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Sample records for extra ocular muscles

  1. MAGNETIC RESONANCE IMAGING CONTRAST ENHANCEMENT OF EXTRA-OCULAR MUSCLES IN DOGS WITH NO CLINICAL EVIDENCE OF ORBITAL DISEASE

    NARCIS (Netherlands)

    JOSLYN, S.; Richards, S.; Boroffka, S.A.E.B.; Mitchell, M.; Hammond, G.; Sullivan, M.T.

    2013-01-01

    Enhancement of extra-ocular muscles has been reported in cases of orbital pathology in both veterinary and medical magnetic resonance imaging.We have also observed this finding in the absence of orbital disease. The purpose of this retrospective study was to describe extra-ocular muscle contrast enh

  2. MAGNETIC RESONANCE IMAGING CONTRAST ENHANCEMENT OF EXTRA-OCULAR MUSCLES IN DOGS WITH NO CLINICAL EVIDENCE OF ORBITAL DISEASE

    NARCIS (Netherlands)

    JOSLYN, S.; Richards, S.; Boroffka, S.A.E.B.; Mitchell, M.; Hammond, G.; Sullivan, M.T.

    2013-01-01

    Enhancement of extra-ocular muscles has been reported in cases of orbital pathology in both veterinary and medical magnetic resonance imaging.We have also observed this finding in the absence of orbital disease. The purpose of this retrospective study was to describe extra-ocular muscle contrast enh

  3. Extra-ocular muscle MRI in genetically-defined mitochondrial disease

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    Pitceathly, Robert D.S.; Morrow, Jasper M.; Hanna, Michael G. [UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, MRC Centre for Neuromuscular Diseases, London (United Kingdom); Sinclair, Christopher D.J.; Yousry, Tarek A.; Thornton, John S. [UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, MRC Centre for Neuromuscular Diseases, London (United Kingdom); UCL Institute of Neurology, Neuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, London (United Kingdom); Woodward, Cathy; Sweeney, Mary G. [National Hospital for Neurology and Neurosurgery, Neurogenetics Unit, London (United Kingdom); Rahman, Shamima [UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, MRC Centre for Neuromuscular Diseases, London (United Kingdom); UCL Institute of Child Health, Mitochondrial Research Group, Clinical and Molecular Genetics Unit, London (United Kingdom); Plant, Gordon T.; Ali, Nadeem [National Hospital for Neurology and Neurosurgery, Department of Neuro-ophthalmology, London (United Kingdom); Moorfields Eye Hospital, Department of Neuro-ophthalmology, London (United Kingdom); Bremner, Fion [National Hospital for Neurology and Neurosurgery, Department of Neuro-ophthalmology, London (United Kingdom); Davagnanam, Indran [National Hospital for Neurology and Neurosurgery, The Lysholm Department of Neuroradiology, London (United Kingdom)

    2016-01-15

    Conventional and quantitative MRI was performed in patients with chronic progressive external ophthalmoplegia (CPEO), a common manifestation of mitochondrial disease, to characterise MRI findings in the extra-ocular muscles (EOMs) and investigate whether quantitative MRI provides clinically relevant measures of disease. Patients with CPEO due to single mitochondrial DNA deletions were compared with controls. Range of eye movement (ROEM) measurements, peri-orbital 3 T MRI T1-weighted (T1w) and short-tau-inversion-recovery (STIR) images, and T2 relaxation time maps were obtained. Blinded observers graded muscle atrophy and T1w/STIR hyperintensity. Cross-sectional areas and EOM mean T2s were recorded and correlated with clinical parameters. Nine patients and nine healthy controls were examined. Patients had reduced ROEM (patients 13.3 , controls 49.3 , p < 0.001), greater mean atrophy score and increased T1w hyperintensities. EOM mean cross-sectional area was 43 % of controls and mean T2s were prolonged (patients 75.6 ± 7.0 ms, controls 55.2 ± 4.1 ms, p < 0.001). ROEM correlated negatively with EOM T2 (rho = -0.89, p < 0.01), whilst cross-sectional area failed to correlate with any clinical measures. MRI demonstrates EOM atrophy, characteristic signal changes and prolonged T2 in CPEO. Correlation between elevated EOM T2 and ROEM impairment represents a potential measure of disease severity that warrants further evaluation. (orig.)

  4. Lymphomas and metastases of the extra-ocular musculature

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    Surov, Alexey; Behrmann, Curd; Koesling, Sabrina [Martin Luther University of Halle-Wittenberg, Department of Radiology, Halle (Germany); Holzhausen, Hans-Juergen [Martin Luther University of Halle-Wittenberg, Department of Pathology, Halle (Germany)

    2011-11-15

    The involvement of extra-ocular muscles in malignant diseases has been described only sporadically. The purpose of this study was to estimate the prevalence of orbital muscle lymphoma and metastases and to analyse their radiological findings. In the time period from January 2000 to January 2010, 11 patients with extra-ocular muscle malignancies (EOMM) were retrospectively identified in the radiological database of our institution. There were four women and seven men with a median age of 58 years (range, 47 to 72 years). In three patients non-Hodgkin lymphoma (NHL), in seven cases intramuscular metastases of solid tumours and in one patient plasmacytoma of orbital muscles were diagnosed. In all, magnetic resonance imaging (MRI) was performed on 11 patients using a 1.5-T MRI scanner (Magnetom Vision Sonata Upgrade, Siemens, Germany). The diagnosis of EOMM was confirmed histopathologically by muscle biopsy in all cases. The prevalence of orbital muscle involvement in plasmacytoma was 0.3%, in NHL 0.4% and in carcinomas 0.1%. Clinically, EOMM presented as painless proptosis and motility disturbance. Medial and lateral rectus muscles were involved in most patients. On T2-weighted images, the lesions were isointense or mixed iso-to-hyperintense in comparison to the unaffected musculature. On T1-weighted images, all tumours were homogeneously isointense. After intravenous administration of contrast medium, most lesions showed moderate heterogeneous enhancement. Lymphomas and metastases are rare lesions of the extra-ocular musculature with a prevalence below 0.5%. Their radiological and clinical signs are non-specific and include painless muscle enlargement or masses. They should be considered in the differential diagnosis of diseases of extra-ocular muscles. (orig.)

  5. 4D-visualization of the orbit based on dynamic MRI with special focus on the extra-ocular muscles and the optic nerves

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    Kober, C. [Univ. of Applied Sciences Osnabrueck (Germany); Boerner, B.I.; Buitrago, C.; Klarhoefer, M.; Scheffler, K.; Kunz, C.; Zeilhofer, H.F. [Univ. Hospital Basle (Switzerland)

    2007-06-15

    By recording time dependent patients' behaviour, dynamic radiology is dedicated to capturing functional anatomy. Dynamic 'quasi-continuous' MRI data of lateral eye movements of a healthy volunteer were acquired using SE imaging sequence (Siemens, 1.5 T). By means of combined application of several image processing and visualization techniques, namely shaded and transparent surface reconstruction as well as direct volume rendering, 4D-visualization of the dynamics of the extra ocular muscles was possible. Though the original MRI data were quite coarse vascular structures could be recognized to some extent. For the sake of 4D-visualization of the optic nerve, the optic cavity was opened by axial clipping of the visualization. Superimposition of the original MRI slices to the visualization, either transparently or opaque, served as validation and comparison to conventional diagnosis. For facilitation of the analysis of the visualization results, stereoscopic rendering was rated as quite significant especially in the clinical setting. (orig.)

  6. Ocular and extra-ocular features of patients with Leber congenital amaurosis and mutations in CEP290

    NARCIS (Netherlands)

    Yzer, Suzanne; den Hollander, Anneke I.; Lopez, Irma; Pott, Jan-Willem R.; de Faber, Jan Tjeerd H. N.; Cremers, Frans P. M.; Koenekoop, Robert K.; van den Born, L. Ingeborgh

    2012-01-01

    Purpose: This study investigated the centrosomal protein, 290-KD (CEP290) associated genotype and ocular and extra-ocular phenotype in 18 patients with Leber congenital amaurosis (LCA). Methods: Eighteen patients with LCA from 14 families with mutations in the CEP290 gene were identified with sequen

  7. Ocular and extra-ocular features of patients with Leber congenital amaurosis and mutations in CEP290

    NARCIS (Netherlands)

    Yzer, S.; Hollander, A.I. den; Lopez, I.; Pott, J.W.; Faber, J.T. de; Cremers, F.P.; Koenekoop, R.K.; Born, L.I. van den

    2012-01-01

    PURPOSE: This study investigated the centrosomal protein, 290-KD (CEP290) associated genotype and ocular and extra-ocular phenotype in 18 patients with Leber congenital amaurosis (LCA). METHODS: Eighteen patients with LCA from 14 families with mutations in the CEP290 gene were identified with sequen

  8. Ocular and extra-ocular features of patients with Leber congenital amaurosis and mutations in CEP290

    NARCIS (Netherlands)

    Yzer, Suzanne; den Hollander, Anneke I.; Lopez, Irma; Pott, Jan-Willem R.; de Faber, Jan Tjeerd H. N.; Cremers, Frans P. M.; Koenekoop, Robert K.; van den Born, L. Ingeborgh

    2012-01-01

    Purpose: This study investigated the centrosomal protein, 290-KD (CEP290) associated genotype and ocular and extra-ocular phenotype in 18 patients with Leber congenital amaurosis (LCA). Methods: Eighteen patients with LCA from 14 families with mutations in the CEP290 gene were identified with sequen

  9. Atomic Force Microscopy Determination of Young’s Modulus of Bovine Extra-ocular Tendon Fiber Bundles

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    Yoo, Lawrence; Reed, Jason; Shin, Andrew; Demer, Joseph L.

    2014-01-01

    Extra-ocular tendons (EOTs) transmit the oculorotary force of the muscles to the eyeball to generate dynamic eye movements and align the eyes, yet the mechanical properties of the EOTs remain undefined. The EOTs are known to be composed of parallel bundles of small fibers whose mechanical properties must be determined in order to characterize the overall behavior of EOTs. The current study aimed to investigate the transverse Young’s modulus of EOT fiber bundles using atomic force microscopy (AFM). Fresh bovine EOT fiber bundle specimens were maintained under temperature and humidity control, and indented 100 nm by the inverted pyramid tip of an AFM (Veeco Digital Instruments, NY). Ten indentations were conducted for each of 3 different locations of 10 different specimens from each of 6 EOTs, comprising a total of 1,800 indentations. Young’s modulus for each EOT was determined using a Hertzian contact model. Young’s moduli for fiber bundles from all six EOTs were determined. Mean Young’s moduli for fiber bundles were similar for the six anatomical EOTs: lateral rectus 60.12 ± 2.69 (±SD) MPa, inferior rectus 59.69 ± 5.34 MPa, medial rectus 56.92 ±1.91 MPa, superior rectus 59.66 ±2.64 MPa, inferior oblique 57.7± 1.36 MPa, and superior oblique 59.15± 2.03. Variation in Young’s moduli among the six EOTs was not significant (P > 0.25). The Young’s modulus of bovine EOT fibers is highly uniform among the six extraocular muscles, suggesting that each EOT is assembled from fiber bundles representing the same biomechanical elements. This uniformity will simplify overall modeling. PMID:24767704

  10. Tendinous muscle insertions (scleromuscular junctions of the recti muscles) in patients with ocular alignment problems.

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    Todorova, M G; Palmowski-Wolfe, A M; Meyer, P

    2015-04-01

    The purpose of this study was to prove the hypothesis whether the scleromuscular junction of extraocular recti muscle is tendinous. Muscle samples of the 41 extraocular recti muscles of 33 patients and 4 muscle-/eye-matched samples from 2 postmortem eyes, were processed for light/electron microscopy and immunohistochemistry with antibodies against desmin, smooth-muscle actin and muscle regulating proteins like myf3 and myf4 (myogenin), tenascin C and for 8 samples against collagens I to IV. Histological examination of the muscle samples confirmed a thick collagen-structured tissue, specific for muscle tendon; without appearance of muscle tissue. This was confirmed by immunohistochemistry with antibodies against desmin, smooth-muscle actin, myf3 and myf4 (myogenin) and for eight samples with collagens I to IV. Anti-tenascin C marker was only strongly positive in the connective tissue of the blood vessel walls. Electron microscopy demonstrated collagen bundles composed of parallel oriented fibrils with a moderate amount of ground substance. The absence of contractile fibers at the sclerotendinous junction is an entirely normal finding in humans and cannot be related to ocular alignment pathogenesis. Georg Thieme Verlag KG Stuttgart · New York.

  11. Mechanisms causing effects of muscle position on proximo-distal muscle force differences in extra-muscular myofascial force transmission.

    NARCIS (Netherlands)

    Yucesoy, C.A.; Maas, J.H.; Maas, Huub; Koopman, Hubertus F.J.M.; Grootenboer, H.J.; Huijing, P.A.J.B.M.

    2006-01-01

    Certain recent studies showed that extra-muscular myofascial force transmission affects the length–force characteristics of rat extensor digitorium longus (EDL) muscle significantly after distal or proximal lengthening. This suggested that the relative position of a muscle with respect to its

  12. Vibration-induced extra torque during electrically-evoked contractions of the human calf muscles

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    Kohn André F

    2010-06-01

    Full Text Available Abstract Background High-frequency trains of electrical stimulation applied over the lower limb muscles can generate forces higher than would be expected from a peripheral mechanism (i.e. by direct activation of motor axons. This phenomenon is presumably originated within the central nervous system by synaptic input from Ia afferents to motoneurons and is consistent with the development of plateau potentials. The first objective of this work was to investigate if vibration (sinusoidal or random applied to the Achilles tendon is also able to generate large magnitude extra torques in the triceps surae muscle group. The second objective was to verify if the extra torques that were found were accompanied by increases in motoneuron excitability. Methods Subjects (n = 6 were seated on a chair and the right foot was strapped to a pedal attached to a torque meter. The isometric ankle torque was measured in response to different patterns of coupled electrical (20-Hz, rectangular 1-ms pulses and mechanical stimuli (either 100-Hz sinusoid or gaussian white noise applied to the triceps surae muscle group. In an additional investigation, Mmax and F-waves were elicited at different times before or after the vibratory stimulation. Results The vibratory bursts could generate substantial self-sustained extra torques, either with or without the background 20-Hz electrical stimulation applied simultaneously with the vibration. The extra torque generation was accompanied by increased motoneuron excitability, since an increase in the peak-to-peak amplitude of soleus F waves was observed. The delivery of electrical stimulation following the vibration was essential to keep the maintained extra torques and increased F-waves. Conclusions These results show that vibratory stimuli applied with a background electrical stimulation generate considerable force levels (up to about 50% MVC due to the spinal recruitment of motoneurons. The association of vibration and electrical

  13. Single motor unit activity in human extraocular muscles during the vestibulo-ocular reflex.

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    Weber, Konrad P; Rosengren, Sally M; Michels, Rike; Sturm, Veit; Straumann, Dominik; Landau, Klara

    2012-07-01

    Motor unit activity in human eye muscles during the vestibulo-ocular reflex (VOR) is not well understood, since the associated head and eye movements normally preclude single unit recordings. Therefore we recorded single motor unit activity following bursts of skull vibration and sound, two vestibular otolith stimuli that elicit only small head and eye movements. Inferior oblique (IO) and inferior rectus (IR) muscle activity was measured in healthy humans with concentric needle electrodes. Vibration elicited highly synchronous, short-latency bursts of motor unit activity in the IO (latency: 10.5 ms) and IR (14.5 ms) muscles. The activation patterns of the two muscles were similar, but reciprocal, with delayed activation of the IR muscle. Sound produced short-latency excitation of the IO muscle (13.3 ms) in the eye contralateral to the stimulus. Simultaneous needle and surface recordings identified the IO as the muscle of origin of the vestibular evoked myogenic potential (oVEMP) thus validating the physiological basis of this recently developed clinical test of otolith function. Single extraocular motor unit recordings provide a window into neural activity in humans that can normally only be examined using animal models and help identify the pathways of the translational VOR from otoliths to individual eye muscles.

  14. Tear function and ocular surface after Muller muscle-conjunctival resection.

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    Uğurbaş, Suat Hayri; Alpay, Atilla; Bahadır, Burak; Uğurbaş, Sılay Cantürk

    2014-05-01

    Muller muscle-conjunctival resection (MCR) is a surgical technique to correct mild and moderate ptosis. In this study, tear function tests and ocular surface are evaluated in patients who underwent unilateral surgery. Sixteen patients with normal preoperative tear function who underwent unilateral MCR were evaluated prospectively. The fellow eyes of the patients were taken as the control group. A dry eye assessment questionnaire, Schirmer testing, tear film break-up time, fluorescein stain, Rose-Bengal stain, and conjunctival impression cytology were used to assess the tear film functions and ocular surface changes in the operated and non-operated eyes. There was no statistically significant difference in the tear function tests and goblet cell densities between the operated and non-operated eyes. The results indicate that an MCR procedure has no apparent effect on tear function tests and goblet cell density in patients with normal preoperative tear function.

  15. Proptose ocular como manifestação clínica de tumores malignos extra-orbitários: estudo pela tomografia computadorizada

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    Baptista Ana Célia

    2003-01-01

    Full Text Available Doenças sistêmicas, doenças orbitárias primárias e lesões extra-orbitárias com extensão secundária para a órbita podem causar proptose ocular. Foram estudados, por tomografia computadorizada, 11 pacientes com proptose ocular causada por tumores malignos extra-orbitários, sem qualquer tratamento prévio do tumor. Houve predomínio de neoplasias não-epiteliais (82%, tendo sido três rabdomiossarcomas (27% e três linfomas não-Hodgkin (27%. Outros sarcomas estiveram presentes em dois casos (18%, seguidos por linfoma de Burkitt (9%, carcinoma epidermóide (9% e carcinoma pouco diferenciado (9%. Nove tumores (82% tiveram origem nas cavidades sinonasais, a maioria (cinco casos com origem no seio etmoidal. Proptose ocular foi a única alteração oftálmica em quatro casos (36%, e um paciente teve proptose ocular bilateral como único sinal da doença. Dezessete órbitas foram acometidas pelos 11 tumores, já que seis pacientes tiveram comprometimento orbitário tumoral bilateral. Os tumores se estenderam às órbitas preferencialmente através da parede óssea orbitária (16 órbitas; 94%. Das 17 órbitas comprometidas, a maioria (59% teve todos os compartimentos lesados. Em 16 órbitas o tumor apresentou situação extraconal. À tomografia computadorizada, proptose ocular esteve presente em 15 das 17 órbitas (88%, tendo sido bilateral em quatro casos (oito órbitas. Houve predomínio de proptose ocular grau 2 à tomografia computadorizada (sete pacientes; 47%. Um total de 44 regiões crânio-faciais foi comprometido, além da órbita e do sítio de origem da neoplasia, indicando a grande extensão loco-regional desses tumores no momento do diagnóstico.

  16. Ocular correction effects on EMG activity of stomatognathic muscles in children with functional mandibular lateral- deviation: a case control study.

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    Monaco, A; Cattaneo, R; Spadaro, A; D'Andrea, P; Marzo, G; Gatto, R

    2006-06-01

    This study was conducted in order to determine the ocular correction effects on electromyography activity of anterior temporal, masseter, sternocleidomastoid and anterior digastric muscles in children with functional mandibular lateral-deviation. This study was performed on 32 subjects, aged between 8 and 12 years with functional lateral deviation of mandible and oculo-extrinsic muscular tone disorders. After complete ophthalmologic evaluation and ocular correction prescription, the children were randomly divided into two groups: study and control. In the study group (16 subjects) EMG activity at rest was recorded in the following conditions: with eyes closed; with eyes open; with ocular correction modified through electromyographic control. In the control group (16 subjects) EMG activity at rest was recorded in the following conditions: with eyes closed; with eyes open; with conventional ocular correction. Data were acquired in 15-seconds trial using a SEMG K7, while the subjects maintained rest dental position. Both groups presented a significative correlation between value of lateral-deviation and the degree of ocular-extrinsic muscular tone disorders (r=0.69). In addition, a significant statistical increase of EMG activity at rest with eyes open in both groups was observed in the anterior temporal left and right. A significant decrease of EMG activity with open eyes was observed only with ocular correction upon electromyographic control (study group). The findings, expressed as Symmetry Index, showed a significant increase of muscles imbalance right/left with conventional methods of ocular correction (p corrective lenses, could have an important consequence in clinical diagnostic and therapeutic behaviour because anterior temporal muscles are important in postural position of the mandible. Instead EMG corrective lenses could improve tonus and balance of stomatognathic muscles and, therefore, support the functionality of orthodontic treatment. Moreover, the data

  17. The origin of ocular microtremor in man.

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    Spauschus, A; Marsden, J; Halliday, D M; Rosenberg, J R; Brown, P

    1999-06-01

    A novel technique for the study of human eye movements was used to investigate the frequency components of ocular drift and microtremor in both eyes simultaneously. The tangential components of horizontal eye accelerations were recorded in seven healthy subjects using light-weight accelerometers mounted on scleral contact lenses during smooth pursuit movements, vestibulo-ocular reflexes and eccentric gaze with and without fixation. Spectral peaks were observed at low (up to 25 Hz) and high (60-90 Hz) frequencies. A multivariate analysis based on partial coherence analysis was used to correct for head movement. After correction, the signals were found to be coherent between the eyes over both low- and high-frequency ranges, irrespective of task, convergence or fixation. It is concluded that the frequency content of ocular drift and microtremor reflects the patterning of low-level drives to the extra-ocular muscle motor units.

  18. Bilateral enlargement of the orbital muscles: first manifestation of renal adenocarcinoma; Espessamento da musculatura extrinseca orbitaria bilateralmente: manifestacao primaria de adenocarcinoma renal

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    Wolosker, Angela M. Borri; Bekhor, Daniel [Universidade Federal de Sao Paulo (UNIFESP), SP (Brazil). Escola Paulista de Medicina. Dept. de Diagnostico por Imagem; Goes, Paulo [Universidade Federal de Sao Paulo (UNIFESP), SP (Brazil). Escola Paulista de Medicina. Dept. de Oftalmologia; Attie, Greicie Cristina Gerra [Universidade Federal de Sao Paulo (UNIFESP), SP (Brazil). Escola Paulista de Medicina. Dept. de Patologia

    2000-06-01

    The authors present an unusual case of a patient with orbital metastases from renal carcinoma involving the extra ocular muscles bilaterally. The importance of computed tomography for the differential diagnosis with other orbital lesions is emphasized. (author)

  19. Estudo prospectivo comparativo de duas técnicas cirúrgicas de extração extra-capsular planejada de catarata com implante de lente intra-ocular: incisão limbar e incisão escleral tunelizada Prospective comparative study of two techniques of planned extracapsular cataract extraction: limbal incision and scleral tunnel incision

    Directory of Open Access Journals (Sweden)

    Lincoln Lemes Freitas

    2001-06-01

    Full Text Available Introdução: A catarata é responsável por 50% da cegueira no mundo, com um número estimado de 15 milhões de casos que necessitariam cirurgia. Diferentes técnicas para a extração extra-capsular da catarata com implante de lente intra-ocular foram propostas. Objetivo: Comparar as técnicas para extração extra-capsular de catarata com implante de lente intra-ocular utilizando incisão limbar e incisão escleral tunelizada. Métodos: Foram avaliados, prospectivamente, 59 olhos de 54 pacientes com acompanhamento pós-operatório de 6 meses. Aleatoriamente, os pacientes foram divididos em dois grupos. No Grupo I (n=30, a técnica realizada foi a de extração extra-capsular com implante de lente intra-ocular com incisão limbar e no Grupo II (n=29, com incisão tunelizada. Foram avaliadas as medidas da acuidade visual corrigida, inflamação intra-ocular (células e "flare", tempo de cirurgia, microscopia especular, astigmatismo ceratométrico induzido e paquimetria. Resultados: O tempo de cirurgia, a perda de células endoteliais e o astigmatismo ceratométrico induzido foram estatisticamente maiores no Grupo I que no Grupo II. Não houve diferença estatisticamente significante entre os grupos I e II quanto à acuidade visual, a quantidade de células na câmara anterior, a quantidade de "flare" na câmara anterior e paquimetria. Conclusão: A técnica para extração extra-capsular de catarata com incisão tunelizada apresentou vantagens quanto ao tempo de cirurgia, perda de células endoteliais e astigmatismo induzido em relação à técnica com incisão limbar. Os passos utilizados nessa técnica visam facilitar a extração da catarata, além de treinar o cirurgião para uma transição mais segura para facoemulsificação, sem aumentar o custo da cirurgia.Purpose: Cataract is the main cause of blindness throughout the world, affecting more than 15 million people worldwide. There are different techniques for extracapsular cataract

  20. Ocular Hypertension

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    ... Español Eye Health / Eye Health A-Z Ocular Hypertension Sections What Is Ocular Hypertension? Ocular Hypertension Causes ... Hypertension Diagnosis Ocular Hypertension Treatment What Is Ocular Hypertension? Written By: Kierstan Boyd Reviewed By: J Kevin ...

  1. 355 Ocular Muscles Myopathy Associated with Autoimmune Thyroiditis. Case Reports

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    Vargas-Camaño, Eugenia; Castrejon-Vázquez, Isabel; Plazola-Hernández, Sara I.; Moguel-Ancheita, Silvia

    2012-01-01

    Background Thyroid-associated orbitopathy is commonly associated with Graves' disease with lid retraction, exophthalmos, and periorbital swelling, but rarely with autoimmune thyroiditis or euthyroid state. We reviewed 3 cases from our hospital whose antibodies to anti-receptor of TSH were normal. Methods Case 1: 60 year-old non-diabetic woman with bilateral glaucoma in treatment, recurrent media otitis and euthyroidism, acute onset of painless diplopia, and lid ptosis in the left eye. MRI of orbit showed increased size of the III right cranial pair and high levels of thyroid autoantibodies (Tab) anti-tiroglobulin (ATG) 115.1, anti-thyroid peroxidase (ATPO) 1751 U/mL. She started oral deflazacort 30 mg each 3 days. Sixty days later, complete remission of eye symptoms correlated with lower auto-antibodies level (ATG 19 ATPO 117). Case 2: 10 year-old girl. At age 8, she had diplopia, lid ptosis and limitations of upper gaze in the left eye. The neurological study discarded ocular myasthenia; with thyroid goitier, and hypothyrodism, she started oral levothyroxin. At age 10 with normal IRM Botulinic toxin was injected, without change. High levels of Tab were found, ATG 2723, ATPO 10.7. She started oral deflazacort 30 mg each 3 days, azathioprin 100 mg, daily. Actually, Tab levels are almost normal, but she remains with ocular alterations. Case 3: 56 year-old woman, Grave´s disease with exophtalmos in 1990, treated with I131 and immunosupression, with good outcome; obesity, hypertension and bilateral glaucoma in treatment. She suddenly presented diplopia and IV pair paresia of the right eye. A year later, ATb were found slightly elevated, ATG 100 years ATPO 227; despite prednisone 50 mg, each 3 days and azathioprin 150 mg/daily treatment, a surgical procedure was required for relieve the ocular symptoms. Results We found only 3 cases previously reported with this type of eye thyroid disease. Is important to note that awareness of this atypical form of orbitopathy

  2. Extra-cellular matrix proteins induce matrix metalloproteinase-1 (MMP-1 activity and increase airway smooth muscle contraction in asthma.

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    Natasha K Rogers

    Full Text Available Airway remodelling describes the histopathological changes leading to fixed airway obstruction in patients with asthma and includes extra-cellular matrix (ECM deposition. Matrix metalloproteinase-1 (MMP-1 is present in remodelled airways but its relationship with ECM proteins and the resulting functional consequences are unknown. We used airway smooth muscle cells (ASM and bronchial biopsies from control donors and patients with asthma to examine the regulation of MMP-1 by ECM in ASM cells and the effect of MMP-1 on ASM contraction. Collagen-I and tenascin-C induced MMP-1 protein expression, which for tenascin-C, was greater in asthma derived ASM cells. Tenascin-C induced MMP-1 expression was dependent on ERK1/2, JNK and p38 MAPK activation and attenuated by function blocking antibodies against the β1 and β3 integrin subunits. Tenascin-C and MMP-1 were not expressed in normal airways but co-localised in the ASM bundles and reticular basement membrane of patients with asthma. Further, ECM from asthma derived ASM cells stimulated MMP-1 expression to a greater degree than ECM from normal ASM. Bradykinin induced contraction of ASM cells seeded in 3D collagen gels was reduced by the MMP inhibitor ilomastat and by siRNA knockdown of MMP-1. In summary, the induction of MMP-1 in ASM cells by tenascin-C occurs in part via integrin mediated MAPK signalling. MMP-1 and tenascin-C are co-localised in the smooth muscle bundles of patients with asthma where this interaction may contribute to enhanced airway contraction. Our findings suggest that ECM changes in airway remodelling via MMP-1 could contribute to an environment promoting greater airway narrowing in response to broncho-constrictor stimuli and worsening asthma symptoms.

  3. Oxidative phosphorylation in human muscle in patients with ocular myopathy and after general anaesthesia

    NARCIS (Netherlands)

    H.R. Scholte (Hans); E. Agsteribbe (E.); H.F.M. Busch (Herman); T.U. Hoogenraad (T.); F.G.I. Jennekens (Frans G.); B. van Linge (Bert); I.E.M. Luyt-Houwen (I. E M); J.D. Ross (John); M.H.J. Ruiters (M. H J); M.H.M. Verduin (M. H M)

    1990-01-01

    markdownabstractAbstract The fuel preference of human muscle mitochondria has been given. Substrates which are oxidized with low velocity cannot be used to detect defects in oxidative phosphorylation. After general anaesthesia, the oxygen uptake with the different substrates is much lower than aft

  4. Ocular Melanoma

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    ... Español Eye Health / Eye Health A-Z Ocular Melanoma Sections What is Ocular Melanoma? Ocular Melanoma Causes ... Melanoma Diagnosis Ocular Melanoma Treatment What is Ocular Melanoma? Leer en Español: ¿Qué Es el Melanoma Ocular? ...

  5. Inferior oblique muscle paresis as a sign of myasthenia gravis.

    Science.gov (United States)

    Almog, Yehoshua; Ben-David, Merav; Nemet, Arie Y

    2016-03-01

    Myasthenia gravis may affect any of the six extra-ocular muscles, masquerading as any type of ocular motor pathology. The frequency of involvement of each muscle is not well established in the medical literature. This study was designed to determine whether a specific muscle or combination of muscles tends to be predominantly affected. This retrospective review included 30 patients with a clinical diagnosis of myasthenia gravis who had extra-ocular muscle involvement with diplopia at presentation. The diagnosis was confirmed by at least one of the following tests: Tensilon test, acetylcholine receptor antibodies, thymoma on chest CT scan, or suggestive electromyography. Frequency of involvement of each muscle in this cohort was inferior oblique 19 (63.3%), lateral rectus nine (30%), superior rectus four (13.3%), inferior rectus six (20%), medial rectus four (13.3%), and superior oblique three (10%). The inferior oblique was involved more often than any other muscle (pmyasthenia gravis can be difficult, because the disease may mimic every pupil-sparing pattern of ocular misalignment. In addition diplopia caused by paresis of the inferior oblique muscle is rarely encountered (other than as a part of oculomotor nerve palsy). Hence, when a patient presents with vertical diplopia resulting from an isolated inferior oblique palsy, myasthenic etiology should be highly suspected.

  6. Ocular neuropathy in peripheral neuropathies.

    Science.gov (United States)

    Evliyaoglu, Ferhat; Karadag, Remzi; Burakgazi, Ahmet Z

    2012-11-01

    Ocular movements and coordination require complex and integrated functions of somatic and autonomic nervous systems. Neurological disorders affecting these nervous systems may cause ocular dysfunction involving extraocular muscles and pupils. In this article, the prevalence, clinical presentations, and management of ocular neuropathy related to certain peripheral neuropathies, including diabetic neuropathy, Guillain-Barré syndrome (GBS), chronic inflammatory neuropathies, human immunodeficiency virus (HIV)-associated neuropathy, and hereditary neuropathies, are examined in detail. Copyright © 2012 Wiley Periodicals, Inc.

  7. Autologous grafting of extraocular muscles: experimental study in rabbits Transplante autólogo de musculatura ocular extrínseca: estudo experimental em coelhos

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    Jorge Meireles-Teixeira

    2005-06-01

    Full Text Available PURPOSE: To evaluate the feasibility of autologous extraocular muscle grafting as a type of muscle expansion surgery. METHODS: The left superior rectus muscle of twenty-nine rabbits was resected and this fragment was attached to the endpoint of the respective right superior rectus (test group. Thereafter, the superior rectus of the left eye was reattached to the sclera (control group. Both groups were examined during different postoperative periods in order to assess their outcomes. RESULTS: The presence of hyperemia was slightly more frequent in the grafted group. Secretion and muscle atrophy were negligible in both groups. Fibrosis was greater in grafted animals. These muscles were weaker than the control muscles, although the force required to split muscular parts was always greater than the physiological one. CONCLUSIONS: This surgical technique was reliable and useful if one intends to achieve muscle expansion without the intrinsic risks of dealing with heterologous/artificial materials.OBJETIVO: Avaliar a viabilidade do uso de segmentos de músculos oculares extrínsecos como expansores de tendões musculares. MÉTODOS: Vinte e nove coelhos tiveram seu músculo reto superior esquerdo ressecado e o fragmento de cada um foi transplantado para o reto superior contralateral (grupo-teste. Então, o reto superior esquerdo foi reinserido na esclera (grupo-controle. Os animais foram então examinados em diversos períodos pós-operatórios, até os seus sacrifícios, para que se avaliasse o desenrolar dessa técnica cirúrgica. RESULTADOS: A hiperemia foi maior entre os testes. A secreção e a atrofia muscular foram mínimas nos dois grupos. Houve maior presença de fibrose no grupo-teste, mas não tão expressiva a ponto de inviabilizar os efeitos da cirurgia. Esses músculos também se romperam mais facilmente do que os do grupo-controle, porém, a força de rompimento foi sempre bem maior do que aquela presente numa contração muscular normal

  8. Clinical interest of postural and vestibulo-ocular reflex changes induced by cervical muscles and skull vibration in compensated unilateral vestibular lesion patients.

    Science.gov (United States)

    Dumas, Georges; Lion, Alexis; Gauchard, Gérome C; Herpin, Guillaume; Magnusson, Måns; Perrin, Philippe P

    2013-01-01

    Skull vibration induces nystagmus in unilateral vestibular lesion (UVL) patients. Vibration of skull, posterior cervical muscles or inferior limb muscles alters posture in recent UVL patients. This study aimed to investigate the postural effect of vibration in chronic compensated UVL patients. Vibration was applied successively to vertex, each mastoid, each side of posterior cervical muscles and of triceps surae in 12 UVL patients and 9 healthy subjects. Eye movements were recorded with videonystagmography. Postural control was evaluated in eyes open (EO) and eyes closed (EC) conditions. Sway area, sway path, anteroposterior and medio-lateral sways were recorded.A vibration induced nystagmus (VIN) beating toward the healthy side was obtained for each UVL patient during mastoid vibration. In EO, only sway path was higher in UVL group during vibration of mastoids and posterior cervical muscles.The EO postural impairments of UVL patients could be related to the eye movements or VIN, leading to visual perturbations, or to a proprioceptive error signal, providing an erroneous representation of head position. The vibration-induced sway was too small to be clinically useful. Vestibulo-ocular reflex observed with videonystagmography during mastoid vibration seems more relevant to reveal chronic UVL than vestibulo-spinal reflex observed with posturography.

