WorldWideScience

Sample records for extraterrestrische physik mpe

  1. Gerthsen Physik

    CERN Document Server

    2015-01-01

    Auf mehr als 1000 Seiten findet man von der Kinematik des Massenpunktes über die Quantenchromodynamik, die Fullerene, die Halbleiterlaser, die Hochtemperatur-Supraleiter bis hin zum Chaos im Kochtopf praktisch alles, was Physik heute ausmacht. ... In diesem sehr weit gespannten Bogen nimmt der Gerthsen den Platz eines echten, ja eigentlich des einzigen Kompendiums der Physik ein. Kein Physiker kommt heute noch ohne dieses Werk aus. (Physikalische Blätter) Für die Studierenden der Physik im Haupt- und Nebenfach ist der Gerthsen ein unverzichtbarer und kompetenter Begleiter durch das gesamte Studium, das jetzt in der Neuauflage noch preisgünstiger zu erwerben ist. Nahezu alle Studierenden beginnen mit dem Klassiker Gerthsen. Sämtliche Gebiete der Physik werden ausführlich und gut verständlich dargestellt. Das Buch stellt alle klassischen Themen vor - Mechanik, Wärmelehre, Elektrodynamik, Optik. Darauf aufbauende Themen der klassischen Physik wie die Nichtlineare Dynamik und die Relativitätstheorie sin...

  2. Faszination Physik

    CERN Document Server

    2004-01-01

    30 von renommierten Experten verfasste Essayartikel liefern einen integrierenden Überblick über einzelne Fachgebiete und Aspekte der Physik oder widmen sich aktuellen Forschungsgebieten. Das Themengebiet reicht dabei von der Teilchenphysik über Fullerene und Biophysik bis hin zur Bose-Einstein-Kondensation und Quanteninformatik. Die Faszination Physik richtet sich an Studierende der Physik und an alle, die sich für Experimente und Erkenntnisse in der Physik begeistern können und will explizit zum Schmökern und ausführlichen Nachlesen einladen. Katja Bammel, fertigte ihre Diplomarbeit am Max-Planck-Institut für Strömungsphysik in Göttingen an und promovierte an der FU Berlin. Seit 1999 lebt sie mit ihrer Familie in Cagliari (Italien) und arbeitet als freie Wissenschaftsjournalistin. Erste Erfahrungen in diesem Bereich sammelte sie schon zuvor als Autorin für Lexikon der Physik. Seitdem wirkte sie an weiteren Nachschlagwerken wie Der Brockhaus Naturwissenschaft und Technik und dem Lexikon bedeutender...

  3. Donnerwetter - Physik!

    CERN Document Server

    Peter Häussler

    2001-01-01

    Auf einer Geburtstagsparty werden Jugendlichen sieben Zauberkunststücke vorgeführt. Sieben erstaunliche Phänomene, die Anne und ihre Freunde zunächst vor Rätsel stellen. Doch so nach und nach kommen sie den Tricks auf die Spur. Mit der Unterstützung eines Nachbarn, einem pensionierten Physiker, entwickeln sie dazu physikalische Ideen: Anhand des Gewichts von Schokolade wird die Einheit für die Kraft diskutiert, "Schau mir in die Augen" leitet ein Gespräch über die Bildentstehung ein. Das Beobachten von Zugvögeln ist Aufhänger für den Magnetismus, und ein heftiges Gewitter gibt Anlass zum Nachdenken über die Elektrizität. Auch die von Physikern entwickelten Vorstellungen zu Quarks, Weißen Zwergen und Schwarzen Löchern kommen zur Sprache. Peter Häußler ist Professor für die Didaktik der Physik an der Universität Kiel und versteht es, lebendig und spannend zu schreiben. Über die Grundlagen der Physik hinaus erfährt der Leser auch etwas über ihre Erkenntnismethoden und den Unterschied zwisc...

  4. Calibration of hard x-ray (15 - 50 keV) optics at the MPE test facility PANTER

    Science.gov (United States)

    Bräuninger, Heinrich; Burkert, Wolfgang; Hartner, Gisela D.; Citterio, Oberto; Ghigo, Mauro; Mazzoleni, Francesco; Pareschi, Giovanni; Spiga, Daniele

    2004-02-01

    The Max-Planck-Institut für extraterrestrische Physik (MPE) in Garching, Germany, operates the large X-ray beam line facility PANTER for testing astronomical systems. At PANTER a number of telescopes like EXOSAT, ROSAT, SAX, JET-X, ABRIXAS, XMM and SWIFT operating in the soft energy range (0.02 - 15 keV) have been successfully calibrated. In the present paper we report on an important upgrade recently implemented that enables the calibration of hard X-ray optics (from 15 up to 50 keV). Currently hard X-ray optics based on single and multilayer coating are being developed for several future X-ray missions. The hard X-ray calibrations at PANTER are carried out by a high energy source based on an electron gun and several anodes, able to cover the energy range from 4.5 up to 50 keV. It provides fluxes up to 104 counts/sec/cm2 at the instrument chamber with a stability better than 1%. As detector a pn-CCD camera operating between 0.2 and 50 keV and a collecting area of 36 cm2 is used. Taking into account the high energy resolution of the CCD (145 eV at 6 keV), a very easy way to operate the facility in hard X-ray is in energy-dispersive mode (i.e. with a broad-band beam). A double crystal monochromator is also available providing energies up to 20 keV. In this paper we present the first results obtained by using PANTER for hard X-ray characterizations, performed on prototype multilayer optics developed by the Osservatorio Astronomico di Brera (OAB), Milano, Italy, and the Harvard-Smithsonian Center for Astrophysics (CfA), Cambridge, MA, USA.

  5. Theoretische Konzepte der Physik

    Science.gov (United States)

    Longair, Malcolm S.; Simon, B.; Simon, H.

    "Dies ist kein Lehrbuch der theoretischen Physik, auch kein Kompendium der Physikgeschichte ... , vielmehr eine recht anspruchsvolle Sammlung historischer Miniaturen zur Vergangenheit der theoretischen Physik - ihrer "Sternstunden", wenn man so will. Frei vom Zwang, etwas Erschöpfendes vorlegen zu müssen, gelingt dem Autor etwas Seltenes: einen "lebendigen" Zugang zum Ideengebäude der modernen Physik freizulegen, ... zu zeigen, wie Physik in praxi entsteht... Als Vehikel seiner Absichten dienen dem Autor geschichtliche Fallstudien, insgesamt sieben an der Zahl. Aus ihnen extrahiert er das seiner Meinung nach Lehrhafte, dabei bestrebt, mathematische Anachronismen womöglich zu vermeiden... Als Student hätte ich mir diese gescheiten Essays zum Werden unserer heutigen physikalischen Weltsicht gewünscht. Sie sind originell, didaktisch klug und genieren sich auch nicht, von der Faszination zu sprechen, die ... von der Physik ausgeht. Unnötig darauf hinzuweisen, das sie ein gründliches "konventionelles" Studium weder ersetzen wollen noch können, sie vermögen aber, dazu zu ermuntern." #Astronomische Nachrichten (zur englischen Ausgabe)#1

  6. Ideengeschichte der Physik

    CERN Document Server

    Kuhn, Wildfried

    2016-01-01

    Die Ideengeschichte der Physik geht neue Wege, indem sie den umfangreichen historischen Stoff nicht additiv darstellt, sondern wissenschaftstheoretisch reflektiert und nach thematischen Leitlinien (Materievorstellungen, Raum und Zeit, Erhaltungskonzepte, Extremalprinzipien, Theorie und Experiment) strukturiert. Damit vermittelt diese Darstellung im historischen Kontext ein tieferes Verständnis des physikalischen Denkens von der Antike bis heute und lotet zugleich die Dimension der Genesis physikalischer Begriffe aus, die in modernen Lehrbüchern zumeist nicht dargelegt wird. Das Credo Kuhns: Wer über die handwerkliche Handhabung von Physik hinausgehen will, muss sich zwingend mit der Frage befassen, was physikalisches Denken ausmacht und wie es entstanden ist. Die vorliegende zweite Auflage wurde ergänzt durch ein Vorwort von Prof. Dr. Oliver Schwarz, der im Institut Wilfried Kuhns forschen konnte und dabei dessen Denk- und Arbeitsweisen kennengelernt hat.

  7. Moderne mathematische Methoden der Physik

    CERN Document Server

    Goldhorn, Karl-Heinz; Kraus, Margarita

    2010-01-01

    Der große Vorzug dieses Lehrbuchs liegt in seiner kompromisslosen Konzentration auf begriffliche Klarheit bei bewusstem Verzicht auf für Physiker irrelevante Details. Es richtet sich u.a. an Studierende von Master-, Aufbau-, Graduierten- und Promotionsstudiengängen im Bereich der theoretischen und mathematischen Physik. Die Auswahl des Stoffes deckt ein breites Spektrum mathematischer Konzepte und Methoden ab, die für die heutige Physik relevant sind. Dieser zweite Band konzentriert sich dabei auf mathematische Grundlagen der Quantenmechanik: Unbeschränkte Operatoren im Hilbertraum, Spektraltheorie sowie Symmetriegruppen und ihre Darstellungen mit besonderem Augenmerk auf Rotations- und Lorentzgruppe.

  8. Physik gestern und heute Spurensuche

    Science.gov (United States)

    Engels, Wolfgang; Heering, Peter

    2005-01-01

    Im Jahre 1927 erhielt Charles Thomson Rees Wilson für die von ihm entwickelte Methode zur Visualisierung der Spuren ionisierender Strahlung den Nobelpreis für Physik. Die nach ihm benannte Nebelkammer wurde in der ersten Hälfte des 20. Jahrhunderts zu einem Standardinstrument für Untersuchungen subatomarer Prozesse.

  9. MPE inference in conditional linear gaussian networks

    DEFF Research Database (Denmark)

    Salmerón, Antonio; Rumí, Rafael; Langseth, Helge

    2015-01-01

    Given evidence on a set of variables in a Bayesian network, the most probable explanation (MPE) is the problem of finding a configuration of the remaining variables with maximum posterior probability. This problem has previously been addressed for discrete Bayesian networks and can be solved using...

  10. Physik im 21. Jahrhundert Essays zum Stand der Physik

    CERN Document Server

    Röss, Dieter

    2011-01-01

    Physik ist eine höchst lebendige Wissenschaft! Einmal gewonnene Grundlagen-Erkenntnisse lassen sich auf unübersehbar viele Anwendungsbereiche anwenden. Experimentell gesichertes Detailwissen wächst heute in wenigen Dekaden lawinenartig in eine Größenordnung, die selbst für den Fachmann im Ganzen nicht mehr überschaubar ist. Dieses Werk wählt einen neuen Zugang: Beschränkung auf wenige, exemplarische Teilgebiete der modernen Physik bei Darstellung ihrer Zusammenhänge in aller Tiefe. Verfasser der Beiträge sind herausragende Wissenschaftler mit großer Lebenserfahrung, die dem Leser in ihrem Fachgebiet Zusammenhänge erschließen und Ausblicke in zukünftige Möglichkeiten eröffnen. Mit ihrer in langjähriger Lehrtätigkeit gesammelten Erfahrung formulieren sie das in einem reichen Forscherleben gesammeltes Wissen ohne Abstriche an den Erkenntniswert so, dass es von einer elementaren Basis aus zugänglich ist.

  11. Einstein und Heisenberg Begründer der modernen Physik

    CERN Document Server

    Kleinknecht, Konrad

    2017-01-01

    Dieses Buch erzählt die spannende Geschichte der großartigen Entdeckungen des 20. Jahrhunderts: der Einsteinschen Relativitätstheorie und der Heisenbergschen Quantenmechanik. Diese Entdeckungen legten die Grundlagen der heutigen Physik, ohne die unsere digitalisierte Welt der Computer, Satelliten und neuen Werkstoffe nicht möglich wäre. Konrad Kleinknecht versteht es, komplizierte physikalische Zusammenhänge verständlich zu schildern und verbindet die Geschichte der modernen Physik mit den Lebensläufen der beiden außergewöhnlichen Physiker. Er beschreibt in dieser Doppelbiographie die Gemeinsamkeiten und Gegensätze der beiden Koryphäen und zeigt, wie ihr Wirken das 20. Jahrhundert zum Jahrhundert der Physik formte.

  12. Distributed caching mechanism for various MPE software services

    CERN Document Server

    Svec, Andrej

    2017-01-01

    The MPE Software Section provides multiple software services to facilitate the testing and the operation of the CERN Accelerator complex. Continuous growth in the number of users and the amount of processed data result in the requirement of high scalability. Our current priority is to move towards a distributed and properly load balanced set of services based on containers. The aim of this project is to implement the generic caching mechanism applicable to our services and chosen architecture. The project will at first require research about the different aspects of distributed caching (persistence, no gc-caching, cache consistency etc.) and the available technologies followed by the implementation of the chosen solution. In order to validate the correctness and performance of the implementation in the last phase of the project it will be required to implement a monitoring layer and integrate it with the current ELK stack.

  13. Physik für Studenten der Natur- und Technikwissenschaften

    CERN Document Server

    Stroppe, Heribert

    1999-01-01

    Dieses bewährte Lehrbuch vermittelt in kompakter Form einen Überblick über das gesamte physikalische Grundlagenwissen. Die inhaltiche Gliederung nach den Grundmodellen der Physik : Teilchen, Kontinua, Wärme, Felder, Wellen, Quanten, und die didaktische Aufbereitung des Lehrstoffes ermöglichen eine rationelle Wissensaneignung. [...

  14. Die Leben Einsteins eine Reise durch die Geschichte der Physik

    CERN Document Server

    Fiami

    2005-01-01

    Jeder kennt die Namen Einstein, Newton oder Galilei. aber was weiss man über sie? Hier ein Porträt Einsteins anhand von sechs Meilensteinen aus der Geschichte der Physik. Einstein tritt auf als Protagonist in verschiedenen Epochen und bei verschiedenen Entdeckungen, die die Welt verändert haben.

  15. Der Quantensprung ist keine Hexerei die neue Physik für Einsteiger

    CERN Document Server

    Wolf, Fred Alan

    1986-01-01

    Eine faszinierende Reise von den Grundbegriffen der Physik bis zu den Grenzen der Naturwissenschaft und den menschlichen Vorstellungsvermögens. Dieses Buch verfolgt die Geschichte der Physik von den Beobachtungen der alten Griechen über die Entdeckungen Galileis und Newtons bis zu den erstaunlichen Theorien von Denkern wie Planck, Einstein, Bohr und Born.

  16. Hard X-ray balloon observations of compact galactic and extragalactic X-ray sources

    International Nuclear Information System (INIS)

    Staubert, R.; Kendziorra, E.; Pietsch, W.; Proctor, R.J.; Reppin, C.; Steinle, H.; Truemper, J.; Voges, W.

    1981-01-01

    A balloon program in hard X-ray astronomy (20-200 keV) is jointly pursued by the Astronomisches Institut der Universitaet Tuebingen (AIT) and the Max Planck-Institut fuer Extraterrestrische Physik in Garching (MPE). Since 1973 nine succussful balloon flights have been performed from Texas and Australia. Here results on Centaurus A and on several galactic binary X-ray sources are summarized. In particular the high energy photon spectrum of Hercules X-1 and the evidence for the cyclotron line feature which was discovered by us in 1976 is reviewed. (orig.)

  17. The Tenth International Workshop on MULTIFREQUENCY BEHAVIOUR OF HIGH ENERGY COSMIC SOURCES Palermo, Italy, 2013

    Directory of Open Access Journals (Sweden)

    Editorial, Foreword

    2014-12-01

    Full Text Available Organizing Institutions:Istituto di Astrofisica e Planetologia Spaziali IAPS-INAF, Roma, ItalyDpt de Cargas Utiles y Ciencias del Espacio, DCUCE-INTA Madrid, SpainE.O. Hulburt Center for Space Research, HCA-NRL, Washington D.C., USAMax-Planck Institut fr Extraterrestrische Physik, MPE, Garching, GermanySt. John’s College, SJC, Annapolis MD, USAInstitute für Astronomie und Astrophysik, Karls Eberhard, Universität SAND 1, Tübingen, GermanyASCR - Astronomical Institute, Ondřejov, Czech RepublicCTU - Czech Technical University, Prague, Czech Republic

  18. Die grossen Physiker und ihre Entdeckungen von den fallenden Körpern zu den Quarks

    CERN Document Server

    Segrè, Emilio

    1998-01-01

    Von Galileo Galilei bis zu Richard Feynman und Murray Gell-Mann - von den fallenden Körpern zu den Quarks: Der Physiknobelpreisträger Emilio Segre hat seine ganz persönliche Geschichte der Physik geschrieben. Er erzählt von den großen Gestalten und deren wichtigen Entdeckungen mit großer Anschaulichkeit und Lebendigkeit.

  19. Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications.

    Science.gov (United States)

    Balaji, Arunpandian; Jaganathan, Saravana Kumar; Supriyanto, Eko; Muhamad, Ida Idayu; Khudzari, Ahmad Zahran Md

    2015-01-01

    Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera, a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera-induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera-glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants.

  20. Der Begriff der Verständlichkeit in der modernen Physik (1948).

    Science.gov (United States)

    Feyerabend, Paul K

    2016-06-01

    This is a critical transcription of Paul Feyerabend's earliest extant essay "Der Begriff der Verständlichkeit in der modernen Physik" (1948) recovered from the European Forum Alpbach archives. In it, Feyerabend defends positivism as a progressive framework for scientific research in certain stages of scientific development. He argues that in physics visualizability (Anschaulichkeit) and intelligibility (Verständlichkeit) are time-conditioned concepts: what is deemed visualizable in the development of physical theories is relative to a specific historical context and changes over time. He concludes that from time to time the abandonment of visualizability is crucial for progress in physics, as it is conducive to major theory change, illustrating the point on the basis of advances in atomic theory. Copyright © 2015 Elsevier Ltd. All rights reserved.

  1. Faszinierende Physik ein bebilderter Streifzug vom Universum bis in die Welt der Elementarteilchen

    CERN Document Server

    Bahr, Benjamin; Riebe, Kristin

    2013-01-01

    Von den Rätseln der Quantenwelt bis zum Polarlicht - von Schwarzen Löchern bis zum GPS-System -von Teilchenbeschleunigern, dem Higgs und der Supersymmetrie bis zum Foucaultschen Pendel – dieses Buch bietet einen packenden Streifzug durch die spannendsten und aktuellsten Themen der modernen Physik! Auf jeweils einer Doppelseite wird dem Leser dabei mit vielen Bildern ein kompakter und klar verständlicher Einstieg in jeweils ein Thema und den Stand der Forschung geboten – und so insgesamt etwa 140 verschiedene Themen beleuchtet und jedes treffend erläutert. Dabei liegt die besondere Stärke des Buches in der klaren Sprache und den Erklärungen, die nahezu ganz ohne Formeln auskommen – begleitet von atemberaubenden und weltweit eingeholten Bildern renommierter Forscher und Institute, die uns die Schönheit unserer Welt vor Augen führen.

  2. Forskel i naturværdi mellem områder med og uden Japansk Pileurt, Kæmpe Pileurt og Rynket Rose i Aarhus Kommune

    DEFF Research Database (Denmark)

    Nielsen, Steffen Larni; Madsen, Bjarke

    2015-01-01

    Invasive arter blandt andre Japansk Pileurt, Kæmpe Pileurt og Rynket Rose, har Aarhus Kommune et særligt fokus på. Vi undersøgte floristiske forskelle mellem lokaliteter med og uden de nævnte invasive plantearter. Vi fandt, at artsrigdom og naturværdi er lavere, samt en anderledes artssammensætning...

  3. Sexl Physik 8 für die 7. und 8. Klasse der allgemein bildenden höheren Schulen (2. Teil)

    CERN Document Server

    Sexl, Roman U; Stadler, Helga; Jakesch, Peter; Sattlberger, Eva

    2013-01-01

    Dieser Band behandelt die Physik des 20. Jahrhunderts (Relativitätstheorie, Quantenmechanik, Kern- und Teilchenphysik, Kosmologie) im philosophisch-historischen Kontext. Wie in jedem Band des Lehrgangs sind übersichtliche Zusammenfassungen, Test- und weiterführende Fragen sowie Rechenbeispiele enthalten.

  4. Prevention and health promotion from theory to practice: The interprofessional MeMPE Summer University for students of Medicine, Master of Public Health and Epidemiology

    Directory of Open Access Journals (Sweden)

    Idler, Nadja

    2016-11-01

    Full Text Available Objective: During the 2015 summer semester of Munich’s Ludwig Maximilian University (LMU medical school, the pilot project “MeMPE Summer University – An Interprofessional Seminar on Prevention and Health Promotion” was implemented as a compulsory elective subject. In 90 teaching units of 45 minutes each, 20 students from the degree programs of Medicine, Master of Public Health and Master of Science Epidemiology (MeMPE completed modules in theoretical introduction, scientific project work as well as practical assignments and conference attendance.Methods: The project was evaluated by students using pre- and post-project questionnaires (26 and 57 items, evaluated on a Five-level Likert scale of 1=“fully agree” to 5=“fully disagree”. The evaluation interviews of the instruction participants were recorded, transcribed and analyzed according to Mayring’s qualitative content analysis.Results: Questionnaire response rate was 100 %. In pre/post comparison, the students reported an improvement in factual knowledge (pre median=3.0; post median=2.0; p<0.0001, in scientific work (pre median=3.0; post median=1.0; p<0.0001 and in interprofessional work (pre median=2.0; post median=1.0; p=0.024. In 18 interviews, the instructors largely expressed their motivation to participate in the project again.Conclusion: The MeMPE Summer University can serve as an example of best practice for interprofessional communication of prevention and health-promotion topics in theory and practice. The evaluation results show that the project enjoyed a high level of acceptance among students and instructors, and that it should be conducted in a revised version again in 2016.

  5. The world-line. Albert Einstein and modern physics; Die Weltlinie. Albert Einstein und die moderne Physik

    Energy Technology Data Exchange (ETDEWEB)

    Maalampi, Jukka [Jyvaeskylae Univ. (Finland). Dept. of Physics

    2008-07-01

    This book is an entertaining and formula-free presentation of modern physics from the 19th century to present. The life of Albert Einstein and his scientific works are drawn as red fathom through the text. The author explains central terms and results of modern physics in populary-scientific form from the historical perspective. To the reader in humorous form an imagination is mediated how modern physics has been developed. We learn from the exciting effects of the ether, we hear from faraday and magnetic needles, from Maxwell's prediction of the electromagnetic waves, from heinrich Hertz and from the photoelectric effect. Was the Michelson-Morley experiment a measurement success or an unsuccess? Why has Einstein abandoned the ether? How has Einstein in the miraculous year 1905 revolutionated physics and why he has begged Newton for excusement? Exist atoms? What is motion? What is light and what is to be understood under ''now'' and ''here''? Light deviation or non-deviation? How act the tidal forces? And above all: How has Einstein answered these questions. We meet Poincare, Lorentz and Hilbert, Boltzmann and Bohr, Minkowski, Planck, de Broglie, Hubble and Weyl, Gamow, Hahn and Meitner, Kapiza and Landau, Fermi and many other famous scientists. What had Eddington against Chandrasekhar and what had Einstein against black holes? Why should space tourists and dream tourists make holiday not on the Loch Ness but on the safe side of a black hole? Why inveighed Pauli against Einstein? Is the concern with the atomic-bomb formula right? Smeared matter, big bang and cosmic background radiation, gravitational waves and double pulsars, the cosmological constant and the expansion of the universe are further themes, which keep the reader in breath and let no mental vacuum arise. [German] Das Buch ist eine unterhaltsame und formelfreie Darstellung der modernen Physik vom 19. Jahrhundert bis zur Gegenwart. Das Leben Albert Einsteins

  6. Die nuklearen Anlagen von Hanford (1943-1987) Eine Fallstudie über die Schnittstellen von Physik, Biologie und die US-amerikanische Gesellschaft zur Zeit des Kalten Krieges

    Science.gov (United States)

    Macuglia, Daniele

    Die Geschichte des Kalten Krieges eröffnet viele Möglichkeiten, sich näher mit den Schnittstellen von Physik und Biologie während des 20. Jahrhunderts zu befassen. Nicht nur das Unglück in Tschernobyl aus dem Jahr 1986, auch das Beispiel der nuklearen Anlagen in Hanford in den Vereinigten Staaten zeigt die biologischen Folgen von nuklearer Physik.

  7. O perfil da relação profissional entre as empresas de serviços contábeis (ESC) e a micro e a pequena empresa (MPE)

    OpenAIRE

    Palma, Daniel Azevedo

    2005-01-01

    Neste trabalho, além do referencial teórico, envolvendo conceitos e classificações da MPE, e também da Contabilidade, realizou-se uma pesquisa de campo na cidade de Unaí -MG, em que se procurou identificar as principais características existentes na relação profissional entre as Empresas de Serviços Contábeis (ESC) e a Micro e Pequena Empresa (MPE) e verificar como as informações geradas pelas ESCs podem ser mais bem utilizadas na gestão das MPEs. Obteve-se uma amostra corroborando a caracter...

  8. A consultoria em gestão realizada pelo contabilista como alternativa de redução da mortalidade das MPE

    Directory of Open Access Journals (Sweden)

    Juarez Domingues Carneiro

    2005-03-01

    Full Text Available Este artigo tem por finalidade demonstrar que é possível reduzir a alta taxa de mortalidade das Micro e Pequenas Empresas no Brasil, na ordem de quase 50% nos dois primeiros anos, por meio da consultoria especializada em gestão, realizada por profissionais da contabilidade. O estudo tem como um de seus pilares, o estabelecimento de uma relação entre a Teoria Geral dos Sistemas e o Sistema de Gestão das Micro e Pequenas Empresas (MPE, tendo como seu subsistema principal a Consultoria em Gestão pelo Contabilista. O artigo ao mesmo tempo em que evidencia a presença constante do profissional da contabilidade nas MPE, desde o seu surgimento, também identifica uma série de causas que levam a essa mortalidade, principalmente na área de gestão, trazendo uma proposta de alternativa de redução de tal problemática, por intermédio, especialmente, da formação continuada do profissional da área contábil. This artide aims to show that it is possible to reduce the high mortality rate ofMicro and 5mall Enterprises (M5Es in Brazil, reaching almost 50% in the twofirst years, by means of consultancy, specialized in Gestion, given byaccounting professionals. One of the main fundaments of this study is theestablishment of a relationship between 5ystems General Theory and Gestion5ystem of Micro and 5mall Enterprises having as its most relevant subsystems,the Gestion Consultancy by the Accountant. Besides highlighting the frequentpresence of the Accounting Professional in the M5Es since those were firstcreated, this artide also identities series of causes that lead to theirmortality, mainly in the Gestion Area, bringing an alternative proposal ofreducing such a problem, especially through the continued education of theaccounting area professional.

  9. Posicionamento estratégico de MPE'S com base na inovação através do modelo Hélice Tríplice

    Directory of Open Access Journals (Sweden)

    Dusan Schreiber

    Full Text Available A globalização dos mercados, os avanços da ciência e da tecnologia, estimulou o surgimento de novos nichos de mercado, com consumidores mais exigentes, e, também, o aumento da competitividade entre empresas (ORTIZ, 2003. Nesse panorama, destacam-se as micro e pequenas empresas - MPE's, que se responsabilizam por parcela relevante de geração de oportunidades de emprego e de renda no país. No entanto,estudos apontam para a fragilidade técnica e produtiva das MPE'sque se reflete em índices mais elevados de encerramento de operações e de inadimplência de obrigações sociais e tributárias (SEBRAE, 2009. Esses agentes econômicos, por vezes menos preparados para competir, mas essenciais para o sistema econômico e social dos países, foram contemplados com políticas públicas, voltadas para o estímulo ao empreendedorismo, priorizando a capacitação em gestão e métodos de produção (CASSIOLATO & LASTRES, 2001. Dentre elas destacam-se a constituição de redes colaborativas de MPE's, a capacitação de seus gestores e equipes operacionais, além da disponibilização de acesso ao conhecimento técnico, com vistas a subsidiar a atividade de inovação de produtos e processos (MATTOS et al., 2009. Com o objetivo de otimizar a alocação de recursos públicos para o referido fim, os agentes governamentais optam pela adoção do modelo de Hélice Tríplice, por meio do qual o governo media a interação entre a academia e as empresas e fomenta o compartilhamento da infra-estrutura universitária, dos conhecimentos, métodos e técnicas, desde a gestão até a operação. O objetivo deste trabalho visa evidenciar as características do posicionamento estratégico de empresas de pequeno porte, que participam de duas redes de cooperação, atuantes na região sul do país, com destaque para o processo de concepção de estratégias individuais e coletivas construídas com base em programas de capacitação em inovação, de produtos e

  10. Depositional System Transition from Braided River to Tide Dominated Delta-A Case Study of the MPE3 Block in the Eastern Venezuelan Basin

    Science.gov (United States)

    Huang, Wensong; Chen, Heping; Xu, Fang; Meng, Zheng; Li, Yonghao

    2017-04-01

    The Eastern Venezuelan basin is a world-class petroliferous area, with the sedimentary environment controlled by the interaction between the Caribbean plate and the American plate. Based on interpretation of 3D seismic data, description of electrical well-logging facies and analysis of the sedimentary phenomena on the cores, we distinguished different types of sedimentary associations and clarified the evolution progress of the sedimentary system in the study area, the MPE3 Block. We put forward that depositional system in the study area changed from braided river in the early Miocene to tide dominated delta in the middle Miocene. Paralleled with sedimentary progress, the depositional hydrodynamic mechanism altered from the inertia dominated setting into the buoyancy dominated setting. During the middle Miocene, the tidal effect obviously reworked and formed tidal bars and tidal channels, both severing as the sedimentary framework. From the perspective of the tectonic movement, the study area varied from the foreland stage during the early Miocene to the compression and inverse stage during the middle Miocene. At the same time, the study area located in the southern part of the foreland basin began to extend and marine transgression occurred due to the tectonic extensional movement. We pointed out that critical factors influencing the transition from braided river to tidal dominate delta include palaeogeomorphology, sea level fluctuation, feeder system and the distance to catchment area.

  11. Auf dem Weg zur digitalen Fakultät - moderne IT Infrastruktur am Beispiel des Physik-Departments der TU München

    Science.gov (United States)

    Homolka, Josef

    Der Geschäftsbetrieb einer Universität ist durch zunehmende Digitalisierung und Nutzung elektronischer Medien gekennzeichnet. Die Einführung immer leistungsfähigerer zentraler IT-Systeme führt zu einer komplexen Vielfalt heterogener Benutzer- und Administrationsschnittstellen. Zur Schaffung einer umfassenden benutzerfreundlichen und nahtlosen IT-Infrastruktur ist die Beteiligung aller organisatorischen Einheiten und Ebenen erforderlich. Am Physik-Departement der Technischen Universität München wurden unter Integration eigener Ressourcen mit zentralen Ressourcen, die im Rahmen des IntegraTUM Projektes entwickelt und bereitgestellt wurden, existierende Dienste weiterentwickelt und neue Angebote aufgebaut. Das System, bestehend aus den Komponenten Netzwerk, Arbeitsplatzrechner, Serverinfrastruktur, E-Mail-Service, WWWDienst, Datenhaltung und Software wurde für die Nutzerkreise Studenten und Mitarbeiter im Hinblick auf Anwenderfreundlichkeit und nahtlosen Zugriff optimiert.

  12. (and Sound) of SiMPE

    DEFF Research Database (Denmark)

    Erkut, Cumhur; Jylhä, Antti; Serafin, Stefania

    application stores. As proposed in the ACM Curriculum report, these application domains are attractive in education, especially in computer science and interaction design. The main question is how to systematically integrate the rapidly evolving knowledge, know-how, tools, and techniques of mobile (audio......) programming and interaction design into university curricula. In this paper, we provide an account of our own development and teaching experience. We highlight the outcomes, which are exploratory applications challenging the state-of-the-art in mobile application development based on non-speech sound...

  13. Soft X-ray Variability of the Bright Quasar 3C273

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    on the analysis of the Einstein data, it was argued that the broken power law or power law + black body model is ... power law ( soft) is 2.7 when the photon index ( hard) of the harder power law is fixed at 1.5, and there are small but ..... J. Trümper for the kind hospitality at the Max-Planck-Institut für. Extraterrestrische Physik ...

  14. Physik 50 Experimente : 9. - 13. Schulstufe

    CERN Document Server

    Neumann, Susanne

    2015-01-01

    Dieses Buch richtet sich sowohl an Kinder und Jugendliche, die auf der Suche nach spannenden Experimenten sind, als auch an Lehrkräfte. Um den didaktischen Anspruch zu erfüllen, werden insbesonders Experimente ausgewählt, die zum Nachdenken anregen, da Phänomene gezeigt werden, die mit den Alltagsvorstellungen oft nicht vereinbar sind. Diese Beobachtungen sollen Kinder und Jugendliche nicht nur verblüffen, sondern auch motivieren nach einer Erklärung zu suchen und ihre Alltagsvorstellungen in Frage zu stellen.

  15. MPA/ESO/MPE/USM Joint Astronomy Conference

    CERN Document Server

    Böhringer, H; Finoguenov, A; Schuecker, P; Heating versus Cooling in Galaxies and Clusters of Galaxies

    2007-01-01

    The present volume is the record of a recent topical conference on the interplay between heating and cooling processes in galaxies and clusters of galaxies. The volume documents recent progress in our understanding of the dense central regions of these objects. Chapters detail recent results from multiwavelength observations and advances in numerical hydrodynamical simulations. An additional section covers new research on feedback and self-regulatory mechanisms during cosmic structure formation in general, and in galaxy formation in particular. With reviews and technical papers written by leading scientists, this state-of-the art report will be a valuable and comprehensive source of reference for all astronomers and astrophysicists active in this field.

  16. MPI fuer Physik und Astrophysik. Werner-Heisenberg-Institut fuer Physik - annual report 1983

    International Nuclear Information System (INIS)

    1983-12-01

    This annual report contains short description of the work performed at the named institute together with a list of publications and speeches. The work concerns experiments at CERN and at the storage rings PETRA and CESR, theoretical work on unified field theories and supersymmetry, as well as developments of the ALEPH detector for the LEP storage ring. (HSI) [de

  17. Light Dawns on Dark Gamma-ray Bursts

    Science.gov (United States)

    2010-12-01

    journal Astronomy & Astrophysics on 16 December 2010 The team is composed of: J. Greiner (Max-Planck-Institut für extraterrestrische Physik [MPE], Germany), T. Krühler (MPE, Universe Cluster, Technische Universität München), S. Klose (Thüringer Landessternwarte, Germany), P. Afonso (MPE), C. Clemens (MPE), R. Filgas (MPE), D.H. Hartmann (Clemson University, USA), A. Küpcü Yoldaş¸ (University of Cambridge, UK), M. Nardini (MPE), F. Olivares E. (MPE), A. Rau (MPE), A. Rossi (Thüringer Landessternwarte, Germany), P. Schady (MPE), and A. Updike (Clemson University, USA) ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 14 countries: Austria, Belgium, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the world's biggest eye on the sky".

  18. Physik gestern und heute: Visualisierung mit der Schlierenmethode

    Science.gov (United States)

    Heering, Peter

    2006-07-01

    Der Name des österreichischen Forschers Ernst Mach ist heute noch mit der Schallgeschwindigkeit verbunden. Diese Auszeichnung resultiert aus Machs Untersuchungen, wie sich Projektile mit Überschallgeschwindigkeit durch die Luft bewegen. Gerade in jüngster Zeit hat die Anwendung derartiger Methoden durch technische Modifikationen wieder einen Aufschwung erfahren.

  19. Symmetries in physics and harmonics; Symmetrien in Physik und Harmonik

    Energy Technology Data Exchange (ETDEWEB)

    Kolk, D.

    2006-07-01

    In this book the symmetries of elementary particles are described in relation to the rules of harmonics in music. The selection rules are described in connections with harmonic intervals. Also symmetry breaking is considered in this framework. (HSI)

  20. Report / Institut für Experimentelle Physik II

    OpenAIRE

    Grundmann, Marius

    2014-01-01

    The Institute for Experimental Physics II of Universität Leipzig welcomes you to read its activity report 2001. In the following some statistics about the structure of the institute, the people involved, and the teaching activities are summarized. The core of the report is built by the scientific activity reports - arranged according to the groups making up the institute: solid-state optics and acoustics, semiconductor physics, nuclear solid-state physics, physics of dielectric solids, super...

  1. Medical physics 2013. Abstracts; Medizinische Physik 2013. Abstractband

    Energy Technology Data Exchange (ETDEWEB)

    Treuer, Harald (ed.) [Koeln Univ. (Germany). Klinik fuer Stereotaxie und Funktionelle Neurochirurgie

    2013-07-01

    The proceedings of the medical physics conference 2013 include abstract of lectures and poster sessions concerning the following issues: Tele-therapy - application systems, nuclear medicine and molecular imaging, neuromodulation, hearing and technical support, basic dosimetry, NMR imaging -CEST (chemical exchange saturation transfer), medical robotics, magnetic particle imaging, audiology, radiation protection, phase contrast - innovative concepts, particle therapy, brachytherapy, computerized tomography, quantity assurance, hybrid imaging techniques, diffusion and lung NMR imaging, image processing - visualization, cardiac and abdominal NMR imaging.

  2. Big Bang 2 Physik : Schülerbuch

    CERN Document Server

    Apolin, Martin

    2016-01-01

    Physiaklisches Wissen aufbereitet in leicht verständlicher Sprache ; ausgehend von kompetenzorientierten Fragen zu interessanten Antworten ; spannende Bezüge zum Alltag mit Themen aus Sport, Biologie und Medizin.

  3. Werner-Heisenberg-Institut fuer Physik. Annual report 1982

    International Nuclear Information System (INIS)

    1982-12-01

    This annual report contains extended abstracts about the work done at the named institute together with a list of publications, speeches, seminars, and lectures. The work concerns experimental studies on high energy physics at CERN and at the PETRA storagering with the CELLO detector together with some planned experiments on the Tevatron accelerator, developments for future LEP experiments, theoretical studies on grand unification, QCD phenomenology, lattice gauge theories, supergravity, quantum mechanics, and non-relativistic many-body theory, as well as developments of radiation detectors. (HSI) [de

  4. Annual report 1980 of the Institut fuer Physik of the Max-Planck-Institut fuer Physik und Astrophysik, Muenchen

    International Nuclear Information System (INIS)

    1980-12-01

    In this annual report the fields of research done at the MPI for Physics and Astrophysics are summarized. These concern mainly high energy physics. The theoretical work deals with field theory with special regards to unified gauge theories while the Institute contributes to some experiments at DESY and CERN. Furthermore, a list of publications and theses is given. (HSI)

  5. XIPE the X-Ray Imaging Polarimetry Explorer

    Science.gov (United States)

    Soffitta, Paolo; Barcons, Xavier; Bellazzini, Ronaldo; Braga, Joao; Costa, Enrico; Fraser, George W.; Gburek, Szymon; Huovelin, Juhani; Matt, Giorgio; Pearce, Mark; hide

    2013-01-01

    .7 arcmin 14.7 arcmin. The spectral resolution is 20 at 6 keV and the time resolution is 8 s. The imaging capabilities of the JET-X optics and of the GPD have been demonstrated by a recent calibration campaign at PANTER X-ray test facility of the Max-Planck-Institut fr extraterrestrische Physik (MPE, Germany). XIPE takes advantage of a low-earth equatorial orbit with Malindi as down-link station and of a Mission Operation Center (MOC) at INPE (Brazil). The data policy is organized with a Core Program that comprises three months of Science Verification Phase and 25 of net observing time in the following 2 years. A competitive Guest Observer program covers the remaining 75 of the net observing time.

  6. Measurement of the diffuse atmospheric and cosmic γ-radiation in the energy range 1-10 MeV by a balloon carried Compton-telescope

    International Nuclear Information System (INIS)

    Lichti, G.

    1975-01-01

    The operation and design of a low-energy γ-compton telescope, developed and constructed at the Max-Planck-Institut fuer extraterrestrische Physik, are reported on. For energies of about 1 MeV, the telescope has an energy resolution of 30% (FWHM) and an angular resolution of +- 20 0 . In spite of the low efficiency of only about 0.5%, the vertical γ-flux could be measured for the first time in two balloon flights, and the extragalactic origin of the diffuse component of the cosmic γ-radiation could be demonstrated. The energy spectrum of this radiation was measured. The result is compared with measurements of other experiments, and theoretical models to describe the origin of this radiation are discussed. (orig.) [de

  7. VizieR Online Data Catalog: Rest frequencies of dithioformic acid (Prudenzano+, 2018)

    Science.gov (United States)

    Prudenzano, D.; Laas, J.; Bizzocchi, L.; Lattanzi, V.; Endres, C.; Giuliano, B. M.; Spezzano, S.; Palumbo, M. E.; Caselli, P.

    2018-01-01

    The measurements were performed using the CASAC (Center for Astrochemical Studies Absorption Cell) spectrometer at the Max-Planck-Institut fuer extraterrestrische Physik. Full details of the experimental apparatus can be found in Bizzocchi et al. (2017A&A...602A..34B). The instrument employs the frequency modulation technique in the mm and submm range and is equipped with a glow discharge cell for production of unstable species. Measurements were carried out at room temperature to avoid condensation of the precursors. Dithioformic acid was produced by a 40mA DC discharge (~0.8kV) from a 1:1 mixture of CS2 and H2, diluted in Ar buffer gas. The total pressure in the cell was 20-30mTorr (27-40ubar). (4 data files).

  8. Some applications of nanometer scale structures for current and future X-ray space research

    DEFF Research Database (Denmark)

    Christensen, Finn Erland; Abdali, S; Frederiksen, P K

    1994-01-01

    Nanometer scale structures such as multilayers, gratings and natural crystals are playing an increasing role in spectroscopic applications for X-ray astrophysics. A few examples are briefly described as an introduction to current and planned applications pursued at the Danish Space Research...... Institute in collaboration with the FOM Institute for Plasma Physics, Nieuwegein, the Max-Planck-Institut für Extraterrestrische Physik, Aussenstelle Berlin, the Space Research Institute, Russian Academy of Sciences, the Smithsonian Astrophysical Observatory, Ovonics Synthetic Materials Company and Lawrence...... Livermore National Laboratory. These examples include : 1. the application of multilayered Si crystals for simultaneous spectroscopy in two energy bands one centred around the SK-emission near 2.45 keV and the other below the CK absorption edge at 0.284 keV; 2. the use of in-depth graded period multilayer...

  9. Heidelberg physicists report. Vol. 1. Reviews of research in physics and astronomy. Ways to the modern physics; Heidelberger Physiker berichten. Bd. 1. Rueckblicke auf Forschung in der Physik und Astronomie. Wege zur modernen Physik

    Energy Technology Data Exchange (ETDEWEB)

    Appenzeller, Immo; Dubbers, Dirk; Siebig, Hans-Georg; Winnacker, Albrecht (eds.)

    2017-07-01

    The following topics are dealt with: Memories of the physics from 1945 until 1970, from the atomic nucleus until the fission of uranium, the emergence of the physics of the atomic nuclei, 43 years of elementary-particle physics, 60 years of research, elementary particles and forces of physics. (HSI)

  10. The Most Distant Mature Galaxy Cluster - Young, but surprisingly grown-up

    Science.gov (United States)

    2011-03-01

    information This research was presented in a paper, "A mature cluster with X-ray emission at z = 2.07", by R. Gobat et al., published in the journal Astronomy & Astrophysics. The team is composed of R. Gobat (Laboratoire AIM-Paris-Saclay, France), E. Daddi (AIM-Paris), M. Onodera (ETH Zürich, Switzerland), A. Finoguenov (Max-Planck-Institut für extraterrestrische Physik [MPE], Garching, Germany), A. Renzini (INAF-Osservatorio Astronomico di Padova), N. Arimoto (National Astronomical Observatory of Japan), R. Bouwens (Lick Observatory, Santa Cruz, USA), M. Brusa (MPE), R.-R. Chary (California Institute of Technology, USA), A. Cimatti (Università di Bologna, Italy), M. Dickinson (NOAO, Tucson, USA), X. Kong (University of Science and Technology of China), and M.Mignoli (INAF - Osservatorio Astronomico di Bologna, Italy). ESO, the European Southern Observatory, is the foremost intergovernmental astronomy organisation in Europe and the world's most productive astronomical observatory. It is supported by 15 countries: Austria, Belgium, Brazil, the Czech Republic, Denmark, France, Finland, Germany, Italy, the Netherlands, Portugal, Spain, Sweden, Switzerland and the United Kingdom. ESO carries out an ambitious programme focused on the design, construction and operation of powerful ground-based observing facilities enabling astronomers to make important scientific discoveries. ESO also plays a leading role in promoting and organising cooperation in astronomical research. ESO operates three unique world-class observing sites in Chile: La Silla, Paranal and Chajnantor. At Paranal, ESO operates the Very Large Telescope, the world's most advanced visible-light astronomical observatory and VISTA, the world's largest survey telescope. ESO is the European partner of a revolutionary astronomical telescope ALMA, the largest astronomical project in existence. ESO is currently planning a 42-metre European Extremely Large optical/near-infrared Telescope, the E-ELT, which will become "the

  11. "Heart" of Herschel to be presented to media

    Science.gov (United States)

    2007-09-01

    instruments were designed and built by consortia of scientists and institutes, with their own national funding. The Photodetector Array Camera and Spectrometer (PACS) was developed under the coordination of the MPE, Germany; the Spectral and Photometric Imaging Receiver (SPIRE) was developed under the coordination of the Cardiff University (United Kingdom); the Heterodyne Instrument for the Far Infrared (HIFI) was developed under the coordination of the SRON institute (The Netherlands). For more information ESA Media Relations Office Tel: +33(0)1.53.69.7299 Fax: +33(0)1.53.69.7690 Herschel Press Day at Astrium, Friedrichshafen, Germany 19 September 2007 Claude-Dornier-Strasse 88090 Immenstaad 09:00 h Arrival at Astrium /Check-in / Transfer to Building 8 / Room Meersburg (5 th floor) 09:30 h Welcome, by Uwe Minne, Director of Earth Observation and Science, Astrium 09:35 h ESA and Astronomy: looking forward, by Jacques Louet, Head of Scientific Projects Department, ESA 09:45 h Herschel/Planck mission overview, by Thomas Passvogel, ESA Herschel/Planck Project Manager 09:55 h The Herschel scientific mission, by Göran Pilbratt, ESA Herschel Project Scientist 10:05 h Q & A followed by coffee break 10:30 h Herschel spacecraft overview, by Jean-Jacques Julliet, Director of European Science and Optical Observation Programmes, Thales Alenia Space 10:40 h The ‘cool’ heart of Herschel, by Wolfgang Fricke, Herschel Project Manager, Astrium 10:50 h The PACS instrument, by Albrecht Poglitsch, Principal Investigator, Max-Planck-Institut für extraterrestrische Physik (MPE) 11:00 h The SPIRE instrument, by Matthew Griffin, Principal Investigator, Cardiff University 11:10 h The HIFI instrument, by Thijs de Graauw, Principal Investigator, Netherlands Institute for Space Research (SRON) 11:20 h Q & A, Individual Interviews 12:15 h Transfer to Integration Centre 12:30 h Warm / Cold Buffet on Visitoŕs Galaxy Build up of three different visitor groups Check-in into cleanroom Photo

  12. Exportações brasileiras: fatores explicativos da participação das micro e pequenas empresas (MPE)

    OpenAIRE

    Fernando Martinson Ruiz

    2005-01-01

    As micro e pequenas empresas (MPEs), foco desta pesquisa, apresentam características peculiares em comparação às empresas de maior porte. O número de MPEs brasileiras, industriais e exportadoras vem aumentando nos últimos anos, assim como a continuidade de suas atividades exportadoras, configurando um novo panorama para este tipo de empresas. A participação destas empresas no volume de exportação total do país ainda é muito pequena (aproximadamente 2,4%, em 2003), para padrões internacionais ...

  13. Annual report on research and development 1980 of the Institut fuer Technische Physik

    International Nuclear Information System (INIS)

    1981-06-01

    Progress of the following working areas of the institute is reported: magnets for fusion technology (TESPE experiment, the Large Coil Task (LCT)); components and technology (development of high field superconductors (Nb 3 Sn, Nb 3 Al)), cooling techniques (HELITEX experiment); system studies on fusion reactor components; magnets for research and technology; basic research related to superconductivity; cryo-energy technology; the cryogenic engineering infrastructure of the institute. (GSCH)

  14. Results of research and development work in 1982 of the Institut fuer Technische Physik

    International Nuclear Information System (INIS)

    1983-02-01

    The works in the Institute for Technical Physics (ITP) concentrated in 1982 upon the application of high current superconductivity in the fields of energy engineering and fusion. Moreover, the magnet technology for use in other fields of research and technology is advanced. Fundamental investigations on cryogenics and superconductors as well as studies go along with the technical research program. The magnetic fields of stationary and quasi-stationary fusion reactors with magnetic confinement have to be produced by superconductivity. The aim of the magnet developments in the KfK is therefore to make available the technology of superconductivity for large-scale experiments in plasma physics and the later fusion reactors, which is performed in co-operation with industry as part of the European fusion program. (orig./GG) [de

  15. Basic course in theoretical physics. Vol. 2. Grundkurs in Theoretischer Physik. Bd. 2

    Energy Technology Data Exchange (ETDEWEB)

    Dietze, H D

    1975-01-01

    This book is the second volume of an edition of two volumes which concern theoretical physics. In this volume electrodynamics, the foundations of special relativity theory, and elementary quantum mechanics are introduced.

  16. Max-Planck-Institut fuer Physik. Werner-Heisenberg-Institut. Annual report 1993

    International Nuclear Information System (INIS)

    1994-03-01

    The Institute's main field of activity is research into elementary particles and their interactions. The verification of the standard model of elementary particle physics was at the center of interest in the phenomenological investigations. The spectrum of experimental activities on particle accelerators is supplemented by experiments on astro-particle physics and cosmic sources. Segmented semiconductor detectors were developed for investigations in high-energy physics. The 1993 annual report also contains organisational and staff data and a survey of activities. (DG) [de

  17. 9th scientific meeting of the Deutsche Gesellschaft fuer Medizinische Physik e.V

    International Nuclear Information System (INIS)

    1978-01-01

    Contributions to the radiation protection problem, taking into account the radiation protection ordinance, recently developed radiographic methods in medical diagnostics, especially with regard to automation of the imaging technique, and contributions to radiation therapy with regard to apparatus and equipment are discussed. (VJ) [de

  18. Max-Planck-Institut fuer Physik. Werner-Heisenberg-Institut. Annual report 1994

    International Nuclear Information System (INIS)

    1995-05-01

    After a short introduction, the projects and activitites of the scientific and technical departments are presented. The spectrum of theoretical studies ranges from problems of particle physics and field theory to astrophysical problems. The experimental activities focus mainly on accelerated particles and detectors for high-energy physics. The 1994 annual report also contains staff reports and reports on general activities in the year under report. (DG) [de

  19. Letters on nuclear controversy. Streitbriefe ueber Kernenergie. Zwei Physiker ueber Wissenschaft, Fortschritt und die Folgen

    Energy Technology Data Exchange (ETDEWEB)

    Kafka, P; Maier-Leibnitz, H

    1982-01-01

    Heinz Maier-Leibnitz a well-known scientist, nuclear physicist, for 50 years, who publicily supported the idea not to overrate the dangers of peaceful utilization of nuclear energy, has grown tired of talking only to colleagues. He invites a junior fellow physicist, who held engaged speeches against the nuclear power plant Zwentendorf, to an exchange of thoughts. Peter Kafka, an astro-physicist studied the self organisation of the universe from the big bang to the economic crisis and encountered the question of which conditions have to be fulfilled to prevent progress from becoming caranogenous. He became one of the spokesmen of 'political ecology' and called for resistance again large-scale technological use of scientific knowledge. He was enthusiastic about the idea of an exchange of letters, because he - just like his partner - believes in gaining knowledge by discussion. The variety of subjects is sketched briefly in form of three lectures. In the letters both scientists discuss intensly about: - Freedom of science and responsibility of science. - Decisions on energy questions under time-pressure. - Risks of nuclear plants. - Large scale technology and large-scale research or decentralization. - Energy utilization and energy waste. - Nuclear energy and alternatives. - Sense and nonsense of detailed future planning. In the end no one has convinced the other. The reader however finds a lot of new incentives in the letters - printed in unabridged form - a lot of new and significant arguments for a discussion which has only just started.

  20. DEGRO 2009. Radiation oncology - medical physics - radiation biology. Abstracts; DEGRO 2009. Radioonkologie - Medizinische Physik - Strahlenbiologie. Abstracts

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-06-15

    The special volume of the journal covers the abstracts of the DEGRO 2009 meeting on radiation oncology, medical physics, and radiation biology, covering the following topics: seldom diseases, gastrointestinal tumors, radiation reactions and radiation protection, medical care and science, central nervous system, medical physics, the non-parvicellular lung carcinomas, ear-nose-and throat, target-oriented radiotherapy plus ''X'', radio-oncology - young academics, lymphomas, mammary glands, modern radiotherapy, life quality and palliative radiotherapy, radiotherapy of the prostate carcinoma, imaging for planning and therapy, the digital documentation in clinics and practical experiences, NMR imaging and tomography, hadrons - actual status in Germany, urinal tract oncology, radiotoxicity.

  1. C. F. v. Weizsaecker. Physicist, philosopher, visionary; C. F. v. Weizsaecker. Physiker, Philosoph, Visionaer

    Energy Technology Data Exchange (ETDEWEB)

    Goernitz, Thomas

    2012-11-01

    The 20th century with its political, social, and scientific aspects bundles itself in the life of Carl Friedrich v. Weizsaecker. As comprehensive thinker of the presence he led natural science, philosophy, and spirituality to a unity. In the public the grandson of last in Germany enobled minster and brother of the senior federal president achieved by his engagement for peace and disarmament a global effect. Competently and understandably his visionary and prospective physical ideas and his philosophical considerations are explained by his long standing coworker and close confident.

  2. Calculation of hadronic transition amplitudes in charm physics; Berechnung hadronischer Uebergangsamplituden in der Charm-Physik

    Energy Technology Data Exchange (ETDEWEB)

    Klein, Christoph

    2011-09-23

    Transitions of charmed hadrons are of significant importance, since they provide possibilities to extract the CKM matrix elements V{sub cd} and V{sub cs} from experimental data as well as interesting channels to search for new physics effects. However, quarks are bound in hadrons, and it is necessary to describe this effect in a reliable way, to study the underlying flavour dynamics. For this, one has to use nonperturbative tools, to determine the corresponding transition amplitudes. The results of such calculations can furthermore be of use, to test the predictions of QCD and to contribute to a deeper understanding of the structure of hadrons. In this thesis two topics are investigated using the method of QCD light-cone sum rules (LCSRs). The first topic consists in the form factors of the semileptonic decays D {yields} {pi}l{nu}{sub l} and D {yields} Kl{nu}{sub l}, for which new results are calculated using up-to-date input values. Since LCSRs are not applicable in the whole range of kinematics, they are extrapolated by the use of appropriate parametrisations and the results agree well with experimental data. The second topic are the transitions of charmed baryons to a nucleon. Here the corresponding transition form factors and in addition the hadronic {lambda}{sub c}D{sup (*)}N and {sigma}{sub c}D{sup (*)}N coupling constants are calculated - the latter by the consideration of double dispersion relations. These coupling constants are of special interest for the description of hadronic interactions, like open charm production in proton-antiprotoncollisions. Furthermore there appears the problem, that both parity states of a baryon contribute to the considered functional representation, for which a consistent way to separate them is presented. (orig.)

  3. Physics and radiology for nursing staff. Physik und Strahlenkunde fuer Krankenpflegeberufe

    Energy Technology Data Exchange (ETDEWEB)

    Goretzki, G

    1984-01-01

    As nurses working in hospitals and surgeries as well as other assistants regularly operate technical equipment, it is essential to explain the physical basics in a form which is comprehensible to them. The author has managed to give a very clear portrayal of each area of physics with close reference to its application in medicine, partly with the use of simplified models. His portrayal extends from the make-up of the material to atomic and nuclear physics and covers mechanics, heat and electricity theory, optics and acoustics. The explanation is completed by sections on radiography and radiation protection.

  4. On the identity of the physikós quoted in col. IV of Derveni papyrus

    Directory of Open Access Journals (Sweden)

    Carlos Megino

    2014-06-01

    Full Text Available I try to establish who is the philosopher or, if he is not found, the philosophical movement, who satisfies the doctrine about prayer and chance, that the Derveni papyrus’ author attributes to the «physicus» quoted in column IV, so that this philosopher can probably be identified with this physicus. In this context, I discuss the possibility, defended by Ferrari, of the physicus in question being Democritus, and I give complementary arguments in favor of this hypothesis.

  5. X-rays Provide a New Way to Investigate Exploding Stars

    Science.gov (United States)

    2007-05-01

    The European Space Agency's X-ray observatory XMM-Newton has revealed a new class of exploding stars - where the X-ray emission 'lives fast and dies young'. The identification of this particular class of explosion gives astronomers a valuable new constraint to help them understand stellar explosions. Exploding stars called novae remain a puzzle to astronomers. "Modelling these outbursts is very difficult," says Wolfgang Pietsch, Max Planck Institut für Extraterrestrische Physik. Now, ESA's XMM-Newton and NASA's Chandra have provided valuable information about when individual novae emit X-rays. Between July 2004 and February 2005, the X-ray observatories watched the heart of the nearby Andromeda Galaxy, known to astronomers as M31. During that time, Pietsch and his colleagues monitored novae, looking for the X-rays. X-ray Image of Andromeda Galaxy (M31) Chandra X-ray Image of Andromeda Galaxy (M31) They detected that eleven out of the 34 novae that had exploded in the galaxy during the previous year were shining X-rays into space. "X-rays are an important window onto novae. They show the atmosphere of the white dwarf," says Pietsch. White dwarfs are hot stellar corpses left behind after the rest of the star has been ejected into space. A typical white dwarf contains about the mass of the Sun, in a spherical volume little bigger than the Earth. It has a strong pull of gravity and, if it is in orbit around a normal star, can rip gas from it. This material builds up on the surface of the white dwarf until it reaches sufficient density to nuclear detonate. The resultant explosion creates a nova. However, these particular events are not strong enough to destroy the underlying white dwarf. The X-ray emission becomes visible some time after the detonation, when the matter ejected by the nova thins out enough to allow astronomers to peer down to the nuclear burning white dwarf atmosphere beneath. At the end of the process, the X-ray emission stops when the fuel is

  6. Fabrication, test and performance of very large X-ray CCDs designed for astrophysical applications

    CERN Document Server

    Soltau, H; Meidinger, N; Stoetter, D; Strüder, L; Trümper, J E; Zanthier, C V; Braeuniger, H; Briel, U; Carathanassis, D; Dennerl, K; Engelhard, S; Haberl, F; Hartmann, R; Hartner, G; Hauff, D; Hippmann, H; Holl, P; Kendziorra, E; Krause, N; Lechner, P; Pfeffermann, E; Popp, M; Reppin, C; Seitz, H; Solc, P; Stadlbauer, T; Weber, U; Weichert, U

    2000-01-01

    A 6x6 cm sup 2 large X-ray CCD has been developed and fabricated at the Semiconductor Laboratory of the Max-Planck-Institut fuer Extraterrestrische Physik. The CCD has been designed for the focal plane cameras of two satellite missions. The concept is a fully depleted pn-CCD which is sensitive over the whole wafer thickness of about 300 mu m. It has been especially developed for X-ray detection delivering a high quantum efficiency over the energy range between 0.2 and 15 keV. A production yield of 27% was achieved. Seven good (almost) defect-free wafers were produced within the performance requirements, i.e. for temperatures below 180 K they show a homogeneous noise level smaller than 5 e sup - , a uniform spectral response with an energy resolution of 130 eV for Mn-K subalpha and a reduction of the sensitive area due to defects by less than 0.3%. Three CCDs have now been integrated in the flight cameras. The presentation comprises special aspects related with the fabrication of very large CCDs, a summary of ...

  7. Physical chemistry. Pt. 3. Physikalische Chemie. T. 3. Mischphasenthermodynamik, Elektrochemie, Reaktionskinetik. Lehrbuch fuer Chemiker, Verfahrenstechniker, Physiker ab 3. Semester

    Energy Technology Data Exchange (ETDEWEB)

    Barrow, G M

    1977-01-01

    The text-book contains chapters about solids, liquids, phase diagrams of one- and multi-component systems, mixed phase thermodynamics and phase equilibria, electrolyte solutions, the EMF of electrochemical cells, macromolecules, chemical kinetics, adsorption and heterogeneous catalysis.

  8. 46. Annual meeting of the German Society for Medical Physics. Abstracts; 46. Jahrestagung der Deutschen Gesellschaft fuer Medizinische Physik. Abstractband

    Energy Technology Data Exchange (ETDEWEB)

    Fiebich, Martin [Technische Hochschule Mittelhessen, Giessen (Germany). Inst. fuer Medizinische Physik und Strahlenschutz; Zink, Klemens (ed.) [Technische Hochschule Mittelhessen, Giessen (Germany). Inst. fuer Medizinische Physik und Strahlenschutz; Universitaetsklinikum Giessen-Marburg, Marburg (Germany). Klinik fuer Strahlentherapie und Radioonkologie

    2015-07-01

    The abstracts volume of the 46th annual meeting of the German Society for Medical Physics includes abstracts on the following issues: audiology; particle therapy: dosimetric and biological aspects; functional and molecular imaging; computerized tomography; dosimetry: 2D dosimetry and clinical dosimetry; MR imaging: cardio and lungs imaging; quality assurance in radiation therapy; brachytherapy/IORT; irradiation planning; functional and molecular imaging: methodic principles; dosimetry: dosimetric base data and Monte Carlo; adaptive and guided radiation therapy; irradiation planning; laser accelerated protons; brachytherapy/IORT: dosimetry; particle therapy: irradiation planning and imaging; stereotaxis and radiosurgery; radiation protection; dosimetry: detectors and small photon fields; MRT and MRS - neuroimaging; particle therapy: in vivo verification.

  9. Physics for students of medicine and natural sciences. Physik fuer Mediziner und Naturwissenschaftler. Mit Schluessel zum Gegenstandskatalog

    Energy Technology Data Exchange (ETDEWEB)

    Breuer, H

    1978-01-01

    This textbook deals with the physics subjects of interest to students of medicine and biology. The author endeavoured to explain the physical and chemical fundamentals and their interrelationships as clearly as possible on the basis of didactically descriptive examples.

  10. Review of results of research and development work carried out by the Institut fuer Technische Physik in 1983

    International Nuclear Information System (INIS)

    1984-02-01

    At the Institute for Technical Physics (ITP), the emphasis of the studies lies with the application of full-load superconductivity, the main tasks being part of the nuclear fusion project. Additionally, magnet technology for applications in other fields of research and development is advanced. The technical research programme goes together with fundamental research in the fields of cryogenics and superconductors as well as with related studies. (orig./RW) [de

  11. The physicist. Max Planck and the decay of the world; Der Physiker. Max Planck und das Zerfallen der Welt

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Ernst Peter

    2010-06-15

    The live of the physicist Max Planck was as exciting, conflicting, and rich on catastrophes as the epoch, in which he lived. Ernst Peter Fischer draws in this fascinatingly told biography the eventful history of the Nobel-price bearer and illustrates simultaneously the unique attainment of Planck, the quantum theory of whom not only revolted the science but also changed fundamentally our picture of the world.

  12. Revolutions in twentieth-century physics; Einfuehrung in die Physik des 20. Jahrhunderts. Relativitaetstheorie, Quantenmechanik, Elementarteilchenphysik und Kosmologie

    Energy Technology Data Exchange (ETDEWEB)

    Griffiths, David J. [Reed College, Portland, OR (United States). Howard-Vollum-Professur fuer Naturwissenschaften

    2015-07-01

    Relativity theory, quantum mechanics, elementary-particle physics, and cosmology are the four pillars of modern physics. The life in the 21th century is without them no more conceivable: The special relativity theory renewed our understanding of space and time, on the laws of quantum mechanics are based countless everyday objects like transistors, computer chips, and mobile telephones; in particle accelerators we study the components oof matter, and with telescopes we take an ever deeper look in the past of the universe. Taking reference books to these themes at hand, one is overwhelmed by the plethora and complexity of the mathematical formulas. This book of the renowned professor of physics David J. Griffiths id refreshingly different. By means of many illustrative examples and entertaining stories it introducts to the themes and helps the reader also without a large mathematical apparatus to a fundamental understanding of that, about which Einstein, Schroedinger, Heisenberg, and Hubble actually thought and spoke. In each chapter numerous, pedagogically selected examples are completely worked out, in order to fill the matter with life. Moreover the text contains a manifold of problems, which allow the reader to deepen his knowledge and apply immediately. Griffith's ''Revolution in Twentieth Century Physics'' appeals not only to pupils and future studyings of natural sciences, who want to get an appetite for what lies ahead, but also to interested readers, which have already heared in the media from quarks and quanta, the curved space-time, Albert Einstein, and the big bang and now want to understandably know what is at stake in all the excitement.

  13. Feynman and physics. Life and research of an exceptional man; Feynman und die Physik. Leben und Forschung eines aussergewoehnlichen Menschen

    Energy Technology Data Exchange (ETDEWEB)

    Resag, Joerg

    2018-04-01

    The life of Feynman is described together with his work on path integrals, quantum electrodynmaics, helium at low temperatures, the weak interaction, the quark model, and computer-calculation methods, and his contribution to the Manhattan project. (HSI)

  14. From physics to metaphysics. Physical unification and string approach; Von der Physik zur Metaphysik. Physikalische Vereinheitlichung und Stringansatz

    Energy Technology Data Exchange (ETDEWEB)

    Hedrich, R.

    2007-07-01

    In spite the string approach as attempt of a nomologically unified comprehension of all interactions inclusively the gravitation exists already over three decades the physical principles on which it is based are yet completely unclear; and not the most unimportant empirically provable quantitative prediction exists. Without empirical data, which would be incompatible with the stablished theories - quantum-field theoretical standard model anf general relativity - only the conceptual incompatibility of both together with the unification idea yields a motivation for the string approach. By this however physics threatens to exceed under consequent continuation of their hitherto successful strategies the methodological framework of empirical sciences.

  15. Growing Black Holes: Accretion in a Cosmological Context Proceedings of the MPA/ESO/MPE/USM Joint Astronomy Conference Held at Garching, Germany, 21-25 June 2004

    CERN Document Server

    Merloni, Andrea; Sunyaev, Rashid A

    2005-01-01

    Supermassive black holes are now believed to play an important role in the evolution of the Universe. Every respectable galaxy hosts in its center a black hole that appears to regulate the growth of the galaxy itself. In this book, leading experts in the field review the most recent theoretical and observational results on the following topics: * formation and growth of the first black holes in the Universe and their role in the formation and evolution of galaxies * the physics of black-hole accretion and the production of relativistic jets * binary black-hole mergers and gravitational radiation. Theoretical work is supplemented by the most recent exciting results from space and ground based observatories. This volume is useful research and reference tool for the entire astrophysical community.

  16. Heidelberg physicists report. Vol. 2. Reviews of research in physics and astronomy. Fundamental contributions to the physics of the atomic nuclei and the star atmospheres; Heidelberger Physiker berichten. Bd. 2. Rueckblicke auf Forschung in der Physik und Astronomie. Grundlegende Beitraege zur Physik der Atomkerne und der Sternatmosphaeren

    Energy Technology Data Exchange (ETDEWEB)

    Appenzeller, Immo; Dubbers, Dirk; Siebig, Hans-Georg; Winnacker, Albrecht (eds.)

    2018-04-01

    The following topics are dealt with: 50 years theoretical astrophysics, nuclear physics after the discovery of the shell model, from the small van de Graaf to the large HERA, from ''chamber physics'' to big research, reminiscences on physical research in Heidelberg. (HSI)

  17. SINFONI Opens with Upbeat Chords

    Science.gov (United States)

    2004-08-01

    Dutch Institutes and ESO who have worked on the development of SINFONI for nearly 7 years. The work on SINFONI at Paranal included successful commissioning in June 2004 of the Adaptive Optics Module built by ESO, during which exceptional test images were obtained of the main-belt asteroid (22) Kalliope and its moon. Moreover, the ability was demonstrated to correct the atmospheric turbulence by means of even very faint "guide" objects (magnitude 17.5), crucial for the observation of astronomical objects in many parts of the sky. SPIFFI - SPectrometer for Infrared Faint Field Imaging - was developed at the Max Planck Institute for Extraterrestrische Physik (MPE) in Garching (Germany), in a collaboration with the Nederlandse Onderzoekschool Voor Astronomie (NOVA) in Leiden and the Netherlands Foundation for Research in Astronomy (ASTRON), and ESO. PR Photo 24a/04: SINFONI Adaptive Optics Module at VLT Yepun (June 2004) PR Photo 24b/04: SINFONI at VLT Yepun, now fully assembled (July 2004) PR Photo 24c/04: "First Light" image from the SINFONI Adaptive Optics Module PR Photo 24d/04: AO-corrected Image of a 17.5-magnitude Star PR Photo 24e/04: SINFONI undergoing Balancing and Flexure Tests at VLT Yepun PR Photo 24f/04: SINFONI "First Light" Spectrum of HD 130163 PR Photo 24g/04: Members of the SINFONI Adaptive Optics Module Commissioning Team PR Photo 24h/04: Members of the SPIFFI Commissioning Team PR Photo 24i/04: The Principle of Integral Field Spectroscopy (IFS) PR Photo 24j/04: The Orbital Motion of Linus around (22) Kalliope PR Photo 24k/04: SINFONI Observations of the Galactic Centre Region PR Photo 24l/04: SINFONI Observations of the Circinus Galaxy PR Photo 24m/04: SINFONI Observations of the AGN Galaxy NGC 7469 PR Photo 24n/04: SINFONI Observations of NGC 6240 PR Photo 24o/04: SINFONI Observations of the Young Starforming Galaxies BX 404/405 PR Video Clip 07/04: The Orbital Motion of Linus around (22) Kalliope SINFONI: A powerful and complex instrument ESO PR Photo

  18. THE IMAGING PROPERTIES OF THE GAS PIXEL DETECTOR AS A FOCAL PLANE POLARIMETER

    Energy Technology Data Exchange (ETDEWEB)

    Fabiani, S.; Costa, E.; Del Monte, E.; Muleri, F.; Soffitta, P.; Rubini, A. [INAF-IAPS, via del Fosso del Cavaliere 100, I-00133 Roma (Italy); Bellazzini, R.; Brez, A.; De Ruvo, L.; Minuti, M.; Pinchera, M.; Sgró, C.; Spandre, G. [INFN Sezione di Pisa, Largo B. Pontecorvo, 3, I-56127 Pisa (Italy); Spiga, D.; Tagliaferri, G.; Pareschi, G.; Basso, S.; Citterio, O. [INAF-Osservatorio Astronomico di Brera, via Brera 28, I-20121 Milano (Italy); Burwitz, V.; Burkert, W., E-mail: sergio.fabiani@iaps.inaf.it [Max-Planck-Institut für extraterrestrische Physik, Gautinger Str. 45, D-82061 Neuired (Germany); and others

    2014-06-01

    X-rays are particularly suited to probing the physics of extreme objects. However, despite the enormous improvements of X-ray astronomy in imaging, spectroscopy, and timing, polarimetry remains largely unexplored. We propose the photoelectric polarimeter Gas Pixel Detector (GPD) as a candidate instrument to fill the gap created by more than 30 yr without measurements. The GPD, in the focus of a telescope, will increase the sensitivity of orders of magnitude. Moreover, since it can measure the energy, the position, the arrival time, and the polarization angle of every single photon, it allows us to perform polarimetry of subsets of data singled out from the spectrum, the light curve, or an image of the source. The GPD has an intrinsic, very fine imaging capability, and in this work we report on the calibration campaign carried out in 2012 at the PANTER X-ray testing facility of the Max-Planck-Institut für extraterrestrische Physik of Garching (Germany) in which, for the first time, we coupled it with a JET-X optics module with a focal length of 3.5 m and an angular resolution of 18 arcsec at 4.5 keV. This configuration was proposed in 2012 aboard the X-ray Imaging Polarimetry Explorer (XIPE) in response to the ESA call for a small mission. We derived the imaging and polarimetric performance for extended sources like pulsar wind nebulae and supernova remnants as case studies for the XIPE configuration and also discuss possible improvements by coupling the detector with advanced optics that have a finer angular resolution and larger effective areas to study extended objects with more detail.

  19. Structure of the low-latitude boundary layer

    International Nuclear Information System (INIS)

    Sckopke, N.; Paschmann, G.; Haerendel, G.; Sonnerup, B.U.O.; Bame, S.J.; Forbes, T.G.; Hones, E.W. Jr.; Russell, C.T.

    1981-01-01

    Observations at high temporal resolution of the frontside magnetopause and plasma boundary layer, made with the Los Alamos Scientific Laboratory/Max-Planck-Institut, Institut fuer Extraterrestrische Physik, fast plasma analyzer on board the Isee 1 and 2 spacecraft, have revealed a complex quasi-periodic structure of some of the observed boundary layers: cool tailward streaming boundary layer plasma is seen intermittently, with intervening periods of hot tenuous plasma which has properties similar to the magnetospheric population. While individual encounters with the boundary layer plasma last only a few minutes, the total observation time may extend over 1 hour or more. One such crossing, at 0800 hours local time and 40 0 northern GSM latitude, is examined in detail, including a quantitative comparison of the boundary layer entry and exit times of the two spacecraft. The data are found to be compatible with a boundary layer that is always attached to the magnetopause but where the layer thickness has a large-scale spatial modulation pattern which travels tailward past the spacecraft. Included are periods when the thickness is essentially zero and others when it is of the order of 1 R/sub E/. The duration of these periods is highly variable but is typically in the range of 2--5 min, corresponding to a distance along the magnetopause of the order of 3--8 R/sub E/. The observed boundary layer features include a steep density gradient at the magnetopause, with an approximately constant boundary layer plasma density amounting to about 25% of the magnetosheath density, and a second abrupt density decrease at the inner edge of the layer. It also appears that the purely magnetospheric plasma is ocassionally separated from the boundary layer by a halo region in which the plasma density is somewhat higher, and the temperature somewhat lower, than in the magnetosphere. A tentative model is proposed

  20. Shape theory. Functional connections of information, energy, and temperature in phasics and physiology; Gestalttheorie. Funktionelle Zusammenhaenge von Information, Energie und Temperatur in Physik und Physiologie

    Energy Technology Data Exchange (ETDEWEB)

    Wengel, Claus

    2012-11-01

    Starting from the phenomenon of the information input and the information output system in the central nervous system, which was conceived in physiology, as well as from the phenomenon of the disturbance oc consciousness, which was in neuropsychiatry psychopathometrically and by this quantitatively determinable, the author was occupied by the general question: How systems can be described, which possess and exchange temperature, energy, and information? A connection of thermodynamics and information theory was found and presented in this work. It came to the redefinition of several quantities, which can be applied both in mathematical physics and in mathematical physiology. First the negentropy was defined in fact as first partial derivation of the total information on the absolute temperature. Further definitions follow: That of the shape (measured in bit.J/K), that of the action (measured in bit.J), as well that of the structure (measured in bit.J/K{sup 2}). Functional connections of information, energy, and temperature as well as of further quantities became recognizable and were written. Mathematical physics were thereby enriched, also by conservation laws. But also mathematical physiology was extended. Here diseases like the inflammatory diseases catatonia, epilepsy, tumor, vegetative dystonies, anorexy, dementia, as well as the phenomenon vitality and the phenomenon sleeping were comprehended by formulas. As consequences resulted proposals resulted for the prophylaxis and for the therapy and for the design of a live-preserving and live-elongating way of life. These proposals are in the sections, which treat the diseases, detailedly listed and derived. Furthermore a first law of psychodynamics was formulated - in analogy to the first law of thermodynamics.

