WorldWideScience

Sample records for extraterrestrische physik mpe

  1. Gerthsen Physik

    CERN Document Server

    2015-01-01

    Auf mehr als 1000 Seiten findet man von der Kinematik des Massenpunktes über die Quantenchromodynamik, die Fullerene, die Halbleiterlaser, die Hochtemperatur-Supraleiter bis hin zum Chaos im Kochtopf praktisch alles, was Physik heute ausmacht. ... In diesem sehr weit gespannten Bogen nimmt der Gerthsen den Platz eines echten, ja eigentlich des einzigen Kompendiums der Physik ein. Kein Physiker kommt heute noch ohne dieses Werk aus. (Physikalische Blätter) Für die Studierenden der Physik im Haupt- und Nebenfach ist der Gerthsen ein unverzichtbarer und kompetenter Begleiter durch das gesamte Studium, das jetzt in der Neuauflage noch preisgünstiger zu erwerben ist. Nahezu alle Studierenden beginnen mit dem Klassiker Gerthsen. Sämtliche Gebiete der Physik werden ausführlich und gut verständlich dargestellt. Das Buch stellt alle klassischen Themen vor - Mechanik, Wärmelehre, Elektrodynamik, Optik. Darauf aufbauende Themen der klassischen Physik wie die Nichtlineare Dynamik und die Relativitätstheorie sin...

  2. Faszination Physik

    CERN Document Server

    2004-01-01

    30 von renommierten Experten verfasste Essayartikel liefern einen integrierenden Überblick über einzelne Fachgebiete und Aspekte der Physik oder widmen sich aktuellen Forschungsgebieten. Das Themengebiet reicht dabei von der Teilchenphysik über Fullerene und Biophysik bis hin zur Bose-Einstein-Kondensation und Quanteninformatik. Die Faszination Physik richtet sich an Studierende der Physik und an alle, die sich für Experimente und Erkenntnisse in der Physik begeistern können und will explizit zum Schmökern und ausführlichen Nachlesen einladen. Katja Bammel, fertigte ihre Diplomarbeit am Max-Planck-Institut für Strömungsphysik in Göttingen an und promovierte an der FU Berlin. Seit 1999 lebt sie mit ihrer Familie in Cagliari (Italien) und arbeitet als freie Wissenschaftsjournalistin. Erste Erfahrungen in diesem Bereich sammelte sie schon zuvor als Autorin für Lexikon der Physik. Seitdem wirkte sie an weiteren Nachschlagwerken wie Der Brockhaus Naturwissenschaft und Technik und dem Lexikon bedeutender...

  3. Donnerwetter - Physik!

    CERN Document Server

    Peter Häussler

    2001-01-01

    Auf einer Geburtstagsparty werden Jugendlichen sieben Zauberkunststücke vorgeführt. Sieben erstaunliche Phänomene, die Anne und ihre Freunde zunächst vor Rätsel stellen. Doch so nach und nach kommen sie den Tricks auf die Spur. Mit der Unterstützung eines Nachbarn, einem pensionierten Physiker, entwickeln sie dazu physikalische Ideen: Anhand des Gewichts von Schokolade wird die Einheit für die Kraft diskutiert, "Schau mir in die Augen" leitet ein Gespräch über die Bildentstehung ein. Das Beobachten von Zugvögeln ist Aufhänger für den Magnetismus, und ein heftiges Gewitter gibt Anlass zum Nachdenken über die Elektrizität. Auch die von Physikern entwickelten Vorstellungen zu Quarks, Weißen Zwergen und Schwarzen Löchern kommen zur Sprache. Peter Häußler ist Professor für die Didaktik der Physik an der Universität Kiel und versteht es, lebendig und spannend zu schreiben. Über die Grundlagen der Physik hinaus erfährt der Leser auch etwas über ihre Erkenntnismethoden und den Unterschied zwisc...

  4. Physik ein Lehrbuch

    CERN Document Server

    Westphal, Wilhelm H

    1953-01-01

    Mechanik der Massenpunkte und der starren Körper ; Physik der Stoffe ; Wärmelehre ; Elektrostatik ; Magnetismus und Elektrodynamik ; Optik und allgemeine Strahlungslehre ; Quantentheorie, Atome und Moleküle, Kristalle ; Astrophysik und Physik des Weltalls.

  5. Ideengeschichte der Physik

    CERN Document Server

    Kuhn, Wildfried

    2016-01-01

    Die Ideengeschichte der Physik geht neue Wege, indem sie den umfangreichen historischen Stoff nicht additiv darstellt, sondern wissenschaftstheoretisch reflektiert und nach thematischen Leitlinien (Materievorstellungen, Raum und Zeit, Erhaltungskonzepte, Extremalprinzipien, Theorie und Experiment) strukturiert. Damit vermittelt diese Darstellung im historischen Kontext ein tieferes Verständnis des physikalischen Denkens von der Antike bis heute und lotet zugleich die Dimension der Genesis physikalischer Begriffe aus, die in modernen Lehrbüchern zumeist nicht dargelegt wird. Das Credo Kuhns: Wer über die handwerkliche Handhabung von Physik hinausgehen will, muss sich zwingend mit der Frage befassen, was physikalisches Denken ausmacht und wie es entstanden ist. Die vorliegende zweite Auflage wurde ergänzt durch ein Vorwort von Prof. Dr. Oliver Schwarz, der im Institut Wilfried Kuhns forschen konnte und dabei dessen Denk- und Arbeitsweisen kennengelernt hat.

  6. Moderne mathematische Methoden der Physik

    CERN Document Server

    Goldhorn, Karl-Heinz; Kraus, Margarita

    2010-01-01

    Der große Vorzug dieses Lehrbuchs liegt in seiner kompromisslosen Konzentration auf begriffliche Klarheit bei bewusstem Verzicht auf für Physiker irrelevante Details. Es richtet sich u.a. an Studierende von Master-, Aufbau-, Graduierten- und Promotionsstudiengängen im Bereich der theoretischen und mathematischen Physik. Die Auswahl des Stoffes deckt ein breites Spektrum mathematischer Konzepte und Methoden ab, die für die heutige Physik relevant sind. Dieser zweite Band konzentriert sich dabei auf mathematische Grundlagen der Quantenmechanik: Unbeschränkte Operatoren im Hilbertraum, Spektraltheorie sowie Symmetriegruppen und ihre Darstellungen mit besonderem Augenmerk auf Rotations- und Lorentzgruppe.

  7. MPE inference in conditional linear gaussian networks

    DEFF Research Database (Denmark)

    Salmerón, Antonio; Rumí, Rafael; Langseth, Helge

    2015-01-01

    Given evidence on a set of variables in a Bayesian network, the most probable explanation (MPE) is the problem of finding a configuration of the remaining variables with maximum posterior probability. This problem has previously been addressed for discrete Bayesian networks and can be solved usin...

  8. mpe-Bjørneklo

    DEFF Research Database (Denmark)

    Nielsen, Charlotte; Ravn, Hans Peter; Nentwig, Wolfgang

    Hæftet fremlægger i kort form den aktuelle viden om alle relevante aspekter af Kæmpe-Bjørneklos biologi, økologi, taksonomi plus håndtering og bekæmpelse. Vi håber, det kan skabe forståelse blandt myndigheder på alle niveauer og private jordejere for nødvendigheden af overordnede strategier frem ...

  9. Proceedings of the third international molecular pathological epidemiology (MPE) meeting.

    Science.gov (United States)

    Campbell, Peter T; Rebbeck, Timothy R; Nishihara, Reiko; Beck, Andrew H; Begg, Colin B; Bogdanov, Alexei A; Cao, Yin; Coleman, Helen G; Freeman, Gordon J; Heng, Yujing J; Huttenhower, Curtis; Irizarry, Rafael A; Kip, N Sertac; Michor, Franziska; Nevo, Daniel; Peters, Ulrike; Phipps, Amanda I; Poole, Elizabeth M; Qian, Zhi Rong; Quackenbush, John; Robins, Harlan; Rogan, Peter K; Slattery, Martha L; Smith-Warner, Stephanie A; Song, Mingyang; VanderWeele, Tyler J; Xia, Daniel; Zabor, Emily C; Zhang, Xuehong; Wang, Molin; Ogino, Shuji

    2017-02-01

    Molecular pathological epidemiology (MPE) is a transdisciplinary and relatively new scientific discipline that integrates theory, methods, and resources from epidemiology, pathology, biostatistics, bioinformatics, and computational biology. The underlying objective of MPE research is to better understand the etiology and progression of complex and heterogeneous human diseases with the goal of informing prevention and treatment efforts in population health and clinical medicine. Although MPE research has been commonly applied to investigating breast, lung, and colorectal cancers, its methodology can be used to study most diseases. Recent successes in MPE studies include: (1) the development of new statistical methods to address etiologic heterogeneity; (2) the enhancement of causal inference; (3) the identification of previously unknown exposure-subtype disease associations; and (4) better understanding of the role of lifestyle/behavioral factors on modifying prognosis according to disease subtype. Central challenges to MPE include the relative lack of transdisciplinary experts, educational programs, and forums to discuss issues related to the advancement of the field. To address these challenges, highlight recent successes in the field, and identify new opportunities, a series of MPE meetings have been held at the Dana-Farber Cancer Institute in Boston, MA. Herein, we share the proceedings of the Third International MPE Meeting, held in May 2016 and attended by 150 scientists from 17 countries. Special topics included integration of MPE with immunology and health disparity research. This meeting series will continue to provide an impetus to foster further transdisciplinary integration of divergent scientific fields.

  10. Die Leben Einsteins eine Reise durch die Geschichte der Physik

    CERN Document Server

    Fiami

    2005-01-01

    Jeder kennt die Namen Einstein, Newton oder Galilei. aber was weiss man über sie? Hier ein Porträt Einsteins anhand von sechs Meilensteinen aus der Geschichte der Physik. Einstein tritt auf als Protagonist in verschiedenen Epochen und bei verschiedenen Entdeckungen, die die Welt verändert haben.

  11. Physik für Studenten der Natur- und Technikwissenschaften

    CERN Document Server

    Stroppe, Heribert

    1999-01-01

    Dieses bewährte Lehrbuch vermittelt in kompakter Form einen Überblick über das gesamte physikalische Grundlagenwissen. Die inhaltiche Gliederung nach den Grundmodellen der Physik : Teilchen, Kontinua, Wärme, Felder, Wellen, Quanten, und die didaktische Aufbereitung des Lehrstoffes ermöglichen eine rationelle Wissensaneignung. [...

  12. Gemeinsame Aspekte und Probleme in Physik und Geologie

    Science.gov (United States)

    Watznauer, A.

    Die griechische Naturphilosophie, vor allem Aristoteles, verstand unter Physik die Naturwissenschaft in toto. Die Aufspaltung dieser universellen Naturphilosophie in Fachdisziplinen betrifft sowohl den Gegenstand als auch, daraus abgeleitet, die Methodik der Darstellung. Die Physik, deren Gegenstand seit Galilei die reinen Fälle sind, ist ahistorisch. Die Geologie, die komplexe Systeme untersucht, ist dagegen eine historische Wissenschaft.Translated AbstractCommon Aspects and Problems in Physics and GeologyThe greek philosophers and above all Aristotle thougt in the physics about nature in toto. The splitting of this philosophy of nature into different sciences concerns both their topics and their methods. Since Galilei physics is concerned with pure cases, being an ahistorical science. On the contrary geology examines complex systems, being of historical character.

  13. EC Project 'GUIDELINES ON MPE': proposed qualification and curriculum frameworks and the MPE in nuclear medicine

    Energy Technology Data Exchange (ETDEWEB)

    Caruana, C J, E-mail: carmel.j.caruana@um.edu.mt [EFOMP Representative on the EC ' Guidelines on MPE' Project and Biomedical Physics, Faculty of Health Sciences, University of Malta (Malta)

    2011-09-23

    The objectives of EC project 'Guidelines on Medical Physics Expert' are to provide for improved implementation of the provisions relating to the Medical Physics Expert within Council Directive 97/43/EURATOM and the proposed recast Basic Safety Standards directive. This includes harmonisation of the mission statement for Medical Physics Services as well as the education and training of the MPE. It also includes detailed knowledge-skills-competence inventories for the Medical Physics Expert in each of Diagnostic and Interventional Radiology, Nuclear Medicine and Radiotherapy. This paper presents the proposed Qualification and Curriculum Frameworks and their application to the Medical Physics Expert in Nuclear Medicine.

  14. Distributed caching mechanism for various MPE software services

    CERN Document Server

    Svec, Andrej

    2017-01-01

    The MPE Software Section provides multiple software services to facilitate the testing and the operation of the CERN Accelerator complex. Continuous growth in the number of users and the amount of processed data result in the requirement of high scalability. Our current priority is to move towards a distributed and properly load balanced set of services based on containers. The aim of this project is to implement the generic caching mechanism applicable to our services and chosen architecture. The project will at first require research about the different aspects of distributed caching (persistence, no gc-caching, cache consistency etc.) and the available technologies followed by the implementation of the chosen solution. In order to validate the correctness and performance of the implementation in the last phase of the project it will be required to implement a monitoring layer and integrate it with the current ELK stack.

  15. Der Quantensprung ist keine Hexerei die neue Physik für Einsteiger

    CERN Document Server

    Wolf, Fred Alan

    1986-01-01

    Eine faszinierende Reise von den Grundbegriffen der Physik bis zu den Grenzen der Naturwissenschaft und den menschlichen Vorstellungsvermögens. Dieses Buch verfolgt die Geschichte der Physik von den Beobachtungen der alten Griechen über die Entdeckungen Galileis und Newtons bis zu den erstaunlichen Theorien von Denkern wie Planck, Einstein, Bohr und Born.

  16. Physik für Wissenschaftler und Ingenieure

    CERN Document Server

    Tipler, Paul A; Wagner, Jenny

    2015-01-01

    Das Standardwerk in der rundum erneuerten Auflage – der gesamte Stoff bis zum Bachelor: jetzt auch mit spannenden Einblicken in die aktuelle Forschung! Verständlich, einprägsam, lebendig und die perfekte Prüfungsvorbereitung, mit unzähligen relevanten Rechenbeispielen und Aufgaben – dies ist Tiplers bekannte und beliebte Einführung in die Experimentalphysik. Klar und eingängig führt Tipler den Leser durch die physikalische Begriffs- und Formelwelt illustriert von unzähligen liebevoll gestalteten Farbgrafiken. Studienanfänger – egal, ob sie Physik im Hauptfach studieren oder ob es als Nebenfach auf dem Lehrplan steht – finden hier Schritt für Schritt den klar verständlichen Einstieg in die Physik mittels · Verständlicher Aufarbeitung des Prüfungsstoffes · Zahlreichen prüfungsrelevanten Übungsaufgaben · Anschaulichen Grafiken · Durchgehender Vierfarbigkeit · Übersichtlichem und farbkodiertem Layout · Ausgearbeiteten Beispielaufgaben, vom Text deutlich abgesetzt · Zusammenfa...

  17. Physics for engineers. 15. rev. ed.; Physik fuer Ingenieure

    Energy Technology Data Exchange (ETDEWEB)

    Siebke, W. [Fachhochschule Koblenz (Germany); Simon, G.; Wuttke, W. [comps.] [Westsaechsische Hochschule Zwickau (FH) (Germany); Lindner, H.

    1999-07-01

    This is the 15th, completely revised edition of this standard textbook. Rather than presenting the current state of knowledge in physics, the book aims at presenting the fundamentals of physics in a more up-to-date manner. This applies especially to the pictures and graphical illustrations, which have been replaced or modified so as to meet modern standards. [German] Der LINDNER, Physik fuer Ingenieure, ist ein seit vielen Jahren eingefuehrtes Lehrbuch, das auf Grund seiner weiten Verbreitung bereits zu den Klassikern unter den einfuehrenden Lehrbuechern gezaehlt werden kann. Trotz zahlreicher Verbesserungen in den frueheren Auflagen schien aber nicht zuletzt auf Grund der gestiegenen Anforderungen in den Studiengaengen eine gruendliche Ueberarbeitung des Lehrbuches unumgaenglich: In der neubearbeiteten 15. Auflage wurde der gesamte Stoff einer kritischen Sichtung unterzogen. Viele Kapitel und Abschnitte wurden dabei neu verfasst und den aktuellen Anforderungen angepasst. Zielsetzung war dabei nicht so sehr, den aktuellen Stand der Technik in der Physik darzustellen, sondern die Grundlagen in eine zeitgemaesse Form zu bringen. Die Neubearbeitung betrifft auch das gesamte Bildmaterial. Entbehrliches wurde entfernt, Bewaehrtes beibehalten und viel Neues hinzugefuegt, so dass auch die grafische Gestaltung den veraenderten Anspruechen entspricht. (orig.)

  18. Assessing the function of homologous recombination DNA repair in malignant pleural effusion (MPE) samples.

    Science.gov (United States)

    Patterson, M J; Sutton, R E; Forrest, I; Sharrock, R; Lane, M; Kaufmann, A; O'Donnell, R; Edmondson, R J; Wilson, B T; Curtin, N J

    2014-07-08

    Patients with malignant pleural effusions (MPEs) generally have advanced disease with poor survival and few therapeutic options. Cells within MPEs may be used to stratify patients for targeted therapy. Targeted therapy with poly(ADP ribose) polymerase inhibitors (PARPi) depends on identifying homologous recombination DNA repair (HRR)-defective cancer cells. We aimed to determine the feasibility of assaying HRR status in MPE cells. A total of 15 MPE samples were collected from consenting patients with non-small-cell lung cancer (NSCLC), mesothelioma and ovarian and breast cancer. Primary cultures were confirmed as epithelial by pancytokeratin, and HRR status was determined by the detection of γH2AX and RAD51 foci following a 24-h exposure to rucaparib, by immunofluorescence microscopy. Massively parallel next-generation sequencing of DNA repair genes was performed on cultured MPE cells. From 15 MPE samples, 13 cultures were successfully established, with HRR function successfully determined in 12 cultures. Four samples - three NSCLC and one mesothelioma - were HRR defective and eight samples - one NSCLC, one mesothelioma, one sarcomatoid, one breast and four ovarian cancers - were HRR functional. No mutations in DNA repair genes were associated with HRR status, but there was probable loss of heterozygosity of FANCG, RPA1 and PARP1. HRR function can be successfully detected in MPE cells demonstrating the potential to stratify patients for targeted therapy with PARPi.

  19. Der Kalte Krieg in der Peripherie Griechische Physiker und Atomenergie nach dem Zweiten Weltkrieg

    Science.gov (United States)

    Vlahakis, George N.

    Die vorliegende Arbeit analysiert Ansichten griechischer Physiker zur Atomenergie und deren mögliche Anwendung nach dem Zweiten Weltkrieg, insbesondere während des Kalten Kriegs. Einerseits werden Ansichten von Physik- Professoren griechischer Universitäten präsentiert - beispielsweise von Dimitrios Hondros, der Student von Arnold Sommerfeld und Mitarbeiter von Peter Debye in München war, und andererseits wird die Politik der griechischen Regierung für die Etablierung eines Forschungsinstitutes diskutiert, das der Entwicklung der Atomenergie dienen sollte; ebenfalls wird eine öffentliche Meinungsumfrage zu diesen Thema, die in den Tageszeitungen der damaligen Zeit präsentiert wurde, diskutiert.

  20. Mobile Payload Element (MPE): Concept study for a sample fetching rover for the ESA Lunar Lander Mission

    Science.gov (United States)

    Haarmann, R.; Jaumann, R.; Claasen, F.; Apfelbeck, M.; Klinkner, S.; Richter, L.; Schwendner, J.; Wolf, M.; Hofmann, P.

    2012-12-01

    In late 2010, the DLR Space Administration invited the German industry to submit a proposal for a study about a Mobile Payload Element (MPE), which could be a German national contribution to the ESA Lunar Lander Mission. Several spots in the south polar region of the moon come into consideration as landing site for this mission. All possible spots provide sustained periods of solar illumination, interrupted by darkness periods of several 10 h. The MPE is outlined to be a small, autonomous, innovative vehicle in the 10 kg class for scouting and sampling the environment in the vicinity of the lunar landing site. The novel capabilities of the MPE will be to acquire samples of lunar regolith from surface, subsurface as well as shadowed locations, define their geological context and bring them back to the lander. This will enable access to samples that are not contaminated by the lander descent propulsion system plumes to increase the chances of detecting any indigenous lunar volatiles contained within the samples. Kayser-Threde, as prime industrial contractor for Phase 0/A, has assembled for this study a team of German partners with relevant industrial and institutional competence in space robotics and lunar science. The primary scientific objective of the MPE is to acquire clearly documented samples and to bring them to the lander for analysis with the onboard Lunar Dust Analysis Package (L-DAP) and Lunar Volatile Resources Analysis Package (L-VRAP). Due to the unstable nature of volatiles, which are of particular scientific interest, the MPE design needs to provide a safe storage and transportation of the samples to the lander. The proposed MPE rover concept has a four-wheeled chassis configuration with active suspension, being a compromise between innovation and mass efficiency. The suspension chosen allows a compact stowage of the MPE on the lander as well as precise alignment of the solar generators and instruments. Since therefore no further complex mechanics are

  1. Der Physik-Nobelpreis vor 100 Jahren Eine neue Eigenschaft der Materie

    Science.gov (United States)

    Jacobi, Manfred

    2003-11-01

    Im Jahre 1903 erhielten Henri Becquerel sowie Marie und Pierre Curie den Physik-Nobelpreis für die Entdeckung der Radioaktivität. Schon damals stellte Pierre Curie die Frage nach Nutzen und Gefahr dieser neuen Eigenschaft von Materie. Er war der Überzeugung, dass der Fortschritt letztlich mehr zum Nutzen als zum Schaden der Menschen beitrage.

  2. Die grossen Physiker und ihre Entdeckungen von den fallenden Körpern zu den Quarks

    CERN Document Server

    Segrè, Emilio

    1998-01-01

    Von Galileo Galilei bis zu Richard Feynman und Murray Gell-Mann - von den fallenden Körpern zu den Quarks: Der Physiknobelpreisträger Emilio Segre hat seine ganz persönliche Geschichte der Physik geschrieben. Er erzählt von den großen Gestalten und deren wichtigen Entdeckungen mit großer Anschaulichkeit und Lebendigkeit.

  3. Einsteins annus mirabilis fünf Schriften, die die Welt der Physik revolutionierten

    CERN Document Server

    2001-01-01

    Das Jahr 1905 wird von John Stachel als Einsteins "Annus mirabilis" bezeichnet. Mit fünf Veröffentlichungen revolutionierte der erst 26jährige Patentprüfer das Weltbild der klassischen Physik. Die darin enthaltene Formulierung der speziellen Relativitätstheorie (E = mc ) und die Weiterentwicklung der Quantentheorie machten ihn zu einem der bedeutendsten Wissenschaftler und Denker aller Zeiten.

  4. Physics for physicians; 2. rev. and enl. ed.; Physik fuer Mediziner

    Energy Technology Data Exchange (ETDEWEB)

    Kamke, D. [Bochum Univ. (Germany); Walcher, W. [Marburg Univ. (Germany)

    1994-12-31

    The book is based on lectures read by the authors at medical schools and tailored towards the specific requirements of medical students through a careful selection of subjects, special attention to pertinent medical aspects as well as examples and calculations throwing light on the question of quantity. The book wants to provide insights into the links between physics and some domains of biology and medicine and lead to a better understanding of the magnitudes involved. Being a textbook on physics, the book has adopted the methodology of this science in that results obtained through experimental work are verbally described and closely defined in order to set up rules which would finally permit quantitative determinations to be made on the basis of arithmetic laws. The divisions in this book were made according to a system slightly different from that usually followed. Phenomena of a similar nature are dealt with simultaneously and particular emphasis is placed on an atomistic approach to the problems dealt with. One chapter, ``Physical Principles Underlying the Methods of Medical Imaging`` (X-ray CT, radionuclide procedures, nmr imaging, sonographic), has been added altogether. (orig./HP) [Deutsch] Das Buch ist aus Vorlesungen entstanden, die die Verfasser an ihren Hochschulen speziell fuer angehende Mediziner gehalten haben und die auf deren besondere Beduerfnisse abgestellt waren: durch geeignete Stoffauswahl, durch Betonung medizinischer Aspekte sowie durch Beispiele und Rechenaufgaben, die ans Quantitative heranfuehren. So wil dieses Buch dem Leser Einsicht in die Verknuepfung der Physik mit biologisch-medizinischen Teilbereichen geben und ein Gefuehl fuer die dabei vorkommenden Gruessenordnungen vermitteln. Das Buch ist ein Lehrbuch der Physik, das der Methode der Physik folgt und vom experimentell erarbeiteten und mit Worten beschriebenen Sachverhalt zum exakt definierten Begriff kommt, mit solchen Begriffen Gesetze formuliert, die mit Hilfe der Regeln der

  5. Teknik Pengambilan Keputusan Multi Kriteria Menggunakan Metode BAYES, MPE, CPI dan AHP

    Directory of Open Access Journals (Sweden)

    Abdul Haris Rangkuti

    2011-06-01

    Full Text Available Decision making at every company is something very important and vital. Decision making can be influenced by several aspects, so it can affect the promptness and accuracy of the process, especially when solving any complex, dynamic and less structured problems. Therefore, the combination of multiple criteria concept and an application program of decision-support system is an effective way to generate alternative decisions. The methods used for multiple criteria are: Bayes method, MPE, CPI and the AHP. This article discusses the use of each method, adapted to each problem. The four methods happen to be very effective with the help of the application program of decision support system. Expectantly these methods are able to assist company managements in decision-making. 

  6. Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications.

    Science.gov (United States)

    Balaji, Arunpandian; Jaganathan, Saravana Kumar; Supriyanto, Eko; Muhamad, Ida Idayu; Khudzari, Ahmad Zahran Md

    2015-01-01

    Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera, a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera-induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera-glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants.

  7. Der Begriff der Verständlichkeit in der modernen Physik (1948).

    Science.gov (United States)

    Feyerabend, Paul K

    2016-06-01

    This is a critical transcription of Paul Feyerabend's earliest extant essay "Der Begriff der Verständlichkeit in der modernen Physik" (1948) recovered from the European Forum Alpbach archives. In it, Feyerabend defends positivism as a progressive framework for scientific research in certain stages of scientific development. He argues that in physics visualizability (Anschaulichkeit) and intelligibility (Verständlichkeit) are time-conditioned concepts: what is deemed visualizable in the development of physical theories is relative to a specific historical context and changes over time. He concludes that from time to time the abandonment of visualizability is crucial for progress in physics, as it is conducive to major theory change, illustrating the point on the basis of advances in atomic theory.

  8. Progress in the indirect slumping technology development at MPE for lightweight x-ray optics

    Science.gov (United States)

    Wen, Mingwu; Proserpio, Laura; Breunig, Elias; Friedrich, Peter; Burwitz, Vadim; Madarasz, Emanuel

    2016-10-01

    Large X-ray telescopes for future observatories need to combine a big collecting area, meaning thin mirrors with large diameter, with good angular resolution. Structures have to be stiff enough to guarantee the correct profiles and positioning of such mirrors. Due to the mass limits of the launching rockets, lightweight materials and configurations are required.. The Slumped Glass Optic (SGO) group of the Max-Planck-Institute for Extraterrestrial physics (MPE) is developing the indirect slumping technology to comply with this need. This technique foresees the shaping at high temperature of thin glass foils, originally flat, to Wolter I design X-ray mirror segments, by using suitable moulds. During the thermal cycle inside an electrical oven the glass viscosity is such reduced that it allows its bending onto the mould. So the mould's shape is replicated while still maintaining the original micro-roughness of the glass on the non-contact side that is of fundamental importance for X-ray reflections. This replication process is particularly suitable for the manufacturing of several identical optical elements, which must successively be coated with the necessary reflective layer and then aligned and integrated into supporting structures. Numerous aspects of the technology have been studied in the past, such as the selection of mould and glass materials, and the corresponding optimization of the thermal cycle parameters. During the last year, we focused on different process set-ups. The current results and status of activities will be presented in the paper.

  9. Sinn und Möglichkeiten der Theoretischen Physik. Zum 300. Jahrestag von Newtons Philosophiae Naturalis Principia Mathematica

    Science.gov (United States)

    Rompe, R.; Thiessen, P. A.; Treder, H.-J.

    Die Newtonschen Prinzipien und die aus ihnen gewonnene Erkenntnis der Existenz von Elementarkonstanten nach Planck, Einstein und Bohr erweisen sich zunehmend als tragfähiges Fundament nicht nur der Physik und ihrer Anwendung in der Technik, sondern überhaupt aller exakten Wissenschaften in breitestem Sinne des Wortes.Die physikalisch inhaltliche Klärung der Begriffe erfolgt seit Newton in engem Verbund mit der Entwicklung mathematischer Methoden. Diese Kombination erweist sich weiterhin als produktiv und sichert den Fortschritt der Physik und der exakten Wissenschaften.Wohl alle Probleme, die im Bereich der Technik Bedeutung haben können, lassen sich bei entsprechendem Aufwand bereits mit dem vorhandenen Fundus an Erkenntnissen und Methoden erfolgreich angehen.Der in der Wirklichkeit verankerte Zusammenhang von Gesetz und Zufall erweist sich als eine Manifestation der Dialektik in der Natur. Es gibt keinen absoluten Zufall. Sie kommt in allen Zweigen der Physik, nicht nur in der Thermodynamik und Quantenphysik, zutage, und muß bereits auf dem Niveau der Newtonschen Prinzipien und der Elementarkonstanten behandelt werden.Die theoretische Physik, so wie sie von Newton initiiert worden ist, wurde so angelegt, daß sie alle Seiten der Wirklichkeit, so weit sie in die Kompetenz der Physik fallen, umfaßt. Es besteht darum kein Gegensatz zwischen der klassischen Physik und der Quantenphysik. Es handelt sich lediglich um eine Differenzierung nach den unterschiedlichen physikalischen Inhalten und den angemessenen mathematischen Methoden, die natürlich von der Wahl der Probleme abhängen.Die theoretische Physik stellt eine allgemein zugängliche Zusammenfassung des gesicherten Wissens der Physik dar, das zugleich das Fundament der exakten Wissenschaften ist.Die theoretische Physik ist damit das Mittel der Verständigung innerhalb der Kooperation, die notwendig ist zur Lösung der großen komplexen Aufgaben der Wissenschaft und Technik.Translated AbstractThe Meaning

  10. Geophysical disturbance environment during the NASA/MPE barium release at 5 earth radii on September 21, 1971.

    Science.gov (United States)

    Davis, T. N.; Stanley, G. M.; Boyd, J. S.

    1973-01-01

    The geophysical disturbance environment was quiet during the NASA/MPE barium release at 5 earth radii on September 21, 1971. At the time of the release, the magnetosphere was in the late recovery phase of a principal magnetic storm, the provisional Dst value was -13 gammas, and the local horizontal disturbance at Great Whale River was near zero. Riometer and other observations indicated low-level widespread precipitation of high-energy electrons at Great Whale River before, during, and after the release. Cloudy sky at this station prevented optical observation of aurora. No magnetic or ionospheric effects attributable to the barium release were detected at Great Whale River.

  11. Comparison of NEXRAD Stage III and MPE precipitation products with constraints from high quality and density of raingauge networks in the Upper Guadalupe River Basin, Central Texas

    Science.gov (United States)

    Xie, H.; Wang, X.

    2006-05-01

    NEXRAD's Multisensor Precipitation Estimator (MPE) product replaced the Stage III product started in October 2003 at the West Gulf River Forecast Center (WGRFC) where includes most of the Texas and New Mexico. The MPE is an integrated product of rain gauge, NEXRAD, and satellite (GOES) precipitation estimates. The main objective of MPE is to reduce both areal-mean bias error and local bias error. The overall improved quality of MPE over Stage 3 is evident at the WGRFC. However, so far, there is no quantitative evaluation in a relative long period (one year or more) of a large area. In this study, high quality and density of 50 raingauge networks (6 minutes temporal resolution) in the Upper Guadalupe River Basin, Central Texas are used to evaluate both the Stage III (years 2001 and 2002) and MPE (year 2004) products. In this study, we propose two types of comparison (1) directly compare collocated radar cell and gauge of all rainfall events and (2) only compare collocated radar cell and gauge of homogeneous/uniform rainfall events. To find uniform rainfall events, 6-mintutes raingauge rainfall were used to calculate the correlation coefficient (CC) and coefficient of variation (CV) of a hour among one central gauge and its surrounding gauges (>= 4). For a particular rainfall hour, when CV is 0.5, or CV is <0.1, the rainfall event of this hour is thus selected as a uniform or homogeneous rainfall event. Our preliminary results of CC from all rainfall events and homogeneous rainfall events for year 2004 (MPE) are 0.79 and 0.96, respectively. This indicates an overall good quality of MPE product in comparison with raingauge rainfall, especially for the homogeneous rainfall events. Work is in progress.

  12. Contribution to the search for solar axions in the CAST experiment

    CERN Document Server

    Vafeiadis, Theodoros; Savvidis, Ilias; Liolios, Tassos; Eleftheriadis, Christos

    The CERN Axion Solar Telescope (CAST) is an implementation of the axion helioscope with the highest sensitivity to date. In the present thesis the results of the analysis of one of the Micromegas detectors in CAST (sunrise side) for the 2009 and 2010 data taking periods are presented. A new detector lab has been realized at CERN (162 S-065) with a variable energy calibration system based on an X-ray beam line built at the Max-Planck-Institut für extraterrestrische Physik/Garching (MPE). The purpose of this work is to calibrate for the first time the present and future CAST detectors, in a number of energies and test the efficiency of the software selection criteria.The results of the measurements in the lab were used in the analysis of the data acquired in 2009 and 2010 with the sunrise Micromegas detector of CAST.\

  13. Validating NEXRAD MPE and Stage III precipitation products for uniform rainfall on the Upper Guadalupe River Basin of the Texas Hill Country

    Science.gov (United States)

    Wang, Xianwei; Xie, Hongjie; Sharif, Hatim; Zeitler, Jon

    2008-01-01

    SummaryThis study examines the performance of the Next Generation Weather Radar (NEXRAD) Multisensor Precipitation Estimator (MPE) and Stage III precipitation products, using a high-density rain gauge network located on the Upper Guadalupe River Basin of the Texas Hill Country. As point-area representativeness error of gauge rainfall is a major concern in assessment of radar rainfall estimation, this study develops a new method to automatically select uniform rainfall events based on coefficient of variation criterion of 3 by 3 radar cells. Only gauge observations of those uniform rainfall events are used as ground truth to evaluate radar rainfall estimation. This study proposes a new parameter probability of rain detection (POD) instead of the conditional probability of rain detection (CPOD) commonly used in previous studies to assess the capability that a radar or gauge detects rainfall. Results suggest that: (1) gauge observations of uniform rainfall better represent ground truth of a 4 × 4 km 2 radar cell than non-uniform rainfall; (2) the MPE has higher capability of rain detection than either gauge-only or Stage III; (3) the MPE has much higher linear correlation and lower mean relative difference with gauge measurements than the Stage III does; (4) the Stage III tends to overestimate precipitation (20%), but the MPE tends to underestimate (7%).

  14. Sexl Physik 8 für die 7. und 8. Klasse der allgemein bildenden höheren Schulen (2. Teil)

    CERN Document Server

    Sexl, Roman U; Stadler, Helga; Jakesch, Peter; Sattlberger, Eva

    2013-01-01

    Dieser Band behandelt die Physik des 20. Jahrhunderts (Relativitätstheorie, Quantenmechanik, Kern- und Teilchenphysik, Kosmologie) im philosophisch-historischen Kontext. Wie in jedem Band des Lehrgangs sind übersichtliche Zusammenfassungen, Test- und weiterführende Fragen sowie Rechenbeispiele enthalten.

  15. The world-line. Albert Einstein and modern physics; Die Weltlinie. Albert Einstein und die moderne Physik

    Energy Technology Data Exchange (ETDEWEB)

    Maalampi, Jukka [Jyvaeskylae Univ. (Finland). Dept. of Physics

    2008-07-01

    This book is an entertaining and formula-free presentation of modern physics from the 19th century to present. The life of Albert Einstein and his scientific works are drawn as red fathom through the text. The author explains central terms and results of modern physics in populary-scientific form from the historical perspective. To the reader in humorous form an imagination is mediated how modern physics has been developed. We learn from the exciting effects of the ether, we hear from faraday and magnetic needles, from Maxwell's prediction of the electromagnetic waves, from heinrich Hertz and from the photoelectric effect. Was the Michelson-Morley experiment a measurement success or an unsuccess? Why has Einstein abandoned the ether? How has Einstein in the miraculous year 1905 revolutionated physics and why he has begged Newton for excusement? Exist atoms? What is motion? What is light and what is to be understood under ''now'' and ''here''? Light deviation or non-deviation? How act the tidal forces? And above all: How has Einstein answered these questions. We meet Poincare, Lorentz and Hilbert, Boltzmann and Bohr, Minkowski, Planck, de Broglie, Hubble and Weyl, Gamow, Hahn and Meitner, Kapiza and Landau, Fermi and many other famous scientists. What had Eddington against Chandrasekhar and what had Einstein against black holes? Why should space tourists and dream tourists make holiday not on the Loch Ness but on the safe side of a black hole? Why inveighed Pauli against Einstein? Is the concern with the atomic-bomb formula right? Smeared matter, big bang and cosmic background radiation, gravitational waves and double pulsars, the cosmological constant and the expansion of the universe are further themes, which keep the reader in breath and let no mental vacuum arise. [German] Das Buch ist eine unterhaltsame und formelfreie Darstellung der modernen Physik vom 19. Jahrhundert bis zur Gegenwart. Das Leben Albert Einsteins

  16. Prevention and health promotion from theory to practice: The interprofessional MeMPE Summer University for students of Medicine, Master of Public Health and Epidemiology.

    Science.gov (United States)

    Idler, Nadja; Huber, Johanna; von Mutius, Sabine; Welbergen, Lena; Fischer, Martin R

    2016-01-01

    Objective: During the 2015 summer semester of Munich's Ludwig Maximilian University (LMU) medical school, the pilot project "MeMPE Summer University - An Interprofessional Seminar on Prevention and Health Promotion" was implemented as a compulsory elective subject. In 90 teaching units of 45 minutes each, 20 students from the degree programs of Medicine, Master of Public Health and Master of Science Epidemiology (MeMPE) completed modules in theoretical introduction, scientific project work as well as practical assignments and conference attendance. Methods: The project was evaluated by students using pre- and post-project questionnaires (26 and 57 items, evaluated on a Five-level Likert scale of 1="fully agree" to 5="fully disagree"). The evaluation interviews of the instruction participants were recorded, transcribed and analyzed according to Mayring's qualitative content analysis. Results: Questionnaire response rate was 100 %. In pre/post comparison, the students reported an improvement in factual knowledge (pre median=3.0; post median=2.0; pmotivation to participate in the project again. Conclusion: The MeMPE Summer University can serve as an example of best practice for interprofessional communication of prevention and health-promotion topics in theory and practice. The evaluation results show that the project enjoyed a high level of acceptance among students and instructors, and that it should be conducted in a revised version again in 2016.

  17. Prevention and health promotion from theory to practice: The interprofessional MeMPE Summer University for students of Medicine, Master of Public Health and Epidemiology

    Directory of Open Access Journals (Sweden)

    Idler, Nadja

    2016-11-01

    Full Text Available Objective: During the 2015 summer semester of Munich’s Ludwig Maximilian University (LMU medical school, the pilot project “MeMPE Summer University – An Interprofessional Seminar on Prevention and Health Promotion” was implemented as a compulsory elective subject. In 90 teaching units of 45 minutes each, 20 students from the degree programs of Medicine, Master of Public Health and Master of Science Epidemiology (MeMPE completed modules in theoretical introduction, scientific project work as well as practical assignments and conference attendance.Methods: The project was evaluated by students using pre- and post-project questionnaires (26 and 57 items, evaluated on a Five-level Likert scale of 1=“fully agree” to 5=“fully disagree”. The evaluation interviews of the instruction participants were recorded, transcribed and analyzed according to Mayring’s qualitative content analysis.Results: Questionnaire response rate was 100 %. In pre/post comparison, the students reported an improvement in factual knowledge (pre median=3.0; post median=2.0; p<0.0001, in scientific work (pre median=3.0; post median=1.0; p<0.0001 and in interprofessional work (pre median=2.0; post median=1.0; p=0.024. In 18 interviews, the instructors largely expressed their motivation to participate in the project again.Conclusion: The MeMPE Summer University can serve as an example of best practice for interprofessional communication of prevention and health-promotion topics in theory and practice. The evaluation results show that the project enjoyed a high level of acceptance among students and instructors, and that it should be conducted in a revised version again in 2016.

  18. Elementary particles. Modern physics from the atoms to the standard model; Elementare Teilchen. Moderne Physik von den Atomen bis zum Standard-Modell

    Energy Technology Data Exchange (ETDEWEB)

    Bleck-Neuhaus, Joern [Bremen Univ. (Germany). FB 1 Physik

    2010-07-01

    The actual state of knowledge of nuclear and elementary-particle physics has a fluctuating history of origin, often characterized by shockingly new formations of terms, which until today are for studyings of physics often only under difficulties accessible. This books uses the controverse and at the same time instructive development processes themselves for the access to the difficult new concepts. It makes understandable, how the physical picture of the smallest particles looks today und why it has arised so and not otherwise: From the detection of the existence of the atoms up to the present standard model of elementary-particle physics, in a steady exchange between established theoretical models, confirming and contradicting experimental findings, sometimes controversial new formations of terms, improved experiments etc. - a process, which certainly continues in the future. Guidance of the presentation is an also in the detail reproducible argumentation. Studyings of physics before their B.Sc. examination will get knowledges about subatomar physics, which belong to the genralknowledge of their field. Also for teachings of physics at schools or universities this new presentation might be interesting. [German] Der aktuelle Wissensstand der Kern- und Elementarteilchenphysik hat eine wechselvolle Entstehungsgeschichte, oft gekennzeichnet durch schockierend neue Begriffsbildungen, die sich bis heute den Physik-Studierenden oft nur unter Muehen erschliessen. Dieses Buch nutzt die kontroversen und zugleich lehrreichen Entwicklungsprozesse selber fuer den Zugang zu den schwierigen neuen Konzepten. Es macht verstaendlich, wie das physikalische Bild von den kleinsten Teilchen heute aussieht und warum es so und nicht anders entstanden ist: Vom Nachweis der Existenz der Atome bis zum derzeitigen Standard-Modell der Elementarteilchenphysik, in einem staendigen Wechselspiel zwischen etablierten theoretischen Modellen, bestaetigenden oder widersprechenden experimentellen

  19. New Method to Determine the Range of DVB-H Networks and the Influence of MPE-FEC Rate and Modulation Scheme

    Directory of Open Access Journals (Sweden)

    Gauderis Hugo

    2009-01-01

    Full Text Available Abstract DVB-H networks allow high data rate broadcast access for hand-held terminals. A new method to determine the range of good reception quality of such a DVB-H network will be investigated in this paper. To this end, a new subjective criterion is proposed, based on the viewing experience of the users. This criterion is related to the percentage of valid reception. A comparison with existing criteria, based on measured signal strengths, is also made. The ranges are determined for mobile reception inside a car. The influence of the MPE-FEC rate and the modulation scheme on the range is also investigated, enabling wireless telecom operators to select optimal settings for future networks.

  20. New Method to Determine the Range of DVB-H Networks and the Influence of MPE-FEC Rate and Modulation Scheme

    Directory of Open Access Journals (Sweden)

    David Plets

    2009-01-01

    Full Text Available DVB-H networks allow high data rate broadcast access for hand-held terminals. A new method to determine the range of good reception quality of such a DVB-H network will be investigated in this paper. To this end, a new subjective criterion is proposed, based on the viewing experience of the users. This criterion is related to the percentage of valid reception. A comparison with existing criteria, based on measured signal strengths, is also made. The ranges are determined for mobile reception inside a car. The influence of the MPE-FEC rate and the modulation scheme on the range is also investigated, enabling wireless telecom operators to select optimal settings for future networks.

  1. A consultoria em gestão realizada pelo contabilista como alternativa de redução da mortalidade das MPE

    Directory of Open Access Journals (Sweden)

    Juarez Domingues Carneiro

    2005-03-01

    Full Text Available Este artigo tem por finalidade demonstrar que é possível reduzir a alta taxa de mortalidade das Micro e Pequenas Empresas no Brasil, na ordem de quase 50% nos dois primeiros anos, por meio da consultoria especializada em gestão, realizada por profissionais da contabilidade. O estudo tem como um de seus pilares, o estabelecimento de uma relação entre a Teoria Geral dos Sistemas e o Sistema de Gestão das Micro e Pequenas Empresas (MPE, tendo como seu subsistema principal a Consultoria em Gestão pelo Contabilista. O artigo ao mesmo tempo em que evidencia a presença constante do profissional da contabilidade nas MPE, desde o seu surgimento, também identifica uma série de causas que levam a essa mortalidade, principalmente na área de gestão, trazendo uma proposta de alternativa de redução de tal problemática, por intermédio, especialmente, da formação continuada do profissional da área contábil. This artide aims to show that it is possible to reduce the high mortality rate ofMicro and 5mall Enterprises (M5Es in Brazil, reaching almost 50% in the twofirst years, by means of consultancy, specialized in Gestion, given byaccounting professionals. One of the main fundaments of this study is theestablishment of a relationship between 5ystems General Theory and Gestion5ystem of Micro and 5mall Enterprises having as its most relevant subsystems,the Gestion Consultancy by the Accountant. Besides highlighting the frequentpresence of the Accounting Professional in the M5Es since those were firstcreated, this artide also identities series of causes that lead to theirmortality, mainly in the Gestion Area, bringing an alternative proposal ofreducing such a problem, especially through the continued education of theaccounting area professional.

  2. Vom Fang bis zum Datensatz - hilfreiche Anmerkungen für ein erfolgreiches Sammeln : Bericht über den COLEO-Workshop am 15. März 2003 in der Biologischen Station Urdenbacher Kämpe

    OpenAIRE

    Stöcker, Michael

    2009-01-01

    Wie schon in den vergangenen Jahren fand auch in diesem Jahr wieder ein praxisorientierter Workshop im Anschluss an die COLEO‑ Jahreshauptversammlung in der Urdenbacher Kämpe bei Monheim statt. Im Mittelpunkt des diesjährigen Workshops standen Fragen, Tipps und Hilfestellungen aus der praktischen Coleopterologie. Intention und Ziel war es, jungen Kollegen und Neueinsteigern Hilfen in diesen allgemeinen und grundlegenden Fragen geben.

  3. Auf dem Weg zur digitalen Fakultät - moderne IT Infrastruktur am Beispiel des Physik-Departments der TU München

    Science.gov (United States)

    Homolka, Josef

    Der Geschäftsbetrieb einer Universität ist durch zunehmende Digitalisierung und Nutzung elektronischer Medien gekennzeichnet. Die Einführung immer leistungsfähigerer zentraler IT-Systeme führt zu einer komplexen Vielfalt heterogener Benutzer- und Administrationsschnittstellen. Zur Schaffung einer umfassenden benutzerfreundlichen und nahtlosen IT-Infrastruktur ist die Beteiligung aller organisatorischen Einheiten und Ebenen erforderlich. Am Physik-Departement der Technischen Universität München wurden unter Integration eigener Ressourcen mit zentralen Ressourcen, die im Rahmen des IntegraTUM Projektes entwickelt und bereitgestellt wurden, existierende Dienste weiterentwickelt und neue Angebote aufgebaut. Das System, bestehend aus den Komponenten Netzwerk, Arbeitsplatzrechner, Serverinfrastruktur, E-Mail-Service, WWWDienst, Datenhaltung und Software wurde für die Nutzerkreise Studenten und Mitarbeiter im Hinblick auf Anwenderfreundlichkeit und nahtlosen Zugriff optimiert.

  4. Posicionamento estratégico de MPE'S com base na inovação através do modelo Hélice Tríplice

    Directory of Open Access Journals (Sweden)

    Dusan Schreiber

    Full Text Available A globalização dos mercados, os avanços da ciência e da tecnologia, estimulou o surgimento de novos nichos de mercado, com consumidores mais exigentes, e, também, o aumento da competitividade entre empresas (ORTIZ, 2003. Nesse panorama, destacam-se as micro e pequenas empresas - MPE's, que se responsabilizam por parcela relevante de geração de oportunidades de emprego e de renda no país. No entanto,estudos apontam para a fragilidade técnica e produtiva das MPE'sque se reflete em índices mais elevados de encerramento de operações e de inadimplência de obrigações sociais e tributárias (SEBRAE, 2009. Esses agentes econômicos, por vezes menos preparados para competir, mas essenciais para o sistema econômico e social dos países, foram contemplados com políticas públicas, voltadas para o estímulo ao empreendedorismo, priorizando a capacitação em gestão e métodos de produção (CASSIOLATO & LASTRES, 2001. Dentre elas destacam-se a constituição de redes colaborativas de MPE's, a capacitação de seus gestores e equipes operacionais, além da disponibilização de acesso ao conhecimento técnico, com vistas a subsidiar a atividade de inovação de produtos e processos (MATTOS et al., 2009. Com o objetivo de otimizar a alocação de recursos públicos para o referido fim, os agentes governamentais optam pela adoção do modelo de Hélice Tríplice, por meio do qual o governo media a interação entre a academia e as empresas e fomenta o compartilhamento da infra-estrutura universitária, dos conhecimentos, métodos e técnicas, desde a gestão até a operação. O objetivo deste trabalho visa evidenciar as características do posicionamento estratégico de empresas de pequeno porte, que participam de duas redes de cooperação, atuantes na região sul do país, com destaque para o processo de concepção de estratégias individuais e coletivas construídas com base em programas de capacitação em inovação, de produtos e

  5. Theoretical physics 3. Classical field theory. On electrodynamics, non-Abelian gauge theories, and gravitation. 3. ed.; Theoretische Physik 3. Klassische Feldtheorie. Von Elektrodynamik, nicht-Abelschen Eichtheorien und Gravitation

    Energy Technology Data Exchange (ETDEWEB)

    Scheck, Florian [Mainz Univ. (Germany). Fachbereich Physik

    2010-07-01

    Stringent presentation of field theory, mediates the connection from the classicalelectrodynamics up to modern gauge theories. The compact presentation is ideal for the bachelor study. New chapter on general relativity theory. Deepens the learned by numerous application from laser physic, metamaterials and different more. Theoretical physics 3. Classical field theory. On electrodynamics, non-Abelian, and gravitation is the third of five volumes on theoretical physics by professor Scheck. The cycle theoretical physics comprehends: Volume 1: Mechanics. From Newtons law to the deterministic chaos. Volume 2: Nonrelativistic quantum theory. From the hydrogen atom to the many-particle systems. Volume 3: Classical field theory. From the electrodynamics to the gauge theories. Volume 5: From the laws of thermodynamics to the quantum statistics. This textbook mediates modern theoretical physics in string presentation illustrated by many examples. It contains numerous problems with solution hints ore exemplary, complete solutions. The third edition was revised in many single topics, especially the chapter on general relativity theory was supplemented by an extensive analysis of the Schwarzschild solution. [German] Stringente Darstellung der Feldtheorie, vermittelt den Zusammenhang von der klassischen Elektrodynamik bis zu modernen Eichtheorien. Die kompakte Darstellung ist ideal fuer das Bachelor-Studium. Neues Kapitel zur Allgemeinen Relativitaetstheorie. Vertieft das Erlernte durch zahlreiche Anwendungsbeispiele aus Laserphysik, Metamaterialien uvm. Theoretische Physik 3. Klassische Feldtheorie. Von Elektrodynamik, nicht-Abelschen Eichtheorien und Gravitation ist der dritte von fuenf Baenden zur Theoretischen Physik von Professor Scheck. Der Zyklus Theoretische Physik umfasst: Band 1: Mechanik. Von den Newtonschen Gesetzen zum deterministischen Chaos. Band 2: Nichtrelativistische Quantentheorie. Vom Wasserstoffatom zu den Vielteilchensystemen. Band 3: Klassische Feldtheorie

  6. X ray observations of late-type stars using the ROSAT all-sky survey

    Science.gov (United States)

    Linsky, Jeffrey L.; Fleming, Thomas A.

    1992-03-01

    The ROSAT mission made the first x ray survey of the entire sky using an imaging detector. Although ROSAT is a joint NASA/German project and involves direct American participation during its second phase of pointed observations, the all-sky survey remains the sole property of the German investigators. NASA grant represented the first use of ROSAT data analysis funds to support direct American participation in the ROSAT all-sky survey. The project involved a collaborative agreement between the Joint Institute for Laboratory Astrophysics (JILA) and the Max-Planck-Institut fur Extraterrestrische Physik (MPE) where JILA supplied MPE with a post-doctoral research associate with experience in the field of stellar (coronal) x ray emission to work within their ROSAT group. In return, members of the cool star research group at JILA were given the opportunity to collaborate on projects involving ROSAT all-sky survey data. Both sides have benefitted (and still benefit) from this arrangement since MPE suffers from a shortage of researchers who are interested in x ray emission from 'normal' stars and white dwarfs. MPE has also drawn upon experience in optical identification of x ray sources from the Einstein Extended Medium Sensitivity Survey in planning their own identification strategies for the ROSAT all-sky survey. The JILA cool stars group has benefitted since access to all-sky survey data has expanded the scope of their already extensive research programs involving multiwavelength observations of late-type stars. ROSAT was successfully launched on 1 June 1990 and conducted the bulk of the survey from 30 July 1990 to 25 January 1991. Data gaps in the survey have subsequently been made up. At the time of this writing (February 1992), the survey data have been processed once with the Standard Analysis Software System (SASS). A second processing will soon begin with improvements made to the SASS to correct errors and bugs found while carrying out scientific projects with data

  7. (and Sound) of SiMPE

    DEFF Research Database (Denmark)

    Erkut, Cumhur; Jylhä, Antti; Serafin, Stefania

    As contemporary smartphones become ubiquitous, their nature changes from mere function to a tool for self- expression, creativity, or play. Mobile application development embraces this change, as evidenced by the popularity and profits of sound and music applications and games in various applicat......As contemporary smartphones become ubiquitous, their nature changes from mere function to a tool for self- expression, creativity, or play. Mobile application development embraces this change, as evidenced by the popularity and profits of sound and music applications and games in various......) programming and interaction design into university curricula. In this paper, we provide an account of our own development and teaching experience. We highlight the outcomes, which are exploratory applications challenging the state-of-the-art in mobile application development based on non-speech sound...

  8. First light of the ESO Laser Guide Star Facility

    Science.gov (United States)

    Bonaccini Calia, D.; Allaert, E.; Alvarez, J. L.; Araujo Hauck, C.; Avila, G.; Bendek, E.; Buzzoni, B.; Comin, M.; Cullum, M.; Davies, R.; Dimmler, M.; Guidolin, I.; Hackenberg, W.; Hippler, S.; Kellner, S.; van Kesteren, A.; Koch, F.; Neumann, U.; Ott, T.; Popovic, D.; Pedichini, F.; Quattri, M.; Quentin, J.; Rabien, S.; Silber, A.; Tapia, M.

    2006-06-01

    Two teams of scientists and engineers at Max Planck Institut fuer Extraterrestrische Physik and at the European Southern Observatory have joined forces to design, build and install the Laser Guide Star Facility for the VLT. The Laser Guide Star Facility has now been completed and installed on the VLT Yepun telescope at Cerro Paranal. In this paper we report on the first light and first results from the Commissioning of the LGSF.

  9. Physik gestern und heute Das Eiskalorimeter

    Science.gov (United States)

    Heering, P.

    2003-07-01

    Kalorimetrische Messungen gehören heute zum experimentellen Standardrepertoire im Bereich der Thermodynamik und der physikalischen Chemie. Das erste Gerät für derartige Messungen entwickelten Ende des 18. Jahrhunderts die französischen Wissenschaftler Antoine Laurent Lavoisier und Pierre Simon de Laplace.

  10. Physik 50 Experimente : 9. - 13. Schulstufe

    CERN Document Server

    Neumann, Susanne

    2015-01-01

    Dieses Buch richtet sich sowohl an Kinder und Jugendliche, die auf der Suche nach spannenden Experimenten sind, als auch an Lehrkräfte. Um den didaktischen Anspruch zu erfüllen, werden insbesonders Experimente ausgewählt, die zum Nachdenken anregen, da Phänomene gezeigt werden, die mit den Alltagsvorstellungen oft nicht vereinbar sind. Diese Beobachtungen sollen Kinder und Jugendliche nicht nur verblüffen, sondern auch motivieren nach einer Erklärung zu suchen und ihre Alltagsvorstellungen in Frage zu stellen.

  11. Effects of thermotherapy plus intracavitary chemotherapy in the treatment of MPE caused by different lung cancer%深部热、化疗对不同病理类型肺癌所致恶性胸腔积液的疗效观察

    Institute of Scientific and Technical Information of China (English)

    徐舒; 赵永心; 龙德

    2012-01-01

    目的 观察深部热、化疗对肺癌引起的恶性胸腔积液(Malignant pleural effusion,MPE)的疗效及其与病理类型的相关性.方法 将晚期肺癌合并MPE患者根据病理类型分为腺癌组(28例)和鳞癌组(25例),先行胸腔穿刺充分引流后给予博来霉素50mg+甘露聚糖肽60mg腔内注射,同时局部热疗.腔内注药1次/周,热疗2~3次/周,2周为一个疗程,一个疗程后给予最佳支持治疗,监测胸水控制情况及KPS评分改善、毒副反应.结果 两组间近期有效率(CR+PR)%无统计学差异(鳞癌组64.0%,腺癌组82.1%,P=0.212);有效控制时间腺癌组优于鳞癌组(58.1±11.9d vs 45.8±11.5d,P=0.003);两组间Karnofsky评分改善及毒副反应发生率无显著性差异.结论 深部热、化疗对晚期肺癌MPE有较好的控制作用,其中腺癌患者较鳞癌患者获得更长的有效控制时间;腺癌组KPS改善也有优于鳞癌组的趋势.%Objective To evaluate the curative effect of thermotherapy plus intracavitary chemotherapy treating MPE in different lung cancer patients, as well as the toxic and adverse reaction and the influence on Karnofsky performance status. Methods Totally 53 advanced lung cancer patients with MPE were divided into two groups according to pathology, namely adenocarcinoma group and SQCA group. After puncture and drainage of thoracic cavity, intracavitary chemotherapy was subsequently performed by intracavitary administration of Bleomy-cin and Mannatide once a week. At the same time, thermotherapy was followed twice or thrice a week. After a two -week treatment all patients were given best supporting therapy, and then hydrothorax, Karnofsky performance status and toxic and adverse reactions were monitored. Results There was no significant difference in the recent response rates( 64. 0% of SQCA group vs. 82. 1% of adenocarcinoma group,P = 0. 212 ), Karnofsky grade improvements and side - effects occurrences between two groups. However, adenocarcinoma group

  12. Schwerpunkt – Physik - Solarthermie : Physik und Technik der Solarthermie in Afrika

    OpenAIRE

    Schäfer, Daniel

    2008-01-01

    Energie, die wichtigste aller Ressourcen, bildet die Grundlage jeder menschlichen Unternehmung. Die massenhafte und großflächige Verfügbarkeit billiger Energie ist die Grundlage für den Wohlstand der technisch entwickelten Welt. Verfügbarkeit, Wirtschaftlichkeit und Nachhaltigkeit von Energiequellen sind drei Facetten eines komplexen Problems, dem sich die Weltgemeinschaft zu Beginn des 21. Jahrhundert gegenüber sieht: der Energiefrage. Die Gestalt der Welt von morgen wird entsche...

  13. Some applications of nanometer scale structures for current and future X-ray space research

    DEFF Research Database (Denmark)

    Christensen, Finn Erland; Abdali, S; Frederiksen, P K;

    1994-01-01

    Institute in collaboration with the FOM Institute for Plasma Physics, Nieuwegein, the Max-Planck-Institut für Extraterrestrische Physik, Aussenstelle Berlin, the Space Research Institute, Russian Academy of Sciences, the Smithsonian Astrophysical Observatory, Ovonics Synthetic Materials Company and Lawrence...... Livermore National Laboratory. These examples include : 1. the application of multilayered Si crystals for simultaneous spectroscopy in two energy bands one centred around the SK-emission near 2.45 keV and the other below the CK absorption edge at 0.284 keV; 2. the use of in-depth graded period multilayer...

  14. Odyssee im Zeptoraum eine Reise in die Physik des LHC

    CERN Document Server

    Giudice, Gian Francesco

    2010-01-01

    Der Band lädt Leser ein, die Teilchenphysik mit den Augen eines Insiders zu betrachten, dadurch bieten sich neue Einblicke in die Welt der Teilchen und ihrer Wechselwirkungen. Aufschlussreich und unterhaltsam thematisieren die Autoren die Geschichte des Large Hadron Collider (LHC) und erläutern die mit dem LHC verknüpften wissenschaftlichen Fragen: Existiert das mysteriöse Higgs-Teilchen wirklich? Erstreckt sich der Raum in zusätzliche Dimensionen? Das Buch verhilft dazu, die Entdeckungen der kommenden Jahre mitzuverfolgen und nachzuvollziehen.

  15. Big Bang 2 Physik : Schülerbuch

    CERN Document Server

    Apolin, Martin

    2016-01-01

    Physiaklisches Wissen aufbereitet in leicht verständlicher Sprache ; ausgehend von kompetenzorientierten Fragen zu interessanten Antworten ; spannende Bezüge zum Alltag mit Themen aus Sport, Biologie und Medizin.

  16. Medical physics 2013. Abstracts; Medizinische Physik 2013. Abstractband

    Energy Technology Data Exchange (ETDEWEB)

    Treuer, Harald (ed.) [Koeln Univ. (Germany). Klinik fuer Stereotaxie und Funktionelle Neurochirurgie

    2013-07-01

    The proceedings of the medical physics conference 2013 include abstract of lectures and poster sessions concerning the following issues: Tele-therapy - application systems, nuclear medicine and molecular imaging, neuromodulation, hearing and technical support, basic dosimetry, NMR imaging -CEST (chemical exchange saturation transfer), medical robotics, magnetic particle imaging, audiology, radiation protection, phase contrast - innovative concepts, particle therapy, brachytherapy, computerized tomography, quantity assurance, hybrid imaging techniques, diffusion and lung NMR imaging, image processing - visualization, cardiac and abdominal NMR imaging.

  17. Light Dawns on Dark Gamma-ray Bursts

    Science.gov (United States)

    2010-12-01

    journal Astronomy & Astrophysics on 16 December 2010 The team is composed of: J. Greiner (Max-Planck-Institut für extraterrestrische Physik [MPE], Germany), T. Krühler (MPE, Universe Cluster, Technische Universität München), S. Klose (Thüringer Landessternwarte, Germany), P. Afonso (MPE), C. Clemens (MPE), R. Filgas (MPE), D.H. Hartmann (Clemson University, USA), A. Küpcü Yoldaş¸ (University of Cambridge, UK), M. Nardini (MPE), F. Olivares E. (MPE), A. Rau (MPE), A. Rossi (Thüringer Landessternwarte, Germany), P. Schady (MPE), and A. Updike (Clemson University, USA) ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

  18. XIPE: the X-ray imaging polarimetry explorer

    Science.gov (United States)

    Soffitta, Paolo; Barcons, Xavier; Bellazzini, Ronaldo; Braga, João; Costa, Enrico; Fraser, George W.; Gburek, Szymon; Huovelin, Juhani; Matt, Giorgio; Pearce, Mark; Poutanen, Juri; Reglero, Victor; Santangelo, Andrea; Sunyaev, Rashid A.; Tagliaferri, Gianpiero; Weisskopf, Martin; Aloisio, Roberto; Amato, Elena; Attiná, Primo; Axelsson, Magnus; Baldini, Luca; Basso, Stefano; Bianchi, Stefano; Blasi, Pasquale; Bregeon, Johan; Brez, Alessandro; Bucciantini, Niccoló; Burderi, Luciano; Burwitz, Vadim; Casella, Piergiorgio; Churazov, Eugene; Civitani, Marta; Covino, Stefano; Curado da Silva, Rui Miguel; Cusumano, Giancarlo; Dadina, Mauro; D'Amico, Flavio; De Rosa, Alessandra; Di Cosimo, Sergio; Di Persio, Giuseppe; Di Salvo, Tiziana; Dovciak, Michal; Elsner, Ronald; Eyles, Chris J.; Fabian, Andrew C.; Fabiani, Sergio; Feng, Hua; Giarrusso, Salvatore; Goosmann, René W.; Grandi, Paola; Grosso, Nicolas; Israel, Gianluca; Jackson, Miranda; Kaaret, Philip; Karas, Vladimir; Kuss, Michael; Lai, Dong; Rosa, Giovanni La; Larsson, Josefin; Larsson, Stefan; Latronico, Luca; Maggio, Antonio; Maia, Jorge; Marin, Frédéric; Massai, Marco Maria; Mineo, Teresa; Minuti, Massimo; Moretti, Elena; Muleri, Fabio; O'Dell, Stephen L.; Pareschi, Giovanni; Peres, Giovanni; Pesce, Melissa; Petrucci, Pierre-Olivier; Pinchera, Michele; Porquet, Delphine; Ramsey, Brian; Rea, Nanda; Reale, Fabio; Rodrigo, Juana Maria; Różańska, Agata; Rubini, Alda; Rudawy, Pawel; Ryde, Felix; Salvati, Marco; de Santiago, Valdivino Alexandre; Sazonov, Sergey; Sgró, Carmelo; Silver, Eric; Spandre, Gloria; Spiga, Daniele; Stella, Luigi; Tamagawa, Toru; Tamborra, Francesco; Tavecchio, Fabrizio; Teixeira Dias, Teresa; van Adelsberg, Matthew; Wu, Kinwah; Zane, Silvia

    2013-12-01

    View of 14.7 arcmin × 14.7 arcmin. The spectral resolution is 20 % at 6 keV and the time resolution is 8 μs. The imaging capabilities of the JET-X optics and of the GPD have been demonstrated by a recent calibration campaign at PANTER X-ray test facility of the Max-Planck-Institut für extraterrestrische Physik (MPE, Germany). XIPE takes advantage of a low-earth equatorial orbit with Malindi as down-link station and of a Mission Operation Center (MOC) at INPE (Brazil). The data policy is organized with a Core Program that comprises three months of Science Verification Phase and 25 % of net observing time in the following 2 years. A competitive Guest Observer program covers the remaining 75 % of the net observing time.

  19. XIPE the X-Ray Imaging Polarimetry Explorer

    Science.gov (United States)

    Soffitta, Paolo; Barcons, Xavier; Bellazzini, Ronaldo; Braga, Joao; Costa, Enrico; Fraser, George W.; Gburek, Szymon; Huovelin, Juhani; Matt, Giorgio; Pearce, Mark; hide

    2013-01-01

    .7 arcmin 14.7 arcmin. The spectral resolution is 20 at 6 keV and the time resolution is 8 s. The imaging capabilities of the JET-X optics and of the GPD have been demonstrated by a recent calibration campaign at PANTER X-ray test facility of the Max-Planck-Institut fr extraterrestrische Physik (MPE, Germany). XIPE takes advantage of a low-earth equatorial orbit with Malindi as down-link station and of a Mission Operation Center (MOC) at INPE (Brazil). The data policy is organized with a Core Program that comprises three months of Science Verification Phase and 25 of net observing time in the following 2 years. A competitive Guest Observer program covers the remaining 75 of the net observing time.

  20. The ERIS adaptive optics system

    Science.gov (United States)

    Riccardi, A.; Esposito, S.; Agapito, G.; Antichi, J.; Biliotti, V.; Blain, C.; Briguglio, R.; Busoni, L.; Carbonaro, L.; Di Rico, G.; Giordano, C.; Pinna, E.; Puglisi, A.; Spanò, P.; Xompero, M.; Baruffolo, A.; Kasper, M.; Egner, S.; Suàrez Valles, M.; Soenke, C.; Downing, M.; Reyes, J.

    2016-07-01

    ERIS is the new AO instrument for VLT-UT4 led by a Consortium of Max-Planck Institut fuer Extraterrestrische Physik, UK-ATC, ETH-Zurich, ESO and INAF. The ERIS AO system provides NGS mode to deliver high contrast correction and LGS mode to extend high Strehl performance to large sky coverage. The AO module includes NGS and LGS wavefront sensors and, with VLT-AOF Deformable Secondary Mirror and Laser Facility, will provide AO correction to the high resolution imager NIX (1-5um) and the IFU spectrograph SPIFFIER (1-2.5um). In this paper we present the preliminary design of the ERIS AO system and the estimated correction performance.