  9. Ocular myasthenia gravis: A review

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    Akshay Gopinathan Nair

    2014-01-01

    Full Text Available Myasthenia gravis (MG is a disease that affects the neuro-muscular junction resulting in classical symptoms of variable muscle weakness and fatigability. It is called the great masquerader owing to its varied clinical presentations. Very often, a patient of MG may present to the ophthalmologist given that a large proportion of patients with systemic myasthenia have ocular involvement either at presentation or during the later course of the disease. The treatment of ocular MG involves both the neurologist and ophthalmologist. Thus, the aim of this review was to highlight the current diagnosis, investigations, and treatment of ocular MG.

  10. Ocular neuromyotonia after radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Lessell, S.; Lessell, I.M.; Rizzo, J.F. III

    1986-12-15

    Ocular neuromyotonia is a paroxysmal monocular deviation that results from spasm of eye muscles secondary to spontaneous discharges from third, fourth, or sixth nerve axons. We observed this rare disorder in four patients who had been treated with radiation for tumors in the region of the sella turcica and cavernous sinus. Based on these cases and four others identified in the literature it would appear that radiation predisposes to a cranial neuropathy in which ocular neuromyotonia may be the major manifestation. Radiation appears to be the most common cause of ocular neuromyotonia.

  11. Ocular Sarcoidosis

    Science.gov (United States)

    Pasadhika, Sirichai; Rosenbaum, James T

    2015-01-01

    Sarcoidosis is one of the leading causes of inflammatory eye disease. Ocular sarcoidosis can involve any part of the eye and its adnexal tissues, and may cause uveitis, episcleritis/scleritis, eyelid abnormalities, conjunctival granuloma, optic neuropathy, lacrimal gland enlargement and orbital inflammation. Glaucoma and cataract can be complications from inflammation itself or adverse effects from therapy. Ophthalmic manifestations can be isolated, or associated with other organ involvement. Patients with ocular sarcoidosis can present with a wide range of clinical presentations and severity. Multi-disciplinary approaches are required to achieve the best treatment outcomes for both ocular and systemic manifestations. PMID:26593141

  12. Traumatismos oculares Ocular traumas

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    Gelen Welch Ruiz

    2007-12-01

    Full Text Available Se realizó un estudio descriptivo de tipo retrospectivo longitudinal cuyo universo estuvo constituido por 72 ojos de 72 pacientes con traumatismos oculares mecánicos que fueron hospitalizados en el Hospital Militar Central “Dr. Carlos J. Finlay” desde enero de 1999 hasta enero de 2005. Para el análisis estadístico de la información se utilizó el programa automatizado SPSS versión 11.5 en el cual también se conformó la base de datos y se realizaron los cálculos de acuerdo con el tipo de variable analizada. Se utilizaron medidas de resumen, tendencia central y asociación estadística con un nivel de significación de p A retrospective longitudinal and descriptive study was carried out in 72 eyes from 72 patients with mechanical occular traumas, who had been hospitalized in “Dr. Carlos J. Finlay” Military Hospital from December 1999 to January 2005. For the statistical data analysis, an automated program (SPSS 11.5 version was used to create the database and estimations were made according to the variable types. Summary measures, central tendency measures and statistical association with significance level equal to p < 0.05 were employed. Males prevailed (95.8%, the average age was 30.26 years with a minimum rate of 17 years and maximum rate of 82 years. The most frequent mechanisms of trauma were aggressions (23. 6% and injures from secondary projectiles (13.9%. The anterior segment traumas were more frequent (61, 1% than posterior segment traumas (6.94%. Both segments of the eyeball were affected in 39, 1% of eyes which evinced the worst visual acuity. The most common associated injures were hyphema (54, 2% and vitreous hemorrhage (16.6%. Closed trauma (contusions were more common and most of the eyes had better final visual acuity (45, 2% with vision range of 0.6-1.0 and 26.2% with vision range of 0.59-0.1. On the other hand, eyes affected by open trauma (simple wound, contusion-wound, wound with intraocular foreign body and

  13. Ocular rosacea

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    Đaković Zorana

    2004-01-01

    Full Text Available Five cases of ocular rosacea (one male and four females are reported in this paper. Two of the patients were with keratoconjunctivitis sicca, one with conjunctivitis chronica and blepharitis, one with conjunctivitis chronica and meibomitis, and one with reccurent corneal erosions with meibomitis and chordeloum. In four patients ocular symptoms preceded the occurence of skin lesions. The treatment with oral tetracyclines significantly improved the state of ocular rosacea in four patients, while in one case the changes of the anterior eye segment progressed in more severe state of ulcerative keratitis. It is considered that in almost 20% of the patients with rosacea ocular lesions may precede the skin changes, representing a diagnostic problem. Thus, in those cases multidisciplinary approach is suggested. Such approach is particularly important because of the decrease of morbidity and the prevention of the onset of the eye complications such as drastic worsening of visual acuity, i.e., the blindness.

  14. Pseudohypoparathyroidism: a series of three cases and an unusual presentation of ocular tetany.

    Science.gov (United States)

    Sunder, R A; Singh, M

    2006-04-01

    Pseudohypoparathyroidism is a heterogeneous group of disorders characterised by hypocalcaemia, hyperphosphataemia, increased serum parathormone and insensitivity to the biological activity of parathormone. These patients may present for incidental surgery, procedures related to kidney stones, cataract removals and renal transplants. No particular anaesthetic agent or technique is indicated except that respiratory alkalosis should be avoided as it may further decrease ionised calcium levels and thereby precipitate tetany. In this report, we present the peri-operative management of three patients with this rare condition and describe an unusual presentation of hypocalcaemic extra-ocular muscle spasm.

  15. Ocular toxocariasis.

    Science.gov (United States)

    Arevalo, J Fernando; Espinoza, Juan V; Arevalo, Fernando A

    2013-01-01

    Ocular toxocariasis is an uncommon worldwide parasitic infection that affects mostly children and is found in both rural and metropolitan areas. In many parts of the world, parasitic infections of the eye are a major cause of blindness. The diagnosis of toxocariasis is essentially clinical, based on the lesion morphology and supportive laboratory data such as serum enzyme-linked immunosorbent assay (ELISA) titers and ELISA Toxocara titers on aqueous humor; other diagnostic methods are imaging studies including optical coherence tomography, fluorescein angiography, computed tomography, and ocular ultrasound. Treatment is directed at complications arising from intraocular inflammation and vitreous membrane traction. Early vitrectomy may be of value both diagnostically and therapeutically.

  16. Ocular Neuromyotonia Associated with Chronic Inflammatory Demyelinating Polyneuropathy.

    Science.gov (United States)

    Kung, Nathan H; Bucelli, Robert C; McClelland, Collin M; Van Stavern, Gregory P

    2015-10-01

    Ocular neuromyotonia (ONM) is a neuro-ophthalmic disorder characterized by episodic diplopia caused by contraction of one or more ocular muscles due to spontaneous excitation of the respective ocular motor nerve. We report a patient whose ocular neuromyotonia arose in the setting of a subacute demyelinating polyneuropathy consistent with chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently resolved following the initiation of intravenous immunoglobulin (IVIg) for her neuropathy. Our patient provides additional evidence towards the role of demyelination and ephaptic neurotransmission in ocular neuromyotonia and also represents the first reported case of ocular neuromyotonia associated with a systemic neurological condition.

  17. Main Ocular Manifestations in Rheumatoid Arthritis

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    Sandra Saray Quignon Santana

    2009-12-01

    Full Text Available Rheumatoid arthritis is considered an autoimmune disease in which articular and extra articular manifestations are produced and contribute to alter the functional capacity of the individual. This study consists on performing a bibliographical review showing the main ocular manifestations in patients with rheumatoid arthritis. It is our purpose to give you our experiences to the students as well as the internal medicine, ophthalmology and rheumatologist residents about this topic. The ophthalmological consultation of sick patients contributes to the prevention of ocular illnesses which are characteristic of the base disease and improve the ocular health.

  18. Ocular Vestibular Evoked Myogenic Potentials

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    Felipe, Lilian

    2014-01-01

    Full Text Available Introduction Diagnostic testing of the vestibular system is an essential component of treating patients with balance dysfunction. Until recently, testing methods primarily evaluated the integrity of the horizontal semicircular canal, which is only a portion of the vestibular system. Recent advances in technology have afforded clinicians the ability to assess otolith function through vestibular evoked myogenic potential (VEMP testing. VEMP testing from the inferior extraocular muscles of the eye has been the subject of interest of recent research. Objective To summarize recent developments in ocular VEMP testing. Results Recent studies suggest that the ocular VEMP is produced by otolith afferents in the superior division of the vestibular nerve. The ocular VEMP is a short latency potential, composed of extraocular myogenic responses activated by sound stimulation and registered by surface electromyography via ipsilateral otolithic and contralateral extraocular muscle activation. The inferior oblique muscle is the most superficial of the six extraocular muscles responsible for eye movement. Therefore, measurement of ocular VEMPs can be performed easily by using surface electrodes on the skin below the eyes contralateral to the stimulated side. Conclusion This new variation of the VEMP procedure may supplement conventional testing in difficult to test populations. It may also be possible to use this technique to evaluate previously inaccessible information on the vestibular system.

  19. Ocular dirofilariasis

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    Nath Reema

    2010-01-01

    Full Text Available Dirofilaria is a parasite of domestic and wild animals that can infect humans accidentally. It is being reported in increasing numbers from Mediterranean countries like Italy. In India this infection is occasionally being reported. We report three cases of ocular dirofilariasis from the state of Assam presenting as periorbital and subconjunctival cysts. The parasites were identified as Dirofilaria repens. The purpose of this article is to take note of this emerging zoonosis in Assam; also to review literature in the cases reported.

  20. Ocular microtremor: a tool for measuring depth of anaesthesia?

    Science.gov (United States)

    Bojanic, S; Simpson, T; Bolger, C

    2001-04-01

    Ocular microtremor (OMT) is a fine high frequency tremor of the eyes caused by extra-ocular muscle activity stimulated by impulses emanating in the brain stem. Several studies have shown that the frequency of this tremor is reduced in patients whose consciousness is reduced by anaesthesia or head injury. Therefore, OMT may possibly be used to determine depth of anaesthesia. Twenty-two unpre-medicated subjects undergoing surgery with general anaesthesia were studied. OMT activity was measured at admission using the open eye piezoelectric strain gauge technique. Anaesthesia was induced with propofol using a target controlled infusion delivery system (Diprifusor). OMT activity was then recorded at predicted plasma propofol concentrations of 1, 2, 3 and 5 microg ml(-1). The patient's level of consciousness (response to command or stimulation) was assessed after each OMT measurement. OMT activity was reduced progressively at predicted plasma concentrations of propofol of I and 2 microg ml(-1) and then plateaued between 3 and 5 microg ml(-1). There was a significant difference between the last awake OMT recording and the first recording at loss of consciousness (P < 0.001). OMT recording holds promise as a practical indicator of the depth of anaesthesia.

  1. Cisticercosis ocular

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    Danaides Arencibia González

    Full Text Available La cisticercosis establece un grupo de enfermedades zoonóticas parasitarias; cuando se aloja en el ojo y sus anexos producen una cisticercosis ocular y periocular. Constituye una de las causas de uveítis ocular y pérdida importante de la visión. El diagnóstico clínico se realiza mediante la observación directa del parásito, cuando existen opacidades de los medios, el ultrasonido se emplea como medio diagnóstico útil. Los anti helmintos asociados a esteroides forman parte de su terapéutica, sumado al tratamiento definitivo de la extracción del parásito, en este tipo de afección mediante vitrectomía vía pars plana. Se presenta un caso portador de esta condición, se describen las características más importantes del cuadro clínico, diagnóstico, manejo y curso evolutivo-terapéutico.

  2. Isolated abscess in superior rectus muscle in a child

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    Sushank Ashok Bhalerao

    2015-01-01

    Full Text Available Pyomyositis is a primary bacterial infection of striated muscles nearly always caused by Staphylococcus aureus. Development of the intramuscular abscess involving the extra-ocular muscles (EOMs remains an extremely rare process. We herein present a case of isolated EOM pyomyositis involving superior rectus muscle in a 2-year male child who was referred with complaints of swelling in left eye (LE and inability to open LE since last 1-month. Orbital computed tomography (CT scan showed a well-defined, hypo-dense, peripheral rim-enhancing lesion in relation to left superior rectus muscle suggestive of left superior rectus abscess. The abscess was drained through skin approach. We concluded that pyomyositis of EOM should be considered in any patient presenting with acute onset of orbital inflammation and characteristic CT or magnetic resonance imaging features. Management consists of incision and drainage coupled with antibiotic therapy.

  3. Miasis ocular por Oestrus ovis

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    María Beltrán F

    2006-01-01

    Full Text Available Se presentan tres casos de miasis ocular (dos adultos y un niñoprocedentes de zonas ganaderas de la provincia de Huaura,departamento de Lima,que acudieron al Hospital Regional de Huacho por presentar el ojo rojo,fotofobia, edema palpebral y sensación de cuerpo extraño;se extrajeron larvas adheridas al canto interno del ojo,las cuales se recibieron en el Instituto Nacional de Salud y fueron identificadas como Oestrus ovis .

  4. Laminin beta 2 chain and adhalin deficiency in the skeletal muscle of Walker-Warburg syndrome (cerebro-ocular dysplasia-muscular dystrophy)

    DEFF Research Database (Denmark)

    Wewer, U M; Durkin, M E; Zhang, X

    1995-01-01

    Muscular dystrophy may be caused by disturbances in a number of muscle proteins that appear to be part of a chain of interacting molecules that includes cytoskeletal, cell membrane, and basement membrane components. We found that the skeletal muscle cells in two cases of Walker-Warburg syndrome w...

  5. Ocular manifestations of candidemia

    NARCIS (Netherlands)

    Oude Lashof, A.M.L.; Rothova, A.; Sobel, J.D.; Ruhnke, M.; Pappas, P.G.; Viscoli, C.; Schlamm, H.T.; Oborska, I.T.; Rex, J.H.; Kullberg, B.J.

    2011-01-01

    BACKGROUND: Ocular candidiasis is a major complication of candidemia. The incidence, risk factors, and outcome of eye involvement during candidemia are largely unknown. We prospectively studied the ocular manifestations of candidemia in a large, worldwide, randomized multicenter trial that compared

  6. Microsurgical anatomy of the ocular motor nerves.

    Science.gov (United States)

    Zhang, Yi; Liu, Hao; Liu, En-Zhong; Lin, You-Zhi; Zhao, Shi-Guang; Jing, Guo-Hua

    2010-08-01

    This study was designed to provide anatomic data to help surgeons avoid damage to the ocular motor nerves during intraorbital operations. The microsurgical anatomy of the ocular motor nerves was studied in 50 adult cadaveric heads (100 orbits). Dissections were performed with a microscope. The nerves were exposed and the neural and muscular relationships of each portion of the nerve were examined and measured. The superior division of the oculomotor nerve coursed between the optic nerve and the superior rectus muscle after it left the annular tendon, and its branches entered into the superior rectus muscle and levator muscle. A mean of five fibers (range 3-7) innervated the superior rectus muscle, and a mean of one fiber (range 1-2) followed a medial direction (84%) or went straight through the superior rectus muscle (16%). The inferior division of the oculomotor nerve branched into the medial rectus, inferior rectus and inferior oblique muscles. The trochlear nerve ended on the orbital side of the posterior one-third of the superior oblique muscle in 76 specimens. The abducens nerve ended on the posterior one-third of the lateral rectus muscle in 86 specimens. If the belly of the lateral rectus muscle was divided into three superior-inferior parts, the nerve commonly entered into the middle one-third in 74 specimens. Based on the observed data, microanatomical relationships of the orbital contents were revised.

  7. Main Ocular Manifestations in Rheumatoid Arthritis Principales manifestaciones oculares en la artritis reumatoide

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    Osbel Alfonso Sánchez

    2009-12-01

    Full Text Available Rheumatoid arthritis is considered an autoimmune disease in which articular and extra articular manifestations are produced and contribute to alter the functional capacity of the individual. This study consists on performing a bibliographical review showing the main ocular manifestations in patients with rheumatoid arthritis. It is our purpose to give you our experiences to the students as well as the internal medicine, ophthalmology and rheumatologist residents about this topic. The ophthalmological consultation of sick patients contributes to the prevention of ocular illnesses which are characteristic of the base disease and improve the ocular health.La artritis reumatoide se considera una enfermedad autoinmune, la cual produce manifestaciones articulares y extraarticulares que contribuyen a alterar la capacidad funcional del individuo. En esta revisión se muestran las principales manifestaciones oculares en pacientes con diagnóstico de dicha enfermedad. Se describen experiencias válidas para estudiantes y residentes de medicina interna, oftalmología y reumatología y se realiza la valoración de la interconsulta oftalmológica de los pacientes enfermos en la prevención de afecciones oculares propias de la enfermedad de base y su contribución al mejoramiento de su salud ocular.

  8. Ocular abnormality in myotonic dystrophy.

    Science.gov (United States)

    Ginsberg, J; Hamblet, J; Menefee, M

    1978-08-01

    A 61-year-old white woman with terminal myotonic dystrophy exhibited advanced peripheral and central retinopathy. Retinal lesions were characterized by hyperpigmentation, common, though nonspecific, in myotonic dystrophy. They resemble both heredo (tapetoretinal) and idiopathic involutional degenerations but rarely cause severe visual impairment. Neither the type nor degree of retinopathy appears to correlate with other ocular features or with the stage of the underlying disease. Our histologic observations confirm and extend those previously described. Electron microscopy suggests a primary disorder of mitochondria which may also affect smooth muscle and the myocardium.

  9. Metástase no músculo reto inferior como sinal de apresentação de adenocarcinoma renal: relato de caso Inferior rectus muscle metastasis as a presenting sign of renal cell carcinoma: case report

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    Allan Christian Pieroni Gonçalves

    2006-06-01

    Full Text Available Proptose e diplopia decorrentes de alargamento de músculo extra-ocular representam importante sinal de apresentação de várias afecções da órbita. Embora a causa mais comum de alargamento de músculo extra-ocular seja a orbitopatia distiroidiana, o diagnóstico diferencial destas doenças é extenso. Relatamos neste trabalho o caso de um paciente com história de diplopia e proptose unilateral de três meses que apresentava importante espessamento isolado do músculo reto inferior direito e após investigação clínica, radiológica e biopsia incisional teve o diagnóstico de tumor metastático de células renais para o músculo reto inferior. Há poucos casos relatados de metástases para a musculatura ocular extrínseca sendo assim nosso objetivo relatar um novo caso, revisar a literatura e reforçar a inclusão deste distúrbio no diagnóstico diferencial do espessamento da musculatura extra-ocular.Proptosis and diplopia due to enlargement of extraocular muscles represent important presenting signs of many orbital disorders. Although dysthyroid ophthalmopathy is the most common cause of enlargement of extraocular muscles, the differential diagnosis is extensive. We report a patient with a 3-month history of diplopia and unilateral proptosis and a markedly enlarged inferior rectus muscle on imaging studies. A biopsy of the lesion followed by systemic evaluation established the diagnosis of metastatic renal cell carcinoma. There are few cases of metastatic tumors to the extraocular muscles reported in the literature and thus our objective is to report a new case, review the literature and reiterate the inclusion of this disorder in the differential diagnosis of enlargement of the extraocular muscles.

  10. Human ocular Thelaziasis in Karnataka

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    Prabhakar S Krishnachary

    2014-01-01

    Full Text Available Thelaziasis is an Arthropod-born disease of the eye and adnexa caused by Thelazia callipaeda, a nematode parasite transmitted by drosophilid flies to carnivores and humans. Because of its distribution mainly confined to South Asian countries and Russia, it is commonly known as Oriental Eye worm. It is often under-reported and not been given its due clinical importance. We report first case of human Thelaziasis from Hassan District, Karnataka. Five creamy-white, translucent worms were removed from the conjunctival sac of a 74-year-old male patient. Based on morphological characters, the worms were identified as nematodes belonging to the genus Thelazia and speciation was confirmed by CDC, Atlanta as callipaeda. Rarity of the disease and its ability to cause both extra and intraocular manifestations leading to ocular morbidity is the reason for presenting this case. From the available data, this is the first case report from Karnataka, India.

  11. Sporadic and familial blepharophimosis -ptosis-epicanthus inversus syndrome: FOXL2 mutation screen and MRI study of the superior levator eyelid muscle.

    Science.gov (United States)

    Dollfus, H; Stoetzel, C; Riehm, S; Lahlou Boukoffa, W; Bediard Boulaneb, F; Quillet, R; Abu-Eid, M; Speeg-Schatz, C; Francfort, J J; Flament, J; Veillon, F; Perrin-Schmitt, F

    2003-02-01

    The analysis of the FOXL2 gene (3q23) in a series of two families and two sporadic cases affected with Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome (BPES) is presented. This study detected two novel FOXL2 mutations (missence and nonsens mutations) and confirmed the recurrence of a previously described duplication. Magnetic Resonance Imaging (MRI) of the orbit, in one family, showed absence or hypotrophy of the eyelid superior levator muscle suggesting a possible role of FOXL2 in the development of this extra-ocular muscle.

  12. Thermography in ocular inflammation

    Science.gov (United States)

    Kawali, Ankush A

    2013-01-01

    Background and Objectives: The purpose of this study was to evaluate ocular inflammatory and non-inflammatory conditions using commercially available thermal camera. Materials and Methods: A non-contact thermographic camera (FLIR P 620) was used to take thermal pictures of seven cases of ocular inflammation, two cases of non-inflammatory ocular pathology, and one healthy subject with mild refractive error only. Ocular inflammatory cases included five cases of scleritis, one case of postoperative anterior uveitis, and a case of meibomian gland dysfunction with keratitis (MGD-keratitis). Non-inflammatory conditions included a case of conjunctival benign reactive lymphoid hyperplasia (BRLH) and a case of central serous chorio-retinopathy. Thermal and non-thermal photographs were taken, and using analyzing software, the ocular surface temperature was calculated. Results: Patient with fresh episode of scleritis revealed high temperature. Eyes with MGD-keratitis depicted lower temperature in clinically more affected eye. Conjunctival BRLH showed a cold lesion on thermography at the site of involvement, in contrast to cases of scleritis with similar clinical presentation. Conclusion: Ocular thermal imaging is an underutilized diagnostic tool which can be used to distinguish inflammatory ocular conditions from non-inflammatory conditions. It can also be utilized in the evaluation of tear film in dry eye syndrome. Its applications should be further explored in uveitis and other ocular disorders. Dedicated “ocular thermographic” camera is today's need of the hour. PMID:24347863

  13. Thermography in ocular inflammation

    Directory of Open Access Journals (Sweden)

    Ankush A Kawali

    2013-01-01

    Full Text Available Background and Objectives: The purpose of this study was to evaluate ocular inflammatory and non-inflammatory conditions using commercially available thermal camera. Materials and Methods: A non-contact thermographic camera (FLIR P 620 was used to take thermal pictures of seven cases of ocular inflammation, two cases of non-inflammatory ocular pathology, and one healthy subject with mild refractive error only. Ocular inflammatory cases included five cases of scleritis, one case of postoperative anterior uveitis, and a case of meibomian gland dysfunction with keratitis (MGD-keratitis. Non-inflammatory conditions included a case of conjunctival benign reactive lymphoid hyperplasia (BRLH and a case of central serous chorio-retinopathy. Thermal and non-thermal photographs were taken, and using analyzing software, the ocular surface temperature was calculated. Results: Patient with fresh episode of scleritis revealed high temperature. Eyes with MGD-keratitis depicted lower temperature in clinically more affected eye. Conjunctival BRLH showed a cold lesion on thermography at the site of involvement, in contrast to cases of scleritis with similar clinical presentation. Conclusion: Ocular thermal imaging is an underutilized diagnostic tool which can be used to distinguish inflammatory ocular conditions from non-inflammatory conditions. It can also be utilized in the evaluation of tear film in dry eye syndrome. Its applications should be further explored in uveitis and other ocular disorders. Dedicated "ocular thermographic" camera is today′s need of the hour.

  14. Cluster bomb ocular injuries

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    Ahmad M Mansour

    2012-01-01

    Full Text Available Purpose: To present the visual outcomes and ocular sequelae of victims of cluster bombs. Materials and Methods: This retrospective, multicenter case series of ocular injury due to cluster bombs was conducted for 3 years after the war in South Lebanon (July 2006. Data were gathered from the reports to the Information Management System for Mine Action. Results: There were 308 victims of clusters bombs; 36 individuals were killed, of which 2 received ocular lacerations and; 272 individuals were injured with 18 receiving ocular injury. These 18 surviving individuals were assessed by the authors. Ocular injury occurred in 6.5% (20/308 of cluster bomb victims. Trauma to multiple organs occurred in 12 of 18 cases (67% with ocular injury. Ocular findings included corneal or scleral lacerations (16 eyes, corneal foreign bodies (9 eyes, corneal decompensation (2 eyes, ruptured cataract (6 eyes, and intravitreal foreign bodies (10 eyes. The corneas of one patient had extreme attenuation of the endothelium. Conclusions: Ocular injury occurred in 6.5% of cluster bomb victims and 67% of the patients with ocular injury sustained trauma to multiple organs. Visual morbidity in civilians is an additional reason for a global ban on the use of cluster bombs.

  15. Miopatia ocular descendente Descending ocular myopathy

    Directory of Open Access Journals (Sweden)

    Nunjo Finkel

    1972-06-01

    Full Text Available São relatados 4 casos de miopatia ocular descendente (MOD com história familial levantada em três gerações. Biópsia musculares e eletromiografia em um caso confirmaram o caráter miogênico da doença. A MOD nada mais seria do que uma forma clínica especial de distrofia muscular, de início tardio.Four cases of the so-called descending ocular myopathy with a family history in three generations are reported. In the first case muscular biopsy and electromyographic studies proved the myogenic nature of the process. Descending ocular myopathy seems to be just a clinical form of muscular distrophy of late onset.

  16. Epidemiology of Ocular Toxoplasmosis

    NARCIS (Netherlands)

    Petersen, E.; Kijlstra, A.; Stanford, M.

    2012-01-01

    Retinal infection with Toxoplasma gondii is the most important cause of posterior uveitis, whereby prevalence and incidence of ocular symptoms after infection depend on socio-economic factors and the circulating parasite genotypes. Ocular toxoplasmosis is more common in South America, Central Americ

  17. Epidemiology of Ocular Toxoplasmosis

    NARCIS (Netherlands)

    Petersen, E.; Kijlstra, A.; Stanford, M.

    2012-01-01

    Retinal infection with Toxoplasma gondii is the most important cause of posterior uveitis, whereby prevalence and incidence of ocular symptoms after infection depend on socio-economic factors and the circulating parasite genotypes. Ocular toxoplasmosis is more common in South America, Central Americ

  18. Introduction to Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Rizzo, Thomas G.; /SLAC

    2010-04-29

    Extra dimensions provide a very useful tool in addressing a number of the fundamental problems faced by the Standard Model. The following provides a very basic introduction to this very broad subject area as given at the VIII School of the Gravitational and Mathematical Physics Division of the Mexican Physical Society in December 2009. Some prospects for extra dimensional searches at the 7 TeV LHC with {approx}1 fb{sup -1} of integrated luminosity are provided.

  19. Ocular microtremor in oculomotor palsy.

    Science.gov (United States)

    Bolger, C; Bojanic, S; Sheahan, N F; Coakley, D; Malone, J F

    1999-03-01

    Ocular microtremor (OMT) is a high frequency tremor of the eyes present in all individuals. Recent reports suggest that OMT may be a useful indicator of brainstem function. However, the actual origin of ocular microtremor remains controversial. This study aims to provide evidence that OMT has a neurogenic origin. The OMT activity of five subjects with unilateral oculomotor nerve palsy and one subject with complete unilateral internal and external ophthalmoplegia were recorded from both eyes of each subject using the piezoelectric strain gauge technique, with the normal eye acting as a control. Five parameters of OMT activity were studied in each subject: the peak count, the power of the high frequency peak, the percentage power between 60 and 100 Hz, the percentage power between 70 and 80 Hz, and the 10 dB cut-off point. In the five subjects with oculomotor nerve palsy, the mean peak count in the normal eye was 88.4 Hz (SD+/-16.9) and in the affected eye was 59 Hz (SD+/-8.6), P < 0.0096. There was also a fall in the peak power, the power between 60 and 100 Hz, and the power between 70 and 80 Hz. In subject six, who had complete opthalmoplegia, there was no evidence of OMT activity in the denervated eye. These results suggest that innervation of the extraocular muscles is necessary for normal OMT activity, and OMT therefore has a neurogenic origin.

  20. Congenital Ocular Motor Apraxia

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2007-06-01

    Full Text Available The clinical and neuroradiological findings, and long-term intellectual prognosis in 10 patients (4 boys and 6 girls with congenital ocular motor apraxia (COMA are reviewed by researchers at Tottori University, Yonago, Japan.

  1. Ocular rosacea: a review

    Directory of Open Access Journals (Sweden)

    Ana Carolina Cabreira Vieira

    2012-10-01

    Full Text Available Rosacea is a prevalent chronic cutaneous disorder with variable presentation and severity. Although considered a skin disease, rosacea may evolve the eyes in 58-72% of the patients, causing eyelid and ocular surface inflammation. About one third of the patients develop potentially sight-threatening corneal involvement. Untreated rosacea may cause varying degrees of ocular morbidity. The importance of early diagnosis and adequate treatment cannot be overemphasized. There is not yet a diagnostic test for rosacea. The diagnosis of ocular rosacea relies on observation of clinical features, which can be challenging in up to 90% of patients in whom accompanying roseatic skin changes may be subtle or inexistent. In this review, we describe the pathophysiologic mechanisms proposed in the literature, clinical features, diagnosis and management of ocular rosacea, as well as discuss the need for a diagnostic test for the disease.

  2. Ultrasonography in ocular trauma.

    Science.gov (United States)

    Dastevska-Djosevska, Emilija

    2013-01-01

    Ultrasonography is a non-invasive, simple and effective diagnostic method which enables visualization and evaluation of intraocular injury degree in cloudy eye media. The basic aim of this investigation was to find out the frequency of various types of ocular injuries using ultrasonography and to make an analysis of their frequency in relation to gender and age. This retrospective study included 182 patients hospitalized at the Clinic of Ophthalmology in Skopje due to mechanical eye trauma. The patients underwent ultrasonography on the Alcon Ultrascan Imagining System apparatus and Sonomed EZ Scan AB 5500+. B scan technique was used primarily, while the A scan had a positive and correlative role. Ocular trauma was more present in males (85.2%) compared to females (14.8%). 49.5% of the patients had open, and 50.5% had closed globe injuries. The most represented age group in ocular injuries was the age ranged from 51 to 60 years. There was no significant difference between the type of mechanical injury and the age (Chi-Squares=5.52 p=0.47895025). Ultrasonography showed that the most frequent pathologic result, both in open and closed globe injuries, was vitreous hemorrhage. Ultrasonography has an irreplaceable role in the clinical evaluation and management of ocular trauma. It showed that the most frequent finding in ocular trauma was vitreous haemorrhage, and the male gender was more frequently exposed to ocular trauma.

  3. Cosmology With Extra Dimensions

    CERN Document Server

    Martín, J

    2005-01-01

    We review several properties of models that include extra dimensions, focusing on aspects related to cosmology and particle physics phenomenology. The properties of effective four dimensional inflationary geometry are studied in two distinct frameworks: (i) in Kaluza- Klein (KK) compactifications and (ii) in braneworld scenarios. From numerical simulations we find that inflationary braneworlds are unstable if the scale of inflation is too large in comparison with the stabilization scale of the interbrane distance. The analysis of perturbations confirms the existence of a tachyon associated with the volume modulus of the extra dimensions both in braneworlds and KK compactifications. With the numerical program BRANECODE non- perturbative properties of braneworlds are studied. We fully understand the non-perturbative consequences of this instability. Generic attractors are (i) an increase of the interbrane distance and the formation of a naked singularity, (ii) the brane colli...

  4. SCONUL Research Extra

    OpenAIRE

    John Hall

    2006-01-01

    SCONUL Research Extra is a cooperative access and borrowing scheme for staff and research students in UK and Irish higher education institutions. Under the terms of the scheme, eligible researchers may visit any participating library and register as an external borrower. The scheme is run on behalf of SCONUL, the Society of College, National and University Libraries which represents the directors of the library and information services in all the universities of the United Kingdom and Ireland...

  5. Artefactos en ultrasonido ocular

    Directory of Open Access Journals (Sweden)

    Mariana Mayorquín Ruiz

    2016-07-01

    Full Text Available El ultrasonido ocular es un estudio dependiente del operador. Un buen estudio ecográfico debe tener como base el conocimiento de la anatomía y fisiología normales y de los cambios producidos en diferentes enfermedades, así como los cambios tras una cirugía ocular o trauma. El conocimiento de los fenómenos físicos producidos por el ultrasonido es la base para entender y reconocer la presencia de artefactos en el ultrasonido ocular. Esta revisión tiene como objetivo hacer un recuento de los artefactos que pueden ocasionar confusión al interpretar una imagen ecográfica, así como explicar la base física en la que se basan, reduciendo de esta manera los errores de interpretación y diagnósticos.

  6. Ocular complications of boxing.

    Science.gov (United States)

    Bianco, M; Vaiano, A S; Colella, F; Coccimiglio, F; Moscetti, M; Palmieri, V; Focosi, F; Zeppilli, P; Vinger, P F

    2005-02-01

    To investigate the prevalence of ocular injuries in a large population of boxers over a period of 16 years, in particular, the most severe lesions that may be vision threatening. Clinical records of the medical archive of the Italian Boxing Federation were analysed. A total of 1032 boxers were examined from February 1982 to October 1998. A complete ophthalmological history was available for 956, who formed the study population (a total of 10 697 examinations). The following data were collected: age when started boxing; duration of competitive boxing career (from the date of the first bout); weight category; a thorough ocular history. The following investigations were carried out: measurement of visual acuity and visual fields, anterior segment inspection, applanation tonometry, gonioscopy, and examination of ocular fundus. Eighty age matched healthy subjects, who had never boxed, formed the control group. Of the 956 boxers examined, 428 were amateur (44.8%) and 528 professional (55.2%). The median age at first examination was 23.1 (4.3) years (range 15-36). The prevalence of conjunctival, corneal, lenticular, vitreal, ocular papilla, and retinal alterations in the study population was 40.9% compared with 3.1% in the control group (p< or =0.0001). The prevalence of serious ocular findings (angle, lens, macula, and peripheral retina alterations) was 5.6% in boxers and 3.1% in controls (NS). Boxing does not result in a higher prevalence of severe ocular lesions than in the general population. However, the prevalence of milder lesions (in particular with regard to the conjunctiva and cornea) is noteworthy, justifying the need for adequate ophthalmological surveillance.

