responsible for perpetuation or aggravation of eczema, especially in patients who do not improve despite adequate treatment of other underlying cause(s.

  12. Can exposure limitations for well-known contact allergens be simplified? An analysis of dose-response patch test data.

    Science.gov (United States)

    Fischer, Louise Arup; Menné, Torkil; Voelund, Aage; Johansen, Jeanne Duus

    2011-06-01

    Allergic contact dermatitis is triggered by chemicals in the environment. Primary prevention is aimed at minimizing the risk of induction, whereas secondary and tertiary prevention are aimed at reducing elicitation. To identify the elicitation doses that will elicit an allergic reaction in 10% of allergic individuals under patch test conditions (ED(10) patch test) for different allergens, and to compare the results with those for different allergens and with animal data indicating sensitizing potency from the literature. The literature was searched for patch test elicitation studies that fulfilled six selected criteria. The elicitation doses were calculated, and fitted dose-response curves were drawn. Sixteen studies with eight different allergens-methylchloroisothiazolinone/ methylisothiazolinone, formaldehyde, nickel, cobalt, chromium, isoeugenol, hydroxyiso hexyl 3-cyclohexene carboxaldehyde, and methyldibromo glutaronitrile-were selected. The median ED(10) value was 0.835 µg/cm(2). The ED(10) patch test values were all within a factor of 7 from the lowest to the highest value, leaving out three outliers. No obvious patterns between the sensitization and elicitation doses for the allergens were found. We found a rather small variation in the ED(10) patch test between the allergens, and no clear relationship between induction potency and elicitation threshold of a range of allergens. This knowledge may stimulate thoughts on introducing a generic approach for limitations in exposure to well-known allergens. © 2011 John Wiley & Sons A/S.

  13. Compositae dermatitis in a Danish dermatology department in one year (I). Results of routine patch testing with the sesquiterpene lactone mix supplemented with aimed patch testing with extracts and sesquiterpene lactones of Compositae plants

    DEFF Research Database (Denmark)

    Paulsen, E; Andersen, Klaus Ejner; Hausen, B M

    1993-01-01

    of standard, photo- and other plant patch tests are presented. The only partial overlap between positive reactions to the mixes emphasizes the necessity of supplementary testing in patients suspected of Compositae allergy, as well as the lack of a reliable single screening agent. Since no cases of active...

  14. Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG).

    Science.gov (United States)

    Geier, Johannes; Lessmann, Holger; Dickel, Heinrich; Frosch, Peter J; Koch, Patrick; Becker, Detlef; Jappe, Uta; Aberer, Werner; Schnuch, Axel; Uter, Wolfgang

    2004-09-01

    Based on the information of the interdisciplinary task force on allergy diagnostics in the metal branch, in 2001, the German Contact Dermatitis Research Group (DKG) compiled two metalworking fluid (MWF) test series with currently and previously used components, respectively. After 2 years of patch testing, we present results obtained with these series, based on data of the Information Network of Departments of Dermatology (IVDK). 251 metalworkers who were patch tested because of suspected MWF dermatitis in 2002 and 2003 were included in this retrospective data analysis. Of these, 206 were tested with the current MWF series and 155 with the historical MWF series. Among the current MWF allergens, monoethanolamine ranked 1st with 11.6% positive reactions. Diethanolamine (3.0%), triethanolamine (1.1%), and diglycolamine (1.9%) elicited positive reactions far less frequently. Allergic reactions to p-aminoazobenzene were frequently observed (6.0%), but the relevance of these reactions is still obscure. Positive reactions to biocides ranged from 4.5% for Bioban CS 1135 to 0.5% for iodopropynyl butylcarbamate and 2-phenoxyethanol. Concomitant reactions to formaldehyde, which caused positive reactions in 3.3%, and formaldehyde releasers occurred to varying extents without conclusive pattern. No positive reactions were seen to dibutyl phthalate, di-2-ethylhexyl phthalate, tricresyl phosphate, isopropyl myristate or benzotriazole. With the historical MWF test series, positive reactions to methyldibromo glutaronitrile (MDBGN) were observed most frequently. However, sensitization via allergen sources other than MWF seems likely, as MDBGN, during the study period, has been one of the most frequent preservative allergens in cosmetics and body care products. Other historical MWF allergens comprised morpholinyl mercaptobenzothiazole (3.3%), benzisothiazolinone (BIT; 2.0%) and Bioban P 1487(1.3%). BIT is currently used in MWF again, so it was shifted to the current MWF test series

  15. Sites of dermatitis in a patch test population: hand dermatitis is associated with polysensitization

    DEFF Research Database (Denmark)

    Carlsen, B C; Andersen, K E; Menné, T

    2009-01-01

    . METHODS: A matched case-control study was carried out including 394 polysensitized and 726 single/double-sensitized patients who responded to a postal questionnaire. All subjects were recruited from a hospital patch test population. RESULTS: The hands were the most frequent and the anogenital region...... was the least frequent skin area affected with dermatitis. Dermatitis on the hands/wrists [odds ratio (OR) 1.58], in the armpits (OR 1.56) and on the back (OR 1.91) was positively associated with polysensitization. The hands were the only skin area with dermatitis which maintained the association...... compared with single/double-sensitized patients. CONCLUSIONS: Special awareness in patients with hand dermatitis seems justified either to prevent development of multiple contact allergies or to document polysensitization as an aetiological factor....

  16. One point quadrature shell elements: a study on convergence and patch tests

    Science.gov (United States)

    Cardoso, Rui P. R.; Yoon, Jeong-Whan

    2007-10-01

    One point quadrature shell elements are being widely used in the numerical simulation of shell structures, including sheet forming, because essentially of their computational efficiency. Nowadays, the purpose of using one point quadrature shell elements is not only related to computational efficiency but also because these elements have shown to be simultaneously robust and accurate in the simulation of complex sheet metal forming processes. The main objective of this work is to study the convergence behavior of different one-point quadrature shell elements and their ability to pass the membrane and bending patch tests. For comparison purposes, two new elements include a new formulation for the membrane strain field in order to further improve the membrane behavior of the element developed in previous work of (in Cardoso et al. Comput Meth Appl Mech Eng 191:5177, 2002). The original convective membrane strains of Cardoso et al. (Comput Meth Appl Mech Eng 191:5177, 2002) (in the stabilization matrices only) are thus replaced by new membrane strains, constructed directly at the co-rotational coordinate system (located at the element’s center). It is thus proved that with this new membrane formulation the elements pass now all the patch tests but, for warped (or curved) element geometries, their accuracy is not as good as the original element of (Cardoso et al. in Comput Meth Appl Mech Eng 191:5177, 2002) based on the convective coordinate system. In the numerical results presented in this paper, comprehensive comparison and discussion of these formulations are made for well known linear benchmark examples.

  17. Patch testing with a new fragrance mix detects additional patients sensitive to perfumes and missed by the current fragrance mix

    DEFF Research Database (Denmark)

    Frosch, Peter J; Pirker, Claudia; Rastogi, Suresh C

    2005-01-01

    The currently used 8% fragrance mix (FM I) does not identify all patients with a positive history of adverse reactions to fragrances. A new FM II with 6 frequently used chemicals was evaluated in 1701 consecutive patients patch tested in 6 dermatological centres in Europe. FM II was tested in 3 c...

  18. Oxybutynin Transdermal Patch

    Science.gov (United States)

    ... clothing, and where it will be protected from sunlight by clothing. After you apply a patch to ... stomach extreme tiredness drowsiness headache blurred vision flushing back pain Some side effects can be serious. The following ...

  19. Course of contact allergy in consecutive eczema patients patch tested with TRUE Test panels 1 and 2 at least twice over a 12-year period

    DEFF Research Database (Denmark)

    Jensen, Charlotte D; Andersen, Klaus E

    2005-01-01

    -year period using the TRUE Test standardized patch test system. Out of 297 positive reactions, 66% remained positive in a 2nd test, 10% were scored as doubtful and 24% as negative. Among the previously recorded doubtful reactions, 13% were positive in the 2nd test, 13% were again doubtful and 74...... on the back and the presence of more or less active dermatitis....

  20. Reliability of a New Lower-Extremity Motor Coordination Test

    Directory of Open Access Journals (Sweden)

    Antosiak-Cyrak Katarzyna

    2015-12-01

    Full Text Available Introduction. Motor coordination is a basic motor ability necessary for daily life, which also allows athletes to win a sports rivalry and patients to assess their recovery progress after therapy and rehabilitation. The aim of the present study was to assess the reliability of a new lower-extremity rate of movements test and testing apparatus.

  1. Characteristics of patients patch tested in the European Surveillance System on Contact Allergies (ESSCA) network, 2009-2012

    NARCIS (Netherlands)

    Uter, Wolfgang; Gefeller, Olaf; Gimenez-Arnau, Ana; Frosch, Peter; Johansen, Jeanne Duus; Schuttelaar, Marie-Louise; Rustemeyer, Thomas; Filon, Francesca Larese; Dugonik, Aleksandra; Bircher, Andreas; Wilkinson, Mark

    2015-01-01

    BackgroundPatch test results often vary between departments, and also between countries. Such variation may be partly attributable to systematic effects introduced by patient characteristics, differing exposures, patient selection, or methodological differences. ObjectiveTo examine the amount of var

  2. Multicenter Patch Testing With a Resol Resin Based on Phenol and Formaldehyde Within the International Contact Dermatitis Research Group

    DEFF Research Database (Denmark)

    Isaksson, M.; Ale, I.; Andersen, Klaus Ejner

    2015-01-01

    Background Contact allergy to phenol-formaldehyde resins (PFRs) based on phenol and formaldehyde is not detected by a p-tertiary-butylphenol-formaldehyde resin included in most baseline patch test series. Objective The aims of this study were to investigate the contact allergy rate to PFR-2...

  3. Allergy to tea tree oil: retrospective review of 41 cases with positive patch tests over 4.5 years.

    Science.gov (United States)

    Rutherford, Tim; Nixon, Rosemary; Tam, Mei; Tate, Bruce

    2007-05-01

    Tea tree oil use is increasing, with considerable interest in it being a 'natural' antimicrobial. It is found in many commercially available skin and hair care products in Australia. We retrospectively reviewed our patch test data at the Skin and Cancer Foundation Victoria over a 4.5-year period and identified 41 cases of positive reactions to oxidized tea tree oil of 2320 people patch-tested, giving a prevalence of 1.8%. The tea tree oil reaction was deemed relevant to the presenting dermatitis in 17 of 41 (41%) patients. Of those with positive reactions, 27 of 41 (66%) recalled prior use of tea tree oil and eight of 41 (20%) specified prior application of neat (100%) tea tree oil. Tea tree oil allergic contact dermatitis is under-reported in the literature but is sufficiently common in Australia to warrant inclusion of tea tree oil, at a concentration of 10% in petrolatum, in standard patch-test series. Given tea tree oil from freshly opened tea tree oil products elicits no or weak reactions, oxidized tea tree oil should be used for patch testing.

  4. Additive value of patch testing custom epoxy materials from the workplace at the occupational disease specialty clinic in Toronto.

    Science.gov (United States)

    Houle, Marie-Claude; Holness, D Linn; Dekoven, Joel; Skotnicki, Sandy

    2012-01-01

    Allergic contact dermatitis (ACD) to epoxy resins is one of the major causes of occupationally induced ACD. Testing of custom epoxy materials from the workplace is often performed to diagnose ACD. The objective of this study was to investigate the additive value of patch testing custom-made epoxy materials. We retrospectively analyzed outcomes of 24 patients who were tested to custom epoxy resin materials between January 2002 and July 2011. For 11 patients (46%), the testing of their materials from work had no additional value (negative results). For 13 patients (54%), there was an additional value of testing custom allergens. Of those, 7 patients (54%) had positive reactions to custom epoxy materials that reinforced the test results found with the commercially available allergens, and 6 (46%) patients had positive reactions only to custom epoxy materials. Therefore, for 6 patients (25%), there was a definite additive value of testing custom epoxy materials because the allergy was discovered with custom testing and not with the commercially available allergens. Because of the high percentage (54%) of patients with additive value of patch testing custom epoxy materials, we think that the inclusion of actual workplace epoxy materials should be strongly considered when patch testing patients with occupational epoxy exposure.

  5. Patch testing with preservatives at St John's from 1982 to 1993.

    Science.gov (United States)

    Jacobs, M C; White, I R; Rycroft, R J; Taub, N

    1995-10-01

    We have reviewed our patch test results for preservative allergy from 1982 to 1993. 8 preservatives were included: formaldehyde, 2-bromo-2-nitropropane-1,3-diol (Bronopol(TM)), quaternium-15 (Dowicil 200TM), imidazolidinyl urea (Germall 115TM), diazolidinyl urea (Germall IITM), parabens, 5-chloro-2methyl-isothiazolin-3-one (Kathon CG(TM)) and 1,2-dibromo-2,4-dicyanobutane (one of the constituents of Euxyl K 400TM). Whereas the allergy rate to formaldehyde is quite stable, there is a slight increase in the imidazolidinyl urea allergy rate. Quaternium-15's rate is decreasing and 5-chloro-2-methyl-isothiazolin-3-one plus 2-methyl-isothiazolin-3-one's rate, after a rapid rise, seems to have stabilized. Although very important constituents of cosmetics, preservatives not only induce allergies on the face but also on the hands, and, as expected, the allergy rate in men and women generally differs. Among the 5 formaldehyde-releasers, there are some favoured simultaneous reactions: quaternium-15 and formaldehyde, and diazolidinyl urea and imidazolidinyl urea. Concomitant reactions between 1-bromo-2-nitropropane-1,3-diol and formaldehyde are not common, and those between 2-bromo-2-nitropropane-1,3-diol and diazolidinyl urea, and formaldehyde are not very common. This supports the hypothesis that allergic reactions to the Germalls are directed toward the initial molecule rather than to formaldehyde.

  6. Survey of Occupational Allergic Contact Dermatitis and Patch Test among Clothing Employees in Beijing

    Science.gov (United States)

    Chen, Yu-Xin; Gao, Bing-Ai; Cheng, Hai-Yan

    2017-01-01

    Occupational population-based epidemiological data relating to occupational contact allergies in the Chinese clothing industry are limited. To investigate the prevalence of occupational allergic contact dermatitis (OACD) and to identify the causative allergens among clothing employees in China, a cross-sectional study was conducted in 529 clothing employees at 12 clothing factories in Beijing. All employees were subjected to an interview using self-administered questionnaire and skin examination, and those who were diagnosed with occupational contact dermatitis (OCD) were patch tested. In the present survey, we found that the overall 1-year prevalence of OACD among the clothing employees was 8.5%. The 1-year prevalence of OACD among workers (10.8%) was significantly higher than that among managers (3.2%). The lesions were primarily on the hands and wrists in workers, but the face and neck in managers. The major allergens were nickel sulfate and cobalt dichloride in workers and colophony and p-tert-butylphenol formaldehyde resin in managers. In conclusion, workers are at a higher risk of OACD compared with managers in the Chinese clothing industry. In addition to hand dermatitis in workers, airborne contact dermatitis on the face and neck should be also addressed in managers.

  7. European Standard Series patch test results from a contact dermatitis clinic in Israel during the 7-year period from 1998 to 2004.

    Science.gov (United States)

    Lazarov, Aneta

    2006-08-01

    The results of a 7-year retrospective study (1998-2004) from patch testing with the European Standard Series (ESS) establishing the frequency of sensitization in a contact dermatitis clinic in Israel are presented. 23 allergens were patch tested on 2156 patients, 1462 females (67.8%) and 694 males (32.2%). Atopy and asthma were present in 21.9% of the patients. One or more allergic reactions were observed in 937 patients (43.5%). The highest yield of patch test positives from the 1076 positive reactions were obtained from nickel sulfate (13.9%), fragrance mix (7.1%), potassium dichromate (3.8%), Balsam of Peru (3.6%), CL+Me-isothiazolinone (3.4%) and cobalt chloride (3.4%). Allergens which produced the least amount of positive results were primin and clioquinol. Allergic contact dermatitis (ACD) was established in 32.8%, whereas occupationally related allergic (8.0) and irritant contact dermatitis (5.6%) affected a total of 13.6% of the cases studied. The most common clinical forms of dermatitis were chronic dermatitis (47.7%) followed by acute dermatitis (22.8%), and lichenification and hyperkeratosis (7.9%). The hands (30.7%), face and neck (23.9%) and extremities (11.3%) were the most frequently affected areas. Four allergens in our study differed from the top 10 allergens in Europe namely: Cl+Me-isothiazolinone, formaldehyde, 4-tert-butylphenol formaldehyde resin and sesquiterpene lactone mix reflecting an existing difference in environmental exposure. Our study is the first to provide data on the frequency of sensitization and important allergens in the aetiology of ACD in Israel. In spite of the existing differences with Europe, we conclude that ESS is an appropriate screening system for the diagnosis of ACD in Israel.

  8. Patch Testing for Evaluation of Hypersensitivity to Implanted Metal Devices: A Perspective From the American Contact Dermatitis Society.

    Science.gov (United States)

    Schalock, Peter C; Crawford, Glen; Nedorost, Susan; Scheinman, Pamela L; Atwater, Amber Reck; Mowad, Christen; Brod, Bruce; Ehrlich, Alison; Watsky, Kalman L; Sasseville, Denis; Silvestri, Dianne; Worobec, Sophie M; Elliott, John F; Honari, Golara; Powell, Douglas L; Taylor, James; DeKoven, Joel

    2016-01-01

    The American Contact Dermatitis Society recognizes the interest in the evaluation and management of metal hypersensitivity reactions. Given the paucity of robust evidence with which to guide our practices, we provide reasonable evidence and expert opinion-based guidelines for clinicians with regard to metal hypersensitivity reaction testing and patient management. Routine preoperative evaluation in individuals with no history of adverse cutaneous reactions to metals or history of previous implant-related adverse events is not necessary. Patients with a clear self-reported history of metal reactions should be evaluated by patch testing before device implant. Patch testing is only 1 element in the assessment of causation in those with postimplantation morbidity. Metal exposure from the implanted device can cause sensitization, but a positive metal test does not prove symptom causality. The decision to replace an implanted device must include an assessment of all clinical factors and a thorough risk-benefit analysis by the treating physician(s) and patient.

  9. Modulation of atopy patch test reactions by topical treatment of human skin with a fatty acid-rich emollient.

    Science.gov (United States)

    Billmann-Eberwein, C; Rippke, F; Ruzicka, T; Krutmann, J

    2002-01-01

    Measures directed at improving the skin barrier function are thought to be effective in preventing reexacerbation of atopic dermatitis, but direct proof of a prophylactic effect of emollients has been elusive. In the present study, the atopy patch test has been employed as a model for the initiation phase of atopic dermatitis in order to assess whether pretreatment of non-lesional skin with a fatty acid-rich emollient (Eucerin Omega Creme) has a prophylactic effect in patients with atopic dermatitis. Pretreatment of test sites with Eucerin Omega Creme either prevented or diminished the development of eczema, as compared with untreated control test sites in the same patients (n = 38). These studies indicate that the use of fatty acid-rich emollients prevents the development of atopic eczema. They also demonstrate that the atopy patch test can be used to assess the capacity of a given regimen to exert prophylactic effects in this disease. Copyright 2002 S. Karger AG, Basel

  10. Nickel allergy in patch-tested female hairdressers and assessment of nickel release from hairdressers' scissors and crochet hooks

    DEFF Research Database (Denmark)

    Thyssen, Jacob Pontoppidan; Milting, Kristina; Bregnhøj, Anne;

    2009-01-01

    BACKGROUND: Hand eczema as well as nickel contact allergy is prevalent among hairdressers. Recently, two female hairdressers were diagnosed with nickel contact allergy-related hand eczema following prolonged skin contact with scissors and crochet hooks used during work. OBJECTIVES: To determine...... the proportion of hairdressers' scissors and crochet hooks that released an excessive amount of nickel and to determine the prevalence of nickel allergy among patch-tested female hairdressers. MATERIALS: Random hairdressers' stores in Copenhagen were visited. The dimethylglyoxime (DMG) test was used to assess...... excessive nickel release. The prevalence of nickel allergy among female hairdressers from the database at Gentofte Hospital was compared with the prevalence of nickel allergy among other consecutively patch-tested dermatitis patients. RESULTS: DMG testing showed that 1 (0.5%; 95% CI = 0 - 2.0) of 200 pairs...

  11. The impact of meteorological conditions on patch test results with 12 standard series allergens (fragrances, biocides, topical ingredients).

    Science.gov (United States)

    Uter, W; Hegewald, J; Kränke, B; Schnuch, A; Gefeller, O; Pfahlberg, A

    2008-04-01

    Fluctuating irritability of the skin induced by low ambient temperature and humidity may compromise the reproducibility of patch testing. To assess the impact of temperature and absolute humidity at the time of patch testing on the occurrence of irritant or doubtful (IR/?), weak positive (+) and (strong) positive (++/+++) reactions, respectively, among 12 allergens included in the German Standard Series. Analysis of clinical data collected in the surveillance network IVDK (http://www.ivdk.org) between January 1993 and December 2001 (n = 73 691 patients) combined with meteorological data obtained by the national services in Germany and Austria. Multinomial logistic regression analysis was used to estimate the risk associated with temperature, absolute humidity and vapour pressure, respectively, adjusted for sex, age, atopic dermatitis and duration of patch test application. For low temperature and humidity, a relevant increase of IR/? reaction frequency was observed in the cases of paraben mix and (chloro-) methylisothiazolinone. Both IR/? and + reactions were significantly increased with respect to the allergens fragrance mix, oil of turpentine, methyldibromo glutaronitrile + phenoxyethanol and particularly formaldehyde, while ++/+++ reactions were hardly affected by weather conditions. The observed increase of IR/? reactions may be due to epidermal barrier function impairment. The impact of dry/cold weather on + reactions in terms of possibly false-positive reactions is restricted to few allergens. In the case of + reactions of unknown relevance, a re-test under warm conditions or verification tests such as the repeated open application test or the provocative use test may be recommendable.

  12. Conceptual Design Report for the Extreme Ecosystems Test Chambers

    Energy Technology Data Exchange (ETDEWEB)

    C. Barnes; J. Beller; K. Caldwell; K. Croft; R. Cherry; W. Landman

    1998-12-01

    This conceptual design supports the creation of Extreme Ecosystems Test Chambers, which will replicate deep subsurface and subocean environments characterized by high pressure (2,000 psi) and subfreezing to high temperature (-4 to 300 degrees F) with differing chemical and saturation conditions. The design provides a system to support research and development that includes heat transfer, phase change issues in porous media, microbiology in extreme environments, and carbon sequestration and extraction. The initial system design is based on the research needs to support the commercial production of methane hydrates from subsurface sediments. The design provides for three pressure vessels: a Down Hole Test Vessel, a Vertical Multi-phase Test Vessel, and a Horizontal Multi-phase Test Vessel.

  13. Las pruebas epicutáneas de contacto en medicina laboral Patch testing in occupational medicine

    Directory of Open Access Journals (Sweden)

    Carolina Granados Rincón

    2013-03-01

    Full Text Available Dentro de la Medicina Laboral las dermatosis ocupacionales suponen entre el 30-60% del total de enfermedades profesionales y, dentro de ellas el 80-90% son dermatitis de contacto. Este alto número no se ve reflejado en datos oficiales debido a que en muchas ocasiones, al ser condiciones de rápida resolución o de escasa repercusión sistémica, no son declaradas. En relación a las dermatitis de contacto, la forma más frecuente en el entorno laboral es la forma alérgica y la que preferentemente se declara, al ser un proceso que en muchas ocasiones constituye motivo de incapacidad. Para el abordaje diagnóstico y correspondiente asociación con el entorno de trabajo es imprescindible realizar una historia clínica laboral completa junto con la descripción de las lesiones, y la utilización de métodos diagnósticos distintos a los de otros procesos no cutáneos, como son las pruebas de parche (patch test o pruebas epicutáneas. Constituyen un método simple, accesible y seguro para llegar al diagnóstico de las dermatitis alérgicas de contacto. Incluyen una batería estándar, propia de un país donde se trabaja, ampliada de baterías específicas en relación con el perfil, las tareas y los productos manipulados por el trabajador. La prevención en el trabajo es el único tratamiento etiológico para la sustitución y control de los riesgos laborales relacionados con las dermatosis profesionales.In occupational medicine, occupational dermatoses account for 30 to 60% of the total amount of occupational diseases and, within 80 to 90% of them correspond to contact dermatitis. This high number is not reflected in official data because in most cases, as conditions of rapid resolution or low systemic impact, they are not declared. Regarding contact dermatitis, the most common type in the workplace is the allergic type, which preferably is declared, because often results in disability. For the correct diagnosis and association with the work

  14. [Results of patch test in hairdressers examined in the institute of occupational medicine in Łódź].

    Science.gov (United States)

    Kieć-Swierczyńska, Marta; Krecisz, Beata; Chomiczewska, Dorota

    2009-01-01

    Occupational contact dermatitis is a significant health problem in hairdressers. The number of occupational skin diseases in this group constantly increases. The most frequent factors contributing to the skin damage include water, shampoos, detergents, conditioners, hair dyes, bleaches, permanent wave solutions, and components of gloves. A group of 121 hairdressers (106 women and 6 men) was selected from 4523 patients (2996 women and 1527 men) referred to the Nofer Institute of Occupational Medicine, Łódź, in 1995-2008, with suspected occupational skin disease. All hairdressers underwent dermatological examination and allergy tests (patch tests with allergens of the European Standard Series and Hairdressing Series, Chemotechnique Diagnostics, Sweden; skin prick tests, Allergopharma, Germany). Females were more prevalent than males and constituted 94.6% of the study group. Of all the study participants, 30% were trainee hairdressers. At least one positive patch test reaction was found in 69.7% of patients whereas in 30.3% patch tests were negative. The most frequent contact allergens were: nickel sulfate (40% of females), p-phenylenediamine (one fourth of the study group), ammonium persulfate (23.2%), cobalt chloride (21.4%), 2,5-diaminotoluene sulfate (9.8%), formaldehyde (9.8%), ammonium thioglycolate (7.1%), and glyceryl monothioglycolate (7.1%). Moreover, we found positive patch test reactions to thimerosal (14.3%), palladium chloride (11.6%), potassium dichromate (5.3%) and fragrance mix (4.5%). Altogether, occupational origin of skin disease was confirmed in 46.4% of hairdressers with allergic contact dermatitis, in 48.2% of those diagnosed with irritant contact dermatitis and in 0.9% of hairdressers suffering from urticaria. 71% of trainee hairdressers were finally diagnosed with allergic contact dermatitis, caused first of all by ammonium persulfate, p-phenylenediamine, nickel and thimerosal. In conclusion, it seems to be indispensable to implement health

  15. Preserved scleral patch graft for unexpected extreme scleral thinning found at the scleral buckling procedure: A case report

    Directory of Open Access Journals (Sweden)

    Spela Stunf

    2011-01-01

    Full Text Available Pre-existing scleral pathology is an important risk factor for globe rupture during scleral buckling procedures. We report here, the surgical management of an unexpected scleral pathology found at the scleral buckling procedure in a retinal detachment patient. A 77-year-old white female with retinal detachment underwent a scleral buckling procedure. The surgery was converted into a scleral graft procedure, as extreme scleral thinning was found intraoperatively. An alcohol-preserved donor sclera graft was used. The second surgery for definitive retinal alignment was performed two weeks later. The presented case of an unexpected scleral pathology in a retinal detachment patient was managed with a combination of scleral grafting and pars plana vitrectomy, without any major complications. The anatomical outcome was excellent and the scleral rupture was prevented; the visual outcome was satisfactory. A conversion of the scleral buckling procedure into a scleral graft procedure has proved to be safe and effective for unexpected scleral pathology.

  16. ESCD Guideline (2105) on Diagnostic Patch Testing%诊断性斑贴试验ESCD指南(2015)

    Institute of Scientific and Technical Information of China (English)

    李欣泽; 李全生; 姜启君; 魏庆宇

    2016-01-01

    2015年7月欧洲接触性皮炎学会(ESCD)发布了诊断性斑贴试验的最佳实施建议.指南中总结了所有怀疑患有变应性接触性皮炎或者皮肤和黏膜的迟发型过敏反应的接触性过敏的患者应用诊断性斑贴试验的各个方面.主要包括斑贴试验的定义、材料、技术、皮内测试的修订、影响斑贴试验结果或特殊情况、职业性接触性皮炎患者、药疹、斑贴试验的副作用、结果的评估、医疗教育等.下面就针对指南中的这些方面进行介绍.%European Society of Contact Dermatitis (ESCD) published a guideline on the recommendations of the best practice for diagnostic patch testing in July 2015.The new guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering or having been suffering from allergic contact dermatitis or other delayed-type hypersensitive skin and mucosal conditions.Main topics include the introduction of important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, patients with occupational contact dermatitis and drug eruptions, adverse effects of patch testing, final evaluation, and patient education.These aspects of the guildine will be introduced.

  17. Simultaneous patch testing with fragrance mix I, fragrance mix II and their ingredients in southern Sweden between 2009 and 2015.

    Science.gov (United States)

    Mowitz, Martin; Svedman, Cecilia; Zimerson, Erik; Isaksson, Marléne; Pontén, Ann; Bruze, Magnus

    2017-07-07

    Fragrance mix I (FM I) and fragrance mix II (FM II) are included in the European baseline series as screening substances for fragrance contact allergy. To investigate the frequency of allergic reactions to FM I, FM II and their ingredients in consecutively patch tested patients. A retrospective analysis of data from 4430 patients patch tested between 2009 and 2015 was performed. Of the patients, 6.5% were FM I-positive and 3.2% were FM II-positive. Forty-five per cent of FM I-positive patients did not have positive reactions to FM I ingredients. Thirty-five per cent of those who were FM II-positive did not have positive reactions to FM II ingredients. Twenty-seven per cent of those with positive reactions to one or more of the FM I ingredients were FM I-negative, and 36% of those who had positive reactions to one or more of the FM II ingredients were FM II-negative. The allergens with the highest pick-up rates were Evernia prunastri (1.8%), cinnamal (1.3%), citral (1.2%), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (1.2%). Significant differences were observed in the proportions of positive reactions to FM I, FM II, eugenol, isoeugenol, and farnesol when results from patch testing with materials from different suppliers were compared. There is a risk of missing fragrance contact allergy when testing with only the fragrance mixes is performed. The use of preparations from different suppliers may affect the patch test results. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  18. Patch Test Results with Standard and Cosmetic Series in Patients with Suspected Cosmetic-Induced Contact Dermatitis

    Directory of Open Access Journals (Sweden)

    Şenay Hacıoğlu

    2010-12-01

    Full Text Available Background and Design: Our aim was to evaluate the hypersensitivity to cosmetic chemicals in patients with clinically suspected cosmetic-induced contact dermatitis in Bursa and the South Marmara Region (Turkey by patch testing with standard and cosmetic series.Material and Method: Seventy-three patients with clinically suspected contact dermatitis due to cosmetics were patch tested by the European standard series and cosmetic series. The patch test results were analyzed as percentages. x2 test was used to demonstrate the relationship between cosmetic products and cosmetic allergens.Results: 90.4% of patients in our study group were female and 9.6% were male; the median age was 37.5 (range 16-71 years. The most commonly involved parts of the body were the face (49.3%, hands (16.4%, periocular region (6.8%, lips (6.8%, and the neck (5.5%. The most common offending cosmetic products causing allergic contact dermatitis were soaps and cleansing lotions (32.8%, moisturizer creams (21.9%, make-up (15.0%, and hair dyes (9.6%. 41.0% of patients showed positive reaction to at least one cosmetic allergen included in either standard or cosmetic series. The cosmetic allergens in the standard series and the rates of positivity were as follows: fragrance mix (6.8%, lanolin alcohols (5.5%, paraphenylenedaimine (2.7%, colophony (1.4%, paraben mix (1.4%, formaldehyde (1.4%, and methylchloroisothiazolinone (Kathon CG in descending order. The most common offending cosmetic allergen groups were preservatives (21.9%, antioxidants (8.2% and fragrances (6.8%. Conclusion: Allergic or irritant contact dermatitis due to cosmetics should be considered in cases of eczema involving face, neck, eyelids, lips, scalp or hands. Patch testing with cosmetic series beside standard series would be more helpful in detecting the responsible allergen(s.

  19. Patch test reactions to cosmetic allergens in 1995-1997 and 2000-2002 in Finland--a multicentre study.

    Science.gov (United States)

    Hasan, T; Rantanen, T; Alanko, K; Harvima, R J; Jolanki, R; Kalimo, K; Lahti, A; Lammintausta, K; Lauerma, A I; Laukkanen, A; Luukkaala, T; Riekki, R; Turjanmaa, K; Varjonen, E; Vuorela, A-M

    2005-07-01

    Contact sensitivity to cosmetics is common, but the sensitizing chemicals vary between countries and study periods. The present survey aimed at revealing the recent trends in patch test sensitivity with cosmetic chemicals in Finland. We report a retrospective multicentre survey of patch test reactions focusing on cosmetic-related substances and comparing the test results in 1995-97 with those in 2000-02. The most striking increases in the frequency of the patch test sensitivity were found with balsam of Peru and propolis from 4.0% to 6.2% (P methyldibromo glutaronitrile increased, although not significantly, from 1.0% to 1.5%. An increasing tendency was also found with hair dye chemicals 4-aminophenol and toluene-2,5-diamine or toluene-2,5-diamine sulfate from 1.3% to 3.8% and from 1.4% to 5.2%, respectively, while such a tendency was not found among permanent wave chemicals. The sensitivity level of fragrance mix remained the same (6% - 7%). We conclude that surveys revealing the state of sensitivity to cosmetic chemicals should be performed periodically in different countries.

  20. Modeling the Extremely Lightweight Zerodur Mirror (ELZM) Thermal Soak Test

    Science.gov (United States)

    Brooks, Thomas E.; Eng, Ron; Hull, Tony; Stahl, H. Philip

    2017-01-01

    Exoplanet science requires extreme wavefront stability (10 pm change/10 minutes), so every source of wavefront error (WFE) must be characterized in detail. This work illustrates the testing and characterization process that will be used to determine how much surface figure error (SFE) is produced by mirror substrate materials' CTE distributions. Schott's extremely lightweight Zerodur mirror (ELZM) was polished to a sphere, mounted, and tested at Marshall Space Flight Center (MSFC) in the X-Ray and Cryogenic Test Facility (XRCF). The test transitioned the mirror's temperature from an isothermal state at 292K to isothermal states at 275K, 250K and 230K to isolate the effects of the mirror's CTE distribution. The SFE was measured interferometrically at each temperature state and finite element analysis (FEA) has been completed to assess the predictability of the change in the mirror's surface due to a change in the mirror's temperature. The coefficient of thermal expansion (CTE) distribution in the ELZM is unknown, so the analysis has been correlated to the test data. The correlation process requires finding the sensitivity of SFE to a given CTE distribution in the mirror. A novel hand calculation is proposed to use these sensitivities to estimate thermally induced SFE. The correlation process was successful and is documented in this paper. The CTE map that produces the measured SFE is in line with the measured data of typical boules of Schott's Zerodur glass.

  1. A Coons Patch Spanning a Finite Number of Curves Tested for Variationally Minimizing Its Area

    Directory of Open Access Journals (Sweden)

    Daud Ahmad

    2013-01-01

    Full Text Available In surface modeling a surface frequently encountered is a Coons patch that is defined only for a boundary composed of four analytical curves. In this paper we extend the range of applicability of a Coons patch by telling how to write it for a boundary composed of an arbitrary number of boundary curves. We partition the curves in a clear and natural way into four groups and then join all the curves in each group into one analytic curve by using representations of the unit step function including one that is fully analytic. Having a well-parameterized surface, we do some calculations on it that are motivated by differential geometry but give a better optimized and possibly more smooth surface. For this, we use an ansatz consisting of the original surface plus a variational parameter multiplying the numerator part of its mean curvature function and minimize with the respect to it the rms mean curvature and decrease the area of the surface we generate. We do a complete numerical implementation for a boundary composed of five straight lines, that can model a string breaking, and get about 0.82 percent decrease of the area. Given the demonstrated ability of our optimization algorithm to reduce area by as much as 23 percent for a spanning surface not close of being a minimal surface, this much smaller fractional decrease suggests that the Coons patch we have been able to write is already close of being a minimal surface.

  2. Comparative assessment of the acute skin irritation potential of detergent formulations using a novel human 4-h patch test method.

    Science.gov (United States)

    Robinson, Michael K; Kruszewski, Francis H; Al-Atrash, Jenan; Blazka, Mark E; Gingell, Ralph; Heitfeld, Fred A; Mallon, David; Snyder, Neil K; Swanson, Judith E; Casterton, Phillip L

    2005-12-01

    Predictive skin irritation test methods, which do not require use of animals, are needed for the pre-market assessment of detergent formulations. The utility of a novel and ethical human acute skin irritation patch test method, originally developed for chemical skin irritation assessment, was evaluated. In this IRB-approved method, subjects were patched under occlusion for increasing periods of time up to 4h in duration. The total incidence of positive skin reactions for test products was compared to a positive control (20% aqueous sodium dodecyl sulfate [SDS]). Acutely irritating formulas were defined as those showing a significantly increased or equal incidence of positive responders compared with that of SDS. The time of exposure required for 50% of subjects to show a positive skin reaction (TR50 value) was calculated for each product and enabled test product comparisons within and between studies. Using this approach, 24 detergent formulations of various types were tested in seven individual studies. The skin irritation profiles were generally consistent within product types, which could be categorized as follows (by decreasing irritancy): mold/mildew removers (average TR50 = 0.37 h) > disinfectants/sanitizers (0.64 h) > fabric softener concentrate (1.09 h) = aluminum wash (1.20 h) > 20% SDS (1.81 h) > liquid laundry detergents (3.48 h) > liquid dish detergents (4.16 h) = liquid fabric softeners (4.56 h) = liquid hand soaps (4.58 h) = shampoos (5.40 h) = hard surface cleaners (6.34 h) > powder automatic dish detergents (>16 h) = powder laundry detergents (>16 h). In addition to formulation effects, some seasonal effects were noted; particularly greater winter-time reactivity to 20% SDS and the hard surface cleaner and liquid laundry formulations. These results demonstrate the utility of this patch test method for the comparative skin irritation assessment of these different product types.

  3. Recommendation to include fragrance mix 2 and hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral) in the European baseline patch test series

    DEFF Research Database (Denmark)

    Bruze, Magnus; Andersen, Klaus Ejner; Goossens, An

    2008-01-01

    various European centres when tested in consecutive dermatitis patients. CONCLUSIONS: From 2008, pet. preparations of fragrance mix 2 at 14% w/w (5.6 mg/cm(2)) and hydroxyisohexyl 3-cyclohexene carboxaldehyde at 5% w/w (2.0 mg/cm(2)) are recommended for inclusion in the baseline series. With the Finn...... Chamber technique, a dose of 20 mg pet. preparation is recommended. Whenever there is a positive reaction to fragrance mix 2, additional patch testing with the 6 ingredients, 5 if there are simultaneous positive reactions to hydroxyisohexyl 3-cyclohexene carboxaldehyde and fragrance mix 2, is recommended....

  4. EX1301: Ship Shakedown and Patch Test Exploration, NE Canyons and Seamounts on NOAA Ship Okeanos Explorer between 20130318 and 20130405

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Following annual ship shakedown and patch tests, EX1301 will complete the comprehensive mapping of the Northeast canyons and the adjacent continental shelf carried...

  5. Topical non-peptide antagonists of sensory neurotransmitters substance P and CGRP do not modify patch test and prick test reactions

    DEFF Research Database (Denmark)

    Wallengren, Joanna; Edvinsson, Lars

    2014-01-01

    developed. Their effect on the skin barrier was measured in terms of transepidermal water loss (TEWL) while permeation was calculated using permeation coefficients. Patch tests in patients allergic to nickel and prick test reactions to histamine were used as models. None of the treatments increased TEWL...... vasoconstriction in the skin but did not change the infiltration of nickel reactions. None of the treatments influenced the nickel patch test induced pruritus. The data suggest that the topical application of non-peptide antagonists penetrates the skin but does not inhibit contact dermatitis or pruritus.......Immunologic responses in the skin can be modulated by such neurotransmitters of sensory nerve fibers as substance P (SP) and calcitonin gene-related peptide (CGRP). The first-generation receptor antagonists were peptides with large molecules and had to be injected intracutaneously. The aim...

  6. Thermal Testing of Woven TPS Materials in Extreme Entry Environments

    Science.gov (United States)

    Gonzales, G.; Stackpoole, M.

    2014-01-01

    NASAs future robotic missions to Venus and outer planets, namely, Saturn, Uranus, Neptune, result in extremely high entry conditions that exceed the capabilities of current mid density ablators (PICA or Avcoat). Therefore mission planners assume the use of a fully dense carbon phenolic heatshield similar to what was flown on Pioneer Venus and Galileo. Carbon phenolic (CP) is a robust TPS however its high density and thermal conductivity constrain mission planners to steep entries, high heat fluxes, high pressures and short entry durations, in order for CP to be feasible from a mass perspective. In 2012 the Game Changing Development Program in NASAs Space Technology Mission Directorate funded NASA ARC to investigate the feasibility of a Woven Thermal Protection System to meet the needs of NASAs most challenging entry missions. The high entry conditions pose certification challenges in existing ground based test facilities. Recent updates to NASAs IHF and AEDCs H3 high temperature arcjet test facilities enable higher heatflux (2000 Wcm2) and high pressure (5 atm) testing of TPS. Some recent thermal tests of woven TPS will be discussed in this paper. These upgrades have provided a way to test higher entry conditions of potential outer planet and Venus missions and provided a baseline against carbon phenolic material. The results of these tests have given preliminary insight to sample configuration and physical recession profile characteristics.

  7. Contact allergy to fragrances: current patch test results (2005-2008) from the Information Network of Departments of Dermatology.

    Science.gov (United States)

    Uter, Wolfgang; Geier, Johannes; Frosch, Peter; Schnuch, Axel

    2010-11-01

    Contact sensitization to fragrances is common both in clinical and in population samples. The spectrum of allergens is broad and diverse, and to some extent covered by a set of screening agents. To examine the current frequency of contact sensitization to fragrance allergens in patients routinely patch tested for suspected allergic contact dermatitis with the baseline series and special series. Between 2005 and 2008, 40 709 patients were patch tested in the departments of the Information Network of Departments of Dermatology (http://www.ivdk.org). Results with selected fragrances were analysed. Of all patients tested with the German baseline series, 15.1% reacted positively to fragrance mix (FM) I (6.6% positive), FM II (4.6% positive) or Myroxylon pereirae resin (balsam of Peru, 6.8% positive). Among the single constituents of FM I, Evernia prunastri [oak moss absolute (abs.)] was the leading allergen, and amyl cinnamal the least frequent allergen. Among fragrances not included in FM I or FM II, Evernia furfuracea (tree moss abs.) was the most common allergen. For diagnostic purposes, it is necessary to combine several screening agents. The frequency of contact sensitization differs greatly between single fragrances. © 2010 John Wiley & Sons A/S.

  8. Cyclical and patch-like GDNF distribution along the basal surface of Sertoli cells in mouse and hamster testes.

    Directory of Open Access Journals (Sweden)

    Takeshi Sato

    Full Text Available BACKGROUND AND AIMS: In mammalian spermatogenesis, glial cell line-derived neurotrophic factor (GDNF is one of the major Sertoli cell-derived factors which regulates the maintenance of undifferentiated spermatogonia including spermatogonial stem cells (SSCs through GDNF family receptor α1 (GFRα1. It remains unclear as to when, where and how GDNF molecules are produced and exposed to the GFRα1-positive spermatogonia in vivo. METHODOLOGY AND PRINCIPAL FINDINGS: Here we show the cyclical and patch-like distribution of immunoreactive GDNF-positive signals and their close co-localization with a subpopulation of GFRα1-positive spermatogonia along the basal surface of Sertoli cells in mice and hamsters. Anti-GDNF section immunostaining revealed that GDNF-positive signals are mainly cytoplasmic and observed specifically in the Sertoli cells in a species-specific as well as a seminiferous cycle- and spermatogenic activity-dependent manner. In contrast to the ubiquitous GDNF signals in mouse testes, high levels of its signals were cyclically observed in hamster testes prior to spermiation. Whole-mount anti-GDNF staining of the seminiferous tubules successfully visualized the cyclical and patch-like extracellular distribution of GDNF-positive granular deposits along the basal surface of Sertoli cells in both species. Double-staining of GDNF and GFRα1 demonstrated the close co-localization of GDNF deposits and a subpopulation of GFRα1-positive spermatogonia. In both species, GFRα1-positive cells showed a slender bipolar shape as well as a tendency for increased cell numbers in the GDNF-enriched area, as compared with those in the GDNF-low/negative area of the seminiferous tubules. CONCLUSION/SIGNIFICANCE: Our data provide direct evidence of regionally defined patch-like GDNF-positive signal site in which GFRα1-positive spermatogonia possibly interact with GDNF in the basal compartment of the seminiferous tubules.

  9. Charged Matter Tests of Cosmic Censorship for Extremal and Nearly-Extremal Black Holes

    Science.gov (United States)

    Sorce, Jonathan; Wald, Robert

    2017-01-01

    We investigate scenarios in which adding electrically charged matter to a black hole may cause it to become over-extremal, violating cosmic censorship. It has previously been shown that when the matter is localized as a point particle, no violation occurs for extremal black holes to lowest nonvanishing order in the particle's charge and mass. However, recent work has suggested that violations may be possible when the black hole deviates from extremality. We show that these potential violations always occur above lowest nonvanishing order, and conclude that no lowest-order violation can occur in the nearly-extremal case unless a violation also occurs in the extremal case. We also extend the previous results on point particles to show that no violations occur to second order in charge when an arbitrary charged matter configuration is added to an extremal Kerr black hole, provided only that the matter satisfies the null energy condition.

  10. Skin Irritation to Glass Wool or Continuous Glass Filaments as Observed by a Patch Test among Human Japanese Volunteers

    Science.gov (United States)

    TSUNODA, Masashi; KIDO, Takamasa; MOGI, Sachiyo; SUGIURA, Yumiko; MIYAJIMA, Eriko; KUDO, Yuichiro; KUMAZAWA, Tatenao; AIZAWA, Yoshiharu

    2014-01-01

    Glass wool and continuous glass filaments have been used in industry. We examined the irritability of those among Japanese. A patch test was performed on 43 volunteers for the followings: glass wool for non-residential use with and without a urea-modified phenolic resin binder, that for residential use with and without the binder, and continuous glass filaments with diameters of 4, 7, 9, and 13 µm. Materials were applied to an upper arm of each volunteer for 24 h. The skin was observed at 1 and 24 h after the removal. At 1 h after removal, slight erythema was observed on the skin of a woman after the exposure to glass wool for residential use without the binder. Erythema was observed on the skin of another woman at 1 h after a 24-h exposure to glass wool for non-residential use without the binder. There were no reactions at 24 h after the removal. The low reactions in the patch test suggested that the irritability caused by glass wool, irrespective of a resin component, could be induced mechanically, and that the irritability caused by continuous glass filaments with resin could be slight and either mechanical or chemical. PMID:25070402

  11. Skin irritation to glass wool or continuous glass filaments as observed by a patch test among human Japanese volunteers.

    Science.gov (United States)

    Tsunoda, Masashi; Kido, Takamasa; Mogi, Sachiyo; Sugiura, Yumiko; Miyajima, Eriko; Kudo, Yuichiro; Kumazawa, Tatenao; Aizawa, Yoshiharu

    2014-01-01

    Glass wool and continuous glass filaments have been used in industry. We examined the irritability of those among Japanese. A patch test was performed on 43 volunteers for the followings: glass wool for non-residential use with and without a urea-modified phenolic resin binder, that for residential use with and without the binder, and continuous glass filaments with diameters of 4, 7, 9, and 13 µm. Materials were applied to an upper arm of each volunteer for 24 h. The skin was observed at 1 and 24 h after the removal. At 1 h after removal, slight erythema was observed on the skin of a woman after the exposure to glass wool for residential use without the binder. Erythema was observed on the skin of another woman at 1 h after a 24-h exposure to glass wool for non-residential use without the binder. There were no reactions at 24 h after the removal. The low reactions in the patch test suggested that the irritability caused by glass wool, irrespective of a resin component, could be induced mechanically, and that the irritability caused by continuous glass filaments with resin could be slight and either mechanical or chemical.

  12. In-Situ Micromechanical Testing in Extreme Environments

    Science.gov (United States)

    Lupinacci, Amanda Sofia

    In order to design engineering applications that can withstand extreme environments, we must first understand the underlying deformation mechanisms that can hinder material performance. It is not enough to characterize the mechanical properties alone, we must also characterize the microstructural changes as well so that we can understand the origin of material degradation. This dissertation focuses on two different extreme environments. The first environment is the cryogenic environment, where we focus on the deformation behavior of solder below the ductile to brittle transition temperature (DBTT). The second environment is the irradiated environment, where we focus on the effects that ion beam irradiation has on both the mechanical properties and microstructure of 304 stainless steel. Both classes of materials and testing environments utilize novel in situ micromechanical testing techniques inside a scanning electron microscope which enhances our ability to link the observed deformation behavior with its associated mechanical response. Characterizing plasticity mechanisms below the DBTT is traditionally difficult to accomplish in a systematic fashion. Here, we use a new experimental setup to perform in situ cryogenic mechanical testing of pure Sn micropillars at room temperature and at -142 °C. Subsequent electron microscopy characterization of the micropillars shows a clear difference in the deformation mechanisms at room temperature and at cryogenic temperatures. At room temperature, the Sn micropillars deformed through dislocation plasticity while at -142 °C they exhibited both higher strength and deformation twinning. Two different orientations were tested, a symmetric (100) orientation and a non-symmetric (45¯1) orientation. The deformation mechanisms were found to be the same for both orientations. This approach was also extended to a more complex solder alloy that is commonly used in industry, Sn96. In the case of the solder alloy more complex geometries

  13. Testes de contato e HIV: avaliação comparativa quanto à confiabilidade dos resultados Patch tests and HIV: comparing reliability of results

    Directory of Open Access Journals (Sweden)

    Sabrina de Stefani

    2008-02-01

    Full Text Available FUNDAMENTOS: A ocorrência da dermatite de contato alérgica em pacientes soropositivos para o HIV foi pouco estudada até o momento (apenas relatos de caso. Os testes de contato são considerados o exame complementar padrão para a investigação diagnóstica desse tipo de reação alérgica e não foram avaliados cientificamente nesse grupo de pacientes. OBJETIVO: Avaliar a aplicabilidade dos testes de contato em pacientes soropositivos para o HIV. MÉTODO: Estudo transversal, descritivo, com controles. Um grupo com 16 pacientes soropositivos para o HIV foi comparado a um grupo com 32 pacientes com sorologia desconhecida para o HIV com relação à positividade aos testes. Foi realizada análise estatística bivariada com nível de significância p BACKGROUND: Allergic contact dermatitis in HIV-positive patients has not been thoroughly studied (there are only case reports. Patch tests are the gold standard for diagnosis of this type of allergic reaction and have not been scientifically assessed in such patients. OBJECTIVE: To evaluate the applicability of patch tests in HIV-positive patients. METHODS: A cross-sectional, controlled and descriptive study. A group of 16 HIV-positive patients was compared to a group of 32 patients with unknown HIV sorology results. Bivariate statistical analysis was performed with significance level of p<0.05. RESULTS: Seven patients (43.75% in the HIV-positive group and 18 (56.25% in the unknown sorology group had patch positive tests. CONCLUSIONS: Regardless of immunodeficiency, the findings of this study suggest that specific immunologic memory and the ability to positively respond to tests may remain active. Therefore, this standard and important diagnostic method for allergic contact dermatitis is valid when applied to a group of HIV patients.