  1. Sexl Physik 7 für die 7. und 8. Klasse der allgemein bildenden höheren Schulen (1. Teil)

    CERN Document Server

    Sexl, Roman U; Stadler, Helga; Jakesch, Peter; Sattlberger, Eva

    2012-01-01

    Die Schwerpunkte dieses Bandes sind die Erarbeitung der Themen Optik, Atombau und Elektrodynamik über einen historisch-philosophischen Zugang. Wie in jedem Band des Lehrgangs sind übersichtliche Zusammenfassungen, Test- und weiterführende Fragen sowie Rechenbeispiele enthalten.

  2. Armouring facility? Nuclear-weapon and reactor reseach at the Kaiser-Wilhelm Institute for Physics; Eine Waffenschmiede? Kernwaffen- und Reaktorforschung am Kaiser-Wilhelm-Institut fuer Physik

    Energy Technology Data Exchange (ETDEWEB)

    Hachtmann, R. (ed.); Walker, M.

    2005-07-01

    The Kaiser Wilhelm Institute for Physics is best known as the place where Werner Heisenberg worked on nuclear weapons for Hitler. Although this is essentially true, there is more to the story. At the start of World War II this institute was taken over by the German Army Ordnance to be the central, but not exclusive site for a research project into the economic and military applications of nuclear fission. The Army physicist Kurt Diebner was installed in the institute as its commissarial director. Heisenberg was affiliated with the institute as an advisor at first, and became the director in 1942. Heisenberg and his colleagues, including in particular Karl-Heinz Hoecker, Carl Friedrich von Weizsaecker, and Karl Wirtz, worked on nuclear reactors and isotope separation with the clear knowledge that these were two different paths to atomic bombs [Atombomben]. However, they were clearly ambivalent about what they were doing. New documents recently returned from Russian archives shed new light on this work and the scientists' motivations. (orig.)

  3. From physics to metaphysics. A sociological reconstruction of the interpretation problem of the quantum theory; Von der Physik zur Metaphysik. Eine soziologische Rekonstruktion des Deutungsproblems der Quantentheorie

    Energy Technology Data Exchange (ETDEWEB)

    Vogd, Werner

    2014-07-01

    The quantum theory represents one of the most fastidious and successful theory projects of the history of mankind. It is one, if not the universal theory of physics. The history of its interpretation and the discussion affects however by far more than only the field of theoretical physics. Such theory approach destroys ontological certainty. It calls the observer in question, and it lets us anticipate, what is to be expected, if we are employed in other fields with complex phenomena, which are infected with the observer problematics. As transclassical physics the quantum theory is so to say built on ''worlds without ground'' and disappoints by this the hope to be able to set themselves free from mind questions by physics or mathematics. Homologuously to the top forms of mystic reflexion the discussion about the interpretation of quantum physics can mediate an idea, what the mystery of the conditioned coproduction of system and environment - reflexion and world - can mean for us and possibly help us to become homelike in worlds without grounds. Hereby it becomes clear, that highly driven theory, which solves itself in its abstractions in a high degree from the live-worldly reality, stands not in contradiction to the possibility of knowledge of the world. On the contrary, at first a theory creation sufficiently elaborated and endowed with own internally conditioned consistency constraints represents the condition for the possibility of reflexion and gain of knowledge.

  4. Fascinating physics. An illustrated expedition from the universe until the world of the elementary particles; Faszinierende Physik. Ein bebildeter Streifzug vom Universum bis in die Welt der Elementarteilchen

    Energy Technology Data Exchange (ETDEWEB)

    Bahr, Benjamin [Albert-Einstein-Institut (Max-Planck Institut fuer Gravitationsphysik), Golm (Germany); Riebe, Kristin [Potsdam Univ. (Germany). Leibniz-Institut fuer Astrophysik; Resag, Joerg

    2013-07-01

    ''Fascinating physics'' is a picturesque expedition through 140 themes of classical and modern physics. On each one double-page to the reader is thereby offered a compact access in each one theme: From the aurora until the black hole, from the particle accelerator until the GPS system, from the curved space-time until the supersymmetry, from the oscillating dipole until Foucault's pendulum - a large variety of themes is taken up and carefully explained. Thereby the special strength of the book lies in the clear language and the explanations get along mostly without formulas - accompanied by breathtaking pictures, which lead the beauty of our world in front of the eyes.

  5. Tutorium quantum mechanics. By an experienced tutor for students of physics and mathematics; Tutorium Quantenmechanik. Von einem erfahrenen Tutor - fuer Physik- und Mathematikstudenten

    Energy Technology Data Exchange (ETDEWEB)

    Schwindt, Jan-Markus

    2013-07-01

    Tutorium quantum mechanics is a book, written by an experiences tutor for all, who finally want to understand from the beginning physics and mathematics of quantum mechanics. The book treats the matter of the corresponding course in the framework of theoretical physics. The main topic lies in this book on the general postulates of quantum mechanics and the clarification of the fundamental terms. What is precisely a Hilbert space? What is an Hermitian operator? A tensor product? An entangled state? To what extend wave functions are vectors? The postulates raise until today also many questions concerning their interpretation. This is discussed in a separate chapter. This book is structured in such a way that each step and each new term is explained by means of simple examples. The author attaches great importance to the clarity of the applied mathematics - something, what he and many students in other textbooks had hitherto to miss. By this main topic is also very well suited for mathematicists, who want to deal with the issue. In the examination preparation the book is especially well suited for the clarification of terms and questions of understanding. The questions of understanding and the exercise problems interspersed in the text with solutions support additionally the learning and the preparation for examination.

  6. Quantum mechanics. Textbook for students of physics, mathematics and physical chemistry. 4. ed. Quantenmechanik. Studienbuch fuer Studierende der Physik, Mathematik und Physikalischen Chemie

    Energy Technology Data Exchange (ETDEWEB)

    Grawert, G.

    1985-01-01

    The aim of the textbook now present in fourth edition is the representation of the fundamental physical concepts of the theory of quantum mechanics. It is confined to the nonrelativistic quantum mechanics; however also themes are treated which are in an extended form important just for quantum field theory up to the modern development. (orig./HSI). With 22 figs.

  7. Quantum mechanics. Textbook for students of physics, mathematics and physical chemistry. Quantenmechanik. Studienbuch fuer Studierende der Physik, Mathematik und Physikalischen Chemie

    Energy Technology Data Exchange (ETDEWEB)

    Grawert, G. (Marburg Univ. (Germany, F.R.). Fachbereich 13 - Physik)

    1989-01-01

    The aim of the textbook now present in fifth edition is the representation of the fundamental physical concepts of the theory of quantum mechanics. It is confined to the nonrelativistic quantum mechanics; however also themes are treated which are in an extended form important just for quantum field theory up to the modern development. (orig.) With 22 figs.

  8. The night of the physicists. Heisenberg, Hahn, Weizsaecker, and the German bomb; Die Nacht der Physiker. Heisenberg, Hahn, Weizsaecker und die deutsche Bombe

    Energy Technology Data Exchange (ETDEWEB)

    Schirach, Richard von

    2014-07-01

    Finally the German atomic physicists around Heisenberg, von Weizsaecker, and Hahn worked on their ''uranium machine'' in a Swabian beer-cellar - and took themselves for the world elite of nuclear research. In imprisonment they heared from the dropping of the Hiroshima bomb - a shock. Richard von Schirach shows the hindered ''fathers of the German atomic bomb'' in close-up, their eagerness, their hybris, their true importance, and their attempts to give after the war a new interpretation of their own role. A book, which raises in the sense of Duerrenmatt the question for the responsibility of science.

  9. Physics. Experimental and theoretical foundations. Pt. 3. Atomic, molecular, and quantum physics. 2. ed.; Physik. Experimentelle und theoretische Grundlagen. T. 3. Atom-, Molekuel- und Quantenphysik

    Energy Technology Data Exchange (ETDEWEB)

    Weber, Reinhart [Konstanz Univ. (Germany). Fachbereich Physik

    2012-07-01

    This textbook mediates in three volumes the matter of the first four semester of the bachelor respectively master course. The otherwise generally usual separate presentation of experimental and theoretical physics is canceled in favor of an integrated treatment. The advances are obvious: The studying is enabled to learn to understand knowledge gotten by means of experiments also immediately in a quantitative formulation. The can equally be used as textbook to an integrated course and to separated courses. Because the relevant theoretical concepts are developed without gap a special book of theoretical physics is unnecessary. Numerous exercise problems deepen the understanding and help directly in the preparation for examinations. The illustrations are mostly presented in two colours. Volume III treats atomic and molecular physics. After a semiclassical presentation the quantum-mechanical foundations are developed and in the following chapters applied to atomic systems and processes. An introduction in the foundations and application of the laser. The closure is formed by a chapter about entangled systems.

  10. X-ray anatomy - radiological imaging, radiation protection. For auxiliary medical personnel, technicians, physicists. 3. rev. and enlarged ed. Roentgenanatomie - radiologische Darstellung, Strahlenschutz. Fuer aerztliches Hilfspersonal, Techniker, Physiker

    Energy Technology Data Exchange (ETDEWEB)

    Frik, W; Goering, U

    1988-01-01

    This third edition as the result of a complete revision of the second edition reflects the current state of the art and includes topical information on a variety of advances hitherto achieved, as for instance information on novel imaging techniques in diagnostic radiology that have been included in the chapters on physical fundamentals or examination methods, as well as in all chapters discussing the anatomy and the relevant radiological imaging methods. As practice has shown that the application of the latest standards on radiation doses and units still poses problems, the authors decided to add a section explaining dose concepts, terminology and units. The two chapters dealing with contrast media and with radiological examination methods have been updated and supplemented. The anatomy chapters, written for readers who are not doctors, and the survey of the relevant diagnostic radiology still form the core of the book, but all in all this third edition now puts equal emphasis on all three aspects concerned, namely X-ray anatomy, radiological imaging, and radiation protection. (orig./MG) With 96 figs.

  11. From the depths of the universe to the microcosm. An expedition through modern physics; Von den Tiefen des Alls in den Mikrokosmos. Ein Streifzug durch die moderne Physik

    Energy Technology Data Exchange (ETDEWEB)

    Povh, Bogdan [Max-Planck-Institut fuer Kernphysik, Heidelberg (Germany)

    2017-02-01

    The following topics are dealt with: Gravitation from the beginning of astronomy until dark energy, atoms from indivisible balls until quantum-mechanical systems, atomic nuclei, the earth planet, quarks and leptons, the expanding universe. (HSI)

  12. Final theory spiral-field-model. Basic ideas for a compatible physics and a consistent nature science; Finaltheorie Spiralfeldmodell. Grundgedanken fuer eine kompatible Physik und eine konsistente Naturwissenschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hartje, U.A.J.

    2005-07-01

    This script contains theses for an universal 'Spiral-Field-Theory' that are capable to dissolve problems in parallel from different areas which are far from each other. Starting point is the stuck principle discussion about the relationships between the Classic Physics and the Quantum Physics. Aim is the clarification of questions which remained open. In 1925 Max Planck had formulated as follows: 'The research of physics can not rest, so long not has been together-welded: on the one hand the mechanics and the electrodynamics with on the other hand the lesson of the stationary one and the radiating heat to a sole unitary theory'. The Spiral-Field-Model develops a supporting structure from General Field into which they will class the secure knowledge from experiments and well-proved theories. The most important thing of this new Final Theory is the detailed generating of all nature courses of phenomena exclusively from radiation and that in the direct meaning of the word. In the final effect the two great disciplines of the physics which are drifted from each other, become bonded together to a super ordinate theoretical building of the nature sciences. (orig.)

  13. Restart of the LHC. New physics. The particle physics behind the world machine illustratively explained; Neustart des LHC. Neue Physik. Die Teilchenphysik hinter der Weltmaschine anschaulich erklaert

    Energy Technology Data Exchange (ETDEWEB)

    Knochel, Alexander

    2016-07-01

    The following topics are dealt with: The ascertainment of scientific virgin territory by means of the LHC ar CERN, the study of actual questions of cosmology and astrophysics like dark matter and dark energy by means of the LHC, the presently existing anomalies in the data with regards to new phenomena together with statistical methods for the correct estimation of such observations, the supplement of other experiments for the LHC experiments, the Higgs boson, supersymmetry, higher dimensions, the study of quantum gravity in accelerator experiments with regards to the string theory. (HSI)

  14. In the depths of the particle world. Searched for: New physics beyond the Higgs; In den Tiefen der Teilchenwelt. Gesucht: Eine neue Physik jenseits des Higgs

    Energy Technology Data Exchange (ETDEWEB)

    Beckers, Mike (comp.)

    2015-07-01

    The following topics are dealt with: Particle accelerators of the future, expected surprises from the LHC, the reality in quantum field theory, expected LHC results in string theory, the internal structure of the quarks, supersymmetry in the crisis, the search for ultralight particles, new physics with neutrinos, the still unknown properties of the neutrinos, the proton radius, the internal structure of the neutron. (HSI)

  15. Towards an explanation of the world. Milestones of physics and astrophysics; Auf dem Weg zur Erklaerung der Welt. Meilensteine der Physik und Astrophysik

    Energy Technology Data Exchange (ETDEWEB)

    Hosemann, J. Peter

    2014-07-01

    The present book wants to be helpful to explain and summarize the present status of knowledge in the main fields of research for the today unified picture of the world. Very extensively nuclear and particle physics is explained. They are the foundation of cosmology, to which the second half of the book is dedicated. To the chapter about the expansion of the universe and bout the Friedman equations follow chapters on the cosmic red shift and about distances in the universe. Discussed are the big bang and the cosmic inflation as well as dark matter, dark energy, and the accelerated expansion of the universe. Exciting are the aspects of nucleosynthesis, by which the stellar dust is generated, of which we men consist. The final chapter is dedicated to the earth, its development, and the origins of life.

  16. In the depths of the particle world. Searched for: New physics beyond the Higgs; In den Tiefen der Teilchenwelt. Gesucht: Eine neue Physik jenseits des Higgs

    Energy Technology Data Exchange (ETDEWEB)

    Koenneker, Carsten; Beckers, Mike (comps.)

    2016-07-01

    The following topics are dealt with: Future particle accelerators, possible surprising results from LHC experiments, the reality in quantum field theory, possibilities for studies of te string theory by means of the LHC, the structure of quarks, supersymmetry in crisis, the search for ultralight particles, new physics with neutrinos, the application of neutrino properties for cosmology, the paradoxon of the proton radius, the internal structure of the neutron. (HSI)

  17. Upright in the storm of time. The physicist James Franck 1882-1964; Aufrecht im Sturm der Zeit. Der Physiker James Franck 1882-1964

    Energy Technology Data Exchange (ETDEWEB)

    Lemmerich, J.

    2007-07-01

    For the 125th birth day of James Franck in the year 2007 for the first time a scientific biography is presented. Born in Hamburg Franck dedicated himself to the exploration of the atom. Together with Gustav Hertz he succeeded in exciting of bound electrons by collision, whereby the atomic model of Bohr was confirmed. For this both got the Nobel price for the year 1925. Starting from 1921 Franck founded together with Max Born and Robert Pohl the world-wide reputation of Goettingen as a center of physical research. 1933 Franck resigned because of protest against the antisemitic policy of the Nazis and imigrated to the USA. There he dedicated himself to the exploration of the foundation of the photosynthesis. To the request to contribute the the construction of the atomic bomb the Hitler opponent not denied, but wrote after the German capitulation the Franck report in May 1945, in which he described impressively the arguments against the application of the bomb and warned for a nuclear armament race. Although he was because of the great crime of the Nazi regime very critical against the Germans soon after the war he stood up - very to the indignation of his friend Einstein - for the reconcilement and visited Germany and his friends there still several times. 1964 he died at a visit in Goettingen.

  18. Contributions to naive quantum mechanics. A textbook for mathematicians and physicists; Beitraege zur naiven Quantenmechanik. Ein Leitfaden fuer Mathematiker und Physiker

    Energy Technology Data Exchange (ETDEWEB)

    Kohlmann, Martin

    2009-07-01

    The present text examplifies by means of 60 citations from current textbooks for the study of physics the necessarity of a mathematically rigorous formulation of quantum mechanics. Well known statements of many physicists about quantum mechanics at their mathematical tool kit are commented in form of a dialogue und mathematical points of view. Supplemented are the representations by a selection of theorems of higher analysis relevant for quantum theory. The book applies to mathematicians and mathematically interested physicists or students with founded mathematical knowledge.

  19. Tutorium quantum mechanics. By an experienced tutor for students of physics and mathematics. 2. ed.; Tutorium Quantenmechanik. Von einem erfahrenen Tutor - fuer Physik- und Mathematikstudenten

    Energy Technology Data Exchange (ETDEWEB)

    Schwindt, Jan-Markus

    2016-07-01

    The focus of this book lies on the general postulates of quantum mechanics (QM), their interpretation, their fundamental terms, and their mathematical formulation. The first and most comprehensive part of the book is dedicated to this thematics. In the second part an imported special case is treated: The QM of the wave functions in one, two, and three spatial dimensions under the condition, that the Hamiltonian operator consists only of the kinetic term and a timely independent potential. The most important examples hereby are the harmonic oscillator and the hydrogen atom. Also the scattering theory is discussed in this framework. The third part comprehends further themes, which belong to the canonical matter of a QM course: Combination of spin and angular momentum, QM with electromagnetism, perturbation theory, and systems with several particles. Rounded off is the whole by a short explanation of the path-integral term and by the relativistic theory of the electron (Dirac equation). Target group of this book are students of physics, who hear QM in the framework of theoretical physics. By the axiomatically deductive approach and the detailed discussion of the mathematical background it is also very well suited for mathematicians, who want to come to an understanding of QM in the subsidiary subject or in their leisure time.

  20. Energy - the problem and the transition in physics, technics, and environment; Energie - das Problem und die Wende in Physik, Technik und Umwelt

    Energy Technology Data Exchange (ETDEWEB)

    Stierstadt, Klaus

    2015-11-01

    What existed first, the energy problem or the energy transition? For the clarification of this question the author gives a survey about the actual situation of our energy demand and the means and ways to its satisfaction. The reader learns to know the function of numerous energy transformers, from the wind mill via the automobile motor until the solar cell. The advantages and disadvantages of the different transformers are explained, just so their efficiencies and cost as well as the physical natural laws, which they must obey. A perpetuum mobile doesn't exist, but indeed an almost inexhaustible energy source, the sun, which can meet many thousandfold our demand, if we use it intelligently. Who has read this book can go confidently in each discussion about the energy problem and the energy transition.

  1. Understanding modern physics by symmetry. A new approach to the fundamental theories; Durch Symmetrie die moderne Physik verstehen. Ein neuer Zugang zu den fundamentalen Theorien

    Energy Technology Data Exchange (ETDEWEB)

    Schwichtenberg, Jakob

    2017-09-01

    The following topics are dealt with: Special relativity theory, theory of Lie groups, the Lagrang formalism for field theories, quantum operators, quantum wave equations, the theory of interactions, quantum mechanics, quantum field theory, classical mechanics, electrodynamics. (HSI)

  2. ROSAT Discovers Unique, Distant Cluster of Galaxies

    Science.gov (United States)

    1995-06-01

    Brightest X-ray Cluster Acts as Strong Gravitational Lens Based on exciting new data obtained with the ROSAT X-ray satellite and a ground-based telescope at the ESO La Silla Observatory, a team of European astronomers [2] has just discovered a very distant cluster of galaxies with unique properties. It emits the strongest X-ray emission of any cluster ever observed by ROSAT and is accompanied by two extraordinarily luminous arcs that represent the gravitationally deflected images of even more distant objects. The combination of these unusual characteristics makes this cluster, now known as RXJ1347.5-1145, a most interesting object for further cosmological studies. DISCOVERY AND FOLLOW-UP OBSERVATIONS This strange cluster of galaxies was discovered during the All Sky Survey with the ROSAT X-ray satellite as a moderately intense X-ray source in the constellation of Virgo. It could not be identified with any already known object and additional ground-based observations were therefore soon after performed with the Max-Planck-Society/ESO 2.2-metre telescope at the La Silla observatory in Chile. These observations took place within a large--scale redshift survey of X-ray clusters of galaxies detected by the ROSAT All Sky Survey, a so-called ``ESO Key Programme'' led by astronomers from the Max-Planck-Institut fur Extraterrestrische Physik and the Osservatorio Astronomico di Brera. The main aim of this programme is to identify cluster X-ray sources, to determine the distance to the X-ray emitting clusters and to investigate their overall properties. These observations permitted to measure the redshift of the RXJ1347.5-1145 cluster as z = 0.45, i.e. it moves away from us with a velocity (about 106,000 km/sec) equal to about one-third of the velocity of light. This is an effect of the general expansion of the universe and it allows to determine the distance as about 5,000 million light-years (assuming a Hubble constant of 75 km/sec/Mpc). In other words, we see these

  3. Benchmarking of multiple preequilibrium routines in GNASH

    International Nuclear Information System (INIS)

    Chadwick, M.B.; Young, P.G.

    1994-08-01

    The authors compare two different models for multiple preequilibrium emission (MPE) in GNASH: the older exciton MPE model; and a new generalized MPE model which is parameter-free. They analyze the proton-induced reactions on zirconium and lead, which were the focus of a recent NEA intermediate-energy code intercomparison, using both the MPE models. They find that the new generalized MPE model better describes the measurements

  4. Market Power Europe

    DEFF Research Database (Denmark)

    Kelstrup, Jesper Dahl

    2015-01-01

    Market Power Europe (MPE) constitutes an important contribution to the literature on the global role and actorness of the EU. In order to develop MPE as a theory, this contribution provides an assessment of how Russia, the USA and China have converged towards three EU trade policies in 2013....... The analysis finds that MPE fails to account for important dynamics related to externalization in the three cases. In order to improve MPE analytically, the article suggests that MPE should include three intervening variables to account for the EU’s ability to externalize its policies and act as MPE...

  5. Continuum of quanta in the final theory. Model of spiral fields. Basic ideas for a compatible physics and a consistent nature science. 4. rev. ed.; Quantenkontinuum in der Finaltheorie. Spiralfeldmodell. Grundgedanken fuer eine Kompatible Physik und eine Konsistente Naturwissenschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hartje, Udo Albert Juergen

    2009-07-01

    The internationally favored direction of the physics sciences looks for the solution of the basic problems in higher and higher energies at impressive research constructions - mockingly mentioned as 'cognition machines' - which surpass itself with its financial efforts each the other. If in this wise shall be found: 'The elementariest bit of all elements' and 'the unity of the whole physics as well as the whole nature sciences at all', then this is a thought aberration. The prognosticated HIGGS-particles may have an exceptional quality; however, they would be very complex objects which integrate an enormous number of effect-quanta h (Planck constants) in their structure: They are with safety not simplicity. They will also not bring a better understanding about the simplicity of the last elements for us. We know since Planck, Poincare, Einstein, Bohr, Heisenberg, Schroedinger, DeBrogue and other well-known physicists that the 'atomos' can have only a diminutiveness discrete not measurable energy. The search with gigantic machines is at all especially nonsensical than it pumps still energy into the processes. However, the elementary consists of fractions from that energy what have well-known smallest particles or weakest radiation in itself puts. The work in hand follows another approach. It grasps nature on a deductive way. I start out from a most general analysis and synthesis of scientific and everyday-language concepts; and I combine that with a principle of 'general physical field' which after Einstein must exist. The dynamic space-time processes of the fields are depicted by graphic means in mathematical spatial coordinate-systems. Through it arises a consistent view over all areas of the knowledge from the most simply over simple structures until to the most complicated phenomena and things: that one are the cognition remained secretive till now obstinately. In the foreground will be originate as important the solution of the puzzle around the 'Dualism of Waves and Particles'. Structures of matter do not consist of any a priori, i.e. out the beginning existing tiniest primordial particles that secondarily swings; but they generate themselves from radiation which does not interrupt their light-fast movement in the interior of particles; and therefore it remains radiation-like. The circulation in itself creates locality; without that the radiation lost their dynamics; and without that this radiation must itself change into electrons: with their secondary turn in the orbital path. The Classic Physics and the Quantum Physics amalgamate into the 'Spiral Field Model' (Model of Spiral Fields). Classic Physics and the Quantum Physics merge in a Model of Spiral Fields into a paramount thought building with a new imagination for radiation and particles. Molecules, atoms and seedless particles have to be analyzed on the new basis. The rich fundus of proven knowledge will help. Problems of the natural sciences which do not find any immediate explanation should be taken in relation to the new thoughts; therewith will the special aspects visible. A single human is not able to it in view of the gigantic range of the accumulated knowledge. (orig.)

  6. Fascinating physics. An illustrated expedition from the universe until the world of the elementary particles. 2. ed.; Faszinierende Physik. Ein bebilderter Streifzug vom Universum bis in die Welt der Elementarteilchen

    Energy Technology Data Exchange (ETDEWEB)

    Bahr, Benjamin [Albert-Einstein-Institut (Max-Planck Institut fuer Gravitationsphysik), Golm (Germany); Riebe, Kristin [Potsdam Univ. (Germany). Leibniz-Institut fuer Astrophysik; Resag, Joerg

    2015-07-01

    The present book is an expedition across modern physics and simultaneously an illustrated voyage through the solved and unsolved enigmas of our universe. The twentieth century brought a manifold of physical discoveries. The atomic structure of matter was experimentally proved, and stepwise the structure of the atoms was decoded. Alber Einstein revolutionized with his special and general relativity theory our understanding of spca and time and unified so mechanic with electrodynamics and gravitation. Probably the most momentous upheaval learned our worldview by quantum mechanics. In the second half of the twentieth century by ever larger particle accelerators it was increasingly faced deeper penetrated into the structure of matter. Around the year 1967 it succeeded to answer the hereby occurring questions in the framework of the so-called Standard Model. Beside these fields also further partial fields of physics exist,which are not so closely connected with the inquiry of natural laws. We have four of these fields token in our book: Solid-state physics, geophysics, astronomy with astrophysics, as well as cosmology.

  7. Physics for all, who want to join in conversation. On atomic power, dirty bombs, space research, solar energy, and the global heating; Physik fuer alle, die mitreden wollen. Ueber Atomkraft, schmutzige Bomben, Weltraumforschung, Solarenergie und die globale Erwaermung

    Energy Technology Data Exchange (ETDEWEB)

    Muller, Richard A.

    2009-07-01

    Which dangers contains the global heating really? What can happen at an attack on a atomic power plant?. Which chances offer renewable energies? Questions which are put daily in the pursuing of news - but to which we have only seldomly answers ready, because basic physical knowledge is absent. But it must not even be the great world policy. Already at the decision wether solar cells shall be mounted on the roof or punted on geothermal heat physics are not unimportant. More often than we think it are natural sciences, which yield the foundations for important decisions. Richard A. Muller explains simply and illustratively, how physics determines our life. Thereby he removes prejudices and mediates quite surprising insights.

  8. Physics. Examples and problems. Mechanics, heat, electricity and magnetism, oscillations and waves, atomic and nuclear physics; Physik. Beispiele und Aufgaben. Mechanik, Waermelehre, Elektrizitaet und Magnetismus, Schwingungen und Wellen, Atom- und Kernphysik

    Energy Technology Data Exchange (ETDEWEB)

    Stroppe, Heribert; Streitenberger, Peter; Specht, Eckard; Zeitler, Juergen; Langer, Heinz

    2017-07-01

    The present book is the unification of the proved problem collections for the basic physical training of studyings of especially engineering courses at technical colleges and universities. The book contains - didactically prepared and structured in the style of a textbook as well as with increasing difficulty - a total of 960 exemplary and additional tasks from the fields mechanics, heat, electricity and magnetism, oscillations and waves, as well as atomic and nuclear physics. For the exemplary problems the whole solution path and the complete calculation process with explanation of the relevant physical laws are extensively presented, for the additional problems for the self-control only the solutions and, if necessary, intermediate calculations are given. The examples and problems with mostly practice-oriented content are selected in such a way that they largely cover the matter treated in courses and exercises and make by their didactical preparation an effective repetition and optimal examination-preparation possible.

  9. Theoretical physics 3. Classical field theory. On electrodynamics, non-Abelian gauge theories, and gravitation. 4. ed.; Theoretische Physik 3. Klassische Feldtheorie. Von Elektrodynamik, nicht-Abelschen Eichtheorien und Gravitation

    Energy Technology Data Exchange (ETDEWEB)

    Scheck, Florian [Mainz Univ. (Germany). Inst. fuer Physik

    2017-09-01

    The following topics are dealt with: Maxwell's equations together with their symmetry and covariance, the Maxwell theory as classical field theory, simple applications of Maxwell's theory, local gauge theories, classical field theory of gravitation. (HSI)

  10. Sharpest Ever VLT Images at NAOS-CONICA "First Light"

    Science.gov (United States)

    2001-12-01

    demonstration of the value of international collaboration. ESO and its partner institutes and companies in France and Germany have worked a long time towards this goal - with the first, extremely promising results, we shall soon be able to offer a new and fully tuned instrument to our wide research community." The NAOS adaptive optics corrector was built, under an ESO contract, by Office National d'Etudes et de Recherches Aérospatiales (ONERA) , Laboratoire d'Astrophysique de Grenoble (LAOG) and the DESPA and DASGAL laboratories of the Observatoire de Paris in France, in collaboration with ESO. The CONICA infra-red camera was built, under an ESO contract, by the Max-Planck-Institut für Astronomie (MPIA) (Heidelberg) and the Max-Planck Institut für Extraterrestrische Physik (MPE) (Garching) in Germany, in collaboration with ESO. The present event happens less than four weeks after "First Fringes" were achieved for the VLT Interferometer (VLTI) with two of the 8.2-m Unit Telescopes. No wonder that a spirit of great enthusiasm reigns at Paranal! Information for the media: ESO is producing a Video News Release ( ESO Video News Reel No. 13 ) with sequences from the NAOS-CONICA "First Light" event at Paranal, a computer animation illustrating the principle of adaptive optics in NAOS-CONICA, as well as the first astronomical images obtained. In addition to the usual distribution, this VNR will also be transmitted via satellite Friday 7 December 2001 from 09:00 to 09:15 CET (10:00 to 10:15 UT) on "Europe by Satellite" . These video images may be used free of charge by broadcasters. Satellite details, the script and the shotlist will be on-line from 6 December on the ESA TV Service Website http://television.esa.int. Also a pre-view Real Video Stream of the video news release will be available as of that date from this URL. Video Clip 07/01 : Various video scenes related to the NAOS-CONICA "First Light" Event ( ESO Video News Reel No. 13 ). PR Photo 33a/01 : NAOS-CONICA "First light

  11. Youngest Brown Dwarf Yet in a Multiple Stellar System

    Science.gov (United States)

    2000-07-01

    that direct detection and subsequent, effective spectroscopic verification of extra-solar planets is now quite feasible with a ground-based facility like the VLT. It is thus not a very daring prediction that the ongoing searches may soon lead to the first direct images of an extra-solar planet. These are indeed exciting times! More information The work described in this Press Release is discussed by the team in a research article that has been accepted for publication in the European journal Astronomy & Astrophysics. Another paper ( "Direct imaging search for planetary companions next to young nearby stars" ) is also available with more details about the current searches, including the spectrum of the background star at TWA-7. The Principal Investigator for this project may be contacted at: Ralph Neuhaeuser Max-Planck-Institut für Extraterrestrische Physik D-85748 Garching Germany Phone +49-89-32993398 email: rne@mpe.mpg.de Notes [1]: The team consists of Ralph Neuhaeuser (Principal Investigator) and Nuria Huelamo (both Max-Planck-Institut für Extraterrestrische Physik, Garching, Germany), Eike Guenther (Landessternwarte Tautenburg, Germany), Monika Petr (Max-Planck-Institut für Radioastronomie, Bonn, Germany), Wolfgang Brandner (Institute for Astronomy, Honolulu, Hawaii, USA) and João Alves (ESO, Garching, Germany). [2]: The hitherto sharpest image (0.25 arcsec) was obtained in March 1999, cf. ESO PR 06/99. It was obtained during a period of exceptionally good "seeing" (low level of atmospheric turbulence). The installation of adaptive optics at the VLT, foreseen in 2001, will provide a means to overcome the image smearing effect of air turbulence and hence, consistently obtain stellar images of a few hundredths of an arcsecond diameter, near the theoretical limit for an 8.2-m telescope (the telescope diffraction limit ). [3]: 1 solar mass = 2 x 10 30 kg. 1 Jupiter mass = 2 x 10 27 kg ~ 0.001 solar mass. Thus, the "BD-limit" of 0.08 solar masses corresponds to

  12. Motivation toward Physical Exercise and Subjective Wellbeing: The Mediating Role of Trait Self-Control

    Directory of Open Access Journals (Sweden)

    Walid Briki

    2016-10-01

    Full Text Available Motivation toward physical exercise (MPE and trait self-control (TSC were identified as key predictors of subjective wellbeing (SWB. However, there has not been any research designed to examine the mediating role of TSC in the relationship between MPE and SWB. The present study utilizes self-determination theory, control-process theory of self-regulation, and theory of multiple pathways of TSC in order to examine whether TSC mediates the relationships of autonomous MPE (A-MPE, controlled MPE (C-MPE, and impersonal MPE (NO-MPE with SWB using structural equation modeling (XLSTAT PLS. Three hundred seventeen adult American individuals (Mage = 32.97, SDage = 11.30, who reported to be regular exercisers, voluntarily answered questionnaires assessing MPE, TSC, and SWB. Correlational analyses revealed positive relationships between A-MPE, TSC, and SWB, and negative relationships of C-MPE and NO-MPE with TSC and SWB. Mediation analyses revealed that TSC mediated the relationships of A-MPE (partial mediation and C-MPE (full mediation with SWB, but did not mediate the relationship between NO-MPE and SWB. The estimates of the quality of the hypothesized model were acceptable (outer model GoF = .935; absolute GoF = .330; relative GoF = .942; inner model GoF = 1.008; R2 = 36.947%. Finally, this study supports the view that MPE can influence SWB through TSC, and incites to pursue the examination of the relationships between self-determined motivation, self-regulation mechanisms, and health-related outcomes.

  13. EDITORIAL: Invited review and topical lectures from the 13th International Congress on Plasma Physics

    Science.gov (United States)

    Zagorodny, A.; Kocherga, O.

    2007-05-01

    The 13th International Congress on Plasma Physics (ICPP 2006) was organized, on behalf of the International Advisory Committee of the ICPP series, by the National Academy of Sciences of Ukraine and the Bogolyubov Institute for Theoretical Physics (BITP) and held in Kiev, Ukraine, 22 26 May 2006. The Congress Program included the topics: fundamental problems of plasma physics; fusion plasmas; plasmas in astrophysics and space physics; plasmas in applications and technologies; complex plasmas. A total of 305 delegates from 30 countries took part in the Congress. The program included 9 invited review lectures, 32 invited topical and 313 contributed papers (60 of which were selected for oral presentation). The Congress Program was the responsibility of the International Program Committee: Anatoly Zagorodny (Chairman) Bogolyubov Institute for Theoretical Physics, Ukraine Olha Kocherga (Scientific Secretary) Bogolyubov Institute for Theoretical Physics, Ukraine Boris Breizman The University of Texas at Austin, USA Iver Cairns School of Physics, University of Sydney, Australia Tatiana Davydova Institute for Nuclear Research, Ukraine Tony Donne FOM-Institute for Plasma Physics, Rijnhuizen, The Netherlands Nikolai S Erokhin Space Research Institute of RAS, Russia Xavier Garbet CEA, France Valery Godyak OSRAM SYLVANIA, USA Katsumi Ida National Institute for Fusion Science, Japan Alexander Kingsep Russian Research Centre `Kurchatov Institute', Russia E P Kruglyakov Budker Institute of Nuclear Physics, Russia Gregor Morfill Max-Planck-Institut für extraterrestrische Physik, Germany Osamu Motojima National Institute for Fusion Science, Japan Jef Ongena ERM-KMS, Brussels and EFDA-JET, UK Konstantyn Shamrai Institute for Nuclear Research, Ukraine Raghvendra Singh Institute for Plasma Research, India Konstantyn Stepanov Kharkiv Institute of Physics and Technology, Ukraine Masayoshi Tanaka National Institute for Fusion Science, Japan Nodar Tsintsadze Physics Institute, Georgia The

  14. Boltzmann und das Ende des mechanistischen Weltbildes

    CERN Document Server

    Renn, Jürgen

    2007-01-01

    Der Wissenschaftshistoriker und Physiker Jürgen Renn untersucht die Rolle des österreichischen Physikers und Philosophen Ludwig Boltzmann (18441906) bei der Entwicklung der modernen Physik. Boltzmann war einer der letzen Vertreter des mechanistischen Weltbildes und stand somit am Ende eines Zeitalters. Renn porträtiert den Wissenschaftler aber als einen Pionier der modernen Physik, dessen Beschäftigung mit den inneren Spannungen der klassischen Physik ihn visionär zukünftige Fragestellungen aufgreifen ließ. So befasste sich Boltzmann etwa mit den Grenzproblemen zwischen Mechanik und Thermodynamik, die ihn zur Entwicklung immer raffinierterer Instrumente der statistischen Physik antrieb, die schließlich zu Schlüsselinstrumenten der modernen Physik wurden. Boltzmanns Werk steht somit am Übergang vom mechanistischen Weltbild zur Relativitäts- und Quantentheorie. Der Aussage des viel bekannteren Physikers Albert Einstein, dass Fantasie wichtiger sei als Wissen, hält Jürgen Renn im Hinblick auf Leben ...

  15. The malignant pleural effusion as a model to investigate intratumoral heterogeneity in lung cancer.

    Directory of Open Access Journals (Sweden)

    Saroj K Basak

    Full Text Available Malignant Pleural Effusions (MPE may be useful as a model to study hierarchical progression of cancer and/or intratumoral heterogeneity. To strengthen the rationale for developing the MPE-model for these purposes, we set out to find evidence for the presence of cancer stem cells (CSC in MPE and demonstrate an ability to sustain intratumoral heterogeneity in MPE-primary cultures. Our studies show that candidate lung CSC-expression signatures (PTEN, OCT4, hTERT, Bmi1, EZH2 and SUZ12 are evident in cell pellets isolated from MPE, and MPE-cytopathology also labels candidate-CSC (CD44, cMET, MDR-1, ALDH subpopulations. Moreover, in primary cultures that use MPE as the source of both tumor cells and the tumor microenvironment (TME, candidate CSC are maintained over time. This allows us to live-sort candidate CSC-fractions from the MPE-tumor mix on the basis of surface markers (CD44, c-MET, uPAR, MDR-1 or differences in xenobiotic metabolism (ALDH. Thus, MPE-primary cultures provide an avenue to extract candidate CSC populations from individual (isogenic MPE-tumors. This will allow us to test whether these cells can be discriminated in functional bioassays. Tumor heterogeneity in MPE-primary cultures is evidenced by variable immunolabeling, differences in colony-morphology, and differences in proliferation rates of cell subpopulations. Collectively, these data justify the ongoing development of the MPE-model for the investigation of intratumoral heterogeneity, tumor-TME interactions, and phenotypic validation of candidate lung CSC, in addition to providing direction for the pre-clinical development of rational therapeutics.

  16. Mucuna pruriens Linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of Naja sputatrix (Javan spitting cobra) venom in rats.

    Science.gov (United States)

    Fung, Shin Yee; Tan, Nget Hong; Sim, Si Mui; Marinello, Enrico; Guerranti, Roberto; Aguiyi, John Chinyere

    2011-04-01

    Mucuna pruriens has been used by native Nigerians as a prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the pharmacological actions of N. sputatrix (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of N. sputatrix venom. These may be explained at least in part by the neutralisation of the cobra venom toxins by anti-MPE antibodies elicited by the MPE pretreatment.

  17. Intrapleural cisplatin for management of malignant pleural effusion in a patient with plasma cell leucaemia.

    Science.gov (United States)

    Agarwal, Abhishek; Klair, Jagpal; Patolia, Setu; Meena, Nikhil K

    2015-06-29

    Plasma cell leucaemia (PCL) is a rare aggressive form of multiple myeloma. It occasionally involves the pleura, causing malignant pleural effusion (MPE). MPE presents a management dilemma for physicians, given the different treatment options available with varying efficacy and side effects. We report a case of a 64-year-old man with MPE due to PCL, successfully managed with intrapleural cisplatin and a tunnelled pleural catheter. We believe this to be the first report of management of PCL-associated MPE with intrapleural cisplatin. 2015 BMJ Publishing Group Ltd.

  18. Universe of quantum whirls in the final theory spiral field model. Basic ideas for a compatible physics and a consistent nature science. 3. rev. ed.; Universum der Quantenwirbel in der Finaltheorie Spiralfeldmodell. Grundgedanken fuer eine kompatible Physik und eine konsistente Naturwissenschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hartje, Udo A.J.

    2008-07-01

    Internationally stressed physics is looking for the solution of the basic problems of physics at higher and higher energies in impressive plants which outbid themselves in their expenditure for technology reciprocally. If with this manner shall be to seek the ''atomos'' and the ''unit of the physics'' then this is an error way. Sought-after Higgs particles are certainly not a simply thing; but a most complex object which would contain an enormous number of effect quanta in its structure. Since Planck, Poincare, Einstein, Bohr, Heisenberg, Schroedinger, De Broglie and others well-known physicists we know that this ''atomos'' have only a tiny energy quantity which single is not measurable. The search with gigantic machines is at all besides more nonsensical than such processes there will pump even energy into it. The elementary contains only fractions from the energy what is in known smallest particles or weakest beams too. This work follows another approach to grasp the nature in a Final Theory (Grand Unification) on a deductive way. It starts from a most general analysis and synthesis of scientific and everyday-language concepts. This shored up it on the principle of general physical field. The dynamic processes of the field are vivid illustrated by graphic means in systems of coordinates with space-time. Through it arises a everywhere consistent view for most simple existences and simple structures up to most complicate existences for all fields of physics and philosophy. That remained shut off till now obstinately for the cognition. A important result is the solution of the puzzle of ''Dualism of Wave and Particle''. Matter-structures consist not from 'a priori' existing 'little verdicts' which secondary swing. But they consist from beams; which remain in the inside of the particles radiation-like: and they rotate there in themselves. This creates locality without changing the radiation itself into 'electrons' which rotate on paths. The Classical Physics and the Quantum Physics merge with a new radiation and particle model in the ''Spiral Field Model'' to an united primary edifice of ideas. Atoms and other particles must be analyzed on a new basis in which the rich fund of recognized knowledge will help. Some puzzles come to solution alone by the new position. Other unsolved problems of the nature science must be brought in connection with the strange thoughts; that the individual aspects will visibly. A single person is not able to it in the face of the gigantic mountain at accumulated knowledge. (orig.)

  19. Universe of quantum whirls in the final theory spiral field model. Basic ideas for a compatible physics and a consistent nature science. 2. rev. ed.; Universum der Quantenwirbel in der Finaltheorie Spiralfeldmodell. Grundgedanken fuer eine kompatible Physik und eine konsistente Naturwissenschaft

    Energy Technology Data Exchange (ETDEWEB)

    Hartje, Udo A.J.

    2007-07-01

    Internationally stressed physics is looking for the solution of the basic problems of physics at higher and higher energies in impressive plants which outbid themselves in their expenditure for technology reciprocally. If with this manner shall be to seek the ''atomos'' and the ''unit of the physics'' then this is an error way. Sought-after Higgs particles are certainly not a simply thing; but a most complex object which would contain an enormous number of effect quanta in its structure. Since Planck, Poincare, Einstein, Bohr, Heisenberg, Schroedinger, De Broglie and others well-known physicists we know that this ''atomos'' have only a tiny energy quantity which single is not measurable. The search with gigantic machines is at all besides more nonsensical than such processes there will pump even energy into it. The elementary contains only fractions from the energy what is in known smallest particles or weakest beams too. This work follows another approach to grasp the nature in a Final Theory (Grand Unification) on a deductive way. It starts from a most general analysis and synthesis of scientific and everyday-language concepts. This shored up it on the principle of general physical field. The dynamic processes of the field are vivid illustrated by graphic means in systems of coordinates with space-time. Through it arises a everywhere consistent view for most simple existences and simple structures up to most complicate existences for all fields of physics and philosophy. That remained shut off till now obstinately for the cognition. A important result is the solution of the puzzle of ''Dualism of Wave and Particle''. Matter-structures consist not from 'a priori' existing 'little verdicts' which secondary swing. But they consist from beams; which remain in the inside of the particles radiation-like: and they rotate there in themselves. This creates locality without changing the radiation itself into 'electrons' which rotate on paths. The Classical Physics and the Quantum Physics merge with a new radiation and particle model in the ''Spiral Field Model'' to an united primary edifice of ideas. Atoms and other particles must be analyzed on a new basis in which the rich fund of recognized knowledge will help. Some puzzles come to solution alone by the new position. Other unsolved problems of the nature science must be brought in connection with the strange thoughts; that the individual aspects will visibly. A single person is not able to it in the face of the gigantic mountain at accumulated knowledge. (orig.)

  20. X-rays, radiometers and skin unit dose. The development of measuring methods and measuring units for X radiation in medical physics from the beginning until the international standardization; X-Strahlen, Radiometer und Hauteinheitsdosis. Die Entwicklung der Messverfahren und Masseinheiten fuer Roentgenstrahlung in der medizinischen Physik von den Anfaengen bis zur internationalen Standardisierung

    Energy Technology Data Exchange (ETDEWEB)

    Glessmer-Junike, Simone

    2015-01-22

    X-rays, a special form of ionizing radiation, have been utilized in medicine and technology ever since their discovery at the end of 1895. However, the usage of X-rays made the development of measuring techniques necessary. Newly-developed measuring devices were at first called radiometers', but later the term dosimeter' has gained universal acceptance. The development of numerous dosimeters used in radiotherapy was accompanied by new units of measurement, each corresponding to its individual newly constructed dosimeter or method of measurement. While at first conversions between old and new units were performed, it later became clear that both within Germany and Europe units with similar names were used with different meanings, which was both incompatible and confusing. The first serious attempts of a standardization of units in Germany were made after the First World War, when the when the ionizing properties of X-rays was focused on for both measurements and unit definitions. Efforts towards an international standardization of units became successful in the mid-1920s when the Roentgen was defined as the universal unit. From the development described above, four stages of the evolution of radiation measurement and units in radiotherapy could be identified by means of comprehensive systematic research in printed publications. The first stage was the period of diagnostic application of X-rays, when tools for the determination of X-ray quality were designed. This stage progressed into that of therapeutic administration of X-rays shortly after, when instruments and units for the measurement of X-ray quantities (dose') were implemented. Due to the variety and diversity of measurement apparatus and units a third stage emerged, closely interconnected with the second. During the third stage, a nation-wide standardization was attempted in Germany. With the conclusion of this stage - the resolution of a unit for dose measurement in Germany - the stage of international standardization began. This fourth stage continues arguably to the present day, since by now not only units, but also standards for both measurement of these units and quality assurance, are developed in international cooperation. This study presents how present-day knowledge of fundamental physical laws, of potential measurement errors and of shortcomings of methods contribute to a better understanding of the historical process of the development portrayed here. When applying scientific discoveries to medicine and technology, this historical knowledge is an essential prerequisite for successful communication in a globalized world, which depends on international standards for manufacturing and application of measurement devices.

  1. Observing a Burst with Sunglasses

    Science.gov (United States)

    2003-11-01

    Unique Five-Week VLT Study of the Polarisation of a Gamma-Ray Burst Afterglow "Gamma-ray bursts (GRBs)" are certainly amongst the most dramatic events known in astrophysics. These short flashes of energetic gamma-rays, first detected in the late 1960's by military satellites, last from less than one second to several minutes. GRBs have been found to be situated at extremely large ("cosmological") distances. The energy released in a few seconds during such an event is larger than that of the Sun during its entire lifetime of more than 10,000 million years. The GRBs are indeed the most powerful events since the Big Bang known in the Universe, cf. ESO PR 08/99 and ESO PR 20/00. During the past years circumstantial evidence has mounted that GRBs signal the collapse of extremely massive stars, the so-called hypernovae. This was finally demonstrated some months ago when astronomers, using the FORS instrument on ESO's Very Large Telescope (VLT), documented in unprecedented detail the changes in the spectrum of the light source ("the optical afterglow") of the gamma-ray burst GRB 030329 (cf. ESO PR 16/03). A conclusive and direct link between cosmological gamma-ray bursts and explosions of very massive stars was provided on this occasion. Gamma-Ray Burst GRB 030329 was discovered on March 29, 2003 by NASA's High Energy Transient Explorer spacecraft. Follow-up observations with the UVES spectrograph at the 8.2-m VLT KUEYEN telescope at the Paranal Observatory (Chile) showed the burst to have a redshift of 0.1685 [1]. This corresponds to a distance of about 2,650 million light-years, making GRB 030329 the second-nearest long-duration GRB ever detected. The proximity of GRB 030329 resulted in very bright afterglow emission, permitting the most extensive follow-up observations of any afterglow to date. A team of astronomers [2] led by Jochen Greiner of the Max-Planck-Institut für extraterrestrische Physik (Germany) decided to make use of this unique opportunity to study the

  2. Recursive Lexicographical Search

    DEFF Research Database (Denmark)

    Iskhakov, Fedor; Rust, John; Schjerning, Bertel

    2016-01-01

    of Bertrand price competition with cost reducing investments which we show is a DDG. We provide an exact non- iterative algorithm that finds all MPE of every stage game, and prove there can be only 1, 3 or 5 of them. Using the stage games as building blocks, RLS rapidly finds and enumerates all MPE...

  3. Multiprofessional education to stimulate collaboration: a circular argument and its consequences.

    Science.gov (United States)

    Roodbol, Petrie F

    2010-01-01

    The current developments in healthcare are unprecedented. The organization of health care is complex. Collaboration is essential to meet all the healthcare needs of patients and to achieve coordinated and unambiguous information. Multiprofessional education (MPE) or multidisciplinary training (MDT) seems a logical step to stimulate teamwork. However, collaboration and MPE are wrestling with the same problems: social identity and acceptance.

  4. Multiprofessional education to stimulate collaboration: a circular argument and its consequences [

    Directory of Open Access Journals (Sweden)

    Roodbol, Petrie F.

    2010-04-01

    Full Text Available [english] The current developments in healthcare are unprecedented. The organization of health care is complex. Collaboration is essential to meet all the healthcare needs of patients and to achieve coordinated and unambiguous information. Multiprofessional education (MPE or multidisciplinary training (MDT seems a logical step to stimulate teamwork. However, collaboration and MPE are wrestling with the same problems: social identity and acceptance.

  5. Exorcising the ghost of the past: The abandonment of obsession ...

    African Journals Online (AJOL)

    This article examines how Phaswane Mpe's post-apartheid novel, Welcome to Our Hillbrow (2000), responds to Njabulo Ndebele's idea of “rediscovering the ordinary”. This is probed through analyses of themes, characterization and style. It will be argued that, through Welcome to Our Hillbrow, Mpe makes a call for ...

  6. Transient changes in milk production efficiency and bacterial community composition resulting from near-total exchange of ruminal contents between high- and low-efficiency Holstein cows

    Science.gov (United States)

    The objectives of this study were to determine if milk production efficiency (MPE) is altered by near-total exchange of ruminal contents between high- (HE) and low-MPE (LE) cows and to characterize ruminal bacterial community composition (BCC) prior to exchange and over time post-exchange. Three pai...

  7. CNN - en succes i krise

    DEFF Research Database (Denmark)

    Böss, Michael

    1994-01-01

    Om CNN og den krise, netværket hele tiden må bekæmpe og dække. Udgivelsesdato: 26. september......Om CNN og den krise, netværket hele tiden må bekæmpe og dække. Udgivelsesdato: 26. september...

  8. Nutritional and sensory quality evaluation of sponge cake prepared by incorporation of high dietary fiber containing mango (Mangifera indica var. Chokanan) pulp and peel flours.

    Science.gov (United States)

    Aziah, A A Noor; Min, W Lee; Bhat, Rajeev

    2011-09-01

    Sponge cake prepared by partial substitution of wheat flour with mango pulp and mango peel flours (MPuF and MPeF, respectively) at different concentrations (control, 5%, 10%, 20% or 30%) were investigated for the physico-chemical, nutritional and organoleptic characteristics. Results showed sponge cake incorporated with MPuF and MPeF to have high dietary fiber with low fat, calorie, hydrolysis and predicted glycemic index compared with the control. Increasing the levels of MPuF and MPeF in sponge cake had significant impact on the volume, firmness and color. Sensory evaluation showed sponge cake formulated with 10% MPuF and 10% MPeF to be the most acceptable. MPeF and MPuF have high potential as fiber-rich ingredients and can be utilized in the preparation of cake and other bakery products to improve the nutritional qualities.

  9. Mission to planet earth: A call to repeal the Landsat Act

    International Nuclear Information System (INIS)

    Gabrynowicz, J.I.; Wood, C.A.

    1991-01-01

    Mission to Planet Earth (MPE) is being planned to provide scientists with data and information about global climate change so that policymakers can make informed decisions in directing the nation's response to the change. A crucial component of MPE is the Landsat system and the continuous, multidecade database it has produced. Yet because of an ill-conceived and poorly-executed commercialization policy, MPE researchers are being deprived of these vital national assets, profoundly hampering their ability to carry out the work of MPE. Effects of the US commercialization policy have reached abroad. The French, Japanese, and Canadians, following the US lead, have also commercialized their existing and future land remote sensing systems - further inhibiting the free flow of data among these complementary systems and preventing a truly international, scientific effort in MPE. Meeting the challenges of global climate change requires reconsidering the proper role of the Landsat system and identifying appropriate and inappropriate commercial remote sensing activities

  10. The Exploration of Peptide Biomarkers in Malignant Pleural Effusion of Lung Cancer Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry

    Directory of Open Access Journals (Sweden)

    Jing Xu

    2017-01-01

    Full Text Available Background. Diagnoses of malignant pleural effusion (MPE are a crucial problem in clinics. In our study, we compared the peptide profiles of MPE and tuberculosis pleural effusion (TPE to investigate the value of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS in diagnosis of MPE. Material and Methods. The 46 MPE and 32 TPE were randomly assigned to training set and validation set. Peptides were isolated by weak cation exchange magnetic beads and peaks in the m/z range of 800–10000 Da were analyzed. Comparing the peptide profile between 30 MPE and 22 TPE samples in training set by ClinProTools software, we screened the specific biomarkers and established a MALDI-TOF-MS classification of MPE. Finally, the other 16 MPE and 10 TPE were included to verify the model. We additionally determined carcinoembryonic antigen (CEA in MPE and TPE samples using electrochemiluminescent immunoassay method. Results. Five peptide peaks (917.37 Da, 4469.39 Da, 1466.5 Da, 4585.21 Da, and 3216.87 Da were selected to separate MPE and TPE by MALDI-TOF-MS. The sensitivity, specificity, and accuracy of the classification were 93.75%, 100%, and 96.15%, respectively, after blinded test. The sensitivity of CEA was significantly lower than MALDI-TOF-MS classification (P=0.035. Conclusions. The results indicate MALDI-TOF-MS is a potential method for diagnosing MPE.

  11. Beneficial impact of CCL2 and CCL12 neutralization on experimental malignant pleural effusion.

    Directory of Open Access Journals (Sweden)

    Antonia Marazioti

    Full Text Available Using genetic interventions, we previously determined that C-C motif chemokine ligand 2 (CCL2 promotes malignant pleural effusion (MPE formation in mice. Here we conducted preclinical studies aimed at assessing the specific therapeutic potential of antibody-mediated CCL2 blockade against MPE. For this, murine MPEs or skin tumors were generated in C57BL/6 mice by intrapleural or subcutaneous delivery of lung (LLC or colon (MC38 adenocarcinoma cells. Human lung adenocarcinoma cells (A549 were used to induce MPEs in severe combined immunodeficient mice. Intraperitoneal antibodies neutralizing mouse CCL2 and/or CCL12, a murine CCL2 ortholog, were administered at 10 or 50 mg/kg every three days. We found that high doses of CCL2/12 neutralizing antibody treatment (50 mg/kg were required to limit MPE formation by LLC cells. CCL2 and CCL12 blockade were equally potent inhibitors of MPE development by LLC cells. Combined CCL2 and CCL12 neutralization was also effective against MC38-induced MPE and prolonged the survival of mice in both syngeneic models. Mouse-specific CCL2-blockade limited A549-caused xenogeneic MPE, indicating that host-derived CCL2 also contributes to MPE precipitation in mice. The impact of CCL2/12 antagonism was associated with inhibition of immune and vascular MPE-related phenomena, such as inflammation, new blood vessel assembly and plasma extravasation into the pleural space. We conclude that CCL2 and CCL12 blockade are effective against experimental MPE induced by murine and human adenocarcinoma in mice. These results suggest that CCL2-targeted therapies may hold promise for future use against human MPE.

  12. Molecular pathological epidemiology: new developing frontiers of big data science to study etiologies and pathogenesis.

    Science.gov (United States)

    Hamada, Tsuyoshi; Keum, NaNa; Nishihara, Reiko; Ogino, Shuji

    2017-03-01

    Molecular pathological epidemiology (MPE) is an integrative field that utilizes molecular pathology to incorporate interpersonal heterogeneity of a disease process into epidemiology. In each individual, the development and progression of a disease are determined by a unique combination of exogenous and endogenous factors, resulting in different molecular and pathological subtypes of the disease. Based on "the unique disease principle," the primary aim of MPE is to uncover an interactive relationship between a specific environmental exposure and disease subtypes in determining disease incidence and mortality. This MPE approach can provide etiologic and pathogenic insights, potentially contributing to precision medicine for personalized prevention and treatment. Although breast, prostate, lung, and colorectal cancers have been among the most commonly studied diseases, the MPE approach can be used to study any disease. In addition to molecular features, host immune status and microbiome profile likely affect a disease process, and thus serve as informative biomarkers. As such, further integration of several disciplines into MPE has been achieved (e.g., pharmaco-MPE, immuno-MPE, and microbial MPE), to provide novel insights into underlying etiologic mechanisms. With the advent of high-throughput sequencing technologies, available genomic and epigenomic data have expanded dramatically. The MPE approach can also provide a specific risk estimate for each disease subgroup, thereby enhancing the impact of genome-wide association studies on public health. In this article, we present recent progress of MPE, and discuss the importance of accounting for the disease heterogeneity in the era of big-data health science and precision medicine.

  13. Multiple Payload Ejector for Education, Science and Technology Experiments

    Science.gov (United States)

    Lechworth, Gary

    2005-01-01

    The education research community no longer has a means of being manifested on Space Shuttle flights, and small orbital payload carriers must be flown as secondary payloads on ELV flights, as their launch schedule, secondary payload volume and mass permits. This has resulted in a backlog of small payloads, schedule and cost problems, and an inability for the small payloads community to achieve routine, low-cost access to orbit. This paper will discuss Goddard's Wallops Flight Facility funded effort to leverage its core competencies in small payloads, sounding rockets, balloons and range services to develop a low cost, multiple payload ejector (MPE) carrier for orbital experiments. The goal of the MPE is to provide a low-cost carrier intended primarily for educational flight research experiments. MPE can also be used by academia and industry for science, technology development and Exploration experiments. The MPE carrier will take advantage of the DARPAI NASA partnership to perform flight testing of DARPA s Falcon small, demonstration launch vehicle. The Falcon is similar to MPE fiom the standpoint of focusing on a low-cost, responsive system. Therefore, MPE and Falcon complement each other for the desired long-term goal of providing the small payloads community with a low-cost ride to orbit. The readiness dates of Falcon and MPE are complementary, also. MPE is being developed and readied for flight within 18 months by a small design team. Currently, MPE is preparing for Critical Design Review in fall 2005, payloads are being manifested on the first mission, and the carrier will be ready for flight on the first Falcon demonstration flight in summer, 2006. The MPE and attached experiments can weigh up to 900 lb. to be compatible with Falcon demonstration vehicle lift capabilities fiom Wallops, and will be delivered to the Falcon demonstration orbit - 100 nautical mile circular altitude.

  14. Palliative Treatment of Malignant Pleural Effusion

    Directory of Open Access Journals (Sweden)

    Chenyang Liu

    2015-01-01

    Full Text Available Malignant pleural effusion (MPE is a common clinical problem caused by cancers. Pleural effusion can be the first sign of cancer in more than 25% of patients. Lung cancer and breast cancer are the most common cancers that metastasize to the pleura in men and women, respectively. Other cancers, including, but not limited to, lymphomas, ovarian cancer, stomach cancer, and several unknown primary cancers can also lead to MPE. Dyspnea and chest pain are the most common symptoms of MPE along with other symptoms such as a cough, weight loss, anorexia, fatigue, and weakness. Aggravation of these symptoms is closely related to the rate of accumulation of pleural effusion. Treatment options to MPE are determined by the type and extent of the underlying malignancy. The major goals of the treatment are to relieve symptoms, restore functions, improve the quality of life, and minimize the duration of hospital stay and costs. Although some patients can be treated with systemic therapies, most of these treatments are temporary, and MPE would recur soon. Hence, further palliative treatments to effectively control pleural effusions and relieve symptoms are necessary. This review addresses the pathophysiology of MPE and the treatment options for patients with MPE.

  15. Expression Profile of Three Splicing Factors in Pleural Cells Based on the Underlying Etiology and Its Clinical Values in Patients with Pleural Effusion

    Directory of Open Access Journals (Sweden)

    A-Lum Han

    2018-02-01

    Full Text Available Splicing factors (SFs are involved in oncogenesis or immune modulation, the common underlying processes giving rise to pleural effusion (PE. The expression profiles of three SFs (HNRNPA1, SRSF1, and SRSF3 and their clinical values have never been assessed in PE. The three SFs (in pellets of PE and conventional tumor markers were analyzed using PE samples in patients with PE (N = 336. The sum of higher–molecular weight (Mw forms of HNRNPA1 (Sum-HMws-HNRNPA1 and SRSF1 (Sum-HMws-SRSF1 and SRSF3 levels were upregulated in malignant PE (MPE compared to benign PE (BPE; they were highest in cytology-positive MPE, followed by tuberculous PE and parapneumonic PE. Meanwhile, the lowest-Mw HNRNPA1 (LMw-HNRNPA1 and SRSF1 (LMw-SRSF1 levels were not upregulated in MPE. Sum-HMws-HNRNPA1, Sum-HMws-SRSF1, and SRSF3, but neither LMw-HNRNPA1 nor LMw-SRSF1, showed positive correlations with cancer cell percentages in MPE. The detection accuracy for MPE was high in the order of carcinoembryonic antigen (CEA, 85%, Sum-HMws-HNRNPA1 (76%, Sum-HMws-SRSF1 (68%, SRSF3, cytokeratin-19 fragments (CYFRA 21-1, LMw-HNRNPA1, and LMw-SRSF1. Sum-HMws-HNRNPA1 detected more than half of the MPE cases that were undetected by cytology and CEA. Sum-HMws-HNRNPA1, but not other SFs or conventional tumor markers, showed an association with longer overall survival among patients with MPE receiving chemotherapy. Our results demonstrated different levels of the three SFs with their Mw-specific profiles depending on the etiology of PE. We suggest that Sum-HMws-HNRNPA1 is a supplementary diagnostic marker for MPE and a favorable prognostic indicator for patients with MPE receiving chemotherapy.

  16. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression.

    Science.gov (United States)

    Rana, Digvijay G; Galani, Varsha J

    2014-01-01

    The effects of antidepressant treatments have traditionally been discussed primarily in terms of effects on noradrenergic and serotonergic systems. Multiple lines of investigation have also explored the role of dopaminergic systems in mental depression. Seed of Mucuna pruriens Linn. (DC) (Leguminoseae) is well-known with dopaminergic action and has several therapeutic applications in folk medicine in curing or managing a wide range of diseases including Parkinsonism. To elucidate the anti-depressent profile and possible dopaminergic modulating action of M. pruriens seeds in various experimental models of depression. In the present study, antidepressant effect of the hydroalcoholic extract of the M. pruriens seeds (MPE) (100 and 200 mg/kg, p.o.) was investigated in the Forced Swimming Test (FST), Tail Suspension Test (TST), and Chronic Unpredictable Mild Stress (CUMS) test in mice. Further, dopaminergic interaction of same doses of MPE in the FST and TST were checked by the administration of a haloperidol (0.1 mg/kg, i.p.) and bromocriptine (2 mg/kg, i.p.) on the 7(th) day of MPE treatment. Effect of MPE on locomotor activity was also checked using actophotometer. MPE produced a significant reduction of the immobility time in the FST and TST. Further, antidepressant action of MPE was significantly inhibited by haloperidol and potentiated by bromocriptine in the FST and TST. 21 days of MPE treatment produced protection in CUMS as indicated by a significant increase of sucrose intake of stressed mice. Locomotor activities of mice were not significantly changed after 1 h and 7(th) day of the MPE treatment. The results of this study indicate that hydroalcoholic extract of MPE have antidepressant action, which may be mediated by an interaction with the dopaminergic system.

  17. Malignant pleural effusion cell blocks are substitutes for tissue in EML4-ALK rearrangement detection in patients with advanced non-small-cell lung cancer.

    Science.gov (United States)

    Zhong, J; Li, X; Bai, H; Zhao, J; Wang, Z; Duan, J; An, T; Wu, M; Wang, Y; Wang, S; Wang, J

    2016-12-01

    To evaluate the feasibility of malignant pleural effusions (MPE) as surrogate samples for the detection of echinoderm microtubule-associated protein-like4 (EML4)-anaplastic lymphoma kinase (ALK) and to investigate the prognostic and predictive value of EML4-ALK in MPE of non-small-cell lung cancer (NSCLC). One hundred and nine NSCLC patients were retrospectively analysed. EML4-ALK was identified using paraffin-embedded tumour cells in MPE samples by immunohistochemistry (IHC, Ventana) and confirmed by fluorescence using in situ hybridisation (FISH) and qRT-PCR. The EGFR mutation was determined by MPE, using denaturing high-performance liquid chromatography (DHPLC). A total of 5 out of 109 (4.58%) patients were identified as EML4-ALK rearrangement in MPE by IHC.; In addition to two metachronous samples, the consistency of MPE and tissue for EML4-ALK detection was 100% (21/21), and the sensitivity and specificity were 100% (2/2) and 100% (19/19), respectively. EML4-ALK rearrangement cases were confirmed by FISH and qRT-PCR; the sensitivity were both 100% (2/2) when compared with tissue, and it was 60% (3/5) and 100% (5/5), respectively, when compared with MPE by IHC. The overall response rate (ORR) was 100% (2/2) for patients with EML4-ALK in MPE. Moreover, the PFS of these patients appeared to be prolonged in chemotherapy (9.27 versus 6.53 and versus 4.67 months, P = 0.122), compared with the EGFR mutation and the EGFR/ALK double negative group, respectively. EML4-ALK rearrangement detection in malignant pleural effusions is a complementary method for EML4-ALK detection. VETANA and qRT-PCR are more appropriate for MPE detection. EML4-ALK rearrangement in pleural effusions has a predictive value for treatment. © 2016 John Wiley & Sons Ltd.

  18. A comparative study to evaluate factors that influence survival in multidisciplinary predialysis educated patients and “Crashlanders”

    Directory of Open Access Journals (Sweden)

    Khairulsadek Zukmin

    2017-01-01

    Full Text Available Integrated multidisciplinary predialysis education (MPE is usually provided to support and prepare the pre-end-stage renal disease (ESRD patients before the initiation of renal replacement therapy (RRT. However, the impact of MPE is not known in our population, which is comprised patients of Asian origins and recipients of a totally subsidized health-care system. This research compared the survival probability, sociodemographic, and clinical characteristics of MPE patients and non-MPE patients (or crashlanders. A retrospective cohort study was conducted to investigate ESRD patients who started RRT in Brunei Darussalam from January 2013 to December 2014. Data were extracted from the computerized clinical database and dialysis records. A total of 351 new cases of ESRD patients who started on hemodialysis during the study period were included in the study. The median age was 56.0 years, with a slight male preponderance (56.6%. The MPE group was significantly older (P = 0.001 and more likely to have a history of diabetes mellitus (P = 0.013, ischemic heart disease (P = 0.014, and hypertension (P = 0.016. Despite being older and having more comorbidities (P = 0.028, MPE patients have a better survival probability (P = 0.028 and a 34% decreased risk of dying. Of those who died, older age (P = 0.001, higher serum creatinine (P = 0.01, and lower hemoglobin level (P = 0.017 were significant prognostic indicators. MPE before the initiation of RRT contributed to greater survival probability in near ESRD patients. The survival benefits were evident despite the presence of inherent risks (older age and presence of comorbidities in the MPE population in comparison with the non-MPE cohort.

  19. [Evaluation of the diagnosis value of carcinoembryonic antigen in malignant pleural effusion].

    Science.gov (United States)

    Yu, Y X; Tong, Z H; Zhou, X X; Liang, L R; Wang, Z; Xu, L L; Wang, X J; Wu, Y B; Li, H J; Lu, Z

    2018-02-06

    Objective: To investigate the diagnostic value of serum and pleural fluid carcinoembryonic antigen (CEA) for malignant pleural effusion (MPE). Methods: The concentration of CEA in serum and pleural fluid of 286 patients with the diagnosis confirmed by pleural biopsy through medical thoracoscopy were retrospectively analyzed. MPE was confirmed in 171 cases which were divided into two groups (adenocarcinoma group with 121cases and non-adenocarcinoma group with 50 cases) and benign pleural effusion in 115 cases. The optimal cutoff for MPE and MPE caused by adenocarcinoma were determined by using the ROC curve. Results: The concentration of serum CEA 12.27(3.80, 58.45) μg/L was significantly higher in MPE caused by adenocarcinoma than that of non-adenocarcinoma 1.91(1.08, 4.55) μg/L and benign effusion 1.32(0.86, 2.27) μg/L (both P value of serum and pleural fluid CEA for MPE was 3.10 and 5.83 μg/L, the sensitivity respectively was 67.3% and 74.3%, the specificity respectively was 87.8% and 98.3%, positive predictive value respectively was 89.2% and 98.5%, negative predictive value respectively was 64.3% and 72.0%. The cutoff value of serum and pleural fluid CEA for MPE caused by adenocarcinoma was 3.54 and 7.30 μg/L, the sensitivity respectively was 76.0% and 91.7%, the specificity respectively was 74.0% and 72.0%, positive predictive value respectively was 87.6% and 88.8%, negative predictive value respectively was 56.1% and 78.3%. Conclusions: The concentration of serum and pleural fluid CEA have diagnostic significance to MPE, especially MPE caused by adenocarcinoma. The diagnostic value of pleural fluid CEA is superior to serum CEA.

  20. Combination of long noncoding RNA MALAT1 and carcinoembryonic antigen for the diagnosis of malignant pleural effusion caused by lung cancer.

    Science.gov (United States)

    Wang, Wan-Wei; Zhou, Xi-Lei; Song, Ying-Jian; Yu, Chang-Hua; Zhu, Wei-Guo; Tong, Yu-Suo

    2018-01-01

    Long noncoding RNAs (lncRNAs) are present in body fluids, but their potential as tumor biomarkers has never been investigated in malignant pleural effusion (MPE) caused by lung cancer. The aim of this study was to assess the clinical significance of lncRNAs in pleural effusion, which could potentially serve as diagnostic and predictive markers for lung cancer-associated MPE (LC-MPE). RNAs from pleural effusion were extracted in 217 cases of LC-MPE and 132 cases of benign pleural effusion (BPE). Thirty-one lung cancer-associated lncRNAs were measured using quantitative real-time polymerase chain reaction (qRT-PCR). The level of carcinoembryonic antigen (CEA) was also determined. The receiver operating characteristic (ROC) curves and the area under the ROC curve (AUC) were established to evaluate the sensitivity and specificity of the identified lncRNAs and other biomarkers. The correlations between baseline pleural effusion lncRNAs expression and response to chemotherapy were also analyzed. Three lncRNAs ( MALAT1 , H19 , and CUDR ) were found to have potential as diagnostic markers in LC-MPE. The AUCs for MALAT1 , H19 , CUDR , and CEA were 0.891, 0.783, 0.824, and 0.826, respectively. Using a logistic model, the combination of MALAT1 and CEA (AUC, 0.924) provided higher sensitivity and accuracy in predicting LC-MPE than CEA (AUC, 0.826) alone. Moreover, baseline MALAT1 expression in pleural fluid was inversely correlated with chemotherapy response in patients with LC-MPE. Pleural effusion lncRNAs were effective in differentiating LC-MPE from BPE. The combination of MALAT1 and CEA was more effective for LC-MPE diagnosis.

  1. Development of a modal model for the description of the chemistry and physics of clouds and aerosols and whose implementation in the EURAD-model-system for the description of modifications of the actinic flux caused by aerosols. Final report; Entwicklung eines modalen Modells zur Beschreibung der Chemie und Physik von Wolken und Aerosolen und dessen Implementierung in das EURAD-Modellsystem zur Beschreibung aerosolbedingter Modifikationen des aktinischen Flusses. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Friese, E.; Memmesheimer, M.; Ebel, A.; Kerschgens, M.