  1. The NGS Pyramid wavefront sensor for ERIS

    Science.gov (United States)

    Riccardi, A.; Antichi, J.; Quirós-Pacheco, F.; Esposito, S.; Carbonaro, L.; Agapito, G.; Biliotti, V.; Briguglio, R.; Di Rico, G.; Dolci, M.; Ferruzzi, D.; Pinna, E.; Puglisi, A.; Xompero, M.; Marchetti, E.; Fedrigo, E.; Le Louarn, M.; Conzelmann, R.; Delabre, B.; Amico, P.; Hubin, N.

    2014-07-01

    ERIS is the new Single Conjugate Adaptive Optics (AO) instrument for VLT in construction at ESO with the collaboration of Max-Planck Institut fuer Extraterrestrische Physik, ETH-Institute for Astronomy and INAF - Osservatorio Astrofisico di Arcetri. The ERIS AO system relies on a 40×40 sub-aperture Pyramid Wavefront Sensor (PWFS) for two operating modes: a pure Natural Guide Star high-order sensing for high Strehl and contrast correction and a low-order visible sensing in support of the Laser Guide Star AO mode. In this paper we present in detail the preliminary design of the ERIS PWFS that is developed under the responsibility of INAF-Osservatorio Astrofisico di Arcetri in collaboration with ESO.

  2. The ERIS Adaptive Optics System

    CERN Document Server

    Riccardi, A; Agapito, G; Antichi, J; Biliotti, V; Blain, C; Briguglio, R; Busoni, L; Carbonaro, L; Di Rico, G; Giordano, C; Pinna, E; Puglisi, A; Spanò, P; Xompero, M; Baruffolo, A; Kasper, M; Egner, S; Valles, M Suàrez; Soenke, C; Downing, M; Reyes, J

    2016-01-01

    ERIS is the new AO instrument for VLT-UT4 led by a Consortium of Max-Planck Institut fuer Extraterrestrische Physik, UK-ATC, ETH-Zurich, ESO and INAF. The ERIS AO system provides NGS mode to deliver high contrast correction and LGS mode to extend high Strehl performance to large sky coverage. The AO module includes NGS and LGS wavefront sensors and, with VLT-AOF Deformable Secondary Mirror and Laser Facility, will provide AO correction to the high resolution imager NIX (1-5um) and the IFU spectrograph SPIFFIER (1-2.5um). In this paper we present the preliminary design of the ERIS AO system and the estimated correction performance.

  3. Hvad er vejledningsfaglighed - og er den værd at kæmpe for?

    DEFF Research Database (Denmark)

    Nielsen, Grethe Fogh

    2014-01-01

    I en tid, hvor vejlederprofessionen er under pres fra flere sider, og hvor man kan se, at det økonomiske system sætter en dagsorden, der reducerer vejledning til noget, der kan klares med en chat eller i en kollektiv sammenhæng i klasseværelset, er det væsentligt at tydeliggøre, hvad vejledningsf......I en tid, hvor vejlederprofessionen er under pres fra flere sider, og hvor man kan se, at det økonomiske system sætter en dagsorden, der reducerer vejledning til noget, der kan klares med en chat eller i en kollektiv sammenhæng i klasseværelset, er det væsentligt at tydeliggøre, hvad...

  4. 49 CFR 212.213 - Motive power and equipment (MP&E) inspector.

    Science.gov (United States)

    2010-10-01

    ...), Safety Glazing Standards (49 CFR part 223), Locomotive Safety Standards (49 CFR part 229), Safety Appliance Standards (49 CFR part 231), and Power Brake Standards (49 CFR part 232), to make reports of those... Standards, Locomotive Safety Standards, Safety Appliance Standards and Power Brake Standards. (3)...

  5. DEGRO 2009. Radiation oncology - medical physics - radiation biology. Abstracts; DEGRO 2009. Radioonkologie - Medizinische Physik - Strahlenbiologie. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-06-15

    The special volume of the journal covers the abstracts of the DEGRO 2009 meeting on radiation oncology, medical physics, and radiation biology, covering the following topics: seldom diseases, gastrointestinal tumors, radiation reactions and radiation protection, medical care and science, central nervous system, medical physics, the non-parvicellular lung carcinomas, ear-nose-and throat, target-oriented radiotherapy plus ''X'', radio-oncology - young academics, lymphomas, mammary glands, modern radiotherapy, life quality and palliative radiotherapy, radiotherapy of the prostate carcinoma, imaging for planning and therapy, the digital documentation in clinics and practical experiences, NMR imaging and tomography, hadrons - actual status in Germany, urinal tract oncology, radiotoxicity.

  6. Physik gestern und heute Das Rastertunnelmikroskop - von der Störstellenanalyse zum Nanowerkzeug

    Science.gov (United States)

    Hennig, Jochen

    2004-09-01

    Mit dem Rastertunnelmikroskop steht der Forschung ein Instrument zur atomgenauen Oberflächenuntersuchung zur Verfügung, das seit seiner Entwicklung 1982 bereits eine wechselhafte Geschichte hinter sich hat.

  7. Calculation of hadronic transition amplitudes in charm physics; Berechnung hadronischer Uebergangsamplituden in der Charm-Physik

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Christoph

    2011-09-23

    Transitions of charmed hadrons are of significant importance, since they provide possibilities to extract the CKM matrix elements V{sub cd} and V{sub cs} from experimental data as well as interesting channels to search for new physics effects. However, quarks are bound in hadrons, and it is necessary to describe this effect in a reliable way, to study the underlying flavour dynamics. For this, one has to use nonperturbative tools, to determine the corresponding transition amplitudes. The results of such calculations can furthermore be of use, to test the predictions of QCD and to contribute to a deeper understanding of the structure of hadrons. In this thesis two topics are investigated using the method of QCD light-cone sum rules (LCSRs). The first topic consists in the form factors of the semileptonic decays D {yields} {pi}l{nu}{sub l} and D {yields} Kl{nu}{sub l}, for which new results are calculated using up-to-date input values. Since LCSRs are not applicable in the whole range of kinematics, they are extrapolated by the use of appropriate parametrisations and the results agree well with experimental data. The second topic are the transitions of charmed baryons to a nucleon. Here the corresponding transition form factors and in addition the hadronic {lambda}{sub c}D{sup (*)}N and {sigma}{sub c}D{sup (*)}N coupling constants are calculated - the latter by the consideration of double dispersion relations. These coupling constants are of special interest for the description of hadronic interactions, like open charm production in proton-antiprotoncollisions. Furthermore there appears the problem, that both parity states of a baryon contribute to the considered functional representation, for which a consistent way to separate them is presented. (orig.)

  8. C. F. v. Weizsaecker. Physicist, philosopher, visionary; C. F. v. Weizsaecker. Physiker, Philosoph, Visionaer

    Energy Technology Data Exchange (ETDEWEB)

    Goernitz, Thomas

    2012-11-01

    The 20th century with its political, social, and scientific aspects bundles itself in the life of Carl Friedrich v. Weizsaecker. As comprehensive thinker of the presence he led natural science, philosophy, and spirituality to a unity. In the public the grandson of last in Germany enobled minster and brother of the senior federal president achieved by his engagement for peace and disarmament a global effect. Competently and understandably his visionary and prospective physical ideas and his philosophical considerations are explained by his long standing coworker and close confident.

  9. Physics and radiology for nursing staff. Physik und Strahlenkunde fuer Krankenpflegeberufe

    Energy Technology Data Exchange (ETDEWEB)

    Goretzki, G.

    1984-01-01

    As nurses working in hospitals and surgeries as well as other assistants regularly operate technical equipment, it is essential to explain the physical basics in a form which is comprehensible to them. The author has managed to give a very clear portrayal of each area of physics with close reference to its application in medicine, partly with the use of simplified models. His portrayal extends from the make-up of the material to atomic and nuclear physics and covers mechanics, heat and electricity theory, optics and acoustics. The explanation is completed by sections on radiography and radiation protection.

  10. Physics and radiology for the nursing professions. 4. rev. ed. Physik und Strahlenkunde fuer Krankenpflegeberufe

    Energy Technology Data Exchange (ETDEWEB)

    Goretzki, G. (Gemeinschaftspraxis Radiologie/Nuklearmedizin Dres. Stuckenholz, Ritter, Urban, Goretzki, Bielefeld (Germany))

    1991-01-01

    The development of new methods and equipment also brings about in medicine continuous changes. To be mentioned here in the field of diagnotics is nuclear magnetic resonance imaging. The amendment of the Radiation Protection Ordinance of 1989 also made it necessary to revise appropriate chapters of this book. (orig.) With 119 figs.

  11. The Most Distant Mature Galaxy Cluster - Young, but surprisingly grown-up

    Science.gov (United States)

    2011-03-01

    information This research was presented in a paper, "A mature cluster with X-ray emission at z = 2.07", by R. Gobat et al., published in the journal Astronomy & Astrophysics. The team is composed of R. Gobat (Laboratoire AIM-Paris-Saclay, France), E. Daddi (AIM-Paris), M. Onodera (ETH Zürich, Switzerland), A. Finoguenov (Max-Planck-Institut für extraterrestrische Physik [MPE], Garching, Germany), A. Renzini (INAF-Osservatorio Astronomico di Padova), N. Arimoto (National Astronomical Observatory of Japan), R. Bouwens (Lick Observatory, Santa Cruz, USA), M. Brusa (MPE), R.-R. Chary (California Institute of Technology, USA), A. Cimatti (Università di Bologna, Italy), M. Dickinson (NOAO, Tucson, USA), X. Kong (University of Science and Technology of China), and M.Mignoli (INAF - Osservatorio Astronomico di Bologna, Italy). ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 15 countries: Austria, Belgium, Brazil, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the

  12. Report on the ESO/MPA/MPE/Excellence Cluster/LMU and TUM Munich Joint Conference ''Discs in Galaxies''

    Science.gov (United States)

    Ellis, R.

    2016-09-01

    The annual Munich Joint Astronomy Conference brought together observers and theorists studying the full range of cosmic environments and epochs where discs play a role in shaping the structural assembly history of galaxies. Considerable progress is being made in interpreting the past history of the Milky Way and Andromeda through massive stellar imaging and spectroscopic campaigns. This is being augmented with interferometric studies of gaseous discs in nearby galaxies with exquisite angular resolution. Integral field spectrographs are providing resolved data for star-forming and quiescent galaxies to redshifts of three. This explosion of new data is being interpreted with high resolution numerical simulations in order to understand the physical processes which govern the stability, formation and disruption of early discs, and how star formation is regulated in the context of various feedback processes. Selected highlights of the progress reported at the conference are presented.

  13. Sharpest Ever VLT Images at NAOS-CONICA "First Light"

    Science.gov (United States)

    2001-12-01

    demonstration of the value of international collaboration. ESO and its partner institutes and companies in France and Germany have worked a long time towards this goal - with the first, extremely promising results, we shall soon be able to offer a new and fully tuned instrument to our wide research community." The NAOS adaptive optics corrector was built, under an ESO contract, by Office National d'Etudes et de Recherches Aérospatiales (ONERA) , Laboratoire d'Astrophysique de Grenoble (LAOG) and the DESPA and DASGAL laboratories of the Observatoire de Paris in France, in collaboration with ESO. The CONICA infra-red camera was built, under an ESO contract, by the Max-Planck-Institut für Astronomie (MPIA) (Heidelberg) and the Max-Planck Institut für Extraterrestrische Physik (MPE) (Garching) in Germany, in collaboration with ESO. The present event happens less than four weeks after "First Fringes" were achieved for the VLT Interferometer (VLTI) with two of the 8.2-m Unit Telescopes. No wonder that a spirit of great enthusiasm reigns at Paranal! Information for the media: ESO is producing a Video News Release ( ESO Video News Reel No. 13 ) with sequences from the NAOS-CONICA "First Light" event at Paranal, a computer animation illustrating the principle of adaptive optics in NAOS-CONICA, as well as the first astronomical images obtained. In addition to the usual distribution, this VNR will also be transmitted via satellite Friday 7 December 2001 from 09:00 to 09:15 CET (10:00 to 10:15 UT) on "Europe by Satellite" . These video images may be used free of charge by broadcasters. Satellite details, the script and the shotlist will be on-line from 6 December on the ESA TV Service Website http://television.esa.int. Also a pre-view Real Video Stream of the video news release will be available as of that date from this URL. Video Clip 07/01 : Various video scenes related to the NAOS-CONICA "First Light" Event ( ESO Video News Reel No. 13 ). PR Photo 33a/01 : NAOS-CONICA "First light

  14. The physicist. Max Planck and the decay of the world; Der Physiker. Max Planck und das Zerfallen der Welt

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Ernst Peter

    2010-06-15

    The live of the physicist Max Planck was as exciting, conflicting, and rich on catastrophes as the epoch, in which he lived. Ernst Peter Fischer draws in this fascinatingly told biography the eventful history of the Nobel-price bearer and illustrates simultaneously the unique attainment of Planck, the quantum theory of whom not only revolted the science but also changed fundamentally our picture of the world.

  15. Revolutions in twentieth-century physics; Einfuehrung in die Physik des 20. Jahrhunderts. Relativitaetstheorie, Quantenmechanik, Elementarteilchenphysik und Kosmologie

    Energy Technology Data Exchange (ETDEWEB)

    Griffiths, David J. [Reed College, Portland, OR (United States). Howard-Vollum-Professur fuer Naturwissenschaften

    2015-07-01

    Relativity theory, quantum mechanics, elementary-particle physics, and cosmology are the four pillars of modern physics. The life in the 21th century is without them no more conceivable: The special relativity theory renewed our understanding of space and time, on the laws of quantum mechanics are based countless everyday objects like transistors, computer chips, and mobile telephones; in particle accelerators we study the components oof matter, and with telescopes we take an ever deeper look in the past of the universe. Taking reference books to these themes at hand, one is overwhelmed by the plethora and complexity of the mathematical formulas. This book of the renowned professor of physics David J. Griffiths id refreshingly different. By means of many illustrative examples and entertaining stories it introducts to the themes and helps the reader also without a large mathematical apparatus to a fundamental understanding of that, about which Einstein, Schroedinger, Heisenberg, and Hubble actually thought and spoke. In each chapter numerous, pedagogically selected examples are completely worked out, in order to fill the matter with life. Moreover the text contains a manifold of problems, which allow the reader to deepen his knowledge and apply immediately. Griffith's ''Revolution in Twentieth Century Physics'' appeals not only to pupils and future studyings of natural sciences, who want to get an appetite for what lies ahead, but also to interested readers, which have already heared in the media from quarks and quanta, the curved space-time, Albert Einstein, and the big bang and now want to understandably know what is at stake in all the excitement.

  16. 46. Annual meeting of the German Society for Medical Physics. Abstracts; 46. Jahrestagung der Deutschen Gesellschaft fuer Medizinische Physik. Abstractband

    Energy Technology Data Exchange (ETDEWEB)

    Fiebich, Martin [Technische Hochschule Mittelhessen, Giessen (Germany). Inst. fuer Medizinische Physik und Strahlenschutz; Zink, Klemens (ed.) [Technische Hochschule Mittelhessen, Giessen (Germany). Inst. fuer Medizinische Physik und Strahlenschutz; Universitaetsklinikum Giessen-Marburg, Marburg (Germany). Klinik fuer Strahlentherapie und Radioonkologie

    2015-07-01

    The abstracts volume of the 46th annual meeting of the German Society for Medical Physics includes abstracts on the following issues: audiology; particle therapy: dosimetric and biological aspects; functional and molecular imaging; computerized tomography; dosimetry: 2D dosimetry and clinical dosimetry; MR imaging: cardio and lungs imaging; quality assurance in radiation therapy; brachytherapy/IORT; irradiation planning; functional and molecular imaging: methodic principles; dosimetry: dosimetric base data and Monte Carlo; adaptive and guided radiation therapy; irradiation planning; laser accelerated protons; brachytherapy/IORT: dosimetry; particle therapy: irradiation planning and imaging; stereotaxis and radiosurgery; radiation protection; dosimetry: detectors and small photon fields; MRT and MRS - neuroimaging; particle therapy: in vivo verification.

  17. The imaging properties of the Gas Pixel Detector as a focal plane polarimeter

    CERN Document Server

    Fabiani, S; Del Monte, E; Muleri, F; Soffitta, P; Rubini, A; Bellazzini, R; Brez, A; de Ruvo, L; Minuti, M; Pinchera, M; Sgrò, C; Spandre, G; Spiga, D; Tagliaferri, G; Pareschi, G; Basso, S; Citterio, O; Burwitz, V; Burkert, W; Menz, B; Hartner, G

    2014-01-01

    X-rays are particularly suited to probe the physics of extreme objects. However, despite the enormous improvements of X-ray Astronomy in imaging, spectroscopy and timing, polarimetry remains largely unexplored. We propose the photoelectric polarimeter Gas Pixel Detector (GPD) as an instrument candidate to fill the gap of more than thirty years of lack of measurements. The GPD, in the focus of a telescope, will increase the sensitivity of orders of magnitude. Moreover, since it can measure the energy, the position, the arrival time and the polarization angle of every single photon, allows to perform polarimetry of subsets of data singled out from the spectrum, the light curve or the image of source. The GPD has an intrinsic very fine imaging capability and in this work we report on the calibration campaign carried out in 2012 at the PANTER X-ray test facility of the Max-Planck-Institut f\\"ur extraterrestrische Physik of Garching (Germany) in which, for the first time, we coupled it to a JET-X optics module wit...

  18. Introduction to Mining the Sky: Proceedings of the MPA/ESO/MPE Workshop Held at Garching, Germany, July 31 - August 4, 2000: Mining 101

    Science.gov (United States)

    Wright, Edward L.

    For more than one hundred years, astronomers have had access to large data sets. A typical photographic plate contains 100 Megabytes of data. But these old analog optical ROMs, accessible only by traveling to a central depository, have been replaced by digital data accessible over a world-wide network from desktop workstations everywhere. New techniques for collecting data, storing and cataloging data, simulating data, and analyzing data are needed to extract a mother lode of scientific insight from the flood of available bits.

  19. SINFONI Opens with Upbeat Chords

    Science.gov (United States)

    2004-08-01

    Dutch Institutes and ESO who have worked on the development of SINFONI for nearly 7 years. The work on SINFONI at Paranal included successful commissioning in June 2004 of the Adaptive Optics Module built by ESO, during which exceptional test images were obtained of the main-belt asteroid (22) Kalliope and its moon. Moreover, the ability was demonstrated to correct the atmospheric turbulence by means of even very faint "guide" objects (magnitude 17.5), crucial for the observation of astronomical objects in many parts of the sky. SPIFFI - SPectrometer for Infrared Faint Field Imaging - was developed at the Max Planck Institute for Extraterrestrische Physik (MPE) in Garching (Germany), in a collaboration with the Nederlandse Onderzoekschool Voor Astronomie (NOVA) in Leiden and the Netherlands Foundation for Research in Astronomy (ASTRON), and ESO. PR Photo 24a/04: SINFONI Adaptive Optics Module at VLT Yepun (June 2004) PR Photo 24b/04: SINFONI at VLT Yepun, now fully assembled (July 2004) PR Photo 24c/04: "First Light" image from the SINFONI Adaptive Optics Module PR Photo 24d/04: AO-corrected Image of a 17.5-magnitude Star PR Photo 24e/04: SINFONI undergoing Balancing and Flexure Tests at VLT Yepun PR Photo 24f/04: SINFONI "First Light" Spectrum of HD 130163 PR Photo 24g/04: Members of the SINFONI Adaptive Optics Module Commissioning Team PR Photo 24h/04: Members of the SPIFFI Commissioning Team PR Photo 24i/04: The Principle of Integral Field Spectroscopy (IFS) PR Photo 24j/04: The Orbital Motion of Linus around (22) Kalliope PR Photo 24k/04: SINFONI Observations of the Galactic Centre Region PR Photo 24l/04: SINFONI Observations of the Circinus Galaxy PR Photo 24m/04: SINFONI Observations of the AGN Galaxy NGC 7469 PR Photo 24n/04: SINFONI Observations of NGC 6240 PR Photo 24o/04: SINFONI Observations of the Young Starforming Galaxies BX 404/405 PR Video Clip 07/04: The Orbital Motion of Linus around (22) Kalliope SINFONI: A powerful and complex instrument ESO PR Photo

  20. Surfing a Black Hole

    Science.gov (United States)

    2002-10-01

    and how these supermassive black holes formed and why almost every massive galaxy appears to contain one. The formation of central black holes and that of their host galaxies themselves increasingly appear to be just one problem and the same. Indeed, one of the outstanding challenges for the VLT to solve in the next few years. There is also little doubt that coming interferometric observations with instruments at the VLT Interferometer (VLTI) and the Large Binocular Telescope (LBT) will also result in another giant leap within this exciting field of research. Andreas Eckart is optimistic: "Perhaps it will even be possible with X-ray and radio observations in the next few years to directly demonstrate the existence of the event horizon." More information The information presented in this Press Release is based on a research article ("Seeing a Star Orbit around the Supermassive Black Hole at the centre of the Milky Way" by Rainer Schödel et al.) that appears in the research journal "Nature" on October 17, 2002. Notes [1]: This press release is issued in coordination between ESO and the Max-Planck-Institute for Extraterrestrial Physics (MPE) in Garching, Germany. A German version is available at http://www.mpg.de/pri02/pri0287.htm. [2]: The team consists of Rainer Schödel, Thomas Ott, Reinhard Genzel, Reiner Hofmann and Matt Lehnert (Max-Planck-Institut für extraterrestrische Physik, Garching, Germany), Andreas Eckart and Nelly Mouawad (Physikalisches Institut, Universität zu Köln, Cologne, Germany), Tal Alexander (The Weizmann Institute of Science, Rehovot, Israel), Mark J. Reid (Harvard-Smithsonian Center for Astrophysics, Cambridge, Mass., USA), Rainer Lenzen and Markus Hartung (Max-Planck-Institut für Astronomie, Heidelberg, Germany), François Lacombe, Daniel Rouan, Eric Gendron and Gérard Rousset (Observatoire de Paris - Section de Meudon, France), Anne-Marie Lagrange (Laboratoire d'Astrophysique, Observatoire de Grenoble, France), Wolfgang Brandner, Nancy

  1. THE IMAGING PROPERTIES OF THE GAS PIXEL DETECTOR AS A FOCAL PLANE POLARIMETER

    Energy Technology Data Exchange (ETDEWEB)

    Fabiani, S.; Costa, E.; Del Monte, E.; Muleri, F.; Soffitta, P.; Rubini, A. [INAF-IAPS, via del Fosso del Cavaliere 100, I-00133 Roma (Italy); Bellazzini, R.; Brez, A.; De Ruvo, L.; Minuti, M.; Pinchera, M.; Sgró, C.; Spandre, G. [INFN Sezione di Pisa, Largo B. Pontecorvo, 3, I-56127 Pisa (Italy); Spiga, D.; Tagliaferri, G.; Pareschi, G.; Basso, S.; Citterio, O. [INAF-Osservatorio Astronomico di Brera, via Brera 28, I-20121 Milano (Italy); Burwitz, V.; Burkert, W., E-mail: sergio.fabiani@iaps.inaf.it [Max-Planck-Institut für extraterrestrische Physik, Gautinger Str. 45, D-82061 Neuired (Germany); and others

    2014-06-01

    X-rays are particularly suited to probing the physics of extreme objects. However, despite the enormous improvements of X-ray astronomy in imaging, spectroscopy, and timing, polarimetry remains largely unexplored. We propose the photoelectric polarimeter Gas Pixel Detector (GPD) as a candidate instrument to fill the gap created by more than 30 yr without measurements. The GPD, in the focus of a telescope, will increase the sensitivity of orders of magnitude. Moreover, since it can measure the energy, the position, the arrival time, and the polarization angle of every single photon, it allows us to perform polarimetry of subsets of data singled out from the spectrum, the light curve, or an image of the source. The GPD has an intrinsic, very fine imaging capability, and in this work we report on the calibration campaign carried out in 2012 at the PANTER X-ray testing facility of the Max-Planck-Institut für extraterrestrische Physik of Garching (Germany) in which, for the first time, we coupled it with a JET-X optics module with a focal length of 3.5 m and an angular resolution of 18 arcsec at 4.5 keV. This configuration was proposed in 2012 aboard the X-ray Imaging Polarimetry Explorer (XIPE) in response to the ESA call for a small mission. We derived the imaging and polarimetric performance for extended sources like pulsar wind nebulae and supernova remnants as case studies for the XIPE configuration and also discuss possible improvements by coupling the detector with advanced optics that have a finer angular resolution and larger effective areas to study extended objects with more detail.

  2. The Imaging Properties of the Gas Pixel Detector as a Focal Plane Polarimeter

    Science.gov (United States)

    Fabiani, S.; Costa, E.; Del Monte, E.; Muleri, F.; Soffitta, P.; Rubini, A.; Bellazzini, R.; Brez, A.; de Ruvo, L.; Minuti, M.; Pinchera, M.; Sgró, C.; Spandre, G.; Spiga, D.; Tagliaferri, G.; Pareschi, G.; Basso, S.; Citterio, O.; Burwitz, V.; Burkert, W.; Menz, B.; Hartner, G.

    2014-06-01

    X-rays are particularly suited to probing the physics of extreme objects. However, despite the enormous improvements of X-ray astronomy in imaging, spectroscopy, and timing, polarimetry remains largely unexplored. We propose the photoelectric polarimeter Gas Pixel Detector (GPD) as a candidate instrument to fill the gap created by more than 30 yr without measurements. The GPD, in the focus of a telescope, will increase the sensitivity of orders of magnitude. Moreover, since it can measure the energy, the position, the arrival time, and the polarization angle of every single photon, it allows us to perform polarimetry of subsets of data singled out from the spectrum, the light curve, or an image of the source. The GPD has an intrinsic, very fine imaging capability, and in this work we report on the calibration campaign carried out in 2012 at the PANTER X-ray testing facility of the Max-Planck-Institut für extraterrestrische Physik of Garching (Germany) in which, for the first time, we coupled it with a JET-X optics module with a focal length of 3.5 m and an angular resolution of 18 arcsec at 4.5 keV. This configuration was proposed in 2012 aboard the X-ray Imaging Polarimetry Explorer (XIPE) in response to the ESA call for a small mission. We derived the imaging and polarimetric performance for extended sources like pulsar wind nebulae and supernova remnants as case studies for the XIPE configuration and also discuss possible improvements by coupling the detector with advanced optics that have a finer angular resolution and larger effective areas to study extended objects with more detail.

  3. Fascinating physics. An illustrated expedition from the universe until the world of the elementary particles; Faszinierende Physik. Ein bebildeter Streifzug vom Universum bis in die Welt der Elementarteilchen

    Energy Technology Data Exchange (ETDEWEB)

    Bahr, Benjamin [Albert-Einstein-Institut (Max-Planck Institut fuer Gravitationsphysik), Golm (Germany); Riebe, Kristin [Potsdam Univ. (Germany). Leibniz-Institut fuer Astrophysik; Resag, Joerg

    2013-07-01

    ''Fascinating physics'' is a picturesque expedition through 140 themes of classical and modern physics. On each one double-page to the reader is thereby offered a compact access in each one theme: From the aurora until the black hole, from the particle accelerator until the GPS system, from the curved space-time until the supersymmetry, from the oscillating dipole until Foucault's pendulum - a large variety of themes is taken up and carefully explained. Thereby the special strength of the book lies in the clear language and the explanations get along mostly without formulas - accompanied by breathtaking pictures, which lead the beauty of our world in front of the eyes.

  4. Sexl Physik 7 für die 7. und 8. Klasse der allgemein bildenden höheren Schulen (1. Teil)

    CERN Document Server

    Sexl, Roman U; Stadler, Helga; Jakesch, Peter; Sattlberger, Eva

    2012-01-01

    Die Schwerpunkte dieses Bandes sind die Erarbeitung der Themen Optik, Atombau und Elektrodynamik über einen historisch-philosophischen Zugang. Wie in jedem Band des Lehrgangs sind übersichtliche Zusammenfassungen, Test- und weiterführende Fragen sowie Rechenbeispiele enthalten.

  5. Energy - the problem and the transition in physics, technics, and environment; Energie - das Problem und die Wende in Physik, Technik und Umwelt

    Energy Technology Data Exchange (ETDEWEB)

    Stierstadt, Klaus

    2015-11-01

    What existed first, the energy problem or the energy transition? For the clarification of this question the author gives a survey about the actual situation of our energy demand and the means and ways to its satisfaction. The reader learns to know the function of numerous energy transformers, from the wind mill via the automobile motor until the solar cell. The advantages and disadvantages of the different transformers are explained, just so their efficiencies and cost as well as the physical natural laws, which they must obey. A perpetuum mobile doesn't exist, but indeed an almost inexhaustible energy source, the sun, which can meet many thousandfold our demand, if we use it intelligently. Who has read this book can go confidently in each discussion about the energy problem and the energy transition.

  6. From physics to metaphysics. A sociological reconstruction of the interpretation problem of the quantum theory; Von der Physik zur Metaphysik. Eine soziologische Rekonstruktion des Deutungsproblems der Quantentheorie

    Energy Technology Data Exchange (ETDEWEB)

    Vogd, Werner

    2014-07-01

    The quantum theory represents one of the most fastidious and successful theory projects of the history of mankind. It is one, if not the universal theory of physics. The history of its interpretation and the discussion affects however by far more than only the field of theoretical physics. Such theory approach destroys ontological certainty. It calls the observer in question, and it lets us anticipate, what is to be expected, if we are employed in other fields with complex phenomena, which are infected with the observer problematics. As transclassical physics the quantum theory is so to say built on ''worlds without ground'' and disappoints by this the hope to be able to set themselves free from mind questions by physics or mathematics. Homologuously to the top forms of mystic reflexion the discussion about the interpretation of quantum physics can mediate an idea, what the mystery of the conditioned coproduction of system and environment - reflexion and world - can mean for us and possibly help us to become homelike in worlds without grounds. Hereby it becomes clear, that highly driven theory, which solves itself in its abstractions in a high degree from the live-worldly reality, stands not in contradiction to the possibility of knowledge of the world. On the contrary, at first a theory creation sufficiently elaborated and endowed with own internally conditioned consistency constraints represents the condition for the possibility of reflexion and gain of knowledge.

  7. Five-dimensional theoretical physics. Statements on the nature of the gravitation and the electromagnetism; Fuenfdimensionale Theoretische Physik. Thesen zur Natur der Gravitation und des Elektromagnetismus

    Energy Technology Data Exchange (ETDEWEB)

    Peters, Norbert

    2011-07-01

    This book contains a generalization of Newton' s gravitation theory to wave mechanics, as well as a five-dimensionalunification of these wave mechanics with Maxwell's electrodynamics and the derivation of a five-dimensional relativity theory. At the end of the essay stands a five-dimensional generally covariant variational principle, from which all above mentioned theories can be derived. In the framework of the generalization to this variational principle the foundations of the classical theories and the general relativity theory are discussed.

  8. In the depths of the particle world. Searched for: New physics beyond the Higgs; In den Tiefen der Teilchenwelt. Gesucht: Eine neue Physik jenseits des Higgs

    Energy Technology Data Exchange (ETDEWEB)

    Beckers, Mike (comp.)

    2015-07-01

    The following topics are dealt with: Particle accelerators of the future, expected surprises from the LHC, the reality in quantum field theory, expected LHC results in string theory, the internal structure of the quarks, supersymmetry in the crisis, the search for ultralight particles, new physics with neutrinos, the still unknown properties of the neutrinos, the proton radius, the internal structure of the neutron. (HSI)

  9. Restart of the LHC. New physics. The particle physics behind the world machine illustratively explained; Neustart des LHC. Neue Physik. Die Teilchenphysik hinter der Weltmaschine anschaulich erklaert

    Energy Technology Data Exchange (ETDEWEB)

    Knochel, Alexander

    2016-07-01

    The following topics are dealt with: The ascertainment of scientific virgin territory by means of the LHC ar CERN, the study of actual questions of cosmology and astrophysics like dark matter and dark energy by means of the LHC, the presently existing anomalies in the data with regards to new phenomena together with statistical methods for the correct estimation of such observations, the supplement of other experiments for the LHC experiments, the Higgs boson, supersymmetry, higher dimensions, the study of quantum gravity in accelerator experiments with regards to the string theory. (HSI)

  10. In the depths of the particle world. Searched for: New physics beyond the Higgs; In den Tiefen der Teilchenwelt. Gesucht: Eine neue Physik jenseits des Higgs

    Energy Technology Data Exchange (ETDEWEB)

    Koenneker, Carsten; Beckers, Mike (comps.)

    2016-07-01

    The following topics are dealt with: Future particle accelerators, possible surprising results from LHC experiments, the reality in quantum field theory, possibilities for studies of te string theory by means of the LHC, the structure of quarks, supersymmetry in crisis, the search for ultralight particles, new physics with neutrinos, the application of neutrino properties for cosmology, the paradoxon of the proton radius, the internal structure of the neutron. (HSI)

  11. From the depths of the universe to the microcosm. An expedition through modern physics; Von den Tiefen des Alls in den Mikrokosmos. Ein Streifzug durch die moderne Physik

    Energy Technology Data Exchange (ETDEWEB)

    Povh, Bogdan [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany)

    2017-02-01

    The following topics are dealt with: Gravitation from the beginning of astronomy until dark energy, atoms from indivisible balls until quantum-mechanical systems, atomic nuclei, the earth planet, quarks and leptons, the expanding universe. (HSI)

  12. Shape theory. Functional connections of information, energy, and temperature in phasics and physiology; Gestalttheorie. Funktionelle Zusammenhaenge von Information, Energie und Temperatur in Physik und Physiologie

    Energy Technology Data Exchange (ETDEWEB)

    Wengel, Claus

    2012-11-01

    Starting from the phenomenon of the information input and the information output system in the central nervous system, which was conceived in physiology, as well as from the phenomenon of the disturbance oc consciousness, which was in neuropsychiatry psychopathometrically and by this quantitatively determinable, the author was occupied by the general question: How systems can be described, which possess and exchange temperature, energy, and information? A connection of thermodynamics and information theory was found and presented in this work. It came to the redefinition of several quantities, which can be applied both in mathematical physics and in mathematical physiology. First the negentropy was defined in fact as first partial derivation of the total information on the absolute temperature. Further definitions follow: That of the shape (measured in bit.J/K), that of the action (measured in bit.J), as well that of the structure (measured in bit.J/K{sup 2}). Functional connections of information, energy, and temperature as well as of further quantities became recognizable and were written. Mathematical physics were thereby enriched, also by conservation laws. But also mathematical physiology was extended. Here diseases like the inflammatory diseases catatonia, epilepsy, tumor, vegetative dystonies, anorexy, dementia, as well as the phenomenon vitality and the phenomenon sleeping were comprehended by formulas. As consequences resulted proposals resulted for the prophylaxis and for the therapy and for the design of a live-preserving and live-elongating way of life. These proposals are in the sections, which treat the diseases, detailedly listed and derived. Furthermore a first law of psychodynamics was formulated - in analogy to the first law of thermodynamics.

  13. Tutorium quantum mechanics. By an experienced tutor for students of physics and mathematics. 2. ed.; Tutorium Quantenmechanik. Von einem erfahrenen Tutor - fuer Physik- und Mathematikstudenten

    Energy Technology Data Exchange (ETDEWEB)

    Schwindt, Jan-Markus

    2016-07-01

    The focus of this book lies on the general postulates of quantum mechanics (QM), their interpretation, their fundamental terms, and their mathematical formulation. The first and most comprehensive part of the book is dedicated to this thematics. In the second part an imported special case is treated: The QM of the wave functions in one, two, and three spatial dimensions under the condition, that the Hamiltonian operator consists only of the kinetic term and a timely independent potential. The most important examples hereby are the harmonic oscillator and the hydrogen atom. Also the scattering theory is discussed in this framework. The third part comprehends further themes, which belong to the canonical matter of a QM course: Combination of spin and angular momentum, QM with electromagnetism, perturbation theory, and systems with several particles. Rounded off is the whole by a short explanation of the path-integral term and by the relativistic theory of the electron (Dirac equation). Target group of this book are students of physics, who hear QM in the framework of theoretical physics. By the axiomatically deductive approach and the detailed discussion of the mathematical background it is also very well suited for mathematicians, who want to come to an understanding of QM in the subsidiary subject or in their leisure time.

  14. The night of the physicists. Heisenberg, Hahn, Weizsaecker, and the German bomb; Die Nacht der Physiker. Heisenberg, Hahn, Weizsaecker und die deutsche Bombe

    Energy Technology Data Exchange (ETDEWEB)

    Schirach, Richard von

    2014-07-01

    Finally the German atomic physicists around Heisenberg, von Weizsaecker, and Hahn worked on their ''uranium machine'' in a Swabian beer-cellar - and took themselves for the world elite of nuclear research. In imprisonment they heared from the dropping of the Hiroshima bomb - a shock. Richard von Schirach shows the hindered ''fathers of the German atomic bomb'' in close-up, their eagerness, their hybris, their true importance, and their attempts to give after the war a new interpretation of their own role. A book, which raises in the sense of Duerrenmatt the question for the responsibility of science.

  15. Towards an explanation of the world. Milestones of physics and astrophysics; Auf dem Weg zur Erklaerung der Welt. Meilensteine der Physik und Astrophysik

    Energy Technology Data Exchange (ETDEWEB)

    Hosemann, J. Peter

    2014-07-01

    The present book wants to be helpful to explain and summarize the present status of knowledge in the main fields of research for the today unified picture of the world. Very extensively nuclear and particle physics is explained. They are the foundation of cosmology, to which the second half of the book is dedicated. To the chapter about the expansion of the universe and bout the Friedman equations follow chapters on the cosmic red shift and about distances in the universe. Discussed are the big bang and the cosmic inflation as well as dark matter, dark energy, and the accelerated expansion of the universe. Exciting are the aspects of nucleosynthesis, by which the stellar dust is generated, of which we men consist. The final chapter is dedicated to the earth, its development, and the origins of life.

  16. Armouring facility? Nuclear-weapon and reactor reseach at the Kaiser-Wilhelm Institute for Physics; Eine Waffenschmiede? Kernwaffen- und Reaktorforschung am Kaiser-Wilhelm-Institut fuer Physik

    Energy Technology Data Exchange (ETDEWEB)

    Hachtmann, R. (ed.); Walker, M.

    2005-07-01

    The Kaiser Wilhelm Institute for Physics is best known as the place where Werner Heisenberg worked on nuclear weapons for Hitler. Although this is essentially true, there is more to the story. At the start of World War II this institute was taken over by the German Army Ordnance to be the central, but not exclusive site for a research project into the economic and military applications of nuclear fission. The Army physicist Kurt Diebner was installed in the institute as its commissarial director. Heisenberg was affiliated with the institute as an advisor at first, and became the director in 1942. Heisenberg and his colleagues, including in particular Karl-Heinz Hoecker, Carl Friedrich von Weizsaecker, and Karl Wirtz, worked on nuclear reactors and isotope separation with the clear knowledge that these were two different paths to atomic bombs [Atombomben]. However, they were clearly ambivalent about what they were doing. New documents recently returned from Russian archives shed new light on this work and the scientists' motivations. (orig.)

  17. Upright in the storm of time. The physicist James Franck 1882-1964; Aufrecht im Sturm der Zeit. Der Physiker James Franck 1882-1964

    Energy Technology Data Exchange (ETDEWEB)

    Lemmerich, J.

    2007-07-01

    For the 125th birth day of James Franck in the year 2007 for the first time a scientific biography is presented. Born in Hamburg Franck dedicated himself to the exploration of the atom. Together with Gustav Hertz he succeeded in exciting of bound electrons by collision, whereby the atomic model of Bohr was confirmed. For this both got the Nobel price for the year 1925. Starting from 1921 Franck founded together with Max Born and Robert Pohl the world-wide reputation of Goettingen as a center of physical research. 1933 Franck resigned because of protest against the antisemitic policy of the Nazis and imigrated to the USA. There he dedicated himself to the exploration of the foundation of the photosynthesis. To the request to contribute the the construction of the atomic bomb the Hitler opponent not denied, but wrote after the German capitulation the Franck report in May 1945, in which he described impressively the arguments against the application of the bomb and warned for a nuclear armament race. Although he was because of the great crime of the Nazi regime very critical against the Germans soon after the war he stood up - very to the indignation of his friend Einstein - for the reconcilement and visited Germany and his friends there still several times. 1964 he died at a visit in Goettingen.

  18. Limiting value definition in radiation protection physics, legislation and toxicology. Fundamentals, contrasts, perspectives; Grenzwertbildung im Strahlenschutz. Physik, Recht, Toxikologie. Grundlagen, Kontraste, Perspektiven

    Energy Technology Data Exchange (ETDEWEB)

    Smeddinck, Ulrich; Koenig, Claudia (eds.)

    2016-07-01

    The volume is the documentation of an ENTRIA workshop discussion on limiting value definition in radiation protection including the following contributions: Introduction in radiation protection -fundamentals concepts of limiting values, heterogeneity; evaluation standards for dose in radiation protection in the context of final repository search; definition of limiting values in toxicology; public participation to limiting value definition - a perspective for the radiation protection regulation; actual developments in radiation protection.

  19. Quantum mechanics. Textbook for students of physics, mathematics and physical chemistry. Quantenmechanik. Studienbuch fuer Studierende der Physik, Mathematik und Physikalischen Chemie

    Energy Technology Data Exchange (ETDEWEB)

    Grawert, G. (Marburg Univ. (Germany, F.R.). Fachbereich 13 - Physik)

    1989-01-01

    The aim of the textbook now present in fifth edition is the representation of the fundamental physical concepts of the theory of quantum mechanics. It is confined to the nonrelativistic quantum mechanics; however also themes are treated which are in an extended form important just for quantum field theory up to the modern development. (orig.) With 22 figs.

  20. Tutorium quantum mechanics. By an experienced tutor for students of physics and mathematics; Tutorium Quantenmechanik. Von einem erfahrenen Tutor - fuer Physik- und Mathematikstudenten

    Energy Technology Data Exchange (ETDEWEB)

    Schwindt, Jan-Markus

    2013-07-01

    Tutorium quantum mechanics is a book, written by an experiences tutor for all, who finally want to understand from the beginning physics and mathematics of quantum mechanics. The book treats the matter of the corresponding course in the framework of theoretical physics. The main topic lies in this book on the general postulates of quantum mechanics and the clarification of the fundamental terms. What is precisely a Hilbert space? What is an Hermitian operator? A tensor product? An entangled state? To what extend wave functions are vectors? The postulates raise until today also many questions concerning their interpretation. This is discussed in a separate chapter. This book is structured in such a way that each step and each new term is explained by means of simple examples. The author attaches great importance to the clarity of the applied mathematics - something, what he and many students in other textbooks had hitherto to miss. By this main topic is also very well suited for mathematicists, who want to deal with the issue. In the examination preparation the book is especially well suited for the clarification of terms and questions of understanding. The questions of understanding and the exercise problems interspersed in the text with solutions support additionally the learning and the preparation for examination.

  1. ROSAT Discovers Unique, Distant Cluster of Galaxies

    Science.gov (United States)

    1995-06-01

    Brightest X-ray Cluster Acts as Strong Gravitational Lens Based on exciting new data obtained with the ROSAT X-ray satellite and a ground-based telescope at the ESO La Silla Observatory, a team of European astronomers [2] has just discovered a very distant cluster of galaxies with unique properties. It emits the strongest X-ray emission of any cluster ever observed by ROSAT and is accompanied by two extraordinarily luminous arcs that represent the gravitationally deflected images of even more distant objects. The combination of these unusual characteristics makes this cluster, now known as RXJ1347.5-1145, a most interesting object for further cosmological studies. DISCOVERY AND FOLLOW-UP OBSERVATIONS This strange cluster of galaxies was discovered during the All Sky Survey with the ROSAT X-ray satellite as a moderately intense X-ray source in the constellation of Virgo. It could not be identified with any already known object and additional ground-based observations were therefore soon after performed with the Max-Planck-Society/ESO 2.2-metre telescope at the La Silla observatory in Chile. These observations took place within a large--scale redshift survey of X-ray clusters of galaxies detected by the ROSAT All Sky Survey, a so-called ``ESO Key Programme'' led by astronomers from the Max-Planck-Institut fur Extraterrestrische Physik and the Osservatorio Astronomico di Brera. The main aim of this programme is to identify cluster X-ray sources, to determine the distance to the X-ray emitting clusters and to investigate their overall properties. These observations permitted to measure the redshift of the RXJ1347.5-1145 cluster as z = 0.45, i.e. it moves away from us with a velocity (about 106,000 km/sec) equal to about one-third of the velocity of light. This is an effect of the general expansion of the universe and it allows to determine the distance as about 5,000 million light-years (assuming a Hubble constant of 75 km/sec/Mpc). In other words, we see these

  2. ERIS: preliminary design phase overview

    Science.gov (United States)

    Kuntschner, Harald; Jochum, Lieselotte; Amico, Paola; Dekker, Johannes K.; Kerber, Florian; Marchetti, Enrico; Accardo, Matteo; Brast, Roland; Brinkmann, Martin; Conzelmann, Ralf D.; Delabre, Bernard A.; Duchateau, Michel; Fedrigo, Enrico; Finger, Gert; Frank, Christoph; Rodriguez, Fernando G.; Klein, Barbara; Knudstrup, Jens; Le Louarn, Miska; Lundin, Lars; Modigliani, Andrea; Müller, Michael; Neeser, Mark; Tordo, Sebastien; Valenti, Elena; Eisenhauer, Frank; Sturm, Eckhard; Feuchtgruber, Helmut; George, Elisabeth M.; Hartl, Michael; Hofmann, Reiner; Huber, Heinrich; Plattner, Markus P.; Schubert, Josef; Tarantik, Karl; Wiezorrek, Erich; Meyer, Michael R.; Quanz, Sascha P.; Glauser, Adrian M.; Weisz, Harald; Esposito, Simone; Xompero, Marco; Agapito, Guido; Antichi, Jacopo; Biliotti, Valdemaro; Bonaglia, Marco; Briguglio, Runa; Carbonaro, Luca; Cresci, Giovanni; Fini, Luca; Pinna, Enrico; Puglisi, Alfio T.; Quirós-Pacheco, Fernando; Riccardi, Armando; Di Rico, Gianluca; Arcidiacono, Carmelo; Dolci, Mauro

    2014-07-01

    The Enhanced Resolution Imager and Spectrograph (ERIS) is the next-generation adaptive optics near-IR imager and spectrograph for the Cassegrain focus of the Very Large Telescope (VLT) Unit Telescope 4, which will soon make full use of the Adaptive Optics Facility (AOF). It is a high-Strehl AO-assisted instrument that will use the Deformable Secondary Mirror (DSM) and the new Laser Guide Star Facility (4LGSF). The project has been approved for construction and has entered its preliminary design phase. ERIS will be constructed in a collaboration including the Max- Planck Institut für Extraterrestrische Physik, the Eidgenössische Technische Hochschule Zürich and the Osservatorio Astrofisico di Arcetri and will offer 1 - 5 μm imaging and 1 - 2.5 μm integral field spectroscopic capabilities with a high Strehl performance. Wavefront sensing can be carried out with an optical high-order NGS Pyramid wavefront sensor, or with a single laser in either an optical low-order NGS mode, or with a near-IR low-order mode sensor. Due to its highly sensitive visible wavefront sensor, and separate near-IR low-order mode, ERIS provides a large sky coverage with its 1' patrol field radius that can even include AO stars embedded in dust-enshrouded environments. As such it will replace, with a much improved single conjugated AO correction, the most scientifically important imaging modes offered by NACO (diffraction limited imaging in the J to M bands, Sparse Aperture Masking and Apodizing Phase Plate (APP) coronagraphy) and the integral field spectroscopy modes of SINFONI, whose instrumental module, SPIFFI, will be upgraded and re-used in ERIS. As part of the SPIFFI upgrade a new higher resolution grating and a science detector replacement are envisaged, as well as PLC driven motors. To accommodate ERIS at the Cassegrain focus, an extension of the telescope back focal length is required, with modifications of the guider arm assembly. In this paper we report on the status of the

  3. Satellite Observation of Atmospheric Nuclear Gamma Radiation

    Science.gov (United States)

    1987-08-31

    Institut fur Physik und Astrophysik Garching, Federal Republic of Germany Contract: #N00014-87-C-2251 Naval Research Laboratory 4555 Overlook Avenue, S.W...03824 E. Rieger Institut fur Extraterrestriche Physik Max Planck Institut fur Physik und Astrophysik , Garching, FRG Naa-RsachLbraoy Wahntn DC 07 ABSTRACT

  4. A Scientific Basis for an Alternate Cathode Architecture.

    Science.gov (United States)

    1988-02-01

    Phys. Z. 15, 872 (1914)-Z. Physik 14, 63 (1923). 11. "Encyclopaedic Dictionary of Physics", J. Thewlis editor; Oxford-London-New York-Paris...Dushman, Phys. Rev. 21, 623 (1923). 7. A. Sommerfeld, Z. Physik 47, 1 (1928). 8. L. Nordheim, Z Physik 30, 177 (1929). * 9. loc. cit. 10. W. Schottky

  5. Philosophy of quantum physics. Introduction and discussion of the central perceptions and problem, posings of quantum theory for physicsts and philosophers; Philosophie der Quantenphysik. Einfuehrung und Diskussion der zentralen Begriffe und Problemstellungen der Quatentheorie fuer Physiker und Philosophen

    Energy Technology Data Exchange (ETDEWEB)

    Friebe, Cord [Bonn Univ. (Germany). Inst. fuer Philosophie; Kuhlmann, Meinard [Bielefeld Univ. (Germany). Abteilung Philosophie; Lyre, Holger [Magdeburg Univ. (Germany). Inst. fuer Philosophie; Naeger, Paul [Muenster Univ. (Germany). Philosophisches Seminar; Passon, Oliver [Bergische Univ., Wuppertal (Germany). Fachbereich Physik; Stoeckler, Manfred [Bremen Univ. (Germany). Inst. fuer Philosophie

    2015-07-01

    The aim was to give advanced students of philosophy with interest for physics an actual and solid introduction to the quantum theory. Simultaneously the book confronts also physicists with the philosophical questions of their field. After clearance of the foundations the second chapters introduces to the minimal interpretation and the ''Copenhagen interpretation''. In the third chapter many-particle systems are introduced and their pecularities discussed. The fourth chapter deals with the theme-circle ''entangled states'' and ''nonlocality''. In the first parter of the fifth chapter the De-Broglie-Bohm theory and in the second part the many-world interpretation of the quantum theory are presented. In the sixth chapter the bow is spanned to (relativistic) quantum field theories. Finally the seventh chapter rounds the book off in the framework of a small chronology of important development steps in physical-mathematical as also interpretatorical view.

  6. Continuum of quanta in the final theory. Model of spiral fields. Basic ideas for a compatible physics and a consistent nature science. 4. rev. ed.; Quantenkontinuum in der Finaltheorie. Spiralfeldmodell. Grundgedanken fuer eine Kompatible Physik und eine Konsistente Naturwissenschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hartje, Udo Albert Juergen

    2009-07-01

    The internationally favored direction of the physics sciences looks for the solution of the basic problems in higher and higher energies at impressive research constructions - mockingly mentioned as 'cognition machines' - which surpass itself with its financial efforts each the other. If in this wise shall be found: 'The elementariest bit of all elements' and 'the unity of the whole physics as well as the whole nature sciences at all', then this is a thought aberration. The prognosticated HIGGS-particles may have an exceptional quality; however, they would be very complex objects which integrate an enormous number of effect-quanta h (Planck constants) in their structure: They are with safety not simplicity. They will also not bring a better understanding about the simplicity of the last elements for us. We know since Planck, Poincare, Einstein, Bohr, Heisenberg, Schroedinger, DeBrogue and other well-known physicists that the 'atomos' can have only a diminutiveness discrete not measurable energy. The search with gigantic machines is at all especially nonsensical than it pumps still energy into the processes. However, the elementary consists of fractions from that energy what have well-known smallest particles or weakest radiation in itself puts. The work in hand follows another approach. It grasps nature on a deductive way. I start out from a most general analysis and synthesis of scientific and everyday-language concepts; and I combine that with a principle of 'general physical field' which after Einstein must exist. The dynamic space-time processes of the fields are depicted by graphic means in mathematical spatial coordinate-systems. Through it arises a consistent view over all areas of the knowledge from the most simply over simple structures until to the most complicated phenomena and things: that one are the cognition remained secretive till now obstinately. In the foreground will be originate as important the solution of the puzzle around the 'Dualism of Waves and Particles'. Structures of matter do not consist of any a priori, i.e. out the beginning existing tiniest primordial particles that secondarily swings; but they generate themselves from radiation which does not interrupt their light-fast movement in the interior of particles; and therefore it remains radiation-like. The circulation in itself creates locality; without that the radiation lost their dynamics; and without that this radiation must itself change into electrons: with their secondary turn in the orbital path. The Classic Physics and the Quantum Physics amalgamate into the 'Spiral Field Model' (Model of Spiral Fields). Classic Physics and the Quantum Physics merge in a Model of Spiral Fields into a paramount thought building with a new imagination for radiation and particles. Molecules, atoms and seedless particles have to be analyzed on the new basis. The rich fundus of proven knowledge will help. Problems of the natural sciences which do not find any immediate explanation should be taken in relation to the new thoughts; therewith will the special aspects visible. A single human is not able to it in view of the gigantic range of the accumulated knowledge. (orig.)

  7. Conductors, semiconductors, superconductors. An introduction to solid-state physics. For physicists, engineers, and natural scientists; Leiter, Halbleiter, Supraleiter. Eine Einfuehrung in die Festkoerperphysik. Fuer Physiker, Ingenieure und Naturwissenschaftler

    Energy Technology Data Exchange (ETDEWEB)

    Huebener, Rudolf

    2013-11-01

    The present book gives an introduction to the foundations of solid-state physics, whereby also the contributing persons and their environment are illuminated. The main topic lies in the electrical and magnetical material properties.

  8. 5. German congress on radiation oncology, radiobiology and medical physics. Book of abstracts, DEGRO congress; 5. Deutscher Kongress fuer Radioonkologie, Strahlenbiologie und Medizinische Physik. Abstractband zum DEGRO-Kongress

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1999-11-01

    The special issue of the journal covers the scientific conference program, encompassing 32 symposia and the invited papers, as well as about 300 scientific papers and posters presented at the congress. Most of the papers of the symposium sessions take a cross-disciplinary approach in discussing the large tumor entities and recent advances on the technical and biological level. Subject clusters are medical and physical quality assurance and radiobiology, CNS, ENT, brachytherapy, and benign tumors. One symposium gathered specialists discussing economic and legal aspects. Further topical fields are foreeseable trends and innovative developments for the treatment of cancer of the prostate, breast, and bronchial tract, or enhanced application of radiochemotherapy, the knowledge and contributions from the field of molecular biology, and new technology, including the new media. (orig./CB) [German] Das wissenschaftliche Programm setzt sich zusammen aus 32 Symposien und jeweils ca. 300 freien Vortraegen und Posterpraestentationen. In den Symposien werden mehrheitlich interdisziplinaer sowohl die grossen Tumorentitaeten als auch technische und biologische Neuerungen vorgestellt. Thematische Schwerpunkte sind die medizinische und physikalische Qualitaetssicherung sowie die Strahlenbiologie, gefolgt von den Themenbereichen ZNS, HNO, Brachytherapie und gutartigen Erkrankungen. Ein Symposium widmet sich Wirtschaftlichkeits- und Rechtsfragen. Weitere zukunftsweisende Themenschwerpunkte sind Innovationen beim Prostata-, Mamma- und Bronchialkarzinom sowie der zunehmende Einsatz der Radiochemotherapie, die Nutzung der Kenntnisse aus der Molekularbiologie und technische Neuerungen inklusive der neuen Medien. (orig.)

  9. DEGRO 2013. 19. annual congress of the German Radiation Oncology Society. Radiation oncology - medical physics - radiation biology. Abstracts; DEGRO 2013. 19. Jahreskongress der Deutschen Gesellschaft fuer Radioonkologie. Radioonkologie - Medizinische Physik - Strahlenbiologie. Abstractband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-05-15

    The volume includes abstracts from the DEGRO 2013, 19. annual congress of the German Radiation Oncology Society concerning the lectures: protons and heavy ions; radiobiology; combined radio-chemotherapy; high precision radiotherapy; malign brain tumors; gynecological and urogenital carcinoma; head and neck carcinoma, toxicity and supportive therapy. The poster abstracts cover the following issues: High precision radiotherapy IMRT, IGRT, stereotaxis, brachytherapy and tomotherapy; protons and heavy ions; combined radio-chemotherapy - simultaneous or sequential? Supportive measures and side effect management in radio-oncology, symptom-oriented radiotherapy - interdisciplinary integration of radio-oncology; radio-oncology as cooperation partner in organ centers, oncological centers and comprehensive cancer centers, reliability, network security; paperless radio-oncology; mamma carcinoma, urogenital carcinoma, lung tumor, gastrointestinal tumors, head and neck carcinoma, brain tumors, seldom tumors, radiobiology, radiation physics.

  10. Physics, radiology, and chemistry. An introduction to natural science. Textbook for the medical professions and nursing training centres. 7. rev. ed. Physik, Strahlenkunde und Chemie. Eine Einfuehrung in diese Naturwissenschaften. Studienbuch fuer Angehoerige der Heilberufe und Krankenpflegeschulen

    Energy Technology Data Exchange (ETDEWEB)

    Linde, O.K.; Knigge, H.J.

    1986-01-01

    This book is an introduction to physics and chemistry especially for medical personnel. After a general introduction, measurement methods, mechanics including mechanics of solid bodies, fluids and gases, heat, optics, acoustics, electricity, radiations including their biological effects, general chemistry, inorganic and organic chemistry are treated. Every chapter contains exercises mostly in connection with medical and biological effects. Furthermore, connections with biology and medicine are considered. The chapters on physiological chemistry, computer and information theory, chemistry and ecology, and metabolism have been rewritten. (HP).

  11. Physics, radiology, and chemistry. An introduction to natural science. Textbook for the medical professions and nursing training centres. 8. rev. ed. Physik, Strahlenkunde und Chemie. Eine Einfuehrung in diese Naturwissenschaften. Studienbuch fuer Angehoerige der Heilberufe und Krankenpflegeschulen

    Energy Technology Data Exchange (ETDEWEB)

    Linde, O.K.; Knigge, H.J.

    1991-01-01

    This book is an introduction to physics and chemistry especially for medical personnel. After a general introduction, measurement methods, mechanics including mechanics of solid bodies, fluids and gases, heat, optics, acoustics, electricity, radiations including their biological effects, general chemistry, inorganic and organic chemistry are treated. Every chapter contains exercises mostly in connection with medical and biological effects. Furthermore connections with biology and medicine are considered. (orig./HP) With 104 figs., 51 tabs.

  12. Fascinating physics. An illustrated expedition from the universe until the world of the elementary particles. 2. ed.; Faszinierende Physik. Ein bebilderter Streifzug vom Universum bis in die Welt der Elementarteilchen

    Energy Technology Data Exchange (ETDEWEB)

    Bahr, Benjamin [Albert-Einstein-Institut (Max-Planck Institut fuer Gravitationsphysik), Golm (Germany); Riebe, Kristin [Potsdam Univ. (Germany). Leibniz-Institut fuer Astrophysik; Resag, Joerg

    2015-07-01

    The present book is an expedition across modern physics and simultaneously an illustrated voyage through the solved and unsolved enigmas of our universe. The twentieth century brought a manifold of physical discoveries. The atomic structure of matter was experimentally proved, and stepwise the structure of the atoms was decoded. Alber Einstein revolutionized with his special and general relativity theory our understanding of spca and time and unified so mechanic with electrodynamics and gravitation. Probably the most momentous upheaval learned our worldview by quantum mechanics. In the second half of the twentieth century by ever larger particle accelerators it was increasingly faced deeper penetrated into the structure of matter. Around the year 1967 it succeeded to answer the hereby occurring questions in the framework of the so-called Standard Model. Beside these fields also further partial fields of physics exist,which are not so closely connected with the inquiry of natural laws. We have four of these fields token in our book: Solid-state physics, geophysics, astronomy with astrophysics, as well as cosmology.

  13. Youngest Brown Dwarf Yet in a Multiple Stellar System

    Science.gov (United States)

    2000-07-01

    that direct detection and subsequent, effective spectroscopic verification of extra-solar planets is now quite feasible with a ground-based facility like the VLT. It is thus not a very daring prediction that the ongoing searches may soon lead to the first direct images of an extra-solar planet. These are indeed exciting times! More information The work described in this Press Release is discussed by the team in a research article that has been accepted for publication in the European journal Astronomy & Astrophysics. Another paper ( "Direct imaging search for planetary companions next to young nearby stars" ) is also available with more details about the current searches, including the spectrum of the background star at TWA-7. The Principal Investigator for this project may be contacted at: Ralph Neuhaeuser Max-Planck-Institut für Extraterrestrische Physik D-85748 Garching Germany Phone +49-89-32993398 email: rne@mpe.mpg.de Notes [1]: The team consists of Ralph Neuhaeuser (Principal Investigator) and Nuria Huelamo (both Max-Planck-Institut für Extraterrestrische Physik, Garching, Germany), Eike Guenther (Landessternwarte Tautenburg, Germany), Monika Petr (Max-Planck-Institut für Radioastronomie, Bonn, Germany), Wolfgang Brandner (Institute for Astronomy, Honolulu, Hawaii, USA) and João Alves (ESO, Garching, Germany). [2]: The hitherto sharpest image (0.25 arcsec) was obtained in March 1999, cf. ESO PR 06/99. It was obtained during a period of exceptionally good "seeing" (low level of atmospheric turbulence). The installation of adaptive optics at the VLT, foreseen in 2001, will provide a means to overcome the image smearing effect of air turbulence and hence, consistently obtain stellar images of a few hundredths of an arcsecond diameter, near the theoretical limit for an 8.2-m telescope (the telescope diffraction limit ). [3]: 1 solar mass = 2 x 10 30 kg. 1 Jupiter mass = 2 x 10 27 kg ~ 0.001 solar mass. Thus, the "BD-limit" of 0.08 solar masses corresponds to

  14. New Insight into the Cosmic Renaissance Epoch

    Science.gov (United States)

    2003-08-01

    at even higher redshifts" , adds Matthew Lehnert. "With a larger sample of such distant objects, we can then obtain insight into their nature and the variation of their density in the sky." A British Premiere The observations presented here are among the first major discoveries by British scientists since the UK became a member of ESO in July 2002. Richard Wade from the Particle Physics and Astronomy Research Council ( PPARC), which funds the UK subscription to ESO, is very pleased: " In joining the European Southern Observatory, UK astronomers have been granted access to world-leading facilities, such as the VLT. These exciting new results, of which I am sure there will be many more to come, illustrate how UK astronomers are contributing with cutting-edge discoveries. " More information The results described in this Press Release are about to appear in the research journal Astrophysical Journal (" Luminous Lyman Break Galaxies at z>5 and the Source of Reionization" by M. D. Lehnert and M. Bremer). It is available electronically as astro-ph/0212431 . Notes [1]: This is a coordinated ESO/PPARC Press Release. The PPARC version of the release can be found here. [2]: This work was carried out by Malcolm Bremer (University of Bristol, The United Kingdom) and Matthew Lehnert (Max-Planck-Institut für Extraterrestrische Physik, Garching, Germany). [3]: The measured redshifts of the galaxies in the Bremer Deep Field are z = 4.8-5.8, with one unexpected (and surprising) redshift of 6.6. In astronomy, the redshift denotes the fraction by which the lines in the spectrum of an object are shifted towards longer wavelengths. The observed redshift of a remote galaxy provides an estimate of its distance. The distances indicated in the present text are based on an age of the Universe of 13.7 billion years. At the indicated redshift, the Lyman-alpha line of atomic hydrogen (rest wavelength 121.6 nm) is observed at 680 to 920 nm, i.e. in the red spectral region.

  15. CD163+ tumor-associated macrophage is a prognostic biomarker and is associated with therapeutic effect on malignant pleural effusion of lung cancer patients.

    Science.gov (United States)

    Yang, Li; Wang, Fei; Wang, Liping; Huang, Lan; Wang, Jing; Zhang, Bin; Zhang, Yi

    2015-04-30

    CD163+ tumor-associated macrophages (TAMs) play an important role in the progression of cancer. However, the significance of CD163+ TAMs in malignant pleural effusion (MPE) is still unclear. The aim of this study is to evaluate the prognostic value of CD163+ TAMs in MPE, and the regulatory effect of an immune adjuvant (pseudomonas aeruginosa - mannose-sensitive hemagglutinin, PA-MSHA, which is used for MPE treatment in clinic) on CD163+ TAMs in MPE. Here, we found that the percentage of CD163+ TAMs in MPE was significantly higher than that in non-malignant pleural effusion (PCD163+ TAMs in MPE patients were an independent prognostic factor for progression-free survival. M2-related cytokines were highly expressed in MPE-derived CD163+ TAMs than in MPE-derived CD163- macrophages (PCD163+ TAMs frequency in MPE patients was obviously reduced after PA-MSHA treatment in clinic (PCD163+ TAMs in MPE caused by lung cancer is closely correlated with poor prognosis. CD163+ TAMs are associated with therapeutic effect in MPE. PA-MSHA re-educates CD163+ TAMs to M1 macrophages through TLR4-mediated pathway in MPE.

  16. International Conference on the Physics of Electronic and Atomic Collisions (14th) Held in Palo Alto, California on 24-30 July 1985 (Electronic and Atomic Collisions. Invited Papers)

    Science.gov (United States)

    1985-07-30

    Report ORNL/TM-9436 (March 1985). 214 D C Gregory 12) Wolfgang Lo.tz, Z. Physik 206 (1967) 205; Z. Physik 216 (1968) 241; Z. Physik 220 (1969) 466...and Ni foils placed in front of the Si(Li) 54___F. Torge FIGURE 3 382 J. E Ch emin (I al. detector. We kept the counting rate in the x-ray detector...MULLER 2 , A. SCHAFER’, P. SCHLUTER 2 , S. SCHRAMM’, and G. SOFF2 ’Institut fUr Theoretische Physik der Johann Wolfgang Goethe-Universit~t Robert-Mayer

  17. Spectral-Product Methods for Electronic Structure Calculations (Postprint)

    Science.gov (United States)

    2007-06-12

    and electronically excited potential energy surfaces in Monte Carlo and molecular dynamics simula- tions of singly doped inert-gas clusters [27], the...Matsunaga N, Nguyen KA, Su SJ, Windus TL, Dupuis M, Montgomery JA (1993) J Comput Chem 14:1347 3. Pauli W (1925) Z Physik 31:765 4. Heisenberg W (1926) Z...Physik 38:411 5. Heisenberg W (1926) Z Physik 39:499 6. Heisenberg W (1926) Z Physik 40:501 7. Dirac PAM (1926) Proc R Soc (London) A 112:661 8

  18. EDITORIAL: Invited review and topical lectures from the 13th International Congress on Plasma Physics

    Science.gov (United States)

    Zagorodny, A.; Kocherga, O.