  7. Ocular complications of boxing

    Science.gov (United States)

    Bianco, M; Vaiano, A; Colella, F; Coccimiglio, F; Moscetti, M; Palmieri, V; Focosi, F; Zeppilli, P; Vinger, P

    2005-01-01

    Objectives: To investigate the prevalence of ocular injuries in a large population of boxers over a period of 16 years, in particular, the most severe lesions that may be vision threatening. Methods: Clinical records of the medical archive of the Italian Boxing Federation were analysed. A total of 1032 boxers were examined from February 1982 to October 1998. A complete ophthalmological history was available for 956, who formed the study population (a total of 10 697 examinations). The following data were collected: age when started boxing; duration of competitive boxing career (from the date of the first bout); weight category; a thorough ocular history. The following investigations were carried out: measurement of visual acuity and visual fields, anterior segment inspection, applanation tonometry, gonioscopy, and examination of ocular fundus. Eighty age matched healthy subjects, who had never boxed, formed the control group. Results: Of the 956 boxers examined, 428 were amateur (44.8%) and 528 professional (55.2%). The median age at first examination was 23.1 (4.3) years (range 15–36). The prevalence of conjunctival, corneal, lenticular, vitreal, ocular papilla, and retinal alterations in the study population was 40.9% compared with 3.1% in the control group (p⩽0.0001). The prevalence of serious ocular findings (angle, lens, macula, and peripheral retina alterations) was 5.6% in boxers and 3.1% in controls (NS). Conclusions: Boxing does not result in a higher prevalence of severe ocular lesions than in the general population. However, the prevalence of milder lesions (in particular with regard to the conjunctiva and cornea) is noteworthy, justifying the need for adequate ophthalmological surveillance. PMID:15665199

  8. Ocular Surface Reconstruction: Recent Innovations

    OpenAIRE

    Madhavan HN

    2009-01-01

    The ocular surface is exceptionally rich in complexity and functionality. Severe ocular surface disorders/conditions, such as chemical or thermal injuries, Stevens-Johnson syndrome (SJS), ocular cicatricial pemphigoid, neurotrophic keratopathy, chronic limbitis, and severe microbial keratitis cause significant morbidities and even corneal blindness. Hypofunction may be caused by Aniridia, Neurotrophy, Endocrine, Pterygium and Chronic limbitis Approximately 6000 patients are seen in Ocular Sur...

  9. Immunogenetics of ocular inflammatory disease.

    Science.gov (United States)

    Levinson, R D

    2007-02-01

    Ocular inflammatory disease comprises of a diverse group of clinical entities that may result from autoimmune processes, infections, or both. While many individual ocular inflammatory diseases are quite rare, ocular inflammation is one of the more common causes of visual disability, including blindness, in the developed world. Better understanding of ocular inflammatory disease is an important step in designing more sophisticated therapies that may help prevent loss of visual function for these patients.

  10. Ocular involvement of brucellosis.

    Science.gov (United States)

    Bazzazi, Nooshin; Yavarikia, Alireza; Keramat, Fariba

    2013-01-01

    A 29-year-old male diagnosed with brucellosis a week earlier was referred to the ophthalmology clinic with visual complaints. On examination, visual acuity was 20/25, he had conjunctival injection on slit lamp examination. There was also bilateral optic disk swelling plus retinal hyperemia (optic disc hyperemia and vascular tortuosity) and intraretinal hemorrhage on funduscopy. The patient was admitted and treated with cotrimoxazole, rifampin, doxycycline and prednisolone for 2 months. Ocular manifestations subsided gradually within 6 months after treatment. Brucellosis can affect the eye and lead to serious ocular complications. Early diagnosis and prompt treatment should be considered in endemic areas.

  11. Correction of ocular dystopia.

    Science.gov (United States)

    Janecka, I P

    1996-04-01

    The purpose of this study was to examine results with elective surgical correction of enophthalmos. The study was a retrospective assessment in a university-based referral practice. A consecutive sample of 10 patients who developed ocular dystopia following orbital trauma was examined. The main outcome measures were a subjective evaluation by patients and objective measurements of patients' eye position. The intervention was three-dimensional orbital reconstruction with titanium plates. It is concluded that satisfactory correction of enophthalmos and ocular dystopia can be achieved with elective surgery using titanium plates. In addition, intraoperative measurements of eye position in three planes increases the precision of surgery.

  12. Bedside ocular ultrasound.

    Science.gov (United States)

    Roque, Pedro J; Hatch, Nicholas; Barr, Laurel; Wu, Teresa S

    2014-04-01

    Many ocular emergencies are difficult to diagnose in the emergency setting with conventional physical examination tools. Additionally, persistent efforts to re-examine the eye may be deleterious to a patient's overall condition. Ultrasound is an important tool because it affords physicians a rapid, portable, accurate, and dynamic tool for evaluation of a variety of ocular and orbital diseases. The importance of understanding orbital anatomy, with attention to the firm attachment points of the various layers of the eye, cannot be understated. This article describes the relevant eye anatomy, delves into the ultrasound technique, and illustrates a variety of orbital pathologies detectable by bedside ultrasound.

  13. Patología ocular en el ámbito laboral

    OpenAIRE

    Petuya Sires, Teresa

    2013-01-01

    La ergoftalmología que es la sociedad de oftalmología laboral, explicación de sus inicios y estudios recientes.Clasificación de la patología ocular en el ámbito laboral, las alteraciones oculars como hiposfagma, ojo seco y conjuntivitis. Y los traumatismos oculares como causticaciones, contusiones, heridas perforantes o no como erosión corneal y cuerpo extraño y lesiones de párpados.La prevención de esta patología se consigue con la aplicación de las reglas ergonómicas tanto a nivel individua...

  14. Ocular rosacea: a dermatologic perspective.

    Science.gov (United States)

    Webster, Guy; Schaller, Martin

    2013-12-01

    As many as 50% of patients given the diagnosis of cutaneous rosacea also have ocular rosacea. Conservative figures indicate that approximately 10 million patients are affected by ocular rosacea in the United States alone. Despite this prevalence, ocular symptoms of rosacea are often improperly diagnosed, particularly when they occur in the absence of skin involvement.

  15. Ocular manifestations of leptospirosis

    Directory of Open Access Journals (Sweden)

    Rathinam S

    2005-01-01

    Full Text Available Leptospiral uveitis is a common entity in tropical countries. Ocular manifestations are noted in the second phase of illness, but these remain under-diagnosed mainly because of the prolonged symptom-free period that separates the systemic manifestations from detection of ocular manifestations.Varying ophthalmic presentations and the intrinsic nature of different types of uveitis to mimic one another also challenge the accuracy of the diagnosis. Of the individual ocular signs, the combination of acute, non-granulomatous, panuveitis, hypopyon, vasculitis, optic disc edema, membranous vitreous opacities and absence of choroiditis or retinitis have high predictive value for the clinical diagnosis of leptospiral uveitis. Geographic location of the patient, occupation, socio-economic status, risk factors related to exposure, past history of fever or jaundice also aid in diagnosis.Steroids are the mainstay of treatment for leptospiral uveitis. Depending upon the severity and anatomical location of inflammatory lesion, topical, peri-ocular and/or systemic steroids are given. The prognosis is generally good, even when the inflammation is severe.

  16. Phenomenology of Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Hewett, J.L.; /SLAC

    2006-11-07

    If the structure of spacetime is different than that readily observed, gravitational physics, particle physics and cosmology are all immediately affected. The physics of extra dimensions offers new insights and solutions to fundamental questions arising in these fields. Novel ideas and frameworks are continuously born and evolved. They make use of string theoretical features and tools and they may reveal if and how the 11-dimensional string theory is relevant to our four-dimensional world. We have outlined some of the experimental observations in particle and gravitational physics as well as astrophysical and cosmological considerations that can constrain or confirm these scenarios. These developing ideas and the wide interdisciplinary experimental program that is charted out to investigate them mark a renewed effort to describe the dynamics behind spacetime. We look forward to the discovery of a higher dimensional spacetime.

  17. Qubits from extra dimensions

    CERN Document Server

    Lévay, Péter

    2011-01-01

    We link the recently discovered black hole-qubit correspondence to the structure of extra dimensions. In particular we show that for toroidal compactifications of type IIB string theory simple qubit systems arise naturally from the geometrical data of the tori parametrized by the moduli. We also generalize the recently suggested idea of the attractor mechanism as a distillation procedure of GHZ-like entangled states on the event horizon, to moduli stabilization for flux attractors in F-theory compactifications on elliptically fibered Calabi-Yau four-folds. Finally using a simple example we show that the natural arena for qubits to show up is an embedded one within the realm of fermionic entanglement of quantum systems with indistinguishable constituents.

  18. SCONUL Research Extra

    Directory of Open Access Journals (Sweden)

    John Hall

    2006-04-01

    Full Text Available SCONUL Research Extra is a cooperative access and borrowing scheme for staff and research students in UK and Irish higher education institutions. Under the terms of the scheme, eligible researchers may visit any participating library and register as an external borrower. The scheme is run on behalf of SCONUL, the Society of College, National and University Libraries which represents the directors of the library and information services in all the universities of the United Kingdom and Ireland, and in most other UK institutions of higher education, and the directors of the national libraries; it is for all institutions in membership of SCONUL able to lend library materials and, with 158 institutions signed up, it is now the largest reciprocal borrowing scheme in the UK and Ireland, serving almost the entire membership of SCONUL.

  19. Ocular vestibular evoked myogenic potentials in normal-hearing adults

    OpenAIRE

    Mohammad Kamali; Homa Zarinkoub; Akram Pourbakht; Abdoreza Sheibanizade; Maryam Ramezani; Seyede Nazanin Hajari

    2012-01-01

    Background and Aim: Ocular vestibular-evoked myogenic potential (oVEMP) is a novel vestibular function test. This short-latency response can be recorded through contracting extraocular muscles by high-intensity acoustic stimulation and can be used to evaluate contralateral ocular-vestibular reflex. The aim of this study was to record and compare the amplitude, latency, asymmetry ratio and occurrence percentage of oVEMP (n10) and cervical VEMP (p13) responses in a group of normal adult subject...

  20. Ocular allergy and keratoconus

    Directory of Open Access Journals (Sweden)

    Namrata Sharma

    2013-01-01

    Full Text Available Keratoconus is the most common corneal ectatic disorder, the cause of which is largely unknown. Many factors have been implicated, and the ocular allergy is being one of them. The commonly proposed pathogenesis includes the release of inflammatory mediators due to eye rubbing which may alter the corneal collagen and lead to corneal ectasias. The onset of keratoconus is often early in cases associated with allergy and routine corneal topography may detect subtle forms of keratoconus. These cases may require early keratoplasty and are at an increased risk of having acute corneal hydrops. Surgical outcomes are similar to primary keratoconus cases. However, post-operative epithelial breakdown may be a problem in these cases. Control of allergy and eye rubbing is the best measure to prevent corneal ectasias in cases of ocular allergy.

  1. Miopatia ocular descendente

    Directory of Open Access Journals (Sweden)

    Nunjo Finkel

    1972-06-01

    Full Text Available São relatados 4 casos de miopatia ocular descendente (MOD com história familial levantada em três gerações. Biópsia musculares e eletromiografia em um caso confirmaram o caráter miogênico da doença. A MOD nada mais seria do que uma forma clínica especial de distrofia muscular, de início tardio.

  2. Ocular sparganosis from Assam

    Science.gov (United States)

    Nath, Reema; Gogoi, Rajendra Nath

    2015-01-01

    Sparganosis is caused by plerocercoid larvae of the Pseudophyllidea tapeworms of the genus Spirometra. Though prevalent in East Asian and south east Asian countries like China, Japan, Korea, Taiwan, Vietnam, Thailand; yet very few cases are reported from India. We report a case of migrating sub-conjunctival ocular sparganosis mimicking scleritis which later on developed into orbital cellulitis from Dibrugarh, Assam, North-eastern part of India. This case is reported for its rarity. PMID:25709957

  3. Ocular injury in hurling.

    LENUS (Irish Health Repository)

    Flynn, T H

    2012-02-03

    OBJECTIVES: To describe the clinical characteristics of ocular injuries sustained in hurling in the south of Ireland and to investigate reasons for non-use of protective headgear and eye wear. METHODS: Retrospective review of the case notes of 310 patients who attended Cork University Hospital or Waterford Regional Hospital between 1 January 1994 and 31 December 2002 with ocular injuries sustained during a hurling match. A confidential questionnaire on reasons for non-use of protective headgear and eye wear was completed by 130 players. RESULTS: Hurling related eye injuries occurred most commonly in young men. Fifty two patients (17%) required hospital admission, with hyphaema accounting for 71% of admissions. Ten injuries required intraocular surgical INTERVENTION: retinal detachment repair (5); macular hole surgery (1); repair of partial thickness corneal laceration (1); repair of globe perforation (1); enucleation (1); trabeculectomy for post-traumatic glaucoma (1). Fourteen eyes (4.5%) had a final best corrected visual acuity (BCVA) of <6\\/12 and six (2%) had BCVA <3\\/60. In the survey, 63 players (48.5%) reported wearing no protective facemask while playing hurling. Impairment of vision was the most common reason cited for non-use. CONCLUSIONS: Hurling related injury is a significant, and preventable, cause of ocular morbidity in young men in Ireland. The routine use of appropriate protective headgear and faceguards would result in a dramatic reduction in the incidence and severity of these injuries, and should be mandatory.

  4. Using Extra Credit to Facilitate Extra Learning in Students

    Directory of Open Access Journals (Sweden)

    Mohammad Muztaba Fuad

    2012-06-01

    Full Text Available Giving students extra credit work is a hotly debated pedagogical issue. This paper shares experience of using extra credit quizzes to push students to think critically and beyond the boundaries. This particular type of quizzes are not announced before and presented to students as a surprise quiz. A certain percentage of the grade earned in these quizzes was included in student’s final grade calculations. With a well-developed model of questions, quiz structure and grade calculation, the presented model of extra credit eliminates negativity related to extra credit work and also motivates students into course work. Our findings showed that by relieving students from the mental pressure of test taking and by making those tests/quizzes as extra credit; students actually performs better in solving harder problems and eventually learns more of the advanced course topics.

  5. OCULAR COLOBAMATA IN A FAMILY

    Directory of Open Access Journals (Sweden)

    Sheetal

    2015-04-01

    Full Text Available AIM: To identify the proportion of cases affected in a family with ocular colobamata . MATERIAL: Ocular colobomata present in a family METHOD: Visual acuity, Slit lamp examination, Ophthalmoscopy, Fundus Photography, B - Scan, Family members were examined. RESULTS: Family showed poor visual acuity, Iris and Choridal Coloboma without optic disc involvement and normal corneal diameter. CONCLUSION: Ocular coloboma occurring in patients of my study is family and genetically determined.

  6. Extra Low ENergy Antiproton

    CERN Multimedia

    To produce dense antiproton beams at very low energies (110 keV), it has been proposed to install a small decelerator ring between the existing AD ring and the experimental area. Phase-space blowup during deceleration is compensated by electron cooling such that the final emittances are comparable to the 5MeV beam presently delivered by the AD. An immediate consequence is a significant increase in the number of trapped antiprotons at the experiments as outlined in the proposal CERN/SPSC-2009-026; SPCS-P-338. This report describes the machine parameters and layout of the proposal ELENA (Extra Low ENergy Antiproton)ring also gives an approximate estimate of cost and manpower needs. Since the initial estimate, published in 2007 (CERN-AB-2007-079), the ELENA design has evolved considerably. This is due to a new location in the AD hall to acommodate for the possibility of another experimental zone, as suggested by the SPCS, and also due to improvements in the ring optics and layout. The cost estimate that is prese...

  7. [Raise awareness of IgG4 relative ocular disease].

    Science.gov (United States)

    Wei, Shihui; Li, Hongyang

    2015-12-01

    Purpose IgG4-related ocular disease is a chronic systemic disease with lymphocyte abnormal. The lacrimal glands, extraocular muscles and infraorbital nerve were often involved which was often the first symptom of systemic disease. While ophthalmologists did not know this disease well. They usually misdiagnosed it as idiopathic inflammatory pseudotumor, thyroid-associated ophthalmopathy etc, which resulted in delayed treatments. Here pathogenesis, clinical features and treatment methods of IgG4-relative ocular disease were described in order to improve awareness of this ocular disease, reduce clinical misdiagnosis, improve disease prognosis and standardized treatment. As the incidence of this disease increased in recent years, it is very necessary to improve awareness of the disease for ophthalmologists.

  8. Prevalence of bacterial pathogens causing ocular infections in South India

    Directory of Open Access Journals (Sweden)

    Ramesh S

    2010-04-01

    Full Text Available Background / Aims: The eye may be infected from external sources or through intra-ocular invasion of micro-organisms carried by the blood stream. This study was undertaken to isolate and identify the specific bacterial pathogens causing ocular infections and to determine their in-vitro antibacterial susceptibilities to commonly used antibacterial agents. Materials and Methods: A retrospective analysis of all patients with clinically diagnosed bacterial ocular infections such as blepharitis, conjunctivitis, internal and external hordeolum, suppurative scleritis, canaliculitis, keratitis, dacryocystitis, preseptal cellulitis, endophthalmitis and panophthalmitis presenting between January 2005 and December 2005 was performed. Extra-ocular and intra-ocular specimens were collected and were subjected to direct microscopy and culture. Results: A total of 756 patients with bacterial ocular infections were analyzed, of which 462(61% eyes had adnexal bacterial infection, 217(28.7% had corneal infection, 6 (0.8% had scleral involvement and the remaining 71(9.39% eyes had infection of the intra-ocular tissues. The predominant bacterial species isolated was S. aureus (195 of 776; 25% followed by S. pneumoniae (169 of 776; 21.78% and coagulase negative staphylococci (142 of 776; 18.3%. The largest number of gram-positive isolates were susceptible to cefazolin (545 of 624; 87.34%, chloramphenicol (522 of 624; 83.65% and gatifloxacin (511 of 624; 81.89% and gram-negative isolates were to amikacin (127 of 136; 93.38%, gatifloxacin (125 of 136; 91.91% and ofloxacin (119 of 136; 87.5%, while aerobic actinomycetes were to amikacin (100%, gatifloxacin (14 of 16; 87.5%, chloramphenicol (14 of 16; 87.5% and ofloxacin (13 of 16; 81.25%. Conclusions: S. aureus frequently causes infections of eyelids and conjunctiva, S. pneumoniae of lacrimal apparatus and cornea and coagulase negative staphylococci causes intra-ocular infections. Of all routinely used antibacterials

  9. Discriminative Ocular Artifact Correction for Feature Learning in EEG Analysis.

    Science.gov (United States)

    Li, Xinyang; Guan, Cuntai; Zhang, Haihong; Ang, Kai Keng

    2016-11-16

    Electrooculogram (EOG) artifact contamination is a common critical issue in general electroencephalogram (EEG) studies as well as in brain computer interface (BCI) research. It is especially challenging when dedicated EOG channels are unavailable or when there are very few EEG channels available for ICA-based ocular artifact removal. It is even more challenging to avoid loss of the signal of interest during the artifact correction process, where the signal of interest can be multiple magnitudes weaker than the artifact. To address these issues, we propose a novel discriminative ocular artifact correction approach for feature learning in EEG analysis.Without extra ocular movement measurements, the artifact is extracted from raw EEG data, which is totally automatic and requires no visual inspection of artifacts. Then, artifact correction is optimized jointly with feature extraction by maximizing oscillatory correlations between trials from the same class and minimizing them between trials from different classes. We evaluate this approach on a real world EEG data set comprising 68 subjects performing cognitive tasks. The results showed that the approach is capable of not only suppressing the artifact components but also improving the discriminative power of a classifier with statistical significance. We also demonstrate that the proposed method addresses the confounding issues induced by ocular movements in cognitive EEG study.

  10. Ocular defects in cerebral palsy

    Directory of Open Access Journals (Sweden)

    Katoch Sabita

    2007-01-01

    Full Text Available There is a high prevalence of ocular defects in children with developmental disabilities. This study evaluated visual disability in a group of 200 cerebral palsy (CP patients and found that 68% of the children had significant visual morbidity. These findings emphasize the need for an early ocular examination in patients with CP.

  11. Fetal ocular measurements by MRI.

    Science.gov (United States)

    Li, Xiao Bing; Kasprian, Gregor; Hodge, Jacqueline C; Jiang, Xiao Li; Bettelheim, Dieter; Brugger, Peter C; Prayer, Daniela

    2010-11-01

    To present fetal magnetic resonance imaging (MRI) ocular measurement ranges by gestational age (GA) in normal and growth-restricted fetuses. A total of 298 pregnant women from the 18th to the 39th week of gestation were imaged using MRI. Ocular measurements including binocular distance (BOD), interocular distance (IOD), transverse ocular diameter (OD) and anterior-posterior (AP) OD were measured. The curve estimation analyses for linear, logarithmic and quadratic models were performed. The ocular measurements of the fetuses with intrauterine growth restriction (IUGR) were compared with that of the normal fetuses. The fetal eye resembles an ellipsoid with significantly longer OD and shorter AP (t = - 22.07, p < 0.001). The quadratic model was the best model in predicting growth of the fetal BOD, IOD, OD and AP. The ocular measurements of the fetuses with IUGR were significantly different from that of the normal fetuses (BOD: t = 3.58, p < 0.001; IOD: t = 5.73, p < 0.001; OD: t = 3.52, p < 0.001; AP: t = 2.19, p < 0.05). Fetal ocular growth can be readily assessed by fetal MRI. Using the normative data provided in this study, fetal ocular anomalies may be detected. Ocular size is frequently reduced in the condition of IUGR, with potential pathologic impact on postnatal vision.

  12. Supersymmetry breaking with extra dimensions

    Indian Academy of Sciences (India)

    Fabio Zwirner

    2004-02-01

    This talk reviews some aspects of supersymmetry breaking in the presence of extra dimensions. The first part is a general introduction, recalling the motivations for supersymmetry and extra dimensions, as well as some unsolved problems of four-dimensional models of supersymmetry breaking. The central part is a more focused introduction to a mechanism for (super)symmetry breaking, proposed first by Scherk and Schwarz, where extra dimensions play a crucial role. The last part is devoted to the description of some recent results and of some open problems.

  13. Inflation from periodic extra dimensions

    CERN Document Server

    Higaki, Tetsutaro

    2016-01-01

    We discuss a realization of a small field inflation based on string inspired supergravities. In theories accompanying extra dimensions, compactification of them with small radii is required for realistic situations. Since the extra dimension can have a periodicity, there will appear (quasi-)periodic functions under transformations of moduli of the extra dimensions in low energy scales. Such a periodic property can lead to a UV completion of so-called multi-natural inflation model where inflaton potential consists of a sum of multiple sinusoidal functions with a decay constant smaller than the Planck scale. As an illustration, we construct a SUSY breaking model, and then show that such an inflaton potential can be generated by a sum of world sheet instantons in intersecting brane models on extra dimensions containing $T^2/{\\mathbb Z}_2$ orbifold. We show also predictions of cosmic observables by numerical analyzes.

  14. Phenomenology of universal extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Kong, Kyoungchul; Matchev, Konstantin T.; /Florida U.

    2006-10-01

    In this proceeding, the phenomenology of Universal Extra Dimensions (UED), in which all the Standard Model fields propagate, is explored. We focus on models with one universal extra dimension, compactified on an S{sub 1}/Z{sub 2} orbifold. We revisit calculations of Kaluza-Klein (KK) dark matter without an assumption of the KK mass degeneracy including all possible coannihilations. We then contrast the experimental signatures of low energy supersymmetry and UED.

  15. Ocular myositis: insights into recurrence and semiological presentation.

    Science.gov (United States)

    Martins, William Alves; Marrone, Luiz Carlos Porcello; Saute, Ricardo; Becker, Jefferson; Vargas, José Amadeu Almeida; da Costa Vargas, Juliana Ferreira; Marrone, Antonio Carlos Huf

    2015-01-01

    Ocular myositis (OM) is a rare clinical entity characterized by idiopathic, nonspecific inflammation of primarily or exclusively extraocular muscles (EOM). Presentation usually encompasses painful diplopia, exacerbated by eye movement. We report two cases of idiopathic OM with unique characteristics. The first presented with pseudo-sixth nerve palsy due to medial nucleus inflammation and the second presented with recurrent OM, subsequently affecting both eyes. Knowledge of different patterns of presentation and recurrence are important to manage this rare inflammatory syndrome.

  16. Ocular involvement in pemphigus vulgaris.

    Science.gov (United States)

    Akhyani, Maryam; Keshtkar-Jafari, Alireza; Chams-Davatchi, Cheyda; Lajevardi, Vahide; Beigi, Sara; Aghazadeh, Nessa; Rayati Damavandi, Maede; Arami, Shabnam

    2014-07-01

    Pemphigus vulgaris (PV) is an autoimmune disorder affecting the skin and mucous membranes. Ocular involvement in PV has been reported but its prevalence and clinical characteristics are not well defined. This prospective cross-sectional study of 103 PV patients was designed to determine the prevalence, clinical types and epidemiological trends of ocular involvement in a population of Iranian patients with PV. Ocular involvement was present in 17 (16.5%) patients. Conjunctivitis was the most prevalent type of ocular involvement (9/17, 52.9%), followed by erosion of the palpebral conjunctiva (7/17, 41.2%). Erosion of the bulbar conjunctiva was noted in only one patient (5.9%). The most commonly reported symptoms were eye irritation (76.5%) and redness (76.5%). No significant relation was found between ocular involvement and disease activity (partial remission or relapse). Mucoid discharge was significantly more common in patients with conjunctival erosions as compared to patients with conjunctivitis (P = 0.038). We conclude that ocular involvement is not rare in PV; 16.5% of PV patients develop ocular disease independent of the disease activity and extension. Conjunctivitis is the most common type of involvement, however, palpebral conjunctival erosion is more frequent than previously realized.

  17. An effective solution for capturing the single twitch of muscle: application to monitor muscle relaxation.

    Science.gov (United States)

    Colak, Omer H; Girard, Emmanuelle; Krejci, Eric

    2014-09-01

    In this study, a fast algorithm was developed to capture of train of four and to filter extra contraction and noises. A low pass filter created to filter extra contraction and high frequency noises. Then, a TCA algorithm designed to capturing of the single twitch of muscle. The algorithm updated to remove embedded extra contraction and to derive boundary values in this location from cubic spline interpolation. Efficiency of TCA and effect of extra contraction tested in time and frequency domain.

  18. Sports related ocular injuries.

    Science.gov (United States)

    Mishra, Avinash; Verma, Ashok K

    2012-07-01

    Every year > 600,000 sports and recreation related eye injuries occur, out of which roughly 13,500 of these result in permanent loss of sight. Up to 90% of these sports related eye injuries are preventable by using adequate eye protection equipment. Protective eyewear is made of polycarbonate, a highly impact-resistant plastic which is now easily available as prescription and non-prescription eyewear and all players should be encouraged to use them. The medical officers by educating their patients regarding the risks of eye injuries in various sports and the confirmed benefits of using protective equipment have the potential to prevent injury to over thousands of eyes every year. The medical fraternity can also play a very important role in educating the coaches, parents, and children and thus put an end to unnecessary blindness and vision loss from sports related ocular injuries, therefore ensuring a lifetime of healthy vision.

  19. Ocular histoplasmosis syndrome.

    Science.gov (United States)

    Diaz, Rocio I; Sigler, Eric J; Rafieetary, Mohammad R; Calzada, Jorge I

    2015-01-01

    Ocular histoplasmosis syndrome (OHS) is a chorioretinal disorder with a distinct fundus appearance that is commonly found in regions endemic for Histoplasma capsulatum. Choroidal neovascularization (CNV) secondary to OHS is considered one of the principal causes of central vision loss among young adults in endemic areas. Although there is no consensus regarding its pathogenesis, evidence points to Histoplasma capsulatum as the most probable etiology. Once considered an intractable hemorrhagic maculopathy, CNVs are now treatable. Extrafoveal CNVs are successfully treated with laser photocoagulation. Subfoveal and juxtafoveal CNVs are managed with anti-vascular endothelial growth factor therapy, photodynamic therapy, or a combination of both. Modern imaging technologies such as spectral-domain optical coherence tomography have improved our diagnostic abilities, making it easier to monitor disease activity and CNV regression. We review the epidemiology, pathogenesis, clinical manifestations, differential diagnosis, and current treatment of this disease.

  20. Ocular tuberculosis: current perspectives

    Directory of Open Access Journals (Sweden)

    Shakarchi FI

    2015-11-01

    Full Text Available Faiz I Shakarchi1,21Ibn Al-Haetham Teaching Eye Hospital, 2Department of Opthalmology, Medical College, Al-Mustansiriya University, Baghdad, IraqAbstract: The World Health Organization currently estimates that nearly two billion people, or one-third of the world’s population, are infected by tuberculosis, and that roughly 10% of the infected people are symptomatic. Tuberculosis affects the lungs in 80% of patients, while in the remaining 20% the disease may affect other organs, including the eye. Uveitis can be seen concurrently with tuberculosis, but a direct association is difficult to prove. Ocular tuberculosis is usually not associated with clinical evidence of pulmonary tuberculosis, as up to 60% of extrapulmonary tuberculosis patients may not have pulmonary disease. The diagnosis of tuberculous uveitis is often problematic and in nearly all reported cases, the diagnosis was only presumptive. Tuberculous uveitis is a great mimicker of various uveitis entities and it can be considered in the differential diagnosis of any type of intraocular inflammation. It is still unknown if ocular manifestations result from a direct mycobacterium infection or hypersensitivity reaction and this is reflected on the management of tuberculous uveitis. Prevalence of tuberculosis as an etiology of uveitis may reach up to 10% in endemic areas. Tuberculous uveitis is a vision-threatening disease that inevitably leads to blindness if not properly diagnosed and treated. The aim of this review is to illustrate the various clinical features and management of presumed tuberculous uveitis. The current review focuses on the diagnostic criteria, significance of tuberculin skin test, and use of systemic corticosteroids in the management of tuberculous uveitis as recommended in recent publications.Keywords: tuberculosis, uveitis, choroiditis, tuberculin skin test

  1. Ocular manifestations of feline herpesvirus.

    Science.gov (United States)

    Andrew, S E

    2001-03-01

    Feline herpesvirus-1 (FHV-1) infection is ubiquitous in the domestic cat population worldwide. The most common clinical ocular manifestations of infection with FHV-1 are conjunctivitis and keratitis. This paper reviews the pathogenesis of feline herpesvirus-1 and discusses the various clinical ocular manifestations, diagnostic techniques and treatment of FHV-1-induced diseases. Ocular manifestations include: conjunctivitis, keratitis, stromal keratitis, keratoconjunctivitis sicca, ophthalmia neonatorium, symblepharon, corneal sequestrum, eosinophilic keratitis and anterior uveitis. Diagnostic techniques discussed include: virus isolation, fluorescent antibody testing, serum neutralising titers, ELISA and polymerase chain reaction. Various therapies are also discussed.

  2. Ocular Blood Flow Autoregulation Mechanisms and Methods

    Directory of Open Access Journals (Sweden)

    Xue Luo

    2015-01-01

    Full Text Available The main function of ocular blood flow is to supply sufficient oxygen and nutrients to the eye. Local blood vessels resistance regulates overall blood distribution to the eye and can vary rapidly over time depending on ocular need. Under normal conditions, the relation between blood flow and perfusion pressure in the eye is autoregulated. Basically, autoregulation is a capacity to maintain a relatively constant level of blood flow in the presence of changes in ocular perfusion pressure and varied metabolic demand. In addition, ocular blood flow dysregulation has been demonstrated as an independent risk factor to many ocular diseases. For instance, ocular perfusion pressure plays key role in the progression of retinopathy such as glaucoma and diabetic retinopathy. In this review, different direct and indirect techniques to measure ocular blood flow and the effect of myogenic and neurogenic mechanisms on ocular blood flow are discussed. Moreover, ocular blood flow regulation in ocular disease will be described.

  3. Ocular comparative anatomy of the family Rodentia.

    Science.gov (United States)

    Rodriguez-Ramos Fernandez, Julia; Dubielzig, Richard R

    2013-07-01

    There is little information regarding ocular anatomy and histology in many of the rodent species. Histological analyses for morphologic features were performed in 31 globes from 18 rodent species submitted to and archived at the Comparative Ocular Pathology Laboratory of Wisconsin. The following measurements were taken: thickness of the cornea, corneal epithelium, corneal stroma, Descemet's membrane, and retina. H&E sections were evaluated for the following anatomical features: presence of pigmented epithelial cells in the peripheral cornea, presence and location of Schlemm's canal, presence of iridal sphincter and dilator and ciliary body muscles, presence of pars plicata and plana, presence of retinal vessels, presence of lamina cribrosa, and presence of tapetum lucidum. The springhaas was the only rodent in our collection that presented a well-developed tapetum lucidum fibrosum. The presence of retinal vessels was variable: vessels were observed in all of the members of the mouse-related clade, except the springhaas and the beaver, in all of the squirrel-related clade members, and in none of the Ctenohystrica. In the flying squirrels, blood vessels extended to the outer limiting membrane in the photoreceptor layer. Beavers, chinchillas, capybara, and guinea pigs lacked vessels within the retina; however, they had vessels within the optic nerve head. Ground squirrels have an optic nerve head, which is linear in the horizontal plane and an asymmetric retina. The tree-dwelling squirrels have a rounded but still elongated optic nerve, and the flying squirrel has a round optic nerve head like all the other rodents.

  4. Miastenia grave ocular Severe ocular myastenia

    Directory of Open Access Journals (Sweden)

    Yaimir Estevéz Miranda

    2010-01-01

    Full Text Available La miastenia grave es una enfermedad autoinmune de la unión neuromuscular que se caracteriza por la variabilidad de la debilidad muscular, que empeora o está provocada por el ejercicio del músculo o de los grupos musculares implicados, mientras que el descanso la mejora. La primera descripción de la enfermedad data de 1672, su relación con una afección del timo no se estableció hasta 1901. La enfermedad es poco frecuente, afecta a todas las etnias por igual, y no tiene predilección geográfica. Se reporta un paciente masculino de 28 años de edad atendido en el Servicio de Oftalmología Pediátrica del Instituto Cubano de Oftalmología "Ramón Pando Ferrer" por presentar visión doble, ptosis palpebral ligera en ojo derecho que empeora con el transcurso del día. Por el interrogatorio y el cuadro clínico se sospecha de una miastenia grave, se remite al clínico y el neurólogo. En los estudios realizados de neuroimágenes, tomografía y electroencefalograma no se encontraron alteraciones. Se decide valorar el caso con el servicio de Neuroftalmología de nuestro centro y por el Instituto de Neurología y es confirmado el diagnóstico.Myasthenia gravis is an autoimmune illness of the neuromuscular joint that is characterized by the variability of the muscular weakness that worsens or caused by exercising of the muscle or the involved muscular groups; resting helps in improving the condition of the muscle. The first description of the illness dates back to 1672, but its linking to a thymus disorder was not discovered until 1901. This illness is not very frequent, affects equally to all the races, and it does not predominate in any particular geographic region. This paper presented a male patient aged 28 years who went to the Ophthalmologic Service at "Ramón Pando Ferrer" Cuban Institute of Ophthalmology because he suffered from double vision, slight palpebral ptosis in his right eye that became worse as the day went by. After the

  5. Impact of Microbiome on Ocular Health

    OpenAIRE

    Kugadas, Abirami; Gadjeva, Mihaela

    2016-01-01

    The ocular surface is continuously exposed to the environment and, therefore, it is surprising that it harbors only few commensals with low degree of diversity. This unique aspect of the ocular surface physiology prompts the question whether there are core ocular commensal communities and how they affect ocular immunity. The purpose of this review is to provide an overview of what is known about the ocular surface commensals in health and disease and what we would like to learn in the near fu...

