WorldWideScience

Sample records for extract exhibited significant

  1. Extract from Ceratonia siliqua Exhibits Depigmentation Properties.

    Science.gov (United States)

    Lall, Namrita; Kishore, Navneet; Momtaz, Saeideh; Hussein, Ahmed; Naidoo, Sanushka; Nqephe, Mabatho; Crampton, Bridget

    2015-11-01

    Skin hyper-pigmentation is a condition initiated by the overproduction of melanin existing in the melanocytes. Melanin pigment is responsible for the colour of skin in humans. It is formed through a series of oxidative reactions involving the amino acid tyrosine in the presence of the key enzyme tyrosinase. In continuation with our efforts to identify tyrosinase inhibitors from plants sources, the methanol extract from leaf, bark and fruit of Ceratonia siliqua were screened for tyrosinase inhibition and diphenolase activity. The bark extract exhibited significant inhibition on mushroom tyrosinase using L-tyrosine as a substrate and showed diphenolase activity. The extract further significantly lowered tyrosinase mRNA levels in B16-F10 mouse melanocytes. Bioassay-guided fractionation led to the isolation of six compounds. Compounds (-)-epicatechin-3-O-gallate, 1,2,3,6-tetra-O-galloyl-ß-D-glucose and gallocatechin-3-O-gallate showed tyrosinase inhibitions with the IC50 values of 27.52, 83.30 and 28.30 µg/mL, respectively. These compounds also exhibited L-DOPA activities with IC50 values of >200, 150 and 200 µg/mL, respectively. A clinical study was conducted using 20 volunteers in a patch testing trial for irritancy potential and skin depigmentation. The clinical results showed the sample to be non-irritant with irritancy potential of -34.21 and depigmentation trial showed an improvement in the even skin tone of UV induced pigmentation at 3% after 28 days of application.

  2. 78 FR 7849 - Culturally Significant Objects Imported for Exhibition

    Science.gov (United States)

    2013-02-04

    ... Opulence: British Art at the Dawn of the Twentieth Century,'' imported from abroad for temporary exhibition... Culturally Significant Objects Imported for Exhibition Determinations: ``Edwardian Opulence: British Art at the Dawn of the Twentieth Century'' SUMMARY: Notice is hereby given of the following...

  3. Piper betle extracts exhibit antitumor activity by augmenting antioxidant potential.

    Science.gov (United States)

    Alam, Badrul; Majumder, Rajib; Akter, Shahina; Lee, Sang-Han

    2015-02-01

    The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells into mice, extracts were administered at 25, 50 and 100 mg/kg body weight for nine consecutive days. The antitumor effects of the extracts were then assessed according to tumor volume, packed cell count, viable and non-viable tumor cell count, median survival time and increase in life span of EAC-bearing mice. Next, hematological profiles and serum biochemical parameters were calculated, and antioxidant properties were assessed by estimating lipid peroxidation, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) levels. MPBL and the ethylacetate fraction (EPBL) at a dose of 100 mg/kg induced a significant decrease in tumor volume, packed cell volume and viable cell count and increased the life span of the EAC-bearing mice (PPiper betle extracts exhibit significant antitumor activity, which may be attributed to the augmentation of endogenous antioxidant potential.

  4. 76 FR 68808 - Culturally Significant Objects Imported for Exhibition

    Science.gov (United States)

    2011-11-07

    ... Exhibition Determinations: ``Transition to Christianity: Art of Late Antiquity, 3rd-7th Century AD'' SUMMARY... objects to be included in the exhibition ``Transition to Christianity: Art of Late Antiquity, 3rd-7th Century AD,'' imported from abroad for temporary exhibition within the United States, are of...

  5. 76 FR 44976 - Culturally Significant Objects Imported for Exhibition Determinations: “Heroic Africans...

    Science.gov (United States)

    2011-07-27

    ... Exhibition Determinations: ``Heroic Africans: Legendary Leaders, Iconic Sculptures'' SUMMARY: Notice is... objects to be included in the exhibition ``Heroic Africans: Legendary Leaders, Iconic Sculptures,'' imported from abroad for temporary exhibition within the United States, are of cultural significance....

  6. 75 FR 7649 - Culturally Significant Objects Imported for Exhibition Determinations: “Otto Dix”

    Science.gov (United States)

    2010-02-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Otto Dix'' SUMMARY: Notice is hereby... included in the exhibition ``Otto Dix,'' imported from abroad for temporary exhibition within the...

  7. Bauhinia variegata leaf extracts exhibit considerable antibacterial, antioxidant, and anticancer activities.

    Science.gov (United States)

    Mishra, Amita; Sharma, Amit Kumar; Kumar, Shashank; Saxena, Ajit K; Pandey, Abhay K

    2013-01-01

    The present study reports the phytochemical profiling, antimicrobial, antioxidant, and anticancer activities of Bauhinia variegata leaf extracts. The reducing sugar, anthraquinone, and saponins were observed in polar extracts, while terpenoids and alkaloids were present in nonpolar and ethanol extracts. Total flavonoid contents in various extracts were found in the range of 11-222.67 mg QE/g. In disc diffusion assays, petroleum ether and chloroform fractions exhibited considerable inhibition against Klebsiella pneumoniae. Several other extracts also showed antibacterial activity against pathogenic strains of E. coli, Proteus spp. and Pseudomonas spp. Minimum bactericidal concentration (MBC) values of potential extracts were found between 3.5 and 28.40 mg/mL. The lowest MBC (3.5 mg/mL) was recorded for ethanol extract against Pseudomonas spp. The antioxidant activity of the extracts was compared with standard antioxidants. Dose dependent response was observed in reducing power of extracts. Polar extracts demonstrated appreciable metal ion chelating activity at lower concentrations (10-40 μg/mL). Many extracts showed significant antioxidant response in beta carotene bleaching assay. AQ fraction of B. variegata showed pronounced cytotoxic effect against DU-145, HOP-62, IGR-OV-1, MCF-7, and THP-1 human cancer cell lines with 90-99% cell growth inhibitory activity. Ethyl acetate fraction also produced considerable cytotoxicity against MCF-7 and THP-1 cell lines. The study demonstrates notable antibacterial, antioxidant, and anticancer activities in B. variegata leaf extracts.

  8. Bauhinia variegata Leaf Extracts Exhibit Considerable Antibacterial, Antioxidant, and Anticancer Activities

    Directory of Open Access Journals (Sweden)

    Amita Mishra

    2013-01-01

    Full Text Available The present study reports the phytochemical profiling, antimicrobial, antioxidant, and anticancer activities of Bauhinia variegata leaf extracts. The reducing sugar, anthraquinone, and saponins were observed in polar extracts, while terpenoids and alkaloids were present in nonpolar and ethanol extracts. Total flavonoid contents in various extracts were found in the range of 11–222.67 mg QE/g. In disc diffusion assays, petroleum ether and chloroform fractions exhibited considerable inhibition against Klebsiella pneumoniae. Several other extracts also showed antibacterial activity against pathogenic strains of E. coli, Proteus spp. and Pseudomonas spp. Minimum bactericidal concentration (MBC values of potential extracts were found between 3.5 and 28.40 mg/mL. The lowest MBC (3.5 mg/mL was recorded for ethanol extract against Pseudomonas spp. The antioxidant activity of the extracts was compared with standard antioxidants. Dose dependent response was observed in reducing power of extracts. Polar extracts demonstrated appreciable metal ion chelating activity at lower concentrations (10–40 μg/mL. Many extracts showed significant antioxidant response in beta carotene bleaching assay. AQ fraction of B. variegata showed pronounced cytotoxic effect against DU-145, HOP-62, IGR-OV-1, MCF-7, and THP-1 human cancer cell lines with 90–99% cell growth inhibitory activity. Ethyl acetate fraction also produced considerable cytotoxicity against MCF-7 and THP-1 cell lines. The study demonstrates notable antibacterial, antioxidant, and anticancer activities in B. variegata leaf extracts.

  9. 76 FR 5236 - Culturally Significant Objects Imported for Exhibition Determinations: “Upside Down Arctic...

    Science.gov (United States)

    2011-01-28

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Upside Down Arctic Realities... Down Arctic Realities,'' imported from abroad for temporary exhibition within the United States, are of cultural significance. The objects are imported pursuant to loan agreements with the foreign owners...

  10. Exhibition

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    China[Guangzheu] International Trade Fair for Home Textiles Date:March 18th- March 21st,2011 Venue:China Import and Export Fair Complex(Guangzhou,China) Organizers:China National Textile&Apparel Council China Foreign Trade Center(Group) China Home Textile Association China Foreign Trade Guangzhou Exhibition Corp.

  11. 76 FR 63701 - Culturally Significant Objects Imported for Exhibition Determinations: “Johan Zoffany RA: Society...

    Science.gov (United States)

    2011-10-13

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Johan Zoffany RA: Society Observed... determine that the objects to be included in the exhibition ``Johan Zoffany RA: Society Observed,'' imported... that the exhibition or display of the exhibit objects at the Yale Center for British Art, New...

  12. 78 FR 45285 - Culturally Significant Objects Imported for Exhibition Determinations: “Egypt's Mysterious Book...

    Science.gov (United States)

    2013-07-26

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Egypt's Mysterious Book of the..., 2003), I hereby determine that the objects to be included in the exhibition ``Egypt's Mysterious Book... custodians. I also determine that the exhibition or display of the exhibit objects at The Walters Art...

  13. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    A Look of Hope Islam Mahmoud Sweity From 19 to 30 June 2017 CERN Meyrin, Main Building Islam Mahmoud Sweity Islam Mahmoud Sweity was born in 1997 at Beit Awwa, Palestine. She is currently following a course to get an Art diploma of Painting at the college of Fine Arts at An-Najah National University under the supervision of Esmat Al As'aad. Her portraits, landscapes and still life paintings are full of life and shining colours. Charged of emotional empathy they catch the attention of the viewer and are reminding us that life is beautiful and worth living in spite of all difficulties we have to go through. She participated in many exhibitions and has exposed her drawings in 2015 at CERN and in France in the framework of the exhibition "The Origin“, and in 2017 in the Former Yugoslav Republic of Macedonia, Palestina and Jordan. In this exhibition the oil paintings made in the past year will be presented. For more information : staff.association@cern.ch | T&eacu...

  14. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    Encounters Hanne Blitz From February 1st to 12th 2016 CERN Meyrin, Main Building What is our reaction to a first encounter with a tourist attraction? Contemporary Dutch painter Hanne Blitz captures visitors' responses to art and architecture, sweeping vistas and symbolic memorials. Encounters, a series of oil paintings curated specially for this CERN exhibition, depicts tourists visiting cultural highlights around the world. A thought-provoking journey not to be missed, and a tip of the hat to CERN's large Hadron Collider.

  15. 78 FR 20372 - Culturally Significant Objects Imported for Exhibition Determinations: “Hall of Ancient Egypt”

    Science.gov (United States)

    2013-04-04

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Hall of Ancient Egypt'' SUMMARY... objects to be included in the exhibition ``Hall of Ancient Egypt,'' imported from abroad for temporary exhibition within the United States, are of cultural significance. The objects are imported pursuant to...

  16. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Sintropie Flavio Pellegrini From 13 to 24 March 2017 CERN Meyrin, Main Building Energia imprigionata - Flavio Pellegrini. The exhibition is composed by eleven wood artworks with the expression of movement as theme. The artworks are the result of harmonics math applied to sculpture. The powerful black colour is dominated by the light source, generating reflexes and modulations. The result is a continuous variation of perspective visions. The works generate, at a first approach, an emotion of mystery and incomprehension, only a deeper contemplation lets one discover entangling and mutative details, evidencing the elegance of the lines and letting the meaning emerge. For more information : staff.association@cern.ch | Tél: 022 766 37 38

  17. 78 FR 79058 - Culturally Significant Objects Imported for Exhibition Determinations: “Chinese Paintings from...

    Science.gov (United States)

    2013-12-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Chinese Paintings from Japanese..., 2003), I hereby determine that the objects to be included in the exhibition ``Chinese Paintings...

  18. 77 FR 48199 - Culturally Significant Objects Imported for Exhibition Determinations: “Bernini: Sculpting in Clay”

    Science.gov (United States)

    2012-08-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Bernini: Sculpting in Clay'' SUMMARY... objects to be included in the exhibition ``Bernini: Sculpting in Clay,'' imported from abroad...

  19. 78 FR 68134 - Culturally Significant Objects Imported for Exhibition Determinations: “Renaissance to Goya...

    Science.gov (United States)

    2013-11-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Renaissance to Goya: Prints and... ``Renaissance to Goya: Prints and Drawings from Spain,'' imported from abroad for temporary exhibition within...

  20. 76 FR 70805 - Culturally Significant Objects Imported for Exhibition Determinations: “The Renaissance Portrait...

    Science.gov (United States)

    2011-11-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Renaissance Portrait From... ``The Renaissance Portrait from Donatello to Bellini,'' imported from abroad for temporary exhibition...

  1. 75 FR 62916 - Culturally Significant Objects Imported for Exhibition Determinations: “India's Fabled City: The...

    Science.gov (United States)

    2010-10-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``India's Fabled City: The Art of... ``India's Fabled City: The Art of Courtly Lucknow,'' imported from abroad for temporary exhibition...

  2. 78 FR 17744 - Culturally Significant Objects Imported for Exhibition Determinations: “Maya: Hidden Worlds...

    Science.gov (United States)

    2013-03-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Maya: Hidden Worlds Revealed... determine that the objects to be included in the exhibition ``Maya: Hidden Worlds Revealed,'' imported...

  3. 75 FR 45195 - Culturally Significant Objects Imported for Exhibition Determinations: “Literary Lives: Portraits...

    Science.gov (United States)

    2010-08-02

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Literary Lives: Portraits From the... that the objects to be included in the exhibition ``Literary Lives: Portraits from the Crawford...

  4. 76 FR 58075 - Culturally Significant Object Imported for Exhibition Determinations: “Cervera Bible”

    Science.gov (United States)

    2011-09-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Cervera Bible'' SUMMARY: Notice is... object to be included in the exhibition ``Cervera Bible,'' imported from abroad for temporary...

  5. 76 FR 4987 - Culturally Significant Objects Imported for Exhibition Determinations: “Bali: Art, Ritual...

    Science.gov (United States)

    2011-01-27

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Bali: Art, Ritual, Performance..., Ritual, Performance,'' imported from abroad for temporary exhibition within the United States, are...

  6. 77 FR 61468 - Culturally Significant Objects Imported for Exhibition Determinations: “Balthus: Cats and Girls”

    Science.gov (United States)

    2012-10-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Balthus: Cats and Girls'' SUMMARY... objects to be included in the exhibition ``Balthus: Cats and Girls,'' imported from abroad for...

  7. 78 FR 1916 - Culturally Significant Objects Imported for Exhibition; Determinations: “Impressionism, Fashion...

    Science.gov (United States)

    2013-01-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition; Determinations: ``Impressionism, Fashion, and..., 2003), I hereby determine that the objects to be included in the exhibition ``Impressionism, Fashion...

  8. 76 FR 12786 - Culturally Significant Objects Imported for Exhibition Determinations: “Charlotte Salomon: Life...

    Science.gov (United States)

    2011-03-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Charlotte Salomon: Life? Or Theatre... Salomon: Life? Or Theatre?'' imported from abroad for temporary exhibition within the United States,...

  9. 76 FR 29286 - Culturally Significant Objects Imported for Exhibition Determinations: “Pissarro's People”

    Science.gov (United States)

    2011-05-20

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Pissarro's People'' SUMMARY: Notice..., I hereby determine that the objects to be included in the exhibition ``Pissarro's People,''...

  10. 76 FR 15358 - Culturally Significant Objects Imported for Exhibition Determinations: “Before the Pyramids: The...

    Science.gov (United States)

    2011-03-21

    ... ``Before the Pyramids: The Origins of Egyptian Civilization'' imported from abroad for temporary exhibition... Culturally Significant Objects Imported for Exhibition Determinations: ``Before the Pyramids: The Origins of Egyptian Civilization'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to...

  11. 77 FR 39319 - Culturally Significant Objects Imported for Exhibition Determinations: “Bodies and Shadows...

    Science.gov (United States)

    2012-07-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Bodies and Shadows: Caravaggio and...: Caravaggio and His Legacy'' imported from abroad for temporary exhibition within the United States, are...

  12. 78 FR 28274 - Culturally Significant Objects Imported for Exhibition Determinations: “Medieval Treasures from...

    Science.gov (United States)

    2013-05-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Medieval Treasures from Hildesheim... determine that the objects to be included in the exhibition ``Medieval Treasures from Hildesheim,''...

  13. 78 FR 61981 - Culturally Significant Objects Imported for Exhibition Determinations: “Anders Zorn: Sweden's...

    Science.gov (United States)

    2013-10-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Anders Zorn: Sweden's Master Painter... determine that the objects to be included in the exhibition ``Anders Zorn: Sweden's Master...

  14. 76 FR 12786 - Culturally Significant Objects Imported for Exhibition Determinations: “Poetry in Clay: Korean...

    Science.gov (United States)

    2011-03-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Poetry in Clay: Korean Buncheong... objects to be included in the exhibition ``Poetry in Clay: Korean Buncheong Ceramics from the...

  15. 75 FR 80885 - Culturally Significant Objects Imported for Exhibition Determinations: “The Buddhist Heritage of...

    Science.gov (United States)

    2010-12-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Buddhist Heritage of Pakistan... Buddhist Heritage of Pakistan,'' imported from abroad for temporary exhibition within the United...

  16. 75 FR 17197 - Culturally Significant Objects Imported for Exhibition Determinations: “Cyprus: Crossroads of...

    Science.gov (United States)

    2010-04-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Cyprus: Crossroads of Civilizations... that the objects to be included in the exhibition ``Cyprus: Crossroads of Civilizations,''...

  17. 75 FR 38589 - Culturally Significant Objects Imported for Exhibition Determinations: “Salvador Dali: The Late...

    Science.gov (United States)

    2010-07-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Salvador Dali: The Late Work... that the objects to be ] included in the exhibition ``Salvador Dali: The Late Work,'' imported...

  18. 77 FR 4614 - Culturally Significant Objects Imported for Exhibition Determinations: “Children of the Plumed...

    Science.gov (United States)

    2012-01-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Children of the Plumed Serpent: The... exhibition ``Children of the Plumed Serpent: The Legacy of Quetzalcoatl in Ancient Mexico,'' imported...

  19. 77 FR 32711 - Culturally Significant Objects Imported for Exhibition Determinations: “Messerschmidt and Modernity”

    Science.gov (United States)

    2012-06-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Messerschmidt and Modernity... ``Messerschmidt and Modernity,'' imported from abroad for temporary exhibition within the United States, are of...

  20. 78 FR 48925 - Culturally Significant Object Imported for Exhibition Determinations: “Violence and Virtue...

    Science.gov (United States)

    2013-08-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Violence and Virtue: Artemisia... April 15, 2003), I hereby determine that the object to be included in the exhibition ``Violence...

  1. 75 FR 51518 - Culturally Significant Objects Imported for Exhibition Determinations: “Ballplayers, Gods, and...

    Science.gov (United States)

    2010-08-20

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Ballplayers, Gods, and Rainmaker... objects to be included in the exhibition ``Ballplayers, Gods, and Rainmaker Kings: Masterpieces...

  2. 76 FR 53993 - Culturally Significant Objects Imported for Exhibition Determinations: “New Photography 2011...

    Science.gov (United States)

    2011-08-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``New Photography 2011: Zhang Dali... objects to be included in the exhibition ``New Photography 2011: Zhang Dali, Moyra Davey, George...

  3. 77 FR 50542 - Culturally Significant Objects Imported for Exhibition Determinations: “New Photography 2012...

    Science.gov (United States)

    2012-08-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``New Photography 2012: Michele Abeles... objects to be included in the exhibition ``New Photography 2012: Michele Abeles, Birdhead (Ji Weiyu...

  4. 78 FR 40544 - Culturally Significant Objects Imported for Exhibition Determinations: “New Photography 2013...

    Science.gov (United States)

    2013-07-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``New Photography 2013: Adam Broomberg..., 2003), I hereby determine that the objects to be included in the exhibition ``New Photography...

  5. 78 FR 71022 - Culturally Significant Objects Imported for Exhibition Determinations: “Christopher Williams: The...

    Science.gov (United States)

    2013-11-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Christopher Williams: The Production..., 2003), I hereby determine that the objects to be included in the exhibition ``Christopher Williams:...

  6. 78 FR 8682 - Culturally Significant Object Imported for Exhibition Determinations: “Vermeer's Woman in Blue...

    Science.gov (United States)

    2013-02-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Vermeer's Woman in Blue Reading a... ``Vermeer's Woman in Blue Reading a Letter,'' imported from abroad for temporary exhibition within...

  7. 76 FR 20802 - Culturally Significant Object Imported for Exhibition Determinations: “The Capitoline Venus”

    Science.gov (United States)

    2011-04-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``The Capitoline Venus'' SUMMARY..., I hereby determine that the object to be included in the exhibition ``The Capitoline...

  8. 76 FR 23642 - Culturally Significant Objects Imported for Exhibition Determinations: “Projects 95: Runa Islam”

    Science.gov (United States)

    2011-04-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Projects 95: Runa Islam'' SUMMARY..., I hereby determine that the objects to be included in the exhibition ``Projects 95: Runa...

  9. 76 FR 12399 - Culturally Significant Objects Imported for Exhibition Determinations: “Paris: Life & Luxury”

    Science.gov (United States)

    2011-03-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Paris: Life & Luxury'' SUMMARY..., I hereby determine that the objects to be included in the exhibition ``Paris: Life &...

  10. 76 FR 14115 - Culturally Significant Objects Imported for Exhibition Determinations: “Assorted Greek and Roman...

    Science.gov (United States)

    2011-03-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Assorted Greek and Roman Objects... Greek and Roman Objects'' imported from abroad for temporary exhibition within the United States, are...

  11. 75 FR 57825 - Culturally Significant Objects Imported for Exhibition Determinations: “Ancient Chinese Bronzes...

    Science.gov (United States)

    2010-09-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Ancient Chinese Bronzes From the... objects to be included in the exhibition ``Ancient Chinese Bronzes from the Shouyang Studio: The...

  12. 75 FR 15764 - Culturally Significant Objects Imported for Exhibition Determinations: “Gods of Angkor: Bronzes...

    Science.gov (United States)

    2010-03-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Gods of Angkor: Bronzes From the...: Bronzes from the National Museum of Cambodia,'' imported from abroad for temporary exhibition within...

  13. 75 FR 74768 - Culturally Significant Objects Imported for Exhibition Determinations: “Norwegian Painters”

    Science.gov (United States)

    2010-12-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Norwegian Painters'' SUMMARY: Notice..., I hereby determine that the objects to be included in the exhibition ``Norwegian...

  14. 77 FR 23318 - Culturally Significant Object Imported for Exhibition Determinations: “African Cosmos: Stellar Arts”

    Science.gov (United States)

    2012-04-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``African Cosmos: Stellar Arts... Cosmos: Stellar Arts,'' imported from abroad for temporary exhibition within the United States, is...

  15. 75 FR 45194 - Culturally Significant Objects Imported for Exhibition Determinations: “Drawing from Nature...

    Science.gov (United States)

    2010-08-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Drawing from Nature: Landscapes by... objects to be included in the exhibition ``Drawing from Nature: Landscapes by Max Liebermann, Lovis...

  16. 77 FR 34121 - Culturally Significant Objects Imported for Exhibition Determinations: “Lucian Freud: Portraits”

    Science.gov (United States)

    2012-06-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Lucian Freud: Portraits'' SUMMARY... object to be included in the exhibition ``Lucian Freud: Portraits,'' imported from abroad by The Modern...

  17. 75 FR 48736 - Culturally Significant Objects Imported for Exhibition Determinations: “Kurt Schwitters: Color...

    Science.gov (United States)

    2010-08-11

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Kurt Schwitters: Color and Collage... Schwitters: Color and Collage,'' imported from abroad for temporary exhibition within the United States,...

  18. 75 FR 25031 - Culturally Significant Objects Imported for Exhibition Determinations: “Tiffany: Color and Light”

    Science.gov (United States)

    2010-05-06

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Tiffany: Color and Light'' SUMMARY... included in the exhibition ``Tiffany: Color and Light,'' imported from abroad for temporary...

  19. 78 FR 4972 - Culturally Significant Objects Imported for Exhibition Determinations: “Chagall: Beyond Color”

    Science.gov (United States)

    2013-01-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Chagall: Beyond Color'' SUMMARY... objects to be included in the exhibition ``Chagall: Beyond Color,'' imported from abroad for...

  20. 77 FR 61045 - Culturally Significant Objects Imported for Exhibition Determinations: “China's Terracotta...

    Science.gov (United States)

    2012-10-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``China's Terracotta Warriors: The... Terracotta Warriors: The First Emperor's Legacy,'' imported from abroad for temporary exhibition within...

  1. 75 FR 1680 - Culturally Significant Objects Imported for Exhibition Determinations: “Roman Art”

    Science.gov (United States)

    2010-01-12

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Roman Art'' SUMMARY: Notice is... included in the exhibition ``Roman Art,'' imported from abroad for temporary exhibition within the United... the Metropolitan Museum of Art, New York, NY, from on or about January 2010 until on or about...

  2. 77 FR 22833 - Culturally Significant Objects Imported for Exhibition Determinations: “Edouard Vuillard: A...

    Science.gov (United States)

    2012-04-17

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Edouard Vuillard: A Painter and His... pertaining to the exhibit ``Edouard Vuillard: A Painter and His Muses, 1890-1940.'' The reference notice is... exhibition ``Edouard Vuillard: A Painter and His Muses, 1890-1940,'' imported from abroad for temporary...

  3. 78 FR 26682 - Culturally Significant Objects Imported for Exhibition Determinations: “Hall of Ancient Egypt”

    Science.gov (United States)

    2013-05-07

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Hall of Ancient Egypt'' AGENCY... pertaining to the exhibition ``Hall of Ancient Egypt.'' The referenced notice is corrected here to include... April 15, 2003), I hereby determine that the additional objects to be included in the exhibition...

  4. 77 FR 4858 - Culturally Significant Objects Imported for Exhibition Determinations: “Byzantium and Islam: Age...

    Science.gov (United States)

    2012-01-31

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Byzantium and Islam: Age of... determinations made by ] the Department of State pertaining to the exhibition ``Byzantium and Islam: Age of... Islam: Age of Transition (7th-9th Century),'' imported from abroad for temporary exhibition within...

  5. Aqueous extracts of microalgae exhibit antioxidant and anticancer activities

    Institute of Scientific and Technical Information of China (English)

    Sanaa MM Shanab; Soha SM Mostafa; Emad A Shalaby; Ghada I Mahmoud

    2012-01-01

    Objective: To investigate the antioxidant and anticancer activities of aqueous extracts of nine microalgal species. Methods: Variable percentages of major secondary metabolites (total phenolic content, terpenoids and alkaloids) as well as phycobiliprotein pigments (phycocyanin, allophycocyanin and phycoerythrin) in the aqueous algal extracts were recorded. Antioxidant activity of the algal extracts was performed using 2, 2 diphenyl-1-picrylhydrazyl (DPPH) test and 2,2'-azino-bis (ethylbenzthiazoline-6-sulfonic acid (ABTS.+) radical cation assay. Anticancer efficiency of the algal water extracts was investigated against Ehrlich Ascites Carcinoma cell (EACC) and Human hepatocellular cancer cell line (HepG2). Results: Antioxidant activity of the algal extracts was performed using DPPH test and ABTS.+ radical cation assays which revealed 30.1-72.4% and 32.0-75.9% respectively. Anticancer efficiency of the algal water extracts was investigated against Ehrlich Ascites Carcinoma Cell (EACC) and Human Hepatocellular cancer cell line (HepG2) with an activity ranged 87.25% and 89.4% respectively. Culturing the promising cyanobacteria species; Nostocmuscorum and Oscillatoria sp. under nitrogen stress conditions (increasing and decreasing nitrate content of the normal BG11 medium, 1.5 g/L), increased nitrate concentration (3, 6 and 9 g/L) led to a remarkable increase in phycobilin pigments followed by an increase in both antioxidant and anticancer activities in both cyanobacterial species. While the decreased nitrate concentration (0.75, 0.37 and 0.0 g/L) induced an obvious decrease in phycobilin pigments with complete absence of allophycocyanin in case of Oscillatoria sp. Conclusions: Nitrogen starvation (0.00 g/L nitrate) induced an increase and comparable antioxidant and anticancer activities to those cultured in the highest nitrate content.

  6. 75 FR 57825 - Culturally Significant Objects Imported for Exhibition Determinations: “Artifacts From Auschwitz...

    Science.gov (United States)

    2010-09-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Artifacts From Auschwitz-Birkenau... of August 28, 2000, I hereby determine that the objects to be included in the exhibition...

  7. 78 FR 33465 - Culturally Significant Objects Imported for Exhibition Determinations: “Interwoven Globe: The...

    Science.gov (United States)

    2013-06-04

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Interwoven Globe: The Worldwide... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Interwoven Globe...

  8. 77 FR 53959 - Culturally Significant Object Imported for Exhibition Determinations: “Dancing Into Dreams, Maya...

    Science.gov (United States)

    2012-09-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Dancing Into Dreams, Maya Vases From..., 2003), I hereby determine that the object to be included in the exhibition ``Dancing Into Dreams,...

  9. 75 FR 18252 - Culturally Significant Object Imported for Exhibition Determinations: “Through African Eyes: The...

    Science.gov (United States)

    2010-04-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Through African Eyes: The European in... 15, 2003 , I hereby determine that the object to be included in the exhibition ``Through African...

  10. 78 FR 53817 - Culturally Significant Objects Imported for Exhibition Determinations: “Venetian Glass by Carlo...

    Science.gov (United States)

    2013-08-30

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Venetian Glass by Carlo Scarpa: The... April 15, 2003, I hereby determine that the objects to be included in the exhibition ``Venetian Glass by...

  11. 76 FR 28121 - Culturally Significant Objects Imported for Exhibition Determinations: “National Geographic...

    Science.gov (United States)

    2011-05-13

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``National Geographic Treasures of the... ``National Geographic Treasures of the Earth'' imported from abroad for temporary exhibition within the...), is in the national interest. The Museum understands that immediately after the last day of the...

  12. 76 FR 58075 - Culturally Significant Objects Imported for Exhibition Determinations: “Rembrandt and Degas: Two...

    Science.gov (United States)

    2011-09-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Rembrandt and Degas: Two Young..., 2003), I hereby determine that the objects to be included in the exhibition ``Rembrandt and Degas: Two...

  13. 78 FR 24288 - Culturally Significant Objects Imported for Exhibition Determinations: “Frida Kahlo, Diego Rivera...

    Science.gov (United States)

    2013-04-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Frida Kahlo, Diego Rivera, and... included in the exhibition ``Frida Kahlo, Diego Rivera, and Masterpieces of Modern Mexico: The Jacques and...

  14. 75 FR 28848 - Culturally Significant Objects Imported for Exhibition Determinations: “The Original Copy...

    Science.gov (United States)

    2010-05-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Original Copy: Photography of... hereby determine that the objects to be included in the exhibition ``The Original Copy: Photography of...

  15. 76 FR 56864 - Culturally Significant Objects Imported for Exhibition Determinations: “Caravaggio and His...

    Science.gov (United States)

    2011-09-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Caravaggio and His Followers in Rome... determine that the objects to be included in the exhibition ``Caravaggio and His Followers in...

  16. 77 FR 56697 - Culturally Significant Object Imported for Exhibition Determinations: “Steve McQueen”

    Science.gov (United States)

    2012-09-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Steve McQueen'' SUMMARY: Notice is... object to be included in the exhibition ``Steve McQueen,'' imported from abroad for temporary...

  17. 78 FR 52997 - Culturally Significant Objects Imported for Exhibition Determinations: “Yoga: the Art of...

    Science.gov (United States)

    2013-08-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Yoga: the Art of Transformation... determine that the objects to be included in the exhibition ``Yoga: the Art of Transformation,'' imported...

  18. 75 FR 30459 - Culturally Significant Objects Imported for Exhibition Determinations: “Dynasty and Divinity: Ife...

    Science.gov (United States)

    2010-06-01

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Dynasty and Divinity: Ife Art in... hereby determine that the objects to be included in the exhibition ``Dynasty and Divinity: Ife Art...

  19. 75 FR 7536 - Culturally Significant Objects Imported for Exhibition Determinations: “The Dead Sea Scrolls...

    Science.gov (United States)

    2010-02-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Dead Sea Scrolls: Words That... hereby determine that the objects to be included in the exhibition ``The Dead Sea Scrolls: Words...

  20. 77 FR 64373 - Culturally Significant Objects Imported for Exhibition Determinations: “The Dead Sea Scrolls...

    Science.gov (United States)

    2012-10-19

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Dead Sea Scrolls: Life and Faith in Ancient Times,'' Formerly Titled ``The Dead Sea Scrolls: Life and Faith in Biblical Times... the exhibition ``The Dead Sea Scrolls: Life and Faith in Biblical Times.'' The referenced notice...

  1. 78 FR 24462 - Culturally Significant Objects Imported for Exhibition; Determinations: “The Dead Sea Scrolls...

    Science.gov (United States)

    2013-04-25

    ... Culturally Significant Objects Imported for Exhibition; Determinations: ``The Dead Sea Scrolls: Life and Faith in Ancient Times'' Formerly Titled ``The Dead Sea Scrolls: Life and Faith in Biblical Times... the exhibition ``The Dead Sea Scrolls: Life and Faith in Biblical Times.'' The referenced notice...

  2. 78 FR 62354 - Culturally Significant Objects Imported for Exhibition Determinations: “The Dead Sea Scrolls...

    Science.gov (United States)

    2013-10-18

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Dead Sea Scrolls: Life and Faith in Ancient Times'' Formerly Titled ``The Dead Sea Scrolls: Life and Faith in Biblical Times'' ACTION... exhibition ``The Dead Sea Scrolls: Life and Faith in Biblical Times.'' The referenced notice was corrected...

  3. 78 FR 16565 - Culturally Significant Objects Imported for Exhibition Determinations: “The Dead Sea Scrolls...

    Science.gov (United States)

    2013-03-15

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``The Dead Sea Scrolls: Life and Faith in Ancient Times'' Formerly Titled ``The Dead Sea Scrolls: Life and Faith in Biblical Times'' ACTION... exhibition ``The Dead Sea Scrolls: Life and Faith in Biblical Times.'' The referenced notice was corrected...

  4. 77 FR 36329 - Culturally Significant Objects Imported for Exhibition Determinations: “Dead Sea Scrolls & The...

    Science.gov (United States)

    2012-06-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Dead Sea Scrolls & The Bible Ancient... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Dead Sea...

  5. 77 FR 21142 - Culturally Significant Objects Imported for Exhibition Determinations: “Edouard Vuillard: A...

    Science.gov (United States)

    2012-04-09

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Edouard Vuillard: A Painter and His..., 2003), I hereby determine that the objects to be included in the exhibition ``Edouard Vuillard: A...

  6. 77 FR 28419 - Culturally Significant Objects Imported for Exhibition Determinations: “Gustav Klimt: The Magic...

    Science.gov (United States)

    2012-05-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Gustav Klimt: The Magic of Line... determine that the objects to be included in the exhibition ``Gustav Klimt: The Magic of Line,''...

  7. 75 FR 7536 - Culturally Significant Objects Imported for Exhibition Determinations: “The Aztec Pantheon and...

    Science.gov (United States)

    2010-02-19

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Aztec Pantheon and the Art... hereby determine that the objects to be included in the exhibition ``The Aztec Pantheon and the Art...

  8. 76 FR 39974 - Culturally Significant Objects Imported for Exhibition Determinations: “Warhol: The Headlines”

    Science.gov (United States)

    2011-07-07

    ..., from on or about September 25, 2011, until on or about January 2, 2012, at The Andy Warhol Museum... Culturally Significant Objects Imported for Exhibition Determinations: ``Warhol: The Headlines'' SUMMARY..., I hereby determine that the objects to be included in the exhibition ``Warhol: The...

  9. 77 FR 38881 - Culturally Significant Objects Imported for Exhibition Determinations: “Regarding Warhol: Sixty...

    Science.gov (United States)

    2012-06-29

    ...; then at the Andy Warhol Museum in Pittsburgh, Pennsylvania from on or about February 2, 2013 to on or... Culturally Significant Objects Imported for Exhibition Determinations: ``Regarding Warhol: Sixty Artists..., 2003), I hereby determine that the objects to be included in the exhibition ``Regarding Warhol:...

  10. 77 FR 48198 - Culturally Significant Objects Imported for Exhibition Determinations: “Faking It: Manipulated...

    Science.gov (United States)

    2012-08-13

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Faking It: Manipulated Photography... Photography Before Photoshop,'' imported from abroad for temporary exhibition within the United States, are of... of Art, New York, New York, from on or about October 11, 2012, until on or about January 27,...

  11. 77 FR 2340 - Culturally Significant Objects Imported for Exhibition Determinations: “Snapshot: Painters and...

    Science.gov (United States)

    2012-01-17

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Snapshot: Painters and Photography... Photography, Bonnard to Vuillard'' imported from abroad for temporary exhibition within the United States, are... Indianapolis Museum of Art, Indianpolis, IN, from on or about June 8, 2012, until on or about September 2,...

  12. 77 FR 34455 - Culturally Significant Objects Imported for Exhibition Determinations: “Century of the Child...

    Science.gov (United States)

    2012-06-11

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Century of the Child: Growing by..., 2003), I hereby determine that the objects to be included in the exhibition ``Century of the Child... Museum of Modern Art, New York, NY, from on or about July 29, 2012, until on or about November 5,...

  13. 75 FR 7536 - Culturally Significant Objects Imported for Exhibition Determinations: “Hendrick Avercamp (1585...

    Science.gov (United States)

    2010-02-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Hendrick Avercamp (1585-1634): The... hereby determine that the objects to be included in the exhibition ``Hendrick Avercamp (1585-1634): The...

  14. 77 FR 12103 - Culturally Significant Objects Imported for Exhibition Determinations: “Colorful Realm: Japanese...

    Science.gov (United States)

    2012-02-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Colorful Realm: Japanese Bird-and... exhibition ``Colorful Realm: Japanese Bird-and-Flower Paintings by It Jakuch (1716-1800),'' imported...

  15. 76 FR 5236 - Culturally Significant Objects Imported for Exhibition Determinations: “Pastel Portraits: Images...

    Science.gov (United States)

    2011-01-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Pastel Portraits: Images of 18th... ``Pastel Portraits: Images of 18th-Century Europe,'' imported from abroad for temporary exhibition...

  16. 76 FR 60112 - Culturally Significant Objects Imported for Exhibition Determinations: “Byzantium and Islam: Age...

    Science.gov (United States)

    2011-09-28

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Byzantium and Islam: Age of... Islam: Age of Transition (7th-9th Century),'' imported from abroad for temporary exhibition within...

  17. 75 FR 13806 - Culturally Significant Objects Imported for Exhibition Determinations: “Loan From the Aura...

    Science.gov (United States)

    2010-03-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Loan From the Aura Collection of a... hereby determine that the object to be included in the exhibition ``Loan from the Aura Collection of...

  18. 78 FR 11725 - Culturally Significant Objects Imported for Exhibition Determinations: “Claes Oldenburg: The...

    Science.gov (United States)

    2013-02-19

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Claes Oldenburg: The Street and The... Street and The Store,'' imported from abroad for temporary exhibition within the United States, are of... Art, New York, New York, from on or about April 14, 2013, until on or about August 5, 2013, the Walker...

  19. 78 FR 11264 - Culturally Significant Objects Imported for Exhibition Determinations: “The Cyrus Cylinder in...

    Science.gov (United States)

    2013-02-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Cyrus Cylinder in Ancient Persia... Ancient Persia: A New Beginning,'' imported from abroad for temporary exhibition within the United States...

  20. 77 FR 7229 - Culturally Significant Objects Imported for Exhibition Determinations: “Nomads and Networks: The...

    Science.gov (United States)

    2012-02-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Nomads and Networks: The Ancient Art... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Nomads...

  1. 77 FR 37730 - Culturally Significant Objects Imported for Exhibition Determinations: “Nomads and Networks: The...

    Science.gov (United States)

    2012-06-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Nomads and Networks: The Ancient Art... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``Nomads...

  2. 78 FR 50137 - Culturally Significant Objects Imported for Exhibition Determinations: “Chagall: Love, War, and...

    Science.gov (United States)

    2013-08-16

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Chagall: Love, War, and Exile... determine that the objects to be included in the exhibition ``Chagall: Love, War, and Exile,'' imported from...

  3. 78 FR 5556 - Culturally Significant Objects Imported for Exhibition Determinations: “Frida & Diego: Passion...

    Science.gov (United States)

    2013-01-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Frida & Diego: Passion, Politics and..., 2003), I hereby determine that the objects to be included in the exhibition ``Frida & Diego: Passion...

  4. 78 FR 60994 - Culturally Significant Objects Imported for Exhibition Determinations: “In Grand Style...

    Science.gov (United States)

    2013-10-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``In Grand Style: Celebrations in... April 15, 2003), I hereby determine that the objects to be included in the exhibition ``In Grand...

  5. 77 FR 15839 - Culturally Significant Objects Imported for Exhibition Determinations: “Making a Presence: F...

    Science.gov (United States)

    2012-03-16

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Making a Presence: F. Holland Day in.... Holland Day in Artistic Photography,'' imported from abroad for temporary exhibition within the United... of Educational and Cultural Affairs, Department of State. BILLING CODE 4710-05-P ...

  6. 75 FR 5637 - Culturally Significant Objects Imported for Exhibition Determinations: “Architecture as Icon...

    Science.gov (United States)

    2010-02-03

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Architecture as Icon: Perception and... Icon: Perception and Representation of Architecture in Byzantine Art,'' imported from abroad...

  7. 76 FR 23642 - Culturally Significant Objects Imported for Exhibition Determinations: “Marajo: Ancient Ceramics...

    Science.gov (United States)

    2011-04-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Marajo: Ancient Ceramics at the... ``Marajo: Ancient Ceramics at the Mouth of the Amazon'' imported from abroad for temporary...

  8. 78 FR 18664 - Culturally Significant Objects Imported for Exhibition Determinations: “Diaghilev and the Ballets...

    Science.gov (United States)

    2013-03-27

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Diaghilev and the Ballets Russes... the Ballets Russes, 1909- 1929: When Art Danced with Music,'' imported from abroad for...

  9. 76 FR 53705 - Culturally Significant Objects Imported for Exhibition; Determinations: “Seductive Luxury and...

    Science.gov (United States)

    2011-08-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition; Determinations: ``Seductive Luxury and Innovation... ``Seductive Luxury and Innovation: The Furniture of Abraham and David Roentgen,'' imported from abroad...

  10. 77 FR 41473 - Culturally Significant Objects Imported for Exhibition Determinations: “Lion Attacking a Horse”

    Science.gov (United States)

    2012-07-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Lion Attacking a Horse'' SUMMARY... object entitled ``Lion Attacking a Horse,'' to be imported by The J. Paul Getty Museum from abroad...

  11. 76 FR 49832 - Culturally Significant Object Imported for Exhibition Determinations: “Warhol: The Headlines”

    Science.gov (United States)

    2011-08-11

    ... about January 2, 2012, at The Andy Warhol Museum, Pittsburgh, Pennsylvania, from on or about October 14... Culturally Significant Object Imported for Exhibition Determinations: ``Warhol: The Headlines'' ACTION..., ``Warhol: The Headlines.'' The referenced notice is corrected to add one additional object to be...

  12. 76 FR 81004 - Culturally Significant Objects Imported for Exhibition Determinations: “Woman in Blue, Against...

    Science.gov (United States)

    2011-12-27

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Woman in Blue, Against Blue Water..., 2003), I hereby determine that the object ``Woman in Blue, Against Blue Water'' by Edvard...

  13. 77 FR 48582 - Culturally Significant Objects Imported for Exhibition Determinations: Terracotta Bell-Krater...

    Science.gov (United States)

    2012-08-14

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: Terracotta Bell-Krater Attributed to..., 2003), I hereby determine that the object Terracotta Bell-Krater attributed to the Altamura...

  14. 75 FR 43225 - Culturally Significant Objects Imported for Exhibition Determinations: “Man, Myth, and Sensual...

    Science.gov (United States)

    2010-07-23

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No. 236-3 of August 28, 2000, I hereby determine that the objects to be included in the exhibition ``Man, Myth, and Sensual Pleasures: Jan Gossart's Renaissance,'' imported from abroad for temporary exhibition within the United States, are of cultural significance. The objects are imported pursuant to loan agreements with the foreign owners or custodians. I also determine that the exhibition or display of the exhibit objects at the Metropolitan Museum of Art, New York, NY, from on or about October 5, 2010, until on or about January 17, 2011, and at possible additional exhibitions or venues yet to be determined, is in the national interest. Public Notice of these Determinations is ordered to be published in the Federal Register.

  15. 77 FR 54647 - Culturally Significant Objects Imported for Exhibition Determinations: “Manet: Portraying Life”

    Science.gov (United States)

    2012-09-05

    ... Imported for Exhibition Determinations: ``Manet: Portraying Life'' SUMMARY: Notice is hereby given of the... exhibition ``Manet: Portraying Life,'' imported from abroad for temporary exhibition within the United...

  16. Methanol leaves extract Hibiscus micranthus Linn exhibited antibacterial and wound healing activities.

    Science.gov (United States)

    Begashaw, Berhan; Mishra, Bharat; Tsegaw, Asegedech; Shewamene, Zewdneh

    2017-06-26

    Infectious diseases are the most common causes of morbidity and mortality in developing countries. Wound and wound infections are also major health problem. Nowadays, medicinal plants play a major role in treatment of infectious diseases and wound healing and they are easily available and more affordable as compared to synthetic compounds. The aim of this study is therefore, to investigate the antibacterial and wound healing activities of 80% methanol extract of Hibiscus micranthus leaves using disc diffusion methods and rat excision model respectively. In vitro antibacterial screening was carried out against S. aureus, S.pneumoniae, S. pyogenes, E. coli, P. aeruginosa, K. pneumoniae and P. mirabilis bacterial strains using disc-well diffusion assay. Would healing activity was done in rats divided into four groups each consisting of six animals. Group I was served as a negative control (ointment base), Group II served as a positive control Nitrofurazone (NFZ 0.2% ointment), Groups III and IV was treated 5 and 10% extracts respectively. The acute oral toxicity test and skin sensitivity test were also performed before conducting the actual study. The extract was analyzed for secondary metabolites using standard methods. Preliminary phytochemical screening have revealed the presence of alkaloids, flavonoids, saponins, tannins, steroids, phenols, diterpines, anthraquinones and the absence of glycosides, terpinoides and triterpines. Based on acute oral toxicity test the extract was found to be safe up to a dose of 2 g/kg. In addition, acute dermal toxicity test indicated no sign of skin irritation. The leaves extract exhibited varying degrees of sensitivity with zones of inhibition ranging from 14.00 ± 0.333 (S.pyogenes) to 22.67 ± 1.202 mm (S.aureus). It was found that S. aureus and S. pneumonia (p wound healing study, the 5 and 10% w/w extract exhibited significant wound contraction rate of 99.30% and 99.13% as compared to NFZ ointment and simple ointment

  17. 78 FR 48216 - Culturally Significant Objects Imported for Exhibition Determinations: “Balthus: Cats and Girls...

    Science.gov (United States)

    2013-08-07

    ... for Exhibition Determinations: ``Balthus: Cats and Girls--Paintings and Provocations'' SUMMARY: Notice..., I hereby determine that the objects to be included in the exhibition ``Balthus: Cats and...

  18. 77 FR 56698 - Culturally Significant Objects Imported for Exhibition Determinations: “Opera Nobile...

    Science.gov (United States)

    2012-09-13

    ... for Exhibition Determinations: ``Opera Nobile: Masterpieces From Ancient Italy'' SUMMARY: Notice is... objects to be included in the exhibition ``Opera Nobile: Masterpieces from Ancient Italy,'' imported...

  19. 75 FR 53731 - Culturally Significant Objects Imported for Exhibition Determinations: “Contemporary Argentine...

    Science.gov (United States)

    2010-09-01

    ... for Exhibition Determinations: ``Contemporary Argentine Masterworks'' SUMMARY: Notice is hereby given... hereby determine that the objects to be included in the exhibition ``Contemporary Argentine...

  20. Dynamics of hypersonic flight vehicles exhibiting significant aeroelastic and aeropropulsive interactions

    Science.gov (United States)

    Chavez, Frank R.; Schmidt, David K.

    1993-01-01

    With analytic expressions previously developed for the forces and moments acting on a generic hypersonic vehicle, it is of interest to investigate the relative importance of the aerodynamic and propulsive effects on the vehicle dynamics. It is shown that the vehicle's aerodynamics and propulsive forces are both very significant in the evaluation of key stability derivatives which dictate the vehicle's dynamic characteristics. It is also shown that the vehicle model selected is unstable in pitch and exhibits strong airframe/engine/elastic coupling. With the use of literal expressions for both the systems poles and zeros, as well as the stability derivatives, key vehicle dynamic characteristics are investigated. For small errors, or uncertainties, in either the aerodynamic or propulsive forces, significant errors in the frequency and damping of the dominant modes and zero locations will arise.

  1. Juglans mandshurica Maxim extracts exhibit antitumor activity on HeLa cells in vitro.

    Science.gov (United States)

    Xin, Nian; Hasan, Murtaza; Li, Wei; Li, Yan

    2014-04-01

    The present study examined the potential application of Juglans mandshurica Maxim extracts (HT) for cancer therapy by assessing their anti‑proliferative activity, reduction of telomerase activity, induction of apoptosis and cell cycle arrest in S phase in HeLa cells. From the perspective of using HT as a herbal medicine, photomicroscopy and florescent microscopy techniques were utilized to characterize the effect of the extracts on telomerase activity and cell morphology. Flow cytometry was employed to study apoptosis and cell cycle of HeLa cells, and DNA laddering was performed. The results showed that HT inhibited cell proliferation and telomerase activity, induced apoptosis and caused S phase arrest of HeLa cells in vitro. HT inhibited HeLa cell proliferation significantly, and the highest inhibition rate was 83.7%. A trap‑silver staining assay showed that HT was capable of markedly decreasing telomerase activity of HeLa cells and this inhibition was enhanced in a time‑ and dose‑dependent manner. Results of a Hoechst 33258 staining assay showed that HeLa cells treated by HT induced cell death. Through DNA agarose gel electrophoresis, DNA ladders of HeLa cells treated with HT were observed, indicating apoptosis. In conclusion, the present study demonstrated that HT exhibited anti‑tumor effects comprising the inhibition of growth and telomerase activity as well as apoptosis and cell cycle arrest in HeLa cells.

  2. 76 FR 63701 - Culturally Significant Objects Imported for Exhibition Determinations: “Diego Rivera: Murals for...

    Science.gov (United States)

    2011-10-13

    ... Imported for Exhibition Determinations: ``Diego Rivera: Murals for the Museum of Modern Art'' SUMMARY... objects to be included in the exhibition ``Diego Rivera: Murals for The Museum of Modern Art,'' imported...

  3. 78 FR 39435 - Culturally Significant Objects Imported for Exhibition; Determinations: “Magritte: The Mystery of...

    Science.gov (United States)

    2013-07-01

    ... Exhibition; Determinations: ``Magritte: The Mystery of the Ordinary, 1926-1938'' SUMMARY: Notice is hereby... objects to be included in the exhibition ``Magritte: The Mystery of the Ordinary, 1926-1928,'' imported...

  4. 76 FR 63701 - Culturally Significant Objects Imported for Exhibition Determinations: “Anglo-Saxon Hoard: Gold...

    Science.gov (United States)

    2011-10-13

    ... for Exhibition Determinations: ``Anglo-Saxon Hoard: Gold From England's Dark Ages'' SUMMARY: Notice is... objects to be included in the exhibition ``Anglo-Saxon Hoard: Gold From England's Dark Ages,'' imported...

  5. 77 FR 56697 - Culturally Significant Objects Imported for Exhibition Determinations: “The English Prize: The...

    Science.gov (United States)

    2012-09-13

    ... for Exhibition Determinations: ``The English Prize: The Capture of the Westmorland, an Episode of the..., 2003), I hereby determine that the objects to be included in the exhibition ``The English Prize:...

  6. 75 FR 82128 - Culturally Significant Objects Imported for Exhibition Determinations: “Vishnu: Hinduism's Blue...