  14. Independent test assessment using the extreme value distribution theory.

    Science.gov (United States)

    Almeida, Marcio; Blondell, Lucy; Peralta, Juan M; Kent, Jack W; Jun, Goo; Teslovich, Tanya M; Fuchsberger, Christian; Wood, Andrew R; Manning, Alisa K; Frayling, Timothy M; Cingolani, Pablo E; Sladek, Robert; Dyer, Thomas D; Abecasis, Goncalo; Duggirala, Ravindranath; Blangero, John

    2016-01-01

    The new generation of whole genome sequencing platforms offers great possibilities and challenges for dissecting the genetic basis of complex traits. With a very high number of sequence variants, a naïve multiple hypothesis threshold correction hinders the identification of reliable associations by the overreduction of statistical power. In this report, we examine 2 alternative approaches to improve the statistical power of a whole genome association study to detect reliable genetic associations. The approaches were tested using the Genetic Analysis Workshop 19 (GAW19) whole genome sequencing data. The first tested method estimates the real number of effective independent tests actually being performed in whole genome association project by the use of an extreme value distribution and a set of phenotype simulations. Given the familiar nature of the GAW19 data and the finite number of pedigree founders in the sample, the number of correlations between genotypes is greater than in a set of unrelated samples. Using our procedure, we estimate that the effective number represents only 15 % of the total number of independent tests performed. However, even using this corrected significance threshold, no genome-wide significant association could be detected for systolic and diastolic blood pressure traits. The second approach implements a biological relevance-driven hypothesis tested by exploiting prior computational predictions on the effect of nonsynonymous genetic variants detected in a whole genome sequencing association study. This guided testing approach was able to identify 2 promising single-nucleotide polymorphisms (SNPs), 1 for each trait, targeting biologically relevant genes that could help shed light on the genesis of the human hypertension. The first gene, PFH14, associated with systolic blood pressure, interacts directly with genes involved in calcium-channel formation and the second gene, MAP4, encodes a microtubule-associated protein and had already been

  15. Atopy patch tests in young adult patients with atopic dermatitis and controls: dose-response relationship, objective reading, reproducibility and clinical interpretation

    DEFF Research Database (Denmark)

    Bygum, Anette; Mørtz, Charlotte G; Andersen, Klaus Ejner

    2003-01-01

    The clinical interpretation and reproducibility of atopy patch tests was studied in 23 selected young adult patients with atopic dermatitis and 25 healthy controls using standard inhalant allergens. Non-invasive measurements were used for objective assessment of test reactions and the participants......-dependent results were obtained with Dermatophagoides pteronyssinus, grass and cat with a reproducibility rate of 0.69 to 0.81 in patients and 0.60-0.96 in controls. A unique finding was a significant positive correlation between a positive atopy patch test, allergen dose and increase in transepidermal water loss...... and erythema, while measurement of capacitance did not distinguish between positive and negative reactions. The results of the present study do not support the routine use of atopy patch tests in the evaluation of adult patients with atopic dermatitis....

  16. Quantitative aspects of isoeugenol contact allergy assessed by use and patch tests

    DEFF Research Database (Denmark)

    Johansen, J D; Andersen, Klaus Ejner; Menné, T

    1996-01-01

    in 4/19 (20%) of the test subjects. The ROAT was performed with a test solution of 0.2% isoeugenol in ethanol, which is the recommended maximum concentration used in perfumes, ethanol being applied as vehicle control. 4 weeks was the maximum exposure period. The upper arm was used as test site the 1st...

  17. Contact allergic dermatitis from melamine formaldehyde resins in a patient with a negative patch-test reaction to formaldehyde.

    Science.gov (United States)

    García Gavin, Juan; Loureiro Martinez, Manuel; Fernandez-Redondo, Virginia; Seoane, Maria-José; Toribio, Jaime

    2008-01-01

    Melamine paper is a basic material used in the furniture industry for home and office interiors. Contact allergic dermatitis from melamine formaldehyde resins (MFRs) should be considered in patients who work on melamine paper impregnation lines. We report a case of a 28-year-old female plywood worker who developed eczema on the dorsal side of her hands and wrists after 2 years of working on the melamine paper impregnation line. She had a relevant positive patch-test reaction to MFR, with a negative reaction to formaldehyde. Contact dermatitis due to MFR is not common, and it is usually related to products that are not fully cured or to close contact with intermediate products on the assembly line. Formaldehyde release from MFR can explain most of the positive responses. To our knowledge, this is the first report of MFR contact allergic dermatitis in a worker on a melamine paper impregnation line.

  18. Primary irritation index and safety zone of cosmetics: retrospective analysis of skin patch tests in 7440 Korean women during 12 years.

    Science.gov (United States)

    An, S M; Ham, H; Choi, E J; Shin, M K; An, S S; Kim, H O; Koh, J S

    2014-02-01

    Cosmetics are products used over long periods by the public, and their safety is very important. Several types of human tests are used widely for the evaluation of cosmetics including single patch tests, in-use tests, human repeated insult patch test (HRIPT). However, there is no clear and well-defined published objective and standardized criteria for primary skin irritation in regard to the large variety of cosmetic products. This study analysed human patch tests conducted from May 2001 to December 2012 with 4606 materials of prototype or finished cosmetic products on 7440 normal Korean women aged 18-60 years. The tested products were patched under occlusion for 24 or 48 h, and skin tolerance was assessed twice at 30 min and 24 h after patch removal using a 5-step scale according to the CTFA guidelines. Human patch tests for cosmetics were performed of 4606 cases, and 30-33 subjects participated in each case. The response in each case was calculated based on total subject number, skin reaction intensity and the number of respondents. The calculated response was standardized using the z-score, and a safety zone was provided in terms of human primary irritation in accordance with the human skin reaction evaluation criteria and usage or formula of cosmetics. This study established the safety criteria for irritation in the cosmetics field. © 2013 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

  19. Comparison of simultaneous patch testing with parthenolide and sesquiterpene lactone mix

    DEFF Research Database (Denmark)

    Orion, E; Paulsen, E; Andersen, Klaus Ejner

    1998-01-01

    Several studies have pointed out that the sesquiterpene lactone (SL) mix is a safe, though inadequate, screen for Compositae allergy. To test the usefulness of the sesquiterpene lactone parthenolide as a supplementary Compositae screening test to the mix, both were included in the standard series...

  20. Growing pains : how drug testing keeps workers and assets safe in a booming oil patch

    Energy Technology Data Exchange (ETDEWEB)

    Paulgaard, T.S.

    2006-06-15

    Drug abuse has become a subject of concern to the oil and gas industry, where mistakes in the operation of large machines can result in injury, death and the loss of millions of dollars. Pre-employment urine tests are becoming standard procedure in the oil field. Many supervisors refuse to let employees start work without a clear test. Urine samples are tested for the presence of cannabis, cocaine, opiates, amphetamines and phencyclidine. When a worker is injured or killed on the job, or after an uncommon error that causes significant damage, all parties involved are tested as soon as possible and a receipt of the results are expedited. The Alberta Human Rights and Citizenship Commission is now addressing the issue of drug testing, and has ascertained that drug and alcohol testing are only allowable in certain circumstances, and that it is discriminatory to test potential or existing employees for drug and alcohol use if the testing is not reasonable or justifiable. They have also suggested that there is a duty to accommodate persons with disabilities in the workplace. Drug and alcohol dependency fall within the meaning of disabled. Under the Construction Owner's Association of Alberta's Canadian Model for a Safe Workplace, testing must work in concert with treatment. Current employees are directed to seek help via an employee assistant plan. Workers and supervisors report that drug use is rampant in work camps. Industry-wide, fail rates for those who take part in drug testing are quoted by experts as ranging from between 2 to 14 per cent. 2 figs.

  1. Phototoxicity of bergamot oil assessed by in vitro techniques in combination with human patch tests.

    Science.gov (United States)

    Kejlová, K; Jírová, D; Bendová, H; Kandárová, H; Weidenhoffer, Z; Kolárová, H; Liebsch, M

    2007-10-01

    The aim of this study was to clarify the differences in the phototoxicity of bergamot oil obtained from four different suppliers. Spectral and chemical analyses were performed to identify presence of photoactive compounds in the test samples. The phototoxicity was assessed in vitro by the 3T3 NRU phototoxicity test (PT) and subsequently in a phototoxicity test on reconstructed human skin model (H3D PT). Confirmatory photopatch tests in a group of volunteers were performed using the first non-phototoxic concentration determined in the H3D PT. The spectral and chemical analyses revealed, that two samples of bergamot oil exhibited a potential for photoactivation. These oils were subsequently classified as phototoxic in the 3T3 NRU PT, however, only on the basis of borderline results and depending on the solvent used. H3D PT revealed clear classifications, correlating well with the findings of spectral and chemical analysis. The test was, however, not yet capable of precise prediction of safe, non-phototoxic concentrations. Additional endpoints, e.g. interleukin determination might be employed to increase the sensitivity of the test. Although the study showed the usefulness of the tiered testing strategy, currently, the extrapolation of in vitro results to human situation may be performed only to a limited extent.

  2. Comparison of simultaneous patch testing with parthenolide and sesquiterpene lactone mix

    DEFF Research Database (Denmark)

    Orion, E; Paulsen, E; Andersen, Klaus Ejner

    1998-01-01

    Several studies have pointed out that the sesquiterpene lactone (SL) mix is a safe, though inadequate, screen for Compositae allergy. To test the usefulness of the sesquiterpene lactone parthenolide as a supplementary Compositae screening test to the mix, both were included in the standard series...... in 2 Danish dermatology departments. Among 2244 patients tested, 46 (2%) were positive to SL mix and 73-75% of these were positive to parthenolide. The results demonstrate that parthenolide is not suitable as a supplementary screening agent to SL mix, but may be a fairly good screen on its own...

  3. Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data.

    Science.gov (United States)

    Jírová, Dagmar; Basketter, David; Liebsch, Manfred; Bendová, Hana; Kejlová, Kristina; Marriott, Marie; Kandárová, Helena

    2010-02-01

    Efforts to replace the rabbit skin irritation test have been underway for many years, encouraged by the EU Cosmetics Directive and REACH. Recently various in vitro tests have been developed, evaluated and validated. A key difficulty in confirming the validity of in vitro methods is that animal data are scarce and of limited utility for prediction of human effects, which adversely impacts their acceptance. This study examines whether in vivo or in vitro data most accurately predicted human effects. Using the 4-hr human patch test (HPT) we examined a number of chemicals whose EU classification of skin irritancy is known to be borderline, or where in vitro methods provided conflicting results. Of the 16 chemicals classified as irritants in the rabbit, only five substances were found to be significantly irritating to human skin. Concordance of the rabbit test with the 4-hr HPT was only 56%, whereas concordance of human epidermis models with human data was 76% (EpiDerm) and 70% (EPISKIN). The results confirm observations that rabbits overpredict skin effects in humans. Therefore, when validating in vitro methods, all available information, including human data, should be taken into account before making conclusions about their predictive capacity.

  4. Use of the cytosensor microphysiometer to predict results of a 21-day cumulative irritation patch test in humans.

    Science.gov (United States)

    Landin, Wendell E; Mun, Greg C; Nims, Raymond W; Harbell, John W

    2007-09-01

    The cytosensor microphysiometer (mu phi) was investigated as a rapid, relatively inexpensive test to predict performance of skin cleansing wipes on the human 21-day cumulative irritation patch test (21CIPT). It indirectly measures metabolic rate changes in L929 cells as a function of test article dose, by measuring the acidification rate in a low-buffer medium. The dose producing a 50% reduction in metabolic rate (MRD50), relative to the baseline rate, is used as a measure of toxicity. The acute toxicity of the mu phi assay can be compared to the chronic toxicity of the 21CIPT, which is based largely on the exposure of test agents to the epidermal cells, resulting in damage and penetration of the stratum corneum leading to cell toxicity. Two series of surfactant-based cleansing wipe products were tested via the mu phi assay and 21CIPT. The first series, consisting of 20 products, was used to determine a prediction model. The second series of 38 products consisted of routine product development formulas or marketed products. Comparing the results from both tests, samples with an MRD50 greater than 50 mg/ml provided a 21CIPT score consistent with a product that performs satisfactorily in the market. When the MRD50 was greater than 78 mg/ml, the 21CIPT score was usually zero. The mu phi may be more sensitive than the 21CIPT for ranking minimally irritating materials. The mu phi assay is useful as a screen for predicting the performance of a wet wipes formula on the 21CIPT, and concurrently reduces the use of animals for safety testing in a product development program for cleansing wipes.

  5. Patch test results in children and adolescents. Study from the Santa Casa de Belo Horizonte Dermatology Clinic, Brazil, from 2003 to 2010.

    Science.gov (United States)

    Rodrigues, Dulcilea Ferraz; Goulart, Eugênio Marcos Andrade

    2015-01-01

    Patch testing is an efficient method to identify the allergen responsible for allergic contact dermatitis. To evaluate the results of patch tests in children and adolescents comparing these two age groups' results. Cross-sectional study to assess patch test results of 125 children and adolescents aged 1-19 years, with suspected allergic contact dermatitis, in a dermatology clinic in Brazil. Two Brazilian standardized series were used. Seventy four (59.2%) patients had "at least one positive reaction" to the patch test. Among these positive tests, 77.0% were deemed relevant. The most frequent allergens were nickel (36.8%), thimerosal (18.4%), tosylamide formaldehyde resin (6.8%), neomycin (6.4%), cobalt (4.0%) and fragrance mix I (4.0%). The most frequent positive tests came from adolescents (p=0.0014) and females (p=0.0002). There was no relevant statistical difference concerning contact sensitizations among patients with or without atopic history. However, there were significant differences regarding sensitization to nickel (p=0.029) and thimerosal (p=0.042) between the two age groups under study, while adolescents were the most affected. Nickel and fragrances were the only positive (and relevant) allergens in children. Nickel and tosylamide formaldehyde resin were the most frequent and relevant allergens among adolescents.

  6. Patch test results of hand eczema patients : relation to clinical types

    NARCIS (Netherlands)

    Boonstra, M B; Christoffers, W A; Coenraads, P J; Schuttelaar, M L A

    2015-01-01

    BACKGROUND: Allergic contact dermatitis is a well-known cause of hand eczema, although the influence of contact allergens on different clinical types of hand eczema remains still unclear. OBJECTIVE: To identify most common positive tested allergens among hand eczema patients and to define the relati

  7. Patch test results of hand eczema patients : relation to clinical types

    NARCIS (Netherlands)

    Boonstra, M B; Christoffers, W A; Coenraads, P J; Schuttelaar, M L A

    BACKGROUND: Allergic contact dermatitis is a well-known cause of hand eczema, although the influence of contact allergens on different clinical types of hand eczema remains still unclear. OBJECTIVE: To identify most common positive tested allergens among hand eczema patients and to define the

  8. Multicentre patch testing with compositae mix by the Swedish Contact Dermatitis Research Group.

    Science.gov (United States)

    Isaksson, Marléne; Hansson, Christer; Inerot, Annica; Lidén, Carola; Matura, Mihaly; Stenberg, Berndt; Möller, Halvor; Bruze, Magnus

    2011-05-01

    Sesquiterpene lactone mix detects contact allergy to these compounds present in the plant family Asteraceae. This marker is present in many baseline series. An additional marker is Compositae mix, which is not present in many baseline series. To investigate whether this allergen should be inserted into the Swedish baseline series, six dermatology centres representing the Swedish Contact Dermatitis Research Group included Compositae mix into their baseline series for 1.5 years. Of 2818 patients tested, 31 (1.1%) reacted to Compositae mix and 26 (0.9%) to Sesquiterpene lactone mix. Active sensitization to Compositae mix was noted in two cases. Only 0.4% of Asteraceae contact allergy cases would have been missed if Compositae mix had not been tested, a frequency too low to merit its inclusion in the baseline series. Due to obvious geographical differences in frequency in frequency of simultaneous allergic reactions to Compositae mix and Sesquiterpene lactone mix, the question as to whether specific baseline series (including Compositae mix or not as a "tail" substance) should be used in the different centres must be addressed. Another option could be to remove Sesquiterpene lactone mix from the baseline series and substitute it with Compositae mix.

  9. Patch test dose-response study: polysensitized individuals do not express lower elicitation thresholds than single/double-sensitized individuals.

    Science.gov (United States)

    Carlsen, B C; Fischer, L A; Sosted, H; Vølund, A; Menné, T; Johansen, J D

    2009-01-01

    It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group. To examine and compare elicitation dose-response curves and elicitation thresholds in a polysensitized vs. a single/double-sensitized group for allergens to which the test subjects were already sensitized. Fifty-one patients (13 polysensitized and 38 single/double-sensitized) were patch tested with nickel sulphate, methyldibromo glutaronitrile (MDBGN) and p-phenylenediamine (PPD) in dilution series. The ratio between the doses eliciting a response in 50% of patients in the two groups was used as the measure for relative sensitivity. The dose-response curves of the polysensitized group for MDBGN and PPD were shifted to the right, and for nickel sulphate shifted to the left, compared with the single/double-sensitized group. The relative sensitivity for each of the three allergens and a combined relative sensitivity for all three allergens were not significantly different when comparing the polysensitized and single/double-sensitized groups. No increased sensitivity, in the form of distinct elicitation thresholds, could be demonstrated in polysensitized individuals compared with individuals with one or two contact allergies.

  10. Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±-anatoxin A poisoning

    Directory of Open Access Journals (Sweden)

    Subham Banerjee

    2014-06-01

    Full Text Available The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtained after 6 months showed that the optimized patch formulation was stable with respect to drugs content, pH, diffusion, visual inspection, and other analytical parameters.

  11. The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients

    Energy Technology Data Exchange (ETDEWEB)

    Andersen, K.E.; Hamann, K.

    1984-08-01

    The sensitizing potential of seven industrial antimicrobial agents was evaluated using the guinea-pig maximization test. Preventol O extra (o-phenylphenol) did not produce a sensitization reaction. Preventol ON extra (sodium salt of o-phenylphenol), Preventol GD (dichlorophene) and Proxel XL and HL containing 1,2-benzisothiazolin-3-one were weak sensitizers, while Preventol CMK and Preventol L, both containing chlorocresol, were classified as extreme potential sensitizers. Both the weak and the extreme experimental sensitizers are occasional human sensitizers. The interpretation of the test results is discussed.

  12. The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Hamann, K

    1984-01-01

    containing 1,2-benzisothiazolin-3-one were weak sensitizers, while Preventol CMK and Preventol L, both containing chlorocresol, were classified as extreme potential sensitizers. Both the weak and the extreme experimental sensitizers are occasional human sensitizers. The interpretation of the test results......The sensitizing potential of seven industrial antimicrobial agents was evaluated using the guinea-pig maximization test. Preventol O extra (o-phenylphenol) did not produce a sensitization reaction. Preventol ON extra (sodium salt of o-phenylphenol), Preventol GD (dichlorophene) and Proxel XL and HL...

  13. Dose-response testing with nickel sulphate using the TRUE test in nickel-sensitive individuals. Multiple nickel sulphate patch-test reactions do not cause an 'angry back'

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Lidén, C; Hansen, J

    1993-01-01

    of the different concentrations. Readings were performed blind. The results were analysed by means of polynomial multiple-regression methods and a logistic dose-response model. Half the patients (38/72) had a threshold patch-test concentration for nickel sulphate in the range of 3-0.3 microgram/cm2. The 'angry...

  14. Formaldehyde in cosmetics in patch tested dermatitis patients with and without contact allergy to formaldehyde.

    Science.gov (United States)

    Hauksson, Inese; Pontén, Ann; Isaksson, Marléne; Hamada, Haneen; Engfeldt, Malin; Bruze, Magnus

    2016-03-01

    Formaldehyde is a well-known contact sensitizer. Formaldehyde releasers are widely used preservatives in cosmetics. To survey the release of formaldehyde in cosmetics brought by patients investigated because of suspected allergic contact dermatitis, to compare it with information given by the manufacturers on the packages, and to investigate whether formaldehyde-allergic patients are potentially exposed to more cosmetics releasing formaldehyde than dermatitis patients without contact allergy to formaldehyde. Cosmetics from 10 formaldehyde-allergic and 30 non-allergic patients (controls) matched for age and sex were investigated with the chromotropic acid spot test, which is a semiquantitative method measuring the release of formaldehyde. Formaldehyde was found in 58 of 245 (23.7%) products. Twenty-six of 126 (20.6%) leave-on products released formaldehyde, and 17 of 26 (65.4%) of these were not declared to contain formaldehyde or formaldehyde releasers. Among the rinse-off products, there were 32 of 119 (26.8%) formaldehyde-releasing products, and nine of 32 (28.0%) of these were not labelled as containing formaldehyde or formaldehyde releasers. Five of 10 formaldehyde-allergic patients brought leave-on products with ≥ 40 ppm formaldehyde, as compared with 4 of 30 in the control group (p = 0.029). Cosmetic products used by formaldehyde-allergic patients that are not declared to contain formaldehyde or formaldehyde-releasing preservatives should be analysed. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  15. Alcohol flushing and positive ethanol patch test in patients with coronary spastic angina: possible role of aldehyde dehydrogenase 2 polymorphisms.

    Science.gov (United States)

    Mizuno, Yuji; Morita, Sumio; Harada, Eisaku; Shono, Makoto; Morikawa, Yoshinobu; Murohara, Toyoaki; Yasue, Hirofumi

    2013-01-01

    Coronary spasm plays an important role in the pathogenesis of coronary heart disease (CHD) and angina pectoris caused by coronary spasm or coronary spastic angina (CSA) is prevalent in Japan. However, the precise mechanisms underlying coronary spasm are unclear. Alcohol intolerance is prevalent among East Asians, and we previously reported that coronary spasm could be induced by alcohol intake in CSA patients. We herein examined whether CSA is associated with alcohol intolerance in Japanese subjects. The study subjects consisted of 80 CSA patients (57 men/ 23 women, mean age 62 ± 12) and 52 non-CSA patients (25 men/27 women, mean age 63 ± 10). The ethanol patch test (EPT) and questionnaire which evaluates flushing after ethanol intake, along with an examination of clinical features and laboratory chemistry data for CHD risk factors were done. Gender (male) and smoking were higher (p=0.007, and p=0.019, respectively) and plasma HDL cholesterol level was lower (p=0.035) in the CSA patients than in the non-CSA patients. Multivariable logistic regression analysis including age, EPT, smoking, and plasma HDL cholesterol level as independent variables revealed that positive EPT and smoking were significant predictors of CSA (p=0.011 and p=0.016, respectively). Positive EPT and alcohol flushing following alcohol intake, as well as smoking and plasma levels of HDL cholesterol, were significantly associated with CSA in Japanese patients. Therefore, alcohol ingestion as well as smoking is a significant risk factor for CSA in Japanese.

  16. Allergic contact stomatitis to dodecyl gallate? A review of the relevance of positive patch test results to gallates.

    Science.gov (United States)

    Gamboni, Sarah E; Palmer, Amanda M; Nixon, Rosemary L

    2013-08-01

    Gallic acid esters or gallates are antioxidants used as preservatives in food and cosmetics. Few cases of gallates causing allergic contact dermatitis (ACD) have been reported in the literature. We present a case report of a 42-year-old beauty therapist who presented with a swollen tongue. Patch testing was positive to dodecyl gallate, commonly reported as being present in edible oil and oily foods such as margarine. Our patient avoided foods presumed to contain gallates and at the 6-week review reported a substantial improvement in her tongue symptoms. We reviewed our database and found 16 (7%) definitely or possibly relevant reactions to dodecyl gallate, seven (15%) definitely or possibly relevant reactions to propyl gallate and six (3%) definitely or possibly relevant reactions to octyl gallate. Most reactions were attributed to margarine, moisturising cream and lipstick. These products are often mentioned in the literature as containing gallates; however, ingredient labelling and discussions with manufacturers made it difficult to establish whether they are currently present in foods. Ascertaining relevance for these reactions is not always possible.

  17. Can contact allergy to p-phenylenediamine explain the high rates of terpene hydroperoxide allergy? - An epidemiological study based on consecutive patch test results

    DEFF Research Database (Denmark)

    Bennike, Niels Højsager; Lepoittevin, Jean-Pierre; Johansen, Jeanne D

    2017-01-01

    on proteins in mechanistic studies. OBJECTIVES: To test the hypothesis that patients sensitized to PPD are at increased risk of concomitant reactivity to either of the terpene hydroperoxides, owing to a 'common pathway' of skin protein oxidation. METHODS: A database study of consecutively patch tested eczema...... patients (n = 3843) from 2012 to 2015, tested concomitantly with PPD, Lim-OOHs and Lin-OOHs, was performed. Associations were examined by level of concordance and odds ratios (ORs) adjusted for age, sex, and contact allergy to fragrance mix I and fragrance mix II. RESULTS: Concomitant reactions to PPD were...... increased risk (OR 2.11, 95%CI:0.92-4.80) of a positive patch test reaction to Lin-OOHs. CONCLUSIONS: PPD sensitization cannot explain the high rates of sensitization to Lin-OOHs and/or Lim-OOHs. Contact allergy to oxidized linalool is more strongly associated with fragrance allergy than with PPD allergy....

  18. Chloromethylisothiazolone/methylisothiazolone (CMI/MI) use test with a shampoo on patch-test-positive subjects. Results of a multicentre double-blind crossover trial

    DEFF Research Database (Denmark)

    Frosch, P J; Lahti, A; Hannuksela, M

    1995-01-01

    previously sensitized to CMI/MI can successfully use shampoo preserved with CMI/MI. Since some subjects previously sensitized to CMI/MI, or possibly to IU, may develop clinical reactions, it would still be prudent for the clinician to advise alternative products to patients with sensitivity to a shampoo......A randomized, multicentre, double-blind, 2-period crossover study with 2 shampoos was performed on subjects patch-test-positive to 100 ppm CMI/MI. One shampoo was preserved with 15 ppm a.i. CMI/MI, the other with 0.3% imidazolidinyl urea (IU). 27 subjects from 5 European dermatology clinics...... participated. 1 subject discontinued use after severe adverse reactions to the CMI/MI-preserved shampoo and did not evaluate the other shampoo. Another 2 subjects developed moderate symptoms with the CMI/MI-preserved shampoo and discontinued its use, but tolerated the IU-preserved shampoo for the full 2-week...

  19. Outcome of a second patch test reading of TRUE Tests® on D6/7

    DEFF Research Database (Denmark)

    Torp Madsen, Jakob; Andersen, Klaus Ejner

    2013-01-01

    positive on D6/7 after a doubtful (?+) reaction on D3/4. Neomycin was the most frequent allergen giving delayed positive reactions (57%), followed by budesonide (42%) and hydrocortisone-17-butyrate (31%). Conclusion. A total of 4.4% of positive TRUE Test® reactions would be missed, and 9.1% might be missed...

  20. Patch Test Results in Patients with Allergic Contact Dermatitis in the Western Black Sea Region: A Five-Year Retrospective Study

    Directory of Open Access Journals (Sweden)

    Rafet

    2011-12-01

    Full Text Available Background and Design: In this retrospective study, patch test results of 304 patients with allergic contact dermatitis (ACD, who were tested with the European Standard Series, were evaluated. The aim of the study was to determine the frequency of positive reactions to different sensitizers in patients with ACD and to identify sex and age differences.Material and Method: We evaluated a total of 304 patients (195 (64.1% female and 109 (35.9% male who applied to our clinic between the period of January 2003 and December 2008 and who were tested with patch test with the consideration of ACD. Patch test results were assessed according to the International Contact Dermatitis Research Group at 48 and 72 hours after initial application.Results: Lesions of ACD were found to be most frequent on the hands (65.5%. A total of 95 (31.3% patients had one or more positive patch test reactions. The most common allergens were nickel sulfate (14.8% followed by cobalt chloride (9.2%, potassium dichromate (6.6%, balsam of Peru (3.6%, fragrance mix (3.3%, mercaptobenzothiazole (3% and colophonium (2.3%. Positive reactions to nickel sulfate were more common among women, especially those in younger group. Frequency of contact allergy to lanolin, mercapto mix, epoxy resin, paraben mix and quaternium-15 were relatively low, while no positive reaction was obtained to formaldehyde in any case. In 51.6% of patients with positive reaction, the responsible allergen was detected by testing with the European Standard Series.Conclusion: Although this study shows that sensitization rate to metals and fragrance are still high in our region, as well as in our country, and are more frequent in females than in males, future prospective multicenter studies with large number of patients would point out the adequacy of the European Standard Series in our country. (Turk­derm 2011; 45: 198-202

  1. Patch test results with fragrance markers of the baseline series - analysis of the European Surveillance System on Contact Allergies (ESSCA) network 2009-2012

    DEFF Research Database (Denmark)

    Frosch, Peter J; Duus Johansen, Jeanne; Schuttelaar, Marie-Louise A;

    2015-01-01

    of patients consecutively patch tested between 2009 and 2012 in 12 European countries with fragrance allergens contained in the baseline series were collected by the European Surveillance System on Contact Allergies network and descriptively analysed. Four departments used the TRUE Test(®) system. RESULTS......BACKGROUND: Contact allergy to fragrances is common, and impairs quality of life, particularly in young women. OBJECTIVE: To provide current results on the prevalences of sensitization to fragrance allergens used as markers in the baseline series of most European countries. METHODS: Data......: Contact allergy to fragrances is common throughout Europe, with regional variation probably being explained by patch test technique, and differences in exposure and referral patterns. The current basic markers of fragrance sensitivity in the baseline series should be supplemented with additional fragrance...

  2. Fatigue testing of materials under extremal conditions by acoustic method

    NARCIS (Netherlands)

    Baranov, VM; Bibilashvili, YK; Karasevich, VA; Sarychev, GA

    2004-01-01

    Increasing fuel cycle time requires fatigue testing of the fuel clad materials for nuclear reactors. The standard high-temperature fatigue tests are complicated and tedious. Solving this task is facilitated by the proposed acoustic method, which ensures observation of the material damage dynamics, m

  3. Screening for contact-allergens with patch test in Nanjing city%南京地区斑贴变应原种类的初步筛选

    Institute of Scientific and Technical Information of China (English)

    温志华; 高迎霞; 姚煦

    2016-01-01

    Objective:To screen the contact-allergens with patch test in Nanjing. Methods:Forty domes-tic allergens were prepared according to TRUE Test standard patch testing series( 24) and the criterion provid-ed by the international contact dermatitis research group, and on the base of literature review. Four hundred and forty-three patients of contact dermatitis were enrolled into the study and were tested with TRUE Test patch testing series and domestic patch test to compare the positivity rates between the two tests. Results:The positivity rate of domestic allergens was lower than that of TRUE Test patch testing series (73% & 81.7%), with a significant difference ( P<0.05) . When tested with the same12 allergens, the positivity rate was lower in domestic allergens than in TRUE Test patch testing series. Apart from 24 common-used allergens, another 16 domestic allergens had higher positivity rate ( might be common allergens in Nanjing) Conclusion:Except twenty four domestic allergens mentioned in the TRUE Test standard patch testing series,another sixteen aller-gens can be enrolled in the screening allergen in Nanjing city.%目的::筛选南京地区的斑贴变应原种类。方法:参照曲泰斯及国际接触性皮炎研究组提供的标准,并以前期文献分析数据为依据,制备40种斑贴变应原。纳入443例接触性皮炎(湿疹)患者,先后给予曲泰斯和自制斑试变应原检测,观察两组斑试变应原在患者中阳性率差异,以评估在临床应用的可行性。结果:自制斑试变应原总体阳性率低于曲泰斯(73%&81.7%),二者差异具有统计学意义( P<0.05);相同的斑试变应原相比,12种自制斑贴试剂单个变应原检测阳性率低于曲泰斯;除常规检测的24种斑贴变应原外,另外检测到16种阳性率较高斑贴变应原,也是南京地区常见的接触过敏原。结论:除曲泰斯标准变应原系列提及的24种变应原外,另16种阳性率较高的变应原可同

  4. A clinically relevant contact allergy to methyldibromo glutaronitrile at 1% (0.32 mg/cm) detected by a patch test.

    Science.gov (United States)

    Bruze, Magnus; Gruvberger, Birgitta; Zimerson, Erik

    2006-01-01

    Recently, the preservative methyldibromo glutaronitrile (MDBGN) at 0.5% w/w in petrolatum was included in the European standard patch test series based on the studies on chemical stability and consideration of rates of contact allergy, doubtful and irritant reactions as well as information on clinical relevance represented by results of a repeated open application test (ROAT) and patch test concentrations required to diagnose allergic contact dermatitis from MDBGN in individual cases. In this report, a case with a clinically relevant contact allergy to MDBGN, which on the mandatory reading occasion on D3 only was traced by a patch test with MDBGN at 1.0% (0.32 mg/cm2), is presented. The patient suffered from a chronic hand dermatitis, and when the patient stopped using a liquid soap containing MDBGN, the hand dermatitis substantially improved. A ROAT performed in a blinded and controlled way with applications twice daily on the hands with 2 moisturizers with and without MDBGN resulted in a deterioration of the hand dermatitis on the hand to which the MDBGN-preserved moisturizer had been applied.

  5. Accelerated stability testing of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning

    OpenAIRE

    Subham Banerjee; Pronobesh Chattopadhyay; Animesh Ghosh; Shiv Sankar Bhattacharya; Amit Kundu; Vijay Veer

    2014-01-01

    The current study evaluated the stability potential of a transdermal patch composed of eserine and pralidoxime chloride for prophylaxis against (±)-anatoxin A poisoning. The drug combinations were fabricated in an adhesive matrix system supported by a backing membrane and attached to a temporary release liner. Stability testing of the optimized formulation was established for 6 months under accelerated study conditions as per International Conference on Harmonisation guidelines. Results obtai...

  6. Patch testing with serial dilutions and thin-layer chromatograms of oak moss absolutes containing high and low levels of atranol and chloroatranol.

    Science.gov (United States)

    Mowitz, Martin; Zimerson, Erik; Svedman, Cecilia; Bruze, Magnus

    2013-12-01

    Oak moss absolute (Evernia prunastri extract) contains a large number of substances, among them the potent allergens atranol and chloroatranol. Since 2008, their content in oak moss absolute has been restricted by the International Fragrance Association to a maximum level of 100 ppm each. To compare the elicitation capacities of a traditional (sample A) and a treated (sample B) oak moss absolute containing, in total, 27 000 and 66 ppm of atranol and chloroatranol, respectively, and to investigate reactions to components of oak moss absolute separated by thin-layer chromatography (TLC). Fifteen oak moss-allergic subjects were patch tested with serial dilutions and TLC strips of samples A and B. Fifteen subjects reacted to sample A at concentrations ≤ 2.0%, and 2 subjects reacted to sample B at 2.0% but not to lower concentrations. Among 13 subjects reacting to the TLC strip of sample A, 11 reacted to spots with retardation factor values corresponding to those of atranol and/or chloroatranol, and 11 reacted to other areas on the TLC strip. Only one subject reacted to the TLC strip of sample B. The patch test reactivity of sample B was significantly lower than that of sample A. The TLC patch tests indicate the presence of sensitizers other than atranol and chloroatranol in oak moss absolute. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Patch tests and screening for new allergen in 215 cases with contact dermatitis%215例接触性皮炎斑贴试验结果及新致敏原筛查

    Institute of Scientific and Technical Information of China (English)

    郁辉; 侯占英; 徐浪锋; 陈珩; 刘芳

    2010-01-01

    Patch tests were performed in 215 cases with contact dermatitis and 59 cases with noncontact dermatitis who visited the clinic of Xili Hospital, Shenzhen.Results showed that top four allergen for them were 0.1% Merthiolate, 5% nickel sulfate, 7% aromatic compounds and 1% formaldehyde in sequence.There was significant difference in occurrence of dermatitis at the hands, trunk, extremities,face, and periumbilicus caused by these four kinds of allergen (P <0.01 ), with 0.1% Merthiolate mainly causing dermatitis at the face, hands, trunk and extremities, 5% nickel sulfate causing dermatitis at the periumbilicus, trunk and extremities, 7% aromatic compounds causing dermatitis at the hands, trunk,extremities and face, whereas 1% formaldehyde mainly causing facial dermatitis.Concentration of pentyl acetate and rosin spirit used for patch tests should be 20 % and 25 %, respectively.%对215例门诊接触性皮炎及59例非接触性皮炎患者做斑贴试验.结果列前四位的致敏原分别是0.1%硫柳汞、5%硫酸镍、7%芳香混合物、1%甲醛.这4种致敏原在手部、躯干四肢、面部和脐周的患病率差异有统计学意义(P<0.01),提示0.1%硫柳汞主要引起面部、手部、躯干及四肢皮炎,5%硫酸镍主要引起脐周和躯干及四肢皮炎,7%芳香混合物主要引起手部、躯干及四肢、面部皮炎,1%甲醛主要引起面部皮炎;乙酸戊酯、松香水的斑贴试验浓度分别为20%、25%.

  8. Diclofenac Transdermal Patch

    Science.gov (United States)

    Transdermal diclofenac comes as a patch to apply to the skin. Diclofenac patches are usually applied two times a day, once every ... your regular schedule. Do not apply an extra diclofenac patch to make up for a missed dose.

  9. Testing of Radiation Hardness in the Extreme-Ultraviolet Spectral Region

    Science.gov (United States)

    Arp, U.; Ermanoski, I.; Tarrio, C.; Grantham, S.; Hill, S.; Dhez, P.; Lucatorto, T. B.

    2007-01-01

    Currently we are commissioning a second multilayer-based beamline to study the radiation hardness of multilayers under extreme-ultraviolet (EUV) irradiation in an oxidizing atmosphere. Multilayer lifetime is one of the most important issues for the commercialization of extreme-ultraviolet lithography. The beamline employs a spherical multilayer mirror and a beryllium filter. The mirror demagnifies the source and reflects 13.4 nm radiation as well as visible light. The beryllium filter suppresses the visible light reflected by the mirror and provides also a barrier between the extremely clean storage ring vacuum and the water atmosphere of the test chamber.

  10. The role of preoperative pulmonary function tests in the surgical treatment of extremely severe scoliosis

    OpenAIRE

    Lao, Lifeng; Weng, Xisheng; Qiu, Guixing; Shen, Jianxiong

    2013-01-01

    Background The patients with extremely severe spinal deformity are commonly considered high-risk candidates for surgical treatment because of their underlying lung disease. Currently, little has been reported about the postoperative pulmonary complication events in this population. This retrospective study sought to evaluate preoperative pulmonary function tests in the surgical treatment of extremely severe scoliosis. Methods Preoperative forced vital capacity (FVC), FVC ratio, forced expirat...

  11. Heatshield for Extreme Entry Environment Technology: Results from Acreage and Integrated Seams Arcjet Testing

    Science.gov (United States)

    Venkatapathy, Ethiraj

    2016-01-01

    This invited talk will give a brief overview of the integrated heat-shield system design that requires seams and the extreme environment conditions that HEEET should be demonstrated to be capable of thermal performance without fail. We have tested HEEET across many different facilities and at conditions that are extreme. The presentation will highlight the performance of both the acreage as well as integrated seam at these conditions. The Invite talks are 10 min and hence this presentation will be short.

  12. Oceanographic data collected during the EX1601 Transit and Mission Patch Test on NOAA Ship OKEANOS EXPLORER in the North Pacific Ocean from 2016-01-20 to 2016-02-07 (NCEI Accession 0145341)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Normal underway operations and mapping patch testing. Bathymetric mapping of either the Murray or Molokai Fracture Zones during the transit to Hawaii was planned, as...

  13. Oceanographic data collected during the EX1401 (Ship Shakedown and Patch Test Exploration) expedition on NOAA Ship OKEANOS EXPLORER in the North Atlantic Ocean from 2014-02-06 to 2014-02-09 (NODC Accession 0116846)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — To begin the 2014 NOAA Ship Okeanos Explorer field season, a ship shakedown and multibeam patch test was performed off the coast of Rhode Island over Veatch Canyon....

  14. Quantitative Sensory Testing and Current Perception Threshold Testing in Patients With Chronic Pain Following Lower Extremity Fracture.

    Science.gov (United States)

    Griffioen, Mari A; Greenspan, Joel D; Johantgen, Meg; Von Rueden, Kathryn; O'Toole, Robert V; Dorsey, Susan G; Renn, Cynthia L

    2017-01-01

    Chronic pain is a significant problem for patients with lower extremity injuries. While pain hypersensitivity has been identified in many chronic pain conditions, it is not known whether patients with chronic pain following lower extremity fracture report pain hypersensitivity in the injured leg. To quantify and compare peripheral somatosensory function and sensory nerve activation thresholds in persons with chronic pain following lower extremity fractures with a cohort of persons with no history of lower extremity fractures. This was a cross-sectional study where quantitative sensory testing and current perception threshold testing were conducted on the injured and noninjured legs of cases and both legs of controls. A total of 14 cases and 28 controls participated in the study. Mean time since injury at the time of testing for cases was 22.3 (standard deviation = 12.1) months. The warmth detection threshold ( p = .024) and nerve activation thresholds at 2,000 Hz ( p sensory nerve function at the site of injury in patients with chronic pain following lower extremity fractures using quantitative sensory testing and current perception threshold testing.

  15. Testing cosmic censorship conjecture near extremal black holes with cosmological constants

    CERN Document Server

    Zhang, Yuan

    2013-01-01

    Previously, we have shown that extremal Kerr-Newman black holes can be overcharged or overspun by a test particle, indicating possible violation of the cosmic censorship. In this paper, we consider extremal charged and rotating black holes with cosmological constants. By studying the motion of test particles, we find the following results: An extremal Reissner-Nordstrom anti-de Sitter (RN-AdS) black hole can be overcharged by a test particle but an extremal Reissner-Nordstrom de Sitter (RN-dS) black hole cannot be overcharged. We also show that both Kerr-de-Sitter (Kerr-dS) and Kerr-anti-de-Sitter (Kerr-AdS) black holes can be overspun by a test particle, implying a possible breakdown of the cosmic censorship conjecture. For the Kerr-AdS case, the overspinning requires that the energy of the particle be negative, a reminiscent of the Penrose process. In contrast to the extremal RN and Kerr black holes, in which cases the cosmic censorship is upheld, our results suggest some subtle relations between the cosmol...

  16. Patch testing in allergic contact dermatitis: is it useful to perform the cosmetic series in addition to the European standard series?

    Science.gov (United States)

    Ada, S; Seçkin, D

    2010-10-01

    Cosmetics are the causative agents in 8-15% of patients suspected of having allergic contact dermatitis. Patch testing with standard series identifies 70-80% of the responsible allergens in all contact dermatitis; however, many important cosmetic-related allergens may be missed by using standard series alone. The aim of this study was to determine the value of using cosmetic series in addition to the European standard series in patients with suspected allergic contact dermatitis. In this prospective study, 93 consecutive patients suspected of having allergic contact dermatitis were patch tested with the European standard series, and simultaneously with cosmetic series. Positive allergic reactions were further interpreted as clinically relevant or irrelevant. The clinically relevant reactions were subsequently stratified into three subgroups: (i) reactions only to allergen/allergens in the European standard series; (ii) reactions only to allergen/allergens in cosmetic series; and (iii) reactions both to allergen/allergens in the European standard and cosmetic series. A total of 74 positive reactions were observed in 93 patients. However, only 46 (62.2%) of the total positive reactions were found to be clinically relevant. Of all the clinically relevant positive reactions, 27 (58.7%) were caused by the allergens in the European standard series; 19 (41.3%) were caused by the allergens in cosmetic series. Of the 93 patients tested, 44 (47.3%) had at least one positive allergic reaction, 30 (68.2%) of whom had clinically relevance. Of the 30 patients with clinically relevant positive tests, 16 (53.3%) reacted only to allergens in the European standard series; nine (30%) reacted only to cosmetic series allergens; and five (16.7%) reacted both to the European standard and cosmetic series allergens. Among the 45 cosmetic series allergens tested, 15 (33.3%) gave positive reactions of which 14 (93.3%) of those were found to be clinically relevant. The clinically relevant

  17. Ready-to-use house dust mites atopy patch test (HDM-Diallertest), a new screening tool for detection of house dust mites allergy in children.

    Science.gov (United States)

    Benhamou, P H; Kalach, N; Soulaines, P; Donne, N; Dupont, C

    2009-10-01

    to assess the accuracy and safety of a ready-to-use atopy patch test (HDM-Diallertest, DBV Technologies, Paris) in the diagnosis of sensitization to house-dust mite (HDM) allergens in children with or without atopic dermatitis. prospective analysis of a systematic allergic work-up was carried out in 47 children, age 57.4+42 months (mean + SD, range 7 to 176 mo), presenting with isolated or combined atopic dermatitis (AD, n = 28) or other symptoms without AD (control group, n = 19). Children were routinely tested for specific HDM-IgE [against D. pteronyssinus (DPT) and D. farinae (DF)], and skin testing based on HDM (DPT & DF) skin prick test (SPT) and ready-to-use HDM-ATP (HDM-Diallertest), with a reading at 72 hours. 15 children (31.9%) exhibited specific IgE against both DPT and DF, 16 children (34.04%) exhibited positive SPT against DPT and 17 (36.1%) against DF. HDM-Diallertest was positive in 15 cases (31.9%). Among these, 9 exhibited with an eczematous reaction showed an excellent correlation with both SPT and specific IgE for DPT and DF, respectively 93.3%, 97.77%, 90.47%, and 90.47%. The different diagnostic techniques of HDM sensitization neither differ between groups, nor correlated specifically with the different clinical manifestations. No side effect was observed during and after patch testing, except for a local reaction without diffusion outside the local test area. The 3 diagnostic techniques exhibited a comparable level of accuracy for the diagnosis of HDM allergens sensitization. The excellent concordance of the highest class reactions of HDM-Diallertest with the other diagnostic techniques indicates a potential role as a screening tool for the detection of HDM sensitization in infancy.

  18. Demonstration of an instrumented patch

    Science.gov (United States)

    Martinez, M.; Renaud, G.; Backman, D.; Genest, M.; Delannoy, M.

    2007-04-01

    The primary objective of this study was to demonstrate the effectiveness of various strain measurement techniques at detecting the disbonding of a composite repair patch and then using this information to validate a new capacitance based disbond detection technique. The instrumented repair patch was parametrically designed with the help of Finite Element Analysis (FEA) software to have a stress concentration at its tip. This stress concentration was designed to produce a disbond during fatigue testing, without the need for the introduction of any foreign material to create an artificial disbond condition. The aluminum substrate was grit blasted and the instrumented patch was bonded using FM ®73 adhesive, and was cured following the recommendations of the manufacturer. The geometric characteristics of the patch followed standard repair guidelines for such variables as material selection, taper angles and loading conditions, with the exception of the area designed for premature disbond. All test specimens were inspected using non-destructive testing technique (ultrasound pulse echo) to guarantee that no disbonding had occurred during curing of the specimen. The specimens were placed under fatigue loading to induce a disbond condition between the aluminum substrate and the patch. The specimens were cyclically loaded and strain gauges bonded to strategic locations on the aluminum and composite patch surface to be able to measure changes in surface strains as the disbond progressed. A Digital Image Correlation (DIC) system was also used to measure full field strains over the gauge length of the coupon. The DIC results were compared with the strain gauge data and were used to provide a qualitative measure of the load transfer in the bonded specimen, which clearly demonstrated the change in surface strain that occurred as the composite patch disbonded from the aluminum substrate. Thermoelastic Stress Analysis (TSA) was also used to measure surface strains on the

  19. Visuo-Spatial Processing in Autism--Testing the Predictions of Extreme Male Brain Theory

    Science.gov (United States)

    Falter, Christine M.; Plaisted, Kate C.; Davis, Greg

    2008-01-01

    It has been hypothesised that autism is an extreme version of the male brain, caused by high levels of prenatal testosterone (Baron-Cohen 1999). To test this proposal, associations were assessed between three visuo-spatial tasks and prenatal testosterone, indexed in second-to-fourth digit length ratios (2D:4D). The study included children with…

  20. Extreme Wind Calculation Applying Spectral Correction Method – Test and Validation

    DEFF Research Database (Denmark)

    Rathmann, Ole Steen; Hansen, Brian Ohrbeck; Larsén, Xiaoli Guo

    2016-01-01

    We present a test and validation of extreme wind calculation applying the Spectral Correction (SC) method as implemented in a DTU Wind Condition Software. This method can do with a short-term(~1 year) local measured wind data series in combination with a long-term (10-20 years) reference modelled...

  1. Patching. Restitching business portfolios in dynamic markets.

    Science.gov (United States)

    Eisenhardt, K M; Brown, S L

    1999-01-01

    In turbulent markets, businesses and opportunities are constantly falling out of alignment. New technologies and emerging markets create fresh opportunities. Converging markets produce more. And of course, some markets fade. In this landscape of continuous flux, it's more important to build corporate-level strategic processes that enable dynamic repositioning than it is to build any particular defensible position. That's why smart corporate strategists use patching, a process of mapping and remapping business units to create a shifting mix of highly focused, tightly aligned businesses that can respond to changing market opportunities. Patching is not just another name for reorganizing; patchers have a distinctive mindset. Traditional managers see structure as stable; patching managers believe structure is inherently temporary. Traditional managers set corporate strategy first, but patching managers keep the organization focused on the right set of business opportunities and let strategy emerge from individual businesses. Although the focus of patching is flexibility, the process itself follows a pattern. Patching changes are usually small in scale and made frequently. Patching should be done quickly; the emphasis is on getting the patch about right and fixing problems later. Patches should have a test drive before they're formalized but then be tightly scripted after they've been announced. And patching won't work without the right infrastructure: modular business units, fine-grained and complete unit-level metrics, and companywide compensation parity. The authors illustrate how patching works and point out some common stumbling blocks.

  2. Development and Testing of Mechanism Technology for Space Exploration in Extreme Environments

    Science.gov (United States)

    Tyler, Tony R.; Levanas, Greg; Mojarradi, Mohammad M.; Abel, Phillip B.

    2011-01-01

    The NASA Jet Propulsion Lab (JPL), Glenn Research Center (GRC), Langley Research Center (LaRC), and Aeroflex, Inc. have partnered to develop and test actuator hardware that will survive the stringent environment of the moon, and which can also be leveraged for other challenging space exploration missions. Prototype actuators have been built and tested in a unique low temperature test bed with motor interface temperatures as low as 14 degrees Kelvin. Several years of work have resulted in specialized electro-mechanical hardware to survive extreme space exploration environments, a test program that verifies and finds limitations of the designs at extreme temperatures, and a growing knowledge base that can be leveraged by future space exploration missions.

  3. Extreme Wind Calculation Applying Spectral Correction Method – Test and Validation

    DEFF Research Database (Denmark)

    Hansen, Brian Ohrbeck; Larsén, Xiaoli Guo; Kelly, Mark C.

    This report presents a test and validation of extreme wind calculation applying the Spectral Correction method as implemented in the WAsP Engineering 4 software package. The test and validation is based on four sites located in Denmark, one site located in the Netherlands and one site located in ...... in the USA. Calculations have been carried out using wind data from on-site meteorological masts as well as long-term reference wind data.......This report presents a test and validation of extreme wind calculation applying the Spectral Correction method as implemented in the WAsP Engineering 4 software package. The test and validation is based on four sites located in Denmark, one site located in the Netherlands and one site located...

  4. Testing Vegetation Flammability: The Problem of Extremely Low Ignition Frequency and Overall Flammability Score

    Directory of Open Access Journals (Sweden)

    Zorica Kauf

    2014-01-01

    Full Text Available In the recent decades changes in fire regimes led to higher vulnerability of fire prone ecosystems, with vegetation being the only component influencing fire regime which can be managed in order to reduce probability of extreme fire events. For these management practices to be effective reliable information on the vegetation flammability is being crucial. Epiradiator based testing methods are one of the methods commonly used to investigate vegetation flammability and decrease in ignition frequency is always interpreted as a decrease in flammability. Furthermore, gathered information is often combined into a single flammability score. Here we present results of leaf litter testing which, together with previously conducted research on similar materials, show that material with very low ignition frequency under certain testing conditions can be extremely flammable if testing conditions are slightly changed. Additionally, our results indicate that combining measured information into one single flammability score, even though sometimes useful, is not always meaningful and should be performed with caution.