    2007-05-01

    The 13th International Congress on Plasma Physics (ICPP 2006) was organized, on behalf of the International Advisory Committee of the ICPP series, by the National Academy of Sciences of Ukraine and the Bogolyubov Institute for Theoretical Physics (BITP) and held in Kiev, Ukraine, 22 26 May 2006. The Congress Program included the topics: fundamental problems of plasma physics; fusion plasmas; plasmas in astrophysics and space physics; plasmas in applications and technologies; complex plasmas. A total of 305 delegates from 30 countries took part in the Congress. The program included 9 invited review lectures, 32 invited topical and 313 contributed papers (60 of which were selected for oral presentation). The Congress Program was the responsibility of the International Program Committee: Anatoly Zagorodny (Chairman) Bogolyubov Institute for Theoretical Physics, Ukraine Olha Kocherga (Scientific Secretary) Bogolyubov Institute for Theoretical Physics, Ukraine Boris Breizman The University of Texas at Austin, USA Iver Cairns School of Physics, University of Sydney, Australia Tatiana Davydova Institute for Nuclear Research, Ukraine Tony Donne FOM-Institute for Plasma Physics, Rijnhuizen, The Netherlands Nikolai S Erokhin Space Research Institute of RAS, Russia Xavier Garbet CEA, France Valery Godyak OSRAM SYLVANIA, USA Katsumi Ida National Institute for Fusion Science, Japan Alexander Kingsep Russian Research Centre `Kurchatov Institute', Russia E P Kruglyakov Budker Institute of Nuclear Physics, Russia Gregor Morfill Max-Planck-Institut für extraterrestrische Physik, Germany Osamu Motojima National Institute for Fusion Science, Japan Jef Ongena ERM-KMS, Brussels and EFDA-JET, UK Konstantyn Shamrai Institute for Nuclear Research, Ukraine Raghvendra Singh Institute for Plasma Research, India Konstantyn Stepanov Kharkiv Institute of Physics and Technology, Ukraine Masayoshi Tanaka National Institute for Fusion Science, Japan Nodar Tsintsadze Physics Institute, Georgia The

  19. PREFACE: The Universe under the Microscope: Astrophysics at High Angular Resolution

    Science.gov (United States)

    Schödel, Rainer

    2009-01-01

    Köln, Köln, Germany Eduardo Ros Max-Planck-Institut für extraterrestrische Physik, Bonn, Germany Scientific organizing committee Dennis Downes Institut de Radio Astronomie Millimétrique, France Wolfgang Duschl University of Kiel, Germany Andrea Ghez University of California, Los Angeles, USA Vladimir Karas Academy of Sciences, Czech Republic Andreas Eckart University of Cologne, Germany Sera Marko University of Amsterdam, The Netherlands Susanne Pfalzner University of Cologne, Germany Sebastian Rabien Max-Planck-Institute for Extraterrestrial Physics, Germany Daniel Rouan Observatoire de Paris-Meudon, France Eduardo Ros Max-Planck-Institute for Radio Astronomy, Germany Rainer Schödel Instituto de Astrofísica de Andalucía -CSIC, Spain Zhiqiang Shen Shanghai Astronomical Observatory, China Anton Zensus Max-Planck-Institute for Radio Astronomy, Germany Local organizing committee Sebastian Fischer University of Cologne, Germany Devaky Kunneriath University of Cologne, Germany Leo Meyer University of Cologne, Germany Koraljka Muzic University of Cologne, Germany Rainer Schödel University of Cologne, Germany/IAA -CSIC, Spain Christian Straubmeier University of Cologne, Germany Mohammad Zamaninasab University of Cologne, Germany

  20. OECD Global Science Forum's Astronomy Workshop to take place in Munich

    Science.gov (United States)

    2003-11-01

    members of the national astronomical community. The International Astronomical Union (IAU) and the European Southern Observatory (ESO) are explicitly represented. Experts from the world-wide astronomy community have been invited to set the stage and provide input for the discussions. The choice by Germany and the OECD to make Munich the venue of this Global Science Forum Workshop is no coincidence. It is a recognition of the important role played by many institutions in the Munich region in the field of Astronomy and Astrophysics. They include the Ludwig-Maximilians-Universität where the Workshop will take place, the Max-Planck-Institut für Astrophysik, the Max-Planck Institut für Extraterrestrische Physik and the European Southern Observatory. These institutions are all participating in large programmes and projects in astronomy. ESO, for its part, is at the leading edge of world astronomy with its flagship facility, the Very Large Telescope in Paranal (Chile) and the newly started ALMA project at Chajnantor (Chile), being carried out in partnership between Europe and North America. Public Talks (Munich) on December 1, 2003 As a prelude to the Workshop, two public keynote presentations will take place on December 1 at the Deutsches Museum in Munich at 18:00 CET. The speakers are Malcolm Longair, Jacksonian Professor of Natural Philosophy and Head of Laboratory, Cavendish Laboratory, Cambridge (UK) and Martin Harwit, Professor Emeritus of Astronomy, Cornell University, and former Director of the National Air and Space Museum, Washington, DC (USA). The talks will be given in English and the entry to this public event is free. Professor Longair will speak on "Astrophysics and Cosmology in the Twenty-First Century" and Professor Harwit will speak on "The Growth of Understanding of our Universe". You can find more informaton on the Public Talks web page.

  1. 逐饮Ⅰ号对恶性胸水大鼠模型血清TUM2-PK含量和胸膜组织bFGF表达的影响%Effect on TUM2 - PK in Serum of MPE Rat Model and bFGF in Its Membrana Pleuralis Treated by Zhu Yin Ⅰ

    Institute of Scientific and Technical Information of China (English)

    刘建秋; 李竹英; 蒋鹏娜

    2009-01-01

    目的:观察逐饮Ⅰ号对恶性胸水大鼠模型血清中肿瘤M2型丙酮酸激酶(TUM2-PK)和胸膜组织中碱性成纤维细胞因子(bFGF)的影响.方法:建立艾氏腹水瘤细胞株(EAC)恶性胸水大鼠模型,用ELISA法检测恶性胸水大鼠血清中TUM2-PK的含量,免疫组化法测定胸膜组织中bFGF的表达.结果:①恶性胸水大鼠模型组的血清TUM2-PK含量明显高于正常空白组,中药组、顺铂组、中药+顺铂组血清TUM2-PK含量明显低于模型组,中药+顺铂组的血清TUM2-PK含量明显低于顺铂组和中药组,中药组与顺铂组含量相近.②恶性胸水大鼠模型组的胸膜组织bFGF表达,明显高于空白组,中药组、顺铂组、中药加顺铂组的bFGF表达低于模型组,中药+顺铂组的bFGF表达,明显低于顺铂组和中药组,中药组与顺铂组相近.结论:①逐饮Ⅰ号可明显降低恶性胸水大鼠模型血清TUM2-PK含量.②逐饮Ⅰ号可明显降低恶性胸水大鼠模型胸膜组织bFGF表达.③逐饮Ⅰ号可能通过降低恶性胸水大鼠模型血清TUM2-PK含量及胸膜组织bFGF表达,达到抑制恶性胸水的目的.

  2. Boltzmann und das Ende des mechanistischen Weltbildes

    CERN Document Server

    Renn, Jürgen

    2007-01-01

    Der Wissenschaftshistoriker und Physiker Jürgen Renn untersucht die Rolle des österreichischen Physikers und Philosophen Ludwig Boltzmann (18441906) bei der Entwicklung der modernen Physik. Boltzmann war einer der letzen Vertreter des mechanistischen Weltbildes und stand somit am Ende eines Zeitalters. Renn porträtiert den Wissenschaftler aber als einen Pionier der modernen Physik, dessen Beschäftigung mit den inneren Spannungen der klassischen Physik ihn visionär zukünftige Fragestellungen aufgreifen ließ. So befasste sich Boltzmann etwa mit den Grenzproblemen zwischen Mechanik und Thermodynamik, die ihn zur Entwicklung immer raffinierterer Instrumente der statistischen Physik antrieb, die schließlich zu Schlüsselinstrumenten der modernen Physik wurden. Boltzmanns Werk steht somit am Übergang vom mechanistischen Weltbild zur Relativitäts- und Quantentheorie. Der Aussage des viel bekannteren Physikers Albert Einstein, dass Fantasie wichtiger sei als Wissen, hält Jürgen Renn im Hinblick auf Leben ...

  3. Unravelling the potential of nitric acid as a surface modifier for improving the hemocompatibility of metallocene polyethylene for blood contacting devices

    Science.gov (United States)

    Vellayappan, Muthu Vignesh; Muhamad, Ida Idayu

    2016-01-01

    Design of blood compatible surfaces is obligatory to minimize platelet surface interactions and improve the thromboresistance of foreign surfaces when they are utilized as biomaterials particularly for blood contacting devices. Pure metallocene polyethylene (mPE) and nitric acid (HNO3) treated mPE antithrombogenicity and hydrophilicity were investigated. The contact angle of the mPE treated with HNO3 decreased. Surface of mPE and HNO3 treated mPE investigated with FTIR revealed no major changes in its functional groups. 3D Hirox digital microscopy, SEM and AFM images show increased porosity and surface roughness. Blood coagulation assays prothrombin time (PT) and activated partial thromboplastin time (APTT) were delayed significantly (P hemocompatibility of HNO3 treated mPE. To determine that HNO3 does not deteriorate elastic modulus of mPE, the elastic modulus of mPE and HNO3 treated mPE was compared and the result shows no significant difference. Hence, the overall observation suggests that the novel HNO3 treated mPE may hold great promises to be exploited for blood contacting devices like grafts, catheters, and etc. PMID:26819837

  4. CD163+CD14+ macrophages, a potential immune biomarker for malignant pleural effusion.

    Science.gov (United States)

    Wang, Fei; Yang, Li; Gao, Qun; Huang, Lan; Wang, Liping; Wang, Jing; Wang, Shengdian; Zhang, Bin; Zhang, Yi

    2015-08-01

    Malignant pleural effusion (MPE) is a common complication caused by malignant diseases. However, subjectivity, poor sensitivity, and substantial false-negative rates of cytology assay hamper accurate MPE diagnosis. The aim of this study was to assess whether CD163+CD14+ tumor-associated macrophages (TAMs) could be used as a biomarker for enabling sensitive and specific MPE diagnosis. Pleural effusion samples and peripheral blood samples were collected from 50 MPE patients and 50 non-malignant pleural effusion (NMPE) patients, respectively. Flow cytometry was performed to analyze cell phenotypes, and RT-qPCR was used to detect cytokine expression in these monocytes and macrophages. A blinded validation study (n = 40) was subsequently performed to confirm the significance of CD163+CD14+ TAMs in MPE diagnosis. Student's t test, rank sum test, and receiver operating characteristic curve analysis were used for statistical analysis. Notably, CD163+CD14+ cell frequency in MPE was remarkably higher than that in NMPE (P CD163+CD14+ TAMs as a MPE biomarker. In total (n = 140), by using a cutoff level of 3.65 %, CD163+CD14+ cells had a sensitivity of 81.2 % and a specificity of 100 % for MPE diagnosis. Notably, MPE diagnosis by estimating CD163+CD14+ cells in pleural effusion could be obtained one week earlier than that obtained by cytological examination. CD163+CD14+ macrophages could be potentially used as an immune diagnostic marker for MPE and has better assay sensitivity than that of cytological analysis.

  5. Universe of quantum whirls in the final theory spiral field model. Basic ideas for a compatible physics and a consistent nature science. 2. rev. ed.; Universum der Quantenwirbel in der Finaltheorie Spiralfeldmodell. Grundgedanken fuer eine kompatible Physik und eine konsistente Naturwissenschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hartje, Udo A.J.

    2007-07-01

    Internationally stressed physics is looking for the solution of the basic problems of physics at higher and higher energies in impressive plants which outbid themselves in their expenditure for technology reciprocally. If with this manner shall be to seek the ''atomos'' and the ''unit of the physics'' then this is an error way. Sought-after Higgs particles are certainly not a simply thing; but a most complex object which would contain an enormous number of effect quanta in its structure. Since Planck, Poincare, Einstein, Bohr, Heisenberg, Schroedinger, De Broglie and others well-known physicists we know that this ''atomos'' have only a tiny energy quantity which single is not measurable. The search with gigantic machines is at all besides more nonsensical than such processes there will pump even energy into it. The elementary contains only fractions from the energy what is in known smallest particles or weakest beams too. This work follows another approach to grasp the nature in a Final Theory (Grand Unification) on a deductive way. It starts from a most general analysis and synthesis of scientific and everyday-language concepts. This shored up it on the principle of general physical field. The dynamic processes of the field are vivid illustrated by graphic means in systems of coordinates with space-time. Through it arises a everywhere consistent view for most simple existences and simple structures up to most complicate existences for all fields of physics and philosophy. That remained shut off till now obstinately for the cognition. A important result is the solution of the puzzle of ''Dualism of Wave and Particle''. Matter-structures consist not from 'a priori' existing 'little verdicts' which secondary swing. But they consist from beams; which remain in the inside of the particles radiation-like: and they rotate there in themselves. This creates locality without changing the radiation itself into 'electrons' which rotate on paths. The Classical Physics and the Quantum Physics merge with a new radiation and particle model in the ''Spiral Field Model'' to an united primary edifice of ideas. Atoms and other particles must be analyzed on a new basis in which the rich fund of recognized knowledge will help. Some puzzles come to solution alone by the new position. Other unsolved problems of the nature science must be brought in connection with the strange thoughts; that the individual aspects will visibly. A single person is not able to it in the face of the gigantic mountain at accumulated knowledge. (orig.)

  6. Universe of quantum whirls in the final theory spiral field model. Basic ideas for a compatible physics and a consistent nature science. 3. rev. ed.; Universum der Quantenwirbel in der Finaltheorie Spiralfeldmodell. Grundgedanken fuer eine kompatible Physik und eine konsistente Naturwissenschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hartje, Udo A.J.

    2008-07-01

    Internationally stressed physics is looking for the solution of the basic problems of physics at higher and higher energies in impressive plants which outbid themselves in their expenditure for technology reciprocally. If with this manner shall be to seek the ''atomos'' and the ''unit of the physics'' then this is an error way. Sought-after Higgs particles are certainly not a simply thing; but a most complex object which would contain an enormous number of effect quanta in its structure. Since Planck, Poincare, Einstein, Bohr, Heisenberg, Schroedinger, De Broglie and others well-known physicists we know that this ''atomos'' have only a tiny energy quantity which single is not measurable. The search with gigantic machines is at all besides more nonsensical than such processes there will pump even energy into it. The elementary contains only fractions from the energy what is in known smallest particles or weakest beams too. This work follows another approach to grasp the nature in a Final Theory (Grand Unification) on a deductive way. It starts from a most general analysis and synthesis of scientific and everyday-language concepts. This shored up it on the principle of general physical field. The dynamic processes of the field are vivid illustrated by graphic means in systems of coordinates with space-time. Through it arises a everywhere consistent view for most simple existences and simple structures up to most complicate existences for all fields of physics and philosophy. That remained shut off till now obstinately for the cognition. A important result is the solution of the puzzle of ''Dualism of Wave and Particle''. Matter-structures consist not from 'a priori' existing 'little verdicts' which secondary swing. But they consist from beams; which remain in the inside of the particles radiation-like: and they rotate there in themselves. This creates locality without changing the radiation itself into 'electrons' which rotate on paths. The Classical Physics and the Quantum Physics merge with a new radiation and particle model in the ''Spiral Field Model'' to an united primary edifice of ideas. Atoms and other particles must be analyzed on a new basis in which the rich fund of recognized knowledge will help. Some puzzles come to solution alone by the new position. Other unsolved problems of the nature science must be brought in connection with the strange thoughts; that the individual aspects will visibly. A single person is not able to it in the face of the gigantic mountain at accumulated knowledge. (orig.)

  7. X-rays, radiometers and skin unit dose. The development of measuring methods and measuring units for X radiation in medical physics from the beginning until the international standardization; X-Strahlen, Radiometer und Hauteinheitsdosis. Die Entwicklung der Messverfahren und Masseinheiten fuer Roentgenstrahlung in der medizinischen Physik von den Anfaengen bis zur internationalen Standardisierung

    Energy Technology Data Exchange (ETDEWEB)

    Glessmer-Junike, Simone

    2015-01-22

    X-rays, a special form of ionizing radiation, have been utilized in medicine and technology ever since their discovery at the end of 1895. However, the usage of X-rays made the development of measuring techniques necessary. Newly-developed measuring devices were at first called radiometers', but later the term dosimeter' has gained universal acceptance. The development of numerous dosimeters used in radiotherapy was accompanied by new units of measurement, each corresponding to its individual newly constructed dosimeter or method of measurement. While at first conversions between old and new units were performed, it later became clear that both within Germany and Europe units with similar names were used with different meanings, which was both incompatible and confusing. The first serious attempts of a standardization of units in Germany were made after the First World War, when the when the ionizing properties of X-rays was focused on for both measurements and unit definitions. Efforts towards an international standardization of units became successful in the mid-1920s when the Roentgen was defined as the universal unit. From the development described above, four stages of the evolution of radiation measurement and units in radiotherapy could be identified by means of comprehensive systematic research in printed publications. The first stage was the period of diagnostic application of X-rays, when tools for the determination of X-ray quality were designed. This stage progressed into that of therapeutic administration of X-rays shortly after, when instruments and units for the measurement of X-ray quantities (dose') were implemented. Due to the variety and diversity of measurement apparatus and units a third stage emerged, closely interconnected with the second. During the third stage, a nation-wide standardization was attempted in Germany. With the conclusion of this stage - the resolution of a unit for dose measurement in Germany - the stage of international standardization began. This fourth stage continues arguably to the present day, since by now not only units, but also standards for both measurement of these units and quality assurance, are developed in international cooperation. This study presents how present-day knowledge of fundamental physical laws, of potential measurement errors and of shortcomings of methods contribute to a better understanding of the historical process of the development portrayed here. When applying scientific discoveries to medicine and technology, this historical knowledge is an essential prerequisite for successful communication in a globalized world, which depends on international standards for manufacturing and application of measurement devices.

  8. Mentha pulegium extract as a natural product for the inhibition of corrosion. Part I: electrochemical studies.

    Science.gov (United States)

    Khadraoui, Abdelkader; Khelifa, Abdellah; Boutoumi, Hocine; Hammouti, Belkheir

    2014-01-01

    The inhibitory effect of Mentha pulegium extract (MPE) on steel corrosion in 1 M HCl solution was investigated using potentiodynamic polarisation and electrochemical impedance spectroscopy. The inhibition efficiency of MPE was found to increase with the concentration and reached 88% at 33% (v/v). Polarisation measurements show that the natural extract acted as a mixed inhibitor. The remarkable inhibition efficiency of MPE was discussed in terms of blocking of electrode surface by adsorption of inhibitor molecules through active centres. The adsorption of MPE was found to accord with the Temkin isotherm.

  9. 马来酸酐及其酯接枝mPE增容PA 6/mPE共混物的制备%Properties of PA 6/metallocene PE blends compatibilized by maleic anhydride and dibutyl maleate grafted metallocene PE

    Institute of Scientific and Technical Information of China (English)

    赵连国; 张良均

    2012-01-01

    The author prepared maleic anhydride grafted metallocene polyethylene (Mpe) (Mpe-g-MAH) and dibutyl maleate grafted Mpe (Mpe-g-DBM) via aqueous suspension grafting. The grafted products were taken as compatibilizers of polyamide (PA) 6/Mpe and were applied to the preparation of ternary blends, such as polyamide(PA) 6/Mpe/Mpe-g-M A H or PA 6/Mpe/Mpe-g-DBM. The compatibility between PA 6 and Mpe in the ternary blends was greatly strengthened with increasing the amount of Mpe-g-MAH or Mpe-g-DBM, which led to a rise in y crystal and a reduction in a crystal of PA 6 in the blends. As a result, the toughness, especially the low temperature toughness of the ternary blends was improved. The compatibilizing and toughening efficiency of Mpe-g-DBM were inferior to those of Mpe-g-MAH in the ternary blends for the reason that the anhydride groups of the latter were easier to react with the amino or imino groups of PA 6 in comparison with the ester groups of the former, although Mpe-g-DBM had higher grafting ratio than Mpe-g-MAH did.%采用水相悬浮法制备了马来酸酐接枝茂金属聚乙烯(mPE-g-MAH)、马来酸二丁酯接枝茂金属聚乙烯(mPE-g-DBM),并以其为聚酰胺(PA)6/茂金属聚乙烯(mPE)共混物的增容剂,分别制备了PA 6/mPE/mPE-g-MAH,PA 6/mPE/mPE-g-DBM 三元共混物.随着mPE-g-MAH,mPE-g-DBM用量的增加,三元共混物中PA 6的γ晶型增多,α晶型减少,PA 6与rmPE的相容性加强,使三元共混物的韧性,特别是低温韧性提高.尽管mPE-g-DBM的接枝率比mPE-g-MAH高,但由于后者中的酸酐基团比前者的酯基更易与PA 6中的氨基、亚氨基反应,因此,mPE-g-DBM的增容、增韧效果不如mPE-g-MAH.

  10. Recursive Lexicographical Search

    DEFF Research Database (Denmark)

    Iskhakov, Fedor; Rust, John; Schjerning, Bertel

    2016-01-01

    (MPE) of these games, much less all of them. We propose a fast and robust generalization of backward induction we call state recursion that operates on a decomposition of the overall DDG into a finite number of more tractable stage games, which can be solved recursively. We provide conditions under...... which state recursion finds at least one MPE of the overall DDG and introduce a recursive lexicographic search (RLS) algorithm that systematically and efficiently uses state recursion to find all MPE of the overall game in a finite number of steps. We apply RLS to find all MPE of a dynamic model...

  11. NCBI nr-aa BLAST: CBRC-DNOV-01-1661 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1661 ref|YP_001023443.1| hypothetical protein Mpe_B0433 [Methylibium petrol...eiphilum PM1] ref|YP_001023477.1| hypothetical protein Mpe_B0468 [Methylibium petroleiphilum PM1] gb|AB...M97208.1| hypothetical protein Mpe_B0433 [Methylibium petroleiphilum PM1] gb|ABM97242.1| hypothetical protein Mpe_B0468 [Methylibium petroleiphilum PM1] YP_001023443.1 2.4 23% ...

  12. Impaired T cell function in malignant pleural effusion is caused by TGF-β derived predominantly from macrophages.

    Science.gov (United States)

    Li, Lifeng; Yang, Li; Wang, Liping; Wang, Fei; Zhang, Zhen; Li, Jieyao; Yue, Dongli; Chen, Xinfeng; Ping, Yu; Huang, Lan; Zhang, Bin; Zhang, Yi

    2016-11-15

    Malignant pleural effusion (MPE) is an indication of advanced cancer. Immune dysfunction often occurs in MPE. We aimed to identify the reason for impaired T cell activity in MPE from lung cancer patients and to provide clues toward potential immune therapies for MPE. The surface inhibitory molecules and cytotoxic activity of T cells in MPE and peripheral blood (PB) were analyzed using flow cytometry. Levels of inflammatory cytokines in MPE and PB were tested using ELISA. TGF-β expression in tumor-associated macrophages (TAMs) was also analyzed. The effect of TAMs on T cells was verified in vitro. Lastly, changes in T cells were evaluated following treatment with anti-TGF-β antibody. We found that expression levels of Tim-3, PD-1 and CTLA-4 in T cells from MPE were upregulated compared with those from PB, but levels of IFN-γ and Granzyme B were downregulated (p TGF-β was significantly higher in MPE than in PB (p TGF-β was mainly produced by TAMs in MPE. When T cells were co-cultured with TAMs, expression levels of Tim-3, PD-1 and CTLA-4 were significantly higher than controls, whereas levels of IFN-γ and Granzyme B were significantly decreased, in a dose-dependent manner (p TGF-β antibody restored the impaired T cell cytotoxic activity in MPE. Our results indicate that macrophage-derived TGF-β plays an important role in impaired T cell cytotoxicity. It will therefore be valuable to develop therapeutic strategies against TGF-β pathway for MPE therapy of lung cancer.

  13. Observing a Burst with Sunglasses

    Science.gov (United States)

    2003-11-01

    Unique Five-Week VLT Study of the Polarisation of a Gamma-Ray Burst Afterglow "Gamma-ray bursts (GRBs)" are certainly amongst the most dramatic events known in astrophysics. These short flashes of energetic gamma-rays, first detected in the late 1960's by military satellites, last from less than one second to several minutes. GRBs have been found to be situated at extremely large ("cosmological") distances. The energy released in a few seconds during such an event is larger than that of the Sun during its entire lifetime of more than 10,000 million years. The GRBs are indeed the most powerful events since the Big Bang known in the Universe, cf. ESO PR 08/99 and ESO PR 20/00. During the past years circumstantial evidence has mounted that GRBs signal the collapse of extremely massive stars, the so-called hypernovae. This was finally demonstrated some months ago when astronomers, using the FORS instrument on ESO's Very Large Telescope (VLT), documented in unprecedented detail the changes in the spectrum of the light source ("the optical afterglow") of the gamma-ray burst GRB 030329 (cf. ESO PR 16/03). A conclusive and direct link between cosmological gamma-ray bursts and explosions of very massive stars was provided on this occasion. Gamma-Ray Burst GRB 030329 was discovered on March 29, 2003 by NASA's High Energy Transient Explorer spacecraft. Follow-up observations with the UVES spectrograph at the 8.2-m VLT KUEYEN telescope at the Paranal Observatory (Chile) showed the burst to have a redshift of 0.1685 [1]. This corresponds to a distance of about 2,650 million light-years, making GRB 030329 the second-nearest long-duration GRB ever detected. The proximity of GRB 030329 resulted in very bright afterglow emission, permitting the most extensive follow-up observations of any afterglow to date. A team of astronomers [2] led by Jochen Greiner of the Max-Planck-Institut für extraterrestrische Physik (Germany) decided to make use of this unique opportunity to study the

  14. The Rubens Tube: A Flaming Good Way to Teach Waves

    Science.gov (United States)

    Sandoval, Christopher

    2013-01-01

    The Ruben Flame Tube is named after H. Ruben, who published the demonstration experiment in "Annalen der Physik" in 1905. This article presents one of the many demonstrations the author uses to engage, motivate, and challenge his students.

  15. Oesterreich im CERN - Interviews mit Oesterreicher arbeitet im CERN

    CERN Multimedia

    2009-01-01

    Robert Froeschl - Doktorant arbeitet am ATLAS EM calorimeter Martin Aleksa - physiker der am ATLAS Detector System arbeitet Bettina Mikulec - Strahlen Arbeitsgruppe Claudia Wulz - CMS experiment Michael Doser - Spokesperson of the AEGIS experiment

  16. Oesterreich im CERN

    CERN Multimedia

    CERN Audiovisual Service; Press Office

    2009-01-01

    Robert Froeschl - Doktorant arbeitet am ATLAS EM calorimeter Martin Aleksa - physiker der am ATLAS Detector System arbeitet Bettina Mikulec - Strahlen Arbeitsgruppe Claudia Wulz - CMS experiment Michael Doser - Spokesperson of the AEGIS experiment

  17. Newtons Principia Mathematica Philosophia und Plancks Elementarkonstanten

    Science.gov (United States)

    Rompe, R.; Treder, H.-J.

    Die Newtonschen Prinzipien, zusammen mit den Planckschen Elementarkonstanten, erweisen sich als gesichertes Fundament der Physik und der exakten Wissenschaften aller Richtungen.Der Begriffsfundus der Physik ist ausreichend für alle physikalischen aber auch weiterreichenden Probleme anderer Naturwissenschaften und Technik. Es zeigt sich, daß die klassische Physik von vornherein so angelegt wurde, daß sie über die Physik der makroskopischen Körper weit hinaus-greifen kann.Translated AbstractNewton's Principia Mathematica Philosophia and Planck's Elementary ConstantsTogether with Planck's elementary constants Newton's principles prove a guaranteed basis of physics and exact sciences of all directions.The conceptions in physics are competent at all physical problems as well as technology too. Classical physics was founded in such a way to reach far beyond the physics of macroscopic bodies.

  18. Multiprofessional education to stimulate collaboration: a circular argument and its consequences [

    Directory of Open Access Journals (Sweden)

    Roodbol, Petrie F.

    2010-04-01

    Full Text Available [english] The current developments in healthcare are unprecedented. The organization of health care is complex. Collaboration is essential to meet all the healthcare needs of patients and to achieve coordinated and unambiguous information. Multiprofessional education (MPE or multidisciplinary training (MDT seems a logical step to stimulate teamwork. However, collaboration and MPE are wrestling with the same problems: social identity and acceptance.

  19. Både ingeniører og humanister

    DEFF Research Database (Denmark)

    Hansen, Per H.

    2013-01-01

    DI er i gang med at udkæmpe den forrige krig, hvis de tror, at det kun er ingeniører, der kan sikre fremtidens Danmark.......DI er i gang med at udkæmpe den forrige krig, hvis de tror, at det kun er ingeniører, der kan sikre fremtidens Danmark....

  20. NCBI nr-aa BLAST: CBRC-LAFR-01-0196 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0196 ref|YP_001019338.1| hypothetical protein Mpe_A0141 [Methylibium petrol...eiphilum PM1] gb|ABM93103.1| hypothetical protein Mpe_A0141 [Methylibium petroleiphilum PM1] YP_001019338.1 0.30 33% ...

  1. Market Power Europe

    DEFF Research Database (Denmark)

    Kelstrup, Jesper Dahl

    2015-01-01

    Market Power Europe (MPE) constitutes an important contribution to the literature on the global role and actorness of the EU. In order to develop MPE as a theory, this contribution provides an assessment of how Russia, the USA and China have converged towards three EU trade policies in 2013...

  2. Proceedings of a Symposium on Perspectives in Fluid Mechanics Held in Pasadena, California on 10-12 January 1985

    Science.gov (United States)

    1988-07-29

    Research fflsti~ute for Mathematical Sciences, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606, Japan J. Ehlers, MP! kf& Physik und Astrophysik ...InstituL f~ir Astrophysik , Karl-Schwarzschild-StraBo 1, D-8046 Garching 1K. Hepp, ;nstitut fur Theoretische Physik, ETH, CH-8093 Zbrich R. Kppenhahn...MPi fijr Physilk und Astrophysik , Institut f(Jr Astrophysik , Karl’ Schwarzschild-Stra~e 1,,0-8046 D. Ruele, Institut des~ Hauwes Etudes

  3. Manual of Documentation Practices Applicable to Defence-Aerospace Scientific and Technical Information. Volume 1. Section 1 - Acquisition and Sources. Section 2 - Descriptive Cataloguing. Section 3 - Abstracting and Subject Analysis

    Science.gov (United States)

    1978-08-01

    copies and filing a copy under each of several headings in a dictionary catalog carQ file. An alternative is to subscribe to Library :)f Congress capds...Foods. histitut flier Theoretische Physik , Graz (Austria). &e Graz Univ. (Austria). Institut 11te, Theorctischo Phyvsik. Laboratoire do Ciuimle...da Forca Aerea c/o Fachmnformationszentrum Energie, Rua da Escola Politecmca 42 Physik , Mathematik GmbH Lisboa Kernforschungszentrum Attn. AGARD

  4. Microwave Processing of Materials

    Science.gov (United States)

    1994-01-01

    Pennsylvania: Materials Research Society. Wagner, C., and W. Schottky. 1930. Zeitschrift fuer Physikalische Chemie. BL11:163. Walkiewicz, J. W., A. E. Clark...Science and Engineering. 66:468--469. Bloch, F. 1928. Zeitschrift fuer Physik. 52:555. Boch, P., N. Lequeux and P. Piluso. 1992. Reaction Sintering...Frankel, J. 1926. Zeitschrift fuer Physik. 35:652. Fukushima, H., T. Yamaka, and M. Matsui. 1990. Microwave Heating of Ceramics and its Application to

  5. Thermal Conductivity of Metals and Alloys at Low Temperatures: A Review of the Literature

    Science.gov (United States)

    1954-09-01

    Do (1so) 48%C Gie. 6e0i 0R,2 b................D.E.G.S-8.7S,3. d Vr ad . 13%A Sb.r H0% Bi.F’.Ne eje N9%A Sb.T ~29 ---- SUPER~ "Roesmetl’B. remean...II, Z. physik. Chem. 125, Ann. Physik. 29, 597-604 (1937). 211-228 (1927). E. Grfineisen and H. Adenstedt. Eirfluss transversaler A. Eucken and

  6. International Symposium on Correlation and Polarization in Electron-Atom Collisions Held in Pasadena, California on 1-2 August 1985.

    Science.gov (United States)

    1985-08-02

    BRAZIL Dr. Peter Nass lst. Fur Physik Der Johannes Gutenberg - Universitat Postfach 3980 D-6500 Mainz Federal Republic of Germany Dr. P. Neill Department... Johannes Gutenberg - Universitat Postfach 3980 D-6500 Mainz Federal Republic of Germany -6- Dr. John Riley Department of Physics Flinders University...Rudge The Queens University of Belfast Belfast BT7 iNN NORTHERN IRELAND Dr. W. Sandner Fakultat fur Physik Universitat Freiburg Hermann- Herder -Str

  7. Globale Entwikclung als Lernbereich in den Naturwissenschaften

    OpenAIRE

    Härtig, Hendrik; Bernholt, Sascha; Schroeter, Burkhard

    2014-01-01

    Mit dem Orientierungsrahmen für den Lernbereich Globale Entwicklung wurden Anregungen gegeben, die Themen nachhaltige Entwicklung und globale Entwicklung im Unterricht in allen Schulfächern aufzugreifen. Die drei naturwissenschaftlichen Schulfächer Biologie, Chemie und Physik haben sich bislang sehr unterschiedlich auf das Thema eingelassen. In der Biologiedidaktik finden sich sowohl Forschungsarbeiten als auch Unterrichtsvorschläge; für Chemie und insbesondere Physik existieren hingegen nur ...

  8. Advance of Therapeutic Methods for Malignant Pleural Effusion

    Institute of Scientific and Technical Information of China (English)

    XU Tao-tao

    2016-01-01

    Malignant pleural effusion (MPE) is a condition caused by primary malignant tumors in the pleura or other malignant tumors metastasis to the pleura. It is also one of common serious complications of middle-late malignant tumor, which has severe impact on the quality of life, even threatening the life of the patients. The selection of treatments for MPE depends on many factors, including the symptoms, performance status, primary tumor types, response to systemic therapy, and degree of lung recruitment maneuvers (LRM) after drainage of pleural effusion. Generally, the treatment methods include thoracentesis, indwelling pleural catheter, pleurodesis, intrapleural injection of drugs, chemotherapy, radiotherapy, anti-angiogenesis therapy, surgery, and thermotherapy. With the in-depth study on pathogenesis of MPE, the treatments of MPE have continuous improvements. This study mainly reviewed the treatment methods for MPE so as to provide the basis for clinical practice in the future.

  9. Nutritional and sensory quality evaluation of sponge cake prepared by incorporation of high dietary fiber containing mango (Mangifera indica var. Chokanan) pulp and peel flours.

    Science.gov (United States)

    Aziah, A A Noor; Min, W Lee; Bhat, Rajeev

    2011-09-01

    Sponge cake prepared by partial substitution of wheat flour with mango pulp and mango peel flours (MPuF and MPeF, respectively) at different concentrations (control, 5%, 10%, 20% or 30%) were investigated for the physico-chemical, nutritional and organoleptic characteristics. Results showed sponge cake incorporated with MPuF and MPeF to have high dietary fiber with low fat, calorie, hydrolysis and predicted glycemic index compared with the control. Increasing the levels of MPuF and MPeF in sponge cake had significant impact on the volume, firmness and color. Sensory evaluation showed sponge cake formulated with 10% MPuF and 10% MPeF to be the most acceptable. MPeF and MPuF have high potential as fiber-rich ingredients and can be utilized in the preparation of cake and other bakery products to improve the nutritional qualities.

  10. Advance of Therapeutic Methods for Malignant Pleural Effusion

    Directory of Open Access Journals (Sweden)

    Tao-tao XU

    2016-06-01

    Full Text Available Malignant pleural effusion (MPE is a condition caused by primary malignant tumors in the pleura or other malignant tumors metastasis to the pleura. It is also one of common serious complications of middle-late malignant tumor, which has severe impact on the quality of life, even threatening the life of the patients. The selection of treatments for MPE depends on many factors, including the symptoms, performance status, primary tumor types, response to systemic therapy, and degree of lung recruitment maneuvers (LRM after drainage of pleural effusion. Generally, the treatment methods include thoracentesis, indwelling pleural catheter, pleurodesis, intrapleural injection of drugs, chemotherapy, radiotherapy, anti-angiogenesis therapy, surgery, and thermotherapy. With the in-depth study on pathogenesis of MPE, the treatments of MPE have continuous improvements. This study mainly reviewed the treatment methods for MPE so as to provide the basis for clinical practice in the future.

  11. Is This Speck of Light an Exoplanet?

    Science.gov (United States)

    2004-09-01

    ). A preprint is available here and also as astro-ph0409323. Notes [1]: This press release is issued simultaneously by ESO and CNRS (in French). [2]: The team consists of Gael Chauvin and Christophe Dumas (ESO-Chile), Anne-Marie Lagrange and Jean-Luc Beuzit (LAOG, Grenoble, France), Benjamin Zuckerman and Inseok Song (UCLA, Los Angeles, USA), David Mouillet (LAOMP, Tarbes, France) and Patrick Lowrance (IPAC, Pasadena, USA). The American members of the team acknowledge funding in part by NASA's Astrobiology Institute. [3]: The NACO facility (from NAOS/Nasmyth Adaptive Optics System and CONICA/Near-Infrared Imager and Spectrograph) at the 8.2-m VLT Yepun telescope on Paranal offers the capability to produce diffraction-limited near-infrared images of astronomical objects. It senses the radiation in this wavelength region with the N90C10 dichroic; 90 percent of the flux is transmitted to the wavefront sensor and 10 percent to the near-infrared camera CONICA. This mode is particularly useful for sharp imaging of red and very-low-mass stellar or substellar objects. The adaptive optics corrector (NAOS) was built, under an ESO contract, by Office National d'Etudes et de Recherches Aérospatiales (ONERA), Laboratoire d'Astrophysique de Grenoble (LAOG) and the LESIA and GEPI laboratories of the Observatoire de Paris in France, in collaboration with ESO. The CONICA camera was built, under an ESO contract, by the Max-Planck-Institut für Astronomie (MPIA) (Heidelberg) and the Max-Planck Institut für extraterrestrische Physik (MPE) (Garching) in Germany, in collaboration with ESO. [4]: What is the difference between a small brown dwarf and an exoplanet ? The border line between the two is still being investigated but it appears that a brown dwarf object is formed in the same way as stars, i.e. by contraction in an interstellar cloud while planets are formed within stable circumstellar disks via collision/accretion of planetesimals or disk instabilities. This implies that brown

  12. Beneficial impact of CCL2 and CCL12 neutralization on experimental malignant pleural effusion.

    Directory of Open Access Journals (Sweden)

    Antonia Marazioti

    Full Text Available Using genetic interventions, we previously determined that C-C motif chemokine ligand 2 (CCL2 promotes malignant pleural effusion (MPE formation in mice. Here we conducted preclinical studies aimed at assessing the specific therapeutic potential of antibody-mediated CCL2 blockade against MPE. For this, murine MPEs or skin tumors were generated in C57BL/6 mice by intrapleural or subcutaneous delivery of lung (LLC or colon (MC38 adenocarcinoma cells. Human lung adenocarcinoma cells (A549 were used to induce MPEs in severe combined immunodeficient mice. Intraperitoneal antibodies neutralizing mouse CCL2 and/or CCL12, a murine CCL2 ortholog, were administered at 10 or 50 mg/kg every three days. We found that high doses of CCL2/12 neutralizing antibody treatment (50 mg/kg were required to limit MPE formation by LLC cells. CCL2 and CCL12 blockade were equally potent inhibitors of MPE development by LLC cells. Combined CCL2 and CCL12 neutralization was also effective against MC38-induced MPE and prolonged the survival of mice in both syngeneic models. Mouse-specific CCL2-blockade limited A549-caused xenogeneic MPE, indicating that host-derived CCL2 also contributes to MPE precipitation in mice. The impact of CCL2/12 antagonism was associated with inhibition of immune and vascular MPE-related phenomena, such as inflammation, new blood vessel assembly and plasma extravasation into the pleural space. We conclude that CCL2 and CCL12 blockade are effective against experimental MPE induced by murine and human adenocarcinoma in mice. These results suggest that CCL2-targeted therapies may hold promise for future use against human MPE.

  13. Multiple Payload Ejector for Education, Science and Technology Experiments

    Science.gov (United States)

    Lechworth, Gary

    2005-01-01

    The education research community no longer has a means of being manifested on Space Shuttle flights, and small orbital payload carriers must be flown as secondary payloads on ELV flights, as their launch schedule, secondary payload volume and mass permits. This has resulted in a backlog of small payloads, schedule and cost problems, and an inability for the small payloads community to achieve routine, low-cost access to orbit. This paper will discuss Goddard's Wallops Flight Facility funded effort to leverage its core competencies in small payloads, sounding rockets, balloons and range services to develop a low cost, multiple payload ejector (MPE) carrier for orbital experiments. The goal of the MPE is to provide a low-cost carrier intended primarily for educational flight research experiments. MPE can also be used by academia and industry for science, technology development and Exploration experiments. The MPE carrier will take advantage of the DARPAI NASA partnership to perform flight testing of DARPA s Falcon small, demonstration launch vehicle. The Falcon is similar to MPE fiom the standpoint of focusing on a low-cost, responsive system. Therefore, MPE and Falcon complement each other for the desired long-term goal of providing the small payloads community with a low-cost ride to orbit. The readiness dates of Falcon and MPE are complementary, also. MPE is being developed and readied for flight within 18 months by a small design team. Currently, MPE is preparing for Critical Design Review in fall 2005, payloads are being manifested on the first mission, and the carrier will be ready for flight on the first Falcon demonstration flight in summer, 2006. The MPE and attached experiments can weigh up to 900 lb. to be compatible with Falcon demonstration vehicle lift capabilities fiom Wallops, and will be delivered to the Falcon demonstration orbit - 100 nautical mile circular altitude.

  14. Palliative Treatment of Malignant Pleural Effusion

    Directory of Open Access Journals (Sweden)

    Chenyang Liu

    2015-01-01

    Full Text Available Malignant pleural effusion (MPE is a common clinical problem caused by cancers. Pleural effusion can be the first sign of cancer in more than 25% of patients. Lung cancer and breast cancer are the most common cancers that metastasize to the pleura in men and women, respectively. Other cancers, including, but not limited to, lymphomas, ovarian cancer, stomach cancer, and several unknown primary cancers can also lead to MPE. Dyspnea and chest pain are the most common symptoms of MPE along with other symptoms such as a cough, weight loss, anorexia, fatigue, and weakness. Aggravation of these symptoms is closely related to the rate of accumulation of pleural effusion. Treatment options to MPE are determined by the type and extent of the underlying malignancy. The major goals of the treatment are to relieve symptoms, restore functions, improve the quality of life, and minimize the duration of hospital stay and costs. Although some patients can be treated with systemic therapies, most of these treatments are temporary, and MPE would recur soon. Hence, further palliative treatments to effectively control pleural effusions and relieve symptoms are necessary. This review addresses the pathophysiology of MPE and the treatment options for patients with MPE.

  15. EMFR HRA of the Newport Antenna Measurement Facility

    Science.gov (United States)

    2015-07-15

    1600 has upper and lower transmit bays. The upper transmit bay houses four antennas, and the lower transmit bay houses three antennas. These...MPE at 73 feet in front of the antenna (2) Readings for the 6-foot antenna: • 5.0% of upper tier MPE within 1 foot of the ray dome • 50.0% of...lower tier MPE within 1 foot of the ray dome b. Evaluation of Engineering Control Measures: Various engineering controls are utilized to include key

  16. Nye veje i bandeindsatsen

    DEFF Research Database (Denmark)

    Krogh, Andreas Hagedorn; Torfing, Jacob

    2014-01-01

    Der er behov for at gentænke indsatsen over for kriminelle bander. De to forskere Andreas Hagedorn Krogh og Jacob Torfing fra Roskilde Universitet har undersøgt nye metoder til at bekæmpe banderne...

  17. El arrendamiento financiero y valuación de opciones reales

    National Research Council Canada - National Science Library

    Gastón Silverio Milanesi

    2016-01-01

    El trabajo estudia diferentes opciones reales simples y compuestas contenidas en los contratos de leasing, bajo una metodología que combina el método de préstamo equivalente (MPE) y opciones reales...

  18. Reconstruction of ionization probabilities from spatially averaged data in N-dimensions

    CERN Document Server

    Strohaber, J; Schuessler, H A

    2010-01-01

    We present an analytical inversion technique which can be used to recover ionization probabilities from spatially averaged data in an N-dimensional detection scheme. The solution is given as a power series in intensity. For this reason, we call this technique a multiphoton expansion (MPE). The MPE formalism was verified with an exactly solvable inversion problem in 2D, and probabilities in the postsaturation region, where the intensity-selective scanning approach breaks down, were recovered. In 3D, ionization probabilities of Xe were successfully recovered with MPE from simulated (using the ADK tunneling theory) ion yields. Finally, we tested our approach with intensity-resolved benzene ion yields showing a resonant multiphoton ionization process. By applying MPE to this data (which was artificially averaged) the resonant structure was recovered-suggesting that the resonance in benzene may have been observable in spatially averaged data taken elsewhere.

  19. Identification of the chlE gene encoding oxygen-independent Mg-protoporphyrin IX monomethyl ester cyclase in cyanobacteria.

    Science.gov (United States)

    Yamanashi, Kaori; Minamizaki, Kei; Fujita, Yuichi

    2015-08-07

    The fifth ring (E-ring) of chlorophyll (Chl) a is produced by Mg-protoporphyrin IX monomethyl ester (MPE) cyclase. There are two evolutionarily unrelated MPE cyclases: oxygen-independent (BchE) and oxygen-dependent (ChlA/AcsF) MPE cyclases. Although ChlA is the sole MPE cyclase in Synechocystis PCC 6803, it is yet unclear whether BchE exists in cyanobacteria. A BLAST search suggests that only few cyanobacteria possess bchE. Here, we report that two bchE candidate genes from Cyanothece strains PCC 7425 and PCC 7822 restore the photosynthetic growth and bacteriochlorophyll production in a bchE-lacking mutant of Rhodobacter capsulatus. We termed these cyanobacterial bchE orthologs "chlE."

  20. Talc Pleurodesis Through Very-Small-Bore Catheters in Patients with Recurrent Malignant Pleural Effusion

    Directory of Open Access Journals (Sweden)

    Ali Özgen

    2016-04-01

    Full Text Available Objective: Malignant pleural effusion (MPE is a frequent and disturbing complication of metastatic disease. Talc pleurodesis via percutaneosly placed 12–18F catheters is an effective procedure to treat recurrent MPE. We aimed to determine the efficiency of talc pleurodesis through very-small-bore catheters in the treatment of recurrent malignant pleural effusion. Methods: We performed 13 talc pleurodesis procedures in 10 patients with recurrent MPE via pre-existing 7F (6 patients and 8F (4 patients pig-tail catheters. We analyzed technical and clinical success of the procedure. Results: All procedures were performed successfully. Complete or partial clinical success was achieved in 8 out of 10 patients. No major complication was observed. Conclusion: Talc pleurodesis through 7F or 8F catheters may be performed in selected patients with reduced patient discomfort, and similar success rates that was obtained using higher caliber catheters in the treatment of recurrent MPE.

  1. A Water Extract of Mucuna pruriens Provides Long-Term Amelioration of Parkinsonism with Reduced Risk for Dyskinesias

    OpenAIRE

    Lieu, Christopher A; Kunselman, Allen R.; Manyam, Bala V.; Venkiteswaran, Kala; Subramanian, Thyagarajan

    2010-01-01

    Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of Mucuna pruriens seed powder (MPE) alone without any additives, MPE combined with the peripheral dopa-decar...

  2. Single center experience on talc poudrage morbidity: focus on high talc dosage

    Directory of Open Access Journals (Sweden)

    Congedo Maria

    2011-06-01

    Full Text Available Abstract Malignant pleural effusion (MPE is a common clinical problem of concern for most of the pneumologists and thoracic surgeons. A general consensus regarding the use of talc poudrage in treatment of MPE exists, but only few studies analyzed in detail talc insufflation related pulmonary morbidity. In particular, ARDS talc-related is caused by physical and chemical effects of the small talc particles (50% particle size

  3. Model order reduction for steady aerodynamics of high-lift configurations

    DEFF Research Database (Denmark)

    Vendl, Alexander; Faßbender, Heike; Goertz, Stefan

    2014-01-01

    In aerodynamic applications, many model reduction methods use proper orthogonal decomposition (POD). In this work, a POD-based method, called missing point estimation (MPE), is modified and applied to steady-state flows with variation of the angle of attack. The main idea of MPE is to select a su......-element high-lift airfoils, one which is normally adopted during landing and the other during take-off....

  4. A Novel Combination of Calprotectin and CXCL12 for Predicting Malignancy in Patients with Exudative Pleural Effusion.

    Science.gov (United States)

    Luo, Jian; Wang, Maoyun; Li, Chuntao; Liang, Binmiao; Liu, Dan; Shi, Chaoli; Jiang, Faming; Wang, Ting; Li, Peijun; Liang, Zongan

    2015-11-01

    Pleural effusion (PE) remains a significant challenge and public health problem, which needs novel noninvasive biomarkers for the precise diagnosis. The aim of this study was to further determine the clinical efficacy and diagnostic accuracy of a novel combination of calprotectin and CXCL12 for predicting malignancy in patients with exudative PE.Calprotectin and CXCL12 concentrations were measured in 95 individuals of exudative PE, with 39 malignant PE (MPE) and 56 benign PE (BPE). The accuracy of calprotectin and CXCL12 levels for discriminating MPE from BPE or tuberculous PE were evaluated using receiver-operating characteristic (ROC) curves. Univariate and multivariate logistic regression analyses were performed to test the association between calprotectin and CXCL12 levels and MPE.Calprotectin and CXCL12 levels of patients with MPE were significantly lower than that of BPE and tuberculous PE (P calprotectin and CXCL12 was 0.683 and 0.641 in MPE and BPE, and a combination of calprotectin ≤500.19 ng/mL and CXCL12 ≤6.11 ng/mL rendered a sensitivity and specificity of 48.72% and 78.57%, respectively. While in MPE and tuberculous PE, the AUC of calprotectin and CXCL12 was 0.696 and 0.690, and a combination of calprotectin ≤421.73 ng/mL and CXCL12 ≤3.71 ng/mL presented a sensitivity and specificity of 25.64% and 95.45%, respectively. Multivariate logistic regression demonstrated that both calprotectin and CXCL12 were independent predictors of MPE.Calprotectin and CXCL12 in pleural fluid are informative diagnostic biomarkers for predicting patients with MPE.

  5. Mucuna pruriens (Velvet bean rescues motor, olfactory, mitochondrial and synaptic impairment in PINK1B9 Drosophila melanogaster genetic model of Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Simone Poddighe

    Full Text Available The fruit fly Drosophila melanogaster (Dm mutant for PTEN-induced putative kinase 1 (PINK1B9 gene is a powerful tool to investigate physiopathology of Parkinson's disease (PD. Using PINK1B9 mutant Dm we sought to explore the effects of Mucuna pruriens methanolic extract (Mpe, a L-Dopa-containing herbal remedy of PD. The effects of Mpe on PINK1B9 mutants, supplied with standard diet to larvae and adults, were assayed on 3-6 (I, 10-15 (II and 20-25 (III days old flies. Mpe 0.1% significantly extended lifespan of PINK1B9 and fully rescued olfactory response to 1-hexanol and improved climbing behavior of PINK1B9 of all ages; in contrast, L-Dopa (0.01%, percentage at which it is present in Mpe 0.1% ameliorated climbing of only PINK1B9 flies of age step II. Transmission electron microscopy analysis of antennal lobes and thoracic ganglia of PINK1B9 revealed that Mpe restored to wild type (WT levels both T-bars and damaged mitochondria. Western blot analysis of whole brain showed that Mpe, but not L-Dopa on its own, restored bruchpilot (BRP and tyrosine hydroxylase (TH expression to age-matched WT control levels. These results highlight multiple sites of action of Mpe, suggesting that its effects cannot only depend upon its L-Dopa content and support the clinical observation of Mpe as an effective medication with intrinsic ability of delaying the onset of chronic L-Dopa-induced long-term motor complications. Overall, this study strengthens the relevance of using PINK1B9 Dm as a translational model to study the properties of Mucuna pruriens for PD treatment.

  6. Pleural LDH as a prognostic marker in adenocarcinoma lung with malignant pleural effusion

    OpenAIRE

    Verma, Akash; Phua, Chee Kiang; Sim, Wen Yuan; Algoso, Reyes Elmer; Tee, Kuan Sen; Lew, Sennen J. W.; Lim, Albert Y.H.; Goh, Soon Keng; Tai, Dessmon Y. H.; Kor, Ai Ching; Ho, Benjamin; Abisheganaden, John

    2016-01-01

    Abstract To study the performance of serum and pleural lactate dehydrogenase (LDH) level in predicting survival in patients with adenocarcinoma lung presenting with malignant pleural effusions (MPE) at initial diagnosis. Retrospective cohort study of the patient hospitalized for adenocarcinoma lung with MPE in year 2012. Univariate analyses showed lower pleural fluid LDH 667 (313–967) versus 971 (214–3800), P = 0.04, female gender 9 (100%) versus 27 (41.5%), P = 0.009, never smoking status 9 ...

  7. Quantenfeldtheorie wie man beschreibt, was die Welt im Innersten zusammenhält

    CERN Document Server

    Fritzsch, Harald

    2015-01-01

    Die Geheimnisse des Mikrokosmos aufzudecken, hat die Physiker seit Jahrhunderten fasziniert. Doch obwohl in den vergangenen Jahrzehnten viele interessante Entdeckungen gemacht wurden, bleiben noch Fragen offen, die Harald Fritzsch in diesem Buch von der physikalischen und mathematischen Seite beleuchtet: - Haben die Physiker mit der Standardtheorie der Elementarteilchenphysik schon eine exakte Beschreibung der Teilchenwelt gefunden? - Gibt es wirklich eine „Große Vereinigung“ aller fundamentalen Kräfte? - Und sind die Leptonen, (wie das Elektron), oder die Bausteine der Hadronen, (die Quarks), vielleicht gar nicht wirklich punktförmig, sondern kleine eindimensionale Objekte, die man als „Strings“ bezeichnet? Dieses Buch setzt mathematische Vorbildung voraus und versteht sich als Überblick über die modernen Grundlagen der Quantenfeldtheorie und als Diskussionsbeitrag. Somit eignet sich das Werk insbesondere auch als Überblick und Wiederholung für Physiker. Harald Fritzsch ist bereits als Auto...

  8. Physikdidaktik Theorie und Praxis

    CERN Document Server

    Girwidz, Raimund; Häußler, Peter

    2015-01-01

    „Physikdidaktik – Theorie und Praxis“ ist ein Sammelband, der dynamisch gewachsen ist. Der Teil I wurde im Jahre 2000 in erster Linie für Studierende des Lehramts Physik konzipiert. Der Teil II zeigt Konkretisierungen und im Unterricht erprobte Beispiele zu neueren didaktischen und methodischen Ansätzen, die aus der Pädagogik und der allgemeinen Didaktik für die Physikdidaktik aufbereitet wurden. Die Physikdidaktik befasst sich natürlich auch mit der Frage, welche Elemente aus der modernen Physik in den Unterricht eingehen können und sollen. Vor der Aufbereitung der Inhalte für den Unterricht, mit Vereinfachungen und angemessenen didaktischen Reduktionen, steht die Sachanalyse und die Zusammenfassung von interessanten Themen aus aktuellen experimentellen und theoretischen Arbeitsgebieten der Physik (Teil III). In der vorliegenden 3. Ausgabe eines Gesamtbandes „Physikdidaktik – Theorie und Praxis“ wurden Astrophysik, Elementar­teilchenphysik und Biophysik als interessante Beispiele aus ...

  9. 3-MCPD 1-Palmitate Induced Tubular Cell Apoptosis In Vivo via JNK/p53 Pathways.

    Science.gov (United States)

    Liu, Man; Huang, Guoren; Wang, Thomas T Y; Sun, Xiangjun; Yu, Liangli Lucy

    2016-05-01

    Fatty acid esters of 3-chloro-1, 2-propanediol (3-MCPD esters) are a group of processing induced food contaminants with nephrotoxicity but the molecular mechanism(s) remains unclear. This study investigated whether and how the JNK/p53 pathway may play a role in the nephrotoxic effect of 3-MCPD esters using 3-MCPD 1-palmitate (MPE) as a probe compound in Sprague Dawley rats. Microarray analysis of the kidney from the Sprague Dawley rats treated with MPE, using Gene Ontology categories and KEGG pathways, revealed that MPE altered mRNA expressions of the genes involved in the mitogen-activated protein kinase (JNK and ERK), p53, and apoptotic signal transduction pathways. The changes in the mRNA expressions were confirmed by qRT-PCR and Western blot analyses and were consistent with the induction of tubular cell apoptosis as determined by histopathological, TUNEL, and immunohistochemistry analyses in the kidneys of the Sprague Dawley rats. Additionally, p53 knockout attenuated the apoptosis, and the apoptosis-related protein bax expression and cleaved caspase-3 activation induced by MPE in the p53 knockout C57BL/6 mice, whereas JNK inhibitor SP600125 but not ERK inhibitor U0126 inhibited MPE-induced apoptosis, supporting the conclusion that JNK/p53 might play a critical role in the tubular cell apoptosis induced by MPE and other 3-MCPD fatty acid esters.

  10. Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice.

    Science.gov (United States)

    Prasad, Sahdeo; Kalra, Neetu; Shukla, Yogeshwer

    2007-03-01

    Lupeol, a triterpene present in mango and other fruits, is known to exhibit a number of pharmacological properties including antioxidant, antilithiatic, and antidiabetic effects. In the present study, chemopreventive properties of lupeol and mango pulp extract (MPE) were evaluated against 7,12-dimethylbenz(a)anthracene (DMBA) induced alteration in liver of Swiss albino mice. Lupeol (25 mg/kg body weight, bw) or 1 mL of 20% w/v aqueous MPE/mouse were daily given once for 1 wk after a single dose of DMBA (50 mg/kg bw). Lupeol/MPE supplementation effectively influenced the DMBA induced oxidative stress, characterized by restored antioxidant enzyme activities and decrease in lipid peroxidation. A reduction of apoptotic cell population in the hypodiploid region was observed in lupeol and MPE supplemented animals. The inhibition of apoptosis was preceded by decrease in reactive oxygen species (ROS) level and restoration of mitochondrial transmembrane potential followed by decreased DNA fragmentation. In DMBA treated animals, downregulation of antiapoptotic Bcl-2 and upregulation of proapoptotic Bax and Caspase 3 in mouse liver was observed. These alterations were restored by lupeol/MPE, indicating inhibition of apoptosis. Thus, lupeol/MPE was found to be effective in combating oxidative stress induced cellular injury of mouse liver by modulating cell-growth regulators.

  11. Effect of Mucuna pruriens Seed Extract Pretreatment on the Responses of Spontaneously Beating Rat Atria and Aortic Ring to Naja sputatrix (Javan Spitting Cobra) Venom.

    Science.gov (United States)

    Fung, Shin Yee; Tan, Nget Hong; Sim, Si Mui; Aguiyi, John C

    2012-01-01

    Mucuna pruriens Linn. (velvet bean) has been used by native Nigerians as a prophylactic for snakebite. Rats pretreated with M. pruriens seed extract (MPE) have been shown to protect against the lethal and cardiovascular depressant effects of Naja sputatrix (Javan spitting cobra) venoms, and the protective effect involved immunological neutralization of the venom toxins. To investigate further the mechanism of the protective effect of MPE pretreatment against cobra venom toxicity, the actions of Naja sputatrix venom on spontaneously beating rat atria and aortic rings isolated from both MPE pretreated and untreated rats were studied. Our results showed that the MPE pretreatment conferred protection against cobra venom-induced depression of atrial contractility and atrial rate in the isolated atrial preparations, but it had no effect on the venom-induced contractile response of aortic ring preparation. These observations suggested that the protective effect of MPE pretreatment against cobra venom toxicity involves a direct protective action of MPE on the heart function, in addition to the known immunological neutralization mechanism, and that the protective effect does not involve action on blood vessel contraction. The results also suggest that M. pruriens seed may contain novel cardioprotective agent with potential therapeutic value.

  12. Effect of Mucuna pruriens Seed Extract Pretreatment on the Responses of Spontaneously Beating Rat Atria and Aortic Ring to Naja sputatrix (Javan Spitting Cobra Venom

    Directory of Open Access Journals (Sweden)

    Shin Yee Fung

    2012-01-01

    Full Text Available Mucuna pruriens Linn. (velvet bean has been used by native Nigerians as a prophylactic for snakebite. Rats pretreated with M. pruriens seed extract (MPE have been shown to protect against the lethal and cardiovascular depressant effects of Naja sputatrix (Javan spitting cobra venoms, and the protective effect involved immunological neutralization of the venom toxins. To investigate further the mechanism of the protective effect of MPE pretreatment against cobra venom toxicity, the actions of Naja sputatrix venom on spontaneously beating rat atria and aortic rings isolated from both MPE pretreated and untreated rats were studied. Our results showed that the MPE pretreatment conferred protection against cobra venom-induced depression of atrial contractility and atrial rate in the isolated atrial preparations, but it had no effect on the venom-induced contractile response of aortic ring preparation. These observations suggested that the protective effect of MPE pretreatment against cobra venom toxicity involves a direct protective action of MPE on the heart function, in addition to the known immunological neutralization mechanism, and that the protective effect does not involve action on blood vessel contraction. The results also suggest that M. pruriens seed may contain novel cardioprotective agent with potential therapeutic value.

  13. Protective effects of lupeol against benzo[a]pyrene induced clastogenicity in mouse bone marrow cells.

    Science.gov (United States)

    Prasad, Sahdeo; Kumar Yadav, Vinay; Srivastava, Smita; Shukla, Yogeshwer

    2008-10-01

    Fruits and vegetables contain a variety of ingredients that exhibit chemopreventive effects against an array of xenobiotics. In the present study, the antigenotoxic potential of lupeol, a triterpene, and mango pulp extract (MPE) was evaluated in Swiss albino mice. Benzo[a]pyrene (B[a]P), a well-known mutagen, was given at a single dose of 100 mg/kg body weight intraperitoneally. Pretreatment with lupeol (1 mg/animal) and MPE (1 mL, 20%) was given through oral intubation for 7 days prior to B[a]P administration. Animals from all the groups were killed at sampling time of 24 h and their bone marrow tissue was analyzed for chromosomal damage and micronuclei induction. In B[a]P-treated animals a significant induction of chromosomal aberration and micronuclei was recorded, with a decrease in mitotic index. In lupeol- or MPE-supplemented groups, a significant decrease in B[a]P-induced clastogenicity was recorded. The incidence of aberrant cells and micronuclei was found to be reduced by both lupeol and MPE when compared to the B[a]P-treated group. The anti-cytotoxic effects of lupeol or MPE were also evident, as observed by significant increase in mitotic index. Thus, results of the present investigation revealed that lupeol and MPE have protective effects against B[a]P-induced clastogenic changes in Swiss albino mice.

  14. Mast cells mediate malignant pleural effusion formation

    Science.gov (United States)

    Giannou, Anastasios D.; Marazioti, Antonia; Spella, Magda; Kanellakis, Nikolaos I.; Apostolopoulou, Hara; Psallidas, Ioannis; Prijovich, Zeljko M.; Vreka, Malamati; Zazara, Dimitra E.; Lilis, Ioannis; Papaleonidopoulos, Vassilios; Kairi, Chrysoula A.; Patmanidi, Alexandra L.; Giopanou, Ioanna; Spiropoulou, Nikolitsa; Harokopos, Vaggelis; Aidinis, Vassilis; Spyratos, Dionisios; Teliousi, Stamatia; Papadaki, Helen; Taraviras, Stavros; Snyder, Linda A.; Eickelberg, Oliver; Kardamakis, Dimitrios; Iwakura, Yoichiro; Feyerabend, Thorsten B.; Rodewald, Hans-Reimer; Kalomenidis, Ioannis; Blackwell, Timothy S.; Agalioti, Theodora; Stathopoulos, Georgios T.

    2015-01-01

    Mast cells (MCs) have been identified in various tumors; however, the role of these cells in tumorigenesis remains controversial. Here, we quantified MCs in human and murine malignant pleural effusions (MPEs) and evaluated the fate and function of these cells in MPE development. Evaluation of murine MPE-competent lung and colon adenocarcinomas revealed that these tumors actively attract and subsequently degranulate MCs in the pleural space by elaborating CCL2 and osteopontin. MCs were required for effusion development, as MPEs did not form in mice lacking MCs, and pleural infusion of MCs with MPE-incompetent cells promoted MPE formation. Once homed to the pleural space, MCs released tryptase AB1 and IL-1β, which in turn induced pleural vasculature leakiness and triggered NF-κB activation in pleural tumor cells, thereby fostering pleural fluid accumulation and tumor growth. Evaluation of human effusions revealed that MCs are elevated in MPEs compared with benign effusions. Moreover, MC abundance correlated with MPE formation in a human cancer cell–induced effusion model. Treatment of mice with the c-KIT inhibitor imatinib mesylate limited effusion precipitation by mouse and human adenocarcinoma cells. Together, the results of this study indicate that MCs are required for MPE formation and suggest that MC-dependent effusion formation is therapeutically addressable. PMID:25915587

  15. Three-Dimensional Properties of Coronal Mass Ejections from STEREO/SECCHI Observations

    Science.gov (United States)

    2012-01-01

    astro.physik.uni-goettingen.de V. Bothmer e-mail: bothmer@astro.physik.uni-goettingen.de G. Nisticò Dipartimento di Fisica , Universita della Calabria...and monthly smoothed sunspot numbers show generally similar trends but not detailed correlations as has been reported in earlier studies (e.g., St. Cyr...summarized in Table 2. The synthetic coronagraphic images generated with a ray-tracing code are shown in Fig- ure 5. The ray-tracing code allows us to

  16. Research and Development of Methods for Estimating Physicochemical Properties of Organic Compounds of Environmental Concern. Part 2.

    Science.gov (United States)

    1981-06-01

    Parachor and Molar Refraction," Chem. Eng. Prog.,45, 149-53 (1949). 12-54 I Arthur 1) Little. Inc 16I 15. Michels, W.C. (ed.), The International Dictionary ...Complex- ity of Solvents," Z. physik . Chem., 65, 129-225 (1909). 11. Weast, R.C. and M.J. Astle (eds.), Handbook of Chemistry and Physics, 60th ed...F., "A New Calculation of Atomic Refractions," Z. Physik Chem., 75, 585-607 (1910). 2. Gold, P.I. and G.J. Ogle, "Estimating Thermophysica

  17. Infrared Images of an Infant Solar System

    Science.gov (United States)

    2002-05-01

    . Grosso and co-authors). Notes [1]: The team consists of Nicolas Grosso (Max-Planck-Institut für extraterrestrische Physik, Garching, Germany), João Alves (ESO, Garching, Germany), Kenneth Wood (School of Physics & Astronomy, University of St Andrews, Scotland, UK), Ralph Neuhäuser (Max-Planck-Institut für extraterrestrische Physik, Garching, Germany), Thierry Montmerle (Service d'Astrophysique, CEA Saclay,Gif-sur-Yvette, France) and Jon E. Bjorkman (Ritter Observatory, Department of Physics & Astronomy, University of Toledo, Ohio, USA).