    Science.gov (United States)

    2010-12-29

    ... for Exhibition Determinations: ``Vishnu: Hinduism's Blue-Skinned Savior'' SUMMARY: Notice is hereby... hereby determine that the objects to be included in the exhibition ``Vishnu: Hinduism's Blue-Skinned...

  7. Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological abnormalities

    Institute of Scientific and Technical Information of China (English)

    Hui Dong; Fu'er Lu; Nan Wang; Xin Zou; Jingjing Rao

    2011-01-01

    Haemorheological abnormalities have been described in diabetes mellitus,as well as in non-alcoholic fatty liver disease (NAFLD).However,the relationship between the changes in liver fat content and haemorheology is unknown.The current study aims to show the correlation between haemorheological parameters and intrahepatic lipid content (IHLC) in patients with type 2 diabetes.The serum biochemical markers,such as fasting plasma glucose (FPG),haemoglobin A1c (HbA1c),liver enzymes,lipid profiles,and haemorheological properties,were examined.IHLC was quantified using proton magnetic resonance spectroscopy (1H-MRS) scanning of the liver.A significant correlation was observed between IHLC and whole blood viscosity at high,middle,and low shear rates.IHLC also positively correlated with haematocrit,the reduced whole blood viscosity at low and middle shear rates,and the erythrocyte aggregation index.Diabetic patients with NAFLD exhibited significant haemorheological abnormalities compared with patients without NAFLD.In summary,haemorheological disorders are linked to non-alcoholic fatty liver in type 2 diabetes.

  8. A Nanotube Surface Reinforced Graphite Fiber Exhibiting Significantly Enhanced Properties Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Nanotechnology which includes carbon nanotubes has the potential to produce materials that exhibit properties beyond those expected from conventional materials which...

  9. 78 FR 43960 - Culturally Significant Objects Imported for Exhibition Determinations: “Dante Ferretti: Design...

    Science.gov (United States)

    2013-07-22

    ... Construction for Cinema'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... ``Dante Ferretti: Design and Construction for Cinema,'' imported from abroad for temporary exhibition...

  10. 77 FR 51606 - Culturally Significant Objects Imported for Exhibition Determinations: “Extravagant Inventions...

    Science.gov (United States)

    2012-08-24

    ... Furniture of the Roentgens,'' Formerly Titled ``Seductive Luxury and Innovation: The Furniture of Abraham... State pertaining to the exhibition ``Seductive Luxury and Innovation: The Furniture of Abraham and David... additional exhibit objects at The Metropolitan Museum of Art, New York, NY, from on or about October 29,...

  11. 76 FR 35068 - Culturally Significant Objects Imported for Exhibition Determinations; “Monet/Lichtenstein: Rouen...

    Science.gov (United States)

    2011-06-15

    .../Lichtenstein: Rouen Cathedrals,'' imported from abroad for temporary exhibition within the United States, are... of Fine Arts, Boston, Boston, Massachusetts, from on or about July 3, 2011, until on or...

  12. 77 FR 53248 - Culturally Significant Objects Imported for Exhibition Determinations: “Swiss Treasures: From...

    Science.gov (United States)

    2012-08-31

    ... Papyrus and Parchment to Erasmus, Zwingli, Calvin, and Barth'' SUMMARY: Notice is hereby given of the... exhibition ``Swiss Treasures: From Biblical Papyrus and Parchment to Erasmus, Zwingli, Calvin, and...

  13. 78 FR 51803 - Culturally Significant Objects Imported for Exhibition Determinations: “Vasily Kandinsky: From...

    Science.gov (United States)

    2013-08-21

    ... to the Bauhaus, 1910-1925'' SUMMARY: Notice is hereby given of the following determinations: Pursuant...: From Blaue Reiter to the Bauhaus, 1910-1925,'' imported from abroad for temporary exhibition within...

  14. Ocimum basilicum extract exhibits antidiabetic effects via inhibition of hepatic glucose mobilization and carbohydrate metabolizing enzymes

    Science.gov (United States)

    Ezeani, Chinelo; Ezenyi, Ifeoma; Okoye, Theophine; Okoli, Charles

    2017-01-01

    Aim: Ocimum basilicum L (Lamiaceae) is used as a traditional remedy for different ailments, including diabetes mellitus. This study investigated the antidiabetic effects of an extract of aerial parts of O. basilicum. Methods: Antihyperglycemic effect of the extract was determined by its effects on α-amylase and α-glucosidase in vitro, while antidiabetic properties were studied in alloxan induced diabetic rats treated for 28 days with extract and compared to those treated with oral metformin (150 mg/kg). The study and analysis was conducted between 2014 and 2015. Results: The treatment with 100 and 200 mg/kg extract significantly (P glycogenolysis and/or stimulate glycogenesis. PMID:28163956

  15. Lippia alba morphotypes cidreira and melissa exhibit significant differences in leaf characteristics and essential oil profile

    Directory of Open Access Journals (Sweden)

    Caroline N. Jezler

    2013-04-01

    Full Text Available Lippia alba (Mill. N.E. Br. ex Britton & P. Wilson, Verbenaceae, is widely used in traditional Brazilian medicine for the treatment of abdominal distress. The species exhibits considerable chemical and morphological diversity, and various chemotypes have been characterized. A comparative study of L. alba, has been carried out of the morphoanatomical characteristics of the leaves and the profiles of the essential oils of the morphotypes cidreira and melissa grown in the Medicinal Plant Garden of the Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazil. The mean plant height of cidreira was 1.80 m and the stems and branches were fairly erect, while melissa plants were smaller (1.60 m and presented prostrate stems and branches. Although the leaf of the morphotypes look were similar, the mean values of length, width and area of the leaves of cidreira (respectively, 7.42 cm, 3.32 cm and 17.31 cm² differed significantly from those of melissa (4.68 cm, 2.35 cm and 7.32 cm2. The morphotypes presented amphistomatic leaves with uniseriate epidermis on both surfaces. The mesophyll was dorsiventral, but in cidreira the palisade parenchyma was biseriate while in melissa it was uniseriate. Simple tector and capitate glandular trichomes were present on the adaxial and abaxial surfaces of the leaf blades of both morphotypes. Six distinct types of glandular trichomes could be distinguished: types I and II were present in both morphotypes, while type III was detected only in cidreira, and types IV to VI were present only in melissa. The two morphotypes also differed with respect to the composition of the essential oil, cidreira produced oil composed mainly of citral, while the oil from melissa was rich in citral, limonene and carvone.

  16. Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions

    Directory of Open Access Journals (Sweden)

    Morgan Claire C

    2012-07-01

    Full Text Available Abstract Background Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY of independent evolution between these species. For a given set of human disease related genes, it is therefore important to determine if functional equivalency has been retained between species. In this study we test the hypothesis that cancer associated genes have different patterns of substitution akin to adaptive evolution in different mammal lineages. Results Our analysis of the current literature and colon cancer databases identified 22 genes exhibiting colon cancer associated germline mutations. We identified orthologs for these 22 genes across a set of high coverage (>6X vertebrate genomes. Analysis of these orthologous datasets revealed significant levels of positive selection. Evidence of lineage-specific positive selection was identified in 14 genes in both ancestral and extant lineages. Lineage-specific positive selection was detected in the ancestral Euarchontoglires and Hominidae lineages for STK11, in the ancestral primate lineage for CDH1, in the ancestral Murinae lineage for both SDHC and MSH6 genes and the ancestral Muridae lineage for TSC1. Conclusion Identifying positive selection in the Primate, Hominidae, Muridae and Murinae lineages suggests an ancestral functional shift in these genes between the rodent and primate lineages. Analyses such as this, combining evolutionary theory and predictions - along with medically relevant data, can thus provide us with important clues for modeling human diseases.

  17. Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions

    Science.gov (United States)

    2012-01-01

    Background Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our assumptions of functional equivalence fail to consider the opportunity for divergence conferred by ~180 Million Years (MY) of independent evolution between these species. For a given set of human disease related genes, it is therefore important to determine if functional equivalency has been retained between species. In this study we test the hypothesis that cancer associated genes have different patterns of substitution akin to adaptive evolution in different mammal lineages. Results Our analysis of the current literature and colon cancer databases identified 22 genes exhibiting colon cancer associated germline mutations. We identified orthologs for these 22 genes across a set of high coverage (>6X) vertebrate genomes. Analysis of these orthologous datasets revealed significant levels of positive selection. Evidence of lineage-specific positive selection was identified in 14 genes in both ancestral and extant lineages. Lineage-specific positive selection was detected in the ancestral Euarchontoglires and Hominidae lineages for STK11, in the ancestral primate lineage for CDH1, in the ancestral Murinae lineage for both SDHC and MSH6 genes and the ancestral Muridae lineage for TSC1. Conclusion Identifying positive selection in the Primate, Hominidae, Muridae and Murinae lineages suggests an ancestral functional shift in these genes between the rodent and primate lineages. Analyses such as this, combining evolutionary theory and predictions - along with medically relevant data, can thus provide us with important clues for modeling human diseases. PMID:22788692

  18. Hawthorn (Crataegus monogyna Jacq.) extract exhibits atropine-sensitive activity in a cultured cardiomyocyte assay.

    Science.gov (United States)

    Salehi, Satin; Long, Shannon R; Proteau, Philip J; Filtz, Theresa M

    2009-01-01

    Hawthorn (Crataegus spp.) plant extract is used as a herbal alternative medicine for the prevention and treatment of various cardiovascular diseases. Recently, it was shown that hawthorn extract preparations caused negative chronotropic effects in a cultured neonatal murine cardiomyocyte assay, independent of beta-adrenergic receptor blockade. The aim of this study was to further characterize the effect of hawthorn extract to decrease the contraction rate of cultured cardiomyocytes. To test the hypothesis that hawthorn is acting via muscarinic receptors, the effect of hawthorn extract on atrial versus ventricular cardiomyocytes in culture was evaluated. As would be expected for activation of muscarinic receptors, hawthorn extract had a greater effect in atrial cells. Atrial and/or ventricular cardiomyocytes were then treated with hawthorn extract in the presence of atropine or himbacine. Changes in the contraction rate of cultured cardiomyocytes revealed that both muscarinic antagonists significantly attenuated the negative chronotropic activity of hawthorn extract. Using quinuclidinyl benzilate, L-[benzylic-4,4'-(3)H] ([(3)H]-QNB) as a radioligand antagonist, the effect of a partially purified hawthorn extract fraction to inhibit muscarinic receptor binding was quantified. Hawthorn extract fraction 3 dose-dependently inhibited [(3)H]-QNB binding to mouse heart membranes. Taken together, these findings suggest that decreased contraction frequency by hawthorn extracts in neonatal murine cardiomyocytes may be mediated via muscarinic receptor activation.

  19. 75 FR 71787 - Culturally Significant Objects Imported for Exhibition Determinations: “Salvator Rosa: Bandits...

    Science.gov (United States)

    2010-11-24

    ... and Magic'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the authority... ``Salvator Rosa: Bandits, Wilderness and Magic'', imported from abroad for temporary exhibition within the... objects at the Kimbell Art Museum, Fort Worth, TX, from on or about December 12, 2010, until on or...

  20. 75 FR 21385 - Culturally Significant Objects Imported for Exhibition Determinations: “Cleopatra: The Search for...

    Science.gov (United States)

    2010-04-23

    ... Queen of Egypt'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... Queen of Egypt,'' imported from abroad for temporary exhibition within the United States, are of... of Art, Fort Lauderdale, FL, from on or about January 1, 2013, until on or about May 31, 2013; and...

  1. 76 FR 1660 - Culturally Significant Objects Imported for Exhibition Determinations: “Reconfiguring an African...

    Science.gov (United States)

    2011-01-11

    ... to the Mask by Modern and Contemporary Artists From Three Continents'' SUMMARY: Notice is hereby... to the Mask by Modern and Contemporary Artists from Three Continents,'' imported from abroad for... display of the exhibit objects at the Metropolitan Museum of Art, New York, NY, from on or about March 8...

  2. Garlic extract exhibits antiamyloidogenic activity on amyloid-beta fibrillogenesis: relevance to Alzheimer's disease.

    Science.gov (United States)

    Gupta, Veer Bala; Indi, S S; Rao, K S J

    2009-01-01

    Alzheimer's disease is characterized pathologically by the deposition of amyloid plaques. Fibrillar Abeta is the principal component of amyloid plaques in the brain of AD patients. The prevention of Abeta aggregation or dissolution of fibrillar Abeta has clinical significance. The present communication examined in vitro the antiamyloidogenic properties of garlic extract. The effects of aqueous garlic extract (both fresh and boiled) on Abeta aggregation and defibrillation were studied by thioflavin-T based fluorescence assay, transmission electron microscopy and SDS-polyacrylamide gel electrophoresis. The aqueous fresh garlic extract not only inhibited Abeta fibril formation in a concentration and time dependent manner but was also able to defibrillate Abeta preformed fibrils. The maximum defibrillization was observed after 2-3 days of incubation. The boiled aqueous garlic extract also retained its antiamyloidogenic activity. This indicated that antiamyloidogenic activity of garlic extract is non-enzymatic, i.e. proteases present in garlic did not degrade Abeta in solution. However, the fibril degrading ability of boiled garlic extract was significantly lost. The findings suggest that consumption of garlic may lead to inhibition of Abeta aggregation in human brain.

  3. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Finding of No Significant Environmental Impact I... Environmental Impact SUBJECT: Finding of No Significant Environmental Impact and Necessary Environmental... human environment. Therefore, the preparation of an environmental impact statement is not necessary. I...

  4. Electrochemical approaches employed for sensing the antioxidant capacity exhibited by vegetal extracts: a review.

    Science.gov (United States)

    Hilgemann, Maurício; Bassetto, Victor Costa; Kubota, Lauro Tatsuo

    2013-02-01

    Vegetal extracts are among the most important source of polyphenols in the diet, highlighting the importance of their characterization and determination. For this reason, analytical methods have gained increasing interest, with many publications devoted to this subject. Among the wide possibilities of analytical methods, electroanalytical techniques can provide valuable information, since the antioxidant activity of polyphenols is related to their electrochemical properties. This review analyzes and highlights the role of electroanalytical approaches for sensing the antioxidant capacity exhibited by vegetal extracts, as well as focuses on their importance for human health. The analytical capacity of the electrochemistry is comprehensively stated with the selected results found in the literature, mainly from 2000 up to the present date.

  5. Greek plant extracts exhibit selective estrogen receptor modulator (SERM)-like properties.

    Science.gov (United States)

    Kassi, Eva; Papoutsi, Zoi; Fokialakis, Nikolaos; Messari, Ioanna; Mitakou, Sophia; Moutsatsou, Paraskevi

    2004-11-17

    To prevent bone loss that occurs with increasing age, nutritional and pharmacological factors are needed. Traditional therapeutic agents (selective estrogen receptor modulators or SERMs, biphosphonates, calcitonin) may have serious side effects or contraindications. In an attempt to find food components potentially acting as SERMs, we submitted four plant aqueous extracts derived from Greek flora (Sideritis euboea, Sideritis clandestina, Marticaria chamomilla, and Pimpinella anisum) in a series of in vitro biological assays reflective of SERM profile. We examined their ability (a) to stimulate the differentiation and mineralization of osteoblastic cell culture by histochemical staining for alkaline phosphatase and Alizarin Red-S staining, (b) to induce, like antiestrogens, the insulin growth factor binding protein 3 (IGFBP3) in MCF-7 breast cancer cells, and (c) to proliferate cervical adenocarcinoma (HeLa) cells by use of MTT assay. Our data reveal that all the plant extracts studied at a concentration range 10-100 microg/mL stimulate osteoblastic cell differentiation and exhibit antiestrogenic effect on breast cancer cells without proliferative effects on cervical adenocarcinoma cells. The presence of estradiol inhibited the antiestrogenic effect induced by the extracts on MCF-7 cells, suggesting an estrogen receptor-related mechanism. In conclusion, the aqueous extracts derived from Sideritis euboea, Sideritis clandestina, Marticaria chamomilla, and Pimpinella anisum may form the basis to design "functional foods" for the prevention of osteoporosis.

  6. 76 FR 45646 - Culturally Significant Objects Imported for Exhibition Determinations: “5,000 Years of Chinese...

    Science.gov (United States)

    2011-07-29

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``5,000 Years of Chinese Jade..., 2003), I hereby determine that the objects to be included in the exhibition ``5,000 Years of...

  7. 78 FR 77771 - Culturally Significant Object Imported for Exhibition Determinations: “Love and Play: A Pair of...

    Science.gov (United States)

    2013-12-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Love and Play: A Pair of Paintings by..., I hereby determine that the object to be included in the exhibition ``Love and Play: A Pair...

  8. 75 FR 6249 - Culturally Significant Objects Imported for Exhibition Determinations: “Fiery Pool: The Maya and...

    Science.gov (United States)

    2010-02-08

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Fiery Pool: The Maya and the Mythic... hereby determine that the objects to be included in the exhibition ``Fiery Pool: The Maya and the...

  9. 77 FR 25226 - Culturally Significant Object Imported for Exhibition Determinations: “The Wealth of a Nation...

    Science.gov (United States)

    2012-04-27

    ... Culturally Significant Object Imported for Exhibition Determinations: ``The Wealth of a Nation: British... April 15, 2003), I hereby determine that the object to be included in the exhibition ``The Wealth of a Nation: British Silver from the Museum's Collection,'' imported from abroad for temporary...

  10. 75 FR 13805 - Culturally Significant Objects Imported for Exhibition Determinations: “Race to the End of the...

    Science.gov (United States)

    2010-03-23

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Race to the End of the Earth..., the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note... that the objects to be included in the exhibition ``Race to the End of the Earth,'' imported from...

  11. 76 FR 51458 - Culturally Significant Objects Imported for Exhibition Determinations: “Wonder of the Age: Master...

    Science.gov (United States)

    2011-08-18

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Wonder of the Age: Master Painters... Age: Master Painters of India, 1100-1900,'' imported from abroad for temporary exhibition within...

  12. 75 FR 28095 - Culturally Significant Object Imported for Exhibition Determinations: “E Ku Ana Ka Paia...

    Science.gov (United States)

    2010-05-19

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``E Ku Ana Ka Paia: Unification... 15, 2003 , I hereby determine that the object to be included in the exhibition ``E Ku Ana Ka...

  13. 77 FR 64373 - Culturally Significant Object Imported for Exhibition Determinations: “Erotic Gold: The Art and...

    Science.gov (United States)

    2012-10-19

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Object Imported for Exhibition Determinations: ``Erotic Gold: The Art and Life of... April 15, 2003), I hereby determine that the object to be included in the exhibition ``Erotic Gold: The...

  14. 75 FR 41274 - Culturally Significant Objects Imported for Exhibition Determinations: “The Art of Ancient Greek...

    Science.gov (United States)

    2010-07-15

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Art of Ancient Greek Theater... Ancient Greek Theater,'' imported from abroad for temporary exhibition within the United States, are of...

  15. 76 FR 73759 - Culturally Significant Objects Imported for Exhibition Determinations: “Ancient Egypt-Art and...

    Science.gov (United States)

    2011-11-29

    ... Culturally Significant Objects Imported for Exhibition Determinations: ``Ancient Egypt--Art and Magic: Treasures From the Foundation Gandur pour L'Art, Geneva, Switzerland'' SUMMARY: Notice is hereby given of... included in the exhibition ``Ancient Egypt--Art and Magic: Treasures from the Foundation Gandur pour...

  16. 75 FR 38589 - Culturally Significant Objects Imported for Exhibition Determinations: “The Origins of Writing in...

    Science.gov (United States)

    2010-07-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``The Origins of Writing in the... hereby determine that the objects to be included in the exhibition ``The Origins of Writing in...

  17. 78 FR 58378 - Culturally Significant Objects Imported for Exhibition Determinations: “Peru: Kingdoms of the Sun...

    Science.gov (United States)

    2013-09-23

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Peru: Kingdoms of the Sun and the..., 2003), I hereby determine that the objects to be included in the exhibition ``Peru: Kingdoms of the...

  18. 78 FR 4585 - Culturally Significant Objects Imported for Exhibition Determinations: “Albrecht Dürer: Master...

    Science.gov (United States)

    2013-01-22

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Albrecht D rer: Master Drawings...: Master Drawings, Watercolors, and Prints from the Albertina,'' imported from abroad for...

  19. Single-, few-, and multilayer graphene not exhibiting significant advantages over graphite microparticles in electroanalysis.

    Science.gov (United States)

    Goh, Madeline Shuhua; Pumera, Martin

    2010-10-01

    This report compares the electroanalytical performances of single- (G-SL), few- (G-FL), and multilayer graphene (G-ML), graphite microparticles, and edge-plane pyrolytic graphite electrodes in terms of sensitivity, linearity, and repeatability. We show that in the case of differential pulse voltammetric (DPV) detection of ascorbic acid, the sensitivity of a G-SL electrode is about 30% greater than that of G-ML and about 40% greater than graphite microparticles. However, in the case of DPV determination of uric acid, sensitivity is practically the same for all (G-SL, G-FL, and G-ML) and, importantly, the graphite microparticles do provide higher sensitivity than graphenes do for this analyte. Graphenes also do not provide a significant advantage in terms of repeatability. We pose the question of whether the efforts leading to the bulk method of producing single-layer graphene are justified for electroanalytical applications.

  20. Green synthesis of silver nanoparticles using Delphinium denudatum root extract exhibits antibacterial and mosquito larvicidal activities.

    Science.gov (United States)

    Suresh, Gopal; Gunasekar, Poosali Hariharan; Kokila, Dhanasegaran; Prabhu, Durai; Dinesh, Devadoss; Ravichandran, Nagaiya; Ramesh, Balasubramanian; Koodalingam, Arunagirinathan; Vijaiyan Siva, Ganesan

    2014-06-05

    Green synthesis of silver nanoparticles (AgNPs) using aqueous root extract of Delphinium denudatum (Dd) by reduction of Ag(+) ions from silver nitrate solution has been investigated. The synthesized DdAgNPs were characterized by using UV-Vis spectroscopy, X-ray diffraction (XRD), Field emission scanning electron microscope (FESEM) and Fourier transform infrared spectroscopy (FTIR). The prepared DdAgNPs showed maximum absorbance at 416nm and particles were polydispersed in nature, spherical in shape and the size of the particle obtained was⩽85nm. The DdAgNPs exhibited antibacterial activity against Staphylococcus aureus ATCC 6538, Bacillus cereus NCIM 2106, Escherichia coli ATCC 8739 and Pseudomonas aeruginosa ATCC 9027. The DdAgNPs showed potent larvicidal activity against second instar larvae of dengue vector Aedes aegypti with a LC50 value of 9.6ppm.

  1. Green synthesis of silver nanoparticles using Delphinium denudatum root extract exhibits antibacterial and mosquito larvicidal activities

    Science.gov (United States)

    Suresh, Gopal; Gunasekar, Poosali Hariharan; Kokila, Dhanasegaran; Prabhu, Durai; Dinesh, Devadoss; Ravichandran, Nagaiya; Ramesh, Balasubramanian; Koodalingam, Arunagirinathan; Vijaiyan Siva, Ganesan

    2014-06-01

    Green synthesis of silver nanoparticles (AgNPs) using aqueous root extract of Delphinium denudatum (Dd) by reduction of Ag+ ions from silver nitrate solution has been investigated. The synthesized DdAgNPs were characterized by using UV-Vis spectroscopy, X-ray diffraction (XRD), Field emission scanning electron microscope (FESEM) and Fourier transform infrared spectroscopy (FTIR). The prepared DdAgNPs showed maximum absorbance at 416 nm and particles were polydispersed in nature, spherical in shape and the size of the particle obtained was ⩽85 nm. The DdAgNPs exhibited antibacterial activity against Staphylococcus aureus ATCC 6538, Bacillus cereus NCIM 2106, Escherichia coli ATCC 8739 and Pseudomonas aeruginosa ATCC 9027. The DdAgNPs showed potent larvicidal activity against second instar larvae of dengue vector Aedes aegypti with a LC50 value of 9.6 ppm.

  2. Climate impacts of oil extraction increase significantly with oilfield age

    Science.gov (United States)

    Masnadi, Mohammad S.; Brandt, Adam R.

    2017-08-01

    Record-breaking temperatures have induced governments to implement targets for reducing future greenhouse gas (GHG) emissions. Use of oil products contributes ~35% of global GHG emissions, and the oil industry itself consumes 3-4% of global primary energy. Because oil resources are becoming increasingly heterogeneous, requiring different extraction and processing methods, GHG studies should evaluate oil sources using detailed project-specific data. Unfortunately, prior oil-sector GHG analysis has largely neglected the fact that the energy intensity of producing oil can change significantly over the life of a particular oil project. Here we use decades-long time-series data from twenty-five globally significant oil fields (>1 billion barrels ultimate recovery) to model GHG emissions from oil production as a function of time. We find that volumetric oil production declines with depletion, but this depletion is accompanied by significant growth--in some cases over tenfold--in per-MJ GHG emissions. Depletion requires increased energy expenditures in drilling, oil recovery, and oil processing. Using probabilistic simulation, we derive a relationship for estimating GHG increases over time, showing an expected doubling in average emissions over 25 years. These trends have implications for long-term emissions and climate modelling, as well as for climate policy.

  3. 77 FR 319 - Culturally Significant Objects Imported for Exhibition Determinations: “Put Your Freedom in the...

    Science.gov (United States)

    2012-01-04

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF STATE Culturally Significant Objects Imported for Exhibition Determinations: ``Put Your Freedom in the Corner, Save... of Authority No. 257 of April 15, 2003), I hereby determine that the object ``Put Your Freedom in...

  4. 75 FR 27383 - Culturally Significant Objects Imported for Exhibition Determinations: “A Gift From the Desert...

    Science.gov (United States)

    2010-05-14

    ... Desert: The Art, History and Culture of the Arabian Horse,'' imported from abroad for temporary... Culturally Significant Objects Imported for Exhibition Determinations: ``A Gift From the Desert: The Art, History and Culture of the Arabian Horse'' SUMMARY: Notice is hereby given of the following...

  5. Automatically extracting the significant aspects evaluated in game reviews

    Science.gov (United States)

    Fong, Chiok Hoong; Ng, Yen Kaow

    2017-04-01

    Understanding the criteria (or "aspects") that reviewers use to evaluate games is important to game developers and publishers, since this will give them important input on how to improve their products. Techniques for the extraction of such aspects have been studied by others, albeit not specific to the gaming industry. In this paper we demonstrate an aspect extraction and analysis system specific to computer games. The system extracts game review texts from a list of known websites and automatically extracts candidate aspects from the review text using techniques from natural language processing and sentiment analysis. It then ranks the candidate aspects using the HITS algorithm. To evaluate the correctness of the extracted aspects, we used the system to calculate an overall score for each game by aggregating its highly-rated aspects, weighted by the importance of the respective aspects. The aggregated scores resulted in a ranking of games, which we compared to a known ranking from a popular website - the rankings showed overall consistency, which suggests that the system has extracted valuable aspects from the reviews. Using the extracted aspect, our system also facilitates the analysis of a game, by evaluating how review articles have rated its performance in these extracted aspects.

  6. Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects

    Science.gov (United States)

    Arya, Rakesh Kumar; Dev, Kapil; Sharma, Chetan; Hossain, Zakir; Meena, Sanjeev; Arya, K. R.; Gayen, J. R.

    2017-01-01

    As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness. Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders. The promising medicinal value of E. alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract. In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA) in multiple cancer cell lines along with control. We have also evaluated its effect on different in vivo toxicity parameters. Here, we found that AEEA was found to be most active in most of the cancer cell lines but it significantly induced apoptosis in human breast cancer cell lines by disrupting mitochondrial membrane potential and DNA damage. Moreover, AEEA treatment inhibited migration in both MCF 7 and MDA-MB-231 cells in a dose dependent manner. Further, AEEA possesses robust in vitro antioxidant activity along with high total phenolic and flavonoid contents. In summary, our results indicate that Eclipta alba has enormous potential in complementary and alternative medicine for the treatment of cancer. PMID:28250894

  7. Epimedium koreanum Nakai Water Extract Exhibits Antiviral Activity against Porcine Epidermic Diarrhea Virus In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Won-Kyung Cho

    2012-01-01

    Full Text Available Porcine epidemic diarrhea virus (PEDV causes diarrhea of pigs age-independently and death of young piglets, resulting in economic loss of porcine industry. We have screened 333 natural oriental herbal medicines to search for new antiviral candidates against PEDV. We found that two herbal extracts, KIOM 198 and KIOM 124, contain significant anti-PED viral effect. KIOM 198 and KIOM 124 were identified as Epimedium koreanum Nakai and Lonicera japonica Thunberg, respectively. The further plaque and CPE inhibition assay in vitro showed that KIOM 198 has much stronger antiviral activity than KIOM 124. Additionally, KIOM 198 exhibited a similar extent of antiviral effect against other subtypes of Corona virus such as sm98 and TGE viruses. Cytotoxicity results showed that KIOM 198 is nontoxic on the cells and suggest that it can be delivered safely for therapy. Furthermore, when we orally administered KIOM 198 to piglets and then infected them with PEDV, the piglets did not show any disease symptoms like diarrhea and biopsy results showed clean intestine, whereas control pigs without KIOM 198 treatment exhibited PED-related severe symptoms. These results imply that KIOM 198 contains strong antiviral activity and has a potential to be developed as an antiviral phytomedicine to treat PEDV-related diseases in pigs.

  8. Activities and Prevalence of Proteobacteria Members Colonizing Echinacea purpurea Fully Account for Macrophage Activation Exhibited by Extracts of This Botanical.

    Science.gov (United States)

    Haron, Mona H; Tyler, Heather L; Pugh, Nirmal D; Moraes, Rita M; Maddox, Victor L; Jackson, Colin R; Pasco, David S

    2016-09-01

    Evidence supports the theory that bacterial communities colonizing Echinacea purpurea contribute to the innate immune enhancing activity of this botanical. Previously, we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could be accounted for by total bacterial load within the plant material. In the current study, we test the hypothesis that the type of bacteria, in addition to bacterial load, is necessary to fully account for extract activity. Bacterial community composition within commercial and freshly harvested (wild and cultivated) E. purpurea aerial samples was determined using high-throughput 16S rRNA gene pyrosequencing. Bacterial isolates representing 38 different taxa identified to be present within E. purpurea were acquired, and the activity exhibited by the extracts of these isolates varied by over 8000-fold. Members of the Proteobacteria exhibited the highest potency for in vitro macrophage activation and were the most predominant taxa. Furthermore, the mean activity exhibited by the Echinacea extracts could be solely accounted for by the activities and prevalence of Proteobacteria members comprising the plant-associated bacterial community. The efficacy of E. purpurea material for use against respiratory infections may be determined by the Proteobacterial community composition of this plant, since ingestion of bacteria (probiotics) is reported to have a protective effect against this health condition. Georg Thieme Verlag KG Stuttgart · New York.

  9. Kaempferia parviflora Extract Exhibits Anti-cancer Activity against HeLa Cervical Cancer Cells

    National Research Council Canada - National Science Library

    Saranyapin Potikanond; Siriwoot Sookkhee; Mingkwan Na Takuathung; Pitchaya Mungkornasawakul; Nitwara Wikan; Duncan R. Smith; Wutigri Nimlamool

    2017-01-01

    Kaempferia parviflora (KP) has been traditionally used as a folk remedy to treat several diseases including cancer, and several studies have reported cytotoxic activities of extracts of KP against a number of different cancer cell lines...

  10. 75 FR 53730 - Culturally Significant Objects Imported for Exhibition Determinations: “Richard Hawkins-Third Mind”

    Science.gov (United States)

    2010-09-01

    ... Imported for Exhibition Determinations: ``Richard Hawkins--Third Mind'' SUMMARY: Notice is hereby given of... determine that the objects to be included in the exhibition ``Richard Hawkins--Third Mind,'' imported...

  11. 75 FR 53013 - Culturally Significant Objects Imported for Exhibition Determinations: “The Pre-Raphaelite Lens...

    Science.gov (United States)

    2010-08-30

    ... Photography and Painting, 1848-1875'' SUMMARY: Notice is hereby given of the following determinations... the exhibition ``The Pre-Raphaelite Lens: British Photography and Painting, 1848-1875,'' imported from... exhibition or display of the exhibit objects at the National Gallery of Art, Washington, DC, from on or...

  12. Compounds from Terminalia mantaly L. (Combretaceae Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance

    Directory of Open Access Journals (Sweden)

    Marthe Aimée Tchuente Tchuenmogne

    2017-01-01

    Full Text Available Background: Pathogenic yeasts resistance to current drugs emphasizes the need for new, safe, and cost-effective drugs. Also, new inhibitors are needed to control the effects of enzymes that are implicated in metabolic dysfunctions such as cancer, obesity, and epilepsy. Methods: The anti-yeast extract from Terminalia mantaly (Combretaceae was fractionated and the structures of the isolated compounds established by means of spectroscopic analysis and comparison with literature data. Activity was assessed against Candida albicans, C. parapsilosis and C. krusei using the microdilution method, and against four enzymes of metabolic significance: glucose-6-phosphate dehydrogenase, human erythrocyte carbonic anhydrase I and II, and glutathione S-transferase. Results: Seven compounds, 3,3′-di-O-methylellagic acid 4′-O-α-rhamnopyranoside; 3-O-methylellagic acid; arjungenin or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid; arjunglucoside or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid glucopyranoside; 2α,3α,24-trihydroxyolean-11,13(18-dien-28-oïc acid; stigmasterol; and stigmasterol 3-O-β-d-glucopyranoside were isolated from the extract. Among those, 3,3′-di-O-methylellagic acid 4′-O-α-rhamnopyranoside, 3-O-methylellagic acid, and arjunglucoside showed anti-yeast activity comparable to that of reference fluconazole with minimal inhibitory concentrations (MIC below 32 µg/mL. Besides, Arjunglucoside potently inhibited the tested enzymes with 50% inhibitory concentrations (IC50 below 4 µM and inhibitory constant (Ki <3 µM. Conclusions: The results achieved indicate that further SAR studies will likely identify potent hit derivatives that should subsequently enter the drug development pipeline.

  13. Kaempferia parviflora Extract Exhibits Anti-cancer Activity against HeLa Cervical Cancer Cells

    Directory of Open Access Journals (Sweden)

    Saranyapin Potikanond

    2017-09-01

    Full Text Available Kaempferia parviflora (KP has been traditionally used as a folk remedy to treat several diseases including cancer, and several studies have reported cytotoxic activities of extracts of KP against a number of different cancer cell lines. However, many aspects of the molecular mechanism of action of KP remain unclear. In particular, the ability of KP to regulate cancer cell growth and survival signaling is still largely unexplored. The current study aimed to investigate the effects of KP on cell viability, cell migration, cell invasion, cell apoptosis, and on signaling pathways related to growth and survival of cervical cancer cells, HeLa. We discovered that KP reduced HeLa cell viability in a concentration-dependent manner. The potent cytotoxicity of KP against HeLa cells was associated with a dose-dependent induction of apoptotic cell death as determined by flow cytometry and observation of nuclear fragmentation. Moreover, KP-induced cell apoptosis was likely to be mediated through the intrinsic apoptosis pathway since caspase 9 and caspase 7, but not BID, were shown to be activated after KP exposure. Based on the observation that KP induced apoptosis in HeLa cell, we further investigated the effects of KP at non-cytotoxic concentrations on suppressing signal transduction pathways relevant to cell growth and survival. We found that KP suppressed the MAPK and PI3K/AKT signaling pathways in cells activated with EGF, as observed by a significant decrease in phosphorylation of ERK1/2, Elk1, PI3K, and AKT. The data suggest that KP interferes with the growth and survival of HeLa cells. Consistent with the inhibitory effect on EGF-stimulated signaling, KP potently suppressed the migration of HeLa cells. Concomitantly, KP was demonstrated to markedly inhibit HeLa cell invasion. The ability of KP in suppressing the migration and invasion of HeLa cells was associated with the suppression of matrix metalloproteinase-2 production. These data strongly

  14. Kaempferia parviflora Extract Exhibits Anti-cancer Activity against HeLa Cervical Cancer Cells.

    Science.gov (United States)

    Potikanond, Saranyapin; Sookkhee, Siriwoot; Na Takuathung, Mingkwan; Mungkornasawakul, Pitchaya; Wikan, Nitwara; Smith, Duncan R; Nimlamool, Wutigri

    2017-01-01

    Kaempferia parviflora (KP) has been traditionally used as a folk remedy to treat several diseases including cancer, and several studies have reported cytotoxic activities of extracts of KP against a number of different cancer cell lines. However, many aspects of the molecular mechanism of action of KP remain unclear. In particular, the ability of KP to regulate cancer cell growth and survival signaling is still largely unexplored. The current study aimed to investigate the effects of KP on cell viability, cell migration, cell invasion, cell apoptosis, and on signaling pathways related to growth and survival of cervical cancer cells, HeLa. We discovered that KP reduced HeLa cell viability in a concentration-dependent manner. The potent cytotoxicity of KP against HeLa cells was associated with a dose-dependent induction of apoptotic cell death as determined by flow cytometry and observation of nuclear fragmentation. Moreover, KP-induced cell apoptosis was likely to be mediated through the intrinsic apoptosis pathway since caspase 9 and caspase 7, but not BID, were shown to be activated after KP exposure. Based on the observation that KP induced apoptosis in HeLa cell, we further investigated the effects of KP at non-cytotoxic concentrations on suppressing signal transduction pathways relevant to cell growth and survival. We found that KP suppressed the MAPK and PI3K/AKT signaling pathways in cells activated with EGF, as observed by a significant decrease in phosphorylation of ERK1/2, Elk1, PI3K, and AKT. The data suggest that KP interferes with the growth and survival of HeLa cells. Consistent with the inhibitory effect on EGF-stimulated signaling, KP potently suppressed the migration of HeLa cells. Concomitantly, KP was demonstrated to markedly inhibit HeLa cell invasion. The ability of KP in suppressing the migration and invasion of HeLa cells was associated with the suppression of matrix metalloproteinase-2 production. These data strongly suggest that KP may slow

  15. Cinnamon extract exhibits insulin-like and independent effects on gene expression in adipocytes

    Science.gov (United States)

    Cinnamon is beneficial to people with insulin resistance due in part to the insulin-like activity of the cinnamon extract (CE). Molecular effects of CE are limited. This study tested the hypothesis that CE has insulin-like and insulin-independent effects at the molecular level. Quantitative real-tim...

  16. Stroke Survivors Scoring Zero on the NIH Stroke Scale Score Still Exhibit Significant Motor Impairment and Functional Limitation

    Directory of Open Access Journals (Sweden)

    Brittany Hand

    2014-01-01

    Full Text Available Objective. To determine the National Institutes of Health Stroke Scale’s (NIHSS’s association with upper extremity (UE impairment and functional outcomes. Design. Secondary, retrospective analysis of randomized controlled trial data. Setting. Not applicable. Participants. 146 subjects with stable, chronic stroke-induced hemiparesis. Intervention. The NIHSS, the UE Fugl-Meyer (FM, and the Arm Motor Ability Test (AMAT were administered prior to their participation in a multicenter randomized controlled trial. Main Outcome Measures. The NIHSS, FM, and AMAT. Results. The association between the NIHSS and UE impairment was statistically significant (P=-0.204;p=0.014 but explained less than 4% of the variance among UE FM scores. The association between NIHSS total score and function as measured by the AMAT was not statistically significant (P=-0.141;p=0.089. Subjects scoring a “zero” on the NIHSS exhibited discernible UE motor deficits and varied scores on the UE FM and AMAT. Conclusion. While being used in stroke trials, the NIHSS may have limited ability to discriminate between treatment responses, even when only a relatively narrow array of impairment levels exists among patients. Given these findings, NIHSS use should be restricted to acute stroke studies and clinical settings with the goal of reporting stroke severity.

  17. 77 FR 75253 - Culturally Significant Objects Imported for Exhibition Determinations: “Wait, Later This Will Be...

    Science.gov (United States)

    2012-12-19

    ...: Editions by Dieter Roth'' SUMMARY: Notice is hereby given of the following determinations: Pursuant to the... Nothing: Editions by Dieter Roth,'' imported from abroad for temporary exhibition within the United...

  18. The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV).

    Science.gov (United States)

    Micol, Vicente; Caturla, Nuria; Pérez-Fons, Laura; Más, Vicente; Pérez, Luis; Estepa, Amparo

    2005-06-01

    A commercial plant extract derived from olive tree leaf (Olea europaea) (LExt) and its major compound, oleuropein (Ole), inhibited the in vitro infectivity of the viral haemorrhagic septicaemia virus (VHSV), a salmonid rhabdovirus. Incubation of virus with LExt or Ole before infection reduced the viral infectivity to 10 and 30%, respectively. Furthermore, LExt drastically decreased VHSV titers and viral protein accumulation (virucidal effect) in a dose dependent manner when added to cell monolayers 36 h post-infection. On the other hand, both the LExt and Ole were able to inhibit cell-to-cell membrane fusion induced by VHSV in uninfected cells, suggesting interactions with viral envelope. Therefore, we propose that O. europaea could be used as a potential source of promising natural antivirals, which have demonstrated to lack impact on health and environment. In addition, Ole could be used to design other related antiviral agents.

  19. In vitro antibacterial evaluation of Anabaena sp. against several clinically significant microflora and HPTLC analysis of its active crude extracts

    Directory of Open Access Journals (Sweden)

    Chauhan Abhishek

    2010-01-01

    Full Text Available The present study was conducted to evaluate the possible antibacterial activity of Anabaena extracts. Anabaena was isolated from a natural source and cultured in vitro. after suitable growth, cyanobacterial culture was harvested using different solvents. Extracts, thus prepared, were evaluated for their antibacterial potential by agar-well diffusion assay against bacterial species of clinical significance. MIC values were determined further to check the concentration ranges for significant inhibition. HPTLC analysis was done to separate the components of active crude extract in an attempt to identify the bio-active chemical entity. Methanol extract exhibited more potent activity than that of hexane and ethyl acetate extracts. No inhibitory effect was found against Pseudomonas aeruginosa, Salmonella typhi, and Klebsiella pneumoniae. Staphylococcus aureus required about 256 μg/ml of the crude methanol extract for effective inhibition. HPTLC evaluation at λ 254 nm was performed for the separation of a complex mixture of the methanol extract. The results provide evidence that Anabaena sp. extracts might indeed be potential sources of new antibacterial agents.

  20. Saraca indica Bark Extract Shows In Vitro Antioxidant, Antibreast Cancer Activity and Does Not Exhibit Toxicological Effects

    Directory of Open Access Journals (Sweden)

    Navneet Kumar Yadav

    2015-01-01

    Full Text Available Medicinal plants are used as a complementary and alternative medicine in treatment of various diseases including cancer worldwide, because of their ease of accessibility and cost effectiveness. Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability. Saraca indica (family Caesalpiniaceae is one of the most ancient sacred plants with medicinal properties, exhibiting a number of pharmacological effects. Antioxidant, antibreast cancer activity and toxicological evaluation of Saraca indica bark extract (SIE were carried out in the present study. The results of the study indicated that this herbal preparation has antioxidant and antibreast cancer activity. Toxicological studies suggest that SIE is safer to use and may have a potential to be used as complementary and alternative medicine for breast cancer therapy.

  1. Traditional Preparations and Methanol Extracts of Medicinal Plants from Papua New Guinea Exhibit Similar Cytochrome P450 Inhibition

    Directory of Open Access Journals (Sweden)

    Erica C. Larson

    2016-01-01

    Full Text Available The hypothesis underlying this current work is that fresh juice expressed from Papua New Guinea (PNG medicinal plants (succus will inhibit human Cytochrome P450s (CYPs. The CYP inhibitory activity identified in fresh material was compared with inhibition in methanol extracts of dried material. Succus is the most common method of traditional medicine (TM preparation for consumption in PNG. There is increasing concern that TMs might antagonize or complicate drug therapy. We have previously shown that methanol extracts of commonly consumed PNG medicinal plants are able to induce and/or inhibit human CYPs in vitro. In this current work plant succus was prepared from fresh plant leaves. Inhibition of three major CYPs was determined using human liver microsomes and enzyme-selective model substrates. Of 15 species tested, succus from 6/15 was found to inhibit CYP1A2, 7/15 inhibited CYP3A4, and 4/15 inhibited CYP2D6. Chi-squared tests determined differences in inhibitory activity between succus and methanol preparations. Over 80% agreement was found. Thus, fresh juice from PNG medicinal plants does exhibit the potential to complicate drug therapy in at risk populations. Further, the general reproducibility of these findings suggests that methanol extraction of dried material is a reasonable surrogate preparation method for fresh plant samples.

  2. Marine organism sulfated polysaccharides exhibiting significant antimalarial activity and inhibition of red blood cell invasion by Plasmodium.

    Science.gov (United States)

    Marques, Joana; Vilanova, Eduardo; Mourão, Paulo A S; Fernàndez-Busquets, Xavier

    2016-04-13

    The antimalarial activity of heparin, against which there are no resistances known, has not been therapeutically exploited due to its potent anticoagulating activity. Here, we have explored the antiplasmodial capacity of heparin-like sulfated polysaccharides from the sea cucumbers Ludwigothurea grisea and Isostichopus badionotus, from the red alga Botryocladia occidentalis, and from the marine sponge Desmapsamma anchorata. In vitro experiments demonstrated for most compounds significant inhibition of Plasmodium falciparum growth at low-anticoagulant concentrations. This activity was found to operate through inhibition of erythrocyte invasion by Plasmodium, likely mediated by a coating of the parasite similar to that observed for heparin. In vivo four-day suppressive tests showed that several of the sulfated polysaccharides improved the survival of Plasmodium yoelii-infected mice. In one animal treated with I. badionotus fucan parasitemia was reduced from 10.4% to undetectable levels, and Western blot analysis revealed the presence of antibodies against P. yoelii antigens in its plasma. The retarded invasion mediated by sulfated polysaccharides, and the ensuing prolonged exposure of Plasmodium to the immune system, can be explored for the design of new therapeutic approaches against malaria where heparin-related polysaccharides of low anticoagulating activity could play a dual role as drugs and as potentiators of immune responses.

  3. Marine organism sulfated polysaccharides exhibiting significant antimalarial activity and inhibition of red blood cell invasion by Plasmodium

    Science.gov (United States)

    Marques, Joana; Vilanova, Eduardo; Mourão, Paulo A. S.; Fernàndez-Busquets, Xavier

    2016-01-01

    The antimalarial activity of heparin, against which there are no resistances known, has not been therapeutically exploited due to its potent anticoagulating activity. Here, we have explored the antiplasmodial capacity of heparin-like sulfated polysaccharides from the sea cucumbers Ludwigothurea grisea and Isostichopus badionotus, from the red alga Botryocladia occidentalis, and from the marine sponge Desmapsamma anchorata. In vitro experiments demonstrated for most compounds significant inhibition of Plasmodium falciparum growth at low-anticoagulant concentrations. This activity was found to operate through inhibition of erythrocyte invasion by Plasmodium, likely mediated by a coating of the parasite similar to that observed for heparin. In vivo four-day suppressive tests showed that several of the sulfated polysaccharides improved the survival of Plasmodium yoelii-infected mice. In one animal treated with I. badionotus fucan parasitemia was reduced from 10.4% to undetectable levels, and Western blot analysis revealed the presence of antibodies against P. yoelii antigens in its plasma. The retarded invasion mediated by sulfated polysaccharides, and the ensuing prolonged exposure of Plasmodium to the immune system, can be explored for the design of new therapeutic approaches against malaria where heparin-related polysaccharides of low anticoagulating activity could play a dual role as drugs and as potentiators of immune responses. PMID:27071342

  4. Conformational Transformation Exhibited by the Peptide Extracted from Crystalline Region of Bombyx mori Silk Fibroin in Solid and Solution States

    Institute of Scientific and Technical Information of China (English)

    YAO Ju-Ming; ZHANG Guo-Qing; LEI Cai-Hong

    2006-01-01

    The conformational transformation of a 30-residue peptide H(Ala-Gly-Ser-Gly-Ala-Gly)5OH, i.e., (AGSGAG)5,extracted from highly crystalline region of Bombyx mori (B. mori) silk fibroin was described by using the high resolution solid state 13C NMR, and CD spectroscopies. Based on the conformation-dependent 13C NMR chemical shifts of the Ala, Gly and Ser residues and the line-shape analysis of the conformation sensitive Ala Cβ resonance,the peptide revealed a strong preference for silk Ⅱ structural form, i.e., an antiparallel β-sheet structure (φ=-140±20° and ψ= 135±20°) in solid state. On the contrary, the CD spectra of this peptide in the two non-native hexafluorinated fibre spinning solvents, hexafluoroisopropanol (HFIP) and hexafluoroacetone (HFA), exhibited the existence of an unusual tightly-folded conformation resembling 310-helix (φ=-60±20° and ψ=- 30 ± 20°), as judged from the R ratio of [θ]222/[θ]203 in HFIP solution, whereas a dynamically averaged unordered structure in HFA. Taken together, the information inclined to hypothesis that the primary structure of the highly crystalline regions of B. mori silk fibroin may be easily accessible to the large conformational changes, which in turn may be critical for facilitating the structural transformation from unprocessed silk fibroin (silk Ⅰ form) to processed silk fiber (silk Ⅱ form).

  5. DETECTION AND CLINICAL SIGNIFICANCE OF THROMBOMODULIN IN BOTH PLASMA AND TISSUE EXTRACTS OF CANCER PATIENTS

    Institute of Scientific and Technical Information of China (English)

    许晓华; 卢兴国; 徐根波; 朱蕾; 黄连生

    2004-01-01

    Objective: To study the changes of thrombomodulin (TM) in both plasma and tissue extracts of cancer patients for evaluating its clinical significance. Methods: Plasma TM levels were measured by enzyme-linked immunosorbent assay (ELISA) in both plasma of 188 cancer patients and 24 cancer tissue extracts including their adjacent non-cancer tissues. Results: The plasma TM levels both in cancer patients and in metastasis patients were significantly higher than that in controls [(33.47±14.25)μg/L, (41.68±16.96)μg/L, vs(20.40±7.22)μg/L,P0.05). The TM levels in cancer tissue extracts were significantly lower than that in their adjacent non-cancer tissue extracts [(647.71±317.51)μg/L vs (1455.63±772.22)μg/L, P<0.01]. On the contrary, the plasma TM levels in these cancers were significantly higher than that in controls. Conclusion: The rise of plasma TM levels in cancer patients was associated with metastasis and diffusion of cancers. The TM levels can be served as an sensitive index for judging progression and metastasis of cancers.

  6. Humic-Like Substances from Different Compost Extracts Could Significantly Promote Cucumber Growth

    Institute of Scientific and Technical Information of China (English)

    XU Da-Bing; WANG Qiu-Jun; WU Yun-Cheng; YU Guang-Hui; SHEN Qi-Rong; HUANG Qi-Wei

    2012-01-01

    The effects of direct extracts of compost (DEC),aerated fermentation extracts of compost (AFEC) and non-aerated fermentation extracts of compost (NAFEC) on cucumber growth and the action mechanisms were evaluated based on the structure and activity analysis of humic-like substances.AFEC increased cucumber growth most significantly,followed by DEC and NAFEC,which was insignificant compared to the control treatment.Humic-like substances from compost extracts played an important role in promoting cucumber growth.Application of humic-like substances stimulated auxin-like activity and increased chlorophyll content and nitrogen accumulation in plants.The positive auxin-like activity of humic-like substances could be attributed to the relative distribution of special carbon groups,such as those with a large amount of peptidic and carbohydratic groups or with a low content of phenolic groups.In conclusion,the best growth promotion by application of AFEC was mainly attributed to the humic-like substances in the AFEC.

  7. Activities and prevalence of proteobacteria members colonizing Echinacea purpurea fully account for in vitro macrophage activation exhibited by extracts of this botanical

    Science.gov (United States)

    Evidence supports the theory that bacterial communities colonizing Echinacea purpurea contribute to the innate immune enhancing activity of this botanical. Previously we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could ...

  8. An Aqueous Extract of Marine Microalgae Exhibits Antimetastatic Activity through Preferential Killing of Suspended Cancer Cells and Anticolony Forming Activity

    National Research Council Canada - National Science Library

    Somasekharan, Syam Prakash; El-Naggar, Amal; Sorensen, Poul H; Wang, Yuzhuo; Cheng, Hongwei

    2016-01-01

    .... In the present study, an aqueous extract of a Canadian marine microalgal preparation was assessed for anticancer activities using various assays and cell lines of human cancers, including lung...

  9. Stem bark extract and fraction of Persea americana (Mill.) exhibits bactericidal activities against strains of bacillus cereus associated with food poisoning.