  5. PREDICTION OF FUNCTIONAL MOVEMENT SCREEN™ PERFORMANCE FROM LOWER EXTREMITY RANGE OF MOTION AND CORE TESTS.

    Science.gov (United States)

    Chimera, Nicole J; Knoeller, Shelby; Cooper, Ron; Kothe, Nicholas; Smith, Craig; Warren, Meghan

    2017-04-01

    There are varied reports in the literature regarding the association of the Functional Movement Screen™ (FMS™) with injury. The FMS™ has been correlated with hamstring range of motion and plank hold times; however, limited research is available on the predictability of lower extremity range of motion (ROM) and core function on FMS™ performance. The purpose of this study was to examine whether active lower extremity ROM measurements and core functional tests predict FMS™ performance. The authors hypothesized that lower extremity ROM and core functional tests would predict FMS™ composite score (CS) and performance on individual FMS™ fundamental movement patterns. Descriptive cohort study. Forty recreationally active participants had active lower extremity ROM measured, performed two core functional tests, the single leg wall sit hold (SLWS) and the repetitive single leg squat (RSLS), and performed the FMS™. Independent t tests were used to assess differences between right and left limb ROM measures and outcomes of core functional tests. Linear and ordinal logistic regressions were used to determine the best predictors of FMS™ CS and fundamental movement patterns, respectively. On the left side, reduced DF and SLWS significantly predicted lower FMS™ CS. On the right side only reduced DF significantly predicted lower FMS™ CS. Ordinal logistic regression models for the fundamental movement patterns demonstrated that reduced DF ROM was significantly associated with lower performance on deep squat. Reduced left knee extension was significantly associated with better performance in left straight leg raise; while reduced right hip flexion was significantly associated with reduced right straight leg raise. Lower SLWS was associated with reduced trunk stability performance. FMS™ movement patterns were affected by lower extremity ROM and core function. Researchers should consider lower FMS™ performance as indicative of underlying issues in ROM and

  6. Extreme Wind Calculation Applying Spectral Correction Method – Test and Validation

    OpenAIRE

    Hansen, Brian Ohrbeck; Larsén, Xiaoli Guo; Kelly, Mark C; Rathmann, Ole Steen; Berg, Jacob; Bechmann, Andreas; Sempreviva, Anna Maria; Ejsing Jørgensen, Hans

    2016-01-01

    This report presents a test and validation of extreme wind calculation applying the Spectral Correction method as implemented in the WAsP Engineering 4 software package. The test and validation is based on four sites located in Denmark, one site located in the Netherlands and one site located in the USA. Calculations have been carried out using wind data from on-site meteorological masts as well as long-term reference wind data.

  7. Explaining Extremity in Evaluation of Group Members: Meta-Analytic Tests of Three Theories.

    Science.gov (United States)

    Bettencourt, B Ann; Manning, Mark; Molix, Lisa; Schlegel, Rebecca; Eidelman, Scott; Biernat, Monica

    2016-02-01

    A meta-analysis that included more than 1,100 effect sizes tested the predictions of three theoretical perspectives that explain evaluative extremity in social judgment: complexity-extremity theory, subjective group dynamics model, and expectancy-violation theory. The work seeks to understand the ways in which group-based information interacts with person-based information to influence extremity in evaluations. Together, these three theories point to the valence of person-based information, group membership of the evaluated targets relative to the evaluator, status of the evaluators' ingroup, norm consistency of the person-based information, and incongruency of person-based information with stereotype-based expectations as moderators. Considerable support, but some limiting conditions, were found for each theoretical perspective. Implications of the results are discussed. © 2015 by the Society for Personality and Social Psychology, Inc.

  8. Metal Patch Antenna

    Science.gov (United States)

    Chamberlain, Neil F. (Inventor); Hodges, Richard E. (Inventor); Zawadzki, Mark S. (Inventor)

    2012-01-01

    Disclosed herein is a patch antenna comprises a planar conductive patch attached to a ground plane by a support member, and a probe connector in electrical communication with the conductive patch arranged to conduct electromagnetic energy to or from the conductive patch, wherein the conductive patch is disposed essentially parallel to the ground plane and is separated from the ground plane by a spacing distance; wherein the support member comprises a plurality of sides disposed about a central axis oriented perpendicular to the conductive patch and the ground plane; wherein the conductive patch is solely supported above the ground plane by the support member; and wherein the support member provides electrical communication between the planer conductive patch and the ground plane.

  9. Sleep Sleeping Patch

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    The Sleep Sleeping Patch is a new kind of external patch based on modern sleep medicine research achievements, which uses the internationally advanced transdermal therapeutic system (TTS). The Sleep Sleeping Patch transmits natural sleep inducers such as peppermint and liquorice extracts and melatonin through the skin to induce sleep. Clinical research proves that the Sleep Sleeping Patch can effectively improve insomnia and the quality of sleep. Highly effective: With the modern TTS therapy,

  10. Clinical Study on Cosmetic Allergens by Skin Patch Test%化妆品过敏原皮肤斑贴试验的临床研究

    Institute of Scientific and Technical Information of China (English)

    朱晓敏; 张晓军; 何韶衡

    2012-01-01

    研究的目的是查找出化妆品中易导致人体化妆品皮炎的原料成分,以减少化妆品皮炎的发生几率.采用临床试验筛选研制出的过敏原60种,然后将其中20种过敏原作为实验组和瑞典化学诊断试剂公司生产的“瑞敏”相同成分20种过敏原作为对照组,为临床疑因接触化妆品而导致的过敏性皮炎患者做斑贴试验.156例患者使用研制的60种过敏原斑贴试验有145例出现阳性反应,总阳性率92.95%;其中有9种过敏原斑贴试验的阳性率超过10%.50例患者用研制的20种过敏原与“瑞敏”20种相同成分过敏原对照斑贴试验,结果完全一致的37例,占74%.206例患者均没有出现不良反应.本试验的60种化妆品筛选过敏原用于临床斑贴试验安全、有效.%The purpose of the study is by examining potential allergens in cosmetics, to reduce incidence of dermatitis. Skin patch test was performed for the patients with cosmetic dermatitis by using clinically selected 60 candidate allergens. Among them, 20 allergens were compared with the same allergens from Chemotechnique Diagnostics, Sweden. 145 of 156 patients treated with the above 60 candidate allergens showed positive skin reactions, which counts for 92.95% of total patients examined. For 9 of 60 allergens, the rate of positive results exceeded 10%. Furthermore, skin patch test to 50 patients was performed with our own 20 allergens and with the same allergens purchased from Chemotechnique diagnostics, Sweden. The results showed that 37 of 50 patients (counting for 74% ) have similar positive skin reaction to the same allergens from two different sources. None of the 206 patients had skin adverse reaction. The selected 60 different cosmetic candidate allergens for patch test are safe and effective for clinical use.

  11. Nursing care of patients with cosmetic dermatitis receiving patch test%化妆品接触性皮炎患者斑贴试验的护理

    Institute of Scientific and Technical Information of China (English)

    陈海燕; 郭素萍; 郑跃; 杨素莲; 区风仙

    2013-01-01

    Objective To summarize key points of nursing patients with cosmetic dermatitis during patch test.Method One hundred and forty one patients with contact dermatitis induced by cosmetics underwent patch test and the nursing care was performed. Results The top five allergens based on the positive rate ranked in descending order were potassium dichromate(43�97%),nickel sulfate (43�26%),cobalt chloride(36�17%),mixture of hydroxy benzoic acid(23�40%)and fragrance mix(20�57%).The positive suspicious cosmetics ranked in ascending order included body spray(80�00%),freckle cream(56�00%),liquid products(38�89%),cleaning supplies (31�58%)and skin care cream(25�62%).Conclusion During the cosmetic patch test for the patients with contact dermatitis,the nurses should conduct mental care,carefully observe the patients and make instructions to them on cosmetic health knowledge.%目的探讨化妆品接触性皮炎斑贴试验的护理要点。方法对141例化妆品接触性皮炎患者实施斑贴试验,并配合做好护理工作。结果前5位27种常见的过敏原阳性率从高至低依次为重铬酸钾(43�97%)、硫酸镍(43�26%)、氯化钴(36�17%)、对羟基苯甲酸类混合物(23�40%)、香料混合物(20�57%);可疑化妆品斑贴试验阳性率从高至低依次为香体喷雾(80�00%)、祛斑霜(56�00%)、水剂产品(38�89%)、清洁用品(31�58%)、护肤面霜(25�62%)。结论在化妆品接触性皮炎患者斑贴试验过程中,护士应做好患者斑贴试验前心理工作,试验中接触性皮炎的观察及试验后健康知识指导工作。

  12. Birth Control Patch

    Science.gov (United States)

    ... Surgery? A Week of Healthy Breakfasts Shyness Birth Control Patch KidsHealth > For Teens > Birth Control Patch Print A A A What's in this ... Does It Cost? What Is It? The birth control patch is a thin, beige, 1¾-inch (4½- ...

  13. Birth Control Patch

    Science.gov (United States)

    ... Loss Surgery? A Week of Healthy Breakfasts Shyness Birth Control Patch KidsHealth > For Teens > Birth Control Patch A A A What's in this article? ... Much Does It Cost? What Is It? The birth control patch is a thin, beige, 1¾-inch (4½- ...

  14. Challenges and Opportunities of Centrifugal Microfluidics for Extreme Point-of-Care Testing

    Directory of Open Access Journals (Sweden)

    Issac J. Michael

    2016-02-01

    Full Text Available The advantages offered by centrifugal microfluidic systems have encouraged its rapid adaptation in the fields of in vitro diagnostics, clinical chemistry, immunoassays, and nucleic acid tests. Centrifugal microfluidic devices are currently used in both clinical and point-of-care settings. Recent studies have shown that this new diagnostic platform could be potentially used in extreme point-of-care settings like remote villages in the Indian subcontinent and in Africa. Several technological inventions have decentralized diagnostics in developing countries; however, very few microfluidic technologies have been successful in meeting the demand. By identifying the finest difference between the point-of-care testing and extreme point-of-care infrastructure, this review captures the evolving diagnostic needs of developing countries paired with infrastructural challenges with technological hurdles to healthcare delivery in extreme point-of-care settings. In particular, the requirements for making centrifugal diagnostic devices viable in developing countries are discussed based on a detailed analysis of the demands in different clinical settings including the distinctive needs of extreme point-of-care settings.

  15. Temporary Thermocouple Attachment for Thermal/Vacuum Testing at Non-Extreme Temperatures - Test Results

    Science.gov (United States)

    Wright, Sarah E.; Ungar, Eugene K.

    2017-01-01

    Post-test examination and data analysis that followed a two week long vacuum test showed that numerous self-stick thermocouples became detached from the test article. The thermocouples were reattached with thermally conductive epoxy and the test was repeated to obtain the required data. Because the thermocouple detachment resulted in significant expense and rework, it was decided to investigate the temporary attachment methods used around NASA and to perform a test to assess their efficacy. The present work describes the testing that was performed in early and mid-2017. The test article and the temporary thermocouple attachment methods tested are described. During the first test, fully half of the thermocouples detached - although the detachment showed subtly in the data for some. The second test was performed to confirm the data from the first test and to investigate the effect of test article and thermocouple grounding. The results of the testing over temperatures ranging from -150 to 200degF are detailed and preliminary recommendations are made for temporary thermocouple attachment methods.

  16. Avaliação do teste de contato com aeroalérgenos em pacientes com dermatite atópica Evaluation of patch test with airbone allergic agents in patients with atopic dermatitis

    Directory of Open Access Journals (Sweden)

    Rosana Neves Dos Santos Rodrigues

    2011-02-01

    Full Text Available FUNDAMENTOS: a dermatite atópica é uma doença inflamatória cutânea que apresenta múltiplos fatores desencadeantes. Há vários relatos de autores que confirmaram os aeroalérgenos como fatores agravantes ou desencadeantes. O teste de contato com aeroalérgenos ou teste de contato atópico foi proposto para avaliar a participação destes alérgenos na dermatite atópica. OBJETIVO: objetivo deste estudo foi avaliar a positividade do teste de contato atópico em pacientes com dermatite atópica. MÉTODOS: Avaliamos 50 pacientes com dermatite atópica e 45 do grupo com rinite alérgica, nos quais realizamos teste de contato atópico com extratos de Dermatophagoides pteronissynus, Dermatophagoides farinae e Blomia tropicalis, além de testes cutâneos de leitura imediata para os mesmos alérgenos, acrescidos de epitélio de cão e gato e fungos. RESULTADOS: verificamos que o teste de contato atópico com ácaros apresentou maior positividade nos indivíduos do grupo de dermatite atópica quando comparado ao grupo de rinite alérgica. CONCLUSÕES: o teste de contato atópico apresenta resultados estatisticamente significativos quando realizado com ácaros, em pacientes com dermatite atópica, com p=0,035, OR (odds ratio = 3,35 e IC(95% = [ 1,18; 9,47].BACKGROUND: Atopic dermatitis is an inflammatory skin disease that can be triggered by many factors. Several reports confirm the role of airborne allergic agents as aggravating or triggering factors. The patch test with airborne allergic agents or the atopy patch test was suggested to evaluate the role of these allergens in atopic dermatitis. OBJECTIVE: This study aimed at evaluating the positivity of the atopy patch test in patients with atopic dermatitis. METHODS: We evaluated 50 patients with atopic dermatitis and 45 with allergic rhinitis, the atopy patch test was performed in these patiennts with extracts of Dermatophagoides pteronissynus, Dermatophagoides farinae and Blomia tropicalis, as

  17. The diagnostic accuracy of the atopy patch test in diagnosing hypersensitivity to cow's milk and hen's egg in unselected children with and without atopic dermatitis

    DEFF Research Database (Denmark)

    Osterballe, Morten; Andersen, Klaus E; Bindslev-Jensen, Carsten

    2004-01-01

    BACKGROUND: Previous studies have suggested that the atopy patch test (APT) may make oral challenge superfluous in diagnosing children with food hypersensitivity. OBJECTIVE: To investigate the clinical relevance of APT in predicting hypersensitivity to cow's milk and hen's egg in 486 unselected...... children 3 years of age. METHOD: The children were examined by APT, skin prick (SPT), histamine release (HR), and specific IgE followed by oral challenge when hypersensitivity to cow's milk or hen's egg was suspected. RESULTS: Food hypersensitivity confirmed by oral challenge was 1.6% to hen's egg and 0.......6% to cow's milk. No hypersensitivity to cow's milk or hen's egg was predicted by APT alone. CONCLUSION: APT could not predict food hypersensitivity not predicted by SPT, HR, or specific IgE. Thus, APT cannot be recommended in daily practice for the diagnosis of hypersensitivity to cow's milk and hen's egg...

  18. Positive patch- and photopatch-test reactions to methylene bis-benzotriazolyl tetramethylbutylphenol in patients with both atopic dermatitis and chronic actinic dermatitis.

    Science.gov (United States)

    Gonzalez, Mercedes E; Soter, Nicholas A; Cohen, David E

    2011-01-01

    Ultraviolet filters are the most common topical photoallergens. Although currently not available on the US market, methylene bis-benzotriazolyl tetramethylbutylphenol (referred to as bisoctrizole on product labels) represents a new class of UV filters that have both organic and inorganic properties and are widely available in different preparations in Europe, South America, and Asia. We report two patients with atopic dermatitis and chronic actinic dermatitis who had positive patch- and photopatch-test reactions, which suggested both an allergic contact and a photoallergic contact dermatitis from bisoctrizole. Neither patient could identify previous or current contact with the chemical; nonetheless, it is possible that either the allergic contact or photoallergic contact dermatitis from bisoctrizole led to their chronic actinic dermatitis.

  19. A A field test for extremity dose assessment during outages at Korean nuclear power plants.

    Science.gov (United States)

    Kim, Hee Geun; Kong, Tae Young

    2013-05-01

    During maintenance on the water chamber of a steam generator, the pressuriser heater and the pressure tube feeder in nuclear power plants, workers are likely to receive high radiation doses due to the severe workplace conditions. In particular, it is expected that workers' hands would receive the highest radiation doses because of their contact with the radioactive materials. In this study, field tests for extremity dose assessments in radiation workers undertaking contact tasks with high radiation doses were conducted during outages at pressurised water reactors and pressurised heavy water reactors in Korea. In the test, the radiation workers were required to wear additional thermoluminescent dosemeters (TLDs) on their backs and wrists and an extremity dosemeter on the finger, as well as a main TLD on the chest while performing the maintenance tasks.

  20. Detection of occupational contact dermatitis allergen by using patch test%斑贴试验检测职业性接触陸皮炎变应原

    Institute of Scientific and Technical Information of China (English)

    曾碧冰; 陈明春; 李俊杰; 周敏慧; 李丹; 林绍华; 张静

    2011-01-01

    目的 探讨东莞地区职业性接触性皮炎主要致病因素,了解其常见的接触性变应原.方法 采用斑贴试验试剂盒对每例患者进行斑贴试验.结果 300例患者中有167例至少对一种物质过敏,总阳性率为55.67%,阳性率较高的几种变应原依次为:硫酸镍104例(34.67%),甲醛42例(14.00%),重铬酸钾30例(10.00%).结论 东莞地区职业性接触性皮炎主要变应原为三种化学物质,调查结果有助于临床指导该疾病的预防和治疗.%Aim To analysis the pathogens of occupational contact dermatitis in Dongguan city,and find out the common contact allergens.Methods Patch tests were performed by using RuiminTM serial allergen kit in the patients with occupational contact dermatitis.Results 300 cases of occupational contact dermatitis were patch tested, 167 cases showed positive reaction to one or more allergens, and the positive rate was 55.67%.The most familiar allergens were:nikel sulfate(104 cases,34.67%),formaldehyde(42 cases,14.00%),potassium dichromate(30 cases, 10.00%).Conclusions The main allergens of occupational contact dermatitis in Dongguan city are three kinds of chemical materials.This study is helpful to the prevention and treatment of the disease.

  1. Results of patch testing with fragrance mix 1, fragrance mix 2, and their ingredients, and Myroxylon pereirae and colophonium, over a 21-year period.

    Science.gov (United States)

    Nardelli, Andrea; Carbonez, An; Drieghe, Jacques; Goossens, An

    2013-05-01

    The frequency of fragrance contact allergy has shown a fluctuating trend over the years. To describe the frequency of positive reactions to the baseline screening agents and fragrance mix (FM) 1 and 2 components, to determine trends of the latter over the years, and to evaluate simultaneous reactions. This was a cross-sectional study on patch test results of 13 332 patients from January 1990 to December 2011. Of the total population, 9.6% reacted positively to FM 1, and 6% of 3416 tested with FM 2 reacted positively. Of those tested with both, 30.4% of 349 FM 1-positive patients reacted to FM 2, and 51.7% of 205 FM 2-positive patients reacted to FM 1. Hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) and FM 2 were tested simultaneously in 3401 patients: 6 reacted to HICC alone. Nine hundred and forty patients were tested with FM 1 ingredients and 205 with FM 2 ingredients; Evernia prunastri was the most frequent FM 1 allergen, and HICC was the most frequent FM 2 allergen. Simultaneous reactions were frequently observed. Fragrance-allergic subjects often show multiple positive reactions, some of which are highly significantly associated. Recently, there has been a decreasing trend in positivity for both Evernia prunastri and HICC, whereas a slight increase for cinnamyl alcohol has been observed. © 2013 John Wiley & Sons A/S.

  2. 20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies

    DEFF Research Database (Denmark)

    Carlsen, Berit Christina; Menné, Torkil; Johansen, Jeanne Duus

    2007-01-01

    (Me)isothiazolinone, and primin and poor for paraben mix. 5.1% were multiple allergic, primarily women, and 90% got diagnosed by the first test. Frequency of multiple allergies increased with age. More multiple- than mono/double-allergic patients were tested multiple times. Persistency and sensitivity rates in a Danish eczema...

  3. Sesquiterpene lactone mix patch testing supplemented with dandelion extract in patients with allergic contact dermatitis, atopic dermatitis and non-allergic chronic inflammatory skin diseases.

    Science.gov (United States)

    Jovanović, M; Poljacki, M; Mimica-Dukić, N; Boza, P; Vujanović, Lj; Duran, V; Stojanović, S

    2004-09-01

    We investigated the value of patch testing with dandelion (Compositae) extract in addition to sesquiterpene lactone (SL) mix in selected patients. After we detected a case of contact erythema multiforme after patch testing with dandelion and common chickweed (Caryophyllaceae), additional testing with common chickweed extract was performed. A total of 235 adults with a mean age of 52.3 years were tested. There were 66 men and 169 women: 53 consecutive patients with allergic contact dermatitis (ACD); 43 with atopic dermatitis (AD); 90 non-atopics suffering from non-allergic chronic inflammatory skin diseases; 49 healthy volunteers. All were tested with SL mix 0.1% petrolatum (pet.) and diethyl ether extracts from Taraxacum officinale (dandelion) 0.1 and 3.0% pet. and from Stellaria media (common chickweed) 0.1 and 3% pet. A total of 14 individuals (5.9%) showed allergic reaction (AR) to at least 1 of the plant allergens, 4 (28.6%) to common chickweed extract, and 11 (78.6%) to Compositae allergens. These 11 persons made the overall prevalence of 4.7%: 8 (3.4%) were SL-positive and 3 (1.3%) reacted to dandelion extract. 5 persons (45.5%) had AD, 2 had ACD, 2 had psoriasis and 2 were healthy controls. The Compositae allergy was relevant in 8 cases (72.7%). The highest frequency of SL mix sensitivity (9.3%) was among those with AD. Half the SL mix-sensitive individuals had AD. ARs to dandelion extract were obtained only among patients with eczema. A total of 9 irritant reactions (IRs) in 9 individuals (3.8%) were recorded, 8 to SL mix and 1 to common chickweed extract 3.0% pet. No IR was recorded to dandelion extract (P = 0.007). Among those with relevant Compositae allergy, 50.0% had AR to fragrance mix and balsam of Peru (Myroxylon pereirae resin) and colophonium. SLs were detected in dandelion but not in common chickweed. Our study confirmed the importance of 1 positive reaction for emerging, not fully established, Compositae allergy. In conclusion, the overall

  4. Comparative Performance of Four Single Extreme Outlier Discordancy Tests from Monte Carlo Simulations

    Directory of Open Access Journals (Sweden)

    Surendra P. Verma

    2014-01-01

    Full Text Available Using highly precise and accurate Monte Carlo simulations of 20,000,000 replications and 102 independent simulation experiments with extremely low simulation errors and total uncertainties, we evaluated the performance of four single outlier discordancy tests (Grubbs test N2, Dixon test N8, skewness test N14, and kurtosis test N15 for normal samples of sizes 5 to 20. Statistical contaminations of a single observation resulting from parameters called δ from ±0.1 up to ±20 for modeling the slippage of central tendency or ε from ±1.1 up to ±200 for slippage of dispersion, as well as no contamination (δ=0 and ε=±1, were simulated. Because of the use of precise and accurate random and normally distributed simulated data, very large replications, and a large number of independent experiments, this paper presents a novel approach for precise and accurate estimations of power functions of four popular discordancy tests and, therefore, should not be considered as a simple simulation exercise unrelated to probability and statistics. From both criteria of the Power of Test proposed by Hayes and Kinsella and the Test Performance Criterion of Barnett and Lewis, Dixon test N8 performs less well than the other three tests. The overall performance of these four tests could be summarized as N2≅N15>N14>N8.

  5. 瑞敏系列和TURE TEST系列斑贴试剂检测结果比较%Comparison of Patch Test Results Useing IQ Chamber System and TURE TEST

    Institute of Scientific and Technical Information of China (English)

    曹晓佳; 张理涛

    2012-01-01

    目的 分析瑞敏系列(R)和TURE TEST系列(T)斑贴试剂检测结果及一致性.方法 分别用这两个系列斑贴试剂检测196例慢性湿疹和接触性皮炎患者,对其检测结果进行比较.结果 瑞敏系列和TURE TEST系列斑贴试剂对各变应原检测阳性率不完全相同,它们检测常见变应原种类均与国内已有报道类似;两个系列中相同的16种变应原的检测反应强度一致性较好,检测的阳性率差异无统计学意义(P>0.05).结论 两个系列斑贴试剂的一致性较好,临床上可根据患者情况选择应用.%Objective To study the patch test reactions and the concordance of IQ chamber system (R) and TRUE Test (T). Methods Two different series patch test reagents were performed to detect 196 patients with chronic eczema and contact dermatitis, then the results were compared. Results The positive rates of every allergen were not completely the same,the most common allergens known from two series reagents were similar with the past reported of inland. The strength of allergic reaction of the same 16 allergens of two series reagents had good consistence and the positive rates of R and T were statistically insignificance. Conclusion This two different patch test series exhibited a high level of consistence, and doctors could choose suitable series according to the conditions of patients in clinic.

  6. A goodness-of-fit test for bivariate extreme-value copulas

    CERN Document Server

    Genest, Christian; Nešlehová, Johanna; Yan, Jun; 10.3150/10-BEJ279

    2011-01-01

    It is often reasonable to assume that the dependence structure of a bivariate continuous distribution belongs to the class of extreme-value copulas. The latter are characterized by their Pickands dependence function. In this paper, a procedure is proposed for testing whether this function belongs to a given parametric family. The test is based on a Cram\\'{e}r--von Mises statistic measuring the distance between an estimate of the parametric Pickands dependence function and either one of two nonparametric estimators thereof studied by Genest and Segers [Ann. Statist. 37 (2009) 2990--3022]. As the limiting distribution of the test statistic depends on unknown parameters, it must be estimated via a parametric bootstrap procedure, the validity of which is established. Monte Carlo simulations are used to assess the power of the test and an extension to dependence structures that are left-tail decreasing in both variables is considered.

  7. Patch testing with a new fragrance mix - reactivity to the individual constituents and chemical detection in relevant cosmetic products

    DEFF Research Database (Denmark)

    Frosch, Peter J; Rastogi, Suresh C; Pirker, Claudia

    2005-01-01

    A new fragrance mix (FM II), with 6 frequently used chemicals not present in the currently used fragrance mix (FM I), was evaluated in 6 dermatological centres in Europe, as previously reported. In this publication, test results with the individual constituents and after repeated open application...

  8. Male Youth Perceptions of Violent Extremism: towards a Test of Rational Choice Theory.

    Science.gov (United States)

    Dhami, Mandeep K; Murray, Jennifer

    2016-09-20

    Understanding how people perceive the pros and cons of risky behaviors such as terrorism or violent extremism represents a first step in developing research testing rational choice theory aiming to explain and predict peoples' intentions to engage in, or support, these behaviors. Accordingly, the present study provides a qualitative, exploratory analysis of a sample of 57 male youths' perceptions of the benefits and drawbacks of: (a) accessing a violent extremist website, (b) joining a violent extremist group, and (c) leaving such a group. Youth perceived significantly more drawbacks than benefits of joining a violent extremist group (p = .001, d = .46) and accessing a violent extremist website (p = .001, d = .46). The perceived benefits of engagement referred to gaining knowledge/awareness, being part of a group/similar people, and fighting the enemy/for a cause. The drawbacks referred to being exposed to negative material and emotions, having violent/criminal beliefs and behaviors, and getting in trouble with the law. The perceived benefits of disengagement referred to no longer committing illegal acts, and regaining independence/not being manipulated. The drawbacks referred to exposing oneself to harm and reprisal. These findings provide an insight into how male youth think about (dis)engagement in violent extremism, and can inform future quantitative research designed to explain and predict (dis)engagement in violent extremism. Eventually, such research may inform the development of evidence-based prevention and intervention strategies.

  9. Development of compact extreme ultraviolet interferometry for on-line test of lithography cameras

    Energy Technology Data Exchange (ETDEWEB)

    Ray-Chaudhuri, A.K.; Nissen, R.P.; Krenz, K.D.; Stulen, R.H. [Sandia National Labs., Livermore, CA (United States); Sweatt, W.C.; Warren, M.E.; Wendt, J.R.; Kravitz, S.H. [Sandia National Labs., Albuquerque, NM (United States); Bjorkholm, J.E. [AT and T Bell Labs., Holmdel, NJ (United States)

    1998-12-31

    Extreme ultraviolet lithography (EUVL) is a candidate technology for the microelectronics industry with design rules for 0.1 {micro}m features and beyond. When characterizing an extreme ultraviolet (EUV) lithographic optical system, visible light interferometry is limited to measuring wavefront aberration caused by surface figure error while failing to measure wavefront errors induced by the multilayer coatings. This fact has generated interest in developing interferometry at an EUV camera`s operational wavelength (at-wavelength testing), which is typically around 13 nm. While a laser plasma source (LPS) is being developed as a lithography production source, it has generally been considered that only an undulator located at a synchrotron facility can provide the necessary laser-like point source for EUV interferometry. Although an undulator-based approach has been successfully demonstrated, it would be advantageous to test a camera in its operational configuration. The authors are developing the latter approach by utilizing extended source size schemes to provide usable flux throughput. A slit or a grating mounted in front of the source can provide the necessary spatial coherence for Ronchi interferometry. The usable source size is limited only by the well-corrected field of view of the camera under test. The development of this interferometer will be presented.

  10. Extreme Ground-Motion Rockfall Deposits on the Nevada Test Site

    Science.gov (United States)

    Whitney, J. W.; Buckingham, S. E.; Magner, J. E.; Finkel, R. C.; Brune, J. N.; von Seggern, D.; Honke, J. S.

    2007-12-01

    In order to detect the evidence of extreme ground motion in the past, we have begun to catalog geomorphic characteristics that distinguish slope deposits strongly influenced by extreme ground motion from deposits primarily influenced by climate processes. Underground nuclear explosions (UNEs) of yields between 200 kilotons and 1.3 megatons were conducted under Pahute Mesa at the Nevada Test site from 1962 to 1992. The primary surface effects from these tests were surface cracks, triggered earthquakes, offsets on pre-existing faults, and changes in land surface topography. Rockfall and rock spall were observed along cliffs after a few nuclear tests; however, few observations of accumulations of shattered rock were documented. A large volume of rockfall located along a 1.5-km¬-long cliff of welded ash-flow tuff resulted from extreme ground motions from two nearby UNEs. In 1968 UNE Rickey released maximum ground motions of 500 cm/s peak ground velocity (PGV) at the closest cliff face and PGV decreased to about 300 cm/s at the north end of the cliff. Large boulders with 1-3-m average diameters were shaken loose from fracture planes and cooling joints to form a stack of jumbled boulders at the base of the cliff. Very few large boulders rolled to the base of the hillslope. Subsequently, in 1976, UNE Pool induced 300-350 cm/s PGV along the same cliff. A significant volume of rock, also released along fractures and joints, was added to the coarse boulder colluvium shaken loose in 1968. Ground motion from Pool also rearranged the hillslope boulders from UNE Rickey, but did not cause many boulders to roll downslope. Extreme ground motions from these two UNEs resulted in 1.5-3.0 m of physical erosion to the cliff face. Rockfall from less welded ash-flow tuff units situated above and below the cliff produced significantly less boulder colluvium. Our observations indicate that boulder size and rockfall volume from a cliff or ridge crest due to extreme ground motion are

  11. 669例湿疹皮炎患者斑贴试验分析%Patch test of eczema and dermatitis:An analysis of 669 cases

    Institute of Scientific and Technical Information of China (English)

    邹先彪; 张文英; 王东红; 杨宇光; 刘少卿; 李蕾; 仇萌

    2011-01-01

    Objective To study the contact allergens in patients with chronic eczema and dermatitis and their characteristics. Methods Patch test was performed to detect contact allergens in 669 patients with chronic eczema and dermatitis. Results Of the 669 patients with chronic eczema and dermatitis, 312 were positive for patch test. Of these 312 patients, 164,78,44, 19 and 7 were positive for 1, 2, 3,4 and over 5 allergens, respectively. The positive rate to nickel sulfate was the highest(17.19%), followed by cobalt chloride, potassium dichromate, aromatic mixture, colophane, parabens, formaldehyde and paraphenylenediamine. Conclusion Nickel sulfate, cobalt chloride, potassium dichromate, and aromatic mixture are the important contact allergens for eczema and dermatitis in our area.%目的 探讨慢性湿疹和皮炎患者接触性致敏原及其特点。方法 采用斑贴试验检查669例皮炎湿疹患者。结果 669例皮炎湿疹患者中斑贴试验阳性312例,其中对1种物质过敏164例,2种物质过敏78例,3种物质过敏44例,4种物质过敏19例,5种及以上物质过敏7例。其中以硫酸镍最高为17.19%,其余依次是氯化钴、重铬酸钾、芳香混合物、松香、对苯类、甲醛及对苯二胺。结论 硫酸镍、氯化钴、重铬酸钾和芳香化合物是本地区湿疹皮炎患者重要的致敏原。

  12. Upper extremity neurodynamic tests: range of motion asymmetry may not indicate impairment.

    Science.gov (United States)

    Covill, Laura G; Petersen, Shannon M

    2012-10-01

    Upper extremity (UE) neurodynamic tests are used to examine neural tissue in patients with neuro-musculoskeletal disorders. Although comparisons between involved and uninvolved limbs are made clinically, minimal data exist reflecting the normal variation between sides. The purpose of this study was to determine if within-subject differences exist between limbs in the UE component of neurodynamic tests of the median, radial, and ulnar nerves. Sixty-one healthy subjects were examined. Difference between limbs for the median nerve-biased test was significant (right=16.4° ± 11.4°, left=20.1° ± 13.7°; p=0.045). There was no significant difference between limbs for the radial or ulnar nerve-biased tests. Correlation between limbs was poor for all tests (median r(2) =0.14; radial r(2) =0.20; ulnar r(2) =0.13). Lower-bound scores were calculated to determine the amount of difference needed to consider asymmetry beyond measurement error; the scores for each neurodynamic test were as follows: median 27°, radial 20°, and ulnar 21°. The results of this study show that between-limb values have low correlation and that it may be normal for an individual to have range of motion differences between limbs with neurodynamic tests.

  13. Content Range and Precision of a Computer Adaptive Test of Upper Extremity Function for Children with Cerebral Palsy

    Science.gov (United States)

    Montpetit, Kathleen; Haley, Stephen; Bilodeau, Nathalie; Ni, Pengsheng; Tian, Feng; Gorton, George, III; Mulcahey, M. J.

    2011-01-01

    This article reports on the content range and measurement precision of an upper extremity (UE) computer adaptive testing (CAT) platform of physical function in children with cerebral palsy. Upper extremity items representing skills of all abilities were administered to 305 parents. These responses were compared with two traditional standardized…

  14. Content Range and Precision of a Computer Adaptive Test of Upper Extremity Function for Children with Cerebral Palsy

    Science.gov (United States)

    Montpetit, Kathleen; Haley, Stephen; Bilodeau, Nathalie; Ni, Pengsheng; Tian, Feng; Gorton, George, III; Mulcahey, M. J.

    2011-01-01

    This article reports on the content range and measurement precision of an upper extremity (UE) computer adaptive testing (CAT) platform of physical function in children with cerebral palsy. Upper extremity items representing skills of all abilities were administered to 305 parents. These responses were compared with two traditional standardized…

  15. Granisetron Transdermal Patch

    Science.gov (United States)

    ... are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using transdermal granisetron, call your doctor.plan to protect the granisetron patch and the skin around it from real and artificial sunlight (tanning beds, sunlamps). Keep the patch covered ...

  16. Unit Testing Using Design by Contract and Equivalence Partitions, Extreme Programming and Agile Processes in Software Engineering

    DEFF Research Database (Denmark)

    Madsen, Per

    2003-01-01

    Extreme Programming [1] and in particular the idea of Unit Testing can improve the quality of the testing process. But still programmers need to do a lot of tiresome manual work writing test cases. If the programmers could get some automatic tool support enforcing the quality of test cases then t...... then the overall quality of the software would improve significantly....

  17. Unit Testing Using Design by Contract and Equivalence Partitions, Extreme Programming and Agile Processes in Software Engineering

    DEFF Research Database (Denmark)

    Madsen, Per

    2003-01-01

    Extreme Programming [1] and in particular the idea of Unit Testing can improve the quality of the testing process. But still programmers need to do a lot of tiresome manual work writing test cases. If the programmers could get some automatic tool support enforcing the quality of test cases...

  18. Design and preliminary test of precision segment positioning actuator for the California Extremely Large Telescope

    Science.gov (United States)

    Lorell, Kenneth R.; Aubrun, Jean-Noel; Clappier, Robert R.; Shelef, Ben; Shelef, Gad

    2003-01-01

    In order for the California Extremely Large Telescope (CELT) to achieve the required optical performance, each of its 1000 primary mirror segments must be positioned relative to adjacent segments with nanometer-level accuracy. This can be accomplished using three actuators for each segment to actively control the segment in tip, tilt, and piston. The Keck telescopes utilize a segmented primary mirror similar to CELT employing a highly successful actuator design. However, because of its size and the shear number of actuators (3000 vs. 108 for Keck), CELT will require a different design. Sensitivity to wind loads and structural vibrations, the large dynamic range, low operating power, and extremely reliable operation, all achieved at an affordable unit cost, are the most demanding design requirements. This paper examines four actuator concepts and presents a trade-off between them. The concept that best met the CELT requirements is described along with an analysis of its performance. The concept is based on techniques that achieve the required accuracy while providing a substantial amount of vibration attenuation and damping. A prototype actuator has been built to validate this concept. Preliminary tests confirm predicted behavior and future tests will establish a sound baseline for final design and production.

  19. Testing for scale-invariance in extreme events, with application to earthquake occurrence

    Science.gov (United States)

    Main, I.; Naylor, M.; Greenhough, J.; Touati, S.; Bell, A.; McCloskey, J.

    2009-04-01

    We address the generic problem of testing for scale-invariance in extreme events, i.e. are the biggest events in a population simply a scaled model of those of smaller size, or are they in some way different? Are large earthquakes for example ‘characteristic', do they ‘know' how big they will be before the event nucleates, or is the size of the event determined only in the avalanche-like process of rupture? In either case what are the implications for estimates of time-dependent seismic hazard? One way of testing for departures from scale invariance is to examine the frequency-size statistics, commonly used as a bench mark in a number of applications in Earth and Environmental sciences. Using frequency data however introduces a number of problems in data analysis. The inevitably small number of data points for extreme events and more generally the non-Gaussian statistical properties strongly affect the validity of prior assumptions about the nature of uncertainties in the data. The simple use of traditional least squares (still common in the literature) introduces an inherent bias to the best fit result. We show first that the sampled frequency in finite real and synthetic data sets (the latter based on the Epidemic-Type Aftershock Sequence model) converge to a central limit only very slowly due to temporal correlations in the data. A specific correction for temporal correlations enables an estimate of convergence properties to be mapped non-linearly on to a Gaussian one. Uncertainties closely follow a Poisson distribution of errors across the whole range of seismic moment for typical catalogue sizes. In this sense the confidence limits are scale-invariant. A systematic sample bias effect due to counting whole numbers in a finite catalogue makes a ‘characteristic'-looking type extreme event distribution a likely outcome of an underlying scale-invariant probability distribution. This highlights the tendency of ‘eyeball' fits unconsciously (but wrongly in

  20. Frequent occurrence of T cell–mediated late reactions revealed by atopy patch testing with hypoallergenic rBet v 1 fragments

    Science.gov (United States)

    Campana, Raffaela; Moritz, Katharina; Marth, Katharina; Neubauer, Angela; Huber, Hans; Henning, Rainer; Blatt, Katharina; Hoermann, Gregor; Brodie, Tess M.; Kaider, Alexandra; Valent, Peter; Sallusto, Federica; Wöhrl, Stefan; Valenta, Rudolf

    2015-01-01

    Background Late allergic reactions are common in the course of allergen-specific immunotherapy and even occur with allergy vaccines with reduced IgE reactivity. Objective We sought to study atopy patch test (APT) reactions and T-cell responses to the recombinant birch pollen allergen Bet v 1 and recombinant hypoallergenic T-cell epitope–containing Bet v 1 fragments in patients with birch pollen allergy with and without atopic dermatitis (AD). Methods A clinical study was conducted in 15 patients with birch pollen allergy with AD (group 1), 5 patients with birch pollen allergy without AD (group 2), 5 allergic patients without birch pollen allergy (group 3), and 5 nonallergic subjects (group 4) by performing skin prick tests and APTs with rBet v 1 and hypoallergenic rBet v 1 fragments. T-cell, cutaneous lymphocyte antigen (CLA)+ and CCR4+ T-cell and cytokine responses were studied by thymidine uptake, carboxyfluorescein diacetate succinimidyl ester staining, and Luminex technology, respectively. Results rBet v 1 and hypoallergenic rBet v 1 fragments induced APT reactions in not only most of the patients with birch pollen allergy with AD (11/15) but also in most of those without AD (4/5). Patients with birch pollen allergy with AD had higher Bet v 1–specific proliferation of CLA+ and CCR4+ T cells compared with patients with birch pollen allergy without AD. There were no differences in Bet v 1–specific CLA+ and CCR4+ proliferation and cytokine secretion in patients with and without APT reactions. Conclusion Hypoallergenic rBet v 1 fragments induce T cell–dependent late reactions not only in patients with birch pollen allergy with AD but also in those without AD, which can be determined based on APT results but not based on in vitro parameters. PMID:26518092

  1. Test-retest and inter- and intrareliability of the quality of the upper-extremity skills test in preschool-age children with cerebral palsy

    NARCIS (Netherlands)

    Haga, Nienke; van der Heijden-Maessen, Helene C.; van Hoorn, Jessika F.; Boonstra, Antje; Hadders-Algra, Mijna

    2007-01-01

    Objective: To investigate the test-retest, inter-, and intraobserver reliability of the Quality of Upper Extremity Skills Test (QUEST) in young children with cerebral palsy (CP). Design: For test-retest reliability, a test-retest design was used; for the intra- and interobserver reliability, the

  2. Extremely low vertical-emittance beam in accelerator-test facility at KEK

    Energy Technology Data Exchange (ETDEWEB)

    Kubo, K.; Akemoto, M.; Anderson, S.; Aoki, T.; Araki, S.; Bane, K.L.F.; Blum, P.; Corlett, J.; Dobashi, K.; Emma, P.; Frisch, J.; Fukuda, M.; Guo, Z.; Hasegawa, K.; Hayano, H.; Higo, T.; Higurashi, A.; Honda, Y.; Iimura, T.; Imai, T.; Jobe, K.; Kamada, S.; Karataev, P.; Kashiwagi, S.; Kim, E.; Kobuki, T.; Kotseroglou, T.; Kurihara, Y.; Kuriki, M.; Kuroda, R.; Kuroda, S.; Lee, T.; Luo, X.; McCormick, D.J.; McKee, B.; Mimashi, T.; Minty, M.; Muto, T.; Naito, Takashi; Naumenko, G.; Nelson, J.; Nguyen, M.N.; Oide, K.; Okugi, T.; Omori, T.; Oshima, T.; Pei, G.; Potylitsyn, A.; Qin, Q.; Raubenheimer, T.; Ross, M.; Sakai, H.; Sakai, I.; Schmidt, F.; Slaton, T.; Smith, H.; Smith, S.; Suzuki, Toshikazu; Takano, M.; Takeda, Seishi; Terunuma, N.; Toge, N.; Turner, J.; Urakawa, J.; Vogel, V.; Woodley, M.; Yocky, J.; Young, A.; Zimmerman, F.; ATF Collaboration

    2002-05-13

    Electron beams with the lowest, normalized transverse emittance recorded so far were produced and confirmed in single-bunch-mode operation of the Accelerator Test Facility at KEK. We established a tuning method of the damping rings which achieves a small vertical dispersion and small x-y orbit coupling. The vertical emittance was less than 1 percent of the horizontal emittance. At the zero-intensity limit, the vertical normalized emittance was less than 2.8 x 10{sup -8} rad m at beam energy 1.3 GeV. At high intensity, strong effects of intrabeam scattering were observed, which had been expected in view of the extremely high particle density due to the small transverse emittance.

  3. The GenePOC Platform, a Rational Solution for Extreme Point-of-Care Testing

    Directory of Open Access Journals (Sweden)

    Luc Bissonnette

    2016-05-01

    Full Text Available Extreme point-of-care (POC testing for infections, as performed (endured in low-resource settings, developing countries, tropical areas, or in conditions following emergency crises or natural disasters, must be undertaken under environmental, logistic, and societal conditions which impose a significant deal of stress on local human populations and healthcare providers. For disease diagnostics or management, simple and robust biomedical equipment and reagents are required and needed. This chapter aims to overview some of these stresses (requirements and intends to describe some of the solutions already engineered at the heart of centripetal (centrifugal microfluidic platforms such as that of GenePOC Inc. to enable rapid, robust, and reproducible nucleic acid-based diagnostics of infectious diseases, to better control the morbidity and mortality of infections and the expanding threat posed by antimicrobial resistance.

  4. Selecting Video Key Frames Based on Relative Entropy and the Extreme Studentized Deviate Test

    Directory of Open Access Journals (Sweden)

    Yuejun Guo

    2016-03-01

    Full Text Available This paper studies the relative entropy and its square root as distance measures of neighboring video frames for video key frame extraction. We develop a novel approach handling both common and wavelet video sequences, in which the extreme Studentized deviate test is exploited to identify shot boundaries for segmenting a video sequence into shots. Then, video shots can be divided into different sub-shots, according to whether the video content change is large or not, and key frames are extracted from sub-shots. The proposed technique is general, effective and efficient to deal with video sequences of any kind. Our new approach can offer optional additional multiscale summarizations of video data, achieving a balance between having more details and maintaining less redundancy. Extensive experimental results show that the new scheme obtains very encouraging results in video key frame extraction, in terms of both objective evaluation metrics and subjective visual perception.

  5. Windows Security patch required

    CERN Multimedia

    2003-01-01

    This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables, ... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  6. Windows Security patch required

    CERN Multimedia

    2003-01-01

    This concerns Windows PCs which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables, ... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  7. Windows Security patch required

    CERN Multimedia

    3004-01-01

    This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables,... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  8. Windows Security patch required

    CERN Multimedia

    2003-01-01

    This concerns Windows PCs (XP, 2000, NT) which are NOT centrally managed at CERN for security patches, e.g. home PCs, experiment PCs, portables,... A security hole which can give full privileges on Windows systems needs to be URGENTLY patched. Details of the security hole and hotfix are at: http://cern.ch/it-div/news/hotfix-MS03-026.asp http://www.microsoft.com/technet/security/bulletin/MS03-026.asp

  9. Extremely Low-Stress Triaxiality Tests in Calibration of Fracture Models in Metal-Cutting Simulation

    Science.gov (United States)

    Šebek, František; Kubík, Petr; Petruška, Jindřich; Hůlka, Jiří

    2016-11-01

    The cutting process is now combined with machining, milling, or drilling as one of the widespread manufacturing operations. It is used across various fields of engineering. From an economical point of view, it is desirable to maintain the process in the most effective way in terms of the fracture surface quality or minimizing the burr. It is not possible to manage this experimentally in mass production. Therefore, it is convenient to use numerical computation. To include the crack initiation and propagation in the computations, it is necessary to implement a suitable ductile fracture criterion. Uncoupled ductile fracture models need to be calibrated first from fracture tests when the test selection is crucial. In the present article, there were selected widespread uncoupled ductile fracture models calibrated with, among others, an extremely low-stress triaxiality test realized through the compression of a cylinder with a specific recess. The whole experimental program together with the cutting process experiment were carried out on AISI 1045 carbon steel. After the fracture models were calibrated and the cutting process was simulated with their use, fracture surfaces and force responses from computations were compared with those experimentally obtained and concluding remarks were made.

  10. G-patch domain containing 2, a gene highly expressed in testes, inhibits nuclear factor-κB and cell proliferation.

    Science.gov (United States)

    Hu, Fen; Gou, Lixia; Liu, Qing; Zhang, Wendian; Luo, Mengmeng; Zhang, Xiujun

    2015-02-01

    G-patch domain containing 2 (GPATC2), a human gene that is highly expressed in the testes, was implicated as a novel cancer/testis antigen. The present study investigated GPATC2 expression in a number of human cell lines and rat tissues, and its potential biological function in 293T cells. Semi‑quantitative reverse transcription-polymerase chain reaction analysis showed that GPATC2 was widely expressed in 15 human cell lines (representing different lineages) and in 11 different rat tissues, and that the GPATC2 mRNA relative expression level was significantly higher in the testis than it was in other tissues. 293T cells were transiently transfected with GPATC2-p enhanced green fluorescent protein (EGFP)‑N1 or GPATC2-pEGFP-C3 and the nuclei were stained with 4',6'‑diamidino‑2‑phenylindole. The results showed that GPATC2 is predominantly expressed in the nucleus of 293T cells. Overexpression of GPATC2 may inhibit transcription of the NF-κB reporter gene. The role of GPATC2 in proliferation was analyzed with cell counting kit-8, colony-forming efficiency and flow cytometry assays. The results indicated that over‑expression of GPATC2 in 293T cells significantly inhibited cell proliferation by decreasing the number of cells in S phase. By contrast, GPATC2 knockdown by RNA interference exhibited the opposite effect, suggesting that GPATC2 may be involved in inhibiting G1-S phase transition in 293T cells. In conclusion, these results provide novel insight into the breadth of expression of GPATC2 and its role in cell proliferation.

  11. 皮炎湿疹类皮肤病斑贴试验结果分析%Analysis of patch-test results of para eczema and dermatitis

    Institute of Scientific and Technical Information of China (English)

    张艳杰; 尚艳华; 王凯

    2010-01-01

    目的 探讨皮炎湿疹类皮肤病接触性致敏原及其特点,以期更好地诊断与治疗.方法 对340例皮炎湿疹类皮肤病患者采用标准筛选抗原进行斑贴试验.结果 340例患者中275例对20种标准筛选抗原中的18种出现1种或1种以上抗原阳性反应,总阳性反应率为80.88%,其中以硫酸镍阳性率最高,达29.70%,其余阳性率较高者依次为重铬酸钾(27.64%)、芳香混合物(22.35%)、卡巴混合物(20.29%)、硫柳汞(18.82%.)、苯唑卡因(17.94%).结论 硫酸镍、重铬酸钾、芳香混合物、卡巴混合物是目前引起皮炎湿疹类患者的主要变应原,斑贴试验有助于明确皮炎湿疹类变态反应性皮肤病及接触性致敏原及其性质.%Objective To investigate the characteristics of contact allergens in eczema and dermatitis for further diagnosis and treatment. Methods 340 cases with eczema and dermatitis were tested with a standardized screening antigen kit. Results (80. 88% ) of the 340 patients tested had at least one positive allergen among 18 of 20 standardized screening antigen. The first six allergens were nickel sulfate ( 29. 70% ), potassium dichroroate (27.64% ) ,fragrant mix(22.35% ) ,carba mix(20.29% ) ,thimerosal( 18. 82% ) ,benzocaine( 17.94% ). Conclusion Nickel sulfate,potassium dichromate,fragrance mix and carba mix were the main allergens causing dermatitis and eczema presently. Patch-testing was helpful in identifying the property of contact allergens in para eczema and dermatitis.

  12. Patch testing with methylchloroisothiazolinone/methylisothiazolinone 200 ppm aq. detects significantly more contact allergy than 100 ppm. A multicentre study within the European Environmental and Contact Dermatitis Research Group

    DEFF Research Database (Denmark)

    Bruze, Magnus; Isaksson, Marléne; Andersen, Klaus Ejner;

    2014-01-01

    BACKGROUND: Methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are the active ingredients in commonly used preservative systems (e.g. Kathon CG(®) ). MCI/MI is present in the European baseline patch test series at 100 ppm aq. Since 1986, 200 ppm (dose 0.006 mg/cm(2) ) has been used...... in 3300 consecutively tested dermatitis patients at eight European patch test clinics and one US patch test clinic. With the Finn Chambers(®) technique (diameter 8 mm), 15 µl was micropipetted on to the filter paper in the chamber. The corresponding volume for Van der Bend(®) chambers was 20 µl......, and that for IQ Chambers(®) was 25 µl. RESULTS: Contact allergy to MCI/MI at 100 and 200 ppm was found in 1.2% and 2.1% of patients, respectively (p contact allergy than the presently used concentration of 100 ppm (dose...

  13. Patch-augmented rotator cuff repair: influence of the patch fixation technique on primary biomechanical stability.

    Science.gov (United States)

    Jung, Christian; Spreiter, Gregor; Audigé, Laurent; Ferguson, Stephen J; Flury, Matthias

    2016-05-01

    There is an ongoing debate about the potential of patch augmentation to improve biomechanical stability and healing associated with rotator cuff repair. The biomechanical properties of three different patch-augmented rotator cuff repair techniques were assessed in vitro and compared with a standard repair. Dermal collagen patch augmentation may increase the primary stability and strength of the repaired tendon in vitro, depending on the technique used for patch application. Forty cadaveric sheep shoulders with dissected infraspinatus tendons were randomized into four groups (n = 10/group) for tendon repair using a knotless double-row suture anchor technique. A xenologous dermal extracellular matrix patch was used for augmentation in the three test groups using an "integrated", "cover", or "hybrid" technique. Tendons were preconditioned, cyclically loaded from 10 to 30 N at 1 Hz, and then loaded monotonically to failure. Biomechanical properties and the mode of failure were evaluated. Patch augmentation significantly increased the maximum load at failure by 61 % in the "cover" technique test group (225.8 N) and 51 % in the "hybrid" technique test group (211.4 N) compared with the non-augmented control group (140.2 N) (P ≤ 0.015). For the test group with "integrated" patch augmentation, the load at failure was 28 % lower (101.6 N) compared with the control group (P = 0.043). There was no significant difference in initial and linear stiffness among the four experimental groups. The most common mode of failure was tendon pullout. No anchor dislocation, patch disruption or knot breakage was observed. Additional patch augmentation with a collagen patch influences the biomechanical properties of a rotator cuff repair in a cadaveric sheep model. Primary repair stability can be significantly improved depending on the augmentation technique.