  18. A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias.

    Science.gov (United States)

    Lieu, Christopher A; Kunselman, Allen R; Manyam, Bala V; Venkiteswaran, Kala; Subramanian, Thyagarajan

    2010-08-01

    Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M. pruriens seed powder (MPE) alone without any additives, MPE combined with the peripheral dopa-decarboxylase inhibitor (DDCI) benserazide (MPE+BZ), LD+BZ and LD alone without BZ in the hemiparkinsonian rat model of PD. A battery of behavioral tests assessed by blinded investigators served as outcome measures in these randomized trials. In experiment 1, animals that received LD+BZ or MPE+BZ at high (6mg/kg) and medium (4mg/kg) equivalent doses demonstrated significant alleviation of parkinsonism, but, developed severe dose-dependent DID. LD+BZ at low doses (2mg/kg) did not provide significant alleviation of parkinsonism. In contrast, MPE+BZ at an equivalent low dose significantly ameliorated parkinsonism. In experiment 2, MPE without any additives (12mg/kg and 20mg/kg LD equivalent dose) alleviated parkinsonism with significantly less DID compared to LD+BZ or MPE+BZ. In experiment 3, MPE without additives administered chronically provided long-term anti-parkinsonian benefits without causing DID. In experiment 4, MPE alone provided significantly more behavioral benefit when compared to the equivalent dose of synthetic LD alone without BZ. In experiment 5, MPE alone reduced the severity of DID in animals initially primed with LD+BZ. These findings suggest that M. pruriens contains water-soluble ingredients that either have an intrinsic DDCI-like activity or mitigate the need for an add-on DDCI to ameliorate parkinsonism. These unique long-term anti-parkinsonian effects of a parenterally administered water extract of M. pruriens seed powder may provide a platform for future drug

  19. Planet Formation in Action? - Astronomers may have found the first object clearing its path in the natal disc surrounding a young star

    Science.gov (United States)

    2011-02-01

    , astronomers can remove most of the blurring effect of the atmosphere and obtain very sharp images. The team used NACO in a novel way, called sparse aperture masking (SAM) to search for the companion. This is a type of interferometry that, rather than combining the light from multiple telescopes as the VLTI does, uses different parts of the mirror of a single telescope (in this case, the mirror of the VLT Unit Telescope 4). This new technique is particularly good for finding faint objects very close to bright ones. VLTI/AMBER is better suited to studying the structure of the inner disc and is less sensitive to the presence of a distant companion. [5] The astronomers searched for the companion using NACO in two different spectral bands - at around 2.2 microns and at 3.8 microns. The companion is only seen at the longer wavelength, which means that the object is either cool, like a planet, or a dust-shrouded brown dwarf. [6] Brown dwarfs are objects between stars and planets in size. They are not massive enough to fuse hydrogen in their cores but are larger than giant planets such as Jupiter. More information This research was presented in two papers: Olofsson et al. 2011, "Warm dust resolved in the cold disk around TCha with VLTI/AMBER", and Huélamo et al. 2011, "A companion candidate in the gap of the T Cha transitional disk", to appear in the journal Astronomy & Astrophysics. The team is composed of J. Olofsson (Max-Planck-Institut für Astronomie [MPIA], Heidelberg, Germany), M. Benisty (MPIA), J.-C. Augereau (Institut de Planétologie et d'Astrophysique de Grenoble [IPAG], France) C. Pinte (IPAG), F. Ménard (IPAG), E. Tatulli (IPAG), J.-P. Berger (ESO, Santiago, Chile), F. Malbet (IPAG), B. Merín (Herschel Science Centre, Madrid, Spain), E. F. van Dishoeck (Leiden University, Holland), S. Lacour (Observatoire de Paris, France), K. M. Pontoppidan (California Institute of Technology, USA), J.-L. Monin (IPAG), J. M. Brown (Max-Planck-Institut für extraterrestrische Physik

  20. MONA, LISA and VINCI Soon Ready to Travel to Paranal

    Science.gov (United States)

    2000-11-01

    Spatiale (DESPA) of the Paris Observatory. It was used in 1991 at the Kitt Peak National Observatory (Arizona, USA), for the first (coherent) combination of the light beams from two independent telescopes by means of optical fibers of fluoride glass. It has since been in operation for five years as a focal instrument at the IOTA Interferometer (Mount Hopkins, Arizona, USA) within a collaboration with the Harvard Smithsonian Center for Astrophysics), producing a rich harvest of scientific data. The VINCI partners The VINCI instrument is constructed in a collaboration between ESO (that also finances it) and the following laboratories and institutes: * DESPA (Paris Observatory) provides the expertise, the general concept, the development and integration of the optomechanics (with the exception of the camera) and the electronics, * Observatoire Midi-Pyrénées that produces the control software * The LISA infrared camera is developed by the Max-Planck-Institut für Extraterrestrische Physik (Garching, Germany), and * ESO provides the IR camera electronics and the overall observational software and is also responsible for the final integration. DESPA delivered VINCI to ESO in Garching on September 27, 2000, and is now assembling the instrument in the ESO optical workshop. It will stay here during three months, until it has been fully integrated and thoroughly tested. It will then be shipped to Paranal at the beginning of next year. After set-up and further tests, the first observations on the sky are expected in late March 2001. Fluoride fibers guide the light The heart of VINCI - named MONA - is a fiber optics beam combine unit. It is the outcome of a fertile, 10-year research partnership between Science (DESPA) and Industry ("Le Verre Fluoré" [2]). Optical fibers will be used to combine the light from two telescopes inside VINCI . Since the instrument will be working in the near-infrared region of the spectrum (wavelength 2-2.5 µm), it is necessary to use optical fibers

  1. Unexplained Brightening of Unusual Star

    Science.gov (United States)

    1997-01-01

    particular, with just two exceptions, its orbital period is longer than those of all 150 such systems known. Yet another possibility would be the nova phenomenon which is due to a sudden nuclear explosion in the atmosphere of the white dwarf. But in such cases, the brightness increase is much larger than observed here. Future investigations Consequently, it is at this moment not yet possible to understand the nature of the observed brightening of the AKO 9 binary system. Although it is one of the best observed close binary systems within any globular cluster, the available observations will have to be complemented during future investigations before the responsible mechanism may be identified. More information about this research project A provisional report about this work will be presented on January 15, 1997, at the semi-annual meeting of the American Astronomical Association in Toronto, Canada. Notes: [1] The group consists of Georges Meylan (ESO, Garching, Germany), Dante Minniti (Lawrence Livermore National Laboratory, Livermore, USA), Carlton Pryor (Rutgers Univ., Piscataway, USA), E. Sterl Phinney (Caltech, Pasadena, USA), Bruce Sams (Max-Planck-Institut für Extraterrestrische Physik, Garching, Germany), Chris G. Tinney (Anglo-Australian Observatory, Epping, Australia). [2] The phenomenon of core collapse is reminiscent of the `red-giant phase' of stellar evolution when - towards the end of its life - the outer layers of a star begin to expand while its central regions contract. [3] This corresponds to 10 6 stars/pc 3 and 0.1 stars/pc 3 , respectively. How to obtain ESO Press Information ESO Press Information is made available on the World-Wide Web (URL: http://www.eso.org../). ESO Press Photos may be reproduced, if credit is given to the European Southern Observatory.

  2. 高抗冲共聚聚丙烯/茂金属聚乙烯蜡的相容性和结晶行为研究%Miscibility and Crystallization Behavior of Metallocene Polyethylene Wax Modified Polypropylene Copolymer with High Impact Resistance

    Institute of Scientific and Technical Information of China (English)

    秦江雷; 高俊刚; 李志庭

    2006-01-01

    通过示差扫描量热仪(DSC)对高抗冲共聚聚丙烯(PP copolymer)/茂金属聚乙烯蜡(MPE wax)共混体系的熔点和结晶温度进行研究,发现MPE wax在熔融和结晶过程中都没有自己的特征峰出现,证明其已经在PP copolymer结晶时完全进入了晶体结构中,而在降温过程中,MPE wax不但没有降低PP copolymer的结晶温度,反而使之在较高的温度下结晶,显示出两者良好的相容性和MPE wax的成核作用.结晶动力学数据显示MPE wax的加入对体系的结晶行为有所影响,减缓了结晶过程并降低了体系的结晶活化能,而结晶动力学参数显示MPE wax的加入使共聚聚丙烯的结晶行为与降温速率的依赖性降低,并使a值趋于1,Ozawa指数趋近于Avrami指数.MPE wax对PP copolymer的力学性能影响很小,能很好保持PP copolymer的应用性能.

  3. Pharmacological evaluation of Mallotus philippinensis (Lam. Muell.-Arg. fruit hair extract for Anti-Inflammatory, Analgesic and Hypnotic Activity

    Directory of Open Access Journals (Sweden)

    Mayank Gangwar

    2016-03-01

    Full Text Available Recently we observed wound healing activity of 50% ethanol extract of Mallotus philippinensis Muell. Arg (MP fruit hairs extract (MPE. In several intestinal infections, localized inflammation is of common occurrence and hence we evaluated the anti-inflammatory, analgesic and hypnotic activity of MPE in different rat experimental models. Anti-inflammatory activity was evaluated by carrageenan (acute and turpentine oil induced formalin (subacute induced paw oedema and while, granuloma pouch (subacute in rats. Analgesic and hypnotic activity of MPE was undertaken by tail-flick, hot and ndash;plate and acetic acid-induced writhing tests while pentobarbitone-induced hypnotic potentiation respectively in rats.\tMPE at a dose of 200 mg/kg at 3 hr after their administration showed inhibition of formalin-induced paw oedema by 41.60% (P<0.001 and carrageenan-induced paw oedema by 55.30% (P<0.001. After 7 days of treatments, MPE showed 38.0% (P<0.001 inhibition against formalin-induced paw oedema and reduced weight of turpentine-induced granuloma pouch by 29.6% (P<0.01 and volume of exudates by 26.1% (P<0.01 respectively. MPE (200 mg/kg showed dose-dependent elevation in pain threshold and peak analgesic effect at 120 min as evidenced by increased latency period in tail flick method and increased reaction time in hot-plate test while reduction in the number of acetic acid-induced writhes by 45.7% (P<0.001. The pentobarbitone-induced hypnosis model showed potentiation, as defined by increased duration of sleep in treated group rats as compared to control. Thus, the study revealed MPE is effective in reducing acute and sub-acute inflammation and showed effective and similar analgesic activity. This seemed to be safe in the treatment of pain and inflammation. [J Intercult Ethnopharmacol 2016; 5(1.000: 14-21

  4. Spectroscopic Constants for Selected Homonuclear Diatomic Molecules. Volume 2. K through Z

    Science.gov (United States)

    1976-02-16

    and M. Desirant, Bull. Cl. Sei. Acad. Roy. Belg. 2J_, 723-35 (35, 28) Absorption, Predissociation, 1. I. Agarbiceanu , C. R...V. Kondratjew and A. Lauris, Z. Physik 92, 741-6 (35. 15) Effect of Magnetic Field, I. I. Agarbiceanu , C. R, Acad. Sei. 200

  5. Correlation of Nonexponentiality with Dynamic Heterogeneity from Four-Point Dynamic Susceptibility X4(t) and Its Approximation XT(t)

    Science.gov (United States)

    2010-01-01

    Theoretische Physik, Technische Universitat Wien, Wiedner Hauptstraße 8-10, A-1040 Wien, Austria 3Dipartimento di Fisica , Università di Pisa, Largo Pontecorvo 3...models of the glass transition generally posit a growing dynamic correlation length as causing the marked increase of in vitrifying liquids 15–19

  6. Many-Body Treatment of Navier-Stokes Fluids.

    Science.gov (United States)

    1986-09-01

    Haken, Reviews of Modern Physics, 47, (1) (1975). E2. H. Haken and W. Weidlich , p. 630 in Quantum Ootics, R. J. Glauber, ed., (Academic Press, New York...1969). E3. Hermann Haken, Light, Vol. 1, (North Holland, New York, 1981). E4. H. Heken and W. Weidlich , Zeltsehrlft fur Physik, 181, 96, (1964). ES

  7. Quantum and Classical OpticsEmerging Links

    Science.gov (United States)

    2016-05-09

    N1 2 live inside a unit N-dimensional hyper - cube, since  Y0 1j . The cube’s origin ( )¼0, 0, represents zero entanglement, corresponding to...Schmidt [3] via the classic mathematical physics text : Courant R and Hilbert D Methoden Der Mathematischen Physik 2nd edn (Berlin: Springer) 134 [3

  8. Application of Rate Theory to Accelerated Durability Testing of Structural Adhesives

    Science.gov (United States)

    1980-03-01

    interest of processing economy can be identified. This information can then be fed back into the system design process and the analyses repeated to...London, F., Problemme der Modernon Physik, Sommerfeld Festchrift. 1931 Eyring, H. and Polanyi, M., " Uber Einfache Gasreaktionen", Z. Physic, Chem

  9. Chemische Analyse durch Spectralbeobachtungen

    OpenAIRE

    Kirchhoff, Gustav Robert; Bunsen, Robert Wilhelm

    2008-01-01

    1860 fanden Gustav R. Kirchhoff und Robert W. Bunsen in ihrem Heidelberger Labor heraus, dass das durch ein Prisma geleitete Licht erhitzter chemischer Elemente charakterische Linien erzeugt. Diese Linien erlauben die eindeutige Fernidentifizierung der beteiligten Stoffe. Die beiden Forscher publizierten ihre Entdeckung in den Annalen der Physik und Chemie.

  10. Matthias Falter und die frühe Halbleitertechnik in der DDR

    Science.gov (United States)

    Dittmann, Frank

    Nach einer ganzen Reihe von Vorarbeiten weltweit1 konnten im Dezember 1947 die amerikanischen Physiker Walter H. Brattain, John Bardeen und William Shockley in den Bell Laboratories den Transistoreffekt demonstrieren. Damit legten sie den Grundstein für die Mikroelektronik als Basistechnologie des Informationszeitalters.

  11. Predicting Radiation Characteristics from Antenna Physical Dimensions

    Science.gov (United States)

    1992-12-01

    Polarized Log-Periodic Dipole Array 13. Horizontal Yagi-Uda Array // - / ./ II. INTRODUCTION New American Heritage Dictionary defines antenna as ’an...Telegraphy, p. 665, Ann. Physik , Volume 28, 1909. 8. Norton, K. A., The Propagation of Radio Waves over the Surface of the Earth and in the Upper

  12. The Effective Potential Energy Surfaces of the Nonadiabatic Collision

    Science.gov (United States)

    2009-03-01

    1. E. Schrödinger, Annalen der Physik 385 (13), 437-490 (1926). 2. M. Born and K. Huang, Dynamical Theory of Crystal Lattices. (Oxford...theory. (Dover Publications Inc., 1996). 52. in The American Heritage Dictionary of the English Language, Fourth Edition (Houghton Mifflin Company

  13. Generation Higgs

    CERN Document Server

    Hein, Till

    2004-01-01

    Im Cern bei Genf steht die grösste Protonen- und Datenschleuder der Erde. Hier werden Dinge gesucht, die vielleicht nur in der Fantasie des Physiker existieren. Doch sollte die Jagd erforgreich sein, dann ist das Universum ein offenes Geheimnis (3 pages)

  14. Meccanica ondulatoria

    CERN Document Server

    Pauli, Wolfgang

    1962-01-01

    Mentre nel famoso articolo sui principi fondamentali della meccanica ondulatoria pubblicato in "Handbuch der Physik" il professor Pauli tratta la parte non relativistica soffermandosi soprattutto sulle questioni di fondo, nelle presenti lezioni egli limita all'essenziale le considerazioni sui principie e dà invece ampio sviluppo ai metodi matematici.

  15. Werner Heisenberg (1901-1976)

    OpenAIRE

    Todorov, Ivan

    2005-01-01

    A brief review of Heisenberg's life and work: participating in the youth movement in the aftermath of World War I, creating quantum mechanics, conflict with "deutsche Physik", involvement in "Hitler's Uranium Project", last illusions. Problems and dilemmas for scientists under a dictatorship - East and West.

  16. Local cohomology in field theory (with applications to the Einstein equations)

    CERN Document Server

    Torre, C G

    1997-01-01

    This is an introductory survey of the theory of $p$-form conservation laws in field theory. It is based upon a series of lectures given at the Second Mexican School on Gravitation and Mathematical Physics held in Tlaxcala, Mexico from December 1--7, 1996. Proceedings available online at http://kaluza.physik.uni-konstanz.de/2MS/ProcMain.html.

  17. Magnetic and Structural Characterization of Fe-Ga Using Kerr Microscopy and Neutron Scattering

    Science.gov (United States)

    2010-01-01

    Appl., vol. 6, no. 1, pp. 661–690, 1907. [3] W. Heisenberg, “Zur Theorie des Ferromagnetismus,” Zeitschrift für Physik A Hadrons and Nuclei, vol. 49...A Hadrons and Nuclei, vol. 90, pp. 551–558, 1934, 10.1007/BF01333142. [19] H. J. Williams, R. M. Bozorth, and W. Shockley, “Magnetic domain patterns

  18. Report of the Working Group on Aerodynamics of Aircraft Afterbody.

    Science.gov (United States)

    1986-06-01

    Evaluacion of Supersonic Base Flow Theories. Tabakoff W. NASA CR-97129, 1968 2.1.172 Calarese W. Review of Methods of Solution of Aftertody/Exhaust Nozzle...de Estudos e Programas Physik, Mathematik GmbH CLAFA Kemforschungszentrum Base de Alfragide D-7514 Eggenstein-Leopoldshafen Alfragide 2700 Amadora

  19. The Behaviour of Al Electrodes in Aqueous Solutions,

    Science.gov (United States)

    1981-08-01

    J (19 71): Corrosion 27, 483. (14) Diggle J W, Downie T C, Goulding C W (1969): Chem Rev 69, 365. (15) Dignamn M J, Ryan P J (1968): Can j Chem 46...Binary Alloys, McGraw-Hill Book Corn - pany, New York. (28) Harkness A C, Young L (1966): Can j Chem 44, 641. (29) Hartmann W (1936): Z Physik 102, 709

  20. Die Eroberung der Atmosphäre: Wetterbeeinflussung in Süddeutschland zur Zeit des Kalten Krieges

    DEFF Research Database (Denmark)

    Achermann, Dania

    2013-01-01

    on the activities at the Institut flir Physik der Atmosphäre in Southern Bavaria, where fog dissipation and hail control were prirnarily developed for civilian and local purposes. This example depicts the relationship between the research conducted there and American developments, and demonstrates how the local...

  1. A Study of Ignition Effects on Thruster Performance of a Multi-Electrode Capillary Discharge Using Visible Emission Spectroscopy Diagnostics

    Science.gov (United States)

    2009-09-01

    and ne of the plasma. While the exact reasons for the shifts and asymmetries are still debated , there has been reasonable success in modeling and...2004. [47] J. Holtsmark. Uber die verbreiterung von spertrallinien. Ann. der Physik, 58, 1919. [48] R.H. Huddlestone and S.I. Leonard. Plasma

  2. Critique of "An Analysis of the Blast Overpressure Study Data Comparing Three Exposure Criteria," by Murphy, Khan, and Shaw

    Science.gov (United States)

    2010-08-01

    to debate the details of the middle ear muscle contraction in the AHAAH model; however, doing an unwarned calculation and then analyzing it is a...Physik Des Mittelhors Und and Uber Das Horen Bei Fehlerhaften Trommelfell. Akust. Zeits. 1936, 13–23. Cited in Experiments in Hearing; Wever, E. G

  3. Proceedings of the Workshop on Millimeter and Submillimeter Atmospheric Propagation Applicable to Radar and Missile Systems, held at Redstone Arsenal, Alabama, 20-22 March 1979

    Science.gov (United States)

    1980-02-01

    4.8 5.2 indeisen, W., 1932: M4essunjen der Orbsse und - I Anzahl der Nebeltropfen zum Studium der Sep-Nov 10.6 8.8 21.5 42.7 Koagulation Inhomogenen...zur Optik triber Medien, 6, 519-526. speziell kolloidaler Metallbhungen. Annalen Tverskoi, P. N., 1965: Physics of the atmos- der Physik , 25, fourth

  4. On the Resonance Concept in Systems of Linear and Nonlinear Ordinary Differential Equations

    Science.gov (United States)

    1965-11-01

    Determinanten und Matrizen mit Anwen- dungen in Physik und Technik). Berlin: Akademie-Verlag 1949. The author wishes to express his thanks to Prof.Dr.R.Iglisch...Case in the System of Ordinary Linear Differential Equations, Part III ( Studium des Resonanzfalles bei Systemen linearer gew6hnlicher

  5. Auswirkungen der Feldenkraismethode - Bewusstheit durch Bewegung - unter besonderer Berücksichtigung psychosomatischer Aspekte

    OpenAIRE

    Busch, Wolfgang

    2010-01-01

    Die vorliegende Arbeit beschäftigt sich mit den Auswirkungen von Feldenkrais-Bewegungsübungen auf ein Klientel, dass aus freien Stücken an Feldenkraiskursen eines niedergelassenen Feldenkraislehrers teilnimmt, wobei insbesondere gesundheitliche und psychosomatische Aspekte betrachtet werden. Feldenkrais formulierte die theoretischen Grundlagen der Methodik auf einem breiten wissenschaftlichen Fundament verschiedener Fachrichtungen, wie Medizin, Neurobiologie, Psychologie, Physik, Systemtheori...

  6. Mol-Gastronomie Mayonnaise, Aioli & Co

    Science.gov (United States)

    Vilgis, Thomas

    2004-09-01

    Hätten Sie einmal Lust auf selbst gemachte Mayonnaise? Oder ein cremiges, nach Knoblauch duftendes Aioli? Mögen Sie Fisch und eine kräftige Remoulade? Kein Problem, vor allem für Physiker, denn sie wissen, was zu tun ist, schließlich gehorchen all diese Kulinarien bestimmten molekularen Prinzipien.

  7. GEO 600 spitzt die Ohren. Der deutsche Gravitationswellendetektor erreicht seine geplante Empfindlichkeit

    Science.gov (United States)

    Borgeest, Ulf

    2005-04-01

    Die Physiker und Astronomen betreiben weltweit fünf große Laserinterferometer zur Messung von Gravitationswellen, darunter GEO 600 bei Hannover. Die hochempfindlichen Detektoren sollen helfen, die energiereichsten Vorgänge im Weltall aufzuklären und fundamentale physikalische Probleme zu lösen. Zur Zeit beginnen die ersten Messungen mit einer Empfindlichkeit, die astronomische Beobachtungen erlaubt.

  8. Kathedralen für ein Phantom

    CERN Document Server

    Klein, S

    1998-01-01

    Warum sind alle Dinge schwer? In Genf suchen 2000 Physiker nach einem Teilchen, das die Antwort geben soll. In der Hoffnung, so die Geburt des Weltalls zu verstehen, bauen sie einen Superbeschleuniger - die größte Maschine, die es je gab.

  9. Impact Dynamics: Theory and Experiment

    Science.gov (United States)

    1980-10-01

    Friedricks, K.O., and Lewy, H., " Uber die Partiallen Differenzen-gleichungen der Matematischen Physik," Math. Ann. 100 1928. 38. Van Thiel, M., "Compendium of...92647 65 DISTRIBUTION LIST No. of No. of Copies Organization Copies Organization 1 New Mexico Institute of 1 US Steel Corporation Mining and

  10. Block Iterative Methods for Elliptic and Parabolic Difference Equations.

    Science.gov (United States)

    1981-09-01

    Wisconsin 53706. (3) University of California, Los Alamos National Laboratory, Los Alamos, New Mexico 87545. *Will also appear as Los Alamos Scientic...Courant, K. Friedrichs, and H. Lewy, Uber die Partiellen Differenzengleichungen der Mathematischen Physik, Math. Ann., 100 (1928), pp. 32-74 = On the

  11. Modellierungskonzepte der Synergetik und der Theorie der Selbstorganisation

    NARCIS (Netherlands)

    Ebeling, Werner; Scharnhorst, Andrea; Braun, Norman; Saam, Nicole J.

    2015-01-01

    In der heutigen Forschungslandschaft von Modellbildung und Simulation in den Sozialwissenschaften finden sich viele Modelle, deren Wurzeln in der Physik liegen. Gebiete wie Econophysics oder Sociophysics tragen diesen Bezug in ihrem Namen. Bei der Modellbildung steht in der Regel der erkenntnistheor

  12. Satellitengeodäsie und Langbasis-Interferometrie auf der Fundamentalstation Wettzell. Kolloquiumsvorträge anläßlich des 60sten Geburtstages von Prof. Manfred Schneider.

    Science.gov (United States)

    Ilk, K.-H.

    Contents: Die krumme Geodäte (H. Ruder, M. Ruder). Zur Geschichte der Fundamentalstation Wettzell (H. Seeger et al.). Newtons Philosophiae naturalis principia mathematica (M. Schramm). Von Newton zu Einstein (M. H. Soffel). Geodäsie und Physik (S. Heitz). Erdbebenvorhersage mit SEISMOLAP (J. Zschau).

  13. Northeast Artificial Intelligence Consortium (NAIC) Review of Technical Tasks. Volume 2, Part 2.

    Science.gov (United States)

    1987-07-01

    Conference on Fifth Generation Computer Systems, ed ICOT, ICOT, 1984, pp. 613-622. Gt5del, K., Uber formal unentscheidbare S’rze der Principia ... mathematica und verwandrer Systeme I, Monatshefte fbr Mathematik und Physik 38, 1931, pp. 173- 198. [English translation in: From Frege to Gtbdel, ed van

  14. Information Integration for Concurrent Engineering (IICE) IDEF3 Process Description Capture Method Report

    Science.gov (United States)

    1995-09-01

    reference manual. report logic-92-1. Logic Group, Stanford University, CA. Gödel, K. (1931). Über Formal Unentscheidbare Sätze der Principia ... Mathematica und Verwandter Systeme, I. Monatshefte Für Mathematik und Physik 38, 173-198. IDEF Users Group. (1990). IDEF: framework, draft report

  15. Prophylactic effect of Mucuna pruriens Linn (velvet bean) seed extract against experimental Naja sputatrix envenomation: gene expression studies.

    Science.gov (United States)

    Fung, Shin Yee; Sim, Si Mui; Kandiah; Jeyaseelan; Armugam, Arunmozhiarasi; Aguiyi, John Chinyere; Tan, Nget Hong

    2014-09-01

    Mucuna pruriens is widely used in traditional medicine for treatments of various diseases. In certain region of Nigeria, the seed is used as oral prophylactics for snakebite. Rats pretreated with the aqueous extract from M. pruriens seed (MPE) were protected against the lethal effects of Naja sputatrix (Javan spitting cobra) venom [Tan et al., J Ethnopharmacol, 123 (2009) 356]. The pretreatment also protected against venom-induced histopathological changes in rat heart. To contribute to the understanding of the mechanism of cardio-protective action, the present study examined the effects of MPE-pretreatment on gene expression profile of rat heart as well as effect of MPE-pretreatment on N. sputatrix venom-induced gene expression alterations in rat heart. The gene expression profiles were examined by microarray analysis and verified by real time PCR. The results showed that pretreatment with MPE caused 50 genes in the rat heart substantially up-regulated of which 19 were related to immune responses, 7 were related to energy production and metabolism. The up-regulation of genes related to energy metabolism probably plays a role in maintaining the viability of the heart. Four other genes that were up-regulated (alpha synuclein, natriuretic peptide precursor, calsequestrin and triadin) were involved in the maintenance of homeostasis of the heart or maintaining its viability, thereby contributing to the direct protective action. The results demonstrated that protective effect of MPE pretreatment against snake venom poisoning may involve a direct action on the heart.

  16. Pleural fluid cell-free DNA integrity index to identify cytologically negative malignant pleural effusions including mesotheliomas

    Directory of Open Access Journals (Sweden)

    Sriram Krishna B

    2012-09-01

    Full Text Available Abstract Background The diagnosis of malignant pleural effusions (MPE is often clinically challenging, especially if the cytology is negative for malignancy. DNA integrity index has been reported to be a marker of malignancy. The aim of this study was to evaluate the utility of pleural fluid DNA integrity index in the diagnosis of MPE. Methods We studied 75 pleural fluid and matched serum samples from consecutive subjects. Pleural fluid and serum ALU DNA repeats [115bp, 247bp and 247bp/115bp ratio (DNA integrity index] were assessed by real-time quantitative PCR. Pleural fluid and serum mesothelin levels were quantified using ELISA. Results Based on clinico-pathological evaluation, 52 subjects had MPE (including 16 mesotheliomas and 23 had benign effusions. Pleural fluid DNA integrity index was higher in MPE compared with benign effusions (1.2 vs. 0.8; p Conclusion Pleural fluid DNA integrity index is a promising diagnostic biomarker for identification of MPEs, including mesothelioma. This biomarker may be particularly useful in cases of MPE where pleural aspirate cytology is negative, and could guide the decision to undertake more invasive definitive testing. A prospective validation study is being undertaken to validate our findings and test the clinical utility of this biomarker for altering clinical practice.

  17. Interexaminer reliability of the electromagnetic radiation receiver for determining lumbar spinal joint dysfunction in subjects with low back pain

    Energy Technology Data Exchange (ETDEWEB)

    Gemmell, H.A.; Jacobson, B.H.; Edwards, S.W.; Heng, B.J.

    1990-03-01

    Twenty subjects (6 male, 14 female) with low back pain were examined by two experienced and licensed chiropractic doctors (E1 and E2). Both examiners examined the patients using a Toftness Electromagnetic Radiation Receiver (EMRR) and by manual palpation (MP) of the spinous processes. Interexaminer reliability was calculated at three sites (L3, L4, L5) for the following combinations: (a) E1,MP--E2,MP; (b) E1,EMRR--E2,EMRR; (c) E1,MP--E2,EMRR; and (d) E2,MP--E1,EMRR, and intraexaminer reliability was calculated for the following variables: (e) E1,MP--E1,EMRR; and (f) E2,MP--E2,EMRR. Results of a Kappa coefficient analysis for interexaminer reliability of the stated combinations and at the specific sites were: (a) -0.071, 0.400, 0.200; (b) -0.013, 0.100, -0.120; (c) 0.286, 0.300, 0.200; (d) -0.081, 0.000, 0.048. These results predominantly indicate a poor to fair interexaminer reliability. The results of a Kappa coefficient analysis for intraexaminer reliability of the stated combinations were: (e) 0.111, 0.400, 0.737; (f) 0.000, 0.100, 0.368. These results indicate a poor to fair reliability. It was concluded that in subjects with low back pain the EMRR may not be a reliable indicator of spinal joint dysfunction.

  18. Efficacy and safety of povidone-iodine pleurodesis in malignant pleural effusions

    Directory of Open Access Journals (Sweden)

    Hadi Kahrom

    2017-01-01

    Full Text Available Introduction: Malignant pleural effusion (MPE is determined by the detection of malignant cells in pleural fluid or pleural tissue. Neoplasm of lung, breast, ovary and lymphoma are the causes of more than 75% of MPE. Pleurodesis is a usual technique in the management of MPE to achieve a symphysis between two layers of the pleura, and various chemical agents have been used in an attempt to produce pleurodesis. With regard to complications and limitations of these sclerosing agents, efficacy and safety of povidone-iodine have been investigated in this study. Materials and Methods: Between June 2014 and June 2016, 63 consecutive patients were admitted to the Department of Thoracic Surgery because of symptomatic MPE. After insertion of a chest tube, pleurodesis with instillation of povidone-iodine was performed. Thyroid and renal function tests were checked, and success rate as well as recurrence of MPE was monitored in the next follow-up visits. Results: The complete response to this procedure was about 53.57%, and failure of treatment was 10.71% with efficacy of 82.2%. The most common complication was pain during instillation (26.9%. Changes in thyroid and renal function tests were not significant. Conclusion: Povidone-iodine is a safe and effective agent with minor side effects in pleurodesis of patients with MPEs and can be used as an accessible and low-cost alternative than other sclerosing agents.

  19. Potential effect of Olea europea leaves, Sonchus oleraceus leaves and Mangifera indica peel extracts on aromatase activity in human placental microsomes and CYP19A1 expression in MCF-7 cell line: Comparative study.

    Science.gov (United States)

    Shaban, N Z; Hegazy, W A; Abdel-Rahman, S M; Awed, O M; Khalil, S A

    2016-08-29

    Aromatase inhibitors (AIs) provide novel approaches to the adjuvant therapy for postmenopausal women with estrogen-receptor-positive (ER+) breast cancers. In this study, different plant extracts from Olea europaea leaves (OLE), Sonchus oleraceus L. (SOE) and Mangifera indica peels (MPE) were prepared to identify phytoconstituents and measure antioxidant capacities. The effects of these three extracts on aromatase activity in human placental microsomes were evaluated. Additionally, the effects of these extracts on tissue-specific promoter expression of CYP19A1 gene in cell culture model (MCF-7) were assessed using qRT-PCR. Results showed a concentration-dependent decrease in aromatase activity after treatment with OLE and MPE, whereas, SOE showed a biphasic effect. The differential effects of OLE, SOE and MPE on aromatase expression showed that OLE seems to be the most potent suppressor followed by SOE and then MPE. These findings indicate that OLE has effective inhibitory action on aromatase at both the enzymatic and expression levels, in addition to its cytotoxic effect against MCF-7 cells. Also, MPE may be has the potential to be used as a tissue-specific aromatase inhibitor (selective aromatase inhibitor) and it may be promising to develop a new therapeutic agent against ER+ breast cancer.

  20. A gene island with two possible configurations is involved in chromatic acclimation in marine Synechococcus.

    Science.gov (United States)

    Humily, Florian; Partensky, Frédéric; Six, Christophe; Farrant, Gregory K; Ratin, Morgane; Marie, Dominique; Garczarek, Laurence

    2013-01-01

    Synechococcus, the second most abundant oxygenic phototroph in the marine environment, harbors the largest pigment diversity known within a single genus of cyanobacteria, allowing it to exploit a wide range of light niches. Some strains are capable of Type IV chromatic acclimation (CA4), a process by which cells can match the phycobilin content of their phycobilisomes to the ambient light quality. Here, we performed extensive genomic comparisons to explore the diversity of this process within the marine Synechococcus radiation. A specific gene island was identified in all CA4-performing strains, containing two genes (fciA/b) coding for possible transcriptional regulators and one gene coding for a phycobilin lyase. However, two distinct configurations of this cluster were observed, depending on the lineage. CA4-A islands contain the mpeZ gene, encoding a recently characterized phycoerythrobilin lyase-isomerase, and a third, small, possible regulator called fciC. In CA4-B islands, the lyase gene encodes an uncharacterized relative of MpeZ, called MpeW. While mpeZ is expressed more in blue light than green light, this is the reverse for mpeW, although only small phenotypic differences were found among chromatic acclimaters possessing either CA4 island type. This study provides novel insights into understanding both diversity and evolution of the CA4 process.

  1. A gene island with two possible configurations is involved in chromatic acclimation in marine Synechococcus.

    Directory of Open Access Journals (Sweden)

    Florian Humily

    Full Text Available Synechococcus, the second most abundant oxygenic phototroph in the marine environment, harbors the largest pigment diversity known within a single genus of cyanobacteria, allowing it to exploit a wide range of light niches. Some strains are capable of Type IV chromatic acclimation (CA4, a process by which cells can match the phycobilin content of their phycobilisomes to the ambient light quality. Here, we performed extensive genomic comparisons to explore the diversity of this process within the marine Synechococcus radiation. A specific gene island was identified in all CA4-performing strains, containing two genes (fciA/b coding for possible transcriptional regulators and one gene coding for a phycobilin lyase. However, two distinct configurations of this cluster were observed, depending on the lineage. CA4-A islands contain the mpeZ gene, encoding a recently characterized phycoerythrobilin lyase-isomerase, and a third, small, possible regulator called fciC. In CA4-B islands, the lyase gene encodes an uncharacterized relative of MpeZ, called MpeW. While mpeZ is expressed more in blue light than green light, this is the reverse for mpeW, although only small phenotypic differences were found among chromatic acclimaters possessing either CA4 island type. This study provides novel insights into understanding both diversity and evolution of the CA4 process.

  2. The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.

    Science.gov (United States)

    Fung, S Y; Tan, N H; Liew, S H; Sim, S M; Aguiyi, J C

    2009-04-01

    Seed of Mucuna pruriens (Velvet beans) has been prescribed by traditional medicine practitioners in Nigeria as a prophylactic oral antisnake remedy. In the present studies, we investigated the protective effects of M. pruriens seed extract (MPE) against histopathological changes induced by intravenous injection of Naja sputatrix (Malayan cobra) venom in rats pretreated with the seed extract. Examination by light microscope revealed that the venom induced histopathological changes in heart and blood vessels in liver, but no effect on brain, lung, kidney and spleen. The induced changes were prevented by pretreatment of the rats with MPE. Our results suggest that MPE pretreatment protects rat heart and liver blood vessels against cobra venom-induced damages.

  3. Asymptotics of Bayesian error probability and source super-localization in three dimensions.

    Science.gov (United States)

    Prasad, S

    2014-06-30

    We present an asymptotic analysis of the minimum probability of error (MPE) in inferring the correct hypothesis in a Bayesian multi-hypothesis testing (MHT) formalism using many pixels of data that are corrupted by signal dependent shot noise, sensor read noise, and background illumination. We perform our analysis for a variety of combined noise and background statistics, including a pseudo-Gaussian distribution that can be employed to treat approximately the photon-counting statistics of signal and background as well as purely Gaussian sensor read-out noise and more general, exponentially peaked distributions. We subsequently evaluate both the exact and asymptotic MPE expressions for the problem of three-dimensional (3D) point source localization. We focus specifically on a recently proposed rotating-PSF imager and compare, using the MPE metric, its 3D localization performance with that of conventional and astigmatic imagers in the presence of background and sensor-noise fluctuations.

  4. VizieR Online Data Catalog: PACS Evolutionary Probe (PEP-DR1) catalogs (Lutz+, 2011)

    Science.gov (United States)

    Lutz, D.; Poglitsch, A.; Altieri, B.; Andreani, P.; Aussel, H.; Berta, S.; Bongiovanni, A.; Brisbin, D.; Cava, A.; Cepa, J.; Cimatti, A.; Daddi, E.; Dominguez-Sanchez, H.; Elbaz, D.; Foerster Schreiber, N. M.; Genzel, R.; Grazian, A.; Gruppioni, C.; Harwit, M.; Le Floc'h, E.; Magdis, G.; Magnelli, B.; Maiolino, R.; Nordon, R.; Perez Garcia, A. M.; Popesso, P.; Pozzi, F.; Riguccini, L.; Rodighiero, G.; Saintonge, A.; Sanchez Portal, M.; Santini, P.; Shao, L.; Sturm, E.; Tacconi, L. J.; Valtchanov, I.; Wetzstein, M.; Wieprecht, E.

    2013-11-01

    PACS catalogs built by the PEP team, with key contributions by Stefano Berta, Benjamin Magnelli, Paola Popesso, Dieter Lutz, Francesca Pozzi, Bruno Altieri, Herve Aussel, Hoseong Hwang, Emeric Le Floc'h, Georgios Magdis, Raanan Nordon, Albrecht Poglitsch, Laurie Riguccini, Amelie Saintonge, Li Shao. For more details, please refer to Lutz et al. (2011A&A...532A..90L) and to the PDF documentation associated to the release. Data and catalogs can be retrieved from the web page http://www.mpe.mpg.de/ir/Research/PEP/publicdatareleases.php See the PDF documentation associated to the PEP DR1 release, http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_global.pdf and http://www.mpe.mpg.de/resources/PEP/DR1tarballs/readmePEP_SPIRE.pdf for more details. (69 data files).

  5. El arrendamiento financiero y valuación de opciones reales

    Directory of Open Access Journals (Sweden)

    Gastón Silverio Milanesi

    2016-01-01

    Full Text Available El trabajo estudia diferentes opciones reales simples y compuestas contenidas en los contratos de leasing, bajo una metodología que combina el método de préstamo equivalente (MPE y opciones reales. Primero se presenta formalmente el MPE y el modelo binomial para valorar las opciones del contrato. Seguida- mente se analiza el valor al vencimiento de las opciones del leasing clasificadas en: a simple: de compra, de cancelar anticipadamente, de renovación y excluyente de renovación-compra, y b compuesta: a riesgo (venture ; canon atado a intensidad de uso (percentage y de pago diferido. Utilizando diferentes casos son valuadas las opciones combinando el modelo binomial y el MPE, estimando valor expandido y valor el valor de la opción sobre el valor. Finalmente se presentan las principales conclusiones.

  6. Multi-Seed Key Distribution Scheme Test

    Institute of Scientific and Technical Information of China (English)

    XIE Yumin; SHI Feng; MING Yang; Muhammad Kamran; YANG Xiaoxu

    2006-01-01

    The key problem of securing multicast is to generate, distribute and update Session Encryption Key(SEK). Polynomial expansion with multi-seed(MPE) scheme is an approach which is based on Polynomial expansion(PE) scheme and overcomes PE's shortage. Its operation is demonstrated by using multi-seed, the group member is partitioned to many subgroups. While updating the SEK, computation is needed only in one of subgroups, the other of them will use the computation history to update their SEK. The key problems to design a MPE scheme application includes to find a feasible one way function as well as to generate a Strict Prime Number(SPN). Those technologies with multi-seed and computation history concepts make MPE as a good choice in practical applications. A prototype test system is designed and solutions of all above mentioned problems are included in this proposed paper.

  7. Research on Performance of Asphalt Modified by Polyethylene Made from Recycled Plastics%废旧塑料合成MPE颗粒对沥青改性效果的试验研究

    Institute of Scientific and Technical Information of China (English)

    王家主

    2011-01-01

    Granular modified polyethylene made from recycled plastics and tackifier can be added to asphalt mix plant to modify asphalt, which avoids the process of modifying asphalt in the factory. Two virgin asphalts, with their four components content tested, are chosen to study the MPE modified asphalt. Asphalts with different quantities of MPE are prepared by high speed shearing machine. And asphalt performance of every sample is tested, which varied with different MPE content, meanwhile, curves of performance versus MPE content are drawn. Last, all the test results and analysis indicate that MPE can obviously improve asphalt performances such as high temperature performance, aging resistance and anti-stripping. However, there is an optimal MPE content which is 6% of asphalt mass.%采用废旧塑料和增黏剂合成的MPE颗粒,可在道路沥青混合料拌和时直接投入,起到对道路沥青改性的作用,省去了在加工厂制备生产改性沥青的过程.为研究MPE对沥青的改性作用,选取两种基质沥青,测定其四组分含量,通过高速剪切设备制备不同MPE掺量的改性沥青,分别对其进行沥青性能的检测,绘制各项沥青性能随MPE掺量的变化曲线.试验结果表明,MPE对沥青的高温、老化和水稳定性能具有明显的改善作用,同时MPE存在一个最佳掺量,约为沥青质量的6%.

  8. Review Article: The Role of Molecular Pathological Epidemiology in the Study of Neoplastic and Non-neoplastic Diseases in the Era of Precision Medicine.

    Science.gov (United States)

    Ogino, Shuji; Nishihara, Reiko; VanderWeele, Tyler J; Wang, Molin; Nishi, Akihiro; Lochhead, Paul; Qian, Zhi Rong; Zhang, Xuehong; Wu, Kana; Nan, Hongmei; Yoshida, Kazuki; Milner, Danny A; Chan, Andrew T; Field, Alison E; Camargo, Carlos A; Williams, Michelle A; Giovannucci, Edward L

    2016-07-01

    Molecular pathology diagnostics to subclassify diseases based on pathogenesis are increasingly common in clinical translational medicine. Molecular pathological epidemiology (MPE) is an integrative transdisciplinary science based on the unique disease principle and the disease continuum theory. While it has been most commonly applied to research on breast, lung, and colorectal cancers, MPE can investigate etiologic heterogeneity in non-neoplastic diseases, such as cardiovascular diseases, obesity, diabetes mellitus, drug toxicity, and immunity-related and infectious diseases. This science can enhance causal inference by linking putative etiologic factors to specific molecular biomarkers as outcomes. Technological advances increasingly enable analyses of various -omics, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, metagenomics, microbiome, immunomics, interactomics, etc. Challenges in MPE include sample size limitations (depending on availability of biospecimens or biomedical/radiological imaging), need for rigorous validation of molecular assays and study findings, and paucities of interdisciplinary experts, education programs, international forums, and standardized guidelines. To address these challenges, there are ongoing efforts such as multidisciplinary consortium pooling projects, the International Molecular Pathological Epidemiology Meeting Series, and the Strengthening the Reporting of Observational Studies in Epidemiology-MPE guideline project. Efforts should be made to build biorepository and biobank networks, and worldwide population-based MPE databases. These activities match with the purposes of the Big Data to Knowledge (BD2K), Genetic Associations and Mechanisms in Oncology (GAME-ON), and Precision Medicine Initiatives of the United States National Institute of Health. Given advances in biotechnology, bioinformatics, and computational/systems biology, there are wide open opportunities in MPE to contribute to public

  9. Protective effect of Mimosa pudica L. in an L-arginine model of acute necrotising pancreatitis in rats.

    Science.gov (United States)

    Kaur, Jagdeep; Sidhu, Shabir; Chopra, Kanwaljit; Khan, M U

    2016-07-01

    Mimosa pudica is used in traditional medicine for treating various disorders such as inflammatory conditions, diarrhoea, insomnia, alopecia, urogenital infections and wounds. The present study investigated the effect of M. pudica extract (MPE) on L-arginine-induced acute necrotising pancreatitis in rats. The ethanolic extract of M. pudica leaves was studied for the presence of quercetin and gallic acid using high-performance liquid chromatography. Four groups were employed-normal control rats, L-arginine control rats (two intraperitoneal [i.p.] injections of 2 g/kg at an interval of 1 h), MPE-treated rats (400 mg/kg orally) and melatonin-treated rats (positive control 10 mg/kg i.p.), which were further divided into subgroups according to time points (24 h, 3 days and 14 days). Serum amylase, lipase, tumour necrosis factor-α (TNF-α), pancreatic amylase, nucleic acid content, protein, transforming growth factor-β1 (TGF-β1), thiobarbituric reactive substances, glutathione, nitrite/nitrate, collagen content and histopathological examination were carried out. MPE significantly improved acute necrotising pancreatitis by modulating diagnostic markers of pancreatitis such as serum lipase and pancreatic amylase, inflammation (TNF-α), and oxidative and nitrosative stress. Moreover, MPE administration induced regenerative changes in the pancreas evidenced by increased levels of pancreatic proteins, nucleic acid content and histopathology report. In addition, MPE improved TGF-β1 and collagen levels thereby preventing fibrosis. The current investigation indicates the novel role of MPE in reducing the severity of acute necrotising pancreatitis by plausible mechanisms such as anti-inflammatory and anti-fibrotic activity and by promoting repair and regeneration of the pancreas.

  10. Planlovsændringer

    DEFF Research Database (Denmark)

    Møller, Jørgen

    2002-01-01

    Planloven er ændret og kommunerne får nu ansvaret for landzoneadministrationen og for placeringen af gylletankene i det åbne land. Samtidig løser den ændrede planlov ikke det kæmpe problem, som de dansk landdistrikter lider under med de overflødige landbrugsbygninger.......Planloven er ændret og kommunerne får nu ansvaret for landzoneadministrationen og for placeringen af gylletankene i det åbne land. Samtidig løser den ændrede planlov ikke det kæmpe problem, som de dansk landdistrikter lider under med de overflødige landbrugsbygninger....

  11. Sne eller krig?

    DEFF Research Database (Denmark)

    Elling, Rasmus Christian

    2007-01-01

    Der er mange gode grunde til, at det tyrkiske militær rasler med sablen over for Irak og ikke alt handler om at nedkæmpe PKK. Men vil Tyrkiet risikere at starte sin egen Irak-krig i et af verdens mest utilgængelige steder? Udgivelsesdato: 8/11......Der er mange gode grunde til, at det tyrkiske militær rasler med sablen over for Irak og ikke alt handler om at nedkæmpe PKK. Men vil Tyrkiet risikere at starte sin egen Irak-krig i et af verdens mest utilgængelige steder? Udgivelsesdato: 8/11...

  12. Valuación de opciones simples y complejas contenidas en arrendamientos financieros

    OpenAIRE

    2016-01-01

    El valor de los contratos de arrendamiento es una función del valor presente de los cánones más las opciones reales operativas. Sin embargo, el método del préstamo equivalente (MPE), con amplia aplicación en la valuación de arrendamientos, falla porque no incorpora las opciones contenidas en el contrato. De esta forma, el presente trabajo propone un modelo de valuación combinando el MPE y el enfoque binomial para valuar opciones reales. Para lograr lo anterior, se realiza el planteamiento mat...

  13. Bearing Fault Diagnosis Based on Multiscale Permutation Entropy and Support Vector Machine

    Directory of Open Access Journals (Sweden)

    Jian-Jiun Ding

    2012-07-01

    Full Text Available Bearing fault diagnosis has attracted significant attention over the past few decades. It consists of two major parts: vibration signal feature extraction and condition classification for the extracted features. In this paper, multiscale permutation entropy (MPE was introduced for feature extraction from faulty bearing vibration signals. After extracting feature vectors by MPE, the support vector machine (SVM was applied to automate the fault diagnosis procedure. Simulation results demonstrated that the proposed method is a very powerful algorithm for bearing fault diagnosis and has much better performance than the methods based on single scale permutation entropy (PE and multiscale entropy (MSE.

  14. Kinas nye mand vil korruptionen til livs

    DEFF Research Database (Denmark)

    Høyrup Christensen, Nis

    2013-01-01

    Kampen mod korruption er det første konkrete programpunkt, som Kinas nye mand i spidsen, Xi Jinping, har meldt ud. Dermed sender han et klart signal til de 80 millioner medlemmer i partiet og til den kæmpe administration, han er øverste chef for: Der skal handling til.......Kampen mod korruption er det første konkrete programpunkt, som Kinas nye mand i spidsen, Xi Jinping, har meldt ud. Dermed sender han et klart signal til de 80 millioner medlemmer i partiet og til den kæmpe administration, han er øverste chef for: Der skal handling til....

  15. COMPARISON OF PREBIOTIC ACTIVITY OF CHITOSAN AND LACTOSE DERIVATIVES Сравнение пребиотической активности производных хитозана и лактозы

    Directory of Open Access Journals (Sweden)

    Buchakhchyan Z. V.

    2011-11-01

    Full Text Available This research is aimed to evaluate the prebiotic potential of lactitol and chitosan succinate using the vitro fermentation model. Four substrates (raftilos, lactitol, cellulose, chitosan succinate were tested in vitro, using Batch culture fermentation method with fermentation of mixed human faecal microflora . Measurement of prebiotic effect (MPE values were generated comparing bacterial changes through determination of maximum growth rates of groups, rate of substrate assimilation and production of lactate and short chain fatty acids. The present study applied the MPE theory to evaluate the in vitro prebiotic potential of substrates as novel prebiotics

  16. El arrendamiento financiero y valuación de opciones reales

    OpenAIRE

    Gastón Silverio Milanesi

    2016-01-01

    El trabajo estudia diferentes opciones reales simples y compuestas contenidas en los contratos de leasing, bajo una metodología que combina el método de préstamo equivalente (MPE) y opciones reales. Primero se presenta formalmente el MPE y el modelo binomial para valorar las opciones del contrato. Seguida- mente se analiza el valor al vencimiento de las opciones del leasing clasificadas en: a) simple: de compra, de cancelar anticipadamente, de renovación y excluyente de renovación-compra, y b...

  17. CLINICAL ANALYSIS AND TREATMENT OF 14 CASES OF EXTRAMAMMARY PAGET S DISEASE

    Institute of Scientific and Technical Information of China (English)

    傅敏刚

    2000-01-01

    ffesum6 Objectif POur diffdrencier la Maladie de Paget extra-mammaire (MPE) des autres maladies chroniques de lacpu. ANthaeS Faire l' analySe clinique et l' etude des traitements chirurgicaux d' excision dans 14 oas de MPE da taut de1987 jusu' d 1997. theultats ~tim non de la ma ladle: 12 oas sur 14, an penis et aux hourses, 1 oas an canal ingUinal et1 oas d la region twianale. Par ies emmens biochimiques, tons etaient ~t ifs pour cytokeratine et thetifs POur Protdine S-100.Pendant ie suivi gut-opratoire, o...

  18. Extrasolar Giant Planet in Earth-like Orbit

    Science.gov (United States)

    1999-07-01

    Discovery from a Long-term Project at La Silla A new extrasolar planet has been found at the ESO La Silla Observatory as a companion to iota Horologii (iota Hor) . This 5.4-mag solar-type star is located at a distance of 56 light-years and is just visible to the unaided eye in the southern constellation Horologium (The Pendulum Clock). The discovery is the result of a long-term survey of forty solar-type stars that was begun in November 1992. It is based on highly accurate measurements of stellar radial velocities, i.e. the speed with which a star moves along the line of sight. The presence of a planet in orbit around a star is inferred from observed, regular changes of this velocity, as the host star and its planet revolve around a common center of gravity. Since in all cases the star is much heavier than the planet, the resulting velocity variations of the star are always quite small. The team that found the new planet, now designated iota Hor b , consists of Martin Kürster , Michael Endl and Sebastian Els (ESO-Chile), Artie P. Hatzes and William D. Cochran (University of Texas, Austin, USA), and Stefan Döbereiner and Konrad Dennerl (Max-Planck-Institut für extraterrestrische Physik, Garching, Germany). Iodine cell provides very accurate velocity measurements iota Hor b represents the first discovery of an extrasolar planet with an ESO instrument [1]. The finding is based on data obtained with ESO's highest-resolution spectrograph, the Coudé Echelle Spectrometer (CES) at the 1.4-m Coudé Auxiliary Telescope (CAT). While this telescope has recently been decommissioned, the CES instrument is now coupled via an optical fiber link to the larger ESO 3.6-m telescope, thus permitting the continuation of this survey. The high precision radial velocity measurements that are necessary for a study of this type were achieved by means of a special calibration technique. It incorporates an iodine gas absorption cell and sophisticated data modelling. The cell is used like

  19. Elementare Teilchen von den Atomen über das Standard-Modell bis zum Higgs-Boson

    CERN Document Server

    Bleck-Neuhaus, Jörn

    2013-01-01

    Der aktuelle Wissensstand der Kern- und Elementarteilchenphysik hat eine wechselvolle Entstehungsgeschichte, oft gekennzeichnet durch schockierend neue Begriffsbildungen, die sich bis heute auch den Physik-Studierenden nur unter Mühen erschließen. Dieses Buch nutzt die kontroversen und zugleich lehrreichen Entwicklungsprozesse selber für den Zugang zu den schwierigen neuen Konzepten. Es macht verständlich, wie das physikalische Bild von den kleinsten Teilchen heute aussieht und warum es so und nicht anders entstanden ist: vom Nachweis der Existenz der Atome bis zum derzeitigen Standard-Modell der Elementarteilchenphysik, in einem ständigen Wechselspiel zwischen etablierten theoretischen Modellen, bestätigenden oder widersprechenden experimentellen Befunden, zuweilen umstrittenen neuen Begriffsbildungen, verbesserten Experimenten usw. - ein Prozess, der sicher auch künftig weiter geht. Leitschnur der Darstellung ist eine auch im Detail möglichst nachvollziehbare Argumentation. Physik-Studierende vor...

  20. Repeatability and accuracy of the new Scheimpflug-Placido topographer for measuring corneal refractive power in myopic eyes%新型Scheimpflug眼前节全景仪评估近视患者角膜屈光力的重复性和准确性

    Institute of Scientific and Technical Information of China (English)

    潘超; 黄锦海; 华焱军; 谭维娜; 鲁伟聪; 王勤美

    2014-01-01

    目的 采用Sirius眼前节全景仪2种方法获得近视患者角膜屈光力,评估其重复性与准确性.方法 前瞻性研究.52例(52眼)接受LASIK术前检查的近视患者,平均年龄为(21.6±4.8)岁,平均等效球镜度为(-4.8±2.1)D;分别应用Keratron角膜地形图仪和Sirius眼前节全景仪测量角膜屈光力,每只眼连续测量3次.Keratron提供角膜模拟屈光力Km,Sirius提供2种角膜屈光力:角膜模拟屈光力Sim K和不同入瞳直径下光路追迹法获得的入瞳角膜屈光力(MPE).变异系数、Cronbach's Alpha系数及组内相关系数评估Sirius获得的角膜屈光力的重复性;采用重复测量方差分析比较Sirius获得的Sim K、MPE与Keratron获得的Km之间的差异;采用Pearson相关分析Sim K、MPE和Km之间的相关性,Bland-Altman图评估Sim K、MPE和Km之间的一致性.结果 Sim K、MPE3、MPE4、MPE4.5、MPE5、MPE6、MPE7、Km分别为(42.91±1.52)D、(42.25±1.50)D、(42.42±1.52)D、(42.52±1.52)D、(42.63±1.55)D、(42.87±1.57)D、(43.11±1.60)D、(42.99±1.50)D.Sirius测量的所有参数变异系数均小于1%,Cronbach's Alpha系数和组内相关系数均大于0.99.Sim K比Km平均小0.08 D,差异有统计学意义(t=4.11,P<0.01).MPE3比Km平均小0.74 D,差异有统计学意义(t=32.00,P<0.01).Pearson相关分析显示Sim K、MPE与Km均有密切的相关性(r均>0.98,P<0.01).Bland-Altman图显示Sim K与Km、MPE3与Km的95%一致性区间分别为(-0.35 D,0.19 D)、(-1.07 D,-0.41 D).结论 Sirius 2种方法获得的近视患者角膜屈光力具有很好的重复性.Sim K和Km具有很好的一致性,可以替代使用.光路追迹法获得的角膜屈光力明显低于Km,不能直接代入IOL计算公式.%Objective To assess the repeatability and accuracy of two instruments for measuring corneal refractive power in myopic eyes:the Scheimpflug-Placido topographer (Sirius) and the Keratron topographer.Methods Fifty-two eyes of 52 pre-LASIK myopic volunteers whose

  1. Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study.

    Science.gov (United States)

    Gangwar, Mayank; Gautam, Manish Kumar; Sharma, Amit Kumar; Tripathi, Yamini B; Goel, R K; Nath, Gopal

    2014-01-01

    Mallotus philippinensis is an important source of molecules with strong antioxidant activity widely used medicinal plant. Previous studies have highlighted their anticestodal, antibacterial, wound healing activities, and so forth. So, present investigation was designed to evaluate the total antioxidant activity and radical scavenging effect of 50% ethanol fruit glandular hair extract (MPE) and its role on Human Erythrocytes. MPE was tested for phytochemical test followed by its HPLC analysis. Standard antioxidant assays like DPPH, ABTS, hydroxyl, superoxide radical, nitric oxide, and lipid peroxidation assay were determined along with total phenolic and flavonoids content. Results showed that MPE contains the presence of various phytochemicals, with high total phenolic and flavonoid content. HPLC analysis showed the presence of rottlerin, a polyphenolic compound in a very rich quantity. MPE exhibits significant strong scavenging activity on DPPH and ABTS assay. Reducing power showed dose dependent increase in concentration absorption compared to standard, Quercetin. Superoxide, hydroxyl radical, lipid peroxidation, nitric oxide assay showed a comparable scavenging activity compared to its standard. Our finding further provides evidence that Mallotus fruit extract is a potential natural source of antioxidants which have a protective role on human Erythrocytes exhibiting minimum hemolytic activity and this justified its uses in folklore medicines.

  2. Antioxidant Capacity and Radical Scavenging Effect of Polyphenol Rich Mallotus philippenensis Fruit Extract on Human Erythrocytes: An In Vitro Study

    Directory of Open Access Journals (Sweden)

    Mayank Gangwar

    2014-01-01

    Full Text Available Mallotus philippinensis is an important source of molecules with strong antioxidant activity widely used medicinal plant. Previous studies have highlighted their anticestodal, antibacterial, wound healing activities, and so forth. So, present investigation was designed to evaluate the total antioxidant activity and radical scavenging effect of 50% ethanol fruit glandular hair extract (MPE and its role on Human Erythrocytes. MPE was tested for phytochemical test followed by its HPLC analysis. Standard antioxidant assays like DPPH, ABTS, hydroxyl, superoxide radical, nitric oxide, and lipid peroxidation assay were determined along with total phenolic and flavonoids content. Results showed that MPE contains the presence of various phytochemicals, with high total phenolic and flavonoid content. HPLC analysis showed the presence of rottlerin, a polyphenolic compound in a very rich quantity. MPE exhibits significant strong scavenging activity on DPPH and ABTS assay. Reducing power showed dose dependent increase in concentration absorption compared to standard, Quercetin. Superoxide, hydroxyl radical, lipid peroxidation, nitric oxide assay showed a comparable scavenging activity compared to its standard. Our finding further provides evidence that Mallotus fruit extract is a potential natural source of antioxidants which have a protective role on human Erythrocytes exhibiting minimum hemolytic activity and this justified its uses in folklore medicines.

  3. Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain

    DEFF Research Database (Denmark)

    Papathanasiou, Theodoros; Juul, Rasmus Vestergaard; Heegaard, Anne-Marie

    2016-01-01

    plantar incision model using an electronic von Frey device. The percentage of maximum possible effect (%MPE) and the area under the response curve (AUC) were used for evaluation of the antihyperalgesic effects of the drugs. Identification of synergistic interactions was based on Loewe additivity response...

  4. Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice.

    Science.gov (United States)

    Prasad, Sahdeo; Kalra, Neetu; Singh, Madhulika; Shukla, Yogeshwer

    2008-03-01

    To investigate antioxidant potential of lupeol/mango pulp extract (MPE) in testosterone induced oxidative stress in prostate of male Swiss albino mice. Oral treatment of lupeol (1 mg/animal) and MPE (1 mL [20% w/v]/animal) was given separately to animals along with subcutaneous injection of testosterone (5 mg/kg body weight) consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species (ROS) levels, lipid peroxidation and antioxidant enzymes status (catalase, superoxide dismutase, glutathione reductase, glutathione-S-transferase). In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes. The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. Mango and its constituents, therefore, deserve study as a potential chemopreventive agent against prostate cancer.

  5. Enhanced Blood Compatibility of Metallocene Polyethylene Subjected to Hydrochloric Acid Treatment for Cardiovascular Implants

    Directory of Open Access Journals (Sweden)

    Saravana Kumar Jaganathan

    2014-01-01

    Full Text Available Blood compatibility of metallocene polyethylene (mPE was investigated after modifying the surface using hydrochloric acid. Contact angle of the mPE exposed to HCl poses a decrease in its value which indicates increasing wettability and better blood compatibility. Surface of mPE analyzed by using FTIR revealed no significant changes in its functional groups after treatment. Furthermore, scanning electron microscope images supported the increasing wettability through the modifications like pit formations and etching on the acid rendered surface. To evaluate the effect of acid treatment on the coagulation cascade, prothrombin time (PT and activated partial thromboplastin time (APTT were measured. Both PT and APTT were delayed significantly (P<0.05 after 60 min exposure implying improved blood compatibility of the surfaces. Hemolysis assay of the treated surface showed a remarkable decrease in the percentage of lysis of red blood cells when compared with untreated surface. Moreover, platelet adhesion assay demonstrated that HCl exposed surfaces deter the attachment of platelets and thereby reduce the chances of activation of blood coagulation cascade. These results confirmed the enhanced blood compatibility of mPE after HCl exposure which can be utilized for cardiovascular implants like artificial vascular prostheses, implants, and various blood contacting devices.

  6. Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice

    Institute of Scientific and Technical Information of China (English)

    Sahdeo Prasad; Neetu Kalra; Madhulika Singh; Yogeshwer Shukla

    2008-01-01

    Aim: To investigate antioxidant potential of lupeol/mango pulp extract (MPE) in testosterone induced oxidative stress in prostate of male Swiss albino mice. Methods: Oral treatment of lupeol (1 mg/animal) and MPE (1 mL [20% w/v]/animal) was given separately to animals along with subcutaneous injection of testosterone (5 mg/kg body weight)consecutively for 15 days. At the end of the study period, the prostate was dissected out for the determination of reactive oxygen species (ROS) levels, lipid peroxidation and antioxidant enzymes status (catalase, superoxide dismutase,glutathione reductase, glutathione-S-transferase). Results: In testosterone treated animals, increased ROS resulted in depletion of antioxidant enzymes and increase in lipid peroxidation in mouse prostate. However, lupeol/MPE treatment resulted in a decrease in ROS levels with restoration in the levels of lipid peroxidation and antioxidant enzymes. Conclusion: The results of the present study demonstrate that lupeol/MPE are effective in combating oxidative stress-induced cellular injury of mouse prostate. Mango and its constituents, therefore, deserve study as a potential chemopreventive agent against prostate cancer.

  7. Meta Analysis of Lentinan Injection plus Cisplatin in Treatment of Malignant Pleural Effusion

    Institute of Scientific and Technical Information of China (English)

    WANG Quan; HE Xi-ran; WANG Man-cai; TIAN Jin-hui

    2011-01-01

    Objective To evaluate the efficacy and safety of lentinan injection plus cisplatin (LIC) in the treatment of malignant pleural effusion (MPE).Methods We searched the database of Cochrane Library,PubMed,EMBASE,ISI Web of Knowledge,Chinese Biomedical Literature Database,Chinese Scientific Journals Full-text Database,Chinese Journal Full-text,and Google Scholar,etc.,up to February 28th,2011 to identify randomized controlled trials (RCTs) about lentinan injection (LI) for MPE,evaluate the quality of the included studies,and analyze the data by Cochrane Collaboration's RevMan5.0 software.Results Twenty-nine RCTs involving 1831 patients were included.Meta analysis results suggested that there were some differences when comparing LIC with control groups suffering from MPE,for LIC could improve the near-term curative effect and the quality of life to some extent.Besides,compared with chemotherapy alone,LI plus chemotherapy had an advantage in relieving adverse reactions,such as gastrointestinal reactions,myelosuppression,chest pain,and general malaise.Conclusion The current evidence indicates that LI may have adjuvant therapeutic effects for MPE.

  8. Improvement Comparison of Different Lattice-based Discriminative Training Methods in Chinese-monolingual and Chinese-English-bilingual Speech Recognition%各种不同的基于词格的鉴别性训练方法在中文单语以及中英双语语音识别系统中的性能改善调研及比较

    Institute of Scientific and Technical Information of China (English)

    QIAN Yan-Min; SHAN Yu-Xiang; WANG Lin-Fang; LIU Jia

    2012-01-01

    Discriminative training approaches such as minimum phone error (MPE),feature minimum phone error (fMPE) and boosted maximum mutual information (BMMI) have brought remarkable improvement to the speech community in recent years,however,much work still remains to be done.This paper investigates the performances of three lattice-based discriminative training methods in detail,and does a comparison of different I-smoothing methods to obtain more robust models in the Chinese-monolingual situation.The complementary properties of the different discriminative training methods are explored to perform a system combination by recognizer output voting error reduction (ROVER).Although discriminative training is normally used in monolingual systems,this paper systematically investigates its use for bilingual speech recognition,including MPE,fMPE,and BMMI.A new method is proposed to generate significantly better lattices for training the bilingual model,and complementary discriminative training models are also explored to get the best ROVER performance in the bilingual situation.Experimental results show that all forms of discriminative training can reduce the word error rate in both monolingual and bilingual systems,and that combining complementary discriminative training methods can improve the performance significantly.

  9. Two micron laser development for atmospheric remote sensing at NASA Langley Research Center

    Science.gov (United States)

    Brockman, Philip

    1992-01-01

    The topics addressed are: (1) eye safety revision of infrared MPE; (2) Tm:Ho dynamics characterization, which includes spectroscopy, laser experiments, and modeling; and (3) Q.M. model calculation, which includes energy levels, electric and magnetic dipole transition probabilities, lifetimes, branching ratios, absorption spectra, and emission spectra; (3) Q.M. model calculation; and (4) heat propagation in a laser rod.

  10. NCBI nr-aa BLAST: CBRC-MLUC-01-1158 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MLUC-01-1158 ref|YP_001019930.1| hypothetical protein Mpe_A0733 [Methylibium petrol...eiphilum PM1] gb|ABM93695.1| conserved hypothetical protein [Methylibium petroleiphilum PM1] YP_001019930.1 2.4 29% ...

  11. NCBI nr-aa BLAST: CBRC-OPRI-01-0197 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OPRI-01-0197 ref|YP_001022701.1| hypothetical protein Mpe_A3513 [Methylibium petrol...eiphilum PM1] gb|ABM96466.1| conserved hypothetical protein [Methylibium petroleiphilum PM1] YP_001022701.1 2.6 23% ...

  12. NCBI nr-aa BLAST: CBRC-ACAR-01-0608 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-0608 ref|YP_001019879.1| hypothetical protein Mpe_A0682 [Methylibium petrol...eiphilum PM1] gb|ABM93644.1| conserved hypothetical protein [Methylibium petroleiphilum PM1] YP_001019879.1 1.2 34% ...

  13. NCBI nr-aa BLAST: CBRC-LAFR-01-2059 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-2059 ref|YP_001019879.1| hypothetical protein Mpe_A0682 [Methylibium petrol...eiphilum PM1] gb|ABM93644.1| conserved hypothetical protein [Methylibium petroleiphilum PM1] YP_001019879.1 2.1 30% ...

  14. NCBI nr-aa BLAST: CBRC-XTRO-01-0559 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-0559 ref|YP_001022990.1| hypothetical protein Mpe_A3802 [Methylibium petrol...eiphilum PM1] gb|ABM96755.1| conserved hypothetical transmembrane protein [Methylibium petroleiphilum PM1] YP_001022990.1 3e-92 66% ...

  15. Multiscale permutation entropy analysis of electrocardiogram

    Science.gov (United States)

    Liu, Tiebing; Yao, Wenpo; Wu, Min; Shi, Zhaorong; Wang, Jun; Ning, Xinbao

    2017-04-01

    To make a comprehensive nonlinear analysis to ECG, multiscale permutation entropy (MPE) was applied to ECG characteristics extraction to make a comprehensive nonlinear analysis of ECG. Three kinds of ECG from PhysioNet database, congestive heart failure (CHF) patients, healthy young and elderly subjects, are applied in this paper. We set embedding dimension to 4 and adjust scale factor from 2 to 100 with a step size of 2, and compare MPE with multiscale entropy (MSE). As increase of scale factor, MPE complexity of the three ECG signals are showing first-decrease and last-increase trends. When scale factor is between 10 and 32, complexities of the three ECG had biggest difference, entropy of the elderly is 0.146 less than the CHF patients and 0.025 larger than the healthy young in average, in line with normal physiological characteristics. Test results showed that MPE can effectively apply in ECG nonlinear analysis, and can effectively distinguish different ECG signals.

  16. Integration of molecular pathology, epidemiology and social science for global precision medicine.

    Science.gov (United States)

    Nishi, Akihiro; Milner, Danny A; Giovannucci, Edward L; Nishihara, Reiko; Tan, Andy S; Kawachi, Ichiro; Ogino, Shuji

    2016-01-01

    The precision medicine concept and the unique disease principle imply that each patient has unique pathogenic processes resulting from heterogeneous cellular genetic and epigenetic alterations and interactions between cells (including immune cells) and exposures, including dietary, environmental, microbial and lifestyle factors. As a core method field in population health science and medicine, epidemiology is a growing scientific discipline that can analyze disease risk factors and develop statistical methodologies to maximize utilization of big data on populations and disease pathology. The evolving transdisciplinary field of molecular pathological epidemiology (MPE) can advance biomedical and health research by linking exposures to molecular pathologic signatures, enhancing causal inference and identifying potential biomarkers for clinical impact. The MPE approach can be applied to any diseases, although it has been most commonly used in neoplastic diseases (including breast, lung and colorectal cancers) because of availability of various molecular diagnostic tests. However, use of state-of-the-art genomic, epigenomic and other omic technologies and expensive drugs in modern healthcare systems increases racial, ethnic and socioeconomic disparities. To address this, we propose to integrate molecular pathology, epidemiology and social science. Social epidemiology integrates the latter two fields. The integrative social MPE model can embrace sociology, economics and precision medicine, address global health disparities and inequalities, and elucidate biological effects of social environments, behaviors and networks. We foresee advancements of molecular medicine, including molecular diagnostics, biomedical imaging and targeted therapeutics, which should benefit individuals in a global population, by means of an interdisciplinary approach of integrative MPE and social health science.