    Science.gov (United States)

    Akinpelu, David A; Aiyegoro, Olayinka A; Akinpelu, Oluseun F; Okoh, Anthony I

    2014-12-30

    The study investigates the in vitro antibacterial potentials of stem bark extracts of Persea americana on strains of Bacillus cereus implicated in food poisoning. The crude stem bark extracts and butanolic fraction at a concentration of 25 mg/mL and 10 mg/mL, respectively, exhibited antibacterial activities against test isolates. The zones of inhibition exhibited by the crude extract and the fraction ranged between 10 mm and 26 mm, while the minimum inhibitory concentration values ranged between 0.78 and 5.00 mg/mL. The minimum bactericidal concentrations ranged between 3.12 mg/mL-12.5 mg/mL and 1.25-10 mg/mL for the extract and the fraction, respectively. The butanolic fraction killed 91.49% of the test isolates at a concentration of 2× MIC after 60 min of contact time, while a 100% killing was achieved after the test bacterial cells were exposed to the butanolic fraction at a concentration of 3× MIC after 90 min contact time. Intracellular protein and potassium ion leaked out of the test bacterial cells when exposed to certain concentrations of the fraction; this is an indication of bacterial cell wall disruptions by the extract's butanolic fraction and, thus, caused a biocidal effect on the cells, as evident in the killing rate test results.

  10. Zephycandidine A, the First Naturally Occurring Imidazo[1,2-f]phenanthridine Alkaloid from Zephyranthes candida, Exhibits Significant Anti-tumor and Anti-acetylcholinesterase Activities

    Science.gov (United States)

    Zhan, Guanqun; Qu, Xiaolan; Liu, Junjun; Tong, Qingyi; Zhou, Junfei; Sun, Bin; Yao, Guangmin

    2016-09-01

    Zephycandidine A (1), the first naturally occurring imidazo[1,2-f]phenanthridine alkaloid, was isolated from Zephyranthes candida (Amaryllidaceae). The structure of 1 was elucidated by spectroscopic analyses and NMR calculation, and a plausible biogenetic pathway for zephycandidine A (1) was proposed. Zephycandidine A (1) exhibited significant cytotoxicity against five cancer cell lines with IC50 values ranging from 1.98 to 7.03 μM with selectivity indices as high as 10 when compared to the normal Beas-2B cell. Further studies suggested that zephycandidine A (1) induces apoptosis in leukemia cells by the activation of caspase-3, upregulation of Bax, downregulation of Bcl-2, and degradation of PARP expression. In addition, zephycandidine A (1) showed acetylcholinesterase (AChE) inhibitory activity, and the docking studies of zephycandidine A (1) and galanthamine (2) with AChE revealed that interactions with W286 and Y337 are necessary.

  11. Ethanol extract of Artemisia sieversiana exhibits anticancer effects and induces apoptosis through a mitochondrial pathway involving DNA damage in COLO-205 colon carcinoma cells

    Directory of Open Access Journals (Sweden)

    Jun Tang

    2015-08-01

    Full Text Available The aim of the study was to see the antiproliferative and apoptotic effects of ethanolic herbal extract of Artemisia sieversiana against three human colon cancer (HT-29, HCT-15 and COLO-205 cells. The cytotoxicity of the extract on these cell lines was evaluated by MTT assay. Phase contrast and fluorescence microscopy using acridine orange/ethidium bromide (AO/ETBR staining was employed to investigate morphological alterations in COLO-205 cells by the herbal extract. Flow cytometry instrument measured the changes in mitochondrial membrane potential loss while as gel electrophoresis measured DNA damage in these cells. The extract at increasing doses exhibited a strong cytotoxic effect in a dose-dependent manner against all the three colon cancer cell lines. The IC50 values of the extract against HT-29, HCT-15 and COLO-205 cancer cells were found to be 52.1, 43.2 and 38.6 µg/mL respectively. Mitochondrial membrane potential loss (ΔΨm and DNA fragmentation events were also observed following extract treatment at increasing doses.

  12. Stem Bark Extract and Fraction of Persea americana (Mill. Exhibits Bactericidal Activities against Strains of Bacillus cereus Associated with Food Poisoning

    Directory of Open Access Journals (Sweden)

    David A. Akinpelu

    2014-12-01

    Full Text Available The study investigates the in vitro antibacterial potentials of stem bark extracts of Persea americana on strains of Bacillus cereus implicated in food poisoning. The crude stem bark extracts and butanolic fraction at a concentration of 25 mg/mL and 10 mg/mL, respectively, exhibited antibacterial activities against test isolates. The zones of inhibition exhibited by the crude extract and the fraction ranged between 10 mm and 26 mm, while the minimum inhibitory concentration values ranged between 0.78 and 5.00 mg/mL. The minimum bactericidal concentrations ranged between 3.12 mg/mL–12.5 mg/mL and 1.25–10 mg/mL for the extract and the fraction, respectively. The butanolic fraction killed 91.49% of the test isolates at a concentration of 2× MIC after 60 min of contact time, while a 100% killing was achieved after the test bacterial cells were exposed to the butanolic fraction at a concentration of 3× MIC after 90 min contact time. Intracellular protein and potassium ion leaked out of the test bacterial cells when exposed to certain concentrations of the fraction; this is an indication of bacterial cell wall disruptions by the extract’s butanolic fraction and, thus, caused a biocidal effect on the cells, as evident in the killing rate test results.

  13. Kefir exhibits anti‑proliferative and pro‑apoptotic effects on colon adenocarcinoma cells with no significant effects on cell migration and invasion.

    Science.gov (United States)

    Khoury, Nathalie; El-Hayek, Stephany; Tarras, Omayr; El-Sabban, Marwan; El-Sibai, Mirvat; Rizk, Sandra

    2014-11-01

    Kefir, a fermented milk product, exhibits anti‑tumoral activity in vivo; yet its mechanism of action remains elusive. Recent studies have focused on the mechanism of action of kefir on cancer cells in vitro. The current study aims at examining the effect of kefir on cell survival, proliferation, and motility of colorectal cancer (CRC) cells. Kefir's anti‑cancer potential was tested on CRC cell lines, Caco‑2 and HT‑29, through cytotoxicity, proliferation, and apoptotic assays. The expression of certain genes involved in proliferation and apoptosis was measured using reverse transcriptase‑polymerase chain reaction (RT‑PCR) and western blotting. To assess the effect of kefir on cancer metastasis, wound‑healing and time‑lapse movies, in addition to collagen‑based invasion assay, were used. The results show that cell‑free fractions of kefir exhibit an anti‑proliferative effect on Caco‑2 and HT‑29 cells. Analysis of DNA content by flow cytometry revealed the ability of kefir to induce cell cycle arrest at the G1 phase. Kefir was also found to induce apoptosis, as seen by cell death ELISA. Results from RT‑PCR showed that kefir decreases the expression of transforming growth factor α (TGF‑α); and transforming growth factor‑β1 (TGF‑β1) in HT‑29 cells. Western blotting results revealed an upregulation in Bax:Bcl‑2 ratio, confirming the pro‑apoptotic effect of kefir, and an increase in p53 independent‑p21 expression upon kefir treatment. MMP expression was not altered by kefir treatment. Furthermore, results from time‑lapse motility movies, wound‑healing, and invasion assays showed no effect on the motility of colorectal as well as breast (MCF‑7 and MB‑MDA‑231) cancer cells upon kefir treatment. Our data suggest that kefir is able to inhibit the proliferation and induce apoptosis in HT‑29 and Caco‑2 CRC cells, yet it does not exhibit a significant effect on the motility and invasion of these cells in vitro.

  14. Water extracts of cinnamon and clove exhibits potent inhibition of protein glycation and anti-atherosclerotic activity in vitro and in vivo hypolipidemic activity in zebrafish.

    Science.gov (United States)

    Jin, Seori; Cho, Kyung-Hyun

    2011-07-01

    Advanced glycation end products contribute to the pathogenesis of diabetic complications and atherosclerosis. Aqueous extracts of ground pepper, cinnamon, rosemary, ginger, and clove were analyzed and tested for anti-atherosclerotic activity in vitro and in vivo using hypercholesterolemic zebrafish. Cinnamon and clove extracts (at final 10 μg/mL) had the strongest anti-glycation and antioxidant activity in this study. Cinnamon and clove had the strongest inhibition of activity against copper-mediated low-density lipoprotein (LDL) oxidation and LDL phagocytosis by macrophages. Cinnamon or clove extracts had potent cholesteryl ester transfer protein (CETP) inhibitory activity in a concentration-dependent manner. They exhibited hypolipidemic activity in a hypercholesterolemic zebrafish model; the clove extract-treated group had a 68% and 80% decrease in serum cholesterol and TG levels, respectively. The clove extract-fed group had the smallest increase in body weight and height and the strongest antioxidant activity following a 5-week high cholesterol diet. Hydrophilic ingredients of cinnamon and clove showed potent activities to suppress the incidence of atherosclerosis and diabetes via strong antioxidant potential, prevention of apoA-I glycation and LDL-phagocytosis, inhibition of CETP, and hypolipidemic activity. These results suggest the potential to develop a new functional dietary agent to treat chronic metabolic diseases, such as hyperlipidemia and diabetes.

  15. Humulus japonicus extract exhibits antioxidative and anti-aging effects via modulation of the AMPK-SIRT1 pathway.

    Science.gov (United States)

    Sung, Bokyung; Chung, Ji Won; Bae, Ha Ram; Choi, Jae Sue; Kim, Cheol Min; Kim, Nam Deuk

    2015-05-01

    The perennial herb, Humulus japonicus, has been previously described as possessing potential antituberculosis and anti-inflammatory properties. In the present study, the anti-aging activity of ethanol extracts from the leaves of H. japonicus (HJE) was evaluated in yeast and human fibroblast cells. In addition, the antioxidant activity of HJE was analyzed using free radical scavenging assays. Furthermore, the mechanism underlying the hypothesized HJE-associated extension of lifespan was investigated, and the results indicated that HJE was able to extend the lifespan of yeast cells. Further experiments demonstrated that HJE upregulated the longevity-associated proteins, sirtuin 1 and AMP-activated protein kinase, and effectively inhibited the generation of reactive oxygen species (ROS). In addition, the antioxidative potential of the active constituents of HJE, including luteolin, luteolin 7-glycoside, quercetin and quercitrin, was evaluated and the results demonstrated that these flavonoids were able to scavenge ROS in cell-free and intracellular systems. In summary, the results revealed that HJE possessed the potential for antioxidative activity; however, further in vivo investigations are required with the aim of developing safe, high-efficacy anti-aging agents.

  16. Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70 Function

    Directory of Open Access Journals (Sweden)

    Tawanda Zininga

    2017-07-01

    Full Text Available Malaria parasites are increasingly becoming resistant to currently used antimalarial therapies, therefore there is an urgent need to expand the arsenal of alternative antimalarial drugs. In addition, it is also important to identify novel antimalarial drug targets. In the current study, extracts of two plants, Pterocarpus angolensis and Ziziphus mucronata were obtained and their antimalarial functions were investigated. Furthermore, we explored the capability of the extracts to inhibit Plasmodium falciparum heat shock protein 70 (Hsp70 function. Heat shock protein 70 (Hsp70 are molecular chaperones whose function is to facilitate protein folding. Plasmodium falciparum the main agent of malaria, expresses two cytosol-localized Hsp70s: PfHsp70-1 and PfHsp70-z. The PfHsp70-z has been reported to be essential for parasite survival, while inhibition of PfHsp70-1 function leads to parasite death. Hence both PfHsp70-1 and PfHsp70-z are potential antimalarial drug targets. Extracts of P. angolensis and Z. mucronata inhibited the basal ATPase and chaperone functions of the two parasite Hsp70s. Furthermore, fractions of P. angolensis and Z. mucronata inhibited P. falciparum 3D7 parasite growth in vitro. The extracts obtained in the current study exhibited antiplasmodial activity as they killed P. falciparum parasites maintained in vitro. In addition, the findings further suggest that some of the compounds in P. angolensis and Z. mucronata may target parasite Hsp70 function.

  17. Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70) Function.

    Science.gov (United States)

    Zininga, Tawanda; Anokwuru, Chinedu P; Sigidi, Muendi T; Tshisikhawe, Milingoni P; Ramaite, Isaiah I D; Traoré, Afsatou N; Hoppe, Heinrich; Shonhai, Addmore; Potgieter, Natasha

    2017-07-28

    Malaria parasites are increasingly becoming resistant to currently used antimalarial therapies, therefore there is an urgent need to expand the arsenal of alternative antimalarial drugs. In addition, it is also important to identify novel antimalarial drug targets. In the current study, extracts of two plants, Pterocarpus angolensis and Ziziphus mucronata were obtained and their antimalarial functions were investigated. Furthermore, we explored the capability of the extracts to inhibit Plasmodium falciparum heat shock protein 70 (Hsp70) function. Heat shock protein 70 (Hsp70) are molecular chaperones whose function is to facilitate protein folding. Plasmodium falciparum the main agent of malaria, expresses two cytosol-localized Hsp70s: PfHsp70-1 and PfHsp70-z. The PfHsp70-z has been reported to be essential for parasite survival, while inhibition of PfHsp70-1 function leads to parasite death. Hence both PfHsp70-1 and PfHsp70-z are potential antimalarial drug targets. Extracts of P. angolensis and Z. mucronata inhibited the basal ATPase and chaperone functions of the two parasite Hsp70s. Furthermore, fractions of P. angolensis and Z. mucronata inhibited P. falciparum 3D7 parasite growth in vitro. The extracts obtained in the current study exhibited antiplasmodial activity as they killed P. falciparum parasites maintained in vitro. In addition, the findings further suggest that some of the compounds in P. angolensis and Z. mucronata may target parasite Hsp70 function.

  18. Alpha-fetoprotein, identified as a novel marker for the antioxidant effect of placental extract, exhibits synergistic antioxidant activity in the presence of estradiol.

    Directory of Open Access Journals (Sweden)

    Hye Yeon Choi

    Full Text Available Placenta, as a reservoir of nutrients, has been widely used in medical and cosmetic materials. Here, we focused on the antioxidant properties of placental extract and attempted to isolate and identify the main antioxidant factors. Porcine placental extracts were prepared through homogenization or acid hydrolysis, and their antioxidant activity was investigated in the human keratinocyte HaCaT cell line. Treatment with homogenized placental extract (H-PE increased the cell viability of H2O2-treated HaCaT cells more than two-fold. H-PE treatment suppressed H2O2-induced apoptotic and necrotic cell death and decreased intracellular ROS levels in H2O2-treated HaCaT cells. The antioxidant factors in H-PE were found to be thermo-unstable and were thus expected to include proteins. The candidate antioxidant proteins were fractionated with cation-exchange, anion-exchange, and size-exclusion chromatography, and the antioxidant properties of the chromatographic fractions were investigated. We obtained specific antioxidant fractions that suppressed ROS generation and ROS-induced DNA strand breaks. From silver staining and MALDI-TOF analyses, alpha-fetoprotein (AFP precursor was identified as a main marker for the antioxidant effect of H-PE. Purified AFP or ectopically expressed AFP exhibited synergistic antioxidant activity in the presence of estradiol. Taken together, our data suggest that AFP, a serum glycoprotein produced at high levels during fetal development, is a novel marker protein for the antioxidant effect of the placenta that exhibits synergistic antioxidant activity in the presence of estradiol.

  19. Exhibit Engineering

    DEFF Research Database (Denmark)

    Mortensen, Marianne Foss

    ) a synthesis of the findings from the first two studies with findings from the literature to generate two types of results: a coherent series of suggestions for a design iteration of the studied exhibit as well as a more general normative model for exhibit engineering. Finally, another perspective...

  20. Human Exhibitions

    DEFF Research Database (Denmark)

    Andreassen, Rikke

    From 1870s to 1910s, more than 50 exhibitions of so-called exotic people took place in Denmark. Here large numbers of people of Asian and African origin were exhibited for the entertainment and ‘education’ of a mass audience. Several of these exhibitions took place in Copenhagen Zoo. Here different...... light on the staging of exhibitions, the daily life of the exhibitees, the wider connections between shows across Europe and the thinking of the time on matters of race, science, gender and sexuality. A window onto contemporary racial understandings, the book presents interviews with the descendants...... of displayed people, connecting the attitudes and science of the past with both our (continued) modern fascination with ‘the exotic’, and contemporary language and popular culture. As such, it will be of interest to scholars of sociology, anthropology and history working in the areas of gender and sexuality...

  1. Dolutegravir (S/GSK1349572) exhibits significantly slower dissociation than raltegravir and elvitegravir from wild-type and integrase inhibitor-resistant HIV-1 integrase-DNA complexes.

    Science.gov (United States)

    Hightower, Kendra E; Wang, Ruolan; Deanda, Felix; Johns, Brian A; Weaver, Kurt; Shen, Yingnian; Tomberlin, Ginger H; Carter, H Luke; Broderick, Timothy; Sigethy, Scott; Seki, Takahiro; Kobayashi, Masanori; Underwood, Mark R

    2011-10-01

    The integrase inhibitor (INI) dolutegravir (DTG; S/GSK1349572) has significant activity against HIV-1 isolates with raltegravir (RAL)- and elvitegravir (ELV)-associated resistance mutations. As an initial step in characterizing the different resistance profiles of DTG, RAL, and ELV, we determined the dissociation rates of these INIs with integrase (IN)-DNA complexes containing a broad panel of IN proteins, including IN substitutions corresponding to signature RAL and ELV resistance mutations. DTG dissociates slowly from a wild-type IN-DNA complex at 37°C with an off-rate of 2.7 × 10(-6) s(-1) and a dissociative half-life (t(1/2)) of 71 h, significantly longer than the half-lives for RAL (8.8 h) and ELV (2.7 h). Prolonged binding (t(1/2), at least 5 h) was observed for DTG with IN-DNA complexes containing E92, Y143, Q148, and N155 substitutions. The addition of a second substitution to either Q148 or N155 typically resulted in an increase in the off-rate compared to that with the single substitution. For all of the IN substitutions tested, the off-rate of DTG from IN-DNA complexes was significantly slower (from 5 to 40 times slower) than the off-rate of RAL or ELV. These data are consistent with the potential for DTG to have a higher genetic barrier to resistance, provide evidence that the INI off-rate may be an important component of the mechanism of INI resistance, and suggest that the slow dissociation of DTG may contribute to its distinctive resistance profile.

  2. Malignant progressive tumor cell clone exhibits significant up-regulation of cofilin-2 and 27-kDa modified form of cofilin-1 compared to regressive clone.

    Science.gov (United States)

    Kuramitsu, Yasuhiro; Wang, Yufeng; Okada, Futoshi; Baron, Byron; Tokuda, Kazuhiro; Kitagawa, Takao; Akada, Junko; Nakamura, Kazuyuki

    2013-09-01

    QR-32 is a regressive murine fibrosarcoma cell clone which cannot grow when they are transplanted in mice; QRsP-11 is a progressive malignant tumor cell clone derived from QR-32 which shows strong tumorigenicity. A recent study showed there to be differentially expressed up-regulated and down-regulated proteins in these cells, which were identified by proteomic differential display analyses by using two-dimensional gel electrophoresis and mass spectrometry. Cofilins are small proteins of less than 20 kDa. Their function is the regulation of actin assembly. Cofilin-1 is a small ubiquitous protein, and regulates actin dynamics by means of binding to actin filaments. Cofilin-1 plays roles in cell migration, proliferation and phagocytosis. Cofilin-2 is also a small protein, but it is mainly expressed in skeletal and cardiac muscles. There are many reports showing the positive correlation between the level of cofilin-1 and cancer progression. We have also reported an increased expression of cofilin-1 in pancreatic cancer tissues compared to adjacent paired normal tissues. On the other hand, cofilin-2 was significantly less expressed in pancreatic cancer tissues. Therefore, the present study investigated the comparison of the levels of cofilin-1 and cofilin-2 in regressive QR-32 and progressive QRsP-11cells by western blotting. Cofilin-2 was significantly up-regulated in QRsP-11 compared to QR-32 cells (p<0.001). On the other hand, the difference of the intensities of the bands of cofilin-1 (18 kDa) in QR-32 and QRsP-11 was not significant. However, bands of 27 kDa showed a quite different intensity between QR-32 and QRsP-11, with much higher intensities in QRsP-11 compared to QR-32 (p<0.001). These results suggested that the 27-kDa protein recognized by the antibody against cofilin-1 is a possible biomarker for progressive tumor cells.

  3. A mineral and antioxidant-rich extract from the red marine Algae Alsidium corallinum exhibits cytoprotective effects against potassium bromate-induced erythrocyte oxidative damages in mice.

    Science.gov (United States)

    Ben Saad, Hajer; Nasri, Imen; Elwej, Awatef; Krayem, Najeh; Jarraya, Raoudha; Kallel, Choumous; Zeghal, Najiba; Amara, Ibtissem Ben

    2014-07-01

    The present study was carried out to investigate potassium bromate toxicity in mice and the corrective effects of marine algae Alsidium corallinum. The red algae demonstrated its rich composition in phenols, triterpenes, flavonoids, alkaloids, tropolones, sodium, potassium, calcium, magnesium, iron, copper, and zinc. To confirm its antioxidant potential, an in vivo study was performed on adult mice. The animals were divided into four groups: group I were used as controls, group II received potassium bromate (0.5 g/L) via drinking water, group III received potassium bromate (0.5 g/L) by the same route as group II and 7% of A. corallinum ethanolic extract via their diet, and group IV received only 7% of algae. The potassium bromate-treated group showed a significant decrease in erythrocyte, platelet, hemoglobin, and hematocrit values and a significant increase in total white blood cells, compared to those of controls. While, superoxide dismutase, catalase, glutathione, and vitamin C values were decreased by potassium bromate treatment, lipid peroxidation (as malondialdehyde) and erythrocyte osmotic fragility values were increased. Interestingly, potassium bromate treatment showed significant genotoxic effects, as demonstrated by DNA degradation. These changes were confirmed by blood smears histopathological observations which were marked by a necrosis and a decrease of erythrocytes number. A. corallinum extract appeared to be effective against hematotoxic and genotoxic changes induced by potassium bromate, as evidenced by the improvement of the parameters cited above.

  4. Exhibit Engineering

    DEFF Research Database (Denmark)

    Mortensen, Marianne Foss

    of tools and processes to guide the design of educational science exhibits. The guiding paradigm for this development is design-based research, which is characterised by an iterative cycle of design, enactment, and analysis. In the design phase, an educational intervention is planned and carried out based...... on a hypothesised learning process and the means of supporting it. In the enactment phase, the educational intervention is implemented (i.e. the planned lesson is taught, or the museum exhibit is opened to the public). Finally, the analysis phase establishes causality between emergent characteristics...... of the learning outcomes and the design characteristics of the intervention. The analysis process can yield two types of outcomes: Suggestions for the refinement of the specific design in question, and “humble” theory, which is theory that can guide the design of a category of educational interventions...

  5. Extracting biologically significant patterns from short time series gene expression data

    Directory of Open Access Journals (Sweden)

    McGinnis Thomas

    2009-08-01

    Full Text Available Abstract Background Time series gene expression data analysis is used widely to study the dynamics of various cell processes. Most of the time series data available today consist of few time points only, thus making the application of standard clustering techniques difficult. Results We developed two new algorithms that are capable of extracting biological patterns from short time point series gene expression data. The two algorithms, ASTRO and MiMeSR, are inspired by the rank order preserving framework and the minimum mean squared residue approach, respectively. However, ASTRO and MiMeSR differ from previous approaches in that they take advantage of the relatively few number of time points in order to reduce the problem from NP-hard to linear. Tested on well-defined short time expression data, we found that our approaches are robust to noise, as well as to random patterns, and that they can correctly detect the temporal expression profile of relevant functional categories. Evaluation of our methods was performed using Gene Ontology (GO annotations and chromatin immunoprecipitation (ChIP-chip data. Conclusion Our approaches generally outperform both standard clustering algorithms and algorithms designed specifically for clustering of short time series gene expression data. Both algorithms are available at http://www.benoslab.pitt.edu/astro/.

  6. Holstein-Friesian calves selected for divergence in residual feed intake during growth exhibited significant but reduced residual feed intake divergence in their first lactation.

    Science.gov (United States)

    Macdonald, K A; Pryce, J E; Spelman, R J; Davis, S R; Wales, W J; Waghorn, G C; Williams, Y J; Marett, L C; Hayes, B J

    2014-03-01

    Residual feed intake (RFI), as a measure of feed conversion during growth, was estimated for around 2,000 growing Holstein-Friesian heifer calves aged 6 to 9 mo in New Zealand and Australia, and individuals from the most and least efficient deciles (low and high RFI phenotypes) were retained. These animals (78 New Zealand cows, 105 Australian cows) were reevaluated during their first lactation to determine if divergence for RFI observed during growth was maintained during lactation. Mean daily body weight (BW) gain during assessment as calves had been 0.86 and 1.15 kg for the respective countries, and the divergence in RFI between most and least efficient deciles for growth was 21% (1.39 and 1.42 kg of dry matter, for New Zealand and Australia, respectively). At the commencement of evaluation during lactation, the cows were aged 26 to 29 mo. All were fed alfalfa and grass cubes; it was the sole diet in New Zealand, whereas 6 kg of crushed wheat/d was also fed in Australia. Measurements of RFI during lactation occurred for 34 to 37 d with measurements of milk production (daily), milk composition (2 to 3 times per week), BW and BW change (1 to 3 times per week), as well as body condition score (BCS). Daily milk production averaged 13.8 kg for New Zealand cows and 20.0 kg in Australia. No statistically significant differences were observed between calf RFI decile groups for dry matter intake, milk production, BW change, or BCS; however a significant difference was noted between groups for lactating RFI. Residual feed intake was about 3% lower for lactating cows identified as most efficient as growing calves, and no negative effects on production were observed. These results support the hypothesis that calves divergent for RFI during growth are also divergent for RFI when lactating. The causes for this reduced divergence need to be investigated to ensure that genetic selection programs based on low RFI (better efficiency) are robust. Copyright © 2014 American Dairy

  7. Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity

    Science.gov (United States)

    2012-01-01

    Background As proinflammatory cytokines seem to play a role in discogenic back pain, substances exhibiting anti-inflammatory effects on intervertebral disc cells may be used as minimal-invasive therapeutics for intradiscal/epidural injection. The purpose of this study was to investigate the anti-inflammatory and anti-catabolic potential of curcuma, which has been used in the Indian Ayurvedic medicine to treat multiple ailments for a long time. Methods Human disc cells were treated with IL-1β to induce an inflammatory/catabolic cascade. Different extracts of curcuma as well as curcumin (= a component selected based on results with curcuma extracts and HPLC/MS analysis) were tested for their ability to reduce mRNA expression of proinflammatory cytokines and matrix degrading enzymes after 6 hours (real-time RT-PCR), followed by analysis of typical inflammatory signaling mechanisms such as NF-κB (Western Blot, Transcription Factor Assay), MAP kinases (Western Blot) and Toll-like receptors (real-time RT-PCR). Quantitative data was statistically analyzed using a Mann Whitney U test with a significance level of p curcuma DMSO extract significantly reduced levels of IL-6, MMP1, MMP3 and MMP13. The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1β, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-α. Pathway analysis indicated that curcumin did not show involvement of NF-κB, but down-regulated TLR2 expression and inhibited the MAP kinase JNK while activating p38 and ERK. Conclusions Based on its anti-inflammatory and anti-catabolic effects, intradiscal injection of curcumin may be an attractive treatment alternative. However, whether the anti-inflammatory properties in vitro lead to analgesia in vivo will need to be confirmed in an appropriate animal model. PMID:22909087

  8. Immature Citrus sunki peel extract exhibits antiobesity effects by β-oxidation and lipolysis in high-fat diet-induced obese mice.

    Science.gov (United States)

    Kang, Seong-Il; Shin, Hye-Sun; Kim, Hyo-Min; Hong, Youn-Suk; Yoon, Seon-A; Kang, Seung-Woo; Kim, Jeong-Hwan; Kim, Moo-Han; Ko, Hee-Chul; Kim, Se-Jae

    2012-01-01

    The peel of Citrus sunki HORT. ex TANAKA has been widely used in traditional Asian medicine for the treatment of many diseases, including indigestion and bronchial asthma. In this study, we investigated the antiobesity activity of immature C. sunki peel extract (designated CSE) using high-fat diet (HFD)-induced obese C57BL/6 mice and mature 3T3-L1 adipocytes. In the animal study, body weight gain, adipose tissue weight, serum total cholesterol, and triglyceride in the CSE-administered group decreased significantly compared to the HFD group. Also, CSE supplementation reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase. Moreover, it significantly decreased the accumulation of fatty droplets in liver tissue, suggesting a protective effect against HFD-induced hepatic steatosis. Dietary supplementation with CSE reversed the HFD-induced decrease in the phosphorylation levels of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), which are related to fatty acid β-oxidation, in the epididymal adipose tissue. Also, CSE increased AMPK and ACC phosphorylation in mature 3T3-L1 adipocytes. CSE also enhanced lipolysis by phosphorylation of cAMP-dependent protein kinase (PKA) and hormone-sensitive lipase (HSL) in mature 3T3-L1 adipocytes. These results suggest that CSE had an antiobesity effect via elevated β-oxidation and lipolysis in adipose tissue.

  9. Crude extract and purified components isolated from the stems of Tinospora crispa exhibit positive inotropic effects on the isolated left atrium of rats

    DEFF Research Database (Denmark)

    Praman, Siwaporn; Mulvany, Michael J.; Williams, David E.

    2013-01-01

    ETHNOPHARMACOLOGICAL RELEVANCE: Tinospora crispa has been used in folkloric medicine for the control of blood pressure. We previously found that an extract of Tinospora crispa and its constituents effect the heart rate and blood pressure in anesthetized rats. AIM OF THE STUDY: The aim...... was to investigate the effects and mechanisms of the Tinospora crispa extract and bioactive components on the rat isolated left atria. MATERIALS AND METHODS: Air-dried stems of Tinospora crispa were extracted with water, followed by partitioning with chloroform, ethyl acetate, and finally by n-butanol. The n......-butanol soluble material was concentrated and dried under reduced pressure and lyophilized to obtain a crude powder (Tinospora crispa extract). The active components of Tinospora crispa extract were separated by column chromatography and preparative HPLC. The effects and mechanisms of the n-butanol extract...

  10. Allium stipitatum Extract Exhibits In Vivo Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus and Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model

    Science.gov (United States)

    Karunanidhi, Arunkumar; Jeevajothi Nathan, Jayakayatri; van Belkum, Alex

    2017-01-01

    The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (Allium stipitatum) were explored in a mice burn model infected with methicillin-resistant Staphylococcus aureus (MRSA). Hexane (ASHE) and dichloromethane (ASDE) extracts were tested. Female BALB/c mice were inflicted with third-degree thermal injury followed by infection with MRSA. ASHE and ASDE formulated with simple ointment base (SOB) at concentrations of 1%, 2%, and 5% (w/w) were topically applied to burn wounds twice a day for 20 days. Silver sulfadiazine (1%) served as drug positive control. Microbiological analysis was carried out on 1, 2, 3, 4, and 5 days postwounding (dpw) and histopathological analysis at the end of the experiment (20 dpw). Both ointments demonstrated strong antibacterial activity with complete elimination of MRSA at 48–72 h after infection. The rate of wound contraction was higher (95–100%) in mice groups treated with ASHE and ASDE ointments after 15 dpw. Histological analysis revealed significant increase (p antibacterial as well as promising alternatives in managing thermal injuries. PMID:28321262

  11. Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity

    Directory of Open Access Journals (Sweden)

    Klawitter Marina

    2012-08-01

    Full Text Available Abstract Background As proinflammatory cytokines seem to play a role in discogenic back pain, substances exhibiting anti-inflammatory effects on intervertebral disc cells may be used as minimal-invasive therapeutics for intradiscal/epidural injection. The purpose of this study was to investigate the anti-inflammatory and anti-catabolic potential of curcuma, which has been used in the Indian Ayurvedic medicine to treat multiple ailments for a long time. Methods Human disc cells were treated with IL-1β to induce an inflammatory/catabolic cascade. Different extracts of curcuma as well as curcumin (= a component selected based on results with curcuma extracts and HPLC/MS analysis were tested for their ability to reduce mRNA expression of proinflammatory cytokines and matrix degrading enzymes after 6 hours (real-time RT-PCR, followed by analysis of typical inflammatory signaling mechanisms such as NF-κB (Western Blot, Transcription Factor Assay, MAP kinases (Western Blot and Toll-like receptors (real-time RT-PCR. Quantitative data was statistically analyzed using a Mann Whitney U test with a significance level of p  Results Results indicate that the curcuma DMSO extract significantly reduced levels of IL-6, MMP1, MMP3 and MMP13. The DMSO-soluble component curcumin, whose occurrence within the DMSO extract was verified by HPLC/MS, reduced levels of IL-1β, IL-6, IL-8, MMP1, MMP3 and MMP13 and both caused an up-regulation of TNF-α. Pathway analysis indicated that curcumin did not show involvement of NF-κB, but down-regulated TLR2 expression and inhibited the MAP kinase JNK while activating p38 and ERK. Conclusions Based on its anti-inflammatory and anti-catabolic effects, intradiscal injection of curcumin may be an attractive treatment alternative. However, whether the anti-inflammatory properties in vitro lead to analgesia in vivo will need to be confirmed in an appropriate animal model.

  12. Extracts Obtained from Pterocarpus angolensis DC and Ziziphus mucronata Exhibit Antiplasmodial Activity and Inhibit Heat Shock Protein 70 (Hsp70) Function

    National Research Council Canada - National Science Library

    Tawanda Zininga; Chinedu P Anokwuru; Muendi T Sigidi; Milingoni P Tshisikhawe; Isaiah I D Ramaite; Afsatou N Traore; Heinrich Hoppe; Addmore Shonhai; Natasha Potgieter

    2017-01-01

    .... In addition, it is also important to identify novel antimalarial drug targets. In the current study, extracts of two plants, Pterocarpus angolensis and Ziziphus mucronata were obtained and their antimalarial functions were investigated...

  13. A Novel Approach to Extract Significant Patterns of Travel Time Intervals of Vehicles from Freeway Gantry Timestamp Sequences

    Directory of Open Access Journals (Sweden)

    Jing-Doo Wang

    2017-08-01

    Full Text Available It is attractive to extract and determine the key features of traffic patterns for mitigating road congestion and predicting travel time of vehicles in traffic analysis. Based on the previous work that is a scalable approach via a Hadoop MapReduce programming model, this paper aims to extract significant patterns of travel time intervals of vehicles from freeway traffic in Taiwan, and meanwhile to compute the statistics of these patterns from the point of view one may concern. Experimental resources are the records of timestamp gantry sequences of vehicles passed in five months from 2016/11 to 2017/3 that were downloaded from the Traffic Data Collection System, one of Taiwan government open data platforms. To select one specific gantry sequence for demonstration, the longest sequence on the trip within the Taiwan National Freeway No. 5 is selected. Experimental results show that some statistics of vehicle travel time intervals according to 24 h per day are computed for illustration. These statistics can not only provide clues to experts to analyze traffic congestions, but also help drivers how to avoid rush hours. Furthermore, this work is able to handle a larger amount of real data and be promising for further traffic and transportation research in the future.

  14. Collagen Extracted from Persian Gulf Squid Exhibits Anti-Cytotoxic Properties on Apple Pectic Treated Cells: Assessment in an In Vitro Bioassay Model

    Directory of Open Access Journals (Sweden)

    Ladan DELPHI

    2016-10-01

    Full Text Available Background: Collagen-based three-dimensional (3D in vitro systems have been introduced to study the physiological states of cells. As a biomolecule, collagen is usually extracted from terrestrial animals whilst aquatic animals like squid contain large amounts of collagen.Methods: In order to make effective use of marine organisms, we selected Persian Gulf squid in 2015 to extract the required collagen. Then, a 3D culture system based on the extracted collagen was applied to investigate cellular mechanisms in a native microenvironment. The formed collagen gel was used to investigate the growth of MDA-MB-231 breast cancer cells as well as responses to pectic acid.Results: The results revealed that the extracted collagen contained α, ß and γ components with high water holding capacity. This collagen formed a gel-like structure, which could promote the proliferation of MDA-MB-231 breast cancer cells. The MDA-MB-231 cells’ viability in presence of pectic acid, demonstrating the cells’ behavior in a 3D culture system. Conclusion: It seems that the collagen extracted from squid skin has type I collagen properties. It might be used as a substrate in 3D cell culture systems. Keywords: Cell culture, Collagen, Pectic acid, Squid, 3D culture system 

  15. Polyyne-Enriched Extract from Oplopanax elatus Significantly Ameliorates the Progression of Colon Carcinogenesis in ApcMin/+ Mice

    Directory of Open Access Journals (Sweden)

    Xin Qiao

    2017-09-01

    Full Text Available Colorectal cancer (CRC is the third most common cancer in the world. Oplopanax elatus is widely used in traditional medicine. However, little is known about its pharmacological effects and bioactive compounds. We evaluated the effects of the polyyne-enriched extract from O. elatus (PEO on the progression of colon carcinogenesis in ApcMin/+ mice. In addition, these effects were also investigated in HCT116 and SW480 cells. After PEO oral administration (0.2% diet for 12 weeks, PEO significantly improved body weight changes and reduced the tumor burden and tumor multiplicity compared with the untreated mice. Meanwhile, western blot and immunohistochemistry results showed PEO significantly reduced the expression of β-catenin and cyclinD1 in both small intestine and the colon tissues compared with the untreated mice. In addition, PEO treatment significant decreased the cell viability in both HCT116 and SW480 cell lines. It also decreased the levels of β-catenin, cyclinD1, c-myc and p-GSK-3β in HCT116 and SW480 cells at 25 μM. These results indicate that PEO may have potential value in prevention of colon cancer by down-regulating Wnt-related protein.

  16. Acellular bone marrow extracts significantly enhance engraftment levels of human hematopoietic stem cells in mouse xeno-transplantation models.

    Directory of Open Access Journals (Sweden)

    Kazem Zibara

    Full Text Available Hematopoietic stem cells (HSC derived from cord blood (CB, bone marrow (BM, or mobilized peripheral blood (PBSC can differentiate into multiple lineages such as lymphoid, myeloid, erythroid cells and platelets. The local microenvironment is critical to the differentiation of HSCs and to the preservation of their phenotype in vivo. This microenvironment comprises a physical support supplied by the organ matrix as well as tissue specific cytokines, chemokines and growth factors. We investigated the effects of acellular bovine bone marrow extracts (BME on HSC in vitro and in vivo. We observed a significant increase in the number of myeloid and erythroid colonies in CB mononuclear cells (MNC or CB CD34+ cells cultured in methylcellulose media supplemented with BME. Similarly, in xeno-transplantation experiments, pretreatment with BME during ex-vivo culture of HSCs induced a significant increase in HSC engraftment in vivo. Indeed, we observed both an increase in the number of differentiated myeloid, lymphoid and erythroid cells and an acceleration of engraftment. These results were obtained using CB MNCs, BM MNCs or CD34(+ cells, transplanted in immuno-compromised mice (NOD/SCID or NSG. These findings establish the basis for exploring the use of BME in the expansion of CB HSC prior to HSC Transplantation. This study stresses the importance of the mechanical structure and soluble mediators present in the surrounding niche for the proper activity and differentiation of stem cells.

  17. Ethanol extract of lotus (Nelumbo nucifera) root exhibits an anti-adipogenic effect in human pre-adipocytes and anti-obesity and anti-oxidant effects in rats fed a high-fat diet.

    Science.gov (United States)

    You, Jeong Soon; Lee, Yun Ju; Kim, Kyoung Soo; Kim, Sung Hoon; Chang, Kyung Ja

    2014-03-01

    Lotus (Nelumbo Nucifera) root, a well-known medicinal plant in Asia, is reported to have various therapeutic benefits, including anti-diabetes, anti-hypertension, and anti-hyperlipidaemia. We hypothesized that the ethanol extract of lotus root (ELR) would exhibit an anti-adipogenic effect in human pre-adipocytes as well as anti-obesity and anti-oxidant effects in rats fed a high-fat diet. Treatment with ELR in human pre-adipocytes resulted in inhibition of lipid accumulation and attenuated expression of adipogenic transcription factors such as peroxisome proliferator-activated receptor gamma and adipocyte marker genes, such as glucose transporter 4 and leptin. Administration of ELR resulted in a significant decrease in relative weights of adipose tissues in rats fed a high-fat diet. Consumption of a high-fat diet resulted in an increase in serum total cholesterol (TC) and triglyceride (TG) levels; however, administration of ELR resulted in a decrease in the levels of TC and TG. Administration of ELR resulted in a decrease in the level of serum leptin and insulin. Administration of ELR in rats fed a high-fat diet resulted in a decrease in hepatic thiobarbituric acid reactive substance content, elevated by a high-fat diet and an increase in superoxide dismutase activity and hepatic glutathione content. These results suggest that lotus root exerts anti-oxidant and anti-obesity effects and could be used as a functional and nutraceutical ingredient in combatting obesity-related diseases.

  18. Pyrolysates of raw vitrinites and their residues after CS2-NMP solvent extraction and its significance for petroleum geology

    Institute of Scientific and Technical Information of China (English)

    LIU Dayong; PENG Ping'an

    2006-01-01

    Binary solvent (CS2-NMP) has extreme high extraction ability to coals, and it can extract most bitumens out of coals and vitrinites. And large amount of messages on side chains and their distribution character in vitrinites should be acquired through flash pyrolysis before and after binary solvent (CS2-NMP) extraction. A few low maturated coals have been selected and vitrinites are handpicked from coals. Then vitrinites have been extracted using different solvents in the order of polarity. Flash pyrolysis-Gas Chromatography/Mass spectrum has been applied to samples. The result shows that CS2-NMP is efficient for the extraction of vitirnites, giving much higher extraction yield than common solvents. Production ratio of liquid hydrocarbons in pyrolysates of vitrinites extracted with CS2-NMP is lower than that of raw vitrinites. And relative ratio of each component in pyrolysates has changed apparently. Production ratio of aliphatic hydrocarbons, especially those long chain aliphatics have decreased much after mixed solvent extraction. It shows that bitumens extracted with CS2-NMP have largely contributed to pyrolysates, especially those aliphatics in pyrolysates.

  19. Crocus sativus stigma extract and its major constituent crocin possess significant antiproliferative properties against human prostate cancer.

    Science.gov (United States)

    D'Alessandro, Anna M; Mancini, Andrea; Lizzi, Anna Rita; De Simone, Angela; Marroccella, Carmine Esposito; Gravina, Giovanni Luca; Tatone, Carla; Festuccia, Claudio

    2013-01-01

    In this study, we investigated the antiproliferative effects of saffron extract (SE) and its major constituent crocin on 5 different malignant and 2 nonmalignant prostate cancer cell lines. Using high performance liquid chromatography (HPLC), the purity and content of crocin were determined. All cells were incubated with different concentrations of SE or crocin for 48 h. Cell cycle and apoptosis were also evaluated. In a time- and concentration-dependent manner, both SE and crocin reduced cell proliferation in all malignant cell lines with IC50 values ranging between 0.4 and 4 mg/ml for SE and between 0.26 and 0.95 mM/ml for crocin. Nonmalignant cells were not affected. Flow cytometry profiles revealed that most cells were arrested at G0/G1 phase with a significant presence of apoptotic cells. Western blot analysis revealed that the expression of Bcl-2 was strikingly downregulated, whereas Bax was upregulated. Analysis of caspase activity indicated a caspase-dependent pathway with involvement of caspase-9 activation, suggesting an intrinsic pathway. Based on these findings, it can be concluded that both SE and crocin can inhibit cell proliferation, arrest cell cycle progression, inducing apoptosis in prostate cancer. Consequently, these agents could potentially be used as a chemopreventive as well as a chemotherapeutic agent for prostate cancer management.

  20. Significant Enrichment of Polyunsaturated Fatty Acids (PUFAs) in the Lipids Extracted by Supercritical CO2 from the Livers of Australian Rock Lobsters (Jasus edwardsii).

    Science.gov (United States)

    Nguyen, Trung T; Zhang, Wei; Barber, Andrew R; Su, Peng; He, Shan

    2015-05-13

    Australian rock lobster (Jasus edwardsii) liver contains approximately 24.3% (w/w) lipids, which can contain a high amount of polyunsaturated fatty acids (PUFAs). However, this material has been found to be contaminated with arsenic (240 mg/kg) and cadmium (8 mg/kg). The high level of contaminants in the raw material and the large amount of PUFAs in the lipids prove a significant challenge in the extraction of high-quality lipids from this byproduct by conventional methods. Supercritical carbon dioxide (SC-CO2) extraction is a highly promising technology for lipid extraction with advantages including low contamination and low oxidation. The technique was optimized to achieve nearly 94% extraction of lipids relative to conventional Soxhlet extraction in Australian rock lobster liver at conditions of 35 MPa and 50 °C for 4 h. The extracted lipids are significantly enriched in PUFAs at 31.3% of total lipids, 4 times higher than those in the lipids recovered by Soxhlet extraction (7.8%). Specifically, the concentrations of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) in SC-CO2 extraction are 7 times higher than those obtained by Soxhlet extraction. Moreover, very small amounts of toxic heavy metals such as lead (Pb), arsenic (As), mercury (Hg), and cadmium (Cd) were detected in the SC-CO2-extracted lipids, 0.5-27 times lower than those in the Soxhlet-extracted lipids, which are 40-200 times lower than the regulatory limit maximum values. The low levels of contaminants and the high proportion of PUFAs (dominated by DHA and EPA) found in the SC-CO2-extracted lipids from Australian rock lobster liver suggest that the material could potentially be used as a valuable source of essential fatty acids for human consumption.

  1. Estimates of Soil Bacterial Ribosome Content and Diversity Are Significantly Affected by the Nucleic Acid Extraction Method Employed.

    Science.gov (United States)

    Wüst, Pia K; Nacke, Heiko; Kaiser, Kristin; Marhan, Sven; Sikorski, Johannes; Kandeler, Ellen; Daniel, Rolf; Overmann, Jörg

    2016-05-01

    Modern sequencing technologies allow high-resolution analyses of total and potentially active soil microbial communities based on their DNA and RNA, respectively. In the present study, quantitative PCR and 454 pyrosequencing were used to evaluate the effects of different extraction methods on the abundance and diversity of 16S rRNA genes and transcripts recovered from three different types of soils (leptosol, stagnosol, and gleysol). The quality and yield of nucleic acids varied considerably with respect to both the applied extraction method and the analyzed type of soil. The bacterial ribosome content (calculated as the ratio of 16S rRNA transcripts to 16S rRNA genes) can serve as an indicator of the potential activity of bacterial cells and differed by 2 orders of magnitude between nucleic acid extracts obtained by the various extraction methods. Depending on the extraction method, the relative abundances of dominant soil taxa, in particular Actino bacteria and Proteobacteria, varied by a factor of up to 10. Through this systematic approach, the present study allows guidelines to be deduced for the selection of the appropriate extraction protocol according to the specific soil properties, the nucleic acid of interest, and the target organisms. Copyright © 2016, American Society for Microbiology. All Rights Reserved.

  2. Estimates of Soil Bacterial Ribosome Content and Diversity Are Significantly Affected by the Nucleic Acid Extraction Method Employed

    Science.gov (United States)

    Wüst, Pia K.; Nacke, Heiko; Kaiser, Kristin; Marhan, Sven; Sikorski, Johannes; Kandeler, Ellen; Daniel, Rolf

    2016-01-01

    Modern sequencing technologies allow high-resolution analyses of total and potentially active soil microbial communities based on their DNA and RNA, respectively. In the present study, quantitative PCR and 454 pyrosequencing were used to evaluate the effects of different extraction methods on the abundance and diversity of 16S rRNA genes and transcripts recovered from three different types of soils (leptosol, stagnosol, and gleysol). The quality and yield of nucleic acids varied considerably with respect to both the applied extraction method and the analyzed type of soil. The bacterial ribosome content (calculated as the ratio of 16S rRNA transcripts to 16S rRNA genes) can serve as an indicator of the potential activity of bacterial cells and differed by 2 orders of magnitude between nucleic acid extracts obtained by the various extraction methods. Depending on the extraction method, the relative abundances of dominant soil taxa, in particular Actinobacteria and Proteobacteria, varied by a factor of up to 10. Through this systematic approach, the present study allows guidelines to be deduced for the selection of the appropriate extraction protocol according to the specific soil properties, the nucleic acid of interest, and the target organisms. PMID:26896137

  3. Eugenia jambolana (Java Plum) Fruit Extract Exhibits Anti-Cancer Activity against Early Stage Human HCT-116 Colon Cancer Cells and Colon Cancer Stem Cells.

    Science.gov (United States)

    Charepalli, Venkata; Reddivari, Lavanya; Vadde, Ramakrishna; Walia, Suresh; Radhakrishnan, Sridhar; Vanamala, Jairam K P

    2016-02-26

    The World Health Organization predicts over a 70% increase in cancer incidents in developing nations over the next decade. Although these nations have limited access to novel therapeutics, they do have access to foods that contain chemopreventive bioactive compounds such as anthocyanins, and as such, consumption of these foods can be encouraged to combat cancer. We and others have previously characterized the anti-colon cancer properties of dietary anthocyanins from different sources. Eugenia jambolana (Java plum) is a tropical medicinal fruit rich in anthocyanins, however, its anti-colon cancer properties are not well characterized. Furthermore, recent evidence suggests that colon cancer stem cells (colon CSCs) promote resistance to chemotherapy, relapse of tumors and contribute to poor prognosis. The objectives of this study were to 1) characterize the anthocyanin profile of Java plum using HPLC-MS; and 2) determine the anti-proliferative (cell counting and MTT) and pro-apoptotic (TUNEL and caspase 3/7 glo assay) properties of Java plum fruit extract (JPE) using HCT-116 colon cancer cell line and colon CSCs (positive for CD 44, CD 133 and ALDH1b1 markers). HPLC-MS analysis showed that JPE contains a variety of anthocyanins including glucosides of delphinidin, cyanidin, petunidin, peonidin and malvidin. JPE anthocyanins suppressed (p cancer activity of JPE, and its molecular mechanisms using pre-clinical models of colon cancer.

  4. EXTRACT

    DEFF Research Database (Denmark)

    Pafilis, Evangelos; Buttigieg, Pier Luigi; Ferrell, Barbra

    2016-01-01

    The microbial and molecular ecology research communities have made substantial progress on developing standards for annotating samples with environment metadata. However, sample manual annotation is a highly labor intensive process and requires familiarity with the terminologies used. We have the...... and text-mining-assisted curation revealed that EXTRACT speeds up annotation by 15-25% and helps curators to detect terms that would otherwise have been missed.Database URL: https://extract.hcmr.gr/....

  5. Herbal tea extract combined with light-induced significant in vitro cytotoxicity of human bladder cancer cells

    Science.gov (United States)

    Nseyo, Unyime; Kim, Albert; Stavropoulos, Nicholas E.; Skalkos, Dimitris; Nseyo, U. U.; Chung, Theodore D.

    2005-04-01

    The anti-inflammatory, anti-microbial, antiviral, and antidepressant activities of the Greek herb, Hypericum Perforatum L, HP L, have been attributed to the total extract or single constituents. We investigated the use of the extract,specifically of the polar methanolic fraction (PMF) of Epirus"HPL in photodynamic therapy (PDT) alone and in combination with recombinant Interferon-a2b (IFN) and gemcitabine (GCB) in the treatment of human bladder cancer cells. The PMF was extracted from the dry herb with methanol, followed by liquid-liquid extraction with petroleum ether. T-24 bladder cancer cells were plated (105 cells/well) and placed in the incubator (370 C, 5%CO) for 24 hours prior to addition of drugs. PMF 60ug/ml was added and incubation continued. After 24 hours, the cells were subjected to laser light (630nm) treatment with 0, 1, 4 and 8 Joules. After reincubation for 24 hours, IFN, (50,000 IU) or GCB, (2ug/ml) was added to the PDT-treated cells. After this incubation cell survival was assessed by the MTT assay. PMF-PDT alone-induced percent cell kill of 0%, 8%, 44% and 80% versus 31%, 64 and 86 % for PMF-PDT and IFN, versus 63%, 80% and 88% for MPF-PDT plus GCB at 1, 2, 4 and 8 Joules respectively. IFN and GCB induced 20% and 53% cell kill respectively. Our data suggest that MPF may be an effective agent for in vitro photodynamic therapy. PMF-PDT combined with Intron A, or gemcitabine achieved improved kill of cultured bladder cancer cells. Confirmation of these results in preclinical studies may lead to clinical trials.