  14. Physical properties of gum karaya-starch-essential oil patches.

    Science.gov (United States)

    Shcherbina, Yulia; Roth, Zvi; Nussinovitch, Amos

    2010-09-01

    Essential oils are used in foods, cosmetics, and pharmaceuticals. Despite the recent marketing of novel essential-oil-containing patches, there is no information on their production, constituents, or physical properties. The objectives of this study were to produce essential-oil patches and characterize their physical properties. The essential oil of Lavandula angustifolia (lavender) was included at concentrations of 2.5% to 10% in patches manufactured from the exudate gum karaya, propylene glycol, glycerol, emulsifier, and optionally, potato starch as filler. Inclusion of essential oil reduced patch strength, stiffness, and elasticity relative to patches without essential oil. Inclusion of starch in the essential-oil patches strengthened them, but reduced their elasticity. Patches' adhesion to substrate was examined by both peeling and probe-tack tests: the higher the inclusion of essential oils within the patch, the larger the decrease in its adhesion to substrate. Addition of starch to essential-oil-containing patches increased their adhesion relative to their essential-oil-only counterparts. Scanning electron micrographs of the patches provided evidence of entrapped starch granules. Although inclusion of essential oil reduced both the mechanical properties and adhesion of the patches, a high proportion of essential oil can still be included without losing patch integrity or eliminating its adhesiveness to the skin.

  15. Topical ketoprofen patch.

    Science.gov (United States)

    Mazières, Bernard

    2005-01-01

    Although oral nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the treatment of a variety of acute and chronic pain conditions, their use may be associated with serious systemic adverse effects, particularly gastrointestinal disorders. In order to minimise the incidence of systemic events related to such agents, topical NSAIDs have been developed. Topical NSAIDs, applied as gels, creams or sprays, penetrate the skin, subcutaneous fatty tissue and muscle in amounts that are sufficient to exert a therapeutic effect on peripheral and central mechanisms in the absence of high plasma concentrations. Data indicate that topical NSAIDs are effective at relieving pain in a number of acute and chronic pain indications. This review article discusses the pharmacokinetics, efficacy and tolerability of a new formulation of ketoprofen available as a topical patch. The topical patch containing ketoprofen 100mg as the active principle has been developed using a novel delivery system that dispenses therapeutic doses of the drug directly to the site of injury. Pharmacokinetic data indicate that although plasma levels of ketoprofen are higher when the drug is administered as a patch versus a gel, the total systemic bioavailability of ketoprofen 100 mg administered via a patch is no more than 10% of that reported for ketoprofen 100 mg administered orally. Because the patch facilitates ketoprofen delivery over a 24-hour period, the drug remains continually present in the tissue subjacent to the site of application. High tissue but low plasma ketoprofen concentrations mean that while tissue concentrations are high enough to exert a therapeutic effect, plasma concentrations remain low enough to not result in systemic adverse events caused by elevated serum NSAID levels. Phase III clinical trials in patients with non-articular rheumatism and traumatic painful soft tissue injuries showed that the topical ketoprofen patch was significantly more effective than placebo at

  16. Esophageal Inlet Patch

    Directory of Open Access Journals (Sweden)

    C. Behrens

    2011-01-01

    Full Text Available An inlet patch is a congenital anomaly consisting of ectopic gastric mucosa at or just distal to the upper esophageal sphincter. Most inlet patches are largely asymptomatic, but in problematic cases complications related to acid secretion such as esophagitis, ulcer, web and stricture may occur. The diagnosis of inlet patch is strongly suggested on barium swallow where the most common pattern consists of two small indentations on the wall of the esophagus. The diagnosis of inlet patch is confirmed via endoscopy with biopsy. At endoscopy, the lesion appears salmon-coloured and velvety and is easily distinguished from the normal grey-white squamous epithelium of the esophagus. The prominent margins correlate with the radiological findings of indentations and rim-like shadows on barium swallow. Histopathology provides the definitive diagnosis by demonstrating gastric mucosa adjacent to normal esophageal mucosa. No treatment is required for asymptomatic inlet patches. Symptomatic cases are treated with proton pump inhibitors to relieve symptoms related to acid secretion. Strictures and webs are treated with serial dilatation and should be biopsied to rule out malignancy.

  17. Testing the AGB Scenario as the Origin of the Extreme-Helium Population in omega Centauri

    CERN Document Server

    Choi, Ena

    2008-01-01

    The most massive Galactic globular cluster, Omega centauri, appears to have multiple populations. Its bluest main sequence and extended horizontal branch stars are suggested to have the common origin, that is, an extremely high helium abundance of Y ~ 0.4. The high helium abundance is most often attributed to asymptotic giant branch (AGB) stars. In this study we test the AGB hypothesis. We simulate the maximum-AGB models where the impact of AGB stars is maximised by assuming that supernova explosions do not affect the chemical evolution of the proto cloud. We compare the enrichment history of helium, metals, carbon and nitrogen to the observed values. Even under the most generous condition, the maximum-AGB models fail to reproduce the large values of helium Y ~ 0.4 and helium enrichment parameter Delta Y / Delta Z ~ 70 which were deduced from the colour-magnitude diagram fits. They also fail to reproduce the C and N contents of the blue population spectroscopically determined. We conclude that the AGB scenari...

  18. Wafer and reticle positioning system for the Extreme Ultraviolet Lithography Engineering Test Stand

    Energy Technology Data Exchange (ETDEWEB)

    WRONOSKY,JOHN B.; SMITH,TONY G.; CRAIG,MARCUS J.; STURGIS,BEVERLY R.; DARNOLD,JOEL R.; WERLING,DAVID K.; KINCY,MARK A.; TICHENOR,DANIEL A.; WILLIAMS,MARK E.; BISCHOFF,PAUL

    2000-01-27

    This paper is an overview of the wafer and reticle positioning system of the Extreme Ultraviolet Lithography (EUVL) Engineering Test Stand (ETS). EUVL represents one of the most promising technologies for supporting the integrated circuit (IC) industry's lithography needs for critical features below 100nm. EUVL research and development includes development of capabilities for demonstrating key EUV technologies. The ETS is under development at the EUV Virtual National Laboratory, to demonstrate EUV full-field imaging and provide data that supports production-tool development. The stages and their associated metrology operated in a vacuum environment and must meet stringent outgassing specifications. A tight tolerance is placed on the stage tracking performance to minimize image distortion and provide high position repeatability. The wafer must track the reticle with less than {+-}3nm of position error and jitter must not exceed 10nm rms. To meet these performance requirements, magnetically levitated positioning stages utilizing a system of sophisticated control electronics will be used. System modeling and experimentation have contributed to the development of the positioning system and results indicate that desired ETS performance is achievable.

  19. Generic patch inference

    DEFF Research Database (Denmark)

    Andersen, Jesper; Lawall, Julia

    2010-01-01

    A key issue in maintaining Linux device drivers is the need to keep them up to date with respect to evolutions in Linux internal libraries. Currently, there is little tool support for performing and documenting such changes. In this paper we present a tool, spdiff, that identifies common changes...... developers can use it to extract an abstract representation of the set of changes that others have made. Our experiments on recent changes in Linux show that the inferred generic patches are more concise than the corresponding patches found in commits to the Linux source tree while being safe with respect...

  20. Patch testing with 2.0% (0.60 mg/cm2) formaldehyde instead of 1.0% (0.30 mg/cm2) detects significantly more contact allerg

    DEFF Research Database (Denmark)

    Pontén, Ann; Aalto-Korte, Kristiina; Agner, Tove

    2013-01-01

    .To validate earlier patch test results for comparison of 1% (wt/vol) and 2% (wt/vol) formaldehyde in water, and to investigate co-reactivity with quaternium-15. Materials and methods.In 12 dermatology clinics, 3591 patients were routinely patch tested simultaneously with 2.0% (wt/vol) (0.60 mg/cm(2) ) and 1.......0% (wt/vol) (0.30 mg/cm(2) ) formaldehyde. Micropipettes were used for delivering the exact dosage of the allergen. Results.Significantly more patients reacted to 2.0% formaldehyde than to 1.0% (3.4% versus 1.8%, p 2.0......% and 1.0%. Of 25 quaternium-15-positive patients, 4 (0.1%) reacted positively without reacting to formaldehyde. Conclusion.On the basis of the results of this multicentre study, as well as of previous studies, it can be suggested that 2.0% (wt/vol) in water formaldehyde should be used in routine patch...

  1. Patching for corneal abrasion.

    Science.gov (United States)

    Lim, Chris H L; Turner, Angus; Lim, Blanche X

    2016-07-26

    Published audits have demonstrated that corneal abrasions are a common presenting eye complaint. Eye patches are often recommended for treating corneal abrasions despite the lack of evidence for their use. This systematic review was conducted to determine the effects of the eye patch when used to treat corneal abrasions. The objective of this review was to assess the effects of patching for corneal abrasion on healing and pain relief. We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2016, Issue 4), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to May 2016), EMBASE (January 1980 to May 2016), Latin American and Caribbean Health Sciences Literature Database (LILACS) (January 1982 to May 2016), System for Information on Grey Literature in Europe (OpenGrey) (January 1995 to May 2016), the ISRCTN registry (www.isrctn.com/editAdvancedSearch), ClinicalTrials.gov (www.clinicaltrials.gov) and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 9 May 2016. We also searched the reference lists of included studies, unpublished 'grey' literature and conference proceedings and contacted pharmaceutical companies for details of unpublished trials. We included randomised and quasi-randomised controlled trials that compared patching the eye with no patching to treat simple corneal abrasions. Two authors independently assessed the risk of bias and extracted data. Investigators were contacted for further information regarding the quality of trials. The primary outcome was healing at 24, 48 and 72 hours while secondary outcomes included measures of pain, quality of life and adverse effects. We graded the certainty of the evidence using GRADE. We included 12 trials which

  2. Polar Cap Patch Dynamics

    Science.gov (United States)

    2013-04-25

    cap arcs Citation: Hosokawa, K., J. I. Moen, K. Shiokawa, and Y. Otsuka ( 2011 ), Motion of polar cap arcs , J. Geophys. Res. , 116 , A01305, doi...K., J. I. Moen, K. Shiokawa, and Y. Otsuka , (2011), Decay of polar cap patch, J. Geophys. Res., 116, A05308, doi:10.1029/2010JA016287, Abstract. We

  3. Century Tide Nicotine Patch

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Century Tide Nicotine Patch, a hi-tech smoking control therapy, is designed in accordance with the scientific principle of nicotine replacement. The therapy is promoted by the World Health Organization. Meanwhile, it also integrates traditional Chinese medical therapy and adopts advanced TTS technology.

  4. Testing the concurrent validity of a naturalistic upper extremity reaching task.

    Science.gov (United States)

    Schaefer, S Y; Hengge, C R

    2016-01-01

    Point-to-point reaching has been widely used to study upper extremity motor control. We have been developing a naturalistic reaching task that adds tool manipulation and object transport to this established paradigm. The purpose of this study was to determine the concurrent validity of a naturalistic reaching task in a sample of healthy adults. This task was compared to the criterion measure of standard point-to-point reaching. Twenty-eight adults performed unconstrained out-and-back movements in three different directions relative to constant start location along midline using their nondominant arm. In the naturalistic task, participants manipulated a tool to transport objects sequentially between physical targets anchored to the planar workspace. In the standard task, participants moved a digital cursor sequentially between virtual targets, veridical to the planar workspace. In both tasks, the primary measure of performance was trial time, which indicated the time to complete 15 reaches (five cycles of three reaches/target). Two other comparator tasks were also designed to test concurrent validity when components of the naturalistic task were added to the standard task. Spearman's rank correlation coefficients indicated minimal relationship between the naturalistic and standard tasks due to differences in progressive task difficulty. Accounting for this yielded a moderate linear relationship, indicating concurrent validity. The comparator tasks were also related to both the standard and naturalistic task. Thus, the principles of motor control and learning that have been established by the wealth of point-to-point reaching studies can still be applied to the naturalistic task to a certain extent.

  5. Reliability of the Quality of Upper Extremity Skills Test for Children with Cerebral Palsy Aged 2 to 12 Years

    Science.gov (United States)

    Thorley, Megan; Lannin, Natasha; Cusick, Anne; Novak, Iona; Boyd, Roslyn

    2012-01-01

    Aim: To investigate reliability of the Quality of Upper Extremity Skills Test (QUEST) scores for children with cerebral palsy (CP) aged 2-12 years. Method: Thirty-one QUESTs from 24 children with CP were rated once by two raters and twice by one rater. Internal consistency of total scores, inter- and intra-rater reliability findings for total,…

  6. Analysis of Photo-Patch Testing of Chlorpromazine and Sulfanilamide%氯丙嗪和磺胺光斑贴试验分析

    Institute of Scientific and Technical Information of China (English)

    高露娟; 胡跃; 倪春雅; 徐昱; 马莉; 严淑贤; 窦侠

    2015-01-01

    目的:通过光斑贴试验分析氯丙嗪和磺胺引起光变应性接触性皮炎(photo‐allergic contact dermatitis ,PACD )的情况。方法:选择2006年1月—2012年12月在复旦大学附属华山医院接受光斑贴试验的光皮肤病患者。根据国际接触性皮炎研究组(ICDRG )的标准判读光斑贴试验结果。比较两种变应原PACD阳性率及每种变应原的PACD阳性率在不同性别、不同年龄段光皮肤病患者中的差异。结果:共4836例入组,其中接受氯丙嗪光斑贴试验者3993例,PACD阳性率44.3%;接受磺胺光斑贴试验者4836例,PACD阳性率6.9%;两种变应差异( P<0.0001)。接受氯丙嗪光斑贴试验的3993例中,男性PACD阳性率43.6%,女性阳性率44.7%,差异无统计学意义( P=0.51);接受磺胺光斑贴试验的4836例中,男性 PACD阳性率9.3%,女性阳性率5.4%,差异有统计学意义( P<0.0001)。氯丙嗪PACD阳性率随年龄增加而升高,不同年龄段间差异有统计学意义(P<0.0001);磺胺PACD阳性率在不同年龄段间差异无统计学意义(P=0.37)。结论:氯丙嗪 PACD阳性率明显高于磺胺。氯丙嗪PACD多见于中老年人。男性光皮肤病患者中磺胺PACD阳性率高于女性。%Objective:To investigate the incidence of photo‐allergic contact dermatitis (PACD)induced by chlorpromazine and sulfanilamide with photo‐patch testing (PPT ) .Methods :Patients who underwent PPT for suspected photo dermatoses in Huashan Hospital ,Fudan University from January 2006 to December 2012 were selected .PPT results were evaluated with the criteria of International Contact Dermatitis Research Group (ICDRG) .Photoallergic positive rate was compared between two allergen groups .And the photoallergic positive rate of each allergen was compared among different genders and ages .Results:A total of 4836 patients were enrolled .PACD positive rate was

  7. Boolean Operations with Prism Algebraic Patches

    Science.gov (United States)

    Bajaj, Chandrajit; Paoluzzi, Alberto; Portuesi, Simone; Lei, Na; Zhao, Wenqi

    2009-01-01

    In this paper we discuss a symbolic-numeric algorithm for Boolean operations, closed in the algebra of curved polyhedra whose boundary is triangulated with algebraic patches (A-patches). This approach uses a linear polyhedron as a first approximation of both the arguments and the result. On each triangle of a boundary representation of such linear approximation, a piecewise cubic algebraic interpolant is built, using a C1-continuous prism algebraic patch (prism A-patch) that interpolates the three triangle vertices, with given normal vectors. The boundary representation only stores the vertices of the initial triangulation and their external vertex normals. In order to represent also flat and/or sharp local features, the corresponding normal-per-face and/or normal-per-edge may be also given, respectively. The topology is described by storing, for each curved triangle, the two triples of pointers to incident vertices and to adjacent triangles. For each triangle, a scaffolding prism is built, produced by its extreme vertices and normals, which provides a containment volume for the curved interpolating A-patch. When looking for the result of a regularized Boolean operation, the 0-set of a tri-variate polynomial within each such prism is generated, and intersected with the analogous 0-sets of the other curved polyhedron, when two prisms have non-empty intersection. The intersection curves of the boundaries are traced and used to decompose each boundary into the 3 standard classes of subpatches, denoted in, out and on. While tracing the intersection curves, the locally refined triangulation of intersecting patches is produced, and added to the boundary representation. PMID:21516262

  8. Investigation of the effects of mirror therapy on the upper extremity functions of stroke patients using the manual function test

    OpenAIRE

    Kim, Hwanhee; Shim, Jemyung

    2015-01-01

    [Purpose] The purpose of this study was to investigate the effects of mirror therapy on the upper extremity functions of stroke patients. [Subjects] The subjects of this study were 14 hemiplegia patients (8 males, 6 females; 9 infarction, 5 hemorrhage; 8 right hemiplegia, 6 left hemiplegia) who voluntarily consented to participate in the study. [Methods] The Korean version of the manual function test (MFT) was used in this study. The test was performed in the following order: arm movement (4 ...

  9. Materials research in the solar furnace. Materials testing in extreme conditions; Materialforschung im Sonnenofen. Werkstoffpruefung unter extremen Bedingungen

    Energy Technology Data Exchange (ETDEWEB)

    Schmuecker, M. [DLR-Institut fuer Werkstoff-Forschung, Koeln-Porz (Germany)

    2005-01-01

    Extreme temperatures can be achieved with concentrated solar radiation. High heating and cooling rates are possible, and furnace walls are not required. This makes the solar furnace a unique tool for testing of high-temperature materials as cooperations with the DLR Institute of Materials Research have shown. (orig.) [German] Mit konzentrierter Sonnenstrahlung koennen extreme Temperaturen erreicht werden. Hohe Aufheiz- und Abkuehlraten sind moeglich; im Allgemeinen kann auf begrenzende Ofenwandungen verzichtet werden. Damit stellt der Sonnenofen, in Verbindung mit einer geeigneten Mess- und Regeltechnik, ein einzigartiges Pruefwerkzeug fuer Hochtemperaturwerkstoffe dar, wie Kooperationen mit dem DLR-Institut fuer Werkstoff-Forschung gezeigt haben. (orig.)

  10. THE RELATION OF CHEMICAL STRUCTURE IN CATECHOL COMPOUNDS AND DERIVATIVES TO POISON IVY HYPERSENSITIVENESS IN MAN AS SHOWN BY THE PATCH TEST.

    Science.gov (United States)

    Keil, H; Wasserman, D; Dawson, C R

    1944-10-01

    1. Additional evidence is presented in support of the view which postulates a close chemical and biologic relation between the active ingredients in poison ivy and Japan lac. 2. Biologic evidence, based on the use of the patch test in man, is presented in support of the view that the active ingredient in poison ivy is a catechol derivative with a long, unsaturated side-chain in the 3-position. 3. Of the catechol compounds and derivatives studied, group reactions in patients sensitive to poison ivy leaves or extract were exhibited by the following compounds: 3-pentadecyl catechol (100 per cent of 21 cases), 4-pentadecyl catechol (38 per cent of 21 cases), "urushiol" dimethyl ether (33 per cent of 33 cases), 3-pentadecenyl-1'-veratrole (21 per cent of 14 cases), 3-methyl catechol (14 per cent of 21 cases), and hydrourushiol dimethyl ether (10 per cent of 20 cases). It has been found that 3-geranyl catechol shows a practically constant group reactivity in persons sensitive to poison ivy. 4. The uniformly positive group reaction to 3-pentadecyl catechol is notable since this substance possesses a saturated side-chain, whereas the active ingredient in poison ivy is known to have an unsaturated side-chain. 5. The group reactivity was not restricted to the 3-position, for in some instances 4-pentadecyl catechol also gave group reactions which, however, were less intense and less frequent than those shown by 3-pentadecyl catechol. This indicates that in some cases a long side-chain in the 4 position may be effective in producing group specific reactions. 6. Only an occasional person showed sensitiveness to 3-methyl catechol (short side-chain), and in one instance the group reactivity appeared to be specific for the 3-position. 7. The position of the side-chain in the catechol configuration has some bearing on the degree and incidence of group reactions in persons hypersensitive to poison ivy. 8. Evidence is presented to indicate that the introduction of double bonds in the

  11. Cramer-von Mises and Anderson-Darling goodness of fit tests for extreme value distributions with unknown parameters

    Science.gov (United States)

    Laio, Francesco

    2004-09-01

    The use of goodness of fit tests based on Cramer-von Mises and Anderson-Darling statistics is discussed, with reference to the composite hypothesis that a sample of observations comes from a distribution, FH, whose parameters are unspecified. When this is the case, the critical region of the test has to be redetermined for each hypothetical distribution FH. To avoid this difficulty, a transformation is proposed that produces a new test statistic which is independent of FH. This transformation involves three coefficients that are determined using the asymptotic theory of tests based on the empirical distribution function. A single table of coefficients is thus sufficient for carrying out the test with different hypothetical distributions; a set of probability models of common use in extreme value analysis is considered here, including the following: extreme value 1 and 2, normal and lognormal, generalized extreme value, three-parameter gamma, and log-Pearson type 3, in all cases with parameters estimated using maximum likelihood. Monte Carlo simulations are used to determine small sample corrections and to assess the power of the tests compared to alternative approaches.

  12. Oceanographic data collected during the EX1301 (Ship Shakedown and Patch Test Exploration, NE Canyons and Seamounts) expedition on NOAA Ship OKEANOS EXPLORER in the North Atlantic Ocean from 2013-03-18 to 2013-04-05 (NODC Accession 0107211)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Following annual ship shakedown and patch tests, EX1301 completed the comprehensive mapping of the Northeast canyons and the adjacent continental shelf carried out...

  13. Fault Tolerant Magnetic Bearing Testing and Conical Magnetic Bearing Development for Extreme Temperature Environments

    Science.gov (United States)

    Keith, Theo G., Jr.; Clark, Daniel

    2004-01-01

    During the six month tenure of the grant, activities included continued research of hydrostatic bearings as a viable backup-bearing solution for a magnetically levitated shaft system in extreme temperature environments (1000 F), developmental upgrades of the fault-tolerant magnetic bearing rig at the NASA Glenn Research Center, and assisting in the development of a conical magnetic bearing for extreme temperature environments, particularly turbomachinery. It leveraged work from the ongoing Smart Efficient Components (SEC) and the Turbine-Based Combined Cycle (TBCC) program at NASA Glenn Research Center. The effort was useful in providing technology for more efficient and powerful gas turbine engines.

  14. Security of Patched DNS

    CERN Document Server

    Herzberg, Amir

    2012-01-01

    In spite of the availability of DNSSEC, which protects against cache poisoning even by MitM attackers, many caching DNS resolvers still rely for their security against poisoning on merely validating that DNS responses contain some 'unpredictable' values, copied from the re- quest. These values include the 16 bit identifier field, and other fields, randomised and validated by different 'patches' to DNS. We investigate the prominent patches, and show how attackers can circumvent all of them, namely: - We show how attackers can circumvent source port randomisation, in the (common) case where the resolver connects to the Internet via different NAT devices. - We show how attackers can circumvent IP address randomisation, using some (standard-conforming) resolvers. - We show how attackers can circumvent query randomisation, including both randomisation by prepending a random nonce and case randomisation (0x20 encoding). We present countermeasures preventing our attacks; however, we believe that our attacks provide ...

  15. Testing the extreme male brain theory of autism spectrum disorder in a familial design

    NARCIS (Netherlands)

    Hauth, I.; Bruijn, Y.G. de; Staal, W.G.; Buitelaar, J.; Rommelse, N.N.

    2014-01-01

    Autism Spectrum Disorder (ASD) may be an extreme manifestation of some male-typical traits in both neuroanatomy and cognition. Using the ratio of the second to fourth digit (2D:4D) and digit length as biomarkers of (pre- and postnatal) testosterone levels, examined was whether hypermasculinized digi

  16. Allergic contact dermatitis pattern in Kuwait: nickel leads the pack. In-depth analysis of nickel allergy based on the results from a large prospective patch test series report

    Directory of Open Access Journals (Sweden)

    Nawaf Almutairi

    2017-05-01

    Full Text Available Introduction : Contact dermatitis is a relatively common dermatosis reported among several population groups from all around the globe. However, the data from Kuwait is unavailable. Patch tests are essential for the diagnosis of contact sensitization. Aim : To determine a relative frequency and pattern of sensitizers to different allergens in patients of suspected contact dermatitis in Kuwait and, also to study the role of the commonest sensitizer in detail. Material and methods: Patch tests were performed in 2461 consecutive patients with a clinical diagnosis of contact dermatitis seen at our hospital between September 1, 2014 and August 31, 2015. Out of the total of 1381 (56.1% patients with positive patch test results to at least one allergen, 546 (22.2% patients with a single positive reaction to nickel only (single largest sensitizer were selected as the study population for further detailed analysis. Results : At least one positive patch test reaction was found in 1381 (56.12% patients. Nickel was found to be the most common sensitizer seen in 546 (40% patients. The mean age was 37.3 ±13.8 years and the mean duration of disease was 27.3 ±13.8 months. Most (387/546 patients sensitized were females. The forearms/hands and wrists were the most prevalent sites (52.56% of the participants. In 58.91% of women, dermatitis was more often confined to other sites, mostly ears and the neck due to earrings and necklaces. Just more than half of the number (51.09% of nickel allergic patients were found in the age group of 15–25 years. Hairdressers/beauticians were the most affected group followed by house workers (housewives, cleaners, housekeepers. Conclusions : Nickel is the single most common sensitizer found in our patients, and female sex, young age, occupation with long hours of contact to nickel are high risk factors. We recommend that a directive, which limits the release of nickel from products with extended skin contact, be approved in

  17. Evaluation of the field tests of flexibility of the lower extremity: reliability and the concurrent and factorial validity.

    Science.gov (United States)

    Bozic, Predrag R; Pazin, Nemanja R; Berjan, Bobana B; Planic, Nenad M; Cuk, Ivan D

    2010-09-01

    The purpose of this study was to evaluate the standard field tests of flexibility of the lower extremity through their (a) intratrial and test-retest reliability, (b) concurrent validity with respect to a high-precision 3D system for kinematic recording, and (c) factorial validity. Physically active men (n = 84) were tested over 2 separate sessions by means of standard simple devices (kinanthropometry, ruler, and protractor) on the following flexibility tests: leg raise in a supine position, hip abduction test, single-legged knee bend (SLKB), sideward leg splits (SdLS), sit and reach (SR), sideways leg splits, and lengthwise leg splits. Additionally, 17 participants were simultaneously tested by means of a laboratory 3D kinematic analysis system. Most of the tests demonstrated high intratrial and test-retest reliability and concurrent validity. The exceptions were SLKB and SR tests that revealed not only a somewhat lower reliability but also a lower concurrent validity. For estimation of factorial validity, we applied a principal component analysis of the intercorrelations among the evaluated flexibility tests that revealed a single extracted principal component. Strong mutual relationships among them also suggest that very few of them, if not a single one, should be applied within the standard batteries of physical performance tests. We particularly recommend using SdLS over the most frequently used SR not only because of its relatively high reliability and validity but also because of its postural properties. Finally, we conclude that most of the standard field tests of flexibility of the lower extremity based on using inexpensive field equipment could be both reliable and valid and, therefore, justified for use in routine testing.

  18. Understanding patch departure rules for large carnivores: lion movements support a patch-disturbance hypothesis.

    Science.gov (United States)

    Valeix, Marion; Chamaillé-Jammes, Simon; Loveridge, Andrew J; Davidson, Zeke; Hunt, Jane E; Madzikanda, Hillary; Macdonald, David W

    2011-08-01

    We test two hypotheses that could account for patch departure by large mammalian carnivores. One hypothesis is the unsuccessful-hunt hypothesis, where carnivores leave an area after an unsuccessful hunt but continue hunting in the same area after a successful hunt. The second hypothesis is the patch-disturbance hypothesis, where carnivores depart the area after a successful hunt because of behavioral responses of prey to predator presence. We used global positioning system collars to monitor the movements of African lions (Panthera leo) and identified their kill sites to distinguish between these two hypotheses. Lions moved to a different area (≥ 5 km away) after 87% of the kills, which supports the patch-disturbance hypothesis for patch-departure behavior of large mammalian carnivores.

  19. Older women with dementia can perform fast alternating forearm movements and performance is correlated with tests of lower extremity function

    Directory of Open Access Journals (Sweden)

    Bramell-Risberg E

    2013-02-01

    Full Text Available Eva Bramell-Risberg,1 Gun-Britt Jarnlo,2 Sölve Elmståhl11Division of Geriatric Medicine, 2Division of Physiotherapy, Department of Health Sciences, Lund University, Lund, SwedenBackground: The purpose of this work was to study the performance and reliability of a test of fast alternating forearm movements and its relationship with measures of lower extremity function in older women with dementia.Methods: Fast alternating movements was studied in 26 female patients (mean age 81.7 ± 5.9 years with dementia and 34 controls (mean age 87.5 ± 4.7 years. Subgroup analyses for those aged 80–89 years were performed due to significant differences in the mean ages of the study groups. Test–retest reliability for alternating forearm movements was studied in 11 patients (mean age 80.3 ± 6.7 years and 10 controls (mean age 87.4 ± 1.6 years. Pulses generated were transformed to an analog signal shown on a modified electrocardiogram. Numbers of cycles at 10 and 15 seconds were calculated for the right and left hand. Walking 2 × 15 m and the Get-Up-and Go (GUG test were performed at self-selected and maximal speed. Associations between tests of upper and lower extremity function were sought in eight patients (mean age 85 ± 2.7 years and 16 controls (mean age 85.1 ± 2.8 years and also according to types of dementia in nine patients with probable Alzheimer's disease and 10 patients with other types of dementia.Results: Patients with dementia could perform the test and had significantly fewer cycles (P = 0.02–0.006 at both 10 and 15 seconds compared with controls after age adjustment. A higher number of cycles was associated with higher self-selected walking speeds in patients (r = -0.79. Test–retest reliability for alternating forearm movements was high for both patients (intraclass correlation 0.88–0.94 and controls (intraclass correlation 0.74–0.94.Conclusion: Alternating forearm movements at fast speed can be used as a reliable test in both

  20. Pitting Corrosion Characterization of Wrought Stellite Alloys in Green Death Solution with Immersion Test and Extreme Value Analysis Model

    Science.gov (United States)

    Zhang, X. Z.; Liu, R.; Chen, K. Y.; Yao, M. X.

    2014-05-01

    This article presents a study of the corrosion behavior of two wrought Stellite alloys, Stellite 6B, and Stellite 6K, in Green Death solution, utilizing the extreme value analysis (EVA) model, which is a statistics tool developed based on the Gumbel distribution. Green Death solution a typical oxidized testing solution used in industry for assessing the corrosion resistance of materials. The data of maximum pit depths are obtained from the immersion tests on these alloys for various exposure periods. The top ten maximum pit depths in each specimen surface after the immersion test are measured using a surface texture and contour measuring instrument. These data are the input parameters of the EVA model and the outcomes of the model are the extreme values (minimum thickness) required for the alloys under a given service condition. It is shown that Stellite 6K, which contains higher carbon content but smaller-size carbides, exhibits better corrosion resistance in regard to the extreme value. The results and mechanisms of Stellite 6B and Stellite 6K in Green Death solution corrosion are discussed.

  1. Patch antenna terahertz photodetectors

    Energy Technology Data Exchange (ETDEWEB)

    Palaferri, D.; Todorov, Y., E-mail: yanko.todorov@univ-paris-diderot.fr; Chen, Y. N.; Madeo, J.; Vasanelli, A.; Sirtori, C. [Laboratoire Matériaux et Phénomènes Quantiques, Université Paris Diderot, Sorbonne Paris Cité, CNRS-UMS 7162, 75013 Paris (France); Li, L. H.; Davies, A. G.; Linfield, E. H. [School of Electronic and Electrical Engineering, University of Leeds, Leeds LS2 9JT (United Kingdom)

    2015-04-20

    We report on the implementation of 5 THz quantum well photodetector exploiting a patch antenna cavity array. The benefit of our plasmonic architecture on the detector performance is assessed by comparing it with detectors made using the same quantum well absorbing region, but processed into a standard 45° polished facet mesa. Our results demonstrate a clear improvement in responsivity, polarization insensitivity, and background limited performance. Peak detectivities in excess of 5 × 10{sup 12} cmHz{sup 1/2}/W have been obtained, a value comparable with that of the best cryogenic cooled bolometers.

  2. Patch based predation in a southern Appalachian stream

    Science.gov (United States)

    C.A. Gibson; R.E. Ratajezak; G.D. Grossman

    2004-01-01

    Streams are characterized by high degrees of patchiness that could influence the role of predators in these systems. Here we assess the impact of predatory benthic fishes on benthic macroinvertebrate density, biomass, and community structure at the patch scale in a fourth order stream in the southern Appalachians. We tested the role of predation in two different patch...

  3. Collaboratively Patching Linked Data

    CERN Document Server

    Knuth, Magnus; Sack, Harald

    2012-01-01

    Today's Web of Data is noisy. Linked Data often needs extensive preprocessing to enable efficient use of heterogeneous resources. While consistent and valid data provides the key to efficient data processing and aggregation we are facing two main challenges: (1st) Identification of erroneous facts and tracking their origins in dynamically connected datasets is a difficult task, and (2nd) efforts in the curation of deficient facts in Linked Data are exchanged rather rarely. Since erroneous data often is duplicated and (re-)distributed by mashup applications it is not only the responsibility of a few original publishers to keep their data tidy, but progresses to be a mission for all distributers and consumers of Linked Data too. We present a new approach to expose and to reuse patches on erroneous data to enhance and to add quality information to the Web of Data. The feasibility of our approach is demonstrated by example of a collaborative game that patches statements in DBpedia data and provides notifications ...

  4. Statistics for Patch Observations

    Science.gov (United States)

    Hingee, K. L.

    2016-06-01

    In the application of remote sensing it is common to investigate processes that generate patches of material. This is especially true when using categorical land cover or land use maps. Here we view some existing tools, landscape pattern indices (LPI), as non-parametric estimators of random closed sets (RACS). This RACS framework enables LPIs to be studied rigorously. A RACS is any random process that generates a closed set, which encompasses any processes that result in binary (two-class) land cover maps. RACS theory, and methods in the underlying field of stochastic geometry, are particularly well suited to high-resolution remote sensing where objects extend across tens of pixels, and the shapes and orientations of patches are symptomatic of underlying processes. For some LPI this field already contains variance information and border correction techniques. After introducing RACS theory we discuss the core area LPI in detail. It is closely related to the spherical contact distribution leading to conditional variants, a new version of contagion, variance information and multiple border-corrected estimators. We demonstrate some of these findings on high resolution tree canopy data.

  5. Temporary Thermocouple Attachment for Thermal/Vacuum Testing at Non-Extreme Temperatures

    Science.gov (United States)

    Ungar, Eugene K.; Wright, Sarah E.

    2016-01-01

    Post-test examination and data analysis that followed a two week long vacuum test showed that numerous self-stick thermocouples became detached from the test article. The thermocouples were reattached with thermally conductive epoxy and the test was repeated to obtain the required data. Because the thermocouple detachment resulted in significant expense and rework, it was decided to investigate the temporary attachment methods used around NASA and to perform a test to assess their efficacy. The present work describes the original test and the analysis that showed that the thermocouples had become detached, temporary thermocouple attachment methods assessed in the retest and in the thermocouple attachment test, and makes a recommendation for attachment methods for future tests.

  6. Strategic Analysis for Patch Ltd.

    OpenAIRE

    Louis, Owen

    2012-01-01

    This paper is a strategic analysis for the start-up Patch Ltd. Patch has developed innovative products for growing produce in homes and will compete in the consumer containergrowing industry. The industry and the company are introduced along with urban agriculture trends. The industry is analysed using Porter’s 5 forces analysis, and a competitive analysis compares Patch to its competitors in key success factors found in the 5 forces analysis. A strategy is developed using opportunities and t...

  7. A prospective comparison of pedal ergometry with conventional treadmill testing in the investigation of lower extremity pain.

    LENUS (Irish Health Repository)

    Manning, B J

    2012-02-03

    BACKGROUND: Investigation of lower extremity pain is compromised by comorbid disorders that may interfere with conventional testing. AIMS: To compare pedal ergometry with conventional treadmill testing. METHODS: A prospective study was performed where patients presenting with a diagnosis of intermittent claudication were assessed by both methods of testing. RESULTS: Of 78 patients studied with both tests, no exercise-induced ankle pressure changes occurred in 26, two were unable to complete either test despite normal pressure measurements, while 24 had exercise-induced pressure drop detected by both tests. Of patients who completed pedal ergometry, 21 were unable to complete the treadmill test, 14 of whom had negative ergometry, while seven had a pressure drop detected by pedal ergometry. Three had pressure changes with pedal ergometry, but not with treadmill testing and two had pressure changes on the treadmill not reproduced by pedal ergometry. CONCLUSIONS: Pedal ergometer is more sensitive than treadmill testing in detecting arterial insufficiency, as indicated by a 20% or greater fall in ankle pressure, and more suitable in a subgroup of patients unable to tolerate conventional treadmill testing.

  8. Testing the usefulness of hydrological models in simulating extreme streamflows for frequency analysis purpose

    Science.gov (United States)

    Chen, H.; Li, L.; Wang, J.; Xu, C.-Y.; Guo, S.

    2012-04-01

    Recently, extreme flood events are becoming more uncertain and greater challenge in the world. Flood frequency analysis is a powerful tool to study and evaluate extreme flood events, and also a key step in design of water resources projects. Hydrological models have been used as an important tool for forecasting extreme flood event and design flood calculation. However, there are little studies on evaluation of the reasonability of flood frequency values obtained from runoff simulations of watershed hydrological models. In this study, the reasonability of the flood frequency analysis obtained from runoff simulations of different hydrological models is evaluated and analyzed by comparison with that from historical runoff observation. Xiangjiang basin, one of the most important economic belts in Hunan Province, is selected as the study region. Xiangjiang basin is always in a severe situation for flood control in summer and has also great influences on Dongting Lake's flood storage capacity. In this study Xiangjiang Basin was divided into 3 sub-basins and 1 downstream section, which have their outflow stations respectively. Each region has integrated and long observed historical runoff and rainfall series from 1961 to 2005. Three conceptual hydrological models, i.e., Xin-anjiang, HBV and WASMOD were established to simulate runoff in each sub-basins of Xiangjiang basin. To utilize the simulations from three hydrological models for frequency analysis, a transformation from deterministic rain-runoff models to stochastic models is needed by adding the model residuals to the simulated discharges using Monte-Carlo method. The commonly used Pearson type III distribution in China and L-moment were used to calculate the frequency. All three hydrological models perform well according to commonly used model evaluation criteria, i.e., Nash-Sutcliffe model efficiency coefficient and water balance error, etc. However, the frequency analysis results of annual maximum flow simulated

  9. Results of Patch-Tests from Santa Casa de Belo Horizonte Dermatology Clinic, Belo Horizonte, Brazil, from 2003 to 2010 Resultados de Testes de Contato da Clínica Dermatológica da Santa Casa de Belo Horizonte, Belo Horizonte, Brasil, de 2003 a 2010

    Directory of Open Access Journals (Sweden)

    Dulcilea Ferraz Rodrigues

    2012-10-01

    Full Text Available This Dermatology Clinic tests referred patients who have suspected allergic contact dermatitis. The patch-test results (1406 patients from July 1st, 2003 to June 30th, 2010 will be reported and compared to the data from the Brazilian Contact Dermatitis Study Group (GBEDC. A standardized patch test (30 allergens was used in all of these patients. Depending on the complaint and suspected allergen another battery was also used (cosmetic battery.The most frequent allergens of Brazilian Standard Patch Test Series and Cosmetic Brazilian Standard Patch Test Series were nickel and tosylamide formaldehyde resin, respectively. Allergic contact dermatitis was the final diagnosis in 58.2%. Studies about allergen frequency may enable the performance of prevention programmes.Esta Clínica Dermatológica realiza testes de contato em pacientes encaminhados com suspeita de dermatite alérgica de contato. Os resultados de testes de contato (1406 pacientes, realizados no período de 1/07/2003 a 30/06/2010, serão descritos e comparados aos dados do Grupo Brasileiro de Estudo em Dermatite de Contato. Uma bateria de teste de contato padronizada (30 alérgenos foi usada em todos esses pacientes. Dependendo da queixa e do alérgeno suspeito, outra bateria(cosméticos foi testada. Os alérgenos mais frequentes das Baterias Padrão e Cosméticos foram níquel e resina-tonsilamida formaldeído, respectivamente. Dermatite alérgica de contato foi o diagnóstico final em 58.2%. Estudos sobre frequência de alérgenos podem viabilizar programas preventivos.

  10. FORMULATION AND EVALUATION OF CARVEDILOL TRANSDERMAL PATCHES

    Directory of Open Access Journals (Sweden)

    Mandal Sonjoy

    2011-01-01

    Full Text Available The present study was carried out to develop and evaluate matrix-type transdermal formulations containing carvedilol with different ratios of hydrophilic (HPMC and hydrophobic polymeric (Eudragit RS100 combinations plasticized with glycerin and dibutyl pthalate by the solvent evaporation technique. Effect of surfactant (PEG-400 and Tween 80 and permeation enhancers (DMSO and DMF were studied. The interference of the polymers were ruled out by infrared and uv spectroscopic methods. Viscosity of the polymers was determined using Brookfield viscometer (LVDV-E. The partition coefficient study was performed using n-octanol as the organic phase and phosphate buffer pH 7.4 as an aqueous phase. The prepared patches were tested for their physicochemical characteristics such as thickness, weight, and drug content uniformity, swelling index, water vapour transmission, folding endurance, and tensile strength. In vitro release studies of carvedilol-loaded patches in phosphate buffer (pH, 7.4 exhibited drug release in the range of 80.70 to 98.56 % in 24 h. Data of in vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. The models used were zero and first-order equations, Hixon-Crowell, Higuchi and Korsmeyer-Peppas models. Based on physicochemical and in vitro release studies, patches containing HPMC and Eudragit RS 100 (DMSO as permeation enhancer were chosen for in vitro skin permeation studies which were performed using a modified diffusion cell across rat abdominal skin and showed first order release mechanism. Skin studies for the transdermal patches were assessed and were found to be free of irritation. The patches were subjected to short term stability studies and were found stable. Good correlation was observed (R2 = 0.810 with in vitro release Vs in vitro skin permeation studies.

  11. A importância das provas epicutâneas de contacto no diagnóstico diferencial de reações a medicamentos The importance of patch tests in the differential diagnosis of adverse drug reactions

    Directory of Open Access Journals (Sweden)

    Ana Rita Travassos

    2011-08-01

    Full Text Available O eritema exsudativo multiforme é uma erupção aguda, autolimitada, frequentemente associada a infecções (geralmente virais, doenças sistêmicas e fármacos. Apresenta-se o caso de uma mulher de 39 anos, com o diagnóstico de lúpus eritematoso sistêmico, que recorreu à Urgência com quadro de eritema exsudativo multiforme, com início 10 dias após tomar amoxicilina e ácido clavulânico por amigdalite e, quase simultaneamente, receber a vacina antipneumocócica. Colocou-se também a hipótese de síndrome de Rowell. Efetuaram-se testes epicutâneos de contacto com bateria básica (portuguesa e princípios ativos dos fármacos suspeitos (Chemotechnique®. Encontrou-se hipersensibilidade à amoxicilina 10% vas (++, à ampicilina 10% vas (++ e à penicilina G potássica 10% vas (+, atribuindo-se à amoxicilina a causa mais provável do eritema exsudativo multiformeExudative erythema multiforme is an acute self-limited skin disease often associated with infections (usually viral, and also with systemic diseases and drugs. We report the case of a 39-year-old woman diagnosed with systemic lupus erythematosus, who presented at the emergency clinic with exudative erythema multiforme which started 10 days after taking amoxicillin and clavulanic acid for tonsillitis together (almost simultaneously with the pneumococcal vaccine. Rowell's syndrome was also considered to be a possibility. Skin patch tests were carried with the standard battery of patches (GPEDC and the active ingredients of the suspected drugs (Chemotechnique ®, with readings at D2 and D3. The tests were positive for amoxicillin 10% pet (++, ampicillin 10% pet (+ + and penicillin G potassium 10% pet (+. We accepted the diagnosis of erythema multiforme due to amoxicillin, confirmed by patch testing

  12. 疑似面部化妆品变应性接触性皮炎58例斑贴试验%The Patch Test Results of 58 Cases of Suspected Facial Cosmetic Allergic Contact Dermatitis

    Institute of Scientific and Technical Information of China (English)

    郑结成; 徐宁; 张杰; 周静; 窦侠; 于波

    2016-01-01

    Objective To investigate cosmetic products related allergens and provide clinical guidance for suspected facial cosmetic allergic contact dermatitis patients.Methods Patch test of cosmetic series allergens was performed on 58 patients with suspected cosmetic allergic contact dermatitis.Thirty-seven patients were also tested by European standard series allergens at the same time.The positive reactions were determined according to the international contact dermatitis research group recommendation.Results Of the 58 patients patch test with cosmetic series, 34 (58.62%) patients showed at least one positive reaction.The most common allergen was Kathon CG (31.03%), which belonged to preservative allergens.Of the 37 patients patch test by European standard series allergens, 24 (64.86%) showed positive reactions.Conclusion Preservatives including Kathon CG, Methylisothiazolinone are the most common allergens inducing the cosmetic allergic contact dermatitis.%目的 调查化妆品相关变应原,为疑诊化妆品变应性接触性皮炎的患者进行临床治疗指导及预防.方法 对来自本科门诊的58例疑诊化妆品接触性皮炎患者进行化妆品系列变应原斑贴试验,部分患者同时进行欧洲标准系列变应原斑贴试验,按国际接触性皮炎研究组推荐标准判读结果.结果 58例患者中,化妆品系列斑贴试验阳性率58.62%,最常见的化妆品变应原为卡松CG(31.03%)及甲基异噻唑啉酮(29.31%),在所有的阳性反应中,防腐剂类变应原所占比例最高,为77.59%;欧洲标准系列的化妆品相关变应原中阳性率最高的为卡松CG(21.62%),标准系列中化妆品相关变应原与化妆品系列变应原阳性结果呈中等一致性.结论 防腐剂类是化妆品变应性接触性皮炎患者最主要的过敏原.

  13. The influence of subject and test design on dynamometric measurements of extremity muscles.

    Science.gov (United States)

    Keating, J L; Matyas, T A

    1996-08-01

    In the context of broader discussions of clinical dynamometry, earlier reviews have raised concerns about the potential effects of variations in subject factors and test procedures on measurements. None, however, have dealt exclusively with these effects. We therefore reviewed more than 200 articles to evaluate in detail the effects of variations in subject factors and test procedures on measurements. Factors relating to subjects that affected measurements were age, gender, weight, athletic background, disability, and limb dominance. Test conditions that led to variations in measurements were range of movement in which values were obtained, type of contraction or movement (concentric, eccentric, isokinetic, isometric, isotonic), pretest procedures (warm-up and gravity-correction procedures, starting position, stabilization, axes alignment, lever arm length, preload, damp/ramp settings), test conditions (speed, test sequence, rest intervals, feedback), and type of data analysis (the data selected and how they are manipulated). In the majority of the publications, the authors failed to provide sufficient detail for accurate replication of test procedures or for comparison with other studies. We advocate that the factors identified in this review be included whenever measurements obtained with a dynamometer are reported. Effective development of normative data, formation of ratios, comparison of measurements across studies, and relating measurements with other performance criteria (eg, measurements of functional performance) all require descriptions of variables relating to subjects and testing. Similarly, meaningful use of these measurements in clinical practice requires consideration and documentation of these variables.

  14. Nuclear power plant Olkiluoto 3. Containment leakage test under extreme conditions

    Energy Technology Data Exchange (ETDEWEB)

    Fleckenstein, Tobias [TUEV SUED Industrie Service GmbH, Munich (Germany). Measaruement Technology Dept.

    2015-01-15

    Modern nuclear power plants place high demands on the design and execution of safety checks. TUEV SUED supported the containment leakage test for the largest- capacity third generation nuclear power plant in the world - Olkiluoto 3 in Finland. The experts successfully met the challenges presented by exceptional parameters of the project. The containment of Olkiluoto 3 is unique in that the vessel's volume is 80,000 m{sup 3} while measurements were carried out over a period of ten days. To execute the test, 75 temperature and 15 humidity sensors had to be installed and correctly interlinked by more than ten kilometres of cable. These instruments also needed to withstand an absolute pressure of 6 bar, ambient temperatures of 30 C and high levels of humidity. These conditions required comprehensive preparation and a high amount of qualification tests. Parts of the qualifications were carried out at the autoclave system of the Technical University in Munich, Germany, where the project test conditions could be simulated. The software required to determine the tests was developed by TUEV SUED and verified by German's national accreditation body DAkkS under ISO 17025. TUEV SUED enabled the test schedule to continue without delay by analysing all recorded data continuously on site, including pressure, temperature, humidity and leakage mass flow curves. With the comprehensive preparation, data acquisition system recording measurements continuously and the on-time result calculation, all components of the leak-tightness assessment were successfully completed in accordance with requirements.

  15. Analysis of Patch Test Outcomes in 105 Patients with Skin Disease%105例皮炎、湿疹类皮肤病斑贴试验的结果分析

    Institute of Scientific and Technical Information of China (English)

    彭书莉; 王敏

    2011-01-01

    Objective To discuss the function of patch test in finding out the causes of skin diseases. Methods The patch tests were performed in 105 cases with dermatitis and eczema from April,2008 to October,2009, and the results were analyzed and compared. Results The patch test displayed positive results in 87 cases, the overall positive rate was 82.86% ;in which the positive rate of contact dermatitis, allergic dermatitis, eczema facial recurrent dermatitis, neurodermatitis and seborrheic dermatitis was 81.81% ( 27/33 ) ,72% ( 18/25 ) ,75% ( 18/24 ) ,62.5% ( 10/16 ) ,50% (2/4) and 33.33% ( 1/3 ), respectively. The material with the highest positive rate was potassium dichromate,followed by nickel sulfate and merthiolate. Conclusion The contact allergen plays a key role on arise and development of eczema and dermatitis,and the patch test is one of the most important methods on diagnosis of various skin diseases.%目的 探讨斑贴试验在寻找皮肤科常见疾病病因方面的应用.方法 对门诊2008年4月-2009年10月确诊为皮炎、湿疹类皮肤病的105例患者进行斑贴试验,并对各组间结果进行分析比较.结果 105例患者出现一项及以上阳性的87例,总阳性率82.86%;其中接触性皮炎阳性率27/33例(81.81%),过敏性皮炎阳性率18/25例(72%),湿疹阳性率18/24例(75%),面部复发性皮炎阳性率10/16例(62.5%),神经性皮炎阳性率2/4例(50%),脂溢性皮炎阳性率1/3例(33.33%);阳性率最高的物质为重铬酸钾为21/105(20%),其次为硫酸镍19/105(18.1%)、硫柳汞9/105(7.6%).结论 本研究证实在湿疹、皮炎类皮肤病的发生、发展中,接触性过敏原起着重要的作用,斑贴试验是目前多种皮肤病病因诊断的重要方法之一.

  16. Development of THOR-FLx: A Biofidelic Lower Extremity for Use with 5th Percentile Female Crash Test Dummies.

    Science.gov (United States)

    Shams, Tariq; Beach, David; Huang, Tsai-Jeon; Rangarajan, N; Haffner, Mark

    2002-11-01

    A new lower leg/ankle/foot system has been designed and fabricated to assess the potential for lower limb injuries to small females in the automotive crash environment. The new lower extremity can be retrofitted at present to the distal femur of the 5th percentile female Hybrid III dummy. Future plans are for integration of this design into the 5th percentile female THOR dummy now under development. The anthropometry of the lower leg and foot is based mainly on data developed by Robbins for the 5th percentile female, while the biomechanical response requirements are based upon scaling of 50th percentile male THOR-Lx responses. The design consists of the knee, tibia, ankle joints, foot, a representation of the Achilles tendon, and associated flesh/skins. The new lower extremity, known as THOR-FLx, is designed to be biofidelic under dynamic axial loading of the tibia, static and dynamic dorsiflexion, static plantarflexion and inversion/eversion. Instrumentation includes accelerometers, load cells, and rotary potentiometers to capture relevant kinematic and dynamic information from the foot and tibia. This paper will describe the performance requirements for THOR-FLx, the methodology used in its' development, results of component tests, and the biofidelity tests conducted on the full assembly.