    2001-07-01

    In cooperation with the Ford Research Center Aachen a trimodal version of the Modal Aerosol Dynamics Model for Europe (MADE) has been developed further and implemented into the EURAD model system. Model components for aerosol cloud interactions and secondary organic aerosols have implemented. Parameterizations of aerosol cloud interactions have verified in cooperation with the Institut fuer Troposphaerenforschung (IFT) and the university of Cottbus (BTU). Model results for episodes in summertime and wintertime 1997 have compared with measurements of PM{sub 10}-concentrations from the department of the environment of Northrine-Westfalia. Inside the area of Northrine-Westfalia the modelled PM{sub 10}-concentrations are largely in agreement with the assessment principles for air quality models recommended by the European Union. Modelled sulphate and TSP-concentrations have compared with measurements at stations from the EMEP network. The developed aerosol dynamics model is useful for the realization and control of air quality directives passed by the European Union. The numerical simulation of modifications of the Actinic flux caused by aerosols have prepared. Technical problems remain concerning the numerical description of the size-composition distribution of cloud droplets. Furthermore the determination of the soot fraction of aerosol particles is very uncertain at the moment. For this reasons an implementation of the numerical simulation of modifications of the Actinic flux caused by aerosol particles have put on the back burner. (orig.) [German] In Kooperation mit dem Ford Forschungszentrum Aachen (FFA) wurde eine trimodale Version des Modalen Aerosol-Dynamik Modells fuer Europa (MADE) in das EURAD-Modellsystem implementiert und weiterentwickelt. Weiterhin wurden Module fuer die Wechselwirkungen von Aerosolen und Wolken sowie zur Bildung von sekundaerem organischen Aerosol implementiert. Die Funktionsfaehigkeit dieser Module wurde mit Modellrechnungen ueberprueft. Dem Wolkenmodul zugrundeliegende Annahmen konnten in Zusammenarbeit mit dem Institut fuer Troposphaerenforschung (IFT, Leipzig) und der Universitaet Cottbus (BTU) ueberprueft werden. Durch Vergleiche zwischen prognostizierten PM{sub 10}-Konzentrationen und Messungen an Stationen des Landesumweltamtes Nordrhein-Westfalen wurde das Aerosol-Dynamik Modell fuer Episoden im Sommer und Winter 1997 validiert. Die Validierung zeigt, dass die prognostizierten Aerosolkonzentrationen im Gebiet von Nordrhein Westfalen groesstenteils innerhalb der Toleranzen liegen, die von der Europaeischen Union als Bewertungskriterien fuer Luftschadstoffmodelle vorgegeben wurden. Eine weitere Validierung, die ueber das Gebiet von Nordrhein-Westfalen hinaus reicht, wurde mit Hilfe von Messungen der Sulfat- und Schwebstaubkonzentrationen an EMEP Stationen durchgefuehrt. Damit liegt ein Aerosol-Dynamik-Modell vor, das bereits routinemaessig innerhalb des EURAD Modellsystems eingesetzt wird und sich fuer den Einsatz bei der Umsetzung von Richtlinien der EU zur Luftqualitaet eignet. Vorbereitende Massnahmen zur Beschreibung aerosolbedingter Modifikationen des aktinischen Flusses wurden durchgefuehrt. Ihre Umsetzung erscheint zum gegenwaertigen Zeitpunkt aufgrund von technischen Problemen bei der numerischen Simulation der chemischen Zusammensetzung und Groessenverteilung von Wolkentropfen sowie des Kohlenstoffanteils von Aerosolpartikeln verfrueht. (orig.)

  2. Identification of the chlE gene encoding oxygen-independent Mg-protoporphyrin IX monomethyl ester cyclase in cyanobacteria.

    Science.gov (United States)

    Yamanashi, Kaori; Minamizaki, Kei; Fujita, Yuichi

    2015-08-07

    The fifth ring (E-ring) of chlorophyll (Chl) a is produced by Mg-protoporphyrin IX monomethyl ester (MPE) cyclase. There are two evolutionarily unrelated MPE cyclases: oxygen-independent (BchE) and oxygen-dependent (ChlA/AcsF) MPE cyclases. Although ChlA is the sole MPE cyclase in Synechocystis PCC 6803, it is yet unclear whether BchE exists in cyanobacteria. A BLAST search suggests that only few cyanobacteria possess bchE. Here, we report that two bchE candidate genes from Cyanothece strains PCC 7425 and PCC 7822 restore the photosynthetic growth and bacteriochlorophyll production in a bchE-lacking mutant of Rhodobacter capsulatus. We termed these cyanobacterial bchE orthologs "chlE." Copyright © 2015 Elsevier Inc. All rights reserved.

  3. Damage Threshold of In Vivo Rabbit Cornea by 2 micron Laser Irradiation

    National Research Council Canada - National Science Library

    Chen, Bo; Oliver, Jeffery; Dutta, Soumak; Rylander, III, Grady H; Thomsen, Sharon L; Welch, Ashley J

    2007-01-01

    To support refinement of the Maximum Permissible Exposure (MPE) safety limits, a series of experiments were conducted in vivo on Dutch Belted rabbit corneas to determine corneal minimum visible lesion thresholds...

  4. Mucuna pruriens (Velvet bean) rescues motor, olfactory, mitochondrial and synaptic impairment in PINK1B9 Drosophila melanogaster genetic model of Parkinson's disease.

    Science.gov (United States)

    Poddighe, Simone; De Rose, Francescaelena; Marotta, Roberto; Ruffilli, Roberta; Fanti, Maura; Secci, Pietro Paolo; Mostallino, Maria Cristina; Setzu, Maria Dolores; Zuncheddu, Maria Antonietta; Collu, Ignazio; Solla, Paolo; Marrosu, Francesco; Kasture, Sanjay; Acquas, Elio; Liscia, Anna

    2014-01-01

    The fruit fly Drosophila melanogaster (Dm) mutant for PTEN-induced putative kinase 1 (PINK1B9) gene is a powerful tool to investigate physiopathology of Parkinson's disease (PD). Using PINK1B9 mutant Dm we sought to explore the effects of Mucuna pruriens methanolic extract (Mpe), a L-Dopa-containing herbal remedy of PD. The effects of Mpe on PINK1B9 mutants, supplied with standard diet to larvae and adults, were assayed on 3-6 (I), 10-15 (II) and 20-25 (III) days old flies. Mpe 0.1% significantly extended lifespan of PINK1B9 and fully rescued olfactory response to 1-hexanol and improved climbing behavior of PINK1B9 of all ages; in contrast, L-Dopa (0.01%, percentage at which it is present in Mpe 0.1%) ameliorated climbing of only PINK1B9 flies of age step II. Transmission electron microscopy analysis of antennal lobes and thoracic ganglia of PINK1B9 revealed that Mpe restored to wild type (WT) levels both T-bars and damaged mitochondria. Western blot analysis of whole brain showed that Mpe, but not L-Dopa on its own, restored bruchpilot (BRP) and tyrosine hydroxylase (TH) expression to age-matched WT control levels. These results highlight multiple sites of action of Mpe, suggesting that its effects cannot only depend upon its L-Dopa content and support the clinical observation of Mpe as an effective medication with intrinsic ability of delaying the onset of chronic L-Dopa-induced long-term motor complications. Overall, this study strengthens the relevance of using PINK1B9 Dm as a translational model to study the properties of Mucuna pruriens for PD treatment.

  5. Mucuna pruriens (Velvet bean) Rescues Motor, Olfactory, Mitochondrial and Synaptic Impairment in PINK1B9 Drosophila melanogaster Genetic Model of Parkinson’s Disease

    Science.gov (United States)

    Ruffilli, Roberta; Fanti, Maura; Secci, Pietro Paolo; Mostallino, Maria Cristina; Setzu, Maria Dolores; Zuncheddu, Maria Antonietta; Collu, Ignazio; Solla, Paolo; Marrosu, Francesco; Kasture, Sanjay; Acquas, Elio; Liscia, Anna

    2014-01-01

    The fruit fly Drosophila melanogaster (Dm) mutant for PTEN-induced putative kinase 1 (PINK1B9) gene is a powerful tool to investigate physiopathology of Parkinson's disease (PD). Using PINK1B9 mutant Dm we sought to explore the effects of Mucuna pruriens methanolic extract (Mpe), a L-Dopa-containing herbal remedy of PD. The effects of Mpe on PINK1B9 mutants, supplied with standard diet to larvae and adults, were assayed on 3–6 (I), 10–15 (II) and 20–25 (III) days old flies. Mpe 0.1% significantly extended lifespan of PINK1B9 and fully rescued olfactory response to 1-hexanol and improved climbing behavior of PINK1B9 of all ages; in contrast, L-Dopa (0.01%, percentage at which it is present in Mpe 0.1%) ameliorated climbing of only PINK1B9 flies of age step II. Transmission electron microscopy analysis of antennal lobes and thoracic ganglia of PINK1B9 revealed that Mpe restored to wild type (WT) levels both T-bars and damaged mitochondria. Western blot analysis of whole brain showed that Mpe, but not L-Dopa on its own, restored bruchpilot (BRP) and tyrosine hydroxylase (TH) expression to age-matched WT control levels. These results highlight multiple sites of action of Mpe, suggesting that its effects cannot only depend upon its L-Dopa content and support the clinical observation of Mpe as an effective medication with intrinsic ability of delaying the onset of chronic L-Dopa-induced long-term motor complications. Overall, this study strengthens the relevance of using PINK1B9 Dm as a translational model to study the properties of Mucuna pruriens for PD treatment. PMID:25340511

  6. Mucuna pruriens (Velvet bean rescues motor, olfactory, mitochondrial and synaptic impairment in PINK1B9 Drosophila melanogaster genetic model of Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Simone Poddighe

    Full Text Available The fruit fly Drosophila melanogaster (Dm mutant for PTEN-induced putative kinase 1 (PINK1B9 gene is a powerful tool to investigate physiopathology of Parkinson's disease (PD. Using PINK1B9 mutant Dm we sought to explore the effects of Mucuna pruriens methanolic extract (Mpe, a L-Dopa-containing herbal remedy of PD. The effects of Mpe on PINK1B9 mutants, supplied with standard diet to larvae and adults, were assayed on 3-6 (I, 10-15 (II and 20-25 (III days old flies. Mpe 0.1% significantly extended lifespan of PINK1B9 and fully rescued olfactory response to 1-hexanol and improved climbing behavior of PINK1B9 of all ages; in contrast, L-Dopa (0.01%, percentage at which it is present in Mpe 0.1% ameliorated climbing of only PINK1B9 flies of age step II. Transmission electron microscopy analysis of antennal lobes and thoracic ganglia of PINK1B9 revealed that Mpe restored to wild type (WT levels both T-bars and damaged mitochondria. Western blot analysis of whole brain showed that Mpe, but not L-Dopa on its own, restored bruchpilot (BRP and tyrosine hydroxylase (TH expression to age-matched WT control levels. These results highlight multiple sites of action of Mpe, suggesting that its effects cannot only depend upon its L-Dopa content and support the clinical observation of Mpe as an effective medication with intrinsic ability of delaying the onset of chronic L-Dopa-induced long-term motor complications. Overall, this study strengthens the relevance of using PINK1B9 Dm as a translational model to study the properties of Mucuna pruriens for PD treatment.

  7. Single center experience on talc poudrage morbidity: focus on high talc dosage

    Directory of Open Access Journals (Sweden)

    Congedo Maria

    2011-06-01

    Full Text Available Abstract Malignant pleural effusion (MPE is a common clinical problem of concern for most of the pneumologists and thoracic surgeons. A general consensus regarding the use of talc poudrage in treatment of MPE exists, but only few studies analyzed in detail talc insufflation related pulmonary morbidity. In particular, ARDS talc-related is caused by physical and chemical effects of the small talc particles (50% particle size

  8. Quantenfeldtheorie wie man beschreibt, was die Welt im Innersten zusammenhält

    CERN Document Server

    Fritzsch, Harald

    2015-01-01

    Die Geheimnisse des Mikrokosmos aufzudecken, hat die Physiker seit Jahrhunderten fasziniert. Doch obwohl in den vergangenen Jahrzehnten viele interessante Entdeckungen gemacht wurden, bleiben noch Fragen offen, die Harald Fritzsch in diesem Buch von der physikalischen und mathematischen Seite beleuchtet: - Haben die Physiker mit der Standardtheorie der Elementarteilchenphysik schon eine exakte Beschreibung der Teilchenwelt gefunden? - Gibt es wirklich eine „Große Vereinigung“ aller fundamentalen Kräfte? - Und sind die Leptonen, (wie das Elektron), oder die Bausteine der Hadronen, (die Quarks), vielleicht gar nicht wirklich punktförmig, sondern kleine eindimensionale Objekte, die man als „Strings“ bezeichnet? Dieses Buch setzt mathematische Vorbildung voraus und versteht sich als Überblick über die modernen Grundlagen der Quantenfeldtheorie und als Diskussionsbeitrag. Somit eignet sich das Werk insbesondere auch als Überblick und Wiederholung für Physiker. Harald Fritzsch ist bereits als Auto...

  9. Mast cells mediate malignant pleural effusion formation.

    Science.gov (United States)

    Giannou, Anastasios D; Marazioti, Antonia; Spella, Magda; Kanellakis, Nikolaos I; Apostolopoulou, Hara; Psallidas, Ioannis; Prijovich, Zeljko M; Vreka, Malamati; Zazara, Dimitra E; Lilis, Ioannis; Papaleonidopoulos, Vassilios; Kairi, Chrysoula A; Patmanidi, Alexandra L; Giopanou, Ioanna; Spiropoulou, Nikolitsa; Harokopos, Vaggelis; Aidinis, Vassilis; Spyratos, Dionisios; Teliousi, Stamatia; Papadaki, Helen; Taraviras, Stavros; Snyder, Linda A; Eickelberg, Oliver; Kardamakis, Dimitrios; Iwakura, Yoichiro; Feyerabend, Thorsten B; Rodewald, Hans-Reimer; Kalomenidis, Ioannis; Blackwell, Timothy S; Agalioti, Theodora; Stathopoulos, Georgios T

    2015-06-01

    Mast cells (MCs) have been identified in various tumors; however, the role of these cells in tumorigenesis remains controversial. Here, we quantified MCs in human and murine malignant pleural effusions (MPEs) and evaluated the fate and function of these cells in MPE development. Evaluation of murine MPE-competent lung and colon adenocarcinomas revealed that these tumors actively attract and subsequently degranulate MCs in the pleural space by elaborating CCL2 and osteopontin. MCs were required for effusion development, as MPEs did not form in mice lacking MCs, and pleural infusion of MCs with MPE-incompetent cells promoted MPE formation. Once homed to the pleural space, MCs released tryptase AB1 and IL-1β, which in turn induced pleural vasculature leakiness and triggered NF-κB activation in pleural tumor cells, thereby fostering pleural fluid accumulation and tumor growth. Evaluation of human effusions revealed that MCs are elevated in MPEs compared with benign effusions. Moreover, MC abundance correlated with MPE formation in a human cancer cell-induced effusion model. Treatment of mice with the c-KIT inhibitor imatinib mesylate limited effusion precipitation by mouse and human adenocarcinoma cells. Together, the results of this study indicate that MCs are required for MPE formation and suggest that MC-dependent effusion formation is therapeutically addressable.

  10. Extração e pré-concentração de compostos orgânicos voláteis por permeação em membrana para análise cromatográfica Extraction and pre-concentration of volatile organic compounds by membrane permeation for chromatography analysis

    Directory of Open Access Journals (Sweden)

    Eduardo Carasek da Rocha

    2000-02-01

    Full Text Available This work discusses sample preparation processes for gas chromatography (GC based on the technique of extraction through membrane permeation (MPE. The MPE technique may be easily coupled to GC via a relatively simple device, which is a module that holds the membrane and is directly connected to the GC column. The possibility of operational errors due to sample handling is substantially reduced in an MPE-GC system because the sample preparation and the chemical analysis are accomplished as a one-step process. The MPE technique is of relatively wide application as it can be used for aqueous samples, solid samples and gaseous samples. Depending on the type of sample the extraction is performed with the membrane in direct contact with the sample or in contact with its headspace. The MPE-GC technique is very useful in trace analysis, due to the time-dependent enrichment of the analyte. A typical application of MPE-GC is the analysis of VOCs present in water that may be accomplished with detection limits at the low ppb (mugL-1 level.

  11. Cytokeratin positivity in myxopapillary ependymoma – a potential diagnostic pitfall

    Directory of Open Access Journals (Sweden)

    Sur Monalisa

    2008-10-01

    Full Text Available Abstract Background Myxopapillary ependymomas (MPE occur in the filum terminale of the spinal cord, but also present in extra-spinal locations such as subcutaneous tissue and brain. They are slow growing grade I gliomas. Areas of solid growth pattern with aggregates of cells with "epithelioid morphology" seen in MPE can mimic metastatic carcinoma. The presence of occasional cells with clear cytoplasm and morphology can resemble Chordoma. Diagnosis can be missed due to these morphological similarities, which could affect patient management and hence, long term survival. Case presentation We describe two cases of MPE with cytokeratin (AE1 AE3, CAM 5.2, Cytokeratin 7 and cytokeratin 20 expression. Conclusion MPE can be positive for Cytokeratins (CAM 5.2, AE1 AE3, CK7 and focally for EMA, which could be misdiagnosed as metastatic carcinoma. In cases demonstrating epithelioid and clear cell morphology, the diagnosis of MPE should be made in conjunction with histology, proper immunohistochemical profile which includes co-expression of GFAP, S-100 protein and epithelial markers, radiologic findings and site. It is important to be aware of the cytokeratin profile in MPE to avoid erroneous diagnosis with other tumour entities.

  12. Effect of Mucuna pruriens Seed Extract Pretreatment on the Responses of Spontaneously Beating Rat Atria and Aortic Ring to Naja sputatrix (Javan Spitting Cobra) Venom

    Science.gov (United States)

    Fung, Shin Yee; Tan, Nget Hong; Sim, Si Mui; Aguiyi, John C.

    2012-01-01

    Mucuna pruriens Linn. (velvet bean) has been used by native Nigerians as a prophylactic for snakebite. Rats pretreated with M. pruriens seed extract (MPE) have been shown to protect against the lethal and cardiovascular depressant effects of Naja sputatrix (Javan spitting cobra) venoms, and the protective effect involved immunological neutralization of the venom toxins. To investigate further the mechanism of the protective effect of MPE pretreatment against cobra venom toxicity, the actions of Naja sputatrix venom on spontaneously beating rat atria and aortic rings isolated from both MPE pretreated and untreated rats were studied. Our results showed that the MPE pretreatment conferred protection against cobra venom-induced depression of atrial contractility and atrial rate in the isolated atrial preparations, but it had no effect on the venom-induced contractile response of aortic ring preparation. These observations suggested that the protective effect of MPE pretreatment against cobra venom toxicity involves a direct protective action of MPE on the heart function, in addition to the known immunological neutralization mechanism, and that the protective effect does not involve action on blood vessel contraction. The results also suggest that M. pruriens seed may contain novel cardioprotective agent with potential therapeutic value. PMID:21785646

  13. The protective effect of Mucuna pruriens seeds against snake venom poisoning.

    Science.gov (United States)

    Tan, Nget Hong; Fung, Shin Yee; Sim, Si Mui; Marinello, Enrico; Guerranti, Roberto; Aguiyi, John C

    2009-06-22

    The seed, leaf and root of Mucuna pruriens have been used in traditional medicine for treatments of various diseases. In Nigeria, the seed is used as oral prophylactics for snakebite. To study the protective effects of Mucuna pruriens seed extract against the lethalities of various snake venoms. Rats were pre-treated with Mucuna pruriens seed extract and challenged with various snake venoms. The effectiveness of anti-Mucuna pruriens (anti-MPE) antibody to neutralize the lethalities of snake venoms was investigated by in vitro neutralization. In rats, MPE pre-treatment conferred effective protection against lethality of Naja sputatrix venom and moderate protection against Calloselasma rhodostoma venom. Indirect ELISA and immunoblotting studies showed that there were extensive cross-reactions between anti-MPE IgG and venoms from many different genera of poisonous snakes, suggesting the involvement of immunological neutralization in the protective effect of MPE pre-treatment against snake venom poisoning. In vitro neutralization experiments showed that the anti-MPE antibodies effectively neutralized the lethalities of Asiatic cobra (Naja) venoms, but were not very effective against other venoms tested. The anti-MPE antibodies could be used in the antiserum therapy of Asiatic cobra (Naja) bites.

  14. Differential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS

    Science.gov (United States)

    De Rose, Francescaelena; Marotta, Roberto; Talani, Giuseppe; Catelani, Tiziano; Solari, Paolo; Poddighe, Simone; Borghero, Giuseppe; Marrosu, Francesco; Sanna, Enrico; Kasture, Sanjay; Acquas, Elio; Liscia, Anna

    2017-01-01

    The present study was aimed at characterizing the effects of Withania somnifera (Wse) and Mucuna pruriens (Mpe) on a Drosophila melanogaster model for Amyotrophic Lateral Sclerosis (ALS). In particular, the effects of Wse and Mpe were assessed following feeding the flies selectively overexpressing the wild human copper, zinc-superoxide dismutase (hSOD1-gain-of-function) in Drosophila motoneurons. Although ALS-hSOD1 mutants showed no impairment in life span, with respect to GAL4 controls, the results revealed impairment of climbing behaviour, muscle electrophysiological parameters (latency and amplitude of ePSPs) as well as thoracic ganglia mitochondrial functions. Interestingly, Wse treatment significantly increased lifespan of hSDO1 while Mpe had not effect. Conversely, both Wse and Mpe significantly rescued climbing impairment, and also latency and amplitude of ePSPs as well as failure responses to high frequency DLM stimulation. Finally, mitochondrial alterations were any more present in Wse- but not in Mpe-treated hSOD1 mutants. Hence, given the role of inflammation in the development of ALS, the high translational impact of the model, the known anti-inflammatory properties of these extracts, and the viability of their clinical use, these results suggest that the application of Wse and Mpe might represent a valuable pharmacological strategy to counteract the progression of ALS and related symptoms. PMID:28102336

  15. Effect of Mucuna pruriens Seed Extract Pretreatment on the Responses of Spontaneously Beating Rat Atria and Aortic Ring to Naja sputatrix (Javan Spitting Cobra Venom

    Directory of Open Access Journals (Sweden)

    Shin Yee Fung

    2012-01-01

    Full Text Available Mucuna pruriens Linn. (velvet bean has been used by native Nigerians as a prophylactic for snakebite. Rats pretreated with M. pruriens seed extract (MPE have been shown to protect against the lethal and cardiovascular depressant effects of Naja sputatrix (Javan spitting cobra venoms, and the protective effect involved immunological neutralization of the venom toxins. To investigate further the mechanism of the protective effect of MPE pretreatment against cobra venom toxicity, the actions of Naja sputatrix venom on spontaneously beating rat atria and aortic rings isolated from both MPE pretreated and untreated rats were studied. Our results showed that the MPE pretreatment conferred protection against cobra venom-induced depression of atrial contractility and atrial rate in the isolated atrial preparations, but it had no effect on the venom-induced contractile response of aortic ring preparation. These observations suggested that the protective effect of MPE pretreatment against cobra venom toxicity involves a direct protective action of MPE on the heart function, in addition to the known immunological neutralization mechanism, and that the protective effect does not involve action on blood vessel contraction. The results also suggest that M. pruriens seed may contain novel cardioprotective agent with potential therapeutic value.

  16. 3-MCPD 1-Palmitate Induced Tubular Cell Apoptosis In Vivo via JNK/p53 Pathways

    Science.gov (United States)

    Liu, Man; Huang, Guoren; Wang, Thomas T.Y.; Sun, Xiangjun; Yu, Liangli (Lucy)

    2016-01-01

    Fatty acid esters of 3-chloro-1, 2-propanediol (3-MCPD esters) are a group of processing induced food contaminants with nephrotoxicity but the molecular mechanism(s) remains unclear. This study investigated whether and how the JNK/p53 pathway may play a role in the nephrotoxic effect of 3-MCPD esters using 3-MCPD 1-palmitate (MPE) as a probe compound in Sprague Dawley rats. Microarray analysis of the kidney from the Sprague Dawley rats treated with MPE, using Gene Ontology categories and KEGG pathways, revealed that MPE altered mRNA expressions of the genes involved in the mitogen-activated protein kinase (JNK and ERK), p53, and apoptotic signal transduction pathways. The changes in the mRNA expressions were confirmed by qRT-PCR and Western blot analyses and were consistent with the induction of tubular cell apoptosis as determined by histopathological, TUNEL, and immunohistochemistry analyses in the kidneys of the Sprague Dawley rats. Additionally, p53 knockout attenuated the apoptosis, and the apoptosis-related protein bax expression and cleaved caspase-3 activation induced by MPE in the p53 knockout C57BL/6 mice, whereas JNK inhibitor SP600125 but not ERK inhibitor U0126 inhibited MPE-induced apoptosis, supporting the conclusion that JNK/p53 might play a critical role in the tubular cell apoptosis induced by MPE and other 3-MCPD fatty acid esters. PMID:27008853

  17. Void fraction correlations analysis and their influence on heat transfer of helical double-pipe vertical evaporator

    International Nuclear Information System (INIS)

    Parrales, Arianna; Colorado, Dario; Huicochea, Armando; Díaz, Juan; Alfredo Hernández, J.

    2014-01-01

    Highlights: • 50 void fraction correlations were evaluated on heat transfer in vertical evaporators. • Two-phase flow model based on control volume formulation was used. • The drift flux parameter is common in all correlations with satisfactory results. - Abstract: An analysis of 50 void fraction correlations available in the literature was performed to describe two-phase flow mechanism inside two helical double-pipe vertical evaporators. The evaporators considered water as working fluid connected in countercurrent so the change of phase was carried out into the internal tube. The discretized equations of continuity, momentum and energy in each flow were coupled using an implicit step by step method. The selection of the void fraction correlations for the mathematical model was based on inclusion of some theoretical limits. The results of this analysis were compared with the experimental data in steady state for two different evaporators, obtaining good agreement in the evaporation process for only 7 void fraction correlations. The Armand and Massena correlation had a mean percentage error (MPE) of 3.08%, followed by Rouhanni and Axelsson I adquired MPE=3.16%, Chisholm and Armand obtained MPE=3.18%, Steiner as well as Rouhanni and Axelsson II with MPE=3.19%, Bestion reached MPE=3.20% and Flanigan presented MPE=3.21%. Furthermore, the experimental and simulated heat flux were acceptable (R 2 =0.939). Finally, the results showed that the drift flux parameter was important to evaluate the void fraction

  18. Prognostic Significance of Blood, Serum, and Ascites Parameters in Patients with Malignant Peritoneal Mesothelioma or Peritoneal Carcinomatosis.

    Science.gov (United States)

    Su, Shan-Shan; Zheng, Guo-Qi; Yin, Wen-Jie; Liang, Yu-Fei; Liu, Ying-Ying; Song, Hui; Sun, Ning-Ning; Yang, Yu-Xin

    2018-01-01

    To determine effects of the biochemical and cytological properties of blood, serum, and ascites on survival of patients with malignant peritoneal effusion (MPeE), including malignant peritoneal mesothelioma (MPeM) and peritoneal carcinomatosis (PC), we conducted a retrospective study of patients with MPeE and healthy controls. Potential prognostic factors were identified as follows: age, sex, blood neutrophil-to-lymphocyte ratio (NLR), serum parameters, ascites parameters, serum-ascites albumin gradient, and the ascites-serum LDH ratio. Compared to those of the control group, serum albumin levels were significantly lower, and the NLR and serum LDH levels were significantly higher in the MPeE group. Overall survival (OS) was longer in patients with MPeM compared to that in patients with PC. Compared with patients in the MPeM, patients with PC had higher NLRs, ascites glucose levels, serum-ascites albumin gradients, and serum LDH levels. In contrast, their ascites albumin levels and ascites-serum LDH ratios were lower. Univariate analyses indicated that the NLR, serum LDH levels, ascites LDH levels, ascites coenocyte levels, and the ascites coenocyte-to-monocyte ratios affected the OS. Multivariate analyses identified only serum and ascites LDH levels as independent prognostic factors.

  19. Diagnosis and management options in malignant pleural effusions

    Science.gov (United States)

    Dixit, Ramakant; Agarwal, KC; Gokhroo, Archana; Patil, Chetan B; Meena, Manoj; Shah, Narender S; Arora, Piyush

    2017-01-01

    Malignant pleural effusion (MPE) denotes an advanced malignant disease process. Most of the MPE are metastatic involvement of the pleura from primary malignancy at lung, breast, and other body sites apart from lymphomas. The diagnosis of MPE has been traditionally made on cytological examination of pleural fluid and/or histological examination of pleural biopsy tissue that still remains the initial approach in these cases. There has been tremendous advancement in the diagnosis of MPE now a day with techniques i.e. characteristic Ultrasound and computed tomography features, image guided biopsies, fluorodeoxyglucose-positron emission tomography imaging, thoracoscopy with direct biopsy under vision, tumor marker studies and immunocytochemical analysis etc., that have made possible an early diagnosis of MPE. The management of MPE still remains a challenge to pulmonologist and oncologist. Despite having various modalities with better tolerance such as pleurodesis and indwelling pleural catheters etc., for long-term control, all the management approaches remain palliative to improve the quality of life and reduce symptoms. While choosing an appropriate management intervention, one should consider the clinical status of the patient, life expectancy, overall cost, availability and comparative institutional outcomes, etc. PMID:28360465

  20. Switching off malignant pleural effusion formation—fantasy or future?

    Science.gov (United States)

    Giannou, Anastasios D.; Stathopoulos, Georgios T.

    2015-01-01

    Malignant pleural effusion (MPE) is common and difficult to treat. In the vast majority of patients the presence of MPE heralds incurable disease, associated with poor quality of life, morbidity and mortality. Current therapeutic approaches are inefficient and merely offer palliation of associated symptoms. Recent scientific progress has shed light in the biologic processes governing the mechanisms behind the pathobiology of MPE. Pleural based tumors interfere with pleural fluid drainage, as well as the host vasculature and immune system, resulting in decreased fluid absorption and increased pleural fluid production via enhanced plasma extravasation into the pleural space. In order to achieve this feat, pleural based tumors must elicit critical vasoactive events in the pleura, thus forming a favorable microenvironment for tumor dissemination and MPE development. Such properties involve specific transcriptional signaling cascades in addition to secretion of important mediators which attract and activate host cell populations which, in turn, impact tumor cell functions. The dissection of the biologic steps leading to MPE formation provides novel therapeutic targets and recent research findings provide encouraging results towards future therapeutic innovations in MPE management. PMID:26150914

  1. Diagnosis and management options in malignant pleural effusions

    Directory of Open Access Journals (Sweden)

    Ramakant Dixit

    2017-01-01

    Full Text Available Malignant pleural effusion (MPE denotes an advanced malignant disease process. Most of the MPE are metastatic involvement of the pleura from primary malignancy at lung, breast, and other body sites apart from lymphomas. The diagnosis of MPE has been traditionally made on cytological examination of pleural fluid and/or histological examination of pleural biopsy tissue that still remains the initial approach in these cases. There has been tremendous advancement in the diagnosis of MPE now a day with techniques i.e. characteristic Ultrasound and computed tomography features, image guided biopsies, fluorodeoxyglucose-positron emission tomography imaging, thoracoscopy with direct biopsy under vision, tumor marker studies and immunocytochemical analysis etc., that have made possible an early diagnosis of MPE. The management of MPE still remains a challenge to pulmonologist and oncologist. Despite having various modalities with better tolerance such as pleurodesis and indwelling pleural catheters etc., for long-term control, all the management approaches remain palliative to improve the quality of life and reduce symptoms. While choosing an appropriate management intervention, one should consider the clinical status of the patient, life expectancy, overall cost, availability and comparative institutional outcomes, etc.

  2. Vascular endothelial growth factor and protein level in pleural effusion for differentiating malignant from benign pleural effusion.

    Science.gov (United States)

    Wu, Da-Wei; Chang, Wei-An; Liu, Kuan-Ting; Yen, Meng-Chi; Kuo, Po-Lin

    2017-09-01

    Pleural effusion is associated with multiple benign and malignant conditions. Currently no biomarkers differentiate malignant pleural effusion (MPE) and benign pleural effusion (BPE) sensitively and specifically. The present study identified a novel combination of biomarkers in pleural effusion for differentiating MPE from BPE by enrolling 75 patients, 34 with BPE and 41 with MPE. The levels of lactate dehydrogenase, glucose, protein, and total cell, neutrophil, monocyte and lymphocyte counts in the pleural effusion were measured. The concentrations of interleukin (IL)-1β, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor-α, interferon γ, transforming growth factor-β1, colony stimulating factor 2, monocyte chemoattractant protein-1 and vascular endothelial growth factor (VEGF) were detected using cytometric bead arrays. Protein and VEGF levels differed significantly between patients with BPE and those with MPE. The optimal cutoff value of VEGF and protein was 214 pg/ml and 3.35 g/dl respectively, according to the receiver operating characteristic curve. A combination of VEGF >214 pg/ml and protein >3.35 g/dl in pleural effusion presented a sensitivity of 92.6% and an accuracy of 78.6% for MPE, but was not associated with a decreased survival rate. These results suggested that this novel combination strategy may provide useful biomarkers for predicting MPE and facilitating early diagnosis.

  3. Infrared Images of an Infant Solar System

    Science.gov (United States)

    2002-05-01

    . Grosso and co-authors). Notes [1]: The team consists of Nicolas Grosso (Max-Planck-Institut für extraterrestrische Physik, Garching, Germany), João Alves (ESO, Garching, Germany), Kenneth Wood (School of Physics & Astronomy, University of St Andrews, Scotland, UK), Ralph Neuhäuser (Max-Planck-Institut für extraterrestrische Physik, Garching, Germany), Thierry Montmerle (Service d'Astrophysique, CEA Saclay,Gif-sur-Yvette, France) and Jon E. Bjorkman (Ritter Observatory, Department of Physics & Astronomy, University of Toledo, Ohio, USA).

  4. A water extract of Mucuna pruriens provides long-term amelioration of parkinsonism with reduced risk for dyskinesias.

    Science.gov (United States)

    Lieu, Christopher A; Kunselman, Allen R; Manyam, Bala V; Venkiteswaran, Kala; Subramanian, Thyagarajan

    2010-08-01

    Dopaminergic anti-parkinsonian medications, such as levodopa (LD) cause drug-induced dyskinesias (DID) in majority of patients with Parkinson's disease (PD). Mucuna pruriens, a legume extensively used in Ayurveda to treat PD, is reputed to provide anti-parkinsonian benefits without inducing DID. We compared the behavioral effects of chronic parenteral administration of a water extract of M. pruriens seed powder (MPE) alone without any additives, MPE combined with the peripheral dopa-decarboxylase inhibitor (DDCI) benserazide (MPE+BZ), LD+BZ and LD alone without BZ in the hemiparkinsonian rat model of PD. A battery of behavioral tests assessed by blinded investigators served as outcome measures in these randomized trials. In experiment 1, animals that received LD+BZ or MPE+BZ at high (6mg/kg) and medium (4mg/kg) equivalent doses demonstrated significant alleviation of parkinsonism, but, developed severe dose-dependent DID. LD+BZ at low doses (2mg/kg) did not provide significant alleviation of parkinsonism. In contrast, MPE+BZ at an equivalent low dose significantly ameliorated parkinsonism. In experiment 2, MPE without any additives (12mg/kg and 20mg/kg LD equivalent dose) alleviated parkinsonism with significantly less DID compared to LD+BZ or MPE+BZ. In experiment 3, MPE without additives administered chronically provided long-term anti-parkinsonian benefits without causing DID. In experiment 4, MPE alone provided significantly more behavioral benefit when compared to the equivalent dose of synthetic LD alone without BZ. In experiment 5, MPE alone reduced the severity of DID in animals initially primed with LD+BZ. These findings suggest that M. pruriens contains water-soluble ingredients that either have an intrinsic DDCI-like activity or mitigate the need for an add-on DDCI to ameliorate parkinsonism. These unique long-term anti-parkinsonian effects of a parenterally administered water extract of M. pruriens seed powder may provide a platform for future drug

  5. MONA, LISA and VINCI Soon Ready to Travel to Paranal

    Science.gov (United States)

    2000-11-01

    Spatiale (DESPA) of the Paris Observatory. It was used in 1991 at the Kitt Peak National Observatory (Arizona, USA), for the first (coherent) combination of the light beams from two independent telescopes by means of optical fibers of fluoride glass. It has since been in operation for five years as a focal instrument at the IOTA Interferometer (Mount Hopkins, Arizona, USA) within a collaboration with the Harvard Smithsonian Center for Astrophysics), producing a rich harvest of scientific data. The VINCI partners The VINCI instrument is constructed in a collaboration between ESO (that also finances it) and the following laboratories and institutes: * DESPA (Paris Observatory) provides the expertise, the general concept, the development and integration of the optomechanics (with the exception of the camera) and the electronics, * Observatoire Midi-Pyrénées that produces the control software * The LISA infrared camera is developed by the Max-Planck-Institut für Extraterrestrische Physik (Garching, Germany), and * ESO provides the IR camera electronics and the overall observational software and is also responsible for the final integration. DESPA delivered VINCI to ESO in Garching on September 27, 2000, and is now assembling the instrument in the ESO optical workshop. It will stay here during three months, until it has been fully integrated and thoroughly tested. It will then be shipped to Paranal at the beginning of next year. After set-up and further tests, the first observations on the sky are expected in late March 2001. Fluoride fibers guide the light The heart of VINCI - named MONA - is a fiber optics beam combine unit. It is the outcome of a fertile, 10-year research partnership between Science (DESPA) and Industry ("Le Verre Fluoré" [2]). Optical fibers will be used to combine the light from two telescopes inside VINCI . Since the instrument will be working in the near-infrared region of the spectrum (wavelength 2-2.5 µm), it is necessary to use optical fibers

  6. Planet Formation in Action? - Astronomers may have found the first object clearing its path in the natal disc surrounding a young star

    Science.gov (United States)

    2011-02-01

    , astronomers can remove most of the blurring effect of the atmosphere and obtain very sharp images. The team used NACO in a novel way, called sparse aperture masking (SAM) to search for the companion. This is a type of interferometry that, rather than combining the light from multiple telescopes as the VLTI does, uses different parts of the mirror of a single telescope (in this case, the mirror of the VLT Unit Telescope 4). This new technique is particularly good for finding faint objects very close to bright ones. VLTI/AMBER is better suited to studying the structure of the inner disc and is less sensitive to the presence of a distant companion. [5] The astronomers searched for the companion using NACO in two different spectral bands - at around 2.2 microns and at 3.8 microns. The companion is only seen at the longer wavelength, which means that the object is either cool, like a planet, or a dust-shrouded brown dwarf. [6] Brown dwarfs are objects between stars and planets in size. They are not massive enough to fuse hydrogen in their cores but are larger than giant planets such as Jupiter. More information This research was presented in two papers: Olofsson et al. 2011, "Warm dust resolved in the cold disk around TCha with VLTI/AMBER", and Huélamo et al. 2011, "A companion candidate in the gap of the T Cha transitional disk", to appear in the journal Astronomy & Astrophysics. The team is composed of J. Olofsson (Max-Planck-Institut für Astronomie [MPIA], Heidelberg, Germany), M. Benisty (MPIA), J.-C. Augereau (Institut de Planétologie et d'Astrophysique de Grenoble [IPAG], France) C. Pinte (IPAG), F. Ménard (IPAG), E. Tatulli (IPAG), J.-P. Berger (ESO, Santiago, Chile), F. Malbet (IPAG), B. Merín (Herschel Science Centre, Madrid, Spain), E. F. van Dishoeck (Leiden University, Holland), S. Lacour (Observatoire de Paris, France), K. M. Pontoppidan (California Institute of Technology, USA), J.-L. Monin (IPAG), J. M. Brown (Max-Planck-Institut für extraterrestrische Physik

  7. Pleural fluid cell-free DNA integrity index to identify cytologically negative malignant pleural effusions including mesotheliomas

    International Nuclear Information System (INIS)

    Sriram, Krishna B; Courtney, Deborah; Yang, Ian A; Bowman, Rayleen V; Fong, Kwun M; Relan, Vandana; Clarke, Belinda E; Duhig, Edwina E; Windsor, Morgan N; Matar, Kevin S; Naidoo, Rishendran; Passmore, Linda; McCaul, Elizabeth

    2012-01-01

    The diagnosis of malignant pleural effusions (MPE) is often clinically challenging, especially if the cytology is negative for malignancy. DNA integrity index has been reported to be a marker of malignancy. The aim of this study was to evaluate the utility of pleural fluid DNA integrity index in the diagnosis of MPE. We studied 75 pleural fluid and matched serum samples from consecutive subjects. Pleural fluid and serum ALU DNA repeats [115bp, 247bp and 247bp/115bp ratio (DNA integrity index)] were assessed by real-time quantitative PCR. Pleural fluid and serum mesothelin levels were quantified using ELISA. Based on clinico-pathological evaluation, 52 subjects had MPE (including 16 mesotheliomas) and 23 had benign effusions. Pleural fluid DNA integrity index was higher in MPE compared with benign effusions (1.2 vs. 0.8; p<0.001). Cytology had a sensitivity of 55% in diagnosing MPE. If cytology and pleural fluid DNA integrity index were considered together, they exhibited 81% sensitivity and 87% specificity in distinguishing benign and malignant effusions. In cytology-negative pleural effusions (35 MPE and 28 benign effusions), elevated pleural fluid DNA integrity index had an 81% positive predictive value in detecting MPEs. In the detection of mesothelioma, at a specificity of 90%, pleural fluid DNA integrity index had similar sensitivity to pleural fluid and serum mesothelin (75% each respectively). Pleural fluid DNA integrity index is a promising diagnostic biomarker for identification of MPEs, including mesothelioma. This biomarker may be particularly useful in cases of MPE where pleural aspirate cytology is negative, and could guide the decision to undertake more invasive definitive testing. A prospective validation study is being undertaken to validate our findings and test the clinical utility of this biomarker for altering clinical practice

  8. In-medium properties of hadrons – Recent experimental results and ...

    Indian Academy of Sciences (India)

    Germany. E-mail: Volker.Metag@exp2.physik.uni-giessen.de. Abstract. .... but the experiment integrates over the complex space–time history of the reaction ..... This is illustrated in figure 10 which shows the result of a calculation within the.

  9. Physical Properties Data for Rock Salt

    Science.gov (United States)

    1981-01-01

    stress MPa. CPa___ 1111 Sanchez. C.. Lioma. 1.S., Jargiu, F.. and Agullo-Lopez. F.. I Time man , h, "Influence of the Aggregation State of Ca2+ Ions...112 Eukn .. tbrdeTmea uahniki e reet 1331 Somerton . W.H. sand Boozer, G.D.. "T1hermal Characteristics of fahigkeit fester Nichimetalle." Ann. Physik

  10. Computer codes KASCO and KARDIF for processing cross-sections data; Computerprogramme zur Bearbeitung der Wirkungsquerschnitts-Dateien KASCO und KARDIF

    Energy Technology Data Exchange (ETDEWEB)

    Muenzel, H; Neumann, B; Klewe-Nebenius, H; Pfennig, G

    1981-12-01

    Document of internal interest, not to be sent out without permission of authors. Summary of the computer program developed at the Karlsruhe Charged Group (Kachapag) for producing from EXFOR the handbook series `Physik Daten/Physics Data Nr. 15` of the Fachinformationszentrum Karlsruhe. (author) 6 figs. The full text is available from IAEA Nuclear Data Section

  11. Vector mesons in strongly interacting matter

    Indian Academy of Sciences (India)

    E-mail: volker.metag@exp2.physik.uni-giessen.de. Abstract. .... constraints on hadronic spectral functions but cannot predict their detailed shape. Hadronic ..... nuclear medium, despite a cut on low momentum ω-mesons: pω ≤ 500 MeV/c. A.

  12. Computer codes KASCO and KARDIF for processing cross-sections data

    International Nuclear Information System (INIS)

    Muenzel, H.; Neumann, B.; Klewe-Nebenius, H.; Pfennig, G.

    1981-01-01

    Document of internal interest, not to be sent out without permission of authors. Summary of the computer program developed at the Karlsruhe Charged Group (Kachapag) for producing from EXFOR the handbook series 'Physik Daten/Physics Data Nr. 15' of the Fachinformationszentrum Karlsruhe. (author)

  13. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Max-Planck-Institut f ur Physik, Munich, Germany; Joint Institute for Nuclear Research, Dubna, Russia; Rudjer Boskovic Institute, Zagreb, Croatia; KFKI Research Institute for Particle and Nuclear Physics, Budapest, Hungary; Institute of Nuclear Physics, Cracow, Poland; Birmingham University, Birmingham, England ...

  14. A new observable to measure the top quark mass at hadron colliders

    Indian Academy of Sciences (India)

    Ernest Orlando Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA; DESY, Platanenallee 6, 15738 Zeuthen, Germany; IFIC, Centre Mixte CSIC-Universitat de València, E-46071 València, Spain; Institut für Physik, Humboldt-Universität zu Berlin, Newtonstr. 15, 12489 Berlin, Germany ...

  15. Teilchen, Felder, Quanten von der Quantenmechanik zum Standardmodell der Teilchenphysik

    CERN Document Server

    Ecker, Gerhard

    2017-01-01

    Dieses Buch bietet Ihnen eine Einführung in den aktuellen Stand unseres Wissens über die Struktur der Materie. Gerhard Ecker beschreibt verständlich die Entwicklung der modernen Physik vom Beginn des Quantenzeital­ters bis zum Standardmodell der Teilchenphysik, der umfassenden Theorie der fundamentalen Wechselwir­kungen des Mikrokosmos. Dabei wird der Schwerpunkt auf die wichtigsten Entdeckungen und Entwicklungen, beispielsweise der Quantenfeldtheorie, der Eichtheorien und die Zukunft der Teilchenphysik, gelegt. Besonders hebt der Autor auch das Wechselspiel zwischen Theorie und Experiment hervor, die uns helfen, die tiefsten Rätsel der Natur zu ergründen. Teilchen, Felder, Quanten ist für alle geschrieben, die Freude an der Physik haben. Es bietet Abitu­rienten und Studierenden der Physik in den ersten Semestern einen Ansporn, die Physik tiefer zu verstehen. Lehrer und andere an der Phy­sik Interessierte werden darin nützliche Einblicke in die Welt der Teilchenphysik finden. Für Studierende in ...

  16. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    ... India; Division of Physics, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan; Advanced Science Research Center, Japan Atomic Energy Research Institute, Tokai, Ibaraki 319-11, Japan; Institut für Theoretische Physik, Johann Wolfgang Goethe-Universität, Robert-Mayer-Str. 10, 60325 Frankfurt ...

  17. Untitled

    Indian Academy of Sciences (India)

    Smith and Carson ... Z. Physikal. Chenn., 1908, 6, 200. 13. Ephraim ... Z. anord. Chen., 190S, 58, 33S. 14. Wright ... J. Chen. Soc, 1915, 107, 1527. 15. Amadori ... Gazetta, 1922, 1, 52, 387. 16. Mori ... J. Chen. Soc., Japa), 1923, 44, 730. 17. Waradachari and Subra- Proc. Ind. Acad, Sci., 1936, 3 A, 428. Ilala. 18. Hervey and ...

  18. The Special Theory of Relativity

    Indian Academy of Sciences (India)

    cial theory of relativity were published in the journal. Annalen der Physik, and were titled 'On the electro- dynamics of ... Historical Background. In order to set Einstein's work in proper perspective, re- call that, in ... ideas of absolute space and time firmly entrenched, most physicists thought that this speed was correct only in.

  19. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    We review some recent studies about the parameter determination of top quarks, bosons, Higgs bosons, supersymmetric particles and in the ADD model of extra dimensions at a linear collider. Author Affiliations. Alfred Bartl1 Stefan Hesselbach1. Institut für Theoretische Physik, Universität Wien, Boltzmanngasse 5, ...

  20. Bibliography of Soviet Laser Developments, Number 88, March - April 1987.

    Science.gov (United States)

    1988-03-03

    der Physik (Leipzig) ATPLB Acta physica polonica . Series A AVMEB Avtometriya (CTC) BIPED Buletinul Institutului politehnic Gheorghe Gheorghiu-Dej...Problemy fonovogo monitoringa sostoyaniya prirodnoy sredy (abornik, Leningrad) PRTEA Pribory i tekhnika eksperimenta (CTC) PSSAB Physica status solidi (A...Applied Research (GDR) PSSBB Physica status solidi (B). Basic Research (GDR) PZTFD Zhurnal tekhnicheskoy fiziki. Pis’ma (CTC) RAELA Radiotekhnika i

  1. Bibliography of Soviet Laser Developments, Number 87, January-February 1987

    Science.gov (United States)

    1987-12-29

    Physik (Leipzig) ATPLB Acta physica polonica . Series A AVMEB Avtometriya (CTC) CRABA Bolgarskaya akademiya nauk. Dokiady (formerly: Bulgarska... Physica status solidi (A). Applied Research (GDR) PSSBB Physica status solidi (B). Basic Research (GDR) PZTFD Zhurnal tekhnicheskoy fiziki. Pis’ma (CTC

  2. On the quantization of wave fields⋆

    Science.gov (United States)

    Rosenfeld, L.

    2017-04-01

    Originally published in German "Zur Quantelung der Wellenfelder" in Annalen der Physik 397, 113 (1930). Submitted for publication on March 18, 1930Translated by Donald Salisbury, Max-Planck-Institut für Wissenschaftsgeschichte, Berlin and Austin College, Sherman, TX, USA and Kurt Sundermeyer, Max-Planck-Institut für Wissenschaftsgeschichte, Berlin. DSalisbury@austincollege.edu

  3. Medical physics, 1984

    International Nuclear Information System (INIS)

    Schmidt, T.

    1985-01-01

    The papers presented at the 15th Scientific Conference of the Deutsche Gesellschaft fuer Medizinische Physik, held from September 27-28, 1984 in Nuernberg, F.R.G., give an account of the advances made with regard to quality control and management and to radiological safety problems and requirements in the fields of radiological and nuclear medical diagnostics and radiotherapy. (WU) [de

  4. Improving Radar QPE's in Complex Terrain for Improved Flash Flood Monitoring and Prediction

    Science.gov (United States)

    Cifelli, R.; Streubel, D. P.; Reynolds, D.

    2010-12-01

    Quantitative Precipitation Estimation (QPE) is extremely challenging in regions of complex terrain due to a combination of issues related to sampling. In particular, radar beams are often blocked or scan above the liquid precipitation zone while rain gauge density is often too low to properly characterize the spatial distribution of precipitation. Due to poor radar coverage, rain gauge networks are used by the National Weather Service (NWS) River Forecast Centers as the principal source for QPE across the western U.S. The California Nevada River Forecast Center (CNRFC) uses point rainfall measurements and historical rainfall runoff relationships to derive river stage forecasts. The point measurements are interpolated to a 4 km grid using Parameter-elevation Regressions on Independent Slopes Model (PRISM) data to develop a gridded 6-hour QPE product (hereafter referred to as RFC QPE). Local forecast offices can utilize the Multi-sensor Precipitation Estimator (MPE) software to improve local QPE’s and thus local flash flood monitoring and prediction. MPE uses radar and rain gauge data to develop a combined QPE product at 1-hour intervals. The rain gauge information is used to bias correct the radar precipitation estimates so that, in situations where the rain gauge density and radar coverage are adequate, MPE can take advantage of the spatial coverage of the radar and the “ground truth” of the rain gauges to provide an accurate QPE. The MPE 1-hour QPE analysis should provide better spatial and temporal resolution for short duration hydrologic events as compared to 6-hour analyses. These hourly QPEs are then used to correct radar derived rain rates used by the Flash Flood Monitoring and Prediction (FFMP) software in forecast offices for issuance of flash flood warnings. Although widely used by forecasters across the eastern U.S., MPE is not used extensively by the NWS in the west. Part of the reason for the lack of use of MPE across the west is that there has

  5. Pleural Effusion in Multiple Myeloma.

    Science.gov (United States)

    Wang, Zhuo; Xia, Guoguang; Lan, Ling; Liu, Fayong; Wang, Yanxun; Liu, Baoyue; Ding, Yi; Dai, Li; Zhang, Yunjian

    2016-01-01

    Pleural effusion is rarely observed in patients with multiple myeloma (MM). Myeloma cell infiltration or invasion to the pleura is very rare. This study aimed to investigate the clinical characteristics of pleural effusion in patients with MM. We retrospectively reviewed the medical records of patients diagnosed with pleural effusion, MM, and pleural effusion with MM between 2004 and 2014 at Beijing Jishuitan Hospital. The present study included patients with pleural effusion who underwent cytological, bacteriological, biochemical and other testing. The cytopathology of abnormal pleural effusion cells was not diagnostic, thus flow cytometry was performed. MM was defined using the diagnosis standard of NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) 2014 for MM. This study included 3,480 pleural effusion patients and 319 MM patients. There were 34 patients with both MM and pleural effusion (17 men and 17 women). The average age was 63 years (range, 48-84 years). Pleural effusion with MM was caused by congestive heart disease, chronic renal failure, hypoalbuminemia, pulmonary infarctions, cirrhosis, pulmonary arterial hypertension, parapneumonic effusion, tuberculous pleural effusion, and myelomatous pleural effusion (MPE). The diagnosis of MPE was confirmed by the detection of myeloma cells in the pleural fluid using flow cytometric analyses. There were only 2 MPE cases in our study. The first MPE case was a woman. The first clinical manifestation was pleural effusion, and the diagnosis was non-secretory MM, DSS stage IIIA (Durie-Salmon staging system); ISS stage I (the International Staging System). The second MPE case was a man who was diagnosed with MM IgA-κ, DSS stage IIIA; ISS stage II. The detection rate of MPE was very low. MPE tended to present with yellow exudates and the lack of physical and chemical characteristics. Furthermore, patients with MPE exhibited many yellow nodules on the pleura. These nodules were lobulated and had abundant

  6. Enzyme-catalyzed hydrolysis of dentin adhesives containing a new urethane-based trimethacrylate monomer

    Science.gov (United States)

    Park, Jong-Gu; Ye, Qiang; Topp, Elizabeth M.; Spencer, Paulette

    2009-01-01

    A new trimethacrylate monomer with urethane-linked groups, 1,1,1-tri-[4-(methacryloxyethylamino-carbonyloxy)-phenyl]ethane (MPE), was synthesized, characterized, and used as a co-monomer in dentin adhesives. Dentin adhesives containing 2-hydroxyethyl methacrylate (HEMA, 45% w/w) and 2,2-bis[4(2-hydroxy-3-methacryloyloxy-propyloxy)-phenyl] propane (BisGMA, 30% w/w) in addition to MPE (25% w/w) were formulated with H2O at 0 (MPE0), 8 (MPE8) and 16 wt % water (MPE16) to simulate the wet demineralized dentin matrix and compared with controls [HEMA/BisGMA, 45/55 w/w, at 0 (C0), 8 (C8) and 16 wt% water (C16)]. The new adhesive showed a degree of double bond conversion and mechanical properties comparable with control, with good penetration into the dentin surface and a uniform adhesive/dentin interface. On exposure to porcine liver esterase, the net cumulative methacrylic acid (MAA) release from the new adhesives was dramatically (P < 0.05) decreased relative to the control, suggesting that the new monomer improves esterase resistance. PMID:19582843

  7. Prophylactic effect of Mucuna pruriens Linn (velvet bean) seed extract against experimental Naja sputatrix envenomation: gene expression studies.

    Science.gov (United States)

    Fung, Shin Yee; Sim, Si Mui; Kandiah; Jeyaseelan; Armugam, Arunmozhiarasi; Aguiyi, John Chinyere; Tan, Nget Hong

    2014-09-01

    Mucuna pruriens is widely used in traditional medicine for treatments of various diseases. In certain region of Nigeria, the seed is used as oral prophylactics for snakebite. Rats pretreated with the aqueous extract from M. pruriens seed (MPE) were protected against the lethal effects of Naja sputatrix (Javan spitting cobra) venom [Tan et al., J Ethnopharmacol, 123 (2009) 356]. The pretreatment also protected against venom-induced histopathological changes in rat heart. To contribute to the understanding of the mechanism of cardio-protective action, the present study examined the effects of MPE-pretreatment on gene expression profile of rat heart as well as effect of MPE-pretreatment on N. sputatrix venom-induced gene expression alterations in rat heart. The gene expression profiles were examined by microarray analysis and verified by real time PCR. The results showed that pretreatment with MPE caused 50 genes in the rat heart substantially up-regulated of which 19 were related to immune responses, 7 were related to energy production and metabolism. The up-regulation of genes related to energy metabolism probably plays a role in maintaining the viability of the heart. Four other genes that were up-regulated (alpha synuclein, natriuretic peptide precursor, calsequestrin and triadin) were involved in the maintenance of homeostasis of the heart or maintaining its viability, thereby contributing to the direct protective action. The results demonstrated that protective effect of MPE pretreatment against snake venom poisoning may involve a direct action on the heart.

  8. The efficacy of Jackson drain in the application to be a tunnel pleural catheter (TPC) in the management of malignant pleural effusion.

    Science.gov (United States)

    Tscheikuna, Jamsak; Thomrongpairoj, Preecha; Disayabutr, Suppareurg

    2011-06-01

    Malignant pleural effusion (MPE) is a common clinical problem in patients with advanced cancer and portends a poor prognosis, which means survival of less than six months. In June 1997, the US-FDA approved an indwelling TPC with a one-way drainage valve to be used in the management of MPE. Although popularity of this TPC has increased over the past few years, the experience with this device remains limited in Thai patients. One of the reasons is its high cost. Assess the efficacy and the safety of customary indwelling TPC by using Jackson drain in the management of patients with symptomatic MPE. Ten patients with symptomatic MPE were receiving these catheters (18 Fr Silicone catheters with 25 cm fenestrated length) to drain effusion via plastic vacuum bottles (250 ml) every other day or as needed to relieve dyspnea. The patient's dyspnic respiration, quality of life, and comfort during the catheter's application were quantified with a Borg score, the St. George Respiratory Disease Questionnaire (SGRQ), and the comfort's score, respectively. These parameters were recorded at initial (before insertion) and 2-week follow-up visit. Pain after 24 hours of each insertion was quantified by visual pain analogue scale (VPAS). Patients were followed until either death or catheter removal. The Borg score, SGRQ, and comfort's score showed significant improvement at 2-week visit (p drain was effective in the treatment of MPE as a TPC without early complications.

  9. Application of Fungicides and Microalgal Phenolic Extracts for the Direct Control of Fumonisin Contamination in Maize.

    Science.gov (United States)

    Scaglioni, Priscila Tessmer; Blandino, Massimo; Scarpino, Valentina; Giordano, Debora; Testa, Giulio; Badiale-Furlong, Eliana

    2018-05-16

    Fungicides and, for the first time, microalgal phenolic extracts (MPE) from Spirulina sp. and Nannochloropsis sp. were applied on maize culture media under field conditions to evaluate their ability to minimize Fusarium species development and fumonisin production. An in vitro assay against F. verticillioides was carried out using maize grains as the culture medium. An open-field experiment was carried out in Northwest Italy under natural infection conditions. The compared treatments were factorial combinations of two insecticide treatments (an untreated control and pyrethroid, used against European Corn Borer), four antifungal treatments (an untreated control, MPE from Spirulina sp., MPE from Nannochloropsis sp., and a synthetic fungicide), and two timings of the application of the antifungal compounds (at maize flowering and at the milk stage). The MPE compounds were capable of inhibiting fumonisin production in vitro more efficiently than tebuconazole. Insecticide application reduced the infection by Fusarium species and subsequent fumonisin contamination. However, fumonisins in maize fields were not significantly controlled by either fungicide or MPE application.

  10. Potential effect of Olea europea leaves, Sonchus oleraceus leaves and Mangifera indica peel extracts on aromatase activity in human placental microsomes and CYP19A1 expression in MCF-7 cell line: Comparative study.

    Science.gov (United States)

    Shaban, N Z; Hegazy, W A; Abdel-Rahman, S M; Awed, O M; Khalil, S A

    2016-08-29

    Aromatase inhibitors (AIs) provide novel approaches to the adjuvant therapy for postmenopausal women with estrogen-receptor-positive (ER+) breast cancers. In this study, different plant extracts from Olea europaea leaves (OLE), Sonchus oleraceus L. (SOE) and Mangifera indica peels (MPE) were prepared to identify phytoconstituents and measure antioxidant capacities. The effects of these three extracts on aromatase activity in human placental microsomes were evaluated. Additionally, the effects of these extracts on tissue-specific promoter expression of CYP19A1 gene in cell culture model (MCF-7) were assessed using qRT-PCR. Results showed a concentration-dependent decrease in aromatase activity after treatment with OLE and MPE, whereas, SOE showed a biphasic effect. The differential effects of OLE, SOE and MPE on aromatase expression showed that OLE seems to be the most potent suppressor followed by SOE and then MPE. These findings indicate that OLE has effective inhibitory action on aromatase at both the enzymatic and expression levels, in addition to its cytotoxic effect against MCF-7 cells. Also, MPE may be has the potential to be used as a tissue-specific aromatase inhibitor (selective aromatase inhibitor) and it may be promising to develop a new therapeutic agent against ER+ breast cancer.

  11. Diagnostic value of medical thoracoscopy in malignant pleural effusion induced by non-Hodgkin's lymphoma.

    Science.gov (United States)

    Wang, Zhen; Wu, Yan-Bing; Xu, Li-Li; Jin, Mu-Lan; Diao, Xiao-Li; Wang, Xiao-Juan; Tong, Zhao-Hui; Shi, Huan-Zhong

    2017-12-01

    Malignant pleural effusion (MPE) appears in up to 20% of patients with non-Hodgkin's lymphoma (NHL). The present study aimed to assess the efficacy of medical thoracoscopy (MT) in the diagnosis of patients with MPE induced by NHL. Between July 2005 and June 2014, 833 patients with pleural effusions of unknown etiology underwent MT in Beijing Chaoyang Hospital (Beijing, China), where diagnostic thoracocentesis or/and blind pleural biopsy had failed to yield an answer. Demographic, radiographic, thoracoscopic, histological and immunophenotyping data of 10 NHL patients with MPE were then retrospectively analyzed. Under medical thoracoscopy, pleural nodules (in n=6 patients), hyperemia (n=5), plaque-like lesions (n=4), pleural thickening (n=3), cellulose (n=3), ulcer (n=2), adhesion (n=2), and scattered hemorrhagic spots (n=1) were observed on the surface of parietal pleura. Histopathological and immunohistochemical analysis of pleural biopsy samples led to a correct diagnosis of B-cell NHL in 7 patients and T-lymphoblastic NHL in 2 patients. Data from the present study demonstrated that pleural biopsy through MT achieved a definite diagnosis of NHL in 9 out of 10 (90%) patients with MPE induced by NHL. Therefore, MT is a useful method for diagnosing MPE induced by NHL.

  12. Rudolf Mössbauer in Munich

    Science.gov (United States)

    Kalvius, G. M.; Kienle, P.

    Mössbauer and one of the authors (PK) started in 1949 studying physics at the Technische Hochschule München (THM), which was still under reconstruction from the war damages. It offered two directions for studying physics: "Physik A" and "Physik B." I took courses in "Physik A," which meant Technical Physics; Mössbauer studied "Physik B," which was General Physics. Actually, the lectures of both directions were not too different up to the forth semester, followed by a "pre-diploma" examination, which Mössbauer passed in 1952. I as "Physik A" student had besides the various physics, chemistry, and mathematics courses, in addition lectures in Technical Electricity, Technical Mechanics, Technical Thermodynamics, and later Measurement Engineering offered by very famous professors, such as W.O. Schumann, L. Föppl, W. Nußelt, and H. Piloty. Our physics teachers were G. Joos (Experimental physics), G. Hettner (Theoretical Physics), and W. Meissner (Technical Physics); in mathematics, we enjoyed lectures by J. Lense and R. Sauer, and interesting chemistry lectures by W. Hieber. Thus we received a high-class classical education, but quantum mechanics was not a compulsory subject. Mössbauer complained about this deficiency when he realized that the effect he found was a quantum mechanical phenomenon. Quantum mechanics was offered as an optional subject by Prof. Fick and Prof. Haug. Mössbauer just missed to take these advanced lectures, although he was highly talented in mathematics and received even a tutoring position in the mathematics institute of Prof. R. Sauer, while I worked in engineering projects and had extensive industrial training.

  13. The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra (Naja sputatrix) venom in rats.

    Science.gov (United States)

    Fung, S Y; Tan, N H; Liew, S H; Sim, S M; Aguiyi, J C

    2009-04-01

    Seed of Mucuna pruriens (Velvet beans) has been prescribed by traditional medicine practitioners in Nigeria as a prophylactic oral antisnake remedy. In the present studies, we investigated the protective effects of M. pruriens seed extract (MPE) against histopathological changes induced by intravenous injection of Naja sputatrix (Malayan cobra) venom in rats pretreated with the seed extract. Examination by light microscope revealed that the venom induced histopathological changes in heart and blood vessels in liver, but no effect on brain, lung, kidney and spleen. The induced changes were prevented by pretreatment of the rats with MPE. Our results suggest that MPE pretreatment protects rat heart and liver blood vessels against cobra venom-induced damages.

  14. Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats.

    Science.gov (United States)

    Fung, S Y; Tan, N H; Sim, S M

    2010-12-01

    The protective effects of Mucuna pruriens seed extract (MPE) against the cardio-respiratory depressant and neuromuscular paralytic effects induced by injection of Calloselasma rhodostoma (Malayan pit viper) venom in anaesthetized rats were investigated. While MPE pretreatment did not reverse the inhibitory effect of the venom on the gastrocnemius muscle excitability, it significantly attenuated the venom-induced cardio-respiratory depressant effects (p < 0.05). The protection effects may have an immunological mechanism, as indicated by the presence of several proteins in the venom that are immunoreactive against anti-MPE. However, we cannot rule out the possibility that the pretreatment may exert a direct, non-immunological protective action against the venom.

  15. El arrendamiento financiero y valuación de opciones reales

    Directory of Open Access Journals (Sweden)

    Gastón Silverio Milanesi

    2016-01-01

    Full Text Available El trabajo estudia diferentes opciones reales simples y compuestas contenidas en los contratos de leasing, bajo una metodología que combina el método de préstamo equivalente (MPE y opciones reales. Primero se presenta formalmente el MPE y el modelo binomial para valorar las opciones del contrato. Seguida- mente se analiza el valor al vencimiento de las opciones del leasing clasificadas en: a simple: de compra, de cancelar anticipadamente, de renovación y excluyente de renovación-compra, y b compuesta: a riesgo (venture ; canon atado a intensidad de uso (percentage y de pago diferido. Utilizando diferentes casos son valuadas las opciones combinando el modelo binomial y el MPE, estimando valor expandido y valor el valor de la opción sobre el valor. Finalmente se presentan las principales conclusiones.

  16. Synthesis and characterization of biosheet impregnated with Macrotyloma uniflorum extract for burn/wound dressings.

    Science.gov (United States)

    Muthukumar, Thangavelu; Senthil, Rethinam; Sastry, Thotapalli Parvathaleswara

    2013-02-01

    Developing biomaterials having wound healing properties within the search of a common man is the need of hour, particularly in developing and third world countries. Keeping this objective in view we have developed a wound dressing material, in sheet form, containing fish scale collagen (FSC) and physiologically clotted fibrin (PCF), both are by products of aqua food and meat industries respectively. To impart antimicrobial properties to the composite sheet, it was incorporated with Macrotyloma uniflorum plant extract (MPE). SEM pictures have shown that FSC:PCF:MPE composite has fibrous and porous surface which helps in transportation of oxygen as well as absorbing wound fluids and their evaporation. The biomaterials have shown 100% biocompatibility and the percentage cell viability was found to be above 89%. The FSC:PCF:MPE biocomposite film with required mechanical strength, biocompatibility and antimicrobial properties can be tried as a burn/wound dressing material. Copyright © 2012 Elsevier B.V. All rights reserved.

  17. Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease.

    Science.gov (United States)

    Ogino, Shuji; Lochhead, Paul; Chan, Andrew T; Nishihara, Reiko; Cho, Eunyoung; Wolpin, Brian M; Meyerhardt, Jeffrey A; Meissner, Alexander; Schernhammer, Eva S; Fuchs, Charles S; Giovannucci, Edward

    2013-04-01

    Epigenetics acts as an interface between environmental/exogenous factors, cellular responses, and pathological processes. Aberrant epigenetic signatures are a hallmark of complex multifactorial diseases (including neoplasms and malignancies such as leukemias, lymphomas, sarcomas, and breast, lung, prostate, liver, and colorectal cancers). Epigenetic signatures (DNA methylation, mRNA and microRNA expression, etc) may serve as biomarkers for risk stratification, early detection, and disease classification, as well as targets for therapy and chemoprevention. In particular, DNA methylation assays are widely applied to formalin-fixed, paraffin-embedded archival tissue specimens as clinical pathology tests. To better understand the interplay between etiological factors, cellular molecular characteristics, and disease evolution, the field of 'molecular pathological epidemiology (MPE)' has emerged as an interdisciplinary integration of 'molecular pathology' and 'epidemiology'. In contrast to traditional epidemiological research including genome-wide association studies (GWAS), MPE is founded on the unique disease principle, that is, each disease process results from unique profiles of exposomes, epigenomes, transcriptomes, proteomes, metabolomes, microbiomes, and interactomes in relation to the macroenvironment and tissue microenvironment. MPE may represent a logical evolution of GWAS, termed 'GWAS-MPE approach'. Although epigenome-wide association study attracts increasing attention, currently, it has a fundamental problem in that each cell within one individual has a unique, time-varying epigenome. Having a similar conceptual framework to systems biology, the holistic MPE approach enables us to link potential etiological factors to specific molecular pathology, and gain novel pathogenic insights on causality. The widespread application of epigenome (eg, methylome) analyses will enhance our understanding of disease heterogeneity, epigenotypes (CpG island methylator

  18. Protective effect of Mimosa pudica L. in an L-arginine model of acute necrotising pancreatitis in rats.

    Science.gov (United States)

    Kaur, Jagdeep; Sidhu, Shabir; Chopra, Kanwaljit; Khan, M U

    2016-07-01

    Mimosa pudica is used in traditional medicine for treating various disorders such as inflammatory conditions, diarrhoea, insomnia, alopecia, urogenital infections and wounds. The present study investigated the effect of M. pudica extract (MPE) on L-arginine-induced acute necrotising pancreatitis in rats. The ethanolic extract of M. pudica leaves was studied for the presence of quercetin and gallic acid using high-performance liquid chromatography. Four groups were employed-normal control rats, L-arginine control rats (two intraperitoneal [i.p.] injections of 2 g/kg at an interval of 1 h), MPE-treated rats (400 mg/kg orally) and melatonin-treated rats (positive control 10 mg/kg i.p.), which were further divided into subgroups according to time points (24 h, 3 days and 14 days). Serum amylase, lipase, tumour necrosis factor-α (TNF-α), pancreatic amylase, nucleic acid content, protein, transforming growth factor-β1 (TGF-β1), thiobarbituric reactive substances, glutathione, nitrite/nitrate, collagen content and histopathological examination were carried out. MPE significantly improved acute necrotising pancreatitis by modulating diagnostic markers of pancreatitis such as serum lipase and pancreatic amylase, inflammation (TNF-α), and oxidative and nitrosative stress. Moreover, MPE administration induced regenerative changes in the pancreas evidenced by increased levels of pancreatic proteins, nucleic acid content and histopathology report. In addition, MPE improved TGF-β1 and collagen levels thereby preventing fibrosis. The current investigation indicates the novel role of MPE in reducing the severity of acute necrotising pancreatitis by plausible mechanisms such as anti-inflammatory and anti-fibrotic activity and by promoting repair and regeneration of the pancreas.

  19. Review Article: The Role of Molecular Pathological Epidemiology in the Study of Neoplastic and Non-neoplastic Diseases in the Era of Precision Medicine.

    Science.gov (United States)

    Ogino, Shuji; Nishihara, Reiko; VanderWeele, Tyler J; Wang, Molin; Nishi, Akihiro; Lochhead, Paul; Qian, Zhi Rong; Zhang, Xuehong; Wu, Kana; Nan, Hongmei; Yoshida, Kazuki; Milner, Danny A; Chan, Andrew T; Field, Alison E; Camargo, Carlos A; Williams, Michelle A; Giovannucci, Edward L

    2016-07-01

    Molecular pathology diagnostics to subclassify diseases based on pathogenesis are increasingly common in clinical translational medicine. Molecular pathological epidemiology (MPE) is an integrative transdisciplinary science based on the unique disease principle and the disease continuum theory. While it has been most commonly applied to research on breast, lung, and colorectal cancers, MPE can investigate etiologic heterogeneity in non-neoplastic diseases, such as cardiovascular diseases, obesity, diabetes mellitus, drug toxicity, and immunity-related and infectious diseases. This science can enhance causal inference by linking putative etiologic factors to specific molecular biomarkers as outcomes. Technological advances increasingly enable analyses of various -omics, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, metagenomics, microbiome, immunomics, interactomics, etc. Challenges in MPE include sample size limitations (depending on availability of biospecimens or biomedical/radiological imaging), need for rigorous validation of molecular assays and study findings, and paucities of interdisciplinary experts, education programs, international forums, and standardized guidelines. To address these challenges, there are ongoing efforts such as multidisciplinary consortium pooling projects, the International Molecular Pathological Epidemiology Meeting Series, and the Strengthening the Reporting of Observational Studies in Epidemiology-MPE guideline project. Efforts should be made to build biorepository and biobank networks, and worldwide population-based MPE databases. These activities match with the purposes of the Big Data to Knowledge (BD2K), Genetic Associations and Mechanisms in Oncology (GAME-ON), and Precision Medicine Initiatives of the United States National Institute of Health. Given advances in biotechnology, bioinformatics, and computational/systems biology, there are wide open opportunities in MPE to contribute to public

  20. Østersølaks bedst til at afvise snyltere

    DEFF Research Database (Denmark)

    Buchmann, Kurt

    2006-01-01

    Danske forskere fra KVL har påvist at østersølaks er langt bedre end skotske laks til at bekæmpe de patogene parasitter ved navn Gyrodactylus salaris. Laks fra Skotland og Norge reagerer uhen sigtmæssigt, medens østersølaksen producerer relevante immunfaktorer.......Danske forskere fra KVL har påvist at østersølaks er langt bedre end skotske laks til at bekæmpe de patogene parasitter ved navn Gyrodactylus salaris. Laks fra Skotland og Norge reagerer uhen sigtmæssigt, medens østersølaksen producerer relevante immunfaktorer....