  6. Surface functionalization of bioactive glasses with natural molecules of biological significance, part II: Grafting of polyphenols extracted from grape skin

    Science.gov (United States)

    Zhang, Xin; Ferraris, Sara; Prenesti, Enrico; Verné, Enrica

    2013-12-01

    Polyphenols, as one of the most important family of phytochemicals protective substances from grape fruit, possess various biological activities and health-promoting benefits, for example: inhibition of some degenerative diseases, cardiovascular diseases and certain types of cancers, reduction of plasma oxidative stress and slowing aging. The combination of polyphenols and biomaterials may have good potential to reach good bioavailability and controlled release, as well as to give biological signaling properties to the biomaterial surfaces. In this research, conventional solvent extraction was developed for obtaining polyphenols from dry grape skins. The Folin&Ciocalteu method was used to determine the amount of total polyphenols in the extracts. Surface functionalization of two bioactive glasses (SCNA and CEL2) was performed by grafting the extracted polyphenols on their surfaces. The effectiveness of the functionalization was tested by UV spectroscopy, which analyzes the amount of polyphenols in the uptake solution (before and after functionalization) and on solid samples, and XPS, which analyzes the presence of phenols on the material surface.

  7. Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Anti-Tumor Activity in Cancer Cells that Display Resistance to Proapoptotic Stimuli: an Investigation of Structure-Activity Relationship and Mechanistic Insight

    Science.gov (United States)

    Lamoral-Theys, Delphine; Andolfi, Anna; Van Goietsenoven, Gwendoline; Cimmino, Alessio; Le Calvé, Benjamin; Wauthoz, Nathalie; Mégalizzi, Véronique; Gras, Thierry; Bruyère, Céline; Dubois, Jacques; Mathieu, Véronique; Kornienko, Alexander; Kiss, Robert; Evidente, Antonio

    2011-01-01

    Twenty-two lycorine-related compounds were investigated for in vitro anti-tumor activity using four cancer cell lines displaying different levels of resistance to pro-apoptotic stimuli and two cancer cell lines sensitive to pro-apoptotic stimuli. Lycorine and six of its congeners exhibited potency in the single-digit micromolar range, while no compound appeared more active than lycorine. Lycorine also displayed the highest potential (in vitro) therapeutic ratio, being at least 15 times more active against cancer than normal cells. Our studies also showed that lycorine exerts its in vitro anti-tumor activity through cytostatic rather than cytotoxic effects. Furthermore, lycorine provided significant therapeutic benefit in mice bearing brain grafts of the B16F10 melanoma model at non-toxic doses. Thus, the results of the current study make lycorine an excellent lead for the generation of compounds able to combat cancers, which are naturally resistant to pro-apoptotic stimuli, such as glioblastoma, melanoma, non-small-cell-lung cancers, metastatic cancers, among others. PMID:19788245

  8. Lycorine, the main phenanthridine Amaryllidaceae alkaloid, exhibits significant antitumor activity in cancer cells that display resistance to proapoptotic stimuli: an investigation of structure-activity relationship and mechanistic insight.

    Science.gov (United States)

    Lamoral-Theys, Delphine; Andolfi, Anna; Van Goietsenoven, Gwendoline; Cimmino, Alessio; Le Calvé, Benjamin; Wauthoz, Nathalie; Mégalizzi, Véronique; Gras, Thierry; Bruyère, Céline; Dubois, Jacques; Mathieu, Véronique; Kornienko, Alexander; Kiss, Robert; Evidente, Antonio

    2009-10-22

    Twenty-two lycorine-related compounds were investigated for in vitro antitumor activity using four cancer cell lines displaying different levels of resistance to proapoptotic stimuli and two cancer cell lines sensitive to proapoptotic stimuli. Lycorine and six of its congeners exhibited potency in the single-digit micromolar range, while no compound appeared more active than lycorine. Lycorine also displayed the highest potential (in vitro) therapeutic ratio, being at least 15 times more active against cancer than normal cells. Our studies also showed that lycorine exerts its in vitro antitumor activity through cytostatic rather than cytotoxic effects. Furthermore, lycorine provided significant therapeutic benefit in mice bearing brain grafts of the B16F10 melanoma model at nontoxic doses. Thus, the results of the current study make lycorine an excellent lead for the generation of compounds able to combat cancers, which are naturally resistant to proapoptotic stimuli, such as glioblastoma, melanoma, non-small-cell-lung cancers, and metastatic cancers, among others.

  9. Distribution and significance of C40+ alkanes in the extracts of Cretaceous source rocks from the Songliao Basin

    Institute of Scientific and Technical Information of China (English)

    FENG; ZiHui; FANG; Wei; ZHANG; JuHe; LI; ZhenGuang; HUANG; ChunYan; WANG; Xue; ZHAO; QinLing; HUO; QiuLi

    2007-01-01

    Source rock extracts and crude oils from the Songliao Basin were analyzed by high-temperature gas chromatography (HTGC), gas chromatography-mass spectrometry (HTGC-MS) and gas chromatography-isotope ratio-mass spectrometry (GC-IRMS), for high molecular-weight alkanes. The distributions of n-alkanes in the Nenjiang Formation extracts are in the C14―C63 range; a bimodal distribution occurs in the and C21―40 regions. The C30―C37 n-alkanes are accompanied by C29―C35 hopanes, whereas the high molecular-weight C45―C47 n-alkanes co-occur with abundant isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The high δ13C values of the n-alkanes and the microscopic maceral compositions indicate a highly diversified organic source input for the Nenjiang Formation source rocks, ranging from aquatic plants, blue alge-bacteria, to land plant material. In contrast, n-alkanes in the rock extracts of the Qingshankou Formation are characterized by a single modal distribution, with relatively low abundances of C29―C35 hopanes, but high molecular-weight isoalkanes, alkylcyclohexanes and alkylcyclopentanes. The relatively low δ13C values of C22―C44 n-alkanes and organic material compositions indicate that the source rocks in the Qingshankou Formation contain dominantly type I algal organic matter. The relative abundance of compounds in source rocks changes little at low maturity stage, but decreases drastically at higher maturity levels, with a concurrent reduction in the odd/even carbon predominance. In crude oils, in contrast, the relative abundance of compounds appears to relate closely with the oil source and oil viscosity.

  10. Bougainvillea spectabilis Exhibits Antihyperglycemic and Antioxidant Activities in Experimental Diabetes.

    Science.gov (United States)

    Chauhan, Pratibha; Mahajan, Sunil; Kulshrestha, Archana; Shrivastava, Sadhana; Sharma, Bechan; Goswamy, H M; Prasad, G B K S

    2016-07-01

    The study investigates the effects of aqueous extract of Bougainvillea spectabilis leaves on blood glucose, glycosylated hemoglobin, lipid profile, oxidative stress, and on DNA damage, if any, as well as on liver and kidney functions in streptozotocin-induced diabetes in Wistar rats. Daily administration of the aqueous extract of B spectabilis leaves for 28 days resulted in significant reduction in hyperglycemia and hyperlipidemia as evident from restoration of relevant biochemical markers following extract administration. The extract also exhibited significant antioxidant activity as evidenced from the enzymatic and nonenzymatic responses and DNA damage markers. The extract restored kidney and liver functions to normal and proved to be nontoxic. A marked improvement in the histological changes of tissues was also observed. The present study documented antihyperglycemic, antihyperlipidemic, and antioxidative potentials of the aqueous extract of B spectabilis leaves without any toxicity in streptozotocin-treated Wistar rats.

  11. Parallel Exhibits: Combining Physical and Virtual Exhibits

    NARCIS (Netherlands)

    L. Lischke; T. Dingler; S. Schneegaß; A. Schmidt; M. van der Vaart; P. Wozniak

    2014-01-01

    People have a special fascination for original physical objects, their texture, and visible history. However, the digitization of exhibits and the use of these data is a current challenge for museums. We believe that museums need to capitalize on the affordances of physical exhibits to help users na

  12. Britain exhibition at CERN

    CERN Multimedia

    Bertin; CERN PhotoLab

    1969-01-01

    The United Kingdom inaugurated the Industrial Exhibitions in 1968, and it wasn't till 1971 that other countries staged exhibitions at CERN. This photo was taken in 1969, at the second British exhibition, where 16 companies were present.

  13. Anniversary Exhibition. Nechvolodov.

    Directory of Open Access Journals (Sweden)

    - -

    2006-03-01

    Full Text Available On the 10th of August, 2005 in Tartu (the second biggest educational and cultural city in Estonia Stanislav Nechvolodov's exhibition was opened to show the 5-year cycle of his work, traditional for the author and his admirers. At the opening ceremony Nechvolodov said that the exhibition was the last one and appointed on his 70th anniversary.The architectural and building society in Irkutsk remembers Stanislav Nechvolodov as an architect working on dwelling and civil buildings in 1960-70s. Below are some extracts from the Estonian press.«Postimees» newspaper, December 1993. The interview «Expressionistic naturalist, conservative Nechvolodov» by journalist Eric Linnumyagi. He asks about all the details and describes the troubles experienced by Nechvolodov during the perestroika period in Estonia, for example: the Tartu University refused to install the sculpture of Socrat, the art school refused to engage him as an instructor, the sculpture of Socrat moved to Vrotzlav, Poland, and Nechvolodov moved to Poland to read lectures there.«Tartu» newspaper, November 2000. Mats Oun, artist, says in the article «Nechvolodov: a man of Renaissance»: «Nechvolodov works in Estonia, his works are placed in many local and foreign museums. Regardless some insignificant faults, he deserves a high estimation, and his manysided open exhibition can be an example for other artists. He is a man of Renaissance».

  14. ECONOMIC SIGNIFICANCE OF DESIGN, DEVELOPMENT, AND EXTRACTION OF BITUMEN FROM BITUMINOUS SAND AND HEAVY OIL IN NIGERIA

    OpenAIRE

    Nwizug-bee L. K.

    2016-01-01

    Nigeria has the largest oil sands and bitumen resources in Africa and is one of the main leading countries in the world from the point of view of its significant potential heavy oil deposits. Research of geological and physicochemical properties confirmed that the Nigerian bitumen is an important energy source and an alternative source of hydrocarbon feedstock for the petrochemical industry. Nigeria imports black oil for the petrochemical industry and its heavy oil can act in place of this bl...

  15. ECONOMIC SIGNIFICANCE OF DESIGN, DEVELOPMENT, AND EXTRACTION OF BITUMEN FROM BITUMINOUS SAND AND HEAVY OIL IN NIGERIA

    Directory of Open Access Journals (Sweden)

    Nwizug-bee L. K.

    2016-09-01

    Full Text Available Nigeria has the largest oil sands and bitumen resources in Africa and is one of the main leading countries in the world from the point of view of its significant potential heavy oil deposits. Research of geological and physicochemical properties confirmed that the Nigerian bitumen is an important energy source and an alternative source of hydrocarbon feedstock for the petrochemical industry. Nigeria imports black oil for the petrochemical industry and its heavy oil can act in place of this black oil. In addition, researchers have successfully established the possibility of producing electrical energy from this heavy oil. Tar sands and bitumen are able to help improve the economy of Nigeria

  16. Digital collections and exhibits

    CERN Document Server

    Denzer, Juan

    2015-01-01

    Today's libraries are taking advantage of cutting-edge technologies such as flat panel displays using touch, sound, and hands-free motions to design amazing exhibits using everything from simple computer hardware to advanced technologies such as the Microsoft Kinect. Libraries of all types are striving to add new interactive experiences for their patrons through exciting digital exhibits, both online and off. Digital Collections and Exhibits takes away the mystery of designing stunning digital exhibits to spotlight library trea

  17. Small non-polar complexes exhibiting significant piezoelectric properties: Solvothermal synthesis and crystal structures of MO5V(tren)·H2O (M=Mo and W; tren=tris(2-aminoethyl)amine)

    Science.gov (United States)

    Rasmussen, M.; Näther, C.; Bismayer, U.; Bensch, W.

    2012-11-01

    The two isostructural complexes MO5V(tren)·H2O (M=Mo (1) and W (2)) were synthesized under solvothermal conditions at pH≈12 crystallizing in the non-centrosymmetric space group P212121. The structures are constructed by a distorted tetrahedral [MO4]2- anion bound via one shared oxygen atom to a severely distorted [VIVN4O]2+ complex completing the octahedral coordination around the V centre. The two O atoms in the VN4O2 octahedron are in cis position. The two compounds represent rare examples where the [MO4]2- anion is acting as a ligand. Both compounds exhibit a piezoelectric effect which is more pronounced for M=Mo. The samples are further characterized with IR and UV/Vis spectroscopy and thermal analysis.

  18. Small non-polar complexes exhibiting significant piezoelectric properties: Solvothermal synthesis and crystal structures of MO{sub 5}V(tren){center_dot}H{sub 2}O (M=Mo and W; tren=tris(2-aminoethyl)amine)

    Energy Technology Data Exchange (ETDEWEB)

    Rasmussen, M.; Naether, C. [Institut fuer Anorganische Chemie, Christian-Albrechts-Universitaet Kiel, Max-Eyth-Str. 2, D-24118 Kiel (Germany); Bismayer, U. [Mineralogisch-Petrographisches Institut, Universitaet Hamburg, Grindelallee 48 20146 Hamburg (Germany); Bensch, W., E-mail: wbensch@ac.uni-kiel.de [Institut fuer Anorganische Chemie, Christian-Albrechts-Universitaet Kiel, Max-Eyth-Str. 2, D-24118 Kiel (Germany)

    2012-11-15

    The two isostructural complexes MO{sub 5}V(tren){center_dot}H{sub 2}O (M=Mo (1) and W (2)) were synthesized under solvothermal conditions at pH Almost-Equal-To 12 crystallizing in the non-centrosymmetric space group P2{sub 1}2{sub 1}2{sub 1}. The structures are constructed by a distorted tetrahedral [MO{sub 4}]{sup 2-} anion bound via one shared oxygen atom to a severely distorted [V{sup IV}N{sub 4}O]{sup 2+} complex completing the octahedral coordination around the V centre. The two O atoms in the VN{sub 4}O{sub 2} octahedron are in cis position. The two compounds represent rare examples where the [MO{sub 4}]{sup 2-} anion is acting as a ligand. Both compounds exhibit a piezoelectric effect which is more pronounced for M=Mo. The samples are further characterized with IR and UV/Vis spectroscopy and thermal analysis. - Graphical abstract: The complexes [(V(tren)O)(MO4)]{center_dot}H2O (M = Mo, W; tren = tris(2-aminoethyl)amine)) composed of vertex-linked [MO4]{sup 2-} tetrahedron and [VN4O6]{sup 2+}octahedron. Highlights: Black-Right-Pointing-Pointer [MO{sub 4}]{sup 2-} tetrahedron (M=Mo, W) acting as ligand. Black-Right-Pointing-Pointer Jahn-Teller and steric distortion of the [VN{sub 4}O{sub 2}]{sup 2+} octahedron. Black-Right-Pointing-Pointer Non-centrosymmetric complexes exhibiting pronounced piezoelectric effect.

  19. Etruscan Culture Exhibition

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    EARLY this year an exhibition on the ancient civilization of Etruria was held at the Beijing-based China Millennium Monument.The theme of the exhibition was Etruscan Culture and on show were the most representative cultural and historical relics of this ancient civilization unearthed in the past 20 years. The 349 exhibits from various

  20. Ethics on Exhibit

    Science.gov (United States)

    Vick, Randy M.

    2011-01-01

    This article discusses ethical questions raised by an exhibition of work by an artist with a history of mental illness and the exhibition's relevance to art therapy and “outsider art” discourse on the subject. Considerations for how such an exhibit could be handled had the circumstances included an art therapist and art therapy client are…

  1. Chemical Composition of the Essential Oil and Diethyl Ether Extract of Trinia glauca (L.) Dumort. (Apiaceae) and the Chemotaxonomic Significance of 5-O-Methylvisamminol.

    Science.gov (United States)

    Radulović, Niko S; Đorđević, Miljana R; Dekić, Milan S; Blagojević, Polina D

    2016-04-01

    Analyses by GC, GC/MS, and NMR spectroscopy (1D- and 2D-experiments) of the essential oil and Et2O extract of Trinia glauca (L.) Dumort. (Apiaceae) aerial parts allowed a successful identification of 220 constituents, in total. The major identified compounds of the essential oil were (Z)-falcarinol (10.6%), bicyclogermacrene (8.0%), germacrene D (7.4%), δ-cadinene (4.3%), and β-caryophyllene (3.2%), whereas (Z)-falcarinol (47.2%), nonacosane (7.4%), and 5-O-methylvisamminol (4.0%) were the dominant constituents of the extract of T. glauca. One significant difference between the compositions of the herein and the previously analyzed T. glauca essential oils (only two reports) was noted. (Z)-Falcarinol was the major constituent in our case, whereas germacrene D (14.4 and 19.6%) was the major component of the previously studied oils. Possible explanations for this discrepancy were discussed. 5-O-Methylvisamminol, a (furo)chromone identified in the extract of T. glauca, has a limited occurrence in the plant kingdom and is a possible excellent chemotaxonomic marker (family and/or subfamily level) for Apiaceae.

  2. Exhibiting Mozart: Rethinking Biography

    OpenAIRE

    Spring, Ulrike

    2010-01-01

    Abstract: The article analyses the new permanent exhibition in the composer Wolfgang A. Mozart’s apartment in Vienna, opened in 2006, from the curator’s perspective. The exhibition presents an approach to biographical display in which the exhibited person becomes part of a multifaceted web of contexts, and the article argues for the active deployment of the polysemic character of objects as a means of grasping the complexity of a person’s biography. Presenting a concept for the...

  3. Healthy sheep that differ in scrapie associated PRNP genotypes exhibit significant differences of expression pattern associated with immune response and cell-to-cell signalling in retropharyngeal lymph nodes.

    Science.gov (United States)

    Komolka, Katrin; Ponsuksili, Siriluck; Schwerin, Manfred

    2013-04-15

    The present study was conducted to test the hypothesis whether prion protein gene (PRNP) associated scrapie susceptibility is connected with physiological changes in tissue involved in pathogen uptake, migration and propagation. Jejunum, ileal Peyer's patches, retropharyngeal lymph nodes, brain stem and liver of healthy and non scrapie-infected sheep with PRNP genotypes representing the scrapie risk class R1 (scrapie-resistant) and R5 (scrapie-susceptible), respectively, were comparatively analysed by microarray technology and quantitative reverse transcriptase polymerase chain reaction (RT qPCR). Significantly higher expression levels of genes involved in immune response and cell communication pathways in retropharyngeal lymph nodes of R1 sheep in comparison with R5 animals strongly suggest PRNP associated physiological processes with impact as an early barrier in pathogen defence. Equal expression patterns in brain stem suggest no physiological differences in brain of healthy R1 and R5 animals. In addition, similar expression pattern in liver indicates that there are no transcriptional differences in genes of the hepatic energy metabolism between animals of scrapie classes R1 and R5.

  4. A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts

    Science.gov (United States)

    Brown, Mark; Maawy, Ali; Chang, Alexander; Lee, Jacqueline; Gharibi, Armen; Katz, Matthew H; Fleming, Jason; Hoffman, Robert M; Bouvet, Michael; Doebler, Robert; Kelber, Jonathan A

    2017-01-01

    Next-generation sequencing (NGS) can identify and validate new biomarkers of cancer onset, progression and therapy resistance. Substantial archives of formalin-fixed, paraffin-embedded (FFPE) cancer samples from patients represent a rich resource for linking molecular signatures to clinical data. However, performing NGS on FFPE samples is limited by poor RNA purification methods. To address this hurdle, we developed an improved methodology for extracting high-quality RNA from FFPE samples. By briefly integrating a newly-designed micro-homogenizing (mH) tool with commercially available FFPE RNA extraction protocols, RNA recovery is increased by approximately 3-fold while maintaining standard A260/A280 ratios and RNA quality index (RQI) values. Furthermore, we demonstrate that the mH-purified FFPE RNAs are longer and of higher integrity. Previous studies have suggested that pancreatic ductal adenocarcinoma (PDAC) gene expression signatures vary significantly under in vitro versus in vivo and in vivo subcutaneous versus orthotopic conditions. By using our improved mH-based method, we were able to preserve established expression patterns of KRas-dependency genes within these three unique microenvironments. Finally, expression analysis of novel biomarkers in KRas mutant PDAC samples revealed that PEAK1 decreases and MST1R increases by over 100-fold in orthotopic versus subcutaneous microenvironments. Interestingly, however, only PEAK1 levels remain elevated in orthotopically grown KRas wild-type PDAC cells. These results demonstrate the critical nature of the orthotopic tumor microenvironment when evaluating the clinical relevance of new biomarkers in cells or patient-derived samples. Furthermore, this new mH-based FFPE RNA extraction method has the potential to enhance and expand future FFPE-RNA-NGS cancer biomarker studies. PMID:27602776

  5. Comparison of Essential Oils Obtained from Different Extraction Techniques as an Aid in Identifying Aroma Significant Compounds of Nutmeg (Myristica fragrans).

    Science.gov (United States)

    Chatterjee, Suchandra; Gupta, Sumit; Variyar, S Prasad

    2015-08-01

    Distribution of volatile constituents in the essential oil of nutmeg obtained by simultaneous distillation extraction (SDE), high vacuum distillation (HVD) and super critical fluid extraction (SFE) was compared with reduced pressure distillation (RPD) and head space (HS) analysis. HS and RPD volatiles were characterized by a high content of sabinene, followed by α-pinene and β-pinene. Interestingly, unlike the SDE, HVD and SFE oils, distillates from HS and RPD were marked by the absence of phenolic ethers namely myristicin, elemicin and safrole. The HS and RPD volatiles possessed a pleasant nutmeg aroma indicating a significant role of terpenic constituents in contributing to the top aroma note. GC-olfactometry (GC-O) of the oils aided in establishing the role of sabinene, α-pinene and β-pinene in contributing to the distinctive note of the spice. A high odor activity value (OAV) of sabinene and α-pinene established the role of these two constituents in imparting the characteristic nutmeg odor.

  6. Test Control Center exhibit

    Science.gov (United States)

    2000-01-01

    Have you ever wondered how the engineers at John C. Stennis Space Center in Hancock County, Miss., test fire a Space Shuttle Main Engine? The Test Control Center exhibit at StenniSphere can answer your questions by simulating the test firing of a Space Shuttle Main Engine. A recreation of one of NASA's test control centers, the exhibit explains and portrays the 'shake, rattle and roar' that happens during a real test firing.

  7. Zinc absorption from composite meals. I. The significance of whest extraction rate, zinc, calcium, and protein content in meals based on bread.

    Science.gov (United States)

    Sandström, B; Arvidsson, B; Cederblad, A; Björn-Rasmussen, E

    1980-04-01

    The absorption of zinc in man from composite meals based on bread was measured with a radionuclide technique using 65Zn and whole-body counting. Bread was made up from wheat flour of 100 and 72% extraction rate. A lower absolute amount of zinc was absorbed from the white bread compared to the absorption from the same amount of wholemeal bread. When the two types of bread were enriched with zinc chloride the absorption was higher from the white bread than from the wholemeal bread. Addition of calcium in the form of milk products improved the absorption of zinc from a meal with wholemeal bread. A significant positive correlation was found between zinc absorption and the protein content in meals containing milk, cheese, beef, and egg in various combinations with the wholemeal bread.

  8. Citrus ichangensis Peel Extract Exhibits Anti-Metabolic Disorder Effects by the Inhibition of PPARγ and LXR Signaling in High-Fat Diet-Induced C57BL/6 Mouse

    Directory of Open Access Journals (Sweden)

    Xiaobo Ding

    2012-01-01

    Full Text Available Obesity is a common nutritional disorder associated with type 2 diabetes, cardiovascular diseases, dyslipidemia, and certain cancers. In this study, we investigated the effects of Citrus ichangensis peel extract (CIE in high-fat (HF diet-induced obesity mice. Female C57BL/6 mice were fed a chow diet or an HF diet alone or supplemented with 1% w/w CIE for 8 weeks. We found that CIE treatment could lower blood glucose level and improve glucose tolerance. In the HF+CIE group, body weight gain, serum total cholesterol (TC and low-density lipoprotein cholesterol (LDL-c levels, and liver triglyceride (TG and TC concentrations were significantly (P<0.05 decreased relative to those in the HF group. To elucidate the mechanism of CIE on the metabolism of glucose and lipid, related genes expression in liver were examined. In liver tissue, CIE significantly decreased the mRNA expression levels of peroxisome proliferator-activated receptor γ (PPARγ and its target genes, such as fatty acid synthase (FAS and acyl-CoA oxidase (ACO. Moreover, CIE also decreased the expression of liver X receptor (LXR α and β which are involved in lipid and glucose metabolism. These results suggest that CIE administration could alleviate obesity and related metabolic disorders in HF diet-induced obesity mice through the inhibition of PPARγ and LXR signaling.

  9. 76 FR 52378 - Culturally Significant Objects Imported for Exhibition

    Science.gov (United States)

    2011-08-22

    ... Featuring Selections From the National Museum of History, Taiwan and the Arthur M. Sackler Gallery... Jade Featuring Selections from the National Museum of History, Taiwan and the Arthur M. Sackler Gallery... Art, San Antonio, TX, from on or about October 1, 2011, until on or about February 19, 2012, and...

  10. EXHIBITION: Accelerated Particles

    CERN Multimedia

    2004-01-01

    An exhibition of plastic arts and two evenings of performances by sound and visual artists as part of CERN's 50th anniversary celebrations. Fifty candles for CERN, an international laboratory renowned for fundamental research, is a cause for celebration. Since March this year, Geneva and neighbouring parts of France have been the venues for a wealth of small and large-scale events, which will continue until November. Given CERN's location in the commune of Meyrin, the ForuMeyrin is hosting exhibitions of plastic arts and performances entitled: Accelerated Particles. Several works will be exhibited and performed in two 'salons'. Salon des matières: An exhibition of plastic arts From Tues 12 October to Wed 3 November 2004 Tuesdays to Fridays: 16:00 to 19:00 Saturdays: 14:00 to 18:00 Exhibition open late on performance nights, entrance free Salon des particules: Musical and visual performances Tues 12 and Mon 25 October from 20:00 to 23:00 Preview evening for both events: Tues 12 October from 18:...

  11. Council Chamber exhibition

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    To complete the revamp of CERN’s Council Chamber, a new exhibition is being installed just in time for the June Council meetings.   Panels will showcase highlights of CERN’s history, using some of the content prepared for the exhibitions marking 50 years of the PS, which were displayed in the main building last November. The previous photo exhibition in the Council Chamber stopped at the 1970s. To avoid the new panels becoming quickly out of date, photos are grouped together around specific infrastructures, rather than following a classic time-line. “We have put the focus on the accelerators – the world-class facilities that CERN has been offering researchers over the years, from the well-known large colliders to the lesser-known smaller facilities,” says Emma Sanders, who worked on the content. The new exhibition will be featured in a future issue of the Bulletin with photos and an interview with Fabienne Marcastel, designer of the exhibit...

  12. 基于视觉显著性的人脸文字区域提取%Regional Extraction of Human Faces and Text Based on Visual Significant

    Institute of Scientific and Technical Information of China (English)

    何贵阳

    2014-01-01

    Based on the Matlab image text region detection method,a new method combining graphic separation and signifi-cant operation was proposed.Further significant fusion about traditional face text area detection results was realized based on visual significant face text region extraction demonstration system.The experimental results show that the proposed solution has higher recall ratio and precision.%基于Matlab 图像文字区域检测新方法对图文进行分离和显著性操作,并采用显著性度量对传统人脸文字区域检测的结果做进一步的显著性融合,实现了基于视觉显著性的人脸文字区域提取。实验结果表明,这种基于视觉显著性的人脸文字区域提取解决方案具有比较高的查全率和精确度。

  13. Exhibition in Sight

    Science.gov (United States)

    Wasserman, Burton

    1978-01-01

    Ludwig Mies van der Rohe is known primarily as an architect. However, he also designed chairs and tables. Discusses an exhibit held in New York City a few months ago which showed how well the famous architect achieved his goals in the area of furniture design. (Author/RK)

  14. Exhibitions in Sight

    Science.gov (United States)

    Wasserman, Burton

    1977-01-01

    Today, few artists make serving vessels on a monumental scale. Here artists compete in this unique area of specialization prompted by the Campbell Museum in Camden, New Jersey, which is dedicated to collecting and exhibiting the very best in soup tureens. (Author/RK)

  15. EXHIBITION: Accelerated Particles

    CERN Multimedia

    2004-01-01

    http://www.cern.ch/cern50/ An exhibition of plastic arts and two evenings of performances by sound and visual artists as part of CERN's fiftieth anniversary celebrations. The fiftieth anniversary of a world famous organization like CERN, an international laboratory specializing in fundamental research, is a cause for celebration. Since March this year, Geneva and neighbouring parts of France have been the venues for a wealth of small and large-scale events, which will continue until November. Given CERN's location in the commune of Meyrin, the ForuMeyrin is hosting two "salons" consisting of an exhibition of plastic arts and evenings of music and visual arts performances with the collective title of "Accelerated Particles". Several works will be exhibited and performed. Salon des matières: An exhibition of plastic arts Until Wednesday 3 November 2004. Tuesdays to Fridays: 4.00 p.m. to 7.00 p.m. Saturdays: 2.00 p.m. to 6.00 p.m. Doors open late on the evening of the performances. Salon des ...

  16. ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice.

    Science.gov (United States)

    Kang, So Young; Lee, Ki Yong; Koo, Kyung Ah; Yoon, Jeong Seon; Lim, Song Won; Kim, Young Choong; Sung, Sang Hyun

    2005-02-25

    We assessed the effects of oral treatments of ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, on learning and memory deficit. The cognition-enhancing effect of ESP-102 was investigated in scopolamine-induced (1 mg/kg body weight, s.c.) amnesic mice with both passive avoidance and Morris water maze performance tests. Acute oral treatment (single administration prior to scopolamine treatment) of mice with ESP-102 (doses in the range of 10 to 100 mg/kg body weight) significantly reduced scopolamine-induced memory deficits in the passive avoidance performance test. Another noteworthy result included the fact that prolonged oral daily treatments of mice with much lower amounts of ESP-102 (1 and 10 mg/kg body weight) for ten days reversed scopolamine-induced memory deficits. In the Morris water maze performance test, both acute and prolonged oral treatments with ESP-102 (single administration of 100 mg/kg body weight or prolonged daily administration of 1 and 10 mg/kg body weight for ten days, respectively, significantly ameliorated scopolamine-induced memory deficits as indicated by the formation of long-term and/or short-term spatial memory. In addition, we investigated the effects of ESP-102 on neurotoxicity induced by amyloid-beta peptide (Abeta25-35) or glutamate in primary cultured cortical neurons of rats. Pretreatment of cultures with ESP-102 (0.001, 0.01 and 0.1 mug/ml) significantly protected neurons from neurotoxicity induced by either glutamate or Abeta25-35. These results suggest that ESP-102 may have some protective characteristics against neuronal cell death and cognitive impairments often observed in Alzheimer's disease, stroke, ischemic injury and other neurodegenerative diseases.

  17. CERN permanent exhibitions

    CERN Multimedia

    2016-01-01

    Explore by yourself the issues CERN's physicists are trying to solve: given that the entire universe is made of particles, where do they come from? Why do they behave in the way they do? Discover the massive apparatus used by physicists at CERN, like the LHC, and see how each part works. And if you have more time on site, follow the LHC circuit at ground level to understand in situ this giant machine. Enter our exhibitions. Welcome!

  18. Droplet Lamp Design exhibition

    OpenAIRE

    Unver, Ertu; Dean, Lionel Theodore

    2011-01-01

    This paper describes experiments in the use of digital fluid simulation techniques within a\\ud product design context. It discusses the adoption and adaptation of virtual modelling tools in\\ud 3D creative practice. This work is exhibited at EuroMold, the world-wide fair in Germany for\\ud mold making, tooling, design and application development with around 60.000 visitors and lasts\\ud 4 days. The fair brings together professionals from design, prototyping and manufacturing.

  19. Upcycling CERN Exhibitions

    CERN Multimedia

    Katarina Anthony

    2015-01-01

    Summer is coming - and with it, a new Microcosm exhibition showcasing CERN (see here). But while the new exhibit is preparing to enchant visitors, many have been asking about the site's former content. Will it simply be out with the old and in with the new? Not as such!   The plasma ball from Microcosm is now on display at the LHCb site. As Microcosm's new content is moving in, its old content is moving up. From LHCb to IdeaSquare, former Microcosm displays and objects are being installed across the CERN site. "Microcosm featured many elements that were well suited to life outside of the exhibition," says Emma Sanders, Microcosm project leader in the EDU group. "We didn't want this popular content to go to waste, and so set out to find them new homes across CERN." The LHCb experiment has received a number of Microcosm favourites, including the Rutherford experiment, the cosmic ray display and the Thomson experiment. "We&...

  20. Online Exhibits & Concept Maps

    Science.gov (United States)

    Douma, M.

    2009-12-01

    Presenting the complexity of geosciences to the public via the Internet poses a number of challenges. For example, utilizing various - and sometimes redundant - Web 2.0 tools can quickly devour limited time. Do you tweet? Do you write press releases? Do you create an exhibit or concept map? The presentation will provide participants with a context for utilizing Web 2.0 tools by briefly highlighting methods of online scientific communication across several dimensions. It will address issues of: * breadth and depth (e.g. from narrow topics to well-rounded views), * presentation methods (e.g. from text to multimedia, from momentary to enduring), * sources and audiences (e.g. for experts or for the public, content developed by producers to that developed by users), * content display (e.g. from linear to non-linear, from instructive to entertaining), * barriers to entry (e.g. from an incumbent advantage to neophyte accessible, from amateur to professional), * cost and reach (e.g. from cheap to expensive), and * impact (e.g. the amount learned, from anonymity to brand awareness). Against this backdrop, the presentation will provide an overview of two methods of online information dissemination, exhibits and concept maps, using the WebExhibits online museum (www.webexhibits.org) and SpicyNodes information visualization tool (www.spicynodes.org) as examples, with tips on how geoscientists can use either to communicate their science. Richly interactive online exhibits can serve to engage a large audience, appeal to visitors with multiple learning styles, prompt exploration and discovery, and present a topic’s breadth and depth. WebExhibits, which was among the first online museums, delivers interactive information, virtual experiments, and hands-on activities to the public. While large, multidisciplinary exhibits on topics like “Color Vision and Art” or “Calendars Through the Ages” require teams of scholars, user interface experts, professional writers and editors

  1. Chronic administration of ethanol leaf extract of Moringa oleifera Lam. (Moringaceae) may compromise glycaemic efficacy of Sitagliptin with no significant effect in retinopathy in a diabetic rat model.

    Science.gov (United States)

    Olurishe, Comfort; Kwanashie, Helen; Zezi, Abdulkadiri; Danjuma, Nuhu; Mohammed, Bisalla

    2016-12-24

    Moringa oleifera Lam. (Moringaceae) has gained awareness for its antidiabetic effect, and is used as alternative therapy or concurrently with orthodox medicines such as sitagliptin in diabetes mellitus. This is without ascertaining the possibility of drug-herb interactions, which could either lead to enhanced antidiabetic efficacy, increased toxicity, or compromised glycaemic control with negative consequence in diabetic retinopathy. To investigate the effect, of sitagliptin (50mg/kg), Moringa oleifera (300mg/kg) leaf extract, and a combination of both on glycaemic control parameters, lenticular opacity and changes in retinal microvasculature in alloxan (150mg/kg i.p) induced diabetic rat model. Seven groups of eight rats per group were used, with groups I, II and VII as normal (NC), diabetic (DC) and post-prandial controls (PPC). Groups III to VI were diabetic rats on sitagliptin (III), M. oleifera (IV), sitagliptin and M. oleifera (SM) (V), for 42 days with 2 weeks delayed treatment in a post-prandial hyperglycaemic group (PPSM) (VI). Glycaemic control parameters, insulin levels, body weights, and effects of retinal microvasculature on lenticular opacity/morphology were investigated. A significant decrease in fasting blood glucose (FBG) levels was displayed in SM group from day 14(60%) (poleifera showed a progressive decrease in anti-hyperglycaemic effect of sitagliptin, and although it delayed the onset of lenticular opacity (i.e. cataract-like changes) it did not prevent the progression nor ameliorated pathologic lesions in the retina. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  2. Space Shuttle Cockpit exhibit

    Science.gov (United States)

    2000-01-01

    Want to sit in the cockpit of the Space Shuttle and watch astronauts work in outer space? At StenniSphere, you can do that and much more. StenniSphere, the visitor center at John C. Stennis Space Center in Hancock County, Miss., presents 14,000-square-feet of interactive exhibits that depict America's race for space as well as a glimpse of the future. StenniSphere is open free of charge from 9 a.m. to 5 p.m. daily.

  3. World Expo and Exhibition Industry

    Institute of Scientific and Technical Information of China (English)

    Guo Liqin

    2010-01-01

    @@ February 8 witnessed the construction of 2010 World Expo's China Pavilion completed after two years' work. The pavilion, in the shape of an oriental crown,showcases the spirit of traditional Chinese culture. It is significant since all other nation's pavilion constructed only for temporary exhibition, but China's Pavilion will be lasting architecture as the symbol of world civilization. Another similar famous case is Eiffel Tower which was built as the entrance of the world expo held in. 1889.

  4. Crude extracts of marine-derived and soil fungi of the genus Neosartorya exhibit selective anticancer activity by inducing cell death in colon, breast and skin cancer cell lines

    Directory of Open Access Journals (Sweden)

    Alice Abreu Ramos

    2016-01-01

    Full Text Available Background: The crude ethyl acetate extracts of marine-derived fungi Neosartorya tsunodae KUFC 9213 (E1 and N. laciniosa KUFC 7896 (E2, and soil fungus N. fischeri KUFC 6344 (E3 were evaluated for their in vitro anticancer activities on a panel of seven human cancer cell lines. Materials and Methods: The 3-(4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide assay was performed, after 48 h treatments with different concentrations of extracts, to determine their concentration of the extract or Dox that inhibits cell viability by 50% for each cell line. The effects of the crude extracts on DNA damage, clonogenic potential and their ability to induce cell death were also assessed. Results: E1 was found to the void of anti-proliferative effects. E2 was shown to decrease the clonogenic potential in human colorectal carcinoma cell line (HCT116, human malignant melanoma cell line (A375, human breast adenocarcinoma cell line (MCF7, and human caucasian colon adenocarcinoma Grade II cell line (HT29 cells, whereas E3 showed such effect only in HCT116 and MCF7 cells. Both extracts were found to increase DNA damage in some cell lines. E2 was found to induce cell death in HT29, HCT116, MCF7, and A375 cells while extract E3 increased cell death in MCF7 and HCT116 cell lines. Conclusion: The results reveal that E2 and E3 possess anticancer activities in human colon carcinoma, breast adenocarcinoma, and melanoma cells, validating the interest for an identification of molecular targets involved in the anticancer activity.

  5. Crude Extracts of Marine-derived and Soil Fungi of the Genus Neosartorya Exhibit Selective Anticancer Activity by Inducing Cell Death in Colon, Breast and Skin Cancer Cell Lines

    OpenAIRE

    Alice Abreu Ramos; Bruno Castro-Carvalho; Maria Prata-Sena; Tida Dethoup; Suradet Buttachon; Anake Kijjoa; Eduardo Rocha

    2016-01-01

    Background: The crude ethyl acetate extracts of marine-derived fungi Neosartorya tsunodae KUFC 9213 (E1) and N. laciniosa KUFC 7896 (E2), and soil fungus N. fischeri KUFC 6344 (E3) were evaluated for their in vitro anticancer activities on a panel of seven human cancer cell lines. Materials and Methods: The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed, after 48 h treatments with different concentrations of extracts, to determine their concentration of the e...

  6. No significant effect of ginkgo biloba special extract EGb 761 in the treatment of primary Raynaud phenomenon: a randomized controlled trial.

    NARCIS (Netherlands)

    Bredie, S.J.H.; Jong, M.C.J. de

    2012-01-01

    BACKGROUND: Medicinal treatment of vasospastic Raynaud phenomenon is limited to primarily vasodilator medicines. OBJECTIVE: To explore the possible beneficial effects and tolerability of 120 mg two times a day of Ginkgo Biloba special extract EGb 761 in patients suffering from Raynaud disease (RD) (

  7. 2007Fairs & Exhibitions in China

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ The 6th China (Guangzhou) International Seasoning Exhibition Date: May 11-13 Founded in: 2003.05 Venues: Guangzhou Int'l Convention &Exhibition Center (Pazhou) Exhibits: Seasonings, food additives, relevant material,equipment, service and publications

  8. 2005 Fairs & Exhibitions in China

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ Harbin China International Winter Goods Exhibition DATE: Jan. 5-9 FREQUENCY: Annual FOUNDED TIME: Dec. 2001 VENUE: Harbin China International Conference & Exhibition Center EXHIBITS: winter sports goods and outdoor devices

  9. Arsenic Speciation and Extraction and the Significance of Biodegradable Acid on Arsenic Removal—An Approach for Remediation of Arsenic-Contaminated Soil

    Directory of Open Access Journals (Sweden)

    Thinh Nguyen Van

    2017-08-01

    Full Text Available A series of arsenic remediation tests were conducted using a washing method with biodegradable organic acids, including oxalic, citric and ascorbic acids. Approximately 80% of the arsenic in one sample was removed under the effect of the ascorbic and oxalic acid combination, which was roughly twice higher than the effectiveness of the ascorbic and citric acid combination under the same conditions. The soils treated using biodegradable acids had low remaining concentrations of arsenic that are primarily contained in the crystalline iron oxides and organic matter fractions. The close correlation between extracted arsenic and extracted iron/aluminum suggested that arsenic was removed via the dissolution of Fe/Al oxides in soils. The fractionation of arsenic in four contaminated soils was investigated using a modified sequential extraction method. Regarding fractionation, we found that most of the soil contained high proportions of arsenic (As in exchangeable fractions with phosphorus, amorphous oxides, and crystalline iron oxides, while a small amount of the arsenic fraction was organic matter-bound. This study indicated that biodegradable organic acids can be considered as a means for arsenic-contaminated soil remediation.

  10. Arsenic Speciation and Extraction and the Significance of Biodegradable Acid on Arsenic Removal—An Approach for Remediation of Arsenic-Contaminated Soil

    Science.gov (United States)

    Nguyen Van, Thinh; Osanai, Yasuhito; Do Nguyen, Hai; Kurosawa, Kiyoshi

    2017-01-01

    A series of arsenic remediation tests were conducted using a washing method with biodegradable organic acids, including oxalic, citric and ascorbic acids. Approximately 80% of the arsenic in one sample was removed under the effect of the ascorbic and oxalic acid combination, which was roughly twice higher than the effectiveness of the ascorbic and citric acid combination under the same conditions. The soils treated using biodegradable acids had low remaining concentrations of arsenic that are primarily contained in the crystalline iron oxides and organic matter fractions. The close correlation between extracted arsenic and extracted iron/aluminum suggested that arsenic was removed via the dissolution of Fe/Al oxides in soils. The fractionation of arsenic in four contaminated soils was investigated using a modified sequential extraction method. Regarding fractionation, we found that most of the soil contained high proportions of arsenic (As) in exchangeable fractions with phosphorus, amorphous oxides, and crystalline iron oxides, while a small amount of the arsenic fraction was organic matter-bound. This study indicated that biodegradable organic acids can be considered as a means for arsenic-contaminated soil remediation.

  11. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Gaïa Manuella Cany Du 10 au 28 avril 2017 CERN Meyrin, Bâtiment principal Oiseau - Manuella Cany. Tableaux abstraits inspirés de vues satellites ou photos prises du ciel. Certains sont à la frontière du figuratif alors que d'autres permettent de laisser libre cours à son imagination. Aux détails infinis, ces tableaux sont faits pour être vus de loin et de près grâce à une attention toute particulière apportée aux effets de matières et aux couleurs le long de volutes tantôt nuancées tantôt contrastées.   Pour plus d’informations : staff.association@cern.ch | Tél: 022 766 37 38

  12. Exhibition

    CERN Multimedia

    Staff Association

    2014-01-01

      Parallels vision Astronomical subjects which evoke extrasensory kinetic visions Alberto Di Fabio From 8 to 10 October, CERN Meyrin, Main Building In the framework of Italy@cern, the Staff Association presents Alberto Di Fabio. Di Fabio’s work is inspired by the fundamental laws of the physical world, as well as organic elements and their interrelation. His paintings and works on paper merge the worlds of art and science, depicting natural forms and biological structures in vivid colour and imaginative detail. For all additional information: staff.association@cern.ch | Tel: 022 767 28 19

  13. Exhibition

    CERN Multimedia

    Staff Association

    2011-01-01

    Jan Hladky, physicien de l'Institut de Physique de l'Académie des Sciences de la République tchèque, et membre de la collaboration Alice, expose ses œuvres au Bâtiment principal du 20 avril au 6 mai. Son exposition est dédiée aux victimes du séisme de Sendai. Des copies de ses œuvres seront mises en vente et les sommes récoltées seront versées au profit des victimes.

  14. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    The Elementary Particles of Painting Alfonso Fratteggiani Bianchi and Ermanno Imbergamo From September 26 to October 7, 2016 CERN Meyrin, Main Building With intentions similar to those of CERN physicists, the artist Alfonso Fratteggiani Bianchi investigates the color pigment, studying its interaction with light and with the support on which it is deposited. He creates monochrome paintings by spreading the color pigment in the pure state on stones, without using glue or any other type of adhesive. With intentions similar to artists, the physicist Ermanno Imbergamo investigates the use of luminescent wavelength shifters, materials commonly used in Particle Physics, for art. He creates other monochrome artworks, which disclose further aspects of interaction among light, color pigments and support. For more information: staff.association@cern.ch | Tel: 022 767 28 19

  15. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    La mosaïque ou quand détruire permet de construire Lauren Decamps Du 28 novembre au 9 décembre 2016 CERN Meyrin, Bâtiment principal Paysage d'Amsterdam - Lauren Decamps On ne doit jamais rien détruire qu'on ne soit sûr de pouvoir remplacer aussi avantageusement " écrivait Plutarque dans ses Œuvres morales du 1er siècle après JC. L'artiste mosaïste Lauren Decamps adhère à cette idée et tente à sa manière de donner une nouvelle vie à ses matériaux en les taillant puis les réassemblant, créant ainsi des œuvres abstraites et figuratives.

  16. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Le Point Isabelle Gailland Du 20 février au 3 mars 2017 CERN Meyrin, Bâtiment principal La Diagonale - Isabelle Gailland. Au départ, un toujours même point minuscule posé au centre de ce que la toile est un espace. Une réplique d'autres points, condensés, alignés, isolés, disséminés construiront dans leur extension, la ligne. Ces lignes, croisées, courbées, déviées, prolongées, seront la structure contenant et séparant la matière des couleurs. La rotation de chaque toile en cours d'exécution va offrir un accès illimité à la non-forme et à la forme. Le point final sera l'ouverture sur différents points de vue de ce que le point et la ligne sont devenus une représentation pour l'œil et l'im...

  17. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    COLORATION Sandra Duchêne From September 5 to 16, 2016 CERN Meyrin, Main Building La recherche de l’Universel. Après tout ! C’est de l’Amour ! What else to say ? …La couleur, l’ENERGIE de la vie…

  18. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Œuvres recentes Fabienne Wyler Du 6 au 17 février 2017 CERN Meyrin, Bâtiment principal L'escalier du diable B - aquarelle, encre de Chine XLV - Fabienne Wyler. En relation avec certains procédés d’écriture contemporaine (par ex. Webern ou certaines musiques conçues par ordinateur), les compositions picturales de Fabienne Wyler s’élaborent à partir de « modules » (groupes de quadrangles) qu’elle reproduit en leur faisant subir toutes sortes de transformations et de déplacements : étirements, renversements, rotations, effet miroir, transpositions, déphasages, superpositions, etc., et ceci à toutes les échelles. Au fil des œuvres sont apparues des séries intitulées, Bifurcations, Intermittences, Attracteurs étranges, Polyrythmies. Ces titres ont un lien &e...

  19. Exhibition

    CERN Multimedia

    Staff Association

    2014-01-01

    Energie sombre, matière noire J.-J. Dalmais - J. Maréchal Du 11 au 27 novembre 2014, CERN Meyrin, Bâtiment principal A l’image des particules atomiques qui ont tissé des liens pour créer la matière, deux artistes haut bugistes croisent leurs regards et conjuguent leurs expressions singulières pour faire naître une vision commune de l’univers, produit des forces primordiales. Les sculptures de Jean-Jacques Dalmais et les peintures de Jacki Maréchal se rencontrent pour la première fois et se racontent par un enrichissement mutuel la belle histoire de la Vie. Dialogue magique des œuvres en mouvement qui questionnent en écho l’énergie sombre et la matière noire. Cette harmonieuse confluence de jeux de miroir et de résonnance illumine de poésie et de sobriété l’espace expos&...

  20. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Harmonie Nathalie Lenoir Du 4 au 15 septembre 2017 CERN Meyrin, Bâtiment principal Peindre est un langage. Le tracé du pinceau sur le lin en est l'expression. A qui appartient un tableau en définitive ? A celui qui l'a peint ? A celui qui le regarde ? A celui qui l'emporte ? La peinture est une émotion partagée... Laissez-vous projeter de l'autre côté de la toile, prenez un moment pour rêver, en harmonie avec les éléments, parce-que la peinture parle à votre âme… Pour plus d’informations et demandes d’accès : staff.association@cern.ch | Tél : 022 766 37 38

  1. Exhibition

    CERN Document Server

    Staff Association

    2017-01-01

    Firmament des toiles Joëlle Lalagüe Du 6 au 16 juin 2017 CERN Meyrin, Bâtiment principal Phylaë Voyage - Joëlle Lalagüe. Each picture is an invitation for a cosmic trip. This is a whispering of soul, which comes from origins. A symphony of the world, some notes of love, a harmony for us to fly to infinity. Pour plus d’informations et demandes d'accès : staff.association@cern.ch | Tél: 022 766 37 38

  2. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    La couleur des jours oriSio Du 2 au 12 mai 2017 CERN Meyrin, Bâtiment principal oriSio - Motus Suite à un fort intérêt pour la Chine et une curiosité pour un médium très ancien, la laque ! Je réinterprète cet art à travers un style abstrait. Je présente ici des laques sur aluminium, travaillés au plasma et ensuite colorés à l’aide de pigments pour l’essentiel. Mes œuvres je les veux brutes, déchirées, évanescentes, gondolées, voire trouées mais avec une belle approche de profondeur de la couleur.   Pour plus d’informations : staff.association@cern.ch | Tél: 022 766 37 38

  3. Exhibition

    CERN Multimedia

    Staff Association

    2016-01-01

    La mosaïque ou quand détruire permet de construire Lauren Decamps Du 28 novembre au 9 décembre 2016 CERN Meyrin, Bâtiment principal Paysage d'Amsterdam - Lauren Decamps On ne doit jamais rien détruire qu'on ne soit sûr de pouvoir remplacer aussi avantageusement " écrivait Plutarque dans ses Œuvres morales du 1er siècle après JC. L'artiste mosaïste Lauren Decamps adhère à cette idée et tente à sa manière de donner une nouvelle vie à ses matériaux en les taillant puis les réassemblant, créant ainsi des œuvres abstraites et figuratives.

  4. Exhibition

    CERN Multimedia

    Staff Association

    2017-01-01

    Still Life Jérémy Bajulaz Du 25 septembre au 6 octobre 2017 CERN Meyrin, Main Building (Aubergine - Jérémy Bajulaz) Né en 1991 en Haute-Savoie, France. Diplômé de l'Ecole Emile Cohl à Lyon, Jérémy Bajulaz intègre en 2014 le programme d'artiste en résidence au Centre Genevois de Gravure Contemporaine. C'est là que son travail prendra corps, autour de la lumière et de ses vibrations aux travers de sujets comme le portrait et la nature morte, dans le souci de l'observation; le regard prenant une place importante dans le processus créatif. Lauréat 2017 du VII Premio AAAC, son travail a été présenté dans de nombreuses expositions collectives, en 2015 au Bâtiment d’Art Contemporain de Genève, en 2016 au 89e Salon de Lyon et du S...

  5. The Gravity- Powered Calculator, a Galilean Exhibit

    Science.gov (United States)

    Cerreta, Pietro

    2014-04-01

    The Gravity-Powered Calculator is an exhibit of the Exploratorium in San Francisco. It is presented by its American creators as an amazing device that extracts the square roots of numbers, using only the force of gravity. But if you analyze his concept construction one can not help but recall the research of Galileo on falling bodies, the inclined plane and the projectile motion; exactly what the American creators did not put into prominence with their exhibit. Considering the equipment only for what it does, in my opinion, is very reductive compared to the historical roots of the Galilean mathematical physics contained therein. Moreover, if accurate deductions are contained in the famous study of S. Drake on the Galilean drawings and, in particular on Folio 167 v, the parabolic paths of the ball leaping from its launch pad after descending a slope really actualize Galileo's experiments. The exhibit therefore may be best known as a `Galilean calculator'.