  17. 50 CFR 680.23 - Equipment and operational requirements.

    Science.gov (United States)

    2010-10-01

    ... States accessible by road or regularly scheduled air service; and (5) Provide an approved observer... operator must test each scale or scale system used to weigh CR crab one time during each 24-hour period... accurate and timely manner. (i) Belt scales. The MPE for the daily at-sea scale tests is plus or minus 3...

  18. Use of indwelling pleural catheters for the definitive treatment of malignant pleural effusion

    Directory of Open Access Journals (Sweden)

    Fernando Conrado Abrão

    Full Text Available ABSTRACT Objective: To evaluate the safety and feasibility of the use of indwelling pleural catheters (IPCs in patients with malignant pleural effusion (MPE. Methods: We prospectively collected data from patients with MPE undergoing IPC placement between January of 2014 and July of 2015. All patients submitted to IPC placement had a life expectancy > 30 days, in accordance with the MPE treatment guidelines established by the British Thoracic Society. The data collected included gender, age, body mass index, primary cancer site, duration of IPC drainage, IPC-related complications, length of hospital stay, pleural effusion recurrence, and occurrence of spontaneous pleurodesis. Results: A total of 19 patients underwent IPC placement during the study period. Median overall survival after IPC insertion was 145 days. The median follow-up among the surviving patients was 125 days (range, 53-485 days, and the median time between catheter insertion and removal was 31 days (range, 2-126 days. There were IPC-related complications in 5 patients (26.2%, and spontaneous pleurodesis was achieved in 8 (42.0%. Among those 8 patients, the IPC was removed between days 30 and 126 in 4, and spontaneous pleurodesis occurred within the first 30 days in 4. Conclusions: The use of IPCs seems to be feasible and safe in patients with MPE.

  19. Intelligent bakteriebekæmpelse

    DEFF Research Database (Denmark)

    Givskov, Michael Christian

    2004-01-01

    En lovende metode til at bekæmpe bakterielle infektioner er populært sagt at forhindre forhindre bakterierne i at kommunikere med hinanden. Ved at hæmme bakteriernes kommunikationssystemer, kan man reducere ellers sygdomsfremkaldende bakterier til harmløse....

  20. Det er ikke altid rationelt at være rationel

    DEFF Research Database (Denmark)

    Mehlsen, Camilla

    2009-01-01

    Interview med Knud Illeris: Tidens herskende uddannelsestænkning glemmer den menneskelige faktor, som ellers har været Danmarks trumf. Det er en kæmpe fejl, lyder det fra læringsforsker Knud Illeris, der nu træder tilbage som universitetsprofessor ved DPU. Udgivelsesdato: Maj-Juni...

  1. Lagrangian predictability of high-resolution regional models: the special case of the Gulf of Mexico

    Directory of Open Access Journals (Sweden)

    P. C. Chu

    2004-01-01

    Full Text Available The Lagrangian prediction skill (model ability to reproduce Lagrangian drifter trajectories of the nowcast/forecast system developed for the Gulf of Mexico at the University of Colorado at Boulder is examined through comparison with real drifter observations. Model prediction error (MPE, singular values (SVs and irreversible-skill time (IT are used as quantitative measures of the examination. Divergent (poloidal and nondivergent (toroidal components of the circulation attractor at 50m depth are analyzed and compared with the Lagrangian drifter buoy data using the empirical orthogonal function (EOF decomposition and the measures, respectively. Irregular (probably, chaotic dynamics of the circulation attractor reproduced by the nowcast/forecast system is analyzed through Lyapunov dimension, global entropies, toroidal and poloidal kinetic energies. The results allow assuming exponential growth of prediction error on the attractor. On the other hand, the q-th moment of MPE grows by the power law with exponent of 3q/4. The probability density function (PDF of MPE has a symmetrical but non-Gaussian shape for both the short and long prediction times and for spatial scales ranging from 20km to 300km. The phenomenological model of MPE based on a diffusion-like equation is developed. The PDF of IT is non-symmetric with a long tail stretched towards large ITs. The power decay of the tail was faster than 2 for long prediction times.

  2. SIMULTANEOUS SAXS/WAXS/DSC STUDIES ON MICROSTRUCTURE OF CONVENTIONAL AND METALLOCENE-BASED ETHYLENE-BUTENE COPOLYMERS

    Institute of Scientific and Technical Information of China (English)

    Jun-ting Xu; Bo-tao Li; Zhi-qiang Fan; Anthony J. Ryan

    2004-01-01

    The fractions of one metallocene-based (mPE) and one conventional (znPE) ethylene-butene copolymer eluted at 80-82℃ from temperature rising elution fractionation were selected for DSC and time-resolved small angle X-ray scattering (SAXS) and wide angle X-ray scattering (WAXS) characterization. The DSC and WAXS results show that two crystal structures exist in both mPE and znPE: structure A with higher melting temperature and structure B with lower melting temperature. It was found that original znPE (s-znPE) contains more highly ordered structure A than original mPE (s-mPE)in spite of the higher comonomer content of znPE. Another structure C is also identified because of higher crystallinity measured by WAXS than by DSC and is attributed to the interfacial region. The SAXS data were analyzed with correlation function and two maxima were observed in s-mPE and s-znPE, in agreement with the conclusion of two crystal populations drawn from DSC and WAXS results. These two crystal populations have close long periods in s-mPE, but very different long periods in s-znPE. In contrast, freshly crystallized mPE and znPE (f-mPE and f-znPE) contain only a single crystal population with a broader distribution of long period.

  3. On The Estimation of Survival Function and Parameter Exponential Life Time Distribution

    Directory of Open Access Journals (Sweden)

    Hadeel S. Al-Kutubi

    2009-01-01

    Full Text Available Problem statement: The study and research of survival or reliability or life time belong to the same area of study but they may belong to a different area of application. In survival analysis one can use several life time distribution, exponential distribution with mean life time θ is one of them. To estimate this parameter and survival function we must be used estimation procedures with less MSE and MPE. Approach: The only statistical theory that combined modeling inherent uncertainty and statistical uncertainty is Bayesian statistics. The theorem of Bayes provided a solution to how learn from data. Bayes theorem was depending on prior and posterior distribution and standard Bayes estimator depends on Jeffery prior information. In this study we annexed Jeffery prior information to get the modify Bayes estimator and then compared it with standard Bayes estimator and maximum likelihood estimator to find the best (less MSE and MPE. Results: when we derived Bayesian and Maximum likelihood of the scale parameter and survival functions. Simulation study was used to compare between estimators and Mean Square Error (MSE and Mean Percentage Error (MPE of estimators are computed. Conclusion: The new proposed estimator of modify Bayes estimator in parameter and survival function was the best estimator (less MSE and MPE when we compared it with standard Bayes and maximum likelihood estimator.

  4. Pleural Fluid Pentraxin-3 for the Differential Diagnosis of Pleural Effusions

    Science.gov (United States)

    Yeo, Chang Dong; Kim, Jin Woo; Cho, Mi Ran; Kang, Ji Young; Kim, Young Kyoon; Lee, Sang Haak; Park, Chan Kwon; Kim, Sang Ho; Park, Mi Sun; Yim, Hyeon Woo; Park, Jong Y.

    2013-01-01

    Background Conventional biomarkers cannot always establish the cause of pleural effusions; thus, alternative tests permitting rapid and accurate diagnosis are required. The primary aim of this study is to assess the ability of pentraxin-3 (PTX3) in order to diagnose the cause of pleural effusion and compare its efficacy to that of other previously identified biomarkers. Methods We studied 118 patients with pleural effusion, classified as transudates and exudates including malignant, tuberculous, and parapneumonic effusions (MPE, TPE, and PPE). The levels of PTX3, C-reactive protein (CRP), procalcitonin (PCT) and lactate in the pleural fluid were assessed. Results The levels of pleural fluid PTX3 were significantly higher in patients with PPE than in those with MPE or TPE. PTX3 yielded the most favorable discriminating ability to predict PPE from MPE or TPE by providing the following: area under the curve, 0.74 (95% confidence interval, 0.63-0.84), sensitivity, 62.07%; and specificity, 81.08% with a cut-off point of 25.00 ng/mL. Conclusion Our data suggests that PTX3 may allow improved differentiation of PPE from MPE or TPE compared to the previously identified biomarkers CRP and PCT. PMID:24416055

  5. Pleural LDH as a prognostic marker in adenocarcinoma lung with malignant pleural effusion.

    Science.gov (United States)

    Verma, Akash; Phua, Chee Kiang; Sim, Wen Yuan; Algoso, Reyes Elmer; Tee, Kuan Sen; Lew, Sennen J W; Lim, Albert Y H; Goh, Soon Keng; Tai, Dessmon Y H; Kor, Ai Ching; Ho, Benjamin; Abisheganaden, John

    2016-06-01

    To study the performance of serum and pleural lactate dehydrogenase (LDH) level in predicting survival in patients with adenocarcinoma lung presenting with malignant pleural effusions (MPE) at initial diagnosis.Retrospective cohort study of the patient hospitalized for adenocarcinoma lung with MPE in year 2012.Univariate analyses showed lower pleural fluid LDH 667 (313-967) versus 971 (214-3800), P = 0.04, female gender 9 (100%) versus 27 (41.5%), P = 0.009, never smoking status 9 (100%) versus 36 (55.3%), P = 0.009, and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) therapy 8 (89%) versus 26 (40%), P = 0.009 to correlate with survival of more than 1.7 year versus less than 1.7 year. In multivariate analysis, low pleural fluid LDH and female gender maintained significance. The pleural LDH level of ≤1500 and >1500 U/L discriminated significantly (P = 0.009) between survival.High pleural LDH (>1500 IU/L) predicts shorter survival (less than a year) in patients with adenocarcinoma lung presenting with MPE at the time of initial diagnosis. This marker may be clinically applied for selecting therapeutic modality directed at prevention of reaccumulation of MPE. Patients with low pleural LDH may be considered suitable for measures that provide more sustained effect on prevention of reaccumulation such as chemical pleurodesis or tunneled pleural catheter.

  6. International Conference on Ultrastructure Processing of Ceramics, Glasses and Composites (3rd) Held in San Diego, California on February 23-27, 1988.

    Science.gov (United States)

    1988-04-01

    scientists from the disciplines of materials science, ceramics, polymer , chemistry, physics and mechanics were able to learn from one another. The...Pk, NC 27709 Physikal Institut Universitat Wurzburg DALE, George Wurzburg, GERMANY Massachusetts Institute of Technology Room 13-4069 CARTIER , George...McGRATH, J.E. NOZOYE, M. Dept of Chemistry/ Polymers Matis National Chemical Lab and Interface Lab for Industry VPI Tsukuba, IBaraki, 305 JAPAN Blacksburgh

  7. Extreme Ultraviolet Beam-Foil Spectroscopy of Highly Ionized Neon and Argon.

    Science.gov (United States)

    1986-08-01

    velocity v, where the cross sections for electron capture scale as v- . For example, 99 Andresen and Veje calculate a maximum capture cross section into s...Andresen, S. Hultberg, B. Jelenkovic, L. Liljeby, S. Mannervik and E. Veje , Z. Physik A 242, 101 (1979). 88. B. Andresen, B. Denne, J. 0. Ekberg, L...A. Trigueiros and E. Veje , Phys. Rev. A 26, 2468 (1982). 90. H. D. Betz, D. Roschenthaler and J. Rothermel, Phys. Rev. Ltr. 50, 34 (1983). 91. A

  8. International Laser Radar Conference (16th) held at the Massachusetts Institute of Technology, Cambridge, Massachusetts on 20-24 July 1992. Part 1

    Science.gov (United States)

    1993-07-24

    Aspendale, Victoria North York Ontario AUSTRALIA M3J 1P3 CANADA Professor Giorgio Fiocco Dr. Wolfgang Renger Dipto di Fisica DLR Institut fir Physik...der Citta Universitaria Atmosphare Pizzale Aldo Moro #2 D-8031 Oberplaffenhofen 00185-Roma GERMANY ITALY Dr. Pierre H. Flamant Dr. Leopoldo Stefanutti...Adriani, Gian Paolo Gobbi and Sante Centurioni Istituto Fisica dell’Atmosfera, CNR, C.P. 27, Frascati, Italy The Pinatubo eruptions of June 1991

  9. Novel Quantum Phases at Interfaces

    Science.gov (United States)

    2014-12-12

    diversity  of   our  research  efforts,  I  will  just   flag  the  work  on  the  entanglement  spectrum  of  strongly...The University of Texas at Austin, Austin, Texas 78712, USA 2)Theoretische Physik, ETH Zürich, CH-8093 Zürich, Switzerland (Dated: 4 November 2014

  10. Physics, History, and the German Atomic Bomb.

    Science.gov (United States)

    Walker, Mark

    2017-04-27

    Physics, History, and the German Atomic Bomb. This paper examines the German concept of a nuclear weapon during National Socialism and the Second World War. Zusammenfassung: Physik, Geschichte und die deutsche Atombombe. Dieser Aufsatz untersucht die deutsche Vorstellung einer nuklearen Waffe während des Nationalsozialismus und des Zweiten Weltkrieges. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Proceedings of the Joint International Symposium on Molten Salts. Held in Honolulu Hawaii on 18-23 October 1987. Volume 87-7

    Science.gov (United States)

    1987-01-01

    Physik, Universitat Mainz. Germany +Dipartimento di Fisica and ICTP. Trieste. Italy ABSTRACT We give a short review of the progress done recently in the...eumoarNN103N27itue 300 120 2.9 +’ + /4 + 0’ , , ’ . / 2 58, 5o38 ?!58 1000 -2.0 0 Figure ~ ~ + 3: Poeta -cdt ’gamo nadNqitplt banda ie pOvaus nth ole eumoa NN 3

  12. General relativity 50 years old

    CERN Multimedia

    1966-01-01

    In May 1916, 'The Foundations of General Relativity Theory' by Albert Einstein was published in 'Annalen der Physik'. Fifty years later, this major contribution to scientific thought still has a rather isolated position with respect to the main-stream of scientific theory. (In contrast, the Special Theory of Relativity is one of the cornerstones of sub-nuclear physics.) To mark the anniversary of the publication of Einstein's paper a theoretician from CERN discusses the theory and its present status.

  13. Numerical Grid Generation. Proceedings of a Symposium on the Numerical Generation of Curvilinear Coordinate Systems and their Use in the Numerical Solution of Partial Differential Equations, held April 1982, Nashville, Tennessee

    Science.gov (United States)

    1982-04-01

    Nashville, Tenn. 31. Kober, H. (1957) " Dictionary of Conformal Representations," Dover Publica- tions, Inc., New York. 32. Nehari, Z. (1952) "Conformal...Stoker, Water Waves, Interecience Publishers, New York, 1957. 3. J.V. Wehausen & E.V. Laitone, "Surface Waves", Handbuch der Physik , Vol. 9, Springer...Hypervelocity Impact Cratering.":" AIAA Paper No. 69-354. 4. Kober, H. (1952) " Dictionary of Conformal Representations." New York: Dover Publications, Inc

  14. On Channel Sharing in Discrete-Time, Multi-Access Broadcast Communications,

    Science.gov (United States)

    1980-09-01

    be solved in terms of "known" functions, lead us to the boundaries of our small dictionary of "known" functions. Moreover, the algorithms suggested by...solutions is. most probably, unattainable, unless of course we expand our dictionary to "know" new functions. In our case, it is necessary to "know...1976. 266 . . .....--------------- •" . I - t7 .. .. (COUR 28] Courant, R., K. Friedrichs, and H. Lewy, "Differenzengleichungen der Mathematischen Physik

  15. Proceedings of the Cloud Impacts on DoD Operations and Systems 1993 Conference (CIDOS - 93) Held in Fort Belvoir, Virginia on 16-19 November 1993

    Science.gov (United States)

    1994-07-01

    Physics (Beitrdge zur Physik der Atmosphdre), 54(1), 57-71 8 Kilmer, N H., and H. Rachele, 1993 Easy-To-Use Optical Profile Function Program for Modeling...entities into conceptual units was crucial. These units are commonly referred to as (meta)data- dictionaries . The data dictionary concept was important in...considered a book. This is similar to the organization of a dictionary except that books in this model consist of pages which are identically formatted

  16. ONR Far East Scientific Bulletin. Volume 11, Number 2.

    Science.gov (United States)

    1986-06-01

    171 Ar+ ion laser with four dye lasers, and high-power Lambda Physik excimer laser plus dye laser, with Kerr cell switch driven by Ar+ ion laser. .. w...the environment under micro gravity and its applications. The research institute that is involved in electronic dictionaries studies will...of High Performance Surfaces Nippon Kokan 35 Kawasaki Steel Nippon Steel Ishikawajima-Harima Heavy Industries Electronic Dictionaries Fujitsu, Ltd

  17. Surface events in HPGe detectors

    Energy Technology Data Exchange (ETDEWEB)

    Abt, Iris; Dinter, Sabine; Faulstich, Florian; Majorovits, Bela; Stelzer, Franz [Max-Planck-Institut fuer Physik, Munich (Germany)

    2011-07-01

    Events on or close to the surface of high purity germanium, HPGe, detectors can introduce backgrounds in low background applications of such devices. The Galatea test-stand, especially developed and constructed at the MPI fuer Physik allows an almost full surface scan of a detector with alpha and beta sources. Events induced by alpha and beta particles can be characterized and surface effects can be studied. First comparisons between data and Monte Carlo are presented.

  18. Simulation der Laserablation an Metallen

    OpenAIRE

    Ulrich, Christian Markus

    2007-01-01

    Die Zielsetzung der Arbeit ist die Simulation der Absorption von Laserpulsen und der dadurch verursachten thermischen und mechanischen Effekte in Metallen auf Parallelrechnern. Dies sollte geschehen durch die eigenständige Programmierung von Zusatzmodulen für den am Institut für Theoretische und Angewandte Physik gepflegten Molekulardynamik-Code IMD (ITAP Molecular Dynamics) und deren Verwendung zur Untersuchung der ersten ~100 ps von Laserablationsprozessen. Der Quellcode war dazu um Alg...

  19. Test der Speziellen Relativitätstheorie mittels Laserspektroskopie an relativistischen 7 Li +-Ionen am ESR

    OpenAIRE

    Botermann, Benjamin

    2012-01-01

    Die Invarianz physikalischer Gesetze unter Lorentztransformationen ist eines der fundamentalen Postulate der modernen Physik und alle Theorien der grundlegenden Wechselwirkungen sind in kovarianter Form formuliert. Obwohl die Spezielle Relativitätstheorie (SRT) in einer Vielzahl von Experimenten mit hoher Genauigkeit überprüft und bestätigt wurde, sind aufgrund der weitreichenden Bedeutung dieses Postulats weitere verbesserte Tests von grundsätzlichem Interesse. Darüber hinaus weisen moderne ...

  20. Big Bang 8

    CERN Document Server

    Apolin, Martin

    2008-01-01

    Physik soll verständlich sein und Spaß machen! Deshalb beginnt jedes Kapitel in Big Bang mit einem motivierenden Überblick und Fragestellungen und geht dann von den Grundlagen zu den Anwendungen, vom Einfachen zum Komplizierten. Dabei bleibt die Sprache einfach, alltagsorientiert und belletristisch. Band 8 vermittelt auf verständliche Weise Relativitätstheorie, Kern- und Teilchenphysik (und deren Anwendungen in der Kosmologie und Astrophysik), Nanotechnologie sowie Bionik.

  1. Finsler-Geometric Continuum Mechanics

    Science.gov (United States)

    2016-05-01

    Regarding deformation kinematics of Section 2.3, a constitutive equa- tion may be added for specification of transformation matrix ϑaB in Eq. 36, but...Mechanics of Solids. 2012;17:702–735. 24. Clayton J. Aspects of differential geometry and tensor calculus in anholonomic configuration space. In...the calculus of moving sur- faces. New York (NY): Springer; 2013. 59. Truesdell C, Toupin R. The Classical Field Theories. In: Handbuch der Physik

  2. Big Bang 6

    CERN Document Server

    Apolin, Martin

    2008-01-01

    Physik soll verständlich sein und Spaß machen! Deshalb beginnt jedes Kapitel in Big Bang mit einem motivierenden Überblick und Fragestellungen und geht dann von den Grundlagen zu den Anwendungen, vom Einfachen zum Komplizierten. Dabei bleibt die Sprache einfach, alltagsorientiert und belletristisch. Der Band 6 RG behandelt die Gravitation, Schwingungen und Wellen, Thermodynamik und eine Einführung in die Elektrizität anhand von Alltagsbeispielen und Querverbindungen zu anderen Disziplinen.

  3. Big Bang 5

    CERN Document Server

    Apolin, Martin

    2007-01-01

    Physik soll verständlich sein und Spaß machen! Deshalb beginnt jedes Kapitel in Big Bang mit einem motivierenden Überblick und Fragestellungen und geht dann von den Grundlagen zu den Anwendungen, vom Einfachen zum Komplizierten. Dabei bleibt die Sprache einfach, alltagsorientiert und belletristisch. Der Band 5 RG behandelt die Grundlagen (Maßsystem, Größenordnungen) und die Mechanik (Translation, Rotation, Kraft, Erhaltungssätze).

  4. Big Bang 7

    CERN Document Server

    Apolin, Martin

    2008-01-01

    Physik soll verständlich sein und Spaß machen! Deshalb beginnt jedes Kapitel in Big Bang mit einem motivierenden Überblick und Fragestellungen und geht dann von den Grundlagen zu den Anwendungen, vom Einfachen zum Komplizierten. Dabei bleibt die Sprache einfach, alltagsorientiert und belletristisch. In Band 7 werden neben einer Einführung auch viele aktuelle Aspekte von Quantenmechanik (z. Beamen) und Elektrodynamik (zB Elektrosmog), sowie die Klimaproblematik und die Chaostheorie behandelt.

  5. Mikroskopische Thermodynamik kolloidaler Teilchen

    OpenAIRE

    2008-01-01

    Einhergehend mit der industriellen Revolution des 19. Jahrhunderts entwickelte sich ein neues eigenständiges Teilgebiet der Physik, die Thermodynamik. Im Mittelpunkt des Interesses standen damals Wärmekraftmaschinen und das Verständnis der Umwandlung von Wärme in mechanische Arbeit. Im Rahmen der Thermodynamik lassen sich auch chemische Reaktionen oder biologische Prozesse beschreiben. Dabei bleibt sie auf große Systeme beschränkt, wo eine Vielzahl von inneren Freiheitsgraden dazu führt, dass...

  6. Multidisciplinary predialysis education reduced the inpatient and total medical costs of the first 6 months of dialysis in incident hemodialysis patients.

    Directory of Open Access Journals (Sweden)

    Yu-Jen Yu

    Full Text Available The multidisciplinary pre-dialysis education (MPE retards renal progression, reduce incidence of dialysis and mortality of CKD patients. However, the financial benefit of this intervention on patients starting hemodialysis has not yet been evaluated in prospective and randomized trial.We studied the medical expenditure and utilization incurred in the first 6 months of dialysis initiation in 425 incident hemodialysis patients who were randomized into MPE and non-MPE groups before reaching end-stage renal disease. The content of the MPE was standardized in accordance with the National Kidney Foundation Dialysis Outcomes Quality Initiative guidelines.The mean age of study patients was 63.8±13.2 years, and 221 (49.7% of them were men. The mean serum creatinine level and estimated glomerular filtration rate was 6.1±4.0 mg/dL and 7.6±2.9 mL⋅min(-1⋅1.73 m(-2, respectively, at dialysis initiation. MPE patients tended to have lower total medical cost in the first 6 months after hemodialysis initiation (9147.6±0.1 USD/patient vs. 11190.6±0.1 USD/patient, p = 0.003, fewer in numbers [0 (1 vs. 1 (2, p<0.001] and length of hospitalization [0 (15 vs. 8 (27 days, p<0.001], and also lower inpatient cost [0 (2617.4 vs. 1559,4 (5019.6 USD/patient, p<0.001] than non-MPE patients, principally owing to reduced cardiovascular hospitalization and vascular access-related surgeries. The decreased inpatient and total medical cost associated with MPE were independent of patients' demographic characteristics, concomitant disease, baseline biochemistry and use of double-lumen catheter at initiation of hemodialysis.Participation of multidisciplinary education in pre-dialysis period was independently associated with reduction in the inpatient and total medical expenditures of the first 6 months post-dialysis owing to decreased inpatient service utilization secondary to cardiovascular causes and vascular access-related surgeries.ClinicalTrials.gov NCT00644046.

  7. A combination of the QuantiFERON-TB Gold In-Tube assay and the detection of adenosine deaminase improves the diagnosis of tuberculous pleural effusion.

    Science.gov (United States)

    Liu, Yuanyuan; Ou, Qinfang; Zheng, Jian; Shen, Lei; Zhang, Bingyan; Weng, Xinhua; Shao, Lingyun; Gao, Yan; Zhang, Wenhong

    2016-08-03

    The differential diagnosis of tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) remains difficult despite the availability of numerous diagnostic tools. The current study aimed to evaluate the performance of the whole blood QuantiFERON-TB Gold In-Tube (QFT-GIT) assay and conventional laboratory biomarkers in differential diagnosis of TPE and MPE in high tuberculosis prevalence areas. A total of 117 patients with pleural effusions were recruited, including 91 with TPE and 26 with MPE. All of the patients were tested with QFT-GIT, and the conventional biomarkers in both blood and pleural effusion were detected. The level of antigen-stimulated QFT-GIT in the whole blood of TPE patients was significantly higher than that of MPE (2.89 vs 0.33 IU/mL, Pdiagnosis of TPE were 93.0% and 60.0%, respectively. Among the biomarkers in blood and pleural effusion, pleural adenosine deaminase (ADA) was the most prominent biomarker, with a cutoff value of 15.35 IU/L. The sensitivity and specificity for the diagnosis of TPE were 93.4% and 96.2%, respectively. The diagnostic classification tree from the combination of these two biomarkers was 97.8% sensitive and 92.3% specific. Ultimately, the combination of whole blood QFT-GIT with pleural ADA improved both the specificity and positive predictive value to 100%. Thus, QFT-GIT is not superior to pleural ADA in the differential diagnosis of TPE and MPE. Combined whole blood QFT-GIT and pleural ADA detection can improve the diagnosis of TPE.

  8. Management of Pediatric Myxopapillary Ependymoma: The Role of Adjuvant Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Agbahiwe, Harold C.; Wharam, Moody [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Batra, Sachin [Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Cohen, Kenneth [Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Terezakis, Stephanie A., E-mail: sterezak@jhmi.edu [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)

    2013-02-01

    Introduction: Myxopapillary ependymoma (MPE) is a rare tumor in children. The primary treatment is gross total resection (GTR), with no clearly defined role for adjuvant radiation therapy (RT). Published reports, however, suggest that children with MPE present with a more aggressive disease course. The goal of this study was to assess the role of adjuvant RT in pediatric patients with MPE. Methods: Sixteen patients with MPE seen at Johns Hopkins Hospital (JHH) between November 1984 and December 2010 were retrospectively reviewed. Fifteen of the patients were evaluable with a mean age of 16.8 years (range, 12-21 years). Kaplan-Meier curves and descriptive statistics were used for analysis. Results: All patients received surgery as the initial treatment modality. Surgery consisted of either a GTR or a subtotal resection (STR). The median dose of adjuvant RT was 50.4 Gy (range, 45-54 Gy). All patients receiving RT were treated at the involved site. After a median follow-up of 7.2 years (range, 0.75-26.4 years), all patients were alive with stable disease. Local control at 5 and 10 years was 62.5% and 30%, respectively, for surgery alone versus 100% at both time points for surgery and adjuvant RT. Fifty percent of the patients receiving surgery alone had local failure. All patients receiving STR alone had local failure compared to 33% of patients receiving GTR alone. One patient in the surgery and adjuvant RT group developed a distant site of recurrence 1 year from diagnosis. No late toxicity was reported at last follow-up, and neurologic symptoms either improved or remained stable following surgery with or without RT. Conclusions: Adjuvant RT improved local control compared to surgery alone and should be considered after surgical resection in pediatric patients with MPE.

  9. Abnormally High Expression of BAFF on T Lymphocytes from Lung Cancer-associated Pleural Effusions and Its Potent Anti-tumor Effect

    Institute of Scientific and Technical Information of China (English)

    Haiyan XU; Xiaozhou HE; Yibei ZHU; Tiangzan YAN; Hongbin MA; Xueguang ZHANG

    2007-01-01

    In the present study, the expressions of B cell activating factor belonging to the tumor necrosis factor family (BAFF) and its receptors (BAFF-R and TACI) on T lymphocytes from malignant pleural effusion (MPE) were examined by fluorescence-activated cell sorting (FACS) analysis, and compared with those on the T lymphocytes from non-malignant pleural effusion (NMPE) and healthy controls. It was found that CD3 positive T lymphocytes (including CD4, CD8, and part of CD25 and CD69 positive cells) of MPE in lung cancer highly and consistently expressed the BAFF molecule, while high expressions of BAFF could only be found in phytohemagglutinin (PHA) or interleukin 2 (IL-2) induced T lymphocytes from NMPE or healthy controls. These results were consistent with the results from BAFF mRNA detection by real-time PCR. In addition, T lymphocytes from MPE expressed significantly more BAFF-R than those from NMPE or healthy controls, while the expression of TACI was increased on CD4+ T cells but decreased on CD8+ T cells when compared with controls. The Annexin/PI assay suggested that recombinant human BAFF (rhBAFF) could promote the survival rate of T lymphocytes from MPE, while the decoy receptor TACI-Fc fusion protein could promote the apoptosis rate of T lymphocytes. Cytokines in the supernatant detected by ELISA assay showed that rhBAFF could significantly upregulate the secretion of IFN-γ in vitro,and the IFN-γ level in the TACI-Fc-treated group resembled that of the control groups. All of these results indicated that the abnormally high expression of BAFF on T lymphocytes from MPE may play a role of antitumor effect.

  10. Peritoneal mesothelioma: the site of origin matters.

    Science.gov (United States)

    Kindler, Hedy Lee

    2013-01-01

    The etiology, gender distribution, pathology, natural history, and treatment options for mesothelioma (MM) differ substantially depending on the site of origin. Peritoneal mesothelioma (MPeM) is a rare disease, comprising only approximately 10% to 15% of the 2,500 cases of MM diagnosed in the United States each year. Patients with MPeM are younger than patients with pleural MM, and a higher proportion, mostly women, are long-term survivors. Most MPeM is caused by asbestos exposure. Germ-line mutations of BAP1 (BRCA associated protein 1) can predispose to MM, uveal melanoma, and potentially other cancers. MPeM can be challenging to diagnose, and cytology is rarely helpful. Review by an experienced pathologist using a panel of at least two positive and two negative immunohistochemical stains is essential. The three major pathologic subtypes are epithelial, sarcomatoid, and biphasic. Most cases are epithelial; the others have a dismal prognosis. Two indolent subtypes of borderline malignant potential-well-differentiated papillary mesothelioma and benign multicystic mesothelioma-are more common in the peritoneum and are treated surgically. In highly selected patients receiving treatment at experienced referral centers, an aggressive locoregional strategy that combines cytoreductive surgery to remove all gross disease and hyperthermic intraperitoneal chemotherapy to treat residual microscopic tumors yields a 3-year survival of 60% and a median survival approaching 5 years, far better than expected from historic controls. This approach also provides durable palliation of malignant ascites in nearly all patients. Pemetrexed is the only U.S. Food and Drug Administration (FDA)-approved systemic chemotherapy for pleural MM. Largely on the basis of data from pharmaceutical registry studies, the activity of pemetrexed-based chemotherapy appears to be similar in pleural MM and MPeM.

  11. Multidisciplinary predialysis education reduced the inpatient and total medical costs of the first 6 months of dialysis in incident hemodialysis patients.

    Science.gov (United States)

    Yu, Yu-Jen; Wu, I-Wen; Huang, Chun-Yu; Hsu, Kuang-Hung; Lee, Chin-Chan; Sun, Chio-Yin; Hsu, Heng-Jung; Wu, Mai-Szu

    2014-01-01

    The multidisciplinary pre-dialysis education (MPE) retards renal progression, reduce incidence of dialysis and mortality of CKD patients. However, the financial benefit of this intervention on patients starting hemodialysis has not yet been evaluated in prospective and randomized trial. We studied the medical expenditure and utilization incurred in the first 6 months of dialysis initiation in 425 incident hemodialysis patients who were randomized into MPE and non-MPE groups before reaching end-stage renal disease. The content of the MPE was standardized in accordance with the National Kidney Foundation Dialysis Outcomes Quality Initiative guidelines. The mean age of study patients was 63.8±13.2 years, and 221 (49.7%) of them were men. The mean serum creatinine level and estimated glomerular filtration rate was 6.1±4.0 mg/dL and 7.6±2.9 mL⋅min(-1)⋅1.73 m(-2), respectively, at dialysis initiation. MPE patients tended to have lower total medical cost in the first 6 months after hemodialysis initiation (9147.6±0.1 USD/patient vs. 11190.6±0.1 USD/patient, p = 0.003), fewer in numbers [0 (1) vs. 1 (2), pcatheter at initiation of hemodialysis. Participation of multidisciplinary education in pre-dialysis period was independently associated with reduction in the inpatient and total medical expenditures of the first 6 months post-dialysis owing to decreased inpatient service utilization secondary to cardiovascular causes and vascular access-related surgeries. ClinicalTrials.gov NCT00644046.

  12. The hydrolysis kinetics of monobasic and dibasic aminoalkyl esters of ketorolac.

    Science.gov (United States)

    Qandil, Amjad M; Jamhawi, Noor M; Tashtoush, Bassam M; Al-Ajlouni, Ahmad M; Idkaidek, Nasir M; Obaidat, Aiman A

    2013-09-01

    Six aminoethyl and aminobutyl esters of ketorolac containing 1-methylpiperazine (MPE and MPB), N-acetylpiperazine (APE and APB) or morpholine (ME and MB), were synthesized and their hydrolysis kinetics were studied. The hydrolysis was studied at pH 1 to 9 (for MPE, APE and ME) and pH 1 to 8 (for MPB, APB and MB) in aqueous phosphate buffer (0.16 M) with ionic strength (0.5 M) at 37°C. Calculation of k(obs), construction of the pH-rate profiles and determination of the rate equations were performed using KaleidaGraph® 4.1. The hydrolysis displays pseudo-first order kinetics and the pH-rate profiles shows that the aminobutyl esters, MPE, APB and MB, are the most stable. The hydrolysis of the ethyl esters MPE, APE and ME, depending on the pH, is either fast and catalyzed by the hydroxide anion or slow and uncatalyzed for the diprotonated, monoprotonated and nonprotonated forms. The hydrolysis of the butyl esters showed a similar profile, albeit it was also catalyzed by hydronium cation. In addition, the hydroxide anion is 105 more effective in catalyzing the hydrolysis than the hydronium cation. The hydrolysis pattern of the aminoethyl esters is affected by the number and pKa of its basic nitrogen atoms. The monobasic APE and ME, show a similar hydrolysis pattern that is different than the dibasic MPE. The length of the side chain and the pKa of the basic nitrogen atoms in the aminoethyl moiety affect the mechanism of hydrolysis as the extent of protonation at a given pH is directly related to the pKa.

  13. IN VITRO ANTITRYPANOSOMAL EVALUATION OF PICRORHIZA KURROA RHIZOMES

    Directory of Open Access Journals (Sweden)

    Shaba Peter

    2012-07-01

    Full Text Available In this study, Picrorrhiza kurroa rihzomes were cold extracted with methanolic solvent at concentrations (250-1000 μg ml-1. The methanolic plant extract (MPE obtained was tested against Trypanosoma evansi for antitrypanosomal activity. This was carried out on Vero cells grown in Dulbecco's Modified Eagle Medium (DMEM and supplemented with foetal calf serum (FCS 20-40% at appropriate conditions. In vitro cytotoxicity test of P. kurroa rhizomes extract at concentrations (1.56-100 μg ml-1 was done on Vero cells but without FCS. In vivo infectivity test was done in mice. Results of in vitro antitrypanosomal activity varied from immobilization, reduction and to the killing of trypanosomes in corresponding ELISA plate wells. At 750 μg ml-1of MPE, there was marked reduction of average mean trypanosomes count in the corresponding ELISA plate wells as observed (39.00±0.0to 19.00±0.0. But at 1000 μg ml-1 of the test extract of P. kurroa, there was complete killing of trypanosomes at 8 h of incubation, which was comparable to diminazine aceturate (50 μg ml-1 at 4 h. Trypanosomes counts decreased in concentration and time –dependent manner with significant difference (P<0.05. MPE of P. kurroa and diminazine aceturate, standard drug, were cytotoxic to Vero cells except at concentrations of 1.56-6. 25 μg ml-1. Both MPE and diminazine aceturate had the same cytotoxic levels. Group of mice inoculated with contents of ELISA plate wells with apparently killed trypanosomes survived for more than 30 days. While, the other group of mice inoculated with contents of ELISA plate wells with reduced trypanosomes died of parasitaemia. Moderate antitrypanosmal activity of MPE of P. kurroa was observed.

  14. Growth Inhibition and Morphological Alteration of Fusarium sporotrichioides by Mentha piperita Essential Oil.

    Science.gov (United States)

    Rachitha, P; Krupashree, K; Jayashree, G V; Gopalan, Natarajan; Khanum, Farhath

    2017-01-01

    The aim of this study is to determine the phytochemical composition, antifungal activity of Mentha piperita essential oil (MPE) against Fusarium sporotrichioides. The phytochemical composition was conducted by gas chromatography mass spectrometry (GC MS) analysis and mycelia growth inhibition was determined by minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), the morphological characterization was observed by scanning electron microscopy. Finally, the membrane permeability was determined by the release of extracellular constituents, pH, and total lipid content. In GC MS analysis, 22 metabolites were identified such as menthol, l menthone, pulegone, piperitone, caryophyllene, menthol acetate, etc. The antifungal activity against targeted pathogen, with MIC and MFC 500 μg/mL and 1000 μg/mL, respectively. The MPE altered the morphology of F. sporotrichoides hyphae with the loss of cytoplasm content and contorted the mycelia. The increasing concentration of MPE showed increase in membrane permeability of F. sporotrichoides as evidenced by the release of extracellular constituents and pH with the disruption of cell membrane indicating decrease in lipid content of F. sporotrichoides. The observed results showed that MPE exhibited promising new antifungal agent against Fusarium sporotrichioides. F. sporotrichioides, filamentous fungi contaminate to corn and corn--based productsF. sporotrichioides mainly responsible for the production of T-2 toxinPhytochemical composition was conducted by gas chromatography--mass spectrometry analysisMentha piperita essential oil (MPE) is commonly known as peppermintThe F. sporotrichioides growth was inhibited by MPE (minimum inhibitory concentration, minimum fungicidal concentration)Morphological observation by scanning electron microscope. Abbreviations Used: Cfu: Colony forming unit; DMSO: Dimethyl sulfoxide, °C: Degree celsius; F. Sporotrichoides: Fusarium sporotrichioides; EOs: Essential oils; M

  15. Growth Inhibition and Morphological Alteration of Fusarium sporotrichioides by Mentha piperita Essential Oil

    Science.gov (United States)

    Rachitha, P.; Krupashree, K.; Jayashree, G. V.; Gopalan, Natarajan; Khanum, Farhath

    2017-01-01

    Objective: The aim of this study is to determine the phytochemical composition, antifungal activity of Mentha piperita essential oil (MPE) against Fusarium sporotrichioides. Methods: The phytochemical composition was conducted by gas chromatography mass spectrometry (GC MS) analysis and mycelia growth inhibition was determined by minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), the morphological characterization was observed by scanning electron microscopy. Finally, the membrane permeability was determined by the release of extracellular constituents, pH, and total lipid content. Result: In GC MS analysis, 22 metabolites were identified such as menthol, l menthone, pulegone, piperitone, caryophyllene, menthol acetate, etc. The antifungal activity against targeted pathogen, with MIC and MFC 500 μg/mL and 1000 μg/mL, respectively. The MPE altered the morphology of F. sporotrichoides hyphae with the loss of cytoplasm content and contorted the mycelia. The increasing concentration of MPE showed increase in membrane permeability of F. sporotrichoides as evidenced by the release of extracellular constituents and pH with the disruption of cell membrane indicating decrease in lipid content of F. sporotrichoides. Conclusion: The observed results showed that MPE exhibited promising new antifungal agent against Fusarium sporotrichioides. SUMMARY F. sporotrichioides, filamentous fungi contaminate to corn and corn--based productsF. sporotrichioides mainly responsible for the production of T-2 toxinPhytochemical composition was conducted by gas chromatography--mass spectrometry analysisMentha piperita essential oil (MPE) is commonly known as peppermintThe F. sporotrichioides growth was inhibited by MPE (minimum inhibitory concentration, minimum fungicidal concentration)Morphological observation by scanning electron microscope. Abbreviations Used: Cfu: Colony forming unit; DMSO: Dimethyl sulfoxide, °C: Degree celsius; F. Sporotrichoides

  16. Analysis on the use of vacuum oven for the indirect slumping of glass x-ray mirror segments

    Science.gov (United States)

    Madarasz, Emanuel; Proserpio, Laura; Breunig, Elias; Friedrich, Peter

    2016-07-01

    The Max-Planck-Institute for Extraterrestrial Physics (MPE) is involved in the investigation and optimization of the indirect slumping technique for the manufacturing of thin glass mirror segments to be assembled in lightweight X-ray telescopes. During the last year, we started to analyze the influence of vacuum environment on the results of this thermal forming process. The realization of slumping in vacuum offers theoretically several advantages, like the absence of air between the glass and the mold and a cleaner process chamber. Furthermore, the heat exchange is different with respect to a standard air-oven and this might have positive effects during the important heating and cooling phases of the process. All these aspects will be considered in the paper and the current status in the development of the MPE vacuum-slumping approach will be outlined.

  17. QPS/LHC Activities requiring important Tunnel Work During a future long Shutdown

    CERN Document Server

    Dahlerup-Petersen, K

    2011-01-01

    The MPE/circuit protection section is presently establishing a road map for its future LHC activities. The tasks comprise essential consolidation work, compulsory upgrades and extensions of existing machine facilities. The results of a first round of engineering exertion were presented and evaluated at a MPE activity review in December 2010. The technical and financial aspects of this program will be detailed in the ‘QPS Medium and Long-Term Improvement Plan’, to be published shortly. The QPS activities in the LHC tunnel during a future, long shutdown are closely related to this improvement chart. A project-package based program for the interventions has been established and will be presented in this report, together with estimates for the associated human and financial resources necessary for its implementation.

  18. Genetic transformation of marine cyanobacterium Synechococcus sp. CC9311 (Cyanophyceae) by electroporation

    Science.gov (United States)

    Chen, Huaxin; Lin, Hanzhi; Jiang, Peng; Li, Fuchao; Qin, Song

    2013-03-01

    Synechococcus sp. CC9311 is a marine cyanobacterium characterized by type IV chromatic acclimation (CA). A genetic transformation system was developed as a first step to elucidate the molecular mechanism of CA. The results show that Synechococcus sp. CC9311 cells were sensitive to four commonly used antibiotics: ampicillin, kanamycin, spectinomycin, and chloramphenicol. An integrative plasmid to disrupt the putative phycoerythrin lyase gene mpeV, using a kanamycin resistance gene as selectable marker, was constructed by recombinant polymerase chain reaction. The plasmid was then transformed into Synechococcus sp. CC9311 via electroporation. High transformation efficiency was achieved at a field strength of 2 kV/cm. DNA analysis showed that mpeV was fully disrupted following challenge of the transformants with a high concentration of kanamycin. In addition, the transformants that displayed poor growth on agar SN medium could be successfully plated on agarose SN medium.

  19. Phagocytosis-inspired behaviour in synthetic protocell communities of compartmentalized colloidal objects

    Science.gov (United States)

    Rodríguez-Arco, Laura; Li, Mei; Mann, Stephen

    2017-08-01

    The spontaneous assembly of micro-compartmentalized colloidal objects capable of controlled interactions offers a step towards rudimentary forms of collective behaviour in communities of artificial cell-like entities (synthetic protocells). Here we report a primitive form of artificial phagocytosis in a binary community of synthetic protocells in which multiple silica colloidosomes are selectively ingested by self-propelled magnetic Pickering emulsion (MPE) droplets comprising particle-free fatty acid-stabilized apertures. Engulfment of the colloidosomes enables selective delivery and release of water-soluble payloads, and can be coupled to enzyme activity within the MPE droplets. Our results highlight opportunities for the development of new materials based on consortia of colloidal objects, and provide a novel microscale engineering approach to inducing higher-order behaviour in mixed populations of synthetic protocells.

  20. A simple and efficient algorithm for gene selection using sparse logistic regression.

    Science.gov (United States)

    Shevade, S K; Keerthi, S S

    2003-11-22

    This paper gives a new and efficient algorithm for the sparse logistic regression problem. The proposed algorithm is based on the Gauss-Seidel method and is asymptotically convergent. It is simple and extremely easy to implement; it neither uses any sophisticated mathematical programming software nor needs any matrix operations. It can be applied to a variety of real-world problems like identifying marker genes and building a classifier in the context of cancer diagnosis using microarray data. The gene selection method suggested in this paper is demonstrated on two real-world data sets and the results were found to be consistent with the literature. The implementation of this algorithm is available at the site http://guppy.mpe.nus.edu.sg/~mpessk/SparseLOGREG.shtml Supplementary material is available at the site http://guppy.mpe.nus.edu.sg/~mpessk/SparseLOGREG.shtml

  1. Effect of synthetic mica on the thermal properties of poly(lactic acid

    Directory of Open Access Journals (Sweden)

    Diego Holanda Saboya Souza

    2014-01-01

    Full Text Available Poly(lactic acid/Somasif fluoromica nanocomposites were prepared by melt blending and their thermal properties investigated by DSC, TGA and DMA. Three different types of synthetic mica (Somasif ME-100, Somasif MAE and Somasif MPE were used at different contents (2.5, 5.0 and 7.5 wt %. The melt blending of PLA and these micas is characterized by a considerable reduction in the matrix molecular weight, which decreases when the nanofiller content is increased. For all nanocomposites, the thermal stability increases when mica is added to the polymer, with the Somasif MPE, producing the highest increase of the degradation temperature and highest reduction of Tg.

  2. Photodynamic therapy with ultrafast lasers

    Science.gov (United States)

    Wachter, Eric A.; Petersen, Mark G.; Dees, Craig

    1999-06-01

    The photodynamic properties of several photosensitive compounds have been evaluated in vivo using simultaneous two-photon excitation (TPE) and multi-photon excitation (MPE). TPE and MPE are effected using a mode-locked laser, such as the mode-locked titanium:sapphire or Nd:YLF laser, the near infrared output of which allows direct promotion of various non-resonant transitions. Such lasers are exceptionally well suited for non-linear activation of exogenous or endogenous PDT agents in biological systems due to their extremely short pulse width, modest pulse energy, and high repetition rate; these features combine to effect efficient PDT activation with minimal potential for non- specific biological damage, improved spatial localization of activation, and enhanced depth of penetration. Results in several murine models are presented.

  3. Cross-Validation of a Glucose-Insulin-Glucagon Pharmacodynamics Model for Simulation using Data from Patients with Type 1 Diabetes

    DEFF Research Database (Denmark)

    Wendt, Sabrina Lyngbye; Ranjan, Ajenthen; Møller, Jan Kloppenborg

    2017-01-01

    and glucagon on EGP. Bias and precision of PD model test fits were assessed by mean predictive error (MPE) and mean absolute predictive error (MAPE). Results: Assuming constant variables in a subject across nonoutlier visits and using thresholds of ±15% MPE and 20% MAPE, we accepted at least one and at most......Background: Currently, no consensus exists on a model describing endogenous glucose production (EGP) as a function of glucagon concentrations. Reliable simulations to determine the glucagon dose preventing or treating hypoglycemia or to tune a dual-hormone artificial pancreas control algorithm need...... a validated glucoregulatory model including the effect of glucagon. Methods: Eight type 1 diabetes (T1D) patients each received a subcutaneous (SC) bolus of insulin on four study days to induce mild hypoglycemia followed by a SC bolus of saline or 100, 200, or 300 µg of glucagon. Blood samples were analyzed...

  4. High IL-35 Pleural Expression in Patients with Tuberculous Pleural Effusion

    OpenAIRE

    2015-01-01

    Background IL-35 is a novel anti-inflammatory and immunosuppressive cytokine primarily produced by Treg cells, and is involved in inflammatory diseases and autoimmune diseases. However, its roles in tuberculous pleural effusion (TPE) remain unknown. We aimed to investigate the potential involvement of IL-35 in TPE. Material/Methods Thirty TPE patients and 20 lung cancer patients with malignant pleural effusion (MPE) were recruited. Samples of pleural effusion (100 mL) were collected after tra...

  5. Phycoerythrin-specific bilin lyase-isomerase controls blue-green chromatic acclimation in marine Synechococcus.

    Science.gov (United States)

    Shukla, Animesh; Biswas, Avijit; Blot, Nicolas; Partensky, Frédéric; Karty, Jonathan A; Hammad, Loubna A; Garczarek, Laurence; Gutu, Andrian; Schluchter, Wendy M; Kehoe, David M

    2012-12-04

    The marine cyanobacterium Synechococcus is the second most abundant phytoplanktonic organism in the world's oceans. The ubiquity of this genus is in large part due to its use of a diverse set of photosynthetic light-harvesting pigments called phycobiliproteins, which allow it to efficiently exploit a wide range of light colors. Here we uncover a pivotal molecular mechanism underpinning a widespread response among marine Synechococcus cells known as "type IV chromatic acclimation" (CA4). During this process, the pigmentation of the two main phycobiliproteins of this organism, phycoerythrins I and II, is reversibly modified to match changes in the ambient light color so as to maximize photon capture for photosynthesis. CA4 involves the replacement of three molecules of the green light-absorbing chromophore phycoerythrobilin with an equivalent number of the blue light-absorbing chromophore phycourobilin when cells are shifted from green to blue light, and the reverse after a shift from blue to green light. We have identified and characterized MpeZ, an enzyme critical for CA4 in marine Synechococcus. MpeZ attaches phycoerythrobilin to cysteine-83 of the α-subunit of phycoerythrin II and isomerizes it to phycourobilin. mpeZ RNA is six times more abundant in blue light, suggesting that its proper regulation is critical for CA4. Furthermore, mpeZ mutants fail to normally acclimate in blue light. These findings provide insights into the molecular mechanisms controlling an ecologically important photosynthetic process and identify a unique class of phycoerythrin lyase/isomerases, which will further expand the already widespread use of phycoerythrin in biotechnology and cell biology applications.

  6. Force Limited Vibration Testing and Subsequent Redesign of the Naval Postgraduate School CubeSat Launcher

    Science.gov (United States)

    2014-06-01

    piezoelectric JPL Jet Propulsion Laboratory LV launch vehicle MPE maximum predicted environment xvi NASA National Aeronautics and Space Administration...in San Luis Obispo [1]. Each P-POD can carry anywhere from one to three CubeSats, depending on the CubeSat size, giving NPSCuL the capability of...University, San Luis Obispo, CA, 2007. [2] S. Lee, A. Hutputanasin, A. Toorian, W. Lan and R. Munakata, “CubeSat design specification (revision 12

  7. Does Marriage Make Us Healthier? Inter-Country Comparative Evidence from China, Japan, and Korea.

    Science.gov (United States)

    Fu, Rong; Noguchi, Haruko

    2016-01-01

    This study focuses on East Asian countries and investigates the difference in the marriage premium on the health-marriage protection effect (MPE) between younger and older generations and the intra-couple education concordance effect (ECE) on the health of married individuals. This study used inter-country comparative data from China, Japan, and Korea. This study focused on individuals (n = 7,938) in China, Japan, and Korea who were sampled from the 2010 East Asian Social Survey. To investigate MPE and ECE, four health indicators were utilized: a physical and mental components summary (PCS and MCS), self-rated health status (Dself), and happiness level (Dhappy). Ordinary least squares regression was conducted by country- and gender-specific subsamples. We found that the MPE on PCS, MCS, and Dself was more significant for the older generation than for the younger generation in both China and Japan, whereas the results were inconclusive in Korea. With regard to the ECE on happiness (Dhappy), for both men and women, couples tend to be happier when both the husband and the wife are well educated ("higher balanced marriage") compared to couples with a lower level of educational achievement ("lower balanced marriage"). Significant benefits from a "higher balanced marriage" on MCS and Dself were observed for women only. In contrast, no statistically significant differences in health status were observed between "higher balanced marriage" couples and couples with different levels of educational achievements ("upward marriage" or "downward marriage"). This study found that (1) the MPE was more significant for the older generation, and (2) the health gap, particularly the happiness gap, between higher- and lower-balanced married couples was significant. The inter-country comparative findings are useful to explain how the role of marriage (and therefore of family) on health has been diluted due to the progress of industrialization and modernization.

  8. Current practices in the management of malignant pleural effusions: a survey among members of the European Society of Thoracic Surgeons.

    Science.gov (United States)

    Scarci, Marco; Caruana, Edward; Bertolaccini, Luca; Bedetti, Benedetta; Brunelli, Alessandro; Varela, Gonzalo; Papagiannopoulos, Kostas; Kuzdzal, Jaroslaw; Massard, Gilbert; Ruffini, Enrico; Falcoz, Pierre Emmanuel; Opitz, Isabelle; Batirel, Hasan; Toker, Alper; Rocco, Gaetano

    2017-03-01

    Malignant pleural effusion (MPE) commonly complicates advanced malignancy and their exact management is still undefined. We undertook a survey to determine the current practice among members of the European Society of Thoracic Surgeons (ESTS). A cross-sectional survey focused on the current practice of management of MPE was developed by the authors. The questions were outlined after a review of the literature and circulated in an Internet-based survey format. Computed tomography (125, 92%) and chest X-ray (106, 78%) are the most common imaging modalities performed in the initial evaluation. Video-assisted thoracoscopic surgery for washout and pleurodesis (93, 68%) was reported as the preferred approach to patients with uncomplicated MPE. Sixty-one (45%) of the responding colleagues routinely use large bore chest tubes for draining malignant effusions. Forty-nine (35%) surgeons would not apply suction to the drainage system, whilst 50 (37%) would use -2 kPa or less. Talc (124, 91%) is the most commonly used sclerosing agent for pleurodesis in the context of malignant pleural effusion. The practice of 76 (56%) of the respondents is not informed by any clinical guidelines, whilst 60 (44%) reported adhering to the 2010 British Thoracic Society Pleural Disease Guideline. Seventy-one (52%) declared that the guidance was in need of updating or revision. This survey demonstrates the lacking adoption of the existing clinical guidance in this field, as well as the need for more contemporary guidelines for a better-informed practice. The ESTS Working Group on the management of MPE has been established for this purpose.

  9. Síntese, caracterização e avaliação da atividade antimicrobiana de complexos derivados de ligantes (N, S, O) ambidentados

    OpenAIRE

    Berlini, Lilian

    2012-01-01

    No presente trabalho foram sintetizados os ligantes mercaptopirimidilmetano (mpm), mercaptopirimidiletano (mpe), mercaptopirimidilbutano (mpb) e mercaptopirimidilexano (mph). A partir destes ligantes foram obtidos complexos de cobre(II). Os complexos obtidos com os três primeiros ligantes apresentaram estequiometria 1:1(M:L) e geometria bipiramidal trigonal distorcida, e o complexo obtido com o mph apresentou estequiometria 2:3 (M:L). Dois compostos de zinco(II) foram sintetizados com os liga...

  10. Does Marriage Make Us Healthier? Inter-Country Comparative Evidence from China, Japan, and Korea.

    Directory of Open Access Journals (Sweden)

    Rong Fu

    Full Text Available This study focuses on East Asian countries and investigates the difference in the marriage premium on the health-marriage protection effect (MPE between younger and older generations and the intra-couple education concordance effect (ECE on the health of married individuals. This study used inter-country comparative data from China, Japan, and Korea.This study focused on individuals (n = 7,938 in China, Japan, and Korea who were sampled from the 2010 East Asian Social Survey. To investigate MPE and ECE, four health indicators were utilized: a physical and mental components summary (PCS and MCS, self-rated health status (Dself, and happiness level (Dhappy. Ordinary least squares regression was conducted by country- and gender-specific subsamples.We found that the MPE on PCS, MCS, and Dself was more significant for the older generation than for the younger generation in both China and Japan, whereas the results were inconclusive in Korea. With regard to the ECE on happiness (Dhappy, for both men and women, couples tend to be happier when both the husband and the wife are well educated ("higher balanced marriage" compared to couples with a lower level of educational achievement ("lower balanced marriage". Significant benefits from a "higher balanced marriage" on MCS and Dself were observed for women only. In contrast, no statistically significant differences in health status were observed between "higher balanced marriage" couples and couples with different levels of educational achievements ("upward marriage" or "downward marriage".This study found that (1 the MPE was more significant for the older generation, and (2 the health gap, particularly the happiness gap, between higher- and lower-balanced married couples was significant. The inter-country comparative findings are useful to explain how the role of marriage (and therefore of family on health has been diluted due to the progress of industrialization and modernization.

  11. Management of malignant pleural effusion

    OpenAIRE

    Boshuizen, R.C.

    2017-01-01

    The first part of this thesis focuses on IPCs (indwelling pleural catheters) in malignant pleural effusion (MPE) management. In an invited review, the (dis)advantages and prejudices of IPCs are described (Chapter1.1). Since costs and reimbursement issues are the main reasons in the Netherlands to withhold patients from IPCs, we performed a retrospective analysis of a prospectively collected database. In this database, we registered patient characteristics (gender, tumor type), survival data a...

  12. Predicting survival in malignant pleural effusion: development and validation of the LENT prognostic score.

    Science.gov (United States)

    Clive, Amelia O; Kahan, Brennan C; Hooper, Clare E; Bhatnagar, Rahul; Morley, Anna J; Zahan-Evans, Natalie; Bintcliffe, Oliver J; Boshuizen, Rogier C; Fysh, Edward T H; Tobin, Claire L; Medford, Andrew R L; Harvey, John E; van den Heuvel, Michel M; Lee, Y C Gary; Maskell, Nick A

    2014-12-01

    Malignant pleural effusion (MPE) causes debilitating breathlessness and predicting survival is challenging. This study aimed to obtain contemporary data on survival by underlying tumour type in patients with MPE, identify prognostic indicators of overall survival and develop and validate a prognostic scoring system. Three large international cohorts of patients with MPE were used to calculate survival by cell type (univariable Cox model). The prognostic value of 14 predefined variables was evaluated in the most complete data set (multivariable Cox model). A clinical prognostic scoring system was then developed and validated. Based on the results of the international data and the multivariable survival analysis, the LENT prognostic score (pleural fluid lactate dehydrogenase, Eastern Cooperative Oncology Group (ECOG) performance score (PS), neutrophil-to-lymphocyte ratio and tumour type) was developed and subsequently validated using an independent data set. Risk stratifying patients into low-risk, moderate-risk and high-risk groups gave median (IQR) survivals of 319 days (228-549; n=43), 130 days (47-467; n=129) and 44 days (22-77; n=31), respectively. Only 65% (20/31) of patients with a high-risk LENT score survived 1 month from diagnosis and just 3% (1/31) survived 6 months. Analysis of the area under the receiver operating curve revealed the LENT score to be superior at predicting survival compared with ECOG PS at 1 month (0.77 vs 0.66, pLENT scoring system is the first validated prognostic score in MPE, which predicts survival with significantly better accuracy than ECOG PS alone. This may aid clinical decision making in this diverse patient population. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  13. Constraints on gamma-ray line and continuum emission from the Galactic Center Region at MeV Energies

    Energy Technology Data Exchange (ETDEWEB)

    Diehl, R.; v. Ballmoos, P.; Schoenfelder, V.

    1988-09-25

    MPE Compton Telescope observations of MeV radiation from the direction of the Galactic Center lead to constraints on the central source and on diffuse processes in the Galaxy: The extent of 1.8 MeV line emission from /sup 26/Al suggests an /sup 26/Al production process with pronounced concentration towards the Galactic Center. The absence of other ..gamma..-ray lines constrains nucleosynthesis and cosmic ray excitation parameters in the Galaxy.

  14. Phycoerythrin Signatures in the Littoral Zone

    Science.gov (United States)

    2007-09-30

    adaptation, previously unreported in cyanobacteria (Everroad & Six et al., 2006). However, we also found that these strains co-occurred in a diverse...traditionally used provide resolution of the phylogenetic history of prokaryotes as several levels or resolution. The third genetic marker we use are the co...indication of phylogenetic history and identify strains with common ancestry. As noted earlier, we sequenced the cpeBA and mpeBA genes because they

  15. Robotic Laser Coating Removal System

    Science.gov (United States)

    2008-07-01

    reference to ASTM  C393, Standard Test Method for Flexural Properties of  Sandwich  Constructions.  Flexure testing  of  aluminum  honeycomb   specimens...Amplification by Stimulated Emission of Radiation LHMEL Laser Hardened Materials Evaluation Laboratory MPE Maximum Permissible Exposure N2 Nitrogen NASA ...Army, Navy, Marine Corps, and National Aeronautics and Space Administration ( NASA ). In this Environmental Security Technology Certification

  16. Hyperstress

    DEFF Research Database (Denmark)

    Baldursson, Einar Baldvin

    Stress er et stort problem i vores moderne hverdag med det moderne arbejdsliv, der konstant kræver omstillingsparathed. Alligevel forsøger vi at finde 'gamle' og traditionelle løsninger på, hvordan vi skal bekæmpe stress. Denne bog forslår i stedet, at vi finder en ny, fremadrettet forståelse af...

  17. Markforsøg med ukrudtsbekæmpelse i spinat

    DEFF Research Database (Denmark)

    Hartvig, Peter; Madsen, Lis; Sørensen, Jakob

    2012-01-01

    opdagelsen af, at clomazon (Command CS) er selektiv i spinat. Der er udført mange forsøg med clomazon, og i dag udgør Command CS standardbehandlingen i næsten alle spinatmarker. Forsøgene har også vist, at vi har brug for flere herbicider til at bekæmpe vanskelige ukrudtsarter. Især har vi behov for et...

  18. Operation of the power system 2011; Driften av kraftsystemet 2011

    Energy Technology Data Exchange (ETDEWEB)

    Brekke, Karstein; Ulsberg, Helge

    2012-07-01

    This report has been prepared as a result of the allotment letters for 2012 to the Norwegian Water Resources and Energy Directorate (NVE) of Petroleum and Energy (MPE), which imposes NVE to prepare an annual report on the operation of the power system. The report shall include information and analysis related to the state of the power system, including errors in key transmission links within Norway and abroad. (Author)

  19. Autonomous and Connected Vehicles: A Law Enforcement Primer

    Science.gov (United States)

    2015-12-01

    journals/ mpe/2014/467165/abs/. 38 Android Auto app and Apple’s CarPlay app . Each will allow safe use of cellular devices through the vehicle’s...Vehicles,” 294. 129 Pedro Daniel Urbina Coronado et al., “Development of an Android OS Based Controller of a Double Motor Propulsion System for...Connected Vehicles,” 294. 131 Johan Wideberg, Pablo Luque, and Daniel Mantaras, “A Smartphone Application to Extract Safety and Environmental Related

  20. Spinal tuberculoma in a patient with spinal myxopapillary ependymoma

    Directory of Open Access Journals (Sweden)

    Arora Brijesh

    2010-01-01

    Full Text Available Intramedullary spinal tuberculosis is a clinical curiosity. A 19-year-old female was diagnosed and treated for lumbosacral myxopapllary ependy moma (MPE. Three years later, she presented with back pain and hypoesthesia of the left upper limb. Besides revealing local recurrence, the MRI demonstrated a fresh lesion in the cervicomedullary area. The latter was operated and the histopathology revealed a tuberculoma.

  1. Ferromagnetic Resonance and Spin Hall Torque for Nanometric Thick Magnetic Insulator |Normal Metal Bilayers System

    OpenAIRE

    2014-01-01

    In bilayer system, consists of ferromagnetic insulator, high spin orbit coupling normal metal (FM|NM), a new ferromagnetic resonance (FMR) damping that depends on varying the thickness of the normal metal observed. This new enhancement in the damping attributed to magnetic proximity effect (MPE) at the interface, which is verified by the increases in the real part of spin mixing conductance. Spin pumping phenomena occurs when pure spin current can flow into the normal metal when the ferromagn...

  2. Syd for Rom

    DEFF Research Database (Denmark)

    Frandsen, Steen Bo

    land til et uvejsomt malariabefængt øde. Adskillige forsøg på at komme sumpen til livs mislykkedes. Først da det blev muligt at bekæmpe malariaen, skete der fremskridt. Opdyrkningen blev endeligt gennemført under Mussolini, der gjorde det nye land til symbol på fascismens Italien og menneskets sejr...

  3. Initialization and Restart in Stochastic Local Search: Computing a Most Probable Explanation in Bayesian Networks

    Science.gov (United States)

    Mengshoel, Ole J.; Wilkins, David C.; Roth, Dan

    2010-01-01

    For hard computational problems, stochastic local search has proven to be a competitive approach to finding optimal or approximately optimal problem solutions. Two key research questions for stochastic local search algorithms are: Which algorithms are effective for initialization? When should the search process be restarted? In the present work we investigate these research questions in the context of approximate computation of most probable explanations (MPEs) in Bayesian networks (BNs). We introduce a novel approach, based on the Viterbi algorithm, to explanation initialization in BNs. While the Viterbi algorithm works on sequences and trees, our approach works on BNs with arbitrary topologies. We also give a novel formalization of stochastic local search, with focus on initialization and restart, using probability theory and mixture models. Experimentally, we apply our methods to the problem of MPE computation, using a stochastic local search algorithm known as Stochastic Greedy Search. By carefully optimizing both initialization and restart, we reduce the MPE search time for application BNs by several orders of magnitude compared to using uniform at random initialization without restart. On several BNs from applications, the performance of Stochastic Greedy Search is competitive with clique tree clustering, a state-of-the-art exact algorithm used for MPE computation in BNs.

  4. Reproductive, Growth Performance and Nutrient Utilization of Heterobranchus bidorsalis (Geoffroy, 1809 and its Hybrid Clariabranchus Induced with Synthetic Hormone and Pituitary Gland of Heterobranchus bidorsalis

    Directory of Open Access Journals (Sweden)

    M.A. Anetekhai

    2011-01-01

    Full Text Available This study was conducted to assess the reproductive performance, growth rate and nutrient utilization capacities of pure breed Heterobranchus bidorsalis (H. bidorsalis ? x H. bidorsalis ? and its hybrid (H. bidorsalis ? x C. gariepinus ? (Clariabranchus induced with synthetic hormone (ovaprim and pituitary of male and female Heterobranchus bidorsalis. In this study, 3 female Heterobranchus bidorsalis, 3 male Heterobranchus bidorsalis and 3 male Clarias gariepinus were used for the experiment. One female H. bidorsalis induced with ovaprim produced eggs which were divided into two equal halves. Each half was fertilized separately by milt from H. bidorsalis and C. gariepinus to produce pure breed and hybrid, respectively. A similar crossing was done for the female H. bidorsalis induced with Male Pituitary Extract (MPE and Female Pituitary Extract (FPE. Percentage fertilization and hatching rate of pure breed induced with ovaprim were significantly (p<0.05 higher than the other genetic crosses. The highest values for weight gain (5.461.58 g, average daily growth (0.390.11 g and specific growth rate (1.040.16%/day occurred in pure breed induced with MPE. The lowest values for these growth parameters were obtained in the hybrid induced with FPE. Feed intake, protein intake, feed conversion ratio and protein efficiency ratio varied significantly (p<0.05 among the treatments. This study has shown that the pure breeds and hybrids induced with ovaprim and MPE performed better than those induced with FPE. Therefore, they are recommended for commercial aquaculture.

  5. Microwave-Assisted Surface Modification of Metallocene Polyethylene for Improving Blood Compatibility

    Directory of Open Access Journals (Sweden)

    Hemanth Mohandas

    2013-01-01

    Full Text Available A wide number of polymers are being used for various medical applications. In this work, microwave-assisted surface modification of metallocene polyethylene (mPE was studied. FTIR analysis showed no significant changes in the chemical groups after treatment. Contact angle analysis revealed a decrease in contact angle of the treated samples insinuating increasing hydrophilicity and better biocompatibility. Qualitative analysis of treated samples using scanning electron microscope (SEM depicted increasing surface roughness and holes formation further corroborating the results. Coagulation assays performed for estimating prothrombin time (PT and activated partial thromboplastin time (APTT showed an increase in the clotting time which further confirmed the improved blood compatibility of the microwave-treated surfaces. Further, the extent of hemolysis in the treated sample was lower than the untreated one. Hence, microwave-assisted surface modification of mPE resulted in enhanced blood compatibility. Improved blood compatibility of mPE may be exploited for fabrication of artificial vascular prostheses, implants, and various blood contacting devices.