  1. Kinas nye mand vil korruptionen til livs

    DEFF Research Database (Denmark)

    Høyrup Christensen, Nis

    2013-01-01

    Kampen mod korruption er det første konkrete programpunkt, som Kinas nye mand i spidsen, Xi Jinping, har meldt ud. Dermed sender han et klart signal til de 80 millioner medlemmer i partiet og til den kæmpe administration, han er øverste chef for: Der skal handling til.......Kampen mod korruption er det første konkrete programpunkt, som Kinas nye mand i spidsen, Xi Jinping, har meldt ud. Dermed sender han et klart signal til de 80 millioner medlemmer i partiet og til den kæmpe administration, han er øverste chef for: Der skal handling til....

  2. Extrasolar Giant Planet in Earth-like Orbit

    Science.gov (United States)

    1999-07-01

    Discovery from a Long-term Project at La Silla A new extrasolar planet has been found at the ESO La Silla Observatory as a companion to iota Horologii (iota Hor) . This 5.4-mag solar-type star is located at a distance of 56 light-years and is just visible to the unaided eye in the southern constellation Horologium (The Pendulum Clock). The discovery is the result of a long-term survey of forty solar-type stars that was begun in November 1992. It is based on highly accurate measurements of stellar radial velocities, i.e. the speed with which a star moves along the line of sight. The presence of a planet in orbit around a star is inferred from observed, regular changes of this velocity, as the host star and its planet revolve around a common center of gravity. Since in all cases the star is much heavier than the planet, the resulting velocity variations of the star are always quite small. The team that found the new planet, now designated iota Hor b , consists of Martin Kürster , Michael Endl and Sebastian Els (ESO-Chile), Artie P. Hatzes and William D. Cochran (University of Texas, Austin, USA), and Stefan Döbereiner and Konrad Dennerl (Max-Planck-Institut für extraterrestrische Physik, Garching, Germany). Iodine cell provides very accurate velocity measurements iota Hor b represents the first discovery of an extrasolar planet with an ESO instrument [1]. The finding is based on data obtained with ESO's highest-resolution spectrograph, the Coudé Echelle Spectrometer (CES) at the 1.4-m Coudé Auxiliary Telescope (CAT). While this telescope has recently been decommissioned, the CES instrument is now coupled via an optical fiber link to the larger ESO 3.6-m telescope, thus permitting the continuation of this survey. The high precision radial velocity measurements that are necessary for a study of this type were achieved by means of a special calibration technique. It incorporates an iodine gas absorption cell and sophisticated data modelling. The cell is used like

  3. Power Control at Grid Connected Converters and Analytical Solution of Steady States

    Czech Academy of Sciences Publication Activity Database

    Valouch, Viktor; Škramlík, Jiří; Muller, Z.; Švec, J.; Tlustý, J.

    2015-01-01

    Roč. 2015, September (2015), s. 1-12 ISSN 1024-123X Institutional support: RVO:61388998 Keywords : power control * converter * grid Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 0.644, year: 2015 http://downloads.hindawi.com/journals/mpe/2015/601916.pdf

  4. Intelligent bakteriebekæmpelse

    DEFF Research Database (Denmark)

    Givskov, Michael Christian

    2004-01-01

    En lovende metode til at bekæmpe bakterielle infektioner er populært sagt at forhindre forhindre bakterierne i at kommunikere med hinanden. Ved at hæmme bakteriernes kommunikationssystemer, kan man reducere ellers sygdomsfremkaldende bakterier til harmløse....

  5. The Magnetohydrodynamic Generator A Physics Olympiad Problem

    Indian Academy of Sciences (India)

    The Magnetohydrodynamic Generator A Physics Olympiad Problem (2001). Vijay A Singh ... Magnetohydrodynamics; generator; power; efficiency; Faraday's law; Physics Olympiad . Author Affiliations. Vijay A Singh1 Manish Kapoor2. Physics Department Indian Institute of Technology Kanpur 208016, India. MPE College ...

  6. Antioxidant capacity and radical scavenging effect of polyphenol rich Mallotus philippenensis fruit extract on human erythrocytes: an in vitro study.

    Science.gov (United States)

    Gangwar, Mayank; Gautam, Manish Kumar; Sharma, Amit Kumar; Tripathi, Yamini B; Goel, R K; Nath, Gopal

    2014-01-01

    Mallotus philippinensis is an important source of molecules with strong antioxidant activity widely used medicinal plant. Previous studies have highlighted their anticestodal, antibacterial, wound healing activities, and so forth. So, present investigation was designed to evaluate the total antioxidant activity and radical scavenging effect of 50% ethanol fruit glandular hair extract (MPE) and its role on Human Erythrocytes. MPE was tested for phytochemical test followed by its HPLC analysis. Standard antioxidant assays like DPPH, ABTS, hydroxyl, superoxide radical, nitric oxide, and lipid peroxidation assay were determined along with total phenolic and flavonoids content. Results showed that MPE contains the presence of various phytochemicals, with high total phenolic and flavonoid content. HPLC analysis showed the presence of rottlerin, a polyphenolic compound in a very rich quantity. MPE exhibits significant strong scavenging activity on DPPH and ABTS assay. Reducing power showed dose dependent increase in concentration absorption compared to standard, Quercetin. Superoxide, hydroxyl radical, lipid peroxidation, nitric oxide assay showed a comparable scavenging activity compared to its standard. Our finding further provides evidence that Mallotus fruit extract is a potential natural source of antioxidants which have a protective role on human Erythrocytes exhibiting minimum hemolytic activity and this justified its uses in folklore medicines.

  7. Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions.

    Directory of Open Access Journals (Sweden)

    Eleanor K Mishra

    Full Text Available The minimal important difference (MID is essential for interpreting the results of randomised controlled trials (RCTs. Despite a number of RCTs in patients with malignant pleural effusions (MPEs which use the visual analogue scale for dyspnea (VASD as an outcome measure, the MID has not been established.Patients with suspected MPE undergoing a pleural procedure recorded their baseline VASD and their post-procedure VASD (24 hours after the pleural drainage, and in parallel assessed their breathlessness on a 7 point Likert scale.The mean decrease in VASD in patients with a MPE reporting a 'small but just worthwhile decrease' in their dyspnea (i.e. equivalent to the MID was 19mm (95% CI 14-24mm. The mean drainage volume required to produce a change in VASD of 19mm was 760ml.The mean MID for the VASD in patients with a MPE undergoing a pleural procedure is 19mm (95% CI 14-24mm. Thus choosing an improvement of 19mm in the VASD would be justifiable in the design and analysis of future MPE studies.

  8. Above- and Belowground Biomass Models for Trees in the Miombo Woodlands of Malawi

    Directory of Open Access Journals (Sweden)

    Daud J. Kachamba

    2016-02-01

    Full Text Available In this study we present general (multiple tree species from several sites above- and belowground biomass models for trees in the miombo woodlands of Malawi. Such models are currently lacking in the country. The modelling was based on 74 trees comprising 33 different species with diameters at breast height (dbh and total tree height (ht ranging from 5.3 to 2 cm and from 3.0 to 25.0 m, respectively. Trees were collected from four silvicultural zones covering a wide range of conditions. We tested different models including dbh, ht and wood specific gravity ( ρ as independent variables. We evaluated model performance using pseudo-R2, root mean square error (RMSE, a covariance matrix for the parameter estimates, mean prediction error (MPE and relative mean prediction error (MPE%. Computation of MPE% was based on leave-one-out cross-validation. Values of pseudo-R2 and MPE% ranged 0.82–0.97 and 0.9%–2.8%, respectively. Model performance indicated that the models can be used over a wide range of geographical and ecological conditions in Malawi.

  9. Shock Spectrum Calculation from Acceleration Time Histories

    Science.gov (United States)

    1980-09-01

    accurate and economical . If the velocity is desired, it can be calculated with Equation A-8b. As it stands it is exact. Approx- imation will be...Washington DC; DAEN-MCE.D (R L Wight) Washington DC; DAEN.MPE-D Washington DC; DAEN- MPU . Washington DC; DARCOM; ERADCOM Tech Supp Dir. (DELSD-L) Ft

  10. Chemsearch Journal Volume 4 Number 1, June, 2013

    African Journals Online (AJOL)

    Magashi

    2013-06-01

    Jun 1, 2013 ... Corrosion Inhibitors for Mild Steel in Hydrochloric Acid Solution. 1Ita, B. I., 1Louis ... ABSTRACT. The corrosion inhibition of mild steel in 2M hydrochloric acid solution by Melon (Cucumismelo)(MPE) and ..... halide ions in HCl.

  11. Ulighed i sundhed

    DEFF Research Database (Denmark)

    Uligheden i sundhed er stigende i Danmark trods et mangeårigt politisk fokus på at bekæmpe den. Bogen bidrager med viden om de komplekse processer, hvori ulighed i sundhed opstår og reproduceres. Bogens kapitler handler bl.a. om: Mænd og sundhed Klasse, sundhed og subjekt Overvægt Mental sundhed,...

  12. Cytomorphologic features of myxopapillary ependymoma: a review of 13 cases.

    Science.gov (United States)

    Takei, Hidehiro; Kosarac, Ognjen; Powell, Suzanne Z

    2009-01-01

    To describe the cytologic features of myxopapillary ependymoma (MPE) on intraoperative smears, to analyze cytomorphologic parameters that may help in reaching the diagnosis and to discuss differential diagnosis. Touch imprint smears of 13 MPE cases were reviewed and graded semiquantitatively for 14 cytomorphologic parameters; cellularity, myxoid background, isolated/dispersed tumor cells, "hyaline globules (HGs)," fibrillary cytoplasmic processes, papillary structures, perivascular pseudorosettes, epithelioid tumor cells (ETCs), intracytoplasmic mucin, intranuclear inclusions, nuclear grooves, mitosis, cytologic atypia and hemosiderin-laden macrophages. Cytologic examination revealed variably cellular specimens composed of isolated and loosely aggregated tumor cells with round to oval or occasionally spindle-shaped nuclei; evenly distributed, finely granular chromatin; and fibrillary processes admixed with occasional ETCs. Most of the cases showed prominent fibrillary processes and occasional ETCs with at least a focal myxoid background. HGs and hemosiderin-laden macrophages were often seen. Papillary structure, a histologic hallmark of MPE, was rarely observed. Dual glial and epithelioid properties of tumor cells, well-known features of "regular" ependymomas, and a distinctive myxoid background with HGs strongly support a diagnosis of MPE and are of great help in excluding other mimics (e.g., other variants of ependymoma, metastatic mucinous adenocarcinoma, metastatic adenoid cystic carcinoma and chordoma).

  13. The behavioral performance tests of Mucuna pruriens gold nanoparticles in the 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine treated mouse model of Parkinsonism

    Directory of Open Access Journals (Sweden)

    Subramanian Arulkumar

    2012-05-01

    Full Text Available Objective: The present investigation is aimed to carry out the behavioural changes of the Mucuna pruriens extract (MPE and Mucuna pruriens Goldnanoparticles (MPGNPs against MPTPinduced neurotoxicity. Methods: MPGNPs prepared from the methanolic extract of Mucuna pruriens seeds using Chloroauricchloride (HAuCl4. The seed powder has been found to show the anti-parkinsonian effects. Mice were induced with 10 mg/kg of MPTP, four injections i.p., at 1 h intervals within 24 h. MPE was administered at the dose 200 mg/kg (i.p and MPGNPs was administered at different doses of 500 毺 g/kg, 5, 10 and 20 mg/kg (i.p in different groups once a day for seven days and the dose on the first day was given 30 min prior to first MPTP injection. Results: The behavioural changes were studied using the rotarod test, hang test and narrow beam test. MPE and MPGNPs significantly (P<0.05 improved the behavioural activities. Conclusions: MPGNPs possesses significant behavioural activity than MPE against MPTP induced neurotoxicity.

  14. Pleurodesis Using Mistletoe Extract Delivered via a Spray Catheter during Semirigid Pleuroscopy for Managing Symptomatic Malignant Pleural Effusion.

    Science.gov (United States)

    Eom, Jung Seop; Ahn, Hyo Yeong; Mok, Jeong Ha; Lee, Geewon; Jo, Eun-Jung; Kim, Mi-Hyun; Lee, Kwangha; Kim, Ki Uk; Park, Hye-Kyung; Lee, Min Ki

    Talc poudrage during thoracoscopy is considered the standard procedure for patients with symptomatic malignant pleural effusion (MPE). Until now, no alternative technique other than talc poudrage for pleurodesis during medical thoracoscopy has been proposed. Liquid sclerosants, such as mistletoe extract, have been sprayed evenly into the pleural cavity during semirigid pleuroscopy for chemical pleurodesis. We conducted a retrospective study using the database of semirigid pleuroscopy to identify the usefulness of pleurodesis using a mistletoe extract delivered via a spray catheter during semirigid pleuroscopy for symptomatic MPE. All consecutive patients with symptomatic MPE who underwent semirigid pleuroscopy from October 2015 to September 2016 were registered. The responses were evaluated using chest X- ray or computed tomography 4 weeks after pleurodesis. The study included 43 patients who underwent pleurodesis with mistletoe extract via a spray catheter during semirigid pleuroscopy. Complete and partial responses were seen in 21 (49%) and 19 (44%) patients, respectively. The median duration of chest tube placement after pleurod-esis was 7 days (range 6-8 days) in the 40 patients with complete or partial responses. No cases of severe hemorrhage, empyema formation, respiratory failure, or procedure-related mortality were observed in the subjects at 4 weeks after semirigid pleuroscopy. Pleurodesis with mistletoe extract delivered via a spray catheter during semirigid pleuroscopy is a safe and effective procedure for managing symptomatic MPE. © 2017 S. Karger AG, Basel.

  15. Energy savings in cooling systems through use of new heat exchanger type with flat aluminium pipes and fins; Energibesparelser i koeleanlaeg ved anvendelse af ny varmevekslertype med flade aluminiumsroer og finner

    Energy Technology Data Exchange (ETDEWEB)

    Mulvad, R. (Aluventa A/S, Svendborg (Denmark)); Schneider, P. (Teknologisk Institut, Koele- og Varmepumpeteknik, AArhus (Denmark))

    2008-12-15

    This report describes the theoretical and practical work carried out to characterize and size air-cooled condensers and evaporators manufactured in MPE-tubes. Test heat exchangers were constructed for which capacity and pressure loss was measured. The measurements are compared with equations from the literature, and the most appropriate equations were selected. An analytical comparison of heat exchangers made with round tubes and fins of different types shows that by using heat exchangers with MPE-tubes and louvered fins lower air side pressure loss and higher performance can be achieved. Similarly, the refrigerant filling in MPE heat exchangers lower than in conventional heat exchangers with round tubes. This has great significance in the choice of heat exchangers because of the high price per kilo of HCF refrigerants. Correlations for heat transfer and pressure loss by condensation / evaporation and correlations for heat transfer and pressure drop were implemented in the calculation programs for design of condensers and evaporators. The calculation programs developed in the project are compared with a non-commercially available program designed for heat exchangers with MPE-tubes. The comparison shows good agreement. (ln)

  16. Romahadet er allemandseje i Danmark

    DEFF Research Database (Denmark)

    Molbæk-Steensig, Helga

    2017-01-01

    Artiklen adresserede politiets twitter-omtale af begrebet ’roma’ som synonym for ’omrejsende kriminel’. Artiklen gjorde opmærksom på Danmarks generelle og specifikke ansvar for at bekæmpe diskrimination, med henvisning til den europæiske menneskerettighedskonventions generelle diskriminationsforbud...

  17. 50 CFR 680.23 - Equipment and operational requirements.

    Science.gov (United States)

    2010-10-01

    ... States accessible by road or regularly scheduled air service; and (5) Provide an approved observer... operator must test each scale or scale system used to weigh CR crab one time during each 24-hour period... accurate and timely manner. (i) Belt scales. The MPE for the daily at-sea scale tests is plus or minus 3...

  18. Analytical Modeling and Simulation of Four-Switch Hybrid Power Filter Working with Sixfold Switching Symmetry

    Czech Academy of Sciences Publication Activity Database

    Tlustý, J.; Škramlík, Jiří; Švec, J.; Valouch, Viktor

    2012-01-01

    Roč. 2012, č. 292178 (2012), s. 1-17 ISSN 1024-123X Institutional support: RVO:61388998 Keywords : analytical modeling * four-switch hybrid power filter * sixfold switching symmetry Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering Impact factor: 1.383, year: 2012 http://www.hindawi.com/journals/mpe/2012/292178/

  19. Exorcising the ghost of the past: The abandonment of obsession ...

    African Journals Online (AJOL)

    2011-06-21

    Jun 21, 2011 ... He goes on to point out that one of the many weaknesses in this approach .... as a contribution to a new genre of writing (the 'Hillbrow genre,' ... of women and children, crime, substance abuse, lack of respect for the next .... Mpe uses dialogue in Welcome to Our Hillbrowto try and offset such a victimisation.

  20. Implementation Guidance Document: Properties and Types of Significant Photothermal Retinal Lesion Injuries

    Science.gov (United States)

    2017-04-17

    Include area code) (703) 432-0899 Standard Form 298 (Rev. 8/98) Prescribed 1::r;< ANSI S1d. Z39.18 Adobe Professional 7 .O Properties and Types of...are above MPE yet well below an irradiance that could cause significant retinal injuries. Estimating RSI in Practice - Some Illustrative Examples

  1. Multiscale permutation entropy analysis of electrocardiogram

    Science.gov (United States)

    Liu, Tiebing; Yao, Wenpo; Wu, Min; Shi, Zhaorong; Wang, Jun; Ning, Xinbao

    2017-04-01

    To make a comprehensive nonlinear analysis to ECG, multiscale permutation entropy (MPE) was applied to ECG characteristics extraction to make a comprehensive nonlinear analysis of ECG. Three kinds of ECG from PhysioNet database, congestive heart failure (CHF) patients, healthy young and elderly subjects, are applied in this paper. We set embedding dimension to 4 and adjust scale factor from 2 to 100 with a step size of 2, and compare MPE with multiscale entropy (MSE). As increase of scale factor, MPE complexity of the three ECG signals are showing first-decrease and last-increase trends. When scale factor is between 10 and 32, complexities of the three ECG had biggest difference, entropy of the elderly is 0.146 less than the CHF patients and 0.025 larger than the healthy young in average, in line with normal physiological characteristics. Test results showed that MPE can effectively apply in ECG nonlinear analysis, and can effectively distinguish different ECG signals.

  2. Mikrobiologer ser bakterier i kortene

    DEFF Research Database (Denmark)

    Harmsen, Morten; Sternberg, Claus; Haagensen, Janus Anders Juul

    2008-01-01

    at klumpe sig sammen i slimede biofilm, som især er et stort problem på hospitalerne og hos patienter med kroniske infektioner. For at kunne bekæmpe biofi lm må forskerne vide mere om, hvorfor og hvordan filmen dannes. Ny viden inden for mikrobiologien og udviklingen af nanoteknologiske mikroskoper hjælper...

  3. Generalized composite multiscale permutation entropy and Laplacian score based rolling bearing fault diagnosis

    Science.gov (United States)

    Zheng, Jinde; Pan, Haiyang; Yang, Shubao; Cheng, Junsheng

    2018-01-01

    Multiscale permutation entropy (MPE) is a recently proposed nonlinear dynamic method for measuring the randomness and detecting the nonlinear dynamic change of time series and can be used effectively to extract the nonlinear dynamic fault feature from vibration signals of rolling bearing. To solve the drawback of coarse graining process in MPE, an improved MPE method called generalized composite multiscale permutation entropy (GCMPE) was proposed in this paper. Also the influence of parameters on GCMPE and its comparison with the MPE are studied by analyzing simulation data. GCMPE was applied to the fault feature extraction from vibration signal of rolling bearing and then based on the GCMPE, Laplacian score for feature selection and the Particle swarm optimization based support vector machine, a new fault diagnosis method for rolling bearing was put forward in this paper. Finally, the proposed method was applied to analyze the experimental data of rolling bearing. The analysis results show that the proposed method can effectively realize the fault diagnosis of rolling bearing and has a higher fault recognition rate than the existing methods.

  4. DNA Empresarial: Uma Análise da Gênese à Operação das Micro e Pequenas Empresas de Santa Catarina

    Directory of Open Access Journals (Sweden)

    Jackson André da Silva

    2014-01-01

    Full Text Available A presente pesquisa tem por objetivo analisar os fa tores ligados à gênese e à operação de Micro e Pequenas Empresas (MPE brasileiras, segund o a percepção dos dirigentes das MPE de Santa Catarina, Estado situado na Região Sul do Brasil, sendo esses fatores importantes para a competitividade e para a longevidade dessas firmas, desde as suas origens. O quadro teórico abrange o contexto das MPE no cenário brasi leiro e catarinense, bem como o levantamento dos fatores de sucesso/fracasso encont rados na literatura nacional e internacional. As percepções foram verificadas medi ante a aplicação de questionários estruturados. A partir do tratamento dos dados, obt eve-se o perfil das empresas e a identificação dos fatores que podem propiciar a com petitividade e a longevidade das MPE. Os resultados evidenciam que os dirigentes pesquisados são mais capazes de influenciar o sucesso do seu empreendimento, por meio da busca pe lo conhecimento do mercado, da habilidade em lidar com situações novas e pelo uso de instrumentos de controle administrativo, do que depender de fatores externos como o acesso a financiamentos, a redução do mercado e a concorrência.

  5. Relating Images, Concepts, and Words.

    Science.gov (United States)

    1979-01-01

    similarity metric and links fo r relatedness. Evidence from language for different kinds of mappings 4 In this section I present more detailed...ua ae mpe noa airpane nd amoutainfromthe tor " Pedo " i Wat Dineys Trasuy, Glde Press NowYork,1953 Page 16 Figure 4 "Collective invention" (1935) by Rene

  6. Plasticized chitosan/polyolefin films produced by extrusion.

    Science.gov (United States)

    Matet, Marie; Heuzey, Marie-Claude; Ajji, Abdellah; Sarazin, Pierre

    2015-03-06

    Plasticized chitosan and polyethylene blends were produced through a single-pass extrusion process. Using a twin-screw extruder, chitosan plasticization was achieved in the presence of an acetic acid solution and glycerol, and directly mixed with metallocene polyethylene, mPE, to produce a masterbatch. Different dilutions of the masterbatch (2, 5 and 10 wt% of plasticized chitosan), in the presence of ethylene vinyl acetate, EVA, were subsequently achieved in single screw film extrusion. Very small plasticized chitosan domains (number average diameter <5 μm) were visible in the polymeric matrix. The resulting films presented a brown color and increasing haze with chitosan plasticized content. Mechanical properties of the mPE films were affected by the presence of plasticized chitosan, but improvement was observed as a result of some compatibility between mPE and chitosan in the presence of EVA. Finally the incorporation of plasticized chitosan affected mPE water vapor permeability while oxygen permeability remained constant. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Ivan Vladislavić and What-What: Among Writers, Readers and “other ...

    African Journals Online (AJOL)

    This essay is an experimental quodlibet on some recent Johannesburg imaginative writing. It works outwards from a creative 'overview' of Ivan Vladislavić's position in South African literature to a perspective on versions of citiness represented by newer, black authors such as Niq Mhlongo and Phaswane Mpe. Unable to ...

  8. Simple principper for livet

    DEFF Research Database (Denmark)

    Knoop, Hans Henrik

    2010-01-01

    fremmer folks oplevelse af at kunne handle frit, ansvarligt, engageret og meningsfuldt - uanset hvem de er - hvilket betyder, at alle får mere energi, mere glæde, bedre processer og bedre resultater ved hjælp af princippet. Og hvis det forekommer besværligt at skulle bekæmpe meningsløsheden, kan man jo...

  9. Vascular Endothelial Growth Factor in Plasma and Pleural Effusion Is a Biomarker for Outcome After Bevacizumab plus Carboplatin-Paclitaxel Treatment for Non-small Cell Lung Cancer with Malignant Pleural Effusion.

    Science.gov (United States)

    Tamiya, Motohiro; Tamiya, Akihiro; Yasue, Tomomi; Nakao, Keiko; Omachi, Naoki; Shiroyama, Takayuki; Tani, Eriko; Hamaguchi, Masanari; Morishita, Naoko; Suzuki, Hidekazu; Okamoto, Norio; Okishio, Kyoichi; Kawaguchi, Tomoya; Atagi, Shinji; Hirashima, Tomonori

    2016-06-01

    Malignant effusion is associated with high serum and plasma levels of vascular endothelial growth factor (VEGF). There are no biomarkers of outcome for bevacizumab treatment in patients with malignant pleural effusion (MPE). We previously reported that carboplatin-paclitaxel plus bevacizumab was effective for patients with advanced non-squamous non-small cell lung cancer (NSCLC) and MPE, although we did not evaluate the relationship between treatment outcomes and plasma or pleural effusion levels of VEGF. Therefore, this study evaluated whether plasma or pleural effusion VEGF might predict bevacizumab treatment outcome. We enrolled 23 patients with NSCLC and MPE between September 2010 and June 2012. Plasma VEGF levels were measured in 19 patients and pleural VEGF levels were measured in 22 patients. Compared to patients with a low plasma VEGF level, patients with a high level exhibited significantly shorter overall survival (OS: 13.8 vs. 6.5 months, p=0.04), progression-free survival (PFS: 8.7 vs. 4.8 months, peffusion, patients with a high VEGF level exhibited significantly shorter OS (19.6 vs. 6.9 months, peffusion may predict the outcome of bevacizumab treatment in patients with NSCLC and MPE. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  10. Elevated pleural effusion IL-17 is a diagnostic marker and outcome predictor in lung cancer patients

    Science.gov (United States)

    2014-01-01

    Background Interleukin 17 (IL-17) is a proinflammatory cytokine produced mainly by CD4+ T-lymphocytes and may be important in tumor cell growth and progression. In this study, we aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of IL-17 in lung cancer patients with malignant pleural effusion (MPE). Methods Pleural effusion samples were collected from 78 lung cancer patients with MPE and from 45 patients with nonmalignant pleural effusion. Pleural fluid concentrations of IL-17 were measured by using enzyme-linked immunosorbent assays. Results Malignant effusion exhibited higher IL-17 levels than nonmalignant effusion (20.49 ± 5.27 pg/ml vs. 13.16 ± 2.25 pg/ml; P < 0.01). Lung cancer patients with pleural fluid IL-17 levels below 15 pg/ml had longer overall survival than those patients with higher levels (10.8 months vs. 4.7 months; P < 0.05). On the basis of multivariate analysis, we found that pleural fluid IL-17 level was an independent prognostic factor in lung cancer patients with MPE. Conclusions Measurement of IL-17 levels might be a useful diagnostic and prognostic test for lung cancer patients with MPE. PMID:24887477

  11. Management of malignant pleural effusion

    NARCIS (Netherlands)

    Boshuizen, R.C.

    2017-01-01

    The first part of this thesis focuses on IPCs (indwelling pleural catheters) in malignant pleural effusion (MPE) management. In an invited review, the (dis)advantages and prejudices of IPCs are described (Chapter1.1). Since costs and reimbursement issues are the main reasons in the Netherlands to

  12. Integration of molecular pathology, epidemiology and social science for global precision medicine.

    Science.gov (United States)

    Nishi, Akihiro; Milner, Danny A; Giovannucci, Edward L; Nishihara, Reiko; Tan, Andy S; Kawachi, Ichiro; Ogino, Shuji

    2016-01-01

    The precision medicine concept and the unique disease principle imply that each patient has unique pathogenic processes resulting from heterogeneous cellular genetic and epigenetic alterations and interactions between cells (including immune cells) and exposures, including dietary, environmental, microbial and lifestyle factors. As a core method field in population health science and medicine, epidemiology is a growing scientific discipline that can analyze disease risk factors and develop statistical methodologies to maximize utilization of big data on populations and disease pathology. The evolving transdisciplinary field of molecular pathological epidemiology (MPE) can advance biomedical and health research by linking exposures to molecular pathologic signatures, enhancing causal inference and identifying potential biomarkers for clinical impact. The MPE approach can be applied to any diseases, although it has been most commonly used in neoplastic diseases (including breast, lung and colorectal cancers) because of availability of various molecular diagnostic tests. However, use of state-of-the-art genomic, epigenomic and other omic technologies and expensive drugs in modern healthcare systems increases racial, ethnic and socioeconomic disparities. To address this, we propose to integrate molecular pathology, epidemiology and social science. Social epidemiology integrates the latter two fields. The integrative social MPE model can embrace sociology, economics and precision medicine, address global health disparities and inequalities, and elucidate biological effects of social environments, behaviors and networks. We foresee advancements of molecular medicine, including molecular diagnostics, biomedical imaging and targeted therapeutics, which should benefit individuals in a global population, by means of an interdisciplinary approach of integrative MPE and social health science.

  13. Genetic variation in CFH predicts phenytoin-induced maculopapular exanthema in European-descent patients.

    Science.gov (United States)

    McCormack, Mark; Gui, Hongsheng; Ingason, Andrés; Speed, Doug; Wright, Galen E B; Zhang, Eunice J; Secolin, Rodrigo; Yasuda, Clarissa; Kwok, Maxwell; Wolking, Stefan; Becker, Felicitas; Rau, Sarah; Avbersek, Andreja; Heggeli, Kristin; Leu, Costin; Depondt, Chantal; Sills, Graeme J; Marson, Anthony G; Auce, Pauls; Brodie, Martin J; Francis, Ben; Johnson, Michael R; Koeleman, Bobby P C; Striano, Pasquale; Coppola, Antonietta; Zara, Federico; Kunz, Wolfram S; Sander, Josemir W; Lerche, Holger; Klein, Karl Martin; Weckhuysen, Sarah; Krenn, Martin; Gudmundsson, Lárus J; Stefánsson, Kári; Krause, Roland; Shear, Neil; Ross, Colin J D; Delanty, Norman; Pirmohamed, Munir; Carleton, Bruce C; Cendes, Fernando; Lopes-Cendes, Iscia; Liao, Wei-Ping; O'Brien, Terence J; Sisodiya, Sanjay M; Cherny, Stacey; Kwan, Patrick; Baum, Larry; Cavalleri, Gianpiero L

    2018-01-23

    To characterize, among European and Han Chinese populations, the genetic predictors of maculopapular exanthema (MPE), a cutaneous adverse drug reaction common to antiepileptic drugs. We conducted a case-control genome-wide association study of autosomal genotypes, including Class I and II human leukocyte antigen (HLA) alleles, in 323 cases and 1,321 drug-tolerant controls from epilepsy cohorts of northern European and Han Chinese descent. Results from each cohort were meta-analyzed. We report an association between a rare variant in the complement factor H-related 4 ( CFHR4 ) gene and phenytoin-induced MPE in Europeans ( p = 4.5 × 10 -11 ; odds ratio [95% confidence interval] 7 [3.2-16]). This variant is in complete linkage disequilibrium with a missense variant (N1050Y) in the complement factor H ( CFH ) gene. In addition, our results reinforce the association between HLA-A*31:01 and carbamazepine hypersensitivity. We did not identify significant genetic associations with MPE among Han Chinese patients. The identification of genetic predictors of MPE in CFHR4 and CFH, members of the complement factor H-related protein family, suggest a new link between regulation of the complement system alternative pathway and phenytoin-induced hypersensitivity in European-ancestral patients. Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

  14. Solar Observations on Magneto-Convection

    Science.gov (United States)

    1989-05-31

    Technical Library National Solar Observatory Sunspot, NM 88349 Karl - Schwarzschild -Strasse 1 8046 Garching bei Mundhen Solar Observations On Magneto...Schmidt, Hermann-Ulrich Schmidt, Hans-Christoph Thomas (eds.) Max-Planck-Institut fir Physik und Astrophysik Institut fiur Astrophysik Karl ... Schwarzschild -St-. 1 D-8046 Garching, FklG 14TIS CRiA.&l DTIC TA. U~Jar,iou8:ed B ......... ... Distribution I -- Availability COcý----- Avail and or Dist special

  15. The Hamburg Ocean-Atmosphere Parameters and Fluxes from Satellite Data (HOAPS): A climatological atlas of satellite-derived air-sea interaction parameters over the world oceans

    Digital Repository Service at National Institute of Oceanography (India)

    Grassl, H.; Jost, V.; Schulz, J.; RameshKumar, M.R.; Bauer, P.; Schluessel, P.

    and the corresponding atmospheric circulation over this region has profound influence on the global weather and climate. In the past, several authors have made important contributions in the form of atlases mostly using ship data (Baumgartner and Reichel, 1975... available to interested users for non-commercial scientific research. For details of how to access the fields see: http:// www.mpimet.mpg.de/Depts/Physik/HOAPS. 1 Chapter I Introduction Oceans play a very important role in the global climate system...

  16. Forschungspolitik USA weisen zunehmend ausländische Physikstudenten ab

    Science.gov (United States)

    Bührke, Thomas

    2003-11-01

    In keinem anderen Land der Erde ist der Anteil ausländischer Studenten im Fach Physik größer als in den USA. Nach den Terroranschlägen vom 11. September werden jedoch zunehmend ausländische Studenten, insbesondere aus China und dem mittleren Osten, abgewiesen - zum Leidwesen der Studenten und der Universitäten.http://www.aip.org/statistics

  17. General relativity 50 years old

    CERN Multimedia

    1966-01-01

    In May 1916, 'The Foundations of General Relativity Theory' by Albert Einstein was published in 'Annalen der Physik'. Fifty years later, this major contribution to scientific thought still has a rather isolated position with respect to the main-stream of scientific theory. (In contrast, the Special Theory of Relativity is one of the cornerstones of sub-nuclear physics.) To mark the anniversary of the publication of Einstein's paper a theoretician from CERN discusses the theory and its present status.

  18. Characterization of the first true coaxial 18-fold segmented n-type prototype HPGe detector for the gerda project

    International Nuclear Information System (INIS)

    Abt, I.; Caldwell, A.; Gutknecht, D.; Kroeninger, K.; Lampert, M.; Liu, X.; Majorovits, B.; Quirion, D.; Stelzer, F.; Wendling, P.

    2007-01-01

    The first true coaxial 18-fold segmented n-type HPGe prototype detector produced by Canberra-France for the GERDA neutrinoless double beta-decay project was tested both at Canberra-France and at the Max-Planck-Institut fur Physik in Munich. The main characteristics of the detector are given and measurements concerning detector properties are described. A novel method to establish contacts between the crystal and a Kapton cable is presented

  19. Untitled

    Indian Academy of Sciences (India)

    Proc. Nat. Acad. Sci., U.S.A., 1929, 15, 896. 5. D. N. Read & sº ... Phys. Rev., 1934, 46, 571. 6. D. Coster and F. Brons ... Physica, 1934, 1, 155; Nature, 1934, 133, 140. 7. W. W. Watson ... ... Phys. Rev., 1932, 42, 509. -. 8. R. de L. Kronig .. . . Zs. f. Physik, 1928, 50, 347. 9. J. Kaplan * * ... Phys. Rev., 1930, 36, 788. 10. L. Gerő .

  20. Compiling Planning into Quantum Optimization Problems: A Comparative Study

    Science.gov (United States)

    2015-06-07

    to SAT, and then reduces higher order terms to quadratic terms through a series of gadgets . Our mappings allow both positive and negative preconditions...to its being specific to this type of problem) and likely benefits from an homogeneous parameter setting (Venturelli et al. 2014), as it generates a...Guzik, A. 2013. Resource efficient gadgets for compiling adiabatic quan- tum optimization problems. Annalen der Physik 525(10- 11):877–888. Blum, A

  1. Co-Sponsorship of 1999 Conference on the Dynamics of Molecular Collision (17th) held in Lake Harmony, Pennslyvania on 18-23 July 1999.

    Science.gov (United States)

    2000-02-25

    Cambridge, Cambridge CB2 1EW, U.K. Fernando Castafio and Maria N. Sanchez Rayo Departamento de Quimica Fisica, Universidad del Pais Vasco, Apartado...Welge Fakultät für Physik. Universität Bielefeld, Germany F.J. Aoiz, L. Banares, J.F. Castillo, B. Marti’nez-Haya Departamento de Quimica Fisica...8656 Tokyo, Japan M A.J.C. Varandas • Departamento de Quimica Sangwoon Yoon Universidade de

  2. Big Bang 5

    CERN Document Server

    Apolin, Martin

    2007-01-01

    Physik soll verständlich sein und Spaß machen! Deshalb beginnt jedes Kapitel in Big Bang mit einem motivierenden Überblick und Fragestellungen und geht dann von den Grundlagen zu den Anwendungen, vom Einfachen zum Komplizierten. Dabei bleibt die Sprache einfach, alltagsorientiert und belletristisch. Der Band 5 RG behandelt die Grundlagen (Maßsystem, Größenordnungen) und die Mechanik (Translation, Rotation, Kraft, Erhaltungssätze).

  3. Big Bang 8

    CERN Document Server

    Apolin, Martin

    2008-01-01

    Physik soll verständlich sein und Spaß machen! Deshalb beginnt jedes Kapitel in Big Bang mit einem motivierenden Überblick und Fragestellungen und geht dann von den Grundlagen zu den Anwendungen, vom Einfachen zum Komplizierten. Dabei bleibt die Sprache einfach, alltagsorientiert und belletristisch. Band 8 vermittelt auf verständliche Weise Relativitätstheorie, Kern- und Teilchenphysik (und deren Anwendungen in der Kosmologie und Astrophysik), Nanotechnologie sowie Bionik.

  4. Big Bang 6

    CERN Document Server

    Apolin, Martin

    2008-01-01

    Physik soll verständlich sein und Spaß machen! Deshalb beginnt jedes Kapitel in Big Bang mit einem motivierenden Überblick und Fragestellungen und geht dann von den Grundlagen zu den Anwendungen, vom Einfachen zum Komplizierten. Dabei bleibt die Sprache einfach, alltagsorientiert und belletristisch. Der Band 6 RG behandelt die Gravitation, Schwingungen und Wellen, Thermodynamik und eine Einführung in die Elektrizität anhand von Alltagsbeispielen und Querverbindungen zu anderen Disziplinen.

  5. Big Bang 7

    CERN Document Server

    Apolin, Martin

    2008-01-01

    Physik soll verständlich sein und Spaß machen! Deshalb beginnt jedes Kapitel in Big Bang mit einem motivierenden Überblick und Fragestellungen und geht dann von den Grundlagen zu den Anwendungen, vom Einfachen zum Komplizierten. Dabei bleibt die Sprache einfach, alltagsorientiert und belletristisch. In Band 7 werden neben einer Einführung auch viele aktuelle Aspekte von Quantenmechanik (z. Beamen) und Elektrodynamik (zB Elektrosmog), sowie die Klimaproblematik und die Chaostheorie behandelt.

  6. Introdução ao Projeto de um Sistema da Filosofia da Natureza ou Sobre o Conceito da Fí­sica Especulativa e a Organização interna de um Sistema desta Ciência 1799

    Directory of Open Access Journals (Sweden)

    Friedrich W. J. Schelling

    2011-05-01

    Full Text Available Traduçáo do original alemáo: Schelling, F. W. J. "Einleitung zu dem Entwurf eines Systems der Naturphilosophie oder über den Begriff der speculativen Physik und die innere Organisation eines Systems dieser Wissenschaft". In: Schelling, K. F. A. (Org.. Sämmtliche Werke. 14 Bdn. 1 Abt. I-X; 2 Abt. I-IV, Stuttgart/Augsburg: Cota, 1856-1861.

  7. [The value of B7-H4 and carcinoembryonic antigen in diagnosing the benign and malignant pleural effusion].

    Science.gov (United States)

    Wei, F; Wei, Y; Li, L F; Li, G L; Wang, G J

    2017-07-23

    Objective: To evaluate the value of combined detection of negative costimulatory molecule B7-H4 and carcinoembryonic antigen (CEA) in diagnosing malignant and benign pleural effusion. Methods: Ninety-seven pleural effusion specimen were collected, 55 of which were diagnosed as malignant pleural effusion and 42 were benign pleural effusion. Enzyme-linked immunosorbent assay(ELISA) was used to examine the concentration of B7-H4 and CEA in pleural effusion. Electro-chemiluminescence immunoassay was used to detect the CEA level in pleural effusion. Receiver operating characteristic (ROC) curve was established to analyze and evaluate the single or combined detection of B7-H4 and CEA in diagnosing malignant and benign pleural effusion. Results: The concentrations of B7-H4 and CEA in malignant pleural effusion (MPE) group were (60.08±35.04) ng/ml and (41.49±37.16) ng/ml, respectively, obviously higher than (27.26±9.55) ng/ml and (2.41±0.94) ng/ml of benign pleural effusion (BPE) group (both P 37.25 ng/ml or CEA>4.18 ng/ml, the sensitivity of diagnosis as MPE was down-regulated to 90.9% and the specificity was elevated to 88.1%. When B7-H4 >37.25 ng/ml and CEA>4.18 ng/ml, the sensitivity of diagnosis as MPE was down-regulated to 78.2% and the specificity was elevated to 97.6%. The sensitivity and specificity of combined detection of B7-H4 and CEA to diagnose MPE were elevated to 90.9% and 97.6%, respectively. The level of B7-H4 in MPE and BPE were both positively correlated with CEA ( r =0.670, P =0.001 in MPE and r =0.002, P =0.001 in BEP). Conclusions: B7-H4 is a potential tumor marker in diagnosing the benign and malignant pleural effusion. Although the diagnostic value of B7-H4 may not precede to CEA, the combined detection of B7-H4 and CEA can improve the diagnostic sensitivity and specificity of MPE.

  8. Efficacy of sonographic and biological pleurodesis indicators of malignant pleural effusion (SIMPLE): protocol of a randomised controlled trial

    Science.gov (United States)

    Piotrowska, Hania E G; Yousuf, Ahmed; Kanellakis, Nikolaos I; Kagithala, Gayathri; Mohammed, Seid; Clifton, Lei; Corcoran, John P; Russell, Nicky; Dobson, Melissa; Miller, Robert F; Rahman, Najib M

    2017-01-01

    Introduction Malignant pleural effusion (MPE) is common and currently in UK there are an estimated 50 000 new cases of MPE per year. Talc pleurodesis remains one of the most popular methods for fluid control. The value of thoracic ultrasound (TUS) imaging, before and after pleurodesis, in improving the quality and efficacy of care for patients with MPE remains unknown. Additionally, biomarkers of successful pleurodesis including measurement of pleural fluid proteins have not been validated in prospective studies. The SIMPLE trial is an appropriately powered, multicentre, randomised controlled trial designed to assess ’by the patient bedside' use of TUS imaging and pleural fluid analysis in improving management of MPE. Methods and analysis 262 participants with a confirmed MPE requiring intervention will be recruited from hospitals in UK and The Netherlands. Participants will be randomised (1:1) to undergo either chest drain insertion followed by instillation of sterile talc, or medical thoracoscopy and simultaneous poudrage. The allocated procedure will be done while the patient is hospitalised, and within 3 days of randomisation. Following hospital discharge, participants will be followed up at 1, 3 and 12 months. The primary outcome measure is the length of hospital stay during initial hospitalisation. Ethics and dissemination The trial has received ethical approval from the South Central-Oxford C Research Ethics Committee (Reference number 15/SC/0600). The Trial Steering Committee includes an independent chair and members, and a patient representative. The trial results will be published in a peer-reviewed journal and presented at international conferences. Trial registration number ISRCTN: 16441661. PMID:29225889

  9. Plasma and pleural fluid pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small-cell lung cancer with pleural effusion.

    Science.gov (United States)

    Masago, Katsuhiro; Togashi, Yosuke; Fukudo, Masahide; Terada, Tomohiro; Irisa, Kaoru; Sakamori, Yuichi; Kim, Young Hak; Mio, Tadashi; Inui, Ken-Ichi; Mishima, Michiaki

    2011-09-01

    Erlotinib is orally active and selectively inhibits the tyrosine kinase activity of the epidermal growth factor receptor. The pleural space penetration and exposure of erlotinib is poorly understood. Thus, we investigated the pharmacokinetics (PK) of erlotinib and its active metabolite OSI-420 in non-small-cell lung cancer (NSCLC) of malignant pleural effusion (MPE). We analyzed the PK of erlotinib and OSI-420 on days 1 and 8 after beginning erlotinib therapy in 9 patients with MPE. Their concentrations were determined by high-performance liquid chromatography with ultraviolet detection. Blood samples were obtained five times per day: before administration, and 2, 4, 8, and 24 hours after administration. Pleural effusions were obtained once per day, 2 hours after administration on day 1, and before administration on day 8. The exceptions were cases 2 and 4, which had pleural effusions obtained just before drug administration, and 2, 4, 8, and 24 hours after administration. The mean percentage of penetration from plasma to pleural effusion for erlotinib was 18% on day 1 and 112% on day 8, while these values for OSI-420 were 9.5% on day 1 and 131% on day 8. The area under the drug concentration-time curve of pleural fluid for erlotinib was 28,406 ng-hr/mL for case 2 and 45,906 ng-hr/mL for case 4. There seems to be a significant accumulation of both erlotinib and OSI-420 in MPE with repeated dosing. Although larger studies will be necessary to determine the true impact of erlotinib MPE accumulation on plasma PK and safety, erlotinib can be administered safely to patients with MPE with respect to efficacy and side effects. Copyright © 2011. Published by Elsevier Inc.

  10. Management of Pediatric Myxopapillary Ependymoma: The Role of Adjuvant Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Agbahiwe, Harold C.; Wharam, Moody [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Batra, Sachin [Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Cohen, Kenneth [Division of Pediatric Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States); Terezakis, Stephanie A., E-mail: sterezak@jhmi.edu [Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (United States)

    2013-02-01

    Introduction: Myxopapillary ependymoma (MPE) is a rare tumor in children. The primary treatment is gross total resection (GTR), with no clearly defined role for adjuvant radiation therapy (RT). Published reports, however, suggest that children with MPE present with a more aggressive disease course. The goal of this study was to assess the role of adjuvant RT in pediatric patients with MPE. Methods: Sixteen patients with MPE seen at Johns Hopkins Hospital (JHH) between November 1984 and December 2010 were retrospectively reviewed. Fifteen of the patients were evaluable with a mean age of 16.8 years (range, 12-21 years). Kaplan-Meier curves and descriptive statistics were used for analysis. Results: All patients received surgery as the initial treatment modality. Surgery consisted of either a GTR or a subtotal resection (STR). The median dose of adjuvant RT was 50.4 Gy (range, 45-54 Gy). All patients receiving RT were treated at the involved site. After a median follow-up of 7.2 years (range, 0.75-26.4 years), all patients were alive with stable disease. Local control at 5 and 10 years was 62.5% and 30%, respectively, for surgery alone versus 100% at both time points for surgery and adjuvant RT. Fifty percent of the patients receiving surgery alone had local failure. All patients receiving STR alone had local failure compared to 33% of patients receiving GTR alone. One patient in the surgery and adjuvant RT group developed a distant site of recurrence 1 year from diagnosis. No late toxicity was reported at last follow-up, and neurologic symptoms either improved or remained stable following surgery with or without RT. Conclusions: Adjuvant RT improved local control compared to surgery alone and should be considered after surgical resection in pediatric patients with MPE.

  11. Motor Planning Error: Toward Measuring Cognitive Frailty in Older Adults Using Wearables

    Directory of Open Access Journals (Sweden)

    He Zhou

    2018-03-01

    Full Text Available Practical tools which can be quickly administered are needed for measuring subtle changes in cognitive–motor performance over time. Frailty together with cognitive impairment, or ‘cognitive frailty’, are shown to be strong and independent predictors of cognitive decline over time. We have developed an interactive instrumented trail-making task (iTMT platform, which allows quantification of motor planning error (MPE through a series of ankle reaching tasks. In this study, we examined the accuracy of MPE in identifying cognitive frailty in older adults. Thirty-two older adults (age = 77.3 ± 9.1 years, body-mass-index = 25.3 ± 4.7 kg/m2, female = 38% were recruited. Using either the Mini-Mental State Examination or Montreal Cognitive Assessment (MoCA, 16 subjects were classified as cognitive-intact and 16 were classified as cognitive-impaired. In addition, 12 young-healthy subjects (age = 26.0 ± 5.2 years, body-mass-index = 25.3 ± 3.9 kg/m2, female = 33% were recruited to establish a healthy benchmark. Subjects completed the iTMT, using an ankle-worn sensor, which transforms ankle motion into navigation of a computer cursor. The iTMT task included reaching five indexed target circles (including numbers 1-to-3 and letters A&B placed in random order on the computer-screen by moving the ankle-joint while standing. The ankle-sensor quantifies MPE through analysis of the pattern of ankle velocity. MPE was defined as percentage of time deviation between subject’s maximum ankle velocity and the optimal maximum ankle velocity, which is halfway through the reaching pathway. Data from gait tests, including single task and dual task walking, were also collected to determine cognitive–motor performance. The average MPE in young-healthy, elderly cognitive-intact, and elderly cognitive-impaired groups was 11.1 ± 5.7%, 20.3 ± 9.6%, and 34.1 ± 4.2% (p < 0.001, respectively. Large effect sizes (Cohen’s d = 1.17–4.56 were observed for

  12. A Importância do Planejamento Tributário nas Micro e Pequenas Empresas

    Directory of Open Access Journals (Sweden)

    Lucilaine Escobar Teixeira Sampaio

    2015-06-01

    Full Text Available O objetivo geral deste estudo é demonstrar a importância do planejamento tributário para as micro e pequenas empresas (MPE no Brasil. Já os alvos específicos são: identificar as formas de tributação existentes que podem ser utilizadas pelas MPE e verificar qual é a mais viável. Para atingir os objetivos deste estudo, foi realizada pesquisa bibliográfica a partir de artigos e livros do acervo da Faculdade Anhanguera, da Universidade Católica Dom Bosco (UCDB e de acervos pessoais, bem como de artigos de periódicos e legislação disponíveis na internet e manuais de pesquisa no site do Serviço Brasileiro de Apoio às Micro e Pequenas Empresas (Sebrae. Dos resultados encontrados, verificou-se que as MPE possuem papel relevante para a economia e, por esse motivo, o governo, nas últimas décadas, tem proporcionado vários incentivos visando estimular a abertura de mais empresas desse porte, bem como evitar que muitas entrem em falência, tendo em vista que pesquisas realizadas, principalmente pelo Sebrae, demonstram que é alto o índice de MPE que entram em falência todos os anos. Nas últimas décadas, após os incentivos adotados, entre eles a criação do Simples, nova forma de tributação especial para as MPE, verificou-se uma redução no fechamento de empresas desse porte, porém, o índice continua elevado. Várias são as causas para a falência das MPE, e dentre elas se destaca a alta carga tributária. Dessa forma, torna-se imprescindível que os empresários invistam na realização do planejamento tributário, a fim de escolher a melhor forma de tributação para evitar a falência.

  13. Development and validation of a medical chart review checklist for symptom management performance of oncologists in the routine care of patients with advanced cancer.

    Science.gov (United States)

    Blum, David; Rosa, Daniel; deWolf-Linder, Susanne; Hayoz, Stefanie; Ribi, Karin; Koeberle, Dieter; Strasser, Florian

    2014-12-01

    Oncologists perform a range of pharmacological and nonpharmacological interventions to manage the symptoms of outpatients with advanced cancer. The aim of this study was to develop and test a symptom management performance checklist (SyMPeC) to review medical charts. First, the content of the checklist was determined by consensus of an interprofessional team. The SyMPeC was tested using the data set of the SAKK 96/06 E-MOSAIC (Electronical Monitoring of Symptoms and Syndromes Associated with Cancer) trial, which included six consecutive visits from 247 patients. In a test data set (half of the data) of medical charts, two people extracted and quantified the definitions of the parameters (content validity). To assess the inter-rater reliability, three independent researchers used the SyMPeC on a random sample (10% of the test data set), and Fleiss's kappa was calculated. To test external validity, the interventions retrieved by the SyMPeC chart review were compared with nurse-led assessment of patient-perceived oncologists' palliative interventions. Five categories of symptoms were included: pain, fatigue, anorexia/nausea, dyspnea, and depression/anxiety. Interventions were categorized as symptom specific or symptom unspecific. In the test data set of 123 patients, 402 unspecific and 299 symptom-specific pharmacological interventions were detected. Nonpharmacological interventions (n = 242) were mostly symptom unspecific. Fleiss's kappa for symptom and intervention detections was K = 0.7 and K = 0.86, respectively. In 1003 of 1167 visits (86%), there was a match between SyMPeC and nurse-led assessment. Seventy-nine percent (195 of 247) of patients had no or one mismatch. Chart review by SyMPeC seems reliable to detect symptom management interventions by oncologists in outpatient clinics. Nonpharmacological interventions were less symptom specific. A template for documentation is needed for standardization. Copyright © 2014 American Academy of Hospice and

  14. Comparison of NEXRAD multisensor precipitation estimates to rain gage observations in and near DuPage County, Illinois, 2002–12

    Science.gov (United States)

    Spies, Ryan R.; Over, Thomas M.; Ortel, Terry W.

    2018-05-21

    In this report, precipitation data from 2002 to 2012 from the hourly gridded Next-Generation Radar (NEXRAD)-based Multisensor Precipitation Estimate (MPE) precipitation product are compared to precipitation data from two rain gage networks—an automated tipping bucket network of 25 rain gages operated by the U.S. Geological Survey (USGS) and 51 rain gages from the volunteer-operated Community Collaborative Rain, Hail, and Snow (CoCoRaHS) network—in and near DuPage County, Illinois, at a daily time step to test for long-term differences in space, time, and distribution. The NEXRAD–MPE data that are used are from the fifty 2.5-mile grid cells overlying the rain gages from the other networks. Because of the challenges of measuring of frozen precipitation, the analysis period is separated between days with or without the chance of freezing conditions. The NEXRAD–MPE and tipping-bucket rain gage precipitation data are adjusted to account for undercatch by multiplying by a previously determined factor of 1.14. Under nonfreezing conditions, the three precipitation datasets are broadly similar in cumulative depth and distribution of daily values when the data are combined spatially across the networks. However, the NEXRAD–MPE data indicate a significant trend relative to both rain gage networks as a function of distance from the NEXRAD radar just south of the study area. During freezing conditions, of the USGS network rain gages only the heated gages were considered, and these gages indicate substantial mean undercatch of 50 and 61 percent compared to the NEXRAD–MPE and the CoCoRaHS gages, respectively. The heated USGS rain gages also indicate substantially lower quantile values during freezing conditions, except during the most extreme (highest) events. Because NEXRAD precipitation products are continually evolving, the report concludes with a discussion of recent changes in those products and their potential for improved precipitation estimation. An appendix

  15. Diagnostic value of soluble receptor-binding cancer antigen expressed on SiSo cells and carcinoembryonic antigen in differentiating malignant from benign pleural effusion.

    Science.gov (United States)

    Dong, Jiahui; Sun, Gengyun; Zhu, Hongbin

    2016-03-01

    Diagnosis of malignant pleural effusion (MPE) remains a major clinical challenge. The aim of this study was to evaluate the diagnostic value of combined detection of receptor-binding cancer antigen expressed on SiSo cells (RCAS1) and carcinoembryonic antigen (CEA) in patients with MPE and benign pleural effusion (BPE). The serum and pleural fluid samples were collected from 53 patients diagnosed with MPE and 49 patients with BPE. Enzyme-linked immunosorbent assay was used to detect the concentration of RCAS1 in serum and pleural effusion. The clinical data and laboratory information, including CEA levels, were gathered from these cases. The concentration of RCAS1 in MPE was significantly higher than that of BPE (P < 0.001). There was no significant difference between the two serum groups. The diagnostic sensitivity and specificity of pleural fluid RCAS1 were 67.92 and 81.63 %, respectively, at the optimized cutoff value of 7.326 U/mL; meanwhile, the sensitivity and specificity of pleural fluid CEA were 83.02 and 91.84 % at the cutoff value of 3.93 ng/mL. The specificity could be elevated to 98.50 % in serial detection, while the sensitivity may be improved to 94.55 % in parallel detection. Serum RCAS1 concentration was only detected in 53 serum samples out of the 102 samples, indicating that serum RCAS1 may not be a better option in differential diagnosis of malignancies compared with serum CEA, of which the diagnostic sensitivity and specificity were 64.15 and 83.67 % at the cutoff value of 3.90 ng/mL. No significant differences were found in pleural fluid RCAS1 concentration in MPE patients with different ages, gender, and pathological types of lung cancers. The detection of RCAS1 concentration in pleural fluid is informative for the diagnosis of MPE. Joint detection of RCAS1 and CEA can improve the diagnostic sensitivity and specificity. However, the diagnostic value of RCAS1 is not higher than that of CEA.

  16. Cross-Validation of a Glucose-Insulin-Glucagon Pharmacodynamics Model for Simulation using Data from Patients with Type 1 Diabetes

    DEFF Research Database (Denmark)

    Wendt, Sabrina Lyngbye; Ranjan, Ajenthen; Møller, Jan Kloppenborg

    2017-01-01

    three PD model test fits in each of the seven subjects. Thus, we successfully validated the PD model by leave-one-out cross-validation in seven out of eight T1D patients. Conclusions: The PD model accurately simulates glucose excursions based on plasma insulin and glucagon concentrations. The reported...... for concentrations of glucagon, insulin, and glucose. We fitted pharmacokinetic (PK) models to insulin and glucagon data using maximum likelihood and maximum a posteriori estimation methods. Similarly, we fitted a pharmacodynamic (PD) model to glucose data. The PD model included multiplicative effects of insulin...... and glucagon on EGP. Bias and precision of PD model test fits were assessed by mean predictive error (MPE) and mean absolute predictive error (MAPE). Results: Assuming constant variables in a subject across nonoutlier visits and using thresholds of ±15% MPE and 20% MAPE, we accepted at least one and at most...

  17. Effect of synthetic mica on the thermal properties of poly(lactic acid

    Directory of Open Access Journals (Sweden)

    Diego Holanda Saboya Souza

    2014-01-01

    Full Text Available Poly(lactic acid/Somasif fluoromica nanocomposites were prepared by melt blending and their thermal properties investigated by DSC, TGA and DMA. Three different types of synthetic mica (Somasif ME-100, Somasif MAE and Somasif MPE were used at different contents (2.5, 5.0 and 7.5 wt %. The melt blending of PLA and these micas is characterized by a considerable reduction in the matrix molecular weight, which decreases when the nanofiller content is increased. For all nanocomposites, the thermal stability increases when mica is added to the polymer, with the Somasif MPE, producing the highest increase of the degradation temperature and highest reduction of Tg.

  18. NASA/Max Planck Institute Barium Ion Cloud Project.

    Science.gov (United States)

    Brence, W. A.; Carr, R. E.; Gerlach, J. C.; Neuss, H.

    1973-01-01

    NASA and the Max Planck Institute for Extraterrestrial Physics (MPE), Munich, Germany, conducted a cooperative experiment involving the release and study of a barium cloud at 31,500 km altitude near the equatorial plane. The release was made near local magnetic midnight on Sept. 21, 1971. The MPE-built spacecraft contained a canister of 16 kg of Ba CuO mixture, a two-axis magnetometer, and other payload instrumentation. The objectives of the experiment were to investigate the interaction of the ionized barium cloud with the ambient medium and to deduce the properties of electric fields in the proximity of the release. An overview of the project is given to briefly summarize the organization, responsibilities, objectives, instrumentation, and operational aspects of the project.

  19. Melanin microcavitation threshold in the near infrared

    Science.gov (United States)

    Schmidt, Morgan S.; Kennedy, Paul K.; Vincelette, Rebecca L.; Schuster, Kurt J.; Noojin, Gary D.; Wharmby, Andrew W.; Thomas, Robert J.; Rockwell, Benjamin A.

    2014-02-01

    Thresholds for microcavitation of isolated bovine and porcine melanosomes were determined using single nanosecond (ns) laser pulses in the NIR (1000 - 1319 nm) wavelength regime. Average fluence thresholds for microcavitation increased non-linearly with increasing wavelength. Average fluence thresholds were also measured for 10-ns pulses at 532 nm, and found to be comparable to visible ns pulse values published in previous reports. Fluence thresholds were used to calculate melanosome absorption coefficients, which decreased with increasing wavelength. This trend was found to be comparable to the decrease in retinal pigmented epithelial (RPE) layer absorption coefficients reported over the same wavelength region. Estimated corneal total intraocular energy (TIE) values were determined and compared to the current and proposed maximum permissible exposure (MPE) safe exposure levels. Results from this study support the proposed changes to the MPE levels.

  20. Modellen

    DEFF Research Database (Denmark)

    Om genopførelsen af Palle Nielsens (f. 1942) værk Modellen fra 1968: en kæmpe legeplads til børn i museet, hvor de kan boltre sig frit: klatre i tove, kravle i trækonstruktioner, arbejde med værktøjer, kaste sig ud i skumgummipuder, male med fingermaling og klæde sig ud i kostumer......Om genopførelsen af Palle Nielsens (f. 1942) værk Modellen fra 1968: en kæmpe legeplads til børn i museet, hvor de kan boltre sig frit: klatre i tove, kravle i trækonstruktioner, arbejde med værktøjer, kaste sig ud i skumgummipuder, male med fingermaling og klæde sig ud i kostumer...

  1. Management of malignant pleural effusion: challenges and solutions

    Science.gov (United States)

    Penz, Erika; Watt, Kristina N; Hergott, Christopher A; Rahman, Najib M; Psallidas, Ioannis

    2017-01-01

    Malignant pleural effusion (MPE) is a sign of advanced cancer and is associated with significant symptom burden and mortality. To date, management has been palliative in nature with a focus on draining the pleural space, with therapies aimed at preventing recurrence or providing intermittent drainage through indwelling catheters. Given that patients with MPEs are heterogeneous with respect to their cancer type and response to systemic therapy, functional status, and pleural milieu, response to MPE therapy is also heterogeneous and difficult to predict. Furthermore, the impact of therapies on important patient outcomes has only recently been evaluated consistently in clinical trials and cohort studies. In this review, we examine patient outcomes that have been studied to date, address the question of which are most important for managing patients, and review the literature related to the expected value for money (cost-effectiveness) of indwelling pleural catheters relative to traditionally recommended approaches. PMID:28694705

  2. QPS/LHC Activities requiring important Tunnel Work During a future long Shutdown

    CERN Document Server

    Dahlerup-Petersen, K

    2011-01-01

    The MPE/circuit protection section is presently establishing a road map for its future LHC activities. The tasks comprise essential consolidation work, compulsory upgrades and extensions of existing machine facilities. The results of a first round of engineering exertion were presented and evaluated at a MPE activity review in December 2010. The technical and financial aspects of this program will be detailed in the ‘QPS Medium and Long-Term Improvement Plan’, to be published shortly. The QPS activities in the LHC tunnel during a future, long shutdown are closely related to this improvement chart. A project-package based program for the interventions has been established and will be presented in this report, together with estimates for the associated human and financial resources necessary for its implementation.

  3. Mathematical Modelling of Optimization of Structures of Monolithic Coverings Based on Liquid Rubbers

    Science.gov (United States)

    Turgumbayeva, R. Kh; Abdikarimov, M. N.; Mussabekov, R.; Sartayev, D. T.

    2018-05-01

    The paper considers optimization of monolithic coatings compositions using a computer and MPE methods. The goal of the paper was to construct a mathematical model of the complete factorial experiment taking into account its plan and conditions. Several regression equations were received. Dependence between content components and parameters of rubber, as well as the quantity of a rubber crumb, was considered. An optimal composition for manufacturing the material of monolithic coatings compositions was recommended based on experimental data.

  4. Spinal tuberculoma in a patient with spinal myxopapillary ependymoma

    Directory of Open Access Journals (Sweden)

    Arora Brijesh

    2010-01-01

    Full Text Available Intramedullary spinal tuberculosis is a clinical curiosity. A 19-year-old female was diagnosed and treated for lumbosacral myxopapllary ependy moma (MPE. Three years later, she presented with back pain and hypoesthesia of the left upper limb. Besides revealing local recurrence, the MRI demonstrated a fresh lesion in the cervicomedullary area. The latter was operated and the histopathology revealed a tuberculoma.

  5. Acquisition Of Rainfall Dataset And The Application For The Automatic Harvester In The Chesapeake Bay Region

    Science.gov (United States)

    Choi, Y.; Piasecki, M.

    2008-12-01

    The objective of this study is the preparation and indexing of rainfall data products for ingestion into the Chesapeake Bay Environmental Observatory (CBEO) node of the CUAHSI/WATERs network. Rainfall products (which are obtained and then processed based on the WSR-88D NEXRAD network) are obtained from the NOAA/NWS Advanced Hydrologic Prediction Service that combines the Multi-sensor Precipitation Estimate (MPE) data generated by the Regional River Forecast Centers and Hydro-NEXRAD rainfall data generated as a service by the University of Iowa. The former is collected on 4*4 km grid (HRAP) with a daily average temporal resolution and the latter on a 1minute*1minute degree grid with hourly values. We have generated a cut-out for the Chesapeake Bay Basin that contains about 9,300 nodes (sites) for the MPE data and about 300,000 nodes (sites) for the Hydro-NEXRAD product. Automated harvesting services have been implemented for both data products. The MPE data is harvested from its download site using ArcGIS which in turn is used to extract the data for the Chesapeake Bay watershed before a scripting program is used to scatter the data into the ODM. The Hydro-NEXRAD is downloaded from a web-based system at the University of Iowa which permits downloads for large scale watersheds organized by Hydraulic Unit Codes (HUC). The resulting ASCII is then automatically parsed and the information stored alongside the MPE data. The two data products stored side-by-side then allows a comparison between them addressing the accuracy and agreement between the methods used to arrive at rainfall data as both use the raw reflectivity data from the WSD-88D system.

  6. Bekæmpelse af rynket rose II

    DEFF Research Database (Denmark)

    Buttenschøn, Rita M.; Ransijn, Johannes

    2014-01-01

    Rynket rose er en invasiv art, der har spredt sig voldsomt gennem de seneste år – ikke kun i Danmark men i hele Europa. Den er svær at bekæmpe, og derfor har Naturstyrelsen Thy og Thisted Kommune i perioden 2010-2013 gennemført en række kontrollerede forsøg med slåning, græsning og kemisk...... bekæmpelse af rynket rose....

  7. Achieving Better Buying Power through Acquisition of Open Architecture Software Systems for Web and Mobile Devices

    Science.gov (United States)

    2016-02-22

    user query, a database management system, (like MySQL or Oracle 11) that stores, queries and updates metadata associated with the requested content...5.2 Common technology (e.g., Ozone widget framework, Java ); and 5.3 Shared infrastructure (Joint Information Environment, MPE, ICITE). 5.4 Data...or may not be subject to proprietary IP licenses or “fair use” doctrine (cf. Oracle v. Google, re: Java APIs, now pending before the SCOTUS): 15.1 Use

  8. Phycoerythrin-specific bilin lyase-isomerase controls blue-green chromatic acclimation in marine Synechococcus.

    Science.gov (United States)

    Shukla, Animesh; Biswas, Avijit; Blot, Nicolas; Partensky, Frédéric; Karty, Jonathan A; Hammad, Loubna A; Garczarek, Laurence; Gutu, Andrian; Schluchter, Wendy M; Kehoe, David M

    2012-12-04

    The marine cyanobacterium Synechococcus is the second most abundant phytoplanktonic organism in the world's oceans. The ubiquity of this genus is in large part due to its use of a diverse set of photosynthetic light-harvesting pigments called phycobiliproteins, which allow it to efficiently exploit a wide range of light colors. Here we uncover a pivotal molecular mechanism underpinning a widespread response among marine Synechococcus cells known as "type IV chromatic acclimation" (CA4). During this process, the pigmentation of the two main phycobiliproteins of this organism, phycoerythrins I and II, is reversibly modified to match changes in the ambient light color so as to maximize photon capture for photosynthesis. CA4 involves the replacement of three molecules of the green light-absorbing chromophore phycoerythrobilin with an equivalent number of the blue light-absorbing chromophore phycourobilin when cells are shifted from green to blue light, and the reverse after a shift from blue to green light. We have identified and characterized MpeZ, an enzyme critical for CA4 in marine Synechococcus. MpeZ attaches phycoerythrobilin to cysteine-83 of the α-subunit of phycoerythrin II and isomerizes it to phycourobilin. mpeZ RNA is six times more abundant in blue light, suggesting that its proper regulation is critical for CA4. Furthermore, mpeZ mutants fail to normally acclimate in blue light. These findings provide insights into the molecular mechanisms controlling an ecologically important photosynthetic process and identify a unique class of phycoerythrin lyase/isomerases, which will further expand the already widespread use of phycoerythrin in biotechnology and cell biology applications.

  9. Cooperative Control of Active Power Filters in Power Systems without Mutual Communication

    Czech Academy of Sciences Publication Activity Database

    Tlustý, J.; Škramlík, Jiří; Švec, J.; Valouch, Viktor

    2010-01-01

    Roč. 2010, č. 517184 (2010), s. 1-13 ISSN 1024-123X R&D Projects: GA AV ČR IAA200760703 Institutional research plan: CEZ:AV0Z20570509 Keywords : active power filter * power system * wireless cooperation Subject RIV: JA - Electronics ; Optoelectronics, Electric al Engineering Impact factor: 0.689, year: 2010 http://www.hindawi.com/journals/mpe/2010/517184.html

  10. A Conceptual Development of Quench Prediction App build on LSTM and ELQA framework

    OpenAIRE

    Mertik, Matej; Wielgosz, Maciej; Skoczeń, Andrzej

    2016-01-01

    This article presents a development of web application for quench prediction in \\gls{te-mpe-ee} at CERN. The authors describe an ELectrical Quality Assurance (ELQA) framework, a platform which was designed for rapid development of web integrated data analysis applications for different analysis needed during the hardware commissioning of the Large Hadron Collider (LHC). In second part the article describes a research carried out with the data collected from Quench Detection System by means of...

  11. OPTIMUM: a protocol for a multicentre randomised controlled trial comparing Out Patient Talc slurry via Indwelling pleural catheter for Malignant pleural effusion vs Usual inpatient Management.

    Science.gov (United States)

    Sivakumar, P; Douiri, A; West, A; Rao, D; Warwick, G; Chen, T; Ahmed, L

    2016-10-18

    The development of malignant pleural effusion (MPE) results in disabling breathlessness, pain and reduced physical capability with treatment a palliative strategy. Ambulatory management of MPE has the potential to improve quality of life (QoL). The OPTIMUM trial is designed to determine whether full outpatient management of MPE with an indwelling pleural catheter (IPC) and pleurodesis improves QoL compared with traditional inpatient care with a chest drain and talc pleurodesis. OPTIMUM is currently open for any centres interested in collaborating in this study. OPTIMUM is a multicentre non-blinded randomised controlled trial. Patients with a diagnosis of MPE will be identified and screened for eligibility. Consenting participants will be randomised 1:1 either to an outpatient ambulatory pathway using IPCs and talc pleurodesis or standard inpatient treatment with chest drain and talc pleurodesis as per British Thoracic Society guidelines. The primary outcome measure is global health-related QoL at 30 days measured using the EORTC QLQ-C30 questionnaire. Secondary outcome measures include breathlessness and pain measured using a 100 mm Visual Analogue Scale and health-related QoL at 60 and 90 days. A sample size of 142 patients is needed to demonstrate a clinically significant difference of 8 points in global health status at 30 days, for an 80% power and a 5% significance level. The study has been approved by the NRES Committee South East Coast-Brighton and Sussex (reference 15/LO/1018). The trial results will be published in peer-reviewed journals and presented at scientific conferences. UKCRN19615 and ISRCTN15503522; Pre-results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  12. Morphologic characteristics of central pulmonary thromboemboli predict haemodynamic response in massive pulmonary embolism.

    Science.gov (United States)

    Podbregar, Matej; Voga, Gorazd; Krivec, Bojan

    2004-08-01

    On hospital admission, the morphology of the central pulmonary artery thromboemboli is an independent predictor of 30-day mortality in patients with massive pulmonary embolism (MPE). This may be due to the differential susceptibility of thromboemboli to thrombolysis. The aim of this study was to assess haemodynamic response to treatment in patients with MPE and morphologically different thromboemboli. Prospective observational study. An 11-bed closed medical ICU at a 860-bed community general hospital. Twelve consecutive patients with shock or hypotension due to MPE and central pulmonary thromboemboli detected by transesophageal echocardiography who were treated with thrombolysis between January 2000 through April 2002. Patients were divided into two groups according to the characteristics of detected central pulmonary thromboemboli: group 1, thrombi with one or more long, mobile parts; and group 2, immobile thrombi. Urokinase infusion was terminated when mixed venous oxygen saturation was stabilized above 60% for 15 min. At 2 h, the total pulmonary vascular resistance index was reduced more in group 1 than group 2 [from 27+/-12 mmHg/(l.min.m(2)) to 14+/-6 mmHg/(l.min.m(2)) (-52%) vs 27+/-8 mmHg/(l.min.m(2)) to 23+/-10 mmHg/(l.min.m(2)) (-15%), respectively, P=0.04]. In group 1 thrombolysis was terminated earlier than group 2 (89+/-40 min vs 210+/-62 min, respectively, P= 0.0024). The cumulative dose of urokinase used in group 1 was lower than group 2 (1.7+/-0.3 M i.u. vs 2.7+/-0.5 M i.u., respectively, P= 0.023). Haemodynamic stabilization is achieved faster in patients with mobile central thromboemboli detected by transesophageal echocardiography during MPE.

  13. 249-IJBCS-Article-Dr Adomou Aristide

    African Journals Online (AJOL)

    Dr Gatsing

    MPE and Traoré D (eds). CAB. International: UK and Cambridge; 19-39. INSAE 2002. Troisième recensement général de la population et de l'habitat. Résultats définitifs: Tableaux statistiques Cotonou,. Bénin, 4p. Lebrun J, Gilbert G. 1954. Une classification écologique des forêts du Congo. Publ. I.N.E.A.C., sér. Sc., 63: 89.

  14. An Ecohydrological Approach to Managing Intermittent and Ephemeral Streams on Department of Defense Lands in the Southwestern United States

    Science.gov (United States)

    2015-01-30

    USDA: United States Department of Agriculture, http://www.usda.gov USLE : Universal Soil Loss Equation, http://topsoil.nserl.purdue.edu/ usle / ix...Modified Soil Adjusted Vegetation Index (Qi et al., 1994) NCDC: National Climatic Data Center NDVI: Normalized Difference Vegetation Index NEXRAD-MPE...www.rapideye.net/ RENDVI: Red Edge Normalized Difference Vegetation Index RS: Remote sensing RSI: Rainfall Seasonality Index SAVI: Soil Adjusted Vegetation

  15. Ventilation i industrien

    DEFF Research Database (Denmark)

    Valbjørn, O.

    I en række afsnit belyses problemer med træk, kulde, varme, og luftforurening på industriens arbejdspladser, og hvordan man ved ventilation og bygningsudformning kan bekæmpe disse gener. Hvert afsnit kan i princippet læses for sig, og anvisningen kan derfor bruges som håndbog, både af de der er...