  6. ANTIOXIDANT ACTIVITY, TOTAL PHENOLIC AND FLAVONOID CONTENT OF MORINDA CITRIFOLIA FRUIT EXTRACTS FROM VARIOUS EXTRACTION PROCESSES

    Directory of Open Access Journals (Sweden)

    PRAVEEN K. RAMAMOORTHY

    2007-04-01

    Full Text Available Soxhlet, Ultrasonic extract of Morinda citrifolia L. fruit and four extracts from high pressure extraction at 10 MPa using ethanol, ethyl acetate as solvent and dried by vacuum oven and spray dryer were analyzed for their antioxidant activity by peroxide value method and diphenylpicrylhydrazyl radical scavenging method. The five extracts along with the reference samples, butylated hydroxyl toluene and tannic acid were further analyzed to determine their total phenolic content by Folin-Ciocalteau method and total flavonoid content by Dowd method. The M. citrifolia extract by high pressure extraction with ethyl acetate as solvent and spray dried was found to exhibit highest antioxidant activity and total flavonoid content. High total phenolic content was determined in the high pressure extract using ethyl acetate as solvent and vacuum dried. It was interesting to note that ultrasonic extract exhibited significant antioxidant activity, total phenolic and flavonoid content. High pressure extracted M. citrifolia in ethanol was found to express lesser values comparatively. The significant difference in activity among the high pressure extracts was found to be due to the polarity of the solvents used for extraction as M. citrifolia fruit contains relatively larger quantity of non-polar antioxidant compounds. It was also found that the drying methods had significant impact on the antioxidant activity, total phenolic and flavonoid content of the extracts.

  7. Anthelmintic activity of ethanolic leaf extract of Jasminum mesnyi

    Directory of Open Access Journals (Sweden)

    Vibhuti Dullu

    2014-02-01

    Full Text Available Objective: To evaluate the anthelmintic activity of ethanolic extract of leaves of Jasminum mesnyi. Methods: Anthelmintic activity was carried out on adult Indian earthworm Eisenia fetida. In this study, 20 mg/mL and 40 mg/mL concentrations of plant extract were tested which involved the time of paralysis and time of death of worm. Albendazole (10 mg/mL was taken as reference standard drug whereas distilled water was used as control. Results: The extract exhibited significant anthelmintic acitivity which was more in higher concentration extract. Conclusions: It was concluded from the present study that the plant exhibited significant anthelmintic activity.

  8. The World of Virtual Exhibitions

    Directory of Open Access Journals (Sweden)

    Irena Eiselt

    2013-09-01

    Full Text Available EXTENDED ABSTRACTSpecial collections of the National and University Library (NUK hide a lot of items of precious value. The Slovenian cultural heritage is stored on paper or on other media as a part of the library’s Manuscripts, Incunabula and Rare Books Collection, Old Prints Collection, Maps and Pictorial Collection, Music Collection, Ephemera Collection, Serials Collection, and Slovenian Diaspora Publications Collection. Only a small part of the treasures is temporary revealed to the public on special exhibitions. The idea of virtual exhibitions of library treasures was born in 2005. The library aimed to exhibit precious items of special collections of high historical or artistic value. In 2008 the first two virtual exhibitions were created in-house offering access to the rich collections of old postcards of Ljubljana at the beginning of 20th century kept in the Maps and Pictorial Collection of NUK. They were soon followed by other virtual exhibitions. At the beginning they were organised in the same way as physical exhibitions, afterwards different programs were used for creation of special effects (for ex. 3D wall. About two years ago it was decided that the creation of virtual exhibitions will be simplified. Files of digitised and borndigital library materials in jpg format are imported to MS PowerPoint 2010. Each jpg file is now formatted by adding a frame, a description … to the slides which are saved as jpg files. The last step is the import of jpg files into Cooliris application used for NUK web exhibitions. In the paper the virtual exhibition design and creation, the technical point of view and criteria for the selection of exhibition content are explained following the example of the virtual exhibitions the Old Postcards of Ljubljana, Photo Ateliers in Slovenia, a collection of photographs Four Seasons by Fran Krašovec and photos of Post-Earthquake Ljubljana in 1895.

  9. [All-Russian hygienic exhibitions and museums].

    Science.gov (United States)

    Kuzybaeva, M P

    2011-01-01

    The material about the popularization of hygiene and health education in Russia in the second half of the 19th century to early 20th century through exhibition and museum activities has been collected for the first time and analyzed in the paper. The role of scientists and scientific medical societies in this process is noted. The significance of museum and exhibition activities in this area for the development of medical science is defined.

  10. Oil extract from Gongronema latifolium leaves exhibit anti-diabetic ...

    African Journals Online (AJOL)

    chi

    2013-11-06

    Nov 6, 2013 ... The F2 (oil) fraction was characterized by gas chromatography/mass ... Gongronema latifolium, essential fatty acids, diabetes mellitus, ulcer, prostaglandins. .... chromatography and on further concentration yielded fractions 1.

  11. Auto Technology Exhibition in Tianjing

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ The 4th International Automotive Technology Exhibition Tianjing2009,jointly hosted by the Society of Automotive Engineers of China(SAE-China),China Automotive Technology and Research Center(CATRC)and Tianjin Economic-Technological Development Area(TETD),is to be held in Tianjin Binhai International Convention and Exhibition Center from August 27 to August 30 this year.In line with China's national 11th Five-year Plan,The Automobile Industry Revitalization and Adjustments Planning and The Equipment Manufacturing Revitalization and Adjustments Planning,this Exhibition,centered on the theme of automobile and equipment manufacturing,arranges the exhibition halls respectively for private autos,commercial autos and equipment manufacturing etc.

  12. Photowalk Exhibition opens at Microcosm

    CERN Document Server

    Katarina Anthony

    2011-01-01

    The winning photographs from the 2010 Global Particle Physics Photowalk competition will go on display at Microcosm from 11 February to 2 April. The exhibition is part of a global photography event taking place over three continents, with Photowalk exhibitions opening simultaneously at Fermilab in the US, KEK in Japan and here at CERN.   DESY wire chamber - First place people's choice; second place global jury competition. Photographer: Hans-Peter Hildebrandt  If you were one of the 1,300 photography lovers who voted in last year’s Photowalk competition, this exhibition is your chance to see the winning entries in print. The exhibition will take place in the downstairs gallery of Microcosm, overlooking the garden. 15 photographs will be on display, with each of the laboratories that participated in Photowalk represented by their 3 winning entries. Among them will be the “people’s choice” sunburst photo of a particle detector at DESY (Photo 1), and...

  13. Globe exhibit wins international acclaim

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    The Globe’s “Universe of Particles” exhibition has recently received four prestigious awards for its avant-garde design. This external praise is great encouragement for the CERN exhibitions currently on the drawing board.   The Universe of Particles exhibition has won 4 awards for its avant-garde design. Back in 2008, the design company Atelier Brückner was presented with a challenge: to design the layout of a new permanent exhibition for CERN, one that would epitomize both the Organization and its research. The brief was concise but complex: the exhibit had to be symbolic of the Organization, use modern technology, engage and immerse visitors, and, preferably, use touch-screen technology. With the help of IArt, an interactive technology firm, and based on the content provided by CERN’s Education Group, Atelier Brückner developed the “Universe of Particles” exhibit as it is today. Its principal concept centred on the s...

  14. Greenhouse Earth: A Traveling Exhibition

    Energy Technology Data Exchange (ETDEWEB)

    Booth, W.H.; Caesar, S.

    1992-09-01

    The Franklin Institute Science Museum provided an exhibit entitled the Greenhouse Earth: A Traveling Exhibition. This 3500 square-foot exhibit on global climate change was developed in collaboration with the Association of Science-Technology Centers. The exhibit opened at The Franklin Institute on February 14, 1992, welcoming 291,000 visitors over its three-month stay. During its three-year tour, Greenhouse Earth will travel to ten US cities, reaching two million visitors. Greenhouse Earth aims to deepen public understanding of the scientific issues of global warming and the conservation measures that can be taken to slow its effects. The exhibit features hands-on exhibitry, interactive computer programs and videos, a theater production, a demonstration cart,'' guided tours, and lectures. supplemental educational programs at the Institute included a teachers preview, a symposium on climate change, and a satellite field trip.'' The development of Greenhouse Earth included front-end and formative evaluation procedures. Evaluation includes interviews with visitors, prototypes, and summative surveys for participating museums. During its stay in Philadelphia, Greenhouse Earth was covered by the local and national press, with reviews in print and broadcast media. Greenhouse Earth is the first large-scale museum exhibit to address global climate change.

  15. What's Worth Teaching? Extracting Significant Content.

    Science.gov (United States)

    Switzer, Thomas J.

    1980-01-01

    A model which secondary social studies teachers could apply to their content area suggests an interplay between the inductive and the deductive--where students first identify a proposition from an examination of evidence and then test the proposition to assess its power in helping students understand the complex nature of social reality.…

  16. Exhibition - Mathematics, A Beautiful Elsewhere

    CERN Multimedia

    2011-01-01

    From 21 October 2011 to 18 March 2012, the Fondation Cartier pour l’art contemporain will present the exhibition Mathematics: A Beautiful Elsewhere, an exhibition developed in association with the Institut des Hautes Études Scientifiques (IHÉS) and under the patronage of UNESCO. For this unprecedented event, the foundation invited mathematicians to work with artists with whom it has previously worked to create an exhibition that allows visitors to see, hear, do, interpret and think about mathematics. By bringing mathematics into its premises, the Fondation Cartier is itself undergoing the “sudden change of scenery” described by mathematician Alexandre Grothendieck. More information is available here. Fondation Cartier pour l’art contemporain 261, boulevard Raspail 75014 Paris http://fondation.cartier.com Private Visit For professors, researchers and all the staff of Mathematics departments...

  17. IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation

    Directory of Open Access Journals (Sweden)

    Mbofung Carl MF

    2009-03-01

    Full Text Available Abstract Background A recent in vitro study indicates that IGOB131, a novel seed extract of the traditional West African food plant Irvingia gabonensis, favorably impacts adipogenesis through a variety of critical metabolic pathways including PPAR gamma, leptin, adiponectin, and glycerol-3 phosphate dehydrogenase. This study was therefore aimed at evaluating the effects of IGOB131, an extract of Irvingia gabonensis, on body weight and associated metabolic parameters in overweight human volunteers. Methods The study participants comprised of 102 healthy, overweight and/or obese volunteers (defined as BMI > 25 kg/m2 randomly divided into two groups. The groups received on a daily basis, either 150 mg of IGOB131 or matching placebo in a double blinded fashion, 30–60 minutes before lunch and dinner. At baseline, 4, 8 and 10 weeks of the study, subjects were evaluated for changes in anthropometrics and metabolic parameters to include fasting lipids, blood glucose, C-reactive protein, adiponectin, and leptin. Results Significant improvements in body weight, body fat, and waist circumference as well as plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin and leptin levels were observed in the IGOB131 group compared with the placebo group. Conclusion Irvingia gabonensis administered 150 mg twice daily before meals to overweight and/or obese human volunteers favorably impacts body weight and a variety of parameters characteristic of the metabolic syndrome. This is the first double blind randomized placebo controlled clinical trial regarding the anti-obesity and lipid profile modulating effects of an Irvingia gabonensis extract. The positive clinical results, together with our previously published mechanisms of gene expression modulation related to key metabolic pathways in lipid metabolism, provide impetus for much larger clinical studies. Irvingia gabonensis extract may prove to be a useful tool in dealing with the

  18. Creating Virtual Exhibitions for Educational and Cultural Development

    Directory of Open Access Journals (Sweden)

    Gabriela DUMITRESCU

    2014-01-01

    Full Text Available The paper presents different tools and mechanisms to implement a virtual exhibition in different cultural areas, such as museums and libraries. Quality characteristics of virtual exhibitions are identified and described. The possibility to create native mobile applications for virtual exhibitions presentation is analyzed. The functional flow of creating a virtual exhibition is presented and discussed. The Seals - History Treasure exhibition is presented and significant historical documents are revealed.

  19. Communicating Complex Sciences by Means of Exhibitions

    Science.gov (United States)

    Schneider, S.

    2011-12-01

    Earth Sciences will have to take over the leading role in global sustainable policy and in discussions about climate change. Efforts to raise attention within the politically responsible communities as well as in the public are getting more and more support by executive and advisory boards all over the world. But how can you successfully communicate complex sciences? For example, to start communication about climate change, the first step is to encourage people to be concerned about climate change. After that, one has to start thinking about how to present data and how to include the presented data into an unprejudiced context. Therefore, the communication toolbox offers various methods to reach diverse audiences. The R&D programme GEOTECHNOLOGIEN conducts roving exhibitions as one of its most successful communication tools. With roving exhibitions GEOTECHNOLOGIEN is able to get in touch with different audiences at once. The main purpose and theme of these exhibitions is to convey the everyday means of climate change to the visitors. It is within the responsibility of science to communicate the effects of a phenomenon like climate change as well as the impact of research results to the everyday life of people. Currently, a GEOTECHNOLOGIEN roving exhibition on remote sensing with satellites deals with various issues of environmental research, including a chapter on climate change. By following the 3M-concept (Meaning - Memorable - Moving), exhibitions allow to connect the visitors daily environment and personal experiences with the presented issues and objects. Therefore, hands-on exhibits, exciting multimedia effects and high-tech artefacts have to be combined with interpretive text elements to highlight the daily significance of the scientific topics and the exhibition theme respectively. To create such an exhibition, strong conceptual planning has to be conducted. This includes the specification of stern financial as well as time wise milestones. In addition

  20. Protein Extractability

    African Journals Online (AJOL)

    human nutrition, particularly in developing ... studied the effect of NaCl on the extractability of ... significant influence on the functional properties ..... Malaka, S. L. O. and Amund, O. O. Studies on the Life Cycle and Morphometrics of Honeybees,.

  1. Green Revolution for Exhibition Industry

    Institute of Scientific and Technical Information of China (English)

    Yan Manman

    2010-01-01

    @@ Shanghai World Expo is widely regarded as another grand international pageant, so many people thought that the opening ceremony must be as much magnificent and brilliant as the opening ceremony for Beijing Olympics.However, it was revealed by Wan Jifei, Executive Director of the ExecutiveCommittee of the Shanghai World Expo that the opening ceremony of the Expo was not that luxurious and extravagant as that for the Beijing Olympics, but would have its own characteristics under the elaborate design and thorough arrangement conducted by the host. The veto against that luxurious opening ceremony was actually a practice echoing for the concept of Green World Expo, which would be applied for every corner from the beginning to the end of the Expo, including the construction of exhibition hall, building of exhibition stand and advertisement etc.

  2. A New Exhibition in Microcosm

    CERN Multimedia

    2000-01-01

    Sebastien Pelletier explains states of matter to an enthusiastic group of youngsters during the opening of a new exhibition in Microcosm last week. The Fun with Physics workshop will be offered to all 13-14 year olds in school groups visiting CERN this year. The new Microcosm contents have been developed in collaboration with the local teaching community, and cover particles and the forces that act between them.

  3. "Big Science" exhibition at Balexert

    CERN Multimedia

    2008-01-01

    CERN is going out to meet those members of the general public who were unable to attend the recent Open Day. The Laboratory will be taking its "Big Science" exhibition from the Globe of Science and Innovation to the Balexert shopping centre from 19 to 31 May 2008. The exhibition, which shows the LHC and its experiments through the eyes of a photographer, features around thirty spectacular photographs measuring 4.5 metres high and 2.5 metres wide. Welcomed and guided around the exhibition by CERN volunteers, shoppers at Balexert will also have the opportunity to discover LHC components on display and watch films. "Fun with Physics" workshops will be held at certain times of the day. Main hall of the Balexert shopping centre, ground floor, from 9.00 a.m. to 7.00 p.m. Monday to Friday and from 10 a.m. to 6 p.m. on the two Saturdays. Call for volunteers All members of the CERN personnel are invited to enrol as volunteers to help welcom...

  4. Mobile Technologies in Museum Exhibitions

    Directory of Open Access Journals (Sweden)

    Sandra Medić

    2014-10-01

    Full Text Available In order to be up–to–date and give visitors a memorable and unique experience, museums are including usage of digital technologies in their exhibitions. Even though museums in Serbia are very important part of tourism offer, they still have traditional settings that are poorly interpreted. The majority of them have a scientific and historical review which is unattractive for various target groups of visitors and for museums it’s important to continually try out new ways in interpretation of their settings. Because technology continues to rapidly change the way we communicate, cultural institutions should adapt to new ways of communication with their visitors. This paper examines mobile technologies that can be used in museums to give visitors a different experience and transfer the knowledge innovatively. In that way it will be presented the modern concept of presentation of museum exhibitions, focusing on usage of mobile devices through mobile applications and QR codes. The paper provides the broad understanding of usage mobile technologies in museum exhibitions with its advantages and limitations. The research results can help the museums management to improve interpretation and communication with visitors and enrich the visitor experience.

  5. Curated exhibitions and Australian art history

    Directory of Open Access Journals (Sweden)

    Catherine De Lorenzo

    2011-06-01

    Full Text Available Australian Art history in all it guises has tended to bypass the impact of contemporary curated exhibitions on shaping the discipline. Yet an examination of a cluster of key contemporary exhibitions from the early 1970s onwards reveals their significance for the history of art in Australia. They reflect institutional judgements behind the selection, research and display the work of artists as well as the reception of such work by the public, artists, art critics and art historians. This is especially so in the last decades of the 20th century and the first decade of the 21st, as the country underwent major cultural changes. This paper focuses on selected exhibitions of Australian art from 1968 to 2008 and indicates how exhibitions also constitute a major form of contemporary Australian art historiography. As this period coincides with a transformation in the way exhibitions were funded, it also begins to investigate the question of the long term impact of public funding of the arts.

  6. Allelopathic Potential of Cucumber Tissues Aqueous Extracts

    Institute of Scientific and Technical Information of China (English)

    DONG Lin-lin; HAO Zhi-peng; ZUO Yuan-mei; LI Xiao-lin; WANG Qian

    2011-01-01

    [ Objective] The aim of this study was to explore allelopathic effects of the water-extracted crude of cucumber plant parts on seed germination and seedling growth of lettuce ( Lactuca sativa L. ), cabbage ( Brassica pekinensis L. ), radish ( Raphanus sativus L. ) and scallion ( Allium fistulosum L. ). [ Method] The allelopathic effects of different cucumber tissues aqueous extracts were investigated on lettuce, cabbage,radish and scallion using the water-soluble allelopathic principle by seedling bioassay tests. [ Result] The trends of inhibitory effects of different cucumber parts increased with increasing extract concentrations. The inhibition effects and the inhibition rate of three aqueous extracts were more significant on root growth than shoot length. Leaf aqueous extracts represented the most exhibited and root aqueous extracts representing the least inhibitory on seed germination, shoot length and root length of lettuce, cabbage, radish and scallion. [Conclusion] This study had provided basis for allelopathic character of different cucumber plant parts.

  7. The Exhibition Performance Appraisal Index System Based on Stakeholder Theory

    Institute of Scientific and Technical Information of China (English)

    YAN Shu-min; HAO Qi-hui

    2009-01-01

    Exhibition performance should be evaluated from different perspectives of stakeholders. The benefits of each stakeholder can not be satisfied when evaluating the exhibition performance from a single perspective or. only evaluating the economic performance of the exhibition. In this paper, the stakeholders are defined on the basis of questionnaire investigation and classified by mathematical statistical method. According to the requirements of the stakeholders, the exhibition performance appraisal indicators are extracted and, simplified by factor analysis, which leads to the formation of a set of performance appraisal index system. It is an instructive attempt to work out the exhibition performance appraisal model from the perspective of stakeholders, which may provide theoretical foundation and practice instruction for exhibition performance appraisal in our country.

  8. Borneo 2007. Three European Exhibitions

    Directory of Open Access Journals (Sweden)

    Bernard Sellato

    2013-01-01

    Full Text Available The year 2007 appears to have been an exceptionally good one for Borneo in Europe. Two exhibitions were held in France, and one in Switzerland, which prominently featured the big island, its forests, its peoples, its cultures, and its arts. Here a brief review of these three events. Bornéo... Dayak et Punan. Peuples de la forêt tropicale humide, Musée d’Art et d’Archéologie, Laon, France, 25 November 2006 – 11 March 2007 The beautiful city of Laon, only a short distance by train or by car fro...

  9. CERN Permanent exhibitions short version

    CERN Multimedia

    2016-01-01

    Visits Explore by yourself the issues CERN's physicists are trying to solve: given that the entire universe is made of particles, where do they come from? Why do they behave in the way they do? Discover the massive apparatus used by physicists at CERN, like the LHC, and see how each part works. CERN invites the public to discover the mysteries of the Universe and the work of the world's biggest physics laboratory through free of charge guided tours and permanent exhibitions. As a group, with friends, individually, on foot, on your bike, come and discover CERN or explore it virtually. Welcome!

  10. Evaluation of in vitro antioxidant and anti-inflmmatory activities of Ximenia americana extracts

    Directory of Open Access Journals (Sweden)

    Arun Kashivishwanath Shettar

    2015-11-01

    Full Text Available Objective: To evaluate in vitro antioxidant and anti-inflammatory activity of Ximenia americana extracts. Methods: Herbal extraction was done by Soxhlet extraction method with increasing polarity of solvents viz., chloroform, ethyl acetate, methanol, ethanol and water. Phytochemical analysis was done using different biochemical tests. Antioxidant potential of plant extracts were analyzed by ferric ion reducing antioxidant power, phosphomolybdenum and 2,2-diphenyl-1- picrylhydrazyl, and anti-inflammatory activity by using protein denaturation in vitro bioassay. Total phenolic content of each extract was also determined to assess their corresponding effect on antioxidant capacity of plant. Results: Phytochemical analysis showed that each solvent extract contained broad spectrum of secondary metabolites, phenolic compounds, flavonoids, tannins and glycosides, whereas compared to other solvent extracts, chloroform extract showed negative result for phenolic compounds whereas aqueous extract exhibited the highest phenolic content and the significant antioxidant capacity based on the test performed. Out of all extracts, methanol extract showed high anti-inflammatory activity. Conclusions: The present study revealed that different solvent extracts of Ximenia americana leaves contain broad spectrum of bioactive compounds. Results confirm that aqueous extract exhibited high antioxidant activity and methanol extract exhibited high antiinflammatory activity. Further study requires purification, characterization and structural elucidation of phenolic compounds in both extracts that may help in the development of new phytopharmaceuticals.

  11. Annual Report On China's Exhibition Industry 2009 (III)

    Institute of Scientific and Technical Information of China (English)

    China Council for the Promotion of International T

    2010-01-01

    @@ To better understand China's exhibition industry's development trend, and its policy regulation features, and industrial market characteristics, China Council for the Promotion of International Trade (CCPIT) organizes experts and scholars of the exhibition industry to compile and publish Annual Report on China's Exhibition Industry in both Chinese and English every year since 2004. After years of efforts, the Report has become a significant window for domestic and overseas insiders to know about Chinas exhibition industry.

  12. Enrico Fermi exhibition at CERN

    CERN Document Server

    2002-01-01

    A touring exhibition celebrating the centenary of Enrico Fermi's birth in 1901 will be on display at CERN (Main Building, Mezzanine) from 12-27 September. You are cordially invited to the opening celebration on Thursday 12 September at 16:00 (Main Building, Council Chamber), which will include speechs from: Luciano Maiani Welcome and Introduction Arnaldo Stefanini Celebrating Fermi's Centenary in Documents and Pictures Antonino Zichichi The New 'Centro Enrico Fermi' at Via Panisperna Ugo Amaldi Fermi at Via Panisperna and the birth of Nuclear Medicine Jack Steinberger Fermi in Chicago Valentin Telegdi A Close-up of Fermi and the screening of a documentary video about Fermi: Scienziati a Pisa: Enrico Fermi (Scientists at Pisa: Enrico Fermi) created by Francesco Andreotti for La Limonaia from early film, photographs and sound recordings (In Italian, with English subtitles - c. 30 mins). This will be followed by an aperitif on the Mezz...

  13. Crows spontaneously exhibit analogical reasoning.

    Science.gov (United States)

    Smirnova, Anna; Zorina, Zoya; Obozova, Tanya; Wasserman, Edward

    2015-01-19

    Analogical reasoning is vital to advanced cognition and behavioral adaptation. Many theorists deem analogical thinking to be uniquely human and to be foundational to categorization, creative problem solving, and scientific discovery. Comparative psychologists have long been interested in the species generality of analogical reasoning, but they initially found it difficult to obtain empirical support for such thinking in nonhuman animals (for pioneering efforts, see [2, 3]). Researchers have since mustered considerable evidence and argument that relational matching-to-sample (RMTS) effectively captures the essence of analogy, in which the relevant logical arguments are presented visually. In RMTS, choice of test pair BB would be correct if the sample pair were AA, whereas choice of test pair EF would be correct if the sample pair were CD. Critically, no items in the correct test pair physically match items in the sample pair, thus demanding that only relational sameness or differentness is available to support accurate choice responding. Initial evidence suggested that only humans and apes can successfully learn RMTS with pairs of sample and test items; however, monkeys have subsequently done so. Here, we report that crows too exhibit relational matching behavior. Even more importantly, crows spontaneously display relational responding without ever having been trained on RMTS; they had only been trained on identity matching-to-sample (IMTS). Such robust and uninstructed relational matching behavior represents the most convincing evidence yet of analogical reasoning in a nonprimate species, as apes alone have spontaneously exhibited RMTS behavior after only IMTS training. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Phytochemical, Anti-oxidant and Anthelmintic activities of various leaf extracts of Flacourtia sepiaria Roxb

    Directory of Open Access Journals (Sweden)

    M Sreejith

    2013-12-01

    Conclusions: The results of the present study indicate that the leaf extracts of Flacourtia sepiaria exhibited strong antioxidant activity and possess significant anthelmintic activity and thus it is a good source of antioxidant and anthelmintic constituents.

  15. Genotoxic and cytotoxic action potential of Terminalia citrina, a medicinal plant of ethnopharmacological significance

    Science.gov (United States)

    Akhtar, Muhammad Furqan; Saleem, Ammara; Sharif, Ali; Akhtar, Bushra; Nasim, Maaz Bin; Peerzada, Sohaib; Raza, Moosa; Ijaz, Hira; Ahmed, Shoaib; Shabbir, Maryam; Ali, Sajid; Akbar, Zeeshan; Ul Hassan, Syed Saeed

    2016-01-01

    Most herbal medicines utilized in complementary and alternative medicine lack safety evaluation setting our lives under unwarranted risks. Present study comprised of genotoxic and cytotoxic appraisal of Terminalia citrina fruits which are used as a folklore medicine for treatment of various ailments. Aqueous and ethanolic extracts of T. citrina fruit extracts were evaluated for the presence of different phytochemicals. Genotoxic potential of both the extract of T. citrina was assessed through Ames reverse mutagenicity assay in Salmonella TA 100 and 102 strains. Cytotoxic potential of T. citrina was determined in baby hamster kidney cell line (BHK-21). Statistical analysis was carried out by ANOVA following post hoc test. Phytochemical analysis showed the presence of alkaloids, carbohydrates, phenolic compounds, tannins, catechins and saponins. It was revealed that both the extracts of T. citrina exhibited significant mutagenicity in tester strains. Ethanolic extract showed higher mutagenicity in TA 100 strain, whereas aqueous extract of T. citrina exhibited higher mutagenicity in TA 102 strain than TA 100. Both the extracts of T. citrina showed dose-dependent mutagenicity. Fifty percent cell viability was exhibited by 260 and 545 µg/mL of ethanolic and aqueous extracts respectively. This study concludes that the ethanolic and aqueous fruit extracts of T. citrina may not be safe owing to their mutagenic and cytotoxic potential and it necessitates further investigation regarding its safety evaluation. PMID:28096789

  16. The "Gravity-Powered Calculator," a Galilean Exhibit

    Science.gov (United States)

    Cerreta, Pietro

    2014-01-01

    The Gravity-Powered Calculator is an exhibit of the Exploratorium in San Francisco. It is presented by its American creators as an amazing device that extracts the square roots of numbers, using only the force of gravity. But if you analyze his concept construction one can not help but recall the research of Galileo on falling bodies, the inclined…

  17. The "Gravity-Powered Calculator," a Galilean Exhibit

    Science.gov (United States)

    Cerreta, Pietro

    2014-01-01

    The Gravity-Powered Calculator is an exhibit of the Exploratorium in San Francisco. It is presented by its American creators as an amazing device that extracts the square roots of numbers, using only the force of gravity. But if you analyze his concept construction one can not help but recall the research of Galileo on falling bodies, the inclined…

  18. Cystamine preparations exhibit anticoagulant activity.

    Science.gov (United States)

    Aleman, Maria M; Holle, Lori A; Stember, Katherine G; Devette, Christa I; Monroe, Dougald M; Wolberg, Alisa S

    2015-01-01

    Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl)-lysyl crosslinks between proteins. Cystamine blocks transglutaminase activity and is used in vitro in human samples and in vivo in mice and rats in studies of coagulation, immune dysfunction, and inflammatory disease. These studies have suggested cystamine blocks fibrin crosslinking and has anti-inflammatory effects, implicating transglutaminase activity in the pathogenesis of several diseases. We measured the effects of cystamine on fibrin crosslinking, tissue factor-triggered plasma clot formation and thrombin generation, and coagulation factor enzymatic activity. At concentrations that blocked fibrin crosslinking, cystamine also inhibited plasma clot formation and reduced thrombin generation. Cystamine inhibited the amidolytic activity of coagulation factor XI and thrombin towards chromogenic substrates. These findings demonstrate that cystamine exhibits anticoagulant activity during coagulation. Given the close relationship between coagulation and inflammation, these findings suggest prior studies that used cystamine to implicate transglutaminase activity in disease pathogenesis warrant re-examination.

  19. Cystamine preparations exhibit anticoagulant activity.

    Directory of Open Access Journals (Sweden)

    Maria M Aleman

    Full Text Available Transglutaminases are a superfamily of isoenzymes found in cells and plasma. These enzymes catalyze the formation of ε-N-(γ-glutamyl-lysyl crosslinks between proteins. Cystamine blocks transglutaminase activity and is used in vitro in human samples and in vivo in mice and rats in studies of coagulation, immune dysfunction, and inflammatory disease. These studies have suggested cystamine blocks fibrin crosslinking and has anti-inflammatory effects, implicating transglutaminase activity in the pathogenesis of several diseases. We measured the effects of cystamine on fibrin crosslinking, tissue factor-triggered plasma clot formation and thrombin generation, and coagulation factor enzymatic activity. At concentrations that blocked fibrin crosslinking, cystamine also inhibited plasma clot formation and reduced thrombin generation. Cystamine inhibited the amidolytic activity of coagulation factor XI and thrombin towards chromogenic substrates. These findings demonstrate that cystamine exhibits anticoagulant activity during coagulation. Given the close relationship between coagulation and inflammation, these findings suggest prior studies that used cystamine to implicate transglutaminase activity in disease pathogenesis warrant re-examination.

  20. EU Climate Change Exhibition Held

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>On April 25, the CPAFFC, the China-EU Association (CEUA) and the Delegation of the European Commission to China jointly held the opening ceremony for the EU Exhibition on Climate Change in the CPAFFC. He Luli, former vice chairperson of the NPC Standing Committee and honorary president of the CEUA, Jose Manuel Barroso, president of the European Commission, and Li Jianping, vice president of the CPAFFC, attended the opening ceremony and made speeches. Honorary President He Luli highly praised the achievements made by China and the EU in their longtime cooperation of mutual benefits in various fields including environmental protection. She said, for many years China and EU have both committed to the development of all-round strategic partnership and establishment of a multi-level mechanism of political dialogue. She expressed, with increasing enthusiasm the CEUA would continue to actively carry out nongovernmental exchanges between China and the EU, and promote cooperation between the two sides in the fields of economy, society, environmental protection, science and technology, culture, etc.

  1. Antimicrobial Effect of Extracts of Cruciferous Vegetables

    Directory of Open Access Journals (Sweden)

    Shu-Hui Hu

    2004-12-01

    Full Text Available The cruciferous vegetables cauliflower, broccoli, cabbage, Chinese radish, Chinese kale, and Chinese kitam were used in this study to prepare water-soluble and methanol-water extracts. Crude protein extracts were also obtained by diethylaminoethyl (DEAE anion exchange chromatography. Water-soluble polysaccharides were prepared by ethanol precipitation followed by ultrafiltration. The antimicrobial effects of all these extracts were evaluated against Gram-positive bacteria, Gram-negative bacteria, and yeast. Crude protein extracts exhibited the greatest antimicrobial activity in monoculture experiments. The antimicrobial effects of cruciferous vegetables were also studied by steeping beef, carrot, and celery in chlorine (10 ppm or citric acid solution (1% containing the crude protein extract (500 ppm for different time periods. Total aerobic plate counts and coliform counts on these foods decreased significantly after 10 minutes in all steeping solutions (p < 0.05.

  2. DNA extraction protocol for rapid PCR detection of pathogenic bacteria.

    Science.gov (United States)

    Brewster, Jeffrey D; Paoli, George C

    2013-11-01

    Twelve reagents were evaluated to develop a direct DNA extraction method suitable for PCR detection of foodborne bacterial pathogens. Many reagents exhibited strong PCR inhibition, requiring significant dilution of the extract with a corresponding reduction in sensitivity. Most reagents also exhibited much lower recovery of DNA from the gram-positive test organism (Listeria monocytogenes) than from the gram-negative organism (Escherichia coli O157:H7), preventing unbiased detection and quantitation of both organisms. The 5× HotSHOT+Tween reagent exhibited minimal inhibition and high extraction efficiency for both test organisms, providing a 15-min single-tube DNA-extraction protocol suitable for highly sensitive quantitative PCR assays. Published by Elsevier Inc.

  3. Effects of Inula viscosa leaf extracts on abortion and implantation in rats.

    Science.gov (United States)

    Al-Dissi, N M; Salhab, A S; Al-Hajj, H A

    2001-09-01

    The anti-implantation and mid-term abortifacient effects exhibited by administration of Inula viscosa leaf extracts, were studied in rats. The aqueous extract administered i.p. on day 1-6 of gestation, totally diminished fetal implantation and caused a significant (P<0.05) reduction in the number of corpora lutea and blood progesterone levels. Meanwhile, administration on day 13-15 of gestation exhibited mid-term abortion. Furthermore, petroleum ether and dichloromethane, but not methanol, extracts exhibited pronounced abortifacient effects. The results of this study are in agreement with the traditional reputation of this plant as abortifacient. Further, the plant possesses anti-implantational and luteolytic effects.

  4. A phytosterol enriched refined extract of Brassica campestris L. pollen significantly improves benign prostatic hyperplasia (BPH) in a rat model as compared to the classical TCM pollen preparation Qianlie Kang Pule'an Tablets.

    Science.gov (United States)

    Wang, Ruwei; Kobayashi, Yuta; Lin, Yu; Rauwald, Hans Wilhelm; Fang, Ling; Qiao, Hongxiang; Kuchta, Kenny

    2015-01-15

    In Qinghai Province, the Brassica campestris L. pollen preparation Qianlie Kang Pule'an Tablet (QKPT) is traditionally used for BPH therapy. However, in QKPT the content of supposedly active phytosterols is relatively low at 2.59%, necessitating high doses for successful therapy. Therefore, a phytosterol enriched (4.54%) refined extract of B. campestris pollen (PE) was developed and compared with QKPT in a BPH rat model. Six groups of rats (n=8 each), namely sham-operated distilled water control, castrated distilled water control, castrated QKPT 2.0g/kg, castrated PE 0.1g/kg, castrated PE 0.2g/kg, and castrated PE 0.4g/kg, were intragastrically treated with the respective daily doses. Testosterone propionate (0.3mg/day) was administered to all castrated rats, while the sham-operated group received placebo injections. After 30 days, the animals were sacrificed and prostates as well as seminal vesicles excised and weighted in order to calculate prostate volume index (PVI) as well as prostate index (PI) and seminal vesicle index (SVI), defined as organ weight in g per 100g body weight. Compared with sham-operated controls, PI (p<0.01), PVI (p<0.01), and SVI (p<0.01) were all significantly increased in all castrated, testosterone treated rats. After treatment with PE at 0.4 and 0.2g/kg or QKPT at 2.0g/kg per day, both indices were significantly reduced (p<0.01) as compared to the castrated distilled water control. For PE at 0.1g/kg per day only PI was significantly reduced (p<0.05). At the highest PE concentration of 0.4g/kg per day both PI and SVI were also significantly reduced when compared to the QKPT group (p<0.05). Both PE and QKPT demonstrated curative effects against BPH in the applied animal model. In its highest dose at 0.4g/kg per day, PE was clearly superior to QKPT.

  5. Liu Hong: no trivial on exhibitions

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    To Work for Tomorrow Liu Hong, General Manager of TUTTI Exhibition Service (Xiamen) Co., Ltd, has set up TUTTI Exhibition Service (Xiamen) Co., Ltd in 2001, when exhibition industry firstly appear in Xiamen. Furthermore, the company has developed rapidly in recent years. As Liu Hong regards, exhibition industry, as well as advertisement industry, is an industry filled with challenges and followed

  6. Toxicological investigations of Aloe ferox Mill. extracts using Brine shrimp (Artemia salina L.) assay.

    Science.gov (United States)

    Abosede, Wintola Olubunmi; Sunday, Arowosegbe; Jide, Afolayan Anthony

    2015-03-01

    Cytotoxicity of the extracts of Aloe ferox using brine shrimp was evaluated. Effects of the extracts on hatchability and lethality of brine shrimps were reported in terms of minimum inhibitory concentration and LD(50) respectively. The hatching success was in the order: aqueous root extract (39.8%) >aqueous leaf (26.5%) >acetone leaf (13.7%) > ethanol leaf extracts (2.5%). Hatchability in incubations of ethanol and acetone extracts was found to be dose - dependent, with hatching success decreasing as the concentration of the extracts increased. The lethality of extracts was in the order: aqueous leaf extract (4.7%) >aqueous root extract (4.2%) >acetone leaf extract (3.5%) >ethanol root extract (2.6%) > ethanol leaf extract (1.8%) >acetone root extract (0.7%). Mean mortality of nauplii in the control was higher (6.7%) than that of all the extracts. Based on Meyer's index of toxicity, the acetone leaf extract with LD(50) >1.0mg/mL could be considered as non toxic, while the ethanol root extract (LD(50) brine shrimp. Since the extracts of A. ferox have consistently exhibited significant pharmaceutical properties in-vitro, the non-toxic extracts could further be exploited for the development of plant-based pharmaceuticals.

  7. Antiulcer activity of aqueous and ethanolic extracts of Ocimum sanctum leaves in albino rats

    Directory of Open Access Journals (Sweden)

    Sowmya Kaniganti

    2016-08-01

    Conclusions: Both the doses of aqueous and ethanolic extracts of Ocimum sanctum leaves exhibited significant antiulcer activity in pyloric ligation model, whereas only 200 mg/kg of aqueous leaf extract was effective in cold restrain stress model. [Int J Basic Clin Pharmacol 2016; 5(4.000: 1353-1358

  8. Belongings: Oral History, Objects and an Online Exhibition

    Directory of Open Access Journals (Sweden)

    Janis Wilton

    2009-11-01

    Full Text Available The New South Wales Migration Heritage Centre was established in 1998. Since 2003 its physical presence has been located within Sydney’s Powerhouse Museum and it has had the strategic brief to record the memories of ageing migrants before their stories are lost. The Centre is, however, a museum without a collection; a heritage authority without heritage sites; a cultural institution whose main presence is in cyberspace. Among its high profile projects is one entitled Objects through time and another Belongings. Both focus on the ways in which objects can convey aspects of the migration experience. Belongings, the focus of this article, presents the remembered experiences of people who migrated to Australia after World War II, and seeks to highlight significant features of their experiences through asking them to share their memories and to nominate and talk about significant objects. As a project it grew out of movable heritage policy work within state government agencies, and its initiators – John Petersen, Kylie Winkworth and Meredith Walker – were central players in this development. It was also inspired by the National Quilt Register of the Pioneer Women’s Hut at Tumbarumba. With its object-centred approach and accompanying edited interview transcripts, Belongings provides a focus for exploring the messages and emphases that emerge when oral history interviews concerned with migration have the specific brief to ask about material culture and its significance. Belongings also enables an exploration of the layering of those messages that emerges when object captions are located back in the context of the oral history interviews from which they were extracted. As a virtual exhibition, Belongings also provides the opportunity to consider the challenges for museums (virtual and real when they need to condense the richness of migrant oral histories and life stories to captioned objects that can be put on display.

  9. Analgesic profile of hydroalcoholic extract obtained from Marrubium vulgare.

    Science.gov (United States)

    de Souza, M M; de Jesus, R A; Cechinel-Filho, V; Schlemper, V

    1998-04-01

    Marrubium vulgare L. is a medicinal plant used in folk medicine to cure a variety of diseases. Recently we have demonstrated that a hydroalcoholic extract of this plant showed significant, nonspecific antispasmodic effects on isolated smooth muscle. In this report, we have investigated the possible analgesic effects of the same hydroalcoholic extract in different models of pain in mice. The results suggest that this extract exhibits significant analgesic activity, antagonizing chemically-induced acute pain. Such effects may be related to the presence of steroids and terpenes, which were detected by TLC analysis.

  10. VNU Exhibitions Asia: Two factors are crucial

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Reporter: How to appraises the Chinese exhibition industry market? Jime Essink :The Chinese exhibition market will experience a fast growth in the coming years. This will mainly be the result of an increase of international visitors who

  11. Report on Exhibition Industry in Shanghai

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ 1. General Characteristics of Shanghai Exhibitions As the leader of economic development in the Yangtze River Delta,Shanghai has basically formed a certain scale and strength in the aspects of urban transportation, exhibition venues, supporting facilities, service levels, etc.

  12. Development Report on Exhibition Industry in Guangzhou

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    @@ Ⅰ. Generat Features of Guangzhou Exhibitions (Ⅰ) Quantity of Exhibitions and Industry Features. Overall, after suf-fering from global financial crisis in 2008 as well as the interference of Beijing Olympic Games and other major events, the exhibition industry in Guangzhou has still not encountered an easy condition in 2009.

  13. Beijing Lack of "Carrier"Exhibition Center

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    An Interview towards Mr. Chu Xiangyin, Vice Chairman of Beijing Subcouncil, CCPIT Reporter: Would you please tell us development of exhibition industry in Beijing? Chu Xiangyin: Beijing Statistical Bureau and us have been designing and analyzing statistical system for exhibition industry from 2003. As the largest exhibition center in Beijing,

  14. Affordances and distributed cognition in museum exhibitions

    DEFF Research Database (Denmark)

    Achiam, Marianne; May, Michael; Marandino, Martha

    2014-01-01

    consistent framework. Here, we invoke the notions of affordance and distributed cognition to explain in a coherent way how visitors interact with exhibits and exhibit spaces and make meaning from those interactions, and we exemplify our points using observations of twelve visitors to exhibits at a natural...... history museum. We show how differences in exhibit characteristics give rise to differences in the interpretive strategies used by visitors in their meaning-making process, and conclude by discussing how the notions of affordance and distributed cognition can be used in an exhibit design perspective....

  15. Aphrodisiac activity of methanol extract of leaves of Passiflora incarnata Linn in mice.

    Science.gov (United States)

    Dhawan, Kamaldeep; Kumar, Suresh; Sharma, Anupam

    2003-04-01

    The aphrodisiac properties of the methanol extract of leaves of Passiflora incarnata Linn. have been evaluated in mice by observing the mounting behaviour. The methanol extract of P. incarnata exhibited significant aphrodisiac behaviour in male mice at all doses, i.e. 75, 100 and 150 mg/kg. Amongst these, the highest activity was observed with the 100 mg/kg dose when the mountings were calculated about 95 min after the administration of the test extracts.

  16. 76 FR 30228 - Culturally Significant Object Imported for Exhibition; Determinations: “Portrait of a Man”

    Science.gov (United States)

    2011-05-24

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, and Delegation of Authority No.......

  17. Absence of Significant Cool Disks in Young Stellar Objects Exhibiting Repetitive Optical Outbursts

    CERN Document Server

    Liu, Hauyu Baobab; Vorobyov, Eduard I; Kóspál, Ágnes; Rodríguez, Luis F; Dunham, Michael M; Hirano, Naomi; Henning, Thomas; Takami, Michihiro; Dong, Ruobing; Hashimoto, Jun; Hasegawa, Yasuhiro; Carrasco-González\\, Carlos

    2015-01-01

    We report Submillimeter Array (SMA) 1.3 mm high angular resolution observations towards the four EXor type outbursting young stellar objects (YSOs) VY Tau, V1118 Ori, V1143 Ori, and NY Ori. The data mostly show low dust masses $M_{dust}$ in the associated circumstellar disks. Among the sources, NY Ori possesses a relatively massive disk with $M_{dust} \\sim 9 \\times 10^{-4}$ $M_{\\odot}$. V1118 Ori has a marginal detection equivalent to $M_{dust} \\sim 6 \\times 10^{-5}$ $M_{\\odot}$. V1143 Ori has a non-detection also equivalent to $M_{dust} < 6 \\times 10^{-5}$ $M_{\\odot}$. For the nearest source VY Tau, we get a surprising non-detection which provides a stringent upper limit $M_{dust} < 6 \\times 10^{-6}$ $M_{\\odot}$. We interpret our findings as suggesting that the gas and dust reservoirs that feed the short duration, repetitive optical outbursts seen in some EXors may be limited to the small scale, innermost region of their circumstellar disks. This hot dust may have escaped our detection limits. Follow-u...

  18. 75 FR 9013 - Culturally Significant Objects Imported for Exhibition Determinations: “Vienna Circa 1780: An...

    Science.gov (United States)

    2010-02-26

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No. 236......

  19. ABSENCE OF SIGNIFICANT COOL DISKS IN YOUNG STELLAR OBJECTS EXHIBITING REPETITIVE OPTICAL OUTBURSTS

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Hauyu Baobab; Hirano, Naomi; Takami, Michihiro; Dong, Ruobing [Academia Sinica Institute of Astronomy and Astrophysics, P.O. Box 23-141, Taipei 106, Taiwan (China); Galván-Madrid, Roberto; Rodríguez, Luis F.; Carrasco-González, Carlos [Instituto de Radioastronomía y Astrofísica, UNAM, A.P. 3-72, Xangari, Morelia, 58089 (Mexico); Vorobyov, Eduard I. [Department of Astrophysics, University of Vienna, Tuerkenschanzstrasse 17, A-1180, Vienna (Austria); Kóspál, Ágnes [Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences, P.O. Box 67, 1525 Budapest (Hungary); Dunham, Michael M. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, MS 78, Cambridge, MA 02138 (United States); Henning, Thomas [Max-Planck-Institut für Astronomie Königstuhl, 17 D-69117 Heidelberg (Germany); Hashimoto, Jun [National Astronomical Observatory of Japan, 2-21-1 Osawa, Mitaka, Tokyo 181-8588 Japan (Japan); Hasegawa, Yasuhiro, E-mail: baobabyoo@gmail.com [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States)

    2016-01-10

    We report Submillimeter Array 1.3 mm high angular resolution observations toward the four EXor-type outbursting young stellar objects VY Tau, V1118 Ori, V1143 Ori, and NY Ori. The data mostly show low dust masses M{sub dust} in the associated circumstellar disks. Among the sources, NY Ori possesses a relatively massive disk with M{sub dust} ∼ 9 × 10{sup −4}M{sub ⊙}. V1118 Ori has a marginal detection equivalent to M{sub dust} ∼ 6 × 10{sup −5}M{sub ⊙}. V1143 Ori has a non-detection also equivalent to M{sub dust} < 6 × 10{sup −5}M{sub ⊙}. For the nearest source, VY Tau, we get a surprising non-detection that provides a stringent upper limit M{sub dust} < 6 × 10{sup −6}M{sub ⊙}. We interpret our findings as suggesting that the gas and dust reservoirs that feed the short-duration, repetitive optical outbursts seen in some EXors may be limited to the small-scale, innermost region of their circumstellar disks. This hot dust may have escaped our detection limits. Follow-up, more sensitive millimeter observations are needed to improve our understanding of the triggering mechanisms of EXor-type outbursts.

  20. 78 FR 60994 - Culturally Significant Objects Imported for Exhibition Determinations: “Christopher Wool”

    Science.gov (United States)

    2013-10-02

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  1. A Nanotube Surface Reinforced Graphite Fiber Exhibiting Significantly Enhanced Properties Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The completed Phase I work was directed at the application of nanotechnology to graphite/epoxy composites. A novel approach to the application of the nanotubes onto...

  2. 76 FR 53524 - Culturally Significant Objects Imported for Exhibition Determinations: “Mirror of the Buddha...

    Science.gov (United States)

    2011-08-26

    ...Notice is hereby given of the following determinations: Pursuant to the authority vested in me by the Act of October 19, 1965 (79 Stat. 985; 22 U.S.C. 2459), Executive Order 12047 of March 27, 1978, the Foreign Affairs Reform and Restructuring Act of 1998 (112 Stat. 2681, et seq.; 22 U.S.C. 6501 note, et seq.), Delegation of Authority No. 234 of October 1, 1999, Delegation of Authority No.......

  3. 75 FR 22172 - Culturally Significant Objects Imported for Exhibition Determinations: “Vatican Splendors”

    Science.gov (United States)

    2010-04-27

    ... objects at the Missouri History Museum, Saint Louis, Missouri, from on or about May 15, 2010, until on or about September 12, 2010, the Senator John Heinz History Center, Pittsburgh, Pennsylvania, from on or about October 2, 2010, until on or about January 9, 2011, the Museum of Art, Nova...

  4. 75 FR 1009 - Culturally Significant Objects Imported for Exhibition Determinations: “Habsburg Treasures”

    Science.gov (United States)

    2010-01-07

    ... at the Norton Museum of Art, West Palm Beach, Florida, from on or about January 16, 2010, until on or about April 11, 2010; the Columbia Museum of Art, Columbia, South Carolina, from on or about May 21..., Florida, from on or about October 7, 2010, until on or about December 30, 2010, and at possible...

  5. 75 FR 53731 - Culturally Significant Objects Imported for Exhibition Determinations: “Sheila Hicks: 50 Years”

    Science.gov (United States)

    2010-09-01

    ... on or about November 5, 2010, until on or about February 27, 2011; at the Institute of Contemporary Art, University of Pennsylvania, Philadelphia, PA, from on or about March 25, 2011, until on or...

  6. Extraction parameters for metabolomics from cell extracts

    Science.gov (United States)

    Ser, Zheng; Liu, Xiaojing; Tang, Ngoc Nu; Locasale, Jason W

    2015-01-01

    The successful extraction of metabolites is a critical step in metabolite profiling. By optimizing metabolite extraction, the range and quantitative capacity of metabolomics studies can be improved. We considered eight separate extraction protocols for the preparation of a metabolite extract from cultured mammalian cells. Parameters considered included temperature, pH, and cell washing before extraction. The effects on metabolite recovery were studied using a high resolution liquid chromatography mass spectrometry (LC-HRMS) platform that measures metabolites of diverse chemical classes including among others amino acids, lipids, and sugar derivatives. The temperature considered during the extraction or the presence of formic acid, a commonly used additive, was shown to have minimal effects on the measured ion intensities of metabolites. However, washing of samples before metabolite extraction whether with water or PBS (both commonly considered practices) exhibited dramatic effects on measured intensities of both intra- and extra-cellular metabolites. Together these findings present a systematic assessment of extraction conditions for metabolite profiling. PMID:25613493

  7. extract attenuates MPTP-induced oxidative stress and behavioral ...

    African Journals Online (AJOL)

    on oxidative stress levels were assessed by estimating enzyme status, ... Results: MPTP (25 mg/kg, i.p.)-treated mice resulted in a significant (p ... Conclusion: CCY extract exhibits strong protection against MPTP-induced behavioral deficit through ..... cuminol, cymine, cuminaldehyde, limonene, ... Antibacterial effect of plant.