  6. Ocular perfusion pressure in glaucoma.

    Science.gov (United States)

    Costa, Vital P; Harris, Alon; Anderson, Douglas; Stodtmeister, Richard; Cremasco, Fernanda; Kergoat, Helene; Lovasik, John; Stalmans, Ingborg; Zeitz, Oliver; Lanzl, Ines; Gugleta, Konstantin; Schmetterer, Leopold

    2014-06-01

    This review article discusses the relationship between ocular perfusion pressure and glaucoma, including its definition, factors that influence its calculation and epidemiological studies investigating the influence of ocular perfusion pressure on the prevalence, incidence and progression of glaucoma. We also list the possible mechanisms behind this association, and discuss whether it is secondary to changes in intraocular pressure, blood pressure or both. Finally, we describe the circadian variation of ocular perfusion pressure and the effects of systemic and topical medications on it. We believe that the balance between IOP and BP, influenced by the autoregulatory capacity of the eye, is part of what determines whether an individual will develop optic nerve damage. However, prospective, longitudinal studies are needed to better define the role of ocular perfusion pressure in the development and progression of glaucoma.

  7. OCULAR COMPLICATIONS IN ATOPIC DERMATITIS

    Institute of Scientific and Technical Information of China (English)

    SHEN Xi; XU Ge-zhi; JIAO Qin; LI Xia; SHI Ruo-fei

    2008-01-01

    Objective To describe the ocular complications of 62 patients with active atopic dermatitis( AD) during the period of 2003 2006. Methods Routine ophthalmic examinations, including slit-lamp microscope, indirect ophthalmoscope or Goldmann three-mirror lens, A-scan and B-scan ultrasound, ultrasound biomicroscope (UBM) and corneal topography, as well as tear film break-up time (BUT) and Schirmer tests were carried out. Results Cataract (28 eyes), keratoconjunctivitis (42 eyes), superficial punctate keratopathy (45 eyes) and tear function abnormality ( 76 eyes) were major ocular complications in AD patients. Retinal detachment (6 eyes) was the most severe ocular complication in the AD patients. Conclusion Ocular complications are common in AD patients and a very careful examination of eyes is essential in treating AD patients. If the eyes can be examed carefully and in time, some operations and severe complications can be avoidable, especially for the patients with retinal breaks or retinal detachment.

  8. Ocular complications of malaria treatment

    African Journals Online (AJOL)

    2011-10-08

    Oct 8, 2011 ... parenteral quinine are employed with consequent untoward effects. This article reports two cases of severe ocular toxicity, including mimicry of ... 2003 at the Ebony Eye Specialist Clinic Onitsha with a week history of double ...

  9. Ocular toxocariasis. A case presentation

    Directory of Open Access Journals (Sweden)

    Mariela Julia Curbelo Gómez

    2008-12-01

    Full Text Available A clinical case on ocular toxocariasis is presented. The clinical manifestations were pain and red eye in a four year-old child. A prior acute uveitis in the LE was found in the physical ocular exam. Vitrea band that was out of the superior edge of papila and a marginal granuloma were found in the eyes fundus. The patient was admitted and treated with oral corticoids and oral antihelmintics

  10. Air bags and ocular injuries.

    OpenAIRE

    Stein, J.D.; Jaeger, E A; Jeffers, J B

    1999-01-01

    PURPOSE: This investigation retrospectively examined ocular injuries associated with air bag deployment to gain a better appreciation of potential risk factors in motor vehicle accidents. National statistics regarding the efficacy of air bags were reviewed. METHODS: Review of the literature from 1991 to 1998 identified 44 articles describing 97 patients with air-bag-induced ocular injuries. Variables extracted from each case were age, sex, height, position in the car, eye wear, vehicle impact...

  11. [Ocular metastasis heralding gastric adenocarcinoma].

    Science.gov (United States)

    Chekrine, T; Tawfiq, N; Bouchbika, Z; Benchakroun, N; Jouhadi, H; Sahraoui, S; Benider, A

    2010-10-01

    Ocular metastasis is a rare presenting feature of gastric adenocarcinoma. We report a 48-year-old woman who presented with a decrease in visual acuity of the right eye leading to the discovery of an ocular metastasis. Diagnostic work-up identified a gastric adenocarcinoma with pulmonary metastases. She received four cycles of chemotherapy combining epirubicin, cisplatin and fluorouracil. The patient died 6 months after the diagnosis of respiratory failure.

  12. Cicatricial changes in ocular pemphigus

    Science.gov (United States)

    Chirinos-Saldaña, P; Zuñiga-Gonzalez, I; Hernandez-Camarena, J C; Navas, A; Ramirez-Luquin, T; Robles-Contreras, A; Jimenez-Martinez, M C; Ramirez-Miranda, A; Bautista-de Lucio, V M; Graue-Hernandez, E O

    2014-01-01

    Purpose To describe the clinical characteristics of ocular involvement in patients with pemphigus at an ophthalmological referral center. Methods A retrospective review was conducted on patients with the immunopathological diagnosis of pemphigus examined between 1 January 2000 and 1 April 2010. Uncorrected distance visual acuity (UDVA), best corrected distance visual acuity (BCVA), ocular symptoms, and ocular surface inflammatory and scarring changes were assessed. Results A total of 15 patients were identified, with a mean age of 68.27±14.35 years, and 80% (n=12) were female. Extraocular involvement was reported in one patient. All of the eyes showed cicatricial changes in the conjunctiva. In all, 6 eyes (20%) were classified as stage I; 12 eyes (40%) as stage II; 10 eyes (33%) as stage III; and 2 eyes (7%) as stage IV. A statistically significant association was found between BCVA and the severity of ocular involvement. The mean BCVA logMAR was 1.66 (20/914), with a range from logMAR 0 (20/20) to logMAR 4 (NLP). Other ocular diseases were found in 8 (53.3%), systemic diseases in 10 (66.7%), and the use of pemphigus-inducing drugs in 10 patients (66.7%). Conclusions The present report represents the largest series of ocular involvement in pemphigus confirmed by immunopathology. The clinical manifestations varied from conjunctival hyperemia to corneal scarring and perforation. There was a strong association between scarring changes and low BCVA. Ocular and systemic diseases as well as the use of pemphigus-inducing drugs may predispose to ocular cicatricial changes observed in this series. PMID:24480839

  13. Trauma ocular y politrauma Ocular trauma and multitrauma

    Directory of Open Access Journals (Sweden)

    Dunia Cruz Izquierdo

    2012-01-01

    Full Text Available Se realizó una revisión sobre el trauma ocular y su manejo en pacientes politraumatizados. Entre las causas más frecuentes de trauma ocular se encuentran los accidentes domésticos, laborales, juegos, actividades recreativas y deportivas. Involucran en un alto por ciento a niños y jóvenes, y predomina el sexo masculino en casi todos los trabajos revisados. No solo en Cuba sino en el mundo, el trauma ocular es fuente importante de ceguera unilateral o bilateral. Se presenta un breve compendio de los términos y definiciones actuales que son utilizados para el manejo del trauma ocular, su clasificación y la ventaja que ofrece aplicar el Puntaje del Trauma Ocular, OTS (Ocular Trauma Score, para el pronóstico de la agudeza visual final de acuerdo a los hallazgos clínicos encontrados en la evaluación inicial. Se hace referencia a los pacientes con politrauma y los aspectos a tener en cuenta por el oftalmólogo para tomar conducta cuando estos presentan heridas penetrantes o perforantes y tienen compromiso vital. En estos casos se hace necesaria la colaboración urgente de múltiples especialistas para primero mantener al paciente con vida y luego disminuir las complicaciones que repercuten en su pronóstico visual.A review was made on the ocular trauma and its management in multitrauma patients. The most common causes comprise domestic and occupational accidents, games, recreational and sport activities. It involves more frequently a high percentage of young people, with male prevalence in almost all the reviewed papers. Ocular trauma is an important source of unilateral or bilateral blindness not only in Cuba but worldwide as well. A brief summary of the current terms and definitions used to manage ocular trauma, their classification and the advantage of the Ocular Trauma Score (OTS to know the possible final visual acuity, according to the clinical findings at the emergency room, were presented. Reference was also made to the multitrauma

  14. Extra Stimulation in Intermediate Grade Reading.

    Science.gov (United States)

    Mason, George E.

    Three types of extra stimulation in reading are discussed: extra teacher time devoted to teaching reading, extra student time devoted to practice in reading, and extra motivation and reinforcement leading to greater amounts of student reading outside the school. Problems are created (1) when teaching time spent on reading is increased in the…

  15. Ocular allergy latin american consensus

    Directory of Open Access Journals (Sweden)

    Myrna Serapião dos Santos

    2011-12-01

    Full Text Available PURPOSE: To establish current definition, classification and staging, and to develop diagnosis and treatment recommendations for ocular allergy, by using Delphi approach. METHODS: Ten Latin American experts on ocular allergy participated in a 4-round Delphi panel approach. Four surveys were constructed and answered by panelists. A two-thirds majority was defined as consensus. Definition, classification, staging and diagnosis and treatment recommendations were the main outcomes. RESULTS: "Ocular allergy" was proposed as the general term to describe ocular allergic diseases. Consensus regarding classification was not reached. Signs and symptoms were considered extremely important for the diagnosis. It was consensus that a staging system should be proposed based on the disease severity. Environmental control, avoidance of allergens and the use of artificial tears were recommended as first line treatment. The secondary treatment should include topical anti-histamines, mast cell stabilizers and multi actions drugs. Topical non-steroidal anti-inflammatory and vasoconstrictors were not recommended. Topical corticosteroids were recommended as third line of treatment for the most severe keratoconjunctivitis. Consensus was not reached regarding the use of systemic corticosteroids or immunosuppressant. Surgical approach and unconventional treatments were not recommended as routine. CONCLUSION: The task of creating guidelines for ocular allergies showed to be very complex. Many controversial topics remain unsolved. A larger consensus including experts from different groups around the world may be needed to further improve the current recommendations for several aspects of ocular allergy.

  16. Ocular toxicity of targeted therapies.

    Science.gov (United States)

    Renouf, Daniel J; Velazquez-Martin, Juan P; Simpson, Rand; Siu, Lillian L; Bedard, Philippe L

    2012-09-10

    Molecularly targeted agents are commonly used in oncology practice, and many new targeted agents are currently being tested in clinical trials. Although these agents are thought to be more specific and less toxic then traditional cytotoxic chemotherapy, they are associated with a variety of toxicities, including ocular toxicity. Many of the molecules targeted by anticancer agents are also expressed in ocular tissues. We reviewed the literature for described ocular toxicities associated with both approved and investigational molecularly targeted agents. Ocular toxicity has been described with numerous approved targeted agents and also seems to be associated with several classes of agents currently being tested in early-phase clinical trials. We discuss the proposed pathogenesis, monitoring guidelines, and management recommendations. It is important for oncologists to be aware of the potential for ocular toxicity, with prompt recognition of symptoms that require referral to an ophthalmologist. Ongoing collaboration between oncologists and ocular disease specialists is critical as the use of molecularly targeted agents continues to expand and novel targeted drug combinations are developed.

  17. Ocular Effects of Sulfur Mustard

    Directory of Open Access Journals (Sweden)

    Yunes Panahi

    2013-06-01

    Full Text Available Purpose: To review current knowledge about ocular effects of sulfur mustard (SM and the associated histopathologic findings and clinical manifestationsMethods: Literature review of medical articles (human and animal studies was accomplished using PubMed, Scopus and ISI databases. A total of 274 relevant articles in English were retrieved and reviewed thoroughly.Results: Eyes are the most sensitive organs to local toxic effects of mustard gas. Ocular injuries are mediated through different toxic mechanisms including: biochemical damages, biomolecular and gene expression modification, induction of immunologic and inflammatory reactions, disturbing ultrastructural architecture of the cornea, and long-lasting corneal denervation. The resulting ocular injuries can roughly be categorized into acute or chronic complications. Most of the patients recover from acute injuries, but a minority of victims will suffer from chronic ocular complications. Mustard gas keratopathy (MGK is a devastating late complication of SM intoxication that proceeds from limbal stem cell deficiency (LSCD.Conclusion: SM induces several different damaging changes in case of ocular exposure; hence leading to a broad spectrum of ocular manifestations in terms of severity, timing and form. Unfortunately, no effective strategy has been introduced yet to inhibit or restore these damaging changes.

  18. Collider searches for extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Landsberg, Greg; /Brown U.

    2004-12-01

    Searches for extra spatial dimensions remain among the most popular new directions in our quest for physics beyond the Standard Model. High-energy collider experiments of the current decade should be able to find an ultimate answer to the question of their existence in a variety of models. Until the start of the LHC in a few years, the Tevatron will remain the key player in this quest. In this paper, we review the most recent results from the Tevatron on searches for large, TeV{sup -1}-size, and Randall-Sundrum extra spatial dimensions, which have reached a new level of sensitivity and currently probe the parameter space beyond the existing constraints. While no evidence for the existence of extra dimensions has been found so far, an exciting discovery might be just steps away.

  19. Flavor Models In Extra Dimensions

    CERN Document Server

    Valadez, J

    2005-01-01

    This thesis consists of implementing flavor symmetries in the context of extra dimensions. To the particle content of the Standard Model we add an additional scalar (flavon) field and we assume that all the fields propagate in the extra-dimensional space-time. When the flavon field acquires a vacuum expectation value the flavor symmetry is effectively broken thus generating the Yukawa textures associated with the particles. An specific model in 5D that reproduces all fermion masses, mixing angles and ratios is presented.

  20. Signatures of Large Extra Dimensions

    CERN Document Server

    Hossenfelder, S; Stöcker, H

    2004-01-01

    String theory suggests modifications of our spacetime such as extra dimensions and the existence of a mininal length scale. In models with addidional dimensions, the Planck scale can be lowered to values accessible by future colliders. Effective theories which extend beyond the standart-model by including extra dimensions and a minimal length allow computation of observables and can be used to make testable predictions. Expected effects that arise within these models are the production of gravitons and black holes. Furthermore, the Planck-length is a lower bound to the possible resolution of spacetime which might be reached soon.

  1. Cosmology With Dynamical Extra Dimensions

    CERN Document Server

    Erickson, J K

    2005-01-01

    Nearly every attempt to unify the fundamental forces incorporates the idea of compact extra dimensions. The notion was introduced by Kaluza and Klein in the 1920s and is an essential part of contemporary string theory and M-theory. In most treatments the extra dimensions are static. We consider the consequences of extra dimensions with time-varying radii. The radii are modeled by light scalar fields. These may have unusual properties which produce observable effects, such as non-canonical kinetic energies, couplings to matter and radiation, and non- minimal coupling to gravity. Extra dimensions may be responsible for dark energy in the late universe. The simplest model of dark energy is characterized by its equation of state. We show that constraints placed on realistic models by the universality of free fall, variation of fundamental constants and metric tests of gravity are often stricter than bounds on the equation of state. Testing the equivalence principle maybe an effective way of distinguishing some qu...

  2. Wormholes leading to extra dimensions

    CERN Document Server

    Bronnikov, K A

    2016-01-01

    In 6D general relativity with a scalar field as a source of gravity, a new type of static wormhole solutions is presented: such wormholes connect our universe with a small 2D extra subspace with a universe where this extra subspace is large, and the whole space-time is effectively 6-dimensional. We consider manifolds with the structure M0 x M1 x M2 , where M0 is 2D Lorentzian space-time while each of M1 an M2 can be a 2-sphere or a 2-torus. After selecting possible asymptotic behaviors of the metric functions compatible with the field equations, we give two explicit examples of wormhole solutions with spherical symmetry in our space-time and toroidal extra dimensions. In one example, with a massless scalar field (it is a special case of a well-known more general solution), the extra dimensions have a large constant size at the "far end"; the other example contains a nonzero potential $V(\\phi)$ which provides a 6D anti-de Sitter asymptotic, where all spatial dimensions are infinite.

  3. Origin of the 'Extra Entropy'

    Science.gov (United States)

    Mushotzky, R.

    2008-01-01

    I will discuss how one can determine the origin of the 'extra entropy' in groups and clusters and the feedback needed in models of galaxy formation. I will stress the use of x-ray spectroscopy and imaging and the critical value that Con-X has in this regard.

  4. Cosmology with dynamical extra dimensions

    Science.gov (United States)

    Erickson, Joel K.

    Nearly every attempt to unify the fundamental forces incorporates the idea of compact extra dimensions. The notion was introduced by Kaluza and Klein in the 1920s and is an essential part of contemporary string theory and M-theory. In most treatments the extra dimensions are static. We consider the consequences of extra dimensions with time-varying radii. The radii are modeled by light scalar fields. These may have unusual properties which produce observable effects, such as non-canonical kinetic energies, couplings to matter and radiation, and non-minimal coupling to gravity. Extra dimensions may be responsible for dark energy in the late universe. The simplest model of dark energy is characterized by its equation of state. We show that constraints placed on realistic models by the universality of free fall, variation of fundamental constants and metric tests of gravity are often stricter than bounds on the equation of state. Testing the equivalence principle maybe an effective way of distinguishing some quintessence models from a cosmological constant. In certain dark energy models the speed of sound is much less than the speed of light. We calculate how this affects the cosmic microwave background and show that the speed of sound may be measurable, provided dark energy is sufficiently dense at decoupling. This is another possible signature of quintessence. Dynamical extra dimensions may have consequences for the early universe. In the cyclic model, the universe is described in terms of a series of contractions and expansions of an extra dimension. The big bang is preceded by a big crunch and quantum fluctuations of the scalar field produce structure in universe. We consider how the fluctuations evolve and build over many cycles and show that there are no observable instabilities or adverse effects. In the cyclic model extra dimensions act as both dark energy and as an agent to cause contraction and a big crunch. Previous theorems suggested that contraction

  5. Ocular manifestations of rheumatoid arthritis and their correlation with anti-cyclic citrullinated peptide antibodies

    Directory of Open Access Journals (Sweden)

    Vignesh AP

    2015-02-01

    Full Text Available Ammapati Paul Pandian Vignesh, Renuka Srinivasan Department of Ophthalmology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India Purpose: To study the ocular manifestations of rheumatoid arthritis and to correlate the role of anti-cyclic citrullinated peptide antibody (anti-CCP antibody with the ocular manifestations.Methods: Three-hundred and ninety-two eyes of the 196 rheumatoid arthritis patients who attended the ophthalmology outpatient department underwent a detailed ocular examination using slit lamp biomicroscopy and ophthalmoscopy. The tear function of all the patients was assessed using Schirmer’s test, tear film break-up time and ocular surface staining. The anti-CCP antibody titers for all the rheumatoid arthritis patients were estimated using enzyme-linked immunosorbent assay tests.Results: Seventy-seven patients (135 eyes, 39% out of the 196 patients studied had ocular manifestations typical of rheumatoid arthritis. Dry eye was the most common manifestation (28%, 54 patients. Of the patients, 78% was females (60 patients. The mean duration of rheumatoid arthritis in patients with ocular manifestations was 5.4±2.7 years and without ocular manifestations was 2.1±1.6years. Three percent of the patients had episcleritis (six patients. Scleritis was present in 2% of the patients (four patients. Peripheral ulcerative keratitis and sclerosing keratitis was present in 1% of the population each (two patients each. Eighty-five percent (66 patients had bilateral manifestations 15% (eleven patients had unilateral manifestations. There was a strong association between the presence of anti-CCP antibodies and ocular manifestations of rheumatoid arthritis which was shown by the statistically significant P-value of <0.0001.Conclusion: Ocular manifestations are a significant part of the extra-articular manifestation of rheumatoid arthritis. Dry eye was the most common ocular manifestation. There was a

  6. Purinergic Receptors in Ocular Inflammation

    Directory of Open Access Journals (Sweden)

    Ana Guzman-Aranguez

    2014-01-01

    Full Text Available Inflammation is a complex process that implies the interaction between cells and molecular mediators, which, when not properly “tuned,” can lead to disease. When inflammation affects the eye, it can produce severe disorders affecting the superficial and internal parts of the visual organ. The nucleoside adenosine and nucleotides including adenine mononucleotides like ADP and ATP and dinucleotides such as P1,P4-diadenosine tetraphosphate (Ap4A, and P1,P5-diadenosine pentaphosphate (Ap5A are present in different ocular locations and therefore they may contribute/modulate inflammatory processes. Adenosine receptors, in particular A2A adenosine receptors, present anti-inflammatory action in acute and chronic retinal inflammation. Regarding the A3 receptor, selective agonists like N6-(3-iodobenzyl-5′-N-methylcarboxamidoadenosine (CF101 have been used for the treatment of inflammatory ophthalmic diseases such as dry eye and uveoretinitis. Sideways, diverse stimuli (sensory stimulation, large intraocular pressure increases can produce a release of ATP from ocular sensory innervation or after injury to ocular tissues. Then, ATP will activate purinergic P2 receptors present in sensory nerve endings, the iris, the ciliary body, or other tissues surrounding the anterior chamber of the eye to produce uveitis/endophthalmitis. In summary, adenosine and nucleotides can activate receptors in ocular structures susceptible to suffer from inflammatory processes. This involvement suggests the possible use of purinergic agonists and antagonists as therapeutic targets for ocular inflammation.

  7. Commensal ocular bacteria degrade mucins.

    Science.gov (United States)

    Berry, M; Harris, A; Lumb, R; Powell, K

    2002-12-01

    Antimicrobial activity in tears prevents infection while maintaining a commensal bacterial population. The relation between mucin and commensal bacteria was assessed to determine whether commensals possess mucinolytic activity, how degradation depends on mucin integrity, and whether mucins affect bacterial replication. Bacteria were sampled from healthy eyes and contact lenses from asymptomatic wearers. Intracellular mucins were extracted and purified from cadaver conjunctivas, and surface mucins from extended wear contact lenses. After exposure to bacteria, changes in mucin hydrodynamic volume (proteolytic cleavage) and subunit charge (oligosaccharide degradation) were assayed by size exclusion and ion exchange chromatography. The effect of mucin on bacterial replication was followed for up to 24 hours from the end of incubation with purified ocular mucins. Ocular bacteria decreased the hydrodynamic volume of intracellular and contact lens adherent mucins, irrespective of glycosylation density. A decrease in mucin sialylation was observed after exposure to commensal bacteria. Subunit charge distributions were generally shifted to lesser negative charge, consistent with loss of charged epitopes. Subunits with high negative charge, observed after digesting lightly adhering contact lens mucins with bacteria, suggest preferential cleavage sites in the mucin molecule. The presence of purified ocular mucin in the medium inhibited bacterial growth. Bacteria in the healthy ocular surface possess mucinolytic activity on both intact and surface processed mucins, targeted to discrete sites in the mucin molecule. Inhibition of bacterial growth by ocular mucins can be seen as part of the mucosal control of microbiota.

  8. Toxoplasmosis and its Ocular Manifestations

    Directory of Open Access Journals (Sweden)

    Koev Kr.

    2014-06-01

    Full Text Available The present review provides general information about the parasitic infection of toxoplasmosis and describes the ways of its transmission. It outlines the importance of the consequences of toxoplasmosis infection and the methods of its prevention. The review traces the harmful effects of the disease on human and animal organisms, the causes and stages of development of the disease. The review specifically focuses on the ocular manifestations of toxoplasmosis which can cause ocular lesions, inflammation and scarring. Herein are described the ways toxoplasmosis can damage the eyes causing chorioretinitis, nystagmus, microphthalmia, etc. Furthermore, the review addresses the problem of how congenital and acquired toxoplasmosis affects eyes. The ocular symptoms of toxoplasmosis include weakened or blurred vision, eyeballs pain, ocular sensitivity to light, etc. The harmful effects of toxoplasmosis to pregnant women and immunocompromised patients have been delineated. Some of the disease manifestations include jaundice, rash, asphyxia, etc. The review traces the diagnostic work-up and comments on common tests for toxoplasmosis, such as taking of blood serum samples. The review ends with the treatment of the disease and of its ocular manifestations in particular, for example application of intravitreous injection. The prevention of the infection is extremely important for pregnant women, immunocompromised patients and patients with AIDS.

  9. Gene therapy in ocular diseases

    Directory of Open Access Journals (Sweden)

    Singh Vijay

    2002-01-01

    Full Text Available Gene therapy is a novel form of drug delivery that enlists the synthetic machinery of the patient′s cells to produce a therapeutic agent. Genes may be delivered into cells in vitro or in vivo utilising viral or non-viral vectors. Recent technical advances have led to the demonstration of the molecular basis of various ocular diseases. Ocular disorders with the greatest potential for benefit of gene therapy include hereditary diseases such as retinitis pigmentosa, tumours such as retinoblastoma or melanoma, and acquired proliferative and neovascular retinal disorders. Gene transfer into ocular tissues has been demonstrated with growing functional success and may develop into a new therapeutic tool for clinical ophthalmology in future.

  10. Cerebellum and Ocular Motor Control

    Directory of Open Access Journals (Sweden)

    Amir eKheradmand

    2011-09-01

    Full Text Available An intact cerebellum is a prerequisite for optimal ocular motor performance. The cerebellum fine-tunes each of the subtypes of eye movements so they work together to bring and maintain images of objects of interest on the fovea. Here we review the major aspects of the contribution of the cerebellum to ocular motor control. The approach will be based on structural-functional correlation, combining the effects of lesions and the results from physiologic studies, with the emphasis on the cerebellar regions known to be most closely related to ocular motor function: 1 the flocculus/paraflocculus for high-frequency (brief vestibular responses, sustained pursuit eye movements and gaze-holding, 2 the nodulus/ventral uvula for low-frequency (sustained vestibular responses, and 3 the dorsal oculomotor vermis and its target in the posterior portion of the fastigial nucleus (the fastigial oculomotor region for saccades and pursuit initiation.

  11. Ivermectin treatment of ocular onchocerciasis.

    Science.gov (United States)

    Taylor, H R

    1990-01-01

    Ivermectin, a recently developed macrocyclic lactone with broad antiparasitic activity, has been shown by a series of clinical trials to be safe and effective in the treatment of human infection with Onchocerca volvulus. Although it is rapidly microfilaricidal, it does not cause a severe reaction as is seen with diethylcarbamazine treatment. In patients with onchocerciasis, a single oral dose of ivermectin (150 micrograms/Kg) repeated once a year leads to a marked reduction in skin microfilaria counts and ocular involvement, although ivermectin has no known long-lasting effects on the adult worms. With treatment there is no significant exacerbation of either anterior or posterior segment eye disease even in those with severe ocular disease. Treatment leads to a marked and prolonged improvement in ocular status. Because of its safety and efficacy, ivermectin can be used on a mass scale and promises to revolutionize the treatment of onchocerciasis.

  12. The Ocular Surface Chemical Burns

    Directory of Open Access Journals (Sweden)

    Medi Eslani

    2014-01-01

    Full Text Available Ocular chemical burns are common and serious ocular emergencies that require immediate and intensive evaluation and care. The victims of such incidents are usually young, and therefore loss of vision and disfigurement could dramatically affect their lives. The clinical course can be divided into immediate, acute, early, and late reparative phases. The degree of limbal, corneal, and conjunctival involvement at the time of injury is critically associated with prognosis. The treatment starts with simple but vision saving steps and is continued with complicated surgical procedures later in the course of the disease. The goal of treatment is to restore the normal ocular surface anatomy and function. Limbal stem cell transplantation, amniotic membrane transplantation, and ultimately keratoprosthesis may be indicated depending on the patients’ needs.

  13. Clinical Study on Ocular Trauma in Children

    Institute of Scientific and Technical Information of China (English)

    Zicai Huang; Hongni Li; Yixia Huang; Zhongxia Zhou

    2002-01-01

    Purpose: To investigate the clinical characteristics of ocular trauma in children and put forward the major treatment and prevention of ocular trauma in children.Methods: To analyze the clinical data by 77 eyes in 77 cases of ocular trauma in children from April 1999 to February 2002. Results: The male and female were in the ratio of 2.21: 1. Right eye ocular traumas were more than left ones. Ocular penetrating trauma was 83.12% and blunt trauma 12.99%. 41 cases (53.25%) were injured by themselves while 33 cases by others. 90.91% patients came from the countryside.Conclusion: The rate of blindness of children with ocular trauma could be reduced by prompt treatment. The study indicated that ocular trauma preventive publicity should be faced in the countryside in order to improve the understanding of the severity of ocular trauma and treat it as a social problem.

  14. OCULAR FINDINGS IN CHILDREN WITH CEREBRAL PALSY ...

    African Journals Online (AJOL)

    ... with ocular abnormalities which often impact on their development and education. ... Age appropriate visual acuities were checked, ocular examination was done ... Cortical Visual Impairment (CVI) in 28(75.7%) subjects CVI, refractive errors ...

  15. Air bags and ocular injuries.

    Science.gov (United States)

    Stein, J D; Jaeger, E A; Jeffers, J B

    1999-01-01

    This investigation retrospectively examined ocular injuries associated with air bag deployment to gain a better appreciation of potential risk factors in motor vehicle accidents. National statistics regarding the efficacy of air bags were reviewed. Review of the literature from 1991 to 1998 identified 44 articles describing 97 patients with air-bag-induced ocular injuries. Variables extracted from each case were age, sex, height, position in the car, eye wear, vehicle impact speed, visual acuity, and specific ocular injuries. Corneal abrasions occurred in 49% of occupants, hyphemas in 43%, vitreous or retinal hemorrhages in 25%, and retinal tears or detachments in 15%. The globe was ruptured in 10 patients. Patients involved in higher-speed accidents (over 30 mph) sustained a greater percentage of vitreous or retinal hemorrhages and traumatic cataracts, while those at slower speeds were more prone to retinal tears or detachments. In a subset of 14 patients with serious ocular injuries, the impact speed of 11 patients was recorded at 30 mph or less. Slower speed may be a risk factor for some ocular injuries. Occupant height was not a significant factor. National statistics confirm that air bags reduce fatalities in motor vehicle accidents. However, children sitting in the front seat without a seat belt and infants in passenger-side rear-facing car seats are at risk for fatal injury. Air bags combined with seat belts are an effective means of reducing injury and death in adults during motor vehicle accidents. However, this study has documented a wide variety of ocular injuries associated with air bag deployment. It is hoped that researchers can develop modifications that continue to save lives while minimizing additional harm.

  16. Ocular rigidity, ocular pulse amplitude, and pulsatile ocular blood flow: the effect of intraocular pressure.

    Science.gov (United States)

    Dastiridou, Anna I; Ginis, Harilaos S; De Brouwere, Dirk; Tsilimbaris, Miltiadis K; Pallikaris, Ioannis G

    2009-12-01

    The purpose of this study was to characterize the pressure-volume relation in the living human eye, measure the ocular pulse amplitude (OPA), and calculate the corresponding pulsatile ocular blood flow (POBF) in a range of clinically relevant IOP levels. Fifty patients with cataract (50 eyes) were enrolled in the study. After cannulation of the anterior chamber, a computer-controlled device for the intraoperative measurement and control of IOP was used to artificially increase the IOP in a stepping procedure from 15 to 40 mm Hg. The IOP was continuously recorded for 2 seconds after each infusion step. The pressure-volume relation was approximated with an exponential fit, and the ocular rigidity coefficient was computed. OPA, pulse volume (PV), and POBF were measured from the continuous IOP recordings. The average rigidity coefficient was 0.0224 microL(-1) (SD 0.0049). OPA increased by 91% and PV and POBF decreased by 29% and 30%, respectively, when increasing the IOP from 15 to 40 mm Hg. The OPA is positively correlated with the coefficient of ocular rigidity (r = 0.65, P < 0.01). The present results suggest a nonlinear pressure-volume relation in the living human eye characterized by an increase in rigidity at higher IOP levels. The increased OPA and decreased pulse volume relate to the decreased POBF and the increased mechanical resistance of the ocular wall at high IOP levels.

  17. [Adverse ocular effects of vaccinations].

    Science.gov (United States)

    Ness, T; Hengel, H

    2016-07-01

    Vaccinations are very effective measures for prevention of infections but are also associated with a long list of possible side effects. Adverse ocular effects following vaccination have been rarely reported or considered to be related to vaccinations. Conjunctivitis is a frequent sequel of various vaccinations. Oculorespiratory syndrome and serum sickness syndrome are considered to be related to influenza vaccinations. The risk of reactivation or initiation of autoimmune diseases (e. g. uveitis) cannot be excluded but has not yet been proven. Overall the benefit of vaccination outweighs the possible but very low risk of ocular side effects.

  18. Iris mammillations in ocular melanocytosis.

    Science.gov (United States)

    Swann, Peter G

    2001-01-01

    Hyperpigmentation of the ocular tissues and of the skin around the eye is uncommon. In ocular melanosis, the episclera, uveal tract and the angle of the anterior chamber may be involved. Heterochromia iridis may be present, if the iris is affected. In oculodermal melanocytosis or the naevus of Ota, hyperpigmentation of the skin follows the distribution of the first and second divisions of the fifth cranial nerve. This report documents a patient with episcleral pigment, heterochromia iridis and numerous tiny pigmented nodules on the iris (mammillations). The possible significance of these findings is discussed.

  19. Ocular complications of orbital venography.

    Science.gov (United States)

    Safer, J N; Guibor, P

    1975-03-01

    Three ocular complications directly related to orbital venography are described, one resulting in permanent loss of vision,. The patient had lymphangioma of the orbit which evidently had bled secondary to increased venous pressure and injection of contrast bolus. Both of the 2 patients with transient visual disturbances had diabetic retinopathy. The common factor is felt to be an imparied vascular bed which cannot meet the stress of increased venous pressure and contrast medium injection. Conditions which predispose to ocular-orbital stasis and/or hemorrhage are discussed.

  20. Ocular complications of diabetes mellitus

    Institute of Scientific and Technical Information of China (English)

    Nihat Sayin; Necip Kara; Gokhan Pekel

    2015-01-01

    Diabetes mellitus (DM) is a important health problemthat induces ernestful complications and it causessignificant morbidity owing to specific microvascularcomplications such as, retinopathy, nephropathy andneuropathy, and macrovascular complications such as,ischaemic heart disease, and peripheral vasculopathy.It can affect children, young people and adults and isbecoming more common. Ocular complications associatedwith DM are progressive and rapidly becoming theworld's most significant cause of morbidity and arepreventable with early detection and timely treatment.This review provides an overview of five main ocularcomplications associated with DM, diabetic retinopathyand papillopathy, cataract, glaucoma, and ocular surfacediseases.

  1. Tumor ocular metastásico Metastatic ocular tumor

    Directory of Open Access Journals (Sweden)

    Martha G Domínguez Expósito

    2004-06-01

    Full Text Available El carcinoma metastásico del ojo es considerado la neoplasia maligna que más frecuente se encuentra de forma intraocular. Solo cerca del 10 % de las personas que tienen una o más lesiones metastásicas intraoculares son detectadas clínicamente antes de la muerte. A menudo, el carcinoma metastásico ocular es diagnosticado por el oftalmólogo ante la presencia de síntomas oculares. Las lesiones están localizadas con preferencia en coroides. Nos motivo a realizar la presentación de este caso la presencia de lesiones intraoculares múltiples tumorales metastásicos en un paciente cuyo síntoma de presentación fue la disminución de la agudeza visualThe eye metastatic carcinoma is considered the most frequently found intraocular malignant neoplasia. Only 10 % of the persons with one or more metastatic intraocular injuries are clinically detected before death. The metastatic ocular carcinoma is often diagnosed by the ophthalmologist in the presence of ocular symptoms. The injuries are preferably located in the choroid. The appearance of multiple metastatic intraaocular tumoral injuries in a patient whose chief complaint was the reduction of visual acuity motivated us to presente this case

  2. Follicular lymphoma of the ocular adnexal region

    DEFF Research Database (Denmark)

    Rasmussen, Peter Kristian; Ralfkiaer, E.; Prause, J.U.

    2015-01-01

    with ocular adnexal follicular lymphoma were identified. Fourteen (58%) of the patients were females. The median age was 63 years (range: 42–96 years). Eleven (46%) of the patients had primary ocular adnexal lymphoma, seven (29%) had an ocular adnexal lesion in conjunction with a concurrent systemic lymphoma...