  16. Operation of the power system 2011; Driften av kraftsystemet 2011

    Energy Technology Data Exchange (ETDEWEB)

    Brekke, Karstein; Ulsberg, Helge

    2012-07-01

    This report has been prepared as a result of the allotment letters for 2012 to the Norwegian Water Resources and Energy Directorate (NVE) of Petroleum and Energy (MPE), which imposes NVE to prepare an annual report on the operation of the power system. The report shall include information and analysis related to the state of the power system, including errors in key transmission links within Norway and abroad. (Author)

  17. Hyperstress

    DEFF Research Database (Denmark)

    Baldursson, Einar Baldvin

    Stress er et stort problem i vores moderne hverdag med det moderne arbejdsliv, der konstant kræver omstillingsparathed. Alligevel forsøger vi at finde 'gamle' og traditionelle løsninger på, hvordan vi skal bekæmpe stress. Denne bog forslår i stedet, at vi finder en ny, fremadrettet forståelse af,...

  18. Activity of antimicrobial peptide mimetics in the oral cavity: II. Activity against periopathogenic biofilms and anti-inflammatory activity

    Science.gov (United States)

    Hua, J; Scott, R.W.; Diamond, G

    2011-01-01

    Whereas periodontal disease is ultimately of bacterial etiology, from multispecies biofilms of gram-negative anaerobic microorganisms, much of the deleterious effects are caused by the resultant epithelial inflammatory response. Hence, development of a treatment that combines anti-biofilm antibiotic activity with anti-inflammatory activity would be of great utility. Antimicrobial peptides (AMPs) such as defensins are naturally occurring peptides that exhibit broad-spectrum activity as well as a variety of immunomodulatory activities. Furthermore, bacteria do not readily develop resistance to these agents. However, clinical studies have suggested that they do not represent optimal candidates for exogenous therapeutic agents. Small-molecule mimetics of these AMPs exhibit similar activities to the parent peptides, in addition to having low toxicity, high stability and low cost. To determine whether AMP mimetics have the potential for treatment of periodontal disease, we examined the activity of one mimetic, mPE, against biofilm cultures of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Metabolic assays as well as culture and biomass measurement assays demonstrated that mPE exhibits potent activity against biofilm cultures of both species. Furthermore, as little as 2 µg ml−1 mPE was sufficient to inhibit interleukin-1β-induced secretion of interleukin-8 in both gingival epithelial cells and THP-1 cells. This anti-inflammatory activity is associated with a reduction in activation of nuclear factor-κB, suggesting that mPE can act both as an anti-biofilm agent in an anaerobic environment and as an anti-inflammatory agent in infected tissues. PMID:21040516

  19. Does Marriage Make Us Healthier? Inter-Country Comparative Evidence from China, Japan, and Korea.

    Science.gov (United States)

    Fu, Rong; Noguchi, Haruko

    2016-01-01

    This study focuses on East Asian countries and investigates the difference in the marriage premium on the health-marriage protection effect (MPE) between younger and older generations and the intra-couple education concordance effect (ECE) on the health of married individuals. This study used inter-country comparative data from China, Japan, and Korea. This study focused on individuals (n = 7,938) in China, Japan, and Korea who were sampled from the 2010 East Asian Social Survey. To investigate MPE and ECE, four health indicators were utilized: a physical and mental components summary (PCS and MCS), self-rated health status (Dself), and happiness level (Dhappy). Ordinary least squares regression was conducted by country- and gender-specific subsamples. We found that the MPE on PCS, MCS, and Dself was more significant for the older generation than for the younger generation in both China and Japan, whereas the results were inconclusive in Korea. With regard to the ECE on happiness (Dhappy), for both men and women, couples tend to be happier when both the husband and the wife are well educated ("higher balanced marriage") compared to couples with a lower level of educational achievement ("lower balanced marriage"). Significant benefits from a "higher balanced marriage" on MCS and Dself were observed for women only. In contrast, no statistically significant differences in health status were observed between "higher balanced marriage" couples and couples with different levels of educational achievements ("upward marriage" or "downward marriage"). This study found that (1) the MPE was more significant for the older generation, and (2) the health gap, particularly the happiness gap, between higher- and lower-balanced married couples was significant. The inter-country comparative findings are useful to explain how the role of marriage (and therefore of family) on health has been diluted due to the progress of industrialization and modernization.

  20. Integration of Molecular Pathology, Epidemiology, and Social Science for Global Precision Medicine

    Science.gov (United States)

    Nishi, Akihiro; Milner, Danny A; Giovannucci, Edward L.; Nishihara, Reiko; Tan, Andy S.; Kawachi, Ichiro; Ogino, Shuji

    2015-01-01

    Summary The precision medicine concept and the unique disease principle imply that each patient has unique pathogenic processes resulting from heterogeneous cellular genetic and epigenetic alterations, and interactions between cells (including immune cells) and exposures, including dietary, environmental, microbial, and lifestyle factors. As a core method field in population health science and medicine, epidemiology is a growing scientific discipline that can analyze disease risk factors, and develop statistical methodologies to maximize utilization of big data on populations and disease pathology. The evolving transdisciplinary field of molecular pathological epidemiology (MPE) can advance biomedical and health research by linking exposures to molecular pathologic signatures, enhancing causal inference, and identifying potential biomarkers for clinical impact. The MPE approach can be applied to any diseases, although it has been most commonly used in neoplastic diseases (including breast, lung and colorectal cancers) because of availability of various molecular diagnostic tests. However, use of state-of-the-art genomic, epigenomic and other omic technologies and expensive drugs in modern healthcare systems increases racial, ethnic and socioeconomic disparities. To address this, we propose to integrate molecular pathology, epidemiology, and social science. Social epidemiology integrates the latter two fields. The integrative social MPE model can embrace sociology, economics and precision medicine, address global health disparities and inequalities, and elucidate biological effects of social environments, behaviors, and networks. We foresee advancements of molecular medicine, including molecular diagnostics, biomedical imaging, and targeted therapeutics, which should benefit individuals in a global population, by means of an interdisciplinary approach of integrative MPE and social health science. PMID:26636627

  1. Predictive Factors and Treatment Outcomes of Tuberculous Pleural Effusion in Patients With Cancer and Pleural Effusion.

    Science.gov (United States)

    Lee, Jaehee; Lee, Yong Dae; Lim, Jae Kwang; Lee, Deok Heon; Yoo, Seung Soo; Lee, Shin Yup; Cha, Seung Ick; Park, Jae Yong; Kim, Chang Ho

    2017-08-01

    Patients with cancer are at an increased risk of tuberculosis. As pleural effusion has great clinical significance in patients with cancer, the differential diagnosis between tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE) is important. However, the predictive factors and treatment outcomes of TPE in patients with cancer have rarely been studied. Confirmed TPE cases identified at cancer diagnosis and during anticancer management from 2008-2015 were retrospectively investigated. Patients in the study included coexisting TPE and cancer (n = 20), MPE (n = 40) and TPE without cancer (n = 40). Control groups were patients with MPE, and patients with TPE without cancer. Clinical, laboratory and pleural fluid characteristics were compared among groups. Treatment outcomes were compared between patients with TPE with and without cancer. In the final analysis, serum C-reactive protein (S-CRP) ≥3.0mg/dL and pleural fluid adenosine deaminase (ADA) ≥40U/L were independent predictors for identifying TPE in patients with cancer having pleural effusion. The combination of S-CRP with pleural fluid ADA using an "or" rule achieved a sensitivity of 100%, whereas both parameters combined in an "and" rule had a specificity of 98%. Treatment outcomes were not different between the TPE groups with and without cancer. S-CRP and pleural fluid ADA levels may be helpful for predicting TPE in patients with cancer with pleural effusion. The combination of these biomarkers provides better information for distinguishing between TPE and MPE in these patients. Treatment outcomes of TPE in patients with cancer are comparable to those in patients without cancer. Copyright © 2017 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

  2. Massive pulmonary embolism: the predisposing and complicating factors, its current diagnostic approaches and critical importance of early diagnostic physical exam

    Directory of Open Access Journals (Sweden)

    Filip A. Konecny

    2006-12-01

    Full Text Available Massive pulmonary embolism (MPE often leads to circulation collapse, a form of shock. The process is set off by thrombus or multiple thrombi dislodgement followed by a rapid perfusion insufficiency of pulmonary arterial system. Patients experience severe hypotension with diastolic and systolic failure with an acute tricuspid regurgitation. On many occasions, release of an obstruction is unattainable and death is occurring frequently within one hour of presentation. A key reported source of MPE is its occurrence as a complication of deep vein thrombosis (DVT. While long-term immobilization and surgery are both directly associated with MPE, others such as previous DVT, malignancy, infectious lung and heart diseases, family thrombophilia, lower limb paralysis and pregnancy have to be considered as risk factors mainly due to its silent nature. Predisposing and complicating risks should be addressed by an early diagnostic physical exam. The clinician might offer a wide variety of diagnostic approaches, combining techniques into algorithms to better deal with the embolism severity. Multiple patient life-style changes and decisions to adhere to the proposed plan should be built up on patient-physician team effort. KEY WORDS: Massive pulmonary embolism, predisposing factors, current diagnostic approaches.

  3. A moment-convergence method for stochastic analysis of biochemical reaction networks.

    Science.gov (United States)

    Zhang, Jiajun; Nie, Qing; Zhou, Tianshou

    2016-05-21

    Traditional moment-closure methods need to assume that high-order cumulants of a probability distribution approximate to zero. However, this strong assumption is not satisfied for many biochemical reaction networks. Here, we introduce convergent moments (defined in mathematics as the coefficients in the Taylor expansion of the probability-generating function at some point) to overcome this drawback of the moment-closure methods. As such, we develop a new analysis method for stochastic chemical kinetics. This method provides an accurate approximation for the master probability equation (MPE). In particular, the connection between low-order convergent moments and rate constants can be more easily derived in terms of explicit and analytical forms, allowing insights that would be difficult to obtain through direct simulation or manipulation of the MPE. In addition, it provides an accurate and efficient way to compute steady-state or transient probability distribution, avoiding the algorithmic difficulty associated with stiffness of the MPE due to large differences in sizes of rate constants. Applications of the method to several systems reveal nontrivial stochastic mechanisms of gene expression dynamics, e.g., intrinsic fluctuations can induce transient bimodality and amplify transient signals, and slow switching between promoter states can increase fluctuations in spatially heterogeneous signals. The overall approach has broad applications in modeling, analysis, and computation of complex biochemical networks with intrinsic noise.

  4. Effect of dietary ethanol extracts of mango (Mangifera indica L.) on lipid oxidation and the color of chicken meat during frozen storage.

    Science.gov (United States)

    Freitas, Ednardo Rodrigues; da Silva Borges, Ângela; Pereira, Ana Lúcia Fernandes; Abreu, Virgínia Kelly Gonçalves; Trevisan, Maria Teresa Salles; Watanabe, Pedro Henrique

    2015-12-01

    The aim of this study was to evaluate the dietary effect of mango extracts on lipid stability and the coloring of broiler chicken breast meat during frozen storage. The treatments consisted of broiler chicken diet without antioxidants (control) and diets containing antioxidants: 200 ppm of butylated hydroxytoluene (BHT), 200 ppm of mango peel extract (MPE), 400 ppm of MPE, 200 ppm of mango seed extract (MSE), and 400 ppm of MSE. The broiler breasts were stored for 90 days and analysis of lipid oxidation and color was performed every 30 days. The thiobarbituric acid reactive substances values increased during storage and at 90 days, but the 400 ppm MSE treatment yielded lower values, indicating greater antioxidant activity. During storage, the lightness values decreased and the redness increased. Additions of 200 ppm BHT and 400 ppm MPE increased yellowness at 60 days of storage. Thus, mango peel and seed extracts added to broiler chicken diets reduce lipid oxidation and maintain color in breast meat during frozen storage, with mango seed extract at 400 ppm being the most effective. © 2015 Poultry Science Association Inc.

  5. Initialization and Restart in Stochastic Local Search: Computing a Most Probable Explanation in Bayesian Networks

    Science.gov (United States)

    Mengshoel, Ole J.; Wilkins, David C.; Roth, Dan

    2010-01-01

    For hard computational problems, stochastic local search has proven to be a competitive approach to finding optimal or approximately optimal problem solutions. Two key research questions for stochastic local search algorithms are: Which algorithms are effective for initialization? When should the search process be restarted? In the present work we investigate these research questions in the context of approximate computation of most probable explanations (MPEs) in Bayesian networks (BNs). We introduce a novel approach, based on the Viterbi algorithm, to explanation initialization in BNs. While the Viterbi algorithm works on sequences and trees, our approach works on BNs with arbitrary topologies. We also give a novel formalization of stochastic local search, with focus on initialization and restart, using probability theory and mixture models. Experimentally, we apply our methods to the problem of MPE computation, using a stochastic local search algorithm known as Stochastic Greedy Search. By carefully optimizing both initialization and restart, we reduce the MPE search time for application BNs by several orders of magnitude compared to using uniform at random initialization without restart. On several BNs from applications, the performance of Stochastic Greedy Search is competitive with clique tree clustering, a state-of-the-art exact algorithm used for MPE computation in BNs.

  6. Summer student final report

    CERN Document Server

    Guzik, Jakub

    2013-01-01

    During my time spent at CERN I worked under the Technology Department of CERN, in the Machine Protection and Electrical Integrity (MPE) Group. The MPE Group supports LHC operations and maintains state of the art technology for magnet circuit protection and interlock systems for the present and future accelerators, magnet test facilities and CERN hosted experiments[1]. As a member of Magnet Powering Interlocks & Software (TE-MPE-MS) section I was involved in three different projects and used not only CERN developed tools like FESA Framework, but also open source C++ frameworks, Google Test and Google Mock. I had a chance to work with Programmable Logic Controllers and real-time devices known as Front End Computers. I was part of a software developer team, and familiarized myself with the Scrum agile software development methodology. The description and results of my work are presented in three parts of this report. Each part describes a separate project created during my participation in the CERN Summer St...

  7. Development and validation of an LC-MS/MS method for simultaneous quantification of levodopa and MD01 in rat plasma and its application to a pharmacokinetic study of mucuna pruriens extract.

    Science.gov (United States)

    Yang, Guangjie; Zhang, Fangrong; Deng, Linfang; Chen, Chang; Cheng, Zhongzhe; Huang, Jiangeng; Liu, Jiangyun; Jiang, Hongliang

    2016-09-01

    Mucuna pruriens, an ancient Indian herbal medicine containing levodopa, is widely used for Parkinson's disease. In order to simultaneously determine levodopa and 1,1-dimethyl-3-carboxy-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (MD01) in rat plasma, an improved LC-MS/MS method was developed and validated for a pharmacokinetic study in rats orally administered levodopa or Mucuna pruriens extract (MPE). Elimination of matrix effect and improvement of extraction recovery were achieved through systematic optimization of reversed-phase and hydrophilic interaction chromatographic conditions together with sample clean-up procedures. A satisfactory chromatographic performance was obtained with a Thermo Aquasil C18 column (50 × 2.1 mm, 3 µm) using acetonitrile and water containing 0.2% formic acid as mobile phases. Futhermore, sodium metabisulfite and formic acid were used as stabilizers in neat solutions as well as rat plasma. The method was validated in a dynamic range of 20.0-10,000 ng/mL for levodopa and MD01; the intra- and inter-day precision and accuracy were acceptable. The method was successfully utilized to determine the levodopa level in plasma samples of rats administered levodopa or MPE. Pharmacokinetic results showed that an increase in the AUC of levodopa was observed in rats following oral administration of multiple doses of MPE. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  8. Intrapleural chemo- and hyperthermotherapies for malignant pleural effusion: a randomized prospective study.

    Science.gov (United States)

    Chen, Wen-Jun; Yuan, Shao-Fei; Yan, Qing-Yuan; Xiong, Jian-Ping; Wang, Sen-Ming; Zheng, Wei-E; Zhang, Wu; Sun, Hong-Yu; Chen, Hua; Wu, Li-Li

    2012-02-01

    The current prospective randomized study was designed to evaluate the safety and efficacy of combined intrapleural cisplatin and OK-432 (picibanil) plus hyperthermotherapy in patients with malignant pleural effusion (MPE). A total of 358 patients with MPE due to end-stage malignancies were enrolled and randomly divided into two groups, A and B: the intrapleural combination of cisplatin and OK-432 with hyperthermotherapy (n = 179) or without hyperthermotherapy (n = 179), respectively. Mild toxicities such as nausea, vomiting or anorexia, bone marrow depression, and pyrexia were similar in both groups. Patients in Group A (with hyperthermotherapy) showed a significantly higher overall response (93.4%) compared to those in Group B (79.8%, χ(2) = 43.11, p .05). After treatment, the quality of life scores were significantly increased in both groups as compared to prior treatment (p < .05). In conclusion, our study suggests that combined intrapleural cisplatin and OK-432 followed by hyperthermotherapy are more effective in the control of MPE and improve patients' quality of life.

  9. Diagnosis and treatment of shock due to massive pulmonary embolism: approach with transesophageal echocardiography and intrapulmonary thrombolysis.

    Science.gov (United States)

    Krivec, B; Voga, G; Zuran, I; Skale, R; Pareznik, R; Podbregar, M; Noc, M

    1997-11-05

    To evaluate the diagnostic value of transesophageal echocardiography (TEE) as an initial diagnostic tool in shocked patients. The second objective was to study therapeutic impact of intrapulmonary thrombolysis in patients with diagnosed massive pulmonary embolism. Prospective observational study. Medical ICU in 800-bed general hospital. Twenty-four consecutive patients with unexplained shock and distended jugular veins. In 18 patients, right ventricular dilatation with global or segmental hypokinesis was documented. In addition, central pulmonary thromboemboli (12 patients), reduced contrast flow in right pulmonary artery (one patient), and right ventricular free wall akinesis (one patient) were found. No additional echocardiographic findings were apparent in four patients. According to pulmonary scintigraphy or autopsy, sensitivity of TEE for diagnosis of massive pulmonary embolism (MPE) in patients with right ventricular dilatation was 92% and specificity was 100%. In patients without right ventricular dilatation, left ventricular dysfunction (four patients) or cardiac tamponade (two patients) was confirmed. Intrapulmonary thrombolysis was evaluated in 11 of 13 patients with MPE. Two patients died prior to attempted thrombolysis. Three patients received streptokinase and eight received urokinase. Twenty-four hours after beginning of treatment, total pulmonary resistance index significantly decreased for 59% and mean pulmonary artery pressure for 31%. Cardiac index increased for 74%. Nine of 11 patients receiving thrombolysis survived to hospital discharge. Bedside TEE is a valuable tool for diagnosis of MPE. It enables immediate intrapulmonary thrombolysis, which seems to be an effective therapeutic alternative in our group of patients with obstructive shock.

  10. Standard and Nonstandard Craniospinal Radiotherapy Using Helical TomoTherapy

    International Nuclear Information System (INIS)

    Parker, William; Brodeur, Marylene; Roberge, David; Freeman, Carolyn

    2010-01-01

    Purpose: To show the advantages of planning and delivering craniospinal radiotherapy with helical TomoTherapy (TomoTherapy Inc., Madison, WI) by presenting 4 cases treated at our institution. Methods and Materials: We first present a standard case of craniospinal irradiation in a patient with recurrent myxopapillary ependymoma (MPE) and follow this with 2 cases requiring differential dosing to multiple target volumes. One of these, a patient with recurrent medulloblastoma, required a lower dose to be delivered to the posterior fossa because the patient had been previously irradiated to the full dose, and the other required concurrent boosts to leptomeningeal metastases as part of his treatment for newly diagnosed MPE. The final case presented is a patient with pronounced scoliosis who required spinal irradiation for recurrent MPE. Results: The four cases presented were planned and treated successfully with Helical Tomotherapy. Conclusions: Helical TomoTherapy delivers continuous arc-based intensity-modulated radiotherapy that gives high conformality and excellent dose homogeneity for the target volumes. Increased healthy tissue sparing is achieved at higher doses albeit at the expense of larger volumes of tissue receiving lower doses. Helical TomoTherapy allows for differential dosing of multiple targets, resulting in very elegant dose distributions. Daily megavoltage computed tomography imaging allows for precision of patient positioning, permitting a reduction in planning margins and increased healthy tissue sparing in comparison with standard techniques.

  11. Multiscale Permutation Entropy Based Rolling Bearing Fault Diagnosis

    Directory of Open Access Journals (Sweden)

    Jinde Zheng

    2014-01-01

    Full Text Available A new rolling bearing fault diagnosis approach based on multiscale permutation entropy (MPE, Laplacian score (LS, and support vector machines (SVMs is proposed in this paper. Permutation entropy (PE was recently proposed and defined to measure the randomicity and detect dynamical changes of time series. However, for the complexity of mechanical systems, the randomicity and dynamic changes of the vibration signal will exist in different scales. Thus, the definition of MPE is introduced and employed to extract the nonlinear fault characteristics from the bearing vibration signal in different scales. Besides, the SVM is utilized to accomplish the fault feature classification to fulfill diagnostic procedure automatically. Meanwhile, in order to avoid a high dimension of features, the Laplacian score (LS is used to refine the feature vector by ranking the features according to their importance and correlations with the main fault information. Finally, the rolling bearing fault diagnosis method based on MPE, LS, and SVM is proposed and applied to the experimental data. The experimental data analysis results indicate that the proposed method could identify the fault categories effectively.

  12. A moment-convergence method for stochastic analysis of biochemical reaction networks

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jiajun [School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275 (China); Nie, Qing [Department of Mathematics, University of California at Irvine, Irvine, California 92697 (United States); Zhou, Tianshou, E-mail: mcszhtsh@mail.sysu.edu.cn [School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275 (China); Guangdong Province Key Laboratory of Computational Science and School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275 (China)

    2016-05-21

    Traditional moment-closure methods need to assume that high-order cumulants of a probability distribution approximate to zero. However, this strong assumption is not satisfied for many biochemical reaction networks. Here, we introduce convergent moments (defined in mathematics as the coefficients in the Taylor expansion of the probability-generating function at some point) to overcome this drawback of the moment-closure methods. As such, we develop a new analysis method for stochastic chemical kinetics. This method provides an accurate approximation for the master probability equation (MPE). In particular, the connection between low-order convergent moments and rate constants can be more easily derived in terms of explicit and analytical forms, allowing insights that would be difficult to obtain through direct simulation or manipulation of the MPE. In addition, it provides an accurate and efficient way to compute steady-state or transient probability distribution, avoiding the algorithmic difficulty associated with stiffness of the MPE due to large differences in sizes of rate constants. Applications of the method to several systems reveal nontrivial stochastic mechanisms of gene expression dynamics, e.g., intrinsic fluctuations can induce transient bimodality and amplify transient signals, and slow switching between promoter states can increase fluctuations in spatially heterogeneous signals. The overall approach has broad applications in modeling, analysis, and computation of complex biochemical networks with intrinsic noise.

  13. [Clinical Value of Cell Block in the Diagnosis of Malignant Pleural Effusion].

    Science.gov (United States)

    Wang, Xintong; Cheng, Fangyuan; Zhong, Diansheng; Zhang, Lisha; Meng, Fanlu; Shao, Yi; Yu, Tao

    2017-06-20

    Malignant pleural effusion (MPE) is due tumor which arises from the mesothelium or metastases from tumor origniating other sites. Generally, the prognosis of MPE is poor, in the premise of reducing the pain of patients, as soon as possible make clear the property of pleural effusion and cause of the disesease, rightly and quickly, providing effective information for subsequent treatment. The cell block of 103 patients by using natural sedimentation or plasma coagulation method combined with HE staining and immunohistochemical staining method maked clear diagnosis and compared with other methods. 90 patients were diagnosed by cell block section from 103 patients who had MPE (diagnostic rate 87.4%); 32 cases were diagnosed by cell block section only, 74 cases pointed out that the pathological type , 23 cases even pointed out the primary lesions; 71 cases examined other invasive methods at the same time, the diagnostic rate was 87.3% and 81.7%; the detection rate of cell block section and cytological smear in detecting malignant tumor cells was 86.7%and 44.0% respectively. Cell block can not only increase the diagnosis, in contrast to cytological smear, and own the same diagnostic rate compared with other invasive methods, but also can confirm pathological type and primary lesion; especially, for other invasive methods, cell block method is a preferable complementary method, and that cell block method maybe the only way for some patients.

  14. Prognostic factors in patients with malignant pleural effusion: Is it possible to predict mortality in patients with good performance status?

    Science.gov (United States)

    Abrao, Fernando Conrado; Peixoto, Renata D'Alpino; de Abreu, Igor Renato Louro Bruno; Janini, Maria Cláudia; Viana, Geisa Garcia; de Oliveira, Mariana Campello; Younes, Riad Naim

    2016-04-01

    The aim of this study was to identify predictors of mortality only in patients with malignant pleural effusion (MPE) showing good performance status which required pleural palliative procedures. All patients with MPE submitted to pleural palliative procedure were enrolled in a prospective study between 2013 and 2014. Patients with Eastern cooperative oncology group (ECOG) score zero, one, and two were considered with good performance status. The possible prognostic factors were tested for significance using the log-rank test (Kaplan-Meier method) and those with significance on univariate analysis were entered into a multivariable Cox model. A total of 64 patients were included in the analysis. Median follow-up time for surviving patients was 263 days. Median survival for the entire cohort was not reached yet. In the multivariate analysis, gastrointestinal primary site (P = 0.006), low albumin concentration in the pleural fluid (P = 0.017), and high serum NLR (P = 0.007) were associated with mortality. In our cohort of ECOG 0-2 patients with MPE submitted to pleural palliative procedures, gastrointestinal malignancy compared to other sites, low pleural fluid albumin and high NLR were significantly associated with mortality. The identification of these prognostic factors may assist the choice of the optimal palliative technique. J. Surg. Oncol. 2016;113:570-574. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

  15. Wie aus dem Nichts etwas entsteht Gespräche über Antimaterie

    CERN Document Server

    AUTHOR|(CDS)2051122

    2018-01-01

    Antimaterie beschäftigt nicht nur Physiker, sondern auch die Phantasie von Science fiction-Autoren, Star Trek-Fans und Laien. Aber was ist eigentlich Antimaterie, und wie stellt man sie her? Kann man sie speichern? Wird sie bald eine Rolle im Alltag spielen? Und warum verdanken wir unsere Existenz – und die unseres Universums – einem winzigen Unterschied zwischen Materie und Antimaterie? Rolf Landua, einer der weltweit führenden Experten auf diesem Gebiet, beantwortet in seinem neuen Buch anschaulich diese und andere Fragen.

  16. Ion Implantation Technology: Proceedings of the International Conference on Ion Implantation Technology (8th) Held at the University of Surrey, Guildford, UK on 30 July - 3 August 1990

    Science.gov (United States)

    1991-01-01

    1988, 13] P. Dierckx, Computing 24 (1980) 349. Vacuum (1990) in press. [4] D.A.G Bruggeman. Annalen der Physik 5 ( 1935 ) 636. T4 Ill. THROUGHPUT...1986) 229try to determine damage depth profiles in ion-im- 11SAG rggan.nnPy2493)6 [121 S.A G Bruggemann, Ann Phys 24 ( 1935 ) 636 planted...34indefinite" point substrate semiconductors [3-7]. defects should reflect the distribution of lightly damaged We have previously reported the results of EPR

  17. Proceedings of the XXVI international symposium Ahrenshoop on the theory of elementary particles

    International Nuclear Information System (INIS)

    Doerfel, B.; Wieczorek, E.

    1993-02-01

    These proceedings contain most of the invited talks and short communications presented at the XXVI th International Symposium Ahrenshoop on the Theory of Elementary Particles which took place from September 9 th to 13 th , 1992 at Wendisch-Rietz near Berlin. The Symposium was organized jointly by the Institute for Elementary Particle Physics of the Humboldt University Berlin, the Institute for Theoretical Physics of the University Hannover, the Sektion Physik of the University Munich, and DESY - Institute for High Energy Physics Zeuthen. See hints under the relevant topics. (orig.)

  18. Atomphysik für Höhlenmenschen und andere Anfänger das Universum von innen : Moleküle, Atome und Elementarteilchen

    CERN Document Server

    Beetz, Jürgen

    2016-01-01

    Jürgen Beetz zeigt zuerst den Ursprung der erdachten Geschichten der Physik aus der Steinzeit, denn vieles ist so einfach, dass es schon Steinzeitmenschen hätten verstehen können. Im Anschluss daran erklärt der Autor den Aufbau von Atomen und sagt etwas zu ihren physikalischen Größen aus. Obwohl „Atom“ eigentlich „unteilbar“ bedeutet, bestehen Atome dennoch aus Teilen – dies erläutert er im Weiteren genau. Schließlich bespricht er die geheimnisvollen „Quanten“ und ihr merkwürdiges Verhalten.

  19. Kosmologie für Höhlenmenschen und andere Anfänger das Universum von aussen : Trabanten, Planeten, Sterne, Galaxien

    CERN Document Server

    Beetz, Jürgen

    2016-01-01

    Jürgen Beetz zeigt zuerst den Ursprung der erdachten Geschichten der Physik aus der Steinzeit, denn vieles ist so einfach, dass es schon Steinzeitmenschen hätten verstehen können. Im Anschluss daran untersucht der Autor das Weltall auf seine Bestandteile: Monde, Planeten, Sterne, Galaxien usw. Daraus ergibt sich die Frage nach dessen Struktur und Dynamik: Ist das Universum ewig, endlos, konstant? Nichts davon: Es hat eine Entstehungsgeschichte, es expandiert und verändert sich – zum Teil aus noch ungeklärten Ursachen. Besonderes Augenmerk richtet er auf die Expansion des Weltalls und die sich daraus ergebenden Folgen.

  20. „Überholen ohne einzuholen“ Die Entwicklung von Technologien für übermorgen in Kernenergie und Mikroelektronik der DDR

    Science.gov (United States)

    Barkleit, Gerhard

    Dem nuklearen Patt zwischen Ostblock und westlichem Staatenbündnis ist es nach weitgehend übereinstimmender Auffassung von Politik und Wissenschaft zu danken, dass der "Kalte Krieg" in der zweiten Hälfte des 20. Jahrhunderts nicht zum weltumfassenden Flächenbrand eskalierte. An der raschen Herstellung dieses Patts waren zwei Dresdner Physiker maßgeblich beteiligt, deren einer im Manhattan-Projekt in den USA gearbeitet hatte und später in England der Spionage für die Sowjetunion und des Verrats des Know-how der Atombombe überführt wurde.

  1. Leologisch! Alltagsrätsel einfach erklärt

    CERN Document Server

    Ludick, Leo

    2013-01-01

    Wie entsteht ein Regenbogen? Warum ist der Himmel blau? Was sind Lichtjahre? Wie ist das mit den Jahreszeiten? Was sind Schwarze Löcher? Lauter Fragen, die Klein und Groß immer wieder beschäftigen. Der Physiker Leo Ludick hat im Lauf der Zeit solche Fragen gesammelt und in seiner Kolumne "Alltagsrätsel" in der Tageszeitung "Oberösterreichische Nachrichten" wöchentlich prägnante und einleuchtende Antworten darauf gegeben. Dieses Büchlein fasst nun diese Erklärungen thematisch sortiert zusammen. Einfach leologisch!

  2. Einstein's Approach to Statistical Mechanics: The 1902-04 Papers

    Science.gov (United States)

    Peliti, Luca; Rechtman, Raúl

    2017-05-01

    We summarize the papers published by Einstein in the Annalen der Physik in the years 1902-1904 on the derivation of the properties of thermal equilibrium on the basis of the mechanical equations of motion and of the calculus of probabilities. We point out the line of thought that led Einstein to an especially economical foundation of the discipline, and to focus on fluctuations of the energy as a possible tool for establishing the validity of this foundation. We also sketch a comparison of Einstein's approach with that of Gibbs, suggesting that although they obtained similar results, they had different motivations and interpreted them in very different ways.

  3. Advances in Inertial Navigation Systems and Components

    Science.gov (United States)

    1981-04-01

    53. VonLaue, A "Zum Versuch von F. Harress ," Annalen der Physik, 4. Folge, Bd 62, Nr 13, 3.444-463 54. Sommerfeld, A., and Runge, Iris, Ann.d.Phys, 4te...Folge, Bd 35, S. 277-298 (1911) 55. Knopt, 0., "Die Versuche von F. Harress Ober Die Geschwindigkeit des Lichtes in Bewegten Korpern," App d. Phys...4te Folge, Bd 62, S 389-447 (1920) 56. Pogany, B., "Urber Eine Wiederholung des Harress Scher. Versuches, (II.Mitteilung)," Ann D. Phys, 4te Folge, Bd

  4. Physics and Materials Science of High Temperature Superconductors

    Science.gov (United States)

    1989-08-26

    30 M. Nikolo: Effect of Texture and Density on Grain Coupling of Sintered Y-Ba-Cu-O Superconductors 11:30 - 12:00 A. SzAsz : The Symmetries and High...The Hall coefficient is always positive and obeys the RH (x T- 1 law . The I Hall mobility p2-I2 < I cm2/V.S. At T < Tc, the thermoelectric power equals...461561 80-6550 Prof. A. Szasz PP Dr. Martin Schwarz PP Eotvos University Angewandte Physik Muzeum Krt. 6-8 Hoechst AG H-1088 Budapest Hungary Gebaeude

  5. Ökophysik: Plaudereien über das Leben auf dem Land, im Wasser und in der Luft

    Science.gov (United States)

    Nachtigall, W.

    Prof. em. Dr. rer. nat. Werner Nachtigall, geb. 1934, war als Zoophysiologe und Biophysiker Leiter des Zoologischen Instituts der Universität des Saarlandes in Saarbrücken. In Forschung und Ausbildung hat er sich insbesondere mit Aspekten der Technischen Biologie und Bionik befasst und mit seinen Forschergruppen viele Basisdaten insbesondere zur Ökologie, Physiologie und Physik des Fliegens und Schwimmens aber auch zur Stabilität beispielsweise der Gräser erarbeitet. Lebewesen überraschen immer wieder durch ihre "Biodiversität", ihre hochspezifischen Ausgestaltungen und Anpassungen.

  6. Symmetriebrechung und Emergenz in der Kosmologie.

    Science.gov (United States)

    Mainzer, K.

    Seit der Antike wird der Aufbau des Universums mit einfachen und regulären (symmetrischen) Grundstrukturen verbunden. Diese Annahme liegt selbst noch den Standardmodellen der relativistischen Kosmologie zugrunde. Demgegenüber läßt sich die Emergenz neuer Strukturen von den Elementarteilchen über Moleküle bis zu den komplexen Systemen des Lebens als Symmetriebrechung verstehen. Symmetriebrechung und strukturelle Komplexität bestimmen die kosmische Evolution. Damit zeichnet sich ein fachübergreifendes Forschungsprogramm von Physik, Chemie und Biologie ab, in dem die Evolution des Universums untersucht werden kann.

  7. The near-Earth and interplanetary plasma

    International Nuclear Information System (INIS)

    Al'pert, Y.L.

    1983-01-01

    This monograph is an extensive revision and expansion of the original paper which first appeared in 1976 in the encyclopedia, Handbuch der Physik. It presents a detailed and comprehensive treatment of wave processes and of the motion of bodies through plasma around moving bodies such as artificial satellites, and with natural plasma waves and oscillations. Contents, abridged: General properties of the near-Earth and interplanetary plasma. Refractive indexes of cold magnetoplasma. Growth rates for the different oscillation branches. Nonlinear effects in a plasma. Group velocity, trajectories, and trapping of electromagnetic waves in a magnetoplasma. Indexes

  8. International Conference on the Physics of Electronic and Atomic Collisions (14th) Held in Palo Alto, California on 24-30 July 1985 (Electronic and Atomic Collisions. Invited Papers)

    Science.gov (United States)

    1985-07-30

    76] A. Zastawny, Acta . Phys. Polonica , A46 (1974) 39. 77] R. GrUnberg, Z. Naturforsch., A24 (169) 1039. 78] R. Grnberg, Z. Naturforsch., A 3 (1978...Rev. A12 (1975) 1825. 24) A.K. Pradhan, Phys. Rev. Lett. 32 (1983) 84. 47 (1981) 79. 25) Jia-Ming Li(C.M. Lee), Acta Physica Sinica 32 (1983) 84. 26...1985) XXX. 33) H. Bethe, Ann. Physik 5(1930) 325. 34) M. Inokuti, Rev. Mod. Phys. 43 (1971) 279. 35) Bo-Cang Tian, Jia-Ming Li(C.M. Lee), Acta Physica

  9. Lots of Small Stars Born in Starburst Region

    Science.gov (United States)

    1999-10-01

    study a starburst region on a star-by-star basis down to this low mass limit. For comparison, the most sensitive observations of the more distant Tarantula Nebula only reach down to a limit of about 1 solar mass. A most important conclusion of this study is that there are lots of sub-solar mass stars in NGC 3603 , i.e., contrary to several theoretical predictions, these low-mass stars do form in violent starbursts ! The overall age of stars in the contraction phase that are located in the innermost region of NGC 3603 was found to be 300,000 - 1,000,000 years. The counts clearly show that this cluster is well populated in sub-solar mass stars. The next steps The team describes these new results in a scientific article ( "Low-mass stars in the massive HII region NGC 3603 - Deep NIR imaging with ANTU/ISAAC") that will appear in the European research journal Astronomy & Astrophysics in December 1999. Further information about related work on NGC 3603 is available at a dedicated webpage. The present VLT data will now be used for continued studies during which the limits of detection and measurement will be further pushed by means of advanced image processing and analysis. It will also be interesting to look further into possible variations of the number of stars with a given mass over the observed field, not least, to compare the new results with other ongoing studies of different regions (although less massive), e.g. with the Hubble Space Telescope and its infrared instrument NICMOS or with ground-based Adaptive Optics instruments. Notes [1] The team consists of Bernhard Brandl (Principal Investigator; Cornell University, Ithaca, New York, USA), Wolfgang Brandner (University of Hawaii, Honolulu, USA), Frank Eisenhauer (Max-Planck-Institut für Extraterrestrische Physik, Garching, Germany), Anthony F.J. Moffat (Université de Montreal, Canada), Francesco Palla (Osservatorio Astrofisico di Arcetri, Florence, Italy) and Hans Zinnecker (Astrophysikalisches Institut Potsdam

  10. Association of HLA-A and HLA-B Alleles with Lamotrigine-Induced Cutaneous Adverse Drug Reactions in the Thai Population

    Directory of Open Access Journals (Sweden)

    Napatrupron Koomdee

    2017-11-01

    Full Text Available Background: Lamotrigine (LTG is commonly used for treatment of epilepsy and bipolar disorder. It is one of the common cause of cutaneous adverse drug reactions (CADR. Clinical symptoms of LTG-induced CADR range from maculopapular exanthema (MPE to severe cutaneous adverse reactions (SCAR. This study aimed to determine the association of the LTG-induced CADR with human leukocyte antigen (HLA alleles in Thai patients.Methods: Fifteen patients with LTG-induced CADR [10 MPE; 4 Stevens–Johnson syndrome; and 1 drug reaction with eosinophilia and systemic symptoms] and 50 LTG-tolerant controls were included in the study. HLA-A and HLA-B genotyping was performed using polymerase chain reaction-sequence-specific oligonucleotides probes.Results: The proportion of HLA-A∗02:07 and HLA-B∗15:02 allele carriers were significantly higher in the LTG-induced CADR group than in the tolerant controls [odds ratio (OR: 7.83; 95% confidence interval (CI: 1.60–38.25; P = 0.013, and OR: 4.89; 95% CI: 1.28–18.67; P = 0.014]. In addition, subjects with HLA-A∗33:03, HLA-B∗15:02, and HLA-B∗44:03 were significantly higher in the LTG-induced MPE group than in the tolerant controls (OR: 8.27; 95% CI: 1.83–37.41; P = 0.005, OR: 7.33; 95% CI: 1.63–33.02; P = 0.005; and OR: 10.29; 95% CI: 1.45–72.81; P = 0.029. In contrast to the LTG-induced MPE group, there were no significant differences between HLA alleles and LTG-induced SCAR group.Conclusion:HLA-A∗02:07 and HLA-B∗15:02 were associated with LTG-induced CADR in Thai patients. We also identified an association between HLA-A∗33:03, HLA-B∗15:02, and HLA-B∗44:03 and LTG-induced MPE in this population. These results suggest that these alleles could be useful screening markers for preventing CADR before LTG treatment in Thai patients, but further replication studies with larger sample sizes are needed.

  11. Evaluating the MSG satellite Multi-Sensor Precipitation Estimate for extreme rainfall monitoring over northern Tunisia

    Directory of Open Access Journals (Sweden)

    Saoussen Dhib

    2017-06-01

    Full Text Available Knowledge and evaluation of extreme precipitation is important for water resources and flood risk management, soil and land degradation, and other environmental issues. Due to the high potential threat to local infrastructure, such as buildings, roads and power supplies, heavy precipitation can have an important social and economic impact on society. At present, satellite derived precipitation estimates are becoming more readily available. This paper aims to investigate the potential use of the Meteosat Second Generation (MSG Multi-Sensor Precipitation Estimate (MPE for extreme rainfall assessment in Tunisia. The MSGMPE data combine microwave rain rate estimations with SEVIRI thermal infrared channel data, using an EUMETSAT production chain in near real time mode. The MPE data can therefore be used in a now-casting mode, and are potentially useful for extreme weather early warning and monitoring. Daily precipitation observed across an in situ gauge network in the north of Tunisia were used during the period 2007–2009 for validation of the MPE extreme event data. As a first test of the MSGMPE product's performance, very light to moderate rainfall classes, occurring between January and October 2007, were evaluated. Extreme rainfall events were then selected, using a threshold criterion for large rainfall depth (>50 mm/day occurring at least at one ground station. Spatial interpolation methods were applied to generate rainfall maps for the drier summer season (from May to October and the wet winter season (from November to April. Interpolated gauge rainfall maps were then compared to MSGMPE data available from the EUMETSAT UMARF archive or from the GEONETCast direct dissemination system. The summation of the MPE data at 5 and/or 15 min time intervals over a 24 h period, provided a basis for comparison. The MSGMPE product was not very effective in the detection of very light and light rain events. Better results were obtained for the slightly

  12. A PARTICIPAÃÃO NA LISTA DE EMPRESAS COM MELHORES PRÃTICAS PARA COM OS FUNCIONÃRIOS E SEU IMPACTO NA PERFORMANCE: UM ESTUDO EMPÃRICO SOB A LÃGICA DA RBV (RESOURCE-BASED VIEW

    Directory of Open Access Journals (Sweden)

    Ludwig Miguel Agurto Berdejo

    2009-09-01

    Full Text Available Neste trabalho empírico, procuram-se evidências do impacto na performance das empresas decorrente da participação da organização na lista de empresas com melhores práticas para com os seus empregados (MPE. O trabalho sustenta-se no construto da resource-based view (RBV da empresa, estruturado em Barney (1991, entendendo a presença da empresa nas listagens de MPE como um recurso idiossincrático e difícil de ser imitado, o que leva a considerar este recurso como uma fonte de vantagem competitiva sustentável. O objetivo deste trabalho é verificar se a presença constante na lista de MPE no período de 2004 a 2006 proporciona uma performance financeira, medida pelo ROA e ROE, e de mercado, medida pelo Q de Tobin, superior em relação a um grupo de empresas comparáveis incluídas dentro de um grupo de controle. O período completo da análise compreende de 2001 a 2006, tendo sido testados 26 pares de empresas. Usando o Teste Wilcoxon, observouse que, para o ano de 2006, as amostras apresentam uma diferença significativa ao nível de 5% para o ROA e de 3% para o ROE evidenciando um melhor desempenho das empresas pertencentes à lista de MPE. Adicionalmente, usando a técnica de dados em painel, observou-se que a variável que denota a quantidade de participações que a empresa possui na listagem das MPE para o período de 2001 a 2006 apresenta significância para um nível menor do que 10%, contribuindo para o modelo do valor da empresa medido pelo Q de Tobin. Desta forma, este trabalho traz evidências que contribuem para demonstrar que a performance foi positivamente impactada pela sustentação de capacidades intangíveis e socialmente complexas. Com a sustentação destas capacidades podendo dificultar a sua imitação por concorrentes atuais e futuros.

  13. Experimental analysis of an air–water heat pump with micro-channel heat exchanger

    International Nuclear Information System (INIS)

    Brignoli, Riccardo; Cecchinato, Luca; Zilio, Claudio

    2013-01-01

    A multi-port extruded (MPE) aluminium flat tube air heat exchanger was compared to a round tube finned coil (FC). The MPE heat exchanger has parallel flow vertical tube configuration with headers in horizontal position and conventional folded louvred fins. The two heat exchangers were mounted on a 10 kW cooling capacity R410A packaged air heat pump. They were sized to approximately obtain the same cooling and heating capacities in chiller and heating mode, respectively. Climatic room steady state tests without frosting phenomena occurring during heat pump operation, demonstrated that the round tube and the flat tube heat exchanger performance are comparable. The MPE heat exchanger was tested with different refrigerant inlet distributor/outlet tubes configurations to investigate the effect of liquid refrigerant distribution. Cycling frosting/defrosting operations were tested with two equivalent machines placed in parallel outdoor and working at full load condition, one of the units was equipped with the MPE heat exchanger while the other mounted a standard finned coil. Penalization factors were analytically introduced to evaluate frosting associated heating energy and energy efficiency degradation. Test results indicate that both the heat pumps are penalized by frost formation but both the penalization factors are higher for the MPE-unit than the FC-unit one in the −6 to 4 °C air dry bulb temperature range. For the two units, a roughly linear dependence of the heating energy penalization factor and of the energy efficiency factor from the difference between outdoor air and saturated air at the evaporation temperature humidity ratio can be pointed out. - Highlights: ► A multi-port aluminium flat tube heat exchanger was compared to a round tube finned one in a heat pump application. ► In steady state tests without frosting the round and the flat tube heat exchanger are comparable. ► Different inlet distributor/outlet tubes configurations were tested to

  14. Depth-area-duration characteristics of storm rainfall in Texas using Multi-Sensor Precipitation Estimates

    Science.gov (United States)

    McEnery, J. A.; Jitkajornwanich, K.

    2012-12-01

    This presentation will describe the methodology and overall system development by which a benchmark dataset of precipitation information has been used to characterize the depth-area-duration relations in heavy rain storms occurring over regions of Texas. Over the past two years project investigators along with the National Weather Service (NWS) West Gulf River Forecast Center (WGRFC) have developed and operated a gateway data system to ingest, store, and disseminate NWS multi-sensor precipitation estimates (MPE). As a pilot project of the Integrated Water Resources Science and Services (IWRSS) initiative, this testbed uses a Standard Query Language (SQL) server to maintain a full archive of current and historic MPE values within the WGRFC service area. These time series values are made available for public access as web services in the standard WaterML format. Having this volume of information maintained in a comprehensive database now allows the use of relational analysis capabilities within SQL to leverage these multi-sensor precipitation values and produce a valuable derivative product. The area of focus for this study is North Texas and will utilize values that originated from the West Gulf River Forecast Center (WGRFC); one of three River Forecast Centers currently represented in the holdings of this data system. Over the past two decades, NEXRAD radar has dramatically improved the ability to record rainfall. The resulting hourly MPE values, distributed over an approximate 4 km by 4 km grid, are considered by the NWS to be the "best estimate" of rainfall. The data server provides an accepted standard interface for internet access to the largest time-series dataset of NEXRAD based MPE values ever assembled. An automated script has been written to search and extract storms over the 18 year period of record from the contents of this massive historical precipitation database. Not only can it extract site-specific storms, but also duration-specific storms and

  15. Maintenance proficiency evaluation test bank

    International Nuclear Information System (INIS)

    Maier, Loran

    2003-01-01

    The Maintenance Proficiency Evaluation Test Bank (MPETB) is an Electric Power Research Institute- (EPRJ-) operated, utility-sponsored means of developing, maintaining, and disseminating secure, high-quality written and performance maintenance proficiency tests. EPRTs charter is to ensure that all tests and test items that go into the Test Bank have been validated, screened for reliability, and evaluated to high standards of psychometric excellence. Proficiency tests of maintenance personnel.(mechanics, electricians, and instrumentation and control [I and C] technicians) are most often used to determine if an experienced employee is capable of performing maintenance tasks without further training. Such tests provide objective evidence for decisions to exempt an employee from what, for the employee, is unnecessary training. This leads to considerable savings in training costs and increased productivity because supervisors can assign personnel to tasks at which their competence is proven. The ultimate objective of proficiency evaluation is to ensure that qualified maintenance personnel are available to meet the maintenance requirements of the plant Numerous task-specific MPE tests (both written and performance) have been developed and validated using the EPRI MPE methodology by the utilities participating in the MPETB project A task-specific MPE consists of a multiple-choice written examination and a multi-step performance evaluation that can be used to assess an individual's present knowledge and skill level for a given maintenance task. The MPETB contains MPEs and test items for the mechanical, electrical, and I and C classifications that are readily available to participating utilities. Presently, utilities are placing emphasis on developing MPEs to evaluate outage-related maintenance tasks that demonstrate the competency and qualifications of plant and contractor personnel before the start of outage work. Utilities are also using the MPE methodology and process to

  16. Relativitätstheorie ein Sachcomic

    CERN Document Server

    Bassett, Bruce

    2012-01-01

    E = mc² – so einfach ist eine Revolution! Nichts ist schneller als Licht! Wie lange noch? Was fangen wir mit einer vierten Dimension an und mit krummen Räumen? Einstein gilt als größter Physiker der Neuzeit, das amerikanische Magazin „Time“ machte ihn sogar zum Mann des Jahrhunderts. Einstein ist das Lieblingsgenie vieler Menschen: ein Radikaler im wissenschaftlichen Arbeiten und engagierter sozialistischer Pazifist. Es ist nun gut hundert Jahre her, seit Einsteins Relativitätstheorie unseren Blick auf Raum, Zeit und Materie revolutionierte. Einsteins Gedankenexperimente sind berüchtigt für ihre Komplexität, aber sie bieten fesselnde Beschreibungen der Grundlagen, auf denen die Welt funktioniert. Relativitätstheorie und Quantentheorie sind die zwei Hauptsäulen der modernen Physik. Dieser Sachcomic nimmt Sie mit auf eine unterhaltsame Bildungsreise durch Raum und Zeit vorbei an Schwarzen Löchern und quer durch Gravitationsfelder (Je schneller Sie lesen, desto jünger werden Sie!!). Sie werden ...

  17. ALOKASI PASOKAN BERDASARKAN PRODUK UNGGULAN UNTUK RANTAI PASOK SAYURAN SEGAR

    Directory of Open Access Journals (Sweden)

    Marimin Marimin

    2007-01-01

    Full Text Available Application of artificial inteligent by using fuzzy logic can be one of way to handle supply chain situation in uncertainty environment. It was widely concern to study a supply chain using fuzzy logic that most needed. Ain of the study was apply fuzzy logic in determination of supply allocation for superior product in vegetables supply chain. Models was developed in three sub models. First was determination vegetables types that superior by using pareto technique and exponential compaarison method (MPE. Second was expert system to determine supply needed and finally was optimizing supply allocation using fuzzy multi-objective linear programming. The model was applied in a vegetables agroindustry that superior product selected was red paprica. Analysis againts model behaviour is conducted for pesimistic and optimistic scenarios. Abstract in Bahasa Indonesia : Penerapan kecerdasan buatan dengan logika fuzzy bisa menjadi salah satu cara untuk mengatasi situasi rantai pasok dalam lingkungan ketidakpastian. Perhatian yang lebih luas untuk pembahasan rantai pasok menggunakan teknik fuzzy masih sangat dibutuhkan. Studi ini bertujuan menerapkan logika fuzzy dalam penentuan alokasi pasokan untuk produk unggulan pada rantai pasok agroindustri sayuran. Model yang terdiri dari tiga sub model. Sub model pertama adalah penentuan jenis sayuran yang diunggulkan menggunakan kombinasi teknik pareto dan metode perbandingan eksponensial (MPE. Sub model kedua adalah sistem pakar untuk menentukan kebutuhan pasokan menggunakan logika fuzzy. Sub model ketiga adalah optimasi alokasi pasokan menggunakan programa linear obyektif majemuk fuzzy. Model yang dibangun kemudian diterapkan pada sebuah perusahaan agroindustri sayuran dengan produk unggulan terpilih adalah paprika merah. Analisis terhadap prilaku model juga dilakukan untuk skenario pesimis dan optimis. Kata kunci: fuzzy, sistem pakar, MPE, obyektif majemuk, sayuran

  18. Mediastinoscope-controlled parasternal fenestration of the pericardium: definitive surgical palliation of malignant pericardial effusion

    Directory of Open Access Journals (Sweden)

    Toth Imre

    2012-06-01

    Full Text Available Abstract Background The tumorous infiltration or carcinosis of the pericardium could cause pericardial effusion in up to one-third of cases of malignancy, thus potentially interfere with the otherwise desirable oncological treatment. The existing surgical methods for the management of pericardial fluid are well-established but are not without limitations in the symptomatic relief of malignant pericardial effusion (MPE. The recurrence rate ranges between 43 and 69% after pericardiocentesis and 9 to 16% after pericardial drainage. The desire to overcome relative limitations of the existing methods led us to explore an alternative approach. Methods The standard armamentarium of the Carlens collar mediastinoscopy procedure was utilized in a Chamberlain parasternal approach of the pericardial sac. The laterality of approach was decided based upon the pleural involvement, as tumor-free pericardiopleural reflection is required. A pericardio-pleural window at least 3 cm in diameter was created. From January 2000 to December 2009, 22 cases were operated on with mediastinoscope-controlled parasternal fenestration (MCPF. Considering the type of the primary tumor, there were 11 lung cancer, 6 breast cancers, 2 haematologic malignancies and in 3 patients the origin of malignancy could not be verified. Results There were no operative deaths. We lost one patient (4.5% in the postoperative hospital period. All of the surviving patients had a minimum of 2 months of symptom-free survival. We detected transient recurrence of MPE in one patient (4.5% 14 days after the MCPF, which disappeared spontaneously after 24 hours. Conclusion The MCPF offers a real alternative in certain cases of pericardial effusion. We recommend this method especially for the definitive surgical palliation of MPE.

  19. Curcumin attenuates morphine antinociceptive tolerance through suppressing up-regulation of spinal Toll-like receptor 4 in rats

    Directory of Open Access Journals (Sweden)

    Fei GAO

    2017-12-01

    Full Text Available Objective To investigate the effects of curcumin (Cur on activation of spinal Toll-like receptor 4 (TLR4 and on the chronic antinociceptive tolerance of morphine. Methods Sixty male Sprague-Dawley rats with successful intrathecal catheterization were randomly divided into four groups (n=15: saline (NS group; morphine (MOR group; curcumin (Cur group and morphine plus curcumin (MOR+Cur group. A morphine tolerance model of rats was induced by intrathecal injection of morphine 15μg, once a day for 7 consecutive days in MOR and MOR+Cur group; 100μg curcumin was administered intrathecally once a day for 7 consecutive days in Cur and MOR+Cur group, 10μl saline was administered intrathecally once a day for 7 consecutive days in NS group. The effect of curcumin intrathecal catheterization on morphine antinociceptive tolerance was explored by the tail flick latency (TFL method and mechanical withdrawal threshold (MWT, and then the maximum possible potential effect (MPE was calculated. The immunofluorescence staining method was applied to detect the effect of curcumin on the activation of lumbar spinal microglia. Real-time PCR and Western blotting were used to evaluate the effect of curcumin on the expression of mRNA and protein of spinal TLR4. Results The %MPE TFL and %MPE MWT increased significantly in MOR+Cur group than in MOR group (P0.05. The lumbar spinal microglia increased markedly and the expressions of polyclonal antibody IBA-1 and TLR4 were significantly up-regulated in MOR group than in NS group (P0.05. Conclusion Curcumin may attenuate chronic morphine antinociceptive tolerance through inhibiting spinal TLR4 up-regulation. DOI: 10.11855/j.issn.0577-7402.2017.12.06

  20. A benchmarking project on the quality of previous guidelines about the management of malignant pleural effusion from the European Society of Thoracic Surgeons (ESTS) Pleural Diseases Working Group.

    Science.gov (United States)

    Bertolaccini, Luca; Bedetti, Benedetta; Brunelli, Alessandro; Marinova, Katerina; Raveglia, Federico; Rocco, Gaetano; Shargall, Yaron; Solli, Piergiorgio; Varela, Gonzalo; Papagiannopoulos, Kostas; Kuzdzal, Jaroslaw; Massard, Gilbert; Ruffini, Enrico; Falcoz, Pierre-Emmanuel; Martinez-Barenys, Carlos; Opitz, Isabelle; Batirel, Hasan F; Toker, Alper; Scarci, Marco

    2017-08-01

    In the European Society of Thoracic Surgeons (ESTS) survey about management of malignant pleural effusions (MPE), 56% of respondents are not informed of any relevant clinical guidelines and 52%, who are aware of the existence of guidelines, declared that they are in need of updating or revision. The ESTS Pleural Diseases Working Group developed a benchmarking project on quality of previous guidelines on the management of MPE. The Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument was used to assess each guideline. Each item was scored on a 7-point scale. Scores for each domain were calculated. Economic data for the nations which have issued the guidelines were collected from the Organisation for Economic Cooperation and Development health statistics database. Six guidelines fitted the inclusion criteria and were assessed. Five out of 6 guidelines were produced by a multinational collaboration. Observers would recommend only 2 guidelines with minimal modification. Two areas that received the best score were clarity of presentation and scope and purpose (objectives and health questions target population). The applicability of guideline domain had the lowest score. Multivariate analysis demonstrated that clarity of presentation, international guidelines and publication through medical journal were related to improved scores. A strong correlation was observed between the measures of economic status. The quality of guidelines assessed by the AGREE II criteria was found to be extremely variable. Guidelines achieving higher AGREE II scores were more likely to come from the European Union with the direct involvement of scientific societies in their development. It was also recognized that some fundamental unanswered questions remain about the management of MPE. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

  1. The purpose of radiation protection monitoring

    International Nuclear Information System (INIS)

    Morgan, K.Z.

    1979-01-01

    In the early period (1942-1960) of nuclear energy programmes with which I was associated, most radiation protection standards seem to have been formulated on the assumption that there is a threshold dose of ionizing radiation below which no radiation damage is expected to result in the lifetime of the exposed individual. It was in this climate of opinion that health physics began as a profession, and levels of maximum permissible exposure (MPE) to external sources of radiation, maximum permissible concentrations in air, water and food, and maximum permissible body burdens of radionuclides inside the human body were set and enforced. Some of the levels of MPE were quite high in comparison with present standards but, fortunately, the health physicists at the national laboratories in which most radiation workers were employed were very conservative; in most cases the average annual exposures were less than 10% of the MPE levels. However, there was not much concern with the man-rem concept, as exemplified by rather high levels of radioactive waste discharged from the plants or placed in temporary holding facilities - where there was a likely possibility of seepage into the environment. This situation was understandable and justifiable at a time when the purpose of radiation protection monitoring was simply to prevent individuals from exceeding a threshold dose. The period of the recent past up to the present time (1978) has been one in which there has been a gradual change from the concept of a threshold dose hypothesis to the linear hypothesis. In this period the International Commission on Radiological Protection (ICRP) and the national standards setting bodies have pointed out that the levels they have selected are based on the linear hypothesis, but in most respects they leave us with the impression that this is most probably a conservative assumption, subject to revision when better data become available. Also, during this period, the concept of exposure As Low As

  2. Modeling extracellular matrix (ECM) alterations in ovarian cancer by multiphoton excited fabrication of stromal models (Conference Presentation)

    Science.gov (United States)

    Campagnola, Paul J.; Ajeti, Visar; Lara, Jorge; Eliceiri, Kevin W.; Patankar, Mansh

    2016-04-01

    A profound remodeling of the extracellular matrix (ECM) occurs in human ovarian cancer but it unknown how this affects tumor growth, where this understanding could lead to better diagnostics and therapeutic approaches. We investigate the role of these ECM alterations by using multiphoton excited (MPE) polymerization to fabricate biomimetic models to investigate operative cell-matrix interactions in invasion/metastasis. First, we create nano/microstructured gradients mimicking the basal lamina to study adhesion/migration dynamics of ovarian cancer cells of differing metastatic potential. We find a strong haptotactic response that depends on both contact guidance and ECM binding cues. While we found enhanced migration for more invasive cells, the specifics of alignment and directed migration also depend on cell polarity. We further use MPE fabrication to create collagen scaffolds with complex, 3D submicron morphology. The stromal scaffold designs are derived directly from "blueprints" based on SHG images of normal, high risk, and malignant ovarian tissues. The models are seeded with different cancer cell lines and this allows decoupling of the roles of cell characteristics (metastatic potential) and ECM structure and composition (normal vs cancer) on adhesion/migration dynamics. We found the malignant stroma structure promotes enhanced migration and proliferation and also cytoskeletal alignment. Creating synthetic models based on fibers patterns further allows decoupling the topographic roles of the fibers themselves vs their alignment within the tissue. These models cannot be synthesized by other conventional fabrication methods and we suggest the MPE image-based fabrication method will enable a variety of studies in cancer biology.

  3. Substantial Differences between Organ and Muscle Specific Tracer Incorporation Rates in a Lactating Dairy Cow.

    Directory of Open Access Journals (Sweden)

    Nicholas A Burd

    Full Text Available We aimed to produce intrinsically L-[1-(13C]phenylalanine labeled milk and beef for subsequent use in human nutrition research. The collection of the various organ tissues after slaughter allowed for us to gain insight into the dynamics of tissue protein turnover in vivo in a lactating dairy cow. One lactating dairy cow received a constant infusion of L-[1-(13C]phenylalanine (450 µmol/min for 96 h. Plasma and milk were collected prior to, during, and after the stable isotope infusion. Twenty-four hours after cessation of the infusion the cow was slaughtered. The meat and samples of the various organ tissues (liver, heart, lung, udder, kidney, rumen, small intestine, and colon were collected and stored. Approximately 210 kg of intrinsically labeled beef (bone and fat free with an average L-[1-(13C]phenylalanine enrichment of 1.8±0.1 mole percent excess (MPE was obtained. The various organ tissues differed substantially in L-[1-(13C]phenylalanine enrichments in the tissue protein bound pool, the highest enrichment levels were achieved in the kidney (11.7 MPE and the lowest enrichment levels in the skeletal muscle tissue protein of the cow (between 1.5-2.4 MPE. The estimated protein synthesis rates of the various organ tissues should be regarded as underestimates, particularly for the organs with the higher turnover rates and high secretory activity, due to the lengthened (96 h measurement period necessary for the production of the intrinsically labeled beef. Our data demonstrates that there are relatively small differences in L-[1-(13C]phenylalanine enrichments between the various meat cuts, but substantial higher enrichment values are observed in the various organ tissues. We conclude that protein turnover rates of various organs are much higher when compared to skeletal muscle protein turnover rates in large lactating ruminants.

  4. Microwave-Assisted Dip Coating of Aloe Vera on Metallocene Polyethylene Incorporated with Nano-Rods of Hydroxyapaptite for Bone Tissue Engineering

    Directory of Open Access Journals (Sweden)

    Hairong Wang

    2017-10-01

    Full Text Available Bone tissue engineering widely explores the use of ceramic reinforced polymer-matrix composites. Among the various widely-used ceramic reinforcements, hydroxyapatite is an undisputed choice due to its inherent osteoconductive nature. In this study, a novel nanocomposite comprising metallocene polyethylene (mPE incorporated with nano-hydroxyapaptite nanorods (mPE-nHA was synthesized and dip coated with Aloe vera after subjecting it to microwave treatment. The samples were characterized using contact angle, Fourier transform infrared spectroscopy (FTIR, scanning electron microscope (SEM, atomic force microscopy (AFM and 3D Hirox microscopy scanning. Contact angle results show that the hydrophilicity of mPE-nHA improved notably with the coating of Aloe vera. The surface topology and increase in surface roughness were observed using the SEM, AFM and 3D Hirox microscopy. Blood compatibility assays of pure mPE and the Aloe vera coated nanocomposite were performed. The prothrombin time (PT was delayed by 1.06% for 24 h Aloe-vera-treated mPE-nHA compared to the pristine mPE-nHA. Similarly, the 24 h Aloe-vera-coated mPE-nHA nanocomposite prolonged the activated partial thromboplastin time (APTT by 41 s against the control of pristine mPE-nHA. The hemolysis percentage was also found to be the least for the 24 h Aloe-vera-treated mPE-nHA which was only 0.2449% compared to the pristine mPE-nHA, which was 2.188%. To conclude, this novel hydroxyapatite-reinforced, Aloe-vera-coated mPE with a better mechanical and anti-thrombogenic nature may hold a great potential to be exploited for bone tissue engineering applications.

  5. Cellular and molecular responses of adult zebrafish after exposure to CuO nanoparticles or ionic copper.

    Science.gov (United States)

    Vicario-Parés, Unai; Lacave, Jose M; Reip, Paul; Cajaraville, Miren P; Orbea, Amaia

    2018-01-01

    Due to their antimicrobial, electrical and magnetic properties, copper nanoparticles (NPs) are suitable for a vast array of applications. Copper can be toxic to biota, making it necessary to assess the potential hazard of copper nanomaterials. Zebrafish (Danio rerio) were exposed to 10 µg Cu/L of CuO NPs of ≈100 nm (CuO-poly) or ionic copper to compare the effects provoked after 3 and 21 days of exposure and at 6 months post-exposure (mpe). At 21 days, significant copper accumulation was only detected in fish exposed to ionic copper. Exposure to both copper forms caused histopathological alterations that could reduce gill functionality, more markedly in the case of ionic copper. Nevertheless, at 6 mpe higher prevalences of gill lesions were detected in fish previously exposed to CuO-poly NPs. No relevant histological alterations were detected in liver, but the lysosomal membrane stability test showed significantly impaired general health status after exposure to both metal forms that lasted up to 6 mpe. 69 transcripts appeared regulated after 3 days of exposure to CuO-poly NPs, suggesting that NPs could produce oxidative stress and reduce metabolism and transport processes. Thirty transcripts were regulated after 21 days of exposure to ionic copper, indicating possible DNA damage. Genes of the circadian clock were identified as the key genes involved in time-dependent differences between the two copper forms. In conclusion, each copper form showed a distinct pattern of liver transcriptome regulation, but both caused gill histopathological alterations and long lasting impaired health status in adult zebrafish.

  6. Comparative metabolomics analysis for the compatibility and incompatibility of kansui and licorice with different ratios by UHPLC-QTOF/MS and multivariate data analysis.

    Science.gov (United States)

    Shen, Juan; Pu, Zong-Jin; Kai, Jun; Kang, An; Tang, Yu-Ping; Shang, Li-Li; Zhou, Gui-Sheng; Zhu, Zhen-Hua; Shang, Er-Xin; Li, Shao-Ping; Cao, Yu-Jie; Tao, Wei-Wei; Su, Shu-Lan; Zhang, Li; Zhou, Huiping; Qian, Da-Wei; Duan, Jin-Ao

    2017-07-01

    Kansui, the root of Euphorbia kansui T.N. Liou ex T.P. Wang (Euphorbiaceae), is a well-known poisonous traditional Chinese medicine (TCM). However, many monographs of TCM indicated that it cannot be co-used with licorice, as kansui-licorice is a typical "eighteen incompatible" medicaments. Our previous studies have indicated that kansui was effective in treating malignant pleural effusion (MPE), and the efficacy could be weakened by the co-use of licorice, even causing serious toxicity at the given ratio. Nevertheless, the actual mechanisms of their dosage-toxicity-efficacy relationship need to be well clarified. The present study aimed to investigate the effect of individual and combined use of kansui and licorice on MPE rats, and explain the underlying mechanisms from a metabolomic perspective. Urine samples were analyzed by ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS). Partial least-squares discriminate analysis (PLS-DA) models were built to evaluate the interaction between kansui and licorice. Seven potential biomarkers contribute to the separation of model group and control group were tentatively identified. And selenoamino acid metabolism and nicotinate and nicotinamide metabolism with the impact-value 0.31 and 0.24, respectively, were filtered out as the most important metabolic pathways. Kansui and kansui-licorice at a ratio of 4:1 can treat MPE rats by adjusting abnormal metabolic pathways to the normal state, while it may have opposite result with kansui-licorice 1:4. The different influences to the two metabolic pathways may partially explain the dosage-toxicity-efficacy relationship of kansui-licorice with different ratios. The results could offer valuable insights into the compatibility property changes for the two herbs. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Sensitivity of Beauveria bassiana conidia to abiotic factors after successive in vitro subcultures

    Directory of Open Access Journals (Sweden)

    Janaina Zorzetti

    2014-09-01

    Full Text Available The aim of this study was to evaluate the effect of in vitro successive subcultures of Beauveria bassiana isolates in different nutritional conditions on conidia heat and UV radiation tolerance and on sensitivity to azoxystrobin fungicide. The fungus was initially inoculated in Alphitobius diaperinus (Coleoptera: Tenebrionidae adults and after its development, the conidia were cultivated in PDA (potato dextrose agar and MPE (medium to produce Beauveria spp. conidia originating the first subculture 1st (A conidia, which were successively multiplied in their media until the 20th cultivation. Conidia taken from the 20th subculture were again inoculated in the insect and after sporulation they were once more multiplied in the media, producing the 1st (B conidia. For the tests, 1st (A, 10th, 20th and 1st (B conidia from the CG 152 and Unioeste 40 isolates were used. Successive subcultures and the medium nutritional conditions interfered on the fungus physiology, and the isolates showed different behaviors. The subcultures on PDA showed higher thermotolerance to Unioeste 40 in all subcultures and to CG 152 just after inoculation in the host. B. bassiana was susceptible to UV radiation, and this characteristic was influenced by the subcultures in different media. Both isolates were more tolerant to UV radiation when subcultivated on MPE, while just for the 40 Unioeste this tolerance increased after host inoculation. The B. bassiana sensitivity to azoxystrobin fungicide was affected after successive subcultures in both medium. Conidia originated in MPE were more resistant to fungicide and the host inoculation increased this tolerance. These results show that it is possible to enhance the fungi efficiency to control pests, through the selection of a virulent isolate, and handling their nutritional conditions during cultivation and host inoculation.

  8. Diagnostic value of tumor markers for lung adenocarcinoma-associated malignant pleural effusion: a validation study and meta-analysis.

    Science.gov (United States)

    Feng, Mei; Zhu, Jing; Liang, Liqun; Zeng, Ni; Wu, Yanqiu; Wan, Chun; Shen, Yongchun; Wen, Fuqiang

    2017-04-01

    Pleural effusion is one of the most common complications of lung adenocarcinoma and is diagnostically challenging. This study aimed to investigate the diagnostic performance of carcinoembryonic antigen (CEA), cytokeratin fragment (CYFRA) 21-1, and cancer antigen (CA) 19-9 for lung adenocarcinoma-associated malignant pleural effusion (MPE) through a validation study and meta-analysis. Pleural effusion samples were collected from 81 lung adenocarcinoma-associated MPEs and 96 benign pleural effusions. CEA, CYFRA 21-1, and CA19-9 were measured by electrochemiluminescence immunoassay. The capacity of tumor markers was assessed with receiver operating characteristic curve analyses and the area under the curve (AUC) was calculated. Standard methods for meta-analysis of diagnostic studies were used to summarize the diagnostic performance of CEA, CYFRA 21-1, and CA19-9 for lung adenocarcinoma-associated MPE. The pleural levels of CEA, CYFRA 21-1, and CA19-9 were significantly increased in lung adenocarcinoma-associated MPE compared to benign pleural effusion. The cut-off points for CEA, CYFRA 21-1, and CA19-9 were optimally set at 4.55 ng/ml, 43.10 μg/ml, and 12.89 U/ml, and corresponding AUCs were 0.93, 0.85, and 0.81, respectively. The combination of CEA, CYFRA 21-1, and CA19-9 increased the sensitivity to 95.06%, with an AUC of 0.95. Eight studies were included in this meta-analysis. CEA showed the best diagnostic performance with pooled sensitivity, specificity, positive/negative likelihood ratio, and diagnostic odds ratio of 0.75, 0.96, 16.01, 0.23, and 81.49, respectively. The AUC was 0.93. CEA, CYFRA 21-1, and CA19-9 play a role in the diagnosis of lung adenocarcinoma-associated MPE. The combination of these tumor markers increases the diagnostic accuracy.

  9. Very High Performance Organic Photonic Devices

    Science.gov (United States)

    2008-01-15

    thought complexity from left (simplest) to right (most complex). Monomeric compounds ( eft ), possible in the world of inorganic semiconductors. Many...60 ±10 4 7 Sht"it M. M.pe) J et 7 r. B 45 lF,xi S R Eft -Ats. hin I 1,,y,)o I jim-.1). Planar OPD TIo Ilion-f~i, , o... App. PM, Leiw 81. 268-270 (Z...of SnPc deposited on ITO, taken in the 0-20 geometry using Cu Kr S.R radiation. (b) Scanning electron microscope (SEM) and tapping moole SR. Forrest

  10. Taegu AB, Korea. Revised Uniform Summary of Surface Weather Observations (RUSSWO). Parts A, C-F.

    Science.gov (United States)

    1981-10-07

    o -’./ ŗ I 6M 1(TAL 17.; 59.119.1 4. ,7676 - - - - 766 1766 El.,,.., IX) Zl’ Z 1 Ib*Ne Obra . Mie.. Ne. of H4e.e. vlii T.,mpe..thw. U...4 27 38 / 3 2 2 9 42 j ’/ 17 .1 1 1 4 ’? ! lI 15 .1 1 1 43 . 13 .1 1 1 1 34 1 11 .11 13 24 1 7 : 1 5 ./ I2 TT6 VIAL 1.625. g4.*󈧜 6. 6 .1 752 744 6

  11. QPS - analysis of main problems, areas to target, possible improvements

    CERN Document Server

    Denz, R

    2012-01-01

    The fault statistics of the LHC Quench Protection System QPS for the LHC run 2011 will be presented and the various fault types explained. Starting with teething and EMC related problems, the tune feedback compatibility, hardware faults of the quench heater power supplies and spurious openings of electrical circuit breakers will be described in more details. Hereby as well the necessary and potential consolidation measures will be discussed. The role of the MPE standby service for the system availability will be addressed. Finally radiation induced faults and the respective mitigation and consolidation measures will be treated as separate subject.