  8. Investigating Design Research Landscapes through Exhibition

    DEFF Research Database (Denmark)

    Jönsson, Li; Hansen, Flemming Tvede; Mäkelä, Maarit;

    2013-01-01

    What characterizes a design research exhibition compared to a traditional design and art exhibition? How do you show the very materialities of the design experiments as a means for communicating knowledge of research and of practice? How do you present, review and utilize such an exhibition......? With those questions in mind, the intention and challenge for the Nordes 2013 Design Research Exhibition was to expand on current notions of staging research enquires in design research conference contexts. Artefacts, installations, performances, and other materialities that relate to the theme...... of the conference - Experiments in Design Research – were displayed as tools to express and communicate different design research enquires. Through this paper we will describe the Nordes exhibition as a specific case that renders questions visible in relation to how to utilize a design research exhibition...

  9. Lipid-lowering and antioxidant functions of bottle gourd (Lagenaria siceraria) extract in human dyslipidemia.

    Science.gov (United States)

    Katare, Charu; Saxena, Sonali; Agrawal, Supriya; Joseph, Anish Zacharia; Subramani, Senthil Kumar; Yadav, Dhananjay; Singh, Nita; Bisen, Prakash Singh; Prasad, G B K S

    2014-04-01

    The study validated the antidyslipidemic, antioxidant, and antihyperglycemic effects of Lagenaria siceraria fruit extract in human subjects with dyslipidemia along with subjects of normal health. A total of 200 mL of freshly prepared Lagenaria siceraria fruit extract was administered daily on empty stomach for 90 days. Significant reductions (P Lagenaria siceraria fruit extract exhibited significant antioxidant activity in dyslipidemic subjects as evident from elevations in SOD (P Lagenaria siceraria fruit extract serves as dietary adjunct in treatment of human dyslipidemia and cardiovascular disease.

  10. Antioxidant Activity of the Successive Extracts of Aesculus indica Leaves

    Directory of Open Access Journals (Sweden)

    Guno Sindhu Chakraborthy

    2009-07-01

    Full Text Available Plants are the best source of active secondary metabolites which are beneficial to mankind. Many plant origin drugs have been reported with biological properties like Analgesic, Anti-inflammatory, Antioxidant, hypoglycemic agents and many more. The successive extracts of Aesculus indica leaves were screened for in vitro antioxidant properties using the standard procedures. The successive extracts such as petroleum ether, ethyl acetate, methanol and water and 50% crude methanol extracts exhibited IC 50 values of respectively in DPPH and respectively in nitric oxide radical inhibition assays. The values are comparable with the standards such as ascorbic acid and quercetin. The Aesculus indica leaves are showing significant antioxidant activity.

  11. Anxiolytic activity of a supercritical carbon dioxide extract of Souroubea sympetala (Marcgraviaceae).

    Science.gov (United States)

    Mullally, Martha; Kramp, Kari; Cayer, Chris; Saleem, Ammar; Ahmed, Fida; McRae, Calum; Baker, John; Goulah, Andrew; Otorola, Marco; Sanchez, Pablo; Garcia, Mario; Poveda, Luis; Merali, Zul; Durst, Tony; Trudeau, Vance L; Arnason, John Thor

    2011-02-01

    The purpose of this work was to develop an extraction technique to yield a betulinic acid-(BA) enriched extract of the traditional anti-anxiety plant Souroubea sympetala Gilg (Marcgraviaceae). Five extraction techniques were compared: supercritical carbon dioxide extraction (SCE), conventional solvent extraction with ethyl acetate (EtOAc), accelerated solvent extraction (ASE), ultrasonic assisted extraction (UAE) and soxhlet extraction (Sox). The EtOAc and SCE extraction methods resulted in BA-enriched extracts, with BA concentrations of 6.78 ± 0.2 and 5.54 ± 0.2 mg/g extract, respectively, as determined by HPLC-APCI-MS. The bioactivity of the BA-enriched extracts was compared in the elevated plus maze (EPM), a validated rodent anxiety behaviour assay. Rats orally administered a 75 mg/kg dose of SCE extract exhibited anxiolysis as compared with vehicle controls, with a 50% increase in the percent time spent in the open arms, a 73% increase in unprotected head dips and a 42% decrease in percent time spent in the closed arms. No significant differences were observed between the SCE and EtOAc extracts for these measures, but the animals dosed with SCE extract had significantly more unprotected head dips than those dosed with the EtOAc extract. The SCE extract demonstrated a dose-response in the EPM, with a trend toward decreased anxiety at 25 mg/kg, and significant anxiolysis was only observed at 75 mg/kg dose. This study demonstrates that SCE can be used to generate a betulinic acid-enriched extract with significant anxiolysis in vivo. Further, the study provides a scientific basis for the ethnobotanical use of this traditional medicine and a promising lead for a natural health product to treat anxiety.

  12. Virtual Exhibition and Fruition of Archaeological Finds

    Science.gov (United States)

    Manferdini, A. M.; Garagnani, S.

    2011-09-01

    During the last two decades, since digital technologies have become more sophisticated in acquiring real data and building faithful copies of them, their improvements have suggested interesting applications in the field of valorisation of Historical, Cultural and Artistic Heritage, with significant consequences in the share and widespread of knowledge. But although several technologies and methodologies for 3d digitization have recently been developed and improved, the lack of a standard procedure and the costs connected to their use still doesn't encourage the systematic digital acquisition of wide collections and heritage. The aim of this paper is to show the state of the art of a project whose aim is to provide a methodology and a procedure to create digital reproductions of artefacts for Institutions called to preserve, manage and enhance the fruition of archaeological finds inside museums or through digital exhibitions. Our project's aim is to find the most suitable procedure to digitally acquire archaeo logical artefacts that usually have small dimensions and have very complex and detailed surfaces. Within our methodology, particular attention has been paid to the use of widely shared and open-source visualization systems that enhance the involvement of the user by emphasizing three-dimensional characteristics of artefacts through virtual reality.

  13. Artefacts and the performance of an exhibition

    DEFF Research Database (Denmark)

    Svabo, Connie

    2008-01-01

    The article explores the role of mediating artefacts in children's encounters with a museum of natural history. Using actor network theory it explores how a specific artefact shapes the way users relate to exhibited objects and how the artefact guides users' movements in the exhibition. The media...

  14. Encountering Nanotechnology in an Interactive Exhibition

    Science.gov (United States)

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  15. Exhibition Economy Set to Boost City Development

    Institute of Scientific and Technical Information of China (English)

    Li Zhen

    2010-01-01

    @@ Awell-developed exhibition industry is usually regarded as an important cri terion in measuring a city's economic and social development level. In recent years, much attention has been paid to exhibition economy for its positive effect on dining, transportation, tourism, advertising, and shopping.

  16. Science Fiction Exhibits as STEM Gateways

    Science.gov (United States)

    Robie, Samantha

    Women continue to hold less than a quarter of all STEM jobs in the United States, prompting many museums to develop programs and exhibits with the express goal of interesting young girls in scientific fields. At the same time, a number of recent museum exhibits have harnessed the popularity of pop culture and science fiction in order to interest general audiences in STEM subject matter, as well as using the exhibits as springboards to expand or shift mission goals and focus. Because science fiction appears to be successful at raising interest in STEM fields, it may be an effective way to garner the interest of young girls in STEM in particular. This research seeks to describe the ways in which museums are currently using science fiction exhibits to interest young girls in STEM fields and careers. Research focused on four institutions across the country hosting three separate exhibits, and included staff interviews and content analysis of exhibit descriptions, promotional materials, a summative evaluation and supplementary exhibit productions. In some ways, science fiction exhibits do serve young girls, primarily through the inclusion of female role models, staff awareness, and prototype testing to ensure interactives are attractive to girls as well as to boys. However, STEM appears to be underutilized, which may be partly due to a concern within the field that the outcome of targeting a specific gender could be construed as "stereotyping".

  17. Encountering Nanotechnology in an Interactive Exhibition

    Science.gov (United States)

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  18. Designing museum exhibits that facilitate visitor reflection and discussion

    DEFF Research Database (Denmark)

    Skydsgaard, Morten Arnika; Andersen, Hanne Møller; King, Heather

    2016-01-01

    personal reflection but also prompted discussion. Participation, defined as including both physical interaction with exhibits, and dialogic interaction between visitors, facilitated the sharing of ideas and feelings between visitors. Exhibits with elements of curiosity and challenge were found to attract...... pupils’ attention but also worked well with other design principles to engage the pupils in sustained reflection and discussion. While other contextual factors remain significant in determining visitor responses, this paper argues that the use of design principles can help create visitor experiences...

  19. Exhibition-based Immersive Performance Environments

    DEFF Research Database (Denmark)

    Svabo, Connie

    2017-01-01

    Art”. This exhibition concept has been awarded the prize “Bikubens Udstillings Visionspris” 2016 for its innovative take on exhibitions. In the Sister’s Academy Boarding School visitors ‘move into’ and inhabit an exhibition for a longer period of time, for example 24 or 48 hours. This radically breaks...... with the conventional 1½ hour duration of museum visits and creates new possibilities of and challenges for presence in museums. The paper analyzes exhibition experience as an engagement, which with its immersive and emergent qualities, radically breaks with visual modes of appreciation. The visitor does not ‘stand...... to the everyday and to conventional modes of being, interaction and communication. The exhibition thus becomes a space of potential; a critical and utopian space for trying out new forms of being and new modes of engagement. Theoretically the paper focuses on Berleant’s environmental aesthetics and the notion...

  20. The Culture of Exhibitions and Conservation

    Directory of Open Access Journals (Sweden)

    Dimitrios Doumas

    2013-11-01

    Full Text Available The article reflects on temporary exhibitions from a theoretical as well as practical perspective. Regarded as a particularly effective mass-communication medium, exhibitions have a dual nature: they are scholarly undertakings, bringing off a curator’s vision and, simultaneously, they are projects with economic implications that need to be well managed and administered. The role of conservation in the making of temporary exhibitions, either in-house or touring, is here discussed in relation to how work is planned and prioritized as well as how time is managed and staff is allocated. Reference to weaknesses that lessen the crucial input of conservation in the decision-making process is also made. Much of the debate, which focuses on art exhibitions, concerns practicalities encountered in a private museum that extend from the very early stages of selecting objects for display to the mounting of an exhibition.

  1. High Quality Virtual Reality for Architectural Exhibitions

    DEFF Research Database (Denmark)

    Kreutzberg, Anette

    2016-01-01

    This paper will summarise the findings from creating and implementing a visually high quality Virtual Reality (VR) experiment as part of an international architecture exhibition. It was the aim to represent the architectural spatial qualities as well as the atmosphere created from combining natural...... and artificial lighting in a prominent not yet built project. The outcome is twofold: Findings concerning the integration of VR in an exhibition space and findings concerning the experience of the virtual space itself. In the exhibition, an important aspect was the unmanned exhibition space, requiring the VR...... and quantitative methods at two different occasions and setups after the exhibition, both showing a high degree of immersion and experience of reality....

  2. Holland at CERN – Industrial exhibition

    CERN Multimedia

    GS Department

    2010-01-01

    Sponsored by EVD, an agency of the Dutch Ministry of the Economy From 8 to 11 November 2010 Industrial Exhibition Administration Building Bldg. 61 9-00 - 17-30 Twenty seven companies will present their latest technology at the industrial exhibition "Holland at CERN". Dutch industry will exhibit products and technologies which are related to the field of particle physics. Individual interviews will take place directly at the stands in the Main Building. The firms will contact relevant users/technicians but any user wishing to make contact with a particular firm is welcome to use the contact details which are available from each departmental secretariat or at the following URL: http://gs-dep.web.cern.ch/gs-dep/groups/sem/ls/Industrial_Exhibitions.htm#Industrial_exhibitions You will find the list of exhibitors below. LIST OF EXHIBITORS: Schelde Exotech Vernooy BV Triumph Group INCAA Computers DeMaCo Holland bv TNO Science & Industry Janssen Precision Engi...

  3. Exhibition of Stochastic Resonance in Vestibular Perception

    Science.gov (United States)

    Galvan-Garza, R. C.; Clark, T. K.; Merfeld, D. M.; Bloomberg, J. J.; Oman, C. M.; Mulavara, A. P.

    2016-01-01

    (OTO) with SVS up to 700 µA. A sinusoidal galvanic vestibular stimulation (GVS) perceptual threshold was also measured on each test day and used to normalize the SVS levels across subjects. In roll-tilt thresholds with SVS, the characteristic SR curve was qualitatively exhibited in 10 of 12 subjects, and the improvement in motion threshold was significant in 6 subjects, indicating that optimal SVS improved passive body motion perception in a way that is consistent with classical SR theory. A probabilistic comparison to numeric simulations further validated these experimental results. On the second test session, 4 out of the 10 SR exhibitors showed repeated improvement with SVS compared to the no SVS condition. Data collection is ongoing for the last two test sessions in which SCC and OTO only perceptual motion recognition thresholds are being measured with SVS. The final results of these test sessions will give insight into whether vestibular perceptual SR can occur when only one type of vestibular sensor is sensing motion or if it is more evident when sensory integration between the SCC and OTO is occurring during the motion. The overall purpose of this research is to further quantify the effects of SVS on various sensorimotor tasks and to gain a more fundamental understanding of how SVS causes SR in the vestibular system. In the context of human space flight, results from this research will help in understanding how SVS may be practically implemented in the future as a component of a comprehensive countermeasure plan for G-transition adaptation.

  4. A mini-exhibition with maximum content

    CERN Multimedia

    Laëtitia Pedroso

    2011-01-01

    The University of Budapest has been hosting a CERN mini-exhibition since 8 May. While smaller than the main travelling exhibition it has a number of major advantages: its compact design alleviates transport difficulties and makes it easier to find suitable venues in the Member States. Its content can be updated almost instantaneously and it will become even more interactive and high-tech as time goes by.   The exhibition on display in Budapest. The purpose of CERN's new mini-exhibition is to be more interactive and easier to install. Due to its size, the main travelling exhibition cannot be moved around quickly, which is why it stays in the same country for 4 to 6 months. But this means a long waiting list for the other Member States. To solve this problem, the Education Group has designed a new exhibition, which is smaller and thus easier to install. Smaller maybe, but no less rich in content, as the new exhibition conveys exactly the same messages as its larger counterpart. However, in the slimm...

  5. Antiobesity effect of Bauhinia variegata bark extract on female rats fed on hypercaloric diet

    Directory of Open Access Journals (Sweden)

    Gunasekaran Balamurugan

    2010-03-01

    Full Text Available The present study was carried out to investigate the antiobesity effect of methanolic extract of stem and root barks of Bauhinia variegata Linn in female rats fed with hypercaloric diet. Obesity was induced by administration of hypercaloric diet for 40 days. The plant extract (at the tested doses of 200 and 400 mg/kg exhibited a significant hypolipidemic effect and thus reduced the obesity. The body weight and feed intake was reduced significantly. Treatment of obese animals with the methanolic extract of B. variegata exhibited an increased brain serotonin level and high density lipoprotein with a concomitant decrease in total cholesterol, triglycerides and low density lipo protein. Thus the study indicates that the antiobesity activity of methanolic extract of B. variegata could be attributed to the presence of β-sitosterol in the stems and the tendency of the extract to reduce lipid profile and elicit the brain serotonin level.

  6. Significant Tsunami Events

    Science.gov (United States)

    Dunbar, P. K.; Furtney, M.; McLean, S. J.; Sweeney, A. D.

    2014-12-01

    Tsunamis have inflicted death and destruction on the coastlines of the world throughout history. The occurrence of tsunamis and the resulting effects have been collected and studied as far back as the second millennium B.C. The knowledge gained from cataloging and examining these events has led to significant changes in our understanding of tsunamis, tsunami sources, and methods to mitigate the effects of tsunamis. The most significant, not surprisingly, are often the most devastating, such as the 2011 Tohoku, Japan earthquake and tsunami. The goal of this poster is to give a brief overview of the occurrence of tsunamis and then focus specifically on several significant tsunamis. There are various criteria to determine the most significant tsunamis: the number of deaths, amount of damage, maximum runup height, had a major impact on tsunami science or policy, etc. As a result, descriptions will include some of the most costly (2011 Tohoku, Japan), the most deadly (2004 Sumatra, 1883 Krakatau), and the highest runup ever observed (1958 Lituya Bay, Alaska). The discovery of the Cascadia subduction zone as the source of the 1700 Japanese "Orphan" tsunami and a future tsunami threat to the U.S. northwest coast, contributed to the decision to form the U.S. National Tsunami Hazard Mitigation Program. The great Lisbon earthquake of 1755 marked the beginning of the modern era of seismology. Knowledge gained from the 1964 Alaska earthquake and tsunami helped confirm the theory of plate tectonics. The 1946 Alaska, 1952 Kuril Islands, 1960 Chile, 1964 Alaska, and the 2004 Banda Aceh, tsunamis all resulted in warning centers or systems being established.The data descriptions on this poster were extracted from NOAA's National Geophysical Data Center (NGDC) global historical tsunami database. Additional information about these tsunamis, as well as water level data can be found by accessing the NGDC website www.ngdc.noaa.gov/hazard/

  7. ANALGESIC ACTIVITY OF LEPIDAGATHIS CRISTATA WILLD FLOWER EXTRACTS

    Directory of Open Access Journals (Sweden)

    Purma Aravinda Reddy

    2013-08-01

    Full Text Available Aim of the study was to screen the Lepidagathis cristata Willd, flower extracts for analgesic activity. In the present study the analgesic activity of flower extracts was performed. The methanolic, ethyl acetate, chloroform extracts were prepared and were used for analgesic activity in two dose level of 200 and 400mg/kg body weight in two screening methods, Hot Plate (n=5 and Tail Immersion method (n=5. The flower extracts showed significant analgesic activity. The plant extracts did not exhibit any mortality up to the dose level 4000mg/kg. The methanol, chloroform and ethyl acetate extracts of flower was evaluated for analgesic activity. The flower ethyl acetate extract of Lepidagathis cristata showed 47% and 57.1% activity at 200 and 400mg/kg.b.wt, after 30 min by Eddy’s Hot plate Method respectively. The flower chloroform extract showed 43.7% and 44.7% protection at 200, 400mg/kg respectively. The flower methanol, chloroform and ethyl acetate extracts showed dose dependent analgesic activity in thermal models. The flower ethylacetate extract has maximum analgesic activity with 57.1% (p < 0.001c.

  8. High Quality Virtual Reality for Architectural Exhibitions

    DEFF Research Database (Denmark)

    Kreutzberg, Anette

    2016-01-01

    This paper will summarise the findings from creating and implementing a visually high quality Virtual Reality (VR) experiment as part of an international architecture exhibition. It was the aim to represent the architectural spatial qualities as well as the atmosphere created from combining natural...... and artificial lighting in a prominent not yet built project. The outcome is twofold: Findings concerning the integration of VR in an exhibition space and findings concerning the experience of the virtual space itself. In the exhibition, an important aspect was the unmanned exhibition space, requiring the VR...... experience to be self-explanatory. Observations of different visitor reactions to the unmanned VR experience compared with visitor reactions at guided tours with personal instructions are evaluated. Data on perception of realism, spatial quality and light in the VR model were collected with qualitative...

  9. Footprints of China Auto Internatienal Exhibition Tour

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ November 2008,the Sixth China Auto International(Algeria & Egypt)Exhibition Tour is ready.Since the first session was held in 1995,the Chinese auto enterprises have been to Vietnam,Cambodia,Syria,and Russian.

  10. France at CERN – Industrial exhibition

    CERN Multimedia

    FP Department

    2012-01-01

    Industrial Exhibition Administration Building Bldg 61 – 1st Floor Tuesday 27 March: 9 a.m. – 5.30 p.m. Wednesday 28 March: 9 a.m. – 2 p.m.   About thirty French companies are presenting their latest technological advances during the industrial exhibition "France at CERN", featuring products and technologies specifically related to CERN activities. Individual B2B meetings can be organized with the sales and technical representatives of participating firms and will take place at either the companies’ exhibition stands or in conference rooms in the Main Building. Individuals wishing to make contact with one or more companies must use the contact details available from each secretariat of department or by using this link. B2B meetings will be coordinated by UBIFRANCE. You will also find the list of exhibiting and participating companies online here. This event is sponsored by the French subsidiary of RS Components, the most important distri...

  11. 49 CFR 250.2 - Required exhibits.

    Science.gov (United States)

    2010-10-01

    ... and detail for Class II railroads. (14) As Exhibit 14, a statement showing actual cash balance at the beginning of each month and the actual cash receipts and disbursements during each month of the current...

  12. Exhibition 2004: Never-falling Stand

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    Another year for reform and development Reform and development, key words and melodies for present life, may reflect future changes definitely. Rapid progress of convention & exhibition industry undoubtedly predicates future development of this industry in China.

  13. The Report of Virtual Exhibition Software Development

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The main structure and key techniques of our Vir tual ExhibitionSoftware are summarized. It demonstrates the practice of Softwa re Engineering during the development of our project and discusses the use of UML in it.

  14. Waves in geomaterials exhibiting negative stiffness behaviour

    Science.gov (United States)

    Esin, Maxim; Dyskin, Arcady; Pasternak, Elena

    2016-04-01

    Negative stiffness denotes the type of material behaviour when the force applied to the body decreases the body's deformation increases. Some geomaterials, for instance, rocks, demonstrate behaviour of this type at certain loads: during the compression tests the loading curves exhibit descending branch (post-peak softening). One of the possible mechanisms of the negative stiffness appearance in geomaterials is rotation of non-spherical grains. It is important to emphasize that in this case the descending branch may be reversible given that the testing machine is stiff enough (in general case it means an importance of boundary conditions). Existence of geomaterials with a negative modulus associated with rotations may have significant importance. In particular, important is understanding of the wave propagation in such materials. We study the stability of geomaterials with negative stiffness inclusions and wave propagation in it using two approaches: Cosserat continuum and discrete mass-spring models. In both cases we consider the rotational degrees of freedom in addition to the conventional translational ones. We show that despite non positiveness of the energy the materials with negative stiffness elements can be stable if certain conditions are met. In the case of Cosserat continuum the Cosserat shear modulus (the modulus relating the non-symmetrical part of shear stress and internal rotations) is allowed to assume negative values as long as its value does not exceed the value of the standard (positive) shear modulus. In the case of discrete mass-spring systems (with translational and rotational springs) the concentration of negative stiffness springs and the absolute values of negative spring stiffness are limited. The critical concentration when the system loses stability and the amplitude of the oscillations tends to infinity is equal to 1/2 and 3/5 for two- and three-dimensional cases respectively.

  15. Reaching the Public through Traveling Exhibitions

    Science.gov (United States)

    Dusenbery, P. B.; Harold, J. B.; Morrow, C. A.

    2004-11-01

    The Space Science Institute (SSI) of Boulder, Colorado has recently developed two museum exhibits called Alien Earths and MarsQuest. It has just started to develop another exhibit called Giant Planets. These exhibitions provide research scientists the opportunity to engage in a number of activities that are vital to the success of these major outreach programs. Alien Earths was developed in partnership with various research missions. The focus of the presentation will be on MarsQuest and Giant Planets. MarsQuest is a 5000 square-foot, \\$3M, traveling exhibition that is now touring the country. The exhibit's second 3-year tour will enable millions of Americans to share in the excitement of the scientific exploration of Mars and learn more about their own planet in the process. The associated planetarium show and education program will also be described, with particular emphasis on workshops to orient museum staff (e.g. museum educators and docents) and workshops for master educators near host museums and science centers. The workshops make innovative connections between the exhibition's interactive experiences and lesson plans aligned with the National Science Education Standards. These exhibit programs are good models for actively involving scientists and their discoveries to help improve informal science education in the museum community and for forging a stronger connection between formal and informal education. The presentation will also discuss how Giant Planets, a proposed 3500 square-foot traveling exhibition on the mysteries and discoveries of the outer planets, will be able to take advantage of the connections and resources that have been developed by the MarsQuest project.

  16. An Astrobiology Microbes Exhibit and Education Module

    Science.gov (United States)

    Lindstrom, Marilyn M.; Allen, Jaclyn S.; Stocco, Karen; Tobola, Kay; Olendzenski, Lorraine

    2001-01-01

    Telling the story of NASA-sponsored scientific research to the public in exhibits is best done by partnerships of scientists and museum professionals. Likewise, preparing classroom activities and training teachers to use them should be done by teams of teachers and scientists. Here we describe how we used such partnerships to develop a new astrobiology augmentation to the Microbes! traveling exhibit and a companion education module. "Additional information is contained in the original extended abstract."

  17. When Do Children Exhibit a "Yes" Bias?

    Science.gov (United States)

    Okanda, Mako; Itakura, Shoji

    2010-01-01

    This study investigated whether one hundred and thirty-five 3- to 6-year-old children exhibit a yes bias to various yes-no questions and whether their knowledge status affects the production of a yes bias. Three-year-olds exhibited a yes bias to all yes-no questions such as "preference-object" and "knowledge-object" questions pertaining to…

  18. Exhibition by Gozitan artist Mark Sagona

    OpenAIRE

    Calleja, Joseph

    2004-01-01

    Mark Sagona's exhibition, entitled "Recent Insights" was held at the Banca Giuratale in Victoria, Gozo between the 24th January and the 8th February 2004. It brought together twenty-four paintings, all produced in 2003 and the majority of which were realised in oil on canvas. The exhibition was curated by Dr Joseph Paul Cassar, and inaugurated by the Minister for Gozo, the Hon. Giovanna Debono.

  19. Science, providence, and progress at the Great Exhibition.

    Science.gov (United States)

    Cantor, Geoffrey

    2012-09-01

    The Great Exhibition of 1851 is generally interpreted as a thoroughly secular event that celebrated progress in science, technology, and industry. In contrast to this perception, however, the exhibition was viewed by many contemporaries as a religious event of considerable importance. Although some religious commentators were highly critical of the exhibition and condemned the display of artifacts in the Crystal Palace as giving succor to materialism, others incorporated science and technology into their religious frameworks. Drawing on sermons, tracts, and the religious periodical press, this essay pays close attention to the ways in which science and technology were endowed with providentialist significance and particularly examines the notion of human progress used by a number of Christian writers, especially Congregationalists, who set scientific and technological progress within a teleological religious perspective. This discussion sheds fresh light not only on the Great Exhibition itself but also on the deployment of natural theology in mid-nineteenth-century Britain.

  20. Evaluation of Antimicrobial Activity of Root Extracts of Abitulon indicum

    Directory of Open Access Journals (Sweden)

    Krishna Rao MORTHA

    2015-06-01

    Full Text Available Antimicrobial activity of Abitulon indicum roots was studied against seven pathogenic bacteria and three fungal strains by agar well diffusion method. Antimicrobial activity was recorded for hexane, chloroform, methanol, ethanol and aqueous extracts. Alcohol (ethanol and methanol extracts exhibited the highest degree of antimicrobial activity compared to aqueous, chloroform and hexane extracts. Pseudomonas aeruginosa was turned out to be the most susceptible bacterium to the crude root chemical constituents, using the standard Tetracycline and Clotrimazole. Minimum inhibition concentration values of hexane, chloroform, methanol, ethanol and aqueous extracts were determined by the agar dilution method and ranged between 62.5 and 1,000 µg. The study suggested that the root extracts possess bioactive compounds with antimicrobial activity against the tested bacteria and fungi, revealing a significant scope to develop a novel broad spectrum of antimicrobial drug formulation from Abitulon indicum.

  1. Toxicity and Antioxidant Tests of Morinda citrifolia (noni Seed Extract

    Directory of Open Access Journals (Sweden)

    Brett J. West

    2011-08-01

    Full Text Available The aim of the current study was to evaluate Morinda citrifolia (noni seed extract, a food ingredient, for potential toxicity and antioxidant activity. Nitrates, nitrites, phytic acid, oxalic acid, as well as aflatoxins B1, B2, G1 and G2 were not detected in the extract. The extract was also non-cytoxic (LC50 > 1 mg/mL in the 24 and 40 h brine shrimp toxicity test. There were no symptoms of toxicity in a subacute (28 day oral toxicity test in Sprague-Dawley rats. Noni seed extract did not display any genotoxic potential in a primary DNA damage test in E. coli PQ37. The extract did exhibit significant antioxidant activity in the Oxygen Radical Absorbance Capacity (ORAC and Ferric Reducing Antioxidant Power (FRAP tests.

  2. Frequency of orthodontic extraction

    Directory of Open Access Journals (Sweden)

    Camila de S. Dardengo

    2016-02-01

    Full Text Available Introduction: The option of dental extraction for orthodontic purposes has been debated for more than 100 years, including periods when it was widely used in treatment, including the present, during which other methods are used to avoid dental extractions. The objective was to analyze the frequency of tooth extraction treatment performed between 1980 and 2011 at the Orthodontic Clinic of Universidade Estadual do Rio de Janeiro (UERJ. Material and Methods: The clinical records of 1484 patients undergoing orthodontic treatment were evaluated. The frequency of extractions was evaluated with regard to sex, Angle's classification, the different combinations of extractions and the period when orthodontic treatment began. Chi-square test was used to determine correlations between variables, while the chi-square test for trends was used to assess the frequency of extractions over the years. Results: There was a reduction of approximately 20% in the frequency of cases treated with tooth extraction over the last 32 years. The most frequently extracted teeth were first premolars. Patients with Class I malocclusion showed fewer extractions, while Class II patients underwent a higher number of extraction treatment. There were no statistically significant differences with regard to sex. Conclusion: New features introduced into the orthodontic clinic and new esthetic concepts contributed to reducing the number of cases treated with dental extractions. However, dental extractions for orthodontic purposes are still well indicated in certain cases.

  3. Chemical constituents and anti-tuberculosis activity of ink extracts of cuttlefish, Sepiella inermis

    Institute of Scientific and Technical Information of China (English)

    Muthusamy Ravichandiran; Selvam Thiripurasalini; Vaithilingam Ravitchandirane; Srinivasa Gopalane; Chelladurai Stella

    2013-01-01

    Objective: To study the chemical constituents and the anti-tuberculosis activity of methanol and chloroform ink extracts of Sepiella inermis.Methods:Chemical analysis was carried out by UV-VIS spectrophotometer, FT-IR and GC-MS. Crude extracts Pulverized ink powder was extracted separately with chloroform and methanol. were tested in vitro for their activity against Mycobacterium tuberculosis using Lowenstein Jensen (L-J) medium. Activity in L-J medium was assessed by mean reduction in number of colonies on extract containing bottles as compared to extract free controls.Results:octadecadienoic acid, 9-octadecenoic acid and octadecanoic acid. The chloroform extract GC-MS of methanol extract revealed four compounds viz. hexadecanoic acid, 9, 12-containing fourteen compounds. The methanol extract exhibited anti-tuberculosis activity in L-J medium at 64 µg/mL with the observed inhibition of 14 CFU. Chloroform extract displayed a weak activity against Mycobacterium tuberculosis.Conclusions:Mycobacterium tuberculosis than chloroform extract. Since ink of sepia is available abundantly as This investigation showed the methanol extract exhibited significant activity against a waste material, further studies aimed at isolation and efficacy of active substances pave the way for new anti-tuberculosis drugs.

  4. Chemical constituents and anti-tuberculosis activity of ink extracts of cuttlefish, Sepiella inermis

    Directory of Open Access Journals (Sweden)

    Muthusamy Ravichandiran

    2013-11-01

    Full Text Available Objective: To study the chemical constituents and the anti-tuberculosis activity of methanol and chloroform ink extracts of Sepiella inermis. Methods: Pulverized ink powder was extracted separately with chloroform and methanol. Chemical analysis was carried out by UV-VIS spectrophotometer, FT-IR and GC-MS. Crude extracts were tested in vitro for their activity against Mycobacterium tuberculosis using Lowenstein Jensen (L-J medium. Activity in L-J medium was assessed by mean reduction in number of colonies on extract containing bottles as compared to extract free controls. Results: GC-MS of methanol extract revealed four compounds viz. hexadecanoic acid, 9, 12- octadecadienoic acid, 9-octadecenoic acid and octadecanoic acid. The chloroform extract containing fourteen compounds. The methanol extract exhibited anti-tuberculosis activity in L-J medium at 64 µg/mL with the observed inhibition of 14 CFU. Chloroform extract displayed a weak activity against Mycobacterium tuberculosis. Conclusions: This investigation showed the methanol extract exhibited significant activity against Mycobacterium tuberculosis than chloroform extract. Since ink of sepia is available abundantly as a waste material, further studies aimed at isolation and efficacy of active substances pave the way for new anti-tuberculosis drugs.

  5. CERN exhibition a big hit in Bulgaria

    CERN Multimedia

    2005-01-01

    The first CERN exhibition in Bulgaria attracted many visitors. In the first ever CERN exhibition to be held in Bulgaria, over 1,400 visitors, many of them students and young physicists, visited the 10-day event in Sofia. The CERN mini-exhibition took place at the National Earth and Mankind Museum between 8 and 17 November. Permanently staffed by young physicists from Sofia University, there were exhibits on display about research activities at CERN, as well as four additional posters describing Bulgaria's participation. The inauguration took place on the morning of 8 November in the presence of the Vice-Minister for Science and Education, Mrs. Vanya Dobreva, and some 200 guests. A series of short speeches were followed by a visit to the exhibition. CERN's representative at the event, Ray Lewis, was then asked by Professor Matey Mateev, President of the Union of Physicists in Bulgaria, to say a few words on behalf of the Organization. Numerous journalists were also present at the inauguration. A painting enti...

  6. The Comparative Analysis of Antioxidant and Biological Activity for the Dendropanax morbifera LEV. Leaves Extracted by Different Ethanol Concentrations.

    Science.gov (United States)

    Nakamura, Masaya; Ra, Jong-Hwan; Kim, Ju-Sung

    2016-01-01

    The different concentrations of ethanol (20-100%) and distilled water extract for Dendropanax morbifera LEV. leaves were evaluated to induce antioxidant and biological activity employed by variety of assays. The 20%, 80%, and 100% ethanol extract demonstrated the relatively higher activity, whereas distilled water, 40%, and 60% ethanol extracts exhibited the lower antioxidant and biological activity. Especially, 80% ethanol extract showed the remarkably higher radical scavenging activity, reducing power, total phenol and flavonoid content, α-glucosidase, and tyrosinase inhibitory activity, and alcohol dehydrogenases (ADH) and aldehyde dehydrogenase (ALDH) activity. Also, 100% ethanol extract exhibited relatively greater activity, but there did not show significant radical scavenging activity. Furthermore, there were 50% and 30% promotion effect for ADH activity assay and 80% and 40% promotion effect for ALDH activity assay in 80% and 100% ethanol extract, respectively. In addition, in the minimum inhibitory concentration (MIC), all extracts except for distilled water extract inhibited Bacillus cereus, Staphylococcus aureus subsp. aureus, Escherichia coli. For Pichia jadinii, whole extracts effectively inhibited yeast multiplication at concentration of 125 μg/mL for 100% ethanol extract and 250 μg/mL for the rest of extract. These result indicated that D. morbifera LEV. leaves extracted by 80% ethanol would be the ideal extracting solution to maximize inherent antioxidant and biological activity agent.

  7. Antiviral activity and mode of action of propolis extracts and selected compounds.

    Science.gov (United States)

    Schnitzler, Paul; Neuner, Annett; Nolkemper, Silke; Zundel, Christine; Nowack, Hans; Sensch, Karl Heinz; Reichling, Jürgen

    2010-01-01

    Aqueous and ethanol extracts of propolis were analysed phytochemically and examined for their antiviral activity in vitro. Different polyphenols, flavonoids and phenylcarboxylic acids were identified as major constituents. The antiviral effect of propolis extracts and selected constituents, e.g. caffeic acid (1), p-coumaric acid (2), benzoic acid (3), galangin (4), pinocembrin (5) and chrysin (6) against herpes simplex virus type 1 (HSV-1) was analysed in cell culture. The 50% inhibitory concentration (IC(50)) of aqueous and ethanol propolis extracts for HSV-1 plaque formation was determined at 0.0004% and 0.000035%, respectively. Both propolis extracts exhibited high levels of antiviral activity against HSV-1 in viral suspension tests, plaque formation was significantly reduced by >98%. In order to determine the mode of antiviral action of propolis, the extracts were added at different times during the viral infection cycle. Both propolis extracts exhibited high anti-HSV-1 activity when the viruses were pretreated with these drugs prior to infection. Among the analysed compounds, only galangin and chrysin displayed some antiviral activity. However, the extracts containing many different components exhibited significantly higher antiherpetic effects as well as higher selectivity indices than single isolated constituents. Propolis extracts might be suitable for topical application against herpes infection.

  8. Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines

    Institute of Scientific and Technical Information of China (English)

    Soundararajan Vijayarathna; Sreenivasan Sasidharan

    2012-01-01

    To investigate the cytotoxic effect of Elaeis guineensis methanol extract on MCF-7 and Vero cell. Methods: In vitro cytotoxicity was evaluated in by MTT assay. Cell morphological changes were observed by using light microscope. Results: The MTT assay indicated that methanol extract of the plant exhibited significant cytotoxic effects on MCF-7. Morphological alteration of the cell lines after exposure with Elaeis guineensis extract were observed under phase contrast microscope in the dose dependent manner. Conclusions: The results suggest the probable use of the Elaeis guineensis methanol extract in preparing recipes for cancer-related ailments. Further studies on isolation of metabolites and their in vivo cytotoxicity are under investigation.

  9. Cytotoxicity of methanol extracts of Elaeis guineensis on MCF-7 and Vero cell lines.

    Science.gov (United States)

    Vijayarathna, Soundararajan; Sasidharan, Sreenivasan

    2012-10-01

    To investigate the cytotoxic effect of Elaeis guineensis methanol extract on MCF-7 and Vero cell. In vitro cytotoxicity was evaluated in by MTT assay. Cell morphological changes were observed by using light microscope. The MTT assay indicated that methanol extract of the plant exhibited significant cytotoxic effects on MCF-7. Morphological alteration of the cell lines after exposure with Elaeis guineensis extract were observed under phase contrast microscope in the dose dependent manner. The results suggest the probable use of the Elaeis guineensis methanol extract in preparing recipes for cancer-related ailments. Further studies on isolation of metabolites and their in vivo cytotoxicity are under investigation.

  10. Anthropological significance of phenylketonuria.

    Science.gov (United States)

    Saugstad, L F

    1975-01-01

    The highest incidence rates of phenylketonuria (PKU) have been observed in Ireland and Scotlant. Parents heterozygous for PKU in Norway differ significantly from the general population in the Rhesus, Kell and PGM systems. The parents investigated showed an excess of Rh negative, Kell plus and PGM type 1 individuals, which makes them similar to the present populations in Ireland and Scotlant. It is postulated that the heterozygotes for PKU in Norway are descended from a completely assimilated sub-population of Celtic origin, who came or were brought here, 1ooo years ago. Bronze objects of Western European (Scottish, Irish) origin, found in Viking graves widely distributed in Norway, have been taken as evidence of Vikings returning with loot (including a number of Celts) from Western Viking settlements. The continuity of residence since the Viking age in most habitable parts of Norway, and what seems to be a nearly complete regional relationship between the sites where Viking graves contain western imported objects and the birthplaces of grandparents of PKUs identified in Norway, lend further support to the hypothesis that the heterozygotes for PKU in Norway are descended from a completely assimilated subpopulation. The remarkable resemblance between Iceland and Ireland, in respect of several genetic markers (including the Rhesus, PGM and Kell systems), is considered to be an expression of a similar proportion of people of Celtic origin in each of the two countries. Their identical, high incidence rates of PKU are regarded as further evidence of this. The significant decline in the incidence of PKU when one passes from Ireland, Scotland and Iceland, to Denmark and on to Norway and Sweden, is therefore explained as being related to a reduction in the proportion of inhabitants of Celtic extraction in the respective populations.

  11. The exploration of the exhibition informatization

    Science.gov (United States)

    Zhang, Jiankang

    2017-06-01

    The construction and management of exhibition informatization is the main task and choke point during the process of Chinese exhibition industry’s transformation and promotion. There are three key points expected to realize a breakthrough during the construction of Chinese exhibition informatization, and the three aspects respectively are adopting service outsourcing to construct and maintain the database, adopting advanced chest card technology to collect various kinds of information, developing statistics analysis to maintain good cutomer relations. The success of Chinese exhibition informatization mainly calls for mature suppliers who can provide construction and maintenance of database, the proven technology, a sense of data security, advanced chest card technology, the ability of data mining and analysis and the ability to improve the exhibition service basing on the commercial information got from the data analysis. Several data security measures are expected to apply during the process of system developing, including the measures of the terminal data security, the internet data security, the media data security, the storage data security and the application data security. The informatization of this process is based on the chest card designing. At present, there are several types of chest card technology: bar code chest card; two-dimension code card; magnetic stripe chest card; smart-chip chest card. The information got from the exhibition data will help the organizers to make relevant service strategies, quantify the accumulated indexes of the customers, and improve the level of the customer’s satisfaction and loyalty, what’s more, the information can also provide more additional services like the commercial trips, VIP ceremonial reception.

  12. Exhibits in libraries a practical guide

    CERN Document Server

    Brown, Mary E

    2005-01-01

    "Ccomprehensive...detailed"--Booklist; "thoroughly reseached...highly recommended"--Journal of Access Services. Library exhibits are more than entertainment for patrons. They can inspire and educate, stimulate an interest that can be explored in a book, or attract visitors who otherwise wouldn't stop by. Displays are also an opportunity for a library to put its creative foot forward or help patrons navigate the facility itself. This comprehensive "how-to" includes everything a librarian or staff member needs to know to put on an exhibit, from hatching ideas to evaluating the end result. Illustrations and photographs show practical methods of planning, labeling and displaying.

  13. A new MOF-505 analog exhibiting high acetylene storage.

    Science.gov (United States)

    Hu, Yunxia; Xiang, Shengchang; Zhang, Wenwei; Zhang, Zhuxiu; Wang, Lei; Bai, Junfeng; Chen, Banglin

    2009-12-28

    A new microporous metal-organic framework Cu(2)(EBTC)(H(2)O)(2) x xG (EBTC = 1,1'-ethynebenzene-3,3',5,5'-tetracarboxylate; G = guest molecule) was rationally designed with a NbO net, exhibiting significantly high acetylene storage of 252 and 160 cm(3) g(-1) at 273 and 295 K under 1 bar, respectively.

  14. Dolichos biflorus exhibits anti-inflammatory and antioxidant properties in an acute inflammatory model

    Directory of Open Access Journals (Sweden)

    Limi Elizabeth Mathew

    2014-12-01

    Full Text Available Dolichos biflorus (Muthira is a branched, suberect, and downing herb, native to most parts of India, and found at altitudes of up to 1000 m, whose seeds can be cooked and eaten. Nutrition plays a key role in building immunity and preventing noncommunicable diseases to a certain extent. The purpose of this study was to evaluate the anti-inflammatory and antioxidant effects of 70% methanolic extract of seeds of D. biflorus (DME in carrageenan-induced inflammation. DME exhibited maximum percentage of oedema inhibition at a dose of 50 mg/kg at the 3rd hour of carrageenan induction. The effect was higher than that of the standard drug Voveran. The activities of cyclooxygenase, lipoxygenase, nitric oxide synthase, myeloperoxidase, and malondialdehyde showed significant (p < 0.05 reduction whereas the activities of antioxidant enzymes, vitamins C, and reduced glutathione level were increased significantly (p < 0.05 on treatment with DME. Also levels of the acute phase protein, ceruloplasmin, were brought to their normal range in DME-treated rats. Phytochemical analysis showed that the extract contains alkaloids, flavonoids, carbohydrates, proteins, and tannins, which may contribute to its anti-inflammatory and antioxidant activity. Thus the results demonstrate the potential beneficiary effect of DME on carrageenan-induced inflammation in rats.

  15. Efficient solvent extraction of antioxidant-rich extract from a tropical diatom,Chaetoceros calcitrans (Paulsen) Takano 1968

    Institute of Scientific and Technical Information of China (English)

    Su Chern Foo; Fatimah Md Yusoff; Maznah Ismail; Mahiran Basri; Nicholas Mun Hoe Khong; Kim Wei Chan; Sook Kun Yau

    2015-01-01

    Objective:To compare thein vitro antioxidant capacity of a diatom,Chaetoceros calcitrans (C. calcitrans) extracted using six types of solvents. Methods:Each extract was evaluated in terms of extraction yield, total carotenoid, fucoxanthin content, total phenolic and antioxidant capacities (DPPH• andABTS•+ scavenging activity and iron chelating activity). Results: The methanol extract exhibited the highest yield [(22.71 ± 0.96) g/100 g dry weight (DW)], total carotenoid [(4.46 ± 0.36) mg/g DW], total phenolic [(2.49 ± 0.08) mg gallic acid equivalents/g DW] and second highest fucoxanthin content [(2.08 ± 0.03) mg fucoxanthin/g DW] as compared to other solvent extracts. Methanolic extract also exhibited significantly higher (P Conclusions: Methanol was the recommended solvent for the production of antioxidant rich extract fromC. calcitrans. Both carotenoids and phenolic acids were found to be positively correlated to the antioxidant capacities ofC. calcitrans. Lead bioactives confirmed by subsequent high performance liquid chromatography studies were fucoxanthin, gallic acid and protocatechuic acid.

  16. Efficient solvent extraction of antioxidant-rich extract from a tropical diatom,Chaetoceros calcitrans (Paulsen) Takano 1968简

    Institute of Scientific and Technical Information of China (English)

    Su; Chern; Foo; Fatimah; Md.Yusoff; Maznah; Ismail; Mahiran; Basri; Nicholas; Mun; Hoe; Khong; Kim; Wei; Chan; Sook; Kun; Yau

    2015-01-01

    Objective: To compare the in vitro antioxidant capacity of a diatom, Chaetoceros calcitrans(C. calcitrans) extracted using six types of solvents.Methods: Each extract was evaluated in terms of extraction yield, total carotenoid,fucoxanthin content, total phenolic and antioxidant capacities(DPPH and ABTS +scavenging activity and iron chelating activity).Results: The methanol extract exhibited the highest yield [(22.71 ± 0.96) g/100 g dry weight(DW)], total carotenoid [(4.46 ± 0.36) mg/g DW], total phenolic [(2.49 ± 0.08) mg gallic acid equivalents/g DW] and second highest fucoxanthin content [(2.08 ± 0.03) mg fucoxanthin/g DW] as compared to other solvent extracts. Methanolic extract also exhibited significantly higher(P < 0.05) scavenging(DPPH, ABTS +) and iron chelating activities.Conclusions: Methanol was the recommended solvent for the production of antioxidant rich extract from C. calcitrans. Both carotenoids and phenolic acids were found to be positively correlated to the antioxidant capacities of C. calcitrans. Lead bioactives confirmed by subsequent high performance liquid chromatography studies were fucoxanthin, gallic acid and protocatechuic acid.

  17. Efficacy of an aqueous Pelargonium sidoides extract against herpesvirus.

    Science.gov (United States)

    Schnitzler, P; Schneider, S; Stintzing, F C; Carle, R; Reichling, J

    2008-12-01

    The compounds of an aqueous root extract of the African medicinal plant Pelargonium sidoides were analysed by LC-MS spectroscopy and the antiviral effect of this extract against herpes simplex virus was examined in cell culture. Besides predominant coumarins, simple phenolic structures as well as flavonoid and catechin derivatives were identified as major constituents in the Pelargonium extract. The inhibitory activity of this extract against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) was tested in vitro on RC-37 cells using a plaque reduction assay and exhibited high antiviral activity against both herpesviruses in viral suspension tests. The 50% inhibitory concentration (IC(50)) of the aqueous Pelargonium sidoides extract for herpes simplex virus plaque formation was determined at 0.00006% and 0.000005% for HSV-1 and HSV-2, respectively. At maximum noncytotoxic concentrations of the extract, plaque formation was significantly reduced by more than 99.9% for HSV-1 and HSV-2 and a clear concentration-dependent antiviral activity against HSV could be demonstrated for this extract. In order to determine the mode of antiviral action, the extract was added at different times to the cells or viruses during the infection cycle. Both herpesviruses were significantly inhibited when pretreated with the plant extract or when the extract was added during the adsorption phase, whereas acyclovir demonstrated antiviral activity only intracellularly during replication of HSV. These results indicate that P. sidoides extract affected the virus before penetration into the host cell and reveals a different mode of action when compared to the classical drug acyclovir. Hence this extract is capable of exerting an antiviral effect on herpes simplex virus and might be suitable for topical therapeutic use as antiviral drug both in labial and genital herpes infection.

  18. How do exhibition visitors describe aesthetic qualities?

    DEFF Research Database (Denmark)

    Thomsen, Bente Dahl; Ravn, Anders Peter

    2007-01-01

    In this investigation, visitors to an art and design exhibition have used an interactive computer program to express the qualities they consider important for an art or design object (artefact). They have then used the program with their individually selected qualities to assess the artefacts. In...

  19. Autoimmune pancreatitis exhibiting multiple mass lesions.

    Science.gov (United States)

    Shiokawa, Masahiro; Kodama, Yuzo; Hiramatsu, Yukiko; Kurita, Akira; Sawai, Yugo; Uza, Norimitsu; Watanabe, Tomohiro; Chiba, Tsutomu

    2011-09-01

    Our case is a first report of autoimmune pancreatitis with multiple masses within the pancreas which was pathologically diagnosed by endoscopic ultrasound-guided fine needle aspiration and treated by steroid. The masses disappeared by steroid therapy. Our case is informative to know that autoimmune pancreatitis sometimes exhibits multiple masses within the pancreas and to diagnose it without unnecessary surgery.

  20. Autoimmune Pancreatitis Exhibiting Multiple Mass Lesions

    Directory of Open Access Journals (Sweden)

    Masahiro Shiokawa

    2011-09-01

    Full Text Available Our case is a first report of autoimmune pancreatitis with multiple masses within the pancreas which was pathologically diagnosed by endoscopic ultrasound-guided fine needle aspiration and treated by steroid. The masses disappeared by steroid therapy. Our case is informative to know that autoimmune pancreatitis sometimes exhibits multiple masses within the pancreas and to diagnose it without unnecessary surgery.

  1. CERN exhibition wins yet another design prize

    CERN Multimedia

    Joannah Caborn Wengler

    2012-01-01

    The “Universe of Particles” exhibition in CERN’s Globe wins the silver design prize from the German direct business communications association FAMAB.   Not only do tens of thousands of people visit the “Universe of Particles” exhibition each year, but juries for design prizes are crossing its threshold more and more frequently too. In 2011 alone it claimed 8 awards, including winning outright the 2011 Annual Multimedia award, the iF Communication Design for Corporate Architecture award and the Modern Decoration Media award (the Bulletin already reported on some of these in July 2011). The FAMAB award is the latest to join the prestigious list. The jury of FAMAB’s “ADAM 2011” award was particularly impressed by the hands-on nature of the exhibition, which encourages visitors to get interested in science. They also appreciated the way that the space in the Globe is not just a container for the exhibits, but itself ...

  2. Comic Strips to Accompany Science Museum Exhibits

    Science.gov (United States)

    Chung, Beom Sun; Park, Eun-mi; Kim, Sang-Hee; Cho, Sook-kyoung; Chung, Min Suk

    2016-01-01

    Science museums make the effort to create exhibits with amusing explanations. However, existing explanation signs with lengthy text are not appealing, and as such, visitors do not pay attention to them. In contrast, conspicuous comic strips composed of simple drawings and humors can attract science museum visitors. This study attempted to reveal…

  3. 18 CFR 50.7 - Applications: exhibits.

    Science.gov (United States)

    2010-04-01

    ... data that represent system operating conditions. (i) Exhibit I—Project Cost and Financing. (1) A statement of estimated costs of any new construction or modification. (2) The estimated capital cost and...) Provide all files to model normal, single contingency, multiple contingency, and special...

  4. 32 CFR 705.24 - Exhibits.

    Science.gov (United States)

    2010-07-01

    ..., or similar events. Also included are general purpose displays in public buildings or public locations... support local Navy recruiters. Requests for exhibits for community relations events will be considered... event). (2) The office of the Assistant Secretary of Defense (Public Affairs) is the approving authority...

  5. 18 CFR 34.4 - Required exhibits.

    Science.gov (United States)

    2010-04-01

    ... Cash Flows must be in the form prescribed for the “Statement of Cash Flows” of the FERC Form No. 1... Cash Flows and Computation of Interest Coverage on an actual basis and a pro forma basis for the most... the statement of corporate purposes from its articles of incorporation. (b) Exhibit B. A copy of all...