  17. Conical Magnetic Bearing Development and Magnetic Bearing Testing for Extreme Temperature Environments

    Science.gov (United States)

    Keith, Theo G., Jr.; Jansen, Mark

    2004-01-01

    The main proposed research of this grant were: to design a high-temperature, conical magnetic bearing facility, to test the high-temperature, radial magnetic bearing facility to higher speeds, to investigate different backup bearing designs and materials, to retrofit the high-temperature test facility with a magnetic thrust bearing, to evaluate test bearings at various conditions, and test several lubricants using a spiral orbit tribometer. A high-temperature, conical magnetic bearing facility has been fully developed using Solidworks. The facility can reuse many of the parts of the current high-temperature, radial magnetic bearing, helping to reduce overall build costs. The facility has the ability to measure bearing force capacity in the X, Y, and Z directions through a novel bearing mounting design. The high temperature coils and laminations, a main component of the facility, are based upon the current radial design and can be fabricated at Texas A&M University. The coil design was highly successful in the radial magnetic bearing. Vendors were contacted about fabrication of the high temperature lamination stack. Stress analysis was done on the laminations. Some of the components were procured, but due to budget cuts, the facility build up was stopped.

  18. Polymer concrete patching materials

    Energy Technology Data Exchange (ETDEWEB)

    Fontana, J.J.

    1977-09-01

    The increased use of deicing salts is causing rapid deterioration of portland cement concrete bridge decks. Soluble chlorides cause corrosion of the steel reinforcing rods with a corresponding increase in volume of the rods. This expansion causes stresses in the concrete which result in delaminations and surface spalling. The repair of surface spalls with portland cement concrete can only be made if traffic can be avoided for several days. A patching material which would allow traffic to resume over the repaired area in a few hours was needed. Polymer concrete (PC) was developed to repair deteriorated portland cement concrete. Polymer concrete is defined as a composite material in which the aggregate is bound together in a dense matrix with a polymer binder. The aggregate is mixed with a monomer mixture and subsequently cured in place. Polymer concrete combines the premix characteristics of portland cement concrete with high strength, long term durability properties and fast cure times. PC placed at temperatures between 35/sup 0/F and 95/sup 0/F attains strengths greater than 5000 psi in 2 hours. The high early strength of PC is suitable for use in the repair of highway structures where traffic conditions allow closing of the area for only a few hours.

  19. Testing Single and Combinations of Amendments for Stabilization of Metals in Contrasting Extremely Contaminated Soils

    Directory of Open Access Journals (Sweden)

    Siebielec G.

    2013-04-01

    Full Text Available Metals can be stabilized by soil amendments that increase metals adsorption or alter their chemical forms. Such treatments may limit the risk related to the contamination through reduction of metal transfer to the food chain (reduction of metal uptake by plants and its availability to soil organisms and metals migration within the environment. There is a need for experiments comparing various soil amendments available at reasonable amounts under similar environmental conditions. The other question is whether all components of soil environment or soil functions are similarly protected after remediation treatment. We conducted a series of pot studies to test some traditional and novel amendments and their combinations. The treatments were tested for several highly Zn/Cd/Pb contaminated soils. Among traditional amendments composts were the most effective – they ensured plant growth, increased soil microbial activity, reduced Cd in earthworms, reduced Pb bioaccessibility and increased share of unavailable forms of Cd and Pb.

  20. SubPatch: random kd-tree on a sub-sampled patch set for nearest neighbor field estimation

    Science.gov (United States)

    Pedersoli, Fabrizio; Benini, Sergio; Adami, Nicola; Okuda, Masahiro; Leonardi, Riccardo

    2015-02-01

    We propose a new method to compute the approximate nearest-neighbors field (ANNF) between image pairs using random kd-tree and patch set sub-sampling. By exploiting image coherence we demonstrate that it is possible to reduce the number of patches on which we compute the ANNF, while maintaining high overall accuracy on the final result. Information on missing patches is then recovered by interpolation and propagation of good matches. The introduction of the sub-sampling factor on patch sets also allows for setting the desired trade off between accuracy and speed, providing a flexibility that lacks in state-of-the-art methods. Tests conducted on a public database prove that our algorithm achieves superior performance with respect to PatchMatch (PM) and Coherence Sensitivity Hashing (CSH) algorithms in a comparable computational time.

  1. Test Status for Proposed Coupling of a Gravitational Force to Extreme Type II YBCO Ceramic Superconductors

    Science.gov (United States)

    Noever, David; Li, Ning; Robertson, Tony; Koczor, Ron; Brantley, Whitt

    1999-01-01

    As a Bose condensate, superconductors provide novel conditions for revisiting previously proposed couplings between electromagnetism and gravity. Strong variations in Cooper pair electron density, large conductivity and low magnetic permeability define superconductive and degenerate condensates without the traditional density limits imposed by the Fermi energy (about 10-6 g/cu cm). Recent experiments have reported anomalous weight loss for a test mass suspended above a rotating Type II, YBCO superconductor, with the percentage change (0.05-2.1%) independent of the test mass' chemical composition and diamagnetic properties. A variation of 5 parts per 10(exp 4) was reported above a stationary (non-rotating) superconductor. In the present experiments reported using a sensitive gravimeter (resolution superconductors were stably levitated in a DC magnetic field (0.6 Tesla) subject to lateral AC fields (60 Gauss at 60 Hz) and rotation. With magnetic shielding, thermal control and buoyancy compensation, changes in acceleration were measured to be less than 2 parts in 10(exp 8) of the normal gravitational acceleration. This result puts new limits on the strength and range of the proposed coupling between high-Tc superconductors and gravity. Latest test results will be reported, along with status for future improvements and prospects.

  2. Test Status for Proposed Coupling of a Gravitational Force to Extreme Type II YBCO Ceramic Superconductors

    Science.gov (United States)

    Noever, David; Li, Ning; Robertson, Tony; Koczor, Ron; Brantley, Whitt

    1999-01-01

    As a Bose condensate, superconductors provide novel conditions for revisiting previously proposed couplings between electromagnetism and gravity. Strong variations in Cooper pair electron density, large conductivity and low magnetic permeability define superconductive and degenerate condensates without the traditional density limits imposed by the Fermi energy (about 10-6 g/cu cm). Recent experiments have reported anomalous weight loss for a test mass suspended above a rotating Type II, YBCO superconductor, with the percentage change (0.05-2.1%) independent of the test mass' chemical composition and diamagnetic properties. A variation of 5 parts per 10(exp 4) was reported above a stationary (non-rotating) superconductor. In the present experiments reported using a sensitive gravimeter (resolution YBCO superconductors were stably levitated in a DC magnetic field (0.6 Tesla) subject to lateral AC fields (60 Gauss at 60 Hz) and rotation. With magnetic shielding, thermal control and buoyancy compensation, changes in acceleration were measured to be less than 2 parts in 10(exp 8) of the normal gravitational acceleration. This result puts new limits on the strength and range of the proposed coupling between high-Tc superconductors and gravity. Latest test results will be reported, along with status for future improvements and prospects.

  3. *New* CRITICAL Windows Security patch

    CERN Multimedia

    2003-01-01

    On 10 September 2003, Microsoft issued a new CRITICAL security patch, MS03-039. It must be URGENTLY applied on ALL WINDOWS systems, which are not centrally managed for security patches. This includes Experiment computers, Home computers and Windows Portable and Desktop systems not running NICE. Details of the security hole and patch for MS03-039 (which also includes MS03-026) are at: http://cern.ch/it-div/news/hotfix-MS03-039.asp http://www.microsoft.com/technet/security/bulletin/MS03-039.asp

  4. *New*: CRITICAL Windows Security patch

    CERN Multimedia

    2003-01-01

    On 10 September 2003, Microsoft issued a new CRITICAL security patch, MS03-039. It must be URGENTLY applied on ALL WINDOWS systems, which are not centrally managed for security patches. This includes Experiment computers, Home computers and Windows Portable and Desktop systems not running NICE. Details of the security hole and patch for MS03-039 (which also includes MS03-026) are at: http://cern.ch/it-div/news/hotfix-MS03-039.asp http://www.microsoft.com/technet/security/bulletin/MS03-039.asp

  5. Toric degenerations of Bezier patches

    CERN Document Server

    Garcia-Puente, Luis David; Zhu, Chungang

    2010-01-01

    The control polygon of a Bezier curve is well-defined and meaningful---there is a sequence of weights under which the limiting position of the curve is the control polygon. For a Bezier surface patch, there are many possible polyhedral control structures, and none are canonical. We propose a not necessarily polyhedral control structure for surface patches, regular control surfaces, which are certain C^0 spline surfaces. While not unique, regular control surfaces are exactly the possible limiting positions of a Bezier patch when the weights are allowed to vary, but the control points are fixed.

  6. Does extreme environmental severity promote plant facilitation? An experimental field test in a subtropical coastal dune.

    Science.gov (United States)

    Castanho, Camila T; Oliveira, Alexandre A; Prado, Paulo Inácio K L

    2015-07-01

    The stress gradient hypothesis (SGH) postulates how the balance between plant competition and facilitation shifts along environmental gradients. Early formulations of the SGH predicted that facilitation should increase monotonically with stress. However, a recent theoretical refinement of the SGH postulates stronger facilitation under moderate stress, followed by a decreasing role of facilitation in the most severe environments. We conducted field experiments along the most severe part of a coastal dune gradient in southeast Brazil to test the effect of stress on the intensity and importance of the net interactions between two tree species. First, we compared the performance of distinct life stages of Ternstroemia brasiliensis in the presence and absence of Guapira opposita adults along a beach-to-inland gradient, a gradient of environmental severity. To test the effect of one stress factor in particular, we also manipulated water availability, a limiting resource due to the sandy soils. At the most severe part of the coastal gradient (i.e. closest to the seashore), both intensity and importance of the interaction between G. opposita and T. brasiliensis were negatively related to stress, with a pattern consistent across distinct life stages of the target species. However, the sign of the net interaction depended on the life stage of the target species. Our results provide empirical evidence that the role of facilitation tends to wane, leading to neutral or even negative net interactions between species as stress reaches its maximum, as predicted by the recent refinements of the SGH.

  7. An extremely sensitive species-specific ARMs PCR test for the presence of tiger bone DNA.

    Science.gov (United States)

    Wetton, Jon H; Tsang, Carol S F; Roney, Chris A; Spriggs, Adrian C

    2004-02-10

    The survival of the tiger (Panthera tigris) is seriously threatened by poaching to provide raw materials for Traditional Chinese Medicines (TCMs). Most highly prized are the tiger's bones, which are used in combination with other animal and plant derivatives in pills and plasters for the treatment of rheumatism and other ailments. Hundreds of patent remedies have been produced which claim to contain tiger bone, but proof of its presence is needed, if legislation prohibiting the trade in endangered species is to be enforced. A highly sensitive tiger-specific real-time PCR assay has been developed to address this problem. Using primers specific to the tiger mitochondrial cytochrome b gene, successful amplification has been reliably achieved from blood, hair and bone as well as from a range of TCMs spiked with 0.5% tiger bone. Although capable of detecting fewer than 10 substrate molecules, the seven varieties of TCM pills and plasters tested showed no detectable trace of tiger DNA before spiking. Furthermore, sequencing several "tiger bone" fragments seized from TCM shops has shown that they actually originated from cattle and pigs. The potential effects of traditional bone preparation methods, evidence that much lower concentrations are used than alleged on TCM packaging, and substitution of bones from other species all suggest a low likelihood of detecting tiger DNA in patent medicines. Despite this, the basic methods have been thoroughly proven and can be readily applied to derivatives from other CITES protected species providing a rapid and highly sensitive forensic test for species of origin. Potential applications to the monitoring of wild populations are demonstrated by the successful identification of shed hairs and faecal samples.

  8. How extreme are extremes?

    Science.gov (United States)

    Cucchi, Marco; Petitta, Marcello; Calmanti, Sandro

    2016-04-01

    High temperatures have an impact on the energy balance of any living organism and on the operational capabilities of critical infrastructures. Heat-wave indicators have been mainly developed with the aim of capturing the potential impacts on specific sectors (agriculture, health, wildfires, transport, power generation and distribution). However, the ability to capture the occurrence of extreme temperature events is an essential property of a multi-hazard extreme climate indicator. Aim of this study is to develop a standardized heat-wave indicator, that can be combined with other indices in order to describe multiple hazards in a single indicator. The proposed approach can be used in order to have a quantified indicator of the strenght of a certain extreme. As a matter of fact, extremes are usually distributed in exponential or exponential-exponential functions and it is difficult to quickly asses how strong was an extreme events considering only its magnitude. The proposed approach simplify the quantitative and qualitative communication of extreme magnitude

  9. Formulation optimization of arecoline patches.

    Science.gov (United States)

    Wu, Pao-Chu; Tsai, Pi-Ju; Lin, Shin-Chen; Huang, Yaw-Bin

    2014-01-01

    The response surface methodology (RSM) including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS), Eudragit RL 100 (ERL) and polyvinylpyrrolidone K30 (PVP), plasticizers (PEG 400), and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline.

  10. Formulation Optimization of Arecoline Patches

    Directory of Open Access Journals (Sweden)

    Pao-Chu Wu

    2014-01-01

    Full Text Available The response surface methodology (RSM including polynomial equations has been used to design an optimal patch formulation with appropriate adhesion and flux. The patch formulations were composed of different polymers, including Eudragit RS 100 (ERS, Eudragit RL 100 (ERL and polyvinylpyrrolidone K30 (PVP, plasticizers (PEG 400, and drug. In addition, using terpenes as enhancers could increase the flux of the drug. Menthol showed the highest enhancement effect on the flux of arecoline.

  11. Current patch test results with the European baseline series and extensions to it from the 'European Surveillance System on Contact Allergy' network, 2007-2008

    NARCIS (Netherlands)

    Uter, Wolfgang; Aberer, Werner; Armario-Hita, José Carlos; Fernandez-Vozmediano, José M; Ayala, Fabio; Balato, Anna; Bauer, Andrea; Ballmer-Weber, Barbara; Beliauskiene, Aiste; Fortina, Anna Belloni; Bircher, Andreas; Brasch, Jochen; Chowdhury, Mahbub M U; Coenraads, Pieter-Jan; Schuttelaar, Marie-Louise; Cooper, Sue; Czarnecka-Operacz, Magda; Zmudzinska, Maria; Elsner, Peter; English, John S C; Frosch, Peter J; Fuchs, Thomas; García-Gavín, Juan; Fernández-Redondo, Virginia; Gawkrodger, David J; Giménez-Arnau, Ana; Green, Cathy M; Horne, Helen L; Johansen, Jeanne Duus; Jolanki, Riitta; Pesonen, Maria; King, Clodagh M; Krêcisz, Beata; Chomiczewska, Dorota; Kiec-Swierczynska, Marta; Larese, Francesca; Mahler, Vera; Ormerod, Anthony D; Peserico, Andrea; Rantanen, Tapio; Rustemeyer, Thomas; Sánchez-Pérez, Javier; Sansom, Jane E; Silvestre, Juan Fco; Simon, Dagmar; Spiewak, Radoslaw; Statham, Barry N; Stone, Natalie; Wilkinson, Mark; Schnuch, Axel

    2012-01-01

    BACKGROUND: The pattern of contact sensitization to the supposedly most important allergens assembled in the baseline series differs between countries, presumably at least partly because of exposure differences. Objectives. To describe the prevalence of contact sensitization to allergens tested in c

  12. Current patch test results with the European baseline series and extensions to it from the 'European Surveillance System on Contact Allergy' network, 2007-2008

    DEFF Research Database (Denmark)

    Uter, Wolfgang; Aberer, Werner; Armario-Hita, José Carlos

    2012-01-01

    The pattern of contact sensitization to the supposedly most important allergens assembled in the baseline series differs between countries, presumably at least partly because of exposure differences. Objectives. To describe the prevalence of contact sensitization to allergens tested in consecutiv...... patients in the years 2007 and 2008, and to discuss possible differences....

  13. Test of visuospatial construction: Validity evidence in extremely low birth weight and late preterm children at early school age.

    Science.gov (United States)

    Rider, G Nicole; Weiss, Brandi A; McDermott, Adam T; Hopp, Crista A; Baron, Ida Sue

    2016-01-01

    The Test of Visuospatial Construction (TVSC), a measure of visuoconstruction that does not rely on upper extremity motor response or written production, was administered to extremely low birth weight (ELBW), late preterm (LPT), and term participants at preschool (n = 355) and kindergarten (n = 265) ages. TVSC showed statistically significant weak-to-moderate positive correlations (age 3: r = .118-.303; age 6: r = .138-.348) with Developmental VMI, Differential Ability Scales-II Copying, Matrices, and Pattern Construction subtests, Baron-Hopkins Board Test, and the Purdue Pegboard. One-way ANOVA indicated ELBW performed worse than Term (p = .044) on visuospatial construction at age 3 with a small-to-medium effect size (d = -0.43). No other statistically significant differences were found at age 3 on the TVSC (ELBW/LPT: p = .608, d = -0.17; LPT/Term: p = .116, d = -0.31). At age 6, ELBW participants performed worse than LPT participants (p = .027) and Term participants (p = .012); LPT participants did not differ from Term participants. Small effect sizes at age 3 (ELBW < LPT, d = -0.17; ELBW < Term, d = -0.43) were notably larger at age 6 (ELBW < LPT, d = -0.42; ELBW < Term, d = -0.53). Important practical differences showing LPT participants performed below Term participants (d = -0.31) at age 3 were no longer evident at age 6 (d = -0.097). These findings provide preliminary evidence of TVSC validity supporting its use to detect neuropsychological impairment and to recommend appropriate interventions in young preterm children.

  14. Bilaterally Weighted Patches for Disparity Map Computation

    Directory of Open Access Journals (Sweden)

    Laura Fernández Julià

    2015-03-01

    Full Text Available Visual correspondence is the key for 3D reconstruction in binocular stereovision. Local methods perform block-matching to compute the disparity, or apparent motion, of pixels between images. The simplest approach computes the distance of patches, usually square windows, and assumes that all pixels in the patch have the same disparity. A prominent artifact of the method is the "foreground fattening effet" near depth discontinuities. In order to find a more appropriate support, Yoon and Kweon introduced the use of weights based on color similarity and spatial distance, analogous to those used in the bilateral filter. This paper presents the theory of this method and the implementation we have developed. Moreover, some variants are discussed and improvements are used in the final implementation. Several examples and tests are presented and the parameters and performance of the method are analyzed.

  15. Metamaterial Embedded Wearable Rectangular Microstrip Patch Antenna

    Directory of Open Access Journals (Sweden)

    J. G. Joshi

    2012-01-01

    Full Text Available This paper presents an indigenous low-cost metamaterial embedded wearable rectangular microstrip patch antenna using polyester substrate for IEEE 802.11a WLAN applications. The proposed antenna resonates at 5.10 GHz with a bandwidth and gain of 97 MHz and 4.92 dBi, respectively. The electrical size of this antenna is 0.254λ×0.5λ. The slots are cut in rectangular patch to reduce the bending effect. This leads to mismatch the impedance at WLAN frequency band; hence, a metamaterial square SRR is embedded inside the slot. A prototype antenna has been fabricated and tested, and the measured results are presented in this paper. The simulated and measured results of the proposed antenna are found to be in good agreement. The bending effect on the performance of this antenna is experimentally verified.

  16. Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes

    DEFF Research Database (Denmark)

    Frosch, P J; Pilz, B; Andersen, Klaus Ejner

    1995-01-01

    ), citronellol (1) and amyl salicylate (1)). The remaining 41 fragrances were negative. 28 irritant or doubtful reactions on day 3/4 were observed to a total of 19 FF materials (more than 1 reaction: 5% citronellol (2), 1% amyl salicylate (2), 1% isononyl acetate (3), 0.1% musk xylol (2), 1% citral (2), and 1...... products, 3. soaps) of 400 commercial products on the US market had been determined. In a pilot study on a total of 1069 patients in 11 centres, the appropriate test concentration and vehicle were examined. For most fragrances, 1% and 5% were chosen, and petrolatum proved to be the best vehicle...

  17. Patch testing with fragrances: results of a multicenter study of the European Environmental and Contact Dermatitis Research Group with 48 frequently used constituents of perfumes

    DEFF Research Database (Denmark)

    Frosch, P J; Pilz, B; Andersen, Klaus Ejner

    1995-01-01

    The objective of this study was to determine the frequency of reactivity to a series of commonly used fragrances in dermatological patients. A total of 48 fragrances (FF) were chosen, based on the publication of Fenn in 1989 in which the top 25 constituents of 3 types (1. perfumes, 2. household...... mix (FM) and its 8 constituents. In patients with a positive reaction to any of the 48 FF, a careful history with regard to past or present reactions to perfumed products was taken. A total of 1323 patients were tested in 11 centres. The 8% FM was positive in 89 patients (8.3% of 1072 patients...

  18. TRIMETAZIDINE HYDROCHLORIDE TRANSDERMAL PATCH: FORMULATION AND IN-VITRO EVALUATION

    Directory of Open Access Journals (Sweden)

    Sarfaraz Md

    2012-07-01

    Full Text Available The present study was carried out to formulate and evaluate matrix-type transdermal formulations containing trimetazidine hydrochloride with polymers such as carboxymethyl chitosan and hydroxypropylmethylcellulose (HPMC 5cps by solvent evaporation technique with glycerin, as plasticizer. The prepared patches were tested for their physicochemical characteristics such as thickness, weight variation, drug content uniformity, folding endurance and tensile strength. The partition coefficient study was performed using n-octanol as the organic phase and phosphate buffer pH 7.4 as an aqueous phase and it was found to be 1.01. In-vitro release studies of trimetazidine hydrochloride-loaded patches in phosphate buffer (pH, 7.4 exhibited drug release in the range of 89.40 to 92.10 % in 24 hrs. The parameter flux (J was calculated and it was in the range of 1.325 to 2.898 mg/cm2/hr. Based on optimization studies, patches containing carboxymethyl chitosan patches were chosen as optimized formulation. Skin irritation studies were performed on optimized transdermal patch and were found to be free of irritation. The patches were subjected to short term stability studies and were found stable. FTIR studies revealed no interactions between drug and excipients. Data of in vitro release from optimized patches were fit in to different equations and kinetic models such as zero order, first-order, Higuchi and Korsmeyer-Peppas models to explain release kinetics.

  19. A torus patch approximation approach for point projection on surfaces

    OpenAIRE

    Liu, Xiao-ming; Yang, Lei; Yong, Jun-Hai; Gu, He-Jin; Sun, Jia-Guang

    2009-01-01

    International audience; This paper proposes a second order geometric iteration algorithm for point projection and inversion on parametric surfaces. The iteration starts from an initial projection estimation. In each iteration, we construct a second order osculating torus patch to the parametric surface at the previous projection. Then we project the test point onto the torus patch to compute the next projection and its parameter. This iterative process is terminated when the parameter satisfi...

  20. Taro corms mucilage/HPMC based transdermal patch: an efficient device for delivery of diltiazem hydrochloride.

    Science.gov (United States)

    Sarkar, Gunjan; Saha, Nayan Ranjan; Roy, Indranil; Bhattacharyya, Amartya; Bose, Madhura; Mishra, Roshnara; Rana, Dipak; Bhattacharjee, Debashis; Chattopadhyay, Dipankar

    2014-05-01

    The aim of this work is to examine the effectiveness of mucilage/hydroxypropylmethylcellulose (HPMC) based transdermal patch (matrix type) as a drug delivery device. We have successfully extracted mucilage from Colocasia esculenta (Taro) corms and prepared diltiazem hydrochloride incorporated mucilage/HPMC based transdermal patches using various wt% of mucilage by the solvent evaporation technique. Characterization of both mucilage and transdermal patches has been done by several techniques such as Molisch's test, organoleptic evaluation of mucilage, mechanical, morphological and thermal analysis of transdermal patches. Skin irritation test is studied on hairless Albino rat skin showing that transdermal patches are apparently free of potentially hazardous skin irritation. Fourier transform infrared analysis shows that there is no interaction between drug, mucilage and HPMC while scanning electron microscopy shows the surface morphology of transdermal patches. In vitro drug release time of mucilage-HPMC based transdermal patches is prolonged with increasing mucilage concentration in the formulation.

  1. Anaerobic metabolism at thermal extremes: a metabolomic test of the oxygen limitation hypothesis in an aquatic insect.

    Science.gov (United States)

    Verberk, W C E P; Sommer, U; Davidson, R L; Viant, M R

    2013-10-01

    Thermal limits in ectotherms may arise through a mismatch between supply and demand of oxygen. At higher temperatures, the ability of their cardiac and ventilatory activities to supply oxygen becomes insufficient to meet their elevated oxygen demand. Consequently, higher levels of oxygen in the environment are predicted to enhance tolerance of heat, whereas reductions in oxygen are expected to reduce thermal limits. Here, we extend previous research on thermal limits and oxygen limitation in aquatic insect larvae and directly test the hypothesis of increased anaerobic metabolism and lower energy status at thermal extremes. We quantified metabolite profiles in stonefly nymphs under varying temperatures and oxygen levels. Under normoxia, the concept of oxygen limitation applies to the insects studied. Shifts in the metabolome of heat-stressed stonefly nymphs clearly indicate the onset of anaerobic metabolism (e.g., accumulation of lactate, acetate, and alanine), a perturbation of the tricarboxylic acid cycle (e.g., accumulation of succinate and malate), and a decrease in energy status (e.g., ATP), with corresponding decreases in their ability to survive heat stress. These shifts were more pronounced under hypoxic conditions, and negated by hyperoxia, which also improved heat tolerance. Perturbations of metabolic pathways in response to either heat stress or hypoxia were found to be somewhat similar but not identical. Under hypoxia, energy status was greatly compromised at thermal extremes, but energy shortage and anaerobic metabolism could not be conclusively identified as the sole cause underlying thermal limits under hyperoxia. Metabolomics proved useful for suggesting a range of possible mechanisms to explore in future investigations, such as the involvement of leaking membranes or free radicals. In doing so, metabolomics provided a more complete picture of changes in metabolism under hypoxia and heat stress.

  2. Effects of patch-size on populations of intertidal limpets, Siphonaria spp., in a linear landscape.

    Directory of Open Access Journals (Sweden)

    Victoria J Cole

    Full Text Available Organisms with different life-histories and abilities to disperse often utilise habitat patches in different ways. We investigated the influence of the size of patches of rock (separated by stretches of sand on the density of pulmonate limpets (Siphonaria spp. along 1500 km of the linear landscape of the South African coastline. We compared the influence of patch-size on two congeneric species with different modes of development, S. serrata a direct developer, and S. concinna a planktonic developer. We tested the spatial and temporal consistency of the effects of patch-size by sampling 7 independent regions spanning the distributional range of both species of limpets, and by sampling one region at monthly intervals for 1 year. Within each region or month, 4 small patches (60 m in length were sampled. Across the entire geographic range and throughout the year, there were more of both species of limpets in large patches than in small patches. In most regions, there was greater variability in large patches than small patches. Variability within patches in a single region was similar throughout the year, with greater variability of both species in large than in small patches. We found little influence of the mode of development on the response of limpets to patch-size. Our findings highlight the importance of understanding patterns of distribution of species with respect to habitat heterogeneity in linear landscapes, and contradict the idea that organism mobility at an early ontogenetic stage directly affects habitat use.

  3. Constructing parametric triangular patches with boundary conditions

    Institute of Scientific and Technical Information of China (English)

    Hui Liu; Jun Ma; Fuhua Cheng

    2008-01-01

    The problem of constructing a parametric triangular patch to smoothly connect three surface patches is studied. Usually, these surface patches are defined on different parameter spaces. Therefore, it is necessary to define interpolation conditions, with values from the given surface patches, on the boundary of the triangular patch that can ensure smooth transition between different parameter spaces. In this paper we present a new method to define boundary conditions. Boundary conditions defined by the new method have the same parameter space if the three given surface patches can be converted into the same form through affine transformation. Consequently, any of the classic methods for constructing functional triangular patches can be used directly to construct a parametric triangular patch to connect given surface patches with G continuity. The resulting parametric triangular patch preserves precision of the applied classic method.

  4. Investigation of the effects of mirror therapy on the upper extremity functions of stroke patients using the manual function test.

    Science.gov (United States)

    Kim, Hwanhee; Shim, Jemyung

    2015-01-01

    [Purpose] The purpose of this study was to investigate the effects of mirror therapy on the upper extremity functions of stroke patients. [Subjects] The subjects of this study were 14 hemiplegia patients (8 males, 6 females; 9 infarction, 5 hemorrhage; 8 right hemiplegia, 6 left hemiplegia) who voluntarily consented to participate in the study. [Methods] The Korean version of the manual function test (MFT) was used in this study. The test was performed in the following order: arm movement (4 items), grasp and pinch (2 items), and manipulation (2 items). The experiment was conducted with the subjects sitting in a chair. The mirror was vertically placed in the sagittal plane on the desk. The paretic hand was placed behind the mirror, and the non-paretic hand was placed in front of the mirror so that it was reflected in the mirror. In this position, the subjects completed activities repetitively according to the mirror therapy program over the course of four weeks. [Results] There were significant increases in the grasp-and-pinch score and manipulation score. [Conclusion] In conclusion, the grasp-and-pinch and manipulation functions were improved through mirror therapy.

  5. Failure analysis and surety design of composite patching systems.

    Energy Technology Data Exchange (ETDEWEB)

    Hamoush, Sameer (North Carolina A& T State University, Greensboro, NC)

    2004-08-01

    This work presents an experimental evaluation of patch repair of solid laminated composites. The study was focused on destructive and nondestructive tests of full-scale repaired panels under static tension loading conditions. The testing program consisted of ten panels: three pristine, three damaged, three repaired and one repaired with mismatched fiber orientation patch. The evaluated panels were (300 mm x 675 mm) in size and consisted of 6-ply ((-60 /60/0){sub s}) quasi-isotropic laminates. The destructive tests were performed by North Carolina A&T State University and the nondestructive tests were performed by Iowa State University using Pulse-echo C-scan, Air coupled TTU and Auto-Tap. Sandia National Laboratories validated the NDT tests by implementing NDE field methods. Based on the evaluation performed in this study, it appears that the patch repair is an effective means in retrofitting damaged solid composite laminates.

  6. *NEW* CRITICAL Windows Security patches

    CERN Multimedia

    2003-01-01

    On 3 October and 10 September 2003, Microsoft issued new CRITICAL security patches MS03-040 and MS03-039. They must be URGENTLY applied on ALL WINDOWS systems, which are not centrally managed for security patches. This includes Experiment computers, Home computers and Windows Portable and Desktop systems not running NICE. Details of the security holes and patches are at: MS03-039: http://cern.ch/it-div/news/hotfix-MS03-039.asp http://www.microsoft.com/technet/security/bulletin/MS03-039.asp MS03-040: http://cern.ch/it-div/news/hotfix-MS03-040.asp http://www.microsoft.com/technet/security/bulletin/MS03-040.asp

  7. Patch test results of the European baseline series among patients with occupational contact dermatitis across Europe - analyses of the European Surveillance System on Contact Allergy network, 2002-2010.

    Science.gov (United States)

    Pesonen, Maria; Jolanki, Riitta; Larese Filon, Francesca; Wilkinson, Mark; Kręcisz, Beata; Kieć-Świerczyńska, Marta; Bauer, Andrea; Mahler, Vera; John, Swen M; Schnuch, Axel; Uter, Wolfgang

    2015-03-01

    Occupational contact dermatitis is one of the most common occupational diseases in Europe. In order to develop effective preventive measures, detailed and up-to-date data on the incidence, main causes and professions at risk of occupational contact dermatitis are needed. To describe the pattern of patch test reactivity to allergens in the European baseline series of patients with occupational contact dermatitis in different occupations. We analysed data collected by the European Surveillance System on Contact Allergy (ESSCA) network from 2002 to 2010, from 11 European countries. Allergens in the European baseline series associated with an at least doubled risk of occupational contact dermatitis include: thiuram rubber chemical accelerators, epoxy resin, and the antimicrobials methylchloroisothiazolinone/methylisothiazolinone, methyldibromo glutaronitrile, and formaldehyde. The highest risk of occupational contact dermatitis was found in occupations classified as 'other personal services workers', which includes hairdressers, nursing and other healthcare professionals, precision workers in metal and related materials, and blacksmiths, tool-makers and related trades workers. In the planning and implementation of measures aimed at preventing occupational contact dermatitis, the focus should be on the identified high-risk occupational groups and the most common occupational allergies. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. Automated planar patch-clamp.

    Science.gov (United States)

    Milligan, Carol J; Möller, Clemens

    2013-01-01

    Ion channels are integral membrane proteins that regulate the flow of ions across the plasma membrane and the membranes of intracellular organelles of both excitable and non-excitable cells. Ion channels are vital to a wide variety of biological processes and are prominent components of the nervous system and cardiovascular system, as well as controlling many metabolic functions. Furthermore, ion channels are known to be involved in many disease states and as such have become popular therapeutic targets. For many years now manual patch-clamping has been regarded as one of the best approaches for assaying ion channel function, through direct measurement of ion flow across these membrane proteins. Over the last decade there have been many remarkable breakthroughs in the development of technologies enabling the study of ion channels. One of these breakthroughs is the development of automated planar patch-clamp technology. Automated platforms have demonstrated the ability to generate high-quality data with high throughput capabilities, at great efficiency and reliability. Additional features such as simultaneous intracellular and extracellular perfusion of the cell membrane, current clamp operation, fast compound application, an increasing rate of parallelization, and more recently temperature control have been introduced. Furthermore, in addition to the well-established studies of over-expressed ion channel proteins in cell lines, new generations of planar patch-clamp systems have enabled successful studies of native and primary mammalian cells. This technology is becoming increasingly popular and extensively used both within areas of drug discovery as well as academic research. Many platforms have been developed including NPC-16 Patchliner(®) and SyncroPatch(®) 96 (Nanion Technologies GmbH, Munich), CytoPatch™ (Cytocentrics AG, Rostock), PatchXpress(®) 7000A, IonWorks(®) Quattro and IonWorks Barracuda™, (Molecular Devices, LLC); Dynaflow(®) HT (Cellectricon

  9. Analysis of the Results of Patch Test for 430 Patients with Dermatitis and Eczema%430例皮炎湿疹患者斑贴试验结果分析

    Institute of Scientific and Technical Information of China (English)

    陈海燕; 唐燕笑; 廖小玉

    2014-01-01

    [Objective]To explore the distribution of common allergens in pitch test for 430 patients with dermatitis and eczema.[Methods]A total of 430 patients wit dermatitis and eczema were chosen.Ruimin patch test reagent was used for allergen test.The result of allergens was analyzed.[Results]The most common aller-gens of patients with dermatitis and eczema were cobalt chloride,nickel sulfate,potassium dichromate,Kappa mixtures and aromatic mixture.[Conclusion]At present,heavy metal compound such as cobalt chloride and aromatic organic compound are the main allergens of dermatitis and eczema.%【目的】探讨430例皮炎湿疹患者斑贴试验中常见过敏原的分布情况。【方法】选取皮炎湿疹患者430例,采用“瑞敏牌”斑贴试剂进行过敏原测试,分析其过敏原结果。【结果】皮炎湿疹患者过敏原以氯化钴、硫酸镍、重铬酸钾、卡巴混合物、芳香混合物最为常见。【结论】氯化钴等重金属化合物及芳香族有机化合物是目前主要的皮炎湿疹过敏原。

  10. Patch size and isolation predict plant species density in a naturally fragmented forest.

    Science.gov (United States)

    Munguía-Rosas, Miguel A; Montiel, Salvador

    2014-01-01

    Studies of the effects of patch size and isolation on plant species density have yielded contrasting results. However, much of the available evidence comes from relatively recent anthropogenic forest fragments which have not reached equilibrium between extinction and immigration. This is a critical issue because the theory clearly states that only when equilibrium has been reached can the number of species be accurately predicted by habitat size and isolation. Therefore, species density could be better predicted by patch size and isolation in an ecosystem that has been fragmented for a very long time. We tested whether patch area, isolation and other spatial variables explain variation among forest patches in plant species density in an ecosystem where the forest has been naturally fragmented for long periods of time on a geological scale. Our main predictions were that plant species density will be positively correlated with patch size, and negatively correlated with isolation (distance to the nearest patch, connectivity, and distance to the continuous forest). We surveyed the vascular flora (except lianas and epiphytes) of 19 forest patches using five belt transects (50×4 m each) per patch (area sampled per patch = 0.1 ha). As predicted, plant species density was positively associated (logarithmically) with patch size and negatively associated (linearly) with patch isolation (distance to the nearest patch). Other spatial variables such as patch elevation and perimeter, did not explain among-patch variability in plant species density. The power of patch area and isolation as predictors of plant species density was moderate (together they explain 43% of the variation), however, a larger sample size may improve the explanatory power of these variables. Patch size and isolation may be suitable predictors of long-term plant species density in terrestrial ecosystems that are naturally and anthropogenically fragmented.

  11. Patch size and isolation predict plant species density in a naturally fragmented forest.

    Directory of Open Access Journals (Sweden)

    Miguel A Munguía-Rosas

    Full Text Available Studies of the effects of patch size and isolation on plant species density have yielded contrasting results. However, much of the available evidence comes from relatively recent anthropogenic forest fragments which have not reached equilibrium between extinction and immigration. This is a critical issue because the theory clearly states that only when equilibrium has been reached can the number of species be accurately predicted by habitat size and isolation. Therefore, species density could be better predicted by patch size and isolation in an ecosystem that has been fragmented for a very long time. We tested whether patch area, isolation and other spatial variables explain variation among forest patches in plant species density in an ecosystem where the forest has been naturally fragmented for long periods of time on a geological scale. Our main predictions were that plant species density will be positively correlated with patch size, and negatively correlated with isolation (distance to the nearest patch, connectivity, and distance to the continuous forest. We surveyed the vascular flora (except lianas and epiphytes of 19 forest patches using five belt transects (50×4 m each per patch (area sampled per patch = 0.1 ha. As predicted, plant species density was positively associated (logarithmically with patch size and negatively associated (linearly with patch isolation (distance to the nearest patch. Other spatial variables such as patch elevation and perimeter, did not explain among-patch variability in plant species density. The power of patch area and isolation as predictors of plant species density was moderate (together they explain 43% of the variation, however, a larger sample size may improve the explanatory power of these variables. Patch size and isolation may be suitable predictors of long-term plant species density in terrestrial ecosystems that are naturally and anthropogenically fragmented.

  12. Testing Chern-Simons Modified Gravity with Gravitational-Wave Detections of Extreme-Mass-Ratio Binaries

    CERN Document Server

    Canizares, Priscilla; Sopuerta, Carlos F

    2012-01-01

    [abridged] The detection of gravitational waves from extreme-mass-ratio (EMRI) binaries, comprising a stellar-mass compact object orbiting around a massive black hole, is one of the main targets for low-frequency gravitational-wave detectors in space, like the Laser Interferometer Space Antenna (LISA or eLISA/NGO). The long-duration gravitational-waveforms emitted by such systems encode the structure of the strong field region of the massive black hole, in which the inspiral occurs. The detection and analysis of EMRIs will therefore allow us to study the geometry of massive black holes and determine whether their nature is as predicted by General Relativity and even to test whether General Relativity is the correct theory to describe the dynamics of these systems. To achieve this, EMRI modeling in alternative theories of gravity is required to describe the generation of gravitational waves. In this paper, we explore to what extent EMRI observations with LISA or eLISA/NGO might be able to distinguish between G...

  13. Advanced Genetic Testing Comes to the Pain Clinic to Make a Diagnosis of Paroxysmal Extreme Pain Disorder

    Directory of Open Access Journals (Sweden)

    Ashley Cannon

    2016-01-01

    Full Text Available Objective. To describe the use of an advanced genetic testing technique, whole exome sequencing, to diagnose a patient and their family with a SCN9A channelopathy. Setting. Academic tertiary care center. Design. Case report. Case Report. A 61-year-old female with a history of acute facial pain, chronic pain, fibromyalgia, and constipation was found to have a gain of function SCN9A mutation by whole exome sequencing. This mutation resulted in an SCN9A channelopathy that is most consistent with a diagnosis of paroxysmal extreme pain disorder. In addition to the patient being diagnosed, four siblings have a clinical diagnosis of SCN9A channelopathy as they have consistent symptoms and a sister with a known mutation. For treatment, gabapentin was ineffective and carbamazepine was not tolerated. Nontraditional therapies improved symptoms and constipation resolved with pelvic floor retraining with biofeedback. Conclusion. Patients with a personal and family history of chronic pain may benefit from a referral to Medical Genetics. Pelvic floor retraining with biofeedback should be considered for patients with a SCN9A channelopathy and constipation.

  14. Oxidative effects of extremely low frequency magnetic field and radio frequency radiation on testes tissues of diabetic and healthy rats.

    Science.gov (United States)

    Kuzay, D; Ozer, C; Sirav, B; Canseven, A G; Seyhan, N

    2017-01-01

    With the development of technology, people are increasingly under the exposure of electromagnetic fields. Individuals with chronic diseases such as diabetes are now long-term exposed to Radio Frequency-RF radiation and extremely low frequency (ELF) magnetic fields (MFs). The purpose of this present study is to investigate oxidative effects and antioxidant parameters of ELF MFs and RF radiation on testis tissue in diabetic and healthy rats. Wistar male rats were divided into 10 groups. Intraperitoneal single dose STZ (65 mg/kg) dissolved in citrate buffer (0.1M (pH 4.5)) was injected to diabetes groups. ELF MFs and RF radiation were used as an electromagnetic exposure for 20 min/day, 5 days/week for one month. Testis tissue oxidant malondialdehyde (MDA), and antioxidants glutathione (GSH), and total nitric oxide (NOx) levels were determined. The results of ANOVA and Mann-Whitney tests were compared; p radiation resulted in an increase in testicular tissue MDA and NOX levels (p radiation practices increased the oxidative stress in testis tissue while causing a decrease in antioxidant level which was more distinctive in diabetic rats (Tab. 1, Fig. 3, Ref. 30).

  15. Patch testing with constituents of Compositae mixes

    DEFF Research Database (Denmark)

    Paulsen, Evy; Andersen, Klaus Ejner

    2012-01-01

    to parthenolide or parthenolide-containing extracts, followed by German chamomile, yarrow, and arnica. As German chamomile is a weak sensitizer, the results suggest cross-reactions or reactions to unknown allergens. No one was positive to Roman chamomile. Conclusions. Even though parthenolide seems...

  16. Improved Gain Microstrip Patch Antenna

    Science.gov (United States)

    2015-08-06

    same as one half wavelength, λ, of a design frequency for reception or transmission by the antenna 10. Patch 16 can be joined to a coaxial feed 18. A...expressed in the appended claims. [0024] The foregoing description of the preferred embodiments of the invention has been presented for purposes of

  17. Analysis of the results of patch test in 192 patients with hand eczema%192例手部湿疹患者斑贴试验结果分析

    Institute of Scientific and Technical Information of China (English)

    杨素莲; 朱国兴; 尹颂超; 陈海燕; 张云青; 赖维

    2016-01-01

    目的 探讨手部湿疹患者的常见变应原及其分布特点.方法 于2014年11月至2016年3月,选取手部湿疹患者192例,采用日常生活系列斑贴试剂盒检测患者的接触变应原.结果 192例手部湿疹患者中178例检出1种或1种以上变应原,总阳性率为92.71%;前5位最常见的变应原依次为氯化镍(23.96%)、氯化钴(18.75%)、芳香族混合物(17.19%)、硫酸镍(16.67%)及硫柳汞(13.54%);男性手部湿疹患者中卡巴混合物、萘基混合物、对叔丁基酚醛树脂的阳性率分别为16.88%、14.29%、11.69%,明显高于女性(5.22%、4.35%、3.48%),差异均有统计学意义(x2=7.039、5.963、4.925,均P<0.05).结论 手部湿疹患者常见的变应原为氯化镍、氯化钴、芳香族混合物、硫酸镍和硫柳汞.%Objective To investigate the common allergens in the patients with hand eczema.Methods From November 2014 to March 2016,the patients with hand eczema were tested by the patch test kit of daily life series.Results The results of the patch test of 192 patients with hand eczema were collected.Allergens were detected in 178 (92.71%) cases.The top 5 allergens were nickel chloride (23.96%),cobalt chloride (18.75%),aromatic compounds (17.19%),nickel sulfate (16.67%) and thimerosal (13.54%).The positive rates of kappa mixture,aromatic compounds,tertiary butyl phenolic resin in males were 16.88%,14.29%,11.69%,respectively,which were higher than those (5.22%,4.35%,3.48%) in females.Conclusion Nickel chloride,cobalt chloride,aromatic compounds,nickel sulfate and thimerosal are common allergens in patients with hand eczema.

  18. Local spread of metamitron resistant Chenopodium album L. patches.

    Science.gov (United States)

    Aper, J; De Riek, J; Mechant, E; Bulcke, R; Reheul, D

    2011-01-01

    Molecular markers can provide valuable information on the spread of resistant weed biotypes. In particular, tracing local spread of resistant weed patches will give details on the importance of seed migration with machinery, manure, wind or birds. This study investigated the local spread of metamitron resistant Chenopodium album L. patches in the southwest region of the province West-Flanders (Belgium). During the summer of 2009, leaf and seed samples were harvested in 27 patches, distributed over 10 sugar beet fields and 1 maize field. The fields were grouped in four local clusters. Each cluster corresponded with the farmer who cultivated these fields. A cleaved amplified polymorphic sequence (CAPS) procedure identified the Ser264 to Gly mutation in the D1 protein, endowing resistance to metamitron, a key herbicide applied in sugar beet. The majority of the sampled plants within a patch (97% on average) carried this mutation. Amplified fragment length polymorphism (AFLP) analysis was performed with 4 primer pairs and yielded 270 molecular markers, polymorphic for the whole dataset (303 samples). Analysis of molecular variance revealed that a significant part of the genetic variability was attributed to variation among the four farmer locations (12 %) and variation among Chenopodium album patches within the farmer locations (14%). In addition, Mantel tests revealed a positive correlation between genetic distances (linearised phipt between pairs of patches) and geographic distances (Mantel-coefficient significant at p = 0.002), suggesting isolation-by-distance. In one field, a decreased genetic diversity and strong genetic relationships between all the patches in this field supported the hypothesis of a recent introduction of resistant biotypes. Furthermore, genetic similarity between patches from different fields from the same farmer and from different farmers indicated that seed transport between neighbouring fields is likely to have an important impact on the

  19. Habitat patch size and isolation as predictors of occupancy and number of argyrodine spider kleptoparasites in Nephila webs

    Science.gov (United States)

    Agnarsson, Ingi

    2011-02-01

    How fully a suitable habitat patch is utilized by organisms depends crucially on patch size and isolation. Testing this interplay is made difficult in many systems by the arbitrariness of defining a "habitat patch", measuring its boarders, and relatively low detection probability of the inhabitants. Spider webs as habitat patches for obligate web kleptoparasites are free from these problems. Each individual web is a highly discrete and readily measured habitat patch, and the detection probability of argyrodine spider kleptoparasites is very nearly 1. Hence, spider webs emerge as simple systems for ecological models such as patch occupancy and metapopulation biology. Recently, I showed that the distribution of kleptoparasites among host webs relates both to web (patch) size as well as patch connectivity. Here, I test the relative importance of patch size versus isolation in explaining patch occupancy and abundance of inhabitants. I find that (1) web size is the better predictor of patch occupancy and abundance. (2) Web size is overall positively correlated with abundance, but predicts it most precisely among interconnected webs and not at all among the most isolated webs. Hence, patch occupancy and inhabitant abundance is explained by a rather complex interplay between patch size and isolation.

  20. APE: the Active Phasing Experiment to test new control system and phasing technology for a European Extremely Large Optical Telescope

    Science.gov (United States)

    Gonte, F.; Yaitskova, N.; Derie, F.; Constanza, A.; Brast, R.; Buzzoni, B.; Delabre, B.; Dierickx, P.; Dupuy, C.; Esteves, R.; Frank, C.; Guisard, S.; Karban, R.; Koenig, E.; Kolb, J.; Nylund, M.; Noethe, L.; Surdej, I.; Courteville, A.; Wilhelm, R.; Montoya, L.; Reyes, M.; Esposito, S.; Pinna, E.; Dohlen, K.; Ferrari, M.; Langlois, M.

    2005-08-01

    The future European Extremely Large Telescope will be composed of one or two giant segmented mirrors (up to 100 m of diameter) and of several large monolithic mirrors (up to 8 m in diameter). To limit the aberrations due to misalignments and defective surface quality it is necessary to have a proper active optics system. This active optics system must include a phasing system to limit the degradation of the PSF due to misphasing of the segmented mirrors. We will present the lastest design and development of the Active Phasing Experiment that will be tested in laboratory and on-sky connected to a VLT at Paranal in Chile. It includes an active segmented mirror, a static piston plate to simulate a secondary segmented mirror and of four phasing wavefront sensors to measure the piston, tip and tilt of the segments and the aberrations of the VLT. The four phasing sensors are the Diffraction Image Phase Sensing Instrument developed by Instituto de Astrofisica de Canarias, the Pyramid Phasing Sensor developed by Arcetri Astrophysical Observatory, the Shack-Hartmann Phasing Sensor developed by the European Southern Observatory and the Zernike Unit for Segment phasing developed by Laboratoire d'Astrophysique de Marseille. A reference measurement of the segmented mirror is made by an internal metrology developed by Fogale Nanotech. The control system of Active Phasing Experiment will perform the phasing of the segments, the guiding of the VLT and the active optics of the VLT. These activities are included in the Framework Programme 6 of the European Union.

  1. Evaluation of adhesive properties of patches based on acrylic matrices.

    Science.gov (United States)

    Minghetti, P; Cilurzo, F; Montanari, L

    1999-01-01

    Adhesion is an essential property of the dermal and transdermal therapeutic systems (TS). It is influenced by the composition and the thickness of the matrix and also by the characteristics of the backing layer. Our aim was to evaluate the usefulness of the "thumb tack test," the "tack rolling ball test," and the "peel adhesion 180 degrees test" in the development studies and quality control of TS. These tests were performed on two series of placebo patches in which the backing layer was made of artificial silk (series 1) and polyurethane film (series 2). The patches of both series were prepared using five different mixtures of a hydrophilic adhesive copolymer and a hydrophobic nonadhesive copolymer as matrices. Plastoid E 35 L, a copolymer of dimethylaminoethyl methacrylate and neutral methacrylic esters, was used as the adhesive polymer. Eudragit NE 40 D, a copolymer of ethylacrylate and methylmethacrylate, was used as the nonadhesive copolymer. In the standard procedure for the peel adhesion 180 degrees test, used in the tape industries, the adherent is made of stainless steel. Because the latter has a high surface energy, it was not suitable for the analysis of the patches with a polyurethane backing layer. Therefore, the critical surface tension of five alternative materials (rubber, polysiloxane, polyethylene, nylon, polyvinyl chloride) was evaluated. Polyethylene was selected for the modified peel adhesion 180 degrees test, and better results were obtained in terms of feasibility of the test and ability to discriminate between the different patches prepared.

  2. Destroying a near-extremal Kerr black hole with a charged particle: Can a test magnetic field serve as a cosmic censor?

    CERN Document Server

    Shaymatov, Sanjar; Ahmedov, Bobomurat; Joshi, Pankaj S

    2014-01-01

    We investigate effect of a test magnetic field on the process of destroying near-extremal Kerr black hole with a charged test particle. It has been shown that it would be possible to throw a charged test particle into the near extremal rotating black hole and make it go past the extremality i.e. turn Kerr black hole into the Kerr-Newmann naked singularity. Typically in an astrophysical scenario black holes are believed to be surrounded by a magnetic field. Magnetic field although small, affects motion of charged particles drastically due to the large Lorentz force, as the electromagnetic force is much stronger that the gravity. Thus a test magnetic field can affect the process of destroying black holes and restore the cosmic censorship in the astrophysical context. We show that a test magnetic field would act as a cosmic censor beyond a certain threshold value. We try to gauge the magnitude of the magnetic field by comparing its energy density with that of the change in the curvature induced by the test parti...