  12. Monitoramento e controle de projetos de desenvolvimento de software para micro e pequenas empresa alinhado ao PMBOK e CMMI

    OpenAIRE

    Pereira, André Marques

    2012-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência de Computação, Florianópolis, 2012. Muitas empresas falham no desenvolvimento de seus projetos e muito se deve a falta de maturidade de seus processos. Analisando o cenário das Micro e Pequenas Empresas (MPE), muitas vezes inexiste alinhamento à modelos e normas atualmente em evidência, talvez explicado pelo fato de que os modelos podem ser muito abrangentes para o cont...

  13. Implementation of Automatic Clustering Algorithm and Fuzzy Time Series in Motorcycle Sales Forecasting

    Science.gov (United States)

    Rasim; Junaeti, E.; Wirantika, R.

    2018-01-01

    Accurate forecasting for the sale of a product depends on the forecasting method used. The purpose of this research is to build motorcycle sales forecasting application using Fuzzy Time Series method combined with interval determination using automatic clustering algorithm. Forecasting is done using the sales data of motorcycle sales in the last ten years. Then the error rate of forecasting is measured using Means Percentage Error (MPE) and Means Absolute Percentage Error (MAPE). The results of forecasting in the one-year period obtained in this study are included in good accuracy.

  14. Review of Electromagnetic Frequency (EMF) Safety Program for Homestead ARB, FL

    Science.gov (United States)

    2012-11-28

    using technique number MSL-7. Calibrations below I GHz were perfonned in a electrical characterist.ics of the cell and the measured net power...Altimeter ( CARA ) 1 per F-16 4 .2-4.2 GHz 100/10 0 .8 2 .4 482 AMXS/MXAAS AN/APG68 Fire Control Radar (FCR) 1 per F-1 6 Classified Classified Classified...A. MPE fot· Upper T ier Electric Magnetic field Powet· Averaging Fr equency Field - nns strength - n ns Density - nns (S) time R ange (t) (E

  15. Liquid and gas chromatography coupled to isotope ratio mass spectrometry for the determination of 13C-valine isotopic ratios in complex biological samples.

    Science.gov (United States)

    Godin, Jean-Philippe; Breuillé, Denis; Obled, Christiane; Papet, Isabelle; Schierbeek, Henk; Hopfgartner, Gérard; Fay, Laurent-Bernard

    2008-10-01

    On-line gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) is commonly used to measure isotopic ratios at natural abundance as well as for tracer studies in nutritional and medical research. However, high-precision (13)C isotopic enrichment can also be measured by liquid chromatography-isotope ratio mass spectrometry (LC-IRMS). Indeed, LC-IRMS can be used, as shown by the new method reported here, to obtain a baseline separation and to measure (13)C isotopic enrichment of underivatised amino acids (Asp, Thr-Ser, Glu, Pro, Gly, Ala, Cys and Val). In case of Val, at natural abundance, the SD(delta(13)C) reported with this method was found to be below 1 per thousand . Another key feature of the new LC-IRMS method reported in this paper is the comparison of the LC-IRMS approach with the conventional GC-C-IRMS determination. To perform this comparative study, isotopic enrichments were measured from underivatised Val and its N(O, S)-ethoxycarbonyl ethyl ester derivative. Between 0.0 and 1.0 molar percent excess (MPE) (delta(13)C= -12.3 to 150.8 per thousand), the calculated root-mean-square (rms) of SD was 0.38 and 0.46 per thousand and the calculated rms of accuracy was 0.023 and 0.005 MPE, respectively, for GC-C-IRMS and LC-IRMS. Both systems measured accurately low isotopic enrichments (0.002 atom percent excess (APE)) with an SD (APE) of 0.0004. To correlate the relative (delta(13)C) and absolute (atom%, APE and MPE) isotopic enrichment of Val measured by the GC-C-IRMS and LC-IRMS devices, mathematical equations showing the slope and intercept of the curves were established and validated with experimental data between 0.0 to 2.3 MPE. Finally, both GC-C-IRMS and LC-IRMS instruments were also used to assess isotopic enrichment of protein-bound (13)C-Val in tibial epiphysis in a tracer study performed in rats. Isotopic enrichments measured by LC-IRMS and GC-C-IRMS were not statistically different (p>0.05). The results of this work indicate that

  16. Uso e Percepção de Licitude de Práticas Ilegais ou Antiéticas de Sobrevivência de Micro e Pequenas Empresas

    Directory of Open Access Journals (Sweden)

    Sérgio Henrique Arruda Cavalcante Forte

    2015-11-01

    Full Text Available Segundo o Sebrae (2013, a taxa de sobrevivência das Micro e Pequenas Empresas (MPE no Brasil vem melhorando, com sobrevivência de 75,6% nos primeiros dois anos de vida. Das sobreviventes, muitas enfrentam dificuldades no mercado, tendo que por vezes optar para o uso de práticas ilícitas ou antiéticas e ainda não se considerando “fora da lei”. Nesse contexto, o objetivo geral é relacionar o uso das práticas ilegais ou antiéticas utilizadas pelas MPE para sobreviverem com a percepção de ilicitude dessas práticas. Esta pesquisa é do tipo descritiva e quantitativa. Após levantamento bibliográfico e pesquisa exploratória com 17 MPE foi realizada uma pesquisa de campo com 102 MPE, com a aplicação de um questionário com 33 variáveis de práticas ilegais ou antiéticas, onde as práticas deveriam ser avaliadas pelo respondente com base no comportamento observado de seus concorrentes, por meio de uma escala Likert, de cinco pontos. Pode-se concluir que todas as práticas investigadas estão sendo utilizadas em algum grau pelos empreendedores, cabendo destacar que para apenas quatro das 33 práticas a percepção de ilicitude se apresentou menor que a de licitude, evidenciando que a maioria (29 de 33 práticas vem sendo utilizada mesmo tendo-se a consciência de que são ilícitas. Pode-se concluir também que das nove práticas destacadas, cinco delas referem-se à evasão fiscal. Percebeu-se que as práticas que ferem diretamente o interesse do consumidor não são vistas como “ilícitas” pelos empreendedores.

  17. The dynamics of climate agreements

    Energy Technology Data Exchange (ETDEWEB)

    Harstadt, Baard [Northwestern Univ., Evanston, IL (United States). Kellogg School of Management

    2010-02-15

    I develop a dynamic model of private provision of public bads allowing investments in technologies. The analysis is tractable and the MPE unique. The framework is used to derive optimal incomplete contracts in a dynamic setting. While the noncooperative equilibrium is very inefficient, short-term contracts can be worse due to hold-up problems. The optimal long-term contract is more ambitious if its length is relatively short and the technological spillover large. The optimal length increases in this externality. With renegotiation, the outcome is first best. The results have several implications for how to design a climate treaty. (orig.)

  18. Staff Association membership is free of charge for the rest of 2017

    CERN Multimedia

    Staff Association

    2017-01-01

    Starting from September 1st, membership of the Staff Association is free for all new members for the period up to the end of 2017. This is to allow you to participate in the Staff Council elections. Indeed, only Employed Members of the Personnel (MPE: staff and fellows) and Associated Members of the Personnel (MPA), who are members of the Staff Association, can: stand for election and become a delegate of the personnel; vote and elect their representatives to the Staff Council. Do not hesitate any longer; join now!

  19. Efficient and simple production of insulin-producing cells from embryonal carcinoma stem cells using mouse neonate pancreas extract, as a natural inducer.

    Directory of Open Access Journals (Sweden)

    Marzieh Ebrahimie

    Full Text Available An attractive approach to replace the destroyed insulin-producing cells (IPCs is the generation of functional β cells from stem cells. Embryonal carcinoma (EC stem cells are pluripotent cells which can differentiate into all cell types. The present study was carried out to establish a simple nonselective inductive culture system for generation of IPCs from P19 EC cells by 1-2 weeks old mouse pancreas extract (MPE. Since, mouse pancreatic islets undergo further remodeling and maturation for 2-3 weeks after birth, we hypothesized that the mouse neonatal MPE contains essential factors to induce in vitro differentiation of pancreatic lineages. Pluripotency of P19 cells were first confirmed by expression analysis of stem cell markers, Oct3/4, Sox-2 and Nanog. In order to induce differentiation, the cells were cultured in a medium supplemented by different concentrations of MPE (50, 100, 200 and 300 µg/ml. The results showed that P19 cells could differentiate into IPCs and form dithizone-positive cell clusters. The generated P19-derived IPCs were immunoreactive to proinsulin, insulin and insulin receptor beta. The expression of pancreatic β cell genes including, PDX-1, INS1 and INS2 were also confirmed. The peak response at the 100 µg/ml MPE used for investigation of EP300 and CREB1 gene expression. When stimulated with glucose, these cells synthesized and secreted insulin. Network analysis of the key transcription factors (PDX-1, EP300, CREB1 during the generation of IPCs resulted in introduction of novel regulatory candidates such as MIR17, and VEZF1 transcription factors, as well as MORN1, DKFZp761P0212, and WAC proteins. Altogether, we demonstrated the possibility of generating IPCs from undifferentiated EC cells, with the characteristics of pancreatic β cells. The derivation of pancreatic cells from EC cells which are ES cell siblings would provide a valuable experimental tool in study of pancreatic development and function as well as rapid

  20. Clinical value of jointly detection serum lactate dehydrogenase/pleural fluid adenosine deaminase and pleural fluid carcinoembryonic antigen in the identification of malignant pleural effusion.

    Science.gov (United States)

    Zhang, Fan; Hu, Lijuan; Wang, Junjun; Chen, Jian; Chen, Jie; Wang, Yumin

    2017-09-01

    Limited data are available for the diagnostic value, and for the diagnostic sensitivity and specificity of joint detection of serum lactate dehydrogenase (sLDH)/pleural fluid adenosine deaminase (pADA) and pleural fluid carcinoembryonic antigen (pCEA) in malignant pleural effusion (MPE). We collected 987 pleural effusion specimens (of which 318 were malignant pleural effusion, 374 were tubercular pleural effusion, and 295 were parapneumonic effusion specimens) from the First Affiliated Hospital of Wenzhou Medical University from July 2012 to March 2016. The pADA, sLDH, pleural fluid LDH (pLDH), serum C-reactive protein (sCRP), pleural fluid protein, pCEA, white blood cell (WBC), and red blood cell (RBC) were analyzed, and the clinical data of each group were collected for statistical analysis. The level of sLDH/pADA, pCEA, and RBC from the MPE group was markedly higher than the tuberculosis pleural effusion (TB) group (Mann-Whitney U=28422.000, 9278.000, 30518, P=.000, .000, .000) and the parapneumonic pleural fluid group (Mann-Whitney U=5972.500, 7113.000, 36750.500, P=.000, .000, .000). The receiver operating characteristic curve ROC showed that the area under the ROC curve (AUC) (=0.924, 0.841) of pCEA and sLDH/pADA (cutoff=4.9, 10.6) were significantly higher than other markers for the diagnosis of MPE. Thus, joint detection of pCEA and sLDH/pADA suggested that the sensitivity, specificity, and AUC was 0.94, 81.70, and 94.32 at the cutoff 0.16 and diagnostic performance was higher than pCEA or sLDH/pADA. Joint detection of sLDH/pADA and pCEA can be used as a good indicator for the identification of benign and MPE with higher sensitivity and specificity than pCEA or sLDH/pADA. © 2016 Wiley Periodicals, Inc.

  1. PREFACE: The 395th Wilhelm and Else Heraeus Seminar: `Time-dependent phenomena in Quantum Mechanics'

    Science.gov (United States)

    Kleber, Manfred; Kramer, Tobias

    2008-03-01

    The 395th Wilhelm and Else Heraeus Seminar: `Time-dependent phenomena in Quantum Mechanics' took place at the Heinrich Fabri Institute in Blaubeuren, Germany, 12-16 September 2007. The conference covered a wide range of topics connected with time-dependent phenomena in quantum mechanical systems. The 20 invited talks and 15 short talks with posters at the workshop covered the historical debate between Schrödinger, Dirac and Pauli about the role of time in Quantum Mechanics (the debate was carried out sometimes in footnotes) up to the almost direct observation of electron dynamics on the attosecond time-scale. Semiclassical methods, time-delay, monodromy, variational principles and quasi-resonances are just some of the themes which are discussed in more detail in the papers. Time-dependent methods also shed new light on energy-dependent systems, where the detour of studying the time-evolution of a quantum states allows one to solve previously intractable problems. Additional information is available at the conference webpage http://www.quantumdynamics.de The organizer would like to thank all speakers, contributors, session chairs and referees for their efforts in making the conference a success. We also gratefully acknowledge the generous financial support from the Wilhelm and Else Heraeus Foundation for the conference and the production of this special volume of Journal of Physics: Conference Series. Manfred Kleber Physik Department T30, Technische Universität München, 85747 Garching, Germany mkleber@ph.tum.de Tobias Kramer Institut I: Theoretische Physik, Universität Regensburg, 93040 Regensburg, Germany tobias.kramer@physik.uni-regensburg.de Guest Editors Front row (from left): W Schleich, E J Heller, J B Delos, H Friedrich, K Richter, M Kleber, P Kramer, M Man'ko, A del Campo, V Man'ko, M Efremov, A Ruiz, M O Scully Middle row: A Zamora, R Aganoglu, T Kramer, J Eiglsperger, H Cruz, P Raab, I Cirac, G Muga, J Larson, V Dodonov, W Becker Back row: A Eckardt, A

  2. Ab initio approach to the ion stopping power at the plasma-solid interface

    Science.gov (United States)

    Bonitz, Michael; Schlünzen, Niclas; Wulff, Lasse; Joost, Jan-Philip; Balzer, Karsten

    2016-10-01

    The energy loss of ions in solids is of key relevance for many applications of plasmas, ranging from plasma technology to fusion. Standard approaches are based on density functional theory or SRIM simulations, however, the applicability range and accuracy of these results are difficult to assess, in particular, for low energies. Here we present an independent approach that is based on ab initio nonequilibrium Green functions theory, e.g. that allows to incorporate electronic correlations effects of the solid. We present the first application of this method to low-temperature plasmas, concentrating on proton and alpha-particle stopping in a graphene layer. In addition to the stopping power we present time-dependent results for the local electron density, the spectral function and the photoemission spectrum that is directly accessible in optical, UV or x-ray diagnostics. http://www.itap.uni-kiel.de/theo-physik/bonitz/.

  3. Technical presentation

    CERN Multimedia

    GS Department

    2010-01-01

    10 March 2010 DYNEOS 10:00 – 12:00 - Main Building, Room B, 61-1-009 Dyneos AG is active in the fields of photonics, laser and high-precision positioning. Our highly qualified engineer team has more than 30 years of experience in electro-optical solutions sales. The engineers are supported by a technical and administrative team. We are focused on the Swiss market and represent six suppliers (Coherent, PI Physik Instrumente, SIOS, Nanonics Imaging, APE, Ekspla) in order to give a qualified sales and service support to our customers. Our products are dedicated to the research field as well as to industry. In addition to standard catalog products, we offer custom designs to fulfill the specific needs of OEM customers or specific applications.

  4. Wer im Treibhaus sitzt wie wir der Klima- und Energiefalle entkommen

    CERN Document Server

    Kleinknecht, Konrad

    2007-01-01

    Deutschland leistet sich eine verlogene Debatte um die Zukunftsfrage schlechthin: Wie entkommen wir der Energie- und Klimafalle? Mit Parolen aus den Siebzigerjahren (»Atom­kraft – nein danke!«) und Vogel-Strauß-Politik verspielen wir unsere Zukunft als Industrienation. Konrad Kleinknecht zeigt, wie alarmierend die Situation ist. Schon bald wird die Klimaänderung dazu führen, dass Millionen Menschen nach Europa kommen, weil ihre Lebensräume unbewohnbar geworden sind, schon bald wird Energie, der Lebenssaft unserer Zivilisation, nicht mehr ausreichend verfügbar oder bezahlbar sein. Als Physiker kann Kleinknecht klar nachweisen, dass der bisherige Energiekurs, das Setzen auf fossile Energien, in den Untergang führt.

  5. List of Participants

    Science.gov (United States)

    2007-11-01

    Mohab Abou ZeidVrije Universiteit, Brussel Joke AdamKatholieke Universiteit Leuven Nikolas AkerblomMax-Planck-Institut für Physik, München Luis Fernando Alday Utrecht University Stelios Alexandris University of Patras Antonio Amariti Università di Milano-Bicocca Nicola Ambrosetti Université de Neuchâtel Pascal Anastasopoulos Università di Roma Tor Vergata Laura Andrianopoli Enrico Fermi Center Carlo Angelantonj Università di Torino Lilia Anguelova Queen Mary, University of London Daniel AreanUniversidade de Santiago de Compostela Gleb ArutyunovUtrecht University Spyros Avramis NTU Athens—University of Patras Ioannis Bakas University of Patras Subrata Bal Dublin Institute for Advanced Studies Igor Bandos Valencia University Jessica Barrett University of Iceland Marco Baumgartl Eidgenössische Technische Hochschule, Zürich Jacopo Bechi Università di Firenze James Bedford Queen Mary, University of London Jorge Bellorin Universidad Autonoma de Madrid Francesco Benini SISSA, Trieste Eric Bergshoeff Centre for Theoretical Physics, University of Groningen Gaetano BertoldiUniversity of Wales, Swansea Adel Bilal Laboratoire de Physique Théorique, École Normale Superieure, Paris Matthias Blau Université de Neuchâtel Johannes BroedelUniversität Hannover Felix Brümmer Universität Heidelberg Julio Cesar Bueno de Andrade São Paulo State University—UNESP Cliff Burgess McMaster University Agostino Butti Laboratoire de Physique Théorique, École Normale Superieure, Paris Marco Caldarelli Universitat de Barcelona Pablo G Camara Centre de Physique Théorique, École Polytechnique, Palaiseau Joan Camps Universitat de Barcelona Felipe Canoura FernandezUniversidade de Santiago de Compostela Luigi Cappiello Università di Napoli Federico II Luca Carlevaro École Polytechnique, Palaiseau Roberto Casero Centre de Physique Théorique, École Polytechnique, Palaiseau Claudio Caviezel Max-Planck-Institut für Physik, München Alessio Celi Universitat de Barcelona Anna

  6. Development of a multi-electrode extrapolation chamber as a prototype of a primary standard for the realization of the unit of the absorbed dose to water for beta brachytherapy sources

    CERN Document Server

    Bambynek, M

    2002-01-01

    The prototype of a primary standard has been developed, built and tested, which enables the realization of the unit of the absorbed dose to water for beta brachytherapy sources. In the course of the development of the prototype, the recommendations of the American Association of Physicists in Medicine (AAPM) Task Group 60 (TG60) and the Deutsche Gesellschaft fuer Medizinische Physik (DGMP) Arbeitskreis 18 (AK18) were taken into account. The prototype is based on a new multi-electrode extrapolation chamber (MEC) which meets, in particular, the requirements on high spatial resolution and small uncertainty. The central part of the MEC is a segmented collecting electrode which was manufactured in the clean room center of PTB by means of electron beam lithography on a wafer. A precise displacement device consisting of three piezoelectric macrotranslators has been incorporated to move the wafer collecting electrode against the entrance window. For adjustment of the wafer collecting electrode parallel to the entranc...

  7. Quantenmechanik verstehen eine Einführung in den Welle-Teilchen-Dualismus für Lehrer und Studierende

    CERN Document Server

    Pietschmann, Herbert

    2003-01-01

    Der bekannte Autor H. Pietschmann wendet sich mit diesem Buch an Physiklehrer an höheren Schulen und an Physikstudenten im Anschluß an deren Grundausbildung. Quantenmechanik entzieht sich der Anschaulichkeit, wie wir sie von der klassischen Physik her kennen, aber - und das ist das Kernthema des Buchs - man kann sie sehr wohl verstehen. H. Pietschmann gelingt es, dies mit einfachen Mitteln zu erreichen, und damit gibt er Lehrerinnen und Lehrern eine Unterrichtshilfe und Studenten eine Einführung in die anspruchsvollen Hochschultexte an die Hand. Die mathematische Behandlung spielt keine zentrale Rolle, vielmehr wird versucht, der Interpretation und dem Denken in quantenmechanischen Kategorien breiten Raum zu geben. Behandelt werden z.B. die Quantenhypothese unter Einbeziehung der Geschichte dieses Konzepts, die Schrödingertheorie, die Interpretation der Wellenfunktion und der Messprozess, die Ein- und Mehrelektronenatome sowie Fragen der Zeitabhängigkeit.

  8. Otázka slobodnej vôle v helenistickej filozofii (na pozadí Ciceronovho spisu De fato (Die Frage des freien Willens in der hellenistischen Philosophie (In Anbetracht der Ciceros Schrift De fato

    Directory of Open Access Journals (Sweden)

    Peter Fraňo

    2010-06-01

    Full Text Available In diesem Beitrag ich beschäftige mich mit der Frage: Ist das menschliche handeln vorbestimmt, oder kann der Einzelne frei entscheiden? Diese problematik wurde in der hellenistischen Philosophie sehr verbreitet. Das erste mal hat diese Frage Aristoteles in seinen Werken: Die Nikomachische Etik und vor allem De Interpretatione erforscht, wo hat sich die logische Problematik des sogenannten περὶ δυνατῶν berührt. Die megarischen Philosophen Diodoros Kronos und Philon von Megara hat auf die Lösung des Aristoteles reagiert. Außer der Logik ist die Problematik des freien Willes der Bestandteil der stoischen Physik (Astrologie, Sympathie uns stoische Ursachen gewesen. In meinem Beitrag ich habe auf diese Gesichtspunkte in Anbetracht der Ciceros Schrift De fato hingewiesen.

  9. Excimer laser processing of inkjet-printed and sputter-deposited transparent conducting SnO2:Sb for flexible electronics

    International Nuclear Information System (INIS)

    Cranton, Wayne M.; Wilson, Sharron L.; Ranson, Robert; Koutsogeorgis, Demosthenes C.; Chi Kuangnan; Hedgley, Richard; Scott, John; Lipiec, Stephen; Spiller, Andrew; Speakman, Stuart

    2007-01-01

    The feasibility of low-temperature fabrication of transparent electrode elements from thin films of antimony-doped tin oxide (SnO 2 :Sb, ATO) has been investigated via inkjet printing, rf magnetron sputtering and post-deposition excimer laser processing. Laser processing of thin films on both glass and plastic substrates was performed using a Lambda Physik 305i excimer laser, with fluences in the range 20-100 mJ cm -2 reducing sheet resistance from as-deposited values by up to 3 orders of magnitude. This is consistent with TEM analysis of the films that shows a densification of the upper 200 nm of laser-processed regions

  10. A collection of problems for physics teaching

    International Nuclear Information System (INIS)

    Groeber, S; Jodl, H-J

    2010-01-01

    Problems are an important instrument for teachers to mediate physics content and for learners to adopt this content. This collection of problems is not only suited to traditional teaching and learning in lectures or student labs, but also to all kinds of new ways of teaching and learning, such as self-study, long-distance teaching, project-oriented learning and the use of remote labs/web experiments. We focus on Rutherford's scattering experiment, electron diffraction, Millikan's experiment and the use of pendulums to measure the dependence of gravitational acceleration on latitude. The collection contains about 50 problems with 160 subtasks and solutions, altogether 100 pages. Structure, content, range and the added value of the problems are described. The whole collection can be downloaded for free from http://rcl.physik.uni-kl.de.

  11. The ethics of physicists in questions

    CERN Multimedia

    2000-01-01

    Four CERN physicists, Peggie Rimmer, Ugo Amaldi, Alain Blondel, and Jean-Marie Le Goff, answered questions from 150 college students last Monday during a debate on the theme of the ethics of physics. Organized by CERN and the Department of public instruction of the Canton of Geneva, the meeting followed a reading by the students of the play Die Physiker, by Friedrich Dürrenmatt, which raises the problem of political exploitation of discoveries made during the second world war. The Minister of Education of the Canton de Genève, Mrs Martine Brunschwig-Graf, took part in the debate. The questions posed by students were not lacking in pertinence : Should a physicist reveal a discovery that is dangerous in his opinion ? Who are responsible, those who make the discoveries or those who use them ?

  12. Mathematical analysis and numerical methods for science and technology

    CERN Document Server

    Dautray, Robert

    These 6 volumes - the result of a 10 year collaboration between the authors, two of France's leading scientists and both distinguished international figures - compile the mathematical knowledge required by researchers in mechanics, physics, engineering, chemistry and other branches of application of mathematics for the theoretical and numerical resolution of physical models on computers. Since the publication in 1924 of the "Methoden der mathematischen Physik" by Courant and Hilbert, there has been no other comprehensive and up-to-date publication presenting the mathematical tools needed in applications of mathematics in directly implementable form. The advent of large computers has in the meantime revolutionised methods of computation and made this gap in the literature intolerable: the objective of the present work is to fill just this gap. Many phenomena in physical mathematics may be modeled by a system of partial differential equations in distributed systems: a model here means a set of equations, which ...

  13. Measurement of the total cross section difference {Delta}{sigma}{sub L} in np transmission at 1.19, 2.49 and 3.65 GeV

    Energy Technology Data Exchange (ETDEWEB)

    Averichev, S.A. [Joint Inst. for Nuclear Research, Dubna (Russian Federation). Lab. of High Energy; Azhgirey, L.S. [Joint Inst. for Nuclear Research, Dubna (Russian Federation). Lab. of Nuclear Problems; Benda, B. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee; Adiasevich, B.P. [Russian Research Centre Kurchatov Inst., Moscow (Russian Federation); Ball, J. [Laboratoire National Saturne - Centre d`Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France); Bazhanov, N.A. [AN SSSR, Leningrad (Russian Federation). Inst. Yadernoj Fiziki; Dzyubak, A.P. [AN Ukrainskoj SSR, Kharkov (Ukraine). Fiziko-Tekhnicheskij Inst.; Fedorov, A.N. [Joint Inst. for Nuclear Research, Dubna (Russian Federation). Lab. of Particle Physics; Grosnick, D.P. [Argonne National Lab., IL (United States). High Energy Physics Div.; Gurevich, G.M. [AN SSSR, Moscow (Russian Federation). Inst. Yadernykh Issledovanij] [and others

    1996-01-01

    Results of the total cross section difference {Delta}{sigma}{sub L} in a np transmission experiment are presented. Results were obtained with a polarized beam of free quasi-monochromatic neutrons passing through the new Dubna frozen spin proton target. The beam and target polarizations were oriented longitudinally. The new results are compared with {Delta}{sigma}{sub L}(pn) data determined as a difference between {Delta}{sigma}{sub L}(pd) and {Delta}{sigma}{sub L}(pp) ANL-ZGS measurements. The values of {Delta}{sigma}{sub L} for the isospin state I=0 were deduced using known pp data. (author). Submitted to Zeitschrift fuer Physik, C (DE); 51 refs.

  14. The new tyre book. New trends - technical aspects - driving characteristics - buyer's guide; Das neue Reifenbuch. Umruestung - Reifentechnik - Fahrpraxis - Kaufberatung

    Energy Technology Data Exchange (ETDEWEB)

    Backfisch, K.P.; Heinz, D.S.

    2000-07-01

    Contents: Test methods of the tyre industry and acceptance tests; Differences between winter tyres, summer tyres and four-season tyres; Quality characteristics; Conversion to broad tyres; Tyre wall lettering; light metal wheels and tyre maintenance. There is a chapter on car driving viewed as applied physics, and the book contains hints on tyre handling as well as information on current and future trends on the tyre market. [German] Berichtet wird ueber Testverfahren der Reifenindustrie und die Verfahren zur Erstausruestungsfreigabe bei den Automobilherstellern. Das Buch informiert ueber die Unterschiede zwischen Sommer-, Winter- und Ganzjahresreifen, ueber Qualitaetsmerkmale, Umruestung auf Breitreifen oder die Seitenwandbeschriftung eines Reifens, zudem ueber Leichtmetallraeder und Reifenpflege. Autofahren ist angewandte Physik, diesem Aspekt widmet sich ein ganzes Kapitel. Der Leser erhaelt wichtige Tips zum Umgang mit Reifen sowie Informationen ueber aktuelle und kuenftige Entwicklungen auf dem Reifenmarkt. (orig.)

  15. Supraleitung Grundlagen und Anwendungen

    CERN Document Server

    Buckel, Werner

    2004-01-01

    Seit nunmehr drei Jahrzehnten ist der "Buckel" das Referenzwerk in deutscher Sprache zum Thema Supraleitung. Immer wieder aktualisiert, hat das Lehrbuch Generationen von Studenten begleitet. In der 6., vollständig überarbeiteten Auflage wird das bewährte didaktische Konzept beibehalten, inhaltlich wurde der Band dem aktuellen Stand von Forschung und Technik angepasst. Das Autorenteam um Prof. Kleiner verzichtet auf komplizierte mathematische Herleitungen. Es baut ganz auf das bewährte Step-by-Step-Prinzip: Der Schwierigkeitsgrad wird von Kapitel zu Kapitel gesteigert. So können auch Einsteiger ohne einschlägige Vorkenntnisse dem Stoff bequem folgen. Dank seiner klaren Sprache und zahlreicher Abbildungen eignet sich der Band hervorragend als einführendes Lehrbuch - und zwar nicht nur für Physik-Studenten, sondern auch für Studierende angrenzender Natur- und Ingenieurwissenschaften. Grundlegende Eigenschaften, supraleitende Elemente, Cooper-Paarung, Thermodynamik, kritische Ströme, Josephsonkontakte...

  16. Nano-physics and bio-electronics a new odyssey

    CERN Document Server

    Chakraborty, T; Sivan, U

    2002-01-01

    This book is a collection of some of the invited talks presented at the international meeting held at the Max Planck Institut fuer Physik Komplexer Systeme, Dresden, Germany during August 6-30, 2001, on the rapidly developing field of nanoscale science in science and bio-electronics Semiconductor physics has experienced unprecedented developments over the second half of the twentieth century. The exponential growth in microelectronic processing power and the size of dynamic memorie has been achieved by significant downscaling of the minimum feature size. Smaller feature sizes result in increased functional density, faster speed, and lower costs. In this process one is reaching the limits where quantum effects and fluctuations are beginning to play an important role. This book reflects the achievements of the present times and future directions of research on nanoscopic dimensions.

  17. Rückwärtsintegration - Zu den Verhältnissen Gymnasium, Hochschule und Arbeitswelt

    Science.gov (United States)

    Schmid, Gerhard; Heppner, Winfried; Focht, Eva

    In seiner 2007 erschienen Sammlung von Vorträgen und Essays beschäftigt sich Wolfgang Frühwald, mit der Frage "Wieviel Wissen brauchen wir?“ [1] Die Kernproblematik moderner Wissenschaft und Forschung sieht der Autor, emeritierter Ordinarius für Neuere Deutsche Literaturwissenschaft und von 1992 bis 1997 Präsident der Deutschen Forschungsgemeinschaft, einerseits in der zunehmenden Spezialisierung der Wissenschaftsbereiche, andererseits in der Gefahr der Abkoppelung der Naturwissenschaften von den Geisteswissenschaften. Wiederholt plädiert er dafür, über der rasanten Entwicklung beispielsweise in der Biologie und Physik, die historische, gesellschaftliche und besonders die ethische Dimension der Forschung nicht zu übersehen und fordert eine übergeordnete Theorie der Wissenschaft, die nur im Dialog zwischen den einzelnen Fachgebieten zu entwickeln sei.

  18. Zum Wissenschaftsverständnis der modernen Evolutionsbiologie

    Science.gov (United States)

    Sommer, Ralf J.

    Die moderne Evolutionsbiologie hat ihren Ursprung in den Arbeiten von Charles Darwin und Alfred Wallace (Darwin 1963). Der gemeinsame Ausgangspunkt des Evolutionsgedanken ist dabei die Beobachtung, dass die biologische Welt nicht konstant ist. Biologische Systeme und alle darin lebenden Organismen unterliegen über längere Zeiträume hinweg einer stetigen Veränderung. Diese grundlegende Eigenschaft biologischer Systeme macht die Biologie zu einer historischen Wissenschaft und stellt einen wichtigen Gegensatz zu großen Teilen der Physik dar. Obwohl die Aussage von der Veränderlichkeit der Arten heute trivial klingt, war sie im 19. Jahrhundert eine Revolution, da die Konstanz der Arten und der Welt eine vorherrschende Stellung im damaligen Weltbild hatte (Amundson 2005).

  19. The neutron lifetime experiment PENeLOPE

    Energy Technology Data Exchange (ETDEWEB)

    Schreyer, Wolfgang [Technische Universitaet Muenchen (Germany); Collaboration: PENeLOPE-Collaboration

    2015-07-01

    The neutron lifetime τ{sub n}=880.3±1.1 s is an important parameter in the Standard Model of particle physics and in Big Bang cosmology. Several systematic corrections of previously published results reduced the PDG world average by several σ in the last years and call for a new experiment with complementary systematics. The experiment PENeLOPE, currently under construction at the Physik-Department of Technische Universitaet Muenchen, aims to determine the neutron lifetime with a precision of 0.1 s. It will trap ultra-cold neutrons in a magneto-gravitational trap using a large superconducting magnet and will measure their lifetime by both neutron counting and online proton detection. This presentation gives an overview over the latest developments of the experiment.

  20. MSCAP [Magnet System Circuitry Analysis Program] simulations of TESPE magnet safety transients

    International Nuclear Information System (INIS)

    Herring, J.S.; Juengst, K.P.; Jones, J.L.; Kraus, H.G.

    1988-01-01

    During 1987, a series of tests were carried out on the TESPE Facility at the Institut fuer Technische Physik of the Kernforschungszentrum Karlsruhe in conjunction with the Idaho National Engineering Laboratory (INEL) to experimentally and analytically investigate arcing phenomena in high field superconducting magnets. One objective of the tests was to verify computer code simulations of the magnet system. TESPE is a six coil, NbTi, toroidal magnet set, designed to operate with 7 T and 8.3 MJ at 7000 A. The full TESPE circuit was modeled for four series of experiments: internal shorts during charge and discharge, arcs initiated by electrode separation, arcs initiated by a vaporizing wire, and arcs moving along two rails. 3 refs., 15 figs., 1 tab

  1. The concept of intelligibility in modern physics (1948).

    Science.gov (United States)

    Feyerabend, Paul K

    2016-06-01

    This is an English translation of Paul Feyerabend's earliest extant essay "Der Begriff der Verständlichkeit in der modernen Physik" (1948). In it, Feyerabend defends positivism as a progressive framework for scientific research in certain stages of scientific development. He argues that in physics visualizability (Anschaulichkeit) and intelligibility (Verständlichkeit) are time-conditioned concepts: what is deemed visualizable in the development of physical theories is relative to a specific historical context and changes over time. He concludes that from time to time the abandonment of visualizability is crucial for progress in physics, as it is conducive to major theory change, illustrating the point on the basis of advances in atomic theory. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. A survey of the urban radiofrequency (RF) environment

    International Nuclear Information System (INIS)

    Tell, Richard A.; Kavet, Robert

    2014-01-01

    In 1980, Tell and Mantiply published a study of radiofrequency (RF) fields measured across 15 major metropolitan areas in the USA. They required a van fully equipped with instrumentation and computing capability for their measurements. This study aimed to assess whether and how hand-held instrumentation available today would facilitate and enhance the efficiency of large-scale surveys of ambient RF fields. In addition, the data would provide a suggestion as to how the profile of ambient RF fields has changed with respect to frequency content and magnitude. Not unexpectedly, the relative power densities were orders of magnitude lower than the Federal Communications Commission's (FCC) maximum permissible exposure (MPE) for the general public, with a maximum time-averaged value across the VHF-FM-UHF-cellular bands of 0.12 % of the MPE (AM's contribution was negligible). In both the 1980 and the present study, the power density in the FM band was a major contributor to overall power density, but over time, power densities in the VHF and UHF band decreased and increased, respectively. From the perspective of absolute power density, the wideband values in the 1980 study, this study and any number of assessments conducted in European nations are not generally different from one another. (authors)

  3. EUTEMPE-RX, an EC supported FP7 project for the training and education of medical physics experts in radiology

    International Nuclear Information System (INIS)

    Bosmans, H.; Van Peteghem, N.; Bliznakova, K.; Vassileva, J.; Padovani, R.; Christofides, S.; Tsapaki, V.; Caruana, C.J.

    2015-01-01

    The core activity of the medical physics expert (MPE) is to ensure optimal use of ionising radiation in health care. It is essential that these health care professionals are trained to the highest level, defined as European Qualifications Framework for Lifelong Learning (EQF) level 8 by the European Commission's Radiation Protection Report 174 'Guidelines on the MPE'. The main objective of the EUTEMPE-RX project is to provide a model training scheme that allows the medical physicist in diagnostic and interventional radiology (D and IR) to reach this high level. A European network of partners was brought together in this FP7 EC project to ensure sufficient expertise in all aspects of the subject and to create a harmonised course programme. Targeted participants are medical physicists in D and IR in hospitals, engineers and scientists in medical device industries and officers working in regulatory authorities. Twelve course modules will be developed at EQF level 8, with radiation safety and diagnostic effectiveness being prevalent subjects. The modules will combine online with face-to-face teaching using a blended learning approach. (authors)

  4. Effect of NiO inserted layer on spin-Hall magnetoresistance in Pt/NiO/YIG heterostructures

    International Nuclear Information System (INIS)

    Shang, T.; Zhan, Q. F.; Yang, H. L.; Zuo, Z. H.; Xie, Y. L.; Liu, L. P.; Zhang, S. L.; Zhang, Y.; Li, H. H.; Wang, B. M.; Li, Run-Wei; Wu, Y. H.; Zhang, S.

    2016-01-01

    We investigate spin-current transport with an antiferromagnetic insulator NiO thin layer by means of the spin-Hall magnetoresistance (SMR) over a wide range of temperature in Pt/NiO/Y_3Fe_5O_1_2 (Pt/NiO/YIG) heterostructures. The SMR signal is comparable to that without the NiO layer as long as the temperature is near or above the blocking temperature of the NiO, indicating that the magnetic fluctuation of the insulating NiO is essential for transmitting the spin current from the Pt to YIG layer. On the other hand, the SMR signal becomes negligibly small at low temperature, and both conventional anisotropic magnetoresistance and the anomalous Hall resistance are extremely small at any temperature, implying that the insertion of the NiO has completely suppressed the Pt magnetization induced by the YIG magnetic proximity effect (MPE). The dual roles of the thin NiO layer are, to suppress the magnetic interaction or MPE between Pt and YIG, and to maintain efficient spin current transmission at high temperature.

  5. Rancang Bangun Transportasi Logistik Kakao Agroindustri Coklat Kabupaten Pidie Jaya Provinsi Aceh

    Directory of Open Access Journals (Sweden)

    Yusriana Yusriana

    2013-02-01

    Full Text Available Factual problems of the cocoa bean agroindustry at Pidie Jaya District, Aceh Province were large distances between farmers and processor, thus determining the shortest part route, backhaul location and quality risk becomes critically to the assess. The objective this research are to determine shortest route based on the location of suppliers, back location, and risk quality recommendations. Requirement of shortest part route solved by Algorithm Djisktra, Backhaul location with MPE and Risk management quality by Multi Expert Multi Criteria Decision Making, aggregation criteria with OWA. The result of the study shows that the shortest distance suppliers Aceh Timur District was 282km, Aceh Utara District 116km, Bireuen District 57km, Pidie District 24km and Aceh Tenggara District 391km. Backhaul location sat Aceh Tengah District with a value of MPE(6533. Alternative of quality risk management were direct fermentation, improvement of transport facilities and container with a high rating criteria, thus the agroindustry has to focus on this dimension.

  6. News regarding Mobility at CERN

    CERN Multimedia

    2016-01-01

    CERN Bikes CERN owns a fleet of more than 500 bikes, managed by the Mobility Centre (bdg. 6167). Members of CERN personnel (MPE and MPA) can use these free of charge during work-related activities at CERN (a security deposit is requested). Between 1st of June to 30th September anyone, except Summer Students, who wish to benefit from this service shall pay 1 CHF per day. As from the 1st of August, the CERN bike rental requests are done via the Service Now (SNOW) Portal. For more information, please consult: http://cern.ch/bike-rental.   CERN Cars More than 60 vehicles are available for rent by members of personnel (MPE and MPA) at the Mobility Center (bdg. 6167). As from the 5th of September you can submit reservation requests via the new EDH Car Rental Request document. As a reminder, the Terms of Use are the following: Operational Circular n° 4 (rev.1), governing the use of CERN vehicles;   Any use of the service must be authorised by the concerned Head of Department or Team Leader...

  7. Detection of EpCAM-positive microparticles in pleural fluid: A new approach to mini-invasively identify patients with malignant pleural effusions.

    Science.gov (United States)

    Roca, Elisa; Lacroix, Romaric; Judicone, Coralie; Laroumagne, Sophie; Robert, Stéphane; Cointe, Sylvie; Muller, Alexandre; Kaspi, Elise; Roll, Patrice; Brisson, Alain R; Tantucci, Claudio; Astoul, Philippe; Dignat-George, Françoise

    2016-01-19

    Pleural biomarkers allowing to mini-invasively discriminate benign from malignant pleural effusions are needed. Among potential candidates, microparticles (MPs) are extracellular vesicles that vectorize antigen derived from the parent cell. We hypothesized that tumor-derived MPs could be present in the pleural liquid and help to identify patients with malignant pleural effusions. Using highly sensitive flow cytometry and cryo-electron microscopy, we showed that large amounts of MPs from hematopoïetic and vascular origin could be detectable in pleural fluids. Their level did not differ between benign (n = 14) and malignant (n = 71) pleural effusions. Analysis of selected tumoral associated antigens (podoplanin, mucin 1 and EpCAM, epithelial-cell-adhesion-molecule) evidenced for the first time the presence of tumor-derived MPs expressing EpCAM in malignant pleural fluids only (Specificity = 93%, Sensitivity = 49% and 45% for flow cytometry and ELISA, respectively). The detection of EpCAM-positive-MPs (EpCAM + MPs) by flow cytometry showed a better specificity and sensitivity than ELISA to distinguish between pleural carcinoma and the others malignant pleural effusions (MPE; Sp: 96% vs 89%; Se: 79% vs 66%). Combining EpCAM+ MPs and cytology improved the diagnosis of MPE compared to cytology alone. This study establishes the basis for using EpCAM+ MPs as a promising new biomarker that could be added to the armamentarium to mini-invasively identify patients with malignant pleural effusions.

  8. Environmental assessment of garden waste management in the Municipality of Aarhus, Denmark

    International Nuclear Information System (INIS)

    Boldrin, Alessio; Andersen, Jacob K.; Christensen, Thomas H.

    2011-01-01

    An environmental assessment of six scenarios for handling of garden waste in the Municipality of Aarhus (Denmark) was performed from a life cycle perspective by means of the LCA-model EASEWASTE. In the first (baseline) scenario, the current garden waste management system based on windrow composting was assessed, while in the other five scenarios alternative solutions including incineration and home composting of fractions of the garden waste were evaluated. The environmental profile (normalised to Person Equivalent, PE) of the current garden waste management in Aarhus is in the order of -6 to 8 mPE Mg -1 ww for the non-toxic categories and up to 100 mPE Mg -1 ww for the toxic categories. The potential impacts on non-toxic categories are much smaller than what is found for other fractions of municipal solid waste. Incineration (up to 35% of the garden waste) and home composting (up to 18% of the garden waste) seem from an environmental point of view suitable for diverting waste away from the composting facility in order to increase its capacity. In particular the incineration of woody parts of the garden waste improved the environmental profile of the garden waste management significantly.

  9. Trends in nanosecond melanosome microcavitation up to 1540 nm

    Science.gov (United States)

    Schmidt, Morgan S.; Kennedy, Paul K.; Noojin, Gary D.; Vincelette, Rebecca L.; Thomas, Robert J.; Rockwell, Benjamin A.

    2015-09-01

    Thresholds for microcavitation of bovine and porcine melanosomes were previously reported, using single nanosecond (ns) laser pulses in the visible (532 nm) and the near-infrared (NIR) from 1000 to 1319 nm. Here, we report average radiant exposure thresholds for bovine melanosome microcavitation at additional NIR wavelengths up to 1540 nm, which range from ˜0.159 J/cm2 at 800 nm to 4.5 J/cm2 at 1540 nm. Melanosome absorption coefficients were also estimated, and decreased with increasing wavelength. These values were compared to retinal pigment epithelium coefficients, and to water absorption, over the same wavelength range. Corneal total intraocular energy retinal damage threshold values were estimated and compared to the previous (2007) and recently changed (2014) maximum permissible exposure (MPE) safe levels. Results provide additional data that support the recent changes to the MPE levels, as well as the first microcavitation data at 1540 nm, a wavelength for which melanosome microcavitation may be an ns-pulse skin damage mechanism.

  10. Infrared laser damage thresholds in corneal tissue phantoms using femtosecond laser pulses

    Science.gov (United States)

    Boretsky, Adam R.; Clary, Joseph E.; Noojin, Gary D.; Rockwell, Benjamin A.

    2018-02-01

    Ultrafast lasers have become a fixture in many biomedical, industrial, telecommunications, and defense applications in recent years. These sources are capable of generating extremely high peak power that can cause laser-induced tissue breakdown through the formation of a plasma upon exposure. Despite the increasing prevalence of such lasers, current safety standards (ANSI Z136.1-2014) do not include maximum permissible exposure (MPE) values for the cornea with pulse durations less than one nanosecond. This study was designed to measure damage thresholds in corneal tissue phantoms in the near-infrared and mid-infrared to identify the wavelength dependence of laser damage thresholds from 1200-2500 nm. A high-energy regenerative amplifier and optical parametric amplifier outputting 100 femtosecond pulses with pulse energies up to 2 mJ were used to perform exposures and determine damage thresholds in transparent collagen gel tissue phantoms. Three-dimensional imaging, primarily optical coherence tomography, was used to evaluate tissue phantoms following exposure to determine ablation characteristics at the surface and within the bulk material. The determination of laser damage thresholds in the near-IR and mid-IR for ultrafast lasers will help to guide safety standards and establish the appropriate MPE levels for exposure sensitive ocular tissue such as the cornea. These data will help promote the safe use of ultrafast lasers for a wide range of applications.

  11. MICROS E PEQUENAS EMPRESAS NO BRASIL – UM OLHAR PARA SITUAÇÃO EM OSASCO E UMA CONTRIBUIÇÃO PARA O PROCESSO DE IMPLANTAÇÃO DO CÓDIGO DE ÉTICA

    Directory of Open Access Journals (Sweden)

    Maria Inês Zampolim Coelho

    2011-06-01

    Full Text Available The organic structure of Micro and Small Companies (MPE in Brazil is simpler than the one in medium and large companies, nevertheless they can present similar problems in its day-today, such as ethical misconduct of its administrators or owners, controllers’ or employees’ corruption, fiscal tax evasion, problems of relationships with customers and suppliers, among others conflicts. The main objective of this research is identifying the current situation of some of the smaller companies in the city of Osasco, focusing on the Code of Ethics. The research sample, made through phone calls, showed us that many of these companies do not have any code of ethics. This finding indicated the necessity for a bibliographical research and some statistical data to confirm the importance of the Ethic Code for the MPE. The results gave us the opportunity to contribute with steps for the implementation of an Ethic Code in Micro and Small companies, aiming an expansion of their market image and better competitiveness.

  12. Sensitivity of Distributed Hydrologic Simulations to Ground and Satellite Based Rainfall Products

    Directory of Open Access Journals (Sweden)

    Singaiah Chintalapudi

    2014-05-01

    Full Text Available In this study, seven precipitation products (rain gauges, NEXRAD MPE, PERSIANN 0.25 degree, PERSIANN CCS-3hr, PERSIANN CCS-1hr, TRMM 3B42V7, and CMORPH were used to force a physically-based distributed hydrologic model. The model was driven by these products to simulate the hydrologic response of a 1232 km2 watershed in the Guadalupe River basin, Texas. Storm events in 2007 were used to analyze the precipitation products. Comparison with rain gauge observations reveals that there were significant biases in the satellite rainfall products and large variations in the estimated amounts. The radar basin average precipitation compared very well with the rain gauge product while the gauge-adjusted TRMM 3B42V7 precipitation compared best with observed rainfall among all satellite precipitation products. The NEXRAD MPE simulated streamflows matched the observed ones the best yielding the highest Nash-Sutcliffe Efficiency correlation coefficient values for both the July and August 2007 events. Simulations driven by TRMM 3B42V7 matched the observed streamflow better than other satellite products for both events. The PERSIANN coarse resolution product yielded better runoff results than the higher resolution product. The study reveals that satellite rainfall products are viable alternatives when rain gauge or ground radar observations are sparse or non-existent.

  13. Using Akka Platform in Unidentified Falling Object Detection on the LHC.

    CERN Document Server

    Motesnitsalis, Evangelos

    2013-01-01

    During my participation in the CERN Summer Student Program 2013, I worked under the Technology Department of CERN and, more specifically, in the Machine Protection and Electrical Integrity (MPE) Group. The MPE Group supports LHC operation and maintains state‐of‐the art technology for magnet circuit protection and interlock systems for the present and future accelerators, magnet test facilities and CERN hosted experiments. Within this context, we developed an application that parallelizes the Unidentified Falling Object Detection Algorithm on the LHC Operational Data Analysis Software. For this reason, we used a JVM-based toolkit, named Akka, which parallelizes the execution by creating a number of actors that run simultaneously. The results of the new approach are presented on the last part of this report. They tend to be quite interesting and promising as we managed to reduce the execution time of the analysis by a factor of 10 on a local machine and the first attempts to execute the program on a cluster...

  14. On the Latent Variable Interpretation in Sum-Product Networks.

    Science.gov (United States)

    Peharz, Robert; Gens, Robert; Pernkopf, Franz; Domingos, Pedro

    2017-10-01

    One of the central themes in Sum-Product networks (SPNs) is the interpretation of sum nodes as marginalized latent variables (LVs). This interpretation yields an increased syntactic or semantic structure, allows the application of the EM algorithm and to efficiently perform MPE inference. In literature, the LV interpretation was justified by explicitly introducing the indicator variables corresponding to the LVs' states. However, as pointed out in this paper, this approach is in conflict with the completeness condition in SPNs and does not fully specify the probabilistic model. We propose a remedy for this problem by modifying the original approach for introducing the LVs, which we call SPN augmentation. We discuss conditional independencies in augmented SPNs, formally establish the probabilistic interpretation of the sum-weights and give an interpretation of augmented SPNs as Bayesian networks. Based on these results, we find a sound derivation of the EM algorithm for SPNs. Furthermore, the Viterbi-style algorithm for MPE proposed in literature was never proven to be correct. We show that this is indeed a correct algorithm, when applied to selective SPNs, and in particular when applied to augmented SPNs. Our theoretical results are confirmed in experiments on synthetic data and 103 real-world datasets.

  15. Elections for representatives of the personnel – Join, get involved, vote!

    CERN Multimedia

    Staff Association

    2017-01-01

    Every two years in September, the CERN Staff Association organises the elections of representatives of the personnel. The process of renewing the Staff Council consists of several stages: Information for members of the personnel (MPE and MPA1); call for applications and search for candidates in different electoral colleges; election of delegates via electronic voting; announcement of the results and establishing a new Staff Council. This process will follow a specific timetable: Call for applications from Monday, 11 September to Friday, 13 October at 5 p.m. Voting from Monday, 23 October at noon to Monday 13, November at 5 p.m. Publication of the election results in the Echo newsletter on Tuesdays 21 November and 5 December. Staff Association Assizes (for the outgoing Council and the new Council) on Monday, 27 and Tuesday, 28 November. First meeting of the new Staff Council and election of a new Executive Committee on Tuesday, 5 December. Informing the personnel (MPE and MPA) The Staff Association uses s...

  16. Valuación de opciones simples y complejas contenidas en arrendamientos financieros

    Directory of Open Access Journals (Sweden)

    Gastón Silverio Milanesi

    2016-01-01

    Full Text Available El valor de los contratos de arrendamiento es una función del valor presente de los cánones más las opciones reales operativas. Sin embargo, el método del préstamo equivalente (MPE, con amplia aplicación en la valuación de arrendamientos, falla porque no incorpora las opciones contenidas en el contrato. De esta forma, el presente trabajo propone un modelo de valuación combinando el MPE y el enfoque binomial para valuar opciones reales. Para lograr lo anterior, se realiza el planteamiento matemático y su aplicación para opciones simples (compra, cancelación anticipada, renovación y compuestas (venture leasing, leasing a porcentaje, pago diferido, pago diferido y compra, demostrando la habilidad del modelo para calcular el valor actual expandido del contrato, como la suma del valor actual de pagos y opciones operativas.

  17. HPLC Evaluation of Phenolic Profile, Nutritive Content, and Antioxidant Capacity of Extracts Obtained from Punica granatum Fruit Peel

    Science.gov (United States)

    Middha, Sushil Kumar; Usha, Talambedu; Pande, Veena

    2013-01-01

    This study revealed polyphenolic content, nutritive content, antioxidant activity, and phenolic profile of methanol and aqueous extracts of Punica granatum peel extract. For this, extracts were screened for possible antioxidant activities by free radical scavenging activity (DPPH), hydrogen peroxide scavenging activity and ferric-reducing antioxidant power (FRAP) assays. The total phenolics and flavonoid recovered by methanolic (MPE) and the water extract (AQPE) were ranged from 185 ± 12.45 to 298.00 ± 24.86 mg GAE (gallic acid equivalents)/gm and 23.05 ± 1.54 to 49.8 ± 2.14 quercetin (QE) mg/g, respectively. The EC50 of herbal extracts ranged from 100 µg/ml (0.38 quercetin equivalents), for AQPE, 168 µg/ml (0.80 quercetin equivalents), for MPE. The phenolic profile in the methanolic extracts was investigated by chromatographic (HPLC) method. About 5 different flavonoids, phenolic acids, and their derivatives including quercetin (1), rutin (2), gallic acid (3), ellagic acid (4), and punicalagin as a major ellagitannin (5) have been identified. Among both extracts, methanolic extract was the most effective. This report may be the first to show nutritive content and correlation analysis to suggest that phenols and flavonoids might contribute the high antioxidant activity of this fruit peel and establish it as a valuable natural antioxidant source applicable in the health food industry. PMID:23983682

  18. Objective Function and Learning Algorithm for the General Node Fault Situation.

    Science.gov (United States)

    Xiao, Yi; Feng, Rui-Bin; Leung, Chi-Sing; Sum, John

    2016-04-01

    Fault tolerance is one interesting property of artificial neural networks. However, the existing fault models are able to describe limited node fault situations only, such as stuck-at-zero and stuck-at-one. There is no general model that is able to describe a large class of node fault situations. This paper studies the performance of faulty radial basis function (RBF) networks for the general node fault situation. We first propose a general node fault model that is able to describe a large class of node fault situations, such as stuck-at-zero, stuck-at-one, and the stuck-at level being with arbitrary distribution. Afterward, we derive an expression to describe the performance of faulty RBF networks. An objective function is then identified from the formula. With the objective function, a training algorithm for the general node situation is developed. Finally, a mean prediction error (MPE) formula that is able to estimate the test set error of faulty networks is derived. The application of the MPE formula in the selection of basis width is elucidated. Simulation experiments are then performed to demonstrate the effectiveness of the proposed method.

  19. Chronic alcohol drinking: Liver and pancreatic cancer?

    Science.gov (United States)

    Zakhari, Samir

    2015-09-01

    Cancer is a multifactorial disease that results from complex interactions of numerous risk factors - genetic and environmental - over time, eventually leading to the diseased phenotypes. Thus, while epidemiological studies can point to risk factors, they cannot determine cause and effect relationships, and are unable to give biological and clinical insights into carcinogenesis. The link between any risk factor and carcinogenesis needs to be validated in experimental models. This is particularly true in epidemiological studies on alcohol consumption and its consequences. While there is no doubt that heavy alcohol consumption has devastating health effects, the inconsistencies in alcohol-related epidemiological studies and cancer suffer from possible sources of the variability in outcomes, ranging from inaccuracy of self-report of consumption to the problem of correlating cancer that started decades earlier to current or recent alcohol consumption. To further study the interactions between alcohol and cancer, the use of "Molecular Pathological Epidemiology" (MPE) advocated by Ogino et al. for dissecting the interplay between etiological factors, cellular and molecular characteristics, and disease progression in cancer is appropriate. MPE does not consider cancer as a single entity, rather it integrates analyses of epidemiological studies with the macroenvironment and molecular and microenvironment. This approach allows investigating the relationships between potential etiological agents and cancer based on molecular signatures. More research is needed to fully elucidate the link between heavy alcohol consumption and pancreatic cancer, and to further investigate the roles of acetaldehyde and FAEEs in pancreatic carcinogenesis. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  20. SMEs’ Organizational Performance: Comparative Study between Cooperated and Uncooperated Companies

    Directory of Open Access Journals (Sweden)

    Ana Karla de Lucena Justino Gomes

    2017-12-01

    Full Text Available Faced with the need for survival and competitiveness, here called micro and small enterprises (MPE, they seek to develop competitive differentials, such as the insertion of the company into a cooperation network. Several researches seek to identify the benefits of cooperative strategies, but few studies seek to compare the organizational performance of cooperating companies with that of uncooperated companies. Thus, the present study has as general objective to verify if the MPE, when inserted in cooperation networks, present organizational performance superior to those that are not inserted in that context. The present research is of the survey type and involves 67 companies inserted in cooperation networks and 154 companies that do not participate in cooperation networks. To achieve the objective, the organizational performance was analyzed based on the managers' perception regarding aspects associated to the following performance measures: customer satisfaction, employee satisfaction, company growth, company profitability and overall performance. The results indicate that the companies included in cooperation networks presented superior performance when compared to the companies not included in cooperation networks

  1. A Comparative Study of Three Different Chemical Vapor Deposition Techniques of Carbon Nanotube Growth on Diamond Films

    Directory of Open Access Journals (Sweden)

    Betty T. Quinton

    2013-01-01

    Full Text Available This paper compares between the methods of growing carbon nanotubes (CNTs on diamond substrates and evaluates the quality of the CNTs and the interfacial strength. One potential application for these materials is a heat sink/spreader for high-power electronic devices. The CNTs and diamond substrates have a significantly higher specific thermal conductivity than traditional heat sink/spreader materials making them good replacement candidates. Only limited research has been performed on these CNT/diamond structures and their suitability of different growth methods. This study investigates three potential chemical vapor deposition (CVD techniques for growing CNTs on diamond: thermal CVD (T-CVD, microwave plasma-enhanced CVD (MPE-CVD, and floating catalyst thermal CVD (FCT-CVD. Scanning electron microscopy (SEM and high-resolution transmission electron microscopy (TEM were used to analyze the morphology and topology of the CNTs. Raman spectroscopy was used to assess the quality of the CNTs by determining the ID/IG peak intensity ratios. Additionally, the CNT/diamond samples were sonicated for qualitative comparisons of the durability of the CNT forests. T-CVD provided the largest diameter tubes, with catalysts residing mainly at the CNT/diamond interface. The MPE-CVD process yielded non uniform defective CNTs, and FCT-CVD resulted in the smallest diameter CNTs with catalyst particles imbedded throughout the length of the nanotubes.

  2. High IL-35 pleural expression in patients with tuberculous pleural effusion.

    Science.gov (United States)

    Dong, Xuan; Yang, Jiong

    2015-05-03

    IL-35 is a novel anti-inflammatory and immunosuppressive cytokine primarily produced by Treg cells, and is involved in inflammatory diseases and autoimmune diseases. However, its roles in tuberculous pleural effusion (TPE) remain unknown. We aimed to investigate the potential involvement of IL-35 in TPE. Thirty TPE patients and 20 lung cancer patients with malignant pleural effusion (MPE) were recruited. Samples of pleural effusion (100 mL) were collected after traditional pleurocentesis. Blood was sampled from TPE patients. Mononuclear cells were isolated by Ficoll-Hypaque gradient. Proportions of Th1, Th17, and IL-35-producing cells were analyzed by flow cytometry. IL-35 was assessed by real-time RT-PCR, ELISA, and immunofluorescence. An ELISPOT assay was used to assess the effect of IL-35 on pleural effusion mononuclear cells (PEMCs). Proportions of IL-35-producing cells were higher in TPE compared with MPE (49.4±6.0 vs. 15.8±5.4%, Ppleural tissues from TPE patients. Results suggest that there is an imbalance in IL-35 metabolism in TPE. However, further studies are required to assess the exact relationship with the immune system response to tuberculosis. IL-35 might play a role in TPE and might be targeted as a treatment for TPE.

  3. Malignant pleural effusion from papillary thyroid carcinoma diagnosed by pleural effusion cytology: A case report.

    Science.gov (United States)

    Kosmas, Konstantinos; Tsonou, Anna; Mitropoulou, Georgia; Salemi, Eufrosyni; Kazi, Danai; Theofanopoulou, Ageliki

    2018-02-01

    Papillary thyroid carcinoma (PTC) is by far the most common thyroid malignancy (over 85%) of all the thyroid cancers. It has excellent prognosis and 10-year survival rate in most of the cases (95%). Most of the tumors are indolent and do not recur or metastasize after removal. However, widespread metastases to lung, skeleton, central nervous system and, occasionally, other organs may be observed. In rare instances, this disease may metastasize to the pleura and manifest as a malignant pleural effusion (MPE) and portend poor prognosis. This article reports the cytomorphologic and immunocytochemical findings of a female patient with a symptomatic pleural effusion resulting from PTC metastatic to the pleura. Pleural fluid cytology revealed abundant papillary clusters with relatively nuclear pleomorphism, intranuclear cytoplasmic inclusions and nuclear grooves, small and distinct nucleoli as well as small discrete vacuoles. Psammoma bodies were not seen. Immunocytochemical staining was positive for TGB, EMA, Ber-EP4, CK19, and negative for TTF-1. Metastasis of PTC to pleural fluid is extremely rare and diagnosing the disease by cytology is challenging and requires medical expertise as well as knowledge of clinical context and immunocytochemical staining. Additionally, a cytologic diagnosis of MPE due to PTC provides important treatment information and plays an important role in prognosis. © 2017 Wiley Periodicals, Inc.

  4. Reflection of the solar wind ions at the earth's bow shock: energization

    International Nuclear Information System (INIS)

    Bonifazi, C.; Moreno, G.; Russell, C.T.

    1983-01-01

    The energies of the field-aligned proton beams observed upstream of the earth's bow shock are tested, on a statistical basis, against a simple reflection model. The comparison is carried out using both plasma and magnetic field data collected by the ISEE 2 spacecraft. The observations refer to the period from November 5 to December 20, 1977. According to this model, some of the solar wind protons incident upon the earth's shock front when reflected upstream gain energy by displacement parallel to the interplanetary electric field. The energy gained in the reflection can be described as a function of the angles between the interplanetary magnetic field, the solar wind bulk velocity, and the local shock normal. The task of finding these angles, i.e., the expected source point of the reflected ions at the earth's shock front, has been resolved using both the measured magnetic field direction and actual beam trajectory. The latter method, which takes into account the ion drift velocity, leads to a better agreement between theory and observations when far from the shock. In particular, it allows us to check the energies of the field-aligned beams even when they are observed far from the earth's bow shock (at distances up to 10-15 R/sub E/). We confirm, on a statistical basis, the test of the model recently carried out using the Los Alamos National Laboratory/Max-Planck-extraterrestrische observations on ISEE 1 and 2. We infer that reflected beams can sometimes propagate far upstream of the earth's bow shock without changing their energy properties

  5. Comparative Study of the Gross Interpretation of Phototesting and Objective Measurement with Using a Spectrophotometer for Patients with Psoriasis and Vitiligo Treated with Narrow-band UVB.

    Science.gov (United States)

    Choi, Kyu-Won; Kim, Ki-Ho; Kim, Young-Hun

    2009-05-01

    Determination of the minimal erythema dose (MED) is important for developing a phototherapy protocol and to diagnosis photosensitivity disorders. But obtaining a precise and reproducible MED is quite difficult because a phototest for erythema is based on subjective assessment. The objective of our study was to compare the gross interpretation of a phototest and the objective measurement using a spectrophotometer for determining the parameters of cutaneous narrow-band UVB (NBUVB) therapy. A total of 14 psoriasis and 10 vitiligo patients who receiving NBUVB phototherapy with skin types III and IV were selected for this study. To perform phototesting, ten sites on the skin of the back were vertically exposed to a series of 10 NBUVB doses among 14 doses between 340 and 1,400 mJ/cm(2). We interpreted the gross findings of erythema and measured the L*a*b* values with using a spectrophotometer at each phototest spot and at the control skin. Also, we evaluate the relationship between the gross presentation and the spectrophotometric analysis by delta E for the assessment of the minimal perceptible erythema (MPE) and MED. For all the subjects, the MEDs were measured in the 490~1,000 mJ/cm(2) range. The average of the colorimetric values for the control skin were L*: 64.8, a*: 7.9 and b*: 19.8. Among them, the L* value and MED value were shown to be inversely correlated, and as the L* value was decreased, the MED was increased. For the MPE, the delta E, which was the color difference of the normal skin and the phototest area, was within the range of 1.5~3.0 in 17 of the 21 patients, and 4 patients were within the range of 1.0~1.5. For the MED, among the 21 patients, the delta E of 17 patients was within the range of 3.0~6.0, and 4 patients were within the range of 6.0~12.0. A spectrophotometer enables UV erythema to be assessed objectively and quantitatively, and this can compensate for the disadvantages of subjective gross interpretation when determining the MED. Delta E is

  6. A maximum pseudo-likelihood approach for estimating species trees under the coalescent model

    Directory of Open Access Journals (Sweden)

    Edwards Scott V

    2010-10-01

    Full Text Available Abstract Background Several phylogenetic approaches have been developed to estimate species trees from collections of gene trees. However, maximum likelihood approaches for estimating species trees under the coalescent model are limited. Although the likelihood of a species tree under the multispecies coalescent model has already been derived by Rannala and Yang, it can be shown that the maximum likelihood estimate (MLE of the species tree (topology, branch lengths, and population sizes from gene trees under this formula does not exist. In this paper, we develop a pseudo-likelihood function of the species tree to obtain maximum pseudo-likelihood estimates (MPE of species trees, with branch lengths of the species tree in coalescent units. Results We show that the MPE of the species tree is statistically consistent as the number M of genes goes to infinity. In addition, the probability that the MPE of the species tree matches the true species tree converges to 1 at rate O(M -1. The simulation results confirm that the maximum pseudo-likelihood approach is statistically consistent even when the species tree is in the anomaly zone. We applied our method, Maximum Pseudo-likelihood for Estimating Species Trees (MP-EST to a mammal dataset. The four major clades found in the MP-EST tree are consistent with those in the Bayesian concatenation tree. The bootstrap supports for the species tree estimated by the MP-EST method are more reasonable than the posterior probability supports given by the Bayesian concatenation method in reflecting the level of uncertainty in gene trees and controversies over the relationship of four major groups of placental mammals. Conclusions MP-EST can consistently estimate the topology and branch lengths (in coalescent units of the species tree. Although the pseudo-likelihood is derived from coalescent theory, and assumes no gene flow or horizontal gene transfer (HGT, the MP-EST method is robust to a small amount of HGT in the

  7. Radiation protection in dental X-ray surgeries--still rooms for improvement.

    Science.gov (United States)

    Hart, G; Dugdale, M

    2013-03-01

    To illustrate the authors' experience in the provision of radiation protection adviser (RPA)/medical physics expert (MPE) services and critical examination/radiation quality assurance (QA) testing, to demonstrate any continuing variability of the compliance of X-ray sets with existing guidance and of compliance of dental practices with existing legislation. Data was collected from a series of critical examination and routine three-yearly radiation QA tests on 915 intra-oral X-ray sets and 124 panoramic sets. Data are the result of direct measurements on the sets, made using a traceably calibrated Unfors Xi meter. The testing covered the measurement of peak kilovoltage (kVp); filtration; timer accuracy and consistency; X-ray beam size; and radiation output, measured as the entrance surface dose in milliGray (mGy) for intra-oral sets and dose-area product (DAP), measured in mGy.cm(2) for panoramic sets. Physical checks, including mechanical stability, were also included as part of the testing process. The Health and Safety Executive has expressed concern about the poor standards of compliance with the regulations during inspections at dental practices. Thirty-five percent of intra-oral sets exceeded the UK adult diagnostic reference level on at least one setting, as did 61% of those with child dose settings. There is a clear advantage of digital radiography and rectangular collimation in dose terms, with the mean dose from digital sets 59% that of film-based sets and a rectangular collimator 76% that of circular collimators. The data shows the unrealised potential for dose saving in many digital sets and also marked differences in dose between sets. Provision of radiation protection advice to over 150 general dental practitioners raised a number of issues on the design of surgeries with X-ray equipment and critical examination testing. There is also considerable variation in advice given on the need (or lack of need) for room shielding. Where no radiation protection

  8. Summary of: radiation protection in dental X-ray surgeries--still rooms for improvement.

    Science.gov (United States)

    Walker, Anne

    2013-03-01

    To illustrate the authors' experience in the provision of radiation protection adviser (RPA)/medical physics expert (MPE) services and critical examination/radiation quality assurance (QA) testing, to demonstrate any continuing variability of the compliance of X-ray sets with existing guidance and of compliance of dental practices with existing legislation. Data was collected from a series of critical examination and routine three-yearly radiation QA tests on 915 intra-oral X-ray sets and 124 panoramic sets. Data are the result of direct measurements on the sets, made using a traceably calibrated Unfors Xi meter. The testing covered the measurement of peak kilovoltage (kVp); filtration; timer accuracy and consistency; X-ray beam size; and radiation output, measured as the entrance surface dose in milliGray (mGy) for intra-oral sets and dose-area product (DAP), measured in mGy.cm(2) for panoramic sets. Physical checks, including mechanical stability, were also included as part of the testing process. The Health and Safety Executive has expressed concern about the poor standards of compliance with the regulations during inspections at dental practices. Thirty-five percent of intra-oral sets exceeded the UK adult diagnostic reference level on at least one setting, as did 61% of those with child dose settings. There is a clear advantage of digital radiography and rectangular collimation in dose terms, with the mean dose from digital sets 59% that of film-based sets and a rectangular collimator 76% that of circular collimators. The data shows the unrealised potential for dose saving in many digital sets and also marked differences in dose between sets. Provision of radiation protection advice to over 150 general dental practitioners raised a number of issues on the design of surgeries with X-ray equipment and critical examination testing. There is also considerable variation in advice given on the need (or lack of need) for room shielding. Where no radiation protection

  9. Pathways of Prion Spread during Early Chronic Wasting Disease in Deer.

    Science.gov (United States)

    Hoover, Clare E; Davenport, Kristen A; Henderson, Davin M; Denkers, Nathaniel D; Mathiason, Candace K; Soto, Claudio; Zabel, Mark D; Hoover, Edward A

    2017-05-15

    Among prion infections, two scenarios of prion spread are generally observed: (i) early lymphoid tissue replication or (ii) direct neuroinvasion without substantial antecedent lymphoid amplification. In nature, cervids are infected with chronic wasting disease (CWD) prions by oral and nasal mucosal exposure, and studies of early CWD pathogenesis have implicated pharyngeal lymphoid tissue as the earliest sites of prion accumulation. However, knowledge of chronological events in prion spread during early infection remains incomplete. To investigate this knowledge gap in early CWD pathogenesis, we exposed white-tailed deer to CWD prions by mucosal routes and performed serial necropsies to assess PrP CWD tissue distribution by real-time quaking-induced conversion (RT-QuIC) and tyramide signal amplification immunohistochemistry (TSA-IHC). Although PrP CWD was not detected by either method in the initial days (1 and 3) postexposure, we observed PrP CWD seeding activity and follicular immunoreactivity in oropharyngeal lymphoid tissues at 1 and 2 months postexposure (MPE). At 3 MPE, PrP CWD replication had expanded to all systemic lymphoid tissues. By 4 MPE, the PrP CWD burden in all lymphoid tissues had increased and approached levels observed in terminal disease, yet there was no evidence of nervous system invasion. These results indicate the first site of CWD prion entry is in the oropharynx, and the initial phase of prion amplification occurs in the oropharyngeal lymphoid tissues followed by rapid dissemination to systemic lymphoid tissues. This lymphoid replication phase appears to precede neuroinvasion. IMPORTANCE Chronic wasting disease (CWD) is a universally fatal transmissible spongiform encephalopathy affecting cervids, and natural infection occurs through oral and nasal mucosal exposure to infectious prions. Terminal disease is characterized by PrP CWD accumulation in the brain and lymphoid tissues of affected animals. However, the initial sites of prion

  10. Multiscale Persistent Functions for Biomolecular Structure Characterization

    Energy Technology Data Exchange (ETDEWEB)

    Xia, Kelin [Nanyang Technological University (Singapore). Division of Mathematical Sciences, School of Physical, Mathematical Sciences and School of Biological Sciences; Li, Zhiming [Central China Normal University, Wuhan (China). Key Laboratory of Quark and Lepton Physics (MOE) and Institute of Particle Physics; Mu, Lin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Computer Science and Mathematics Division

    2017-11-02

    Here in this paper, we introduce multiscale persistent functions for biomolecular structure characterization. The essential idea is to combine our multiscale rigidity functions (MRFs) with persistent homology analysis, so as to construct a series of multiscale persistent functions, particularly multiscale persistent entropies, for structure characterization. To clarify the fundamental idea of our method, the multiscale persistent entropy (MPE) model is discussed in great detail. Mathematically, unlike the previous persistent entropy (Chintakunta et al. in Pattern Recognit 48(2):391–401, 2015; Merelli et al. in Entropy 17(10):6872–6892, 2015; Rucco et al. in: Proceedings of ECCS 2014, Springer, pp 117–128, 2016), a special resolution parameter is incorporated into our model. Various scales can be achieved by tuning its value. Physically, our MPE can be used in conformational entropy evaluation. More specifically, it is found that our method incorporates in it a natural classification scheme. This is achieved through a density filtration of an MRF built from angular distributions. To further validate our model, a systematical comparison with the traditional entropy evaluation model is done. Additionally, it is found that our model is able to preserve the intrinsic topological features of biomolecular data much better than traditional approaches, particularly for resolutions in the intermediate range. Moreover, by comparing with traditional entropies from various grid sizes, bond angle-based methods and a persistent homology-based support vector machine method (Cang et al. in Mol Based Math Biol 3:140–162, 2015), we find that our MPE method gives the best results in terms of average true positive rate in a classic protein structure classification test. More interestingly, all-alpha and all-beta protein classes can be clearly separated from each other with zero error only in our model. Finally, a special protein structure index (PSI) is proposed, for the first

  11. Prediction of beef carcass and meat traits from rearing factors in young bulls and cull cows.

    Science.gov (United States)

    Soulat, J; Picard, B; Léger, S; Monteils, V

    2016-04-01

    The aim of this study was to predict the beef carcass and LM (thoracis part) characteristics and the sensory properties of the LM from rearing factors applied during the fattening period. Individual data from 995 animals (688 young bulls and 307 cull cows) in 15 experiments were used to establish prediction models. The data concerned rearing factors (13 variables), carcass characteristics (5 variables), LM characteristics (2 variables), and LM sensory properties (3 variables). In this study, 8 prediction models were established: dressing percentage and the proportions of fat tissue and muscle in the carcass to characterize the beef carcass; cross-sectional area of fibers (mean fiber area) and isocitrate dehydrogenase activity to characterize the LM; and, finally, overall tenderness, juiciness, and flavor intensity scores to characterize the LM sensory properties. A random effect was considered in each model: the breed for the prediction models for the carcass and LM characteristics and the trained taste panel for the prediction of the meat sensory properties. To evaluate the quality of prediction models, 3 criteria were measured: robustness, accuracy, and precision. The model was robust when the root mean square errors of prediction of calibration and validation sub-data sets were near to one another. Except for the mean fiber area model, the obtained predicted models were robust. The prediction models were considered to have a high accuracy when the mean prediction error (MPE) was ≤0.10 and to have a high precision when the was the closest to 1. The prediction of the characteristics of the carcass from the rearing factors had a high precision ( > 0.70) and a high prediction accuracy (MPE 0.10). Only the flavor intensity of the beef score could be satisfactorily predicted from the rearing factors with high precision ( = 0.72) and accuracy (MPE = 0.10). All the prediction models displayed different effects of the rearing factors according to animal categories

  12. Co-administration of morphine and gabapentin leads to dose dependent synergistic effects in a rat model of postoperative pain

    DEFF Research Database (Denmark)

    Papathanasiou, Theodoros; Juul, Rasmus Vestergaard; Heegaard, Anne-Marie

    2016-01-01

    dose combinations and investigate whether co-administration leads to synergistic effects in a preclinical model of postoperative pain. The pharmacodynamic effects of morphine (1, 3 and 7 mg/kg), gabapentin (10, 30 and 100 mg/kg) or their combination (9 combinations in total) were evaluated in the rat...... plantar incision model using an electronic von Frey device. The percentage of maximum possible effect (%MPE) and the area under the response curve (AUC) were used for evaluation of the antihyperalgesic effects of the drugs. Identification of synergistic interactions was based on Loewe additivity response...... surface analyses. The combination of morphine and gabapentin resulted in synergistic antihyperalgesic effects in a preclinical model of postoperative pain. The synergistic interactions were found to be dose dependent and the increase in observed response compared to the theoretical additive response...