  3. Search for extra space dimensions with ATLAS

    Indian Academy of Sciences (India)

    Ambreesh Gupta; ATLAS Collaboration

    2004-03-01

    If extra spatial dimensions were to exist, they could provide a solution to the hierarchy problem. The studies done by the ATLAS Collaboration on the sensitivity of the detector to various extra dimension models are reported in this document.

  4. Extraocular muscle dynamics in diplopia from enophthalmos.

    Science.gov (United States)

    Yoon, Michael K; Economides, John R; Horton, Jonathan C

    2011-12-01

    The mechanism of diplopia from enophthalmos is not well understood. We describe a 55-year-old man who underwent a left transorbital craniotomy for clipping of a basilar aneurysm. The lateral orbital wall was not reconstructed properly, resulting in 8 mm of left enophthalmos. Months after surgery the patient developed diplopia with ocular excursions, although he remained orthotropic in primary gaze. The left eye was limited in elevation, adduction, and abduction. These findings were confirmed by eye movement recordings, which showed ocular separation increasing with gaze eccentricity. A CT scan demonstrated a defect in the sphenoid and frontal bones, profound enophthalmos, and shortening of the rectus muscles. Slack in the extraocular muscles reduced the force generated by each muscle, causing diplopia with ocular rotation. This case underscores the value of careful orbital wall reconstruction after orbitotomy and suggests a mechanism for diplopia produced by postoperative enophthalmos.

  5. Ocular rigidity, ocular pulse amplitude, and pulsatile ocular blood flow: the effect of axial length.

    Science.gov (United States)

    Dastiridou, Anna I; Ginis, Harilaos; Tsilimbaris, Miltiadis; Karyotakis, Nikos; Detorakis, Efstathios; Siganos, Charalambos; Cholevas, Pierros; Tsironi, Evangelia E; Pallikaris, Ioannis G

    2013-03-01

    Previous studies have shown a negative correlation between axial length (AL) and pulsatile ocular blood flow (POBF). This relation has been questioned because of the possible confounding effect of ocular volume on ocular rigidity (OR). The purpose of this study was to investigate the relation between AL, as a surrogate parameter for ocular volume, and OR, ocular pulse amplitude (OPA), and POBF. Eighty-eight cataract patients were enrolled in this study. A computer-controlled device comprising a microdosimetric pump and a pressure sensor was used intraoperatively. The system was connected to the anterior chamber and used to raise the intraocular pressure (IOP) from 15 to 40 mm Hg, by infusing the eye with a saline solution. After each infusion step, the IOP was continuously recorded for 2 seconds. Blood pressure and pulse rate were measured during the procedure. The OR coefficient was calculated from the pressure volume data. OPA and POBF were measured from pressure recordings. Median AL was 23.69 (interquartile range 3.53) mm. OR coefficient was 0.0218 (0.0053) μL(-1). A negative correlation between the OR coefficient and AL (ρ = -0.641, P < 0.001) was documented. Increasing AL was associated with decreased OPA (ρ = -0.637, P < 0.001 and ρ = -0.690, P < 0.001) and POBF (ρ = -0.207, P = 0.053 and ρ = -0.238, P = 0.028) at baseline and elevated IOP, respectively. Based on manometric data, increasing AL is associated with decreased OR, OPA, and POBF. These results suggest decreased pulsatility in high myopia and may have implications on ocular pulse studies and the pathophysiology of myopia.

  6. Ocular Toxoplasmosis: Lessons from Brazil

    Science.gov (United States)

    • A new attention to post-natally acquired infections. Previously, most attention was focused on infection during pregnancy, and the risk of congenital disease, with the feeling that infection in older individuals was benign, without a substantial risk of disease morbidity, such as ocular involvemen...

  7. Ocular toxoplasmosis associated with scleritis

    Directory of Open Access Journals (Sweden)

    Yogish S Kamath

    2013-01-01

    Full Text Available We report an atypical presentation of Toxoplasma retinochoroiditis with associated scleritis in a young and immunocompetent patient. The diagnosis was done on the basis of Polymerase chain reaction of vitreous sample, and the clinical response to specific treatment. This case highlights the unusual presentation of ocular toxoplasmosis as scleritis.

  8. Imaging the ocular motor nerves.

    NARCIS (Netherlands)

    Ferreira, T.; Verbist, B.M.; Buchem, M. van; Osch, T. van; Webb, A.

    2010-01-01

    The ocular motor nerves (OMNs) comprise the oculomotor, trochlear and the abducens nerves. According to their course, they are divided into four or five anatomic segments: intra-axial, cisternal, cavernous and intra-orbital and, for the abducens nerve, an additional interdural segment. Magnetic reso

  9. Chlorpromazine induced ocular myasthenia gravis

    Directory of Open Access Journals (Sweden)

    Nitya S

    2013-10-01

    Full Text Available Drug induced bilateral ptosis is a very rare adverse drug reaction. Here we report a case of ten year old male child with chlorpromazine induced bilateral ptosis due to ocular myasthenia. [Int J Basic Clin Pharmacol 2013; 2(5.000: 653-654

  10. Therapeutical Management for Ocular Rosacea

    Directory of Open Access Journals (Sweden)

    Gloria López-Valverde

    2016-05-01

    Full Text Available Purpose: The purpose of this study is to describe a case of ocular rosacea with a very complex evolution. Rosacea is a chronic dermatological disease that may affect the ocular structures up to 6-72% of all cases. This form is often misdiagnosed, which may lead to long inflammatory processes with important visual consequences for affected patients. Therefore, an early diagnosis and an adequate treatment are important. Methods: We report the case of a 43-year-old patient who had several relapses of what seemed an episode of acute bacterial conjunctivitis. Two weeks later, he developed a corneal ulcer with a torpid evolution including abundant intrastromal infiltrators and calcium deposits. He was diagnosed with ocular rosacea and treated with systemic doxycycline and topical protopic. Results: A coating with amniotic membrane was placed in order to heal the ulcer, but a deep anterior lamellar keratoplasty to restore the patient’s vision because of the corneal transparency loss was necessary. Conclusions: Ocular rosacea includes multiple ophthalmic manifestations ranging from inflammation of the eyelid margin and blepharitis to serious corneal affectations. A delayed diagnosis can result in chronic inflammatory conditions including keratinization and loss of corneal transparency, which lead to important visual sequelae for affected patients.

  11. Magnetic resonance imaging of the extraocular muscles and corresponding cranial nerves in patients with special forms of strabismus

    Institute of Scientific and Technical Information of China (English)

    JIAO Yong-hong; ZHAO Kan-xing; WANG Zhen-chang; QIAN Xue-han; WU Xiao; MAN Feng-yuan; LU Wei; SHE Hai-cheng

    2009-01-01

    Background With the technical advances, magnetic resonance imaging (MRI) is now sensitive enough to detect subtle structural abnormalities of ocular motor nerves arising from the brainstem and orbits of living subjects. This study was designed to delineate the MRI characteristics in patients with special forms of strabismus.Methods A total of 29 patients with special forms of strabismus underwent orbital and intracalvarium MRI. Imaging of the ocular motor nerves in the brainstem was performed in 0.8 mm thickness image planes using the three-dimensional fast imaging employing steady-state acquisition (3D-FIESTA) sequence. Nerves to extraocular muscles (EOMs), EOMs and their associated connective tissues were imaged with T1 weighting in tri-planar scans by dual-phased coils within 2.0 mm thick planes.Results Patients with congenital fibrosis of the extraocular muscles exhibited hypoplasia of the oculomotor (CN3), abducens (CN6), trochlear (CN4) nerves, and the EOMs; hypoplasia of CN6 in the brainstem and an extra branch of the inferior division of CN3 to the lateral rectus were the most common but not the only presentation of Duane's retraction syndrome. Hypoplasia of CN6, facial (CN7) and hypoglossal (CN12) nerves were revealed in patients with M(o)bius syndrome. In a rare case of bilateral synergistic convergence and divergence, an enlarged branch of CN3 to the medial rectus and a questionable branch of CN3 to the inferior rectus bilaterally were found.Conclusion MRI can reveal subtle structures of the ocular motor nerves and their corresponding EOMs. This can provide valuable information regarding pathogenesis in some special forms of strabismus.

  12. Topical ocular delivery of fluoroquinolones.

    Science.gov (United States)

    Pawar, Pravin; Katara, Rajesh; Mishra, Sushil; Majumdar, Dipak K

    2013-05-01

    Topical fluoroquinolones are used in ophthalmology to treat ocular infections. They are bactericidal and inhibit bacterial DNA replication by inhibiting DNA gyrase and topoisomerase. Fluoroquinolones possess two ionizable groups: a carboxylic group (pKa1 = 5.5 - 6.34) and a heterocyclic group (pKa2 = 7.6 - 9.3), in the nucleus, which acquire charge at pH above and below the isoelectric point (pI = 6.75 - 7.78). At isoelectric point, fluoroquinolones remain unionized and show enhanced corneal penetration but exhibit reduced aqueous solubility and the drug may precipitate from aqueous solution. Aqueous ophthalmic solutions of fluoroquinolones are obtained by using hydrochloride or mesylate salt which is acidic and irritating to the eyes. Hence, pH of the solution is kept between 5 and 7 to ensure aqueous solubility and minimum ocular irritation. This review gives an overview of various physicochemical and formulation factors affecting the ocular delivery of fluoroquinolones and strategies for getting higher ocular bioavailability for ocular delivery of fluoroquinolones. These strategies could be employed to improve efficacy of fluoroquinolones in eye preparation. Broad-spectrum antibacterials, such as the ophthalmic fluoroquinolones, are powerful weapons for treating and preventing potentially sight-threatening infections. The fourth-generation fluoroquinolones have quickly assumed an outstanding place in the ophthalmic applications. Especially valuable for their broad-spectrum coverage against Gram-positive and Gram-negative organisms, these agents have become the anti-infective of preference for many ophthalmologists. Moxifloxacin seems to be a promising powerful molecule among all fluoroquinolones for treatment of bacterial infections.

  13. Light Stops from extra dimensions

    CERN Document Server

    Garcia-Pepin, Mateo

    2016-01-01

    In supersymmetric models the mass of the stops can be considered as the naturalness measure of the theory. Roughly, the lighter the stops are, the more natural the theory is. Both, the absence of supersymmetric signals at experiment and the measurement of the Higgs mass, put scenarios with light stops under increasing tension. I will present a supersymmetry breaking mechanism of the Scherk-Schwarz type that, by introducing extra $SU(2)_L$ triplets in the Higgs sector, is able to generate the correct Higgs mass while keeping stops light.

  14. Toxicidad ocular medicamentosa Ocular toxicity induced by medication

    Directory of Open Access Journals (Sweden)

    A. Garralda

    2008-01-01

    Full Text Available En el presente trabajo se analiza la toxicidad ocular inducida por cuatro grupos de fármacos sistémicos: tamoxifeno, cloroquina y derivados, anticolinérgicos y tamsulosina. El objetivo principal es dar unas normas prácticas que sirvan para el manejo diario de los pacientes sometidos a estos tratamientos, más que profundizar en los mecanismos de acción de cada uno de ellos.This paper analyses ocular toxicity induced by four groups of systemic medicines: tamoxifen, chloroquine and derivatives, anticholinergics and tamsulosin. Our main aim is to provide some practical rules that will be of use in the everyday management of patients receiving these treatments, rather than to examine the mechanisms by which each of these medicines act.

  15. Higgs Bosons in Extra Dimensions

    CERN Document Server

    Quiros, Mariano

    2015-01-01

    In this paper, motivated by the recent discovery of a Higgs-like boson at the LHC with a mass m_H\\simeq 126 GeV, we review different models where the hierarchy problem is solved by means of a warped extra dimension. In the Randall-Sundrum model electroweak observables provide very strong bounds on the mass of KK modes which motivates extensions to overcome this problem. Two extensions are briefly discussed. One particular extension is based on the deformation of the metric such that it strongly departs from the AdS_5 structure in the IR region while it goes asymptotically to AdS_5 in the UV brane. This model has the IR brane close to a naked metric singularity (which is outside the physical interval) characteristic of soft-walls constructions. The proximity of the singularity provides a strong wave-function renormalization for the Higgs field which suppresses the T and S parameters. The second class of considered extensions are based on the introduction of an extra gauge group in the bulk such that the custod...

  16. Estudo sobre a aplicabilidade de adesivos biológicos à reinserção de músculo ocular externo em coelhos - I Experimento I - Medidas dos tempos dos procedimentos, das forças de adesão mioescleral e estudos clínico e histopatológico A study of the applicability of biological adhesives to the reinsertion of an external ocular muscle in rabbits - I Experiment I - Measurements of duration of procedures, and clinical and histopathologic studies

    Directory of Open Access Journals (Sweden)

    Beatriz Simões Corrêa

    2005-10-01

    Full Text Available OBJETIVO: Medir o tempo da operação, as forças de adesão tecidual e fazer estudo clínico e histopatológico de reinserções oculares de retos superiores de coelho com quatro diferentes adesivos teciduais, como alternativa à utilização de sutura de poliglactina em operações de estrabismo. MÉTODOS: Cem coelhos da raça Nova Zelândia foram distribuídos em dois experimentos, I-A e I-B, de cinqüenta coelhos cada, e estes em cinco grupos de dez coelhos (vinte olhos, submetidos à operação de desinserção do músculo reto superior de ambos os olhos, e reinserção com sutura (controle com poliglactina 910, 6-0 ou adesivos teciduais, de fibrina, cianoacrilato, albumina-glutaraldeído e gelatina-resorcinol-formaldeído-glutaraldeído. Os coelhos do experimento I-A foram submetidos à dinamometria nos dez minutos após o reposicionamento muscular. Os coelhos do experimento I-B foram submetidos à avaliação clínica e histopatológica. RESULTADOS: Verificou-se melhor desempenho dos adesivos teciduais no tempo gasto para realizar a operação. Quanto à força de adesão, nenhum dos adesivos apresentou 100% de casos com resistência à tensão igual ou maior que 100 gf. Com relação às avaliações clínica e histopatológica, quanto à presença dos sinais inflamatórios e suas intensidades o adesivo fibrínico utilizado neste trabalho apresentou melhor desempenho do que a sutura de poliglactina 910, tendo os demais adesivos apresentado resultados piores, quando comparados aos do grupo controle (sutura. CONCLUSÃO: Os adesivos estudados mostraram-se inadequados para as operações de estrabismo.PURPOSE: To measure the duration of the operation, the strength of tissue adhesion, and to perform a clinical and histopathological study of ocular reinsertion of superior rectus muscles of rabbits with four different tissue adhesives, as an alternative to the use of polyglactin suture in strabismus surgeries. METHODS: One hundred New Zealand

  17. An Adult Patient with Ocular Myasthenia and Unusually Long Spontaneous Remission

    Directory of Open Access Journals (Sweden)

    Jasem Al-Hashel

    2014-01-01

    Full Text Available A male patient developed ocular myasthenia gravis (MG at the age of 33. He was anti-acetylcholine receptor antibody (anti-AChR Ab negative. He received cholinesterase blocker for 5 months and went into a complete clinical remission that lasted untreated for 17 years. He relapsed recently with ocular symptoms only. He is now anti-AChR Ab positive and SFEMG is abnormal in a facial muscle. The patient is controlled with steroids. He had one of the longest spontaneous remissions reported in the natural history of MG, particularly unusual for an adult with the disease.

  18. [Ocular toxocariasis--case report].

    Science.gov (United States)

    Moraru, Andreea; Panfil, Madălina; Totolici, Geanina; Brănişteanu, Daniel; Costin, Dănut; Schmitzer, Speranţa

    2014-01-01

    Ocular Toxocariasis is a parasitosis caused by Toxocara catis/canis larvae localized in the eye. The most frequent clinical manifestations are the central retinal granuloma, peripheral retinal granuloma and chronic endophthalmitis. Secondary complications due to the presence of parasite in the posterior segment of the eye may have significant consequences on visual function. We present the case of a 23 years old patient, admitted for progressive decrease of the right eye BCVA during the last 6 months. After performing clinical examination and serological tests we established the diagnosis of ocular Toxocariasis. The patient presented a particular form of the disease consisting in the presence of both a central retinal granuloma and a peripheral one. We performed 23G pars plana vitrectomy and membrane peeling. VA improved as soon as the first month after surgery.

  19. Ocular Surface Reconstruction: Recent Innovations

    Directory of Open Access Journals (Sweden)

    Madhavan HN

    2009-01-01

    Full Text Available The ocular surface is exceptionally rich in complexity and functionality. Severe ocular surface disorders/conditions, such as chemical or thermal injuries, Stevens-Johnson syndrome (SJS, ocular cicatricial pemphigoid, neurotrophic keratopathy, chronic limbitis, and severe microbial keratitis cause significant morbidities and even corneal blindness. Hypofunction may be caused by Aniridia, Neurotrophy, Endocrine, Pterygium and Chronic limbitis Approximately 6000 patients are seen in Ocular Surface Clinic every year; almost 80% have some form of dry eyes. About 125 new patients of Stevens Johnson Syndrome are seen in a year of which approximately 25% may benefit from Cultured Epithelial Transplant and 75 new patients of thermal/chemical injury in a year of which almost 80% will benefit from Stem Cell Transplantation. Of the 128 severe vernal keratoconjunctivitis which were seen in the ocular surface clinic, 10% require stem cell transplantation. Nearly 30 new cases of Ocular cicatrical pemphigoid every year are seen and they may need stem cell transplantation. In addition, several patients with persistent epithelial defects may benefit from limbal stem cell transplantation to alleviate, maintain conjunctivalization regression and corneal avascularity limbal deficiency, and restore vision. Even if granted that this statistics is for a single large ophthalmic hospital, for a large country as India with 1.1 billion populations, the number of patients requiring corneal stem cell transplantation is enormous. Stem cells in the palisades of Vogt participate in regeneration and preservation of corneal transparency and avascularity. The diminished regenerative capacity seen in LSCD is characterized by persistent epithelial defects, erosion and ulceration, conjunctivalization and neovascularization, and chronic inflammation. Standard corneal transplantation for restoration of corneal clarity and avascularity is a contraindication in the surgical management

  20. Tuberculose ocular: relato de casos

    Directory of Open Access Journals (Sweden)

    Costa Daniella Socci da

    2003-01-01

    Full Text Available Os autores relatam dois casos de tuberculose ocular presumida com comprometimento coroidiano. No primeiro caso, um paciente de 43 anos, HIV positivo, com tuberculose pulmonar miliar e tuberculoma cerebral, apresenta um granuloma coroidiano único na região macular do olho esquerdo. No segundo caso, uma paciente de 12 anos, HIV negativa, com tuberculose pulmonar apresenta coroidite multifocal e comprometimento do segmento anterior do olho esquerdo. Ambos os pacientes evoluíram favoravelmente com o tratamento específico, apresentando completa resolução das lesões. As lesões oculares da tuberculose são diversas e devemos continuar atentos a esta enfermidade.

  1. Ocular effects of radiofrequency energy.

    Science.gov (United States)

    Elder, J A

    2003-01-01

    Radiofrequency (RF) energy has been reported to cause a variety of ocular effects, primarily cataracts but also effects on the retina, cornea, and other ocular systems. Cataracts have been observed in experimental animals when one eye was exposed to a localized, very high RF field and the other eye was the unexposed control. The results show that 2450 MHz exposures for >or=30 min at power densities causing extremely high dose rates (>or=150 W/kg) and temperatures (>or=41 degrees C) in or near the lens caused cataracts in the rabbit eye. However, cataracts were not observed in the monkey eye exposed to similar exposure conditions, reflecting the different patterns of energy absorption (SAR, specific absorption rate) distribution, due to their different facial structure. Since the monkey head is similar in structure to the human head, the nonhuman primate study showed that the incident power density levels causing cataracts in rabbits and other laboratory animals cannot be directly extrapolated to primates, including human beings. It is reasonable to assume that an SAR that would induce temperatures >or=41 degrees C in or near the lens in the human eye would produce cataracts by the same mechanism (heating) that caused cataracts in the rabbit lens; however, such an exposure would greatly exceed the currently allowable limits for human exposure and would be expected to cause unacceptable effects in other parts of the eye and face. Other ocular effects including corneal lesions, retinal effects, and changes in vascular permeability, have been observed after localized exposure of the eye of laboratory animals to both continuous wave (CW) and pulsed wave (PW) exposures, but the inconsistencies in these results, the failure to independently confirm corneal lesions after CW exposure, the failure to independently confirm retinal effects after PW exposure, and the absence of functional changes in vision are reasons why these ocular effects are not useful in defining an

  2. Ocular concentrations of mitomycin C using different delivery devices.

    Science.gov (United States)

    Mietz, H; Diestelhorst, M; Rump, A F; Theisohn, M; Klaus, W; Krieglstein, G K

    1998-01-01

    Hypotony and its sequelae are a frequent complication of trabeculectomies performed with mitomycin C (MMC), possibly related to intraocular toxicity of the substance. In an animal model with rabbits, we used different devices for the application of MMC and measured extra- and intraocular concentrations by HPLC. In addition, the concentrations of MMC remaining in the devices were determined. The devices were (1) a regular surgical sponge, (2) a scleral shield, (3) a presoaked soft contact lens, (4) a soft contact lens with MMC application, and (5) subconjunctival injection. Ocular concentrations of MMC were similar within the first 4 groups and were highest in the last. The measurements suggest that MMC penetrates intraocularly regardless of the device used. The variability of remaining MMC concentrations in the devices was lowest in the soft contact lenses suggesting an improved delivery system compared to the usually used surgical sponges.

  3. Topical ocular delivery of NSAIDs.

    Science.gov (United States)

    Ahuja, Munish; Dhake, Avinash S; Sharma, Surendra K; Majumdar, Dipak K

    2008-06-01

    In ocular tissue, arachidonic acid is metabolized by cyclooxygenase to prostaglandins which are the most important lipid derived mediators of inflammation. Presently nonsteroidal anti-inflammatory drugs (NSAIDs) which are cyclooxygenase (COX) inhibitors are being used for the treatment of inflammatory disorders. NSAIDs used in ophthalmology, topically, are salicylic-, indole acetic-, aryl acetic-, aryl propionic- and enolic acid derivatives. NSAIDs are weak acids with pKa mostly between 3.5 and 4.5, and are poorly soluble in water. Aqueous ophthalmic solutions of NSAIDs have been made using sodium, potassium, tromethamine and lysine salts or complexing with cyclodextrins/solubilizer. Ocular penetration of NSAID demands an acidic ophthalmic solution where cyclodextrin could prevent precipitation of drug and minimize its ocular irritation potential. The incompatibility of NSAID with benzalkonium chloride is avoided by using polysorbate 80, cyclodextrins or tromethamine. Lysine salts and alpha-tocopheryl polyethylene glycol succinate disrupt corneal integrity, and their use requires caution. Thus a nonirritating ophthalmic solution of NSAID could be formulated by dissolving an appropriate water-soluble salt, in the presence of cyclodextrin or tromethamine (if needed) in mildly acidified purified water (if stability permits) with or without benzalkonium chloride and polyvinyl alcohol. Amide prodrugs met with mixed success due to incomplete intraocular hydrolysis. Suspension and ocular inserts appear irritating to the inflamed eye. Oil drop may be a suitable option for insoluble drugs and ointment may be used for sustained effect. Recent studies showed that the use of colloidal nanoparticle formulations and the potent COX 2 inhibitor bromfenac may enhance NSAID efficacy in eye preparations.

  4. Topical Ocular Delivery of NSAIDs

    OpenAIRE

    Ahuja, Munish; Avinash S Dhake; Sharma, Surendra K; Dipak K Majumdar

    2008-01-01

    In ocular tissue, arachidonic acid is metabolized by cyclooxygenase to prostaglandins which are the most important lipid derived mediators of inflammation. Presently nonsteroidal anti-inflammatory drugs (NSAIDs) which are cyclooxygenase (COX) inhibitors are being used for the treatment of inflammatory disorders. NSAIDs used in ophthalmology, topically, are salicylic-, indole acetic-, aryl acetic-, aryl propionic- and enolic acid derivatives. NSAIDs are weak acids with pKa mostly between 3.5 a...

  5. Ocular dirofilariasis in Dubai, UAE.

    Science.gov (United States)

    Mittal, Mamta; Sathish, K R; Bhatia, Prashant G; Chidamber, B S

    2008-01-01

    A rare occurrence of ocular subconjunctival dirofilariasis in a 53-year-old healthy Indian male working in Dubai, UAE presenting with an acute red eye is reported. Surgical excision under topical anesthesia was carried out uneventfully in the outpatient clinic. The live worm removed from the subconjunctival space was identified as Dirofilaria repens on the basis of microscopic examination and histopathology. Surgical excision of subconjunctival dirofilariasis is safe in an outpatient setting and curative precluding the need for further systemic antihelminthics.

  6. Opportunistic ocular infections in AIDS

    Institute of Scientific and Technical Information of China (English)

    Shikha Baisakhiya DOMS; FGO

    2008-01-01

    As the number of HIV infected patients is multiplying exponentially day by day so are the associated ocular complications.The increasing longevity of individuals with HIV disease has resulted in greater numbers of pa-tients with ocular opportunistic infection.By the means of this article we describe various opportunistic ocular infections in AIDS and their clinical manifestations,discussed under four headings;1 )adnexal manifestation;2)anterior segment manifestation;3)posterior segment manifestation;4)neuro ophthalmic manifestation . Herpes zoster ophthalmicus,molluscum contagiosum and Kaposi sarcoma are common adnexal manifestations. Molluscum contagiosum being the commonest.Varicella Zoster Virus (VZV)and herpes simplex virus (HSV) most commonly cause infectious keratitis in HIV-positive patients .As compared to the immunocompetent indi-viduals the frequency of bacterial and fungal keratitis is not more in HIV patients,but it tends to be more se-vere.Posterior segment structures involved in HIV-positive patients include the retina,choroid,and optic nerve head.The herpesvirus family is implicated most commonly in infections of the retina and choroid in HIV positive patients.CMV is the most common cause of retinitis and the commonest intraocular infection in AIDS. Atypical presentations resistance to conventional treatment and higher rate of recurrence make the diagnosis and therapeutic intervention more difficult and challenging.In addition,in one eye,several infections may occur at the same time,rendering the situation more difficult.

  7. Flavor Symmetries in Extra Dimensions

    CERN Document Server

    Aranda, A; Aranda, Alfredo

    2002-01-01

    We present a model of flavor based on a discrete local symmetry that reproduces all fermion masses and mixing angles both in the quark and lepton sectors. The particle content of the model is that of the standard model plus an additional flavon field. All the fields propagate in a fifth universal extra dimension and the flavor scale is associated with the cutoff of the 5D theory which is $\\sim 10$ TeV. The Yukawa matrices as well as the Majorana mass matrix for the neutrinos are generated by higher dimension operators involving the flavon field. When the flavon field acquires a vacuum expectation value it breaks the flavor symmetry and thus generates the Yukawa couplings. The model is consistent with the nearly bimaximal solution to the solar and atmospheric neutrino deficits.

  8. Materia extraña

    CERN Document Server

    Gómez Cadenas, J J

    2008-01-01

    Enero, 1999. Unas extrañas burbujas se han colocado en el acelerador de particulas del CERN (Ginebra). Ante el riesgo de que esto desencadene una catástrofe a escala mundial, el centro ordena detener el experimento. Años después, Irene, una joven y promotedora científica, es contratada en la división de Física Teórica del CERN. Allí coincide con el mayor Espinosa, destinado a la sede suiza de la ONU para trabajar en un proyecto contra la proliferación de armas nucleares. La misión de Espinosa resulta ser mucho más arriesgada de lo que parecía. Irene ambiciosa y rebelde, toma una decisión de efectos imprevisibles.

  9. Transplant related ocular surface disorders: Advanced techniques for ocular surface rehabilitation after ocular complications secondary to hematopoietic stem cell transplantation.

    Science.gov (United States)

    Stahl, Erin D; Mahomed, Faheem; Hans, Amneet K; Dalal, Jignesh D

    2016-05-01

    HSCT has been linked to the development of an assortment of ocular surface complications with the potential to lead to permanent visual impairment if left untreated or if not treated early in the course of disease. Strategies for therapy include maintenance of lubrication and tear preservation, prevention of evaporation, decreasing inflammation, and providing epithelial support. The ultimate aim of treatment is to prevent permanent ocular sequelae through prompt ophthalmology consultation and the use of advanced techniques for ocular surface rehabilitation. We describe several rehabilitation options of ocular surface complications occurring secondarily during the post-HSCT course.

  10. Three-dimensional interactive and stereotactic atlas of head muscles and glands correlated with cranial nerves and surface and sectional neuroanatomy.

    Science.gov (United States)

    Nowinski, Wieslaw L; Chua, Beng Choon; Johnson, Aleksandra; Qian, Guoyu; Poh, Lan Eng; Yi, Su Hnin Wut; Bivi, Aminah; Nowinska, Natalia G

    2013-04-30

    Three-dimensional (3D) relationships between head muscles and cranial nerves innervating them are complicated. Existing sources present these relationships in illustrations, radiologic scans, or autopsy photographs, which are limited for learning and use. Developed electronic atlases are limited in content, quality, functionality, and/or presentation. We create a truly 3D interactive, stereotactic and high quality atlas, which provides spatial relationships among head muscles, glands and cranial nerves, and correlates them to surface and sectional neuroanatomy. The head muscles and glands were created from a 3T scan by contouring them and generating 3D models. They were named and structured according to Terminologia anatomica. The muscles were divided into: extra-ocular, facial, masticatory and other muscles, and glands into mouth and other glands. The muscles, glands (and also head) were placed in a stereotactic coordinate system. This content was integrated with cranial nerves and neuroanatomy created earlier. To explore this complex content, a scalable user interface was designed with 12 modules including central nervous system (cerebrum, cerebellum, brainstem, spinal cord), cranial nerves, muscles, glands, arterial system, venous system, tracts, deep gray nuclei, ventricles, white matter, visual system, head. Anatomy exploration operations include compositing/decompositing, individual/group selection, 3D view-index mapping, 3D labeling, highlighting, distance measuring, 3D brain cutting, and axial/coronal/sagittal triplanar display. To our best knowledge, this is the first truly 3D, stereotactic, interactive, fairly complete atlas of head muscles, and the first attempt to create a 3D stereotactic atlas of glands. Its use ranges from education of students and patients to research to potential clinical applications.

  11. Método para el estudio de los movimientos oculares.

    Directory of Open Access Journals (Sweden)

    Mario Alfredo Parra

    2009-11-01

    Full Text Available Introducción: El análisis cuantitativo de los movimientos oculares en el dominio digital ha permitido incrementar la cantidad de información fisiológica que se puede extraer durante la interpretación de las señales oculográficas. En el terreno de las neurociencias, esto posibilita profundizar en el estudio de los mecanismos fisiopatológicos responsables de las afecciones oculomotoras. Objetivos: La finalidad de estos métodos de análisis es reducir el componente subjetivo que se introduce durante la clasificación visual de registros de actividad eléctrica, reduciendo además la experiencia requerida para hacer una correcta evaluación de patrones funcionales. Material y métodos: En el presente trabajo, se estudió la respuesta de persecución visual en 27 sujetos normales aplicando métodos de análisis cuantitativo tanto en el dominio del tiempo como en el dominio de la frecuencia. Se determinó un conjunto de variables que actúa como descriptores cuantitativos de la ejecución oculomotora durante tareas que activan al sistema motor ocular. Resultados: Demuestran que las variables estudiadas en ambos dominios pueden ser de gran utilidad para incrementar el conocimiento de los mecanismos subyacentes a la ejecución oculomotora. La cantidad de información extraída por estos métodos, supera 80% del total de la posible a extraer. Conclusiones: Se deben dirigir estudios posteriores para evaluar el comportamiento de estas variables en afecciones del sistema nervioso donde el sistema motor ocular muestre algún grado de compromiso funcional.

  12. Impact of Microbiome on Ocular Health.

    Science.gov (United States)

    Kugadas, Abirami; Gadjeva, Mihaela

    2016-07-01

    The ocular surface is continuously exposed to the environment and, therefore, it is surprising that it harbors only few commensals with low degree of diversity. This unique aspect of the ocular surface physiology prompts the question whether there are core ocular commensal communities and how they affect ocular immunity. The purpose of this review is to provide an overview of what is known about the ocular surface commensals in health and disease and what we would like to learn in the near future. In addition, we discuss how microbiota at sites other than the eye may influence ocular immune responses. The information discussed in the review has been gathered using PubMed searches for literature published from January 1982 to December 2015. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Exploring Extra Dimensions in Spectroscopy Experiments

    Institute of Scientific and Technical Information of China (English)

    LUO Feng; LIU Hong-Ya

    2006-01-01

    @@ We propose an idea in spectroscopy to search for extra spatial dimensions as well as to detect the possible deviation from Newton's inverse-square law at small scale, and we take high-Z hydrogenic systems and muonic atoms as illustrations. The relevant experiments might help to explore a more than two extra dimensions scenario in the brane world model proposed by Arkani-Hamed, Dimopoulos, Dvali (ADD) and to set constraints for fundamental parameters such as the size of extra dimensions.

  14. OCULAR INFECTIONS: RATIONAL APPROACH TO ANTIBIOTIC THERAPY

    OpenAIRE

    Mulla Summaiya A; Khokhar Neeta D; Revdiwala Sangita B

    2012-01-01

    Background: Isolation of common pathogens involved in ocular infection and their in-vitro susceptibility to commonly used ocular antibiotics, as well as the trends in antibiotic resistance developed by these pathogens were investigated. Material/Methods: All patients with suspected bacterial ocular infections presenting between march 2010 and feb 2011 were examined under slit lamp microscope and samples were collected by using aseptic techniques. All samples were processed for direct microsco...

  15. Ocular Blood Flow Autoregulation Mechanisms and Methods

    OpenAIRE

    Xue Luo; Yu-meng Shen; Meng-nan Jiang; Xiang-feng Lou; Yin Shen

    2015-01-01

    The main function of ocular blood flow is to supply sufficient oxygen and nutrients to the eye. Local blood vessels resistance regulates overall blood distribution to the eye and can vary rapidly over time depending on ocular need. Under normal conditions, the relation between blood flow and perfusion pressure in the eye is autoregulated. Basically, autoregulation is a capacity to maintain a relatively constant level of blood flow in the presence of changes in ocular perfusion pressure and va...

  16. Innate immunity of the ocular surface.

    Science.gov (United States)

    Ueta, Mayumi; Kinoshita, Shigeru

    2010-02-15

    The ocular surface epithelium serves a critical function as the defensive front line of the innate immune system. While the detection of microbes is arguably its most important task, an exaggerated host defense reaction to endogenous bacterial flora may initiate and perpetuate inflammatory mucosal responses. The ability of cells to recognize pathogen-associated molecular patterns (PAMPs) mainly depends on the expression of a family of Toll-like receptors (TLRs). A healthy ocular surface is not inflammatory, even though ocular surface epithelium is in constant contact with bacteria and bacterial products. In this study, we show that human ocular surface epithelial cells, both corneal and conjuctival epithelial cells, respond to viral double-stranded RNA mimic polyI:C to produce pro-inflammatory cytokines through TLR3, while they fail to respond functionally to lipopolysaccharide, a TLR4 ligand. Moreover, human ocular surface epithelium responds to flagellins from ocular pathogenic, but not ocular non-pathogenic bacteria, to produce pro-inflammatory cytokines through TLR5. Thus, ocular surface epithelial cells selectively respond to microbial components and induce limited inflammation; immune-competent cells can recognize microbial components through TLRs and induce the inflammation. The unique innate immune response of the ocular surface epithelium may contribute to its coexistence with commensal bacteria. Inflammatory bowel disease is thought to result from an abnormal response to the gut microbiota. Thus, we also considered the possibility of an association between ocular surface inflammation and a disordered innate immune response. IkappaBzeta is important for TLR signaling, in mice, its knock-out produced severe, spontaneous ocular surface inflammation, the eventual loss of goblet cells, and spontaneous perioral inflammation, suggesting that dysfunction/abnormality of innate immunity can lead to ocular surface inflammation. Copyright 2009 Elsevier Inc. All

  17. Referred pain areas of active myofascial trigger points in head, neck, and shoulder muscles, in chronic tension type headache.