  3. Patch stage of mycosis fungoides

    Directory of Open Access Journals (Sweden)

    Mavarkar Laxman

    2001-01-01

    Full Text Available Parapsoriasis is aeon troversial topic. There are many studies regarding the relationship of parapsoriasis to lymphoma but no correlation between histology and clinical appearance. Parapsoriasis satisfies histologic criteria for mycosis fungoides and therefore it should be considered as patch stage of mycosis fungoides. A 30-year-old man presented with scaly skin lesions over the trunk since 4 years. Routine blood and urine investigations were normal. Skin biopsy from the lesion revealed atypical lymphocytes within the epidermis without spongiosis.

  4. Capacitance of circular patch resonator

    Energy Technology Data Exchange (ETDEWEB)

    Miano, G.; Verolino, L. [Dip. di Ingegneria Elettrica, Ist. Nazionale di Fisica Nucleare, Naples (Italy); Panariello, G. [Dip. di Ingegneria Elettronica, Naples (Italy); Vaccaro, V.G. [Ist. Nazionale di Fisica Nucleare, Naples (Italy). Dipt. di Scienze Fisiche

    1995-11-01

    In this paper the capacitance of the circular microstrip patch resonator is computed. It is shown that the electrostatic problem can be formulated as a system of dual integral equations, and the most interesting techniques of solutions of these systems are reviewed. Some useful approximated formulas for the capacitance are derived and plots of the capacitance are finally given in a wide range of dielectric constants.

  5. Foraging decisions, patch use, and seasonality in egrets (Aves: ciconiiformes)

    Science.gov (United States)

    Erwin, R.M.

    1985-01-01

    Feeding snowy (Egretta thula) and great (Casmerodius albus) egrets were observed during 2 breeding seasons in coastal New Jersey and 2 brief winter periods in northeast Florida (USA). A number of tests based on assumptions of foraging models, predictions from foraging theory, and earlier empirical tests concerning time allocation and movement in foraging patches was made. Few of the expectations based on foraging theory and/or assumptions were supported by the empirical evidence. Snowy egrets fed with greater intensity and efficiency during the breeding season (when young were being fed) than during winter. They also showed some tendency to leave patches when their capture rate declined, and they spent more time foraging in patches when other birds were present nearby. Great egrets showed few of these tendencies, although they did leave patches when their intercapture intervals increased. Satiation differences had some influence on feeding rates in snowy egrets, but only at the end of feeding bouts. Some individuals of both species revisited areas in patches that had recently been exploited, and success rates were usually higher after the 2nd visit. Apparently, for predators of active prey, short-term changes in resource availability ('resource depression') may be more important than resource depletion, a common assumption in most optimal foraging theory models.

  6. Testing Chern-Simons modified gravity with gravitational-wave detections of extreme-mass-ratio binaries

    Science.gov (United States)

    Canizares, Priscilla; Gair, Jonathan R.; Sopuerta, Carlos F.

    2012-08-01

    The detection of gravitational waves from extreme-mass-ratio inspirals (EMRI) binaries, comprising a stellar-mass compact object orbiting around a massive black hole, is one of the main targets for low-frequency gravitational-wave detectors in space, like the Laser Interferometer Space Antenna (LISA) or evolved LISA/New Gravitational Observatory (eLISA/NGO). The long-duration gravitational-waveforms emitted by such systems encode the structure of the strong field region of the massive black hole, in which the inspiral occurs. The detection and analysis of EMRIs will therefore allow us to study the geometry of massive black holes and determine whether their nature is as predicted by general relativity and even to test whether general relativity is the correct theory to describe the dynamics of these systems. To achieve this, EMRI modeling in alternative theories of gravity is required to describe the generation of gravitational waves. However, up to now, only a restricted class of theories has been investigated. In this paper, we explore to what extent EMRI observations with a space-based gravitational-wave observatory like LISA or eLISA/NGO might be able to distinguish between general relativity and a particular modification of it, known as dynamical Chern-Simons modified gravity. Our analysis is based on a parameter estimation study which uses approximate gravitational waveforms obtained via a radiative-adiabatic method. In this framework, the trajectory of the stellar object is modeled as a sequence of geodesics in the spacetime of the modified-gravity massive black hole. The evolution between geodesics is determined by flux formulae based on general relativistic post-Newtonian and black hole perturbation theory computations. Once the trajectory of the stellar compact object has been obtained, the waveforms are computed using the standard multipole formulae for gravitational radiation applied to this trajectory. Our analysis is restricted to a five

  7. Palmar herald patch in pityriasis rosea.

    Science.gov (United States)

    Polat, Mualla; Yildirim, Yasemin; Makara, Anil

    2012-08-01

    Pityriasis rosea is an acute self-limited inflammatory disorder of the skin. The initial clinical features of typical cases are the appearance of a herald patch. The herald patch is commonly located on the thigh, upper arm, trunk or neck; rarely the patch may be on the face, scalp or penis. There are no reports of a palmar herald patch in pityriasis rosea. In this article we present a 14-year-old male patient who had a palmar herald patch with truncal lesions of pityriasis rosea. © 2012 The Authors. Australasian Journal of Dermatology © 2012 The Australasian College of Dermatologists.

  8. A nanofibrous electrospun patch to maintain human mesenchymal cell stemness.

    Science.gov (United States)

    Pandolfi, L; Furman, N Toledano; Wang, Xin; Lupo, C; Martinez, J O; Mohamed, M; Taraballi, F; Tasciotti, E

    2017-03-01

    Mesenchymal stem cells (MSCs) have been extensively investigated in regenerative medicine because of their crucial role in tissue healing. For these properties, they are widely tested in clinical trials, usually injected in cell suspension or in combination with tridimensional scaffolds. However, scaffolds can largely affect the fates of MSCs, inducing a progressive loss of functionality overtime. The ideal scaffold must delay MSCs differentiation until paracrine signals from the host induce their change. Herein, we proposed a nanostructured electrospun gelatin patch as an appropriate environment where human MSCs (hMSCs) can adhere, proliferate, and maintain their stemness. This patch exhibited characteristics of a non-linear elastic material and withstood degradation up to 4 weeks. As compared to culture and expansion in 2D, hMSCs on the patch showed a similar degree of proliferation and better maintained their progenitor properties, as assessed by their superior differentiation capacity towards typical mesenchymal lineages (i.e. osteogenic and chondrogenic). Furthermore, immunohistochemical analysis and longitudinal non-invasive imaging of inflammatory response revealed no sign of foreign body reaction for 3 weeks. In summary, our results demonstrated that our biocompatible patch favored the maintenance of undifferentiated hMSCs for up to 21 days and is an ideal candidate for tridimensional delivery of hMSCs. The present work reports a nanostructured patch gelatin-based able to maintain in vitro hMSCs stemness features. Moreover, hMSCs were able to differentiate toward osteo- and chondrogenic lineages once induces by differentiative media, confirming the ability of this patch to support stem cells for a potential in vivo application. These attractive properties together with the low inflammatory response in vivo make this patch a promising platform in regenerative medicine.

  9. Extreme Heat

    Science.gov (United States)

    ... Landslides & Debris Flow Nuclear Blast Nuclear Power Plants Power Outages Pandemic Radiological Dispersion Device Severe Weather Snowstorms & Extreme ... Landslides & Debris Flow Nuclear Blast Nuclear Power Plants Power Outages Pandemic Radiological Dispersion Device Severe Weather Snowstorms & Extreme ...

  10. de Sitter Extremal Surfaces

    CERN Document Server

    Narayan, K

    2015-01-01

    We study extremal surfaces in de Sitter space in the Poincare slicing in the upper patch, anchored on spatial subregions at the future boundary ${\\cal I}^+$, restricted to constant boundary Euclidean time slices (focussing on strip subregions). We find real extremal surfaces of minimal area as the boundaries of past lightcone wedges of the subregions in question: these are null surfaces with vanishing area. We find also complex extremal surfaces as complex extrema of the area functional, and the area is not always real-valued. In $dS_4$ the area is real and has some structural resemblance with entanglement entropy in a dual $CFT_3$. There are parallels with analytic continuation from the Ryu-Takayanagi expressions for holographic entanglement entropy in $AdS$. We also discuss extremal surfaces in the $dS$ black brane and the de Sitter "bluewall" studied previously. The $dS_4$ black brane complex surfaces exhibit a real finite cutoff-independent extensive piece. In the bluewall geometry, there are real surface...

  11. A large-scale deforestation experiment: effects of patch area and isolation on Amazon birds.

    Science.gov (United States)

    Ferraz, Gonçalo; Nichols, James D; Hines, James E; Stouffer, Philip C; Bierregaard, Richard O; Lovejoy, Thomas E

    2007-01-12

    As compared with extensive contiguous areas, small isolated habitat patches lack many species. Some species disappear after isolation; others are rarely found in any small patch, regardless of isolation. We used a 13-year data set of bird captures from a large landscape-manipulation experiment in a Brazilian Amazon forest to model the extinction-colonization dynamics of 55 species and tested basic predictions of island biogeography and metapopulation theory. From our models, we derived two metrics of species vulnerability to changes in isolation and patch area. We found a strong effect of area and a variable effect of isolation on the predicted patch occupancy by birds.

  12. A large-scale deforestation experiment: Effects of patch area and isolation on Amazon birds

    Science.gov (United States)

    Ferraz, G.; Nichols, J.D.; Hines, J.E.; Stouffer, P.C.; Bierregaard, R.O.; Lovejoy, T.E.

    2007-01-01

    As compared with extensive contiguous areas, small isolated habitat patches lack many species. Some species disappear after isolation; others are rarely found in any small patch, regardless of isolation. We used a 13-year data set of bird captures from a large landscape-manipulation experiment in a Brazilian Amazon forest to model the extinction-colonization dynamics of 55 species and tested basic predictions of island biogeography and metapopulation theory. From our models, we derived two metrics of species vulnerability to changes in isolation and patch area. We found a strong effect of area and a variable effect of isolation on the predicted patch occupancy by birds.

  13. Mandelbrot's Extremism

    NARCIS (Netherlands)

    Beirlant, J.; Schoutens, W.; Segers, J.J.J.

    2004-01-01

    In the sixties Mandelbrot already showed that extreme price swings are more likely than some of us think or incorporate in our models.A modern toolbox for analyzing such rare events can be found in the field of extreme value theory.At the core of extreme value theory lies the modelling of maxima

  14. Allergy testing - skin

    Science.gov (United States)

    Patch tests - allergy; Scratch tests - allergy; Skin tests - allergy; RAST test; Allergic rhinitis - allergy testing; Asthma - allergy testing; Eczema - allergy testing; Hayfever - allergy testing; Dermatitis - allergy testing; Allergy testing; ...

  15. STUDIES ON MELOXICAM SOLID DISPERSION INCORPORATED BUCCAL PATCHES

    Directory of Open Access Journals (Sweden)

    Mohammed Jafar

    2011-05-01

    decreased from the patches when the amount of polymer was increased. Meloxicam solid dispersion incorporated buccal patch (MSM2 containing meloxicam solid dispersion (meloxicam 150mg, PVP250mg, PEG6000 175mg and mixture of lactose and MCC(4:14gm equivalent to 7.5mg of meloxicam, 1.5% of carbopol 934p, 1% of HPMC and 50% of polymer weight of propylene glycol in each 1cm2 of the patch showed highest in-vitro drug release i.e. 99.98% in 8hrs The in-vivo release of meloxicam from its solid dispersion incorporated buccal patches was also studied using rabbit model. A good in-vitro in-vivo correlation was observed in MSM2 patch. All solid dispersion incorporated buccal patches showed excellent stability under tested conditions. Finally it may be concluded that buccal patches were better for improvement of release of meloxicam and also to overcome the gastric side effects of drug.

  16. Patched2 modulates tumorigenesis in patched1 heterozygous mice.

    Science.gov (United States)

    Lee, Youngsoo; Miller, Heather L; Russell, Helen R; Boyd, Kelli; Curran, Tom; McKinnon, Peter J

    2006-07-15

    The sonic hedgehog (SHH) receptor Patched 1 (Ptch1) is critical for embryonic development, and its loss is linked to tumorigenesis. Germ line inactivation of one copy of Ptch1 predisposes to basal cell carcinoma and medulloblastoma in mouse and man. In many cases, medulloblastoma arising from perturbations of Ptch1 function leads to a concomitant up-regulation of a highly similar gene, Patched2 (Ptch2). As increased expression of Ptch2 is associated with medulloblastoma and other tumors, we investigated the role of Ptch2 in tumor suppression by generating Ptch2-deficient mice. In striking contrast to Ptch1-/- mice, Ptch2-/- animals were born alive and showed no obvious defects and were not cancer prone. However, loss of Ptch2 markedly affected tumor formation in combination with Ptch1 haploinsufficiency. Ptch1+/-Ptch2-/- and Ptch1+/-Ptch2+/- animals showed a higher incidence of tumors and a broader spectrum of tumor types compared with Ptch1+/- animals. Therefore, Ptch2 modulates tumorigenesis associated with Ptch1 haploinsufficiency.

  17. Non-invasive neurosensory testing used to diagnose and confirm successful surgical management of lower extremity deep distal posterior compartment syndrome

    Directory of Open Access Journals (Sweden)

    Guyton Gregory P

    2009-05-01

    Full Text Available Abstract Background Chronic exertional compartment syndrome (CECS is characterized by elevated pressures within a closed space of an extremity muscular compartment, causing pain and/or disability by impairing the neuromuscular function of the involved compartment. The diagnosis of CECS is primarily made on careful history and physical exam. The gold standard test to confirm the diagnosis of CECS is invasive intra-compartmental pressure measurements. Sensory nerve function is often diminished during symptomatic periods of CECS. Sensory nerve function can be documented with the use of non-painful, non-invasive neurosensory testing. Methods Non-painful neurosensory testing of the myelinated large sensory nerve fibers of the lower extremity were obtained with the Pressure Specified Sensory Device™ in a 25 year old male with history and invasive compartment pressures consistent with CECS both before and after running on a tread mill. After the patient's first operation to release the deep distal posterior compartment, the patient failed to improve. Repeat sensory testing revealed continued change in his function with exercise. He was returned to the operating room where a repeat procedure revealed that the deep posterior compartment was not completely released due to an unusual anatomic variant, and therefore complete release was accomplished. Results The patient's symptoms numbness in the plantar foot and pain in the distal calf improved after this procedure and his repeat sensory testing performed before and after running on the treadmill documented this improvement. Conclusion This case report illustrates the principal that non-invasive neurosensory testing can detect reversible changes in sensory nerve function after a provocative test and may be a helpful non-invasive technique to managing difficult cases of persistent lower extremity symptoms after failed decompressive fasciotomies for CECS. It can easily be performed before and after

  18. Robust Tracking with Discriminative Ranking Middle-level Patches

    Directory of Open Access Journals (Sweden)

    Hong Liu

    2014-04-01

    Full Text Available The appearance model has been shown to be essential for robust visual tracking since it is the basic criterion to locating targets in video sequences. Though existing tracking-by-detection algorithms have shown to be greatly promising, they still suffer from the drift problem, which is caused by updating appearance models. In this paper, we propose a new appearance model composed of ranking middle-level patches to capture more object distinctiveness than traditional tracking-by-detection models. Targets and backgrounds are represented by both low-level bottom-up features and high-level top-down patches, which can compensate each other. Bottom-up features are defined at the pixel level, and each feature gets its discrimination score through selective feature attention mechanism. In top-down feature extraction, rectangular patches are ranked according to their bottom-up discrimination scores, by which all of them are clustered into irregular patches, named ranking middle-level patches. In addition, at the stage of classifier training, the online random forests algorithm is specially refined to reduce drifting problems.Experiments on challenging public datasets and our test videos demonstrate that our approach can effectively prevent the tracker drifting problem and obtain competitive performance in visual tracking.

  19. Omnidirectional Lamb waves by axisymmetrically-configured magnetostrictive patch transducer.

    Science.gov (United States)

    Lee, Joo Kyung; Kim, Hoe Woong; Kim, Yoon Young

    2013-09-01

    This work presents the generation of omnidirectional Lamb waves by a new magnetostrictive patch transducer (MPT) and investigates its generation mechanism. Although MPTs have been widely used for wave transduction in plates and pipes, no investigation reports the generation of omnidirectional Lamb waves in a plate by an MPT. For the generation, we propose an axisymmetrically-configured MPT that installs multiple axisymmetric turns of coil outside of a permanent cylindrical magnet located above the center of a circular magnetostrictive patch. After confirming the omnidirectivity of the proposed MPT experimentally, the mechanism of the Lamb wave generation and its frequency characteristics are investigated. It is also shown that the Lamb wave is most efficiently generated in a test plate when its wavelength is equal to two-thirds of the magnetostrictive patch diameter. If this wavelength¿patch diameter relation holds, the second radial extensional vibration mode of the patch of the proposed MPT is shown to be the mode responsible for generating the Lamb wave in a plate.

  20. Robust Tracking with Discriminative Ranking Middle-Level Patches

    Directory of Open Access Journals (Sweden)

    Hong Liu

    2014-04-01

    Full Text Available The appearance model has been shown to be essential for robust visual tracking since it is the basic criterion to locating targets in video sequences. Though existing tracking-by-detection algorithms have shown to be greatly promising, they still suffer from the drift problem, which is caused by updating appearance models. In this paper, we propose a new appearance model composed of ranking middle-level patches to capture more object distinctiveness than traditional tracking-by-detection models. Targets and backgrounds are represented by both low-level bottom-up features and high-level top-down patches, which can compensate each other. Bottom-up features are defined at the pixel level, and each feature gets its discrimination score through selective feature attention mechanism. In top-down feature extraction, rectangular patches are ranked according to their bottom-up discrimination scores, by which all of them are clustered into irregular patches, named ranking middle-level patches. In addition, at the stage of classifier training, the online random forests algorithm is specially refined to reduce drifting problems. Experiments on challenging public datasets and our test videos demonstrate that our approach can effectively prevent the tracker drifting problem and obtain competitive performance in visual tracking.

  1. Extreme Velocity Wind Sensor

    Science.gov (United States)

    Perotti, Jose; Voska, Ned (Technical Monitor)

    2002-01-01

    This presentation provides an overview of the development of new hurricane wind sensor (Extreme Velocity Wind Sensor) for the Kennedy Space Center (KSC) which is designed to withstand winds of up to three hundred miles an hour. The proposed Extreme Velocity Wind Sensor contains no moveable components that would be exposed to extreme wind conditions. Topics covered include: need for new hurricane wind sensor, conceptual design, software applications, computational fluid dynamic simulations of design concept, preliminary performance tests, and project status.

  2. Analysis of the patch test results of 141 cases of cosmetic contact dermatitis%141例化妆品接触性皮炎患者斑贴试验结果分析

    Institute of Scientific and Technical Information of China (English)

    焦红; 关蕾; 战静; 程树军; 毕英杰; 赖唯; 任美玲; 陈晓清

    2011-01-01

    目的:检测分析化妆品接触性皮炎患者常见的致敏原种类,为其防治提供依据.方法:2009年10月-2011年2月,对临床诊断的141例化妆品接触性皮炎病例采用患者自用可疑化妆品和欧洲标准27种系列抗原进行斑贴测试;对测试数据进行统计学分析和比较.结果:患者对可疑化妆品斑贴阳性率48.22%(68/141),阳性反应化妆品为45.69% (90/197),导致患者阳性率高的化妆品依次是:香体喷雾(80%,44/55),祛斑霜(56%,14/25),水剂产品(38.89%,7/18),清洁用品(31.58%,6/19)和护肤面霜(乳)(25.62%,31/121).141例患者对欧洲标准27种系列抗原中至少1种过敏者123例,总阳性率87.2%;引起阳性率高的过敏源是:重铬酸钾(43.97%)、硫酸镍(43.26%)、氯化钴(36.17%)、对羟基苯甲酸类混合物(23.40%)、香料混合物(20.57%)、甲基二溴戊二腈(16.31%)、4-苯二胺碱基(15.60%)、苯唑卡因(14.90%)、甲醛(14.89%)、5-氯-2-甲基-4-异噻唑啉(13.48%)、芳香混合物Ⅱ(10.64%).结论:化妆品原料中精炼不良带入的重金属、混合防腐剂、混和香料等是化妆品接触性皮炎的可能过敏源.%Objective To detect and analyze the common allergens of cosmetic contact dermatitis, and provide the basis for prevention and treatment of the disease. Methods 141 diagnosed cases of cosmetic contact dermatitis were chosen from the clinical dermatology during October 2009 to February 2011.Patients' suspicious cosmetics and European standard series antigens were used for patch tests. The test data were analyzed by statistical methods and the results was compared with national monitoring results. Results The positive rate of cosmetic patch tests was 48.22%.(68/141). The rate of the cosmetics caused repeated allergies on patients was 45.69%(90/197). And they were: body spray (80%, 44/55), freckle cream (56%, 14/25), liquid products (38.89%, 7/18), cleaning supplies (31.58%, 6/19) and skin care cream

  3. Temporary patching of damaged UF{sub 6} cylinders

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas, A.L. [Martin Marietta Energy Systems, Inc., OH (United States)

    1991-12-31

    Patching techniques based on application of epoxy resins have been developed for temporarily repairing UF{sub 6} cylinders which have sustained relatively minor damage and must be safely emptied. The method is considerably faster and simpler than metallurgical weld repairs. Laboratory tests, detailed operational procedures, and case histories of experience at the Portsmouth Gaseous Diffusion Plant are described.

  4. Mitral valve mechanics following posterior leaflet patch augmentation

    DEFF Research Database (Denmark)

    Rahmani, Azadeh; Rasmussen, Ann Qvist; Hønge, Jesper Langhoff

    2013-01-01

    tendineae emanating from the posterior papillary muscle in a FIMR-simulated valve, following posterior leaflet patch augmentation. Methods: Mitral valves were obtained from 12 pigs (body weight 80 kg). An in vitro test set-up simulating the left ventricle was used to hold the valves. The left ventricular...... pressure was regulated with water to simulate different static pressures during valve closure. A standardized oval pericardial patch (17 × 29 mm) was introduced into the posterior leaflet from mid P2 to the end of the P3 scallop. Dedicated miniature transducers were used to record the forces exerted...... on the valve, patch augmentation may have an adverse long-term influence on mitral valve function and remodeling....

  5. Patch densities determines movement patterns and foraging efficiency of large herbivores

    NARCIS (Netherlands)

    Knegt, de H.J.; Hengeveld, G.M.; Langevelde, van F.; Boer, de W.F.; Kirkman, K.P.

    2007-01-01

    Few experimental studies have tested theoretical predictions regarding the movement strategies of large herbivores and their consequences for foraging efficiency. We therefore analyze how the movement and foraging behavior of goats are related to patch density, with patches being trees and bushes. W

  6. 安徽地区283例慢性过敏性皮肤病斑贴试验结果分析%Patch test results analysis of 283 cases of chronic dermatitis patients in Anhui

    Institute of Scientific and Technical Information of China (English)

    刘蔚; 姚秀华; 张兰芳; 胡白

    2013-01-01

    目的 探讨慢性过敏性皮肤病患者常见的致敏原及其特点,为其防治提供依据.方法 应用"瑞敏牌"斑贴试剂盒检测283例慢性过敏性皮肤病患者,对试验数据进行统计学分析和比较.结果 283例患者中有158例对20种致敏原中的1种或2种以上呈现阳性反应,总阳性率为55.83%.阳性率高的前5位过敏原依次为:硫酸镍(20.14%)、甲醛(14.49%)、氯化钴(13.43%)、Cl+Me-异噻唑(12.01%)、芳香混合物(10.95%)等.皮损位于躯干四肢者对甲醛阳性率最高(21.88%),唇炎对松香阳性率最高(10.64%).性别、年龄间斑贴试验阳性率无明显差异.结论 斑贴试验寻找慢性过敏性疾病致敏原简单可靠;不同部位皮损和不同病种的常见致敏原不同.%Objective To detect and analyze the common allergens and the character of chronic allergic dermatitis,and to provide the basis for prevention and treatment of the disease. Methods 283 diagnosed cases of chronic allergic dermatitis were tested with a standardized patchtesting technique( Rei Min Pai )against contact allergens. The test data were analyzed by statistical methods and the results were compared with national monitoring results. Results 158 cases were allergic to at least one antigen in 20 kinds of standard series antigens. The total positive rate was 55. 83%. The several antigens which caused the top 5 high positive rate were: nickel sulphate (20.14% ),formaldehyde( 14. 49% ),cobalt chloride( 13.43% ),C1 + Me - isothiazole( 12. 01% ),aromatic compounds( 10. 95% ). The most common allergen causing dermatitis of trunk and limbs was formaldehyde( 21. 88% ). The most common allergen causing cheilitis was colophony( 10. 64% ). There was no statistically significant difference between both sexes and also among different age groups. Conclusion Patch test is a reliable and simple method for looking for allergens in chronic allergic dermatitis. There are different allergens in diverse sick parts and also in

  7. Studying a disease with no home - lessons in trial recruitment from the PATCH II study

    Directory of Open Access Journals (Sweden)

    Thomas Kim S

    2010-03-01

    Full Text Available Abstract Background Cellulitis is a very common condition that often recurs. The PATCH II study was designed to explore the possibility of preventing future episodes of cellulitis, with resultant cost savings for the NHS. This was the first trial to be undertaken by the UK Dermatology Clinical Trials Network. As such, it was the first to test a recruitment model that involved many busy clinicians each contributing just a few patients. Methods A double-blind randomised controlled trial comparing prophylactic antibiotics (penicillin V with placebo tablets, for the prevention of repeat episodes of cellulitis of the leg. Primary outcome was time to subsequent recurrence of cellulitis. Results The PATCH II study was closed to recruitment having enrolled 123 participants from a target of 400. Whilst the recruitment period was extended by 12 months, it was not possible to continue beyond this point without additional funds. Many factors contributed to poor recruitment: (i changes in hospital policy and the introduction of community-based intravenous teams resulted in fewer cellulitis patients being admitted to hospital; ii those who were admitted were seen by many different specialties, making it difficult for a network of dermatology clinicians to identify suitable participants; and iii funding for research staff was limited to a trial manager and a trial administrator at the co-ordinating centre. With no dedicated research nurses at the recruiting centres, it was extremely difficult to maintain momentum and interest in the study. Attempts to boost recruitment by providing some financial support for principal investigators to employ local research staff was of limited success. Discussion The model of a network of busy NHS clinicians all recruiting a few patients into large clinical studies requires further testing. It did not work very well for PATCH II, but this was probably because patients were not routinely seen by dermatologists, and recruitment

  8. Atopy patch test (APT in the diagnosis of food allergy in children with atopic dermatitis Teste de contato atópico (TCA no diagnóstico de alergia alimentar em crianças com dermatite atópica

    Directory of Open Access Journals (Sweden)

    Soloni Afra Pires Levy

    2012-10-01

    Full Text Available BACKGROUND: Atopic Dermatitis is a chronic inflammatory skin disease. Food allergens are important in the pathogenesis in 1/3 of the cases. Several mechanisms are involved in the pathogenesis of Atopic Dermatitis. Immediate reactions are identified by both measurement of specific IgE and skin prick test. Atopy Patch Test seems to be relevant in the investigation of patients with suspected delayed-type reactions. OBJECTIVES: To evaluate the standardization of this method concerning allergen concentration, occlusion time and interpretation, and determine the specificity and sensitivity of the Atopy Patch Test according to the skin prick test and specific IgE levels in food allergy diagnosis in children with Atopic Dermatitis. METHODS: Seventy-two children, aged 2-12 years were selected and followed at the allergy clinic of the Hospital São Zacharias. Skin prick test, specific IgE and food Atopy Patch Test (cow's milk, egg, soy and wheat were carried out. Three groups were submitted to the Atopy Patch Test: (1 Atopic Dermatitis with or without Rhinitis and Asthma; (2 Rhinitis and or Asthma without AD; (3 Healthy individuals. RESULTS: In group 1, 40% of the patients presented positive reactions. The longer the exposure time (48h and 72h, the higher the sensitivity. In group 2, the test was more specific than sensitive for all the extracts, with increased sensitivity the longer the time of exposure (72h. In group 3, 8.3% presented positive tests. CONCLUSION: APT evidenced a great diagnostic value in late-phase reactions to food, with high specificity. It showed to be a specific and reliable tool in comparison with the healthy group's results.FUNDAMENTOS: A Dermatite Atópica é uma doença inflamatória crônica da pele. Os alimentos são importantes na patogênese da doença em 1/3 dos casos. Diversos mecanismos estão envolvidos na fisiopatogenia da dermatite Atópica. As reações imediatas são identificadas pela dosagem de IgE específica e

  9. Scale-dependent feedbacks between patch size and plant reproduction in desert grassland

    Science.gov (United States)

    Svejcar, Lauren N.; Bestelmeyer, Brandon T.; Duniway, Michael C.; James, Darren K.

    2015-01-01

    Theoretical models suggest that scale-dependent feedbacks between plant reproductive success and plant patch size govern transitions from highly to sparsely vegetated states in drylands, yet there is scant empirical evidence for these mechanisms. Scale-dependent feedback models suggest that an optimal patch size exists for growth and reproduction of plants and that a threshold patch organization exists below which positive feedbacks between vegetation and resources can break down, leading to critical transitions. We examined the relationship between patch size and plant reproduction using an experiment in a Chihuahuan Desert grassland. We tested the hypothesis that reproductive effort and success of a dominant grass (Bouteloua eriopoda) would vary predictably with patch size. We found that focal plants in medium-sized patches featured higher rates of grass reproductive success than when plants occupied either large patch interiors or small patches. These patterns support the existence of scale-dependent feedbacks in Chihuahuan Desert grasslands and indicate an optimal patch size for reproductive effort and success in B. eriopoda. We discuss the implications of these results for detecting ecological thresholds in desert grasslands.

  10. Compliance and patching and atropine amblyopia treatments.

    Science.gov (United States)

    Wang, Jingyun

    2015-09-01

    In the past 20 years, there has been a great advancement in knowledge pertaining to compliance with amblyopia treatments. The occlusion dose monitor introduced quantitative monitoring methods in patching, which sparked our initial understanding of the dose-response relationship for patching amblyopia treatment. This review focuses on current compliance knowledge and the impact it has on patching and atropine amblyopia treatment. Copyright © 2015 Elsevier Ltd. All rights reserved.

  11. Multi-Mode Broadband Patch Antenna

    Science.gov (United States)

    Romanofsky, Robert R. (Inventor)

    2001-01-01

    A multi-mode broad band patch antenna is provided that allows for the same aperture to be used at independent frequencies such as reception at 19 GHz and transmission at 29 GHz. Furthermore, the multi-mode broadband patch antenna provides a ferroelectric film that allows for tuning capability of the multi-mode broadband patch antenna over a relatively large tuning range. The alternative use of a semiconductor substrate permits reduced control voltages since the semiconductor functions as a counter electrode.

  12. RF MEMS reconfigurable triangular patch antenna.

    Energy Technology Data Exchange (ETDEWEB)

    Christodoulou, Christos George (The University of New Mexico, Albuquerque, NM); Nordquist, Christopher Daniel; Feldner, Lucas Matthew

    2005-07-01

    A Ka-band RF MEMS enabled frequency reconfigurable triangular microstrip patch antenna has been designed for monolithic integration with RF MEMS phase shifters to demonstrate a low-cost monolithic passive electronically scanned array (PESA). This paper introduces our first prototype reconfigurable triangular patch antenna currently in fabrication. The aperture coupled patch antenna is fabricated on a dual-layer quartz/alumina substrate using surface micromachining techniques.

  13. RF MEMS reconfigurable triangular patch antenna.

    Energy Technology Data Exchange (ETDEWEB)

    Nordquist, Christopher Daniel; Christodoulou, Christos George (University of New Mexico, Albuquerque, NM); Feldner, Lucas Matthew

    2005-01-01

    A Ka-band RF MEMS enabled frequency reconfigurable triangular microstrip patch antenna has been designed for monolithic integration with RF MEMS phase shifters to demonstrate a low-cost monolithic passive electronically scanned array (PESA). This paper introduces our first prototype reconfigurable triangular patch antenna currently in fabrication. The aperture coupled patch antenna is fabricated on a dual-layer quartz/alumina substrate using surface micromachining techniques.

  14. Smart thermal patch for adaptive thermotherapy

    KAUST Repository

    Hussain, Muhammad Mustafa

    2015-11-12

    A smart thermal patch for adaptive thermotherapy is provided. In an embodiment, the patch can be a stretchable, non-polymeric, conductive thin film flexible and non-invasive body integrated mobile thermal heater with wireless control capabilities that can be used to provide adaptive thermotherapy. The patch can be geometrically and spatially tunable on various pain locations. Adaptability allows the amount of heating to be tuned based on the temperature of the treated portion.

  15. Patch layout generation by detecting feature networks

    KAUST Repository

    Cao, Yuanhao

    2015-02-01

    The patch layout of 3D surfaces reveals the high-level geometric and topological structures. In this paper, we study the patch layout computation by detecting and enclosing feature loops on surfaces. We present a hybrid framework which combines several key ingredients, including feature detection, feature filtering, feature curve extension, patch subdivision and boundary smoothing. Our framework is able to compute patch layouts through concave features as previous approaches, but also able to generate nice layouts through smoothing regions. We demonstrate the effectiveness of our framework by comparing with the state-of-the-art methods.

  16. Qualification Testing of Engineering Camera and Platinum Resistance Thermometer (PRT) Sensors for Mars Science Laboratory (MSL) Project under Extreme Temperatures to Assess Reliability and to Enhance Mission Assurance

    Science.gov (United States)

    Ramesham, Rajeshuni; Maki, Justin N.; Cucullu, Gordon C.

    2008-01-01

    Package Qualification and Verification (PQV) of advanced electronic packaging and interconnect technologies and various other types of qualification hardware for the Mars Exploration Rover/Mars Science Laboratory flight projects has been performed to enhance the mission assurance. The qualification of hardware (Engineering Camera and Platinum Resistance Thermometer, PRT) under extreme cold temperatures has been performed with reference to various project requirements. The flight-like packages, sensors, and subassemblies have been selected for the study to survive three times (3x) the total number of expected temperature cycles resulting from all environmental and operational exposures occurring over the life of the flight hardware including all relevant manufacturing, ground operations and mission phases. Qualification has been performed by subjecting above flight-like qual hardware to the environmental temperature extremes and assessing any structural failures or degradation in electrical performance due to either overstress or thermal cycle fatigue. Experiments of flight like hardware qualification test results have been described in this paper.

  17. The Psychometric Properties of a Modified Sit-to-Stand Test With Use of the Upper Extremities in Institutionalized Older Adults.

    Science.gov (United States)

    Le Berre, Melanie; Apap, David; Babcock, Jade; Bray, Sarah; Gareau, Esther; Chassé, Kathleen; Lévesque, Nicole; Robbins, Shawn M

    2016-08-01

    Current sit-to-stand protocols do not permit use of upper extremities, limiting the protocols' utility for institutionalized older adults with diminished physical function. The objective of this study was to modify a 30-s sit-to-stand protocol to allow for arm use and to examine test-retest reliability and convergent validity; 54 institutionalized older adult men (age = 91 ± 3 year) performed the 30-s sit-to-stand twice within a span of 3 to 7 days. Results suggest good test-retest reliability (intraclass correlation coefficient = .84) and convergent validity with the Timed Up and Go Test (r = -.62). This modified 30-s sit-to-stand can be used to assess physical function performance in institutionalized older adults and will ensure that individuals with lower physical function capacity can complete the test, thus eliminating the floor effect demonstrated with other sit-to-stand protocols.

  18. Model Test Setup and Program for Experimental Estimation of Surface Loads of the SSG Kvitsøy Pilot Plant from Extreme Wave Conditions

    DEFF Research Database (Denmark)

    Kofoed, Jens Peter; Larsen, Brian Juul

    This report presents the preparations done prior to model tests planned for November 2005 focusing on experimental estimation of the surface loads on the wave energy convert (WEC) Seawave Slot-Cone Generator (SSG) due to extreme wave conditions. SSG is a WEC utilizing wave overtopping in multiple...... the planned pilot plant site is also modeled. The tests will be carried out at Dept. of Civil Engineering, Aalborg University (AAU) in the 3D deep water wave tank.......This report presents the preparations done prior to model tests planned for November 2005 focusing on experimental estimation of the surface loads on the wave energy convert (WEC) Seawave Slot-Cone Generator (SSG) due to extreme wave conditions. SSG is a WEC utilizing wave overtopping in multiple...... reservoirs. In the present SSG setup three reservoirs have been used. Model tests are planned using a model (length scale 1:60) of the SSG prototype at the planned location of a pilot plant at the west coast of the island Kvitsøy near Stavanger, Norway. The properties of the coastal area surrounding...

  19. Earth's polar cap ionization patches lead to ion upflow

    Science.gov (United States)

    Zhang, Q. H.; Zong, Q.; Lockwood, M. M.; Liang, J.; Zhang, B.; Moen, J. I.; Zhang, S.; Zhang, Y.; Ruohoniemi, J. M.; Thomas, E. G.; Liu, R.; Dunlop, M. W.; Yang, H. G.; Hu, H.; Liu, Y.; Lester, M.

    2014-12-01

    The Earth constantly losses matter through ions escaping from the polar ionosphere. This makes the ionosphere as an important source of plasma for the magnetosphere and could modulate atmospheric isotope abundances on geological timescales, depending on what fraction of the upflowing ions subsequently return to the ionosphere and what fraction are ejected into interplanetary space. It has been proposed that the magnetosphere is dynamically modulated by the presence of the ionospheric ions, particularly heavy ions O+, during magnetic substorms and storms. The origin and formation mechanism of ionospheric ion upflow is, however, poorly understood, particularly under disturbed space weather conditions. We report simultaneous direct observations of ion upflow and a patch of ionization at the center of the polar cap region during a geomagnetic storm. Our observations indicate enhanced fluxes of upwelling O+ ions originate from the patch and were accelerated by the enhanced ambipolar electric field. This enhancement is caused by soft electron precipitations. Polar cap patches therefore provide an important source of upwelling ions for accelerations mechanisms at greater altitudes which can eject the ions. These observations give new insight into the processes of ionosphere-magnetosphere coupling and the potential loss of terrestrial water dissociation products into space which, although extremely slow in the case of Earth, may be significant for other planets and moons.

  20. Fast exact nearest patch matching for patch-based image editing and processing.

    Science.gov (United States)

    Xiao, Chunxia; Liu, Meng; Nie, Yongwei; Dong, Zhao

    2011-08-01

    This paper presents an efficient exact nearest patch matching algorithm which can accurately find the most similar patch-pairs between source and target image. Traditional match matching algorithms treat each pixel/patch as an independent sample and build a hierarchical data structure, such as kd-tree, to accelerate nearest patch finding. However, most of these approaches can only find approximate nearest patch and do not explore the sequential overlap between patches. Hence, they are neither accurate in quality nor optimal in speed. By eliminating redundant similarity computation of sequential overlap between patches, our method finds the exact nearest patch in brute-force style but reduces its running time complexity to be linear on the patch size. Furthermore, relying on recent multicore graphics hardware, our method can be further accelerated by at least an order of magnitude (≥10×). This greatly improves performance and ensures that our method can be efficiently applied in an interactive editing framework for moderate-sized image even video. To our knowledge, this approach is the fastest exact nearest patch matching method for high-dimensional patch and also its extra memory requirement is minimal. Comparisons with the popular nearest patch matching methods in the experimental results demonstrate the merits of our algorithm. © 2011 IEEE

  1. Gravity Survey of the Rye Patch KGRA, Rye Patch, Nevada

    Science.gov (United States)

    Mcdonald, M. R.; Gosnold, W. D.

    2011-12-01

    The Rye Patch Known Geothermal Resource Area (KGRA) is located in Pershing County Nevada on the west side of the Humboldt Range and east of the Rye Patch Reservoir approximately 200 km northeast of Reno, Nevada. Previous studies include an earlier gravity survey, 3-D seismic reflection, vertical seismic profiling (VSP) on a single well, 3-D seismic imaging, and a report of the integrated seismic studies. Recently, Presco Energy conducted an aeromagnetic survey and is currently in the process of applying 2-D VSP methods to target exploration and production wells at the site. These studies have indicated that geothermal fluid flow primarily occurs along faults and fractures and that two potential aquifers include a sandstone/siltstone member of the Triassic Natchez Pass Formation and a karst zone that occurs at the interface between Mesozoic limestone and Tertiary volcanics. We hypothesized that addition of a high-resolution gravity survey would better define the locations, trends, lengths, and dip angles of faults and possible solution cavity features. The gravity survey encompassed an area of approximately 78 km2 (30 mi2) within the boundary of the KGRA along with portions of 8 sections directly to the west and 8 sections directly to the east. The survey included 203 stations that were spaced at 400 m intervals. The simple Bouguer anomaly patterns were coincident with elevation, and those patterns remained after terrain corrections were performed. To remove this signal, the data were further processed using wave-length (bandpass) filtering techniques. The results of the filtering and comparison with the recent aeromagnetic survey indicate that the location and trend of major fault systems can be identified using this technique. Dip angles can be inferred by the anomaly contour gradients. By further reductions in the bandpass window, other features such as possible karst solution channels may also be recognizable. Drilling or other geophysical methods such as a

  2. Design and test of an extremely high resolution Timing Counter for the MEG II experiment: preliminary results

    CERN Document Server

    De Gerone, M; Ootani, W; Uchiyama, Y; Nishimura, M; Shirabe, S; Cattaneo, P W; Rossella, M

    2013-01-01

    The design and tests of Timing Counter elements for the upgrade of the MEG experiment, MEG II,is presented. The detector is based on several small plates of scintillator with a Silicon PhotoMultipliers dual-side readout. The optimisation of the single counter elements (SiPMs, scintillators, geometry) is described. Moreover, the results obtained with a first prototype tested at the Beam Test Facility (BTF) of the INFN Laboratori Nazionali di Frascati (LNF) are presented.

  3. Transdermal patches: history, development and pharmacology.

    Science.gov (United States)

    Pastore, Michael N; Kalia, Yogeshvar N; Horstmann, Michael; Roberts, Michael S

    2015-05-01

    Transdermal patches are now widely used as cosmetic, topical and transdermal delivery systems. These patches represent a key outcome from the growth in skin science, technology and expertise developed through trial and error, clinical observation and evidence-based studies that date back to the first existing human records. This review begins with the earliest topical therapies and traces topical delivery to the present-day transdermal patches, describing along the way the initial trials, devices and drug delivery systems that underpin current transdermal patches and their actives. This is followed by consideration of the evolution in the various patch designs and their limitations as well as requirements for actives to be used for transdermal delivery. The properties of and issues associated with the use of currently marketed products, such as variability, safety and regulatory aspects, are then described. The review concludes by examining future prospects for transdermal patches and drug delivery systems, such as the combination of active delivery systems with patches, minimally invasive microneedle patches and cutaneous solutions, including metered-dose systems.

  4. Formulation study of tea tree oil patches.

    Science.gov (United States)

    Minghetti, Paola; Casiraghi, Antonella; Cilurzo, Francesco; Gambaro, Veniero; Montanari, Luisa

    2009-01-01

    The antimicrobial, antifungal and anti-inflammatory properties of tea tree oil (TTO), the essential oil of Melaleuca alternifolia are well documented. In order to optimize its therapeutic activity, TTO patches were designed. The aim of this work was the formulation of monolayer patches containing TTO. Moreover, the performance of oleic acid (OA) as a skin penetration enhancer in patches was evaluated. Terpinen-4-ol (T4OL), the main component of TTO, was the marker used to evaluate TTO skin permeability. The permeation study was performed through human epidermis by using Franz diffusion cells. Patches were prepared by using methacrylic copolymers, Eudragit E100 (EuE100) or Eudragit NE (EuNE), and a silicone resin, BioPSA7-4602 (Bio-PSA). TTO and OA contents were fixed at 10% w/w and 3% w/w, respectively. The patches were prepared by a casting method and characterised in terms of T4OL content and skin permeability. All the selected polymers were suitable as the main component of the patch matrix. Since the main critical issue in the use of TTO is related to its toxicity after absorption, the local administration of TTO can take advantage of the use of patches based on EuE100 because of the high retained amount and the low permeation of T4OL. In this matrix, OA slightly increased the T4OL retained amount, improving the efficacy and safety of TTO patches.

  5. Streamlining of Plant Patches in Streams

    DEFF Research Database (Denmark)

    Sand-Jensen, Kaj; Pedersen, Morten Lauge

    2008-01-01

    area or root area was significantly lower in shallow water . Canopy shape and indices of streamlining did not change significantly with approach velocity (0.02-0.40 m s)1), either because canopy shape is not sensitive to approach velocity or summer velocities were too low to induce such changes. 3......1. Plants in shallow streams often grow in well-defined monospecific patches experiencing a predictable unidirectional flow, though of temporally variable velocity. During maximum patch development in summer we studied: (i) the shape and streamlining of 59 patches of Callitriche cophocarpa, (ii...... averaged 0.25. The canopy and root area of the patches were more elongate and slender in sites with shallow water, where currents accelerate alongside patches and restrict lateral expansion, compared to deeper sites where currents can pass above the canopy. Similarly, the frontal area relative to planform...

  6. Extreme cosmos

    CERN Document Server

    Gaensler, Bryan

    2011-01-01

    The universe is all about extremes. Space has a temperature 270°C below freezing. Stars die in catastrophic supernova explosions a billion times brighter than the Sun. A black hole can generate 10 million trillion volts of electricity. And hypergiants are stars 2 billion kilometres across, larger than the orbit of Jupiter. Extreme Cosmos provides a stunning new view of the way the Universe works, seen through the lens of extremes: the fastest, hottest, heaviest, brightest, oldest, densest and even the loudest. This is an astronomy book that not only offers amazing facts and figures but also re

  7. Patch scales in coastal ecosystems

    Science.gov (United States)

    Broitman, Bernardo R.

    Quantifying the spatial and temporal scales over which ecological processes are coupled to environmental variability is a major challenge for ecologists. Here, I assimilate patterns of oceanographic variability with ecological field studies in an attempt to quantify spatial and temporal scales of coupling. Using coastal time series of chlorophyll-a concentration from remote sensing, the first chapter examines the alongshore extent of coastal regions subject to similar temporal patterns of oceanographic variability in Western North America (WNA) and North-Central Chile (Chile). I found striking interhemispherical differences in the length of coastal sections under similar oceanographic regimes, with the Chile region showing longshore coherency over much smaller spatial scales (˜60 km) than on the coast of WNA (˜140 km). Through a spatial analysis of coastal orientation I suggest that the characteristic length scales may be traced to the geomorphologic character of the ocean margins. The second chapter examines spatial patterns of primary production through long-term means of coastal chlorophyll-a concentration and kelp (Macrocystis pyrifera) cover and explores their relationship with coastal geomorphology and sea surface temperature (SST). Spatial analyses showed a striking match in length scales around 180--250 km. Strong anticorrelations at small spatial lags and positive correlations at longer distances suggest little overlap between patches of kelp and coastal chlorophyll-a. In agreement with findings from the previous chapter, I found that coastal patches could be traced back to spatial patterns of coastal geomorphology. Through SST time series and long-term datasets of larval recruitment in Santa Cruz Island, California, the third chapter examines temporal patterns of oceanographic variability as determinants of ecological patterns. SST time series from sites experiencing low larval recruitment rates were dominated by strong temporal variability. These sites

  8. Combined Approach of Patch-Surfer and PL-PatchSurfer for Protein-Ligand Binding Prediction in CSAR 2013 and 2014.

    Science.gov (United States)

    Zhu, Xiaolei; Shin, Woong-Hee; Kim, Hyungrae; Kihara, Daisuke

    2016-06-27

    The Community Structure-Activity Resource (CSAR) benchmark exercise provides a unique opportunity for researchers to objectively evaluate the performance of protein-ligand docking methods. Patch-Surfer and PL-PatchSurfer, molecular surface-based methods for predicting binding ligands of proteins developed in our group, were tested on both CSAR 2013 and 2014 benchmark exercises in combination with an empirical scoring function-based method, AutoDock, while we only participated in CSAR 2013 using Patch-Surfer. The prediction results for Phase 1 task in CSAR 2013 showed that Patch-Surfer was able to rank all the four designed binding proteins within top ranks, outperforming AutoDock Vina. In Phase 2 of 2013, PL-PatchSurfer correctly selected the correct ligand pose for two target proteins. PL-PatchSurfer performed reasonably well in ranking ligands according to their binding affinity and in selecting near-native ligand poses in 2013 Phase 3 and 2014 Phase 1, respectively, although AutoDock Vina showed better performance. Lastly, in the 2014 Phase 2 exercise, the PL-PatchSurfer scores computed for ligands to target protein pairs correlated well with their pIC50 values, which was better or comparable to results by other participants. Overall, our methods showed fairly good performance in CSAR 2013 and 2014. Unique characteristics of the methods are discussed in comparison with AutoDock.

  9. Image quality assessment based on inter-patch and intra-patch similarity.

    Directory of Open Access Journals (Sweden)

    Fei Zhou

    Full Text Available In this paper, we propose a full-reference (FR image quality assessment (IQA scheme, which evaluates image fidelity from two aspects: the inter-patch similarity and the intra-patch similarity. The scheme is performed in a patch-wise fashion so that a quality map can be obtained. On one hand, we investigate the disparity between one image patch and its adjacent ones. This disparity is visually described by an inter-patch feature, where the hybrid effect of luminance masking and contrast masking is taken into account. The inter-patch similarity is further measured by modifying the normalized correlation coefficient (NCC. On the other hand, we also attach importance to the impact of image contents within one patch on the IQA problem. For the intra-patch feature, we consider image curvature as an important complement of image gradient. According to local image contents, the intra-patch similarity is measured by adaptively comparing image curvature and gradient. Besides, a nonlinear integration of the inter-patch and intra-patch similarity is presented to obtain an overall score of image quality. The experiments conducted on six publicly available image databases show that our scheme achieves better performance in comparison with several state-of-the-art schemes.

  10. Robustness of metacommunities with omnivory to habitat destruction: disentangling patch fragmentation from patch loss.

    Science.gov (United States)

    Liao, Jinbao; Bearup, Daniel; Wang, Yeqiao; Nijs, Ivan; Bonte, Dries; Li, Yuanheng; Brose, Ulrich; Wang, Shaopeng; Blasius, Bernd

    2017-06-01

    Habitat destruction, characterized by patch loss and fragmentation, is a major driving force of species extinction, and understanding its mechanisms has become a central issue in biodiversity conservation. Numerous studies have explored the effect of patch loss on food web dynamics, but ignored the critical role of patch fragmentation. Here we develop an extended patch-dynamic model for a tri-trophic omnivory system with trophic-dependent dispersal in fragmented landscapes. We found that species display different vulnerabilities to both patch loss and fragmentation, depending on their dispersal range and trophic position. The resulting trophic structure varies depending on the degree of habitat loss and fragmentation, due to a tradeoff between bottom-up control on omnivores (dominated by patch loss) and dispersal limitation on intermediate consumers (dominated by patch fragmentation). Overall, we find that omnivory increases system robustness to habitat destruction relative to a simple food chain. © 2017 by the Ecological Society of America.

  11. Evaluation of a mucoadhesive buccal patch for delivery of peptides: in vitro screening of bioadhesion.

    Science.gov (United States)

    Li, C; Bhatt, P P; Johnston, T P

    1998-10-01

    We have assessed the bioadhesive properties of several different mucoadhesive buccal patches. The patches consisted of custom coformulations of silicone polymers and Carbopol 974P. The contact angle of water was measured for each of the test formulations, using an ophthalmic shadow scope. The corresponding work of adhesion between the water and the patches (W1), and between the patches and freshly-excised rabbit buccal mucosa (W2) was then calculated, using a modification of Dupre's equation. The bioadhesive strength between the patches and excised rabbit buccal mucosa was also assessed. The results of the contact-angle measurements indicated that the contact angle decreased with an increase in the amount of Carbopol in the formulation. Additionally, the calculated values of both W1 and W2 increased with an increase in the amount of Carbopol in the buccal-patch formulations. A correlation (r not equal to 0.9808) was found between the measured contact angle and the calculated values for W2. The direct measurement of the force required to separate a buccal patch from excised rabbit buccal mucosa with the INSTRON demonstrated that the adhesive strength increased with an increase in the amount of Carbopol. This preliminary study has shown that the measurement of contact angles alone may provide a useful technique for estimating the work of adhesion, and may serve as a convenient and rapid screening procedure to identify potential mucoadhesive buccal-patch formulations.