  6. Effect of dietary ethanol extracts of mango (Mangifera indica L.) on lipid oxidation and the color of chicken meat during frozen storage.

    Science.gov (United States)

    Freitas, Ednardo Rodrigues; da Silva Borges, Ângela; Pereira, Ana Lúcia Fernandes; Abreu, Virgínia Kelly Gonçalves; Trevisan, Maria Teresa Salles; Watanabe, Pedro Henrique

    2015-12-01

    The aim of this study was to evaluate the dietary effect of mango extracts on lipid stability and the coloring of broiler chicken breast meat during frozen storage. The treatments consisted of broiler chicken diet without antioxidants (control) and diets containing antioxidants: 200 ppm of butylated hydroxytoluene (BHT), 200 ppm of mango peel extract (MPE), 400 ppm of MPE, 200 ppm of mango seed extract (MSE), and 400 ppm of MSE. The broiler breasts were stored for 90 days and analysis of lipid oxidation and color was performed every 30 days. The thiobarbituric acid reactive substances values increased during storage and at 90 days, but the 400 ppm MSE treatment yielded lower values, indicating greater antioxidant activity. During storage, the lightness values decreased and the redness increased. Additions of 200 ppm BHT and 400 ppm MPE increased yellowness at 60 days of storage. Thus, mango peel and seed extracts added to broiler chicken diets reduce lipid oxidation and maintain color in breast meat during frozen storage, with mango seed extract at 400 ppm being the most effective. © 2015 Poultry Science Association Inc.

  7. Multiscale Permutation Entropy Based Rolling Bearing Fault Diagnosis

    Directory of Open Access Journals (Sweden)

    Jinde Zheng

    2014-01-01

    Full Text Available A new rolling bearing fault diagnosis approach based on multiscale permutation entropy (MPE, Laplacian score (LS, and support vector machines (SVMs is proposed in this paper. Permutation entropy (PE was recently proposed and defined to measure the randomicity and detect dynamical changes of time series. However, for the complexity of mechanical systems, the randomicity and dynamic changes of the vibration signal will exist in different scales. Thus, the definition of MPE is introduced and employed to extract the nonlinear fault characteristics from the bearing vibration signal in different scales. Besides, the SVM is utilized to accomplish the fault feature classification to fulfill diagnostic procedure automatically. Meanwhile, in order to avoid a high dimension of features, the Laplacian score (LS is used to refine the feature vector by ranking the features according to their importance and correlations with the main fault information. Finally, the rolling bearing fault diagnosis method based on MPE, LS, and SVM is proposed and applied to the experimental data. The experimental data analysis results indicate that the proposed method could identify the fault categories effectively.

  8. A moment-convergence method for stochastic analysis of biochemical reaction networks

    Science.gov (United States)

    Zhang, Jiajun; Nie, Qing; Zhou, Tianshou

    2016-05-01

    Traditional moment-closure methods need to assume that high-order cumulants of a probability distribution approximate to zero. However, this strong assumption is not satisfied for many biochemical reaction networks. Here, we introduce convergent moments (defined in mathematics as the coefficients in the Taylor expansion of the probability-generating function at some point) to overcome this drawback of the moment-closure methods. As such, we develop a new analysis method for stochastic chemical kinetics. This method provides an accurate approximation for the master probability equation (MPE). In particular, the connection between low-order convergent moments and rate constants can be more easily derived in terms of explicit and analytical forms, allowing insights that would be difficult to obtain through direct simulation or manipulation of the MPE. In addition, it provides an accurate and efficient way to compute steady-state or transient probability distribution, avoiding the algorithmic difficulty associated with stiffness of the MPE due to large differences in sizes of rate constants. Applications of the method to several systems reveal nontrivial stochastic mechanisms of gene expression dynamics, e.g., intrinsic fluctuations can induce transient bimodality and amplify transient signals, and slow switching between promoter states can increase fluctuations in spatially heterogeneous signals. The overall approach has broad applications in modeling, analysis, and computation of complex biochemical networks with intrinsic noise.

  9. Summer student final report

    CERN Document Server

    Guzik, Jakub

    2013-01-01

    During my time spent at CERN I worked under the Technology Department of CERN, in the Machine Protection and Electrical Integrity (MPE) Group. The MPE Group supports LHC operations and maintains state of the art technology for magnet circuit protection and interlock systems for the present and future accelerators, magnet test facilities and CERN hosted experiments[1]. As a member of Magnet Powering Interlocks & Software (TE-MPE-MS) section I was involved in three different projects and used not only CERN developed tools like FESA Framework, but also open source C++ frameworks, Google Test and Google Mock. I had a chance to work with Programmable Logic Controllers and real-time devices known as Front End Computers. I was part of a software developer team, and familiarized myself with the Scrum agile software development methodology. The description and results of my work are presented in three parts of this report. Each part describes a separate project created during my participation in the CERN Summer St...

  10. Theoretical molecular structure, vibrational frequencies and NMR investigations of 2-[(1E-2-aza-2-(5-methyl(2-pyridylethenyl]-4-bromobenzen-1-ol

    Directory of Open Access Journals (Sweden)

    Cemal Parlak

    2012-08-01

    Full Text Available The normal mode frequencies and corresponding vibrational assignments, 1H and 13C NMR chemical shifts and structural parameters (bond lengths, bond and dihedral angles of 2-[(1E-2-aza-2-(5-methyl(2-pyridylethenyl]-4-bromobenzen-1-ol (2mpe-4bb Schiff base compound have been theoretically examined by means of Hartree-Fock (HF and Becke-3-Lee-Yang-Parr (B3LYP density functional methods with 6-31G(d and 6-311++G(d,p basis sets. Furthermore, reliable vibrational assignments have made on the basis of potential energy distribution (PED calculated and the thermodynamics functions, highest occupied and lowest unoccupied molecular orbitals (HOMO and LUMO of 2mpe-4bb have been predicted. Theoretical results have been successfully compared with available experimental data in the literature. Regarding the calculations, 2mpe-4bb prefers enol-imine form and DFT method is superior to HF approach except for predicting bond lengths.DOI: http://dx.doi.org/10.4314/bcse.v26i2.11

  11. A moment-convergence method for stochastic analysis of biochemical reaction networks.

    Science.gov (United States)

    Zhang, Jiajun; Nie, Qing; Zhou, Tianshou

    2016-05-21

    Traditional moment-closure methods need to assume that high-order cumulants of a probability distribution approximate to zero. However, this strong assumption is not satisfied for many biochemical reaction networks. Here, we introduce convergent moments (defined in mathematics as the coefficients in the Taylor expansion of the probability-generating function at some point) to overcome this drawback of the moment-closure methods. As such, we develop a new analysis method for stochastic chemical kinetics. This method provides an accurate approximation for the master probability equation (MPE). In particular, the connection between low-order convergent moments and rate constants can be more easily derived in terms of explicit and analytical forms, allowing insights that would be difficult to obtain through direct simulation or manipulation of the MPE. In addition, it provides an accurate and efficient way to compute steady-state or transient probability distribution, avoiding the algorithmic difficulty associated with stiffness of the MPE due to large differences in sizes of rate constants. Applications of the method to several systems reveal nontrivial stochastic mechanisms of gene expression dynamics, e.g., intrinsic fluctuations can induce transient bimodality and amplify transient signals, and slow switching between promoter states can increase fluctuations in spatially heterogeneous signals. The overall approach has broad applications in modeling, analysis, and computation of complex biochemical networks with intrinsic noise.

  12. An evaluation of fetal glucogenesis in intrauterine growth-retarded pregnancies.

    Science.gov (United States)

    Marconi, A M; Cetin, I; Davoli, E; Baggiani, A M; Fanelli, R; Fennessey, P V; Battaglia, F C; Pardi, G

    1993-07-01

    The presence of fetal glucogenesis was evaluated in nine patients with pregnancies complicated by intrauterine growth retardation (IUGR) at the time of fetal blood sampling (FBS) between 29 and 35 weeks of pregnancy. Eight were singleton pregnancies and one was a twin pregnancy in which blood samples were obtained from both twins. A maternal primed-constant infusion of D(U-13C]glucose was performed, and the presence of fetal glucogenesis was assessed by a comparison of steady-state maternal and fetal glucose enrichments. No significant difference was present between maternal and fetal molar percent excess ([MPE] P = .97), and the mean fetal to maternal (F/M) MPE ratio (0.99 +/- 0.01) was not significantly different from 1 (P = .76). F/M MPE ratio was independent of the time of FBS and umbilical venous glucose and lactate concentrations. Thus fetal glucogenesis is not demonstrable in a group of fairly severe growth-retarded fetuses after an overnight fast with this relatively noninvasive approach.

  13. Personnel requirements of medical radiation physics in radiotherapy in comparison to the current guidelines ''radiation protection in medicine''. Special consideration of intensity-modulated radiation therapy; Personalbedarf der medizinischen Strahlenphysik in der Strahlentherapie im Vergleich zur aktuellen Richtlinie ''Strahlenschutz in der Medizin''. Besondere Beruecksichtigung der intensitaetsmodulierten Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Leetz, H.K.; Eipper, H.H.; Gfirtner, H.; Schneider, P.; Welker, K.

    2014-08-15

    In 1994 and 1998 reports on staffing levels in medical radiation physics for radiation therapy were published by the ''Deutsche Gesellschaft fuer Medizinische Physik'' (DGMP, German Society for Medical Physics). Because of the technical and methodological progress, changes in recommended qualifications of staff and new governmental regulations, it was necessary to establish new staffing levels. The data were derived from a new survey in clinics. Some of the previously established results from the old reports were adapted to the new conditions by conversion. The staffing requirements were normalized to main components as in the earlier reports resulting in a simple method for calculation of staffing levels. The results were compared with the requirements in the ''Richtlinie Strahlenschutz in der Medizin'' (guidelines on radiation protection in medicine) and showed satisfactory agreement. (orig.) [German] In den Jahren 1994 und 1998 wurden von der Deutschen Gesellschaft fuer Medizinische Physik (DGMP) Berichte zum Personalbedarf der medizinischen Physik in der Strahlentherapie herausgegeben. Durch die in der Zwischenzeit erfolgte technische und methodische Weiterentwicklung auf dem Gebiet der Strahlentherapie, die Aenderungen der Qualifikationsmerkmale des Personals und die Aktualisierung der gesetzlichen Vorgaben war es notwendig, den Personalbedarf neu zu erfassen. Anhand von Umfragen in Kliniken wurden die notwendigen Daten fuer die erneute Personalbedarfsermittlung erhoben. Einige Ergebnisse aus der alten Bedarfsermittlung wurden nach Umrechnung auf die neuen Bedingungen uebernommen. Die Normierung des Personalbedarfs erfolgte, wie schon bei den frueheren Untersuchungen, auf Hauptkomponenten. Dadurch ist eine einfache Ermittlung des Personalbedarfs moeglich. Die Ergebnisse wurden mit den Vorgaben der Richtlinie Strahlenschutz in der Medizin verglichen und zeigten eine befriedigende Uebereinstimmung. (orig.)

  14. Clusters: Link between Molecules and Solids.

    Science.gov (United States)

    1987-11-01

    John Wiley and Sons, New York, 1944), pp. 254-5. 3. The material in this section was drawn from Y. Wang , T.F. George, D.M. Lindsay and A.C. Bert, J. Chem...Phys. 86, 3493 (1987); D.M. Lindsay, Y. Wang and T.F. George, J. Chem. Phys. 86, 3500 (1987). 4. E. Huckel, Z. Physik 70, 204 (1931); 72, 310 (1931...G. Rubloff Dr. Roald Hoffmann IBM Department of Chemistry Thomas J. Watson Research Center Cornell University P.O. Box 218 Ithaca, New York 14853 U

  15. Divalent Beta’ Aluminas: High Conductivity Solid Electrolytes for Divalent Cations.

    Science.gov (United States)

    1982-10-13

    Seith, Z. Phys., 57, 869 (1929) 45. G. Schwab and G. Eulitz, Z. physik. Chem., 55, 179 (1967) 6. N. Toropov, C.R. Acad. Sci. URSS , I, 147 (1935) 7. K...G. Gottfried, and J. West, Z.Kristallogr., 77, 255 (1931) 10. N.A. Toropov and N.M. Stukalova, C.R. (Dok.) Acad. Sci. URSS , 24, 459 (1939) 11. N.A...Toropov and M.M. Stukalova, C.R. (Dok.) Acad. Sci. URSS , 9 27, 974 (1940) 12. D.B. McWhan, P.D. Dernier. C. Vettier, A.S. Cooper, and’J.P. Remeika, Phys

  16. Atomphysik für Höhlenmenschen und andere Anfänger das Universum von innen : Moleküle, Atome und Elementarteilchen

    CERN Document Server

    Beetz, Jürgen

    2016-01-01

    Jürgen Beetz zeigt zuerst den Ursprung der erdachten Geschichten der Physik aus der Steinzeit, denn vieles ist so einfach, dass es schon Steinzeitmenschen hätten verstehen können. Im Anschluss daran erklärt der Autor den Aufbau von Atomen und sagt etwas zu ihren physikalischen Größen aus. Obwohl „Atom“ eigentlich „unteilbar“ bedeutet, bestehen Atome dennoch aus Teilen – dies erläutert er im Weiteren genau. Schließlich bespricht er die geheimnisvollen „Quanten“ und ihr merkwürdiges Verhalten.

  17. Optical Control of Coherent Interactions between Electron Spins in InGaAs Quantum Dots

    Science.gov (United States)

    2011-09-21

    A. Schwan,1 D. R. Yakovlev,1,3 D. Reuter,4 A. D. Wieck,4 T. L. Reinecke,2 and M. Bayer1 1Experimentelle Physik 2, Technische Universität Dortmund, D... trains orient spins normal to an external magnetic field, and particular subsets of spins precess in phase with the pulse trains . At rather low mag- netic...study here. In the present work, two subsets of spins are selected by spectrally narrow, circularly polarized laser pulse trains of different photon

  18. Das Lob der Sternkunst. Astronomie in der deutschen Aufklärung.

    Science.gov (United States)

    Baasner, R.

    Contents: 1. Einleitung. 2. Die Astronomie im Rahmen der Aufklärungs-Physik. 3. Das Lob der Sternkunst. 4. Ein Blick auf die Sternwarten. 5. Allgemeine Darstellungen der Sternkunde. 6. Schleppende Rezeption: Das kopernikanische Weltbild. 7. Himmelsphysik: Die Debatte um die causa gravitatis. 8. Theorie der Himmelskörper. 9. Die Erde als Gegenstand der Astronomie. 10. Die Sonne. 11. Der Mond. 12. Die Planeten. 13. Die Kometen. 14. Die Fixsterne. 15. Die Entstehung der Welt. 16. Beiträge der Astrotheologie. 17. Der Kampf gegen die Astrologen.

  19. Physical components of tensors

    CERN Document Server

    Altman, Wolf

    2014-01-01

    ""This book provides a clear explanation of the mathematical properties of tensors, from a physical perspective. The book is rigorous and concise, yet easy to read and very accessible. The reader will enjoy the wide variety of examples and exercises with solution, which make the book very pedagogical. I believe this can be a very useful book for anyone interested in learning about the mathematics of tensors, no matter the field of study or research. I would definitely like to have this book on my shelf, and use it as a reference in my own lectures."" -Román Orús, Institut für Physik, Jo

  20. Sitzungsberichte der Heidelberger Akademie der Wissenschaften> " Jahrgang 1990 Sitzungsber.Heidelberg 90 " "Gott hat die Natur einfältig gemacht, sie aber suchen viel Künste"

    Science.gov (United States)

    Zehe, Horst

    Der Aufsatz demonstriert anhand ausgiebig kommentierter zeitgenössischer Zeugnisse Goethes Reaktion auf die Arbeiten Fraunhofers, insbesondere auf die Entdeckung der dunklen Linien im Sonnenspektrum. Den Fehlurteilen Goethes werden dabei die Urteile zeitgenössischer Physiker wie Chladni und J.F.W. Herschel gegenübergestellt. Bislang noch ungedruckte Dokumente aus dem Weimarer Goethe- und Schiller-Archiv belegen, daß sich Goethe nicht nur literarisch mit Fraunhofer beschäftigte, sondern daß er auch dessen Versuche mit Hilfe des Jenaer Universitätsmechanikers Körner getreulich zu wiederholen suchte.

  1. Sitzungsberichte der Heidelberger Akademie der Wissenschaften¬Jahrgang 1990 Sitzungsber.Heidelberg 90¬"Gott hat die Natur einfältig gemacht, sie aber suchen viel Künste"

    Science.gov (United States)

    Zehe, Horst

    Der Aufsatz demonstriert anhand ausgiebig kommentierter zeitgenössischer Zeugnisse Goethes Reaktion auf die Arbeiten Fraunhofers, insbesondere auf die Entdeckung der dunklen Linien im Sonnenspektrum. Den Fehlurteilen Goethes werden dabei die Urteile zeitgenössischer Physiker wie Chladni und J.F.W. Herschel gegenübergestellt. Bislang noch ungedruckte Dokumente aus dem Weimarer Goethe- und Schiller-Archiv belegen, daß sich Goethe nicht nur literarisch mit Fraunhofer beschäftigte, sondern daß er auch dessen Versuche mit Hilfe des Jenaer Universitätsmechanikers Körner getreulich zu wiederholen suchte.

  2. „Überholen ohne einzuholen“ Die Entwicklung von Technologien für übermorgen in Kernenergie und Mikroelektronik der DDR

    Science.gov (United States)

    Barkleit, Gerhard

    Dem nuklearen Patt zwischen Ostblock und westlichem Staatenbündnis ist es nach weitgehend übereinstimmender Auffassung von Politik und Wissenschaft zu danken, dass der "Kalte Krieg" in der zweiten Hälfte des 20. Jahrhunderts nicht zum weltumfassenden Flächenbrand eskalierte. An der raschen Herstellung dieses Patts waren zwei Dresdner Physiker maßgeblich beteiligt, deren einer im Manhattan-Projekt in den USA gearbeitet hatte und später in England der Spionage für die Sowjetunion und des Verrats des Know-how der Atombombe überführt wurde.

  3. Lightning Technology.

    Science.gov (United States)

    1980-04-01

    33-38, 1975. 6. Schonland, B.F.J., The Lightning Discharge, Handbuch der Physik , 22, 576-628, Springer-Verlag, OHG, Berlin, 1956. 25 (K,z) R GROUND o... Dictionary of Electrical and Electronic Terms, IEEE Std 100-1977, New York, John Wiley & Sons, Inc., 1977. 313 cc C 0J 0J o -4 0$4j 4j)4J 0 1.4 >- ~ o 0 0 .,.C...Electric Power Research Institute) EL-1140, Project 1141 Final Report, Sept. 1979. 8. IEEE Standard Dictionary of Electrical and Electronics Terms, Wiley

  4. 1905 and all That%永载史册的1905年

    Institute of Scientific and Technical Information of China (English)

    John Stachel

    2005-01-01

    @@ At the end of 1904, a reader who happened to glance over the contributions to the Annalen der Physik (the premier German physics journal) of one Albert Einstein, an obscure clerk at the Swiss Patent Office, would have found just five articles-the first in 1901, when its author was 22 years old. They constituted his entire published oeuvre, and none was sufficiently distinguished for our hypothetical reader to anticipate the nature or the significance of Einstein's next five papers, [1~5] all submitted to the Annalen in 1905, his annus mirabilis or year of wonders.

  5. Prächtige Porträts erfolgreicher Forscherinnen Magnificent Portraits of Successful Researchers—An Encouragement to Young Women?

    Directory of Open Access Journals (Sweden)

    Ulrike Vogel

    2008-11-01

    Full Text Available Mit jeweils kurzen Texten und großen, illustrativen Fotos werden herausragende Forscherinnen aus Mathematik, Physik, Biologie und Medizin vorgestellt. Es werden Einblicke in die Arbeit der Wissenschaftlerinnen gegeben sowie Hinweise auf deren Wissenschaftskarriere und auch das private Umfeld. Meisterhafte Fotos und anschaulich formulierte Texte machen dieses Buch zu einem Lesevergnügen.Using short texts and large, illustrative photos respectively, the volume introduces excellent female researchers of mathematics, physics, biology, and medicine. They give insight into the work of female scientists as well as references to their scientific career and their private surroundings. Expert photos and descriptively formulated texts make this book a joy to read.

  6. Energy and Chemical Change

    Science.gov (United States)

    1993-01-01

    Heisenberg, 1925; Bo,’n and Jordan , 1925; Dirac, 1925; Born, Heisenberg and Jordan , 1926. 2. It was only in the 1930’s that Lie algebras were being used...Heisenberg, W. and Jordan , P. (1926), Zur Quantenmechanik. II, Z. Physik 35, 556. Born, M. and Jordan , P. (1925), Zur Quantenmechanik, Z. Phy ik 34...Farantos, S.C., Huxley , P. and Varandas, A.J.C. (1984), Molecu lar Potential Energy Func ions, Wiley, Chiches:.r. Nesbitt, D.. (1988), High-Resolution

  7. Kosmologie für Höhlenmenschen und andere Anfänger das Universum von aussen : Trabanten, Planeten, Sterne, Galaxien

    CERN Document Server

    Beetz, Jürgen

    2016-01-01

    Jürgen Beetz zeigt zuerst den Ursprung der erdachten Geschichten der Physik aus der Steinzeit, denn vieles ist so einfach, dass es schon Steinzeitmenschen hätten verstehen können. Im Anschluss daran untersucht der Autor das Weltall auf seine Bestandteile: Monde, Planeten, Sterne, Galaxien usw. Daraus ergibt sich die Frage nach dessen Struktur und Dynamik: Ist das Universum ewig, endlos, konstant? Nichts davon: Es hat eine Entstehungsgeschichte, es expandiert und verändert sich – zum Teil aus noch ungeklärten Ursachen. Besonderes Augenmerk richtet er auf die Expansion des Weltalls und die sich daraus ergebenden Folgen.

  8. Emotionales Erleben von Lehrkräften beim Unterrichten

    OpenAIRE

    Frenzel, Anne C.; Götz, Thomas

    2007-01-01

    Ziel dieser Studie war es, das Ausmaß an Variabilität des Erlebens von Freude, Angst und Ärger bei Lehrkräften zu ermitteln, das auf ihre Persönlichkeit, das Unterrichtsfach (hier: Mathematik vs. Physik) und die jeweils unterrichtete Klasse zurückzuführen ist. Zudem wurde der Einfluss von Person- und Kontextmerkmalen auf das emotionale Erleben beim Unterrichten untersucht. 59 Gymnasiallehrkräfte (9 weiblich) gaben anhand von einem Fragebogen sowie einem Tagebuch Auskunft über ihre Unterrichts...

  9. Team anderthalb : Wirkungsgrad

    OpenAIRE

    2000-01-01

    Die Fakultät für Physik und Astronomie produziert in regelmäßiger Folge für das Universitätsmagazin CAMPUS TV Filme über physikalische Phänomene. Die Länge der Filme ist auf jeweils 90 Sekunden (oder anderthalb Minuten) beschränkt, woraus sich der Titel der Serie 'Team anderthalb' ergibt. In dieser Folge wird der „Wirkungsgrad“ behandelt. Eine Dampfmaschinen wandelt die Wärmeenergie von heißen Dampf in Bewegung um. Nur wie erfolgreich ist sie dabei? Der Wirkungsgrad gibt Auskunft. Die Einsch...

  10. Einstein's Approach to Statistical Mechanics: The 1902-04 Papers

    Science.gov (United States)

    Peliti, Luca; Rechtman, Raúl

    2016-09-01

    We summarize the papers published by Einstein in the Annalen der Physik in the years 1902-1904 on the derivation of the properties of thermal equilibrium on the basis of the mechanical equations of motion and of the calculus of probabilities. We point out the line of thought that led Einstein to an especially economical foundation of the discipline, and to focus on fluctuations of the energy as a possible tool for establishing the validity of this foundation. We also sketch a comparison of Einstein's approach with that of Gibbs, suggesting that although they obtained similar results, they had different motivations and interpreted them in very different ways.

  11. Einleitung

    Science.gov (United States)

    Walther-Klaus, Ellen

    Deutschland hat sich in den letzten Jahrzehnten den internationalen Ruf erworben, auf dem Gebiet der Technologie führend zu sein. Große, weitreichende Erfindungen sind in Deutschland gemacht worden. Viele Nobelpreise gehen nach Deutschland: Robert Bosch, Nikolaus Otto und Konrad Zuse gehören genauso zu den großen Erfindern, wie Melitta Bentz und Emmy Noether. 85 % aller Nobelpreise, die seit 1901 nach Deutschland gingen, sind in den Kategorien Chemie, Physik und Medizin vergeben worden. Allein im Jahr 2007 wurden in Deutschland fast 50.000 Patente angemeldet.

  12. Nanophysik: Wärmeübertrag auf der Nanometerskala

    Science.gov (United States)

    Kittel, Achim

    2006-01-01

    Gegen Ende des 19. Jahrhunderts waren die grundlegenden Prozesse des Wärmeaustauschs verstanden. Die Gesetze dienten dann als Grundlage für die Quantenmechanik. Doch gelten diese Gesetze auch auf der Nanometerskala? In den 1970er-Jahren wurde eine Theorie für den Wärmeübertrag im atomaren Bereich entwickelt. Physiker der Universität Oldenburg überprüften deren Vorhersagen und stießen dabei auf signifikante Abweichungen, welche auf einen Zusammenbruch der klassischen, makroskopischen Elektrodynamik hindeuten.

  13. Leologisch! Alltagsrätsel einfach erklärt

    CERN Document Server

    Ludick, Leo

    2013-01-01

    Wie entsteht ein Regenbogen? Warum ist der Himmel blau? Was sind Lichtjahre? Wie ist das mit den Jahreszeiten? Was sind Schwarze Löcher? Lauter Fragen, die Klein und Groß immer wieder beschäftigen. Der Physiker Leo Ludick hat im Lauf der Zeit solche Fragen gesammelt und in seiner Kolumne "Alltagsrätsel" in der Tageszeitung "Oberösterreichische Nachrichten" wöchentlich prägnante und einleuchtende Antworten darauf gegeben. Dieses Büchlein fasst nun diese Erklärungen thematisch sortiert zusammen. Einfach leologisch!

  14. Diode Laser Pumped Alkali Vapor Lasers with Exciplex-Assisted Absorption

    Science.gov (United States)

    2013-05-14

    Torr of Helium in the discharge is similar to the DPAL systems, o 13 = 7.2 x 10’ 13 cm2. The state degeneracy’s of, g3 =7, g2 =3 and g1 = 5 are more...krypton and helium was used . These gases were further purified by passage through molecular sieve traps that were immersed in liquid nitrogen. The total...was produced from a dye laser pumped by the 308 nm output of an excimer laser running at 10 Hz (Lambda Physik EMG201/FL3002). The linewidth was

  15. Observation of Magnetic Fields in Laser-Produced Plasma Using the Zeeman Effect.

    Science.gov (United States)

    1983-09-30

    Back 9 effect ), Irons, McWhirter and Peacock ° did extensive spectroscopic investigations of the C+4 ions pro- duced by the laser irradiation of...8. N.J. Peacock and B.A. Norton, Phys. Rev. A 11, 2142 (1975). 9. F. Paschen and E. Back , Ann. Physik 39, 897 (1912); 40, 960 (1913). 10. F.E. Irons...ZEEMAN EFFECT 6. PERFORMING ORG. REPORT NUMBER 7. AUTI4OR(e) 11. CONTRACT OR GRANT NUMER(a) E. A. McLean, J. A. Stamper, C. K. Manka,* H. R. Griem,** D. W

  16. IEEE Conference Record of 1982 Fifteenth Power Modulator Symposium, 14-16 June 1982.

    Science.gov (United States)

    1982-01-01

    early time of the Gas Discharges," Institut fuer Plasma Physik, discharge is insufficient or does not contribute to Garching bei Muenchen, December 1969...34 Max Planck Inst. fur Plasmaphysik Garching , bei Munchen IFP? 4/72 (Dec, 1969) 88 Blow,. - AD-A119 664 PALISADES INST FOR RESEARCH SERVICES INC NEW...uncontrolled emission of uv radiation MJVDPLAMEa DCC -.- 4IiI K lss Iv:, :t Ilog: SOURCE UY RA --’hOO P1"_ the voltage across a matched 1 .Q Fig. 7

  17. Quod racio princifantis et subiecti sumitur ex ragione actus et potencie

    OpenAIRE

    Flùeler, Christoph

    1994-01-01

    pp. 127-141 Die erste Phase der Rezeption der aristeteUschen PeUtica ist deutUch gepràgt von einem ausgesprechenen Hang, MedeUe der aristeteUschen Logik, Physik und Metaphysik, in die pelitische PhUesophie zu impertieren. Anhand von zwei Beispielen, mòchte ich im felgenden zeigen, wie Begriffe, die Aristótéles in der Metaphysik behandelt, im spàten Mittelalter auf die poUtische Wissenschaft angewendet wurden. Es ist dies die Theerie der Beziehung (relatie) und das Verhàlt...

  18. Leaf level VOC emissions of single plants from Amazonian and Mediterranean ecosystems: Ontogeny and flooding as stress factor for VOC emissions

    OpenAIRE

    Bracho Nunez, Araceli

    2010-01-01

    Die Vegetation ist die wichtigste Quelle von organischen flüchtigen Verbindungen (auf Englisch volatile organic compounds,VOCs), die einen bemerkenswerten Einfluss auf der Chemie und Physik der Atmosphäre haben. VOCs beeinflussen die oxidative Kapazität der Atmosphäre und tragen zu der Bildung und zum Wachstum von sekundären organischen Aerosolen bei, welche einerseits eine Streuung und Reflektierung der Energie verursachen und andererseits sich an der Bildung und Entwicklung von Wolken betei...

  19. Einstein's Approach to Statistical Mechanics: The 1902-04 Papers

    CERN Document Server

    Peliti, Luca

    2016-01-01

    We summarize the papers published by Einstein in the Annalen der Physik in the years 1902-04 on the derivation of the properties of thermal equilibrium on the basis of the mechanical equations of motion and of the calculus of probabilities. We point out the line of thought that led Einstein to an especially economical foundation of the discipline, and to focus on fluctuations of the energy as a possible tool for establishing the validity of this foundation. We also sketch a comparison of Einstein's approach with that of Gibbs, suggesting that although they obtained similar results, they had different motivations and interpreted them in very different ways.

  20. Testing Supersymmetry #13TeV

    CERN Multimedia

    2015-01-01

    Follow British @ATLASexperiment physicist Mike Flowerdew from Max-Planck-Institut für Physik (Werner-Heisenberg-Institut), Germany, as he shares his thoughts about the new physics frontiers opening up now that the LHC has collisions at the higher energy of #13TeV. Each week a new video will be uploaded to https://www.youtube.com/playlist?list... allowing you to follow physicists from @ATLASexperiment @ALICEexperiment @CMSexperiment or @LHCbExperiment as they search the new frontiers in physics. Read more about these new frontiers in physics: http://cern.ch/go/x8VH

  1. On the nature of the change in the wave function in a measurement in quantum mechanics

    CERN Document Server

    Snyder, D M

    1996-01-01

    Generally a central role has been assigned to an unavoidable physical interaction between the measuring instrument and the physical entity measured in the change in the wave function that often occurs in measurement in quantum mechanics. A survey of textbooks on quantum mechanics by authors such as Dicke and Witke (1960), Eisberg and Resnick (1985), Gasiorowicz (1974), Goswami (1992), ift fur Physik, vol. 158, p. 417), supports these points. Work on electron shelving is reported by Dehmelt and his colleagues (Physical Review Letters, vol. 56, p. 2797), Wineland and his colleagues (Physical Review Letters, vol. 57, p. 1699), and Sauter, Neuhauser, Blatt, and Toschek (Physical Review Letters, vol. 57, p. 1696).

  2. Wie aus dem Nichts etwas entsteht Gespräche über Antimaterie

    CERN Document Server

    AUTHOR|(CDS)2051122

    2017-01-01

    Antimaterie beschäftigt nicht nur Physiker, sondern auch die Phantasie von Science fiction-Autoren, Star Trek-Fans und Laien. Aber was ist eigentlich Antimaterie, und wie stellt man sie her? Kann man sie speichern? Wird sie bald eine Rolle im Alltag spielen? Und warum verdanken wir unsere Existenz – und die unseres Universums – einem winzigen Unterschied zwischen Materie und Antimaterie? Rolf Landua, einer der weltweit führenden Experten auf diesem Gebiet, beantwortet in seinem neuen Buch anschaulich diese und andere Fragen.

  3. Seismic Interface Waves in Coastal Waters: A Review

    Science.gov (United States)

    1980-11-15

    water. In 1976 McLeroy and his co-workers [1861 again performed a very extensive real-world experiment in the Gulf of Mexico . Using a receiving array of...York, Academic Press, 1967. 4. SOMMERFELD, A. Uber die Ausbreitung der Wellen in der drahtlosen Telegraphie. Annalen der Physik, 28, 1909. 665-736. 5...Rayleigh waves on the confines of two solid elastic media. Doklady Akademii Nauk, SSSR, 33, 1947: 15-17. 30. KOPPE, H. Uber Rayleigh-Wellen an der

  4. Clinical Value of Tumor Markers for Determining Cause of Pleural Effusion

    Institute of Scientific and Technical Information of China (English)

    Yan Gu; Kan Zhai; Huan-Zhong Shi

    2016-01-01

    Background: It is often challenging to distinguish tuberculous pleural effusion (TPE) from malignant pleural effusion (MPE);thoracoscopy is among the techniques with the highest diagnostic ability in this regard.However, such invasive examinations cannot be performed on the elderly, or on those in poor physical condition.The aim of this study was to explore the differential diagnostic value of carbohydrate antigen 125 (CA 125), carbohydrate antigen 199 (CA 199), carcinoembryonic antigen (CEA), neuron-specific enolase (NS E), and squamous cell carcinoma (SCC) associated antigen in patients with TPE and MPE.Methods: Using electrochemiluminescence, we measured the concentration of tumor markers (TMs) in the pleural effusion and serum of patients with TPE (n =35) and MPE (n =95).We used receiver operating characteristic (ROC) curve analysis to evaluate the TMs and differentiate between TPE and MPE.Results: The cut-offvalues for each TM in serum were: CA125, 151.55 U/ml;CA199, 9.88 U/ml;CEA, 3.50 ng/ml;NSE, 13.27 ng/ml;and SCC, 0.85 ng/ml.Those in pleural fluid were: CA125, 644.30 U/ml;CA199, 12.08 U/ml;CEA, 3.35 ng/ml;NSE, 9.71 ng/ml;and SCC, 1.35 ng/ml.The cut-offvalues for the ratio ofpleural fluid concentration to serum concentration (P/S ratio) of each TM were: CA125, 5.93;CA199, 0.80;CEA, 1.47;NSE, 0.76;and SCC, 0.90.The P/S ratio showed the highest specificity in the case of CEA (97.14%).ROC curve analysis revealed that, for all TMs, the area under the curve in pleural fluid (0.95) was significantly different from that in serum (0.85;P < 0.001).Conclusions: TMs in TPE differ significantly from those in MPE, especially when detected in pleural fluid.The combined detection of TMs can improve diagnostic sensitivity.

  5. Prolonged Drainage and Intrapericardial Bleomycin Administration for Cardiac Tamponade Secondary to Cancer-Related Pericardial Effusion.

    Science.gov (United States)

    Numico, Gianmauro; Cristofano, Antonella; Occelli, Marcella; Sicuro, Marco; Mozzicafreddo, Alessandro; Fea, Elena; Colantonio, Ida; Merlano, Marco; Piovano, Pierluigi; Silvestris, Nicola

    2016-04-01

    Malignant pericardial effusion (MPE) is a serious complication of several cancers. The most commonly involved solid tumors are lung and breast cancer. MPE can give rise to the clinical picture of cardiac tamponade, a life threatening condition that needs immediate drainage. While simple pericardiocentesis allows resolution of the symptoms, MPE frequently relapses unless further procedures are performed. Prolonged drainage, talcage with antineoplastic agents, or surgical creation of a pleuro-pericardial window are the most commonly suggested ones. They all result in MPE resolution and high rates of long-term control. Patients suitable for further systemic treatments can have a good prognosis irrespective of the pericardial site of disease. We prospectively enrolled patients with cardiac tamponade treated with prolonged drainage associated with Bleomycin administration. Twenty-two consecutive patients with MPE and associated signs of hemodynamical compromise underwent prolonged drainage and subsequent Bleomycin administration. After injection of 100 mg lidocaine hydrochloride, 10 mg Bleomycin was injected into the pericardial space. The catheter was clumped for 48 h and then reopened. Removal was performed when the drainage volume was <25 mL daily. Twelve patients (54%) achieved complete response and 9 (41%) a partial response. Only 1 (5%) had a treatment failure and underwent a successful surgical procedure. Acute toxicity was of a low degree and occurred in 7 patients (32%). It consisted mainly in thoracic pain and supraventricular arrhythmia. The 1-year pericardial effusion progression-free survival rate was 74.0% (95% confidence interval [CI]: 51.0-97.3). At a median follow-up of 75 months, a pericardial progression was detected in 4 patients (18%). One- and two-year overall survival rates were 33.9% (95% CI: 13.6-54.2) and 14.5% (95% CI: 0.0-29.5), respectively, with lung cancer patients having a shorter survival than breast cancer patients. The worst

  6. A PARTICIPAÃÃO NA LISTA DE EMPRESAS COM MELHORES PRÃTICAS PARA COM OS FUNCIONÃRIOS E SEU IMPACTO NA PERFORMANCE: UM ESTUDO EMPÃRICO SOB A LÃGICA DA RBV (RESOURCE-BASED VIEW

    Directory of Open Access Journals (Sweden)

    Ludwig Miguel Agurto Berdejo

    2009-09-01

    Full Text Available Neste trabalho empírico, procuram-se evidências do impacto na performance das empresas decorrente da participação da organização na lista de empresas com melhores práticas para com os seus empregados (MPE. O trabalho sustenta-se no construto da resource-based view (RBV da empresa, estruturado em Barney (1991, entendendo a presença da empresa nas listagens de MPE como um recurso idiossincrático e difícil de ser imitado, o que leva a considerar este recurso como uma fonte de vantagem competitiva sustentável. O objetivo deste trabalho é verificar se a presença constante na lista de MPE no período de 2004 a 2006 proporciona uma performance financeira, medida pelo ROA e ROE, e de mercado, medida pelo Q de Tobin, superior em relação a um grupo de empresas comparáveis incluídas dentro de um grupo de controle. O período completo da análise compreende de 2001 a 2006, tendo sido testados 26 pares de empresas. Usando o Teste Wilcoxon, observouse que, para o ano de 2006, as amostras apresentam uma diferença significativa ao nível de 5% para o ROA e de 3% para o ROE evidenciando um melhor desempenho das empresas pertencentes à lista de MPE. Adicionalmente, usando a técnica de dados em painel, observou-se que a variável que denota a quantidade de participações que a empresa possui na listagem das MPE para o período de 2001 a 2006 apresenta significância para um nível menor do que 10%, contribuindo para o modelo do valor da empresa medido pelo Q de Tobin. Desta forma, este trabalho traz evidências que contribuem para demonstrar que a performance foi positivamente impactada pela sustentação de capacidades intangíveis e socialmente complexas. Com a sustentação destas capacidades podendo dificultar a sua imitação por concorrentes atuais e futuros.

  7. Depth-area-duration characteristics of storm rainfall in Texas using Multi-Sensor Precipitation Estimates

    Science.gov (United States)

    McEnery, J. A.; Jitkajornwanich, K.

    2012-12-01

    This presentation will describe the methodology and overall system development by which a benchmark dataset of precipitation information has been used to characterize the depth-area-duration relations in heavy rain storms occurring over regions of Texas. Over the past two years project investigators along with the National Weather Service (NWS) West Gulf River Forecast Center (WGRFC) have developed and operated a gateway data system to ingest, store, and disseminate NWS multi-sensor precipitation estimates (MPE). As a pilot project of the Integrated Water Resources Science and Services (IWRSS) initiative, this testbed uses a Standard Query Language (SQL) server to maintain a full archive of current and historic MPE values within the WGRFC service area. These time series values are made available for public access as web services in the standard WaterML format. Having this volume of information maintained in a comprehensive database now allows the use of relational analysis capabilities within SQL to leverage these multi-sensor precipitation values and produce a valuable derivative product. The area of focus for this study is North Texas and will utilize values that originated from the West Gulf River Forecast Center (WGRFC); one of three River Forecast Centers currently represented in the holdings of this data system. Over the past two decades, NEXRAD radar has dramatically improved the ability to record rainfall. The resulting hourly MPE values, distributed over an approximate 4 km by 4 km grid, are considered by the NWS to be the "best estimate" of rainfall. The data server provides an accepted standard interface for internet access to the largest time-series dataset of NEXRAD based MPE values ever assembled. An automated script has been written to search and extract storms over the 18 year period of record from the contents of this massive historical precipitation database. Not only can it extract site-specific storms, but also duration-specific storms and

  8. Circulating angiogenic factors are related to the severity of gestational hypertension and preeclampsia, and their adverse outcomes

    Science.gov (United States)

    Leaños-Miranda, Alfredo; Méndez-Aguilar, Francisco; Ramírez-Valenzuela, Karla Leticia; Serrano-Rodríguez, Marilyn; Berumen-Lechuga, Guadalupe; Molina-Pérez, Carlos José; Isordia-Salas, Irma; Campos-Galicia, Inova

    2017-01-01

    Abstract Gestational hypertension (GH) and preeclampsia (PE) are characterized by an imbalance in angiogenic factors. However, the relationship among these factors with the severity of hypertensive disorders of pregnancy (HDP) and adverse outcomes are not fully elucidated. We examined whether these biomarkers are related with the severity of HDP and adverse outcomes. Using a cross-sectional design, serum concentrations of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and soluble endoglin were determined in 764 pregnant women: 75 healthy pregnant, 83 with mild GH (mGH), 105 with severe GH (sGH), 122 with mild PE (mPE), and 379 with severe PE (sPE). All angiogenic factors’ concentrations were significantly different (P ≤ 0.041) in HDP than in healthy pregnancy. In addition, these factors were markedly different in sPE than in mPE, sGH, or mGH (P ≤ 0.027) and in patients with sGH that in those with mPE or mGH (P < 0.05). As compared to mGH and mPE, patients with sGH and sPE had higher rates of both preterm delivery at <34 weeks of gestation and small-for-gestational age infants. Moreover, patients with sPE had higher rates of adverse maternal outcomes (P < 0.001) when compared to patients with mGH, sGH, or mPE. In all cases, levels of sFlt-1/PlGF ratio were significantly higher in patients with sGH and sPE who had adverse perinatal and maternal outcomes than in those with sGH and sPE who did not (P ≤ 0.016). Circulating concentrations of angiogenic factors appear to be suitable markers to assess the severity of GH and PE, and adverse outcomes. PMID:28121958

  9. Highly sensitive quantification of unconjugated 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol in a cannabis user's hair using micropulverized extraction.

    Science.gov (United States)

    Kuwayama, Kenji; Miyaguchi, Hajime; Yamamuro, Tadashi; Tsujikawa, Kenji; Kanamori, Tatsuyuki; Iwata, Yuko T; Inoue, Hiroyuki

    2016-05-01

    We previously developed a simple and highly sensitive analytical method for 11-nor-9-carboxy-Δ(9)-tetrahydrocannabinol (THC-COOH) in spiked hair using micropulverized extraction (MPE) and liquid chromatography/tandem mass spectrometry (LC/MS/MS). Using this method, we were able to quantify THC-COOH at 0.2pg/mg, which is the cut-off level recommended by the Society of Hair Testing. However, it was impossible to prove the validity of the method and the presence of THC-COOH conjugated with glucuronide in hair because we did not have authentic hair containing THC-COOH at the cut-off levels at that time. In this study, the previously developed method was verified using recently obtained hair from a cannabis user. The concentrations of THC-COOH quantified using the method were 0.36±0.01pg/mg without hydrolyzation for glucuronide and 0.49±0.05pg/mg with hydrolyzation after MPE, whereas the concentration quantified using the conventional alkaline dissolution and gas chromatography/tandem mass spectrometry with negative ion chemical ionization was 0.50±0.02pg/mg. The results proved that THC-COOH could be extracted completely from authentic hair containing THC-COOH at the recommended cut-off level using MPE. In addition, MPE with and without hydrolyzation, unlike alkaline dissolution of hair, enabled the measurement of the percentage of the conjugate form in total THC-COOH. The percentage of conjugated THC-COOH in hair measured using the MPE was approximately 26%, which was greatly different from previously reported data (>75%). The discrimination between conjugated and unconjugated compounds in hair is important to understand the mechanism of drug uptakes into hair. More data obtained with our simple and highly sensitive method from the hair of cannabis users would help to understand the relationship of concentrations between THC-COOH and its conjugate in hair.

  10. 液相化学处理MBBR填料对城市污水厂尾水深度脱氮的影响%Influence of the Liquid-phase Chemical Method Modified MBBR Carriers on Advanced Nitrogen Removal of Urban Wastewater Treatment Plant Effluent

    Institute of Scientific and Technical Information of China (English)

    李春梅; 王海燕; 王有乐; 杭前宇; 程子芮; 刘凯

    2016-01-01

    To improve the nitrate removal ability of the polythene ( PE) carriers in the moving bed biofilm reactors ( MBBR) , the liquid-phase chemical method was used to modify the PE carriers and the ability of advanced nitrogen removal denitrification of the modified PE ( MPE) carriers also studied extensively. The results showed that the static contact angle of the MPE surface was 75. 5° which decreased by 26. 6% compared with that of PE. The MPE surface structure roughness was higher than that of PE through the scanning electron microscopy ( SEM ) observation, and the oxygen element content of MPE was increased and the surface structure was changed compared with PE using the energy dispersive spectra and IR spectra analysis. The denitrification ability of MPE MBBR was improved obviously compared with PE MBBR. When the influent NO3--N and TN of MPE MBBR were (8. 5 ± 1. 5) mg∕L and (14. 3 ± 2. 1) mg∕L, the NO3--N and TN removal were (75. 2 ± 7. 0)% and (56. 5 ± 10. 7)%, respectively, which were increased 20. 8% and 58. 1% compared with the PE MBBR accordingly.%为进一步提高移动床生物膜反应器( MBBR)中普通聚乙烯( PE)填料对城市污水处理厂尾水中NO3--N的去除能力,采用液相化学处理法对PE进行改性,并对其反硝化深度脱氮效能进行研究。结果表明:改性聚乙烯( MPE)填料的静态接触角为75.5°,与PE相比降低了26.6%;扫描电镜显示,MPE与PE相比表面结构粗糙度增强;能谱及红外光谱分析表明,MPE表面氧元素含量及结构都发生了变化;MPE填料的MBBR反硝化能力与PE相比得到了明显提高,当进水NO3--N和TN浓度分别为(8.5±1.5)和(14.3±2.1) mg∕L时,MPE填料的MBBR对NO3--N和TN的平均去除率分别为(75.2±7.0)%和(56.5±10.7)%,与PE相比分别提高了20.8%和58.1%。

  11. Non-standard coupled extensional and bending bias tests for planar pantographic lattices. Part II: comparison with experimental evidence

    Science.gov (United States)

    Turco, Emilio; Barcz, Katarzyna; Rizzi, Nicola Luigi

    2016-10-01

    In dell'Isola et al. (Zeitschrift für Angewandte Math und Physik 66(6):3473-3498, 2015, Proc R Soc Lond A Math Phys Eng Sci 472(2185):1-23, 2016) pantographic sheets are proposed as a basic constituent for a novel metamaterial. In Part I, see Turco et al. (Zeitschrift für Angewandte Math und Physik, doi: 10.1007/s00033-016-0713-4, 2016), two different numerical models are applied in order to design an experimental setup aimed to prove the effectiveness of introduced concept. The aim of this paper is to prove that the Hencky-type model introduced for planar pantographic sheets allows for the correct prediction, in a large range of imposed displacements, of the experimental measurements concerning specimens undergoing coupled bending and extensional deformations. The four-parameter numerical model introduced is shown to have a large range of applicability: Indeed without changing the values of the material parameters previously attributed in simple extensional tests to a specific specimen by a best-fit procedure, it is possible to forecast its behavior in all the considered type of imposed deformations. The measurements performed include the determination of reactive forces exerted by used hard devices, and the numerical modeling is able to predict very carefully quantitatively and qualitatively also this complex aspect of phenomenology, where previously attempted models seem to have failed.

  12. Non-standard coupled extensional and bending bias tests for planar pantographic lattices. Part I: numerical simulations

    Science.gov (United States)

    Turco, Emilio; Barcz, Katarzyna; Pawlikowski, Marek; Rizzi, Nicola Luigi

    2016-10-01

    In dell'Isola et al. (Zeitschrift für Angewandte Math und Physik 66(6):3473-3498, 2015, Proc R Soc Lond A Math Phys Eng Sci 472(2185), 2016), the concept of pantographic sheet is proposed. The aim is to design a metamaterial showing: (i) a large range of elastic response; (ii) an extreme toughness in extensional deformation; (iii) a convenient ratio between toughness and weight. However, these required properties must coexist with non-detrimental mechanical characteristics in the presence of other kinds of imposed displacements. The aim of this paper is to prove via numerical simulations that pantographic sheets may effectively resist to coupled bending and extensional deformations. The four-parameter model introduced shows its versatility as it is able to encompass all the considered types of (large) deformations. The numerical integration scheme which we use is based on the same concepts exploited in Turco et al. (Zeitschrift für Angewandte Math und Physik 67(4):1-28, 2016): They prove that the Hencky-type discretization is very efficient also in nonlinear large deformations and large displacements regimes. In Part II of this paper, we will show that the used models are very effective to describe experimental evidence.

  13. Relativitätstheorie ein Sachcomic

    CERN Document Server

    Bassett, Bruce

    2012-01-01

    E = mc² – so einfach ist eine Revolution! Nichts ist schneller als Licht! Wie lange noch? Was fangen wir mit einer vierten Dimension an und mit krummen Räumen? Einstein gilt als größter Physiker der Neuzeit, das amerikanische Magazin „Time“ machte ihn sogar zum Mann des Jahrhunderts. Einstein ist das Lieblingsgenie vieler Menschen: ein Radikaler im wissenschaftlichen Arbeiten und engagierter sozialistischer Pazifist. Es ist nun gut hundert Jahre her, seit Einsteins Relativitätstheorie unseren Blick auf Raum, Zeit und Materie revolutionierte. Einsteins Gedankenexperimente sind berüchtigt für ihre Komplexität, aber sie bieten fesselnde Beschreibungen der Grundlagen, auf denen die Welt funktioniert. Relativitätstheorie und Quantentheorie sind die zwei Hauptsäulen der modernen Physik. Dieser Sachcomic nimmt Sie mit auf eine unterhaltsame Bildungsreise durch Raum und Zeit vorbei an Schwarzen Löchern und quer durch Gravitationsfelder (Je schneller Sie lesen, desto jünger werden Sie!!). Sie werden ...

  14. A hybrid evolutionary data driven model for river water quality early warning.

    Science.gov (United States)

    Burchard-Levine, Alejandra; Liu, Shuming; Vince, Francois; Li, Mingming; Ostfeld, Avi

    2014-10-01

    China's fast pace industrialization and growing population has led to several accidental surface water pollution events in the last decades. The government of China, after the 2005 Songhua River incident, has pushed for the development of early warning systems (EWS) for drinking water source protection. However, there are still many weaknesses in EWS in China such as the lack of pollution monitoring and advanced water quality prediction models. The application of Data Driven Models (DDM) such as Artificial Neural Networks (ANN) has acquired recent attention as an alternative to physical models. For a case study in a south industrial city in China, a DDM based on genetic algorithm (GA) and ANN was tested to increase the response time of the city's EWS. The GA-ANN model was used to predict NH3-N, CODmn and TOC variables at station B 2 h ahead of time while showing the most sensitive input variables available at station A, 12 km upstream. For NH3-N, the most sensitive input variables were TOC, CODmn, TP, NH3-N and Turbidity with model performance giving a mean square error (MSE) of 0.0033, mean percent error (MPE) of 6% and regression (R) of 92%. For COD, the most sensitive input variables were Turbidity and CODmn with model performance giving a MSE of 0.201, MPE of 5% and R of 0.87. For TOC, the most sensitive input variables were Turbidity and CODmn with model performance giving a MSE of 0.101, MPE of 2% and R of 0.94. In addition, the GA-ANN model performed better for 8 h ahead of time. For future studies, the use of a GA-ANN modelling technique can be very useful for water quality prediction in Chinese monitoring stations which already measure and have immediately available water quality data.

  15. Interpreting aerosol lidar profiles to better estimate surface PM2.5 for columnar AOD measurements

    Science.gov (United States)

    Chu, D. Allen; Tsai, Tzu-Chin; Chen, Jen-Ping; Chang, Shuenn-Chin; Jeng, Yung-Jyh; Chiang, Wei-Li; Lin, Neng-Hui

    2013-11-01

    Satellite aerosol optical depth (AOD) products have been used to estimate surface PM2.5 in different parts of the world. However, some revealed good but some relatively poorer relationship between AOD and PM2.5. The increasingly available lidar-based aerosol extinction profiles provide insights into the boundary layer as well as residual above it. Here we report a study in Taiwan using four-year (2006-2009) MPLNet data to characterize aerosol vertical distribution. We derived haze layer height (HLH) from MPLNet aerosol extinction profiles and classified profile differences by mean PBL extinction (MPE) and near-surface extinction (NSE). The former represents the mean extinction within boundary layer and the latter the closest extinction to surface. The comparison of MPE versus NSE leads to three distinct classifications of aerosol profiles to help interpret the relationship between AOD and PM2.5. The approximation of normalizing AODAERONET by HLH closely follows MPE in correlating with PM2.5 (≥0.8 with respect to season or ≥0.85 with respect to profile classification). The correlation resulted from AODMODIS/HLH is systematically lower than that derived by AODAERONET/HLH. PM2.5 values are overall better estimated by profile classification than those derived by season. Better performance of PM2.5 is obtained with the approximation (i.e., normalizing AOD by HLH) than that using AOD only. The performance metrics used in quantifying the relationship reveal improvements in uncertainty by 2.9 μg m-3 (or 20%) with AODAERONET/HLH and 2.3 μg m-3 (or 15%) with AODMODIS/HLH in comparison to using AOD only.

  16. IP over DVB-S2的数据封装研究%Research on encapsulation analysis of IP over DVB-S2

    Institute of Scientific and Technical Information of China (English)

    栗彪; 黄焱; 张白愚

    2014-01-01

    This paper analyses the transmission of IP over DVB-S2, and gives a particular discussion on the available encapsulation protocols for DVB-S2. Multi-protocol encapsulation (MPE), unidirectional lightweight encapsulation (ULE) and generic stream encapsulation (GSE) are the available encapsulation protocols for DVB-S2. Then combining with the IP datagram of the real satellite traffic, the encapsulation efficiency and performance of the available encapsulation protocols are compared. The tests demonstrate that GSE and ULE are more efficient than MPE. GSE is more flexible than others. The IP encapsulation analysis of DVB-S2 provides important references for the IP transmission design of the future DVB systems.%对 DVB-S2中 IP 数据的传输进行了分析,详细讨论了多协议封装,单向轻量封装以及普通流封装各自的封装过程,并结合 DVB-S2系统实际网络环境中的 IP 数据,比较了这3种封装协议的封装性能。理论分析和实验结果表明, GSE、ULE 的封装效率较 MPE 更高效, GSE 封装更灵活,扩展性更好,为下一代及未来 DVB 标准中 IP 封装协议的选择和优化提供了参考和依据。

  17. Mediastinoscope-controlled parasternal fenestration of the pericardium: definitive surgical palliation of malignant pericardial effusion

    Directory of Open Access Journals (Sweden)

    Toth Imre

    2012-06-01

    Full Text Available Abstract Background The tumorous infiltration or carcinosis of the pericardium could cause pericardial effusion in up to one-third of cases of malignancy, thus potentially interfere with the otherwise desirable oncological treatment. The existing surgical methods for the management of pericardial fluid are well-established but are not without limitations in the symptomatic relief of malignant pericardial effusion (MPE. The recurrence rate ranges between 43 and 69% after pericardiocentesis and 9 to 16% after pericardial drainage. The desire to overcome relative limitations of the existing methods led us to explore an alternative approach. Methods The standard armamentarium of the Carlens collar mediastinoscopy procedure was utilized in a Chamberlain parasternal approach of the pericardial sac. The laterality of approach was decided based upon the pleural involvement, as tumor-free pericardiopleural reflection is required. A pericardio-pleural window at least 3 cm in diameter was created. From January 2000 to December 2009, 22 cases were operated on with mediastinoscope-controlled parasternal fenestration (MCPF. Considering the type of the primary tumor, there were 11 lung cancer, 6 breast cancers, 2 haematologic malignancies and in 3 patients the origin of malignancy could not be verified. Results There were no operative deaths. We lost one patient (4.5% in the postoperative hospital period. All of the surviving patients had a minimum of 2 months of symptom-free survival. We detected transient recurrence of MPE in one patient (4.5% 14 days after the MCPF, which disappeared spontaneously after 24 hours. Conclusion The MCPF offers a real alternative in certain cases of pericardial effusion. We recommend this method especially for the definitive surgical palliation of MPE.

  18. Immune-modulating effects of bevacizumab in metastatic non-small-cell lung cancer patients

    Science.gov (United States)

    Martino, EC; Misso, G; Pastina, P; Costantini, S; Vanni, F; Gandolfo, C; Botta, C; Capone, F; Lombardi, A; Pirtoli, L; Tassone, P; Ulivieri, C; Tagliaferri, P; Cusi, MG; Caraglia, M; Correale, P

    2016-01-01

    The mPEBev is an anticancer regimen which combines a chemotherapy doublet, based on cisplatin and oral etoposide (mPE), with bevacizumab (mPEBev), a mAb targeting the vasculo-endothelial growth factor (VEGF). In previous studies, this regimen showed powerful anti-angiogenetic effects and significant antitumor activity in metastatic non-small-cell lung cancer (mNSCLC) patients. We also recorded the best benefit in patients exhibiting low-systemic inflammatory profile at baseline. On these bases, we hypothesized that mPEBev antitumor activity could be partially related to bevacizumab-associated immunological effects. For this reason, we performed an immunological monitoring in 59 out of 120 stage IIIb-IV NSCLC patients enrolled in the BEVA2007 phase II trial, who received fractioned cisplatin (30 mg/sqm days 1-3q21) and oral etoposide (50 mg, days 1-15q21) (mPE doublet) ±bevacizumab. In this group of patients, 12 received the mPE doublet alone and 47 the doublet in combination with bevacizumab (5 mg/kg on the day 3q21; mPEBev regimen). Blood cell counts, serum analysis, multiplex cytokine assay and immunocytofluorimetric analysis, performed on baseline and post-treatment on blood samples from these patients, revealed that bevacizumab addition to the doublet decreased levels of pro-angiogenic (VEGF, Angiostatin-1 and Follistatin) and inflammatory cytokines (interferon (IFN)γ, IL4 and IL17), improved in vivo and in vitro cytotoxic T-lymphocytes (CTL) response and promoted dendritic cell activation. These results suggest that the mPEBev regimen improve the micro-environmental conditions for an efficient antigen-specific CTL response, making it a feasible candidate regimen to be assessed in combination with immune-checkpoint inhibitors in NSCLC patients.

  19. Modeling extracellular matrix (ECM) alterations in ovarian cancer by multiphoton excited fabrication of stromal models (Conference Presentation)

    Science.gov (United States)

    Campagnola, Paul J.; Ajeti, Visar; Lara, Jorge; Eliceiri, Kevin W.; Patankar, Mansh

    2016-04-01

    A profound remodeling of the extracellular matrix (ECM) occurs in human ovarian cancer but it unknown how this affects tumor growth, where this understanding could lead to better diagnostics and therapeutic approaches. We investigate the role of these ECM alterations by using multiphoton excited (MPE) polymerization to fabricate biomimetic models to investigate operative cell-matrix interactions in invasion/metastasis. First, we create nano/microstructured gradients mimicking the basal lamina to study adhesion/migration dynamics of ovarian cancer cells of differing metastatic potential. We find a strong haptotactic response that depends on both contact guidance and ECM binding cues. While we found enhanced migration for more invasive cells, the specifics of alignment and directed migration also depend on cell polarity. We further use MPE fabrication to create collagen scaffolds with complex, 3D submicron morphology. The stromal scaffold designs are derived directly from "blueprints" based on SHG images of normal, high risk, and malignant ovarian tissues. The models are seeded with different cancer cell lines and this allows decoupling of the roles of cell characteristics (metastatic potential) and ECM structure and composition (normal vs cancer) on adhesion/migration dynamics. We found the malignant stroma structure promotes enhanced migration and proliferation and also cytoskeletal alignment. Creating synthetic models based on fibers patterns further allows decoupling the topographic roles of the fibers themselves vs their alignment within the tissue. These models cannot be synthesized by other conventional fabrication methods and we suggest the MPE image-based fabrication method will enable a variety of studies in cancer biology.

  20. ALOKASI PASOKAN BERDASARKAN PRODUK UNGGULAN UNTUK RANTAI PASOK SAYURAN SEGAR

    Directory of Open Access Journals (Sweden)

    Marimin Marimin

    2007-01-01

    Full Text Available Application of artificial inteligent by using fuzzy logic can be one of way to handle supply chain situation in uncertainty environment. It was widely concern to study a supply chain using fuzzy logic that most needed. Ain of the study was apply fuzzy logic in determination of supply allocation for superior product in vegetables supply chain. Models was developed in three sub models. First was determination vegetables types that superior by using pareto technique and exponential compaarison method (MPE. Second was expert system to determine supply needed and finally was optimizing supply allocation using fuzzy multi-objective linear programming. The model was applied in a vegetables agroindustry that superior product selected was red paprica. Analysis againts model behaviour is conducted for pesimistic and optimistic scenarios. Abstract in Bahasa Indonesia : Penerapan kecerdasan buatan dengan logika fuzzy bisa menjadi salah satu cara untuk mengatasi situasi rantai pasok dalam lingkungan ketidakpastian. Perhatian yang lebih luas untuk pembahasan rantai pasok menggunakan teknik fuzzy masih sangat dibutuhkan. Studi ini bertujuan menerapkan logika fuzzy dalam penentuan alokasi pasokan untuk produk unggulan pada rantai pasok agroindustri sayuran. Model yang terdiri dari tiga sub model. Sub model pertama adalah penentuan jenis sayuran yang diunggulkan menggunakan kombinasi teknik pareto dan metode perbandingan eksponensial (MPE. Sub model kedua adalah sistem pakar untuk menentukan kebutuhan pasokan menggunakan logika fuzzy. Sub model ketiga adalah optimasi alokasi pasokan menggunakan programa linear obyektif majemuk fuzzy. Model yang dibangun kemudian diterapkan pada sebuah perusahaan agroindustri sayuran dengan produk unggulan terpilih adalah paprika merah. Analisis terhadap prilaku model juga dilakukan untuk skenario pesimis dan optimis. Kata kunci: fuzzy, sistem pakar, MPE, obyektif majemuk, sayuran

  1. Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

    Science.gov (United States)

    Starnowska, Joanna; Costante, Roberto; Guillemyn, Karel; Popiolek-Barczyk, Katarzyna; Chung, Nga N; Lemieux, Carole; Keresztes, Attila; Van Duppen, Joost; Mollica, Adriano; Streicher, John; Vanden Broeck, Jozef; Schiller, Peter W; Tourwé, Dirk; Mika, Joanna; Ballet, Steven; Przewlocka, Barbara

    2017-07-26

    The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronociceptive systems such as substance P. We present evidence to support this hypothesis in this work from the spinal cord in a neuropathic pain model in mice. Biochemical analysis confirmed the elevated mRNA and protein level of pronociceptive substance P, the major endogenous ligand of the neurokinin-1 (NK1) receptor, in the lumbar spinal cord of chronic constriction injury (CCI)-mice. To improve opioid efficacy in neuropathic pain, novel compounds containing opioid agonist and neurokinin 1 (NK1) receptor antagonist pharmacophores were designed. Structure-activity studies were performed on opioid agonist/NK1 receptor antagonist hybrid peptides by modification of the C-terminal amide substituents. All compounds were evaluated for their affinity and in vitro activity at the mu opioid (MOP) and delta opioid (DOP) receptors, and for their affinity and antagonist activity at the NK1 receptor. On the basis of their in vitro profiles, the analgesic properties of two new bifunctional hybrids were evaluated in naive and CCI-mice, representing models for acute and neuropathic pain, respectively. The compounds were administered to the spinal cord by lumbar puncture. In naive mice, the single pharmacophore opioid parent compounds provided better analgesic results, as compared to the hybrids (max 70% MPE), raising the acute pain threshold close to 100% MPE. On the other hand, the opioid parents gave poor analgesic effects under neuropathic pain conditions, while the best hybrid delivered robust (close to 100% MPE) and long lasting alleviation of both tactile and thermal hypersensitivity. The results presented emphasize the potential of opioid/NK1 hybrids in view of analgesia under nerve injury conditions.

  2. Effect of optical turbulence along a downward slant path on probability of laser hazard

    Science.gov (United States)

    Gustafsson, K. Ove S.

    2016-10-01

    The importance of the optical turbulence effect along a slant path downward on probability of exceeding the maximum permissible exposure level (MPE) from a laser is discussed. The optical turbulence is generated by fluctuations (variations) in refractive index of the atmosphere. These fluctuations are caused in turn by changes in atmospheric temperature and humidity. The structure function of refractive index, Cn2, is the single most important parameter in the description of turbulence effects on the propagation of electromagnetic radiation. In the boundary layer, the lowest part of the atmosphere where the ground directly influence the atmosphere, is the variation of Cn2 in Sweden between about 10-17 and 10-12 m-2/3, see Bergström et al. [5]. Along a horizontal path is the Cn 2 often assumed to be constant. The variation of the Cn2 along a slant path is described by the Tatarski model as function of height to the power of -4/3 or -2/3, depending on day or night conditions. The hazard of laser damage of eye is calculated for a long slant path downward. The probability of exceeding the maximum permissible exposure (MPE) level is given as a function of distance in comparison with nominal ocular hazard distance (NOHD) for adopted levels of turbulence. Furthermore, calculations are carried out for a laser pointer or a designator laser from a high altitude and long distance down to a ground target. The used example shows that there is an 10% risk of exceeding the MPE at a distance 2 km beyond the NOHD, in this example 48 km, due to turbulence level of 5·10-15 m-2/3 at ground height. The turbulence influence on a laser beam along horizontal path on NOHD have been shown before by Zilberman et al. [4].

  3. Sensitivity of Beauveria bassiana conidia to abiotic factors after successive in vitro subcultures

    Directory of Open Access Journals (Sweden)

    Janaina Zorzetti

    2014-09-01

    Full Text Available The aim of this study was to evaluate the effect of in vitro successive subcultures of Beauveria bassiana isolates in different nutritional conditions on conidia heat and UV radiation tolerance and on sensitivity to azoxystrobin fungicide. The fungus was initially inoculated in Alphitobius diaperinus (Coleoptera: Tenebrionidae adults and after its development, the conidia were cultivated in PDA (potato dextrose agar and MPE (medium to produce Beauveria spp. conidia originating the first subculture 1st (A conidia, which were successively multiplied in their media until the 20th cultivation. Conidia taken from the 20th subculture were again inoculated in the insect and after sporulation they were once more multiplied in the media, producing the 1st (B conidia. For the tests, 1st (A, 10th, 20th and 1st (B conidia from the CG 152 and Unioeste 40 isolates were used. Successive subcultures and the medium nutritional conditions interfered on the fungus physiology, and the isolates showed different behaviors. The subcultures on PDA showed higher thermotolerance to Unioeste 40 in all subcultures and to CG 152 just after inoculation in the host. B. bassiana was susceptible to UV radiation, and this characteristic was influenced by the subcultures in different media. Both isolates were more tolerant to UV radiation when subcultivated on MPE, while just for the 40 Unioeste this tolerance increased after host inoculation. The B. bassiana sensitivity to azoxystrobin fungicide was affected after successive subcultures in both medium. Conidia originated in MPE were more resistant to fungicide and the host inoculation increased this tolerance. These results show that it is possible to enhance the fungi efficiency to control pests, through the selection of a virulent isolate, and handling their nutritional conditions during cultivation and host inoculation.