  6. CCPIT Machinery Exhibition Succeeded in Kuala Lumpur

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

      From August 18 to 20, 2005, China Council for the Promotion of International Trade(CCPIT) held China Machinery and Electronics Trade Exhibition, CME 2005 in Kuala Lumpur, the capital of Malaysia on behalf of China, a good job has been done.……

  7. CCPIT Machinery Exhibition Succeeded in Kuala Lumpur

    Institute of Scientific and Technical Information of China (English)

    2005-01-01

    @@ From August 18 to 20, 2005, China Council for the Promotion of International Trade(CCPIT) held China Machinery and Electronics Trade Exhibition, CME 2005 in Kuala Lumpur, the capital of Malaysia on behalf of China, a good job has been done.

  8. Exhibition Ethics - An Overview of Major Issues

    Directory of Open Access Journals (Sweden)

    Andromache Gazi

    2014-05-01

    Full Text Available Museum ethics are about value judgements. In making such judgements museum personnel is constantly valuing one option over another. This holds true for every aspect of museum work; from collecting policies and conservation to store priorities and exhibition. In recent decades there has been a growing concern in addressing ethical issues in museums as museum workers have developed cultural sensitivity and social responsiveness to a degree unseen before. Most codes of ethics urge museums to give appropriate consideration to represented groups or beliefs. In light of this, it has been recognised that exhibition of sensitive material, for example, must be done with great tact and respect for the feelings of religious, ethnic or other groups represented. Another issue concerns the display of unprovenanced material and repatriation. Yet, these are not the only ethical issues which exhibition developers are faced with. As museum workers we should constantly be reminded that exhibitions are active agents in the construction of knowledge. This paper discusses the hidden assumptions on which museum presentation and interpretation are often based. Decisions about what to include and what to exclude, what is valued and what is not, the means of presentation, language, and so on, all lead to presentational styles which may shape the public’s perception in unintended ways.

  9. Retrospect of China International Auto Exhibition Tours

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ "Fengfan Cup" the Frist China International Auto Exhibition Tour In 1995, the first session gathered 28 national motorcycles and autos from four big groups---China North Industries Group Corporation, China Aviation Industry Corporation, China Aerospace Science and Industry Cooperation and PLA General Logistics Department.

  10. Do Online Students Exhibit Different Learning Styles?

    Science.gov (United States)

    Hausler, Joel; Sanders, John W.; Young, Barbara

    2007-01-01

    Do online students exhibit different learning styles from onsite students; and if so, what accommodations relating to learning style differences may be made for online students? Our ideas of best practices within this area have been evolving to keep up with our students. Various tactics have been used to make sure students understand what kinds of…

  11. Do Online Students Exhibit Different Learning Styles

    Science.gov (United States)

    Hausler, Joel; Sanders, John W.; Young, Barbara

    2007-01-01

    We examined the relationship between learning styles and student type. This research seeks to examine if online students exhibit different learning styles from onsite students; and, if so, what accommodations relating to learning style differences may be made for online students? Students (N = 80) were asked to complete an online survey in order…

  12. The potential of papaya leaf extract in controlling Ganoderma boninense

    Science.gov (United States)

    Tay, Z. H.; Chong, K. P.

    2016-06-01

    Basal Stem Rot (BSR) disease causes significant losses to the oil palm industry. Numerous controls have been applied in managing the disease but no conclusive result was reported. This study investigated the antifungal potential of papaya leaf extracts against Ganoderma boninense, the causal pathogen of BSR. Among the five different solvents tested in extraction of compounds from papaya leaf, methanol and acetone gave the highest yield. In vitro antifungal activity of the methanol and acetone extracts were evaluated against G. boninense using agar dilution at four concentrations: 5 mg mL-1, 15 mg mL-1, 30 mg mL-1and 45 mg mL-1. The results indicated a positive correlation between the concentration of leaf extracts and the inhibition of G. boninense. ED50 of methanol and acetone crude extracts were determined to be 32.016 mg mL-1and 65.268 mg mL-1, respectively. The extracts were later semi-purified using solid phase extraction (SPE) and the nine bioactive compounds were identified: decanoic acid, 2-methyl-, Z,Z-10-12-Hexadecadien-1-ol acetate, dinonanoin monocaprylin, 2-chloroethyl oleate, phenol,4-(1-phenylethyl)-, phenol,2,4-bis(1-phenylethyl)-, phenol-2-(1-phenylethyl)-, ethyl iso-allocholate and 1- monolinoleoylglycerol trimethylsilyl ether. The findings suggest that papaya leaf extracts have the ability to inhibit the growth of G. boninense, where a higher concentration of the extract exhibits better inhibition effects.

  13. EVALUATION OF ANALGESIC ACTIVITY OF LEPIDAGATHIS CRISTATA WILLD LEAF EXTRACTS

    Directory of Open Access Journals (Sweden)

    Purma Aravinda Reddy

    2013-04-01

    Full Text Available Aim of the study is to screen the Lepidagathis cristata Willd, leaf extracts for analgesic activity, because the plant was screened only for immunosuppressive, antipyretic activities only, now in the present study the analgesic activity of leaf extracts were performed. The ethanolic, ethyl acetate, chloroform extracts were prepared and are used for analgesic activity in two dose level that is 200 and 400 mg/kg body weight per oral in two screening methods, one is Hot Plate (n=5, another is Tail Immersion method (n=5, and the leaf extracts are showed significant analgesic activity. The plant extracts did not exhibit any mortality up to the dose level 4000 mg/kg. The methanol, Chloroform and Ethyl acetate extracts of leaf was evaluated for analgesic activity. . The 400mg/kg dose of leaf chloroform extract has highest activity in both the experimental models with 62.5% protection after 30min and 47.3% after 60 min with the significance of p< 0.001 when compared with 0 time interval and after 90 min it was shown 50% of protection and all the extracts has graded dose response.

  14. In vivo potential hypoglycemic and in vitro vasorelaxant effects of Cecropia glazioviistandardized extracts

    Directory of Open Access Journals (Sweden)

    Daniela Paula Arend

    2015-10-01

    Full Text Available ABSTRACTThe aim of this study is to investigate the effect of Cecropia glaziovii Snethl, Urticaceae, extracts on the oral glucose tolerance curve, on glycemia in alloxan-induced diabetic rats and vasorelaxant effect after the extraction process, and to standardize the extractive solutions. The effects of the process variables and their interactions were calculated in relation to dry residue, pH, total phenolic results and chemical marker content. Furthermore, the effect of the extracts (400 mg/kg, chlorogenic (2 or 15 mg/kg and caffeic acids (2 mg/kg were investigated on the oral glucose tolerance curve and on glycemia in alloxan-induced diabetic rats. Oral administration of ethanol extracts 4d20 and 8d20 significantly improved glucose tolerance in the hyperglycemic rats. Chlorogenic and caffeic acids, as well as the association of the compounds were able to significantly reduce glycemia after oral gavage treatments. On the other hand, the aqueous extracts did not alter the glycemia. The aqueous extracts (8020 and 9030 and only the higher dose of chlorogenic acid presented a significant effect on serum glucose lowering in diabetic rats. Additionally, the IC50 reveals that the ethanol extracts presented more potent vasodilator effects than the aqueous extracts in aortic rings. This study shows that C. glazioviistandardized extracts exhibits antihyperglycemic action, is able to improve glucose tolerance and has a potent vascular relaxing effect. These results are probably linked to concentrations of the main phenolic compounds of the extracts.

  15. Screening for antibiofilm and antioxidant potential of turmeric (Curcuma longa) extracts.

    Science.gov (United States)

    Hayat, Sumreen; Sabri, Anjum Nasim

    2016-07-01

    The antibiofilm and antioxidant activities associated with turmeric were the main focus of the study. Antibacterial activity was explored against bacteria isolated from dental plaques and dental unit water lines exhibiting resistance against antibiotics and biocides respectively. This study provides a comparison of the natural plant extract against synthetic mouthwash, chemicals and commonly prescribed antibiotics. Methanol extract was more effective as compared to other extracts. Minimum inhibitory concentrations (MIC) ranged from 2.5-10mg/ml. Time based killing kinetic assay showed a significant reduction of bacterial load with increasing concentration of turmeric. Micro titer plate assay indicated significant inhibition of biofilm formation in cells treated with turmeric extract. Phytochemical screening of plant extracts showed the presence of vital secondary metabolites. Flavonoid content and total phenolic content varied among extracts, phenolic content for methanolic extract was 61.669 mg GAE/ gm dry extract and flavonoid content was 3.119mg quercitin/gm dry extract. The values of ferric reducing power were in the range of 5.55- 15.55 mmol of FeSO4 equivalent/ liter of the extract. Antioxidant activities and total phenolic content of the turmeric extracts had significant positive correlation. On the basis of these results turmeric may confidently be recommended as natural antibiofilm and antioxidant agent.

  16. 2009 Ground Robotics Capabilities Conference and Exhibition

    Science.gov (United States)

    2009-03-26

    Deployments on the rise; lack of manpower to support home- station mission • Need a force multiplier... a semi-autonomous robot to augment our...manner. Extremis Casualty Extraction Extremis Casualty Evacuation -Identified as too slow to execute. - Reality of robot being in proper place to evacuate... Haptics , LLC Nomadio, Inc. Concurremt EDA Kuchera Def. Sys. Three Rivers 3D Maryland AnthroTronix, Inc. General Dynamics Robotic Syst Lockheed Martin

  17. Tooth extraction

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/007630.htm Tooth extraction To use the sharing features on this page, please enable JavaScript. A tooth extraction is a procedure to remove a tooth from ...

  18. Antimutagenicity of an acetone extract of yogurt.

    Science.gov (United States)

    Nadathur, S R; Gould, S J; Bakalinsky, A T

    1995-04-01

    Reconstituted non-fat dry milk powder, fermented by a mixture of Streptococcus thermophilus CH3 and Lactobacillus bulgaricus 191R to produce yogurt, was freeze-dried and extracted in acetone. After evaporation of the acetone, the extract was dissolved in dimethyl sulfoxide (DMSO) and tested for antimutagenicity. In the Ames test, significant dose-dependent activity was observed against N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 4-nitro-quinoline-N-oxide (4NQO), 3,2'-dimethyl-4-aminobiphenyl (DMAB), 9,10-dimethyl-1,2-benz[a]anthracene (DMBA), and 3-amino-1-methyl-5H-pyrido[4,3-b]indole acetate (Trp-P-2). Weak activity was observed against 1,2,7,8-diepoxyoctane (DEO), and no activity was observed against methyl methanesulfonate (MMS), ethyl methanesulfonate (EMS), or aflatoxin B1 (AFB1). In a related assay (Saccharomyces cerevisiae D7), significant antimutagenic activity was detected against MNNG and 4NQO. Activity against the experimental colon carcinogens MNNG and DMAB was examined further, as assayed in the Ames test (Salmonella typhimurium TA100). Compounds responsible for both activities were less soluble in aqueous solutions than in DMSO. Adjustment of yogurt pH to 3, 7.6, or 13 prior to freeze-drying and acetone extraction did not significantly alter the amount of anti-MNNG activity recovered. In contrast, extractability of anti-DMAB activity was significantly greater at acidic pH. Conjugated linoleic acid, a known dairy anticarcinogen, failed to inhibit mutagenesis caused by either mutagen, suggesting that other yogurt-derived compound(s) are responsible. Unfermented milk was treated with lactic acid, yogurt bacteria without subsequent growth, or both, to determine if formation of antimutagenic activity required bacterial growth. Extracts of the milk treatments exhibited the same weak antimutagenicity observed in unfermented milk, approximately 2.5-fold less than in the yogurt extracts, suggesting that antimutagenic activity is associated with bacterial

  19. Antimicrobial activity of Antrodia camphorata extracts against oral bacteria.

    Science.gov (United States)

    Lien, Hsiu-Man; Tseng, Chin-Jui; Huang, Chao-Lu; Lin, Yu-Ting; Chen, Chia-Chang; Lai, Ya-Yun

    2014-01-01

    Antrodia camphorata (A. camphorata) is a unique, endemic and extremely rare mushroom species native to Taiwan, and both crude extracts of and purified chemical compounds from A. camphorata have been reported to have a variety of significant beneficial effects, such as anti-tumor and anti-inflammatory activity. However, reports on the effects of A. camphorata against dental pathogens have been limited. Oral health is now recognized as important for overall general health, including conditions such as dental caries, periodontal disease and rheumatoid arthritis. Streptococcus mutans (S. mutans) and Porphyromonas gingivalis (P. gingivalis) are the most common bacteria associated with dental plaque and periodontopathic diseases, respectively. Thus, our study examined the ability of five various crude extracts of A. camphorata to inhibit the growth of dental bacteria and anti-adherence in vitro. Among the extracts, the ethanol, ethyl acetate and chloroform extracts exhibited the lowest MICs against P. gingivalis and S. mutans (MIC = 4∼16 µg/mL). The MIC of the aqueous extract was greater than 2048 µg/mL against both P. gingivalis and S. mutans. In vitro adherence of S. mutans was significantly inhibited by the addition of either the ethyl acetate extract or chloroform extract (MIC = 16∼24 µg/mL), while the ethanol extract (MIC = 32∼64 µg/mL) exhibited moderate inhibitory activity. Based on the result of this study, the ethyl acetate and chloroform extracts of A. camphorata may be good candidates for oral hygiene agents to control dental caries and periodontopathic conditions.

  20. Antimicrobial activity of Antrodia camphorata extracts against oral bacteria.

    Directory of Open Access Journals (Sweden)

    Hsiu-Man Lien

    Full Text Available Antrodia camphorata (A. camphorata is a unique, endemic and extremely rare mushroom species native to Taiwan, and both crude extracts of and purified chemical compounds from A. camphorata have been reported to have a variety of significant beneficial effects, such as anti-tumor and anti-inflammatory activity. However, reports on the effects of A. camphorata against dental pathogens have been limited. Oral health is now recognized as important for overall general health, including conditions such as dental caries, periodontal disease and rheumatoid arthritis. Streptococcus mutans (S. mutans and Porphyromonas gingivalis (P. gingivalis are the most common bacteria associated with dental plaque and periodontopathic diseases, respectively. Thus, our study examined the ability of five various crude extracts of A. camphorata to inhibit the growth of dental bacteria and anti-adherence in vitro. Among the extracts, the ethanol, ethyl acetate and chloroform extracts exhibited the lowest MICs against P. gingivalis and S. mutans (MIC = 4∼16 µg/mL. The MIC of the aqueous extract was greater than 2048 µg/mL against both P. gingivalis and S. mutans. In vitro adherence of S. mutans was significantly inhibited by the addition of either the ethyl acetate extract or chloroform extract (MIC = 16∼24 µg/mL, while the ethanol extract (MIC = 32∼64 µg/mL exhibited moderate inhibitory activity. Based on the result of this study, the ethyl acetate and chloroform extracts of A. camphorata may be good candidates for oral hygiene agents to control dental caries and periodontopathic conditions.

  1. Optimization of extraction conditions of total phenolics, antioxidant activities, and anthocyanin of oregano, thyme, terebinth, and pomegranate.

    Science.gov (United States)

    Rababah, Taha M; Banat, Fawzi; Rababah, Anfal; Ereifej, Khalil; Yang, Wade

    2010-09-01

    The purpose of this study was to evaluate the total phenolic extracts and antioxidant activity and anthocyanins of varieties of the investigated plants. These plants include oregano, thyme, terebinth, and pomegranate. The optimum extraction conditions including temperature and solvent of the extraction process itself were investigated. Total phenolic and anthocyanin extracts were examined according to Folin-Ciocalteu assay and Rabino and Mancinelli method, respectively. The effect of different extracting solvents and temperatures on extracts of phenolic compounds and anthocyanins were studied. Plant samples were evaluated for their antioxidant chemical activity by 2, 2-diphenyl-1-picrylhydrazl assay, to determine their potential as a source of natural antioxidant. Results showed that all tested plants exhibited appreciable amounts of phenolic compounds. The methanolic extract (60 °C) of sour pomegranate peel contained the highest phenolic extract (4952.4 mg/100 g of dry weight). Terebinth green seed had the lowest phenolic extract (599.4 mg/100 g of dry weight). Anthocyanins ranged between 3.5 (terebinth red seed) and 0.2 mg/100 g of dry material (thyme). Significant effect of different extracting solvents and temperatures on total phenolics and anthocyanin extracts were found. The methanol and 60 °C of extraction conditions found to be the best for extracting phenolic compounds. The distilled water and 60 °C extraction conditions found to be the best for extracting anthocyanin.

  2. Hypolipidemic and antihyperlipidemic effects of Lagenaria siceraria (Mol.) fruit extracts.

    Science.gov (United States)

    Ghule, B V; Ghante, M H; Saoji, A N; Yeole, P G

    2006-11-01

    Bottle gourd [(Lagenaria siceraria (Mol.) Stand.] fruit is ascribed with many therapeutic effects. The present study was undertaken to explore the antihyperlipidemic effect of four different extracts viz. petroleum ether, chloroform, alcoholic and aqueous extracts from bottle gourd in Triton-induced hyperlipidemic rats and their hypolipidemic effects in normocholesteremic rats. The study is comprised preliminary phytochemical screening of the extracts. Oral administration of the extracts, at doses of 200 and 400 mg/kg body weight in rats, dose-dependently inhibited the total cholesterol, triglycerides, low-density lipoproteins level, and significantly increased the high density lipoproteins level. However, petroleum ether extract did not show the significant effects. Both the chloroform and alcoholic extract exhibited more significant effects in lowering total cholesterol, triglycerides and low density lipoproteins along with increase in HDL as compared to the others. Preliminary phytochemical screening revealed the presence of flavonoids, sterols, cucurbitacin saponins, polyphenolics, proteins, and carbohydrates. The results obtained suggest marked antihyperlipidemic and hypolipidemic activity of the extracts.

  3. The palaeontological exhibition: a venue for dialogue.

    Science.gov (United States)

    Murriello, Sandra

    2015-01-01

    Understanding the dialogue between museums and their visitors enables museums to subsist, undergo transformations and become consolidated as socially valued cultural venues. The Museo de La Plata (Argentina) was created in the late nineteenth century as a natural history museum, and this study shows that currently the museum is valued socially as a venue for family leisure and education, at which people make sense to the objects exhibited through characteristics conferred upon them by both the institution and the visitor. Nevertheless, such dialogue is somehow affected by the museographic proposal and the public interpretation of the institutional narrative, which could be analysed within the frame of contextual learning. As a consequence, the evolutionary idea that the museum aims to communicate is distorted by the public. This article highlights the importance of considering the visitors' interpretations when planning museum exhibitions, a perspective that has been rather absent in the Argentinian museums.

  4. Exhibition: Women and Sciences by Fiami

    CERN Multimedia

    Globe Info

    2011-01-01

    The 19-panel exhibition is on display at CERN's Microcosm from Monday to Saturday from 10.00 a.m. to 5.00 p.m.   Marie Curie won the Nobel Prize for Chemistry one hundred years ago. She is the only woman ever to win two Nobel Prizes, which is a testament to her remarkable work. But throughout history, women have played a role in science either in their own right or alongside other scientists. In this special exhibition, the comic-strip artist Fiami takes a look back at the relationship between women and science through his portraits of Mileva Einstein, Marie-Anne Lavoisier and, of course, Marie Curie. Fiami has recently published an entire album devoted to Marie Curie. Texts in French All ages - Entrance free Femmes et Sciences is on display at Microcosm: From Wednesday 21 September 2011 to Tuesday 20 December 2011.

  5. Active Cyber Defense Dynamics Exhibiting Rich Phenomena

    CERN Document Server

    Zheng, Ren; Xu, Shouhuai

    2016-01-01

    The Internet is a man-made complex system under constant attacks (e.g., Advanced Persistent Threats and malwares). It is therefore important to understand the phenomena that can be induced by the interaction between cyber attacks and cyber defenses. In this paper, we explore the rich phenomena that can be exhibited when the defender employs active defense to combat cyber attacks. To the best of our knowledge, this is the first study that shows that {\\em active cyber defense dynamics} (or more generally, {\\em cybersecurity dynamics}) can exhibit the bifurcation and chaos phenomena. This has profound implications for cyber security measurement and prediction: (i) it is infeasible (or even impossible) to accurately measure and predict cyber security under certain circumstances; (ii) the defender must manipulate the dynamics to avoid such {\\em unmanageable situations} in real-life defense operations.

  6. CERN's new microcosm exhibition is now open

    CERN Multimedia

    2016-01-01

    After a major revamp in 2015, CERN’s microcosm exhibition is once again open to visitors. The exhibition is free and open to all without reservation and visitors are encouraged to share their #microcosm @CERN experiences on social media. Read more: http://cern.ch/go/7HWC -Producer- CERN Video Productions -Director- Kate Kahle -Camera- indissoluble.com and Julien Ordan -Editor- Julien Ordan -Infography- Daniel Dominguez Noemi Caraban -Music- “Light Years” by Stellardrone http://freemusicarchive.org/music/Ste... You can follow us on: cern.ch youtube.com/cerntv google.com/+CERN facebook.com/cern twitter.com/cern/ linkedin.com/company/cern instagram.com/cern Copyright © 2016 CERN. Terms of use: http://copyright.web.cern.ch/

  7. Ikuo Hirayama Painting Exhibition Held in Beijing

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    <正>To celebrate the 30th anniversary of the signing of the Sino-Japanese Peace and Friendship Treaty, the Ikuo Hirayama Painting Exhibition jointly sponsored by the China-Japan Friendship Association (CJFA), the China International Culture Association (CICA) and the Japan-China Friendship Association (JCFA), was held in the National Art Museum of China from April 17 to 26. At the invitation of the CJFA, Tomiichi Murayama, former Japanese prime minister, and Ikuo Hirayama, president of the JCFA and famous painter, who led a delegation of over 200 people of various circles, paid a visit to China to attend the opening ceremony of the exhibition and take part in the relevant activities from April 16 to 20.

  8. LHC INAUGURATION, LHC Fest highlights: exhibition time!

    CERN Multimedia

    2008-01-01

    David Gross, one of the twenty-one Nobel Laureates who have participated in the project.Tuesday 21 October 2008 Accelerating Nobels Colliding Charm, Atomic Cuisine, The Good Anomaly, A Quark Somewhere on the White Paper, Wire Proliferation, A Tale of Two Liquids … these are just some of the titles given to artworks by Physics Nobel Laureates who agreed to make drawings of their prize-winning discoveries (more or less reluctantly) during a special photo session. Science photographer Volker Steger made portraits of Physics Nobel Laureates and before the photo sessions he asked them to make a drawing of their most important discovery. The result is "Accelerating Nobels", an exhibition that combines unusual portraits of and original drawings by twenty-one Nobel laureates in physics whose work is closely related to CERN and the LHC. This exhibition will be one of the highlights of the LHC celebrations on 21 October in the SM18 hall b...

  9. Pingyao Traditional Cultural Exhibition Mounted in France

    Institute of Scientific and Technical Information of China (English)

    Ni; Yuan

    2014-01-01

    <正>On the initiative of Provins,a commune in the Nord Department of Northern France and a friendship city of Pingyao in Shanxi Province,an exhibition of Pingyao traditional cultural and art works was staged from June 14 to 17.On display in the ancient SaintQuiriace Collegiate Church were 40 artworks characteristic of the traditional folk art of North China including old photos of Pingyao,calligraphic works,paintings,paper-cut,embroidery and shadow puppets.

  10. Cinema Film Distribution and Exhibition in Ireland

    OpenAIRE

    O'Donnell, Damien

    1992-01-01

    This study of cinema film distribution and exhibition practices In Ireland examines key aspects of the Industry: firstly, the basic mechanics of the Industry and Its operations: secondly, the various alignments between exhibitors and distributors and consequences of those alignments: thirdly, the impact of the arrival of British multiplex companies: fourthly, the costs of film censorship; and finally, the idea of an 'art-house' circuit In Ireland.

  11. PLATE: Product Lifetimes And The Environment Exhibition

    OpenAIRE

    Hanson, Maria

    2015-01-01

    The PLATE (Product Lifetimes And The Environment) Exhibition explored critical themes related to how long products last in contemporary society. The topic of product longevity is examined in innovative ways through prototypes, objects, artefacts, posters, photographs and films produced by designers, social businesses, artists, researchers, lecturers and students.\\ud \\ud Featuring household products, furniture, lighting, fashion, jewellery and artworks, this collection of visual work embraced ...

  12. Exhibition: Dialogue between Science and religion

    CERN Multimedia

    2001-01-01

    Can the theory of the Big Bang reached by physicists and the concept of creation beloved of religion ever be reconciled? The two approaches have at least one point in common: they do not provide a final answer to the mysteries of the birth of the Universe. And this means that dialogue is alays possible between the two. It is to show the potential of such an exchange that Geneva's Société Evangélique organization is opening an exhibition under the title 'Big Bang and Creation', at the Planète Charmilles shopping centre, to run from 19 to 30 March. View of the 'Big Bang and Creation' exhibition. The exhibition is divided into three sections, showing the views of the scientist and those of the believer without setting them up in opposition to one another. In the first section, under a representation of the vault of heaven, the visitor will discover the different ideas explaining the birth of the Universe: Genesis and the Big Bang, and the different dominant theories ...

  13. Synchronization in multicell systems exhibiting dynamic plasticity

    Indian Academy of Sciences (India)

    C Suguna; Somdatta Sinha

    2008-08-01

    Collective behaviour in multicell systems arises from exchange of chemicals/signals between cells and may be different from their intrinsic behaviour. These chemicals are products of regulated networks of biochemical pathways that underlie cellular functions, and can exhibit a variety of dynamics arising from the non-linearity of the reaction processes. We have addressed the emergent synchronization properties of a ring of cells, diffusively coupled by the end product of an intracellular model biochemical pathway exhibiting non-robust birhythmic behaviour. The aim is to examine the role of intercellular interaction in stabilizing the non-robust dynamics in the emergent collective behaviour in the ring of cells. We show that, irrespective of the inherent frequencies of individual cells, depending on the coupling strength, the collective behaviour does synchronize to only one type of oscillations above a threshold number of cells. Using two perturbation analyses, we also show that this emergent synchronized dynamical state is fairly robust under external perturbations. Thus, the inherent plasticity in the oscillatory phenotypes in these model cells may get suppressed to exhibit collective dynamics of a single type in a multicell system, but environmental influences can sometimes expose this underlying plasticity in its collective dynamics.

  14. Art exhibit focuses on African astronomy

    Science.gov (United States)

    Showstack, Randy

    2012-07-01

    Connections between Africans and astronomy are the focus of a new exhibition in the National Museum of African Art in Washington, D. C. "African Cosmos: Stellar Arts," which includes artwork, cultural items, and scientific displays from ancient to contemporary times, is the first major exhibit "that brings together arts and science focused on Africa's contribution to keen observations of the heavens over time," curator Christine Mullen Kreamer said at a 20 June news briefing. Among the exhibit's nearly 100 objects are an ancient Egyptian mummy board that includes a representation of the sky goddess Nut, sculptures by the Dogon people of Mali depicting figures in relation to the cosmos, a video that uses data from two square degrees of the Hubble Space Telescope Cosmic Evolution Survey, and a nearly floor-to-ceiling "Rainbow Serpent" constructed of plastic containers by Benin artist Hazoume. An untitled acrylic painting (Figure 1) by South African Gavin Jantjes evokes a myth of the Khoi San people of southern Africa, as it portrays a girl throwing evening fire embers into the night sky, where they remained as the Milky Way.

  15. Exhibition: Linus Pauling and the Twentieth Century

    CERN Document Server

    2003-01-01

    On April 28 the exhibit Linus Pauling and the Twentieth Century organised by UNIDIR (United Nations Institute for Disarmament Research) and SGI (Soka Gakkai International) as well as with the contributions of CERN and the University of Geneva, opened at the United Nations Office of Geneva. Linus Pauling is the only person to date to have won two unshared Nobel Prizes: Chemistry in 1954 and Peace in 1962. The first was awarded for his landmark research on the nature of the chemical bond and its application in understanding the structure of complex substances. The second one acknowledged his courageous protest against atmospheric nuclear testing and his championship of international peace. The exhibit, for audience of all ages, traces seven decades of Linus Pauling's life and influence on the 20th century. Before starting its European tour at the UNESCO headquarters in Paris, the exhibit opened in 1998 in San Francisco and then travelled within the United-States and to Japan with an attendance of more than one...

  16. Exhibition: Linus Pauling and the Twentieth Century

    CERN Multimedia

    2003-01-01

    On April 28 the exhibit Linus Pauling and the Twentieth Century organised by UNIDIR (United Nations Institute for Disarmament Research) and SGI (Soka Gakkai International) as well as with the contributions of CERN and the University of Geneva, opens at the United Nations Office of Geneva. Linus Pauling is the only person to date to have won two unshared Nobel Prizes: Chemistry in 1954 and Peace in 1962. The first was awarded for his landmark research on the nature of the chemical bond and its application in understanding the structure of complex substances. The second one acknowledged his courageous protest against atmospheric nuclear testing and his championship of international peace. The exhibit, for all ages' audiences, traces seven decades of Linus Pauling's life and influence on the 20th century. Before starting its European tour at the UNESCO headquarters in Paris, the exhibit opened in 1998 in San Francisco and then travelled within the United-States and to Japan with an attendance of more than one m...

  17. Antioxidant, Antinociceptive, and Anti-Inflammatory Effects of Carotenoids Extracted from Dried Pepper (Capsicum annuum L.)

    Science.gov (United States)

    Hernández-Ortega, Marcela; Ortiz-Moreno, Alicia; Hernández-Navarro, María Dolores; Chamorro-Cevallos, Germán; Dorantes-Alvarez, Lidia; Necoechea-Mondragón, Hugo

    2012-01-01

    Carotenoids extracted from dried peppers were evaluated for their antioxidant, analgesic, and anti-inflammatory activities. Peppers had a substantial carotenoid content: guajillo 3406 ± 4 μg/g, pasilla 2933 ± 1 μg/g, and ancho 1437 ± 6 μg/g of sample in dry weight basis. A complex mixture of carotenoids was discovered in each pepper extract. The TLC analysis revealed the presence of chlorophylls in the pigment extract from pasilla and ancho peppers. Guajillo pepper carotenoid extracts exhibited good antioxidant activity and had the best scavenging capacity for the DPPH+ cation (24.2%). They also exhibited significant peripheral analgesic activity at 5, 20, and 80 mg/kg and induced central analgesia at 80 mg/kg. The results suggest that the carotenoids in dried guajillo peppers have significant analgesic and anti-inflammatory benefits and could be useful for pain and inflammation relief. PMID:23091348

  18. Antioxidant, Antinociceptive, and Anti-Inflammatory Effects of Carotenoids Extracted from Dried Pepper (Capsicum annuum L.

    Directory of Open Access Journals (Sweden)

    Marcela Hernández-Ortega

    2012-01-01

    Full Text Available Carotenoids extracted from dried peppers were evaluated for their antioxidant, analgesic, and anti-inflammatory activities. Peppers had a substantial carotenoid content: guajillo 3406±4 μg/g, pasilla 2933±1 μg/g, and ancho 1437±6 μg/g of sample in dry weight basis. A complex mixture of carotenoids was discovered in each pepper extract. The TLC analysis revealed the presence of chlorophylls in the pigment extract from pasilla and ancho peppers. Guajillo pepper carotenoid extracts exhibited good antioxidant activity and had the best scavenging capacity for the DPPH+ cation (24.2%. They also exhibited significant peripheral analgesic activity at 5, 20, and 80 mg/kg and induced central analgesia at 80 mg/kg. The results suggest that the carotenoids in dried guajillo peppers have significant analgesic and anti-inflammatory benefits and could be useful for pain and inflammation relief.

  19. Antioxidant, antinociceptive, and anti-inflammatory effects of carotenoids extracted from dried pepper (Capsicum annuum L.).

    Science.gov (United States)

    Hernández-Ortega, Marcela; Ortiz-Moreno, Alicia; Hernández-Navarro, María Dolores; Chamorro-Cevallos, Germán; Dorantes-Alvarez, Lidia; Necoechea-Mondragón, Hugo

    2012-01-01

    Carotenoids extracted from dried peppers were evaluated for their antioxidant, analgesic, and anti-inflammatory activities. Peppers had a substantial carotenoid content: guajillo 3406 ± 4 μg/g, pasilla 2933 ± 1 μg/g, and ancho 1437 ± 6 μg/g of sample in dry weight basis. A complex mixture of carotenoids was discovered in each pepper extract. The TLC analysis revealed the presence of chlorophylls in the pigment extract from pasilla and ancho peppers. Guajillo pepper carotenoid extracts exhibited good antioxidant activity and had the best scavenging capacity for the DPPH(+) cation (24.2%). They also exhibited significant peripheral analgesic activity at 5, 20, and 80 mg/kg and induced central analgesia at 80 mg/kg. The results suggest that the carotenoids in dried guajillo peppers have significant analgesic and anti-inflammatory benefits and could be useful for pain and inflammation relief.

  20. Complementary and comparative study on hypoglycemic and antihyperglycemic activity of various extracts of Eugenia jambolana seed, Momordica charantia fruits, Gymnema sylvestre, and Trigonella foenum graecum seeds in rats.

    Science.gov (United States)

    Yadav, Mukesh; Lavania, Amita; Tomar, Radha; Prasad, G B K S; Jain, Shalini; Yadav, Hariom

    2010-04-01

    In present study, we investigated hypoglycemic and antihyperglycemic potential of five extracts (water, ethanol, methanol, hexane, and chloroform) of four plants (i.e., seeds of Eugenia jambolana, fruits of Momordica charantia, leaves of Gymnema sylvestre, and seeds of Trigonella foenum graecum) alone and/or in combination with glimepiride in rats. Ethanol extract of E. jambolana, water extract of M. charantia, ethanol extract of G. sylvestre, and water extract of T. graecum exhibited highest hypoglycemic and antihyperglycemic activity (most active) in rats among all the extracts, while hexane extracts exhibited least activities. Most active extracts were further studied to dose-dependent (200, 100, and 50 mg/kg body weight (bw)) hypoglycemic and antihyperglycemic effects alone and in combination with glimepiride (20, 10, and 5 mg/kg bw). The combination of most active extracts (200 mg/kg bw) and lower dose of glimepiride (5 mg/kg bw) showed safer and potent hypoglycemic as well as antihyperglycemic activities without creating severe hypoglycemia in normal rats, while higher doses (200 mg/kg bw of most active extracts, and 10 and 20 mg/kg bw of glimepiride) were generated lethal hypoglycemia in normal rats. From this study, it may be concluded that the ethanol extract of E. jambolana seeds, water extract of M. charantia fruits, ethanol extract of G. sylvestre leaves, and water extract of T. graecum seeds have higher hypoglycemic and antihyperglycemic potential and may use as complementary medicine to treat the diabetic population by significantly reducing dose of standard drugs.

  1. Antiinflammatory, antinociceptive and antioxidant activities of Phyllanthus acidus L. extracts

    Institute of Scientific and Technical Information of China (English)

    Raja Chakraborty; Biplab De; Nayakanti Devanna; Saikat Sen

    2012-01-01

    Objective: To evaluate analgesic, anti-inflammatory and in vitro antioxidant potential and determine total phenolic, total flavonoid content of leaves extracts of Phyllanthus acidus, a folk medicinal plant of India. Methods: Anti-inflammatory activity was evaluated using carrageenan induced paw oedema, cotton pellet induced granuloma, membrane stabilizing activity method. Analgesic activity of the extracts was estimated against acetic acid induced writhing, tail immersion method, formalin test. Free radical scavenging and antioxidant potential of the extracts of Phyllanthus acidus leaves was performed using several in vitro and ex vivo assay models. Total phenolic and total flavonoid contents of the extracts were determined using standard chemical methods. Results: The extracts exhibited significant anti-inflammatory and analgesic activities at dose dependent manner. Methanol extract at a dose of 500 mg/kg showed superior activity which was comparable with the standard drugs. Ethyl acetate extract showed moderate activity while petroleum ether extract showed least activity. Total phenolic and total flavonoid content in methanol extract were 73.08±0.682 mg GAE/g and 61.28±0.062 mg QE/g respectively. The extracts possess significant antioxidant activity, methanol extract showed highest IC50 value. The contents of flavonoids and phenolic compounds could be correlated with the antioxidant, analgesic and anti-inflammatory activities observed for Phyllanthus acidus leaves. Conclusion:Our findings suggest that Phyllanthus acidus contains potential antioxidant, analgesic and anti-inflammatory compounds which could be tested as drug candidates against oxidative stress, pain and inflammation related pathological diseases.

  2. Formulation of a fish feed for goldfish with natural astaxanthin extracted from shrimp waste

    OpenAIRE

    Weeratunge, W. K. O. V.; Perera, B. G. K.

    2016-01-01

    Background Astaxanthin is a xanthophyll carotenoid, which exhibits many important biological activities including a high degree of antioxidant capacity (AOC) and antibacterial activity, hence has a significant applicability in food, pharmaceutical and cosmetic industries. An attempt was made towards optimization of astaxanthin extraction conditions using three different extraction conditions and a solvent series, from uncooked, cooked and acid-treated shrimp waste, which is a readily availabl...

  3. Protective effect of root extract of Operculina turpethum linn. Against paracetamol-induced hepatotoxicity in rats

    Directory of Open Access Journals (Sweden)

    Suresh Kumar S

    2006-01-01

    Full Text Available The ethanolic extract obtained from roots of Operculina turpethum (Convolvulaceae were evaluated for hepatoprotective activity in rats by inducing liver damage by paracetamol. The ethanol extract at an oral dose of 200 mg/kg exhibited a significant protective effect by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase and total bilirubin. These biochemical observations were supplemented by histopathological examination of liver sections. Silymarin was used as positive control.

  4. Mars in their eyes - a cartoon exhibition

    Science.gov (United States)

    Pillinger, Pi.

    Recently a collection of 120 cartoons which tell the story of Mars exploration and scientific discovery, past, present and future, was held in London. We discuss the aims of the exhibition, to what extent we believe the original aims were met and report on additional outreach opportunities resulting from the project. The overriding aim was to capitalise on the popular appeal of accessible art - most people admit to enjoying cartoons. This was strengthened by hanging the originals of cartoons which had, mostly, been published in newspapers and magazines in a wide selection of countries. The provenances served to indicate the attraction of Mars to a wide public. We were fortunate to work with the Cartoon Art Trust of the UK who was in the process of relocating to new premises and opening as The Cartoon Museum, in the tourist area of Bloomsbury, central London, very close to the British Museum. "Mars in their Eyes" ran for 10 weeks during April to July 2006; immediately following which a selection of the cartoons was displayed at the week-long Royal Society Summer Exhibition. We explore the differences between the two exhibitions and comment on the various audience responses. We use this comparison to discuss whether a project which is primarily art can be extended to explain science. Does the coupling merely result in dumbing-down of both cultures or is there a true synergy? The experience has led us to coin the phrase "extreme outreach". Projects which are as ambitious as "Mars in their Eyes", without the security of a safe, captive audience, for example at a Science Centre, must be judged by different criteria. Indeed if the project does not meet comparable targets like large visitor numbers, then the honest evaluation of such details can only inform future activities and must not be reflected in the future funding of only "safe" outreach activities.

  5. Characterization of Catalase from Psychrotolerant Psychrobacter piscatorii T-3 Exhibiting High Catalase Activity

    OpenAIRE

    Hidetoshi Matsuyma; Isao Yumoto; Hideyuki Kimoto; Kazuaki Yoshimune

    2012-01-01

    A psychrotolerant bacterium, strain T-3 (identified as Psychrobacter piscatorii), that exhibited an extraordinarily high catalase activity was isolated from the drain pool of a plant that uses H2O2 as a bleaching agent. Its cell extract exhibited a catalase activity (19,700 U·mg protein−1) that was higher than that of Micrococcus luteus used for industrial catalase production. Catalase was approximately 10% of the total proteins in the cell extract of the strain. The catalase (PktA) was purif...

  6. Art Therapy Exhibitions: Exploitation or Advocacy?

    Science.gov (United States)

    Davis, Terri

    2017-01-01

    Promoting awareness of human trafficking by sharing trauma survivors' art and summaries of their life stories suggests ethical complexities that have been typically neglected by bioethicists. Although these survivors voluntarily share the objects they created during art therapy sessions, they are still at risk of harm, including further exploitation, due to their vulnerability, high rates of victim sensitivity, and the mental health consequences of their traumatic experiences. While some argue that the benefits of sublimation and art therapy for human trafficking survivors make sharing their art worth the risk, anti-trafficking organizations and supporters of such art exhibitions have responsibilities to be trauma informed. © 2017 American Medical Association. All Rights Reserved.

  7. Library exhibits and programs boost science education

    Science.gov (United States)

    Dusenbery, Paul B.; Curtis, Lisa

    2012-05-01

    Science museums let visitors explore and discover, but for many families there are barriers—such as cost or distance—that prevent them from visiting museums and experiencing hands-on science, technology, engineering, and mathematics (STEM) learning. Now educators are reaching underserved audiences by developing STEM exhibits and programs for public libraries. With more than 16,000 outlets in the United States, public libraries serve almost every community in the country. Nationwide, they receive about 1.5 billion visits per year, and they offer their services for free.

  8. Antimalarial Activity of Methanolic Leaf Extract of Piper betle L.

    Directory of Open Access Journals (Sweden)

    Adel A. Amran

    2010-12-01

    Full Text Available The need for new compounds active against malaria parasites is made more urgent by the rapid spread of drug-resistance to available antimalarial drugs. The crude methanol extract of Piper betle leaves (50–400 mg/kg was investigated for its antimalarial activity against Plasmodium berghei (NK65 during early and established infections. The phytochemical and antioxidant potentials of the crude extract were evaluated to elucidate the possibilities of its antimalarial effects. The safety of the extract was also investigated in ICR mice of both sexes by the acute oral toxicity limit test. The leaf extract demonstrated significant (P < 0.05 schizonticidal activity in all three antimalarial evaluation models. Phytochemical screening showed that the leaf extract contains some vital antiplasmodial chemical constituents. The extract also exhibited a potent ability to scavenge the free radicals. The results of acute toxicity showed that the methanol extract of Piper betle leaves is toxicologically safe by oral administration. The results suggest that the Malaysian folklorical medicinal application of the extract of Piper betle leaf has a pharmacological basis.

  9. Evaluation of the estrogenic effects of legume extracts containing phytoestrogens.

    Science.gov (United States)

    Boué, Stephen M; Wiese, Thomas E; Nehls, Suzanne; Burow, Matthew E; Elliott, Steven; Carter-Wientjes, Carol H; Shih, Betty Y; McLachlan, John A; Cleveland, Thomas E

    2003-04-09

    Seven legume extracts containing phytoestrogens were analyzed for estrogenic activity. Methanol extracts were prepared from soybean (Glycine max L.), green bean (Phaseolus vulgaris L.), alfalfa sprout (Medicago sativa L.), mung bean sprout (Vigna radiata L.), kudzu root (Pueraria lobata L.), and red clover blossom and red clover sprout (Trifolium pratense L.). Extracts of kudzu root and red clover blossom showed significant competitive binding to estrogen receptor beta (ERbeta). Estrogenic activity was determined using an estrogen-dependent MCF-7 breast cancer cell proliferation assay. Kudzu root, red clover blossom and sprout, mung bean sprout, and alfalfa sprout extracts displayed increased cell proliferation above levels observed with estradiol. The pure estrogen antagonist, ICI 182,780, suppressed cell proliferation induced by the extracts, suggesting an ER-related signaling pathway was involved. The ER subtype-selective activities of legume extracts were examined using transiently transfected human embryonic kidney (HEK 293) cells. All seven of the extracts exhibited preferential agonist activity toward ERbeta. Using HPLC to collect fractions and MCF-7 cell proliferation, the active components in kudzu root extract were determined to be the isoflavones puerarin, daidzin, genistin, daidzein, and genistein. These results show that several legumes are a source of phytoestrogens with high levels of estrogenic activity.

  10. Evaluation of antioxidant activity of medicinal plants containing polyphenol compounds. Comparison of two extraction systems.

    Science.gov (United States)

    Kratchanova, Maria; Denev, Petko; Ciz, Milan; Lojek, Antonin; Mihailov, Atanas

    2010-01-01

    This study investigates the influence of extraction system on the extractability of polyphenol compounds and antioxidant activity of various medicinal plants. Oxygen radical absorbance capacity (ORAC) and total polyphenol content of 25 Bulgarian medicinal plants subjected to water or 80 % acetone extractions were investigated and compared. The type of extragent significantly influenced the efficiency of the polyphenol extraction and the antioxidant activity. In all cases ORAC results and total polyphenol content were higher for acetone extraction than for water extraction. The acetone extract of peppermint had the highest ORAC value - 2917 micromol Trolox equivalent (TE)/g dry weight (DW) and polyphenol content - 20216 mg/100 g DW. For water extraction thyme exhibited the highest ORAC antioxidant activity - 1434 micromol TE/g DW. There was a significant linear correlation between the concentration of total polyphenols and ORAC in the investigated medicinal plants. It can be concluded that the solvent used affects significantly the polyphenol content and the antioxidant activity of the extract and therefore it is recommended to use more than one extraction system for better assessment of the antioxidant activity of natural products. Several of the investigated herbs contain substantial amounts of free radical scavengers and can serve as a potential source of natural antioxidants for medicinal and commercial uses.

  11. New Media Display Technology and Exhibition Experience

    Directory of Open Access Journals (Sweden)

    Chen-Wo Kuo

    2016-01-01

    Full Text Available As the inheritor of Chinese civilization, the National Palace Museum (hereafter referred to as the NPM, houses a world-class collection of cultural art and artifacts. Since the NPM began promoting the National Digital Archives Project in 2002, its efforts have expanded to develop a digital museum and various e-learning programs. Extending the use of digital archives to its educational and cultural industrial endeavors, the NPM has maximized the value of its exhibitions, publications, and educational programs.  In 2013, the NPM integrated creative thinking and interdisciplinary technologies, such as floating projection, augmented reality, and other sensory interactive media, to recreate the historical circumstance of 19th century East Asian maritime cultures in “Rebuilding the Tong-an Ships—New Media Art Exhibition," which opened at Huashan 1914 Creative Park and later won the Gold Award at the 2014 Digital Education Innovation Competition. Through a thorough exploration of the factors contributing to the success of "Rebuilding the Tong-an Ships," this study has isolated the two main factors of the exhibition’s popularity, namely, the compactness of the metadata and the atmosphere created by the interactive display technology.

  12. Children's drawings exhibited in the Globe

    CERN Multimedia

    Elizabeth Roe

    2010-01-01

    "Draw Me A Physicist" has been a success. Members of the public visiting the exhibition in the Globe of Science and Innovation have praised the scientific and creative balance the children of neighbouring France and the Canton of Geneva have obtained through their visit to CERN.   The Draw Me a Physicist exhibition in the Globe For a six-month period 9 to 11-year olds from the Pays de Gex, Meyrin, Satigny and Vernier have been able to enjoy a balance between science and art, through drawing and defining their interpretations of a physicist. In May, eight pairs of drawings from each participating class were selected by the schools to be displayed on the second floor of the Globe. Since the images have been put up, the viewers have enjoyed the contrast between the "before" pictures of vibrant Albert Einsteins to the "after" pictures of casual people sitting in an office. The large room in the Globe has been transformed from a hollow shell int...

  13. CERN Inspires Art in Major New Exhibition

    CERN Multimedia

    2001-01-01

    Signatures of the Invisible, an exhibition inspired by CERN, opened at the Atlantis Gallery in London on Thursday, 1 March before going on a world tour. The fruit of a close collaboration between CERN and the London Institute, the exhibition brings together works from many leading European contemporary artists. White wooden boxes on a grey floor... the lids opened, unveiling brilliant white light from a bunch of optical fibres carefully stuck together in the shape of a square. Another holds a treasure of lead glass surrounded by enigmatic black mirrors. What's it all about? Signatures of the Invisible, that's what, a joint project organised by the London Institute, one of the world's largest college of art, and our Laboratory. Damien Foresy from the EST workshop putting finishing touches to the spinning tops of French artist Jérôme Basserode. Monica Sand's boxes are just one of the many works based around materials used in particle detection at CERN that was admired at the opening o...

  14. Comparison of the outcomes of the lower incisor extraction, premolar extraction and non-extraction treatments.

    Science.gov (United States)

    Ileri, Zehra; Basciftci, Faruk Ayhan; Malkoc, Siddik; Ramoglu, Sabri Ilhan

    2012-12-01

    The aim of this retrospective study was to evaluate the treatment outcome of lower incisor extraction and to compare it with premolar extraction and non-extraction treatment. The sample consisted of 60 subjects with Class I malocclusion and moderate crowding. The sample was separated into three groups: extraction of a lower incisor group, extraction of a four first premolar group and a non-extraction group. All groups involved 13 girls and 7 boys with a total of 20 patients. The Peer assessment rating (PAR) index was applied to a patient's pre-treatment (T1) and post-treatment (T2) dental casts. T1 dental casts were also used for determining Bolton discrepancy. One-way analysis of variance and post hoc Tukey HSD tests were used for statistical analysis. For the mean percentage PAR score reduction for each group, there was one significant difference seen between the lower incisor extraction group and the non-extraction group (P = 0.047). For the mean anterior ratios, there were significant differences among premolar extraction group versus non-extraction group (P = 0.042) and non-extraction group versus lower incisor extraction group (P = 0.000). For the mean overall ratios, there were significant differences among the premolar extraction group versus lower incisor extraction group (P = 0.048) and the non-extraction group versus lower incisor extraction group (P = 0.001). Orthodontic treatment without extraction has a better treatment outcome than the four-first premolar extraction and single lower incisor extraction protocols in Class I cases with moderate to severe mandibular anterior crowding.

  15. A comparison of an optimised sequential extraction procedure and dilute acid leaching of elements in anoxic sediments, including the effects of oxidation on sediment metal partitioning.

    Science.gov (United States)

    Larner, Bronwyn L; Palmer, Anne S; Seen, Andrew J; Townsend, Ashley T

    2008-02-11

    The effect of oxidation of anoxic sediment upon the extraction of 13 elements (Cd, Sn, Sb, Pb, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As) using the optimised Community Bureau of Reference of the European Commission (BCR) sequential extraction procedure and a dilute acid partial extraction procedure (4h, 1 molL(-1) HCl) was investigated. Elements commonly associated with the sulfidic phase, Cd, Cu, Pb, Zn and Fe exhibited the most significant changes under the BCR sequential extraction procedure. Cd, Cu, Zn, and to a lesser extent Pb, were redistributed into the weak acid extractable fraction upon oxidation of the anoxic sediment and Fe was redistributed into the reducible fraction as expected, but an increase was also observed in the residual Fe. For the HCl partial extraction, sediments with moderate acid volatile sulfide (AVS) levels (1-100 micromolg(-1)) showed no significant difference in element partitioning following oxidation, whilst sediments containing high AVS levels (>100 micromolg(-1)) were significantly different with elevated concentrations of Cu and Sn noted in the partial extract following oxidation of the sediment. Comparison of the labile metals released using the BCR sequential extraction procedure (SigmaSteps 1-3) to labile metals extracted using the dilute HCl partial extraction showed that no method was consistently more aggressive than the other, with the HCl partial extraction extracting more Sn and Sb from the anoxic sediment than the BCR procedure, whilst the BCR procedure extracted more Cr, Co, Cu and As than the HCl extraction.

  16. Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats.

    Science.gov (United States)

    Kang, Myung-Hwa; Lee, Min Sun; Choi, Mi-Kyeong; Min, Kwan-Sik; Shibamoto, Takayuki

    2012-03-14

    Diabetes mellitus, which is associated with oxidative damage, has a significant impact on health, quality of life, and life expectancy. An ethanol extract of Gymnema sylvestre leaf was examined in vitro and in vivo to investigate the role of antioxidants in diabetic rats. The extract exhibited strong antioxidant activity in the assays, including TBA (56%), SOD-like (92%), and ABTS (54%). Blood glucose levels in the diabetic rats fed G. sylvestre extract decreased to normal levels. The presence of the antihyperglycemic compounds gymnemagenin and gymnemic acids in G. sylvestre extract was detected by LC/MS analysis. Lipid peroxidation levels were decreased by 31.7% in serum, 9.9% in liver, and 9.1% in kidney in the diabetic rats fed the extract. Feeding G. sylvestre extract to the diabetic rats decreased the activity of glutathione peroxidase in cytosolic liver and glutamate pyruvate transaminase in serum to normal levels.