  12. A procedure of landscape services assessment based on mosaics of patches and boundaries.

    Science.gov (United States)

    Martín de Agar, Pilar; Ortega, Marta; de Pablo, Carlos L

    2016-09-15

    We develop a procedure for assessing the environmental value of landscape mosaics that simultaneously considers the values of land use patches and the values of the boundaries between them. These boundaries indicate the ecological interactions between the patches. A landscape mosaic is defined as a set of patches and the boundaries between them and corresponds to a spatial pattern of ecological interactions. The procedure is performed in two steps: (i) an environmental assessment of land use patches by means of a function that integrates values based on the goods and services the patches provide, and (ii) an environmental valuation of mosaics using a function that integrates the environmental values of their patches and the types and frequencies of the boundaries between them. This procedure allows us to measure how changes in land uses or in their spatial arrangement cause variations in the environmental value of landscape mosaics and therefore in that of the whole landscape. The procedure was tested in the Sierra Norte of Madrid (central Spain). The results show that the environmental values of the landscape depend not only on the land use patches but also on the values associated with the pattern of the boundaries within the mosaics. The results also highlight the importance of the boundaries between land use patches as determinants of the goods and services provided by the landscape. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Pairwise Operator Learning for Patch Based Single-image Super-resolution.

    Science.gov (United States)

    Tang, Yi; Shao, Ling

    2016-12-14

    Motivated by the fact that image patches could be inherently represented by matrices, single-image super-resolution is treated as a problem of learning regression operators in a matrix space in this paper. The regression operators that map low-resolution image patches to high-resolution image patches are generally defined by left and right multiplication operators. The pairwise operators are respectively used to extract the raw and column information of low-resolution image patches for recovering high-resolution estimations. The patch based regression algorithm possesses three favorable properties. Firstly, the proposed super-resolution algorithm is efficient during both training and testing, because image patches are treated as matrices. Secondly, the data storage requirement of the optimal pairwise operator is far less than most popular single-image super-resolution algorithms because only two small sized matrices need to be stored. Lastly, the super-resolution performance is competitive with most popular single-image super-resolution algorithms because both raw and column information of image patches is considered. Experimental results show the efficiency and effectiveness of the proposed patch-based single-image superresolution algorithm.

  14. Analysis of the evaluation of the Lab chromatic system on the result of nickel sulfate patch test%L��a��b��色度系统评估硫酸镍斑贴试验结果分析

    Institute of Scientific and Technical Information of China (English)

    杨素莲; 尹颂超; 张云青; 叶聪秀; 易金玲; 谢淑霞; 赖维

    2015-01-01

    Objective To understand the effects of the different results of nickel sulfate patch test on the L*a *b *chromatic system. Methods The occlusive human nickel sulfate patch test was in 38 healthy volunteers.The 2.5%nickel sulfate patch test was tapped on the back of the volunteers for 24 hours.Measurements including clinical evaluation and the determination of L*a *b *were made before patch occlusion and 0.5h(D1),24h(D2) after patch removal, respectively. Results In all 38 subjects, 8 cases were judged positive at D1 and (or) D2.There was no significant difference between positive group an negative group in the values of L**b *and a*at D1 and D2. The a*values of positive goup at D1, D2 were 10.64±1.90,13.22±1.92 respectively, which both were higher than the value 7.80±2.49 before patch test (P=0.000). Conclusion In the contact dermatitis model inducing by nickel sulfate, the a*val⁃ue of the L*a *b *chromatic system can reflect erythematic changes after skin inflammation, showing a*value maybe the objective evaluation parameter to evaluate contact dermatitis.%目的:了解硫酸镍斑贴试验不同结果对L��a��b��色度系统变化的影响。方法:对38名健康志愿者进行人体皮肤封闭型硫酸镍斑贴试验。将2.5%硫酸镍斑试器用胶带贴敷在受试者上背部,同时设空白对照,封包24h后揭去斑试物。分别于试验前(D0)、揭去斑试物后0.5h(D1)、24h(D2)对皮肤反应结果进行临床评估及皮肤颜色L��a��b��值测定。结果:38例受试者中8例在D1和(或)D2时临床评估为阳性。镍斑贴试验阴性组、空白对照组受试者D1、D2时皮肤色度L��值、b��值及a��值较D0均无明显变化;斑贴试验阳性组D1、D2时皮肤色度a��值分别为10.64±1.90和13.22±1.92,较D0时皮肤色度a��值7.80±2.49明显升高(P=0.000)。结论:硫酸镍斑贴诱发的接触性皮炎模型中,L��a��b��色度系统a

  15. Group-living herbivores weigh up food availability and dominance status when making patch-joining decisions.

    Directory of Open Access Journals (Sweden)

    Keenan Stears

    Full Text Available Two key factors that influence the foraging behaviour of group-living herbivores are food availability and individual dominance status. Yet, how the combination of these factors influences the patch-joining decisions of individuals foraging within groups has scarcely been explored. To address this, we focused on the patch-joining decisions of group-living domestic goats (Capra hircus. When individuals were tested against the top four ranked goats of the herd, we found that at patches with low food availability they avoided these dominant patch-holders and only joined subordinates (i.e. costs outweighed benefits. However, as the amount of food increased, the avoidance of the top ranked individuals declined. Specifically, goats shifted and joined the patch of an individual one dominance rank higher than the previous dominant patch holder when the initial quantity of food in the new patch was twice that of the lower ranking individual's patch (i.e. benefits outweighed costs. In contrast, when individuals chose between patches held by dominant goats, other than the top four ranked goats, and subordinate individuals, we found that they equally joined the dominant and subordinate patch-holders. This joining was irrespective of the dominance gap, absolute rank of the dominant patch-holder, sex or food availability (i.e. benefits outweighed costs. Ultimately, our results highlight that herbivores weigh up the costs and benefits of both food availability and patch-holder dominance status when making patch-joining decisions. Furthermore, as the initial quantity of food increases, food availability becomes more important than dominance with regard to influencing patch-joining decisions.

  16. Effects of Spatial Patch Arrangement and Scale of Covarying Resources on Growth and Intraspecific Competition of a Clonal Plant.

    Science.gov (United States)

    Wang, Yong-Jian; Shi, Xue-Ping; Meng, Xue-Feng; Wu, Xiao-Jing; Luo, Fang-Li; Yu, Fei-Hai

    2016-01-01

    Spatial heterogeneity in two co-variable resources such as light and water availability is common and can affect the growth of clonal plants. Several studies have tested effects of spatial heterogeneity in the supply of a single resource on competitive interactions of plants, but none has examined those of heterogeneous distribution of two co-variable resources. In a greenhouse experiment, we grew one (without intraspecific competition) or nine isolated ramets (with competition) of a rhizomatous herb Iris japonica under a homogeneous environment and four heterogeneous environments differing in patch arrangement (reciprocal and parallel patchiness of light and soil water) and patch scale (large and small patches of light and water). Intraspecific competition significantly decreased the growth of I. japonica, but at the whole container level there were no significant interaction effects of competition by spatial heterogeneity or significant effect of heterogeneity on competitive intensity. Irrespective of competition, the growth of I. japonica in the high and the low water patches did not differ significantly in the homogeneous treatments, but it was significantly larger in the high than in the low water patches in the heterogeneous treatments with large patches. For the heterogeneous treatments with small patches, the growth of I. japonica was significantly larger in the high than in the low water patches in the presence of competition, but such an effect was not significant in the absence of competition. Furthermore, patch arrangement and patch scale significantly affected competitive intensity at the patch level. Therefore, spatial heterogeneity in light and water supply can alter intraspecific competition at the patch level and such effects depend on patch arrangement and patch scale.

  17. Real-time screening tests for functional alignment of the trunk and lower extremities in adolescent – a systematic review

    DEFF Research Database (Denmark)

    Junge, Tina; Wedderkopp, Niels; Juul-Kristensen, Birgit

    2012-01-01

    mechanisms resulting in ACL injuries (Hewett, 2010). Prevention may therefore depend on identifying these potentially injury risk factors. Screening tools must thus include patterns of typical movements in sport and leisure time activities, consisting of high-load and multi-directional tests, focusing...... of knee alignment, there is a further need to evaluate reliability and validity of real-time functional alignment tests, before the can be used as screening tools for prevention of knee injuries among adolescents. Still the next step in this systematic review is to evaluate the quality and feasibility...

  18. Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study

    Directory of Open Access Journals (Sweden)

    Boyd Benjamin S

    2010-08-01

    Full Text Available Abstract Background Type 2 Diabetes Mellitus (T2DM and diabetic symmetrical polyneuropathy (DSP impact multiple modalities of sensation including light touch, temperature, position sense and vibration perception. No study to date has examined the mechanosensitivity of peripheral nerves during limb movement in this population. The objective was to determine the unique effects T2DM and DSP have on nerve mechanosensitivity in the lower extremity. Methods This cross-sectional study included 43 people with T2DM. Straight leg raise neurodynamic tests were performed with ankle plantar flexion (PF/SLR and dorsiflexion (DF/SLR. Hip flexion range of motion (ROM, lower extremity muscle activity and symptom profile, intensity and location were measured at rest, first onset of symptoms (P1 and maximally tolerated symptoms (P2. Results The addition of ankle dorsiflexion during SLR testing reduced the hip flexion ROM by 4.3° ± 6.5° at P1 and by 5.4° ± 4.9° at P2. Individuals in the T2DM group with signs of severe DSP (n = 9 had no difference in hip flexion ROM between PF/SLR and DF/SLR at P1 (1.4° ± 4.2°; paired t-test p = 0.34 or P2 (0.9° ± 2.5°; paired t-test p = 0.31. Movement induced muscle activity was absent during SLR with the exception of the tibialis anterior during DF/SLR testing. Increases in symptom intensity during SLR testing were similar for both PF/SLR and DF/SLR. The addition of ankle dorsiflexion induced more frequent posterior leg symptoms when taken to P2. Conclusions Consistent with previous recommendations in the literature, P1 is an appropriate test end point for SLR neurodynamic testing in people with T2DM. However, our findings suggest that people with T2DM and severe DSP have limited responses to SLR neurodynamic testing, and thus may be at risk for harm from nerve overstretch and the information gathered will be of limited clinical value.

  19. A new patch antenna with metamaterial cover

    Institute of Scientific and Technical Information of China (English)

    HU Jun; YAN Chun-sheng; LIN Qing-chun

    2006-01-01

    A metamaterial was introduced into the cover of a patch antenna and its band structure was analyzed. The metamaterial cover with correct selection of the working frequency increases by 9.14 dB the patch antenna's directivity. The mechanism of metamaterial cover is completely different from that of a photonic bandgap cover. The mechanism of the metamaterial cover,the number of the cover's layers, and the distance between the layers, were analyzed in detail. The results showed that the metamaterial cover, which works like a lens, could effectively improve the patch antenna's directivity. The physical reasons for the improvement are also given.

  20. Full Scale Test SSP 34m blade, edgewise loading LTT. Extreme load and PoC_InvE Data report

    DEFF Research Database (Denmark)

    Nielsen, Magda; Roczek-Sieradzan, Agnieszka; Jensen, Find Mølholt

    stresses in the adhesive joints. Test results from measurements with the reinforcement have been compared to results without the coupling. The report presents only the relevant results for the 80% Risø load and the results applicable for the investigation of the influence of the invention on the profile...... in edgewise direction (LTT). The blade has been submitted to thorough examination by means of strain gauges, displacement transducers and a 3D optical measuring system. This data report presents results obtained during full scale testing of the blade up to 80% Risø load, where 80% Risø load corresponds to 100......% certification load. These pulls at 80% Risø load were repeated and the results from these pulls were compared. The blade was reinforced according to a Risø DTU invention, where the trailing edge panels are coupled. The coupling is implemented to prevent the out of plane deformations and to reduce peeling...

  1. Real-time screening tests for functional alignment of the trunk and lower extremities in adolescent – a systematic review

    DEFF Research Database (Denmark)

    Junge, Tina; Wedderkopp, N; Juul-Kristensen, B

    2012-01-01

    mechanisms resulting in ACL injuries (Hewett, 2010). Prevention may therefore depend on identifying these potentially injury risk factors. Screening tools must thus include patterns of typical movements in sport and leisure time activities, consisting of high-load and multi-directional tests, focusing...... of knee alignment, there is a further need to evaluate reliability and validity of real-time functional alignment tests, before the can be used as screening tools for prevention of knee injuries among adolescents. Still the next step in this systematic review is to evaluate the quality and feasibility......Introduction The presence of neuromuscular imbalance (Hewett, 2010) or functional malalignment may be part of the increased rate of adolescent knee injuries, specifically the anterior cruciate ligament (ACL). Abnormal lateral trunk and knee abduction moment are possibly linked to the biomechanical...

  2. Should We Stop Looking for a Better Scoring Algorithm for Handling Implicit Association Test Data? Test of the Role of Errors, Extreme Latencies Treatment, Scoring Formula, and Practice Trials on Reliability and Validity.

    Directory of Open Access Journals (Sweden)

    Juliette Richetin

    Full Text Available Since the development of D scores for the Implicit Association Test, few studies have examined whether there is a better scoring method. In this contribution, we tested the effect of four relevant parameters for IAT data that are the treatment of extreme latencies, the error treatment, the method for computing the IAT difference, and the distinction between practice and test critical trials. For some options of these different parameters, we included robust statistic methods that can provide viable alternative metrics to existing scoring algorithms, especially given the specificity of reaction time data. We thus elaborated 420 algorithms that result from the combination of all the different options and test the main effect of the four parameters with robust statistical analyses as well as their interaction with the type of IAT (i.e., with or without built-in penalty included in the IAT procedure. From the results, we can elaborate some recommendations. A treatment of extreme latencies is preferable but only if it consists in replacing rather than eliminating them. Errors contain important information and should not be discarded. The D score seems to be still a good way to compute the difference although the G score could be a good alternative, and finally it seems better to not compute the IAT difference separately for practice and test critical trials. From this recommendation, we propose to improve the traditional D scores with small yet effective modifications.

  3. Assessment of the risk of falling with the use of timed up and go test in the elderly with lower extremity osteoarthritis

    Directory of Open Access Journals (Sweden)

    Zasadzka E

    2015-08-01

    Full Text Available Ewa Zasadzka,1 Adrianna Maria Borowicz,1 Magdalena Roszak,2 Mariola Pawlaczyk1 1Department of Geriatric Medicine and Gerontology, Karol Marcinkowski University of Medical Sciences, 2Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland Background: Falling in the elderly results in a significant number of admissions to hospitals and long-term care facilities, especially among patients with lower extremity osteoarthritis (OA.Objective: The aim of the study was to assess the risk of falling in adults older than 60 years with OA using timed up and go (TUG test.Materials and methods: A total of 187 patients (aged >60 years were enrolled in the study. The assessment included: basic activities of daily living (ADLs, lower extremity strength with the use of the 30-second chair stand test (30 CST, and assessment of the risk of falling (TUG test. Pain intensity was evaluated with the numeric rating scale (NRS.Results: The TUG test results were significantly better in younger OA patients (aged 60–69 years, as compared with their older peers (aged 70–79 years; P<0.01 and the oldest group (aged >80 years; P<0.001. Also, the 30 CST results were significantly higher in younger OA patients (P<0.05. Subjects older than 80 years had a significantly worse ADL score (P<0.05 and P<0.001. Pain complaints were reported significantly more frequently by women than men (P<0.05. A correlation between age and the TUG test score (r=0.412; P<0.0004 as well as between the TUG test and the 30 CST scores (r=0.7368; P=0.000 was detected. In the group with the TUG test score of <13.5 seconds, the 30 CST (P<0.0001 and ADL (P<0.003 results were significantly better. A comparison of fallers vs nonfallers revealed that the number of falls was significantly higher in the group of subjects who scored $13.5 when compared to <13.5 (P=0.003. Fallers significantly more often reported pain (P<0.0001, whereas nonfallers had

  4. Assessment of the risk of falling with the use of timed up and go test in the elderly with lower extremity osteoarthritis.

    Science.gov (United States)

    Zasadzka, Ewa; Borowicz, Adrianna Maria; Roszak, Magdalena; Pawlaczyk, Mariola

    2015-01-01

    Falling in the elderly results in a significant number of admissions to hospitals and long-term care facilities, especially among patients with lower extremity osteoarthritis (OA). The aim of the study was to assess the risk of falling in adults older than 60 years with OA using timed up and go (TUG) test. A total of 187 patients (aged >60 years) were enrolled in the study. The assessment included: basic activities of daily living (ADLs), lower extremity strength with the use of the 30-second chair stand test (30 CST), and assessment of the risk of falling (TUG test). Pain intensity was evaluated with the numeric rating scale (NRS). The TUG test results were significantly better in younger OA patients (aged 60-69 years), as compared with their older peers (aged 70-79 years; P80 years; P<0.001). Also, the 30 CST results were significantly higher in younger OA patients (P<0.05). Subjects older than 80 years had a significantly worse ADL score (P<0.05 and P<0.001). Pain complaints were reported significantly more frequently by women than men (P<0.05). A correlation between age and the TUG test score (r=0.412; P<0.0004) as well as between the TUG test and the 30 CST scores (r=0.7368; P=0.000) was detected. In the group with the TUG test score of <13.5 seconds, the 30 CST (P<0.0001) and ADL (P<0.003) results were significantly better. A comparison of fallers vs nonfallers revealed that the number of falls was significantly higher in the group of subjects who scored ≥13.5 when compared to <13.5 (P=0.003). Fallers significantly more often reported pain (P<0.0001), whereas nonfallers had significantly better 30 CST results (P=0.0003). Elderly population with OA is at an elevated risk of falling, which increases with progressing age, pain, and muscle weakness. It seems prudent to identify individuals at a high risk of falling and to propose an adequate treatment for them.

  5. Can Stem Cell 'Patch' Help Heart Failure?

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_164475.html Can Stem Cell 'Patch' Help Heart Failure? Small improvement seen over ... Scientists report another step in the use of stem cells to help treat people with debilitating heart failure. ...

  6. A Microstripe Slotted Patch Antenna Using Amc

    Directory of Open Access Journals (Sweden)

    Manju Saini,

    2014-04-01

    Full Text Available Microstrip patch antenna offer an attractive solution to compact and ease-low-cost design of modern wireless communication system due to their many advantages as light weight and low volume, low profile, planer configuration which can be easily made conformal to low fabrication cost and capability of obtaining dual and triple frequency operations. A microstrip patch antenna with bandwidth enhancement by means of artificial magnetic conductor (AMC/electromagnetic band-gap structure (EBG is studied in this paper. The three different geometry shapes, the U, E and H are developed from rectangular patch. The antennas studied in this paper are simulated using sonnet software and results compared with the conventional rectangular patch antenna. The results obtained clearly shows that , bandwidth of conventional rectangular microstrip antenna can be enhanced has been studied

  7. Shallow ATRIS Seafloor Images - West Turtle Shoal Patch Reef, Rawa PatchReef, Dustan Rocks Patch Reef, and Thor Patch Reef, Florida, 2011

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — Underwater digital images, single-beam bathymetry, and global-positioning system (GPS) data were collected September 29-30, 2011 around Dustan Rocks Patch Reef, Thor...

  8. U-Slotted Microstrip Patch Antenna

    Directory of Open Access Journals (Sweden)

    Yogesh Bhomia

    2013-05-01

    Full Text Available A new U–slotted microstrip antenna is proposed. A patch antenna is a narrowband, wide-beam antenna These antennas are low profile, conformal to planar and non-planar surface, simple and inexpensive to manufacture using modern printed circuit technology, mechanically robust when mounted on rigid surface, compatible with MMIC designs and when the particular shape and mode are selected they are very versatile in terms of resonant frequency, polarization, field pattern and impedance. Microstrip antenna consist of a very thin metallic strip (patch placed a small fraction of a wavelength above a ground plane. The patch is generally made of conducting material such as copper or gold and can take any possible shape. This paper presents a design of U - slotted microstrip patch antenna and experimentally studied on IE3D software. This design is achieved by cutting U shape in a patch. With U - slotted shapes patch antenna is designed on a FR4 substrate of thickness 1.524 mm and relative permittivity of 4.4 and mounted above the ground plane at a height of 6 mm. Bandwidth as high as 39% are achieved with stable pattern characteristics, such as gain and cross polarization, within its bandwidth. Impedance bandwidth, antenna gain and return loss are observed for the proposed antenna. Details of the measured and simulated results are presented and discussed

  9. Miniaturized disk bend test-a new technique for monitoring the changes of mechanical properties of structural materials operating in extreme conditions

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Method of Miniaturized Disk Bend Test (MDBT) originally designed for the tests of irradiated materials is a convenient technique for monitoring the degradation of mechanical properties of structural materials operating in extreme conditions. A small size of specimens (disks with 3 mm in diameter and 0.1-0.3 mm in thickness) as well as possibility to use the standard equipments for tension and/or pressure tests allow minimizing the financial charge for application of this method in practice and enable to keep up in the real time with (watch on) the changes of materials mechanical properties induced by the effect of unfavorable environment. Wide application of MDBT or other methods for miniaturized specimen tests does possible to inspect on the fly the changes of strength and ductility of the materials, and, of the expense of it, to prevent an alert conditions caused by the materials degradation, for instance, catastrophic embrittlement.In the paper, methodical aspects of MDBT technique application for estimation of structural materials mechanical properties have been considered. By the example of own results and literature data, the possibilities of MDBT method are demonstrated as well as the correlation of obtained from this technique parameters with the standard mechanical properties such as strength, yield stress and ductility of metals.

  10. Short-term monocular patching boosts the patched eye’s response in visual cortex

    Science.gov (United States)

    Zhou, Jiawei; Baker, Daniel H.; Simard, Mathieu; Saint-Amour, Dave; Hess, Robert F.

    2015-01-01

    Abstract Purpose: Several recent studies have demonstrated that following short-term monocular deprivation in normal adults, the patched eye, rather than the unpatched eye, becomes stronger in subsequent binocular viewing. However, little is known about the site and nature of the underlying processes. In this study, we examine the underlying mechanisms by measuring steady-state visual evoked potentials (SSVEPs) as an index of the neural contrast response in early visual areas. Methods: The experiment consisted of three consecutive stages: a pre-patching EEG recording (14 minutes), a monocular patching stage (2.5 hours) and a post-patching EEG recording (14 minutes; started immediately after the removal of the patch). During the patching stage, a diffuser (transmits light but not pattern) was placed in front of one randomly selected eye. During the EEG recording stage, contrast response functions for each eye were measured. Results: The neural responses from the patched eye increased after the removal of the patch, whilst the responses from the unpatched eye remained the same. Such phenomena occurred under both monocular and dichoptic viewing conditions. Conclusions: We interpret this eye dominance plasticity in adult human visual cortex as homeostatic intrinsic plasticity regulated by an increase of contrast-gain in the patched eye. PMID:26410580

  11. The effects of patch shape and connectivity on nest site selection and reproductive success of the Indigo Bunting.

    Energy Technology Data Exchange (ETDEWEB)

    Weldon, Aimee Jean

    2004-07-01

    Description – Ph.D Dissertation. North Carolina State University. Raleigh, North Carolina. 135 pp. Abatract - Habitat fragmentation and its associated effects have been blamed for the recent population declines of many Neotropical migratory bird species. Increased predation and parasitism resulting from edge-related effects have been implicated for poor nesting success in many studies, mostly of forest interior species. However, little attention has been devoted to disturbance-dependent birds. In this study, I examine how patch shape and connectivity in fragmented landscapes affects the reproductive success of disturbance-dependent bird species, specifically the Indigo Bunting (Passerina cyanea). I conducted my study in a landscape-scale experimental system of similar-area habitat patches that differed in connectivity and in shape. Shapes differed between edgy and rectangular forms, where edgy patches contained 50% more edge than rectangular patches. I tested whether edgy patches function as ecological traps for species with strong edge preferences, by leading them to select dangerous habitats. Indigo Buntings preferentially selected edgy patches over rectangular patches, but experienced significantly lower reproductive success in edgy patches early in the season. Although predation pressure intensified in rectangular patches late in the season, seasonal fecundity was still significantly lower in edgy patches, providing the first empirical evidence that edges can function as ecological traps for Indigo Buntings. A second objective of my study was to evaluate the efficacy of conservation corridors for disturbance-dependent bird species. Conservation corridors have become a popular strategy to preserve biodiversity and promote gene flow in fragmented landscapes, but corridors may also have negative consequences. I tested the hypothesis that corridors can increase nest predation risk in connected patches relative to unconnected patches. Nest predation rates

  12. Effects of an emergent vegetation patch on channel reach bathymetry and stability during repeated unsteady flows

    Science.gov (United States)

    Waters, Kevin A.; Crowe Curran, Joanna

    2016-11-01

    While research into the interaction between in-channel vegetation, flow, and bed sediment has increased in recent years, there is still a need to understand how unsteady flows affect these processes, particularly in terms of channel bed adjustments. In this study, flume experiments tested two flood hydrograph sizes run over sand/gravel and sand/silt beds to evaluate reach scale impacts of a midchannel vegetation patch of variable stem density on channel bathymetry and stability. Alternating flood hydrographs with periods of low, steady flow created flow sequences reflective of an extended unsteady flow regime, thereby simulating time scales consisting of multiple flood events. Digital elevation models provided detailed measurements of channel change following each flood event to enable analysis over each unsteady flow sequence. The vegetation patch created characteristic channel bathymetries dependent on sediment mixture and patch density that in all cases resulted in a more variable bed structure than channels without a patch. Reach scale stability, quantified based on net volumetric bed change, only occurred with a sparse patch in the low flood sequence, corresponding with little variation in surface composition and structure. In most other cases, scour measured at the patch prevented stability at the reach scale, especially in the finer substrate. Overall, findings show that a channel may only adjust to a stable bathymetry upon addition of a midchannel vegetation patch within a limited range of flow regimes and patch stem densities, and that for the experimental conditions tested here, in-stream patches generally did not enhance reach scale bed stability.

  13. Nicotine patches improve mood and response speed in a lexical decision task.

    Science.gov (United States)

    Gentry, M V; Hammersley, J J; Hale, C R; Nuwer, P K; Meliska, C J

    2000-01-01

    The effects of smoking a cigarette or wearing a transdermal nicotine patch on mood and lexical decision-making were tested in eight smokers. Each participant was tested after 4 hours of smoking abstinence, under 4 conditions: placebo (very low nicotine) cigarette, nicotine cigarette, placebo patch, and nicotine patch. Relative to placebo, wearing the nicotine patch reduced Profile of Mood States (POMS) Total Mood Disturbance and Fatigue/Inertia scores, while increasing the speed of some types of lexical decisions. Smoking a nicotine cigarette did not affect reaction times, but unexpectedly decreased the accuracy of Word/ Nonword lexical decisions. Thus, transdermal nicotine may improve mood and facilitate longterm memory search and/or attentional processes in nicotine-deprived smokers.

  14. [The significance of the results of crash-tests with the use of the models of the pedestrians' lower extremities for the prevention of the traffic road accidents].

    Science.gov (United States)

    Smirenin, S A; Fetisov, V A; Grigoryan, V G; Gusarov, A A; Kucheryavets, Yu O

    The disabling injuries inflicted during road traffic accidents (RTA) create a serious challenge for the public health services and are at the same time a major socio-economic problem in the majority of the countries throughout the world. The injuries to the lower extremities of the pedestrians make up the largest fraction of the total number of the non-lethal RTA injuries. Most of them are responsible for the considerable deterioration of the quality of life for the participants in the accidents during the subsequent period. The objective of the present study was to summarize the currently available results of experimental testing of the biomechanical models of the pedestrians' lower extremities in the framework of the program for the prevention of the road traffic accidents as proposed by the World Health Organization (WHO, 2004). The European Enhanced Safety Vehicle Committee (EEVC) has developed a series of crash-tests with the use of the models of the pedestrians' lower extremities simulating the vehicle bumper-pedestrian impact. The models are intended for the assessment of the risk of the tibia fractures and the injuries to the knee joint ligaments. The experts of EEVC proposed the biomechanical criteria for the acceleration of the knee and talocrural parts of the lower limbs as well as for the shear displacement of the knee and knee-bending angle. The engineering solution of this problem is based on numerous innovation proposals being implemented in the machine-building industry with the purpose of reducing the stiffness of structural elements of the bumper and other front components of a modern vehicle designed to protect the pedestrians from severe injuries that can be inflicted in the road traffic accidents. The activities of the public health authorities (in the first place, bureaus of forensic medical expertise and analogous facilities) have a direct bearing on the solution of the problem of control of road traffic injuries because they are possessed of

  15. Preparation and evaluation of cosmetic patches containing lactic and glycolic acids

    Directory of Open Access Journals (Sweden)

    Mahdavi H

    2006-01-01

    Full Text Available Background: Alpha-hydroxy acids such as glycolic acid (GA and lactic acid (LA, are used in cosmetic patches. The important fact in cosmetic patches is its suitable adhesion and peel properties. Aim: The objective of this study was to prepare LA- and GA-containing cosmetic patches and evaluate in-vitro/in-vivo correlation of adhesion properties. Methods: Pressure-sensitive adhesives with different concentrations of GA and LA were cast on a polyethylene terephthalate film. The patches were evaluated for peel adhesive strength. On the basis of in vitro adhesion properties the patches were selected for wear performance tests and skin irritation potential. Results: The adhesion properties (adhesion to steel plate and skin and cohesive strength tests indicated the substantial influence of GA and LA concentrations. Based on in vitro adhesion studies the patches containing 3% (w/w GA were selected for in vivo studies. In vivo studies show that a formulation containing 3% GA displays good adhesion on the skin, but it leaves little residues on the skin. Skin Irritation studies on healthy human volunteers showed negligible erythema at the site of application after 48h. Conclusion: The noninvasive patch test model was found useful for detecting irritant skin reactions to the cosmetic patch containing GA. Our results demonstrated a strong correlation between the adhesion to steel plate and adhesion to skin. But a weak correlation between the degree of adhesive residue on the skin in in vitro and in vivo tests was observed for the formulation containing 3% (w/w GA.

  16. Fracture analysis of cracked metallic plate repaired with adhesive bonding composite patch

    Institute of Scientific and Technical Information of China (English)

    Su Weiguo; Mu Zhitao

    2014-01-01

    Fatigue crack growth test of cracked metallic plate repaired with adhesive bonding composite patch was conducted to study the fracture behavior of crack patching. The failure mode was that crack grows along with adhesive debonding. The crack length and debonding area were measured at different numbers of cycles. The nonlinear three-dimensional(3D)finite element(FE)model considering adhesive debonding and crack growth simultaneously was developed. The experimental and analytical results were in good agreement with each other.

  17. No effects of power line frequency extremely low frequency electromagnetic field exposure on selected neurobehavior tests of workers inspecting transformers and distribution line stations versus controls.

    Science.gov (United States)

    Li, Li; Xiong, De-fu; Liu, Jia-wen; Li, Zi-xin; Zeng, Guang-cheng; Li, Hua-liang

    2014-03-01

    We aimed to evaluate the interference of 50 Hz extremely low frequency electromagnetic field (ELF-EMF) occupational exposure on the neurobehavior tests of workers performing tour-inspection close to transformers and distribution power lines. Occupational short-term "spot" measurements were carried out. 310 inspection workers and 300 logistics staff were selected as exposure and control. The neurobehavior tests were performed through computer-based neurobehavior evaluation system, including mental arithmetic, curve coincide, simple visual reaction time, visual retention, auditory digit span and pursuit aiming. In 500 kV areas electric field intensity at 71.98% of total measured 590 spots were above 5 kV/m (national occupational standard), while in 220 kV areas electric field intensity at 15.69% of total 701 spots were above 5 kV/m. Magnetic field flux density at all the spots was below 1,000 μT (ICNIRP occupational standard). The neurobehavior score changes showed no statistical significance. Results of neurobehavior tests among different age, seniority groups showed no significant changes. Neurobehavior changes caused by daily repeated ELF-EMF exposure were not observed in the current study.

  18. Individual colour patches as multicomponent signals.

    Science.gov (United States)

    Grether, Gregory F; Kolluru, Gita R; Nersissian, Karen

    2004-08-01

    Colour patches are complex traits, the components of which may evolve independently through a variety of mechanisms. Although usually treated as simple, two-dimensional characters and classified as either structural or pigmentary, in reality colour patches are complicated, three-dimensional structures that often contain multiple pigment types and structural features. The basic dermal chromatophore unit of fishes, reptiles and amphibians consists of three contiguous cell layers. Xanthophores and erythrophores in the outermost layer contain carotenoid and pteridine pigments that absorb short-wave light; iridophores in the middle layer contain crystalline platelets that reflect light back through the xanthophores; and melanophores in the basal layer contain melanins that absorb light across the spectrum. Changes in any one component of a chromatophore unit can drastically alter the reflectance spectrum produced, and for any given adaptive outcome (e.g. an increase in visibility), there may be multiple biochemical or cellular routes that evolution could take, allowing for divergent responses by different populations or species to similar selection regimes. All of the mechanisms of signal evolution that previously have been applied to single ornaments (including whole colour patches) could potentially be applied to the individual components of colour patches. To reach a complete understanding of colour patch evolution, however, it may be necessary to take an explicitly multi-trait approach. Here, we review multiple trait evolution theory and the basic mechanisms of colour production in fishes, reptiles and amphibians, and use a combination of computer simulations and empirical examples to show how multiple trait evolution theory can be applied to the components of single colour patches. This integrative perspective on animal colouration opens up a host of new questions and hypotheses. We offer specific, testable functional hypotheses for the most common pigmentary

  19. Influence of anatomic location of lidocaine patch 5% on effectiveness and tolerability for postherpetic neuralgia

    Directory of Open Access Journals (Sweden)

    Nalamachu S

    2013-06-01

    Full Text Available Srinivas Nalamachu,1 Matthew Wieman,2 Leah Bednarek,2 Surya Chitra21International Clinical Research Institute, Overland Park, KS, 2Endo Pharmaceuticals Inc, Malvern, PA, USAPurpose: Lidocaine patch 5% is recommended as a first-line therapy for postherpetic neuralgia pain in neuropathic pain guidelines. Postherpetic neuralgia can occur anywhere on the body but often follows acute herpes zoster occurring in trigeminal and brachial plexus dermatomes. An analysis was conducted to determine whether the anatomic location of lidocaine patch 5% is associated with variations in effectiveness or tolerability in patients with postherpetic neuralgia.Methods: This was a post hoc analysis by anatomic site of patch placement (head [including neck], trunk [chest, abdomen, back, hips], and extremities [arm, leg] of a 4-week, multicenter, open-label study that enrolled patients with persistent pain following herpes zoster infection. Effectiveness was measured by Brief Pain Inventory (BPI average pain intensity (0 [no pain] to 10 [worst imaginable pain] and the BPI subscale for pain relief (0% [no relief] to 100% [complete relief]. Tolerability was assessed on the basis of patient-reported adverse events.Results: Of 332 enrolled patients (59.6% women [n = 198]; 92.5% white [n = 307]; mean [standard deviation] age, 71.2 [13.9] years, those (n = 203 who applied lidocaine patch 5% to a single anatomic site only and had baseline and postbaseline pain score data were analyzed (trunk, n = 130; head, n = 41; extremities, n = 32. The frequency of adverse events differed significantly by anatomic location, with significantly more adverse events reported with patch placement on the head versus the extremities (P = 0.006 or trunk (P = 0.02. BPI average pain improved significantly from baseline in each of the three anatomic areas (mean score decrease, 1.50–2.04; P ≤ 0.002, with no significant difference in effectiveness by patch location.Conclusion: Lidocaine 5% patch was

  20. 丁丙诺啡透皮贴剂在释放度测定中桨碟法与转筒法的差异%Difference between methods of cylinder and paddle over disk used in the release test of buprenorphine transdermal patches

    Institute of Scientific and Technical Information of China (English)

    陈华; 毛睿; 李永庆; 南楠

    2011-01-01

    Objective : To compare the difference between the methods of cylinder and paddle over disk used in the release test of transdermal drug deliver system. Method:The cylinder and paddle over disk method were used respectively to test buprenorphine transdermal patches with the release media of 900 mL of 0. 9% sodium chloride solution. Agilent column which packed TC - C18 as solid phase (250 mm ×4. 6 mm,5 μm) and the mixture of acetonitrile and 0. 05 mol · L-1 potassium dihydrogen phosphate solution( 1: 1. 3) as mobile phase were adoptd. The flow rate was 1.0 mL · min-1. The column temperature was kept at 30 ℃ and the detective wave length was 220 nm.Result : The linear correlation of buprenorphine was observed from the concentrations of 0. 4 - 24 μg · mL-1 ( r =0. 9999) . The recovery of buprenorphine was 102. 1% . There were not difference between the methods of cylinder and paddle over disk used in the release test of transdermal drug deliver system in testing 20 mg of buprenorphine transdermal patches , while there existed difference in testing 5 mg and 10 mg of buprenorphine transdermal patches.Conclusion : There will be error when testing large area patch with paddle over disk method.%目的:对透皮贴剂释放度测定中转筒法装置与中国药典桨碟法装置进行比较.方法:分别使用转筒法装置与中国药典桨碟法装置对丁丙诺啡透皮贴剂的释放曲线进行测定,释放介质为0.9%的氯化钠溶液900 mL;以TC-C18为固定相的Agilent色谱柱(250mmx4.6 mm,5μm),0.05 mol·L-1的磷酸二氢钾溶液与乙腈的混合溶液(1.3:1)为流动相,流速为1.0 mL·min-1,柱温为30℃,检测波长为220 nm.结果:丁丙诺啡在0.4~24μg·mL-1范围内线性关系良好(r=0.9999),回收率为102.1%.对于20 mg规格的透皮贴剂采用不同方法所得的丁丙诺啡释放曲线不存在差异,而对于5 mg规格和10 mg规格则存在差异.结论:中国药典桨碟法装置在测量透皮贴剂的释放度时不

  1. The effect of direct interspecific competition on patch exploitation strategies in parasitoid wasps.

    Science.gov (United States)

    Mohamad, Rihab; Wajnberg, Eric; Monge, Jean-Paul; Goubault, Marlène

    2015-01-01

    The presence of competitors may affect the pay-off of individuals' foraging strategies. They should therefore modify their resource exploitation decisions accordingly. In such a direct competition situation, theory predicts that individuals should stay longer on a resource patch than when foraging alone. However, models predicting patch residence time focus on intraspecific competition without agonistic interactions. Here, we investigate the patch use strategies of females of two parasitoid species, Eupelmus vuilleti and Dinarmus basalis, attacking the same host, Callosobruchus maculatus, knowing that D. basalis is more aggressive and can exclude E. vuilleti during pairwise contests for single hosts. Our results showed that time allocation and oviposition strategies differed in relation to the species and type of competition (i.e., presence/absence of competitor, simultaneous/sequential female introduction or resident/intruder female). Eupelmus vuilleti females tended to wait in the patch surroundings for D. basalis females' departure to return and exploit hosts parasitized by the opponent (after destruction of her eggs). In contrast, D. basalis females tended to self-superparasitize and stay motionless near the hosts. After detecting an E. vuilleti female entering the patch, they attacked and chased her permanently from the patch. Females of both species spent less time in the patch when faced with a competitor than when alone. This study is the first to test the influence of direct interspecific competition and arrival order on patch exploitation strategies in parasitoid species, and highlights the necessity to include agonistic behaviors in theoretical models predicting optimal patch residence time in competitive situations.

  2. Deformation of vortex patches by boundaries

    CERN Document Server

    Crosby, A; Morrison, P J

    2013-01-01

    The deformation of two-dimensional vortex patches in the vicinity of fluid boundaries is investigated. The presence of a boundary causes an initially circular patch of uniform vorticity to deform. Sufficiently far away from the boundary, the deformed shape is well approximated by an ellipse. This leading order elliptical deformation is investigated via the elliptic moment model of Melander, Zabusky & Styczek [M. V. Melander, N. J. Zabusky & A. S. Styczek, J. Fluid. Mech., 167, 95 (1986)]. When the boundary is straight, the centre of the elliptic patch remains at a constant distance from the boundary, and the motion is integrable. Furthermore, since the straining flow acting on the patch is constant in time, the problem is that of an elliptic vortex patch in constant strain, which was analysed by Kida [S. Kida, J. Phys. Soc. Japan, 50, 3517 (1981)]. For more complicated boundary shapes, such as a square corner, the motion is no longer integrable. Instead, there is an adiabatic invariant for the motion....

  3. Measles vaccination using a microneedle patch.

    Science.gov (United States)

    Edens, Chris; Collins, Marcus L; Ayers, Jessica; Rota, Paul A; Prausnitz, Mark R

    2013-07-25

    Measles vaccination programs would benefit from delivery methods that decrease cost, simplify logistics, and increase safety. Conventional subcutaneous injection is limited by the need for skilled healthcare professionals to reconstitute and administer injections, and by the need for safe needle handling and disposal to reduce the risk of disease transmission through needle re-use and needlestick injury. Microneedles are micron-scale, solid needles coated with a dry formulation of vaccine that dissolves in the skin within minutes after patch application. By avoiding the use of hypodermic needles, vaccination using a microneedle patch could be carried out by minimally trained personnel with reduced risk of blood-borne disease transmission. The goal of this study was to evaluate measles vaccination using a microneedle patch to address some of the limitations of subcutaneous injection. Viability of vaccine virus dried onto a microneedle patch was stabilized by incorporation of the sugar, trehalose, and loss of viral titer was less than 1 log10(TCID50) after storage for at least 30 days at room temperature. Microneedle patches were then used to immunize cotton rats with the Edmonston-Zagreb measles vaccine strain. Vaccination using microneedles at doses equaling the standard human dose or one-fifth the human dose generated neutralizing antibody levels equivalent to those of a subcutaneous immunization at the same dose. These results show that measles vaccine can be stabilized on microneedles and that vaccine efficiently reconstitutes in vivo to generate a neutralizing antibody response equivalent to that generated by subcutaneous injection.

  4. Characterizing the morphology of protein binding patches.

    Science.gov (United States)

    Malod-Dognin, Noël; Bansal, Achin; Cazals, Frédéric

    2012-12-01

    Let the patch of a partner in a protein complex be the collection of atoms accounting for the interaction. To improve our understanding of the structure-function relationship, we present a patch model decoupling the topological and geometric properties. While the geometry is classically encoded by the atomic positions, the topology is recorded in a graph encoding the relative position of concentric shells partitioning the interface atoms. The topological-geometric duality provides the basis of a generic dynamic programming-based algorithm comparing patches at the shell level, which may favor topological or geometric features. On the biological side, we address four questions, using 249 cocrystallized heterodimers organized in biological families. First, we dissect the morphology of binding patches and show that Nature enjoyed the topological and geometric degrees of freedom independently while retaining a finite set of qualitatively distinct topological signatures. Second, we argue that our shell-based comparison is effective to perform atomic-level comparisons and show that topological similarity is a less stringent than geometric similarity. We also use the topological versus geometric duality to exhibit topo-rigid patches, whose topology (but not geometry) remains stable upon docking. Third, we use our comparison algorithms to infer specificity-related information amidst a database of complexes. Finally, we exhibit a descriptor outperforming its contenders to predict the binding affinities of the affinity benchmark. The softwares developed with this article are availablefrom http://team.inria.fr/abs/vorpatch_compatch/.

  5. Microneedle patches for vaccination in developing countries.

    Science.gov (United States)

    Arya, Jaya; Prausnitz, Mark R

    2016-10-28

    Millions of people die of infectious diseases each year, mostly in developing countries, which could largely be prevented by the use of vaccines. While immunization rates have risen since the introduction of the Expanded Program on Immunization (EPI), there remain major challenges to more effective vaccination in developing countries. As a possible solution, microneedle patches containing an array of micron-sized needles on an adhesive backing have been developed to be used for vaccine delivery to the skin. These microneedle patches can be easily and painlessly applied by pressing against the skin and, in some designs, do not leave behind sharps waste. The patches are single-dose, do not require reconstitution, are easy to administer, have reduced size to simplify storage, transportation and waste disposal, and offer the possibility of improved vaccine immunogenicity, dose sparing and thermostability. This review summarizes vaccination challenges in developing countries and discusses advantages that microneedle patches offer for vaccination to address these challenges. We conclude that microneedle patches offer a powerful new technology that can enable more effective vaccination in developing countries. Copyright © 2015. Published by Elsevier B.V.

  6. Surface patterning of nanoparticles with polymer patches

    Science.gov (United States)

    Choueiri, Rachelle M.; Galati, Elizabeth; Thérien-Aubin, Héloïse; Klinkova, Anna; Larin, Egor M.; Querejeta-Fernández, Ana; Han, Lili; Xin, Huolin L.; Gang, Oleg; Zhulina, Ekaterina B.; Rubinstein, Michael; Kumacheva, Eugenia

    2016-10-01

    Patterning of colloidal particles with chemically or topographically distinct surface domains (patches) has attracted intense research interest. Surface-patterned particles act as colloidal analogues of atoms and molecules, serve as model systems in studies of phase transitions in liquid systems, behave as ‘colloidal surfactants’ and function as templates for the synthesis of hybrid particles. The generation of micrometre- and submicrometre-sized patchy colloids is now efficient, but surface patterning of inorganic colloidal nanoparticles with dimensions of the order of tens of nanometres is uncommon. Such nanoparticles exhibit size- and shape-dependent optical, electronic and magnetic properties, and their assemblies show new collective properties. At present, nanoparticle patterning is limited to the generation of two-patch nanoparticles, and nanoparticles with surface ripples or a ‘raspberry’ surface morphology. Here we demonstrate nanoparticle surface patterning, which utilizes thermodynamically driven segregation of polymer ligands from a uniform polymer brush into surface-pinned micelles following a change in solvent quality. Patch formation is reversible but can be permanently preserved using a photocrosslinking step. The methodology offers the ability to control the dimensions of patches, their spatial distribution and the number of patches per nanoparticle, in agreement with a theoretical model. The versatility of the strategy is demonstrated by patterning nanoparticles with different dimensions, shapes and compositions, tethered with various types of polymers and subjected to different external stimuli. These patchy nanocolloids have potential applications in fundamental research, the self-assembly of nanomaterials, diagnostics, sensing and colloidal stabilization.

  7. Dermoscopy of shagreen patch: A first report

    Directory of Open Access Journals (Sweden)

    Shivanand Gundalli

    2015-07-01

    Full Text Available The name is derived from French phrase peau chagrinee which is usually found on lower back, buttock and thigh. The major manifestations of Tuberous sclerosis include skin lesions in more than 95%, mental retardation in approximately 50%, autism, seizures in approximately 85%. The incidence at birth is estimated to be 1 in 5800. We report case of shagreen patch in a 27 year female which is present since birth. However there is no history of seizures or consanginous marriage in our case. Associated features are naevus comedonicus and naevus collagenosis, facial angiofibroma. Shagreen patch are present in mandibular area of face. Although, diagnosis is easy, it can be mistaken for inflammatory verrucous epidermal nevus, plaques of other inflammatory skin conditions. Diagnosis is usually on clinical background. Sometimes biopsy is necessary to confirm the diagnosis. Dermoscopy, a non-invasive, in vivo technique for the microscopic examination of pigmented skin lesions, has the potential to improve the diagnostic accuracy. Dermoscopy of Shagreen patch showed reddish-brown strands with white dots giving a cobblestone appearance It can be utilized as a diagnostic aide in the diagnosis of Shagreen patch. Authors evaluated the dermoscopic patterns of Shagreen patch and hence, it is useful in diagnosis.

  8. Randomized, double-blind, placebo-controlled trial using lidocaine patch 5% in traumatic rib fractures.

    Science.gov (United States)

    Ingalls, Nichole K; Horton, Zachary A; Bettendorf, Matthew; Frye, Ira; Rodriguez, Carlos

    2010-02-01

    The lidocaine patch 5% was developed to treat postherpetic neuralgia. Anecdotal experience at our institution suggests the lidocaine patch 5% decreases narcotic usage in patients with traumatic rib fractures. This trial was developed to define the patch's efficacy. Patients with rib fractures admitted to the trauma service at our Level I trauma center were enrolled and randomized in a 1 to 1 double-blind manner to receive a lidocaine patch 5% or placebo patch. Fifty-eight patients who met the inclusion criteria were enrolled from January 2007 to August 2008. Demographic and clinical information were recorded. The primary outcomes variable was total narcotic use, analyzed using the 1-tailed Mann-Whitney test. The secondary outcomes variables included non-narcotic pain medication, average pain score, pulmonary complications, and length of stay. Significance was defined based on a 1-sided test for the primary outcome and 2-sided tests for other comparisons, at p rib fractures, gender, trauma mechanism, preinjury lung disease, smoking history, percent of current smokers, and need for placement of chest tube between the lidocaine patch 5% and placebo groups. There was no difference between the lidocaine patch 5% and placebo groups, respectively, with regard to total IV narcotic usage: median, 0.23 units versus 0.26 units; total oral narcotics: median, 4 units versus 7 units; pain score: 5.6 +/- 0.4 versus 6.0 +/- 0.3 (mean +/- SEM); length of stay: 7.8 +/- 1.1 versus 6.2 +/- 0.7; or percentage of patients with pulmonary complications: 72.7% versus 72.0%. The lidocaine patch 5% does not significantly improve pain control in polytrauma patients with traumatic rib fractures.

  9. Assessment of the effectiveness of nontransdermal energy patches on muscle endurance and power.

    Science.gov (United States)

    Jacobson, Bert H; Smith, Doug B; Stemm, John D; Warren, Aric J; O'Brien, Matt S; Glass, Rob G

    2008-05-01

    Claims of recently developed energy patches suggest that organic nanoscale biomolecular "antennas" produced by L and D-stereoisomers resonate at frequencies in unison with molecules in the cells inducing electron flow to assists in recruiting calcium ions, allowing greater muscle fiber recruitment during muscle contraction. The purpose of the study was to assess the efficacy of energy patches in the performance of selected muscle power and endurance measures. After a 5-minute warm-up and stretch, 41 college varsity football players (age, 20.37 +/- 1.24 years; height, 169.91 +/- 7.44 cm; weight, 109.45 +/- 19.85 kg) were pre-tested on 102-kg maximal bench press repetitions, standing vertical jump, grip strength, peak torque, torque to body weight, total work, average power, and average torque as measured by 50 repetitions of leg extensions at 180 degrees .s. The following week, the players were randomly assigned the experimental or placebo patches. After placement of the patches, the participants again completed a 5-minute warm-up, followed by the identical pre-test protocol. Repeated-measures ANOVAs were used to compare resultant data. No significant group interaction effects were found between experimental and placebo patches for maximal bench press repetitions (p = 0.48), vertical jump distance (p = 0.39), grip strength (p = 0.29), total work (p = 0.26), torque to body weight (p = 0.05), average peak torque (p = 0.08), and average power (p = 0.05). A significant increase occurred in the experimental group for peak torque (p = 0.04). It was concluded that the energy patches significantly improved performance over placebo patches in one of the eight variables tested and registered near significance in two additional variables. However, inconsistency in overall results demands further studies to determine the reliability in improvement of performance in the presence of energy patches.

  10. Improved patch antenna performance by using a metamaterial cover

    Institute of Scientific and Technical Information of China (English)

    ZHU Fang-ming; HU Jun

    2007-01-01

    A new patch antenna system with a metamaterial cover is presented in this paper. The impedance, radiation pattern, and directivity of such an antenna are studied. A performance comparison between the conventional patch antenna and the new metamaterial patch antenna is given. The results show that the directivity of the metamaterial patch antenna is significantly improved. The effect of the metamaterial cover's layer numbers on the radiation pattern of the patch antenna is also studied.

  11. SuperPatchMatch: an Algorithm for Robust Correspondences using Superpixel Patches.

    Science.gov (United States)

    Giraud, Remi; Ta, Vinh-Thong; Bugeau, Aurelie; Coupe, Pierrik; Papadakis, Nicolas

    2017-05-29

    Superpixels have become very popular in many computer vision applications. Nevertheless, they remain underexploited since the superpixel decomposition may produce irregular and non stable segmentation results due to the dependency to the image content. In this paper, we first introduce a novel structure, a superpixel-based patch, called SuperPatch. The proposed structure, based on superpixel neighborhood, leads to a robust descriptor since spatial information is naturally included. The generalization of the PatchMatch method to SuperPatches, named SuperPatchMatch, is introduced. Finally, we propose a framework to perform fast segmentation and labeling from an image database, and demonstrate the potential of our approach since we outperform, in terms of computational cost and accuracy, the results of state-of-the-art methods on both face labeling and medical image segmentation.