  4. 高聚金葡素及顺铂疗恶性胸腔积液38例

    Institute of Scientific and Technical Information of China (English)

    黄和平; 王德猛

    2001-01-01

    @@ 恶性胸腔积液(malignant pleural effusion,MPE)是晚期癌肿的常见并发症,直接影响患者的心肺功能和生存期,应及时处理.高聚金葡素(highly agglutinative staphylococcin,HAS)是一种新的生物免疫制剂,为了比较HAS和顺铂(diamminedichloroplation,DDP)对缓解MPE的作用,我院自1994年4月始用HAS或DDP治疗MPE共38例,现报告如下.

  5. Different effects of L-arginine on morphine tolerance in sham and ovariectomized female mice

    Institute of Scientific and Technical Information of China (English)

    Reza KARAMI; Mahmoud HOSSEINI; Fatimeh KHODABANDEHLOO; Leila KHATAMI; Zahra TAIARANI

    2011-01-01

    Objective: The roles of gonadal hormones and nitric oxide (NO) on the analgesic effects of morphine,tolerance to morphine,and their interactions have been widely investigated.In the present study,the effect of L-arginine (an NO precursor) on morphine tolerance in sham and ovariectomized (OVX) female mice was investigated.Methods: Forty mice were divided into sham and OVX groups.On the first day,a hot plate test ((55±0.2) ℃; cut-off 30 s)was carried out as a base record 15 min before injection of morphine (10 mg/kg,subcutaneously (s.c.)) and was repeated every 15 min after injection.The sham group was then divided into two subgroups: sham-toleranceL-arginine (Sham-ToI-LA) and sham-tolerance-saline (Sham-ToI-Sal) which received either L-arginine 50 mg/kg (intraperitoneally (i.p.)) or saline 10 mi/kg (i.p.),respectively,three times in a day for three consecutive days.Morphine tolerance was induced in animals by injecting 30 mg/kg morphine (s.c.) three times/day for three days.This treatment was also used for OVX subgroups.On the fifth day,the hot plate test was repeated.The analgesic effect of morphine was calculated as the maximal percent effect (MPE).The results were compared using repeated measure analysis of variance (ANOVA).Results: There was no significant difference in MPE between the OVX and sham groups.The MPEs in both the Sham-ToI-Sal and OVX-ToI-Sal groups were lower than those in both the sham and OVX groups (P<0.01).The MPE in the OVX-ToI-Sal group was greater than that in the Sham-ToI-Sal group (P<0.01).The MPE in the Sham-ToI-LA group was higher than that in the Sham-ToI-Sal group (P<0.01).However,there was no significant difference between the Sham-ToI-LA and sham groups or between the OVX-ToI-LA and OVX-ToI-Sal groups.Conclusions: The results of the present study showed that repeated administration of morphine causes tolerance to the analgesic effect of morphine.L-Arginine could prevent tolerance to morphine but its effect was different in

  6. GRAVITY: the VLTI 4-beam combiner for narrow-angle astrometry and interferometric imaging

    CERN Document Server

    Blind, N; Gillessen, S; Kok, Y; Lippa, M; Perrin, G; Dembet, R; Fedou, P; Lacour, S; Perraut, K; Jocou, L; Burtscher, L; Hans, O; Haug, M; Haussmann, F; Huber, S; Janssen, A; Kellner, S; Ott, T; Pfuhl, O; Sturm, E; Weber, J; Wieprecht, E; Amorim, A; Brandner, W; Straubmeier, C

    2015-01-01

    GRAVITY is the second generation Very Large Telescope Interferometer instrument for precision narrow-angle astrometry and interferometric imaging in the Near Infra-Red (NIR). It shall provide precision astrometry of order 10 microarcseconds, and imaging capability at a few milliarcsecond resolution, and hence will revolutionise dynamical measurements of celestial objects. GRAVITY is currently in the last stages of its integration and tests in Garching at MPE, and will be delivered to the VLT Interferometer (VLTI) in 2015. We present here the instrument, with a particular focus on the components making use of fibres: integrated optics beam combiners, polarisation rotators, fibre differential delay lines, and the metrology.

  7. Discovery of colorectal cancer PIK3CA mutation as potential predictive biomarker: power and promise of molecular pathological epidemiology.

    Science.gov (United States)

    Ogino, S; Lochhead, P; Giovannucci, E; Meyerhardt, J A; Fuchs, C S; Chan, A T

    2014-06-05

    Regular use of aspirin reduces incidence and mortality of various cancers, including colorectal cancer. Anticancer effect of aspirin represents one of the 'Provocative Questions' in cancer research. Experimental and clinical studies support a carcinogenic role for PTGS2 (cyclooxygenase-2), which is an important enzymatic mediator of inflammation, and a target of aspirin. Recent 'molecular pathological epidemiology' (MPE) research has shown that aspirin use is associated with better prognosis and clinical outcome in PIK3CA-mutated colorectal carcinoma, suggesting somatic PIK3CA mutation as a molecular biomarker that predicts response to aspirin therapy. The PI3K (phosphatidylinositol-4,5-bisphosphonate 3-kinase) enzyme has a pivotal role in the PI3K-AKT signaling pathway. Activating PIK3CA oncogene mutations are observed in various malignancies including breast cancer, ovarian cancer, brain tumor, hepatocellular carcinoma, lung cancer and colon cancer. The prevalence of PIK3CA mutations increases continuously from rectal to cecal cancers, supporting the 'colorectal continuum' paradigm, and an important interplay of gut microbiota and host immune/inflammatory reaction. MPE represents an interdisciplinary integrative science, conceptually defined as 'epidemiology of molecular heterogeneity of disease'. As exposome and interactome vary from person to person and influence disease process, each disease process is unique (the unique disease principle). Therefore, MPE concept and paradigm can extend to non-neoplastic diseases including diabetes mellitus, cardiovascular diseases, metabolic diseases, and so on. MPE research opportunities are currently limited by paucity of tumor molecular data in the existing large-scale population-based studies. However, genomic, epigenomic and molecular pathology testings (for example, analyses for microsatellite instability, MLH1 promoter CpG island methylation, and KRAS and BRAF mutations in colorectal tumors) are becoming routine

  8. Discovery of Colorectal Cancer PIK3CA Mutation as Potential Predictive Biomarker: Power and Promise of Molecular Pathological Epidemiology

    Science.gov (United States)

    Ogino, Shuji; Lochhead, Paul; Giovannucci, Edward; Meyerhardt, Jeffrey A; Fuchs, Charles S; Chan, Andrew T

    2013-01-01

    Regular use of aspirin reduces incidence and mortality of various cancers, including colorectal cancer. Anti-cancer effect of aspirin represents one of the “Provocative Questions” in cancer research. Experimental and clinical studies support a carcinogenic role for PTGS2 (cyclooxygenase-2), which is an important enzymatic mediator of inflammation, and a target of aspirin. Recent “Molecular Pathological Epidemiology” (MPE) research has shown that aspirin use is associated with better prognosis and clinical outcome in PIK3CA-mutated colorectal carcinoma, suggesting somatic PIK3CA mutation as a molecular biomarker that predicts response to aspirin therapy. The PI3K enzyme plays a pivotal role in the PI3K-AKT signaling pathway. Activating PIK3CA oncogene mutations are observed in various malignancies including breast cancer, ovarian cancer, brain tumor, hepatocellular carcinoma, lung cancer and colon cancer. The prevalence of PIK3CA mutations increases continuously from rectal to cecal cancers, supporting the “colorectal continuum” paradigm, and an important interplay of gut microbiota and host immune/inflammatory reaction. MPE represents an interdisciplinary integrative science, conceptually defined as “epidemiology of molecular heterogeneity of disease”. Because exposome and interactome vary from person to person and influence disease process, each disease process is unique (the unique disease principle). Hence, MPE concept and paradigm can extend to non-neoplastic diseases including diabetes mellitus, cardiovascular diseases, metabolic diseases, etc. MPE research opportunities are currently limited by paucity of tumor molecular data in existing large-scale population-based studies. However, genomic, epigenomic, and molecular pathology testing (e.g., analyses for microsatellite instability, MLH1 promoter CpG island methylation, and KRAS and BRAF mutations in colorectal tumors) is becoming routine clinical practice. In order for integrative molecular

  9. Optimization of biomethanation focusing on high ammonia loaded processes

    OpenAIRE

    WANG, HAN; Angelidaki, Irini; Fotidis, Ioannis

    2016-01-01

    Den toksiske effekt af højt ammoniakniveau udgør et af de mest almindelige problemer i biogasanlæg, som forårsager proces ubalance og nedsat produktion af biogas. Brug af proteinrige substrater (fx gødning fra grise, madaffald, etc.) i biogasanlæg fører til suboptimal udnyttelse af biogaspotentialet og en ustabil biogasproces. Samtidig har det vist sig, at de hidtidige løsninger til at dæmpe den toksiske effekt af ammoniak i fulskala biogasanlæg enten har været for dyre eller tidskrævende. De...

  10. QPS - analysis of main problems, areas to target, possible improvements

    CERN Document Server

    Denz, R

    2012-01-01

    The fault statistics of the LHC Quench Protection System QPS for the LHC run 2011 will be presented and the various fault types explained. Starting with teething and EMC related problems, the tune feedback compatibility, hardware faults of the quench heater power supplies and spurious openings of electrical circuit breakers will be described in more details. Hereby as well the necessary and potential consolidation measures will be discussed. The role of the MPE standby service for the system availability will be addressed. Finally radiation induced faults and the respective mitigation and consolidation measures will be treated as separate subject.

  11. Improving the Accuracy and Scalability of Discriminative Learning Methods for Markov Logic Networks

    Science.gov (United States)

    2011-05-01

    each ex- ample is a verb and all of its semantic arguments in a sentence ( Carreras & Màrquez, 2005). In addition, each example does not contain a...Recently, Riedel (2008) proposed a more efficient method to solve the MPE inference problem called Cutting Plane In- ference (CPI), which does not require...replace the square 2-norm, wTw, on these formulations by the 1-norm, ||w||1 = ∑n i=1 |wi|, 18 Algorithm 2.1 Cutting- plane method for solving the “1

  12. IP over DVB-based DVB-H simulation system%基于IP over DVB的DVB-H仿真系统

    Institute of Scientific and Technical Information of China (English)

    谢嵩; 陈佳品; 李振波

    2009-01-01

    根据对DVB-H协议中的关键技术-时间切片、多协议封装及前向纠错编码(MPE-FEC)以及相关信道编码技术的研究,设计实现了基于IP over DVB的DVB-H仿真系统.实验表明,在所设计系统中,接收端能够完全恢复DVB码流,并利用DirectShow技术实现了对传输码流的实时同步播放.

  13. 一种颗粒饲料 PDI 测试方法的研究%One method of PDI evaluation for pellet feed

    Institute of Scientific and Technical Information of China (English)

    高蕊; 李倪薇; 康宏彬; 王红英

    2013-01-01

    Feed companies often use the tumbler method to determin pellet durability index (PDI) evaluation, which is inefficient and waste a lot of materials. This study was designed for coming up with a new and simple method for pellet durability index(PDI) evaluation, which called MPE(method for pelleting evaluation). Using MPE and the linear equation, we can get the PDI efficiently. This paper choses 541 pellet feed samples with different process techniques and feed formulation,but from the same feed manufacturer, a total of 262 for the study of PDI us-ing tumbler method, and the others for the study of MPE. Based on the experiments a prediction model of PDI about MPE was established by using SPSS(R2>0.96). To compare the predicted value with the actual value, the result showed that the prediction model could predict the PDI values of five different kinds of pellet feed.%研究旨在针对饲料厂目前测定颗粒饲料耐久度PDI值(Pellet Durability Index)存在的问题,提出一种新型而且简单有效的颗粒饲料耐久度测定方法,即MPE法(Method for Pelleting Evaluation)。通过测得MPE值,利用线性相关方程得到PDI值,提高传统测定PDI值的效率。选取同一生产厂家生产的5种不同品种颗粒饲料共计541个,其中262个用回转箱法测定PDI,279个用来测定MPE,利用SPSS统计软件建立起回转箱法测PDI与MPE法测PDI的线性相关性方程。通过试验分析,得到了5种不同颗粒饲料的MPE与PDI的回归模型的预测模型。将预测值与实际值比较,结果显示该预测模型能够比较好地预测这5种不同颗粒饲料的PDI值(R2>0.96)。

  14. A retrospective study on sequential desensitization-rechallenge for antituberculosis drug allergy

    Science.gov (United States)

    Chia, Faith Li-Ann; Tan, Sze-Chin; Tan, Teck-Choon; Leong, Khai-Pang; Tan, Justina Wei-Lyn; Tang, Chwee-Ying; Hou, Jin-Feng; Chan, Grace Yin-Lai; Chng, Hiok-Hee

    2014-01-01

    Background Antituberculosis (anti-TB) drug allergy often involves multiple concurrently administered drugs which subsequently need to be reinitiated as no better alternatives exist. Objective To describe the results of tailored sequential desensitization-rechallenge (D-R) for anti-TB drug allergy. Methods Consecutive patients who had undergone D-R to anti-TB drugs between 1 September 1997 and 31 January 2012 were recruited. Following resolution of the acute reaction, anti-TB drug was restarted at 1:6,000 to 1:3 of the final daily dose (FDD), with gradual single or multiple step daily dose escalation to the FDD. Subsequent drugs were sequentially added ≥3 days later when the preceding drug was tolerated. Full blood count and liver function tests were monitored prior to addition of each new drug. Results There were 11 patients of whom 10 were male, predominantly Chinese (8 patients). Regimens comprised at least 3 drugs: isoniazid (INH), rifampicin (RIF), ethambutol (EMB), pyrazinamide (PZA), or streptomycin. All patients had nonimmediate reactions, with cutaneous eruptions, where maculopapular exanthema (MPE) was the most common (8 patients). Drug-induced hypersensitivity syndrome (DIHS) occurred in 6 patients, and Stevens Johnson syndrome (SJS) in 2 patients. D-R to INH was successful in 7/9 patients (77.8%) and to RIF/EMB/PZA/streptomycin in all. Of the 2 patients who failed INH D-R, 1 developed fever and MPE on day 3, the other MPE on day 8. D-R with INH and RIF respectively was successful in 2 patients with SJS. Among DIHS patients, 1 failed D-R with INH (fever and MPE on day 3). There were 23/25 (92%) successful D-R among the 11 patients. All patients completed TB treatment of ≥5 months' duration with no cases of drug-resistant TB. Conclusion Tailored sequential TB drug D-R is successful where no better alternative therapies are available, with careful dose escalation and close monitoring, and after a careful risk-benefit assessment. PMID:25097851

  15. Sensitivity of Distributed Hydrologic Simulations to Ground and Satellite Based Rainfall Products

    OpenAIRE

    Singaiah Chintalapudi; Hatim O. Sharif; Hongjie Xie

    2014-01-01

    In this study, seven precipitation products (rain gauges, NEXRAD MPE, PERSIANN 0.25 degree, PERSIANN CCS-3hr, PERSIANN CCS-1hr, TRMM 3B42V7, and CMORPH) were used to force a physically-based distributed hydrologic model. The model was driven by these products to simulate the hydrologic response of a 1232 km2 watershed in the Guadalupe River basin, Texas. Storm events in 2007 were used to analyze the precipitation products. Comparison with rain gauge observations reveals that there were signif...

  16. High-temperature piezoelectric materials for elements of linear piezo motors

    Science.gov (United States)

    Khramtsov, A. M.; Spitsin, A. I.; Segalla, A. G.; Ponomarev, S. V.; Rikkonen, S. V.

    2016-11-01

    This paper discusses technological and construction ways to achieve a high working temperature with a high displacement in linear piezo motors. The first part reviews the results of the piezoelectric material development, its temperature stability testing and basic parameters for piezo motors. The second part focuses on the multilayer structure of piezoelectric elements, which are based on high-temperature piezoelectric materials (HTPM). Also analyzed are working temperatures of multilayer piezoelectric elements (MPE) and their hysteresis. Finally, the third part shows a comparison of three recent prototypes of high-temperature MPEs that were in our lab using different materials.

  17. Sensitivity of Distributed Hydrologic Simulations to Ground and Satellite Based Rainfall Products

    OpenAIRE

    Singaiah Chintalapudi; Hatim O. Sharif; Hongjie Xie

    2014-01-01

    In this study, seven precipitation products (rain gauges, NEXRAD MPE, PERSIANN 0.25 degree, PERSIANN CCS-3hr, PERSIANN CCS-1hr, TRMM 3B42V7, and CMORPH) were used to force a physically-based distributed hydrologic model. The model was driven by these products to simulate the hydrologic response of a 1232 km2 watershed in the Guadalupe River basin, Texas. Storm events in 2007 were used to analyze the precipitation products. Comparison with rain gauge observations reveals that there were signif...

  18. Little South Fork Wild River Environmental Inventory. Cummerland River Basin. (Mile 15.4 to 4.0 Mile). Wayne & McCreary Counties, Kentucky,

    Science.gov (United States)

    1982-01-01

    NUMBER OF PAGES WHICH DO NOT REPRODUCE LEGIBLY. • ~ ~ ~ ~ .MW| -!I CORPS OF ENGINEERS Legend SI MAP SET A, OWNERSHIP AND ACCESS Tate- Trappist stonm 25 to...12 to 20 percent slopes .Forest and Woodlar MpE .Muse- Trappist silt boars. Approximnate bound. 20 to 30 percent slopes of riarkedly differer MpF .Muse... Trappist siltlbarns, vdi h oetd 30 to 50 percent slopes AW Al ivial Woodlands No .Notin silt loam, CL .C itt Habitat 0 to 2 percent slopes DM

  19. Staff Association membership is free of charge for the rest of 2017

    CERN Multimedia

    Staff Association

    2017-01-01

    Starting from September 1st, membership of the Staff Association is free for all new members for the period up to the end of 2017. This is to allow you to participate in the Staff Council elections. Indeed, only Employed Members of the Personnel (MPE: staff and fellows) and Associated Members of the Personnel (MPA), who are members of the Staff Association, can: stand for election and become a delegate of the personnel; vote and elect their representatives to the Staff Council. Do not hesitate any longer; join now!

  20. Search for gamma-ray continuum emission at MeV energies from the Galactic center region

    Energy Technology Data Exchange (ETDEWEB)

    Schoenfelder, V.; Von Ballmoos, P.; Diehl, R.

    1988-12-01

    Constraints on the continuum emission of the Galactic center region at MeV energies were derived from balloon flight data of the MPE Compton telescope. The Galactic center point source flux was found to be less than 0.0028/sq cm s between 0.6 and 3.0 MeV, implying that the source was in a low-intensity state during the time of observation (Oct. 31, 1982) as opposed to the high-intensity state observed by HEAO 3 during the fall of 1979. 23 references.

  1. A Fresnel zone plate collimator: potential and aberrations

    Science.gov (United States)

    Menz, Benedikt; Bräuninger, Heinrich; Burwitz, Vadim; Hartner, Gisela; Predehl, Peter

    2015-09-01

    A collimator, that parallelizes an X-ray beam, provides a significant improvement of the metrology to characterize X-ray optics for space instruments at MPE's PANTER X-ray test facility. A Fresnel zone plate was selected as a collimating optic, as it meets a good angular resolution 10 cm2. Such an optic is ideally suited to illuminate Silicon Pore Optic (SPO) modules as proposed for ATHENA. This paper provides the theoretic description of such a Fresnel zone plate especially considering resolution and efficiency. Based on the theoretic results the collimator setup performance is analyzed and requirements for fabrication and alignment are calculated.

  2. Increasing the sensitivity of a Shack-Hartmann sensor

    CERN Document Server

    Kasper, Markus; Hippler, Stefan; Davies, Ric; Glindemann, Andreas

    2016-01-01

    The Max-Planck institutes for astronomy (MPIA) and for extraterrestrial physics (MPE) run an adaptive optics (AO) system with a laser guide star at the 3.5 m telescope on Calar Alto, Spain. This system, called ALFA, produces now scientific results and works ex- cellent with natural guide stars (NGS) as faint as 13th magnitude in R-band. The ultimate goal however is to achieve similar performances with the laser guide star (LGS) which is faint and extended. We introduce the Shack-Hartmann wavefront sensor implemented in ALFA and present our efforts in increasing its sensitivity by using advanced centroiding and wavefront reconstruction algorithms.

  3. 儿童原发性夜间遗尿症发病机制研究进展

    Institute of Scientific and Technical Information of China (English)

    吕麟亚; 李旭良

    2003-01-01

    @@ 根据1998年国际儿童尿控协会(ICCS)标准,原发性夜间遗尿症(primiary nocturnal enuresis,PNE)是指连续发生夜间遗尿达6个月以上,年龄大于5岁者,根据是否合并白天的症状,PNE又可分为原发性单症状性遗尿(monosymptomatic primary enuresis,MPE)和复杂性遗尿(complicated primary enuresis CPE)[1].

  4. The ethics of physicists in questions

    CERN Multimedia

    2000-01-01

    Four CERN physicists, Peggie Rimmer, Ugo Amaldi, Alain Blondel, and Jean-Marie Le Goff, answered questions from 150 college students last Monday during a debate on the theme of the ethics of physics. Organized by CERN and the Department of public instruction of the Canton of Geneva, the meeting followed a reading by the students of the play Die Physiker, by Friedrich Dürrenmatt, which raises the problem of political exploitation of discoveries made during the second world war. The Minister of Education of the Canton de Genève, Mrs Martine Brunschwig-Graf, took part in the debate. The questions posed by students were not lacking in pertinence : Should a physicist reveal a discovery that is dangerous in his opinion ? Who are responsible, those who make the discoveries or those who use them ?

  5. List of Participants

    Science.gov (United States)

    2007-11-01

    Mohab Abou ZeidVrije Universiteit, Brussel Joke AdamKatholieke Universiteit Leuven Nikolas AkerblomMax-Planck-Institut für Physik, München Luis Fernando Alday Utrecht University Stelios Alexandris University of Patras Antonio Amariti Università di Milano-Bicocca Nicola Ambrosetti Université de Neuchâtel Pascal Anastasopoulos Università di Roma Tor Vergata Laura Andrianopoli Enrico Fermi Center Carlo Angelantonj Università di Torino Lilia Anguelova Queen Mary, University of London Daniel AreanUniversidade de Santiago de Compostela Gleb ArutyunovUtrecht University Spyros Avramis NTU Athens—University of Patras Ioannis Bakas University of Patras Subrata Bal Dublin Institute for Advanced Studies Igor Bandos Valencia University Jessica Barrett University of Iceland Marco Baumgartl Eidgenössische Technische Hochschule, Zürich Jacopo Bechi Università di Firenze James Bedford Queen Mary, University of London Jorge Bellorin Universidad Autonoma de Madrid Francesco Benini SISSA, Trieste Eric Bergshoeff Centre for Theoretical Physics, University of Groningen Gaetano BertoldiUniversity of Wales, Swansea Adel Bilal Laboratoire de Physique Théorique, École Normale Superieure, Paris Matthias Blau Université de Neuchâtel Johannes BroedelUniversität Hannover Felix Brümmer Universität Heidelberg Julio Cesar Bueno de Andrade São Paulo State University—UNESP Cliff Burgess McMaster University Agostino Butti Laboratoire de Physique Théorique, École Normale Superieure, Paris Marco Caldarelli Universitat de Barcelona Pablo G Camara Centre de Physique Théorique, École Polytechnique, Palaiseau Joan Camps Universitat de Barcelona Felipe Canoura FernandezUniversidade de Santiago de Compostela Luigi Cappiello Università di Napoli Federico II Luca Carlevaro École Polytechnique, Palaiseau Roberto Casero Centre de Physique Théorique, École Polytechnique, Palaiseau Claudio Caviezel Max-Planck-Institut für Physik, München Alessio Celi Universitat de Barcelona Anna

  6. Supraleitung Grundlagen und Anwendungen

    CERN Document Server

    Buckel, Werner

    2004-01-01

    Seit nunmehr drei Jahrzehnten ist der "Buckel" das Referenzwerk in deutscher Sprache zum Thema Supraleitung. Immer wieder aktualisiert, hat das Lehrbuch Generationen von Studenten begleitet. In der 6., vollständig überarbeiteten Auflage wird das bewährte didaktische Konzept beibehalten, inhaltlich wurde der Band dem aktuellen Stand von Forschung und Technik angepasst. Das Autorenteam um Prof. Kleiner verzichtet auf komplizierte mathematische Herleitungen. Es baut ganz auf das bewährte Step-by-Step-Prinzip: Der Schwierigkeitsgrad wird von Kapitel zu Kapitel gesteigert. So können auch Einsteiger ohne einschlägige Vorkenntnisse dem Stoff bequem folgen. Dank seiner klaren Sprache und zahlreicher Abbildungen eignet sich der Band hervorragend als einführendes Lehrbuch - und zwar nicht nur für Physik-Studenten, sondern auch für Studierende angrenzender Natur- und Ingenieurwissenschaften. Grundlegende Eigenschaften, supraleitende Elemente, Cooper-Paarung, Thermodynamik, kritische Ströme, Josephsonkontakte...

  7. How Einstein Got His Field Equations

    CERN Document Server

    Walters, Sam

    2016-01-01

    We study the pages in Albert Einstein's 1916 landmark paper in the Annalen der Physik where he derived his field equations for gravity. Einstein made two heuristic and physically insightful steps. The first was to obtain the field equations in vacuum in a rather geometric fashion. The second step was obtaining the field equations in the presence of matter from the field equations in vacuum. (This transition is an essential principle in physics, much as the principle of local gauge invariance in quantum field theory.) To this end, we go over some quick differential geometric background related to curvilinear coordinates, vectors, tensors, metric tensor, Christoffel symbols, Riemann curvature tensor, Ricci tensor, and see how Einstein used geometry to model gravity.

  8. Teilchenphysik und Kosmologie eine Einführung in Grundlagen und Zusammenhänge

    CERN Document Server

    Treichel, Michael

    2000-01-01

    Als einführendes Lehrbuch in die Teilchenastrophysik konzipiert wendet sich dieses Werk an Studenten der Physik und Astronomie ab dem Vordiplom. Kurz und prägnant werden die Grundlagen der Relativitätstheorie und der Quantenmechanik vorgestellt, bevor das Standardmodell der Teilchenphysik erläutert und die Zusammenhänge mit den heutigen Fragen aus Astrophysik und Kosmologie hergestellt werden. Mathematisch elementarer als die meisten Einführungen in die Teilchenphysik eignet sich dieses Buch sowohl begleitend zu einer Kursvorlesung als auch zum Selbststudium. Besonderer Wert wird auf pädagogische Aspekte gelegt: im Vordergrund stehen Anschaulichkeit, eine am tatsächlichen Denkprozess orientierte Darstellung und die Ausgewogenheit zwischen theoretischen, experimentellen und interpretatorischen Aspekten der modernen Astroteilchenphysik.

  9. Technical presentation

    CERN Multimedia

    GS Department

    2010-01-01

    10 March 2010 DYNEOS 10:00 – 12:00 - Main Building, Room B, 61-1-009 Dyneos AG is active in the fields of photonics, laser and high-precision positioning. Our highly qualified engineer team has more than 30 years of experience in electro-optical solutions sales. The engineers are supported by a technical and administrative team. We are focused on the Swiss market and represent six suppliers (Coherent, PI Physik Instrumente, SIOS, Nanonics Imaging, APE, Ekspla) in order to give a qualified sales and service support to our customers. Our products are dedicated to the research field as well as to industry. In addition to standard catalog products, we offer custom designs to fulfill the specific needs of OEM customers or specific applications.

  10. Mathematical analysis and numerical methods for science and technology

    CERN Document Server

    Dautray, Robert

    These 6 volumes - the result of a 10 year collaboration between the authors, two of France's leading scientists and both distinguished international figures - compile the mathematical knowledge required by researchers in mechanics, physics, engineering, chemistry and other branches of application of mathematics for the theoretical and numerical resolution of physical models on computers. Since the publication in 1924 of the "Methoden der mathematischen Physik" by Courant and Hilbert, there has been no other comprehensive and up-to-date publication presenting the mathematical tools needed in applications of mathematics in directly implementable form. The advent of large computers has in the meantime revolutionised methods of computation and made this gap in the literature intolerable: the objective of the present work is to fill just this gap. Many phenomena in physical mathematics may be modeled by a system of partial differential equations in distributed systems: a model here means a set of equations, which ...

  11. A collection of problems for physics teaching

    Energy Technology Data Exchange (ETDEWEB)

    Groeber, S; Jodl, H-J, E-mail: groeber@rhrk.uni-kl.d [Department of Physics, University of Technology Kaiserslautern, Erwin-Schroedinger-Strasse, D-67663 Kaiserslautern (Germany)

    2010-07-15

    Problems are an important instrument for teachers to mediate physics content and for learners to adopt this content. This collection of problems is not only suited to traditional teaching and learning in lectures or student labs, but also to all kinds of new ways of teaching and learning, such as self-study, long-distance teaching, project-oriented learning and the use of remote labs/web experiments. We focus on Rutherford's scattering experiment, electron diffraction, Millikan's experiment and the use of pendulums to measure the dependence of gravitational acceleration on latitude. The collection contains about 50 problems with 160 subtasks and solutions, altogether 100 pages. Structure, content, range and the added value of the problems are described. The whole collection can be downloaded for free from http://rcl.physik.uni-kl.de.

  12. Nano-physics and bio-electronics a new odyssey

    CERN Document Server

    Chakraborty, T; Sivan, U

    2002-01-01

    This book is a collection of some of the invited talks presented at the international meeting held at the Max Planck Institut fuer Physik Komplexer Systeme, Dresden, Germany during August 6-30, 2001, on the rapidly developing field of nanoscale science in science and bio-electronics Semiconductor physics has experienced unprecedented developments over the second half of the twentieth century. The exponential growth in microelectronic processing power and the size of dynamic memorie has been achieved by significant downscaling of the minimum feature size. Smaller feature sizes result in increased functional density, faster speed, and lower costs. In this process one is reaching the limits where quantum effects and fluctuations are beginning to play an important role. This book reflects the achievements of the present times and future directions of research on nanoscopic dimensions.

  13. Quantenmechanik im Kalten Krieg David Bohm und Richard Feynman

    CERN Document Server

    Forstner, Christian

    2007-01-01

    Mitte des 20. Jahrhunderts entwickelten David Bohm und Richard Feynman zwei grundlegend verschiedene Ansätze der moderne Quantenmechanik: Bohm eine realistische Deutung mit Hilfe verborgener Parameter und Feynman den Pfadintegralformalismus. Dies ist umso bemerkenswerter, weil beide Physiker von ähnlichen Voraussetzungen ausgingen und aus ähnlichen Zusammenhängen stammten. Durch ihren vergleichenden Ansatz bietet diese Studie mehr als einen Beitrag zur Geschichte der Quantentheorie. Mit der Frage nach den sozialen und kulturellen Bedingungen der Theoriebildung ist sie darüberhinaus von wissenschaftssoziologischem und wissenschaftstheoretischem Interesse. Die anfangs ähnliche und später unterschiedliche Einbindung der beiden Wissenschaftler in die Scientific Community erlaubt es überdies zu untersuchen, welchen Anpassungsdruck die jeweilige Gruppe auf den individuellen Wissenschaftler und die Kernbestandteile seiner Forschungen ausübt und welche neuen Freiheitsgrade für die Theoriebildung entstehen, ...

  14. Otázka slobodnej vôle v helenistickej filozofii (na pozadí Ciceronovho spisu De fato (Die Frage des freien Willens in der hellenistischen Philosophie (In Anbetracht der Ciceros Schrift De fato

    Directory of Open Access Journals (Sweden)

    Peter Fraňo

    2010-06-01

    Full Text Available In diesem Beitrag ich beschäftige mich mit der Frage: Ist das menschliche handeln vorbestimmt, oder kann der Einzelne frei entscheiden? Diese problematik wurde in der hellenistischen Philosophie sehr verbreitet. Das erste mal hat diese Frage Aristoteles in seinen Werken: Die Nikomachische Etik und vor allem De Interpretatione erforscht, wo hat sich die logische Problematik des sogenannten περὶ δυνατῶν berührt. Die megarischen Philosophen Diodoros Kronos und Philon von Megara hat auf die Lösung des Aristoteles reagiert. Außer der Logik ist die Problematik des freien Willes der Bestandteil der stoischen Physik (Astrologie, Sympathie uns stoische Ursachen gewesen. In meinem Beitrag ich habe auf diese Gesichtspunkte in Anbetracht der Ciceros Schrift De fato hingewiesen.

  15. The Discovery of First-Degree Relativity and the Refutation of Gamma

    CERN Document Server

    Mathis, M

    2000-01-01

    In pursuit of the solution to the Pioneer Anomaly, I have returned to Einstein's paper "On the Thermodynamics of Moving Bodies" (Annalen der Physik,1905)and to the book RELATIVITY (1916). I do not question the underlying theory of Special Relativity, meaning that I accept time dilation and length contraction. I assume that there must be transformation equations and that the equations of Einstein are very close to correct, due to experimental confirmation. However, in this paper I put the basic algebra under a microscope, and do a thorough analysis of Einstein's mathematical equations in both places. I show that several errors were made that subtly change the form and content of the necessary transformation equations. I show all my math, and present the corrected equations. These equations yield a tiny fractional correction to Special Relativity, and explain the greater slowing in the Pioneer Anomaly. I show, furthermore, that Einstein's equation for velocity yields two degrees of relativity. I present a veloc...

  16. Ab initio approach to the ion stopping power at the plasma-solid interface

    Science.gov (United States)

    Bonitz, Michael; Schlünzen, Niclas; Wulff, Lasse; Joost, Jan-Philip; Balzer, Karsten

    2016-10-01

    The energy loss of ions in solids is of key relevance for many applications of plasmas, ranging from plasma technology to fusion. Standard approaches are based on density functional theory or SRIM simulations, however, the applicability range and accuracy of these results are difficult to assess, in particular, for low energies. Here we present an independent approach that is based on ab initio nonequilibrium Green functions theory, e.g. that allows to incorporate electronic correlations effects of the solid. We present the first application of this method to low-temperature plasmas, concentrating on proton and alpha-particle stopping in a graphene layer. In addition to the stopping power we present time-dependent results for the local electron density, the spectral function and the photoemission spectrum that is directly accessible in optical, UV or x-ray diagnostics. http://www.itap.uni-kiel.de/theo-physik/bonitz/.

  17. Wer im Treibhaus sitzt wie wir der Klima- und Energiefalle entkommen

    CERN Document Server

    Kleinknecht, Konrad

    2007-01-01

    Deutschland leistet sich eine verlogene Debatte um die Zukunftsfrage schlechthin: Wie entkommen wir der Energie- und Klimafalle? Mit Parolen aus den Siebzigerjahren (»Atom­kraft – nein danke!«) und Vogel-Strauß-Politik verspielen wir unsere Zukunft als Industrienation. Konrad Kleinknecht zeigt, wie alarmierend die Situation ist. Schon bald wird die Klimaänderung dazu führen, dass Millionen Menschen nach Europa kommen, weil ihre Lebensräume unbewohnbar geworden sind, schon bald wird Energie, der Lebenssaft unserer Zivilisation, nicht mehr ausreichend verfügbar oder bezahlbar sein. Als Physiker kann Kleinknecht klar nachweisen, dass der bisherige Energiekurs, das Setzen auf fossile Energien, in den Untergang führt.

  18. Quantenmechanik verstehen eine Einführung in den Welle-Teilchen-Dualismus für Lehrer und Studierende

    CERN Document Server

    Pietschmann, Herbert

    2003-01-01

    Der bekannte Autor H. Pietschmann wendet sich mit diesem Buch an Physiklehrer an höheren Schulen und an Physikstudenten im Anschluß an deren Grundausbildung. Quantenmechanik entzieht sich der Anschaulichkeit, wie wir sie von der klassischen Physik her kennen, aber - und das ist das Kernthema des Buchs - man kann sie sehr wohl verstehen. H. Pietschmann gelingt es, dies mit einfachen Mitteln zu erreichen, und damit gibt er Lehrerinnen und Lehrern eine Unterrichtshilfe und Studenten eine Einführung in die anspruchsvollen Hochschultexte an die Hand. Die mathematische Behandlung spielt keine zentrale Rolle, vielmehr wird versucht, der Interpretation und dem Denken in quantenmechanischen Kategorien breiten Raum zu geben. Behandelt werden z.B. die Quantenhypothese unter Einbeziehung der Geschichte dieses Konzepts, die Schrödingertheorie, die Interpretation der Wellenfunktion und der Messprozess, die Ein- und Mehrelektronenatome sowie Fragen der Zeitabhängigkeit.

  19. Gender-Kompetenz – Vermittlung im Kontext Schule: Von Widerständen, dem Wunsch nach fertigen Rezepten und von möglichen Lösungen

    Directory of Open Access Journals (Sweden)

    Kathrin Nachtsheim

    2009-03-01

    Full Text Available Die Autorinnen beschreiben, wie eine Vermittlung von Gender-Kompetenz im Sinne des Gender Mainstreaming an Schulen erfolgen kann und mit welchen Vorbehalten und Widerständen sie es zu tun hat. Schulen als elementare Bildungseinrichtungen sind wichtige gesellschaftliche Institutionen wenn es um Gender Mainstreaming geht und darum, Entwicklungschancen jenseits von geschlechterstereotypen Zuschreibungen zu ermöglichen. Im Bereich Schule zeigen sich ganz aktuell verschiedene genderanalytische Ansatzpunkte: Jungen, die als ‚Verlierer des Bildungssystems’ bezeichnet werden, Mädchen, denen trotz der besseren Schulabschlüsse seltener berufliche Karrieren gelingen und die aus einem sehr kleinen Berufswahlspektrum wählen. Wie sind Jungen für Lesen und Mädchen für Physik zu begeistern? Welche Geschlechterrollenstereotype sind wirksam und wo kann Schule an Veränderungen mitwirken? Welche Kompetenzen benötigen Schulen, Schulleiter/-innen und Lehrer/-innen?

  20. Fluid mechanics for mechanical engineering. Technology and examples; Stroemungslehre fuer den Maschinenbau. Technik und Beispiele

    Energy Technology Data Exchange (ETDEWEB)

    Siekmann, H.E. [Technische Univ. Berlin (Germany). Hermann-Foettinger-Institut fuer Stroemungsmechanik

    2001-07-01

    The book complements the established fluid mechanics textbook. It discusses the same subjects but goes into more detail and contains many practical examples. It addresses students of engineering, physics and practically oriented mathematics and can be used for independent studying or for a deeper understanding of subject matter treated in university lectures. [German] Der Band stellt als Ergaenzung zum eingefuehrten Grundlagenbuch Stroemungslehre eine tiefergehende Behandlung des Vorlesungsstoffes dar. Die Einteilung der Kapitel entspricht im wesentlichen der im Band Grundlagen: Hydrostatik, Kinematik, Impulssatz, NAVIER-Stokes-Bewegungsgleichung, Potential-, Wirbel- und Grenzschichtstroemung sowie turbulente Stroemung. Das Buch schliesst mit Darstellungen ueber Rohrstroemungen, Umstroemungen von Koerpern, Aehnlichkeitsgesetzen und numerische Stroemungsberechnung. Es enthaelt zahlreiche Praxisbeispiele. Geeignet fuer Studenten der Ingenieurwissenschaften, Physiker und praxisorientierte Mathematiker zum Selbststudium sowie zur Vorlesungsbegleitung. (orig.)

  1. Development of a multi-electrode extrapolation chamber as a prototype of a primary standard for the realization of the unit of the absorbed dose to water for beta brachytherapy sources

    CERN Document Server

    Bambynek, M

    2002-01-01

    The prototype of a primary standard has been developed, built and tested, which enables the realization of the unit of the absorbed dose to water for beta brachytherapy sources. In the course of the development of the prototype, the recommendations of the American Association of Physicists in Medicine (AAPM) Task Group 60 (TG60) and the Deutsche Gesellschaft fuer Medizinische Physik (DGMP) Arbeitskreis 18 (AK18) were taken into account. The prototype is based on a new multi-electrode extrapolation chamber (MEC) which meets, in particular, the requirements on high spatial resolution and small uncertainty. The central part of the MEC is a segmented collecting electrode which was manufactured in the clean room center of PTB by means of electron beam lithography on a wafer. A precise displacement device consisting of three piezoelectric macrotranslators has been incorporated to move the wafer collecting electrode against the entrance window. For adjustment of the wafer collecting electrode parallel to the entranc...

  2. L'influenza di Einstein sul pensiero di Popper

    Directory of Open Access Journals (Sweden)

    Carlo Veronesi

    2016-12-01

    Full Text Available In a BBC radio programme Popper acknowledged his debt to Einstein saying that Einstein’s influence on his thinking was immense and that he mainly made explicit certain points that were implicit in the work of Einstein. In fact, in various writings Einstein presents his critical attitude toward any scientific theory: of particular interest is Einstein’s article «Induktion und Deduktion in der Physik» (1919 that can be considered a concentrate of Popper’s views of science. In the second part of the paper are presented the views of Popper on quantum mechanics and his defense of objectivity and realism. Popper opposes the idea, which he associates with the Copenhagen interpretation, that the theories describing quantum phenomena are about the subjective states of the human observers. Following the lead of Einstein, Popper emphasizes that scientific theories should be interpreted as attempts to describe a mind‐independent reality.

  3. Solid state physics. Introduction to the fundamentals. 7. ed.; Festkoerperphysik. Einfuehrung in die Grundlagen

    Energy Technology Data Exchange (ETDEWEB)

    Ibach, Harald; Lueth, Hans [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Bio- und Nanosysteme; Rheinisch-Westfaelische Technische Hochschule (RWTH), Aachen (Germany)

    2009-07-01

    The present seventh edition of solid-state physics accomodates to the trend to nanophysics in research and teaching. The book applies to studying and teachings of physics, material science, as well as micro- and nanoelectronics. It treats equally experiment and theory. Tables with fundamental experiments, preparation methods, and special physical effects as well as exercise problems round the book off. [German] Die vorliegende siebte Auflage der Festkoerperphysik traegt dem Trend zur Nanophysik in Forschung und Lehre Rechnung. Das Buch wendet sich an Studierende und Lehrende der Physik, der Materialwissenschaft sowie der Mikro- und Nanoelektronik. Es behandelt gleichwertig Experiment und Theorie. Tafeln mit grundlegenden Experimenten, Praeparationsmethoden und speziellen physikalischen Effekten sowie Uebungsaufgaben runden das Buch ab. (orig.)

  4. The neutron lifetime experiment PENeLOPE

    Energy Technology Data Exchange (ETDEWEB)

    Schreyer, Wolfgang [Technische Universitaet Muenchen (Germany); Collaboration: PENeLOPE-Collaboration

    2015-07-01

    The neutron lifetime τ{sub n}=880.3±1.1 s is an important parameter in the Standard Model of particle physics and in Big Bang cosmology. Several systematic corrections of previously published results reduced the PDG world average by several σ in the last years and call for a new experiment with complementary systematics. The experiment PENeLOPE, currently under construction at the Physik-Department of Technische Universitaet Muenchen, aims to determine the neutron lifetime with a precision of 0.1 s. It will trap ultra-cold neutrons in a magneto-gravitational trap using a large superconducting magnet and will measure their lifetime by both neutron counting and online proton detection. This presentation gives an overview over the latest developments of the experiment.

  5. The concept of intelligibility in modern physics (1948).

    Science.gov (United States)

    Feyerabend, Paul K

    2016-06-01

    This is an English translation of Paul Feyerabend's earliest extant essay "Der Begriff der Verständlichkeit in der modernen Physik" (1948). In it, Feyerabend defends positivism as a progressive framework for scientific research in certain stages of scientific development. He argues that in physics visualizability (Anschaulichkeit) and intelligibility (Verständlichkeit) are time-conditioned concepts: what is deemed visualizable in the development of physical theories is relative to a specific historical context and changes over time. He concludes that from time to time the abandonment of visualizability is crucial for progress in physics, as it is conducive to major theory change, illustrating the point on the basis of advances in atomic theory.

  6. Geschichte des SIN

    CERN Document Server

    Pritzker, Andreas

    2013-01-01

    Dieses Buch erzählt die Geschichte des Schweizerischen Instituts für Nuklearforschung (SIN). Das Institut wurde 1968 gegründet und ging 1988 ins Paul Scherrer Institut (PSI) über. Die Gründung des SIN erfolgte in einer Zeit, als die Physik weitherum als Schlüsseldisziplin für die technologische und gesellschaftliche Entwicklung galt. Der Schritt war für ein kleines Land wie die Schweiz ungewöhnliche und zeugte von Mut und Weitsicht. Ungewöhnlich waren der Folge die Leistungen des SIN im weltweiten Vergleich sowie sein Einfluss auf die schweizerische, teils auf die internationale Wissenschaftspolitik.

  7. Anbindung der Detektorkontrolle des ATLAS-Pixeldetektors an das Datennahmesystem und die Conditions-Datenbank sowie erste Studien zur Rekonstruktion von K0s Zerfällen

    CERN Document Server

    Imhäuser, Martin

    Im Jahr 2007 wird am europäischen Kernforschungszentrum CERN mit dem LHC der bislang leistungsfähigste Speicherring der Welt mitsamt vier Großexperimenten seinen Betrieb aufnehmen. Das ATLAS-Experiment wird mit einem Universaldetektor eines dieser Experimente sein. Durch die steigende Komplexität und zunehmende Größe der Teilchendetektoren sind die Anforderungen an eine Überwachung und Kontrolle der Experimente nur noch durch umfangreiche und leistungsstarke Detektorkontrollsysteme zu erfüllen. Neben der Einbindung der Detektorgeometrie in das Detektorkontrollsystem des ATLAS Pixeldetektors als geografischer Ansatz, richtet sich der Hauptaugenmerk dieser Arbeit auf die Anbindung des Pixel Detektorkontrollsystems an das ATLAS Datennahmesystem und die Behandlung der Kommunikation zwischen beiden Systemen sowie die Untersuchung einer Speichermethode von Kenngrößen in einer Conditions-Datenbank. Nachdem in Kapitel 1 ein kurzer Überblick über die zugrunde liegende Physik gegeben wird, befasst sich Kap...

  8. Progress in superconductivity: The Indian Scenario

    Science.gov (United States)

    Multani, Manu; Mishra, V. K.

    1995-01-01

    India has made rapid progress in the field of high temperature superconductivity, beginning at the time of publication of the Zeitschrift fur Physik paper by Bednorz and Muller. Phase 1 of the program was conceived by the Department of Science & Technology of the Government of India. It consisted of 42 projects in the area of basic research, 23 projects in applications and 4 short-term demonstration studies. The second phase started in October 1991 and will run through March 1995. It consists of 50 basic research programs and 24 application programs. The total investment, mainly consisting of infrastructural development to supplement existing facilities and hiring younger people, has amounted to about Indian Rupees 40 crores, equivalent to about US$ 13 million. The expenditure for the period 1992-1997 shall be up to about Rs. 27 crores, equivalent to about US$ 9 million. The basic idea is to keep pace with developments around the world.

  9. Excimer laser processing of inkjet-printed and sputter-deposited transparent conducting SnO{sub 2}:Sb for flexible electronics

    Energy Technology Data Exchange (ETDEWEB)

    Cranton, Wayne M. [School of Computing and Informatics, Nottingham Trent University, Nottingham, NG11 8NS (United Kingdom)], E-mail: wayne.cranton@ntu.ac.uk; Wilson, Sharron L.; Ranson, Robert; Koutsogeorgis, Demosthenes C. [School of Computing and Informatics, Nottingham Trent University, Nottingham, NG11 8NS (United Kingdom); Chi Kuangnan [Patterning Technologies Ltd., 58 Shrivenham Hundred Business Park, Watchfield, Oxon, SN6 8TY (United Kingdom)], E-mail: kuangnan.chi@pattech.com; Hedgley, Richard; Scott, John [Patterning Technologies Ltd., 58 Shrivenham Hundred Business Park, Watchfield, Oxon, SN6 8TY (United Kingdom); Lipiec, Stephen [Keeling and Walker Limited, Whieldon Road, Stoke-on-Trent, Staffordshire, ST4 4JA (United Kingdom)], E-mail: s.lipiec@keelingwalker.co.uk; Spiller, Andrew [Keeling and Walker Limited, Whieldon Road, Stoke-on-Trent, Staffordshire, ST4 4JA (United Kingdom); Speakman, Stuart [MDSL 7 Chapel Drive, Little Waltham, Chelmsford, Essex, CM3 3LW (United Kingdom)], E-mail: sps7859@btconnect.com

    2007-10-15

    The feasibility of low-temperature fabrication of transparent electrode elements from thin films of antimony-doped tin oxide (SnO{sub 2}:Sb, ATO) has been investigated via inkjet printing, rf magnetron sputtering and post-deposition excimer laser processing. Laser processing of thin films on both glass and plastic substrates was performed using a Lambda Physik 305i excimer laser, with fluences in the range 20-100 mJ cm{sup -2} reducing sheet resistance from as-deposited values by up to 3 orders of magnitude. This is consistent with TEM analysis of the films that shows a densification of the upper 200 nm of laser-processed regions.

  10. Time evolution of the high temperature region formed by laser induced breakdown and of the development of the flame kernel in the constant volume combustion vessel

    Science.gov (United States)

    Hayashi, J.; Nakatsuka, N.; Morimoto, I.; Akamatsu, F.

    2017-02-01

    The lean combustion is one of the key techniques for the advanced internal combustion systems due to the requirement of the higher thermal efficiency. Since the successful ignition must be guaranteed even in the lean combustion, advanced ignition systems have been developed in this decade. Laser ignition is one of the advanced ignition systems which have the profits of the flexibility in the position and the timing of ignition. To develop this ignition system for the actual combustion system, it is required to reveal the underlying physics of the laser ignition. Particularly, the time evolution of high temperature region formed by laser induced breakdown should be discussed. In this study, therefore, the time evolution of the high temperature region formed by the laser induced breakdown and the development of flame kernel were observed by using high-speed imaging. The ignition trials of methane/air lean premixed mixture were carried out in the constant volume combustion vessel to obtain minimum laser pulse energy for ignition (MPE). Results showed that the light emission from plasma formed by laser induced breakdown remained at least in several tens nano-seconds. In addition, there were large differences between the breakdown threshold and the MPE, which meant that the breakdown threshold did not determine the minimum pulse energy for ignition.

  11. A Comparative Study of Three Different Chemical Vapor Deposition Techniques of Carbon Nanotube Growth on Diamond Films

    Directory of Open Access Journals (Sweden)

    Betty T. Quinton

    2013-01-01

    Full Text Available This paper compares between the methods of growing carbon nanotubes (CNTs on diamond substrates and evaluates the quality of the CNTs and the interfacial strength. One potential application for these materials is a heat sink/spreader for high-power electronic devices. The CNTs and diamond substrates have a significantly higher specific thermal conductivity than traditional heat sink/spreader materials making them good replacement candidates. Only limited research has been performed on these CNT/diamond structures and their suitability of different growth methods. This study investigates three potential chemical vapor deposition (CVD techniques for growing CNTs on diamond: thermal CVD (T-CVD, microwave plasma-enhanced CVD (MPE-CVD, and floating catalyst thermal CVD (FCT-CVD. Scanning electron microscopy (SEM and high-resolution transmission electron microscopy (TEM were used to analyze the morphology and topology of the CNTs. Raman spectroscopy was used to assess the quality of the CNTs by determining the ID/IG peak intensity ratios. Additionally, the CNT/diamond samples were sonicated for qualitative comparisons of the durability of the CNT forests. T-CVD provided the largest diameter tubes, with catalysts residing mainly at the CNT/diamond interface. The MPE-CVD process yielded non uniform defective CNTs, and FCT-CVD resulted in the smallest diameter CNTs with catalyst particles imbedded throughout the length of the nanotubes.

  12. 0-π Transition Driven by Magnetic Proximity Effect in a Josephson Junction

    Science.gov (United States)

    Hikino, Shin-ichi; Yunoki, Seiji

    2015-02-01

    We theoretically study the Josephson effect in a superconductor/normal metal/superconductor (S/N/S) Josephson junction composed of s-wave Ss with N which is sandwiched by two ferromagnetic insulators (Fs), forming a spin valve, in the vertical direction of the junction. We show that the 0-π transition of the Josephson critical current occurs with increasing the thickness of N along the junction. This transition is due to the magnetic proximity effect (MPE) which induces ferromagnetic magnetization in the N. Moreover, we find that, even for fixed thickness of N, the proposed Josephson junction with the spin valve can be switched from π to 0 states and vice versa by varying the magnetization configuration (parallel or antiparallel) of two Fs. We also examine the effect of spin-orbit scattering on the Josephson critical current and argue that the 0-π transition found here can be experimentally observed within the current nanofabrication techniques, thus indicating a promising potential of this junction as a 0-π switching device operated reversibly with varying the magnetic configuration in the spin valve by, e.g., applying an external magnetic field. Our results not only provide possible applications in superconducting electronics but also suggest the importance of a fundamental concept of MPE in nanostructures of multilayer N/F systems.

  13. MICROS E PEQUENAS EMPRESAS NO BRASIL – UM OLHAR PARA SITUAÇÃO EM OSASCO E UMA CONTRIBUIÇÃO PARA O PROCESSO DE IMPLANTAÇÃO DO CÓDIGO DE ÉTICA

    Directory of Open Access Journals (Sweden)

    Maria Inês Zampolim Coelho

    2011-06-01

    Full Text Available The organic structure of Micro and Small Companies (MPE in Brazil is simpler than the one in medium and large companies, nevertheless they can present similar problems in its day-today, such as ethical misconduct of its administrators or owners, controllers’ or employees’ corruption, fiscal tax evasion, problems of relationships with customers and suppliers, among others conflicts. The main objective of this research is identifying the current situation of some of the smaller companies in the city of Osasco, focusing on the Code of Ethics. The research sample, made through phone calls, showed us that many of these companies do not have any code of ethics. This finding indicated the necessity for a bibliographical research and some statistical data to confirm the importance of the Ethic Code for the MPE. The results gave us the opportunity to contribute with steps for the implementation of an Ethic Code in Micro and Small companies, aiming an expansion of their market image and better competitiveness.

  14. A survey of the urban radiofrequency (RF) environment.

    Science.gov (United States)

    Tell, Richard A; Kavet, Robert

    2014-12-01

    In 1980, Tell and Mantiply published a study of radiofrequency (RF) fields measured across 15 major metropolitan areas in the USA. They required a van fully equipped with instrumentation and computing capability for their measurements. This study aimed to assess whether and how hand-held instrumentation available today would facilitate and enhance the efficiency of large-scale surveys of ambient RF fields. In addition, the data would provide a suggestion as to how the profile of ambient RF fields has changed with respect to frequency content and magnitude. Not unexpectedly, the relative power densities were orders of magnitude lower than the Federal Communications Commission's (FCC) maximum permissible exposure (MPE) for the general public, with a maximum time-averaged value across the VHF-FM-UHF-cellular bands of 0.12 % of the MPE (AM's contribution was negligible). In both the 1980 and the present study, the power density in the FM band was a major contributor to overall power density, but over time, power densities in the VHF and UHF band decreased and increased, respectively. From the perspective of absolute power density, the wideband values in the 1980 study, this study and any number of assessments conducted in European nations are not generally different from one another. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  15. Asymptotics of Bayesian Error Probability and Rotating-PSF-Based Source Super-Localization in Three Dimensions

    CERN Document Server

    Prasad, Sudhakar

    2014-01-01

    We present an asymptotic analysis of the minimum probability of error (MPE) in inferring the correct hypothesis in a Bayesian multi-hypothesis testing (MHT) formalism using many pixels of data that are corrupted by signal dependent shot noise, sensor read noise, and background illumination. We perform this error analysis for a variety of combined noise and background statistics, including a pseudo-Gaussian distribution that can be employed to treat approximately the photon-counting statistics of signal and background as well as purely Gaussian sensor read-out noise and more general, exponentially peaked distributions. We subsequently apply the MPE asymptotics to characterize the minimum conditions needed to localize a point source in three dimensions by means of a rotating-PSF imager and compare its performance with that of a conventional imager in the presence of background and sensor-noise fluctuations. In a separate paper, we apply the formalism to the related but qualitatively different problem of 2D supe...

  16. Laser sources in dentistry and radiation safety regulations

    Science.gov (United States)

    De Luca, D.; Gaeta, G. M.; Lepore, M.

    2007-02-01

    Nowadays laser sources are largely adopted in dentistry due to their unique properties making them good candidates to substitute traditional scalpel and conventional diamond bur in the surgery of the soft and hard oral tissue, respectively. The large use of laser sources outside the research laboratories without the need of highly specialized personnel can ask for a widespread knowledge of safety issues related to this kind of equipment. The main hazard of accidental exposures regards eyes injury but increasing the power of the laser beam also skin can be involved. Safety legislations in Europe and U.S.A. take into account non ionizing radiations and laser radiation for the hazards for the health deriving from physical agents. Laser safety standards introduce 3 useful parameters for hazard characterization: "Accessible Emission Limit" (AEL), "Maximum Permissible Exposure" (MPE) and "Nominal Ocular Hazard Distance" (NOHD). We measured the MPE and NOHD for Er:YAG and other laser sources currently adopted in dentistry and we compared our results with data elaborated from standards in order to single out safe and comfortable working conditions. In fact an experimental assessment of the hazard parameters and the comparison with those of reference from safety standards turns out to be useful in order to estimate the residual hazard that can be still present after applying all the engineering protection and administrative rules.

  17. News regarding Mobility at CERN

    CERN Multimedia

    2016-01-01

    CERN Bikes CERN owns a fleet of more than 500 bikes, managed by the Mobility Centre (bdg. 6167). Members of CERN personnel (MPE and MPA) can use these free of charge during work-related activities at CERN (a security deposit is requested). Between 1st of June to 30th September anyone, except Summer Students, who wish to benefit from this service shall pay 1 CHF per day. As from the 1st of August, the CERN bike rental requests are done via the Service Now (SNOW) Portal. For more information, please consult: http://cern.ch/bike-rental.   CERN Cars More than 60 vehicles are available for rent by members of personnel (MPE and MPA) at the Mobility Center (bdg. 6167). As from the 5th of September you can submit reservation requests via the new EDH Car Rental Request document. As a reminder, the Terms of Use are the following: Operational Circular n° 4 (rev.1), governing the use of CERN vehicles;   Any use of the service must be authorised by the concerned Head of Department or Team Leader...

  18. DETERMINING SMALL AND MEDIUM INDUSTRY MAIN PRODUCT IN BANYUMAS DISTRICT

    Directory of Open Access Journals (Sweden)

    Muhammad Unggul Abdul Fattah

    2016-01-01

    Full Text Available The purpose of this study was to determine the main product out of several alternative options of small and medium industries (IKM main product in Banyumas District. The study was conducted by using in-depth interviews with respondents who were skillful experts with the authority to establish the main product in Banyumas. The criteria used in determining the main product come from 12 criteria set out in the Regulation of the Ministry of Home Affairs of Republic of Indonesia Number 9 of 2014. The establishment of criteria values was determined by using AHP and main product assessment with MPE. The results of the assessment indicate that the first priority of main product Banyumas is the coconut sugar. Coconut sugar products are supported by the abundance of natural resources of raw materials, while the other main product priorities include mendoan tempeh and getuk gerbong which are typical products of Banyumas. Both products are products that will facilitate economic growth through tourism as a specific sector for culinary products of Banyumas.Keywords: main product, small and medium industries (IKM, AHP, MPE

  19. HPLC Evaluation of Phenolic Profile, Nutritive Content, and Antioxidant Capacity of Extracts Obtained from Punica granatum Fruit Peel

    Directory of Open Access Journals (Sweden)

    Sushil Kumar Middha

    2013-01-01

    Full Text Available This study revealed polyphenolic content, nutritive content, antioxidant activity, and phenolic profile of methanol and aqueous extracts of Punica granatum peel extract. For this, extracts were screened for possible antioxidant activities by free radical scavenging activity (DPPH, hydrogen peroxide scavenging activity and ferric-reducing antioxidant power (FRAP assays. The total phenolics and flavonoid recovered by methanolic (MPE and the water extract (AQPE were ranged from 185 ± 12.45 to 298.00 ± 24.86 mg GAE (gallic acid equivalents/gm and 23.05 ± 1.54 to 49.8 ± 2.14 quercetin (QE mg/g, respectively. The EC50 of herbal extracts ranged from 100 µg/ml (0.38 quercetin equivalents, for AQPE, 168 µg/ml (0.80 quercetin equivalents, for MPE. The phenolic profile in the methanolic extracts was investigated by chromatographic (HPLC method. About 5 different flavonoids, phenolic acids, and their derivatives including quercetin (1, rutin (2, gallic acid (3, ellagic acid (4, and punicalagin as a major ellagitannin (5 have been identified. Among both extracts, methanolic extract was the most effective. This report may be the first to show nutritive content and correlation analysis to suggest that phenols and flavonoids might contribute the high antioxidant activity of this fruit peel and establish it as a valuable natural antioxidant source applicable in the health food industry.

  20. AL-FEC for Improved Mobile Reception of MPEG-2 DVB-T Transport Streams

    Directory of Open Access Journals (Sweden)

    David Gozálvez

    2009-01-01

    Full Text Available We investigate the use of application layer FEC protection in DVB-T (Digital Video Broadcasting-Terrestrial networks for the provision of mobile services. Mobile reception is characterized by variations of the received signal caused by fast fading and shadowing. DVB-T was originally designed for fixed and portable reception, and generally does not provide enough quality in mobile environments. The link layer protection mechanism MPE-FEC (Multi Protocol Encapsulation-Forward Error Correction was standardized in DVB-H (Digital Video Broadcasting-Handheld for the protection of mobile TV services. Although DVB-T itself does not incorporate any link or application layer protection mechanism, AL-FEC (Application layer Forward Error Correction protection can be introduced in DVB-T in a backwards compatible way. By means of AL-FEC, it is possible to improve the robustness of DVB-T services for the provision of mobile TV. In this paper, we explain the concept of AL-FEC protection in DVB-T and evaluate its performance by means of laboratory measurements and dynamic simulations with shadowing. We study different configurations of AL-FEC and compare its performance with MPE-FEC. In this paper, we discuss some implementation aspects of AL-FEC in real scenarios and propose an implementation based on Raptor codes and hash sequences. We also present results obtained by a first AL-FEC prototype for DVB-T that demonstrates the feasibility of the approach.

  1. Comparison of Error Protection Methods for Audio-Video Broadcast over DVB-H

    Directory of Open Access Journals (Sweden)

    Satu Jumisko-Pyykkö

    2007-01-01

    Full Text Available The paper discusses methods for robust audio-video broadcast over the digital video broadcasting-handheld (DVB-H system. DVB-H includes a link-layer forward error correction (FEC scheme known as multiprotocol encapsulation (MPE FEC, which provides equal error protection (EEP to the transmitted media streams. Several approaches for unequal error protection (UEP have been proposed in the literature, and the applicability of some of them to DVB-H is analyzed in the paper. A link-layer UEP method based on priority segmentation of the media streams is chosen for more detailed analysis. According to the method, audio and the most important coded video pictures are protected by MPE-FEC more robustly compared to the remaining coded pictures. In order to compare EEP and UEP in a DVB-H environment, an error-prone DVB-H channel was simulated, audio-visual clips were sent through it, and a comprehensive subjective quality evaluation was conducted in a controlled laboratory environment. The results of the subjective evaluation revealed that the use of UEP improves the subjective quality of some test clips noticeably when the channel conditions were severe, while in other tested channel conditions and clips, UEP and EEP performed equally well.

  2. Comparison of Error Protection Methods for Audio-Video Broadcast over DVB-H

    Science.gov (United States)

    Hannuksela, Miska M.; Malamal Vadakital, Vinod Kumar; Jumisko-Pyykkö, Satu

    2007-12-01

    The paper discusses methods for robust audio-video broadcast over the digital video broadcasting-handheld (DVB-H) system. DVB-H includes a link-layer forward error correction (FEC) scheme known as multiprotocol encapsulation (MPE) FEC, which provides equal error protection (EEP) to the transmitted media streams. Several approaches for unequal error protection (UEP) have been proposed in the literature, and the applicability of some of them to DVB-H is analyzed in the paper. A link-layer UEP method based on priority segmentation of the media streams is chosen for more detailed analysis. According to the method, audio and the most important coded video pictures are protected by MPE-FEC more robustly compared to the remaining coded pictures. In order to compare EEP and UEP in a DVB-H environment, an error-prone DVB-H channel was simulated, audio-visual clips were sent through it, and a comprehensive subjective quality evaluation was conducted in a controlled laboratory environment. The results of the subjective evaluation revealed that the use of UEP improves the subjective quality of some test clips noticeably when the channel conditions were severe, while in other tested channel conditions and clips, UEP and EEP performed equally well.

  3. Detection of EpCAM-positive microparticles in pleural fluid: A new approach to mini-invasively identify patients with malignant pleural effusions

    Science.gov (United States)

    Roca, Elisa; Lacroix, Romaric; Judicone, Coralie; Laroumagne, Sophie; Robert, Stéphane; Cointe, Sylvie; Muller, Alexandre; Kaspi, Elise; Roll, Patrice; Brisson, Alain R.; Tantucci, Claudio

    2016-01-01

    Pleural biomarkers allowing to mini-invasively discriminate benign from malignant pleural effusions are needed. Among potential candidates, microparticles (MPs) are extracellular vesicles that vectorize antigen derived from the parent cell. We hypothesized that tumor-derived MPs could be present in the pleural liquid and help to identify patients with malignant pleural effusions. Using highly sensitive flow cytometry and cryo-electron microscopy, we showed that large amounts of MPs from hematopoïetic and vascular origin could be detectable in pleural fluids. Their level did not differ between benign (n = 14) and malignant (n = 71) pleural effusions. Analysis of selected tumoral associated antigens (podoplanin, mucin 1 and EpCAM, epithelial-cell-adhesion-molecule) evidenced for the first time the presence of tumor-derived MPs expressing EpCAM in malignant pleural fluids only (Specificity = 93%, Sensitivity = 49% and 45% for flow cytometry and ELISA, respectively). The detection of EpCAM-positive-MPs (EpCAM + MPs) by flow cytometry showed a better specificity and sensitivity than ELISA to distinguish between pleural carcinoma and the others malignant pleural effusions (MPE; Sp: 96% vs 89%; Se: 79% vs 66%). Combining EpCAM+ MPs and cytology improved the diagnosis of MPE compared to cytology alone. This study establishes the basis for using EpCAM+ MPs as a promising new biomarker that could be added to the armamentarium to mini-invasively identify patients with malignant pleural effusions. PMID:26689993

  4. Sensitivity of Distributed Hydrologic Simulations to Ground and Satellite Based Rainfall Products

    Directory of Open Access Journals (Sweden)

    Singaiah Chintalapudi

    2014-05-01

    Full Text Available In this study, seven precipitation products (rain gauges, NEXRAD MPE, PERSIANN 0.25 degree, PERSIANN CCS-3hr, PERSIANN CCS-1hr, TRMM 3B42V7, and CMORPH were used to force a physically-based distributed hydrologic model. The model was driven by these products to simulate the hydrologic response of a 1232 km2 watershed in the Guadalupe River basin, Texas. Storm events in 2007 were used to analyze the precipitation products. Comparison with rain gauge observations reveals that there were significant biases in the satellite rainfall products and large variations in the estimated amounts. The radar basin average precipitation compared very well with the rain gauge product while the gauge-adjusted TRMM 3B42V7 precipitation compared best with observed rainfall among all satellite precipitation products. The NEXRAD MPE simulated streamflows matched the observed ones the best yielding the highest Nash-Sutcliffe Efficiency correlation coefficient values for both the July and August 2007 events. Simulations driven by TRMM 3B42V7 matched the observed streamflow better than other satellite products for both events. The PERSIANN coarse resolution product yielded better runoff results than the higher resolution product. The study reveals that satellite rainfall products are viable alternatives when rain gauge or ground radar observations are sparse or non-existent.

  5. Physically-based Flood Modeling Driven by Radar Rainfall in the Upper Guadalupe River Basin, Texas

    Science.gov (United States)

    Sharif, H. O.; Chintalapudi, S.; El Hassan, A.

    2011-12-01

    The upstream portion of the Guadalupe River Basin (Upper Guadalupe River Basin) is prone to frequent flooding due to its physiographic properties (thin soils, exposed bedrock, and sparse vegetation). The Upper Guadalupe River watershed above Comfort, Texas drains an area of 2,170 square kilometers. This watershed is located at the central part of the Texas Hill Country. This study presents hydrologic analysis of the June 2002, November-2004, and August-2007 flood events that occurred in Upper Guadalupe River Basin. The physically based, distributed-parameter Gridded Surface Subsurface Hydrologic Analysis (GSSHA) hydrologic model was used to simulate the above flooding events. The first event was used in model while the other two were used for validation. GSSHA model was driven by both rain gauge and Multi-sensor Precipitation Estimator (MPE) rainfall inputs. Differences in simulation results were compared in terms of the hydrographs at different locations in the basin as well as the spatial distribution of hydrologic processes. GSSHA simulations driven by MPE rainfall match very well the USGS observed hydrograph. GSSHA simulation driven by rain gauge rainfall for June-2002 storm event underestimated the peak flow.