    Science.gov (United States)

    Fernández-de-Las-Peñas, César; Ge, Hong-You; Alonso-Blanco, Cristina; González-Iglesias, Javier; Arendt-Nielsen, Lars

    2010-10-01

    Our aim was to analyze the differences in the referred pain patterns and size of the areas of those myofascial trigger points (TrPs) involved in chronic tension type headache (CTTH) including a number of muscles not investigated in previous studies. Thirteen right handed women with CTTH (mean age: 38 ± 6 years) were included. TrPs were bilaterally searched in upper trapezius, sternocleidomastoid, splenius capitis, masseter, levator scapulae, superior oblique (extra-ocular), and suboccipital muscles. TrPs were considered active when both local and referred pain evoked by manual palpation reproduced total or partial pattern similar to a headache attack. The size of the referred pain area of TrPs of each muscle was calculated. The mean number of active TrPs within each CTTH patient was 7 (95% CI 6.2-8.0). A greater number (T = 2.79; p = 0.016) of active TrPs was found at the right side (4.2 ± 1.5) when compared to the left side (2.9 ± 1.0). TrPs in the suboccipital muscles were most prevalent (n = 12; 92%), followed by the superior oblique muscle (n =11/n = 9 right/left side), the upper trapezius muscle (n = 11/n = 6) and the masseter muscle (n = 9/n=7). The ANOVA showed significant differences in the size of the referred pain area between muscles (F = 4.7, p = 0.001), but not between sides (F = 1.1; p = 0.3): as determined by a Bonferroni post hoc analysis the referred pain area elicited by levator scapulae TrPs was significantly greater than the area from the sternocleidomastoid (p = 0.02), masseter (p = 0.003) and superior oblique (p = 0.001) muscles. Multiple active TrPs exist in head, neck and shoulder muscles in women with CTTH. The referred pain areas of TrPs located in neck muscles were larger than the referred pain areas of head muscles. Spatial summation of nociceptive inputs from multiple active TrPs may contribute to clinical manifestations of CTTH. Copyright © 2009 Elsevier Ltd. All rights reserved.

  18. Measurement of ocular torsion variation following superior oblique tenectomy

    Directory of Open Access Journals (Sweden)

    Bruna Lana Ducca

    2014-12-01

    Full Text Available Purposes: To objectively evaluate the torsional effect of the superior oblique muscle-weakening surgery using the tenectomy technique proposed by Souza-Dias. Methods: The present prospective study included 10 patients (20 eyes with horizontal strabismus, bilateral superior oblique overaction and A-pattern of 15 to 30 prism diopters who underwent superior oblique tenectomy. Objective assessment of ocular torsion was performed by retinography immediately before and one month after surgery. The amount of ocular torsion was determined by measuring the angle formed by a horizontal line drawn across the geometric center of the optic disc and a second line connecting this point to the fovea. Results: The median preoperative angle was 5.56° in the right eyes and -3.43° in the left eyes. The median postoperative angle was 1.84° in the right eyes and -3.12° in the left eyes. The angle variation was statistically significant in both eyes (p=0.012 and p=0.01, respectively. Conclusion: The present study suggests that superior oblique tenectomy has an extorter effect, decreasing the intorsion detected on overaction of this muscle.

  19. Ocular involvement in patients with spondyloarthritis.

    Science.gov (United States)

    Bacchiega, Ana Beatriz Santos; Balbi, Gustavo Guimarães Moreira; Ochtrop, Manuella Lima Gomes; de Andrade, Francisco Assis; Levy, Roger Abramino; Baraliakos, Xenofon

    2017-03-18

    Ocular inflammatory diseases can present as isolated conditions but also as part of systemic inflammatory diseases. Anterior uveitis is closely related to SpA and shares the common genetic background of HLA-B27. Other ocular manifestations, such as episcleritis and scleritis, may also occur, although less frequently. Therefore, ocular involvement has been included as one of the important clinical features of SpA in the recently published classification criteria for axial and peripheral disease. However, there are a wide variety of aetiologies for ocular diseases and this must be considered in assessment of SpA.

  20. Extra and intradural spinal Hemangioblastoma Hemangioblastoma espinal extra e intradural Hemangioblastoma espinhal extra e intradural

    Directory of Open Access Journals (Sweden)

    Marcelo Campos Moraes Amato

    2012-09-01

    Full Text Available Hemangioblastomas of the central nervous system (CNS are low-grade highly vascularized tumors that may be sporadic or associated with Von Hippel-Lindau disease. Extradural hemangioblastomas are uncommon and those located extra and intradurally are even rarer. This study uses an illustrative case and literature review to discuss the difficulties to consider the correct diagnosis and to select the best surgical approach. A 57 years-old white male patient presented with myelopathy and right C5 radiculopathy. The images showed a lobulated, hourglass shaped, highly enhanced extra/intradural lesion that occupied the spinal canal and widened the C4-C5 right intervertebral foramen. Total resection of the intradural lesion was achieved through a posterior approach, but the extradural part could only be partially removed. Complete improvement was observed after four months of follow-up and the residual tumor has been followed up clinically and radiologically. Even though the preoperative impression was of a spinal schwannoma, the histopathological examination revealed grade I hemangioblastoma as per WHO. Despite their rarity, current complementary exams allow considering the diagnosis of hemangioblastoma preoperatively. That is essential to a better surgical planning in view of the particular surgical features of this lesion.Hemangioblastomas del sistema nervioso central (SNC son tumores altamente vascularizados, de grado bajo, que pueden ser esporádicos o vinculados a la enfermedad de Von Hippel-Lindau. Hemangioblastomas extradurales no son comunes, y aquellos localizados extra e intraduralmente son aún más raros. Este estudio usa un caso ilustrativo y la revisión de la literatura para analizar las dificultades cuanto a considerar el diagnóstico correcto y para seleccionar el mejor abordaje quirúrgico. Un paciente, hombre blanco de 57 años de edad, presentaba mielopatía con radiculopatía C5 derecha. Las imágenes mostraban lesión extra

  1. Modeling of mouse eye and errors in ocular parameters affecting refractive state

    Science.gov (United States)

    Bawa, Gurinder

    Rodents eye are particularly used to study refractive error state of an eye and development of refractive eye. Genetic organization of rodents is similar to that of humans, which makes them interesting candidates to be researched upon. From rodents family mice models are encouraged over rats because of availability of genetically engineered models. Despite of extensive work that has been performed on mice and rat models, still no one is able to quantify an optical model, due to variability in the reported ocular parameters. In this Dissertation, we have extracted ocular parameters and generated schematics of eye from the raw data from School of Medicine, Detroit. In order to see how the rays would travel through an eye and the defects associated with an eye; ray tracing has been performed using ocular parameters. Finally we have systematically evaluated the contribution of various ocular parameters, such as radii of curvature of ocular surfaces, thicknesses of ocular components, and refractive indices of ocular refractive media, using variational analysis and a computational model of the rodent eye. Variational analysis revealed that variation in all the ocular parameters does affect the refractive status of the eye, but depending upon the magnitude of the impact those parameters are listed as critical or non critical. Variation in the depth of the vitreous chamber, thickness of the lens, radius of the anterior surface of the cornea, radius of the anterior surface of the lens, as well as refractive indices for the lens and vitreous, appears to have the largest impact on the refractive error and thus are categorized as critical ocular parameters. The radii of the posterior surfaces of the cornea and lens have much smaller contributions to the refractive state, while the radii of the anterior and posterior surfaces of the retina have no effect on the refractive error. These data provide the framework for further refinement of the optical models of the rat and mouse

  2. A Study of Ocular Trauma Profile and Its Visual Outcome in Road Traffic Accidents

    Directory of Open Access Journals (Sweden)

    Abha Gahlot

    2015-09-01

    Full Text Available Background: This is a prospective study of ocular trauma profile related to road traffic accidents that presented to a tertiary care centre in Western Maharashtra. Aims and Objectives: To study the epidemiology and pattern of ocular trauma among the road traffic accident cases in western Maharashtra. Methodology: Hospital based study conducted from September 2013 to March 2015. 114 subjects (122 eyes were enrolled in the study. 8 of these subjects had bilateral ocular trauma. The examination involved assessment of visual acuity and description of nature and extent of ocular injury. The visual outcome was taken to be the best corrected vision at 3 months post trauma. The chi-square test was used to statistically analyze the data. Results: It was observed that 32.79% of injuries were extra ocular, 59.02% were closed globe intraocular injuries and 8.19% were open globe intraocular injuries. 78.69 % of the injuries were mild, 9.84% were moderate and 11.84% were severe. The visual outcome was good (visual acuity of more than 6/18 at 3 months post-trauma in 89.34%. Only 4.10% of the total cases studied had used safety measures viz., helmets or seat belts. A total of 12% of subjects were found to be under the influence of alcohol at the time of accident. Conclusions: Primary preventive approach such as promoting safe riding practices and strict implementation of traffic rules like riding at safe speed wearing helmet and avoiding alcohol before driving are needed to prevent road traffic accidents associated ocular morbidity. [Natl J Med Res 2015; 5(3.000: 211-215

  3. Extra informatie op matrixborden : mogelijkheden en effecten.

    NARCIS (Netherlands)

    Craen, S. de & Niet, M. de

    2002-01-01

    In this report, the possibilities of displaying extra safety information on Dynamic Message Signs (DMSs) are explored. The technical possibilities for placing extra information on the signs are looked at, and the road safety effects are examined. The information to be displayed can be divided into t

  4. Extra dimensions at particle colliders

    Energy Technology Data Exchange (ETDEWEB)

    Dvergsnes, Erik Wolden

    2004-08-01

    This thesis consists of an introduction where we consider different aspects of theories involving extra dimensions, together with four research publications (Papers I-IV) attached at the end. The introductional chapters should serve as background material for better understanding the models on which the articles are based. In Chap. 4 we also present some plots not included in the papers. The topic of Papers I-III is graviton induced Bremsstrahlung. In Paper I we consider the contribution to this process from graviton exchange through gluon-gluon fusion at the LHC, compared to the QED background. Only final-state radiation is considered in Paper I, whereas in Paper II we extend this work to include also the quark-antiquark annihilation with graviton exchange, as well as initial-state radiation for both graviton and Standard Model exchange. Paper III is a study of graviton-induced Bremsstrahlung at e{sup +}e{sup -} colliders, including both initial- and final-state radiation. Paper IV is devoted to a study of the center-edge asymmetry at hadron colliders, an asymmetry which previously had been studied for e{sup +}e{sup -} colliders. The center-edge asymmetry can be used as a method of distinguishing between spin-1 and spin-2 exchange, something which will be of major importance if a signal is observed.

  5. Interferometry for ocular microtremor measurement.

    Science.gov (United States)

    Boyle, G; Coakley, D; Malone, J F

    2001-01-01

    The eyes of all normal subjects undergo a continuous, low-amplitude, high-frequency tremor called ocular microtremor (OMT). A number of potential clinical applications of OMT have been identified, including the prediction of outcome in coma. To date, OMT has been investigated primarily with an eye-contacting piezoelectric probe. We describe a laser-based, noncontacting, interferometric technique for the measurement of OMT. The technique employs an in-plane-sensitive, phase-modulating speckle interferometer to detect the movement of the sclera, or white of the eye.

  6. [Ocular changes in Down's syndrome].

    Science.gov (United States)

    Koraszewska-Matuszewska, B; Pieczara, E; Samochowiec-Donocik, E; Nawrocka, L

    1994-01-01

    The authors analyzed the kind of ocular changes and methods of therapy in 34 children, aged 5 months to 14 years, treated in the clinic in the years 1982-1992. The most frequent change was congenital cataract. The other signs observed were: Brushfield's spots, alternate esotropia, nystagmus, partial optic atrophy, retinal detachment, congenital glaucoma, ectropion and keratoconus. Occurrence of several anomalies were frequent. The adequate surgical treatment was applied depending on the kind of changes. Cataract extraction was made by aspiration method. Visual acuity improved in 58.8% of eyes.

  7. Ocular dirofilariasis in Dubai, UAE

    Directory of Open Access Journals (Sweden)

    Mittal Mamta

    2008-01-01

    Full Text Available A rare occurrence of ocular subconjunctival dirofilariasis in a 53-year-old healthy Indian male working in Dubai, UAE presenting with an acute red eye is reported. Surgical excision under topical anesthesia was carried out uneventfully in the outpatient clinic. The live worm removed from the subconjunctival space was identified as Dirofilaria repens on the basis of microscopic examination and histopathology. Surgical excision of subconjunctival dirofilariasis is safe in an outpatient setting and curative precluding the need for further systemic antihelminthics.

  8. Raman Spectroscopy of Ocular Tissue

    Science.gov (United States)

    Ermakov, Igor V.; Sharifzadeh, Mohsen; Gellermann, Warner

    The optically transparent nature of the human eye has motivated numerous Raman studies aimed at the non-invasive optical probing of ocular tissue components critical to healthy vision. Investigations include the qualitative and quantitative detection of tissue-specific molecular constituents, compositional changes occurring with development of ocular pathology, and the detection and tracking of ocular drugs and nutritional supplements. Motivated by a better understanding of the molecular mechanisms leading to cataract formation in the aging human lens, a great deal of work has centered on the Raman detection of proteins and water content in the lens. Several protein groups and the hydroxyl response are readily detectable. Changes of protein compositions can be studied in excised noncataractous tissue versus aged tissue preparations as well as in tissue samples with artificially induced cataracts. Most of these studies are carried out in vitro using suitable animal models and conventional Raman techniques. Tissue water content plays an important role in optimum light transmission of the outermost transparent ocular structure, the cornea. Using confocal Raman spectroscopy techniques, it has been possible to non-invasively measure the water to protein ratio as a measure of hydration status and to track drug-induced changes of the hydration levels in the rabbit cornea at various depths. The aqueous humor, normally supplying nutrients to cornea and lens, has an advantageous anterior location for Raman studies. Increasing efforts are pursued to non-invasively detect the presence of glucose and therapeutic concentrations of antibiotic drugs in this medium. In retinal tissue, Raman spectroscopy proves to be an important tool for research into the causes of macular degeneration, the leading cause of irreversible vision disorders and blindness in the elderly. It has been possible to detect the spectral features of advanced glycation and advanced lipooxydation end products in

  9. Cyclosporine for Ocular Inflammatory Diseases

    Science.gov (United States)

    Kaçmaz, R. Oktay; Kempen, John H.; Newcomb, Craig; Daniel, Ebenezer; Gangaputra, Sapna; Nussenblatt, Robert B.; Rosenbaum, James T.; Suhler, Eric B.; Thorne, Jennifer E.; Jabs, Douglas A.; Levy-Clarke, Grace A.; Foster, C. Stephen

    2009-01-01

    Purpose To evaluate the clinical outcomes of cyclosporine treatment for non-infectious ocular inflammation Design Retrospective cohort study Participants Three hundred seventy-three patients with non-infectious ocular inflammation managed at four tertiary ocular inflammation clinics in the United States observed to use cyclosporine as a single non-corticosteroid immunosuppressive agent to their treatment regimen, between 1979-2007 inclusive. Methods Participants were identified from the Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study. Demographic and clinical characteristics, including dosage of cyclosporine and main outcome measures were obtained for every eye of every patient at every visit via medical record review by trained expert reviewers. Main Outcome Measures: Control of inflammation, sustained control after reducing corticosteroid dosages, and discontinuation of therapy because of toxicity. Results Of the 373 patients (681 eyes) initiating cyclosporine monotherapy, 33.4% by six months and 51.9% by one year gained sustained, complete control of inflammation over at least two visits spanning at least 28 days. Approximately 25% more improved to a level of slight inflammatory activity by each of these time points. Corticosteroid-sparing success (completely controlled inflammation for at least 28 days with prednisone 10 mg/day or less) was achieved by 22.1% by six months and 36.1% within one year. Toxicity led to discontinuation of therapy within one year by 10.7% of the population. Patients over 55 years of age were over 3-fold more likely to discontinue therapy because of toxicity than patients ages 18-39 years. Doses of 151-250 mg/day tended to be more successful than lower doses, and were not associated with a higher discontinuation for toxicity rate; higher doses did not appear to offer a therapeutic advantage. Conclusion Cyclosporine, with corticosteroid therapy as indicated, was modestly effective for controlling ocular inflammation

  10. Trauma ocular a globo abierto en zona I Open globe ocular trauma in zone I

    Directory of Open Access Journals (Sweden)

    Dunia Cruz Izquierdo

    2011-12-01

    Full Text Available El trauma ocular, a globo abierto o cerrado, ocasiona gran ansiedad al lesionado, ya que su pronóstico visual está en relación con la conducta médica en el servicio de urgencia. La conducta debe ser específica para cada caso y así minimizar las complicaciones que se presentan en estos pacientes como: catarata y glaucoma de muy difícil manejo. Se describe un paciente de 43 años de edad que sufrió un trauma vegetal a globo abierto en zona I, con una espina de Marabú en el ojo derecho hace 3 meses. Refirió disminución de la agudeza visual de movimiento de mano a un metro, lagrimeo y sensación de cuerpo extraño. Acude al Instituto "Ramón Pando Ferrer", con la herida corneal suturada en su provincia y catarata traumática. Se le realizó facoaspiración de cristalino, pupiloplastia, implante de lente intraocular de cámara posterior, con seguimiento a las 24 horas y al mes de operado. El paciente alcanzó una agudeza visual con corrección óptica de 1,0 en la cartilla de Snellen al mes de operado.The ocular trauma, either open or closed globe, causes great anxiety to the injured, since the visual prognosis depends on an adequate medical performance at the emergency service. The performance should be specific to the case in question in order to minimize the possible complications that might occur such as cataract and glaucoma, very difficult to be managed. The case of a 43 year-old patient, who suffered an open globe vegetal trauma in area 1 in his right eye caused by one marabú thorn 3 months ago, was presented. He mentioned decreased visual acuity at one-meter distance, tears and feeling of foreign body in the eye. He went to “Ramón Pando Ferrer" Cuban Institute of Ophthalmology, with his corneal wound sutured and traumatic cataract. He underwent phacoaspiration in the crystalline, pupiloplasty, intraocular lens implantation in the posterior chamber and he was followed-up the first 24 hours and one month after surgery. The

  11. Ocular Morbidity in the Correction of Orbital Hypertelorism and Dystopia: A 15-Year Experience.

    Science.gov (United States)

    Glass, Graeme E; Hon, Kate A V; Schweibert, Kemmy; Bowman, Richard; Jones, Barry M; Dunaway, David J; Britto, Jonathan A

    2017-04-01

    Complex surgery for appearance change is controversial. Correction of orbital hypertelorism risks diplopia and loss of stereopsis for aesthetic gain. The risk-to-benefit ratio remains ill-defined. The aim of this study was to define specific ocular morbidity following orbital translocation. The authors compared stable preoperative and postoperative orthoptic indices (i.e., angle of strabismus, ocular motility, and acuity) for 23 consecutive patients who underwent orbital translocation between 2000 and 2015 and noted the requirement for corrective surgery. Eighteen patients underwent 33 box osteotomies (15 bilateral and three unilateral). Five patients underwent facial bipartition. Diagnosis was craniofrontonasal dysplasia in 11, frontonasal dysplasia in six, facial cleft in four, and Saethre-Chotzen syndrome in two cases. Median grade of orbital hypertelorism was III. Median age at surgery was 13 years (range, 5 to 17 years). Nontransient change (favorable or unfavorable) in angle of strabismus was noted in 14 patients. Ocular motility was altered in 12. Six patients had stereopsis preoperatively that was disrupted in two cases because of changes in ocular alignment and/or motility. There was one perioperative ophthalmic emergency (superior orbital fissure syndrome) and three acute reexplorations for external ocular muscle entrapment. Corrective surgery for strabismus was performed for four patients. Three required secondary canthopexy and three required surgery for blepharoptosis. Orbital translocation is associated with ocular risks including changes to angle of strabismus, ocular motility, and (when present) loss of stereopsis. Secondary surgery to correct strabismus or eyelid malposition is common. Orbital translocation is an operative process, not a single procedure. Therapeutic, IV.

  12. Fungal keratitis associated with ocular rosacea.

    Science.gov (United States)

    Jain, Vandana; Shome, Debraj; Sajnani, Manoj; Natarajan, Sundaram

    2010-06-01

    In order to report fungal keratitis in patients of ocular rosacea, a retrospective review of all cases of fungal keratitis was undertaken. Cases in which ocular rosacea coexisted were identified and included in the study. The clinical course of patients thus identified was studied from the medical records and outcomes were evaluated. A total of three cases of fungal keratitis with coexisting ocular rosacea were identified. All three patients were known cases of acne rosacea with an intermittent, irregular treatment for the same. Previous history of contact lens use, ocular surgery or trauma was not present in any of the cases. Microbiological evaluation revealed Aspergillus flavus as the causative organism in two patients and an unidentified hyaline fungus in the third. Patients received simultaneous therapy for fungal keratitis and ocular rosacea. The ocular surface completely stabilized and the infiltrate resolved in all three cases. The chronic ocular surface changes and induced inflammation in ocular rosacea, along with the instillation of topical steroids for therapy, may create an environmental milieu favorable for fungal keratitis. Microbiological evaluation should be considered, even in cases of suspected sterile keratitis, prior to treatment with topical steroids, so as to prevent the possible worsening of an associated infective corneal condition.

  13. Ocular diseases: immunological and molecular mechanisms

    Directory of Open Access Journals (Sweden)

    Jing Song

    2016-05-01

    Full Text Available Many factors, such as environmental, microbial and endogenous stress, antigen localization, can trigger the immunological events that affect the ending of the diverse spectrum of ocular disorders. Significant advances in understanding of immunological and molecular mechanisms have been researched to improve the diagnosis and therapy for patients with ocular inflammatory diseases. Some kinds of ocular diseases are inadequately responsive to current medications; therefore, immunotherapy may be a potential choice as an alternative or adjunctive treatment, even in the prophylactic setting. This article first provides an overview of the immunological and molecular mechanisms concerning several typical and common ocular diseases; second, the functions of immunological roles in some of systemic autoimmunity will be discussed; third, we will provide a summary of the mechanisms that dictate immune cell trafficking to ocular local microenvironment in response to inflammation.

  14. Adult Ocular Toxocariasis Mimicking Ciliary Body Malignancy

    Directory of Open Access Journals (Sweden)

    Ahmad M. Mansour

    2014-01-01

    Full Text Available Purpose. To discuss an unusual presentation of ocular toxocariasis. Methods. Case report. Results. A 40-year-old woman presented with decreased vision in the left eye with a long history of recurrent red eye from uveitis. Eosinophilia and positive ELISA titers for Toxocara canis favored the diagnosis of ocular toxocariasis. Over 3 months, an anterior scleral mass had a rapid growth raising the possibility of medulloepithelioma, which rarely can mimic uveitic syndromes. Surgical plan changed from local excision to enucleation. Histopathology demonstrated a large homogeneous mass of chronic inflammatory cells with inflammation of the overlying thinned out sclera, medial rectus insertion, and limbal cornea. The triad of peripheral granuloma, eosinophilia, and positive blood serology established the diagnosis of ocular toxocariasis. Conclusions. Ocular toxocariasis can mimic ocular malignancy such as medulloepithelioma in adults and rarely presents as an anterior scleral mass.

  15. Clinical and immunological responses in ocular demodecosis.

    Science.gov (United States)

    Kim, Jae Hoon; Chun, Yeoun Sook; Kim, Jae Chan

    2011-09-01

    The purpose of this study was to investigate clinical and immunological responses to Demodex on the ocular surface. Thirteen eyes in 10 patients with Demodex blepharitis and chronic ocular surface disorders were included in this study and treated by lid scrubbing with tea tree oil for the eradication of Demodex. We evaluated ocular surface manifestations and Demodex counts, and analyzed IL-1β, IL-5, IL-7, IL-12, IL-13, IL-17, granulocyte colony-stimulating factor, and macrophage inflammatory protein-1β in tear samples before and after the treatment. All patients exhibited ocular surface manifestations including corneal nodular opacity, peripheral corneal vascularization, refractory corneal erosion and infiltration, or chronic conjunctival inflammatory signs before treatment. After treatment, Demodex was nearly eradicated, tear concentrations of IL-1β and IL-17 were significantly reduced and substantial clinical improvement was observed in all patients. In conclusion, we believe that Demodex plays an aggravating role in inflammatory ocular surface disorders.

  16. Custom ocular prosthesis: A palliative approach

    Directory of Open Access Journals (Sweden)

    Prachi Thakkar

    2015-04-01

    Full Text Available The goal of palliative care is the achievement of the best quality of life for patients and their families. Eyes are generally the first features of the face to be noticed. Loss of an eye is a traumatic event which has a crippling effect on the psychology of the patient. Several ocular and orbital disorders require surgical intervention that may result in ocular defects. An ocular prosthesis is fabricated to restore the structure, function, and cosmetics of the defects created by such conditions. Although an implant eye prosthesis has a superior outcome, due to economic factors it may not be a feasible option for all patients. Therefore, a custom-made ocular prosthesis is a good alternative. This case report presents a palliative treatment for a patient with an enucleated eye by fabricating a custom ocular prosthesis which improved his psychological, physical, social, functional, emotional and spiritual needs.

  17. Anterior Segment Imaging in Combat Ocular Trauma

    Directory of Open Access Journals (Sweden)

    Denise S. Ryan

    2013-01-01

    Full Text Available Purpose. To evaluate the use of ocular imaging to enhance management and diagnosis of war-related anterior segment ocular injuries. Methods. This study was a prospective observational case series from an ongoing IRB-approved combat ocular trauma tracking study. Subjects with anterior segment ocular injury were imaged, when possible, using anterior segment optical coherence tomography (AS-OCT, confocal microscopy (CM, and slit lamp biomicroscopy. Results. Images captured from participants with combat ocular trauma on different systems provided comprehensive and alternate views of anterior segment injury to investigators. Conclusion. In combat-related trauma of the anterior segment, adjunct image acquisition enhances slit lamp examination and enables real time In vivo observation of the cornea facilitating injury characterization, progression, and management.

  18. Ocular manifestations of Hansen's disease.

    Science.gov (United States)

    Sekhar, G C; Vance, G; Otton, S; Kumar, S V; Stanley, J N; Rao, G N

    1994-01-01

    A detailed ophthalmic evaluation including slitlamp biomicroscopy, measurement of corneal sensitivity using Cochet and Bonnet aesthesiometer, Schirmer's test and Goldmann applanation tonometry was carried out in 89 patients of Hansen's disease attending the leprosy clinic with or without ocular symptoms and willing to undergo eye evaluation. Thirty-one patients had lepromatous leprosy (8 with erythema nodosum leprosum), 56 patients had borderline disease (13 with reversal reactions) and 2 had tuberculoid disease. In addition to the well documented changes of lagophthalmos (6.7%), uveitis (7.3%) and cataracts (19%), we noted prominent corneal nerves in 133 eyes (74.7%), beaded corneal nerves in 19 eyes (10.7%), corneal scarring in 10 eyes (5.6%), corneal hypoaesthesia in 51 eyes (28%) and dry eye in 18 eyes (13%). Beaded corneal nerves and/or stomal infiltrates occurred mainly in the lepromatous group (75%). Ocular hypotony (IOP less than 12 mm Hg) was not seen more frequently in Hansen's as compared to age and sex matched controls with refractive errors or cataracts (33.7%, vs. 37.8%, p = 0.33). Our study highlights the primary corneal involvement with corneal neuropathy as the predominant feature of Hansen's disease.

  19. Imaging the ocular motor nerves

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, Teresa [Department of Radiology, Leiden University Medical Center (Netherlands)], E-mail: T.A.Ferreira@lumc.nl; Verbist, Berit [Department of Radiology, Leiden University Medical Center (Netherlands)], E-mail: B.M.Verbist@lumc.nl; Buchem, Mark van [Department of Radiology, Leiden University Medical Center (Netherlands)], E-mail: M.A.van_Buchem@lumc.nl; Osch, Thijs van [C.J. Gorter for High-Field MRI, Department of Radiology, Leiden University Medical Center (Netherlands)], E-mail: M.J.P.van_Osch@lumc.nl; Webb, Andrew [C.J. Gorter for High-Field MRI, Department of Radiology, Leiden University Medical Center (Netherlands)], E-mail: A.Webb@lumc.nl

    2010-05-15

    The ocular motor nerves (OMNs) comprise the oculomotor, trochlear and the abducens nerves. According to their course, they are divided into four or five anatomic segments: intra-axial, cisternal, cavernous and intra-orbital and, for the abducens nerve, an additional interdural segment. Magnetic resonance imaging is the imaging method of choice in the evaluation of the normal and pathologic ocular motor nerves. CT still plays a limited but important role in the evaluation of the intraosseous portions at the skull base and bony foramina. We describe for each segment of these cranial nerves, the normal anatomy, the most appropriate image sequences and planes, their imaging appearance and pathologic conditions. Magnetic resonance imaging with high magnetic fields is a developing and promising technique. We describe our initial experience with a Phillips 7.0 T MRI scanner in the evaluation of the brainstem segments of the OMNs. As imaging becomes more refined, an understanding of the detailed anatomy is increasingly necessary, as the demand on radiology to diagnose smaller lesions also increases.

  20. Imaging the ocular motor nerves.

    Science.gov (United States)

    Ferreira, Teresa; Verbist, Berit; van Buchem, Mark; van Osch, Thijs; Webb, Andrew

    2010-05-01

    The ocular motor nerves (OMNs) comprise the oculomotor, trochlear and the abducens nerves. According to their course, they are divided into four or five anatomic segments: intra-axial, cisternal, cavernous and intra-orbital and, for the abducens nerve, an additional interdural segment. Magnetic resonance imaging is the imaging method of choice in the evaluation of the normal and pathologic ocular motor nerves. CT still plays a limited but important role in the evaluation of the intraosseous portions at the skull base and bony foramina. We describe for each segment of these cranial nerves, the normal anatomy, the most appropriate image sequences and planes, their imaging appearance and pathologic conditions. Magnetic resonance imaging with high magnetic fields is a developing and promising technique. We describe our initial experience with a Phillips 7.0T MRI scanner in the evaluation of the brainstem segments of the OMNs. As imaging becomes more refined, an understanding of the detailed anatomy is increasingly necessary, as the demand on radiology to diagnose smaller lesions also increases.

  1. Ocular biomarkers of Alzheimer's disease.

    Science.gov (United States)

    Heaton, George R; Davis, Benjamin M; Turner, Lisa A; Cordeiro, Maria F

    2015-01-01

    Alzheimer's disease (AD) is a devastating neurodegenerative disease characterised clinically by a progressive decline in executive functions, memory and cognition. Classic neuropathological hallmarks of AD include intracellular hyper-phosphorylated tau protein which forms neurofibrillary tangles (NFT), and extracellular deposits of amyloid β (Aβ) protein, the primary constituent of senile plaques (SP). The gradual process of pathogenic amyloid accumulation is thought to occur 10-20 years prior to symptomatic manifestation. Advance detection of these deposits therefore offers a highly promising avenue for prodromal AD diagnosis. Currently, the most sophisticated method of 'probable AD' diagnosis is via neuroimaging or cerebral spinal fluid (CSF) biomarker analysis. Whilst these methods have reported a high degree of diagnostic specificity and accuracy, they fall significantly short in terms of practicality; they are often highly invasive, expensive or unsuitable for large-scale population screening. In recent years, ocular screening has received substantial attention from the scientific community due to its potential for non-invasive and inexpensive central nervous system (CNS) imaging. In this appraisal we build upon our previous reviews detailing ocular structural and functional changes in AD (Retinal manifestations of Alzheimer's disease, Alzheimer's disease and Retinal Neurodegeneration) and consider their use as biomarkers. In addition, we present an overview of current advances in the use of fluorescent reporters to detect AD pathology through non-invasive retinal imaging.

  2. Paraganglioma funcional extra-adrenal

    Directory of Open Access Journals (Sweden)

    Laura Arroyo-Martínez

    2006-03-01

    Full Text Available Los paragangliomas funcionales son tumores raros, se originan del tejido cromafín extraadrenal productor de catecolaminas, con frecuencia son malignos y tienen alta incidencia de enfermedad persistente o recurrente¹. Se les conoce como: glomus, quemodectomas, paragangliomas cromafines y glomerulocitomas. La localización es diversa y refleja la distribución paraganglionar en el cuerpo, desde la base del cráneo hasta el piso pélvico. Los paragangliomas se encuentran en donde hay ganglios del sistema autónomo, sin embargo, aproximadamente el 90% de estos tumores aparecen en las glándulas suprarrenales (y constituyen los feocromocitomas y el 10% restante tienen una ubicación extraadrenal, mas se ha dicho que su incidencia puede ser subestimada, variando del 18% al 22% en adultos, y en niños hasta un 30%. Los extra-adrenales se originan con mayor frecuencia en el abdomen (85%, otros en el tórax (12% y más raramente en la cabeza y el cuello (3% ². Los estudios de imágenes y la medición de la producción no fisiológica de catecolaminas pueden ayudar en el diagnóstico de esta entidad. La cirugía es el tratamiento de elección. Presentamos aquí el caso de una paciente de 32 años, primigesta con HTAIE que requirió cesárea, quien tuvo un postparto tórpido y pese a múltiples tratamientos antihipertensivos su patología fue de difícil manejo, con complicaciones oftálmicas. Tiempo después la paciente se estudia por hiperhidrosis, se solicitan exámenes de laboratorio e imágenes y se le documenta incidentalmente, una tumoración retroperitoneal izquierda, se le amplían los estudios, y se llega al diagnóstico correcto. La tumoración requirió resección quirúrgica. Tuvo un postoperatorio satisfactorio y la paciente egresó con control en la Consulta Externa.Functioning paragangliomas are rare tumors that produce catecholamines. They originate from extra-adrenal chromaffin cells. They are frequentIy malignant and are associated

  3. Muscle Disorders

    Science.gov (United States)

    Your muscles help you move and help your body work. Different types of muscles have different jobs. There are many problems that can affect muscles. Muscle disorders can cause weakness, pain or even ...

  4. Muscle Cramps

    Science.gov (United States)

    Muscle cramps are sudden, involuntary contractions or spasms in one or more of your muscles. They often occur ... minutes. It is a very common muscle problem. Muscle cramps can be caused by nerves that malfunction. Sometimes ...

  5. Extra cardiac activity detected on myocardial perfusion scintigraphy after intra-arterial injection of 99mTc-MIBI

    DEFF Research Database (Denmark)

    Afzelius, Pia; Henriksen, Jens H

    2008-01-01

    , prolongation of the study and interference of the extra cardiac activity with the cardiac image reconstructions. Whole-body scintigraphy disclosed an arterial flow distribution of activity to skeletal muscles in left shoulder and upper limb. CONCLUSION: Accidentally injected radiotracer retrogradely...... (dipyridamol) imaging and followed by rest imaging day 2 was performed. RESULTS: On day 2, when rest perfusion scintigraphy was carried out, extra cardiac activity was present in the left part of thorax and in the left upper extremity resulting in reduced accumulation of 99mTc-MIBI in cardiac tissue...... into the arterial system resulted in an unusual extra cardiac activity interfering with later image processing....