  12. Adhesive RFID Sensor Patch for Monitoring of Sweat Electrolytes.

    Science.gov (United States)

    Rose, Daniel P; Ratterman, Michael E; Griffin, Daniel K; Hou, Linlin; Kelley-Loughnane, Nancy; Naik, Rajesh R; Hagen, Joshua A; Papautsky, Ian; Heikenfeld, Jason C

    2015-06-01

    Wearable digital health devices are dominantly found in rigid form factors such as bracelets and pucks. An adhesive radio-frequency identification (RFID) sensor bandage (patch) is reported, which can be made completely intimate with human skin, a distinct advantage for chronological monitoring of biomarkers in sweat. In this demonstration, a commercial RFID chip is adapted with minimum components to allow potentiometric sensing of solutes in sweat, and surface temperature, as read by an Android smartphone app with 96% accuracy at 50 mM Na(+) (in vitro tests). All circuitry is solder-reflow integrated on a standard Cu/polyimide flexible-electronic layer including an antenna, but while also allowing electroplating for simple integration of exotic metals for sensing electrodes. Optional paper microfluidics wick sweat from a sweat porous adhesive allowing flow to the sensor, or the sensor can be directly contacted to the skin. The wearability of the patch has been demonstrated for up to seven days, and includes a protective textile which provides a feel and appearance similar to a standard Band-Aid. Applications include hydration monitoring, but the basic capability is extendable to other mM ionic solutes in sweat (Cl(-), K(+), Mg(2+), NH4(+), and Zn(2+)). The design and fabrication of the patch are provided in full detail, as the basic components could be useful in the design of other wearable sensors.

  13. PL-PatchSurfer: A Novel Molecular Local Surface-Based Method for Exploring Protein-Ligand Interactions

    Directory of Open Access Journals (Sweden)

    Bingjie Hu

    2014-08-01

    Full Text Available Structure-based computational methods have been widely used in exploring protein-ligand interactions, including predicting the binding ligands of a given protein based on their structural complementarity. Compared to other protein and ligand representations, the advantages of a surface representation include reduced sensitivity to subtle changes in the pocket and ligand conformation and fast search speed. Here we developed a novel method named PL-PatchSurfer (Protein-Ligand PatchSurfer. PL-PatchSurfer represents the protein binding pocket and the ligand molecular surface as a combination of segmented surface patches. Each patch is characterized by its geometrical shape and the electrostatic potential, which are represented using the 3D Zernike descriptor (3DZD. We first tested PL-PatchSurfer on binding ligand prediction and found it outperformed the pocket-similarity based ligand prediction program. We then optimized the search algorithm of PL-PatchSurfer using the PDBbind dataset. Finally, we explored the utility of applying PL-PatchSurfer to a larger and more diverse dataset and showed that PL-PatchSurfer was able to provide a high early enrichment for most of the targets. To the best of our knowledge, PL-PatchSurfer is the first surface patch-based method that treats ligand complementarity at protein binding sites. We believe that using a surface patch approach to better understand protein-ligand interactions has the potential to significantly enhance the design of new ligands for a wide array of drug-targets.

  14. Vegetation patches increase wind-blown litter accumulation in a semi-arid steppe of northern China

    Science.gov (United States)

    Yan, Yuchun; Xin, Xiaoping; Xu, Xingliang; Wang, Xu; Yan, Ruirui; Murray, Philip J.

    2016-12-01

    Litter decomposition is an important source of soil organic matter and nutrients; however, few studies have explored how vegetation patches affect wind-driven litter mobility and accumulation. In this study, we aimed to test the following hypotheses: (1) vegetation patches can reduce litter removal and facilitate litter accumulation, (2) litter mobility results in the heterogeneous redistribution of carbon and nutrients over the land surface, and (3) litter removal rates differ among different litter types (e.g., leaf and stem). Four vegetation patch types and six litter types were used to investigate the impacts of vegetation patches on litter mobility and accumulation. The results show that compared with almost bare ground patches, patches with vegetation cover had significantly higher litter accumulation, with the shrub patch type having the highest accumulation amount. The rate of litter removal due to wind was highest for the almost bare surface type (P4) and lowest for the shrub patch (P1) and Stipa grandis community (P2) types. There were significant differences in the removal rate among the different litter types. These findings indicate that wind-based litter redistribution among bare, S. grandis-dominated, and shrub-dominated patches is at least partially responsible for increasing the spatial heterogeneity of resources on a landscape scale.

  15. Can we go beyond burned area assessment with fire patch metrics from global remote rensing?

    Science.gov (United States)

    Nogueira Pereira Messias, Joana; Ruffault, Julien; Chuvieco, Emilio; Mouillot, Florent

    2016-04-01

    Fire is a major event influencing global biogeochemical cycles and contribute to the emissions of CO2 and other greenhouse gases to the atmosphere. Global burned area (BA) datasets from remote sensing have provided the fruitful information for quantifying carbon emissions in global biogeochemical models, and for DGVM's benchmarking. Patch level analysis from pixel level information recently emerged as an informative additional feature of the regime as fire size distribution. The aim of this study is to evaluate the ability of global BA products to accurately represent characteristics of fire patches (size, complexity shape and spatial orientation). We selected a site in the Brazilian savannas (Cerrado), one of the most fire prone biome and one of the validation test site for the ESA fire-Cci project. We used the pixel-level burned area detected by Landsat, MCD45A1 and the newly delivered MERIS ESA fire-Cci for the period 2002-2009. A flood-fill algorithm adapted from Archibald and Roy (2009) was used to identify the individual fire patches (patch ID) according to the burned date (BD). For each patch ID, we calculated a panel of patch metrics as area, perimeter and core area, shape complexity (shape index and fractal dimension) and the feature of the ellipse fitted over the spatial distribution of pixels composing the patch (eccentricity and direction of the main axis). Paired fire patches overlapping between each BA products were compared. The correlation between patch metrics were evaluated by linear regression models for each inter-product comparison according to fire size classes. Our results showed significant patch overlaps (>30%) between products for patches with areas larger than 270ha, with more than 90% of patches overlapping between MERIS and MCD45A1. Fire Patch metrics correlations showed R2>0.6 for all comparisons of patch Area and Core Area, with a slope of 0.99 between MERIS and MCD45A1 illustrating the agreement between the two global products. The

  16. Fault-patch stress-transfer efficiency in presence of sub-patch geometric complexity

    KAUST Repository

    Zielke, Olaf

    2015-04-01

    It is well known that faults are not planar surfaces. Instead they exhibit self-similar or self-affine properties that span a wide range of spatial (sub-micrometer to tens-of-kilometer). This geometric fault roughness has a distinct impact on amount and distribution of stresses/strains induced in the medium and on other portions of the fault. However, when numerically simulated (for example in multi-cycle EQ rupture simulations or Coulomb failure stress calculations) this roughness is largely ignored: individual fault patches --the incremental elements that build the fault surface in the respective computer models-- are planar and fault roughness at this and lower spatial scales is not considered. As a result, the fault-patch stress-transfer efficiency may be systematically too large in those numerical simulations with respect to the "actual" efficiency level. Here, we investigate the effect of sub-patch geometric complexity on fault-patch stress-transfer efficiency. For that, we sub-divide a fault patch (e.g., 1x1km) into a large number of sub-patches (e.g., 20x20m) and determine amount of induced stresses at selected positions around that patch for different levels and realizations of fault roughness. For each fault roughness level, we compute mean and standard deviation of the induced stresses, enabling us to compute the coefficient of variation. We normalize those values with stresses from the corresponding single (planar) fault patch, providing scaling factors and their variability for stress transfer efficiency. Given a certain fault roughness that is assumed for a fault, this work provides the means to implement the sub-patch fault roughness into investigations based on fault-patch interaction schemes.

  17. Extreme Programming: Maestro Style

    Science.gov (United States)

    Norris, Jeffrey; Fox, Jason; Rabe, Kenneth; Shu, I-Hsiang; Powell, Mark

    2009-01-01

    "Extreme Programming: Maestro Style" is the name of a computer programming methodology that has evolved as a custom version of a methodology, called extreme programming that has been practiced in the software industry since the late 1990s. The name of this version reflects its origin in the work of the Maestro team at NASA's Jet Propulsion Laboratory that develops software for Mars exploration missions. Extreme programming is oriented toward agile development of software resting on values of simplicity, communication, testing, and aggressiveness. Extreme programming involves use of methods of rapidly building and disseminating institutional knowledge among members of a computer-programming team to give all the members a shared view that matches the view of the customers for whom the software system is to be developed. Extreme programming includes frequent planning by programmers in collaboration with customers, continually examining and rewriting code in striving for the simplest workable software designs, a system metaphor (basically, an abstraction of the system that provides easy-to-remember software-naming conventions and insight into the architecture of the system), programmers working in pairs, adherence to a set of coding standards, collaboration of customers and programmers, frequent verbal communication, frequent releases of software in small increments of development, repeated testing of the developmental software by both programmers and customers, and continuous interaction between the team and the customers. The environment in which the Maestro team works requires the team to quickly adapt to changing needs of its customers. In addition, the team cannot afford to accept unnecessary development risk. Extreme programming enables the Maestro team to remain agile and provide high-quality software and service to its customers. However, several factors in the Maestro environment have made it necessary to modify some of the conventional extreme

  18. Assembling a Network out of Ambiguous Patches

    OpenAIRE

    Yartseva, Lyudmila; Elbert, Jefferson Simoes; Grossglauser, Matthias

    2016-01-01

    Many graph mining and network analysis problems rely on the availability of the full network over a set of nodes. But inferring a full network is sometimes non-trivial if the raw data is in the form of many small {\\em patches} or subgraphs, of the true network, and if there are ambiguities in the identities of nodes or edges in these patches. This may happen because of noise or because of the nature of data; for instance, in social networks, names are typically not unique. \\textit{Graph...

  19. Learning Dictionaries of Discriminative Image Patches

    DEFF Research Database (Denmark)

    Dahl, Anders Lindbjerg; Larsen, Rasmus

    2011-01-01

    Remarkable results have been obtained using image models based on image patches, for example sparse generative models for image inpainting, noise reduction and superresolution, sparse texture segmentation or texton models. In this paper we propose a powerful and yet simple approach for segmentation...... using dictionaries of image patches with associated label data. The approach is based on ideas from sparse generative image models and texton based texture modeling. The intensity and label dictionaries are learned from training images with associated label information of (a subset) of the pixels based...

  20. Generic Patch Inference

    DEFF Research Database (Denmark)

    Andersen, Jesper; Lawall, Julia Laetitia

    2008-01-01

    A key issue in maintaining Linux device drivers is the need to update drivers in response to evolutions in Linux internal libraries. Currently, there is little tool support for performing and documenting such changes. In this paper we present a tool, spfind, that identifies common changes made...... developers can use it to extract an abstract representation of the set of changes that others have made. Our experiments on recent changes in Linux show that the inferred generic patches are more concise than the corresponding patches found in commits to the Linux source tree while being safe with respect...

  1. Evaluation of the box and blocks test, stereognosis and item banks of activity and upper extremity function in youths with brachial plexus birth palsy.

    Science.gov (United States)

    Mulcahey, Mary Jane; Kozin, Scott; Merenda, Lisa; Gaughan, John; Tian, Feng; Gogola, Gloria; James, Michelle A; Ni, Pengsheng

    2012-09-01

    One of the greatest limitations to measuring outcomes in pediatric orthopaedics is the lack of effective instruments. Computer adaptive testing, which uses large item banks, select only items that are relevant to a child's function based on a previous response and filters items that are too easy or too hard or simply not relevant to the child. In this way, computer adaptive testing provides for a meaningful, efficient, and precise method to evaluate patient-reported outcomes. Banks of items that assess activity and upper extremity (UE) function have been developed for children with cerebral palsy and have enabled computer adaptive tests that showed strong reliability, strong validity, and broader content range when compared with traditional instruments. Because of the void in instruments for children with brachial plexus birth palsy (BPBP) and the importance of having an UE and activity scale, we were interested in how well these items worked in this population. Cross-sectional, multicenter study involving 200 children with BPBP was conducted. The box and block test (BBT) and Stereognosis tests were administered and patient reports of UE function and activity were obtained with the cerebral palsy item banks. Differential item functioning (DIF) was examined. Predictive ability of the BBT and stereognosis was evaluated with proportional odds logistic regression model. Spearman correlations coefficients (rs) were calculated to examine correlation between stereognosis and the BBT and between individual stereognosis items and the total stereognosis score. Six of the 86 items showed DIF, indicating that the activity and UE item banks may be useful for computer adaptive tests for children with BPBP. The penny and the button were strongest predictors of impairment level (odds ratio=0.34 to 0.40]. There was a good positive relationship between total stereognosis and BBT scores (rs=0.60). The BBT had a good negative (rs=-0.55) and good positive (rs=0.55) relationship with

  2. Long-lasting patch reactions to gold sodium thiosulfate occurs frequently in healthy volunteers

    DEFF Research Database (Denmark)

    Andersen, Klaus E; Jensen, Charlotte D

    2007-01-01

    with a contact allergic reaction, and the crescendo type of the response speaks in favour of an allergic nature. Further, 8 of the 31 (26%) developed long-lasting test reactions. A follow-up interview among 28/31 participants 10 years later showed that none had experienced long-term consequences in the form......In a skin irritancy study in healthy volunteers with 3 metal salts, aqueous gold sodium thiosulfate (GSTS) in a dilution series caused unexpectedly frequent and strong patch test reactions on volar forearm skin in 22 of 31 participants (71%). The reactions showed morphological features consistent...... of skin and/or mucosal complaints related to exposure to gold items. The results indicate that inclusion of GSTS in routine patch testing may cause problems regarding interpretation and clinical relevance of positive GSTS patch tests, which fulfil the clinical criteria of a contact allergy....

  3. How Does Patch Clamp Work?--An easy approach to understanding patch clamp mechanism

    Institute of Scientific and Technical Information of China (English)

    关兵才; 李之望

    2003-01-01

    In order to help patch clamp users,most of whom are not good enough at electrics and electronics,to understandthe complicated principles of patch clamp technique,we present a readily accessible explanation of patch clamp mechanism,in-cluding basic analysis of membrane currents under voltage clamp,achievement of voltage clamp and current recording,capaci-tance compensation,series resistance compensation,voltage offset correction,leak subtraction and current clamp,based on ourworking and teaching experience and with the aid of some useful formulae.

  4. Formation of patches on 3D SAMs driven by thiols with immiscible chains observed by ESR spectroscopy.

    Science.gov (United States)

    Gentilini, Cristina; Franchi, Paola; Mileo, Elisabetta; Polizzi, Stefano; Lucarini, Marco; Pasquato, Lucia

    2009-01-01

    Beyond stripes: The extreme lipophobicity of perfluorinated chains attached to amphiphilic thiolates triggers the formation of "stars" (or patches) surrounded by amphiphilic alkylthiolates in three-dimensional self-assembled monolayers. This strategy led to the first example of a water-soluble multicompartment monolayer wrapped around a gold core.

  5. Umbilical Hernia Repair with Proceed Ventral Patch

    Directory of Open Access Journals (Sweden)

    Salati Sajad Ahmad

    2014-07-01

    Full Text Available Umbilical hernia is one the commonest surgical lesions and there is a variety of methods available for its repair. Proceed Ventral Patch is a recent and novel innovation in hernia management and we present a successful management of umbilical hernia in a 45 years old obese patient with this technique

  6. Wireless Arm Patch May Blunt Migraine Pain

    Science.gov (United States)

    ... electrodes and a chip in the patch produce electric impulses that block pain signals from reaching the brain, the study authors said. When a migraine starts, you can control the intensity of the electric impulses using a smartphone app, explained lead researcher ...

  7. A method for detecting hydrophobic patches protein

    NARCIS (Netherlands)

    Lijnzaad, P.; Berendsen, H.J.C.; Argos, P.

    1996-01-01

    A method for the detection of hydrophobic patches on the surfaces of protein tertiary structures is presented, it delineates explicit contiguous pieces of surface of arbitrary size and shape that consist solely of carbon and sulphur atoms using a dot representation of the solvent-accessible surface,

  8. Soil, Seeds, and the Pumpkin Patch!

    Science.gov (United States)

    Phillips, Marianne; Vowell, Julie

    2013-01-01

    "Soil, Seeds, and the Pumpkin Patch!" is an integrated unit designed to provide elementary school teachers with ideas for using hands-on activities, fostering inquiry and valuable discussion, and using technology as a learning tool. This unit integrates science with language arts, mathematics, literature, and technology. During this unit, students…

  9. Capsaicin patch (Qutenza) for postherpetic neuralgia.

    Science.gov (United States)

    2011-05-30

    The FDA has approved a topical 8% patch formulation of capsaicin (Qutenza-NeurogesX), available only by prescription, for local treatment of postherpetic neuralgia. Postherpetic neuralgia occurs after herpes zoster in about one third of patients ≥60 years old and can persist for months or even years.

  10. Juno Microwave Radiometer Patch Array Antennas

    Science.gov (United States)

    Chamberlain, N.; Chen, J.; Focardi, P.; Hodges, R.; Hughes, R.; Jakoboski, J.; Venkatesan, J.; Zawadzki, M.

    2009-01-01

    Juno is a mission in the NASA New Frontiers Program with the goal of significantly improving our understanding of the formation and structure of Jupiter. This paper discusses the modeling and measurement of the two patch array antennas. An overview of the antenna architecture, design and development at JPL is provided, along with estimates of performance and the results of measurements.

  11. Bye-Bye Flu Shot, Hello Patch?

    Science.gov (United States)

    ... for intramuscular injection [a flu shot] by a health care professional," he added. Also, "this patch does not need to be refrigerated -- it has ... National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894 U.S. Department of Health and Human Services National Institutes of Health Page ...

  12. A method for detecting hydrophobic patches protein

    NARCIS (Netherlands)

    Lijnzaad, P.; Berendsen, H.J.C.; Argos, P.

    1996-01-01

    A method for the detection of hydrophobic patches on the surfaces of protein tertiary structures is presented, it delineates explicit contiguous pieces of surface of arbitrary size and shape that consist solely of carbon and sulphur atoms using a dot representation of the solvent-accessible surface,

  13. Abundance, distribution and patch formation of zooplankton

    Science.gov (United States)

    Paffenhöfer, Gustav-Adolf; Sherman, Byron K.; Lee, Thomas N.

    The goal of studies described here was to determine the responses of zooplankton taxa to phytoplankton patches which develop in and near intrusions of cold, nutrient-rich Gulf Stream water. To achieve this goal we determined the horizontal and vertical distributions of abundant mesozooplankton taxa on the south-eastern continental shelf of the USA between 29°30‧ and 31°N. The study period was from June 23 to August 16, 1981. Highest concentrations of zooplankton usually occurred in and near patches of phytoplankton. Increased phytoplankton appeared to trigger the formation of patches of the calanoid copepod Temora turbinata and the cyclopoid copepods Oithona spp. and Oncaea spp. The patches of zooplankton had greater alongshore than cross-shelf dimensions. T. turbinata responded rapidly to increased concentrations of phytoplankton by reproducing and aggregating in and above intruded waters. Oithonidae which were often, but not always, abundant in phytoplankton patches eventually attained high concentrations over most of the middle and part of the inner shelf. Their concentration and that of Oncaeidae increased steadily. Oncaeidae were not abundant in recently upwelled waters, as was T. turbinata but reached high concentrations in older intrusions when the abundance of T. turbinata remained level or decreased slowly. Both cyclopoid taxa are thought to reproduce slowly (egg sacs) compared to T. turbinata. Another taxon, the doliolids, became abundant far more rapidly in intruded waters (by asexual reproduction) than did the other three taxa. Doliolids were the most opportunistic intrusion zooplankton form. They do not regularly occur in low abundance on the shelf, as do the three copepod taxa, but develop in pulses in regions where T. turbinata and Oncaea are not abundant. Of the four taxa studied the abundance of doliolids increased and decreased most rapidly, whereas Oithona and Oncaea increased slowly and did not decrease during the study period. T. turbinata

  14. Genetics and Conservation of Plant Species of Extremely Narrow Geographic Range

    Directory of Open Access Journals (Sweden)

    Sofia Solórzano

    2016-12-01

    Full Text Available The endemic plant species with extremely narrow geographical range (<100 km2 often have few populations of small size and tend to be more vulnerable to extinction by genetic drift and inbreeding effects. For these species, we tested if intraspecific genetic diversity can be applied to identify conservation priorities. The biological model was Mammillaria albiflora—a Mexican cactus that numbers ~1000 individuals distributed in four nearby patches covering 4.3 km2. A total of 96 individuals were genotyped with 10 microsatellite loci to describe the genetic substructure and diversity. There is significant population substructure: the genetic diversity is distributed in three genetic neighbors and varies among the patches, the genotypes are not randomly distributed and three genetic barriers restrict the gene flow. The current population size is 15 times smaller than in the past. The restricted gene flow and genetic drift are the processes that have shaped population substructure. To conserve the genetic diversity of this cactus we recommend that two patches, which are not private property, be legally protected; to include M. albiflora in the Red List Species of Mexico in the category of extinction risk; and a legal propagation program may help to diminish the illegal harvesting.

  15. Magnetic Patches in Internetwork Quiet Sun

    Science.gov (United States)

    De Wijn, Alfred; Lites, B.; Berger, T.; Shine, R.; Title, A.; Katsukawa, Y.; Tsuneta, S.; Suematsu, Y.; Shimizu, T.; Hinode Team

    2007-05-01

    We study strong flux elements in the quiet sun in the context of the nature of quiet-sun magnetism, its coupling to chromospheric, transition-region and coronal fields, and the nature of a local turbulent dynamo. Strong, kilogauss flux elements show up intermittently as small bright points in G-band and Ca II H images. Although bright points have been extensively studied in the magnetic network, internetwork magnetism has only come under scrutiny in recent years. A full spectrum of field strengths seems to be ubiquitously present in the internetwork at small spatial scales, with the stronger elements residing in intergranular lanes. De Wijn et al. (2005) found that bright points in quiet sun internetwork areas appear recurrently with varying intensity and horizontal motion within long-lived patches that outline cell patterns on mesogranular scales. They estimate that the "magnetic patches" have a mean lifetime of nine hours, much longer than granular timescales. We use multi-hour sequences of G-band and Ca II H images as well as magnetograms recorded by the Hinode satellite to follow up on their results. The larger field of view, the longer sequences, the addition of magnetograms, and the absence of atmospheric seeing allows us to better constrain the patch lifetime, to provide much improved statistics on IBP lifetime, to compare IBPs to network bright points, and to study field polarity of IBPs in patches and between nearby patches. Hinode is an international project supported by JAXA, NASA, PPARC and ESA. We are grateful to the Hinode team for all their efforts in the design, build and operation of the mission.

  16. Patch-mosaic burning: a new paradigm for savanna fire management in protected areas?

    Directory of Open Access Journals (Sweden)

    C.L. Parr

    1999-02-01

    Full Text Available The shift in ecological thinking, from equilibrium to non-equilibrium processes has been accompanied by a move to encourage heterogeneity rather than homogeneity in landscapes. Spatial and temporal heterogeneity is thought to be a major source of biotic diversity, and disturbances such as fire, producing heterogeneity are now recognised as being important. A patch-mosaic system of burning is based on the premise that fire pattern is a surrogate for diversity, and produces a range of patches in the landscape with unique patch characteristics and fire histories. A patch-mosaic system of burning is supported historically and empirically through field studies. However, there is a need for more research into the effects of various aspects of patch and fire variables on biotic diversity, especially in savannas where our understanding is particularly poor. Landscape-scale experiments, like those to be established in the Kruger National Park, South Africa are necessary to test different burning regimes. Challenges to patch- mosaic burning include determining the 'natural' range of variation for fire parameters, implementing random ignitions, and cost-effective fire scar mapping at the appropriate resolution. An adaptive management approach should be adopted to deal with the ignorance and uncertainties that characterise the management of savanna ecosystems. This should be applied with both modelling and monitoring as key elements in this process.

  17. Multi-Band Miniaturized Patch Antennas for a Compact, Shielded Microwave Breast Imaging Array.

    Science.gov (United States)

    Aguilar, Suzette M; Al-Joumayly, Mudar A; Burfeindt, Matthew J; Behdad, Nader; Hagness, Susan C

    2013-12-18

    We present a comprehensive study of a class of multi-band miniaturized patch antennas designed for use in a 3D enclosed sensor array for microwave breast imaging. Miniaturization and multi-band operation are achieved by loading the antenna with non-radiating slots at strategic locations along the patch. This results in symmetric radiation patterns and similar radiation characteristics at all frequencies of operation. Prototypes were fabricated and tested in a biocompatible immersion medium. Excellent agreement was obtained between simulations and measurements. The trade-off between miniaturization and radiation efficiency within this class of patch antennas is explored via a numerical analysis of the effects of the location and number of slots, as well as the thickness and permittivity of the dielectric substrate, on the resonant frequencies and gain. Additionally, we compare 3D quantitative microwave breast imaging performance achieved with two different enclosed arrays of slot-loaded miniaturized patch antennas. Simulated array measurements were obtained for a 3D anatomically realistic numerical breast phantom. The reconstructed breast images generated from miniaturized patch array data suggest that, for the realistic noise power levels assumed in this study, the variations in gain observed across this class of multi-band patch antennas do not significantly impact the overall image quality. We conclude that these miniaturized antennas are promising candidates as compact array elements for shielded, multi-frequency microwave breast imaging systems.

  18. Comparison of 24-hour Holter monitoring with 14-day novel adhesive patch electrocardiographic monitoring.

    Science.gov (United States)

    Barrett, Paddy M; Komatireddy, Ravi; Haaser, Sharon; Topol, Sarah; Sheard, Judith; Encinas, Jackie; Fought, Angela J; Topol, Eric J

    2014-01-01

    Cardiac arrhythmias are remarkably common and routinely go undiagnosed because they are often transient and asymptomatic. Effective diagnosis and treatment can substantially reduce the morbidity and mortality associated with cardiac arrhythmias. The Zio Patch (iRhythm Technologies, Inc, San Francisco, Calif) is a novel, single-lead electrocardiographic (ECG), lightweight, Food and Drug Administration-cleared, continuously recording ambulatory adhesive patch monitor suitable for detecting cardiac arrhythmias in patients referred for ambulatory ECG monitoring. A total of 146 patients referred for evaluation of cardiac arrhythmia underwent simultaneous ambulatory ECG recording with a conventional 24-hour Holter monitor and a 14-day adhesive patch monitor. The primary outcome of the study was to compare the detection arrhythmia events over total wear time for both devices. Arrhythmia events were defined as detection of any 1 of 6 arrhythmias, including supraventricular tachycardia, atrial fibrillation/flutter, pause greater than 3 seconds, atrioventricular block, ventricular tachycardia, or polymorphic ventricular tachycardia/ventricular fibrillation. McNemar's tests were used to compare the matched pairs of data from the Holter and the adhesive patch monitor. Over the total wear time of both devices, the adhesive patch monitor detected 96 arrhythmia events compared with 61 arrhythmia events by the Holter monitor (P Holter monitor. Prolonged duration monitoring for detection of arrhythmia events using single-lead, less-obtrusive, adhesive-patch monitoring platforms could replace conventional Holter monitoring in patients referred for ambulatory ECG monitoring. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Predator-prey interactions shape thermal patch use in a newt larvae-dragonfly nymph model.

    Directory of Open Access Journals (Sweden)

    Lumír Gvoždík

    Full Text Available Thermal quality and predation risk are considered important factors influencing habitat patch use in ectothermic prey. However, how the predator's food requirement and the prey's necessity to avoid predation interact with their respective thermoregulatory strategies remains poorly understood. The recently developed 'thermal game model' predicts that in the face of imminent predation, prey should divide their time equally among a range of thermal patches. In contrast, predators should concentrate their hunting activities towards warmer patches. In this study, we test these predictions in a laboratory setup and an artificial environment that mimics more natural conditions. In both cases, we scored thermal patch use of newt larvae (prey and free-ranging dragonfly nymphs (predators. Similar effects were seen in both settings. The newt larvae spent less time in the warm patch if dragonfly nymphs were present. The patch use of the dragonfly nymphs did not change as a function of prey availability, even when the nymphs were starved prior to the experiment. Our behavioral observations partially corroborate predictions of the thermal game model. In line with asymmetric fitness pay-offs in predator-prey interactions (the 'life-dinner' principle, the prey's thermal strategy is more sensitive to the presence of predators than vice versa.

  20. Predator-prey interactions shape thermal patch use in a newt larvae-dragonfly nymph model.

    Science.gov (United States)

    Gvoždík, Lumír; Černická, Eva; Van Damme, Raoul

    2014-01-01

    Thermal quality and predation risk are considered important factors influencing habitat patch use in ectothermic prey. However, how the predator's food requirement and the prey's necessity to avoid predation interact with their respective thermoregulatory strategies remains poorly understood. The recently developed 'thermal game model' predicts that in the face of imminent predation, prey should divide their time equally among a range of thermal patches. In contrast, predators should concentrate their hunting activities towards warmer patches. In this study, we test these predictions in a laboratory setup and an artificial environment that mimics more natural conditions. In both cases, we scored thermal patch use of newt larvae (prey) and free-ranging dragonfly nymphs (predators). Similar effects were seen in both settings. The newt larvae spent less time in the warm patch if dragonfly nymphs were present. The patch use of the dragonfly nymphs did not change as a function of prey availability, even when the nymphs were starved prior to the experiment. Our behavioral observations partially corroborate predictions of the thermal game model. In line with asymmetric fitness pay-offs in predator-prey interactions (the 'life-dinner' principle), the prey's thermal strategy is more sensitive to the presence of predators than vice versa.

  1. Developing a Nicotine Patch Adherence Intervention for HIV-positive Latino Smokers

    Science.gov (United States)

    Shadel, William G.; Galvan, Frank H.; Tucker, Joan S.

    2016-01-01

    This paper describes two phases of formative research that were undertaken to develop a smoking cessation treatment module that has the goal of improving adherence with the nicotine patch in HIV-positive Latino smokers. Each research phase (Phase I and II) was conducted independent of the other and used different methods to inform the development of the intervention. Phase I interviewed n=14 smokers who had previous experience using the nicotine patch to gain detailed understanding of how, when, and why they used it; their perceived barriers to using it; and their perspective on ways to improve adherence to it. Phase II provided n=35 smokers with brief smoking cessation treatment and nicotine patches, then interviewed them in “near real time” over a two month period about their use of the patch during a quit attempt (e.g., perceived barriers and facilitators). Authors of the paper conducted a qualitative analysis of the themes emerging from the interview transcripts across these two phases. Results indicated that consistent use of the nicotine patch was associated with maintaining high motivation for use (i.e., not necessarily motivation to quit, but motivation to continue patch use); linking its use with established daily routines (e.g., with taking other medications, with brushing teeth); and maintaining realistic expectations for patch efficacy (e.g., that users may still experience some level of craving and/or withdrawal). This information will used to develop and pilot test a brief treatment module that focuses on improving nicotine patch adherence. PMID:27070097

  2. Light transmission and preference of eye patches for occlusion treatment.

    Directory of Open Access Journals (Sweden)

    Hwan Heo

    Full Text Available PURPOSE: To investigate light transmission and preference for six eye patches for occlusion therapy. METHODS: Six patches were examined, including; Ortopad Fun Pack, Ortopad Flesh, Kawamoto A-1, Kawamoto A-2, 3M Opticlude, and Everade Eye Guard. The size and the presence of a light blocking pad of patches were investigated. The amount of light transmitted through the patches was evaluated, using a digital light meter and a model eye, in three different environments; indoors with fluorescent light, outdoors on a sunny day, and strong light from illuminator. After patching the normal eye, the flash visual evoked potential (VEP was measured. Thirty patients with amblyopia or horizontal strabismus, who received occlusion therapy as initial treatment, were included. After using all six patches, patients completed a 7-item questionnaire regarding the patch preference for size, color and shape, adhesive power, pain with removal, skin irritation after removing patch, parent's preference and overall opinion. RESULTS: All patches had a light-blocking pad, except the 3M Nexcare. Ortopad had the strongest light blocking power in the three environments, and the 3M Nexcare had the weakest power. In flash VEP, Ortopad and Kawamoto patches showed flat, but 3M Nexcare and Everade Eye Guard showed normal response. There were significant preferential differences among the patches in all the items of the questionnaire (P<0.05. In comparison between the patches respectively, 3M Nexcare received the lowest satisfaction in pain when removing a patch and skin irritation after removing a patch. Kawamoto A-2 received the lowest score in the overall satisfaction. CONCLUSIONS: We found differences in the light-blocking power and in the preference of the various patches for the occlusion treatment. This is a pilot study regarding only characteristics and preferences of patches. Further clinical studies regarding the relationship between characteristics or preferences of

  3. Effect of eye patching in rehabilitation of neglect

    Directory of Open Access Journals (Sweden)

    Nicola eSmania

    2013-09-01

    Full Text Available Eye patching (monocular or right hemifield has been proposed to improve visuospatial attention to the ignored field in patients with neglect. The aim of this paper is to review the literature on the effects of eye patching in hemispatial neglect after stroke in order to convey evidence-based recommendations to clinicians in stroke rehabilitation. Thirteen intervention studies were selected from the Medline, EMBASE, Scopus, Cochrane Library, CINAHL, PsychINFO, EBRSR and Health Star databases. Methodological quality was defined according to the Physiotherapy Evidence Database. Overall, seven studies used monocular eye patching, five used right hemifield patching and one compared right monocular with right hemifield patching. Seven studies compared normal viewing to monocular or hemifield patching conditions. Six studies included a period of treatment. Three studies included follow-up evaluations. As to the monocular eye patching, four studies reported positive effects of right monocular patching. One study showed an improvement in hemispatial neglect with left monocular patching. Two studies found no superiority of right versus left monocular patching. One study found no effects of right monocular patching. As to the right hemifield eye patching, one study showed improvements in neglect after right hemifield patching. Three studies found that right hemifield patching combined with another rehabilitation technique was more effective than that treatment alone. One study found no differences between right hemifield patching combined with another treatment and that treatment alone. One study found the same effect between right hemifield patching alone and another rehabilitation technique.Our results globally tend to support the usefulness of right hemifield eye patching in clinical practice. In order to define a level of evidence with the standard rehabilitation evidence rating tools, further properly powered randomized controlled trials or meta

  4. Emergent properties of patch shapes affect edge permeability to animals.

    Directory of Open Access Journals (Sweden)

    Vilis O Nams

    Full Text Available Animal travel between habitat patches affects populations, communities and ecosystems. There are three levels of organization of edge properties, and each of these can affect animals. At the lowest level are the different habitats on each side of an edge, then there is the edge itself, and finally, at the highest level of organization, is the geometry or structure of the edge. This study used computer simulations to (1 find out whether effects of edge shapes on animal behavior can arise as emergent properties solely due to reactions to edges in general, without the animals reacting to the shapes of the edges, and to (2 generate predictions to allow field and experimental studies to test mechanisms of edge shape response. Individual animals were modeled traveling inside a habitat patch that had different kinds of edge shapes (convex, concave and straight. When animals responded edges of patches, this created an emergent property of responding to the shape of the edge. The response was mostly to absolute width of the shapes, and not the narrowness of them. When animals were attracted to edges, then they tended to collect in convexities and disperse from concavities, and the opposite happened when animals avoided edges. Most of the responses occurred within a distance of 40% of the perceptual range from the tip of the shapes. Predictions were produced for directionality at various locations and combinations of treatments, to be used for testing edge behavior mechanisms. These results suggest that edge shapes tend to either concentrate or disperse animals, simply because the animals are either attracted to or avoid edges, with an effect as great as 3 times the normal density. Thus edge shape could affect processes like pollination, seed predation and dispersal and predator abundance.

  5. Binary black hole coalescence in the extreme-mass-ratio limit: testing and improving the effective-one-body multipolar waveform

    CERN Document Server

    Bernuzzi, Sebastiano; Zenginoglu, Anil

    2010-01-01

    We discuss the properties of the effective-one-body (EOB) multipolar gravitational waveform emitted by nonspinning black-hole binaries of masses $\\mu$ and $M$ in the extreme-mass-ratio limit, $\\mu/M=\

  6. Development and evaluation of a patching treatment questionnaire for Chinese amblyopic children

    Institute of Scientific and Technical Information of China (English)

    Xu Jinling; Lu Qun; Huang Ying; Chen Yuanyuan; Chen Jie; Yu Xinping

    2014-01-01

    Background Amblyopia is a common disease for children.The main treatment approach for amblyopia is to patch the normally sighted eye and force the use of the amblyopic eye.However,patching treatment in children may negatively impact psychological well-being of both the child and family.At present,no specific questionnaire is available to assess the health-related quality of life (HRQoL) of amblyopic treatment for children and their families in China.The purpose of our study was to develop a Chinese version of patching treatment questionnaire,and evaluate its reliability and validity.Methods The original patching treatment questionnaire of amblyopia treatment index (ATI) was translated into Chinese.Amblyopic patients aged 4-9 years receiving patching 4-8 hours per day or full-time were recruited.The reliability and validity of the Chinese version of the patching treatment questionnaire were determined by internal consistency,test-retest reliability,item-scale correlations,and construct validity.The associated baseline factors and the questionnaire responses were assessed.Results One hundred and nine children with amblyopia treated with patching were enrolled.Distribution of response options for individual items and correlation with the respective subscale were calculated.Factor analysis revealed that 16 of the 21 items were loaded in the three subscales as follows:"adverse effects" of treatment,“difficulties with compliance" and "social stigma" of treatment.Intemal consistency values measured by Cronbach's a coefficient (0.768) and split-half coefficient (0.790) were satisfactory for the total scales.The intra-class correlation coefficient for test-retest reliability was 0.998.No significant difference was found between the overall questionnaire scores and children's age,sex,baseline visual acuity of amblyopic eyes,improvement of the amblyopic eye,or patching time.Conclusions We developed a Chinese version of the patching treatment questionnaire with satisfactory

  7. A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field.

    Science.gov (United States)

    Choleris, E; Thomas, A W; Kavaliers, M; Prato, F S

    2001-05-01

    The open field test (OFT) is a widely used procedure for examining the behavioral effects of drugs and anxiety. Detailed ethological assessments of animal behavior are lacking. Here we present a detailed ethological assessment of the effects of acute treatment with the benzodiazepines, diazepam (DZ, 1.5mg/kg) and chlordiazepoxide (CDP, 5.0 and 10.0mg/kg), as well as exposure to a non-pharmacological agent, a specific pulsed extremely low frequency magnetic field (MAG) on open field behavior. We examined the duration, frequency and time course of various behaviors (i.e. exploration, walk, rear, stretch attend, return, groom, sit, spin turn, jump and sleep) exhibited by male mice in different regions of a novel open field. Both DZ and CDP consistently reduced the typical anxiety-like behaviors of stretch attend and wall-following (thigmotaxis), along with that of an additional new measure: 'returns', without producing any overall effects on total locomotion. The drugs also differed in their effects. CDP elicited a shift in the locomotor pattern from a 'high explore' to a 'high walk', while DZ mainly elicited alterations in sit and groom. The MAG treatment was repeated twice with both exposures reducing horizontal and vertical (rearing) activity and increasing grooming and spin turns. However, the anxiety-like behaviors of stretch attend and return were marginally reduced by only the first exposure. We conclude that a detailed ethological analysis of the OFT allows not only the detection of specific effects of drugs and non-pharmacological agents (i.e. pulsed magnetic field) on anxiety-like behaviors, but also permits the examination of non-specific effects, in particular those on general activity.

  8. Studying mechanosensitive ion channels with an automated patch clamp

    NARCIS (Netherlands)

    Barthmes, Maria; Jose, Mac Donald F; Birkner, Jan Peter; Brüggemann, Andrea; Wahl-Schott, Christian; Kocer, Armagan

    2014-01-01

    Patch clamp electrophysiology is the main technique to study mechanosensitive ion channels (MSCs), however, conventional patch clamping is laborious and success and output depends on the skills of the operator. Even though automated patch systems solve these problems for other ion channels, they cou

  9. Smooth surfaces from rational bilinear patches

    KAUST Repository

    Shi, Ling

    2014-01-01

    Smooth freeform skins from simple panels constitute a challenging topic arising in contemporary architecture. We contribute to this problem area by showing how to approximate a negatively curved surface by smoothly joined rational bilinear patches. The approximation problem is solved with help of a new computational approach to the hyperbolic nets of Huhnen-Venedey and Rörig and optimization algorithms based on it. We also discuss its limits which lie in the topology of the input surface. Finally, freeform deformations based on Darboux transformations are used to generate smooth surfaces from smoothly joined Darboux cyclide patches; in this way we eliminate the restriction to surfaces with negative Gaussian curvature. © 2013 Elsevier B.V.

  10. Mesh saliency with adaptive local patches

    Science.gov (United States)

    Nouri, Anass; Charrier, Christophe; Lézoray, Olivier

    2015-03-01

    3D object shapes (represented by meshes) include both areas that attract the visual attention of human observers and others less or not attractive at all. This visual attention depends on the degree of saliency exposed by these areas. In this paper, we propose a technique for detecting salient regions in meshes. To do so, we define a local surface descriptor based on local patches of adaptive size and filled with a local height field. The saliency of mesh vertices is then defined as its degree measure with edges weights computed from adaptive patch similarities. Our approach is compared to the state-of-the-art and presents competitive results. A study evaluating the influence of the parameters establishing this approach is also carried out. The strength and the stability of our approach with respect to noise and simplification are also studied.

  11. Tunable Patch Antennas Using Microelectromechanical Systems

    Science.gov (United States)

    2011-05-11

    wavelength of the desired resonant frequency [1]. (25) To aid in the design process a MATLAB script was written to solve for patch antenna...10–12, the widths of 50 Ω and 112 Ω microstrip lines were calculated using a MATLAB script included as an appendix to this report. The calculated...2009, pp. 50–55. [11] W.L. Stutzman, G.A. Thiele , Antenna Theory and Design, Second Edition, John Wiley & Sons, Inc. (Hoboken, New Jersey), 1998, pp

  12. Design of an innovative magnetostrictive patch actuator

    Science.gov (United States)

    Cinquemani, S.; Giberti, H.

    2015-04-01

    Magnetostrictive actuators can be profitably used to reduce vibration in structures. However, this technology has been exploited only to develop inertial actuators, while patches actuators have not been ever used in practice. Patches actuators consist on a layer of magnetostrictive material, which has to be stuck to the surface of the vibrating structure, and on a coil surrounding the layer itself. However, the presence of the winding severely limits the use of such devices. As a matter of fact, the scientific literature reports only theoretical uses of such actuators, but, in practice it does not seem they were ever used. This paper presents an innovative solution to improve the structure of the actuator patches, allowing their use in several practical applications. The principle of operation of these devices is rather simple. The actuator patch is able to generate a local deformation of the surface of the vibrating structure so as to introduce an equivalent damping that dissipates the kinetic energy associated to the vibration. This deformation is related to the behavior of the magnetostrictive material immersed in a variable magnetic field generated by the a variable current flowing in the winding. Contrary to what suggested in the theoretical literature, the designed device has the advantage of generating the variable magnetic field no longer in close proximity of the material, but in a different area, thus allowing a better coupling. The magnetic field is then conveyed through a suitable ferromagnetic structure to the magnetostrictive material. The device has been designed and simulated through FEA. Results confirm that the new configuration can easily overcome all the limits of traditional devices.

  13. Broadband Circularly Polarized Patch Antenna and Method

    Science.gov (United States)

    2016-09-16

    embodiment further includes a series of coupling layers 24A, 24B and 24C of low dielectric constant spacers 26 and parallel high dielectric constant...as that used to make a printed circuit board. [0005] A common means of obtaining a circularly polarized signal from a rectangular patch antenna of...in a single plane, coplanar with the emitter, and parallel to the dominant current distribution when the emitter is active. Further coupling layers

  14. Aortic aneurysm after patch aortoplasty for coarctation: analysis of patch size and wall growth.

    Science.gov (United States)

    Al-Hroob, A; Husayni, T S; Freter, A; Chiemmongkoltip, P; Ilbawi, M N; Arcilla, R A

    2003-01-01

    Aortic aneurysm may develop after surgery for coarctation of aorta especially patch aortoplasty. The size of patch and of adjacent native aortic wall was analyzed to determine whether aortic dilatation represents a true aneurysm. Electron beam tomography (EBT) was done on 19 patients, three months to 17.5 years after patch aortoplasty. Tomograms of aorta were obtained in 6-mm slices, and maximal cross-sectional area was digitized to obtain: total circumference (Ct), patch component (Cp), and aortic wall component (Cw). Ct, Cp, and Cw were normalized to the circumference of distal aorta (Cda) as: isthmus/distal aorta (Ct/Cda), patch segment/distal aorta (Cp/Cda), wall segment/distal aorta (Cw/Cda). Ct/Cda ranged from 109% to 260%. In 12 patients (group A), it varied from 168% to 260%; and in seven (group B), 109% to 133%. There was strong correlation (r = 0.92) between Ct/Cda and Cp/Cda. Ct/Cda, Cp/Cda, and Cp/Cw were higher in group A than B (p <0.001) but Cw/Cda did not differ. Cw/Cda was greater than the coarctation/distal aorta diameter ratios of preoperative angiograms, consistent with accelerated aortic wall growth postsurgery. No definite aneurysm was seen. Localized dilatation of aorta following patch aortoplasty in children is primarily due to a large synthetic patch and, partly, to increased aortic wall growth. Serial EBT or magnetic resonance imaging is indicated to monitor aortic wall growth and occurrence of aneurysm.

  15. Optimal patch code design via device characterization

    Science.gov (United States)

    Wu, Wencheng; Dalal, Edul N.

    2012-01-01

    In many color measurement applications, such as those for color calibration and profiling, "patch code" has been used successfully for job identification and automation to reduce operator errors. A patch code is similar to a barcode, but is intended primarily for use in measurement devices that cannot read barcodes due to limited spatial resolution, such as spectrophotometers. There is an inherent tradeoff between decoding robustness and the number of code levels available for encoding. Previous methods have attempted to address this tradeoff, but those solutions have been sub-optimal. In this paper, we propose a method to design optimal patch codes via device characterization. The tradeoff between decoding robustness and the number of available code levels is optimized in terms of printing and measurement efforts, and decoding robustness against noises from the printing and measurement devices. Effort is drastically reduced relative to previous methods because print-and-measure is minimized through modeling and the use of existing printer profiles. Decoding robustness is improved by distributing the code levels in CIE Lab space rather than in CMYK space.

  16. Modular assembly of thick multifunctional cardiac patches

    Science.gov (United States)

    Fleischer, Sharon; Shapira, Assaf; Feiner, Ron; Dvir, Tal

    2017-01-01

    In cardiac tissue engineering cells are seeded within porous biomaterial scaffolds to create functional cardiac patches. Here, we report on a bottom-up approach to assemble a modular tissue consisting of multiple layers with distinct structures and functions. Albumin electrospun fiber scaffolds were laser-patterned to create microgrooves for engineering aligned cardiac tissues exhibiting anisotropic electrical signal propagation. Microchannels were patterned within the scaffolds and seeded with endothelial cells to form closed lumens. Moreover, cage-like structures were patterned within the scaffolds and accommodated poly(lactic-co-glycolic acid) (PLGA) microparticulate systems that controlled the release of VEGF, which promotes vascularization, or dexamethasone, an anti-inflammatory agent. The structure, morphology, and function of each layer were characterized, and the tissue layers were grown separately in their optimal conditions. Before transplantation the tissue and microparticulate layers were integrated by an ECM-based biological glue to form thick 3D cardiac patches. Finally, the patches were transplanted in rats, and their vascularization was assessed. Because of the simple modularity of this approach, we believe that it could be used in the future to assemble other multicellular, thick, 3D, functional tissues. PMID:28167795

  17. Formulation, in vitro and in vivo evaluation of transdermal patches containing risperidone.

    Science.gov (United States)

    Aggarwal, Geeta; Dhawan, Sanju; Hari Kumar, S L

    2013-01-01

    The efficacy of oral risperidone treatment in prevention of schizophrenia is well known. However, oral side effects and patient compliance is always a problem for schizophrenics. In this study, risperidone was formulated into matrix transdermal patches to overcome these problems. The formulation factors for such patches, including eudragit RL 100 and eudragit RS 100 as matrix forming polymers, olive oil, groundnut oil and jojoba oil in different concentrations as enhancers and amount of drug loaded were investigated. The transdermal patches containing risperidone were prepared by solvent casting method and characterized for physicochemical and in vitro permeation studies through excised rat skin. Among the tested preparations, formulations with 20% risperidone, 3:2 ERL 100 and ERS 100 as polymers, mixture of olive oil and jojoba oil as enhancer, exhibited greatest cumulative amount of drug permeated (1.87 ± 0.09 mg/cm(2)) in 72 h, so batch ROJ was concluded as optimized formulation and assessed for pharmacokinetic, pharmacodynamic and skin irritation potential. The pharmacokinetic characteristics of the optimized risperidone patch were determined using rabbits, while orally administered risperidone in solution was used for comparison. The calculated relative bioavailability of risperidone transdermal patch was 115.20% with prolonged release of drug. Neuroleptic efficacy of transdermal formulation was assessed by rota-rod and grip test in comparison with control and marketed oral formulations with no skin irritation. This suggests the transdermal application of risperidone holds promise for improved bioavailability and better management of schizophrenia in long-term basis.

  18. Miniaturization of Multiple-Layer Folded Patch Antennas

    DEFF Research Database (Denmark)

    Zhang, Jiaying; Breinbjerg, Olav

    2009-01-01

    A new folded patch antenna with multiple layers was developed in this paper, by folding the patch in a proper way, and a highly miniaturized antenna can be realized. The multiple layer patch with 4-layer and 6-layer are designed and evaluated at 2.4 GHz, 915 MHz, and 415 MHz respectively. Then a 4...... layer patch is fabricated and measured to validate the design method. The theoretical analysis, design and simulations, fabrications, as well as the measurements are presented in this paper. All the results show that the folded patch antenna is a good candidate in making a highly miniaturized compact...... antenna....

  19. Single image super-resolution based on image patch classification

    Science.gov (United States)

    Xia, Ping; Yan, Hua; Li, Jing; Sun, Jiande

    2017-06-01

    This paper proposed a single image super-resolution algorithm based on image patch classification and sparse representation where gradient information is used to classify image patches into three different classes in order to reflect the difference between the different types of image patches. Compared with other classification algorithms, gradient information based algorithm is simpler and more effective. In this paper, each class is learned to get a corresponding sub-dictionary. High-resolution image patch can be reconstructed by the dictionary and sparse representation coefficients of corresponding class of image patches. The result of the experiments demonstrated that the proposed algorithm has a better effect compared with the other algorithms.

  20. Computer-aided patch planning for treatment of complex coarctation of the aorta

    Science.gov (United States)

    Rietdorf, Urte; Riesenkampff, Eugénie; Kuehne, Titus; Huebler, Michael; Meinzer, Hans-Peter; Wolf, Ivo

    2009-02-01

    Between five and eight percent of all children born with congenitally malformed hearts suffer from coarctations of the aorta. Some severe coarctations can only be treated by surgical repair. Untreated, this defect can cause serious damage to organ development or even lead to death. Patch repair requires open surgery. It can affect patients of any age: newborns with severe coarctation and/or hypoplastic aortic arch as well as older patients with late diagnosis of coarctation of the aorta. Another patient group are patients of varying age with re-coarctation of the aorta or hypoplastic aortic arch after surgical and/or interventional repair. If anatomy is complex and interventional treatment by catheterization, balloon angioplasty or stent placement is not possible, surgery is indicated. The choice of type of surgery depends not only on the given anatomy but also on the experience the surgical team has with each method. One surgical approach is patch repair. A patch of a suitable shape and size is sewed into the aorta to expand the aortic lumen at the site of coarctation. At present, the shape and size of the patch are estimated intra-operatively by the surgeon. We have developed a software application that allows planning of the patch pre-operatively on the basis of magnetic resonance angiographic data. The application determines the diameter of the coarctation and/or hypoplastic segment and constructs a patch proposal by calculating the difference to the normal vessel diameter pre-operatively. Evaluation of MR angiographic datasets from 12 test patients with different kinds of aortic arch stenosis shows a divergence of only (1.5+/-1.2) mm in coarctation diameters between manual segmentations and our approach, with comparable time expenditure. Following this proposal the patch can be prepared and adapted to the patient's anatomy pre-operatively. Ideally, this leads to shorter operation times and a better long-term outcome with a reduced rate of residual stenosis and