  6. Using Akka Platform in Unidentified Falling Object Detection on the LHC.

    CERN Document Server

    Motesnitsalis, Evangelos

    2013-01-01

    During my participation in the CERN Summer Student Program 2013, I worked under the Technology Department of CERN and, more specifically, in the Machine Protection and Electrical Integrity (MPE) Group. The MPE Group supports LHC operation and maintains state‐of‐the art technology for magnet circuit protection and interlock systems for the present and future accelerators, magnet test facilities and CERN hosted experiments. Within this context, we developed an application that parallelizes the Unidentified Falling Object Detection Algorithm on the LHC Operational Data Analysis Software. For this reason, we used a JVM-based toolkit, named Akka, which parallelizes the execution by creating a number of actors that run simultaneously. The results of the new approach are presented on the last part of this report. They tend to be quite interesting and promising as we managed to reduce the execution time of the analysis by a factor of 10 on a local machine and the first attempts to execute the program on a cluster...

  7. Valuación de opciones simples y complejas contenidas en arrendamientos financieros

    Directory of Open Access Journals (Sweden)

    Gastón Silverio Milanesi

    2016-01-01

    Full Text Available El valor de los contratos de arrendamiento es una función del valor presente de los cánones más las opciones reales operativas. Sin embargo, el método del préstamo equivalente (MPE, con amplia aplicación en la valuación de arrendamientos, falla porque no incorpora las opciones contenidas en el contrato. De esta forma, el presente trabajo propone un modelo de valuación combinando el MPE y el enfoque binomial para valuar opciones reales. Para lograr lo anterior, se realiza el planteamiento matemático y su aplicación para opciones simples (compra, cancelación anticipada, renovación y compuestas (venture leasing, leasing a porcentaje, pago diferido, pago diferido y compra, demostrando la habilidad del modelo para calcular el valor actual expandido del contrato, como la suma del valor actual de pagos y opciones operativas.

  8. Does Metal Transfer Differ on Retrieved Ceramic and CoCr Femoral Heads?

    Directory of Open Access Journals (Sweden)

    Eliza K. Fredette

    2015-01-01

    Full Text Available Metal transfer has been observed on retrieved THA femoral heads for both CoCr and ceramic bearing materials. In vitro wear testing has shown increased wear to polyethylene acetabular liners with the presence of metal transfer. This study sought to investigate the extent of metal transfer on the bearing surface of CoCr and ceramic femoral heads and identify prevalent morphologies. Three bearing couple cohorts: M-PE (n=50, C-PE (n=35, and C-C (n=15, were derived from two previously matched collections (n=50/group of CoCr and ceramic femoral heads. From the three cohorts, 75% of the femoral heads showed visual evidence of metal transfer. These femoral heads were analyzed using direct measurement, digital photogrammetry, and white light interferometry. Surface area coverage and curved median surface area were similar among the three cohorts. The most prevalent metal transfer patterns observed were random stripes (n=21/75, longitudinal stripes (n=17/75, and random patches (n=13/75. Metal transfer arc length was shorter in the M-PE cohort. Understanding the morphology of metal transfer may be useful for more realistic recreation of metal transfer in in vitro pin-on-disk and joint simulators studies.

  9. Development of a Novel, Low-Cost, Disposable Wooden Pencil Graphite Electrode for Use in the Determination of Antioxidants and Other Biological Compounds.

    Science.gov (United States)

    Kariuki, James; Ervin, Emily; Olafson, Carly

    2015-07-31

    The development of portable sensors that can be used outside the lab is an active area of research in the electroanalytical field. A major focus of such research is the development of low-cost electrodes for use in these sensors. Current electrodes, such as glassy-carbon electrodes (GCEs), are costly and require time-consuming preparation. Alternatives have been proposed, including mechanical pencil-lead electrodes (MPEs). However, MPEs themselves possess numerous drawbacks, particularly structural fragility. In this paper, we present a novel pencil-graphite electrode (PGE) fabricated from a regular HB#2 pencil. This PGE is a simple, disposable, extremely low-cost alternative to GCEs ($0.30 per PGE, vs. $190 + per GCE), and possesses the structural stability that MPEs lack. PGEs were characterized by square-wave voltammetry of ferricyanide, gallic acid, uric acid, dopamine, and several foodstuffs. In all cases, PGEs demonstrated sensitivities comparable or superior to those of the GCE and MPE (LOD = 5.62 × 10(-4) M PGE, 4.80 × 10(-4) M GCE, 2.93 × 10(-4) M MPE). Signal areas and peak heights were typically four to ten times larger for the PGE relative to the GCE.

  10. Elections for representatives of the personnel – Join, get involved, vote!

    CERN Multimedia

    Staff Association

    2017-01-01

    Every two years in September, the CERN Staff Association organises the elections of representatives of the personnel. The process of renewing the Staff Council consists of several stages: Information for members of the personnel (MPE and MPA1); call for applications and search for candidates in different electoral colleges; election of delegates via electronic voting; announcement of the results and establishing a new Staff Council. This process will follow a specific timetable: Call for applications from Monday, 11 September to Friday, 13 October at 5 p.m. Voting from Monday, 23 October at noon to Monday 13, November at 5 p.m. Publication of the election results in the Echo newsletter on Tuesdays 21 November and 5 December. Staff Association Assizes (for the outgoing Council and the new Council) on Monday, 27 and Tuesday, 28 November. First meeting of the new Staff Council and election of a new Executive Committee on Tuesday, 5 December. Informing the personnel (MPE and MPA) The Staff Association uses s...

  11. Functional petit-suisse cheese: measure of the prebiotic effect.

    Science.gov (United States)

    Cardarelli, Haíssa R; Saad, Susana M I; Gibson, Glenn R; Vulevic, Jelena

    2007-01-01

    Prebiotics and probiotics are increasingly being used to produce potentially synbiotic foods, particularly through dairy products as vehicles. It is well known that both ingredients may offer benefits to improve the host health. This research aimed to evaluate the prebiotic potential of novel petit-suisse cheeses using an in vitro fermentation model. Five petit-suisse cheese formulations combining candidate prebiotics (inulin, oligofructose, honey) and probiotics (Lactobacillus acidophilus, Bifidobacterium lactis) were tested in vitro using sterile, stirred, batch culture fermentations with human faecal slurry. Measurement of prebiotic effect (MPE) values were generated comparing bacterial changes through determination of maximum growth rates of groups, rate of substrate assimilation and production of lactate and short chain fatty acids. Fastest fermentation and high lactic acid production, promoting increased growth rates of bifidobacteria and lactobacilli, were achieved with addition of prebiotics to a probiotic cheese (made using starter+probiotics). Addition of probiotic strains to control cheese (made using just a starter culture) also resulted in high lactic acid production. Highest MPE values were obtained with addition of prebiotics to a probiotic cheese, followed by addition of prebiotics and/or probiotics to a control cheese. Under the in vitro conditions used, cheese made with the combination of different prebiotics and probiotics resulted in the most promising functional petit-suisse cheese. The study allowed comparison of potentially functional petit-suisse cheeses and screening of preferred synbiotic potential for future market use.

  12. Time-Division Multiuser MIMO with Statistical Feedback

    Directory of Open Access Journals (Sweden)

    Jia Chen

    2008-02-01

    Full Text Available This paper investigates a time-division multiuser multiple-input multiple-output (MIMO antenna system in K-block flat fading where users are given individual outage rate probability constraints and only one user accesses the channel at any given time slot (or block. Assuming a downlink channel and that the transmitter knows only the statistical information about the channel, our aim is to minimize the overall transmit power for achieving the users' outage constraint by jointly optimizing the power allocation and the time-sharing (i.e., the number of time slots of the users. This paper first derives the so-called minimum power equation (MPE to solve for the minimum transmit power required for attaining a given outage rate probability of a single-user MIMO block-fading channel if the number of blocks is predetermined. We then construct a convex optimization problem, which can mimic the original problem structure and permits to jointly consider the power consumption and the probability constraints of the users, to give a suboptimal multiuser time-sharing solution. This is finally combined with the MPE to provide a joint power allocation and time-sharing solution for the time-division multiuser MIMO system. Numerical results demonstrate that the proposed scheme performs nearly the same as the global optimum with inappreciable difference.

  13. Interdisciplinary education to integrate pathology and epidemiology: towards molecular and population-level health science.

    Science.gov (United States)

    Ogino, Shuji; King, Emily E; Beck, Andrew H; Sherman, Mark E; Milner, Danny A; Giovannucci, Edward

    2012-10-15

    In recent decades, epidemiology, public health, and medical sciences have been increasingly compartmentalized into narrower disciplines. The authors recognize the value of integration of divergent scientific fields in order to create new methods, concepts, paradigms, and knowledge. Herein they describe the recent emergence of molecular pathological epidemiology (MPE), which represents an integration of population and molecular biologic science to gain insights into the etiologies, pathogenesis, evolution, and outcomes of complex multifactorial diseases. Most human diseases, including common cancers (such as breast, lung, prostate, and colorectal cancers, leukemia, and lymphoma) and other chronic diseases (such as diabetes mellitus, cardiovascular diseases, hypertension, autoimmune diseases, psychiatric diseases, and some infectious diseases), are caused by alterations in the genome, epigenome, transcriptome, proteome, metabolome, microbiome, and interactome of all of the above components. In this era of personalized medicine and personalized prevention, we need integrated science (such as MPE) which can decipher diseases at the molecular, genetic, cellular, and population levels simultaneously. The authors believe that convergence and integration of multiple disciplines should be commonplace in research and education. We need to be open-minded and flexible in designing integrated education curricula and training programs for future students, clinicians, practitioners, and investigators.

  14. EUTEMPE-RX, an EC supported FP7 project for the training and education of medical physics experts in radiology.

    Science.gov (United States)

    Bosmans, H; Bliznakova, K; Padovani, R; Christofides, S; Van Peteghem, N; Tsapaki, V; Caruana, C J; Vassileva, J

    2015-07-01

    The core activity of the medical physics expert (MPE) is to ensure optimal use of ionising radiation in healthcare. It is essential that these healthcare professionals are trained to the highest level, defined as European Qualifications Framework for Lifelong Learning (EQF) level 8 by the European Commission's Radiation Protection Report 174 'Guidelines on the MPE'. The main objective of the EUTEMPE-RX project is to provide a model training scheme that allows the medical physicist in diagnostic and interventional radiology (D&IR) to reach this high level. A European network of partners was brought together in this FP7 EC project to ensure sufficient expertise in all aspects of the subject and to create a harmonised course programme. Targeted participants are medical physicists in D&IR in hospitals, engineers and scientists in medical device industries and officers working in regulatory authorities. Twelve course modules will be developed at EQF level 8, with radiation safety and diagnostic effectiveness being prevalent subjects. The modules will combine online with face-to-face teaching using a blended learning approach.

  15. The Effect of Silver Nitrate Pleurodesis after a Failed Thoracoscopic Talc Poudrage

    Directory of Open Access Journals (Sweden)

    Cecilia Menna

    2013-01-01

    Full Text Available Background. Chemical pleurodesis is the procedure of choice in the management of recurrent malignant pleural effusions (MPE. Talc is probably the most effective sclerosant, with a success rate of 80%. The aim of this study is to demonstrate the effectiveness of silver nitrate solution (SNS pleurodesis after an unsuccessful thoracoscopic talc poudrage. Methods. Between 2011 and 2013 one hundred and nine patients with unilateral MPE underwent thoracoscopic talc poudrage. Seventeen patients who did not obtain a successful pleurodesis via thoracoscopic procedure were considered for an SNS slurry. The pleural injectate consisted of 100 mL 1% SNS with 10 mL of lidocaine (100 mg/5 mL. The SNS procedure was undertaken once and repeated with the same dose in 5 patients. Results. The duration of follow-up period was 30 days. Subjective pain was low and the same before and after SNS procedure ( value = NS. The mean daily fluid drainage was statistically different ( comparing values before ( mL and after SNS procedure ( mL. After 30 days from SNS procedure recurrence of pleural effusion was observed in 2 patients (11%. Conclusions. The present study demonstrates that SNS is an effective agent for producing pleurodesis after a failed thoracoscopic talc poudrage.

  16. Clinical analysis of 80 cases of tuberculous pleural effusion and 39 cases malignant pleural effusion%80例结核性及39例恶性胸腔积液的临床分析

    Institute of Scientific and Technical Information of China (English)

    骆文志; 刘升明; 吴义

    2012-01-01

    Aim; Retrospective analysis on clinical manifestation and laboratory test results of tubercu-lous pleural effusion (TBPE) and malignant pleural effusion (MPE) , to probe into the value about the dif-ferent diagnosis of TBPE and MPE. Methods; Eighty hospitalized patients with TBPE or MPE were ana-lyzed retrospectively, particularly the content of CEA, LDH and ADA, which is for getting a better under-standing of TBPE and MPE and improving the ability of differential diagnosis. Results; ①The PLDH lev-els and the PLDH/SLDH ratio were no significant difference in two groups (P >0. 05). ② The differences of the PADA levels,the SADA levels and the PADA/SADA ratios were statistically significant( P <0.05). ③ After making use of multivariable logistic regression analysis, The valuable factors are onset age,fever, color of pleural effussion and the PADA/SADA ratio. Conclusion: ① The content of PADA and SADA were important basis for different diagnosing TBPE and MPE. The PADA is about 40 U/L, which is lower than 45 U/L, that as diagnostic standard is generally adopted; Regarding PADA/SADA = 1 as a liability standard, TBPE is greater than 1, MPE is fewer than 1, which is still need more discussion and the virtual PADA/SADA = (3. 44 ± 1. 38), but the ratio is bigger and more beneficial to TBPE. ②The logistic regression analysis shows putting onset age, fever, color of pleural effussion, ratios of PADA/SADA together for different diagnosis of TBPE and MPE has superior correctness.%目的:回顾性分析结核性和恶性胸腔积液的临床表现和实验室检查结果,探讨其对结核性和恶性胸腔积液鉴别诊断的价值.方法:收集80例结核性胸腔积液患者和39例恶性胸腔积液患者的病例资料,重点对癌胚抗原(CEA)、乳酸脱氢酶(LDH)、腺苷脱氨酶(ADA)测定结果进行统计学分析,为进一步提高对结核性和恶性胸腔积液的认识和更好地鉴别诊断提供依据.结果:①两组

  17. 氧化低密度脂蛋白及其受体与子痫前期发病的关系%Correlation of oxidized low-density lipoprotein and lectin-like oxidized low-density lipoprotein receptor-1 with pre-eclampsia

    Institute of Scientific and Technical Information of China (English)

    张妍; 叶元华; 彭伟; 詹瑛

    2009-01-01

    Objective To investigate the role of oxidized low-density lipoprotein (oxLDL) and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-I) in pre-ecalmpsia. Methods From June 2007 to January 2008,73 women with pre-eelampsia who delivered in the Department of Obstetrics, Affiliated Hospital of Qingdao University Medical College,were recruited, including 35 women with mild pre-eclampsia (MPE group) and 38 women with severe pre-eclampsia(SPE group). And 45 healthy pregnant women were taken as control group. Enzyme-linked immunosorbent assay (ELISA) was used to measure the plasma concentrations of oxLDL in these women. Semiquantitative RT-PCR and Western blot were used to investigate the expression of LOX-1 mRNA and protein in placenta. The expression of caspase-3 mRNA in placenta was determined using Semiquantitative RT-PCR. Results (1) The plasma concentrations of oxLDL in MPE group ( 0.42 ± 0.11 ) mg/L, SPE group ( 0.68 ± 0.12 ) mg/L, were significantly higher compared with control group (0.35 ± 0.14 )mg/L( P < 0.01 ) and the concentrations of oxLDL in MPE group were significantly higher compared with SPE group (P<0.01 ). (2) The expression of LOX-1 mRNA in placenta of MPE group(0.70 ±0.10) and SPE group(0.84 ±0.08) were significantly higher than that in control group(0.58 ± 0.11 ) ( P<0.01 ) and the expression of LOX-1 mRNA in MPE group was significantly higher than that of SPE group (P<0.01 ). (3) The expression of LOX-1 protein in placenta of MPE group (0.79±0.15 )and SPE group(0.90±0.12) were significantly higher compared with control group(0.68 ±0.11)( P<0.01 ), while the expression of LOX-1 protein of MPE group was significantly higher compared with SPE group (P <0.01 ). (4) The expression of caspase-3 mRNA in placenta of MPE group(3.82± 0.18) and SPE group(5.39±0.14) were significantly higher than that in control group(2.19±0.20) (P <0.01 ), and the expression of caspase-3 mRNA in MPE group was significantly higher than that of SPE group (P

  18. Microgranular enclaves in island-arc andesites: A possible link between known epithermal Au and potential porphyry Cu-Au deposits in the Tulasu ore cluster, western Tianshan, Xinjiang, China

    Science.gov (United States)

    Zhao, Xiaobo; Xue, Chunji; Symons, David T. A.; Zhang, Zhaochong; Wang, Honggang

    2014-05-01

    The successful exploration for porphyry copper deposit in western Tianshan, Xinjiang, faces great challenge. Tulasu basin is an important epithermal gold ore cluster in western Tianshan, which was formed in a southwest-Pacific-type island-arc setting during the late Paleozoic by the southward subduction of the North Tianshan ocean beneath the Yili plate. Porphyry Cu-Au deposits are possibly to be found at depth or adjacent to these epithermal gold deposits. Some sulfide-mineralized microgranular enclaves of monzonite porphyry and microdiorite were found in andesites of the Tawuerbieke gold district, Tulasu basin. The enclaves are randomly distributed, with generally round or subangular shape and commonly clearly defined within their host andesite, and have a chilled surrounding margin of andesite. The monzonite porphyry enclaves (MPE) exhibit porphyritic texture with the phenocrysts of plagioclase and K-feldspar. The microdiorite enclaves (MDE) are mainly composed of plagioclase and hornblende with an aplitic texture and massive structure. The host andesites show porphyritic texture, with the phenocrysts major of plagioclase, minor of hornblende and clinopyroxene. The groundmass consists of short-column plagioclase and minor clinopyroxene with a hyalopilitic texture. Zircon grains from a MPE sample yield a weighted 206Pb/238U age of 356.2 ± 4.3 Ma (n = 13, MSWD = 1.11), which is effectively coincident with the 360.5 ± 3.4 Ma (n = 20, MSWD = 0.61) of an andesite sample within analytical error, indicating that they were coeval. In addition, the MPE, MDE and the andesite samples share similar normalized incompatible element and rare earth element patterns that are characterized by a pronounced enrichment of large ion lithophile elements and a deficit of high field strength elements. Moreover, the samples show similar Nd isotope compositions to the contemporary andesites and basaltic andesites. Detailed petrology, geochronology and geochemistry studies suggest that

  19. Research on automatic inclination detection and weighting error compensation methods of electronic scale%电子秤倾角自动检测与称量误差补偿方法研究

    Institute of Scientific and Technical Information of China (English)

    唐立军; 滕召胜; 陈良柱; 刘海仓

    2011-01-01

    针对传统电子秤水平调节繁琐,存在倾角时称重准确度低等不足,设计了一种具有倾角自动检测与称量误差补偿功能的高精度电子秤.分析了秤台倾角对电子秤称量性能的影响,介绍了基于三轴加速度传感器ADXL345的倾角检测和称量误差补偿原理,提出并建立了电子秤倾角自动补偿模型,给出了基于微处理器ADuC7060的倾角测量系统的软、硬件设计与实现方案.对量程为1 000 g、感量为0.01 g的电子秤倾角补偿后进行的测试结果表明,在倾角小于1°时,仪器的最大允许误差MPE<0.05 g; 当倾角小于15(时,最大允许误差MPE<0.2 g.%Confronted with the inconvenient leveling operation and the low accuracy in traditional electronic scale, a highly accurate electronic scale with automatic inclination detection and weighting error compensation is designed. In this paper, the effect of inclination on the weighting accuracy is analyzed, the principles of automatic inclination detection and weighting error compensation using three-axis digital accelerometer ADXL345 is introduced, an automatic inclination compensation model is hereby developed. Furthermore, the software and hardware solution to the inclination detecting system based on microprocessor ADuC7060 are also presented. Experimental results how that the maximum permissible error (MPE) is respectively less than 0.05 g and 0.2 g when the inclination angle is less than 1° or 15°, with the weighing range of 1 000 g the discrimination of 0.01 g.

  20. Effect of patent ductus arteriosus and patent foramen ovale on left ventricular stroke volume measurement by electrical velocimetry in comparison to transthoracic echocardiography in neonates.

    Science.gov (United States)

    Blohm, Martin Ernst; Hartwich, Jana; Obrecht, Denise; Kersten, Jan Felix; Singer, Dominique

    2017-06-01

    This prospective single-center observational study compared impedance cardiography [electrical velocimetry (EV)] with transthoracic echocardiography (TTE, based on trans-aortic flow) and analyzed the influence of physiological shunts, such as patent ductus arteriosus (PDA) or patent foramen ovale (PFO), on measurement accuracy. Two hundred and ninety-one triplicate simultaneous paired left ventricular stroke volume (LVSV) measurements by EV (LVSVEV) and TTE (LVSVTTE) in 99 spontaneously breathing neonates (mean weight 3270 g; range 1227-4600 g) were included. For the whole cohort, the mean absolute LVSVEV was 5.5 mL, mean LVSVTTE was 4.9 mL, resulting in an absolute Bland-Altman bias of -0.7 mL (limits of agreement LOA -3.0 to 1.7 mL), relative bias -12.8 %; mean percentage error MPE 44.9 %; true precision TPEV 33.4 % (n = 99 aggregated data points). In neonates without shunts (n = 32): mean LVSVEV 5.0 mL, mean LVSVTTE 4.6 mL, Bland-Altman bias -0.4 mL (LOA -2.8 to 2.0 mL), relative bias -8.2 %; MPE 50.7 %; TPEV 40.9 %. In neonates with shunts (PDA and/or PFO; n = 67): mean LVSVEV 5.8 mL, mean LVSVTTE 5.0 mL, bias -0.8 mL (LOA -3.1 to 1.5 mL), relative bias -14.8 %, MPE 41.9 %, TPEV 29.3 %. Accuracy was affected by PDA and/or PFO, with a significant increase in the relative difference in LVSVEV versus LVSVTTE: Subjects without shunts -2.9 % (n = 91), PFO alone -9.6 % (n = 125), PDA alone -14.0 % (n = 12), and PDA and PFO -18.5 % (n = 63). Physiological shunts (PDA and/or PFO) in neonates affect measurement accuracy and cause overestimation of LVSVEV compared with LVSVTTE.

  1. Assessing genotypic variability of cowpea (Vigna unguiculata [L.] Walp.) to current and projected ultraviolet-B radiation.

    Science.gov (United States)

    Singh, Shardendu K; Surabhi, Giridara-Kumar; Gao, W; Reddy, K Raja

    2008-11-13

    The current and projected terrestrial ultraviolet-B (UV-B) radiation affects growth and reproductive potential of many crops. Cowpea (Vigna unguiculata [L.] Walp.), mostly grown in tropical and sub-tropical regions may already be experiencing critical doses of UV-B radiation due to a thinner ozone column in those regions. Better understanding of genotypic variability to UV-B radiation is a prerequisite in developing genotypes tolerant to current and projected changes in UV-B radiation. An experiment was conducted in sunlit, controlled environment chambers to evaluate the sensitivity of cowpea genotypes to a range of UV-B radiation levels. Six cowpea genotypes [Prima, California Blackeye (CB)-5, CB-27, CB-46, Mississippi Pinkeye (MPE) and UCR-193], representing origin of different geographical locations, were grown at 30/22 degrees C day/night temperature from seeding to maturity. Four biologically effective ultraviolet-B radiation treatments of 0 (control), 5, 10, and 15 kJ m(-2)d(-1) were imposed from eight days after emergence to maturity. Significant genotypic variability was observed for UV-B responsiveness of eighteen plant attributes measured. The magnitude of the sensitivity to UV-B radiation also varied among cowpea genotypes. Plants from all genotypes grown in elevated UV-B radiation were significantly shorter in stem and flower lengths and exhibited lower seed yields compared to the plants grown under control conditions. Most of the vegetative parameters, in general, showed a positive response to UV-B, whereas the reproductive parameters exhibited a negative response showing the importance of reproductive characters in determining tolerance of cultivars to UV-B radiation. However, all cultivars, except MPE, behaved negatively to UV-B when a combined response index was derived across parameters and UV-B levels. Based on the combined total stress response index (C-TSRI) calculated as sum of individual vegetative, physiological and reproductive component

  2. Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM197 carriers.

    Science.gov (United States)

    Jalah, Rashmi; Torres, Oscar B; Mayorov, Alexander V; Li, Fuying; Antoline, Joshua F G; Jacobson, Arthur E; Rice, Kenner C; Deschamps, Jeffrey R; Beck, Zoltan; Alving, Carl R; Matyas, Gary R

    2015-06-17

    Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effects of the drug by sequestering the drug in the blood and preventing it from crossing the blood-brain barrier. Drugs of abuse are too small to induce antibodies and, therefore, require conjugation of drug hapten analogs to a carrier protein. The efficacy of these conjugate vaccines depends on several factors including hapten design, coupling strategy, hapten density, carrier protein selection, and vaccine adjuvant. Previously, we have shown that 1 (MorHap), a heroin/morphine hapten, conjugated to tetanus toxoid (TT) and mixed with liposomes containing monophosphoryl lipid A [L(MPLA)] as adjuvant, partially blocked the antinociceptive effects of heroin in mice. Herein, we extended those findings, demonstrating greatly improved vaccine induced antinociceptive effects up to 3% mean maximal potential effect (%MPE). This was obtained by evaluating the effects of vaccine efficacy of hapten 1 vaccine conjugates with varying hapten densities using two different commonly used carrier proteins, TT and cross-reactive material 197 (CRM197). Immunization of mice with these conjugates mixed with L(MPLA) induced very high anti-1 IgG peak levels of 400-1500 μg/mL that bound to both heroin and its metabolites, 6-acetylmorphine and morphine. Except for the lowest hapten density for each carrier, the antibody titers and affinity were independent of hapten density. The TT carrier based vaccines induced long-lived inhibition of heroin-induced antinociception that correlated with increasing hapten density. The best formulation contained TT with the highest hapten density of ≥30 haptens/TT molecule and induced %MPE of approximately 3% after heroin challenge. In contrast, the best formulation using CRM197 was with intermediate 1 densities (10-15 haptens/CRM197 molecule), but the %MPE was approximately 13%. In addition, the chemical synthesis of 1, the optimization of the conjugation

  3. The large conductance Ca2+ -activated K+ (BKCa channel regulates cell proliferation in SH-SY5Y neuroblastoma cells by activating the staurosporine-sensitive protein kinases

    Directory of Open Access Journals (Sweden)

    Angela eCurci

    2014-12-01

    Full Text Available Here we investigated on the role of the calcium activated K+-channels(BKCa on the regulation of the neuronal viability. Recordings of the K+-channel current were performed using patch-clamp technique in human neuroblastoma cells (SH-SY5Y in parallel with measurements of the cell viability in the absence or presence of the BKCa channel blockers iberiotoxin(IbTX and tetraethylammonium (TEA and the BKCa channel opener NS1619. Protein kinase C/A (PKC, PKA activities in the cell lysate were investigated in the presence/absence of drugs. The whole-cell K+-current showed a slope conductance calculated at negative membrane potentials of 126.3 pS and 1.717 nS(n = 46 following depolarization. The intercept of the I/V curve was -33 mV. IbTX(10-8-4x10-7M reduced the K+-current at +30 mV with an IC50 of 1.85x10-7M and an Imax of -46%(slope=2.198(n =21. NS1619(10-100x10-6M enhanced the K+-current of +141%(n =6, at -10 mV(Vm. TEA(10-5-10-3M reduced the K+-current with an IC50 of 3.54x10-5M and an Imax of -90%(slope=0.95(n =5. A concentration-dependent increase of cell proliferation was observed with TEA showing a maximal proliferative effect(MPE of +38% (10-4M. IbTX showed an MPE of +42% at 10-8M concentration, reducing it at higher concentrations. The MPE of the NS1619(100x10-6M was +42%. The PKC inhibitor staurosporine (0.2-2x10-6M antagonized the proliferative actions of IbTX and TEA. IbTX (10x10-9M, TEA (100x10-6M and the NS1619 significantly enhanced the PKC and PKA activities in the cell lysate with respect to the controls. These results suggest that BKCa channel regulates proliferation of the SH-SY5Y cells through PKC and PKA protein kinases.

  4. Home composting as an alternative treatment option for organic household waste in Denmark: An environmental assessment using life cycle assessment-modelling

    DEFF Research Database (Denmark)

    Andersen, J.K.; Boldrin, Alessio; Christensen, Thomas Højlund

    2012-01-01

    An environmental assessment of the management of organic household waste (OHW) was performed from a life cycle perspective by means of the waste-life cycle assessment (LCA) model EASEWASTE. The focus was on home composting of OHW in Denmark and six different home composting units (with different....... The GHG emissions were, on the other hand, dependent on the management of the composting units. The frequently mixed composting units had the highest GHG emissions. The environmental profiles of the home composting scenarios were in the order of −2 to 16 milli person equivalents (mPE) Mg−1 wet waste (ww...... input and different mixing frequencies) were modelled. In addition, incineration and landfilling was modelled as alternatives to home composting. The most important processes contributing to the environmental impact of home composting were identified as greenhouse gas (GHG) emissions (load...

  5. Shaw Prize Goes to Reinhard Genzel

    Science.gov (United States)

    2008-06-01

    The Shaw Prize in Astronomy for 2008 is awarded to Professor Reinhard Genzel, Director of the Max Planck Institute for Extraterrestrial Physics (MPE), in recognition of his outstanding contribution in demonstrating that the Milky Way contains a supermassive black hole at its centre, a result largely obtained with the help of ESO's telescopes. Black Hole ESO PR Photo 18/08 Motion of a Star The Shaw Prize is awarded annually by the Shaw Prize Foundation in Hong Kong in the Life Sciences, Mathematical Sciences and Astronomy, each of the three prizes bearing a monetary award of one million US dollars. "I warmly congratulate Professor Genzel for this well-deserved award which highlights some of the best science produced with ESO's telescopes," says Tim de Zeeuw, ESO's Director General. "Professor Genzel and his team have made a dedicated, long-term effort, using our telescopes and co-developing instruments, to study the Centre of our Galaxy, and as such, he has allowed us to enter an era of observational black hole physics." In 1969, Donald Lynden-Bell and Martin Rees suggested that the Milky Way might contain a supermassive black hole at its centre. But evidence for such an object was lacking at the time because the centre of the Milky Way is obscured by interstellar dust, and was detected only as a relatively faint radio source. Reinhard Genzel and his collaborators obtained compelling evidence for this black hole by developing state-of-the-art astronomical instruments to be used on ESO's telescopes and carrying out a persistent programme of observing the Galactic Centre and its surrounding stars for many years, which ultimately led to the discovery of a black hole with a mass of about three million times that of the Sun. Genzel's group has in particular followed since 1992, the motion of several stars, around the Galactic Centre. These observations were first done with the MPE-built near-infrared speckle imaging camera SHARP on ESO's New Technology Telescope at La

  6. Hourly photosynthetically active radiation estimation in Midwestern United States from artificial neural networks and conventional regressions models.

    Science.gov (United States)

    Yu, Xiaolei; Guo, Xulin

    2016-08-01

    The relationship between hourly photosynthetically active radiation (PAR) and the global solar radiation (R s ) was analyzed from data gathered over 3 years at Bondville, IL, and Sioux Falls, SD, Midwestern USA. These data were used to determine temporal variability of the PAR fraction and its dependence on different sky conditions, which were defined by the clearness index. Meanwhile, models based on artificial neural networks (ANNs) were established for predicting hourly PAR. The performance of the proposed models was compared with four existing conventional regression models in terms of the normalized root mean square error (NRMSE), the coefficient of determination (r (2)), the mean percentage error (MPE), and the relative standard error (RSE). From the overall analysis, it shows that the ANN model can predict PAR accurately, especially for overcast sky and clear sky conditions. Meanwhile, the parameters related to water vapor do not improve the prediction result significantly.

  7. CHIS – Letter from French health insurance authorities "Assurance Maladie" and “frontalier” status

    CERN Multimedia

    2014-01-01

    Certain members of the personnel residing in France have recently received a letter, addressed to themselves and/or their spouse, from the French health insurance authorities (Assurance Maladie) on the subject of changes in the health insurance coverage of “frontalier” workers.   It should be recalled that employed members of personnel (MPE) are not affected by the changes made by the French authorities to frontalier  workers' "right to choose" (droit d'option) in matters of health insurance (see the CHIS website for more details), which took effect as of 1 June 2014, as they are not considered to be frontalier workers. Associated members of the personnel (MPA) are not affected either, unless they live in France and are employed by a Swiss institute. For the small number of MPAs in the latter category who might be affected, as well as for family members who do have frontalier status, CERN is still in discussion with the authorities o...

  8. Mathematical paradigms of climate science

    CERN Document Server

    Cannarsa, Piermarco; Jones, Christopher; Portaluri, Alessandro

    2016-01-01

    This book, featuring a truly interdisciplinary approach, provides an overview of cutting-edge mathematical theories and techniques that promise to play a central role in climate science. It brings together some of the most interesting overview lectures given by the invited speakers at an important workshop held in Rome in 2013 as a part of MPE2013 (“Mathematics of Planet Earth 2013”). The aim of the workshop was to foster the interaction between climate scientists and mathematicians active in various fields linked to climate sciences, such as dynamical systems, partial differential equations, control theory, stochastic systems, and numerical analysis. Mathematics and statistics already play a central role in this area. Likewise, computer science must have a say in the efforts to simulate the Earth’s environment on the unprecedented scale of petabytes. In the context of such complexity, new mathematical tools are needed to organize and simplify the approach. The growing importance of data assimilation te...

  9. Response surface analysis of synergistic interactions of morphine and gabapentin in a rat model of postoperative pain

    DEFF Research Database (Denmark)

    Papathanasiou, Theodoros; Juul, Rasmus Vestergaard; Heegaard, Anne-Marie

    evaluated in the plantar incision model in the rat using an electronic von Frey device (1). The percentage of maximum possible effect (%MPE) and the area under the response curve (AUC) were used for the evaluation of the antihyperalgesic effects of the drugs. Identification of synergistic interactions...... on the AIC criterion. Result The combination of morphine and gabapentin resulted in synergistic antihyperalgesic effects. The synergistic interactions were found to be dose dependent and the increase in observed response compared to the theoretical additive response ranged between 26 and 58...... % for the synergistic doses. Conclusions The finding of dose-dependent synergistic interactions might indicate that there is a high potential for gabapentin and morphine to be used in combination in the clinic, in order to optimize postoperative pain management and minimize side effects of morphine. 1. Brennan TJ...

  10. Ionic transport in P(VdF–HFP)–PEO based novel microporous polymer electrolytes

    Indian Academy of Sciences (India)

    M Deka; A Kumar

    2009-12-01

    A novel microporous polymer electrolyte (MPE) comprising blends of poly(vinylidene fluoride-cohexafluoropropylene) [P(VdF–HFP)] and polyethylene oxide (PEO) was prepared by phase inversion technique. It was observed that addition of PEO improved the pore configuration, such as pore size, pore connectivity and porosity of P(VdF–HFP) based membranes. The room temperature ionic conductivity was significantly enhanced. The highest porosity of about 65% and ionic conductivity of about 7 × 10-4 S cm-1 was obtained when the weight ratio of PEO was 40%. The liquid electrolyte uptake was found to increase with increase in porosity and pore size. However, at higher weight ratio of PEO (> 40%) porosity, pore size and ionic conductivity was decreased. This descending trend with further increase of PEO weight ratio was attributed to conglomeration effect of PEO at the pores.

  11. Chaos Based Secure IP Communications over Satellite DVB

    Science.gov (United States)

    Caragata, Daniel; El Assad, Safwan; Tutanescu, Ion; Sofron, Emil

    2010-06-01

    The Digital Video Broadcasting—Satellite (DVB-S) standard was originally conceived for TV and radio broadcasting. Later, it became possible to send IP packets using encapsulation methods such as Multi Protocol Encapsulation, MPE, or Unidirectional Lightweight Encapsulation, ULE. This paper proposes a chaos based security system for IP communications over DVB-S with ULE encapsulation. The proposed security system satisfies all the security requirements while respecting the characteristics of satellite links, such as the importance of efficient bandwidth utilization and high latency time. It uses chaotic functions to generate the keys and to encrypt the data. The key management is realized using a multi-layer architecture. A theoretical analysis of the system and a simulation of FTP and HTTP traffic are presented and discussed to show the cost of the security enhancement and to provide the necessary tools for security parameters setup.

  12. Kan nye VHS udbrud i regnbueørred forebygges ved vaccination eller avl?

    DEFF Research Database (Denmark)

    Lorenzen, Niels

    Tørlægning og desinfektion har traditionelt været brugt til at bekæmpe virussygdommen Egtvedsyge (VHS) i danske ørred-dambrug og lige nu regnes VHS for udryddet. Det har dog vist sig, at der hos vilde fiskebestande i havet findes VHS virus, som under visse omstændigheder må forventes at kunne...... virussygdom hos opdrættede regnbueørreder. Sygdommen er anmeldepligtig. Der har tidligere være lavet forsøg på fremavle fisk, der er resistente overfor VHS eller andre infektioner. Dette kan godt lade sig gøre, men er mere tidskrævende end vaccineudvikling. Dertil kommer at man kan risikere at øget resistens...... mod fx VHS medfører øget modtagelighed overfor andre infektioner. En bedre strategi vil derfor være at identificere genetiske markører for sygdomsresistens....

  13. Vietnam in the 1980s: price reforms and stabilisation

    Directory of Open Access Journals (Sweden)

    S. LEUNG

    2013-10-01

    Full Text Available Before the 1980s, Vietnam was modelled as a centrally-planned economy (CPE along the same lines as the Soviet economy. During the 1980-88 period a kind of 'modified' planned economy (MPE developed in which some partial reforms were effected within the CPE framework. These reforms and Vietnam's latest plans and reforms are surveyed. Economic reform measures in 1985 focused on the insignificant monetary overhang problem, which involved 'forced' money holdings by households owing to shortages in consumer goods. At the same time, it failed to address the problem of 'flow' of net domestic credit extended to the government and state-owned enterprises. Confiscatory monetary reform aggravated the situation as it reduced the demand for real balances. Budgetary and credit limits and shifts in asset portfolio choices by the Vietnamese, on the other hand, were responsible for the success of the 1989 reforms.

  14. Genetic transformation of marine cyanobacterium Synechococcus sp.CC9311 (Cyanophyceae) by electroporation

    Institute of Scientific and Technical Information of China (English)

    CHEN Huaxin; LIN Hanzhi; JIANG Peng; LI Fuchao; QIN Song

    2013-01-01

    Synechococcus sp.CC9311 is a marine cyanobacterium characterized by type V chromatic acclimation (CA).A genetic transformation system was developed as a first step to elucidate the molecular mechanism of CA.The results show that Synechococcus sp.CC9311 cells were sensitive to four commonly used antibiotics:ampicillin,kanamycin,spectinomycin,and chloramphenicol.An integrative plasmid to disrupt the putative phycoerythrin lyase gene mpeV,using a kanamycin resistance gene as selectable marker,was constructed by recombinant polymerase chain reaction.The plasmid was then transformed into Synechococcus sp.CC9311 via electroporation.High transformation efficiency was achieved at a field strength of 2 kV/cm.DNA analysis showed that rpe V was fully disrupted following challenge of the transformants with a high concentration of kanamycin.In addition,the transformants that displayed poor growth on agar SN medium could be successfully plated on agarose SN medium.

  15. Synergism of the analgesic activities of tramadol with α2 adrenoreceptor agonist xylazine in mice

    Directory of Open Access Journals (Sweden)

    G. A. Taqa

    2012-01-01

    Full Text Available The present study was undertaken to evaluate the antinociceptive interaction between tramadol and xylazine. The antinociceptive effect of intraperitoneal (I.P administration of the drug alone or in combination was evaluated using the mouse hot-plate test. Administration of tramadol in fixed dose (20mgkg I.P with different doses of xylazine (0, 2, 4, 8 mgkg I.P significantly referred synergism of the antinociceptive effect of tramadol depending on the dose of xylazine. There was an increased the antinociceptive maximum possible effect (%MPE from (27.08% to (85.4%. The effective dose that produce 50% antinociceptive (ED50 were evaluated for each drug alone or in combination. The present study found that the administration of tramadol and xylazine markedly reduced the median effective dose (ED50 of both drugs for antinociceptive effect in mice. The result of this study demonstrated that there was synergism (super-additive interaction between tramadol and xylazine.

  16. Chinese handwriting recognition an algorithmic perspective

    CERN Document Server

    Su, Tonghua

    2013-01-01

    This book provides an algorithmic perspective on the recent development of Chinese handwriting recognition. Two technically sound strategies, the segmentation-free and integrated segmentation-recognition strategy, are investigated and algorithms that have worked well in practice are primarily focused on. Baseline systems are initially presented for these strategies and are subsequently expanded on and incrementally improved. The sophisticated algorithms covered include: 1) string sample expansion algorithms which synthesize string samples from isolated characters or distort realistic string samples; 2) enhanced feature representation algorithms, e.g. enhanced four-plane features and Delta features; 3) novel learning algorithms, such as Perceptron learning with dynamic margin, MPE training and distributed training; and lastly 4) ensemble algorithms, that is, combining the two strategies using both parallel structure and serial structure. All the while, the book moves from basic to advanced algorithms, helping ...

  17. Enhanced visible light photocatalytic disinfection of gram negative, pathogenic Escherichia coli bacteria with Ag/TiV oxide nanoparticles.

    Science.gov (United States)

    Nair, Ranjith G; Roy, Jetendra Kumar; Samdarshi, S K; Mukherjee, A K

    2011-08-01

    Silver sensitized titanium vanadium mixed Ag/TiV oxide photocatalyst was synthesized using sol-gel technique. The catalyst was characterized using XRD, SEM, EDAX, HRTEM, UV-DRS, XPS, and PL analysis which reveal the formation of a predominantly rutile mixed phase nanoparticles of 25-30 nm crystallite size. The catalyst showed a marked red-shift in the absorption spectrum compared to Degussa P25. It exhibited a remarkable enhancement in the visible light photocatalytic activity in inactivating Escherichia coli, a gram-negative pathogenic bacterium, too. The conclusions are supported by a comparison with an identically synthesized TiV oxide sample. A microbicidal photonic efficiency (MPE) has been defined and a method for its determination has been proposed to facilitate quantification of the performance of the photocatalyst and the disinfection system taking into account the response of the catalyst to the radiation intensity.

  18. Prediction of global solar radiation and comparison with satellite data

    Science.gov (United States)

    Bakirci, Kadir

    2017-01-01

    Data on solar radiation at a related location is very necessary for many solar applications. In the present study, the models are derived to forecast the daily global solar radiation on horizontal plane for the Eastern Anatolia Region (EAR) of Turkey, covering thirteen provinces. The measured data on horizontal plane for the period of 1991-2005 are analyzed. The comparisons of calculated and measured values have been carried out with various statistical test methods. These statistical test methods are the mean bias error (MBE), the main percentage error (MPE), the root mean square error (RMSE) and t-statistic (t-stat). In addition, the comparisons of the solar radiation values of the National Aeronautics and Space Administration - Surface meteorology and Solar Energy (NASA-SSE) and calculated from the Model 3 with the higher determination coefficient is performed.

  19. The intracerebroventricular (ICV) administration of W-7, a calmodulin inhibitor, attenuates the development of morphine tolerance in rats.

    Science.gov (United States)

    Sepehri, Gholamreza; Sheibani, Vahid; Azarang, Afrooz; Shamsizadeh, Ali; Afarinesh, Mohammad Reza; Azizollahi, Saeed; Sepehri, Ehsan

    2010-04-01

    The present study was performed to determine the effect of intracerebroventricular (ICV) administration of W-7, a specific calmodulin inhibitor, on the development of tolerance to antinociceptive effect morphine administration. This study was carried out on male wistar rats, weighing 200-250 g. Morphine was administered daily (15 mg/kg for 8 days). The threshold to thermal nociceptive stimuli was measured by tail-flick test. W-7 (0.25, 0.5 and 1 micromol/rat) was injected through ICV. Maximal possible effect percentage (MPE %) was considered as analgesia index. Our result showed that chronic morphine exposure induced tolerance to its antinociceptive effect and administration of W-7 (0.5 and 1 micromol/rat) decreased the development of tolerance to it. In conclusion these data showed that chronic injection of W-7 inhibited the development of morphine tolerance which indicates that calmodulin and its dependent pathways may play a role in the morphine tolerance processes.

  20. Spin Hall magnetoresistance in Co2FeSi/Pt thin films: dependence on Pt thickness and temperature

    Science.gov (United States)

    Huang, Xiufeng; Dai, Zhiwen; Huang, Lin; Lu, Guangduo; Liu, Min; Piao, Hongguang; Kim, Dong-Hyun; Yu, Seong-cho; Pan, Liqing

    2016-11-01

    We have investigated the temperature and the Pt layer thickness dependence of the magnetoresistances (MRs) in Co2FeSi/Pt thin films. Based on the field dependent measurements, it can be seen that the spin-current-induced spin Hall magnetoresistance (SMR) plays the dominant role in the MRs in the Co2FeSi/Pt bilayers in the whole temperature range. Meanwhile, a quite small part of anisotropic magnetoresistance (AMR) existed in the MRs. It proved to be originated from magnetic proximity effect (MPE) by measuring the Pt thickness and temperature dependence of the AMR. Moreover, the Co2FeSi layer thickness has much weaker effect on the SMR and AMR compared to the Pt layer thickness. These results indicate that the Co2FeSi/Pt interface is beneficial to be used in the spin-current-induced physical phenomena.

  1. Topology optimum design of compliant mechanisms using modified ant colony optimization

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Kwang Seon; Han, Seog Young [Hanyang University, Seoul (Korea, Republic of)

    2015-08-15

    A Modified ant colony optimization (MACO) algorithm was suggested for topology optimal design of compliant mechanisms since standard ACO cannot provide an appropriate optimal topology. In order to improve computational efficiency and suitability of standard ACO algorithm in topology optimization for compliant mechanisms, a continuous variable, called the 'Element contribution significance (ECS),'is employed, which serves to replace the positions of ants in the standard ACO algorithm, and assess the importance of each element in the optimization process. MACO algorithm was applied to topology optimizations of both linear and geometrically nonlinear compliant mechanisms using three kinds of objective functions, and optimized topologies were compared each other. From the comparisons, it was concluded that MACO algorithm can effectively be applied to topology optimizations of linear and geometrically nonlinear compliant mechanisms, and the ratio of Mutual potential energy (MPE) to Strain energy (SE) type of objective function is the best for topology optimal design of compliant mechanisms.

  2. Optimering af behandlingseffekten i akvakultur. Minimering af forbrug og udledning af hjælpestoffer

    DEFF Research Database (Denmark)

    Sortkjær, Ole; Henriksen, Niels Henrik; Demuth Heinecke, Rasmus;

    er 1/5 af, hvad der normalt anvendes. Brintoverilte omsættes hurtigt, så det er nødvendigt at supplere med brintoverilte under behandlingen i damme. Forsøg med biofilter viser, at formalin omsættes hurtigere, hvis det i forvejen har været eksponeret med formalin, og det skader ikke den mikrobielle...... behandlingstiden samtidig bliver forlænget, sådan som toksicitetstestene viser. For at bekæmpe fiskedræberen skal der behandles flere gange med nogle dages mellemrum, når dambruget er hårdt inficeret. I recirkulerende anlæg med biofilter er det nødvendigt at supplere med formalin for at holde koncentrationen under...

  3. High-throughput fiber-array transvaginal ultrasound/photoacoustic probe for ovarian cancer imaging

    Science.gov (United States)

    Salehi, Hassan S.; Kumavor, Patrick D.; Alqasemi, Umar; Li, Hai; Wang, Tianheng; Zhu, Quing

    2014-03-01

    A high-throughput ultrasound/photoacoustic probe for delivering high contrast and signal-to-noise ratio images was designed, constructed, and tested. The probe consists of a transvaginal ultrasound array integrated with four 1mm-core optical fibers and a sheath. The sheath encases transducer and is lined with highly reflecting aluminum for high intensity light output and uniformity while at the same time remaining below the maximum permissible exposure (MPE) recommended by the American National Standards Institute (ANSI). The probe design was optimized by simulating the light fluence distribution in Zemax. The performance of the probe was evaluated by experimental measurements of the fluence and real-time imaging of polyethylene-tubing filled with blood. These results suggest that our probe has great potential for in vivo imaging and characterization of ovarian cancer.

  4. Optimering af behandlingseffekten i akvakultur. Minimering af forbrug og udledning af hjælpestoffer

    DEFF Research Database (Denmark)

    Sortkjær, Ole; Henriksen, Niels Henrik; Demuth Heinecke, Rasmus

    er 1/5 af, hvad der normalt anvendes. Brintoverilte omsættes hurtigt, så det er nødvendigt at supplere med brintoverilte under behandlingen i damme. Forsøg med biofilter viser, at formalin omsættes hurtigere, hvis det i forvejen har været eksponeret med formalin, og det skader ikke den mikrobielle...... behandlingstiden samtidig bliver forlænget, sådan som toksicitetstestene viser. For at bekæmpe fiskedræberen skal der behandles flere gange med nogle dages mellemrum, når dambruget er hårdt inficeret. I recirkulerende anlæg med biofilter er det nødvendigt at supplere med formalin for at holde koncentrationen under...

  5. Temperature dependence of carrier capture by defects in gallium arsenide

    Energy Technology Data Exchange (ETDEWEB)

    Wampler, William R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Modine, Normand A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-08-01

    This report examines the temperature dependence of the capture rate of carriers by defects in gallium arsenide and compares two previously published theoretical treatments of this based on multi phonon emission (MPE). The objective is to reduce uncertainty in atomistic simulations of gain degradation in III-V HBTs from neutron irradiation. A major source of uncertainty in those simulations is poor knowledge of carrier capture rates, whose values can differ by several orders of magnitude between various defect types. Most of this variation is due to different dependence on temperature, which is closely related to the relaxation of the defect structure that occurs as a result of the change in charge state of the defect. The uncertainty in capture rate can therefore be greatly reduced by better knowledge of the defect relaxation.

  6. Use of indwelling pleural catheters for the definitive treatment of malignant pleural effusion.

    Science.gov (United States)

    Abrão, Fernando Conrado; Abreu, Igor Renato Louro Bruno de; Cavalcanti, Maria Gabriela; Pompa-Filho, José Franklin Soares

    2017-01-01

    To evaluate the safety and feasibility of the use of indwelling pleural catheters (IPCs) in patients with malignant pleural effusion (MPE). We prospectively collected data from patients with MPE undergoing IPC placement between January of 2014 and July of 2015. All patients submitted to IPC placement had a life expectancy > 30 days, in accordance with the MPE treatment guidelines established by the British Thoracic Society. The data collected included gender, age, body mass index, primary cancer site, duration of IPC drainage, IPC-related complications, length of hospital stay, pleural effusion recurrence, and occurrence of spontaneous pleurodesis. A total of 19 patients underwent IPC placement during the study period. Median overall survival after IPC insertion was 145 days. The median follow-up among the surviving patients was 125 days (range, 53-485 days), and the median time between catheter insertion and removal was 31 days (range, 2-126 days). There were IPC-related complications in 5 patients (26.2%), and spontaneous pleurodesis was achieved in 8 (42.0%). Among those 8 patients, the IPC was removed between days 30 and 126 in 4, and spontaneous pleurodesis occurred within the first 30 days in 4. The use of IPCs seems to be feasible and safe in patients with MPE. Avaliar a segurança e a viabilidade do uso de cateter pleural de longa permanência (CPLP) em pacientes com derrame pleural neoplásico (DPN). Dados referentes a pacientes com DPN que receberam CPLP entre janeiro de 2014 e julho de 2015 foram colhidos prospectivamente. Todos os pacientes que receberam CPLP tinham expectativa de vida > 30 dias, em conformidade com as diretrizes de tratamento de DPN da Sociedade Torácica Britânica. Foram colhidos dados sobre sexo, idade, índice de massa corporal, local do câncer primário, tempo de drenagem com o CPLP, complicações relacionadas com o CPLP, tempo de internação hospitalar, recidiva do derrame pleural e ocorrência de pleurodese espont

  7. Indirect glass slumping for future x-ray missions: overview, status and progress

    Science.gov (United States)

    Winter, Anita; Breunig, Elias; Friedrich, Peter; Proserpio, Laura; Döhring, Thorsten

    2015-09-01

    Future X-ray telescopes aim for large effective area within the given mass limits of the launcher. A promising method is the hot shaping of thin glass sheets via a thermal slumping process. This paper presents the status and progress of the indirect glass slumping technology developed at the Max-Planck-Institut for extraterrestrial Physics (MPE). Recent developments in our research include the use of the mould material Cesic under vacuum, as well as the fabrication of a high-precision slumping mould, which meets the requirements of large, high angular resolution missions like ATHENA. We describe the way forward to optimise the slumping process on these materials, the force-free integration concept and its progress, as well as the first test on reflective coating application.

  8. VizieR Online Data Catalog: The BMW-HRI source catalogue (Panzera+, 2003)

    Science.gov (United States)

    Panzera, M. R.; Campana, S.; Covino, S.; Lazzati, D.; Mignani, R. P.; Moretti, A.; Tagliaferri, G.

    2002-11-01

    The BMW-HRI catalogue is generated from US and German ROSAT HRI observations for which data have been released to the US ROSAT archive at GSFC and to the German ROSAT archive at MPE up to December 2001. A total number of 4,303 observations with exposure times longer than 100 s were analyzed automatically using a wavelet detection algorithm. The catalogue consists of 29,089 sources (detection probability greater or equal 4.2 sigma). For each source name, position, count rate, flux and extension along with the relative errors are given.The catalogue also reports results of cross-correlations with existing catalogues at different wavelengths (FIRST, GSC2, 2MASS, and IRAS). (1 data file).

  9. FEMALE STUDENTS IN ENGINEERING Geology, Mining, and Petroleum Engineering Comparison

    Directory of Open Access Journals (Sweden)

    Jasminka Lažnjak

    1997-12-01

    Full Text Available Engineering professions genceraly went last decades through process of feminization, but not equaly. The article is focused on one of the most male dominant profession - mining, geology and petroleum engineering (MGPE. This study will examine the percentage of female students and graduates from mining college and their achievement on udergraduate level in eleven years period. Data show a significant differences in female students enrolment among geology (35% women and mining and petroleum engineering (14% women. The theoretical background in explanation why women are marginal group in MPE is based on two different approaches: technological determinism and social shaping of technology. The role of technology in altering of women position in society is significant. The social construction of technology thesis stresses social factors and interests of main actors which in this case include the reproduction of tradilional value system and occupational segregation.

  10. Utilization of mustard waste isolates for improved production of astaxanthin by Xanthophyllomyces dendrorhous.

    Science.gov (United States)

    Tinoi, J; Rakariyatham, N; Deming, R L

    2006-04-01

    Astaxanthin production in the wild strain Xanthophyllomyces dendrorhous TISTR 5730 was investigated using different mustard waste media, including mustard waste residue extract (MRE), mustard waste residue hydrolysate (MRH), mustard waste precipitated extract (MPE), and mustard waste precipitated hydrolysate (MPH). The growth of X. dendrorhous and the production of astaxanthin were dependent on the type and initial concentrations of mustard waste media. The MPH medium was the best substrate resulting in yields of biomass and astaxanthin of 19.6 g/L and 25.8 mg/L, respectively, under optimal conditions. MPH medium improved astaxanthin production 11-fold compared to the commonly used commercial yeast malt medium, and 1.3-2.1-fold compared to other mustard waste media.

  11. Las dificultades de la integración latinoamericana a partir del modelo primario exportador

    Directory of Open Access Journals (Sweden)

    Ricardo E. Buitrago R.

    2006-01-01

    Full Text Available Latinoamérica se ha desarrollado dentro de los patrones del denominado Modelo Primario Exportador (MPE y su inserción en el mercado internacional ha difi cultado la propia cohesión e integración regional. La dependencia histórica profundizada a partir de los modelos neoliberales post Consenso de Washington hace evidente un modelo de marginación periférica estructural. Este regionalismo abierto propone un desarrollo regional con estrategias basadas en iniciativas de recursos endógenos y mercados externos, en un marco político de desconcentración y descentralización. La fórmula única de triunfo es insertarse, con las potencialidades internas, en el mercado internacional de forma competitiva, dejando de lado los modelos políticos de dependencia tecnológica, política y económica.

  12. Avaliação de micro e pequenas empresas utilizando a metodologia multicritério e o método do fluxo de caixa descontado DOI:10.5007/2175-8077.2010v12n26p48

    Directory of Open Access Journals (Sweden)

    Marcus Vinicius Andrade de Lima

    2010-01-01

    Full Text Available Normal 0 21 false false false MicrosoftInternetExplorer4 Neste artigo é apresentada uma contribuição ao método do fluxo de caixa descontado utilizando a metodologia multicritério de apoio à decisão. Esta metodologia incorpora variáveis de natureza qualitativa e subjetiva ao método tradicional do fluxo de caixa descontado utilizado na avaliação de empresas. Para ilustrar o método proposto foi realizado um estudo descritivo de natureza exploratória aplicado a um multicaso. A intervenção foi em Micro e Pequenas Empresas (MPE do ramo químico, farmacêutico e de turismo. Como resultado, o avaliador ajustou o preço do negócio levando em conta a resultante da mixagem entre as duas metodologias.

  13. Kampen om sandheden

    DEFF Research Database (Denmark)

    Glerup, Cecilie; Degnbol, Marie Chimwemwe

    2014-01-01

    Hvad betyder politiske kulturer for brugen af videnskab? Cecilie Glerup og Marie Degnbol undersøger, hvordan en dansk klima-NGO inddrager videnskab i sine forsøg på at skabe hårdtslående kritik på klimaområdet. Ifølge de to forfattere forsøger NGO’en at bekæmpe „falsk konfliktualitet“ – at folk e...... uenige om klimaforandringernes omfang, fordi de ikke kender den sande karakter af katastrofen. NGO’en ser med andre ord enighed og fællesskab som en betingelse for forandring, noget forfatterne mener, er levn fra Grundtvig og Højskolebevægelsen....

  14. Artificial neural network and response surface methodology modeling in mass transfer parameters predictions during osmotic dehydration of Carica papaya L.

    Directory of Open Access Journals (Sweden)

    J. Prakash Maran

    2013-09-01

    Full Text Available In this study, a comparative approach was made between artificial neural network (ANN and response surface methodology (RSM to predict the mass transfer parameters of osmotic dehydration of papaya. The effects of process variables such as temperature, osmotic solution concentration and agitation speed on water loss, weight reduction, and solid gain during osmotic dehydration were investigated using a three-level three-factor Box-Behnken experimental design. Same design was utilized to train a feed-forward multilayered perceptron (MLP ANN with back-propagation algorithm. The predictive capabilities of the two methodologies were compared in terms of root mean square error (RMSE, mean absolute error (MAE, standard error of prediction (SEP, model predictive error (MPE, chi square statistic (χ2, and coefficient of determination (R2 based on the validation data set. The results showed that properly trained ANN model is found to be more accurate in prediction as compared to RSM model.

  15. Hourly photosynthetically active radiation estimation in Midwestern United States from artificial neural networks and conventional regressions models

    Science.gov (United States)

    Yu, Xiaolei; Guo, Xulin

    2016-08-01

    The relationship between hourly photosynthetically active radiation (PAR) and the global solar radiation ( R s ) was analyzed from data gathered over 3 years at Bondville, IL, and Sioux Falls, SD, Midwestern USA. These data were used to determine temporal variability of the PAR fraction and its dependence on different sky conditions, which were defined by the clearness index. Meanwhile, models based on artificial neural networks (ANNs) were established for predicting hourly PAR. The performance of the proposed models was compared with four existing conventional regression models in terms of the normalized root mean square error (NRMSE), the coefficient of determination ( r 2), the mean percentage error (MPE), and the relative standard error (RSE). From the overall analysis, it shows that the ANN model can predict PAR accurately, especially for overcast sky and clear sky conditions. Meanwhile, the parameters related to water vapor do not improve the prediction result significantly.

  16. Radial basis network analysis of color parameters to estimate lycopene content on tomato fruits.

    Science.gov (United States)

    Fernández-Ruiz, Virginia; Torrecilla, José S; Cámara, Montaña; Mata, Ma Cortes Sánchez; Shoemaker, Charles

    2010-11-15

    With the purpose of estimating the lycopene concentration in tomato food samples, in an non-destructive way, several types of linear models of color parameters have been tested using individual values of L*, a* and b* values, (a*/b*), (a*(2)/b*(2)) and chroma parameters from tomato juice and fresh tomato fruits obtained with two different apparatus (Minolta CR-200b triestimulus colorimeter and HunterLab LabScan XE). Lycopene concentrations of fresh tomato and tomato juice (used as an input) were analyzed by UV-Vis spectroscopy. For all linear methods applied, the best one to estimate the lycopene concentration in tomato was the L*, a* and b* values of tomato juice measured with Hunter colorimeters (adjusted correlation coefficient, R(a)(2)>0.86 and mean prediction error, MPEcolor parameters (L*, a* and b*) designated as "Lab case", and secondly individually by the (a*/b*), (a*(2)/b*(2)) and chroma parameters. The lycopene concentration estimations were carried out with the lowest MPE and highest R(a)(2) values possible. In order to test the reliability of the non-linear models, external validation process was also performed. From the testing of the all non-linear models applied, the RBEF Lab case model was the best to estimate lycopene content from color parameters (L*, a* and b*) using Minolta or Hunter equipments (MPE lower than 0.009 and R(a)(2) higher than 0.997). This was a simple non-destructive method for predicting lycopene concentration in tomato fruits and tomato juice, which was reproducible and accurate enough to substitute chemical extraction determinations, and may be a useful tool for tomato industry.

  17. Analgesic effect of the aqueous and ethanolic extracts of clove

    Directory of Open Access Journals (Sweden)

    Mina Kamkar Asl

    2013-04-01

    Full Text Available Objective: The beneficial effects of clove on toothache have been well documented. We have also previously shown the analgesic effects of clove essential oil. The present work was done to investigate the analgesic effects of the aqueous extract of clove using hot plate test. The possible role of opioid receptors in the analgesic effects of clove was also investigated using naloxone. Materials and Methods: Ninety male mice were divided into nine groups: (1 Saline, (2-4 Aaqueous (Aq 50, Aq 100, and Aq 200 groups which were treated with 50, 100, and 200 mg/kg of aqueous extract of clove, respectively, (5-7 Ethanolic (Eth 50, Eth 100, and Eth 200 groups which were treated with 50, 100, and 200 mg/kg of ethanolic extract of clove, respectively, and (8-9 Aq 100- Naloxone and Aq 200- Naloxone which were pretreated with 4 mg/kg of naloxone before injection of 100 or 200 mg/kg of the aqueous extract. The hot plate test was performed as a base record 10 min before injection of drugs and consequently repeated every 10 minutes after the injection. Results: The maximal percent effect (MPE in the animal groups treated with 50, 100, and 200 mg/kg of aqueous extract was significantly higher than the control group. Pretreatment with naloxone reduced the analgesic effects of both 100 and 200 mg/kg of the aqueous extract. Administration of all three doses of the ethanloic extract also non-significantly increased the MPE. Conclusion: The results of the present study showed that aqueous extract of clove has analgesic effect in mice demonstrated by hot plate test which is reversible by naloxone. The role of opioid system in the analgesic effect of clove might be suggested. However, more investigations are needed to elucidate the exact mechanism(s.

  18. Action spectrum for photochemical retinal pigment epithelium (RPE) disruption in an in vivo monkey model

    Science.gov (United States)

    Zhang, Jie; Sabarinathan, Ranjani; Bubel, Tracy; Williams, David R.; Hunter, Jennifer J.

    2016-03-01

    Observations of RPE disruption and autofluorescence (AF) photobleaching at light levels below the ANSI photochemical maximum permissible exposure (MPE) (Morgan et al., 2008) indicates a demand to modify future light safety standards to protect the retina from harm. To establish safe light exposures, we measured the visible light action spectrum for RPE disruption in an in vivo monkey model with fluorescence adaptive optics retinal imaging. Using this high resolution imaging modality can provide insight into the consequences of light on a cellular level and allow for longitudinal monitoring of retinal changes. The threshold retinal radiant exposures (RRE) for RPE disruption were determined for 4 wavelengths (460, 488, 544, and 594 nm). The anaesthetized macaque retina was exposed to a uniform 0.5° × 0.5° field of view (FOV). Imaging within a 2° × 2° FOV was performed before, immediately after and at 2 week intervals for 10 weeks. At each wavelength, multiple RREs were tested with 4 repetitions each to determine the threshold for RPE disruption. For qualitative analysis, RPE disruption is defined as any detectable change from the pre exposure condition in the cell mosaic in the exposed region relative to the corresponding mosaic in the immediately surrounding area. We have tested several metrics to evaluate the RPE images obtained before and after exposure. The measured action spectrum for photochemical RPE disruption has a shallower slope than the current ANSI photochemical MPE for the same conditions and suggests that longer wavelength light is more hazardous than other measurements would suggest.

  19. Effects of injection systems and plastic mulches on distribution and emissions of cis- and trans-1,3-dichloropropene and chloropicrin.

    Science.gov (United States)

    Ou, Li-Tse; Thomas, John E; Allen, L Hartwell; Vu, Joseph C; Dickson, Donald W

    2007-08-01

    The concentration and distribution of a soil fumigant in the subsurface of field plots are two key factors in the determination of the fumigant efficacy. Subsurface concentrations of the biologically active compounds cis- and trans-1,3-dichloropropene (1,3-D) and chloropicrin (CP) were determined in soil at two adjacent injection traces and midpoint between the two traces in plastic-covered field beds after injection of the fumigant Telone C35 by conventional chisels or by a coulter rig (Avenger coulters). Two of the four beds were covered with metallic polyethylene film (MPE) and the remaining two were covered with virtually impermeable film (VIF). Three hours after chisel injection, concentrations of the three compounds at the two adjacent injection traces in the two beds were highly variable. Large concentrations of the compounds were detected at the side traces, whereas the compounds were not detected at the middle traces (bed centers) in the two chisel-injected beds covered with MPE or VIF. Initial concentrations of the three compounds at the two adjacent injection traces in the two Avenger-coulter-injected beds were more uniform than in the chisel-injected beds but still variable. Also, the three compounds had diffused horizontally to midpoint between the two injection traces in all four beds, generally in smaller concentrations. Concentrations of the three compounds in the shallow subsurface soil layer (0.5-30 cm) in the beds became progressively more uniform and then declined slowly. Volatilization losses from the two Avenger-coulter-injected beds and the chisel-injected bed covered with VIF were low. Combination of Avenger coulter injection and VIF provided better retention of the compounds in this soil layer and, thus, likely would provide better fumigant efficacy and crop yield.

  20. Using the Mercy Method for Weight Estimation in Indian Children

    Directory of Open Access Journals (Sweden)

    Gitanjali Batmanabane MD, PhD

    2015-01-01

    Full Text Available This study was designed to compare the performance of a new weight estimation strategy (Mercy Method with 12 existing weight estimation methods (APLS, Best Guess, Broselow, Leffler, Luscombe-Owens, Nelson, Shann, Theron, Traub-Johnson, Traub-Kichen in children from India. Otherwise healthy children, 2 months to 16 years, were enrolled and weight, height, humeral length (HL, and mid-upper arm circumference (MUAC were obtained by trained raters. Weight estimation was performed as described for each method. Predicted weights were regressed against actual weights and the slope, intercept, and Pearson correlation coefficient estimated. Agreement between estimated weight and actual weight was determined using Bland–Altman plots with log-transformation. Predictive performance of each method was assessed using mean error (ME, mean percentage error (MPE, and root mean square error (RMSE. Three hundred seventy-five children (7.5 ± 4.3 years, 22.1 ± 12.3 kg, 116.2 ± 26.3 cm participated in this study. The Mercy Method (MM offered the best correlation between actual and estimated weight when compared with the other methods (r2 = .967 vs .517-.844. The MM also demonstrated the lowest ME, MPE, and RMSE. Finally, the MM estimated weight within 20% of actual for nearly all children (96% as opposed to the other methods for which these values ranged from 14% to 63%. The MM performed extremely well in Indian children with performance characteristics comparable to those observed for US children in whom the method was developed. It appears that the MM can be used in Indian children without modification, extending the utility of this weight estimation strategy beyond Western populations.