  6. Ocular torsion variation after superior oblique weakening procedure - a case report

    Directory of Open Access Journals (Sweden)

    Bruna Lana Ducca

    2012-09-01

    Full Text Available Purpose: to objectively evaluate the torsional effect of the tenectomy of the superior oblique muscle (SO. Design: case report of one of the patients of the group studied in the previous paper "Measurement of the ocular torsion variation after superior oblique tenectomy". Methods: case report of a patient with horizontal strabismus and bilateral SO muscle overaction who was submitted to bilateral SO tenectomy. Obejective access of ocular torsion was held by retinogrphy and a computer software (Autocad 2009. Results: the preoperative angle was 7.57 in the right eye and 0.66 in the left eye. Postoperative torsion angle was 4.22 in the right eye and -1.50 the left eye. Conclusion: the present case suggests that SO tenectomy has an extorter effect, decreasing the intorsion detected in case of SO overaction.

  7. Componentes oculares em anisometropia The ocular components in anisometropia

    Directory of Open Access Journals (Sweden)

    David Tayah

    2007-06-01

    Full Text Available OBJETIVO: Comparar as correlações dos componentes oculares (comprimento axial, comprimento do segmento anterior, poder médio da córnea, profundidade da câmara vítrea e poder refrativo equivalente com o erro refrativo total do olho portador da menor e da maior ametropia em anisométropes. MÉTODOS: Foi realizado um "survey" analítico conduzido em população de 68 anisométropes de duas ou mais dioptrias atendida no Ambulatório da Clinica Oftalmológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo Os anisométropes foram submetidos à refração estática objetiva e subjetiva, ceratometria e biometria ultra-sônica. RESULTADOS: Não houve diferença significativa entre os valores dos componentes oculares medidos dos olhos portadores da menor e da maior ametropia. Os olhos portadores da menor ametropia apresentaram as mesmas correlações significantes observadas em olhos emétropes, ou seja, correlação da refração com comprimento do segmento anterior e comprimento axial, e correlação do comprimento axial com poder corneano e profundidade da câmara vítrea. Os olhos portadores da maior ametropia apresentaram correlação significante da refração com o comprimento axial e do comprimento axial com a profundidade da câmara vítrea. Ainda em ambos os olhos observou-se correlação significante do poder do cristalino com a profundidade da câmara anterior. CONCLUSÃO: Os olhos portadores da menor ametropia desenvolveram as correlações mais freqüentemente observadas nos olhos emétropes. Os olhos portadores da maior ametropia não desenvolveram as mesmas correlações dos emétropes.PURPOSE: To asses the correlation between ocular components (axial length, anterior segment length, corneal power, vitreous length and equivalent power of the eye and refractive error in eyes with higher and lower ametropia of subjects with anisometropia. METHODS: An analytical survey was carried out in 68 patients

  8. Paraganglioma funcional extra-adrenal

    Directory of Open Access Journals (Sweden)

    Laura Arroyo-Martínez

    2006-03-01

    Full Text Available Los paragangliomas funcionales son tumores raros, se originan del tejido cromafín extraadrenal productor de catecolaminas, con frecuencia son malignos y tienen alta incidencia de enfermedad persistente o recurrente¹. Se les conoce como: glomus, quemodectomas, paragangliomas cromafines y glomerulocitomas. La localización es diversa y refleja la distribución paraganglionar en el cuerpo, desde la base del cráneo hasta el piso pélvico. Los paragangliomas se encuentran en donde hay ganglios del sistema autónomo, sin embargo, aproximadamente el 90% de estos tumores aparecen en las glándulas suprarrenales (y constituyen los feocromocitomas y el 10% restante tienen una ubicación extraadrenal, mas se ha dicho que su incidencia puede ser subestimada, variando del 18% al 22% en adultos, y en niños hasta un 30%. Los extra-adrenales se originan con mayor frecuencia en el abdomen (85%, otros en el tórax (12% y más raramente en la cabeza y el cuello (3% ². Los estudios de imágenes y la medición de la producción no fisiológica de catecolaminas pueden ayudar en el diagnóstico de esta entidad. La cirugía es el tratamiento de elección. Presentamos aquí el caso de una paciente de 32 años, primigesta con HTAIE que requirió cesárea, quien tuvo un postparto tórpido y pese a múltiples tratamientos antihipertensivos su patología fue de difícil manejo, con complicaciones oftálmicas. Tiempo después la paciente se estudia por hiperhidrosis, se solicitan exámenes de laboratorio e imágenes y se le documenta incidentalmente, una tumoración retroperitoneal izquierda, se le amplían los estudios, y se llega al diagnóstico correcto. La tumoración requirió resección quirúrgica. Tuvo un postoperatorio satisfactorio y la paciente egresó con control en la Consulta Externa.

  9. OCULAR COMPLICATIONS OF SILICONE OIL

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    Muhammad Kamran Khalid

    2016-06-01

    Full Text Available Objective: Silicone oil (SO is an invaluable tool in the management of complex retinal detachments (RDs. Injection of silicone oil is associated with a variety of ocular complications specially when it is kept for a long time and its removal is endangering retinal re-detachment. The objective of this study was to determine the frequencies of different ocular complications associated with silicone oil injection in our setup. Study Design: Case series. Place and Duration of Study: This study was conducted at Vitreo-retina division of Al-Shifa Trust Eye Hospital, Rawalpindi from January 2014 to June 2014. Material and Methods: A total of 30 patients were included in the study who underwent pars-planavitrectomy (PPV with silicone oil injection for complex retinal detachments. The patients who had reached between 3 months & 6 months of their postoperative period and were presenting with some complications related to silicone oil injection were included in the study. Their records were reviewed and pre-operative data were collected regarding state of the eye preoperatively. Then the post-operative complications were noted. The descriptive and analytical statistics of different variables were measured using SPSS-17.0 software. Results: Out of thirty patients included in our study 23 (76.7% were male and 7 (23.3% were female. The mean age was 21.53 ± 16.004 years and range was 66 years. The mean pre-operative intra-ocular pressure ( IOP was 14.0 ± 2.150 mmHg and range 8 mmHg and the mean post-operative IOP was 24.93 ± 13.889 mmHg and range 45 mmHg (p=0.001. The pre-operative PVR grade-C was absent in 12 (40% patients and was present in 18 (60% patients and post-operative PVR grade-C was absent in 24 (80% patients and was present in 6 (20% patients (p=0.004; McNemar test. Band keratopathy was seen in 8 (26.7% and corneal decompensation in 2 (6.7% patients. Emulsification of silicone oil was seen in 14 (46.7% patients. Rubeosisiridis was present in 2

  10. Directional sensitivity of anterior, posterior, and horizontal canal vestibulo-ocular neurons in the cat.

    Science.gov (United States)

    Brettler, S C; Baker, J F

    2001-10-01

    extraocular muscle excitation axis vectors. Only single examples of second-order vestibulo-ocular neuron vectors were approximately aligned with the pitch and roll coordinate axes. We conclude that second-order vestibulo-ocular neurons do not exclusively represent either the semicircular canal sensory coordinate frame or the extraocular muscle excitation motor coordinate frame, and instead are mostly distributed on a continuum between the input and output coordinate frames, with anterior canal neurons having the widest distribution of directionality.

  11. Racket sports. An ocular hazard.

    Science.gov (United States)

    Vinger, P F; Tolpin, D W

    1978-06-16

    Eighty-two injuries secondary to the racket sports were studied during a 15-month period. Ordinary glasses provided considerable protection in the play of tennis and badminton, but not in the play of squash and racquet ball. Plastic safety lenses (USA Standard Practice for Occupational and Educational Eye ,nd Face Protection, approved Sept 18, 1968 by the USA Standards Institute [ANSI Z87.1-1968]) mounted in a sturdy frame (industrial or athletic) or an eye protector are necessary for squash and racquet ball. Contact lenses provide no ocular protection. Males suffered more serious injuries than females, but injuries were not related to the age or experience of the players. Eye protection is recommended for the racket sports.

  12. Neurosurgical applications of ocular pneumoplethysmography.

    Science.gov (United States)

    Bingham, W F

    1981-05-01

    Ocular pneumoplethysmography (OPG), a semiautomated form of suction ophthalmodynamometry, was used to evaluate and follow 15 patients who underwent carotid endarterectomy and two patients in whom gradual carotid artery occlusion was performed for inoperable intracranial aneurysm. Postoperative corrected ophthalmic arterial pressures (COAP's) on the operated side in the carotid endarterectomy patients averaged 12.5 mm Hg higher than before surgery, the standard deviation being 4.9 mm Hg for clinically stable patients. There was no significant change in COAP on the contralateral side. Several problems were encountered in closing down carotid clamps, the most potentially serious being a precipitous fall in COAP with the final adjustment. The current uses of OPG and similar techniques are reviewed, and potential neurosurgical applications are discussed.

  13. Ocular allergy in the Asia Pacific region.

    Science.gov (United States)

    Katelaris, Constance H

    2011-10-01

    Allergic conjunctivitis (AC) represents a spectrum of disorders, comprising seasonal allergic conjunctivitis (SAC), perennial allergic conjunctivitis (PAC), atopic keratoconjunctivitis (AKC), vernal keratoconjunctivitis (VKC) and giant papillary conjunctivitis. Of these ocular allergy types, SAC and PAC are the most common.The most striking difference within this group of ocular diseases is that SAC and PAC remain self-limited without ocular surface damage, while AKC and VKC can compromise the cornea, causing ulcers and scarring and can ultimately lead to vision loss. Data on AC in the Asia Pacific is scarce however some understanding of prevalence of the condition has been obtained from the International Study of Asthma and Allergies in Childhood (ISAAC) studies and more recently from the Allergies in Asia Pacific study as well as some information from individual country surveys. Unfortunately none of this data has been collected using validated survey instruments specifically designed for AC. Surveys such as ISAAC have been predominantly concerned with respiratory allergic symptoms with questions added that incorporate some ocular symptoms. These questionnaires do not detect individuals who may have AC in the absence of allergic rhinitis. Using hospital ophthalmology outpatient populations for prevalence studies of ocular allergy immediately introduces a bias towards the more severe, complex forms of the condition as patients with the milder forms of SAR and PAR will rarely present to a hospital outpatient clinic. There is a real need for the development of validated questionnaires specifically addressing ocular allergy. There are no widely accessible studies examining prevalence of the complex forms of ocular allergy (AKC, VKC) in Asia Pacific region. This review will provide an overview of ocular allergy, its classification, clinical presentation and differential diagnosis, and will also discuss what is known about the epidemiology of ocular allergy in the

  14. Ocular Dominance and Handedness in Golf Putting.

    Science.gov (United States)

    Dalton, Kristine; Guillon, Michel; Naroo, Shehzad A

    2015-10-01

    In golf, the impact of eye-hand dominance on putting performance has long been debated. Eye-hand dominance is thought to impact how golfers judge the alignment of the ball with the target and the club with the ball, as well as how golfers visualize the line of the putt when making decisions about the force needed to hit the ball. Previous studies have all measured ocular dominance in primary gaze only, despite golfers spending a significant amount of their time in a putting stance (bent at the hips, head tilted down). Thus, the purpose of this study was to assess ocular dominance in both primary gaze (aligning the ball with the target) and putting gaze (addressing the ball and aligning the club). This study investigated measuring pointing ocular dominance in both primary and putting gaze positions on 31 golfers (14 amateur, 7 club professionals, and 10 top professionals). All players were right-handed golfers, although one reported having no hand dominance and one reported being strongly left hand dominant. The results showed that (1) primary and putting gaze ocular dominances are not equal, nor are they predictive of each other; (2) the magnitude of putting ocular dominance is significantly less than the magnitude of primary gaze ocular dominance; (3) ocular dominance is not correlated with handedness in either primary or putting gaze; and (4) eye-hand dominance is not associated with increased putting skill, although ocular dominance may be associated with increased putting success. It is important that coaches assess golfers' ocular dominance in both primary and putting gaze positions to ensure they have the most accurate information upon which to base their vision strategy decisions.

  15. Neuromuscular plasticity and rehabilitation of the ocular near response.

    Science.gov (United States)

    Schor, Clifton M

    2009-07-01

    The near response is composed of cross-coupled interactions between convergence and other distance-related oculomotor responses including accommodation, vertical vergence, and cyclovergence. The cross-coupling interactions are analogous to the body postural reflexes that maintain balance. Near-response couplings guide involuntary motor responses during voluntary shifts of distance and direction of gaze without feedback from defocus or retinal-image disparity. They optimize the disparity stimulus for stereoscopic depth perception and can be modified by optically induced sensory demands placed on binocular vision. In natural viewing conditions, the near response is determined by passive orbital mechanics and active-adaptable tonic components. For example, the normal coupling of vertical vergence with convergence in tertiary gaze is partly a byproduct of passive orbital mechanics. Both, adapted changes of vertical vergence in response to anisophoria, produced by unequal ocular magnification (aniseikonia), and adapted changes in the orientation of Listing's plane in response to torsional disparities can be achieved by a combination of passive orbital mechanics and neural adjustments for the control of the vertical vergence and cyclovergence. Adaptive adjustments are coupled with gaze direction, convergence angle, and head tilt. Several adaptation studies suggest that it is possible to achieve non-linear changes in the coupling of both vertical vergence and cyclovergence with gaze direction. This coupling can be achieved with changes in neural control signals of ocular elevator muscles that are cross-coupled with both convergence and direction of tertiary gaze. These linear and non-linear coupling interactions can be adapted to compensate for (1) anisophoria induced by spectacle corrections for anisometropia, (2) accommodative esotropia, (3) convergence excess and insufficiency, and (4) non-concomitant deviations with ocular torticollis associated with trochlear palsy

  16. Extra dimensions in space and time

    CERN Document Server

    Bars, Itzhak

    2010-01-01

    Covers topics such as Einstein and the Fourth Dimension; Waves in a Fifth Dimension; and String Theory and Branes Experimental Tests of Extra Dimensions. This book offers a discussion on Two-Time Physics

  17. Pasta de azeite versus azeite virgem extra

    OpenAIRE

    Dias, Susana Marisa da Cunha

    2009-01-01

    Mestrado em Engenharia Alimentar - Instituto Superior de Agronomia Innovative products of high nutritional quality, with healthy benefits and extended conservation are an asset to the food sector. With beneficial health properties and high nutritional quality, extra virgin olive oil is an extraordinary fat, thanks to its unique chemical composition. The olive oil spread, subject of this study, is an innovative product, created from extra virgin olive oil, with a consistency ...

  18. Toxocariosis Ocular en Menores de Edad

    Directory of Open Access Journals (Sweden)

    Norma Ocampo

    2001-04-01

    Full Text Available La toxocariosis es una geohelmintiosis producida por la ingestión de
    huevos de Toxocara canis y T. catis, cuyos hospederos definitivos son el perro y el gato. En el humano las larvas producen el Síndrome de Migración Larvaria Visceral y Ocular; en este último produce una enfermedad grave que puede semejar un retinoblastoma (1,2. Los niños son más susceptibles a adquirir esta infección (3. Nuestro objetivo es determinar la frecuencia de toxocariosis ocular en menores de edad con sintomatología ocular.

  19. Unusual ocular manifestations of silent sinus syndrome

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    Fabricio Lopes da Fonseca

    2014-01-01

    Full Text Available Silent sinus syndrome is an acquired condition in which there is a gradual collapse of the orbital floor and inward retraction of the maxillary sinus (atelectasis of the maxillary sinus. This in turn may cause associated ocular occurrences of enophthalmos and hypotropia. This is a report of an 8 year-old boy with silent sinus syndrome and associated ocular motility disorders. The association between silent sinus syndrome and ocular motility disturbance has been recently described in the literature. However, this is an infrequent association, mainly in childhood.

  20. [Penetrating ocular trauma with intraocular foreign body].

    Science.gov (United States)

    Musat, O; Ochinciuc, Uliana; Gutu, Tatiana; Cristescu, T R; Coman, Corina

    2012-01-01

    We present the case of a 65 years old pacient which was admitted for the sudden decrease of visual acuity in the left eye, accompanied by ocular pain and conjunctival hiperemia, simptoms appeared after an ocular trauma. After the clinical and paraclinical examination we determined the diagnosis of OS: Penetrating ocular trauma with retention of a foreign body; posttraumatic cataract. Surgical treatement was warrented and we performed OS : Facoemulsification + PFK implant in sulcus + 23 Ga posterior vitrectomy + peeling of the posterior hyaloid membrane + extraction of the foreign body + LASER endofotocoagulation + transscleral cryotherapy + SF6 gas injection. The post-operatory evolution was favorable.

  1. OCULAR SYPHILIS IN A KIDNEY TRANSPLANT RECIPIENT

    Science.gov (United States)

    ROMAO, Elen A.; BOLELLA, Valdes R.; NARDIN, Maria Estela P.; HABIB-SIMAO, Maria Lucia; FURTADO, João Marcelo; MOYSES-NETO, Miguel

    2016-01-01

    We present a case of ocular syphilis after a renal transplantation involving progressive vision loss without clinically identifiable ocular disease. Electroretinography showed signs of ischemia, especially in the internal retina. A serological test was positive for syphilis. Lumbar puncture revealed lymphocytic meningitis and a positive serologic test for syphilis in the cerebrospinal fluid. The patient was treated with penicillin, and had a quick vision improvement. In the case of transplant recipients, clinicians should always consider the diagnosis of ocular syphilis in cases with unexplained visual acuity decrement, as this condition may cause serious complications if not treated. PMID:27253748

  2. Editorial: Focus on Extra Space Dimensions

    Science.gov (United States)

    Agashe, Kaustubh; Pomarol, Alex

    2010-07-01

    Experiments at the Large Hadron Collider (LHC) have just started. In addition to verifying the Standard Model (SM) of particle physics, these experiments will probe a new energy frontier and test extensions of the SM. The existence of extra dimensions is one of the most attractive possibilities for physics beyond the SM. This focus issue contains a collection of articles addressing both theoretical and phenomenological aspects of extra-dimensional models. Focus on Extra Space Dimensions Contents Minimal universal extra dimensions in CalcHEP/CompHEP AseshKrishna Datta, Kyoungchul Kong and Konstantin T Matchev Disordered extra dimensions Karim Benakli Codimension-2 brane-bulk matching: examples from six and ten dimensions Allan Bayntun, C P Burgess and Leo van Nierop Gauge threshold corrections in warped geometry Kiwoon Choi, Ian-Woo Kim and Chang Sub Shin Holographic methods and gauge-Higgs unification in flat extra dimensions Marco Serone Soft-wall stabilization Joan A Cabrer, Gero von Gersdorff and Mariano Quirós Warped five-dimensional models: phenomenological status and experimental prospects Hooman Davoudiasl, Shrihari Gopalakrishna, Eduardo Pontón and José Santiago

  3. Relationship between sphenomandibular muscle hyperactivity and visual symptoms

    Directory of Open Access Journals (Sweden)

    Raulino Naves Borges

    2012-01-01

    Full Text Available This was an observational, descriptive study developed after an anatomical investigation of cadavers to identify the sphenomandibular muscle as an independent entity. The objective here was to perform a clinical and interpretative evaluation of the physiological relationships between the functions of the sphenomandibular muscle and various symptoms, thereby associating temporomandibular disorders with ocular pain. Ten anatomical sets (fi ve cadavers in the Department of Anatomy of the Medicine School of the Catholic University of Goiás were examined. This study was conducted between April, 2006 and December, 2008. Patients (181 subjects suffering from temporomandibular disorder were treated in the Federal University of Goiás Dental School. Two groups were compared: Group I consisted of 58 patients with temporomandibular disorder, referred ocular pain, and hyperactivity of the sphenomandibular muscles; Group II was comprised of 45 patients with temporomandibular disorder, ocular pain, but no hyperactivity of the sphenomandibular muscles. After a clinical exam, treatments were conducted with semi-yearly follow-up exams for 2 years. Responses to the treatment were evaluated by questionnaires thereby quantifying existing levels of ocular pain. Pain was eliminated in 46 of the 58 patients in Group I (79.31% and 8 of the 45 patients in Group II (17.77%. Our evaluation affi rms that the sphenomandibular muscle, independent of the temporal muscle, has an intimate relationship with the orbit. The clinical exam allowed an evaluation of the sphenomandibular muscles in temporomandibular disorder episodes. The hyperactivity of the sphenomandibular muscle is thus signifi cantly related to the presence of ocular-referred pain (p < 0.05.

  4. Complicações oftálmicas em pacientes com tumores malignos extra-orbitários Ophthalmic complications in patients with extraorbital malignant tumors

    Directory of Open Access Journals (Sweden)

    Ana Célia Baptista

    2003-10-01

    Full Text Available OBJETIVO: Correlacionar as complicações oftálmicas, presentes em pacientes portadores de tumores malignos extra-orbitários, com o sítio de origem e diagnóstico histopatológico destas neoplasias, por meio de tomografia computadorizada. MÉTODOS: Foram estudados retrospectivamente, por tomografia computadorizada, 29 pacientes com neoplasias malignas extra-orbitárias, sem qualquer tratamento prévio do tumor, e evidência clínico-radiológica de comprometimento orbitário associado. RESULTADOS: Houve predomínio do carcinoma epidermóide (28%, seguido pelo carcinoma basocelular (14%. As complicações oftálmicas mais comumente observadas foram proptose (38%, epífora (24% e dor ocular (24%. Redução da acuidade visual foi referida em 14 % dos casos. Os sítios de origem mais comuns das neoplasias foram o seio maxilar (28%, o seio etmoidal (17% e a pele e subcutâneo da face (17%. Proptose ocular foi causada predominantemente por tumores não carcinomatosos e tumores originados no seio etmoidal, ao passo que epífora ocorreu preferencialmente nos casos de tumores carcinomatosos e de neoplasias do seio maxilar. Redução da motilidade ocular, irritação ocular e secreção no olho foram as complicações oftálmicas mais freqüentes em pacientes com tumores dos anexos oculares, ao passo que dor ocular foi a complicação oftálmica dominante nos pacientes com neoplasias originadas na pele e subcutâneo da face. CONCLUSÕES: Os autores sugerem que, diante de paciente com epífora e massa maxilo-nasal, carcinoma do seio maxilar deve ser considerado primariamente no diagnóstico diferencial da lesão. Da mesma forma, tumores não carcinomatosos, como sarcomas e linfomas, devem ser considerados, sobretudo no diagnóstico de pacientes com proptose e massa naso-etmoidal.OBJECTIVE: To correlate the ophthalmic complications in patients with extra-orbital malignant tumors with the site of origin and histopathologic diagnosis of the tumors by

  5. [Recording cervical and ocular vestibular evoked myogenic potentials: part 1: anatomy, physiology, methods and normal findings].

    Science.gov (United States)

    Walther, L E; Hörmann, K; Pfaar, O

    2010-10-01

    Vestibular evoked myogenic potentials (VEMP) have gained in clinical significance in recent years, now forming an integral part of neurootological examinations to establish the functional status of the otolith organs. They are sensitive to low-frequency acoustic stimuli. When stimulated, receptors in the sacculus and utriculous are activated. By means of reflexive connections, myogenic potentials can be recorded when the relevant muscles are tonically activated. The vestibulocolic (sacculocollic) reflex travels from the otolith organs over the central circuitry to the ipsilateral sternocleidomastoid muscle. Myogenic potentials can be recorded by means of cervical VEMP (cVEMP). The vestibuloocular reflex crosses contralaterally to the extraocular eye muscle. Ocular VEMP (oVEMP) are recorded periocularly, preferably from the inferior oblique muscle. Various stimulation methods are used including air conduction and bone conduction.

  6. Ocular Complications of Inflammatory Bowel Disease

    Directory of Open Access Journals (Sweden)

    Rana Mady

    2015-01-01

    the usual intestinal manifestations, leading to an earlier diagnosis. Thus, it is important to understand the clinical presentation of possible ocular manifestations in order to initiate appropriate treatment and to help prevent significant visual morbidity.

  7. Update on ocular toxicity of ethambutol

    Directory of Open Access Journals (Sweden)

    Priscilla Makunyane

    2016-03-01

    Full Text Available The purpose of this review is to update clinicians on available literature on the ocular toxicity of ethambutol and the type of eye care to be provided to patients treated with these medications. Ethambutol is a commonly used first-line anti-tuberculosis drug. Since its first use in the 1960s, ocular toxicity is described as related to dose and duration, and it is reversible on therapy discontinuation. However, the reversibility of the toxic optic neuropathy remains controversial. The mechanism of ocular toxicity owing to ethambutol is still under investigation. Other than discontinuing the drug, no specific treatment is available for the optic neuropathy caused by ethambutol. Doctors prescribing ethambutol should be aware of the ocular toxicity, and the drug should be used with proper patient education and ophthalmic monitoring.

  8. Ocular manifestations in systemic lupus erythematosus.

    Science.gov (United States)

    Silpa-archa, Sukhum; Lee, Joan J; Foster, C Stephen

    2016-01-01

    Systemic lupus erythematosus (SLE) can involve many parts of the eye, including the eyelid, ocular adnexa, sclera, cornea, uvea, retina and optic nerve. Ocular manifestations of SLE are common and may lead to permanent blindness from the underlying disease or therapeutic side effects. Keratoconjunctivitis sicca is the most common manifestation. However, vision loss may result from involvement of the retina, choroid and optic nerve. Ocular symptoms are correlated to systemic disease activity and can present as an initial manifestation of SLE. The established treatment includes prompt systemic corticosteroids, steroid-sparing immunosuppressive drugs and biological agents. Local ocular therapies are options with promising efficacy. The early recognition of disease and treatment provides reduction of visual morbidity and mortality.

  9. [Ocular hypertension after surgery for retinal detachment].

    Science.gov (United States)

    Muşat, O; Cristescu, R; Coman, Corina; Asandi, R

    2012-01-01

    This papers presents a case of a patient with retinal detachement, 3 days ago operated (posterior vitrectomy internal tamponament with silicon oil 1000) who develop increased ocular pressure following silicon oil output in the anterior chamber.

  10. Ocular morbidity in leprosy patients with lagophthalmos.

    Science.gov (United States)

    Khandpur, S; Robertson, S J; Rao, P S S

    2009-01-01

    Lagophthalmos is a well known complication in leprosy due to the involvement of seventh cranial nerve resulting in incomplete closure of the eyelids. The real magnitude of ocular morbidity as a consequence of lagophthalmos is unknown, as several ocular complications can occur independently due to involvement of the fifth (trigeminal) nerve or due to secondary infection. Therefore, a study was designed to carefully examine the eyes of 100 consecutive leprosy patients with lagophthalmos seeking treatment at a leprosy referral centre in Delhi. Among the eyes examined, 145 had lagophthalmos. The symptomatology and anterior-posterior chamber morbidity in eyes with lagophthalmos were significantly higher as compared to unaffected eyes. Significantly, higher morbidity was seen regardless of sex or type of leprosy or deformity. Capacity building of the health professionals regarding ocular morbidity and increased emphasis on the importance of self care among patients can significantly reduce ocular morbidity.

  11. Ocular lesions in free-living raptors.

    Science.gov (United States)

    Murphy, C J; Kern, T J; McKeever, K; McKeever, L; MacCoy, D

    1982-12-01

    In a retrospective study, records of 931 raptors admitted to the Avian Clinic at the New York State College of Veterinary Medicine and to the Owl Rehabilitation Research Foundation were evaluated to determine the prevalence, cause, and distribution of ocular lesions. Some form of ocular lesion was identified in 135 (14.5%) birds. Of these, 90% were the result of physical injury. Collisions accounted for 33% of ocular lesions; gunshot wounds accounted for 11%. Unilateral lesions were more common than bilateral lesions, with the anterior segment being most frequently involved. Hyphema was the most common clinical finding. In a prospective study involving raptors admitted to the Avian Clinic from 1980-1982, it was found that 17 of 61 birds (28%) had some form of ocular lesion. The higher prevalence in this study was attributed to a lower proportion of juvenile cases and to increased detection of subtle lesions, especially those involving the posterior segment.

  12. Skeletal muscle

    Science.gov (United States)

    There are approximately 650-850 muscles in the human body these include skeletal (striated), smooth and cardiac muscle. The approximation is based on what some anatomists consider separate muscle or muscle systems. Muscles are classified based on their anatomy (striated vs. smooth) and if they are v...

  13. Role of the flocculus of the cerebellum in motor learning of the vestibulo-ocular reflex

    Science.gov (United States)

    Highstein, S. M.

    1998-01-01

    Structure-function studies at the systems level are an effective method for understanding the relationship of the central nervous system to behavior. Motor learning or adaptation of the vestibulo-ocular reflex is a clear example wherein this approach has been productive. During a vestibulo-ocular reflex the brain converts a head velocity signal, transduced through the vestibular semicircular canals, into an eye movement command delivered to the extraocular muscles. If the viewed target remains on the fovea of the retina, the reflex is compensatory, and its gain, eye velocity/head velocity, is one. When the image of the viewed object slips across the retina, visual acuity decreases, and the gain of the reflex, which is no longer one, is plastically adapted or adjusted until retinal stability is restored. The anatomic substrate for this plasticity thus involves brain structures in which visual-vestibular interaction can potentially occur, as well as vestibular and visual sensory and oculomotor motor structures. Further, it has been known for many years that removal of the flocculus of the cerebellum permanently precludes further vestibulo-ocular reflex adaptation, demonstrating the involvement of the cerebellum in this behavior. Maekawa and Simpson (J Neurophysiol 1973;36: 649-66) discovered that one visual input to the flocculus involved the accessory optic system and the inferior olive. Ensuing work has demonstrated that the visual signals used to adapt the vestibulo-ocular reflex are transmitted by this accessory optic system to the flocculus and subsequently to brain stem structures involved in vestibulo-ocular reflex plasticity. Presently the inclusive list of anatomic sites involved in vestibulo-ocular reflex circuitry and its adaptive plasticity is small. Our laboratory continues to believe that this behavior should be caused by interactions within this small class of neurons. By studying each class of identified neuron and its interactions with others within

  14. Cisticercosis ocular Ocular cysticercosis: presentation of one case

    Directory of Open Access Journals (Sweden)

    David Botero

    1992-01-01

    Full Text Available

    Se presenta el caso de un paciente con un cisticerco retiniano, tratado sin éxito con praziquantel, quien a los cinco meses del tratamiento presentó fibrosis y desprendimiento de la retina. Se realizó intervención quirúrgica y se encontró el cisticerco vivo. Desde antes de la operación el paciente había perdido la visión por el ojo afectado. Se hace una revisión sobre oftalmocisticercosis y se recomienda tratamiento quirúrgico oportuno y no usar los antihelmínticos con efecto sobre los cisticercos, como son praziquantel y albendazol.

    One case of ocular cysticercosis with retinal involvement, in which praziquantel treatment was ineffective, is presented. Five months after the medical treatment the patient presented with retinal detachment and fibrosis, loss of vision through the affected eye and at that time the parasite was observed alive. Surgical intervention was performed and the recovered cysticercus showed viability. A review on ophtalmocysticercosis is presented and recommendations are made to treat these cases by early surgery without prior administration of anticysticercus drugs such as praziquantel or albendazole.

  15. Prosthetic management of an ocular defect

    Directory of Open Access Journals (Sweden)

    Siddesh Kumar Chintal

    2010-01-01

    Full Text Available The disfigurement associated with the loss of an eye can cause significant physical and emotional problems. Various treatment modalities are available, one of which is implants. Although implant has a superior outcome, it may not be advisable in all patients due to economic factors. The present article describes the prosthetic management of an ocular defect with a custom-made ocular prosthesis.

  16. A case report of ocular toxocariasis

    Institute of Scientific and Technical Information of China (English)

    Azira NMS; Zeehaida M

    2011-01-01

    Ocular toxocariasis is prevalent among children. The symptoms and signs may mimic other ocular pathologies such as malignancies and other infectious diseases (such as toxoplasmosis and syphilis). We presented a case of progressive blurring of vision in a single eye of a9-year-old boy. The presence of anti-toxocara antibody in serum samples helps to confirmation the diagnosis in our patient. Despite of treatment, the boy had lost his vision on the affected eye.

  17. A case report of ocular toxocariasis

    Directory of Open Access Journals (Sweden)

    NMS Azira

    2011-04-01

    Full Text Available Ocular toxocariasis is prevalent among children. The symptoms and signs may mimic other ocular pathologies such as malignancies and other infectious diseases (such as toxoplasmosis and syphilis. We presented a case of progressive blurring of vision in a single eye of a 9-year-old boy. The presence of anti-toxocara antibody in serum samples helps to confirmation the diagnosis in our patient. Despite of treatment, the boy had lost his vision on the affected eye.

  18. Study of Ocular Changes in Pregnancy

    OpenAIRE

    O K Radhakrishnan; Debapriya Datta; Jyoti Yadav; Priti Kumari; Vasundhara Phillips; Nimrita Nagdev

    2016-01-01

    Introduction: In pregnancy, women undergo a tremendous number of systemic and ocular changes. Physiological changes occur in the cardiovascular, hormonal, metabolic, hematologic and immunologic systems. Hormonal changes are among the most prominent systemic changes in pregnant women with the placenta, maternal endocrine glands and the fetal adrenal glands combining their productivity to make a high-powered hormone factory. Aims: To evaluate the various ocular changes taking place in pregnancy...

  19. Study of Ocular Changes in Pregnancy

    OpenAIRE

    O K Radhakrishnan; Debapriya Datta; Jyoti Yadav; Priti Kumari; Vasundhara Phillips; Nimrita Nagdev

    2016-01-01

    Introduction: In pregnancy, women undergo a tremendous number of systemic and ocular changes. Physiological changes occur in the cardiovascular, hormonal, metabolic, hematologic and immunologic systems. Hormonal changes are among the most prominent systemic changes in pregnant women with the placenta, maternal endocrine glands and the fetal adrenal glands combining their productivity to make a high-powered hormone factory. Aims: To evaluate the various ocular changes taking place in pregnancy...

  20. Ocular teratogens: old acquaintances and new dangers.

    Science.gov (United States)

    Tandon, A; Mulvihill, A

    2009-06-01

    Recent research into animal studies has contributed significantly to understanding the pathophysiology of some well-known teratogens, such as alcohol. Techniques, such as positron emission tomography (PET) and retinal synaptogenesis studies, have helped determine the specific areas in the developing brain and ocular structures, which are targeted by various teratogens. In this article, we also highlight a few newer agents, such as benzodiazepines, with potential for ocular malformation and morbidity in the developing foetus.

  1. Extra-oral halitosis: an overview.

    Science.gov (United States)

    Tangerman, A; Winkel, E G

    2010-03-01

    Halitosis can be subdivided into intra-oral and extra-oral halitosis, depending on the place where it originates. Most reports now agree that the most frequent sources of halitosis exist within the oral cavity and include bacterial reservoirs such as the dorsum of the tongue, saliva and periodontal pockets, where anaerobic bacteria degrade sulfur-containing amino acids to produce the foul smelling volatile sulfur compounds (VSCs), especially hydrogen sulfide (H(2)S) and methyl mercaptan (CH(3)SH). Tongue coating is considered to be the most important source of VSCs. Oral malodor can now be treated effectively. Special attention in this overview is given to extra-oral halitosis. Extra-oral halitosis can be subdivided into non-blood-borne halitosis, such as halitosis from the upper respiratory tract including the nose and from the lower respiratory tract, and blood-borne halitosis. The majority of patients with extra-oral halitosis have blood-borne halitosis. Blood-borne halitosis is also frequently caused by odorous VSCs, in particular dimethyl sulfide (CH3SCH3). Extra-oral halitosis, covering about 5-10% of all cases of halitosis, might be a manifestation of a serious disease for which treatment is much more complicated than for intra-oral halitosis. It is therefore of utmost importance to differentiate between intra-oral and extra-oral halitosis. Differences between intra-oral and extra-oral halitosis are discussed extensively. The importance of applying odor characterization of various odorants in halitosis research is also highlighted in this article. The use of the odor index, odor threshold values and simulation of bad breath samples is explained.