  13. Marketing practitioner’s tacit knowledge acquisition using Repertory Grid Technique (RTG)

    Science.gov (United States)

    Azmi, Afdhal; Adriman, Ramzi

    2018-05-01

    The tacit knowledge of Marketing practitioner’s experts is excellent resources and priceless. It takes into account their experiential, skill, ideas, belief systems, insight and speculation into management decision-making. This expertise is an individual intuitive judgment and personal shortcuts to complete the work efficiently. Tacit knowledge of Marketing practitioner’s experts is one of best problem solutions in marketing strategy, environmental analysis, product management and partner’s relationship. This paper proposes the acquisition method of tacit knowledge from Marketing practitioner’s using Repertory Grid Technique (RGT). The RGT is a software application for tacit acquisition knowledge to provide a systematic approach to capture and acquire the constructs from an individual. The result shows the understanding of RGT could make TKE and MPE get a good result in capturing and acquiring tacit knowledge of Marketing practitioner’s experts.

  14. The X-ray Telescope for the SWIFT Gamma-Ray Burst Mission

    International Nuclear Information System (INIS)

    Wells, A.; Abbey, A.F.; Beardmore, A.; Mukerjee, K.; Osborne, J.P.; Watson, D.J.; Willingale, R.; Burrows, D. N.; Hill, J. E.; Nousek, J.A.; Miles, B.J.; Mori, K.; Morris, D.C.; Zugger, M.; Chincarini, G.; Campana, S.; Citterio, O.; Moretti, A.; Tagliaferri, G.; Bosworth, J.

    2004-01-01

    The X-ray Telescope (XRT) for the SWIFT mission, built by the international consortium from Pennsylvania State University (United States), University of Leicester (UK) and Osservatorio Astronomico di Brera (Italy), is already installed on the SWIFT spacecraft. The XRT has two key functions on SWIFT; to determine locations of GRBs to better than 5 arc seconds within 100 seconds of initial detection of a burst and to measure spectra and light curves of the X-ray afterglow over around four orders of magnitude of decay in the afterglow intensity. This paper summarises the XRT performance, operating modes and sensitivity for the detection of prompt and extended X-ray afterglows from gamma-ray bursts. The performance characteristics have been determined from data taken during the ground calibration campaign at MPE's Panter facility in September 2002

  15. Uma reflexão sobre a qualificação na formação em turismo: relevancia da micro e pequena empresa para o destino turístico

    OpenAIRE

    Thiago Duarte Pimentel; Sara Conceição de Paula; Marcela Costa Bifano de Oliveira

    2016-01-01

    Este artigo visa identificar os principais desafíos e tendências de qualificação e formação do turismólogo, bem como sua inserção profissional no contexto de um destino turístico (DT) majoritariamente formado por Micro e Pequenas Empresas (MPE’S). Com base na literatura especializada sobre MPE e sobre qualificação profissional em turismo, realizou-se uma pesquisa quali-quantitativa de cunho exploratório aplicado aos responsáveis pela contratação das organizações ligadas às Atividades Caracter...

  16. Approaches in setting up a system for certification of the Medical Physicists in some European Countries - possibilities for application in Bulgaria

    International Nuclear Information System (INIS)

    Dimov, A.; Slavchev, A.; Tabakov, S.; Stoeva, M.; Lichev, A.

    2004-01-01

    In Europe there are different approaches for harmonization with the Medical Exposure Directive (MED) and the EFOMP recommendations concerning the medical physicists' certification. The two most appropriate types are: 1) Based on folder with evidences and 2) Based on continuous professional development (CPD) evidences assessed by credit points system. An example for certification type 1 is the Radiation Protection Advisers (RPA) certification made by RPA2000 in the UK, which is described in the report. The experience of the Netherlands, Germany, Switzerland, Austria and Belgium are also presented. The situation in Bulgaria is analysed and proposal for further improvement and harmonization with the EC and EFOMP are given. A conclusion is made efforts should be done for establishing of modern accreditation and registration scheme of the MP and MPE in Bulgaria. In Bulgaria there is an urgent need for education, training and official certification of new specialists in this field

  17. "De vil os stadig til livs"

    DEFF Research Database (Denmark)

    Nielsen, Asta Smedegaard

    Med udgangspunkt i et perspektiv på terrortruslen mod Danmark som et diskursivt og oplevet fænomen udforskes de betydningskonstruktioner, der skabes i public service-medierne DR1 og TV2’s tv-nyhedsformidling om truslen, med særligt fokus på konstruktioner af racial, national og etnisk enshed og f...... bestræbelserne til at forstå og bekæmpe terrortruslen. Afhandlingen lægger vægt på betydningen af ’race’ i disse betydningskonstruktioner, idet analyserne peger på, at Breiviks hvidhed havde væsentlig betydning for den individualisering, der skete af ham og hans terror....

  18. Topology optimum design of compliant mechanisms using modified ant colony optimization

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Kwang Seon; Han, Seog Young [Hanyang University, Seoul (Korea, Republic of)

    2015-08-15

    A Modified ant colony optimization (MACO) algorithm was suggested for topology optimal design of compliant mechanisms since standard ACO cannot provide an appropriate optimal topology. In order to improve computational efficiency and suitability of standard ACO algorithm in topology optimization for compliant mechanisms, a continuous variable, called the 'Element contribution significance (ECS),'is employed, which serves to replace the positions of ants in the standard ACO algorithm, and assess the importance of each element in the optimization process. MACO algorithm was applied to topology optimizations of both linear and geometrically nonlinear compliant mechanisms using three kinds of objective functions, and optimized topologies were compared each other. From the comparisons, it was concluded that MACO algorithm can effectively be applied to topology optimizations of linear and geometrically nonlinear compliant mechanisms, and the ratio of Mutual potential energy (MPE) to Strain energy (SE) type of objective function is the best for topology optimal design of compliant mechanisms.

  19. Aerodynamic findings and Voice Handicap Index in Parkinson's disease.

    Science.gov (United States)

    Motta, Sergio; Cesari, Ugo; Paternoster, Mariano; Motta, Giovanni; Orefice, Giuseppe

    2018-04-23

    To verify possible relations between vocal disability and aerodynamic measures in selected Parkinson's disease (PD) patients with low/moderate-grade dysphonia. Fifteen idiopathic dysphonic PD male patients were examined and compared with 15 euphonic subjects. Testing included the following measures: Voice Handicap Index (VHI), maximum phonation time (MPT), mean estimated subglottal pressure (MESGP), mean sound pressure level (MSPL), mean phonatory power (MPP), mean phonatory efficiency (MPE) and mean phonatory resistance (MPR). Statistical analysis showed: a significant reduction in MPR and MSPL in PD subjects compared to the healthy ones; a significant positive correlation between VHI score and MSPL, MPR, MPP, MESGP and a significant negative correlation between VHI and MTP within PD subjects. Test for multiple linear regression showed a significant correlation between VHI score, MPT, MPR and MSPL. A relationship between VHI and aerodynamic measures was shown in the present study. Compensatory mechanisms may aggravate vocal disability in PD subjects.

  20. Mathematical paradigms of climate science

    CERN Document Server

    Cannarsa, Piermarco; Jones, Christopher; Portaluri, Alessandro

    2016-01-01

    This book, featuring a truly interdisciplinary approach, provides an overview of cutting-edge mathematical theories and techniques that promise to play a central role in climate science. It brings together some of the most interesting overview lectures given by the invited speakers at an important workshop held in Rome in 2013 as a part of MPE2013 (“Mathematics of Planet Earth 2013”). The aim of the workshop was to foster the interaction between climate scientists and mathematicians active in various fields linked to climate sciences, such as dynamical systems, partial differential equations, control theory, stochastic systems, and numerical analysis. Mathematics and statistics already play a central role in this area. Likewise, computer science must have a say in the efforts to simulate the Earth’s environment on the unprecedented scale of petabytes. In the context of such complexity, new mathematical tools are needed to organize and simplify the approach. The growing importance of data assimilation te...

  1. Neural networks applied to characterize blends containing refined and extra virgin olive oils.

    Science.gov (United States)

    Aroca-Santos, Regina; Cancilla, John C; Pariente, Enrique S; Torrecilla, José S

    2016-12-01

    The identification and quantification of binary blends of refined olive oil with four different extra virgin olive oil (EVOO) varietals (Picual, Cornicabra, Hojiblanca and Arbequina) was carried out with a simple method based on combining visible spectroscopy and non-linear artificial neural networks (ANNs). The data obtained from the spectroscopic analysis was treated and prepared to be used as independent variables for a multilayer perceptron (MLP) model. The model was able to perfectly classify the EVOO varietal (100% identification rate), whereas the error for the quantification of EVOO in the mixtures containing between 0% and 20% of refined olive oil, in terms of the mean prediction error (MPE), was 2.14%. These results turn visible spectroscopy and MLP models into a trustworthy, user-friendly, low-cost technique which can be implemented on-line to characterize olive oil mixtures containing refined olive oil and EVOOs. Copyright © 2016 Elsevier B.V. All rights reserved.

  2. Evaluation of Applicability of Global Solar Radiation Prediction Models for Kocaeli

    Directory of Open Access Journals (Sweden)

    Nurullah ARSLANOĞLU

    2016-04-01

    Full Text Available Design and analyses of solar energy systems needs value of global solar radiation falling on the surface of the earth. In this study,  thirty relative sunshine duration based regression models in the literature for determining the monthly average daily global solar radiation on a horizontal surface for Kocaeli were investigated. To indicate the performance of the models, the following statistical test methods are used: mean absolute bias error (MABE, mean bias error (MBE, mean absolute percent error (MAPE, mean percent error (MPE, root mean square error (RMSE. According to the statistical performance, Lewis model (Model 23, Model-18 (Jin et al. and Model 8 (Bahel et al. showed the best estimation of the global solar radiation on a horizontal surface for Kocaeli.

  3. Remembering and Telling: Narrative Coherence and Phenomenal Aspects of Autobiographical Memories

    Directory of Open Access Journals (Sweden)

    Gustavo Gauer

    2010-01-01

    Full Text Available Investigated the relationship between phenomenal qualities of autobiographical memories and narrative structure of written reports of them. In Experiment 1, 30 undergraduates provided 2 reports, the most momentous event of their lives (MPE and their earliest childhood recollection (ECR. Reports were coded for 2 variables: narrative coherence (NC, and event specificity (SP. No significant relationship was found between NC and SP, nor between SP and type of event. Experiment 2 asked 40 undergraduates to report MPEs and correlated NC and subjective ratings of events from the Autobiographical Memory Questionnaire (AMQ: vividness of imagery, recollection, importance, consequences, and rehearsal. A significant correlation between importance rating and the orientation index points out to the flashbulb aspect of the memories. Significant correlation between volume report and recollection indicates an interaction between higher indices of recollection and individual's predisposition to report the event in written form. Results did not corroborate a hypothesis of identity between autobiographical memory representation and expression.

  4. Experimental approach for the uncertainty assessment of 3D complex geometry dimensional measurements using computed tomography at the mm and sub-mm scales

    DEFF Research Database (Denmark)

    Jiménez, Roberto; Torralba, Marta; Yagüe-Fabra, José A.

    2017-01-01

    The dimensional verification of miniaturized components with 3D complex geometries is particularly challenging. Computed Tomography (CT) can represent a suitable alternative solution to micro metrology tools based on optical and tactile techniques. However, the establishment of CT systems......’ traceability when measuring 3D complex geometries is still an open issue. In this work, an alternative method for the measurement uncertainty assessment of 3D complex geometries by using CT is presented. The method is based on the micro-CT system Maximum Permissible Error (MPE) estimation, determined...... experimentally by using several calibrated reference artefacts. The main advantage of the presented method is that a previous calibration of the component by a more accurate Coordinate Measuring System (CMS) is not needed. In fact, such CMS would still hold all the typical limitations of optical and tactile...

  5. Chinese handwriting recognition an algorithmic perspective

    CERN Document Server

    Su, Tonghua

    2013-01-01

    This book provides an algorithmic perspective on the recent development of Chinese handwriting recognition. Two technically sound strategies, the segmentation-free and integrated segmentation-recognition strategy, are investigated and algorithms that have worked well in practice are primarily focused on. Baseline systems are initially presented for these strategies and are subsequently expanded on and incrementally improved. The sophisticated algorithms covered include: 1) string sample expansion algorithms which synthesize string samples from isolated characters or distort realistic string samples; 2) enhanced feature representation algorithms, e.g. enhanced four-plane features and Delta features; 3) novel learning algorithms, such as Perceptron learning with dynamic margin, MPE training and distributed training; and lastly 4) ensemble algorithms, that is, combining the two strategies using both parallel structure and serial structure. All the while, the book moves from basic to advanced algorithms, helping ...

  6. A Hierarchical Approach Using Machine Learning Methods in Solar Photovoltaic Energy Production Forecasting

    Directory of Open Access Journals (Sweden)

    Zhaoxuan Li

    2016-01-01

    Full Text Available We evaluate and compare two common methods, artificial neural networks (ANN and support vector regression (SVR, for predicting energy productions from a solar photovoltaic (PV system in Florida 15 min, 1 h and 24 h ahead of time. A hierarchical approach is proposed based on the machine learning algorithms tested. The production data used in this work corresponds to 15 min averaged power measurements collected from 2014. The accuracy of the model is determined using computing error statistics such as mean bias error (MBE, mean absolute error (MAE, root mean square error (RMSE, relative MBE (rMBE, mean percentage error (MPE and relative RMSE (rRMSE. This work provides findings on how forecasts from individual inverters will improve the total solar power generation forecast of the PV system.

  7. Intranasal Pharmacokinetic Data for Triptans Such as Sumatriptan and Zolmitriptan Can Render Area Under the Curve (AUC) Predictions for the Oral Route: Strategy Development and Application

    DEFF Research Database (Denmark)

    Srinivas, Nuggehally R.; Syed, Muzeeb

    2016-01-01

    Limited pharmacokinetic sampling strategy may be useful for predicting the area under the curve (AUC) for triptans and may have clinical utility as a prospective tool for prediction. Using appropriate intranasal pharmacokinetic data, a Cmax vs. AUC relationship was established by linear regression...... models for sumatriptan and zolmitriptan. The predictions of the AUC values were performed using published mean/median Cmax data and appropriate regression lines. The quotient of observed and predicted values rendered fold-difference calculation. The mean absolute error (MAE), mean positive error (MPE......), mean negative error (MNE), root mean square error (RMSE), correlation coefficient (r), and the goodness of the AUC fold prediction were used to evaluate the two triptans. Also, data from the mean concentration profiles at time points of 1 hour (sumatriptan) and 3 hours (zolmitriptan) were used...

  8. Avaliação de Micro e Pequenas Empresas Utilizando a Metodologia Multicritério e o Método do Fluxo de Caixa Descontado

    Directory of Open Access Journals (Sweden)

    Marcus Vinicius Andrade de Lima

    2010-01-01

    Full Text Available Neste artigo é apresentada uma contribuição ao método do fluxo de caixa descontado utilizando a metodologia multicritério de apoio à decisão. Essa metodologia incorpora variáveis de natureza qualitativa e subjetiva ao método tradicional do fluxo de caixa descontado utilizado na avaliação de empresas. Para ilustrar o método proposto foi realizado um estudo descritivo de natureza exploratória aplicado a um multicaso. A intervenção foi em Micro e Pequenas Empresas (MPE do ramo químico, farmacêutico e de turismo. Como resultado, o avaliador ajustou o preço do negócio levando em conta a resultante da mixagem entre as duas metodologias.

  9. Artificial neural network and response surface methodology modeling in mass transfer parameters predictions during osmotic dehydration of Carica papaya L.

    Directory of Open Access Journals (Sweden)

    J. Prakash Maran

    2013-09-01

    Full Text Available In this study, a comparative approach was made between artificial neural network (ANN and response surface methodology (RSM to predict the mass transfer parameters of osmotic dehydration of papaya. The effects of process variables such as temperature, osmotic solution concentration and agitation speed on water loss, weight reduction, and solid gain during osmotic dehydration were investigated using a three-level three-factor Box-Behnken experimental design. Same design was utilized to train a feed-forward multilayered perceptron (MLP ANN with back-propagation algorithm. The predictive capabilities of the two methodologies were compared in terms of root mean square error (RMSE, mean absolute error (MAE, standard error of prediction (SEP, model predictive error (MPE, chi square statistic (χ2, and coefficient of determination (R2 based on the validation data set. The results showed that properly trained ANN model is found to be more accurate in prediction as compared to RSM model.

  10. CHIS – Letter from French health insurance authorities "Assurance Maladie" and “frontalier” status

    CERN Multimedia

    2014-01-01

    Certain members of the personnel residing in France have recently received a letter, addressed to themselves and/or their spouse, from the French health insurance authorities (Assurance Maladie) on the subject of changes in the health insurance coverage of “frontalier” workers.   It should be recalled that employed members of personnel (MPE) are not affected by the changes made by the French authorities to frontalier  workers' "right to choose" (droit d'option) in matters of health insurance (see the CHIS website for more details), which took effect as of 1 June 2014, as they are not considered to be frontalier workers. Associated members of the personnel (MPA) are not affected either, unless they live in France and are employed by a Swiss institute. For the small number of MPAs in the latter category who might be affected, as well as for family members who do have frontalier status, CERN is still in discussion with the authorities o...

  11. Diagnosis and treatment of trigeminal schwannomas extending into both the middle and posterior cranial fossa

    Institute of Scientific and Technical Information of China (English)

    徐启武; 车晓明; 胡杰; 杨伯捷

    2004-01-01

    @@ Trigeminal schwannomas (TSs) account for 0.1%-0.4% of all intracranial tumors and 1%-8% of intracranial schwannomas.1,2 Yoshida and Kawase3 classified TSs into 6 types according to their locations: M (TS involving the middle cranial fossa), P (TS involving the posterior cranial fossa), E (TS located at extracranial space), MP (TS involving both the middle and the posterior cranial fossa), ME (TS involving the middle cranial fossa and the extracranial space), and MPE (TS involving the the middle and the posterior cranial fossa and the extracranial space). Of these types, MP is the commonest, but is difficult to be totally removed. Between January 1984 and June 2003, we surgically treated 28 patients with TSs of type MP and obtained satisfactory results. To make a correct diagnosis of TS, to select appropriate surgical approach, and to improve surgical outcome of TS of type MP, we analysed the related clinical data and experiences.

  12. Diagnostic value of soluble B7-H4 and carcinoembryonic antigen in distinguishing malignant from benign pleural effusion.

    Science.gov (United States)

    Jing, Xiaogang; Wei, Fei; Li, Jing; Dai, Lingling; Wang, Xi; Jia, Liuqun; Wang, Huan; An, Lin; Yang, Yuanjian; Zhang, Guojun; Cheng, Zhe

    2018-03-01

    To explore the diagnostic value of joint detection of soluble B7-H4 (sB7-H4) and carcinoembryonic antigen (CEA) in identifying malignant pleural effusion (MPE) from benign pleural effusion (BPE). A total of 97 patients with pleural effusion specimens were enrolled from The First Affiliated Hospital of Zhengzhou University between June 2014 and December 2015. All cases were categorized into malignant pleural effusion group (n = 55) and benign pleural effusion group (n = 42) according to etiologies. Enzyme-linked immunosorbent assay was applied to examine the levels of sB7-H4 in pleural effusion and meanwhile CEA concentrations were detected by electro-chemiluminescence immunoassays. Receiver operating characteristic (ROC) curve was established to assess the diagnostic value of sB7-H4 and CEA in pleural effusion. The correlation between sB7-H4 and CEA levels was analyzed by Pearson's product-moment. The concentrations of sB7-H4 and CEA in MPE exhibited obviously higher than those of BPE ([60.08 ± 35.04] vs. [27.26 ± 9.55] ng/ml, P = .000; [41.49 ± 37.16] vs. [2.41 ± 0.94] ng/ml, P = .000). The AUC area under ROC curve of sB7-H4 and CEA was 0.884 and 0.954, respectively. Two cutoff values by ROC curve analysis of sB7-H4 36.5 ng/ml and CEA 4.18 ng/ml were obtained, with a corresponding sensitivity (81.82%, 87.28%), specificity (90.48%, 95.24%), accuracy (85.57%, 90.72%), positive predictive value (PPV) (91.84%, 96.0%), negative predictive value (NPV) (79.17%, 85.11%), positive likelihood ratio (PLR) (8.614, 18.327), and negative likelihood ratio (NLR) (0.201, 0.134). When sB7-H4 and CEA were combined to detect pleural effusion, it obtained a higher sensitivity 90.91% and specificity 97.62%. Furthermore, correlation analysis result showed that the level of sB7-H4 was correlated with CEA level (r = .770, P = .000). sB7-H4 was a potentially valuable tumor marker in the differentiation between BPE and MPE. The combined detection of sB7-H4 and

  13. An evaluation of chemical photoreactivity and the relationship to phototoxicity.

    Science.gov (United States)

    Kleinman, Mark H; Smith, Mark D; Kurali, Edit; Kleinpeter, Sarah; Jiang, Kaina; Zhang, Yongxia; Kennedy-Gabb, Sonya A; Lynch, Anthony M; Geddes, Chris D

    2010-11-01

    The existing regulatory guidance for photosafety testing of new drug products states that studies are warranted for those chemicals that both absorb light in the range of 290-700 nm, and that are either applied locally/topically, or "reach" (EMEA)/"significantly partition" (FDA) to the skin or eyes. The initial in vitro study recommended for the assessment of phototoxic potential is the 3T3 Neutral Red Uptake (NRU) Assay. The current study was undertaken to establish superior triggers for the initiation of biological photosafety testing. In this study, photophysical and photochemical parameters for 40 drug or drug-like molecules were studied. Principal Component Analysis (PCA), Partial Least Squares-Discriminant Analysis (PLS-DA), and a fivefold cross-validation PLS algorithm were used to evaluate the relationship between subsets of photophysical and photochemical parameters with the 3T3 NRU PIF/MPE (Photo Irritation Factor/Mean Photo Effect) results. The parameters most indicative of a 3T3 NRU positive PIF or MPE score were the extent of degradation in solution, the quantum yield of formation of singlet oxygen and the relative formation of superoxide anion. The results demonstrate that while absorption of light is critical to the induction of a light-induced process, it is the resultant events that may be used to predict the 3T3 NRU assay result. It is therefore proposed that the trigger for photosafety testing be revised to include a molecular basis for photoreactivity. From this limited investigation, estimated thresholds leading to 3T3 NRU positive results due to photodegradation, formation of singlet oxygen quantum yield or a relative superoxide anion formation value are proposed. Copyright © 2010 Elsevier Inc. All rights reserved.

  14. Identification of tertiary butyl alcohol (TBA)-utilizing organisms in BioGAC reactors using 13C-DNA stable isotope probing.

    Science.gov (United States)

    Aslett, Denise; Haas, Joseph; Hyman, Michael

    2011-09-01

    Biodegradation of the gasoline oxygenates methyl tertiary-butyl ether (MTBE) and ethyl tertiary-butyl ether (ETBE) can cause tertiary butyl alcohol (TBA) to accumulate in gasoline-impacted environments. One remediation option for TBA-contaminated groundwater involves oxygenated granulated activated carbon (GAC) reactors that have been self-inoculated by indigenous TBA-degrading microorganisms in ground water extracted from contaminated aquifers. Identification of these organisms is important for understanding the range of TBA-metabolizing organisms in nature and for determining whether self-inoculation of similar reactors is likely to occur at other sites. In this study (13)C-DNA-stable isotope probing (SIP) was used to identify TBA-utilizing organisms in samples of self-inoculated BioGAC reactors operated at sites in New York and California. Based on 16S rRNA nucleotide sequences, all TBA-utilizing organisms identified were members of the Burkholderiales order of the β-proteobacteria. Organisms similar to Cupriavidus and Methylibium were observed in both reactor samples while organisms similar to Polaromonas and Rhodoferax were unique to the reactor sample from New York. Organisms similar to Hydrogenophaga and Paucibacter strains were only detected in the reactor sample from California. We also analyzed our samples for the presence of several genes previously implicated in TBA oxidation by pure cultures of bacteria. Genes Mpe_B0532, B0541, B0555, and B0561 were all detected in (13)C-metagenomic DNA from both reactors and deduced amino acid sequences suggested these genes all encode highly conserved enzymes. One gene (Mpe_B0555) encodes a putative phthalate dioxygenase-like enzyme that may be particularly appropriate for determining the potential for TBA oxidation in contaminated environmental samples.

  15. Development and blood compatibility assessment of electrospun polyvinyl alcohol blended with metallocene polyethylene and plectranthus amboinicus (PVA/mPE/PA) for bone tissue engineering.

    Science.gov (United States)

    Qi, Jie; Zhang, Huang; Wang, Yingzhou; Mani, Mohan Prasath; Jaganathan, Saravana Kumar

    2018-01-01

    Currently, the design of extracellular matrix (ECM) with nanoscale properties in bone tissue engineering is challenging. For bone tissue engineering, the ECM must have certain properties such as being nontoxic, highly porous, and should not cause foreign body reactions. In this study, the hybrid scaffold based on polyvinyl alcohol (PVA) blended with metallocene polyethylene (mPE) and plectranthus amboinicus (PA) was fabricated for bone tissue engineering via electrospinning. The fabricated hybrid nanocomposites were characterized by scanning electron microscopy (SEM), Fourier transform and infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), contact angle measurement, and atomic force microscopy (AFM). Furthermore, activated partial thromboplastin time (APTT), prothrombin time (PT), and hemolytic assays were used to investigate the blood compatibility of the prepared hybrid nanocomposites. The prepared hybrid nanocomposites showed reduced fiber diameter (238±45 nm) and also increased porosity (87%) with decreased pore diameter (340±86 nm) compared with pure PVA. The interactions between PVA, mPE, and PA were identified by the formation of the additional peaks as revealed in FTIR. Furthermore, the prepared hybrid nanocomposites showed a decreased contact angle of 51°±1.32° indicating a hydrophilic nature and exhibited lower thermal stability compared to pristine PVA. Moreover, the mechanical results revealed that the electrospun scaffold showed an improved tensile strength of 3.55±0.29 MPa compared with the pristine PVA (1.8±0.52 MPa). The prepared hybrid nanocomposites showed delayed blood clotting as noted in APTT and PT assays indicating better blood compatibility. Moreover, the hemolysis assay revealed that the hybrid nanocomposites exhibited a low hemolytic index of 0.6% compared with pure PVA, which was 1.6% suggesting the safety of the developed nanocomposite to red blood cells (RBCs). The prepared nanocomposites exhibited better physico

  16. Action spectrum for photochemical retinal pigment epithelium (RPE) disruption in an in vivo monkey model

    Science.gov (United States)

    Zhang, Jie; Sabarinathan, Ranjani; Bubel, Tracy; Williams, David R.; Hunter, Jennifer J.

    2016-03-01

    Observations of RPE disruption and autofluorescence (AF) photobleaching at light levels below the ANSI photochemical maximum permissible exposure (MPE) (Morgan et al., 2008) indicates a demand to modify future light safety standards to protect the retina from harm. To establish safe light exposures, we measured the visible light action spectrum for RPE disruption in an in vivo monkey model with fluorescence adaptive optics retinal imaging. Using this high resolution imaging modality can provide insight into the consequences of light on a cellular level and allow for longitudinal monitoring of retinal changes. The threshold retinal radiant exposures (RRE) for RPE disruption were determined for 4 wavelengths (460, 488, 544, and 594 nm). The anaesthetized macaque retina was exposed to a uniform 0.5° × 0.5° field of view (FOV). Imaging within a 2° × 2° FOV was performed before, immediately after and at 2 week intervals for 10 weeks. At each wavelength, multiple RREs were tested with 4 repetitions each to determine the threshold for RPE disruption. For qualitative analysis, RPE disruption is defined as any detectable change from the pre exposure condition in the cell mosaic in the exposed region relative to the corresponding mosaic in the immediately surrounding area. We have tested several metrics to evaluate the RPE images obtained before and after exposure. The measured action spectrum for photochemical RPE disruption has a shallower slope than the current ANSI photochemical MPE for the same conditions and suggests that longer wavelength light is more hazardous than other measurements would suggest.

  17. [Occupational exposure of welders to ultraviolet and "blue light" radiation emitted during TIG and MMA welding based on field measurements].

    Science.gov (United States)

    Wolska, Agnieszka

    2013-01-01

    The aim of the study was to present the results of welders' occupational exposure to "blue light" and UV radiation carried out at industrial workstations during TIG and MMA welding. Measurements were performed at 13 workstations (TIG welding: 6; MMA welding: 7), at which different welding parameters and materials were used. The radiation level was measured using a wide-range radiometer and a set of detectors, whose spectral responses were adequately fit to particular hazard under study. The measurement points corresponded with the location of eye and hand. The highest values of eye irradiance were found for aluminum TIG welding. Effective irradiance of actinic UV was within the range E(s) = 7.79-37.6 W/m2; UVA total irradiance, E(UVA) = 18-53.1 W/m2 and effective blue-light irradiance E(B) = 35-67 W/m2. The maximum allowance time ranged from 1.7 to 75 s, which means that in some cases even unintentional very short eye exposure can exceed MPE. The influence of welded material and the type of electrode coating on the measured radiation level were evidenced. The exceeded value of MPE for photochemical hazard arising for the eyes and skin was found at all measured workstations. Welders should use appropriately the eye and face protective equipment and avoid direct staring at welding arc when starting an arc-welding operation. Besides, the lack of head and neck skin protection can induce acute and chronic harmful health effects. Therefore, an appropriate wear of personal protective equipment is essential for welders' health.

  18. Carbohydrate co-ingestion with protein does not further augment post-prandial muscle protein accretion in older men

    Directory of Open Access Journals (Sweden)

    Hamer Henrike M

    2013-01-01

    Full Text Available Abstract Background A blunted muscle protein synthetic response to protein ingestion may contribute to the age related loss of muscle tissue. We hypothesized that the greater endogenous insulin release following co-ingestion of carbohydrate facilitates post-prandial muscle protein accretion after ingesting a meal-like bolus of protein in older males. Methods Twenty-four healthy older men (75±1 y were randomly assigned to ingest 20 g intrinsically L-[1-13C] phenylalanine-labeled casein protein with (PRO-CHO or without (PRO 40 g carbohydrate. Ingestion of specifically produced intrinsically L-[1-13C] phenylalanine labeled protein allowed us to assess post-prandial incorporation of dietary protein derived amino acids into muscle protein. Blood samples were collected at regular intervals, with muscle biopsies being obtained prior to and 2 and 6 h after protein ingestion. Results Plasma glucose and insulin concentrations showed a greater increase in PRO-CHO compared with PRO (P13C] phenylalanine enrichments tended to increase to a greater extent in PRO-CHO compared with PRO during the first 2 h after protein ingestion (0.0072±0.0013 vs 0.0046±0.010 MPE, respectively; P=0.13. However, 6 h after protein ingestion, differences in muscle protein-bound L-[1-13C] phenylalanine enrichments were no longer observed between experiments (0.0213±0.0024 vs 0.0185±0.0010 MPE, respectively; P=0.30. Conclusions This study shows that carbohydrate ingestion may accelerate, but does not further augment post-prandial incorporation of dietary protein derived amino acids into muscle protein in healthy elderly men.

  19. An effective placental cotyledons proteins extraction method for 2D gel electrophoresis.

    Science.gov (United States)

    Tan, Niu J; Daim, Leona D J; Jamil, Amilia A M; Mohtarrudin, Norhafizah; Thilakavathy, Karuppiah

    2017-03-01

    Effective protein extraction is essential especially in producing a well-resolved proteome on 2D gels. A well-resolved placental cotyledon proteome, with good reproducibility, have allowed researchers to study the proteins underlying the physiology and pathophysiology of pregnancy. The aim of this study is to determine the best protein extraction protocol for the extraction of protein from placental cotyledons tissues for a two-dimensional gel electrophoresis (2D-GE). Based on widely used protein extraction strategies, 12 different extraction methodologies were carefully selected, which included one chemical extraction, two mechanical extraction coupled protein precipitations, and nine chemical extraction coupled protein precipitations. Extracted proteins were resolved in a one-dimensional gel electrophoresis and 2D-GE; then, it was compared with set criteria: extraction efficacy, protein resolution, reproducibility, and recovery efficiency. Our results revealed that a better profile was obtained by chemical extraction in comparison to mechanical extraction. We further compared chemical extraction coupled protein precipitation methodologies, where the DNase/lithium chloride-dense sucrose homogenization coupled dichloromethane-methanol precipitation (DNase/LiCl-DSH-D/MPE) method showed good protein extraction efficiency. This, however, was carried out with the best protein resolution and proteome reproducibility on 2D-gels. DNase/LiCl-DSH-D/MPE was efficient in the extraction of proteins from placental cotyledons tissues. In addition, this methodology could hypothetically allow the protein extraction of any tissue that contains highly abundant lipid and glycogen. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  20. [Study on the pathogens correlated to sexually transmitted diseases in 285 pre-pubertal girls with vulvovaginitis in Beijing].

    Science.gov (United States)

    Liu, Xiao-Yan; Sun, Hong-Mei; Feng, Yan-Ling; Hu, Jin; Zhao, Han-Qing; Zhang, Li-Ya

    2007-08-01

    To study the relationship between vulvovaginitis in pre-pubertal girls and pathogens as Chlamydia trachomatis (Ct), N. gonorrhoeae (Ng), Mycoplasma, Ureaplasma urealyticum (Uu), Mycoplasma hominis (Mh), M. genitalium (Mg), M. fermentans (Mf) and M. penetrans (Mpe), as well as to find out the proportion of mycoplasma which is correlated to sexually transmitted diseases (STD) and AIDS. METHODS Vulvae swab specimens from 285 pre-pubertal girls with vulvovaginitis (case group) and 128 healthy girls (control group) were collected and detected by nested polymerase chain reaction (nPCR) to identify the existence of pathogens as Ct, Ng, Uu, Mh, Mg, Mf and Mpe. nPCR with both high specificity and sensitivity, would not be influenced by the amount of pathogens in specimens or inactivated during the process of storage or transportation. The rate of detection on pathogens was 59.65% in the 285 specimens from case group including 'one kind of pathogen in one specimen' as 37.54% and 'two kinds' as 16.84% and 'three kinds' as 5.26%. However, in the 128 specimens from control group, the detectable rate of pathogen was 6.25%. Relationships were found between Ng (P vulvovaginitis in pre-pubertal girls. In control group the pathogens were detected from 7 specimens including 5 Uu and 2 Mh. Some of the pathogens were correlated to STD and were important in causing vulvovaginitis in pre-pubertal girls. Vulvovaginitis might have been caused by more than one kind of pathogen in pre-pubertal girls. The locations of Mg, Mf and Ng in outer genital tracts were correlated to seasonal change. Macrolide seemed to be quite effective clinically in treating urogenital tract infection caused by mycoplasma and Ct.

  1. Home composting as an alternative treatment option for organic household waste in Denmark: An environmental assessment using life cycle assessment-modelling

    International Nuclear Information System (INIS)

    Andersen, J.K.; Boldrin, A.; Christensen, T.H.; Scheutz, C.

    2012-01-01

    An environmental assessment of the management of organic household waste (OHW) was performed from a life cycle perspective by means of the waste-life cycle assessment (LCA) model EASEWASTE. The focus was on home composting of OHW in Denmark and six different home composting units (with different input and different mixing frequencies) were modelled. In addition, incineration and landfilling was modelled as alternatives to home composting. The most important processes contributing to the environmental impact of home composting were identified as greenhouse gas (GHG) emissions (load) and the avoided emissions in relation to the substitution of fertiliser and peat when compost was used in hobby gardening (saving). The replacement of fertiliser and peat was also identified as one of the most sensible parameters, which could potentially have a significant environmental benefit. Many of the impact categories (especially human toxicity via water (HTw) and soil (HTs)) were affected by the heavy metal contents of the incoming OHW. The concentrations of heavy metals in the compost were below the threshold values for compost used on land and were thus not considered to constitute a problem. The GHG emissions were, on the other hand, dependent on the management of the composting units. The frequently mixed composting units had the highest GHG emissions. The environmental profiles of the home composting scenarios were in the order of −2 to 16 milli person equivalents (mPE) Mg −1 wet waste (ww) for the non-toxic categories and −0.9 to 28 mPE Mg −1 ww for the toxic categories. Home composting performed better than or as good as incineration and landfilling in several of the potential impact categories. One exception was the global warming (GW) category, in which incineration performed better due to the substitution of heat and electricity based on fossil fuels.

  2. Occupational exposure of welders to ultraviolet and "blue light" radiation emitted during TIG and MMA welding based on field measuremants

    Directory of Open Access Journals (Sweden)

    Agnieszka Wolska

    2013-02-01

    Full Text Available Background: The aim of the study was to present the results of welders' occupational exposure to "blue light" and UV radiation carried out at industrial workstations during TIG and MMA welding. Materials and methods: Measurements were performed at 13 workstations (TIG welding: 6; MMA welding: 7, at which different welding parameters and materials were used. The radiation level was measured using a wide-range radiometer and a set of detectors, whose spectral responses were adequately fit to particular hazard under study. The measurement points corresponded with the location of eye and hand. Results: The highest values of eye irradiance were found for aluminum TIG welding. Effective irradiance of actinic UV was within the range Es = 7.79-37.6 W/m2; UVA total irradiance, EUVA = 18-53.1 W/m2 and effective blue-light irradiance EB = 35-67 W/m2. The maximum allowance time ranged from 1.7 to 75 s, which means that in some cases even unintentional very short eye exposure can exceed MPE. Conclusions: The influence of welded material and the type of electrode coating on the measured radiation level were evidenced. The exceeded value of MPE for photochemical hazard arising for the eyes and skin was found at all measured workstations. Welders should use appropriately the eye and face protective equipment and avoid direct staring at welding arc when starting an arcwelding operation. Besides, the lack of head and neck skin protection can induce acute and chronic harmful health effects. Therefore, an appropriate wear of personal protective equipment is essential for welders' health. Med Pr 2013;64(1:69–82

  3. Analgesic effect of the aqueous and ethanolic extracts of clove

    Directory of Open Access Journals (Sweden)

    Mina Kamkar Asl

    2013-04-01

    Full Text Available Objective: The beneficial effects of clove on toothache have been well documented. We have also previously shown the analgesic effects of clove essential oil. The present work was done to investigate the analgesic effects of the aqueous extract of clove using hot plate test. The possible role of opioid receptors in the analgesic effects of clove was also investigated using naloxone. Materials and Methods: Ninety male mice were divided into nine groups: (1 Saline, (2-4 Aaqueous (Aq 50, Aq 100, and Aq 200 groups which were treated with 50, 100, and 200 mg/kg of aqueous extract of clove, respectively, (5-7 Ethanolic (Eth 50, Eth 100, and Eth 200 groups which were treated with 50, 100, and 200 mg/kg of ethanolic extract of clove, respectively, and (8-9 Aq 100- Naloxone and Aq 200- Naloxone which were pretreated with 4 mg/kg of naloxone before injection of 100 or 200 mg/kg of the aqueous extract. The hot plate test was performed as a base record 10 min before injection of drugs and consequently repeated every 10 minutes after the injection. Results: The maximal percent effect (MPE in the animal groups treated with 50, 100, and 200 mg/kg of aqueous extract was significantly higher than the control group. Pretreatment with naloxone reduced the analgesic effects of both 100 and 200 mg/kg of the aqueous extract. Administration of all three doses of the ethanloic extract also non-significantly increased the MPE. Conclusion: The results of the present study showed that aqueous extract of clove has analgesic effect in mice demonstrated by hot plate test which is reversible by naloxone. The role of opioid system in the analgesic effect of clove might be suggested. However, more investigations are needed to elucidate the exact mechanism(s.

  4. Incorporating Satellite Precipitation Estimates into a Radar-Gauge Multi-Sensor Precipitation Estimation Algorithm

    Directory of Open Access Journals (Sweden)

    Yuxiang He

    2018-01-01

    Full Text Available This paper presents a new and enhanced fusion module for the Multi-Sensor Precipitation Estimator (MPE that would objectively blend real-time satellite quantitative precipitation estimates (SQPE with radar and gauge estimates. This module consists of a preprocessor that mitigates systematic bias in SQPE, and a two-way blending routine that statistically fuses adjusted SQPE with radar estimates. The preprocessor not only corrects systematic bias in SQPE, but also improves the spatial distribution of precipitation based on SQPE and makes it closely resemble that of radar-based observations. It uses a more sophisticated radar-satellite merging technique to blend preprocessed datasets, and provides a better overall QPE product. The performance of the new satellite-radar-gauge blending module is assessed using independent rain gauge data over a five-year period between 2003–2007, and the assessment evaluates the accuracy of newly developed satellite-radar-gauge (SRG blended products versus that of radar-gauge products (which represents MPE algorithm currently used in the NWS (National Weather Service operations over two regions: (I Inside radar effective coverage and (II immediately outside radar coverage. The outcomes of the evaluation indicate (a ingest of SQPE over areas within effective radar coverage improve the quality of QPE by mitigating the errors in radar estimates in region I; and (b blending of radar, gauge, and satellite estimates over region II leads to reduction of errors relative to bias-corrected SQPE. In addition, the new module alleviates the discontinuities along the boundaries of radar effective coverage otherwise seen when SQPE is used directly to fill the areas outside of effective radar coverage.

  5. The CD44(high tumorigenic subsets in lung cancer biospecimens are enriched for low miR-34a expression.

    Directory of Open Access Journals (Sweden)

    Saroj K Basak

    Full Text Available Cellular heterogeneity is an integral part of cancer development and progression. Progression can be associated with emergence of cells that exhibit high phenotypic plasticity (including "de-differentiation" to primitive developmental states, and aggressive behavioral properties (including high tumorigenic potentials. We observed that many biomarkers that are used to identify Cancer Stem Cells (CSC can label cell subsets in an advanced clinical stage of lung cancer (malignant pleural effusions, or MPE. Thus, CSC-biomarkers may be useful for live sorting functionally distinct cell subsets from individual tumors, which may enable investigators to hone in on the molecular basis for functional heterogeneity. We demonstrate that the CD44(hi (CD44-high cancer cell subsets display higher clonal, colony forming potential than CD44(lo cells (n=3 and are also tumorigenic (n=2/2 when transplanted in mouse xenograft model. The CD44(hi subsets express different levels of embryonal (de-differentiation markers or chromatin regulators. In archived lung cancer tissues, ALDH markers co-localize more with CD44 in squamous cell carcinoma (n=5/7 than Adeno Carcinoma (n=1/12. MPE cancer cells and a lung cancer cell line (NCI-H-2122 exhibit chromosomal abnormalities and 1p36 deletion (n=3/3. Since miR-34a maps to the 1p36 deletion site, low miR-34a expression levels were detected in these cells. The colony forming efficiency of CD44(hi cells, characteristic property of CSC, can be inhibited by mir-34a replacement in these samples. In addition the highly tumorigenic CD44(hi cells are enriched for cells in the G2 phase of cell cycle.

  6. Gestão de capital de giro: contribuição para as micro e pequenas empresas no Brasil

    Directory of Open Access Journals (Sweden)

    Deborah Moraes Zouain

    2011-06-01

    Full Text Available Este artigo trata da importância das questões de capital de giro na gestão das micro e pequenas empresas (MPE no Brasil. Apresenta-se uma revisão dos conceitos de capital de giro e da importância das MPE no Brasil, além de uma discussão sobre a relevância de uma gestão financeira de curto prazo eficiente para o sucesso de um empreendimento de pequeno porte. Com características bem definidas, as micro e pequenas empresas são responsáveis pela geração da maior parte dos empregos formais no Brasil; apesar disso, ainda não contam com uma estrutura formal de apoio de crédito. O trabalho aponta como fator relevante para o sucesso das micro e pequenas empresas ter um bom gerenciamento do capital de giro. O mau gerenciamento desse fator contribui para o alto índice de mortalidade dessas empresas. Para que o administrador de capital de giro tenha êxito, é importante que haja um forte entrelaçamento com a administração estratégica, para uma solução definitiva do problema, isto é, que consista numa recuperação de lucratividade da empresa e as consequentes recomposições de seu fluxo de caixa, fazendo com que as micro e pequenas empresas consigam chegar à fase de maturidade.

  7. Fortune favours the bold: a higher predator reduces the impact of a native but not an invasive intermediate predator.

    Science.gov (United States)

    Barrios-O'Neill, Daniel; Dick, Jaimie T A; Emmerson, Mark C; Ricciardi, Anthony; MacIsaac, Hugh J; Alexander, Mhairi E; Bovy, Helene C

    2014-05-01

    Emergent multiple predator effects (MPEs) might radically alter predictions of predatory impact that are based solely on the impact of individuals. In the context of biological invasions, determining if and how the individual-level impacts of invasive predators relates to their impacts in multiple-individual situations will inform understanding of how such impacts might propagate through recipient communities. Here, we use functional responses (the relationship between prey consumption rate and prey density) to compare the impacts of the invasive freshwater mysid crustacean Hemimysis anomala with a native counterpart Mysis salemaai when feeding on basal cladoceran prey (i) as individuals, (ii) in conspecific groups and (iii) in conspecific groups in the presence of a higher fish predator, Gasterosteus aculeatus. In the absence of the higher predator, the invader consumed significantly more basal prey than the native, and consumption was additive for both mysid species - that is, group consumption was predictable from individual-level consumption. Invaders and natives were themselves equally susceptible to predation when feeding with the higher fish predator, but an MPE occurred only between the natives and higher predator, where consumption of basal prey was significantly reduced. In contrast, consumption by the invaders and higher predator remained additive. The presence of a higher predator serves to exacerbate the existing difference in individual-level consumption between invasive and native mysids. We attribute the mechanism responsible for the MPE associated with the native to a trait-mediated indirect interaction, and further suggest that the relative indifference to predator threat on the part of the invader contributes to its success and impacts within invaded communities. © 2013 The Authors. Journal of Animal Ecology © 2013 British Ecological Society.

  8. Pleural effusion in 11:14 translocation q1 multiple myeloma in the setting of proteasome inhibitor presents therapeutic complexity.

    Science.gov (United States)

    Ghannam, Malik; Bryan, Maria; Kuross, Erik; Berry, Brent

    2018-01-01

    Primary malignant pleural effusion has been reported in about 134 cases of multiple myeloma (MM). Associated pleural effusions in cases of MM portend a poor prognosis and identifying them is highly relevant. Reported is the case of a man diagnosed with MM who developed primary myelomatous pleural effusion in the setting of multiple relapses and subsequent mortality within 2 months of the pleural effusion diagnosis. A 61-year-old African American man was diagnosed with MM in 2011. He received induction therapy of lenalidomide and dexamethasone and an autologous stem cell transplant in 2012. Over the next 5 years, the patient went through alternating periods of remission and relapse that were treated with two rounds of thoracic spine radiation therapy and chemotherapeutic agents. In September 2017, the patient presented with worsening dyspnea and was found to have pleural effusion. Fluid analysis showed plasma cell dyscrasia. Fluid drainage was performed, then the patient was discharged after 1 week which was followed by rapid re-accumulation of fluid and rehospitalization about 10 days after discharge. The patient passed away a few weeks after the second admission. Pleural effusion carries a differential diagnosis which may include malignancy but is commonly thought to be less specific to multiple myeloma but should still remain in the differential diagnosis. To our knowledge, this is the first case of myelomatous pleural effusion (MPE) that was reported after multiple relapses of MM. MPE is a very rare complication of MM, and its presence is a strong indicator of imminent mortality and need for comfort care in case of multiple relapses. End-stage pleural effusion in MM in the setting of proteasome inhibitor adds more therapeutic and diagnostic challenges.

  9. Der Briefwechsel zwischen Karl Kreil und Alexander von Humboldt, ein wichtiger Beitrag zur Geschichte des Erdmagnetismus

    Directory of Open Access Journals (Sweden)

    Karin Reich

    2016-11-01

    Full Text Available Abstract The correspondence between Alexander von Humboldt und Karl Kreil was voluminous, it concerned earth magnetism. But only one letter has survived. This letter was written by Kreil on September 3, 1836; one day later Kreil wrote a letter to Carl Friedrich Gauss with nearly the same contents, some sentences are even literally corresponding. Four letters from Kreil to Humboldt were published in the „Annalen der Physik und Chemie“. Some letters were mentioned in the biographical literature dealing with Kreil. These letters show, that the correspondence covered at least the period until 1851 and give information about the intensive relationship between the two scientists. A further interesting source is the library of Humboldt which unfortunately has not survived. The catalogue mentions nine works of Kreil some of them where annotated by Humboldt. This makes it plausible that the contacts even lasted until 1856. Zusammenfassung Die Korrespondenz zwischen Alexander von Humboldt und Karl Kreil war umfangreich und betraf den Erdmagnetismus. Aber heute ist nur noch ein einziger Brief im Original bekannt. Dieser Brief, den Kreil am 3. September 1836 Alexander von Humboldt zukommen ließ, stimmt inhaltlich und teilweise wortwörtlich mit dem Brief überein, den Kreil nur einen Tag später, am 4. September 1836, an Carl Friedrich Gauß schickte. Vier Briefe von Kreil an Humboldt wurden in den „Annalen der Physik und Chemie“ publiziert, eine nicht allzu große Anzahl weiterer Briefe an Humboldt wurde in der biographischen Literatur über Kreil und in Briefen Kreils an Koller und Gauß erwähnt. Aber nicht nur die lückenhafte und bruchstückhaft bekannte Korrespondenz zwischen Humboldt und Kreil, die bis 1851 reicht, gibt Aufschluss über die Beziehungen, sondern von besonderer Bedeutung ist des Weiteren der Bestand an Kreiliana in der Bibliothek Humboldts. Es handelt sich um neun Werke Kreils, das letzte aus dem Jahr 1856. Nachweisbare

  10. Effect of pregnancy on potency of bupivacaine for spinal anesthesia in rats%妊娠对大鼠布比卡因脊麻效力的影响

    Institute of Scientific and Technical Information of China (English)

    崔睿; 徐世元; 雷洪伊; 蔡清香; 王冬梅

    2010-01-01

    目的 探讨妊娠对大鼠布比卡因脊麻效力的影响.方法 雌性SD大鼠,非孕鼠体重180~220 g,孕鼠(孕17 d)体重350~400 g.取鞘内置管成功的非孕鼠及孕鼠各18只,非孕鼠随机分为3组(n=6):正常对照组(C组)、2%布比卡因组(B2组)及4%布比卡因组(B4组);孕鼠随机分为3组(n=6):对照组(PC组)、2%布比卡因组(PB2组)及4%布比卡因组(PB4组).C组与PC组:鞘内注射生理盐水30μl,其余4组相应鞘内分别注入2%或4%布比卡因30μl.分别于给药前(基础状态)、给药后10 min、20 min、30 min、1h、2 h、4 h、1 d、2 d、3 d和4 d时测定甩尾反应潜伏期,计算最大镇痛效应百分比(MPE);并进行后肢运动功能(MF)评分.结果 与基础值比较,B2组于给药后10 min~2 h时MPE升高,给药后10 min~1 h时MF评分升高;B4组于给药后10 min~4 h时MPE升高,给药后10 min~1 h时MF评分升高;PB2组于给药后10 min~1 d时MPE升高,给药后10 min~2 h时MF评分升高;PB4组于给药后10 min~1 d时MPE升高,给药后10 min~4 h时MF评分升高(P<0.05).结论 妊娠可增加大鼠布比卡因脊麻的效力.%Objective To investigate the effect of pregnancy on the potency of bupivacaine for spinal anesthesia in rats. Methods Female non-pregnant SD rats weighing 180-220 g and 17 day pregnant SD rats weighing 350-400 g were used in this study. The rats ( 18 non-pregnant, 18 pregnant) in which PE-10 catheter were successfully placed without complications were selected. The 18 non-pregnant rats were randomly divided into 3 groups (n =6 each): control group (group C), 2% bupivacaine group (group B2 ) and 4% bupivacaine group (group B4). The 18 pregnant rats were also randomly divided into 3 groups (n = 6 each): control group (group PC),2% bupivacaine group (group PB2 ) and 4% bupivacaine group (group PB4 ). Group C and PC received intrathecal (IT) normal saline 30 μl, and the other 4 groups received 2% or 4% bupivacaine 30 μl intrathecally. Analgesia was

  11. Werner Heisenberg. The language of the atoms. Life and work - a scientific biography - the ''joyous science'' (youth until Nobel price); Werner Heisenberg. Die Sprache der Atome. Leben und Wirken - Eine wissenschaftliche Biographie - Die ''froehliche Wissenschaft'' (Jugend bis Nobelpreis)

    Energy Technology Data Exchange (ETDEWEB)

    Rechenberg, Helmut [MPI fuer Physik, Muenchen (Germany). Werner-Heisenberg-Institut

    2010-07-01

    With his discovery that measuring values of complementary fundamental quantities in the microscopic world cannot by arbitrarily precisely determined cutted Werner Heisenberg the Gordian knot for the finishing of quantum theory developed by Planck, Einstein, and others and opened by this a new ''golden era'' in the physics of the 20th century. On the base of the documents from his life and work, i. e. deeds, letters and reports of contemporaries, as well as the published and unpublished essays, books, and articles of Heisenberg - also the later on found, publications or manuscripts mainly coming from the inheritance - resulted this systematic biography of Heisenberg. The author, the last doctoral candidate of Heisenberg relied furthermore on factual and personal knowledges, mainly own remembrances on his doctoral father and his teachers, colleagues, and students. Because of the interest of an authentical biography of the theoretical physicist Heisenberg the presentation of the mathematical approaches and the corresponding derivations could not completely be abandoned. This biography appeals by this both to a scientifically cultivated as a wider in science interested audience and covers the first phase of Heisenberg's life until his Nobel price 1933. [German] Mit seiner Entdeckung, dass sich Messwerte komplementaerer Groessen in der mikroskopischen Welt nicht beliebig genau bestimmen lassen, durchschnitt Werner Heisenberg den Gordischen Knoten zur Vollendung der von Planck, Einstein und anderen entwickelten Quantentheorie und eroeffnete damit ein neues ''goldenes Zeitalter'' in der Physik des 20. Jahrhunderts. Auf der Grundlage der Dokumente aus seinem Leben und Wirken, d.h. der Urkunden, Briefe und Berichte von Zeitzeugen sowie der publizierten und unpublizierten Abhandlungen, Buecher und Artikel Heisenbergs - auch der spaeter aufgefundenen, ueberwiegend aus dem Nachlass Heisenbergs stammenden Veroeffentlichungen oder

  12. Partial local thermal equilibrium in a low-temperature hydrogen plasma

    International Nuclear Information System (INIS)

    Hey, J.D.; Chu, C.C.; Rash, J.P.S.

    1999-01-01

    If the degree of ionisation is sufficient, competition between de-excitation by electron collisions and radiative decay determines the smallest principal quantum number (the so-called 'thermal limit') above which partial local thermodynamic equilibrium (PLTE) holds under the particular conditions of electron density and temperature. The LTE (PLTE) criteria of Wilson (JQSRT 1962;2:477-90), Griem (Phys Rev 1963;131:1170-6; Plasma Spectroscopy. New York: McGraw-Hill, 1964), Drawin (Z Physik 1969;228: 99-119), Hey (JQSRT 1976;16:69-75), and Fujimoto and McWhirter (Phys Rev A 1990;42:6588-601) are examined as regards their applicability to neutral atoms. For these purposes, we consider for simplicity an idealised, steady-state, homogeneous and primarily optically thin plasma, with some additional comments and numerical estimates on the roles of opacity and of atom-atom collisions. Particularly for atomic states of lower principal quantum number, the first two of the above criteria should be modified quite appreciably before application to neutral radiators in plasmas of low temperature, because of the profoundly different nature of the near-threshold collisional cross-sections for atoms and ions, while the most recent criterion should be applied with caution to PLTE of atoms in cold plasmas in ionisation balance. (Copyright (c) 1999 Elsevier Science B.V., Amsterdam. All rights reserved.)

  13. Electrical characterization of InAs thin films

    Energy Technology Data Exchange (ETDEWEB)

    Botha, L.; Shamba, P.; Botha, J.R. [Department of Physics, Nelson Mandela Metropolitan University, Port Elizabeth (South Africa)

    2008-07-01

    It is known that parallel conduction as a result of surface and /or interface charge accumulation significantly shields the bulk electrical properties of InAs thin films when characterized using Hall measurements. This parallel conduction in InAs can be modeled by using the two-layer model of Nedoluha and Koch [Zeitschrift fuer Physik 132, 608 (1952)]; where an InAs epilayer is treated as consisting of two conductors connected in parallel viz. a bulk and a surface layer. Here, this two-layer model is used to simulate Hall coefficient and conductivity data of InAs thin films ranging from strongly n-doped (n=10{sup 18} cm{sup -3}) to strongly p-doped (p{proportional_to}10{sup 19} cm{sup -3}) material. Conventional Hall approximations, i.e. those that assume uniform conduction from a single band, are then used to predict the apparent carrier concentration and mobility that will be determined from conventional Hall measurements, with the aim of illustrating the error of such a simplified analysis of InAs Hall data. Results show that, in addition to ignoring parallel conduction, the approximations of conventional Hall data analysis have a further inadequacy for p-type InAs, in that the high electron to hole mobility ratio in InAs is not taken into account. (copyright 2008 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  14. A novel instrument for generating angular increments of 1 nanoradian

    Science.gov (United States)

    Alcock, Simon G.; Bugnar, Alex; Nistea, Ioana; Sawhney, Kawal; Scott, Stewart; Hillman, Michael; Grindrod, Jamie; Johnson, Iain

    2015-12-01

    Accurate generation of small angles is of vital importance for calibrating angle-based metrology instruments used in a broad spectrum of industries including mechatronics, nano-positioning, and optic fabrication. We present a novel, piezo-driven, flexure device capable of reliably generating micro- and nanoradian angles. Unlike many such instruments, Diamond Light Source's nano-angle generator (Diamond-NANGO) does not rely on two separate actuators or rotation stages to provide coarse and fine motion. Instead, a single Physik Instrumente NEXLINE "PiezoWalk" actuator provides millimetres of travel with nanometre resolution. A cartwheel flexure efficiently converts displacement from the linear actuator into rotary motion with minimal parasitic errors. Rotation of the flexure is directly measured via a Magnescale "Laserscale" angle encoder. Closed-loop operation of the PiezoWalk actuator, using high-speed feedback from the angle encoder, ensures that the Diamond-NANGO's output drifts by only ˜0.3 nrad rms over ˜30 min. We show that the Diamond-NANGO can reliably move with unprecedented 1 nrad (˜57 ndeg) angular increments over a range of >7000 μrad. An autocollimator, interferometer, and capacitive displacement sensor are used to independently confirm the Diamond-NANGO's performance by simultaneously measuring the rotation of a reflective cube.

  15. Two- and three-particle azimuthal correlations of high-p{sub t} charged hadrons in Pb+Au collisons at 158 GeV per nucleon

    Energy Technology Data Exchange (ETDEWEB)

    Kniege, Stefan

    2009-07-14

    An essential goal of physics with heavy ions is the study of the state of nuclear matter at high densities respectively temperatures. Such states can be generated and studied by collisions of high-energetic heavy ions in particle accelerators like the Super Proton Synchrotron SPS at the European nuclear research center CERN in Geneve. The present thesis deals with the analysis of the influence of the medium generated in such a collision on high-energetic particles, which pass this medium. For this correlations between particles with high transverse momentum p{sub t} as function of the centrality of the collisions and the charge of the contributing particles are studied. Aim is to establish an experimental base for the theoretical description of the properties of the medium in such collisions. [German] Ein wesentliches Ziel der Physik mit schweren Ionen ist die Untersuchung der Zustaende von Kernmaterie bei hohen Dichten bzw. Temperaturen. Solche Zustaende lassen sich durch Kollisionen von hochenergetischen schweren Ionen in Teilchenbeschleunigern wie dem Super Proton Synchrotron SPS am Europaeischen Kernforschungszentrum CERN in Genf erzeugen und untersuchen. Die vorliegende Arbeit beschaeftigt sich mit der Analyse des Einflusses des in einer solchen Kollision erzeugten Mediums auf hochenergetische Teilchen, welche dieses Medium durchqueren. Hierzu werden Korrelationen zwischen Teilchen mit hohem Transversalimpuls p{sub t} als Funktion der Zentralitaet der Kollisionen und der Ladung der beteiligten Teilchen untersucht. Ziel ist es, hierdurch eine experimentelle Grundlage fuer die theoretische Beschreibung der Eigenschaften des Mediums in solchen Kollisionen bereitzustellen. (orig.)

  16. Spectroscopic studies on technetium and silicon. A solid-state laser system for the resonance-ionization spectroscopy; Spektroskopische Untersuchungen an Technetium und Silizium. Ein Festkoerperlasersystem fuer die Resonanzionisationsspektroskopie

    Energy Technology Data Exchange (ETDEWEB)

    Mattolat, Christoph

    2010-11-15

    This doctoral thesis describes advancement and refinement of the titanium:sapphire laser system of the working group LARISSA, Institut fuer Physik, Johannes Gutenberg- Universitaet Mainz and its application to resonance ionization spectroscopy. Activities on the laser systems comprised three major tasks: The output power of the conventional titanium:sapphire lasers could be increased by a factor of two in order to match the needs at resonance ionization laser ion source at ISOL facilities. Additionally, the laser system was complemented by a titanium:sapphire laser in Littrow geometry, which ensures a mode-hop free tuning range from 700 nm to 950 nm, and by an injection seeded titanium:sapphire laser with a spectral width of 20 MHz (in respect to a spectral width of 3 GHz for the conventional lasers). The performance of the new laser system was tested in spectroscopic investigations of highly excited atomic levels of gold and technetium. From the measured level positions the ionization potential of gold could be verified by using the Rydberg-Ritz formula, while the ionization potential of technetium could be determined precisely for the first time. Using the seeded titanium: sapphire laser Doppler-free two-photon spectroscopy inside a hot ionizer cavity was demonstrated. A width of the recorded resonances of 90 MHz was achieved and the hyperfine structure and isotope shift of stable silicon isotopes was well resolved with this method. (orig.)

  17. 120 YEARS SINCE THE DISCOVERY OF X-RAYS.

    Science.gov (United States)

    Babic, Rade R; Stankovic Babic, Gordana; Babic, Strahinja R; Babic, Nevena R

    2016-09-01

    This paper is intended to celebrate the 120th anniversary of the discovery of X-rays. X-rays (Roentgen-rays) were discovered on the 8th ofNovember, 1895 by the German physicist Wilhelm Conrad Roentgen. Fifty days after the discovery of X-ray, on December 28, 1895. Wilhelm Conrad Roentgen published a paper about the discovery of X-rays - "On a new kind of rays" (Wilhelm Conrad Roentgen: Ober eine neue Art von Strahlen. In: Sitzungsberichte der Wurzburger Physik.-Medic.- Gesellschaft. 1895.). Therefore, the date of 28th ofDecember, 1895 was taken as the date of X-rays discovery. This paper describes the work of Wilhelm Conrad Roentgen, Nikola Tesla, Mihajlo Pupin and Maria Sklodowska-Curie about the nature of X-rays . The fantastic four - Wilhelm Conrad Roentgen, NikolaTesla, Mihajlo ldvorski Pupin and Maria Sklodowska-Curie set the foundation of radiology with their discovery and study of X-rays. Five years after the discovery of X-rays, in 1900, Dr Avram Vinaver had the first X-ray machine installed in abac, in Serbia at the time when many developed countries did not have an X-ray machine and thus set the foundation of radiology in Serbia.

  18. Biokompatible Metalle

    Science.gov (United States)

    Ha, Suk-Woo; Wintermantel, Erich

    Metalle als Implantatwerkstoffe werden in der Medizin für zwei Hauptanwendungen eingesetzt: für Prothesen des totalen Gelenkersatzes wie beispielsweise Hüft-, Knie- und Schulterprothesen und für Fixationselemente zur Stabilisierung von Frakturen. Beispiele hierfür sind Osteosyntheseplatten, Marknägel, Schrauben, Drähte und Stents. Eine der ersten Anwendungen von Metallen im menschlichen Körper war die Fixation von Fragmenten eines gebrochenen Humerus (Oberarmknochen) mit einem Metalldraht durch zwei französische Physiker im Jahr 1775 [1]. Ausführliche Untersuchungen zur Verträglichkeit von Metallen im menschlichen Körper wurden bereits im frühen 19. Jahrhundert durchgeführt. Von den untersuchten Werkstoffen verursachten die edlen Metalle wie Gold, Silber und Platin aufgrund ihrer Korrosionsbeständigkeit und Körperverträglichkeit die geringsten Reizungen im menschlichen Körper. Die klinische Anwendung der Edelmetalle war jedoch wegen der geringen mechanischen Eigenschaften beschränkt. Andere Metalle wie Messing, Kupfer oder Eisen wiesen vergleichsweise höhere Festigkeitswerte auf, sie waren jedoch aufgrund der geringen Korrosionsbeständigkeit und Biokompatibilität nicht für den klinischen Einsatz geeignet. Ein weiteres Problem stellte die Gefahr der Infektion durch unsterile Instrumente und Implantate dar. Gegen Ende des 19. Jahrhunderts hielt die antiseptische Operationsmethode Einzug in die Kliniken, die z. B. erfolgreiche Operationen mit Silberdraht ermöglichte.

  19. Phasenübergänge

    Science.gov (United States)

    Heintze, Joachim

    Bisher haben wir nur das thermische Verhalten von Stoffen einheitlicher Konsistenz diskutiert. Eines der auffälligsten Phänomene in der Physik der Wärme ist aber, dass ein Stoff in verschiedenen Aggregatzuständen vorliegen kann: fest, flüssig oder gasförmig, und dass durch Wärmezufuhr und -abfuhr Übergänge zwischen diesen verschiedenen Phasen bewirkt werden. Zunächst werden wir die Phasenübergänge flüssig-gasförmig und fest-gasförmig ausführlich diskutieren. Dann zeigen wir, dass der Phasenübergang fest-flüssig auf ganz ähnliche Weise beschrieben werden kann. Eine zusammenfassende Darstellung der Phasenübergänge ist in der Form von Zustandsdiagrammen möglich. Die Untersuchung solcher Diagramme führt auf das interessante Phänomen des kritischen Punktes. Am Schluss des Kapitels betrachten wir Phasenübergänge in Zweistoffsystemen. Sie weisen einige Eigenschaften auf, die nicht nur merkwürdig und physikalisch interessant, sondern vor allem auch technisch von Bedeutung sind.

  20. Elements of quantum information

    International Nuclear Information System (INIS)

    Schleich, W.P.

    2007-01-01

    Elements of Quantum Information introduces the reader to the fascinating field of quantum information processing, which lives on the interface between computer science, physics, mathematics, and engineering. This interdisciplinary branch of science thrives on the use of quantum mechanics as a resource for high potential modern applications. With its wide coverage of experiments, applications, and specialized topics - all written by renowned experts - Elements of Quantum Information provides and indispensable, up-to-date account of the state of the art of this rapidly advancing field and takes the reader straight up to the frontiers of current research. The articles have first appeared as a special issue of the journal 'Fortschritte der Physik / Progress of Physics'. Since then, they have been carefully updated. The book will be an inspiring source of information and insight for anyone researching and specializing in experiments and theory of quantum information. Topics addressed in Elements of Quantum Information include - Cavity Quantum Electrodynamics - Segmented Paul Traps - Cold Atoms and Bose-Einstein Condensates in Microtraps, Optical Lattices, and on Atom Chips - Rydberg Gases - Factorization of Numbers with Physical Systems - Entanglement of Continuous Variables - NMR and Solid State Quantum Computation - Quantum Algorithms and Quantum Machines - Complexity Theory - Quantum Crytography. (orig.)

  1. Influence of clouds on earth climate. Modellings, measurements, and data analyses within the framework of an interconnected project; Einfluss von Wolken auf das Klima der Erde. Modellierungen, Messungen, Datenanalysen im Rahmen eines Verbundprojektes

    Energy Technology Data Exchange (ETDEWEB)

    Grassl, H; Raschke, E

    1995-11-01

    At the beginning of the project there was considerable uncertainty as to the influence of clouds of all kinds on the energy budget of the atmosphere, the quantities and impact of aerosols, and, especially, the physics of high curl clouds. There was neither a possibility to model such cloud systems, nor did reliable measuring methods exist. This interconnected project contributed to the solution of these problems with the aim to create a solid basis of work for future climate researches. Simultaneously, measurements were carried out, satellite data analysed, aerosol data by different authors compiled and evaluated, and numerical simulations of cloud sheets carried out. (orig.) [Deutsch] Zu Beginn des Vorhabens herrschten erhebliche Unsicherheiten ueber den Einfluss von Wolken aller Arten auf den Energiehaushalt der Atmosphaere, ueber die Mengen und Wirkungen des Aerosols - und insbesondere ueber die Physik der hohen Cirren. Es gab keine Modelliermoeglichkeiten fuer solche Wolkensysteme - noch existierten zuverlaessige Messmoeglichkeiten. Das Verbundvorhaben sollte zur Loesung dieser Probleme beitragen mit dem Ziel, eine solide Arbeitsbasis fuer zukuenftige Aufgaben der Klimaforschung zu schaffen. Es wurden gleichzeitig Messungen durchgefuehrt, Satellitendaten analysiert, Aerosoldaten unterschiedlicher Autoren zusammengetragen und geprueft sowie numerische Simulationen von Wolkenfeldern durchgefuehrt. (orig.)

  2. The structure of physics

    CERN Document Server

    Von Weizsäcker, Carl Friedrich; Lyre, Holger

    2006-01-01

    Carl Friedrich von Weizsäcker‘s "Aufbau der Physik", first published in 1985, was intended as an overview of his lifelong concern: an understanding of the unity of physics. That is, the idea of a quantum theory of binary alternatives (the so-called ur-theory), a unified quantum theoretical framework in which spinorial symmetry groups are considered to give rise to the structure of space and time. The book saw numerous reprints, but it was published in German only. The present edition, in English, provides a newly arranged and revised version, in which some original chapters and sections have been deleted, and a new chapter about further insights and results of ur-theoretic research of the late 1980’s and 1990’s, mainly by the work of Thomas Görnitz, has been included, as well as a general introduction to Weizsäcker’s Philosophy of Physics. Carl Friedrich von Weizsäcker also enjoys high esteem by a much broader audience for his socio-cultural, political and religious thoughts and writings. In him t...

  3. Constructive role of Brownian motion: Brownian motors and Stochastic Resonance

    Science.gov (United States)

    Hänggi, Peter

    2005-03-01

    Noise is usually thought of as the enemy of order rather as a constructive influence. For the phenomena of Stochastic Resonance [1] and Brownian motors [2], however, stochastic noise can play a beneficial role in enhancing detection and/or facilitating directed transmission of information in absence of biasing forces. Brownian motion assisted Stochastic Resonance finds useful applications in physical, technological, biological and biomedical contexts [1,3]. The basic principles that underpin Stochastic Resonance are elucidated and novel applications for nonlinear classical and quantum systems will be addressed. The presence of non-equilibrium disturbances enables to rectify Brownian motion so that quantum and classical objects can be directed around on a priori designed routes in biological and physical systems (Brownian motors). In doing so, the energy from the haphazard motion of (quantum) Brownian particles is extracted to perform useful work against an external load. This very concept together with first experimental realizations are discussed [2,4,5]. [1] L. Gammaitoni, P. Hä'nggi, P. Jung and F. Marchesoni, Stochastic Resonance, Rev. Mod. Phys. 70, 223 (1998).[2] R. D. Astumian and P. Hä'nggi, Brownian motors, Physics Today 55 (11), 33 (2002).[3] P. Hä'nggi, Stochastic Resonace in Physics and Biology, ChemPhysChem 3, 285 (2002).[4] H. Linke, editor, Special Issue on Brownian Motors, Applied Physics A 75, No. 2 (2002).[5] P. Hä'nggi, F. Marchesoni, F. Nori, Brownian motors, Ann. Physik (Leipzig) 14, xxx (2004); cond-mat/0410033.