  17. Extraction and Characterization of Antioxidant Compositions From Fermented Fruit Juice of Morinda citrifolia(Noni)

    Institute of Scientific and Technical Information of China (English)

    LIU Chang-hong; XUE Ya-rong; YE Yong-hang; YUAN Feng-feng; LIU Jun-yan; SHUANG Jing-lei

    2007-01-01

    Extraction and characterization of antioxidative compositions from the extracts of fermented Xisha Noni(Morinda citrifolia L.)juice were studied.The antioxidative constituents of 184.6g freeze-dried extracts of naturally fermented Xisha Noni juice were isolated successfully by petroleum ether,EtOAc and n-BuOH solvents,and the antioxidative effects were measured according to scavenging activity against hydroxyl generated in Fenton reaction system and superoxide anion radicals in pyrogallol autoxidation system.The EtOAc extract exhibited most significantly higher(P<0.01)antioxidative activity than mannitol or vitamin C,while the petroleum ether and n-BuOH extracts showed lower activities compared to were isolated from the EtOAc extract by several chromatography techniques for the first time.The results suggest that several compounds,in particular,the phenolic compounds,contribute separately or synergistically to the antioxidative activity of fermented Noni fruit juice.

  18. Exhibition Season: Annual Archaeological Exhibitions in London, 1880s-1930s

    Directory of Open Access Journals (Sweden)

    Amara Thornton

    2015-03-01

    Full Text Available Annual archaeological exhibitions were a visible symbol of archaeological research. Held mainly in London, the displays encapsulated a network of archaeologists, artists, architects and curators, and showcased the work of the first generations of trained archaeologists. The exhibition catalogues and published reviews of the displays provide a unique method for exploring the reception and sponsorship of archaeological work overseas and its promotion to a fascinated, well connected and well moneyed public. The exhibitions were a space in which conversation and networking were as important as educational enrichment. This paper analyses the social history of the “annual exhibition” in archaeology, highlighting the development and maintenance of the networks behind archaeological research, the geography of London as a way to examine influence in archaeology, and the utility of exhibitions for archaeological publicity during this period of exploration.

  19. Virtual auditorium concepts for exhibition halls

    Science.gov (United States)

    Evans, Jack; Himmel, Chad; Knight, Sarah

    2002-11-01

    Many communities lack good performance facilities for symphonic music, opera, dramatic and musical arts, but have basic convention, exhibition or assembly spaces. It should be possible to develop performance space environments within large multipurpose facilities that will accommodate production and presentation of dramatic arts. Concepts for moderate-cost, temporary enhancements that transform boxy spaces into more intimate, acoustically articulated venues will be presented. Acoustical criteria and design parameters will be discussed in the context of creating a virtual auditorium within the building envelope. Physical, economic, and logistical limitations affect implementation. Sound reinforcement system augmentation can supplement the room conversion. Acceptable control of reflection patterns, reverberation, and to some extent, ambient noise, may be achieved with an array of nonpermanent reflector and absorber elements. These elements can sculpture an enclosure to approach the shape and acoustic characteristics of an auditorium. Plan and section illustrations will be included.

  20. Exhibiting health and medicine as culture

    DEFF Research Database (Denmark)

    Bencard, Adam; Tybjerg, Karin; Whiteley, Louise;

    2017-01-01

    This paper discusses the potential role of medical museums in public engagement with health and medicine, based in the work of Medical Museion at the University of Copenhagen. Rather than asking if cultural venues such as museums can directly improve the wellbeing of their visitors, we instead...... focus on how museums should communicate about health and medicine. There is increasing emphasis on the need for health communication to recognize peoples’ multiple, lived cultures. We argue that we should also recognize that medical research and practice is itself a form of culture......, and as such is multiple and historically shifting. We suggest that museums are an ideal site for doing so, and can thereby contribute to public engagement with medicine that acknowledges multiplicity on both sides. The paper describes three examples of exhibitions at Medical Museion that attempt to display medicine...

  1. Ketogenic diet exhibits anti-inflammatory properties.

    Science.gov (United States)

    Dupuis, Nina; Curatolo, Niccolo; Benoist, Jean-François; Auvin, Stéphane

    2015-07-01

    The ketogenic diet (KD) is an established treatment for refractory epilepsy, including some inflammation-induced epileptic encephalopathies. In a lipopolysaccharide (LPS)-induced fever model in rats, we found that animals given the KD for 14 days showed less fever and lower proinflammatory cytokine levels than control animals. However, KD rats exhibited a decrease in circulating levels of arachidonic acid and long-chain n-3 polyunsaturated fatty acids (PUFAs), suggesting that the anti-inflammatory effect of KD was probably not due to an increase in anti-inflammatory n-3 PUFA derivatives. These properties might be of interest in some conditions such as fever-induced refractory epileptic encephalopathy in school-aged children.

  2. Antihyperglycemic, antioxidant and hypolipidemic effect of Punica granatum L flower extract in streptozotocin induced diabetic rats

    Institute of Scientific and Technical Information of China (English)

    Anusha Bhaskar; Anish Kumar

    2012-01-01

    Objective: To investigate the antihyperglycemic, hypolipidemic and antioxidant effects of aqueous and ethanolic flower extracts of Punica granatum (P. granatum) in streptozotocin (STZ) induced diabetes mellitus in wistar rats. Methods: Antihyperglycemic, hypolipidemic and antioxidant effect of P. granatum aqueous (PGFAet) and ethanolic extracts (PGFEet) at doses of 200 and 400 mg/kg bw was evaluated in streptozotocin induced diabetic rats. Glycosylated hemoglobin, plasma insulin, cholesterol and lipoprotein levels, lipid peroxide levels and the antioxidant enzyme levels were determined. Results: The administration of the extracts markedly reduced blood glucose and glycosylated hemoglobin increased the levels of plasma insulin and liver glycogen. The extract also had a hypolipidemic activity decreasing the levels of total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglycerides. The levels of lipid peroxides in terms of thiobarbituric acid reactive substances (TBARS) were remarkably reduced and the activities of the enzymes SOD, CAT and GPx and GSH were increased. We also saw an increase in the activity of the enzyme glucokinase and decrease in glucose-6-phosphatase. It can be concluded that the flower extracts of P. granatum (PGFAet and PGFEet) has significant restorative effect on the blood glucose, hyperlipidemia and oxidative stress. Conclusions: It can be concluded from the studies that the ethanolic extracts of the flowers of P. granatum at dosage 400 mg/kg/day exhibit significant effect in lowering blood sugar and lipid levels and increasing the antioxidant enzymes when compared to the aqueous extract. Glycosylated hemoglobin levels were reduced and the extract exhibited a stimulatory effect on insulin.

  3. A Traveling Exhibit of Cassini Image Science

    Science.gov (United States)

    Burns, Joseph A.; Hedman, M. M.; Tiscareno, M. S.; Ebel, D.; Mac Low, M.; Lovett, L. E.; Burns, J. K.; Schaff, N.; Bilson, E. M.

    2007-10-01

    An exhibit of Cassini's images will open at NYC's American Museum of Natural History in March 2008 and then visit the Johnson Art Museum (Cornell) throughout fall 2008, including during next year's DPS. It is under consideration by several other venues in the States and overseas. The exhibit will feature 40-50 images, ranging from letter size to large posters, taken by remote-sensing instruments aboard Cassini and Huygens. Photos will be organized into a half-dozen thematic clusters (e.g., organized by celestial target or by physical process); a panel will introduce each grouping with individual images identified briefly. The Saturn system is a perfect vehicle to educate citizens about planetary science and origins. The images’ beauty should capture the public's attention, allowing us to then engage their curiosity about the relevant science. Among the Saturn system's broad suite of objects are Enceladus and Titan, two satellites of astrobiological interest; moreover, the rings display many processes active in other astrophysical disks. Several auxiliary ideas will be implemented. In Ithaca, we will project images at night against the museum's sand-colored exterior walls. A 10-12 minute musical composition has been commissioned from Roberto Sierra to open the show. We will encourage school children to participate in a human orrery circling the museum and will seek volunteers to participate in several Saturnalia. At Cornell we will involve the university and local communities, by taping their reactions to the images’ exquisite beauty as well as to their scientific content. Cassini will be the E/PO focus of next year's DPS meeting; those materials will be employed throughout the fall at New York schools and be available to travel with the show. We intend to work with NYC partners to offer teacher credits for associated weekend courses. We will produce classroom materials, including a DVD, for teacher use.

  4. Hepatoprotective properties of Bauhinia variegata bark extract.

    Science.gov (United States)

    Bodakhe, Surendra H; Ram, Alpana

    2007-09-01

    Bauhinia variegata (Leguminosae) commonly known as Kachnar, is widely used in Ayurveda as tonic to the liver. The present work was carried out to assess the potential of Bauhinia variegata bark as hepatoprotective agent. The hepatoprotective activity was investigated in carbon tetrachloride (CCl(4)) intoxicated Sprague-Dawley rats. Bauhinia variegata alcoholic Stem Bark Extract (SBE) at different doses (100 and 200 mg/kg) were administered orally to male Sprague-Dawley rats weighing between 100-120 g. The effect of SBE on the serum marker enzymes, viz., AST, ALT, ALP and GGT and liver protein and lipids were assessed. The extract exhibited significant hepatoprotective activity. Hence, B. variegata appears to be a promising hepatoprotective agent.

  5. Analysis of antifungal and anticancer effects of the extract from Pelargonium zonale.

    Science.gov (United States)

    Lewtak, Kinga; Fiołka, Marta J; Szczuka, Ewa; Ptaszyńska, Aneta A; Kotowicz, Natalia; Kołodziej, Przemysław; Rzymowska, Jolanta

    2014-11-01

    The extract from Pelargonium zonale stalks exhibits activity against Candida albicans and exerts an effect on the HeLa cell line. The action against C. albicans cells was analysed using light, CLSM, SEM, and TEM microscopes. The observations indicate that the extract influenced fungal cell morphology and cell metabolic activity. The morphological changes include cell wall damage, deformations of cell surfaces, and abnormalities in fungal cell shape and size. Cells of C. albicans treated with the extract exhibited disturbances in the budding pattern and a tendency to form agglomerates and multicellular chains. The P. zonale extract caused a significant decrease in the metabolic activity of C. albicans cells. Cells died via both apoptosis and necrosis. The antitumor activity of the extract was analysed using the MTT assay. The P. zonale extract exhibited minor cytotoxicity against the HeLa cell line but a dose-dependent cytopathic effect was noticed. The P. zonale extract is a promising source for the isolation of antifungal and anticancer compounds.

  6. Electromembrane extraction

    DEFF Research Database (Denmark)

    Huang, Chuixiu; Chen, Zhiliang; Gjelstad, Astrid

    2017-01-01

    Electromembrane extraction (EME) was inspired by solid-phase microextraction and developed from hollow fiber liquid-phase microextraction in 2006 by applying an electric field over the supported liquid membrane (SLM). EME provides rapid extraction, efficient sample clean-up and selectivity based...

  7. Vacuum extraction

    DEFF Research Database (Denmark)

    Maagaard, Mathilde; Oestergaard, Jeanett; Johansen, Marianne

    2012-01-01

    Objectives. To develop and validate an Objective Structured Assessment of Technical Skills (OSATS) scale for vacuum extraction. Design. Two part study design: Primarily, development of a procedure-specific checklist for vacuum extraction. Hereafter, validationof the developed OSATS scale for vacuum...... extraction in a prospective observational study. Setting. Rigshospitalet, University Hospital of Copenhagen. Population. For development an obstetric expert from each labor ward in Denmark (28 departments) were invited to participate. For validation nine first-year residents and ten chief physicians...... with daily work in the obstetric field were tested. Methods. The Delphi method was used for development of the scale. In a simulated vacuum extraction scenario first-year residents and obstetric chief physicians were rated using the developed OSATS scale for vacuum extraction to test construct validity...

  8. Vacuum extraction

    DEFF Research Database (Denmark)

    Maagaard, Mathilde; Oestergaard, Jeanett; Johansen, Marianne

    2012-01-01

    Objectives. To develop and validate an Objective Structured Assessment of Technical Skills (OSATS) scale for vacuum extraction. Design. Two part study design: Primarily, development of a procedure-specific checklist for vacuum extraction. Hereafter, validationof the developed OSATS scale for vacuum...... extraction in a prospective observational study. Setting. Rigshospitalet, University Hospital of Copenhagen. Population. For development an obstetric expert from each labor ward in Denmark (28 departments) were invited to participate. For validation nine first-year residents and ten chief physicians...... with daily work in the obstetric field were tested. Methods. The Delphi method was used for development of the scale. In a simulated vacuum extraction scenario first-year residents and obstetric chief physicians were rated using the developed OSATS scale for vacuum extraction to test construct validity...

  9. Postprandial glycaemia and inhibition of α-glucosidase activity by aqueous extract from Coriandrum sativum.

    Science.gov (United States)

    Brindis, F; González-Andrade, M; González-Trujano, M E; Estrada-Soto, S; Villalobos-Molina, R

    2014-01-01

    The antihyperglycaemic properties of the aqueous extract from the leaves and stems of Coriandrum sativum L. were evaluated in normoglycaemic rats, and on α-glucosidase activity from Saccharomyces cerevisiae, in order to validate its use in folk medicine. In in vivo experiments rats were administered with the aqueous extract of the plant at 100, 300 and 500 mg/kg, to observe the effect on oral sucrose tolerance test. The aqueous extract exhibited significant antihyperglycaemic activity at the three tested doses. In vitro experiments with α-glucosidase exhibited a competitive-type inhibition. These results confirm the antidiabetic properties of the extract of C. sativum L., probably by the inhibition of α-glucosidase in the gastrointestinal tract.

  10. Behavioral and electroantennogram responses of plum curculio, Conotrachelus nenuphar, to selected noxious plant extracts and insecticides.

    Science.gov (United States)

    Gӧkçe, A; Stelinski, L L; Nortman, D R; Bryan, W W; Whalon, M E

    2014-01-01

    Behavioral and electroantennogram responses of plum curculio, Conotrachelus nenuphar (Herbst) (Coleoptera: Curculionidae), adults were tested for several methanolic plant extracts and organically approved insecticides. Plant extracts were evaluated for their potential as antifeedants or oviposition deterrents. These extract responses were also compared to those elicited by the non-neurotoxic, organic irritant-insecticide kaolin clay. Both sexes of plum curculio exhibited antennal response as measured by electroantennogram, which ranged from 0.2 to 1.1 mV, to plant extracts and the organic irritant/insecticide, with the greatest response to the extract of rough cocklebur, Xanthium strumarium L. (1.1 mV). No choice tests were conducted to compare feeding and oviposition by plum curculio on untreated apples or on apples treated with one of the extracts or the insecticide. The insecticide pyrethrum and extracts of X. strumarium and greater burdock, Arctium lappa L., significantly reduced feeding. Also, pyrethrum, A. lappa, Humulus lupulus L. (common hop), X. strumarium, and Verbascum songaricum Schrenk extracts completely inhibited egg deposition. In no-choice assays, the effects of kaolin clay with incorporated plant extracts on plum curculio feeding and oviposition were monitored as complementary tests. A. lappa-kaolin, H. lupulus-kaolin, and X. strumarium-kaolin mixtures significantly reduced the feeding of plum curculio compared to the control or kaolin clay alone. Each of the plant extract-kaolin mixtures evaluated, with the exception of Bifora radians Bieberstein (wild bishop), completely inhibited plum curculio oviposition as compared to controls.

  11. Total phenolic content and antioxidant activity of myrtle (Myrtus communis) extracts.

    Science.gov (United States)

    Amensour, Mahassine; Sendra, Esther; Abrini, Jamal; Bouhdid, Samira; Pérez-Alvarez, José Angel; Fernández-López, Juana

    2009-06-01

    The total phenolic content and antioxidant activity of methanolic, ethanolic and aqueous extracts of myrtle (Myrtus communis) leaves and berries were measured to find new potential sources of natural antioxidants. Total phenolic content was assessed by the Folin-Ciocalteau assay, while the antioxidant activity was evaluated by three methods: diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity assay, the reducing antioxidant power assay and beta-carotene linoleic acid assay. The total phenol content of myrtle extracts ranged between 9.0 and 35.6 mg GAE per g extract. For each solvent, leaf extracts contained significantly higher amount of total phenolic compounds than berry extracts. All of the extracts presented antioxidant capacity assessed by the three methods, but at different levels depending on the concentration, the extraction solvent and the part of the plant used. Generally, leaf extracts showed higher antioxidant activities than berry extracts, while the overall antioxidant strength was in the order methanol > water > ethanol in leaf extracts and methanol > ethanol > water in berry extracts. The phenolic content exhibited a positive correlation with the antioxidant activity: DPPH assay showed the highest correlation (r = 0.949), followed by the reducing power assay (r = 0.914) and the lowest for the beta-carotene linoleic acid assay (r = 0.722).

  12. Protective efficacy of Solanum xanthocarpum root extracts against free radical damage: phytochemical analysis and antioxidant effect.

    Science.gov (United States)

    Kumar, S; Sharma, U K; Sharma, A K; Pandey, A K

    2012-12-22

    Free radicals have been implicated in many diseases. They attack biological macromolecules in healthy human cells and cause protein and DNA damage along with lipid peroxidation. Present study reports the phytochemical analysis as well as free radical scavenging and antioxidant activities of Solanum xanthocarpum root extracts. Tannins, flavonoids, terpenoids, alkaloids, saponins and steroids were present in different extracts. Total flavonoid content in extracts was quantified and maximum contents were found in ethyl acetate fraction followed by chloroform and ethyl alcohol fractions, respectively. Dose dependent response was observed in metal ion chelating activity of extracts. Comparatively better chelating activity was found in polar extracts. Most of the extracts exhibited significant free radical scavenging activity in DPPH radical scavenging assay. Ethanolic and aqueous extracts accounted for about 40—50% lipid peroxidation inhibition (LPOI) in rat liver homogenate. Antioxidant activity did not show direct correlation with the amount of flavonoid contents in the extracts. However, direct correlation was observed between DPPH free radical scavenging activity and LPOI. Antioxidant activity of the extracts was compared with standard antioxidants. The differential activity observed in extracts could be attributed to the presence of other phytochemicals such as tannins and terpenoids in addition to flavonoids. The study demonstrated appreciable protective efficacy in S. xanthocarpum root extracts against free radical damage.

  13. Antioxidant and Anti-Cancer Potentials of Rheum emodi Rhizome Extracts

    Directory of Open Access Journals (Sweden)

    Venkatadri Rajkumar

    2011-01-01

    Full Text Available The objective of this study was to determine antioxidant and cytotoxic efficacies of methanolic and aqueous extracts of Rheum emodi Wall. ex Meissn. rhizome. 2,2-Diphenyl-1-picrylhydrazyl (DPPH and hydroxyl radical scavenging activities, inhibitory effect on lipid peroxidation and Fe3+ reducing antioxidant property have been used to investigate antioxidant properties of the extracts. Cytotoxicity of the extracts was tested on MDA-MB-435S and Hep3B cell lines. Both extracts displayed extensive cytotoxicity to the tested cell lines. The extracts were studied for their ability to protect pBR322 DNA from damage by UV induced photolysis of H2O2. The aqueous extract, though inferior to methanolic extract in its antioxidant potential exhibited efficiency in DNA protection, while the methanolic extract failed to protect the DNA. The amount of total polyphenolics in the extracts was measured by spectrophotometric method. The methanolic extract contained higher polyphenolic contents than aqueous extract. Significant positive correlations were observed (P < .05 between results of phenolic content estimation and that of antioxidant assays. Hence, high-performance liquid chromatography analysis was performed to identify few major phenolic compounds that might be responsible for these therapeutic properties. These results indicate that rhizome of R. emodi possesses antioxidant and cytotoxic activities and therefore have therapeutic potential.

  14. Hawthorn Fruit Extract Elevates Expression of Nrf2/HO-1 and Improves Lipid Profiles in Ovariectomized Rats.

    Science.gov (United States)

    Yoo, Jeong-Hyun; Liu, Yanan; Kim, Hyun-Sook

    2016-05-13

    The purpose of this study was to investigate the effects of hawthorn (Crataegus pinnatifida Bunge) extract on the lipid profiles and antioxidant properties in ovariectomized (OVX) rats. After ovariectomy, the rats were randomly divided into four groups: the non-OVX control (Sham), the OVX-control (OVX), the OVX + 100 mg/kg b.w. of hawthorn extract (OL), and the OVX + 200 mg/kg b.w. of hawthorn extract (OH). The final body weights of the OVX group were significantly increased, but the increment was significantly decreased in hawthorn groups (p hawthorn groups showed a significant decrease in these levels (p hawthorn groups compared with the OVX group (p hawthorn groups exhibited a significant increase in expression (p hawthorn extract reversed the suppression of protein levels. These results suggest that hawthorn extract could have protective effects in OVX rats by improving lipid profiles, decreasing oxidative stress, and improving the antioxidant defense system.

  15. Modern museum exhibition technology revolution for audience

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Today's digital revolution leads to the increasing mobile device usage, which has changed people's life and work. However, the traditional static display and graphic version is unable to meet the requirements of the modern audience, which makes museums face the challenge in the distribution of knowledge. Meanwhile, the information storm produced by big data emerged a variety of new media, such as social media, Natural User Interface, Augmented Reality, and electronic publishing. This dizzying array of tools offered opportunities for museums all over the world to become more vibrant and accessible. Museums around the world have been constant changed and improved its presentation, which provides a valuable experience for us. The new Shanghai Natural History Museum has also applied information technology on exhibition, education, research and collection. But the change does not mean a complete subversion. Because the museum audience are di- verse, such as born in a different era, have different learning habits, museums need to control the change magnitude of display technology to meet the requirements of different audience.

  16. Rotating pigment cells exhibit an intrinsic chirality.

    Science.gov (United States)

    Yamanaka, Hiroaki; Kondo, Shigeru

    2015-01-01

    In multicellular organisms, cell properties, such as shape, size and function are important in morphogenesis and physiological functions. Recently, 'cellular chirality' has attracted attention as a cellular property because it can cause asymmetry in the bodies of animals. In recent in vitro studies, the left-right bias of cellular migration and of autonomous arrangement of cells under some specific culture conditions were discovered. However, it is difficult to identify the molecular mechanism underlying their intrinsic chirality because the left-right bias observed to date is subtle or is manifested in the stable orientation of cells. Here, we report that zebrafish (Danio rerio) melanophores exhibit clear cellular chirality by unidirectional counterclockwise rotational movement under isolated conditions without any special settings. The chirality is intrinsic to melanophores because the direction of the cellular rotation was not affected by the type of extracellular matrix. We further found that the cellular rotation was generated as a counter action of the clockwise movement of actin cytoskeleton. It suggested that the mechanism that directs actin cytoskeleton in the clockwise direction is pivotal for determining cellular chirality.

  17. Echinacea purpurea-derived alkylamides exhibit potent anti-inflammatory effects and alleviate clinical symptoms of atopic eczema.

    Science.gov (United States)

    Oláh, Attila; Szabó-Papp, Judit; Soeberdt, Michael; Knie, Ulrich; Dähnhardt-Pfeiffer, Stephan; Abels, Christoph; Bíró, Tamás

    2017-05-27

    Atopic eczema (AE) is a chronic inflammatory and pruritic skin disease. There is still an unmet need for topical anti-inflammatory and anti-pruritic substances exhibiting an excellent safety profile. The endocannabinoid system is known to regulate various aspects of cutaneous barrier and immune functions, thus targeting it may be a valid approach for alleviating the symptoms of AE. To assess the putative efficacy of Echinacea purpurea-derived alkylamides (Ec. extract) activating cannabinoid (CB)-2 receptors in exerting anti-inflammatory effects and alleviating symptoms of AE. In vitro anti-inflammatory efficiency was investigated by monitoring the effects of Ec. extract on poly-(I:C)-induced pro-inflammatory cytokine expression (Q-PCR) and release (ELISA) of HaCaT keratinocytes. Irritancy and sensitization potential (assessed by Human Repeat Insult Patch Test; Clinical trial 1); clinical efficiency in alleviating symptoms of AE (Clinical trial 2) as well as effects on human skin structure and lipid content (Clinical trial 3 followed by transmission electron microscopy and HPTLC) were investigated in randomized double blind clinical trials. Ec. extract significantly reduced mRNA expression as well as release of poly-(I:C)-induced pro-inflammatory cytokines (IL-6 and IL-8) in keratinocytes. Thus, not surprisingly, the well-tolerated (Clinical trial 1) Ec. extract-based cream reduced local SCORAD statistically significantly, not only compared to baseline, but also compared to the comparator (Clinical trial 2). Of great importance, besides the in vitro anti-inflammatory effects, administration of the Ec. extract-based cream also resulted in significantly higher levels of overall epidermal lipids, ceramide EOS (ω-esterified fatty acid+sphingosine sphingoid base), and cholesterol at Day 15 compared to baseline as well as significantly greater numbers of intercellular lipid lamellae in the intercellular space (Clinical trial 3). The investigated Ec. extract shows great

  18. Environmental enrichment for a mixed-species nocturnal mammal exhibit.

    Science.gov (United States)

    Clark, Fay E; Melfi, Vicky A

    2012-01-01

    Environmental enrichment (EE) is an integral aspect of modern zoo animal management but, empirical evaluation of it is biased toward species housed in single-species groups. Nocturnal houses, where several nocturnal species are housed together, are particularly overlooked. This study investigated whether three species (nine-banded armadillos, Dasypus novemcinctus; Senegal bush babies, Galago senegalensis; two-toed sloths, Choloepus didactylus) in the nocturnal house at Paignton Zoo Environmental Park, UK could be enriched using food-based and sensory EE. Subjects were an adult male and female of each species. EE was deemed effective if it promoted target species-typical behaviors, behavioral diversity, and increased use of enriched exhibit zones. Results from generalized linear mixed models demonstrated that food-based EE elicited the most positive behavioral effects across species. One set of food-based EEs (Kong®, termite mound and hanging food) presented together was associated with a significant increase in species-typical behaviors, increased behavioral diversity, and increased use of enriched exhibit zones in armadillos and bush babies. Although one type of sensory EE (scented pine cones) increased overall exhibit use in all species, the other (rainforest sounds) was linked to a significant decrease in species-typical behavior in bush babies and sloths. There were no intra or interspecies conflicts over EE, and commensalism occurred between armadillos and bush babies. Our data demonstrate that simple food-based and sensory EE can promote positive behavioral changes in a mixed-species nocturnal mammal exhibit. We suggest that both food and sensory EE presented concurrently will maximize opportunities for naturalistic activity in all species.

  19. Multimedia Information Extraction

    CERN Document Server

    Maybury, Mark T

    2012-01-01

    The advent of increasingly large consumer collections of audio (e.g., iTunes), imagery (e.g., Flickr), and video (e.g., YouTube) is driving a need not only for multimedia retrieval but also information extraction from and across media. Furthermore, industrial and government collections fuel requirements for stock media access, media preservation, broadcast news retrieval, identity management, and video surveillance.  While significant advances have been made in language processing for information extraction from unstructured multilingual text and extraction of objects from imagery and vid

  20. Hepatoprotective activity of Ficus carica Linn leaf extract against carbon tetrachloride-induced hepatotoxicity in rats

    Directory of Open Access Journals (Sweden)

    Mohan G.K.

    2007-06-01

    Full Text Available The methanol extract of the leaves of Ficus carica Linn. (Moraceae was evaluated for hepatoprotective activity in rats with liver damage induced by carbon tetrachloride. The extract at an oral dose of 500 mg/kg exhibited a significant protective effect by lowering the serum levels of aspartate aminotransferase, alanine aminotransferase, total serum bilirubin, and malondialdehyde equivalent, an index of lipid peroxidation of the liver. These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of silymarin, a known hepatoprotective. 

  1. Screening for antimicrobial activity of crude drug extracts and pure natural products from Mexican medicinal plants.

    Science.gov (United States)

    Rojas, A; Hernandez, L; Pereda-Miranda, R; Mata, R

    1992-01-01

    Preliminary antimicrobial screening against Candida albicans and selected Gram-positive and Gram-negative bacteria of methanol extracts prepared from eight Mexican medicinal plants, noted for their antiseptic properties, was conducted. The significant activity exhibited for extracts of Ratibida latipalearis, Teloxys graveolens, Dodonaea viscosa, Hyptis albida, H. pectinata, H. Suaveolens and H. verticillata tends to support their traditional use as anti-infective agents. Only the extract of Hintonia latiflora was inactive. The antimicrobial activities of 44 pure natural compounds and two derivatives were determined. Of these, only 23 compounds were effective in inhibiting the growth of the tested organisms (MIC less than or equal to 100 micrograms/ml).

  2. Radical scavenging and antibacterial activity of Arnebia benthamii methanol extract

    Institute of Scientific and Technical Information of China (English)

    Showkat A Ganie; Asima Jan; Sabeera Muzaffar; Bilal A Zargar; Rabia Hamid; M Afzal Zargar

    2012-01-01

    Objective:To evaluate in vitro antioxidant and antibacterial activity of methanolic extract of Arnebia benthamii (A. benthamii) whole plant. Methods: Plasmid damage was analyzed by agarose gell electrophoresis. Calf thymus DNA was monitored by TBARS formation. DPPH, reducing power and lipid peroxidation was evaluated by using standard procedures. Antibacterial assay was monitored by disc diffusion method. Results: DPPH radical scavenging and hydroxyl radical scavenging potential of the plant revealed that the extract to be active radical scavenger. Reducing (Fe3+-Fe2+) power and lipid peroxidation inhibition efficiency (TBARS assay) of the extract was also evaluated and the extract showed promising activity in preventing lipid peroxidation and might prevent oxidative damages to biomolecules. The extract offered a significant protection against plasmid and calf thymus DNA damage induced by hydroxyl radicals. The extract was also evaluated on different bacterial strains and the maximum antibacterial activity was exhibited against Escherichia coli (E. coli) when compared with standard drug. Conclusions:These findings demonstrate that the methanol extract of A. benthamii has excellent anti-oxidant activities and could be considered as a potential source of lead molecules for pharmaceutical industries.

  3. Extraction, Characterization and Immunological Activity of Polysaccharides from Rhizoma gastrodiae

    Directory of Open Access Journals (Sweden)

    Juncheng Chen

    2016-06-01

    Full Text Available A response surface and Box-Behnken design approach was applied to augment polysaccharide extraction from the residue of Rhizoma gastrodiae. Statistical analysis revealed that the linear and quadratic terms for three variables during extraction exhibited obvious effects on extraction yield. The optimum conditions were determined to be a liquid-to-solid ratio of 54 mL/g, an extraction temperature of 74 °C, an extraction time of 66 min, and three extractions. These conditions resulted in a maximum Rhizoma gastrodiae polysaccharide (RGP extraction yield of 6.11% ± 0.13%. Two homogeneous polysaccharides (RGP-1a and RGP-1b were obtained using DEAE cellulose-52 and Sephadex G-100 columns. The preliminary characterization of RGP-1a and RGP-1b was performed using HPLC-RID, HPGPC, and FTIR. Tests of the immunological activity in vitro showed that the two polysaccharides could significantly stimulate macrophages to release NO and enhance phagocytosis in a dose-dependent manner. In particular, RGP-1b (200 μg/mL and LPS (2 μg/mL had almost the same influence on the NO production and phagocytic activity of RAW 264.7 macrophages (p > 0.05. All the data obtained indicate that RGP-1a and RGP-1b have the potential to be developed as a health food.

  4. Extraction, Characterization and Immunological Activity of Polysaccharides from Rhizoma gastrodiae.

    Science.gov (United States)

    Chen, Juncheng; Tian, Shan; Shu, Xiaoying; Du, Hongtao; Li, Na; Wang, Junru

    2016-06-25

    A response surface and Box-Behnken design approach was applied to augment polysaccharide extraction from the residue of Rhizoma gastrodiae. Statistical analysis revealed that the linear and quadratic terms for three variables during extraction exhibited obvious effects on extraction yield. The optimum conditions were determined to be a liquid-to-solid ratio of 54 mL/g, an extraction temperature of 74 °C, an extraction time of 66 min, and three extractions. These conditions resulted in a maximum Rhizoma gastrodiae polysaccharide (RGP) extraction yield of 6.11% ± 0.13%. Two homogeneous polysaccharides (RGP-1a and RGP-1b) were obtained using DEAE cellulose-52 and Sephadex G-100 columns. The preliminary characterization of RGP-1a and RGP-1b was performed using HPLC-RID, HPGPC, and FTIR. Tests of the immunological activity in vitro showed that the two polysaccharides could significantly stimulate macrophages to release NO and enhance phagocytosis in a dose-dependent manner. In particular, RGP-1b (200 μg/mL) and LPS (2 μg/mL) had almost the same influence on the NO production and phagocytic activity of RAW 264.7 macrophages (p > 0.05). All the data obtained indicate that RGP-1a and RGP-1b have the potential to be developed as a health food.

  5. Screening of antiangiogenic potential of twenty two marine invertebrate extracts of phylum Mollusca from South East Coast of India

    Institute of Scientific and Technical Information of China (English)

    Pankaj Gupta; Muthuvel Arumugam; Raj Vardhan Azad; Rohit Saxena; Supriyo Ghose; Nihar Ranjan Biswas; Thirumurthy Velpandian

    2014-01-01

    Objective: To evaluate the antiangiogenic potential of twenty two marine invertebrate species of Phylum Mollusca from south east coast of India.Methods:Live specimens of molluscan species were collected and their methanolic extracts were evaluated for preliminary antiangiogenic activity using the in ovo chick chorio-allantoic membrane assay. The extracts were further evaluated for in vivo antiangiogenic activity using chemical cautery induced corneal neovascularization assay in rats and oxygen induced retinopathy assay in rat pups.Results:In the chick chorio-allantoic membrane assay, four methanolic extracts of marine molluscan species viz. Meretrix meretrix, Meretrix casta, Telescopium telescopium and Bursacrumena methanolic extracts exhibited noticeable antiangiogenic activity at the tested concentration of 200 µg whereby they significantly inhibited the VEGF induced proliferation of new blood vessels. Among these four extracts, the methanolic extract of Meretrix casta exhibited relatively higher degree of antiangiogenic activity with an inhibitiory percentage (64.63%) of the VEGF induced neovascularization followed by the methanolic extracts of Telescopium telescopium (62.02%), Bursa crumena (60.48%) and Meretrix meretrix (47.01%). These four methanolic extracts were further evaluated for in vivo antiangiogenic activity whereby the methanolic extract of Telescopium telescopium exhibited most noticeable inhibition (42.58%) of the corneal neovascularization in rats in comparison to the sham treated group, and also exhibited most noticeable inhibition (31.31%) of the oxygen induced retinal neovascularization in rat pups in comparison to the hyperoxia group that was observed for considerable retinal neovascularization.Conclusions:The significant antiangiogenic activity evinced by the extract of Telescopium telescopium merits further investigation for ocular neovascular diseases.

  6. Evaluation of Bifenthrin and Acorus calamus Linn. Extract against Aedes aegypti L. and Aedes albopictus (Skuse

    Directory of Open Access Journals (Sweden)

    S Sulaiman

    2008-12-01

    Full Text Available "nBackground: Bifenthrin and Acorus calamus Linn extract were evaluated against dengue vectors in the laboratory."nMethods: Both Bifenthrin and Acorus calamus Linn crude hexane extract were bioassayed against the adults and larval stages of dengue vectors Aedes aegypti L. and Aedes albopictus(Skuse in the laboratory."nResults: The A. calamus crude hexane extract exhibited a larvicidal activity against 4th-instar Ae. aegypti larvae with LC50 and LC90 values of 0.4418 and 11.3935 ppm respectively. The plant crude extract exhibited against Ae. albopictus larvae with a higher LC50 and LC90 values of 21.2555 ppm and 36.1061 ppm, respectively. There was a significant difference on the effect of A. calamus extract on both Aedes spp. Larvae (P< 0.05. However, bifenthrin showed a significant difference on larvicidal effect to that of A. calamus hexane extract on both Aedes spp (P< 0.05. In testing the adulticidal activity, this plant extract exhibited the LC50 and LC90 values of 17.4075 and 252.9458 ppm against Ae .aegypti and a higher LC50 and LC90 values of 43.9952 and 446.1365 ppm respectively on Ae. albopictus. There was no significant difference on the effect of A. calamus extract on both Aedes spp adults (P> 0.05."nConclusion: Bifenthrin however showed a significant difference on both Aedes spp adults (P< 0.05. With the wide availability of A. calamus in Malaysia, it could be utilized for controlling dengue vectors. "n 

  7. Ceratonia siliqua L. hydroethanolic extract obtained by ultrasonication: antioxidant activity, phenolic compounds profile and effects in yogurts functionalized with their free and microencapsulated forms.

    Science.gov (United States)

    Rached, Irada; Barros, Lillian; Fernandes, Isabel P; Santos-Buelga, Celestino; Rodrigues, Alírio E; Ferchichi, Ali; Barreiro, Maria Filomena; Ferreira, Isabel C F R

    2016-03-01

    Bioactive extracts were obtained from powdered carob pulp through an ultrasound extraction process and then evaluated in terms of antioxidant activity. Ten minutes of ultrasonication at 375 Hz were the optimal conditions leading to an extract with the highest antioxidant effects. After its chemical characterization, which revealed the preponderance of gallotannins, the extract (free and microencapsulated) was incorporated in yogurts. The microspheres were prepared using an extract/sodium alginate ratio of 100/400 (mg mg(-1)) selected after testing different ratios. The yogurts with the free extract exhibited higher antioxidant activity than the samples added with the encapsulated extracts, showing the preserving role of alginate as a coating material. None of the forms significantly altered the yogurt's nutritional value. This study confirmed the efficiency of microencapsulation to stabilize functional ingredients in food matrices maintaining almost the structural integrity of polyphenols extracted from carob pulp and furthermore improving the antioxidant potency of the final product.

  8. Inhibition of Quorum Sensing-Controlled Virulence Factor Production in Pseudomonas aeruginosa PAO1 by Ayurveda Spice Clove (Syzygium Aromaticum Bud Extract

    Directory of Open Access Journals (Sweden)

    Kok-Gan Chan

    2012-03-01

    Full Text Available Quorum sensing controls the virulence determinants in most proteobacteria. In this work, the hexane, chloroform and methanol extracts of an Ayurveda spice, namely clove (Syzygium aromaticum, shown anti-quorum sensing activity. Hexane and methanol extracts of clove inhibited the response of C. violaceum CV026 to exogenously supplied N‑hexanoylhomoserine lactone, in turn preventing violacein production. Chloroform and methanol extracts of clove significantly reduced bioluminescence production by E. coli [pSB1075] grown in the presence of N-(3-oxododecanoyl-L-homoserine lactone. We demonstrated that clove extract inhibited quorum sensing-regulated phenotypes in Pseudomonas aeruginosa PA01, including expression of lecA::lux (by hexane extract, swarming (maximum inhibition by methanol extract, pyocyanin (maximum inhibition by hexane extract. This study shows that the presence of natural compounds that exhibit anti-quorum sensing activity in the clove extracts may be useful as the lead of anti-infective drugs.

  9. Antibacterial Curcuma xanthorrhiza Extract and Fractions

    Directory of Open Access Journals (Sweden)

    Hartiwi Diastuti

    2014-12-01

    Full Text Available An acetone extract of Curcuma xanthorrhiza rhizomes and the nhexane and chloroform fractions obtained from it were tested on eight pathogenic bacteria. The results showed that the acetone extract and the nhexane fraction exhibited significant activities against Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus, and weak activities against Shigella dysenteriae and Vibrio cholerae. They were inactive against Escherichia coli, Enterobacter aerogenes and Salmonella thypi, while the chloroform fraction was devoid of activities. NMR analysis disclosed the presence of α-curcumene, xanthorrhizol and an unknown monoterpene in the nhexane fraction. In the chloroform fraction, curcumin was found to be the main compound, together with xanthorrhizol as a minor compound. These results suggest that the antibacterial potency of acetone extract of C. xanthorrhiza is contained in the n-hexane fraction, in which the active constituents are terpenoid compounds. This is the first report of the use of NMR analysis for compound identification contained in an extract or fractions of C. xanthorrhiza.

  10. Effect of foliar application of selenium on the antioxidant activity of aqueous and ethanolic extracts of selenium-enriched rice.

    Science.gov (United States)

    Xu, Juan; Hu, Qiuhui

    2004-03-24

    Selenium fertilizer was foliar applied to determine the effects of antioxidant activity of selenium-enriched rice assessed by alpha,alpha-diphenyl-beta-picylhydrazyl (DPPH) radical scavenging and the ferric thiocyanate (FTC) method. Results showed that selenium concentration in rice was significantly enhanced dose dependently. Aqueous or ethanolic extracts of rice displayed significantly higher antioxidant activity against lipid peroxidation. The activities of aqueous extracts were significantly higher than those of ethanolic extracts and increased with the increasing selenium concentration in rice. The DPPH assay showed that the kinetic behaviors of aqueous extracts were complex and slow, while ethanolic extracts reacted quickly with DPPH radical. Aqueous extracts of rice exhibited higher antiradical efficiencies than ethanolic extracts, and rice (1.275 mg Se kg(-)(1)) presented the lowest EC(50) values of 533.46 +/- 0.58 microg mL(-)(1). As compared to rice extracts, all of the reference antioxidants showed more than 4-fold antiradical efficiencies than rice extracts. This radical scavenging activity was significantly correlated with selenium concentrations in rice (R = 0.862, p < 0.05), while ethanolic extracts were inversely correlated with selenium concentration in rice.

  11. Application of ultrasound in extractive metallurgy: Sonochemical extraction of nickel

    Science.gov (United States)

    Pesic, Batric; Zhou, Taili

    1992-01-01

    The importance of ultrasound in solvent extraction was examined by studying solvent extraction of nickel with Lix 65N and Lix 70 extractants. The studied parameters were ultrasonic energy and frequency, pH, temperature, and organic and aqueous solution composition. The stability of extractants under the influence of ultrasound was also examined. It was found that ultrasound had a significant importance, because it increased the extraction rates four- to sevenfold. The effect of ultrasound was physical, i.e., to increase the surface area. Ultrasonic energy consumption was also evaluated. The consumption was high, but it can be significantly reduced by the appropriate method of application. A novel solvent extraction method, extraction-in-pipe, was also proposed.

  12. HIV-1 inhibition by extracts of Clusiaceae species from Mexico.

    Science.gov (United States)

    Huerta-Reyes, Maira; Basualdo, Maria del Carmen; Lozada, Lucio; Jimenez-Estrada, Manuel; Soler, Carmen; Reyes-Chilpa, Ricardo

    2004-06-01

    The organic plant extracts of 21 species of Clusiaceae from Mexico were screened for anti HIV-1 reverse transcriptase activity in a non-radioactive immuno colorimetric assay. The extracts of 5 species (23.8%) exhibited significant inhibition (> or =70%) of HIV-1 RT activity; of these, only 4 extracts showed reduced toxicity to human lymphocytic MT2 cells and were further tested as inhibitors of HIV-1 IIIb/LAV replication in a cellular system. The best extracts were Calophyllum brasiliense (hexane) and Clusia quadrangula (CH(2)Cl(2)-MeOH) which inhibited HIV-1 RT (IC(50)=29.6 microg/ml and 42 microg/ml), and showed an EC(50)=92.5 microg/ml and 91 microg/ml, respectively, on MT2 cells. However, only Calophyllum brasiliense hexane extract showed significant inhibition on viral replication (ED(50)=37.1 microg/ml), while Clusia quadrangula was less active (ED(50)=124 microg/ml). These results support the idea that plant extracts represent a valuable source of potential anti HIV compounds.

  13. Volatile compounds of Lamiaceae exhibit a synergistic antibacterial activity with streptomycin

    Directory of Open Access Journals (Sweden)

    Sthéfane G. Araújo

    2014-12-01

    Full Text Available Bacterial infections cause thousands of deaths in the world every year. In most cases, infections are more serious because the patient is already weakened, and often, the bacteria are already resistant to the antibiotics used. Counterparting this negative scenario, the interest in medicinal plants as an alternative to the synthetic antimicrobial drugs is blossoming worldwide. In the present work, we identified the volatile compounds of ethanol extracts of Melissa officinalis, Mentha sp., Ocimum basilicum, Plectranthus barbatus, and Rosmarinus officinalis by gas chromatography/mass spectrometry (GC/MS. Also was evaluated antimicrobial activity of ethanol extracts against 6 bacteria of clinical interest, and was tested the interaction of these extracts with a commercial antibiotic streptomycin. Phytol was a compound identified in all extracts by GC/MS, being majoritary component in Plectranthus barbatus and Rosmarinus officinalis. The Gram-positive bacteria were more sensitive to ethanol extracts, and Plectranthus barbatus and Rosmarinus officinalis were the most active extracts. Ethanol extracts exhibited a synergetic effect with streptomycin. These results encourage additional studies, in order to evaluate the possibilities of using ethanol extracts of Lamiaceae family as natural source for antibacterial activity.

  14. Hepatoprotective and antioxidant activity of standardized herbal extracts

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    Deepak Bhaskarmurthy Hiraganahalli

    2012-01-01

    Full Text Available Background : Phyllanthus emblica, Camellia sinensis, Mangifera indica, Punica granatum, and Acacia catechu have been shown to possess widespread pharmacological application against multitude of diseases namely cancer, diabetes, liver disorders, and oxidative stress. Objective: We evaluated the hepatoprotective activity of the standardized herbal extracts against tert-butyl hydroperoxide (t-BH induced toxicity and their mechanism of hepatoprotective action in human hepatocarcinoma cells (HepG2 cell line. Materials and Methods: The hepatoprotective activity was studied by observing the effect of these herbal extracts on t-BH induced reduction in cell viability of HepG2 cells. In addition, the reducing power of the extracts and their ability to scavenge free radicals were evaluated using two antioxidant assay systems: cell free [oxygen radical absorbance capacity (ORAC, 2,2-diphenyl-1-picrylhydrazyl (DPPH, and [2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonicacid] (ABTS] and cell based [cellular antioxidant activity (CAA]. Results and Discussion: The results obtained showed that these extracts possess significant hepatoprotective activity. This may indicate that the plant extracts contain compounds, which can remove toxic metabolites following t-BH induced toxicity. The extracts exhibited significant antioxidant property as evident by the Trolox values and effective scavenging of DPPH and ABTS radicals. The extracts also demonstrated inhibition of AAPH-induced fluorescence in HepG2 cells. These results indicate the ability of the plant extracts to protect the liver cells from chemical-induced damage, which might be correlated to their radical scavenging potential. Conclusion: This study demonstrates that these extracts have potential hepatoprotective activity which is mainly attributed to the antioxidant potential, which might occur by reduction of lipid peroxidation and cellular damage.

  15. Antigenotoxic activities of crude extracts from Acacia salicina leaves.

    Science.gov (United States)

    Mansour, Hédi B; Boubaker, Jihed; Bouhlel, Inès; Mahmoud, Amor; Bernillon, Stéphane; Chibani, Jemni B; Ghedira, Kamel; Chekir-Ghedira, Leila

    2007-01-01

    For centuries, plants have been used in traditional medicines and there has been recent interest in the chemopreventive properties of compounds derived from plants. In the present study, we investigated the effects of extracts of Acacia salicina leaves on the genotoxicity of benzo[a]pyrene (B(a)P) and nifuroxazide in the SOS Chromotest. Aqueous, total oligomers flavonoids (TOF)-enriched, petroleum ether, chloroform, ethyl acetate, and methanol extracts were prepared from powdered Acacia leaves, and characterized qualitatively for the presence of tannins, flavonoids, and sterols. All the extracts significantly decreased the genotoxicity induced by 1 microg B(a)P (+S9) and 10 microg nifuroxazide (-S9). The TOF-enriched and methanol extracts decreased the SOS response induced by B(a)P to a greater extent, whereas the TOF-enriched and the ethyl acetate extracts exhibited increased activity against the SOS response produced by nifuroxazide. In addition, the aqueous, ethyl acetate, and methanol extracts showed increased activity in scavenging the 1,1-diphenyl- 2-picrylhydrazyl (DPPH) free radical, while 100-300 microg/ml of all the test extracts were active in inhibiting O2-production in a xanthine/xanthine oxidase system. In contrast, only the petroleum ether extract was effective at inhibiting nitroblue tetrazolium reduction by the superoxide radical in a nonenzymatic O2- -generating system. The present study indicates that extracts of A. salicina leaves are a significant source of compounds with antigenotoxic and antioxidant activity (most likely phenolic compounds and sterols), and thus may be useful for chemoprevention.

  16. Studies of biological properties of Uncaria tomentosa extracts on human blood mononuclear cells.

    Science.gov (United States)

    Bors, Milena; Michałowicz, Jaromir; Pilarski, Radosław; Sicińska, Paulina; Gulewicz, Krzysztof; Bukowska, Bożena

    2012-08-01

    between aqueous and ethanol extracts. It was observed that ethanol extracts exhibited stronger negative effects on mononuclear blood cells. The kind of extractant used had a significant influence of the chemical composition of the tested extracts. The ethanol extract from bark containing a high amount of polyphenols and alkaloids revealed the highest pro-apoptotic effect. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  17. STONETECH 2007 BEIJING Held At International Exhibition Center

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ On March 4-7, the 14th China International Stone Processing Machinery,Equipment and Products Exhibition (STONETECH 2007 BEIJING) was held in all exhibition halls of Beijing International Exhibition Center.

  18. In vitro antimicrobial activities of methanolic extract from marine alga Enteromorpha intestinalis

    Institute of Scientific and Technical Information of China (English)

    Ibrahim; Darah; Sheh-Hong; Lim

    2015-01-01

    Objective:To extract the bioactive compound from Enteromorpha intestinalis(E. intestinalis) and determine its in vitro antimicrobial activity. Methods: E. intestinalis was extracted by methanol and subjected to antimicrobial screening. The antimicrobial activity was studied by using disc diffusion and broth dilution method. The effect of the extract on the growth profile of the bacterial was also examined via time-kill assay. Microscopy observations using SEM was done to determine the major alterations in the microstructure of methicillin-resistant Staphylococcus aureus(MRSA). Results: The results showed methanolic extract of E. intestinalis exhibited a favourable antimicrobial activity against tested bacteria with produced inhibition zone ranging from 8.0-19.0 mm. However, all the tested fungi and yeast were resistant to the extract treatment. Time kill assay suggested that methanolic extract of E. intestinalis had completely inhibited MRSA growth and also exhibited prolonged antibacterial activity. The main abnormalities noted from the microscopic observations were the structural deterioration in the normal morphology and complete collapsed of the bacteria cells after 36 h of treatment. Conclusions: The significant antibacterial activity shown by crude extract suggested its potential against MRSA infection. The extract may have potential to develop as antibacterial agent in pharmaceutical use.

  19. Anti-inflammatory, cyclooxygenase inhibitory and antioxidant activities of standardized extracts of Tridax procumbens L.

    Science.gov (United States)

    Jachak, Sanjay M; Gautam, Raju; Selvam, C; Madhan, Himanshu; Srivastava, Amit; Khan, Taj

    2011-03-01

    The standardized EtOAc, MeOH and 70% EtOH extracts of Tridax procumbens aerial parts showed significant inhibition of rat paw edema at a medium dose of 200mg/kg and the EtOAC extract was the most active. These extracts were standardized by HPLC with the help of chemical markers. Further, the extracts were evaluated for COX-1 and COX-2 inhibitory activity and EtOAc extract exhibited the highest inhibition of COX-1 and COX-2 at 50 μg/mL. Cent aurein, centaureidin and bergenin were isolated as COX-1 and COX-2 inhibitory principles from the EtOAc extract. The extracts also exhibited antioxidant activity against DPPH and ABTS free radicals. The anti-inflammatory activity of T. procumbens aerial parts could be at least in part due to COX-1, COX-2 enzyme inhibition and free radical-scavenging activities which may be attributed to the presence of flavonoids and other polyphenols in the extracts.

  20. Antioxidant and antimicrobial activities of commercial rice wine extracts of Taiwanese Allium fistulosum.

    Science.gov (United States)

    Chang, Tsan-Chang; Jang, Hung-Der; Lin, Wang-De; Duan, Peng-Fu

    2016-01-01

    The antioxidant and antibacterial activities of commercial rice wine extracts obtained from different plant parts of Allium fistulosum were assayed. The results showed that commercial rice wine extracts of A. fistulosum contained 28.3-95.9 μL/mL allicin and exhibited significant antioxidant and antibacterial activities. The DPPH radical scavenging capacity ranged from 90.2% to 52.1%, and the IC50 value ranged from 14.6 to 26.0 μg/mL. The total phenolic content of wine extracts was 56.4-198.9 mg GAE/g extracts. The TEAC assay of extracts ranged from 6.2 to 15.5 mmol/g extracts. Antibacterial activities were tested against 4 bacteria b y using agar disc diffusion and tube dilution tests. All extracts exhibited antibacterial activities against gram-positive bacteria, such as Bacillus subtilis and Staphylococcus aureus, and gram-negative bacteria, such as Escherichia coli and Pseudomonas aeruginosa. Thus, A. fistulosum wine extracts could be used as natural and functional additives in cooking foods.