  4. Supraleitung Grundlagen und Anwendungen

    CERN Document Server

    Buckel, Werner

    2013-01-01

    Grundlegende Konzepte und Eigenschaften von Supraleitern, die Herstellung und Entwicklung von neuen supraleitenden Materialien sowie moderne Anwendungsbereiche sind die Schwerpunktthemen des Buches. Das größte Potential zur Nutzung der Supraleitung liegt in der Energietechnik. Fast unbemerkt trägt die Einführung von Kabeln, Magneten, Transformatoren oder Lagern aus supraleitenden Materialien bei zur Effizienzsteigerung bei der Stromübertragung oder in Motoren. Durch seiner klare Sprache und zahlreiche erläuternde Abbildungen eignet sich der Band hervorragend als einführendes Lehrbuch. Der Schwierigkeitsgrad wird von Kapitel zu Kapitel gesteigert. So können auch Einsteiger ohne einschlägige Vorkenntnisse dem Stoff folgen. Dank der über 350 Literaturhinweise bekommt der Leser außerdem einen Überblick über die wichtigsten Publikationen zum Thema. Ein unverzichtbares Lehrbuch also für Physik-Studenten und Studierende der Ingenieurwissenschaften. Fachleuten in Forschung und Praxis leistet das Buch au...

  5. Digital Medien im Naturwissenschaftlichen Unterricht

    CERN Document Server

    Meßinger-Koppelt, Jenny

    2014-01-01

    „Morgens, 8 Uhr: Kurz vor der Schultür werden noch die neuesten Posts auf Facebook geliked, ein Selfie in die Whats-App-Gruppe hochgeladen oder auf YouTube noch ein #LOL-Video gestreamed. Dann klingelt es und die Digital Natives greifen wieder zu Stift, Papier und werden frontal mit Fakten gefüttert“ (A. Spang). Für Schüler sind Internet, Smartphone und Tablet-PC heute selbstverständlicher Teil ihrer Lernwelt. Und auch die Alltags- und Berufswelt ist ohne Informationstechnologien nicht mehr vorstellbar. Doch was bedeutet das für den Schulunterricht, insbesondere für die techniknahen Naturwissenschaften? Wie gelingt im Schulalltag die Balance zwischen Kreidezeit und interaktivem Whiteboard nach mittlerweile 30 Jahren Erfahrung mit Schulcomputern? Der vorliegende Sammelband präsentiert zahlreiche Praxisbeispiele aus dem Schulalltag zum sinnvollen Einsatz digitaler Medien im Biologie-, Chemie- und Physik-Unterricht sowie den aktuellen Stand der fachdidaktischen Forschung. Zu Wort kommen Hochschullehr...

  6. Medical physics 1981

    International Nuclear Information System (INIS)

    Bunde, E.

    1982-01-01

    This volume continues the series of congress publications with which the Deutsche Gesellschaft fuer Medizinische Physik has been completely documenting its annual meetings for some years. The meeting was aimed to show the complexity not only of the scientific specialty medical physics but also of the practical activities of medical physicists, or at least give some idea of it. The conference was centred on the following points: Possibilities of optimization and methods for re-examination of techniques used in X-ray diagnostics, nuclear diagnostics and ultrasonographic diagnostics; bases of dosimetry in practical radiotherapy, especially with a view to the plans to make gauging of therapeutical dosemeters compulsory; current state of neutron therapy and dosimetry; safety and constancy of irradiation devices in operation; planning and equipment of modern radiotherapy departments. Furthermore topics from medical optics and nuclearbiological research were dealt with. Reports were given on the clinical use of whole-body counters. Climatology and surgical research were marginally dealt with in two synoptical papers. Short reports on work currently under way completed the subject groups given and allowed insight into further topical fields of work of medical physicists in science and practice. Finally, the question of education received particular interest. (orig./MG) [de

  7. Radiative transfer modeling through terrestrial atmosphere and ocean accounting for inelastic processes: Software package SCIATRAN

    Science.gov (United States)

    Rozanov, V. V.; Dinter, T.; Rozanov, A. V.; Wolanin, A.; Bracher, A.; Burrows, J. P.

    2017-06-01

    SCIATRAN is a comprehensive software package which is designed to model radiative transfer processes in the terrestrial atmosphere and ocean in the spectral range from the ultraviolet to the thermal infrared (0.18-40 μm). It accounts for multiple scattering processes, polarization, thermal emission and ocean-atmosphere coupling. The main goal of this paper is to present a recently developed version of SCIATRAN which takes into account accurately inelastic radiative processes in both the atmosphere and the ocean. In the scalar version of the coupled ocean-atmosphere radiative transfer solver presented by Rozanov et al. [61] we have implemented the simulation of the rotational Raman scattering, vibrational Raman scattering, chlorophyll and colored dissolved organic matter fluorescence. In this paper we discuss and explain the numerical methods used in SCIATRAN to solve the scalar radiative transfer equation including trans-spectral processes, and demonstrate how some selected radiative transfer problems are solved using the SCIATRAN package. In addition we present selected comparisons of SCIATRAN simulations with those published benchmark results, independent radiative transfer models, and various measurements from satellite, ground-based, and ship-borne instruments. The extended SCIATRAN software package along with a detailed User's Guide is made available for scientists and students, who are undertaking their own research typically at universities, via the web page of the Institute of Environmental Physics (IUP), University of Bremen: http://www.iup.physik.uni-bremen.de.

  8. Upgrade to the control system of the reflectometry diagnostic of ASDEX upgrade

    International Nuclear Information System (INIS)

    Graca, S.; Santos, J.; Manso, M.E.

    2004-01-01

    The broadband frequency modulation-continuous wave microwave/millimeter wave reflectometer of ASDEX upgrade tokamak (Institut fuer Plasma Physik (IPP), Garching, Germany) developed by Centro de Fusao Nuclear (Lisboa, Portugal) with the collaboration of IPP, is a complex system with 13 channels (O and X modes) and two types of operation modes (swept and fixed frequency). The control system that ensures remote operation of the diagnostic incorporates VME and CAMAC bus based acquisition/timing systems. Microprocessor input/output boards are used to control and monitor the microwave circuitry and associated electronic devices. The implementation of the control system is based on an object-oriented client/server model: a centralized server manages the hardware and receives input from remote clients. Communication is handled through transmission control protocol/internet protocol sockets. Here we describe recent upgrades of the control system aiming to: (i) accommodate new channels; (ii) adapt to the heterogeneity of computing platforms and operating systems; and (iii) overcome remote access restrictions. Platform and operating system independence was achieved by redesigning the graphical user interface in JAVA. As secure shell is the standard remote access protocol adopted in major fusion laboratories, secure shell tunneling was implemented to allow remote operation of the diagnostic through the existing firewalls

  9. Quantenfische die Stringtheorie und die Suche nach Weltformel

    CERN Document Server

    Lüst, Dieter

    2011-01-01

    Lässt sich das Verhalten aller Dinge, von den kleinsten Teilchen bis zum Universum, einheitlich beschreiben? Der heißeste Kandidat für die Entwicklung einer Weltformel, die alle physikalischen Phänomene erklären kann, ist die Stringtheorie. Sollte sie sich als richtig erweisen, so würde das unser Verständnis über den Ursprung der Naturgesetze dramatisch verändern. Denn das von uns beobachtete Universum wäre dann vermutlich eine winzige Blase in einem viel größeren Gebilde, dem Multiversum. Um die Stringtheorie und die Idee des Multiversums plausibel zu machen, greift der international bekannte theoretische Physiker Dieter Lüst auf ein Modell zurück: das Leben von Fischen in einem Teich. Eines Tages gelingt es den Fischen, die kleinsten Teilchen zu identifizieren, aus denen alles im Fischteich besteht - eingeschlossen sie selbst. Sie nennen diese Urbausteine Quantenfische, da ihr Verhalten nahelegt, dass sie auch eine Art von Lebewesen sind. Doch der ersten folgt eine weitere Entdeckung der Fisch...

  10. Teilchendetektoren Grundlagen und Anwendungen

    CERN Document Server

    Kolanoski, Hermann

    2016-01-01

    In diesem Buch werden die experimentellen Grundlagen von Teilchendetektoren und ihre Anwendung in Experimenten beschrieben. Die Entwicklung von Detektoren ist ein wichtiger Bestandteil der Teilchen-, Astroteilchen- und Kernphysik und gehört daher zum Handwerk des Experimentalphysikers in diesen Gebieten. Dieses umfassende Werk beinhaltet den kompletten Stoff für entsprechende Master-Module in der experimentellen Teilchenphysik, geht aber im Inhalt auch darüber hinaus. Zielgruppe sind Studierende, die sich in die Materie vertiefen möchten, aber auch Lehrende und Wissenschaftler, die das Buch zum Einstieg in das wissenschaftliche Arbeiten an Detektorentwicklungen verwenden können. Zielrichtung des Buches ist, die physikalischen Grundlagen für die Detektoren und ihrer verschiedenen Ausführungen so klar wie möglich und so tiefgehend wie nötig darzustellen. Die Breite des für die Detektorentwicklung nötigen Wissens umfasst viele Bereiche der Physik und Technik, von den Wechselwirkun...

  11. Identifikationsverfahren zur Analyse von EEG-Signalen bei Epilepsie mit Reaktions-Diffusions Netzwerken

    Science.gov (United States)

    Gollas, F.; Tetzlaff, R.

    2007-06-01

    Partielle Differentialgleichungen des Reaktions-Diffusions-Typs beschreiben Phänomene wie Musterbildung, nichtlineare Wellenausbreitung und deterministisches Chaos und werden oft zur Untersuchung komplexer Vorgänge auf den Gebieten der Biologie, Chemie und Physik herangezogen. Zellulare Nichtlineare Netzwerke (CNN) sind eine räumliche Anordnung vergleichsweise einfacher dynamischer Systeme, die eine lokale Kopplung untereinander aufweisen. Durch eine Diskretisierung der Ortsvariablen können Reaktions-Diffusions-Gleichungen häufig auf CNN mit nichtlinearen Gewichtsfunktionen abgebildet werden. Die resultierenden Reaktions-Diffusions-CNN (RD-CNN) weisen dann in ihrer Dynamik näherungsweise gleiches Verhalten wie die zugrunde gelegten Reaktions-Diffusions-Systeme auf. Werden RD-CNN zur Identifikation neuronaler Strukturen anhand von EEG-Signalen herangezogen, so besteht die Möglichkeit festzustellen, ob das gefundene Netzwerk lokale Aktivität aufweist. Die von Chua eingeführte Theorie der lokalen Aktivität Chua (1998); Dogaru und Chua (1998) liefert eine notwendige Bedingung für das Auftreten von emergentem Verhalten in zellularen Netzwerken. Änderungen in den Parametern bestimmter RD-CNN könnten auf bevorstehende epileptische Anfälle hinweisen. In diesem Beitrag steht die Identifikation neuronaler Strukturen anhand von EEG-Signalen durch Reaktions-Diffusions-Netzwerke im Vordergrund der dargestellten Untersuchungen. In der Ergebnisdiskussion wird insbesondere auch die Frage nach einer geeigneten Netzwerkstruktur mit minimaler Komplexität behandelt.

  12. Dwarfs standing on the shoulders of giants

    CERN Multimedia

    2008-01-01

    Did you know that you can consult articles from the first ever issues of the Zeitschrift für Physik published in 1920 and the Physical Review written in 1893 without even having to leave your office? The CERN Library now offers access to more historical texts than ever before. Jens Vigen, head of Scientific Information Service.Even in as dynamic a field as particle physics, today’s research relies on the results of the past and sometimes takes up old lines of thought again. Consulting old articles used to mean trawling through dusty old tomes in the library but these collections have now been brought into the digital era. Over the last decade, the CERN Library has built up a large collection of electronic archives, which are not confined to physics as the Library offers on-line access to all the journals and magazines published by the IEEE (Institute of Electrical and Electronics Engineers) and the associated archives. This yea...

  13. Manufacture of barium hexaferrite (BaO3.98Fe2O3) from iron oxide waste of grinding process by using calcination process

    Science.gov (United States)

    Idayanti, N.; Dedi; Kristiantoro, T.; Mulyadi, D.; Sudrajat, N.; Alam, G. F. N.

    2018-03-01

    The utilization of iron oxide waste of grinding process as raw materials for making barium hexaferrite has been completed by powder metallurgy method. The iron oxide waste was purified by roasting at 800 °C temperature for 3 hours. The method used varying calcination temperature at 1000, 1100, 1200, and 1250 °C for 3 hours. The starting iron oxide waste (Fe2O3) and barium carbonate (BaCO3) were prepared by mol ratio of Fe2O3:BaCO3 from the formula BaO3.98Fe2O3. Some additives such as calcium oxide (CaO), silicon dioxide (SiO2), and polyvinyl alcohol (PVA) were added after calcination process. The samples were formed at the pressure of 2 ton/cm2 and sintered at the temperature of 1250 °C for 1 hour. The formation of barium hexaferrite compounds after calcination is determined by X-Ray diffraction. The magnetic properties were observed by Permagraph-Magnet Physik with the optimum characteristic at calcination temperature of 1250 °C with the induction of remanence (Br) = 1.38 kG, coercivity (HcJ) = 4.533 kOe, product energy maximum (BHmax) = 1.086 MGOe, and density = 4.33 g/cm3.

  14. Die Entdeckung des Higgs-Teilchens oder wie das Universum seine Masse bekam

    CERN Document Server

    2013-01-01

    Im Oktober 2013 setzte der Nobelpreis für Peter Higgs und François Englert den vorläufigen Höhepunkt in der verrückten Geschichte um das sogenannte Gottesteilchen, das Higgs-Boson. Schon im Juli des Vorjahres hatten die Physiker weltweit gejubelt: Mehr als fünfzig Jahre nachdem Peter Higgs und andere Wissenschaftler die Existenz des Teilchens theoretisch begründet hatten, war es im gigantischen Teilchenbeschleuniger CERN gefunden worden. Jetzt erzählen Harald Lesch und seine Co-Autoren, warum sich rund um das Higgs-Teilchen so viele skurrile Missverständnisse und mediale Sensationen ranken. Gewohnt kurzweilig und gut verständlich enthüllen sie, wie aus dem verzweifelt gesuchten „gottverdammten Teilchen“ das Gottesteilchen wurde, dass der Urknall nicht simuliert werden kann und dass Schwarze Löcher nicht unbedingt alles verschlingende Monster sind. Dabei wird deutlich, dass die Suche nach den geheimnisvollen Kräften, die das Universum, unsere Erde und letztlich auch uns Menschen zusammenhalten...

  15. Geneva University

    CERN Multimedia

    2010-01-01

    Ecole de physique Département de physique nucléaire et corspusculaire 24, quai Ernest-Ansermet 1211 GENEVE 4 Tel: (022) 379 62 73 Fax: (022) 379 69 92 Wednesday 14 April 2010 PARTICLE PHYSICS SEMINAR at 17.00 hrs – Stückelberg Auditorium Dark Matter and the XENON Experiment By Dr. Marc Schumann, Physik Institut, Universität Zürich There is convincing astrophysical and cosmological evidence that most of the matter in the Universe is dark: It is invisible in every band of the electromagnetic spectrum. Weakly interacting massive particles (WIMPs) are promising Dark Matter candidates that arise naturally in many theories beyond the Standard Model. Several experiments aim to directly detect WIMPs by measuring nuclear recoils from WIMPs scattered on target nuclei. In this talk, I will give an overview on Dark Matter and direct Dark Matter detection. Then I will focus on the XENON100 experiment, a 2-phase liquid/gas time projection chamber (TPC) that ...

  16. Einstein's Annalen Papers: The Complete Collection 1901 - 1922

    Science.gov (United States)

    Renn, Jürgen

    2005-05-01

    In 1905, Einstein's Annus Mirabilis, Albert Einstein made three discoveries concerning the foundations of nature which form the basis of his fame as a physicist. These revolutionary papers on the light-quantum hypothesis, Brownian motion, and special relativity, were published in the journal "Annalen der Physik". All three are now established as pillars of modern science and its applications in technology and are an indispensable part of the modern world. This volume presents some of the most significant original papers which Albert Einstein ever wrote. It includes the facsimiles of the three revolutionary papers of 1905. In addition it contains papers which show the consequences of the ground-breaking ideas of these seminal papers from E=mc² to the quantum theory of specific heats. It also features Einstein's first exposition of his new general theory of relativity. Introducing the original German papers the science historians Jürgen Renn (MPI for the History of Science, Berlin), David C. Cassidy (Hofstra University, Hempstead), Michel Janssen (University of Minnesota), and Robert Rynasiewicz (John Hopkins University) complement and comment the collection with topical articles.

  17. Einstein and Planck

    Science.gov (United States)

    Heilbron, John

    2005-03-01

    As an editor of the Annalen der Physik, Max Planck published Einstein's early papers on thermodynamics and on special relativity, which Planck probably was the first major physicist to appreciate. They respected one another not only as physicists but also, for their inspired creation of world pictures, as artists. Planck helped to establish Einstein in a sinecure at the center of German physics, Berlin. Despite their differences in scientific style, social life, politics, and religion, they became fast friends. Their mutual admiration survived World War I, during which Einstein advocated pacifism and Planck signed the infamous Manifesto of the 93 Intellectuals supporting the German invasion of Belgium. It also survived the Weimar Republic, which Einstein favored and Planck disliked. Physics drew them together, as both opposed the Copenhagen Interpretation; so did common decency, as Planck helped to protect Einstein from anti-semitic attacks. Their friendship did not survive the Nazis. As a standing secretary of the Berlin Academy, Planck had to advise Einstein to resign from it before his colleagues, outraged at his criticism of the new Germany from the safety of California, expelled him. Einstein never forgave his old friend and former fellow artist for not protesting publicly against his expulsion and denigration, and other enormities of National Socialism. .

  18. Development of thin sensors and a novel interconnection technology for the upgrade of the ATLAS pixel system

    Energy Technology Data Exchange (ETDEWEB)

    Andricek, L. [Max-Planck-Institut Halbleiterlabor, Otto Hahn Ring 6, 81739 Muenchen (Germany); Beimforde, M., E-mail: mibei@mpp.mpg.de [Max-Planck-Institut fuer Physik, Foehringer Ring 6, 80805 Muenchen (Germany); Macchiolo, A. [Max-Planck-Institut fuer Physik, Foehringer Ring 6, 80805 Muenchen (Germany); Moser, H.-G. [Max-Planck-Institut Halbleiterlabor, Otto Hahn Ring 6, 81739 Muenchen (Germany); Nisius, R. [Max-Planck-Institut fuer Physik, Foehringer Ring 6, 80805 Muenchen (Germany); Richter, R.H. [Max-Planck-Institut Halbleiterlabor, Otto Hahn Ring 6, 81739 Muenchen (Germany)

    2011-04-21

    A new pixel module concept is presented utilizing thin sensors and a novel vertical integration technique for the ATLAS pixel detector in view of the foreseen LHC luminosity upgrades. A first set of pixel sensors with active thicknesses of 75 and 150{mu}m has been produced from wafers of standard thickness using a thinning process developed at the Max-Planck-Institut Halbleiterlabor (HLL) and the Max-Planck-Institut fuer Physik (MPP). Pre-irradiation characterizations of these sensors show a very good device yield and high break down voltage. First proton irradiations up to a fluence of 10{sup 15} n{sub eq} cm{sup -2} have been carried out and their impact on the electrical properties of thin sensors has been studied. The novel ICV-SLID vertical integration technology will allow for routing signals vertically to the back side of the readout chips. With this, four-side buttable detector devices with an increased active area fraction are made possible. A first production of SLID test structures was performed and showed a high connection efficiency for different pad sizes and a mild sensitivity to disturbances of the surface planarity.

  19. Development of thin sensors and a novel interconnection technology for the upgrade of the ATLAS pixel system

    International Nuclear Information System (INIS)

    Andricek, L.; Beimforde, M.; Macchiolo, A.; Moser, H.-G.; Nisius, R.; Richter, R.H.

    2011-01-01

    A new pixel module concept is presented utilizing thin sensors and a novel vertical integration technique for the ATLAS pixel detector in view of the foreseen LHC luminosity upgrades. A first set of pixel sensors with active thicknesses of 75 and 150μm has been produced from wafers of standard thickness using a thinning process developed at the Max-Planck-Institut Halbleiterlabor (HLL) and the Max-Planck-Institut fuer Physik (MPP). Pre-irradiation characterizations of these sensors show a very good device yield and high break down voltage. First proton irradiations up to a fluence of 10 15 n eq cm -2 have been carried out and their impact on the electrical properties of thin sensors has been studied. The novel ICV-SLID vertical integration technology will allow for routing signals vertically to the back side of the readout chips. With this, four-side buttable detector devices with an increased active area fraction are made possible. A first production of SLID test structures was performed and showed a high connection efficiency for different pad sizes and a mild sensitivity to disturbances of the surface planarity.

  20. A module concept for the upgrades of the ATLAS pixel system using the novel SLID-ICV vertical integration technology

    CERN Document Server

    Beimforde, M; Macchiolo, A; Moser, H G; Nisius, R; Richter, R H; Weigell, P; 10.1088/1748-0221/5/12/C12025

    2010-01-01

    The presented R&D activity is focused on the development of a new pixel module concept for the foreseen upgrades of the ATLAS detector towards the Super LHC employing thin n-in-p silicon sensors together with a novel vertical integration technology. A first set of pixel sensors with active thicknesses of 75 μm and 150 μm has been produced using a thinning technique developed at the Max-Planck-Institut für Physik (MPP) and the MPI Semiconductor Laboratory (HLL). Charge Collection Efficiency (CCE) measurements of these sensors irradiated with 26 MeV protons up to a particle fluence of 1016neqcm−2 have been performed, yielding higher values than expected from the present radiation damage models. The novel integration technology, developed by the Fraunhofer Institut EMFT, consists of the Solid-Liquid InterDiffusion (SLID) interconnection, being an alternative to the standard solder bump-bonding, and Inter-Chip Vias (ICVs) for routing signals vertically through electronics. This allows for extracting the ...

  1. The Einstein almanac

    CERN Document Server

    Calaprice, Alice

    2005-01-01

    Albert Einstein was an exceptional human being. Perhaps nothing reflects the breadth and scope of his brilliance, his interests, and his influence better than his publications -- more than six hundred scientific papers, books, essays, reviews, and opinion pieces. Einstein began publishing in March 1901 with a scientific work that appeared in the German journal Annalen der Physik when he was twenty-two; the last publication was an editorial in the journal Common Cause which appeared a few months before his death in 1955. In the fifty-four-year interval, his published work ranged widely over relativity theory and quantum physics, nationalism, Judaism, war, peace, and education. Indeed, Einstein's literary output was so abundant that even many of his most informed admirers are not familiar with all of it. The Einstein Almanac takes a look at Einstein's year-by-year output, explaining his three-hundred most important publications and setting them into the context of his life, science, and world history. Concentr...

  2. Werner Heisenberg - Life and Work

    CERN Multimedia

    2002-01-01

    Werner Heisenberg (centre) with Wolfgang Pauli (left) and Enrico Fermi on Lake Como, September 1927. An exhibition on the life and work of Werner Heisenberg will be on display in the Main Building (Mezzanine) at CERN from 1 - 23 July. The exhibition was produced by the University Archive of Leipzig University (Gerald Wiemers) and the Max-Planck-Institut für Physik in Munich (Helmut Rechenberg) to mark the centenary of Heisenberg's birth in 1901. German theoretical physicist Werner Karl Heisenberg (5 December 1901 - 1 February 1976) was one of the leading scientists of the 20th century. He carried out important work in nuclear and particle physics, but his most significant contribution was to the development of quantum mechanics. He is best known for his uncertainty principle, which restricts the accuracy with which some properties of atoms and particles - such as position and linear momentum - can be determined simultaneously. In 1932 he was awarded the Noble Prize in Physics 'for the creation of q...

  3. Secrets of the old one Einstein, 1905

    CERN Document Server

    Bernstein, Jeremy

    2006-01-01

    In March 1905, at approximately eight week intervals, the Editor of the noted German physics journal, Annalen der Physik, received three hand-written manuscripts from a relatively unknown patent examiner in Bern, Switzerland. This patent examiner was the twenty-six year old Albert Einstein and the three papers would set the agenda for twentieth century physics. A fourth short paper was received in September 1905 and contained Einstein's derivation of the formula E=mc^2. These papers changed our lives in the twentieth century and beyond. While to a professional physicist the mathematics in these papers are quite straight forward, the ideas behind them are not. In fact, none of Einstein's contemporaries fully understood what he had done. In SECRETS OF THE OLD ONE: Einstein, 1905, renowned science writer Jeremy Bernstein makes these ideas accessible to a general reader with a limited background in mathematics. After reading this book, you will understand why 1905 is often designated as Einstein's miracle year.

  4. [Staffing levels in medical radiation physics in radiation therapy in Germany. Summary of a questionnaire].

    Science.gov (United States)

    Leetz, Hans-Karl; Eipper, Hermann Hans; Gfirtner, Hans; Schneider, Peter; Welker, Klaus

    2003-10-01

    To get a general idea of the actual staffing level situation in medical radiation physics in 1999 a survey was carried out by the task-group "Personalbedarf" of Deutsche Gesellschaft für Medizinische Physik (DGMP) among all DGMP-members who are active in this field. Main components for equipment and activities are defined in Report 8 and 10 of DGMP for staffing requirements in medical radiation physics. 322 forms were sent out, 173 of them have been evaluated. From the answers regarding equipment and activities numbers for staff are calculated by the methods given in Report 8 and 10 for this spot check target and compared with effective staffing levels. The data of the spot check are then extrapolated on total Germany. The result is a calculated deficit of 865 medical physicists for the whole physics staff, 166 of them in radiation therapy. From the age distribution of DGMP-members and the calculated deficit resulted a training capacity of about 100 medical physicists at all per year (19 in radiation therapy) if the deficit shall be cut back in 10 years.

  5. Upgrade to the control system of the reflectometry diagnostic of ASDEX upgrade

    Science.gov (United States)

    Graça, S.; Santos, J.; Manso, M. E.

    2004-10-01

    The broadband frequency modulation-continuous wave microwave/millimeter wave reflectometer of ASDEX upgrade tokamak (Institut für Plasma Physik (IPP), Garching, Germany) developed by Centro de Fusão Nuclear (Lisboa, Portugal) with the collaboration of IPP, is a complex system with 13 channels (O and X modes) and two types of operation modes (swept and fixed frequency). The control system that ensures remote operation of the diagnostic incorporates VME and CAMAC bus based acquisition/timing systems. Microprocessor input/output boards are used to control and monitor the microwave circuitry and associated electronic devices. The implementation of the control system is based on an object-oriented client/server model: a centralized server manages the hardware and receives input from remote clients. Communication is handled through transmission control protocol/internet protocol sockets. Here we describe recent upgrades of the control system aiming to: (i) accommodate new channels; (ii) adapt to the heterogeneity of computing platforms and operating systems; and (iii) overcome remote access restrictions. Platform and operating system independence was achieved by redesigning the graphical user interface in JAVA. As secure shell is the standard remote access protocol adopted in major fusion laboratories, secure shell tunneling was implemented to allow remote operation of the diagnostic through the existing firewalls.

  6. Wie man Elementarteilchen entdeckt vom Zyklotron zum LHC : ein Streifzug durch die Welt der Teilchenbeschleuniger

    CERN Document Server

    Freytag, Carl

    2016-01-01

    Dieses Buch erklärt die physikalischen Grundlagen und die Technologien der Elementarteilchenforschung und beschreibt allgemeinverständlich Teilchenbeschleuniger und -detektoren sowie ihr Zusammenspiel. An einigen Meilensteinen der Forschung – von der Erzeugung von Transuranen über die Entdeckung exotischer Mesonen bis zum Higgs-Boson – zeigen die Autoren den Weg von der Theorie über das Experiment zum Forschungsergebnis auf. Gravitonen, Higgs-Teilchen, Neutrinos und Quarks – das Interesse an den kleinsten uns bekannten Teilchen ist seit Jahrzehnten ungebrochen und rückt damit auch die Laboratorien in den Blick, die an die Grenzen der Physik vorstoßen: Neben dem größten Experimentierfeld, das wir haben – dem Universum selbst - sind es die gigantischen Maschinen der Elementarteilchenphysik in Großforschungseinrichtungen wie dem CERN und dem DESY. Mit ihnen versuchen Forscher weltweit unter Einsatz extrem hoher Energien Zustände zu simulieren, wie sie zum Beginn unseres Universums kurz nach d...

  7. Blackbody Radiation and the Loss of Universality: Implications for Planck's Formulation and Boltzman's Constant

    Directory of Open Access Journals (Sweden)

    Robitaille P.-M.

    2009-10-01

    Full Text Available Through the reevaluation of Kirchhoff's law (Robitaille P.M.L. IEEE Trans. Plasma Sci., 2003, v.31(6, 1263-1267, Planck's blackbody equation (Planck M. Ann. der Physik, 1901, v.4, 553-356 loses its universal significance and becomes restricted to perfect absorbers. Consequently, the proper application of Planck's radiation law involves the study of solid opaque objects, typically made from graphite, soot, and carbon black. The extension of this equation to other materials may yield apparent temperatures, which do not have any physical meaning relative to the usual temperature scales. Real temperatures are exclusively obtained from objects which are known solids, or which are enclosed within, or in equilibrium with, a perfect absorber. For this reason, the currently accepted temperature of the microwave background must be viewed as an apparent temperature. Rectifying this situation, while respecting real temperatures, involves a reexamination of Boltzman's constant. In so doing, the latter is deprived of its universal nature and, in fact, acts as a temperature dependent variable. In its revised form, Planck's equation becomes temperature insensitive near 300K, when applied to the microwave background.

  8. Feyerabend's 'The concept of intelligibility in modern physics' (1948).

    Science.gov (United States)

    Kuby, Daniel

    2016-06-01

    This essay introduces the transcription and translation of Paul Feyerabend's Der Begriff der Verständlichkeit in der modernen Physik [The concept of intelligibility in modern physics] (1948), which is an early essay written by Paul Feyerabend in 1948 on the topic of intelligibility (Verständlichkeit) and visualizability (Anschaulichkeit) of physical theories. The existence of such essay was likely. It is listed in his bibliography as his first publication. Yet the content of the essay was unknown, as no original or copy is extant in Feyerabend's Nachlass and no known published version was available to the community-until now. The essay has both historical and philosophical interest: it is, as far as our current knowledge goes, Feyerabend's earliest extant publication. It documents Feyerabend's philosophical interest as a physicist-to-be, in what he himself called his "positivist" phase; and it gives a rare if fragmentary insight into the early discussions of the 'Third Vienna Circle' and, more generally, the philosophical culture of discussion in Vienna. Copyright © 2015 Elsevier Ltd. All rights reserved.

  9. A Note on the Constitution of the Sun

    Directory of Open Access Journals (Sweden)

    Magnus H. G.

    2011-07-01

    Full Text Available Patrice Robitaille (TAV College, Montreal, Canada provides a translation of Heinrich Gustav Magnus’ classic work Notiz ̈uber die Beschaffenheit der Sonne , as it appeared in March 1864 within Poggendorff’s Annalen der Physik und Chemie ,1864, v.131, 510– 512. The article had previously been translated into French: Notice sur la constitution du soleil. Archives des science physique et naturelles (Gen`eve , 1864, v.20, 171–175. This work formed the basis of the present translation. Heinrich Gustav Magnus (May 2, 1802 – April 4, 1870 was a professor at the University of Berlin and had studied in Paris under Joseph Louis Gay-Lussac. He would count amongst his students Wil- helm Beetz, Hermann Helmholtz, Gustav Wiedemann, John Tyndall, Rudolph Weber, and Adolph W ̈ ullner (Heinrich Gustav Magnus, Platinum Metals Review , 1976, v.20(1, 21–24. In his Notiz , Magnus demonstrated that the addition of sodium hydroxide to the gaseous flame resulted in a tremendous increase in luminosity. Magnus’ work would inspire Father Secchi to propose that the Sun was a gaseous globe whose photosphere contained condensed particulate matter (Secchi A. Sulla Struttura della Fotosfera So- lare. Bulletino Meteorologico dell’ Osservatorio del Collegio Romano , 1864, v.3(11, 1–3; English translation in Progr. Phys. , 2011, v.3, 30–32. Magnus’ report on the constitution of the Sun would continue to impact solar physics for two generations.

  10. Electrical characterization of InAs thin films

    International Nuclear Information System (INIS)

    Botha, L.; Shamba, P.; Botha, J.R.

    2008-01-01

    It is known that parallel conduction as a result of surface and /or interface charge accumulation significantly shields the bulk electrical properties of InAs thin films when characterized using Hall measurements. This parallel conduction in InAs can be modeled by using the two-layer model of Nedoluha and Koch [Zeitschrift fuer Physik 132, 608 (1952)]; where an InAs epilayer is treated as consisting of two conductors connected in parallel viz. a bulk and a surface layer. Here, this two-layer model is used to simulate Hall coefficient and conductivity data of InAs thin films ranging from strongly n-doped (n=10 18 cm -3 ) to strongly p-doped (p∝10 19 cm -3 ) material. Conventional Hall approximations, i.e. those that assume uniform conduction from a single band, are then used to predict the apparent carrier concentration and mobility that will be determined from conventional Hall measurements, with the aim of illustrating the error of such a simplified analysis of InAs Hall data. Results show that, in addition to ignoring parallel conduction, the approximations of conventional Hall data analysis have a further inadequacy for p-type InAs, in that the high electron to hole mobility ratio in InAs is not taken into account. (copyright 2008 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  11. Ocular ultraviolet radiation exposure of welders.

    Science.gov (United States)

    Tenkate, Thomas D

    2017-05-01

    I read with interest a recent paper in your journal by Slagor et al on the risk of cataract in relation to metal arc welding (1). The authors highlight that even though welders are exposed to substantial levels of ultraviolet radiation (UVR), "no studies have reported data on how much UVR welders' eyes are exposed to during a working day. Thus, we do not know whether welders are more or less exposed to UVR than outdoor workers" (1, p451). Undertaking accurate exposure assessment of UVR from welding arcs is difficult, however, two studies have reported ocular/facial UVR levels underneath welding helmets (2, 3). In the first paper, UVR levels were measured using polysulphone film dosimeters applied to the cheeks of a patient who suffered from severe facial dermatitis (2). UVR levels of four times the American Conference of Governmental Industrial Hygienists (ACGIH) maximum permissible exposure (MPE) (4) were measured on the workers left cheek and nine times the MPE on the right cheek. The authors concluded that the workers dermatitis was likely to have been due to the UVR exposure received during welding. In the other paper, a comprehensive exposure assessment of personal UVR exposure of workers in a welding environment was reported (3). The study was conducted at a metal fabrication workshop with participants being welders, boilermakers and non-welders (eg, supervisors, fitters, machinists). Polysulphone film dosimeters were again used to measure UVR exposure of the workers, with badges worn on the clothing of workers (in the chest area), on the exterior of welding helmets, attached to 11 locations on the inside of welding helmets, and on the bridge and side-shields of safety spectacles. Dosimeters were also attached to surfaces throughout the workshop to measure ambient UVR levels. For welding subjects, mean 8-hour UVR doses within the welding helmets ranged from around 9 mJ/cm 2 (3×MPE) on the inside of the helmets to around 15 mJ/cm 2 (5×MPE) on the headband (a

  12. Naturkraft integration at Kaarstoe. Mapping study report 6 march 2009

    Energy Technology Data Exchange (ETDEWEB)

    Odland, Oeystein; Hoeie, Hans; Aanestad, Per; Hauge, Bjoern I.; Solvang, Svein; Boee, Stein Espen; Lervik, Steinar; Kristiansen, Arild

    2007-07-01

    Gassco is engaged in three different studies and projects related to reduce CO{sub 2} emissions at Kaarstoe; 1. Gassnova's CO{sub 2} capture, transport and storage projects at Kaarstoe and Mongstad (the CO{sub 2} Transportation Network), where Gassco role is to mature the transportation facilities of the project. An investment decision is planned for second half of 2009. 2. The Kaarstoe Flue Gas Capture pre-feasibility study initiated by the MPE to Gassco as operator of Gassled in connection with approval of the Kaarstoe Expansion Project 2010, to evaluate the potential of capturing the CO{sub 2} emissions at the Kaarstoe gas processing plant, and reported to the MPE 3 March 2009, and 3. This Naturkraft Integration Mapping Study initiated by MPE to meet the requirements set out by the letter to Gassco dated 3 December 2008 to evaluate possibilities to integrate existing Naturkraft's power plant with the Kaarstoe gas processing plant. In this Naturkraft Integration Study report Gassco has identified potential degrees of integration and resulting impact with respect to performance of both the Naturkraft power plant and the Kaarstoe gas processing plant. A major concern related to operations of the Kaarstoe gas processing plant is the regularity and availability issues related to natural gas and NGL export. The value of the petroleum transported over Kaarstoe on any day exceeds 200 million NOK. In addition also significant oil production will be shut down if the Kaarstoe gas processing plant is not operating. Hence the regularity of energy supply including steam is of utmost importance. The integration between Naturkraft and the gas processing plant is based on supplying energy (i.e. fuel gas, steam, heat and electricity) from Naturkraft's existing power plant, and therefore must be based on predictable and steady operations of the Naturkraft power plant. Naturkraft has only been in operation for a few weeks from the start-up of the power plant 1

  13. A NASA Strategy for Leveraging Emerging Launch Vehicles for Routine, Small Payload Missions

    Science.gov (United States)

    Underwood, Bruce E.

    2005-01-01

    Orbital flight opportunities for small payloads have always been few and far between, and then on February 1, 2002, the situation got worse. In the wake of the loss of the Columbia during STS- 107, changing NASA missions and priorities led to the termination of the Shuttle Small Payloads Projects, including Get-Away Special, Hitcbker, and Space Experiment Module. In spite of the limited opportunities, long queue, and restrictions associated with flying experiments on a man-rated transportation system; the carriers provided a sustained, high quality experiment services for education, science, and technology payloads, and was one of the few games in town. Attempts to establish routine opportunities aboard existing ELVs have been unsuccessful, as the cost-per-pound on small ELVs and conflicts with primary spacecraft on larger vehicles have proven prohibitive. Ths has led to a backlog of existing NASA-sponsored payloads and no prospects or plans for fbture opportunities within the NASA community. The prospects for breaking out of this paradigm appear promising as a result of NASA s partnership with DARPA in pursuit of low-cost, responsive small ELVs under the Falcon Program. Through this partnership several new small ELVs, providing 1000 lbs. to LEO will be demonstrated in less than two years that promise costs that are reasonable enough that NASA, DoD, and other sponsors can once again invest in small payload opportunities. Within NASA, planning has already begun. NASA will be populating one or more of the Falcon demonstration flights with small payloads that are already under development. To accommodate these experiments, Goddard s Wallops Flight Facility has been tasked to develop a multi-payload ejector (MPE) to accommodate the needs of these payloads. The MPE capabilities and design is described in detail in a separately submitted abstract. Beyond use of the demonstration flights however, Goddard has already begun developing strategies to leverage these new ELVs

  14. Establishment of A Malignant Pleural Effusion Mouse Model with Lewis Lung 
Carcinoma Cell Lines Expressing Enhanced Green Fluorescent Protein

    Directory of Open Access Journals (Sweden)

    Xingqun MA

    2012-06-01

    Full Text Available Background and objective Malignant pleural effusion (MPE is a poor prognosis factor in patients with advanced lung cancer. The aim of this study is to establish a mouse model of MPE using Lewis lung carcinoma (LLC cell lines expressing enhanced green fluorescent protein (EGFP. Methods The mouse model was created by injecting LLC-EGFP cells directly into the pleural cavity of mice that were sacrificed periodically. The dynamic growth and metastasis of tumor cells were screened using in vivo fluorescence imaging. The remaining mice were subjected to transverse computed tomography (CT imaging periodically to analyze the formation rate of pleural effusion. The survival rate and tumor metastasis were also observed. Pleural fluid was gently aspirated using a 1 mL syringe and its volume was measured. When two or more mice bore pleural effusion at the same time, we calculated the average volume. The correlation of pleural effusion with the integrated optical density (IOD were analyzed. Results Four days after the inoculation of LLC-EGFP cells, green fluorescence was observed by opening the chest wall. The tumor formation rate was 100%, and the IOD gradually increased after inoculation. The metastasis sites were mediastinal, and the hilar lymph nodes were contralateral pleural as well as pericardial. The metastasis rates were 87%, 73% and 20%, respectively. The CT scan revealed that the formation rates of pleural effusion on days 7, 14 and 21 were 13%, 46% and 53%, respectively. The average volume of pleural effusion increased obviously on day 10 and peaked on day 16 with a value of 0.5 mL. The mean survival time of nude mice was 28.8 days. The volume of pleural effusion and IOD were significantly correlated (r=0.91, P<0.000,1. Conclusion A mouse model of lung cancer malignant pleural effusion was successfully established by injecting LLC lines expressing EGFP into the pleural cavity under a microscope. The model can enable dynamic observations of the

  15. Neuromuscular electrical stimulation prior to presleep protein feeding stimulates the use of protein-derived amino acids for overnight muscle protein synthesis.

    Science.gov (United States)

    Dirks, Marlou L; Groen, Bart B L; Franssen, Rinske; van Kranenburg, Janneau; van Loon, Luc J C

    2017-01-01

    Short periods of muscle disuse result in substantial skeletal muscle atrophy. Recently, we showed that both neuromuscular electrical stimulation (NMES) as well as presleep dietary protein ingestion represent effective strategies to stimulate muscle protein synthesis rates. In this study, we test our hypothesis that NMES can augment the use of presleep protein-derived amino acids for overnight muscle protein synthesis in older men. Twenty healthy, older [69 ± 1 (SE) yr] men were subjected to 24 h of bed rest, starting at 8:00 AM. In the evening, volunteers were subjected to 70-min 1-legged NMES, while the other leg served as nonstimulated control (CON). Immediately following NMES, 40 g of intrinsically l-[1- 13 C]-phenylalanine labeled protein was ingested prior to sleep. Blood samples were taken throughout the night, and muscle biopsies were obtained from both legs in the evening and the following morning (8 h after protein ingestion) to assess dietary protein-derived l-[1- 13 C]-phenylalanine enrichments in myofibrillar protein. Plasma phenylalanine concentrations and plasma l-[1- 13 C]-phenylalanine enrichments increased significantly following protein ingestion and remained elevated for up to 6 h after protein ingestion (P protein-bound l-[1- 13 C]-phenylalanine enrichments (MPE) increased to a greater extent in the stimulated compared with the control leg (0.0344 ± 0.0019 vs. 0.0297 ± 0.0016 MPE, respectively; P protein-derived amino acids in the NMES compared with CON leg. In conclusion, application of NMES prior to presleep protein feeding stimulates the use of dietary protein-derived amino acids for overnight muscle protein synthesis in older men. Neuromuscular electrical stimulation (NMES) as well as presleep dietary protein ingestion represent effective strategies to stimulate muscle protein synthesis rates. Here we demonstrate that in older men after a day of bed rest, the application of NMES prior to presleep protein feeding stimulates the use of

  16. Las organizaciones ¿favorecen o dificultan una práctica enfermera basada en la evidencia?

    Directory of Open Access Journals (Sweden)

    Joan Ernest de Pedro Gómez

    Full Text Available El Artículo pretende desde una mirada crítica reflexionar sobre la posición e influencia de las organizaciones, respecto al desarrollo en la práctica clínica de los cuidados enfermeros. Es mucha la evidencia y son muchas las razones para demandar de las organizaciones, un posicionamiento que favorezca el cambio en los Modelos de Práctica Enfermera (MPE. Dada la influencia que tienen los cuidados en los resultados del proceso clínico (morbi-moratlidad y entendiendo éste como el objetivo de las organizaciones sanitarias, parece lógico intentar que las estructuras organizativas abandonen procesos asistenciales totalmente desfasados, para ofrecer los mejores servicios de salud. Para ello es necesario aplicar los resultados de investigación, tanto en la dotación de enfermeras como en la definición de servicios y cuidados enfermeros. Son las organizaciones las que deben establecer las condiciones para que las Enfermeras actúen en un plano de colaboración con otros profesionales y no de sumisión, posición desde la cual no pueden desarrollar su potencial profesional, el cual resulta necesario para un cambio de la prestación de servicios, adaptando éste a las demandas existentes. Sin la adecuada gestión, encaminada a la utilización del conocimiento enfermero como valor organizacional, será imposible adaptar las necesidades de cuidados a las demandas de servicios. Las organizaciones deben optar por un servicio en el que el MPE permita la inclusión de aquellos resultados de investigación con notables efectos en la calidad de sus procesos, las organizaciones deben asumir la responsabilidad de actuar bajo un modelo, que a todas luces no puede ser otro que el de aplicar en la práctica clínica las evidencias producidas por la investigación.

  17. Experimental Approach for the Uncertainty Assessment of 3D Complex Geometry Dimensional Measurements Using Computed Tomography at the mm and Sub-mm Scales.

    Science.gov (United States)

    Jiménez, Roberto; Torralba, Marta; Yagüe-Fabra, José A; Ontiveros, Sinué; Tosello, Guido

    2017-05-16

    The dimensional verification of miniaturized components with 3D complex geometries is particularly challenging. Computed Tomography (CT) can represent a suitable alternative solution to micro metrology tools based on optical and tactile techniques. However, the establishment of CT systems' traceability when measuring 3D complex geometries is still an open issue. In this work, an alternative method for the measurement uncertainty assessment of 3D complex geometries by using CT is presented. The method is based on the micro-CT system Maximum Permissible Error (MPE) estimation, determined experimentally by using several calibrated reference artefacts. The main advantage of the presented method is that a previous calibration of the component by a more accurate Coordinate Measuring System (CMS) is not needed. In fact, such CMS would still hold all the typical limitations of optical and tactile techniques, particularly when measuring miniaturized components with complex 3D geometries and their inability to measure inner parts. To validate the presented method, the most accepted standard currently available for CT sensors, the Verein Deutscher Ingenieure/Verband Deutscher Elektrotechniker (VDI/VDE) guideline 2630-2.1 is applied. Considering the high number of influence factors in CT and their impact on the measuring result, two different techniques for surface extraction are also considered to obtain a realistic determination of the influence of data processing on uncertainty. The uncertainty assessment of a workpiece used for micro mechanical material testing is firstly used to confirm the method, due to its feasible calibration by an optical CMS. Secondly, the measurement of a miniaturized dental file with 3D complex geometry is carried out. The estimated uncertainties are eventually compared with the component's calibration and the micro manufacturing tolerances to demonstrate the suitability of the presented CT calibration procedure. The 2U/T ratios resulting from the

  18. Decrease of dynamic loads in mobile energy means

    Science.gov (United States)

    Polivaev, O. I.; Gorban, L. K.; Vorohobin, A. V.; Vedrinsky, O. S.

    2018-03-01

    The increase in the productivity of machine and tractor units is possible due to the increase in operating speeds, this leads to the emergence of increased dynamic loads in the system “engine-transmission-propulsion unit-soil”, which worsens the performance of machine-tractor aggregates. To reduce fluctuations in the “engine-transmission” system, special vibration dampers are used, which installed in close proximity to the engine and protect well the transmission from uneven engine operation; however, such dampers practically do not eliminate the oscillations of external loads. Reducing dynamic loads on the transmission and the mobile power engine (MPE) is an important issue directly related to improving the performance, reliability and durability of the tractor, as well as reducing the slippage of the drive wheels. In order to reduce effectively dynamic loads on the transmission and on the MPE, it is necessary to introduce resilient damping elements closer to the sources of oscillations, namely, to the driving wheels. At the same time, the elastic-damping element should provide accumulation of vibration energy caused by external influences and have a large energy capacity. The installation of an elastic-damping element in the final link of the tractor transmission ensures a reduction in the magnitude of external influences, thereby protecting the engine and transmission from large dynamic loads, and allows one to reduce the slippage of the propellers, which has a positive effect on the traction and energy characteristics of the tractor. Traction tests of the LTP-55 tractor on a concrete road showed that the use of an elasto-damping drive makes it possible to increase the maximum tractive power from 33.5 to 35.3 kW and to reduce the slipping of propellers by 12-30%, the specific fuel consumption by 6-10%. When driving on stubble, the use of an elastic-damping drive increases the maximum tractive power from 25 to 26 kW, reduces the skidding of propellers by

  19. Sistema de controle de velocidade sincronizada entre dois veículos agrícolas Synchronized speed control system between two agricultural vehicles

    Directory of Open Access Journals (Sweden)

    Rodrigo Fernando Galzerano Baldo

    2012-02-01

    master tractor speed and registering the slave tractor response. In the first test the slave tractor followed the speed variation simulated with a mean square error (MSE non-significant and a maximum mean percentage error (MPE of 1.3%. In the second test the slave tractor followed the master tractor speed variation with a displacement (MPE ranging in magnitude from 0.2% to 2.9%.

  20. UNA EXPERIENCIA EN LA IMPLEMENTACIÓN DEL SISTEMA DE GESTIÓN DE LA CALIDAD DE UNA EMPRESA DE SERVICIO / AN EXPERIENCE IN THE IMPLEMENTATION OF THE QUALITY MANAGEMENT SYSTEM IN A SERVICE ENTERPRISE

    Directory of Open Access Journals (Sweden)

    Ester Michelena-Fernández

    2011-03-01

    Full Text Available

    El presente artículo muestra un procedimiento para el rediseño e implementación parcial del Sistema de Gestión de la Calidad (SGC de una empresa de servicios. Para llevar a cabo este estudio, se propuso que el objetivo general estuviese encaminado a realizar un rediseño en el SGC con un enfoque a proceso, estableciendo las interrelaciones de las actividades y tareas, así como los procedimientos obligatorios, según establece la Norma ISO 9001-2008. Con el fin de lograr la realización y cumplimiento del objetivo propuesto, se pusieron en práctica métodos y técnicas de diseño y mejoramiento de procesos, como por ejemplo el análisis, síntesis y deducción; además de implementar las metodologías PHVA y MPE de Harrigton (1997 [1]. En la etapa inicial del estudio realizado, se detectó que en el sistema de gestión que utilizaba esta empresa se presentaban un gran número de no conformidades y no cumplía con los requerimientos de la Norma ISO 9001-2008, lo que estaba influyendo negativamente en la calidad de los servicios ofertados y la satisfacción de los requerimientos de los clientes, lo que demostró la necesidad del rediseño del SGC.

    Abstract

    This article presents a procedure for the redesign and partial implementation of the Quality Management System (QMS in a service enterprise. To carry out this study, it was suggested that the main purpose aimed at a redesign of the QMS taking into account a process approach, establishing the interrelation of activities and tasks, as well as mandatory procedures, as established by the ISO 9001-2008 Standard. In order to achieve the completion and implementation of the established purpose, methods and techniques of design and process improvement, such as analysis, synthesis, and deduction, were put into practice, in addition to the implementation of the PDCA methodology and MPE from Harrington (1997 [1]. In the initial stage of study of the management

  1. Erzwingt die Quantenmechanik eine drastische Änderung unseres Weltbilds? Gedanken und Experimente nach Einstein, Podolsky und Rosen

    Science.gov (United States)

    Frodl, Peter

    Von den Anfängen der Quantenmechanik bis heute gibt es Versuche, sie als statistische Theorie über Ensembles individueller klassischer Systeme zu interpretieren. Die Bedingungen, unter denen Theorien verborgener Parameter zu deterministischen Beschreibungen dieser individuellen Systeme als klassisch angesehen werden können, wurden von Einstein, Podolsky und Rosen 1935 formuliert: 1. Physikalische Systeme sind im Prinzip separierbar. 2. Zu jeder physikalischen Größe, deren Wert man ohne Störung des betrachteten Systems mit Sicherheit voraussagen kann, existiert ein ihr entsprechendes Element der physikalischen Realität.Zusammen sind sie, wie Bell 1964 gezeigt hat, prinzipiell unverträglich mit der Quantenmechanik und unhaltbar angesichts neuerer Experimente. Diese erweisen einmal mehr die Quantenmechanik als richtige Theorie. Um ihre Ergebnisse zu verstehen, müssen wir entweder die in der klassischen Physik als selbstverständlich angesehene Annahme der Separierbarkeit physikalischer Systeme aufgeben oder unseren Begriff der physikalischen Realität revidieren. Eine Untersuchung des Begriffs der Separabilität und einige Überlegungen zum Problem der Messung von Observablen zeigen, daß eine Änderung des Begriffs der physikalischen Realität unumgänglich ist. Der revidierte Realitätsbegriff sollte mit klassischer Physik und Quantenmechanik verträglich sein, um ein einheitliches Weltbild zu ermöglichen.Translated AbstractDo Quantum Mechanics Force us to Drastically Change our View of the World? Thoughts and Experiments after Einstein, Podolsky and RosenSince the advent of quantum mechanics there have been attempts of its interpretation in terms of statistical theory concerning individual classical systems. The very conditions necessary to consider hidden variable theories describing these individual systems as classical had been pointed out by Einstein, Podolsky and Rosen in 1935: 1. Physical systems are in principle separable. 2. If it is possible to

  2. Max Planck in the Social Context

    Energy Technology Data Exchange (ETDEWEB)

    Broda, E.

    1983-07-01

    Planck was the founder of quantum theory, and therefore of modern physics. Moreover, because of the strength of his character and of his towering position in scientific life he had strong public influence. In respect to atomistics Planck went over from the negative position of Mach to the positive position of Boltzmann when he established his radiation law and introduced the quantum of action. Einstein was a supporter of atomistics all his life. From the beginning, Planck furthered the Theory of Relativity and Einstein. In the Weimar Republic he supported Einstein against the socalled 'German Physics'. Planck had the courage to praise Einstein in public even after Hitler came to power. Always interested in philosophy, Planck was initially under the influence of Mach's positivism, but later he turned, like Einstein, to realism. Boltzmann had always been arealist and materialist. Planck produced important ideas also on the problem of Free Will. In politics, Planck was a conventional, conservative, PrussianGerman patriot before the First War. However, under Hitler he became reserved towards the State. As well as he could, but with little success, Planck tried to prevent the worst. Planck was always religious, and he ascribed a strong role to religion also in public life. But he did not accept a personal, and therefore not a Christian, God. An attempt is made to interpret Planck's contradictory position in this respect. Planck's life was full of professional success, but it was tragically darkened by personal blows of fate. A relationship with the path of Germany and of her conservative intellectual leadership is sought. (author) [German] Planck war der Begründer der Quantentheorie und daher der modernen Physik. Außerdem hatte er sowohl durch die Kraft seines Charakters als auch durch seine überragenden Funktionen im wissenschaftlichen Leben starken öffentlichen Einfluß. In Bezug auf die Stellung zur Atomistik ging Planck, als er sein Strahlungsgesetz begr

  3. 24 April 2018: Ordinary General Assembly of the Staff Association!

    CERN Multimedia

    Staff Association

    2018-01-01

    In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Tuesday, 24 April 2018 from 14.00 to 16.00, Main Auditorium, Meyrin (500-1-001). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its management, and an opportunity to express your opinion, particularly by taking part in votes. Other items are listed on the agenda, as proposed by the Staff Council. Who can vote? Ordinary members (MPE) of the SA can take part in all votes. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give their opinion, and how? The Ordinary General Assembly is also the opportunity for members of the SA to express themselves through the addition of discus...

  4. 24 April 2018: Ordinary General Assembly of the Staff Association!

    CERN Multimedia

    Staff Association

    2018-01-01

    In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Thursday, 24 April 2018 from 14.00 to 16.00, Main Auditorium, Meyrin (500-1-001). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its management, and an opportunity to express your opinion, particularly by taking part in votes. Other items are listed on the agenda, as proposed by the Staff Council. Who can vote? Ordinary members (MPE) of the SA can take part in all votes. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give their opinion, and how? The Ordinary General Assembly is also the opportunity for members of the SA to express themselves through the addition of disc...

  5. 29th June 2017 – Ordinary General Assembly of the Staff Association!

    CERN Document Server

    Staff Association

    2017-01-01

    In the first semester of each year, the Staff Association (SA) invites its members to attend and participate in the Ordinary General Assembly (OGA). This year the OGA will be held on Thursday, 29 June 2017 from 15.30 to 17.30, Main Auditorium, Meyrin (500-1-001). During the Ordinary General Assembly, the activity and financial reports of the SA are presented and submitted for approval to the members. This is the occasion to get a global view on the activities of the SA, its management, and an opportunity to express your opinion, particularly by taking part in votes. Other items are listed on the agenda, as proposed by the Staff Council. Who can vote? Ordinary members (MPE) of the SA can take part in all votes. Associated members (MPA) of the SA and/or affiliated pensioners have a right to vote on those topics that are of direct interest to them. Who can give their opinion, and how? The Ordinary General Assembly is also the opportunity for members of the SA to express themselves through the addition of disc...

  6. Empirical Models For The Correlation With Sunshine Duration of Metrological Data For Tikrit-TuzKhurmato and Kirkuk-IRAQ

    Directory of Open Access Journals (Sweden)

    Fayadh M. Abed Al-Dulaimy

    2012-03-01

    Full Text Available Measurements of metrological data of maximum, minimum ambient temperature, humidity and sunshine duration for a period of 23 years during the period of 1977-2000, at Tikrit (34. 35°N, 43.37°E, TuzKurmato (34.88°N, 44.64°E, and Kirkuk (35.30°N, 44. 21°E, were used to established an Angstrom type corrélation équations for direct global solar radiation. The diffuse radiation was estimated by using klien and Page Models. This calculation appears to be sufficient to discriminate each station from the others due to it’s local characteristic of the sites. The overall results shown for TuzKurmato, the received radiation on the plane surface is higher than Tikrit and Kirkuk while the diffuse radiation reversely behaved as for Tiktit is the highest. The developed model can be used for estimating global solar radiation on horizontal surfaces. The monthly average total solar radiation was estimated. The value of correlation coefficient (r and value of Root Mean Square Error (RMSE, Mean Bias Error (MBE and Mean Percentage Error (MPE were determined for each equation

  7. Point spread function and centroiding accuracy measurements with the JET-X mirror and MOS CCD detector of the Swift gamma ray burst explorer's X-ray telescope

    CERN Document Server

    Ambrosi, R M; Hutchinson, I B; Willingale, R; Wells, A; Short, A D T; Campana, S; Citterio, O; Tagliaferri, G; Burkert, W; Bräuninger, H

    2002-01-01

    The optical components of the Swift X-ray telescope (XRT) are already developed items. They are the flight spare X-ray mirror from the JET-X/Spectrum-X program and an MOS CCD (CCD22) of the type currently operating in orbit as part of the EPIC focal plane camera on XMM-Newton (SPIE 4140 (2000) 64). The JET-X mirrors were first calibrated at the Max Planck Institute for Extraterrestrial Physics' (MPE) Panter facility, Garching, Germany in 1996 (SPIE 2805 (1996) 56; SPIE 3114 (1997) 392). Half-energy widths of 16 arcsec at 1.5 keV were confirmed for the two flight mirrors and the flight spare. The calibration of the flight spare was repeated at Panter in July 2000 in order to establish whether any changes had occurred during the 4 yr that the mirror had been in storage at the OAB, Milan, Italy. The results reported in this paper confirm that the resolution of the JET-X mirrors has remained stable over this storage period. In an extension of this test program, the flight spare EPIC camera was installed at the fo...

  8. Laser Safety and Hazard Analysis for the Trailer (B70) Based AURA Laser System

    International Nuclear Information System (INIS)

    AUGUSTONI, ARNOLD L.

    2003-01-01

    A laser safety and hazard analysis was performed for the AURA laser system based on the 2000 version of the American National Standards Institute's (ANSI) Standard Z136.1, for ''Safe Use of Lasers'' and the 2000 version of the ANSI Standard Z136.6, for ''Safe Use of Lasers Outdoors''. The trailer based AURA laser system is a mobile platform, which is used to perform laser interaction experiments and tests at various national test sites. The trailer (B70) based AURA laser system is generally operated on the United State Air Force Starfire Optical Range (SOR) at Kirtland Air Force Base (KAFB), New Mexico. The laser is used to perform laser interaction testing inside the laser trailer as well as outside the trailer at target sites located at various distances from the exit telescope. In order to protect personnel, who work inside the Nominal Hazard Zone (NHZ), from hazardous laser emission exposures it was necessary to determine the Maximum Permissible Exposure (MPE) for each laser wavelength (wavelength bands) and calculate the appropriate minimum Optical Density (OD min ) of the laser safety eyewear used by authorized personnel and the Nominal Ocular Hazard Distance (NOHD) to protect unauthorized personnel who may have violated the boundaries of the control area and enter into the laser's NHZ

  9. Spatial chaos of Wang tiles with two symbols

    Science.gov (United States)

    Chen, Jin-Yu; Chen, Yu-Jie; Hu, Wen-Guei; Lin, Song-Sun

    2016-02-01

    This investigation completely classifies the spatial chaos problem in plane edge coloring (Wang tiles) with two symbols. For a set of Wang tiles B , spatial chaos occurs when the spatial entropy h ( B ) is positive. B is called a minimal cycle generator if P ( B ) ≠ 0̸ and P ( B ' ) = 0̸ whenever B ' ⫋ B , where P ( B ) is the set of all periodic patterns on ℤ2 generated by B . Given a set of Wang tiles B , write B = C 1 ∪ C 2 ∪ ⋯ ∪ C k ∪ N , where Cj, 1 ≤ j ≤ k, are minimal cycle generators and B contains no minimal cycle generator except those contained in C1∪C2∪⋯∪Ck. Then, the positivity of spatial entropy h ( B ) is completely determined by C1∪C2∪⋯∪Ck. Furthermore, there are 39 equivalence classes of marginal positive-entropy sets of Wang tiles and 18 equivalence classes of saturated zero-entropy sets of Wang tiles. For a set of Wang tiles B , h ( B ) is positive if and only if B contains a MPE set, and h ( B ) is zero if and only if B is a subset of a SZE set.

  10. In Vitro Antioxidant Activities of Phenols and Oleanolic Acid from Mango Peel and Their Cytotoxic Effect on A549 Cell Line

    Directory of Open Access Journals (Sweden)

    Xuelian Bai

    2018-06-01

    Full Text Available Mango peel, the main by-product of juice processing, possesses appreciable quantities of bioactive phenolic compounds and is worthy of further utilization. The present work reports for the first time the HPLC analysis and in vitro antioxidant evaluation of mango peel phenols (MPPs and their cytotoxic effect on the A549 lung cancer cell line. These results indicated that mango peel has the total phenolic content of 723.2 ± 0.93 mg·kg−1 dry mango peel (DMP, which consisted mainly of vanillic aldehyde, caffeic acid, chlorogenic acid, gallic acid, procyanidin B2 and oleanolic acid. Antioxidant assays showed that MPPs had strong antioxidant activities, with 92 ± 4.2% of DPPH radical scavenging rate, 79 ± 2.5% of ABTS radical inhibition rate and 4.7 ± 0.5 μM Trolox equivalents per kg−1 DMP of ferric reducing power. Gallic acid possess a stronger antioxidant capacity than other phenols. In vitro cytotoxic tests suggested that mango peel extract (MPE had an IC50 value of 15 mg·mL−1 and MPPs had a stronger inhibitory effect on the A549 cell line. Oleanolic acid exhibited the strongest cytotoxicity, with an IC50 value of 4.7 μM, which was similar with that of the positive control 5-fluorouracil.

  11. EVE et École

    CERN Multimedia

    Staff Association

    2017-01-01

    Il reste des places disponibles ! La structure Espace de vie enfantine (EVE) et École de l’Association du personnel du CERN vous informe qu’il reste quelques places pour la rentrée scolaire 2017-2018 : à la crèche (2-3 ans) (accueil sur 2, 3 ou 5 jours) ; au jardin d’enfants (2-4 ans) (accueil à la matinée) ; en classe de 1ère primaire (1P) (4-5 ans). N’hésitez pas à rapidement nous contacter si vous êtes intéressés ; nous sommes à votre disposition pour répondre à toutes vos questions : Staff.Kindergarten@cern.ch. L’EVE et École de l’Association du personnel du CERN est ouverte non seulement aux enfants des personnels du CERN (MPE, MPA) mais également aux enfants des personnes ne travaillant pas sur le domaine du CERN. ...

  12. EVE and School: Important announcement

    CERN Multimedia

    Staff Association

    2017-01-01

    Children’s Day-Care Centre (EVE) and School of the CERN Staff Association would like to inform you that there are still a few places available within the structure for the school year 2017–2018, in the: Nursery for 2, 3 or 5 days a week (2- to 3-year-olds); Kindergarten for mornings (2- to 4-year-olds); Primary 1 (1p) class in the School (4- to 5-year-olds). Please get in touch with us quickly if you are interested in any of the available places. We will gladly provide further information and answer any questions you may have: Staff.Kindergarten@cern.ch or (+41) 022 767 36 04 (mornings). EVE and School of the CERN Staff Association welcomes children of CERN Members of Personnel (MPE, MPA), as well as children whose parents do not work on CERN site. We would like to remind you that registrations are also open for the Summer Camp. The camp will run through the four weeks of July from 8.30 am to 5.30 pm with a weekly registration for 450 CHF, lunch included. For more information and regist...

  13. STRATEGI DIVERSIFIKASI PRODUK KAYU OLAHAN Acacia mangium (studi kasus : PT. Musi Hutan Persada

    Directory of Open Access Journals (Sweden)

    Hamzah Hamzah

    2011-08-01

    Full Text Available Normal 0 false false false MicrosoftInternetExplorer4 The objective of this study is to suggest  the best wood  products of Acacia mangium  that have  high value-added as an alternative business and to formulate the fitting  strategy. This study  is descriptive case study applying  purposive sampling method which involved wood product Experts and Senior PT. Musi Hutan Persada Management.  Data have been analyzed through Exponential Compare Method (MPE to select the best product alternative based on eleven set criteria, using AHP method, Hayami value-added Analysis, and Cost Analysis.  The study shows that there are five superior Acacia mangium based products, namely 1 Sawnwood and woodworking (KGKO, 2 Furniture, 3 Medium Density Fibreboard (MDF, 4 Tannin-glue of Acacia mangium  bark and 5 Wood Charcoal.  And  Sawnwood and Woodworking (KGKO, Furniture, and   Tannin-glue  have the best chance.  Best business strategy to be adhered by MHP, “related-diversification”, then is  to continue utilizing  Acacia mangium wood  as renewable resources,  integrated and sustainable business.

  14. Silicon drift detectors coupled to CsI(Tl) scintillators for spaceborne gamma-ray detectors

    International Nuclear Information System (INIS)

    Marisaldi, M.; Fiorini, C.; Labanti, C.; Longoni, A.; Perotti, F.; Rossi, E.; Soltau, H.

    2006-01-01

    Silicon Drift Detectors (SDDs), thanks to their peculiar low noise characteristics, have proven to be excellent photodetectors for CsI(Tl) scintillation light detection. Two basic detector configurations have been developed: either a single SDD or a monolithic array of SDDs coupled to a single CsI(Tl) crystal. A 16 independent detectors prototype is under construction, designed to work in conjunction with the MEGA Compton telescope prototype under development at MPE, Garching, Germany. A single SDD coupled to a CsI(Tl) crystal has also been tested as a monolithic detector with an extended energy range between 1.5 keV and 1 MeV. The SDD is used as a direct X-ray detector for low energy photons interacting in silicon and as a scintillation light photodetector for photons interacting in the crystal. The type of interaction is identified by means of pulse shape discrimination technique. Detectors based on an array of SDDs coupled to a single CsI(Tl) crystal have also been built. The readout of these detectors is based on the Anger camera technique, and submillimeter spatial resolution can be achieved. The two detectors' approaches and their applications will be described

  15. BREXIT

    DEFF Research Database (Denmark)

    Krejsler, John Benedicto

    2016-01-01

    man beholde dette, må man acceptere ’den fri bevægelighed’ inden for EU for arbejdskraft (herunder studerende), varer, tjenesteydelser og kapital. Det bliver sikkert svært at sluge for de brexiteers, der først og fremmest tænkte på mindsket indvandring fra lande som Polen, de baltiske lande og senest...... filosof og sociolog Jürgen Habermas – en af mine helte i denne sammenhæng − har gennem årtier kæmpet for, at EU i stigende grad kunne blive den politiske institutionaliserede kraft, som havde nok tyngde til at matche markedets p.t. alt for ensidige dominans. Dette er kun delvist lykkedes. Mange vil...... formentlig sige, at det er mislykkedes. Der er i alle fald ingen tvivl om, at der stadig er meget at kæmpe for for at skabe mere balance mellem et politisk system med demokratisk og folkelig legitimitet og så det overvejende nyliberalt inspirerede markedsperspektiv, som p.t. dominerer. Men at hævde, at det...

  16. Line spread functions of blazed off-plane gratings operated in the Littrow mounting

    Science.gov (United States)

    DeRoo, Casey T.; McEntaffer, Randall L.; Miles, Drew M.; Peterson, Thomas J.; Marlowe, Hannah; Tutt, James H.; Donovan, Benjamin D.; Menz, Benedikt; Burwitz, Vadim; Hartner, Gisela; Allured, Ryan; Smith, Randall K.; Günther, Ramses; Yanson, Alex; Vacanti, Giuseppe; Ackermann, Marcelo

    2016-04-01

    Future soft x-ray (10 to 50 Å) spectroscopy missions require higher effective areas and resolutions to perform critical science that cannot be done by instruments on current missions. An x-ray grating spectrometer employing off-plane reflection gratings would be capable of meeting these performance criteria. Off-plane gratings with blazed groove facets operating in the Littrow mounting can be used to achieve excellent throughput into orders achieving high resolutions. We have fabricated two off-plane gratings with blazed groove profiles via a technique that uses commonly available microfabrication processes, is easily scaled for mass production, and yields gratings customized for a given mission architecture. Both fabricated gratings were tested in the Littrow mounting at the Max Planck Institute for Extraterrestrial Physics (MPE) PANTER x-ray test facility to assess their performance. The line spread functions of diffracted orders were measured, and a maximum resolution of 800±20 is reported. In addition, we also observe evidence of a blaze effect from measurements of relative efficiencies of the diffracted orders.

  17. Optical and x-ray alignment approaches for off-plane reflection gratings

    Science.gov (United States)

    Allured, Ryan; Donovan, Benjamin D.; DeRoo, Casey T.; Marlowe, Hannah R.; McEntaffer, Randall L.; Tutt, James H.; Cheimets, Peter N.; Hertz, Edward; Smith, Randall K.; Burwitz, Vadim; Hartner, Gisela; Menz, Benedikt

    2015-09-01

    Off-plane reflection gratings offer the potential for high-resolution, high-throughput X-ray spectroscopy on future missions. Typically, the gratings are placed in the path of a converging beam from an X-ray telescope. In the off-plane reflection grating case, these gratings must be co-aligned such that their diffracted spectra overlap at the focal plane. Misalignments degrade spectral resolution and effective area. In-situ X-ray alignment of a pair of off-plane reflection gratings in the path of a silicon pore optics module has been performed at the MPE PANTER beamline in Germany. However, in-situ X-ray alignment may not be feasible when assembling all of the gratings required for a satellite mission. In that event, optical methods must be developed to achieve spectral alignment. We have developed an alignment approach utilizing a Shack-Hartmann wavefront sensor and diffraction of an ultraviolet laser. We are fabricating the necessary hardware, and will be taking a prototype grating module to an X-ray beamline for performance testing following assembly and alignment.

  18. Radiation detectors for use in major public events: classification, requirements, main features, tests and lessons learned

    International Nuclear Information System (INIS)

    Souza, Elder Magalhães de

    2017-01-01

    Since September 11, 2001, we have entered a new terrorism era. The possibility of the use of lost/stolen radioactive materials increases the probability of a radiological threat. The real goal intended with the use of a Radiological Dispersal Device (RRD or dirty bomb) or a Radiation Exposure Device (RDE) could be psychological in nature. Panic in the venues and surrounding area would cause more deaths than the RDD itself, therefore these attempts could cause chaos, injury, fear and terror, the main target of terrorists. The response of the national authorities with the support and aid of the IAEA served as an increase of the capability of detection and identification of nuclear and radiological materials. But this response could not be limited only to the MPE, because if the country has radioactive or nuclear facilities they also should be considered in terms of theft, sabotage, illegal transfer, unauthorized access, and any other malicious acts. In 2007, Rio de Janeiro, received the first Brazilian Major Public Event in this new era. This was the first Brazilian operation which largely utilized detectors (personal radiations detectors -PRD- radiological identification detectors, -RID or RIID- and spectral radiations scanners, -backpacks-, HPGe detectors, car-borne and air-borne systems) to protect the venues, the athletes, the population and the environment. (author)

  19. Factors Associated with the Choice of Peritoneal Dialysis in Patients with End-Stage Renal Disease

    Directory of Open Access Journals (Sweden)

    Pei-Chun Chiang

    2016-01-01

    Full Text Available Background. The purpose of this study was to analyze the factors associated with receiving peritoneal dialysis (PD in patients with incident end-stage renal disease (ESRD in a hospital in Southern Taiwan. Methods. The study included all consecutive patients with incident ESRD who participated in a multidisciplinary predialysis education (MPE program and started their first dialysis therapy between January 1, 2008, and June 30, 2013, in the study hospital. We provided small group teaching sessions to advanced CKD patients and their family to enhance understanding of various dialysis modalities. Multivariate logistic regression models were used to analyze the association of patient characteristics with the chosen dialysis modality. Results. Of the 656 patients, 524 (80% chose hemodialysis and 132 chose PD. Our data showed that young age, high education level, and high scores of activities of daily living (ADLs were positively associated with PD treatment. Patients who received small group teaching sessions had higher percentages of PD treatment (30.5% versus 19.5%; P=0.108 and preparedness for dialysis (61.1% versus 46.6%; P=0.090. Conclusion. Young age, high education level, and high ADL score were positively associated with choosing PD. Early creation of vascular access may be a barrier for PD.

  20. Annex A1: cornerstone of the five-yearly review

    CERN Multimedia

    Staff Association

    2016-01-01

    As a reminder; the purpose of the five-yearly review is to review the financial and social conditions of all CERN personnel whether employed (MPE) or associated (MPA)! In December 2015, the CERN Council approved the package proposed by the Management. Early this year, and as final act of the 2015 five-yearly review, the CERN Council may decide, if necessary and appropriate, to review the procedures defined in Annex A1 and applicable to future five-yearly reviews. At the meeting of TREF (TRipartite Employment Forum)  in early March 2016 discussions will take place between all stakeholders (representatives of Member States, Management and the Staff Association) and Council will take a decision in June 2016, on the basis of the Management's recommendations. What does Annex A1 say and where can I find it? Annex A1 (Article S V 1.02) is a part of the Staff Rules and Regulations. This annex defines: The five-yearly review of the financial and social conditions of the staff, fellows and MPA; The a...