  2. Antibiotic resistance in ocular bacterial pathogens

    Directory of Open Access Journals (Sweden)

    S Sharma

    2011-01-01

    Full Text Available Bacterial infections of the eye are common and ophthalmologists are spoilt for choice with a variety of antibiotics available in the market. Antibiotics can be administered in the eye by a number of routes; topical, subconjunctival, subtenon and intraocular. Apart from a gamut of eye drops available, ophthalmologists also have the option of preparing fortified eye drops from parenteral formulations, thereby, achieving high concentrations; often much above the minimum inhibitory concentration (MIC, of antibiotics in ocular tissues during therapy. Antibiotic resistance among ocular pathogens is increasing in parallel with the increase seen over the years in bacteria associated with systemic infections. Although it is believed that the rise in resistant ocular bacterial isolates is linked to the rise in resistant systemic pathogens, recent evidence has correlated the emergence of resistant bacteria in the eye to prior topical antibiotic therapy. One would like to believe that either of these contributes to the emergence of resistance to antibiotics among ocular pathogens. Until recently, ocular pathogens resistant to fluoroquinolones have been minimal but the pattern is currently alarming. The new 8-fluoroquinolone on the scene-besifloxacin, is developed exclusively for ophthalmic use and it is hoped that it will escape the selective pressure for resistance because of lack of systemic use. In addition to development of new antibacterial agents, the strategies to halt or control further development of resistant ocular pathogens should always include judicious use of antibiotics in the treatment of human, animal or plant diseases.

  3. Muscle Deoxygenation Causes Muscle Fatigue

    Science.gov (United States)

    Murthy, G.; Hargens, A. R.; Lehman, S.; Rempel, D.

    1999-01-01

    Muscle fatigue is a common musculoskeletal disorder in the work place, and may be a harbinger for more disabling cumulative trauma disorders. Although the cause of fatigue is multifactorial, reduced blood flow and muscle oxygenation may be the primary factor in causing muscle fatigue during low intensity muscle exertion. Muscle fatigue is defined as a reduction in muscle force production, and also occurs among astronauts who are subjected to postural constraints while performing lengthy, repetitive tasks. The objectives of this research are to: 1) develop an objective tool to study the role of decreased muscle oxygenation on muscle force production, and 2) to evaluate muscle fatigue during prolonged glovebox work.

  4. Muscle disorder

    Science.gov (United States)

    Myopathic changes; Myopathy; Muscle problem ... Blood tests sometimes show abnormally high muscle enzymes. If a muscle disorder might also affect other family members, genetic testing may be done. When someone has symptoms and signs ...

  5. Dark Energy as Evidence for Extra Dimensions

    CERN Document Server

    Milton, K A

    2003-01-01

    It is argued that fluctuations of quantum fields in four-dimensional space do not give rise to dark energy, but are rather a negligible contribution to dark matter. By (relativistic) dark matter we mean that the relation between pressure and energy density is $p=\\frac13 u$, while dark energy is characterized by $p=-u$. A possible source of dark energy are the fluctuations in quantum fields, including quantum gravity, inhabiting extra compactified dimensions. These fluctuations have been computed for some simple geometries, such as $S^2$, $S^4$, and $S^6$. If the extra dimensions are too small, they would give rise to a dark energy larger than that observed, whereas if they are too large they would be in conflict with experimental tests of Newton's law. This notion suggests that the size of the extra dimensions is of order 100 $\\mu$m. If the limit on the size of extra dimensions becomes lower than this bound, extra dimensions probably do not exist, and another source for cosmological dark energy will have to b...

  6. Ocular biometric changes after trabeculectomy

    Directory of Open Access Journals (Sweden)

    Azam Alvani

    2016-01-01

    Full Text Available This review article aimed to evaluate ocular biometric changes after trabeculectomy. The PubMed database was searched using the keywords “axial length” (AL, “anterior chamber depth” (ACD, “corneal astigmatism,” “corneal topography” and “trabeculectomy.” The extracted studies were categorized based on the evaluated parameters and the biometry method (contact and non-contact. Comparable studies with respect to their sample size were combined for statistical analysis. Twenty-five studies including 690 individuals which met the inclusion criteria were selected. After trabeculectomy, a significant and persistent AL reduction, with a range of 0.1-0.19 and 0.1-0.9 mm measured with contact and non-contact methods, respectively, was observed. With respect to topographic changes, 0.38-1.4 diopters (D with-the-rule (WTR astigmatism was induced postoperatively. All studies revealed ACD reduction immediately after surgery, which gradually deepened and approximated its preoperative levels on day 14. ACD reduction was not significant after that period in the majority of cases. In conclusion, changes in ACD is of small amount and of short period, thus it can be ignored; however, reported changes in AL and keratometry are of sufficient magnitude and can affect the refractive prediction of combined cataract surgery and trabeculectomy.

  7. Ocular manifestations of pigmentary disorders.

    Science.gov (United States)

    Park, S; Albert, D M; Bolognia, J L

    1992-07-01

    Disorders of pigmentation can result from either an abnormal number of melanocytes, as in nevus of Ota and vitiligo, or an abnormal amount of melanin production, as in albinism. Melanin-producing cells are found in the skin, mucous membranes, uveal tract, and retinal pigment epithelium of the eye and the stria vascularis of the inner ear. Thus, many of the hereditary or congenital pigmentary disorders of the skin are associated with similar pigmentary abnormalities in the eye, such as iris heterochromia or changes in pigmentation of the fundus; however, more commonly, the associated eye finding is a defect in ocular motility, i.e., strabismus and nystagmus, suggesting a concomitant defect in neurologic development. In albinos, the observed neurologic abnormality in the visual pathway and foveal hypoplasia are hypothesized to be related directly to the lack of melanin in the pigment epithelium during development. In acquired disorders of pigmentation, in particular, vitiligo, Vogt-Koyanagi-Harada syndrome, and onchocerciasis, there is a frequent association with uveitis, suggesting an inflammatory cause for the cutaneous pigmentary changes.

  8. Ocular microtremor laser speckle metrology

    Science.gov (United States)

    Al-Kalbani, M.; Mihaylova, E.; Collins, N.; Toal, V.; Coakley, D.; Boyle, G.

    2009-02-01

    Ocular Microtremor (OMT) is a continual, high frequency physiological tremor of the eye present in all subjects even when the eye is apparently at rest. OMT causes a peak to peak displacement of around 150nm-2500nm with a broadband frequency spectrum between 30Hz to 120Hz; with a peak at about 83Hz. OMT carries useful clinical information on depth of consciousness and on some neurological disorders. Nearly all quantitative clinical investigations have been based on OMT measurements using an eye contacting piezoelectric probe which has low clinical acceptability. Laser speckle metrology is a candidate for a high resolution, non-contacting, compact, portable OMT measurement technique. However, tear flow and biospeckle might be expected to interfere with the displacement information carried by the speckle. The paper investigates the properties of the scattered speckle of laser light (λ = 632.8nm) from the eye sclera to assess the feasibility of using speckle techniques to measure OMT such as the speckle correlation. The investigation is carried using a high speed CMOS video camera adequate to capture the high frequency of the tremor. The investigation is supported by studies using an eye movement simulator (a bovine sclera driven by piezoelectric bimorphs). The speckle contrast and the frame to frame spatiotemporal variations are analyzed to determine if the OMT characteristics are detectable within speckle changes induced by the biospeckle or other movements.

  9. Categorical evaluation of the ocular irritancy of cosmetic and consumer products by human ocular instillation procedures.

    Science.gov (United States)

    Gao, Yang; Kanengiser, Bruce E

    2004-01-01

    The assessment of ocular irritation potential is an important part of safety testing for cosmetic and consumer products. The purpose of this investigation was to examine ocular irritancy levels elicited in humans by various categories of a specific class of cosmetic and consumer products that have a potential to enter the eye inadvertently during use. Test materials assessed belonged to one of seven categories, which included liquid makeup, shampoo, baby wash, mascara, eye makeup remover, powder eye shadow, and facial cleanser. These test materials were evaluated by human ocular instillation, followed by examinations, for which subjective perceptions of irritation were recorded, and component areas of ocular tissues were individually examined for inflammation and for the area and density of fluorescein staining patterns at 30 seconds and at 5, 15, 60, and 120 minutes post-instillation. Subjective and objective ocular irritation scores of 410 eyes were analyzed by product classification. Average score levels were determined for subjective responses, inflammation, and fluorescein staining patterns. This investigation determined that irritation levels of the evaluated test materials varied markedly with respect to product category, type of ocular irritation, and ocular tissue, demonstrating that these factors are important considerations for the prediction of the ocular irritancy of a test material.

  10. AGN 191976: a novel thromboxane A2-mimetic with ocular hypotensive properties.

    Science.gov (United States)

    Krauss, A H; Woodward, D F; Chen, J; Gibson, L L; Lai, R K; Protzman, C E; Shan, T; Williams, L S; Gac, T S; Burk, R M

    1995-01-01

    The possible subdivision of thromboxane A2-sensitive (TP) receptors is currently a controversial subject. We report herein on a novel thromboxane A2 mimetic, AGN 191976, which has almost identical pharmacological activity to the well-characterized prostaglandin H2/thromboxane A2 (PGH2/TxA2) mimetic U-46619, but its effects on intraocular pressure are quite distinct from U-46619. Prostanoid receptor activity was determined in vitro using different smooth muscle assays and platelets. Intraocular pressure was measured tonometrically in ocular normotensive Beagle dogs and Cynomolgus monkeys. Conjunctival microvascular permeability was determined in guinea pigs. Despite closely resembling U-46619 as a potent and selective TP receptor agonist, AGN 191976 was a potent ocular hypotensive in dogs and monkeys whereas U-46619 did not lower IOP in either species. The ocular hypotensive effect of AGN 191976 in dogs was attenuated by pretreatment with the TP receptor antagonist SQ 29548. Thus, the ocular hypotensive effects of AGN 191976 are consistent with TP receptor stimulation. Both TxA2-mimetics caused plasma leakage in the guinea pig conjunctiva. The disparate activities of U-46619 and AGN 191976 in our studies suggest the existence of heterogeneous populations of TP-receptors in the eye.

  11. Compact Extra Dimensions in Quantum Mechanics

    CERN Document Server

    Deutschmann, Nicolas

    2016-01-01

    Extra-dimensions are a common topic in popular descriptions of theoretical physics with which undergraduate student most often have no contact in physics courses. This paper shows how students could be introduced to this topic by presenting an approach to two basic consequences of the presence of compact extra-dimensions based on undergraduate-level physics. The insensibility of low-energy physics to compact extra dimensions is illustrated in the context of non-relativistic quantum mechanics and the prediction of Kaluza-Klein excitations of particles is discussed in the framework of relativistic wave-equations. An exercise that could be used as a follow-up to the "particle in a box" is proposed.

  12. Extra-dimensional models on the lattice

    CERN Document Server

    Knechtli, Francesco

    2016-01-01

    In this review we summarize the ongoing effort to study extra-dimensional gauge theories with lattice simulations. In these models the Higgs field is identified with extra-dimensional components of the gauge field. The Higgs potential is generated by quantum corrections and is protected from divergencies by the higher dimensional gauge symmetry. Dimensional reduction to four dimensions can occur through compactification or localization. Gauge-Higgs unification models are often studied using perturbation theory. Numerical lattice simulations are used to go beyond these perturbative expectations and to include non-perturbative effects. We describe the known perturbative predictions and their fate in the strongly-coupled regime for various extra-dimensional models.

  13. Extra-pulmonary manifestations of sarcoidosis

    Energy Technology Data Exchange (ETDEWEB)

    Vardhanabhuti, V. [Radiology Department, Derriford Hospital, Plymouth (United Kingdom); Venkatanarasimha, N. [St Michael' s Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8 (Canada); Bhatnagar, G.; Maviki, M.; Iyengar, S.; Adams, W.M. [Radiology Department, Derriford Hospital, Plymouth (United Kingdom); Suresh, P., E-mail: sureshpriya2000@yahoo.com [Radiology Department, Derriford Hospital, Plymouth (United Kingdom)

    2012-03-15

    Although, the diagnosis and evaluation of sarcoidosis has traditionally remained confined to the chest, its multi-system nature has been widely recognized. Radiological features of pulmonary sarcoidosis are well known but extra-pulmonary manifestations can produce a plethora of non-specific imaging findings that can affect subcutaneous tissue, and the neurological, cardiac, gastrointestinal, urological, liver, spleen, and skeletal systems. In the literature, there are various case reports and specific system reviews but there are few reviews that encompass all the extra-pulmonary manifestations. In this paper, we comprehensively review the imaging features of extra-pulmonary sarcoidosis with characteristic features as well as atypical presentations. In addition, we discuss the emerging role of nuclear medicine in sarcoidosis.

  14. Estudio sobre traumatismos oculares Study on ocular traumas

    Directory of Open Access Journals (Sweden)

    Ileana Miguel Pérez

    2004-06-01

    Full Text Available Se realizó estudio retrospectivo longitudinal de pacientes con traumatismos oculares mecánicos hospitalizados en el Instituto Superior de Medicina Militar "Dr. Luis Díaz Soto", desde 1988 hasta el 2002, con una casuística de 508 ojos de 479 pacientes. El procesamiento estadístico fue realizado con el mismo programa automatizado con el que se conformó la base de datos (Acces y se utilizaron de acuerdo con las características de las variables ß analizadas métodos estadísticos paramétricos y no paramétricos con una confiabilidad de un 95 % (a =0,05. Se obtiene una relación de 4:1 de predominio del sexo masculino, con una edad promedio de 27,4 años con valor mínimo de 2 años y máximo de 78 años. Los mecanismos más frecuentes de producción del accidente resultaron ser: las armas de fuego (22,7 % y la acción de martillar (21,4 %, teniendo en cuenta que el 38,2 % de los pacientes fueron militares. Las lesiones asociadas a los traumatismos más frecuentes resultaron ser el hipema y el hemovítreo, y se demostró que a medida que eran mayores disminuía considerablemente la agudeza visual final. Los traumatismos cerrados (41,3 % fueron más frecuentes y tuvieron mejores resultados visuales finales (66,7 % con visión mayor de 0.1 que el resto de los grupos de traumatismos abiertos (herida simple, contusión-herida, herida con CEIO y contusión-herida con CEIO. Las contusiones-heridas con CEIO fueron provocados en su mayoría por las armas de fuego y tuvieron los peores resultados visuales (60,5 % con visión menor de 0.1. La afectación del segmento posterior resultó ser un elemento que influyó de forma importante en los resultados visuales. Las complicaciones más frecuentes para los traumatismos cerrados fueron la hipertensión secundaria la catarata y el desprendimiento de retina. Para las heridas simples la catarata y para el resto de los traumatismos el desprendimiento de retina y la ptisis bulbi. Aproximadamente el 15 % de

  15. Study of Ocular Changes in Pregnancy

    Directory of Open Access Journals (Sweden)

    O K Radhakrishnan

    2016-03-01

    Full Text Available Introduction: In pregnancy, women undergo a tremendous number of systemic and ocular changes. Physiological changes occur in the cardiovascular, hormonal, metabolic, hematologic and immunologic systems. Hormonal changes are among the most prominent systemic changes in pregnant women with the placenta, maternal endocrine glands and the fetal adrenal glands combining their productivity to make a high-powered hormone factory. Aims: To evaluate the various ocular changes taking place in pregnancy in women with no other co-morbid ocular or systemic diseases and to compare ocular changes in three trimesters of pregnancy with controls of non pregnant women. Materials and Methods: The ocular changes occuring in varying stages of pregnancy in 225 pregnant women were studied and compared with 75 healthy non pregnant women. Results: Age was similar in the pregnant and non pregnant women studied. Headache was significantly more common among pregnant women when compared to non pregnant women. Diplopia was not significantly different between pregnant and non pregnant women. Intraocular pressure was significantly less among the pregnant women as compared to non pregnant women. Occurrence of conjunctival pigmentation was significantly more in pregnant women when compared to non pregnant women. There was no difference in corneal thickness when pregnant and non pregnant women were compared. Krukenberg's spindles were seen more commonly among pregnant women when compared to non pregnant women. Conclusion: Various ocular changes occur during a normal pregnancy. Knowledge of these changes can help to differentiate the physiological changes occurring in a normal pregnancy from ocular manifestation of systemic diseases. [Natl J Med Res 2016; 6(1.000: 1-4

  16. Mediation of supersymmetry breaking in extra dimensions

    CERN Document Server

    Scrucca, C A

    2004-01-01

    I review the mechanisms of supersymmetry breaking mediation that occur in sequestered models, where the visible and the hidden sectors are separated by an extra dimension and communicate only via gravitational interactions. By locality, soft breaking terms are forbidden at the classical level and reliably computable within an effective field theory approach at the quantum level. I present a self-contained discussion of these radiative gravitational effects and the resulting pattern of soft masses, and give an overview of realistic model building based on this set-up. I consider both flat and warped extra dimensions, as well as the possibility that there be localized kinetic terms for the gravitational fields.

  17. Electromagnetism from extra space multi connectivity

    Energy Technology Data Exchange (ETDEWEB)

    Gauthier, C. [Moncton Univ., Moncton (France). Dept. de Mathematiques et de Statistique

    2001-09-01

    In a unified field theory of the Kaluza-Klein type, it is used a multi connected extra space to interpret geometrically the quantum properties of physics. This paper presents a pure geometric interpretation of electromagnetism. The electric change of a body is identified with its cross-section for interaction of twisted waves due to the extra space multi connectivity. A by-product of this interpretation is an expression for the permittivity of free space as an integral of the flux of these waves over their frequencies.

  18. Signatures of extra dimensional sterile neutrinos

    Directory of Open Access Journals (Sweden)

    Werner Rodejohann

    2014-10-01

    Full Text Available We study a large extra dimension model with active and sterile Dirac neutrinos. The sterile neutrino masses stem from compactification of an extra dimension with radius R and are chosen to have masses around eV or keV, in order to explain short-baseline anomalies or act as warm dark matter candidates. We study the effect of the sterile neutrino Kaluza–Klein tower in short-baseline oscillation experiments and in the beta spectrum as measurable by KATRIN-like experiments.

  19. Signatures of extra dimensional sterile neutrinos

    Energy Technology Data Exchange (ETDEWEB)

    Rodejohann, Werner, E-mail: werner.rodejohann@mpi-hd.mpg.de; Zhang, He, E-mail: he.zhang@mpi-hd.mpg.de

    2014-10-07

    We study a large extra dimension model with active and sterile Dirac neutrinos. The sterile neutrino masses stem from compactification of an extra dimension with radius R and are chosen to have masses around eV or keV, in order to explain short-baseline anomalies or act as warm dark matter candidates. We study the effect of the sterile neutrino Kaluza–Klein tower in short-baseline oscillation experiments and in the beta spectrum as measurable by KATRIN-like experiments.

  20. The Higgs Mechanism from an extra dimension

    CERN Document Server

    A., Yu

    2016-01-01

    The standard $SU(2) \\times U(1)$ fields are considered in 4D plus one extra compact dimension. As a result two basic effects are obtained. First, four Goldstone-like scalars are produced, three of them are used to create longitudinal modes of the $W,Z$ fields, while the fourth becomes the Higgs-like scalar. Second, $W$ and $Z$ get their masses from the extra compact dimension with the standard pattern of symmetry violation. The resulting theory has the same fields as in the standard model, but without the Higgs vacuum average. The properties of the new Higgs scalar and its interaction with fermions are briefly discussed.

  1. Phenomenology of symmetry breaking from extra dimensions

    CERN Document Server

    Alfaro, J; Gavela-Legazpi, Maria Belen; Rigolin, S; Salvatori, M

    2007-01-01

    Motivated by the electroweak hierarchy problem, we study the symmetry breaking pattern induced by a background magnetic flux living on extra dimensions, with the four-dimensional scalar fields being gauge boson components in full space. For SU(N) and two compact, toroidal, extra dimensions, we determine analytically the possible field configurations of stable vacua and their symmetries. From the four-dimensional point of view, the system responds dynamically to the magnetic background by an infinite chain of vacuum expectation values so as to reach a stable vacuum. The equivalence between flux compactification and constant boundary conditions - either Scherk-Schwarz or twisted - is established.

  2. Ocular changes in primary hypothyroidism

    Directory of Open Access Journals (Sweden)

    Pekel Hamiyet

    2009-12-01

    Full Text Available Abstract Background To determine the ocular changes related to hypothyrodism in newly diagnosed patients without orbitopathy. Findings Thirty-three patients diagnosed to have primary overt hypothyroidism were enrolled in the study. All subjects were assigned to underwent central corneal thickness (CCT, anterior chamber volume, depth and angle measurements with the Scheimpflug camera (Pentacam, Oculus and cup to disc ratio (C/D, mean retinal thickness and mean retinal nerve fiber layer (RNFL thickness measurements with optical coherence tomography (OCT in addition to ophthalmological examination preceeding the replacement therapy and at the 1st, 3rd and 6th months of treatment. The mean age of the patients included in the study were 40.58 ± 1.32 years. The thyroid hormone levels return to normal levels in all patients during the follow-up period, however the mean intraocular pressure (IOP revealed no significant change. The mean CCT was 538.05 ± 3.85 μ initially and demonstrated no statistically significant change as the anterior chamber volume, depth and angle measurements did. The mean C/D ratio was 0.29 ± 0.03 and the mean retinal thickness was 255.83 ± 19.49 μ initially and the treatment did not give rise to any significant change. The mean RNFL thickness was also stable during the control visits, so no statistically significant change was encountered. Conclusions Neither hypothyroidism, nor its replacement therapy gave rise to any change of IOP, CCT, anterior chamber parameters, RNFL, retinal thickness and C/D ratio.

  3. Ocular lesions and experimental choline deficiency Lesiones oculares y deficiencia experimental de colina

    Directory of Open Access Journals (Sweden)

    Georgina P. Ossani

    2006-10-01

    Full Text Available Previous studies have shown ocular haemorrhages in choline-deficient rats. The aim of this paper is to study further the relationship between ocular and renal lesions and biochemical alterations in rats fed a choline-deficient diet. Fifty one weanling male Wistar rats, were divided into two groups. Thirty one of them were fed a choline-deficient diet and the rest was fed a choline-supplemented diet ad libitum. Animals from both groups were killed between the fifth and the eighth day. Urea, creatinine and homocysteine concentrations in blood were determined. Eyes were used for light microscopy study; high resolution light microscopy and the study of the retina as "rétine a plat". Kidneys were studied by light microscopy. Choline-supplemented rats did not show ocular or renal lesion. Choline-deficient rats that showed renal lesions, tubular or cortical necrosis, did not always have ocular changes. There were no ocular changes in the only choline-deficient rat without renal lesion. The ocular changes consisted mainly in haemorrhage in both cameras and ciliary and vitreous bodies. Correlations between ocular and renal lesion (r=0.72, pEstudios previos han demostrado hemorragia ocular en ratas deficientes en colina. El objetivo de este trabajo es profundizar en la relación entre las alteraciones oculares, renales y bioquímicas en ratas deficientes en colina. Cincuenta y una ratas Wistar macho recién destetadas fueron divididas en dos grupos: treinta y una fueron alimentadas con una dieta colino deficiente y el resto con colina suplementada ad-libitum. Los animales de ambos grupos fueron sacrificados entre el quinto y el octavo día. Se midió la concentración de urea, creatinina y homocisteína en sangre. Los ojos fueron estudiados por microscopía de luz, microscopía óptica de alta resolución y para el estudio de la retina como retina plana. Los riñones fueron estudiados por microscopía de luz. Las ratas suplementadas con colina no

  4. Trauma ocular a globo abierto en zona I

    Directory of Open Access Journals (Sweden)

    Dunia Cruz Izquierdo

    Full Text Available El trauma ocular, a globo abierto o cerrado, ocasiona gran ansiedad al lesionado, ya que su pronóstico visual está en relación con la conducta médica en el servicio de urgencia. La conducta debe ser específica para cada caso y así minimizar las complicaciones que se presentan en estos pacientes como: catarata y glaucoma de muy difícil manejo. Se describe un paciente de 43 años de edad que sufrió un trauma vegetal a globo abierto en zona I, con una espina de Marabú en el ojo derecho hace 3 meses. Refirió disminución de la agudeza visual de movimiento de mano a un metro, lagrimeo y sensación de cuerpo extraño. Acude al Instituto "Ramón Pando Ferrer", con la herida corneal suturada en su provincia y catarata traumática. Se le realizó facoaspiración de cristalino, pupiloplastia, implante de lente intraocular de cámara posterior, con seguimiento a las 24 horas y al mes de operado. El paciente alcanzó una agudeza visual con corrección óptica de 1,0 en la cartilla de Snellen al mes de operado.

  5. Ocular manifestations and treatment of congenital cataracts associated with microcornea

    Directory of Open Access Journals (Sweden)

    Yi-Xuan Zhao

    2014-04-01

    Full Text Available AIM: To report the clinical manifestation, curative opportunity and effect of congenital cataracts with microcornea.METHODS: The clinical materials of 18 eyes of 11 patients with microcorneas who underwent surgery for congenital cataracts from January 2000 to December 2012 were retrospectively analyzed. Preoperative examination including corneal diameter(RESULTS: The morphologic types of cataract were family history of congenital cataract(4 casesamong 11 patients. Other preoperative ocular abnormalities included aniridia(6 eyes, nystagmus(18 eyesand primary vitreous artery residues(1 eye. Totally 11 patients(18 eyeshad been performed the following three different types of operation: 1extra capsular extraction of cataract(ECCEwas performed in 5 eyes; 2ECCE for the first step and posterior chamber intraocular lens(PC-IOLfor the second step was performed in 4 eyes; 3ECCE and PC-IOL was performed in 9 eyes. Visual acuity was achieved after surgery, the best-corrected visual acuity(BCVAwas 0.145±0.0958(0.01-0.20. ECCE intraoperative complication was posterior capsule rupture(1 eye. The main postoperative complications were posterior capsular opacification(10 eyesand secondary glaucoma(2 eyes.CONCLUSION: The main complication in congenital cataracts with microcornea including aniridia, choroidal defect and nystagmus. IOL implantation can significantly improve visual acuity. Patients should pay attention to prevention corneal injury, posterior capsular rupture and etc. However, adequate management of postoperative complications, especially posterior capsular opacification and glaucoma is required.

  6. Ocular syphilis presenting as unilateral chorioretinitis

    Directory of Open Access Journals (Sweden)

    Anand Pai

    2012-01-01

    Full Text Available Syphilis is a multi systemic infection caused by Treponema pallidum. Ocular manifestations of Syphilis have a myriad of presentations and severity. A 31year old male patient was referred from ophthalmology department as a case of chorioretinitis for screening for syphilis. Patient had diminished vision and redness of right eye for 2 months duration. History of premarital exposure and extramarital contact was present. Ocular examination revealed - Rt eye: conjunctival congestion and Argyll Robertson pupil; Lt eye: normal. Fundoscopy of right eye showed yellowish white retinal lesions, macular edema and hyperaemia and left eye was normal .No genital lesion, scars or cutaneous lesion was present.VDRL was reactive in 1 dilution,TPHA was positive ; HIV test was negative ; CSF revealed VDRL - Negative and TPHA -Negative.Patient was treated with Injection procaine penicillin 1.2 Million units intramuscularly daily for 21 days. The patient responded well to treatment and there was improvement in his vision. Ocular Syphilis can occur at any stage of Syphilis and may be the only presenting sign. Syphilis serology was positive confirming the disease.This case highlights the importance of syphilis with ocular manifestation - there by proving that diagnosis of syphilis based on ocular finding is clinically challenging.

  7. [Ocular ischemic syndrome--a case report].

    Science.gov (United States)

    Zemba, M; Avram, Corina Ioana; Ochinciuc, Uliana; Stamate, Alina Cristina; Camburu, Raluca Lăcrămioara

    2013-01-01

    Ocular ischemic syndrome, also known as hypoperfusion/ hypotensive retinopathy or as ischemic oculopathy is a rare ocular disease determined by chronic arterial hypoperfusion through central retinal artery, posterior and anterior ciliary arteries. It is bilateral in 20% of the cases. Most often it appears due to severe occlusion of the carotid arteries (ICA, MCA>ECA), described in 1963 by Kearns and Hollenhorst. Occasionally it can be determined by the obstruction of ophtalmic artery or some arterities (Takayasu, giant cell arteritis). The risk factors are: age between 50-80 years, males (M:F = 2:1), arterial hypertension, diabetes, coronary diseases (5% of the cases develop ocular ischemic syndrome), vascular stroke, hemodialysis. The case we present is of an 63 years old man known with primary arterial hypertension, hypercholesterolemia, diabetes type 2 non insulin dependent and diagnosticated with ischemic cerebral stroke and bilateral obstruction of internal carotid arteries in march 2010, who is presenting for visual impairment in both eyes. The imaging investigations show important carotid occlusion and at the ophthalmologic evaluation there are ocular hypertension and rubeosis iridis at the right eye, optic atrophy at both eyes (complete in the right eye and partial in the left eye), with superior altitudinal visual field defect in left eye. The following diagnosis was established: Chronic ocular ischemic syndrome in both eyes with Neovascular glaucoma at the right eye, Anterior ischemic optic neuropathy at the left eye and laser panphotocoagulation at the right eye was started.

  8. Ocular manifestations of inflammatory bowel disease.

    Science.gov (United States)

    Thomas, Akshay S; Lin, Phoebe

    2016-11-01

    Extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) are numerous and can often involve the eye. This review highlights the ocular complications associated with IBD including the critical role the ophthalmologist can play in the diagnosis of IBD, the pathogenesis of IBD, its ocular complications, and the treatment of ocular inflammation associated with IBD. Polygenic and environmental influences, as well as gut microbial dysbiosis, have been implicated in the pathogenesis of IBD. IBD and its EIMs appear to respond well to TNFα-targeted biologics. IBD is thought to be caused by polygenic and environmental influences, including a dysbiotic gut microbiota. It is a systemic immune-mediated disease with varying types of ocular manifestations that can precede, occur simultaneously, or follow intestinal involvement. The diagnosis of IBD can be confused with other seronegative spondyloarthropathies as well as Behçet's disease. Treatment of IBD-associated ocular inflammation can range from corticosteroids to steroid-sparing immunosuppression such as azathioprine or methotrexate. Refractory disease can respond well to TNFα inhibitors.

  9. Ocular pharmacokinetics of thiamphenicol in rabbits.

    Science.gov (United States)

    Aldana, I; Fos, D; Gonzalez Peñas, E; Gazzaniga, A; Gianesello, V; Ceppi Monti, N; Figini, P G; Zato, M A; Bruseghini, L; Esteras, A

    1992-10-01

    The ocular pharmacokinetics of thiamphenicol (TAP, CAS 15318-45-3) was studied in rabbits by means of the assessment of its ocular and systemic absorption, and urinary excretion after instillation of 0.5% TAP eye drops. TAP concentrations in aqueous humor, plasma and urine were evaluated by a coupled LC/GC method (detection limit = 0.1 ng/ml), because the necessity to have a technique much more sensitive than the traditional chromatographic ones available in order to quantify the very low drug concentrations in biological fluids produced by the ocular treatment, and generally by a topical administration. The intravenous route was chosen as reference and allowed the absolute bioavailability to be estimated. TAP proved to be well absorbed through the cornea with the peak aqueous humor concentration of 110 ng/ml at 45 min following the instillation. The good ocular absorption of TAP was confirmed by the plasma concentrations observed after instillation of 0.5% eye drops. In any case, these concentrations were more than 1000 times lower than those observed after the intravenous treatment at the dose normally used for infectious diseases, allowing to exclude any systemic toxicity of TAP eye drops. The absolute ocular bioavailability was 16.2% when estimated from the AUC values and 34.0% from the cumulative urinary excretion values.

  10. Impacts of Nanomedicines in Ocular Pharmacotherapy

    Directory of Open Access Journals (Sweden)

    Jaleh Barar

    2011-06-01

    Full Text Available Introduction: The integrity of the cells/tissues in anterior and/or posterior segments of the eye plays a crucial role in biofunctions of the vision. To maintain ocular homeostasis, selective restrictiveness of the ophthalmic membranes and barriers control must act on shuttling of biomolecules. Thus, not all attempts to apply de novo nanotechnology approaches for ocular pharmacotherapy have met with the same successes as those cited here in this review, and sometimes these novel technologies tools provoke a great deal of challenges and hurdles mainly because of functional presence of these barriers. Methods: Recent published articles related to application of ocular nanomedicines were reviewed and highlighted in this review article. Results: It seems the emergence of nanomedicines have arisen great hopes for ophthalmic pharmacotherapy, in which nanostructured medicines are expected to be able to cross the restrictive barriers of the eye. Although such fast inauguration of ocular nanomedicines will literally convey new challenges in the regulatory and translational processes, it will also grant a prolific platform from which many exciting, and yet unimagined, applications of biomedical nanotechnology will emerge for pharmacotherapy of the eye. Conclusion: This review provide recent advancements on ocular nanomedicines.

  11. Ocular dermoid in Pai Syndrome: A review.

    Science.gov (United States)

    Tormey, Peter; Bilic Cace, Iva; Boyle, Michael A

    2017-04-01

    Pai Syndrome is a rare congenital malformation syndrome of unknown cause with hypertelorism, midline cleft lip, nasal and facial polyps, ocular anomalies and the presence of distinctive lipomas adjacent to the corpus callosum. Herein, we present an infant girl with Pai Syndrome diagnosed in the first week of life with typical facial findings and associated pericallosal lipoma identified on cranial ultrasound and brain MRI. These typical features identified included median cleft of the upper lip (in her case as a forme fruste) with a cleft alveolus and a mid-anterior alveolar process congenital polyp. In addition to these findings there was mild hypertelorism and an ocular abnormality on the right eye. An ophthalmology assessment on day 5 identified the ocular lesion as a limbal dermoid. Several ocular anomalies have been reported in association with Pai Syndrome, however, dermoids have not been frequently described in this Syndrome and not before in a limbal location. Increasing identification of previously unreported ocular abnormalities in Pai Syndrome may improve diagnosis and may prove useful in future work attempting to elucidate the aetiology of this rare syndrome.

  12. Ocular biomechanics study: current state and perspectives

    Directory of Open Access Journals (Sweden)

    S. Yu. Petrov

    2015-03-01

    Full Text Available Despite the fact that the eye represents a challenge for biomechanical research due to its size, over the last two decades, much data on ocular biomechanics were accumulated. Scleral and lamina cribrosa biomechanics contribute to our understanding of myopia and open-angle glaucoma; iris and trabecular meshwork biomechanics to that of angle-closure glaucoma; vitreous biomechanics to that of retinal detachment and ocular drug delivery; corneal biomechanics to that of keratoconus; and lens capsule biomechanics to that of cataract. This paper offers a general overview of recent advances in corneal, scleral, crystalline lens, and lamina cribrosa biomechanics and summarizes the results of experimental and clinical studies. Ocular biomechanics abnormalities affect etiology of many eye diseases. Ocular biomechanics plays an important role in the development of novel diagnostic methods, therapeutic and surgical procedures. Corneal biomechanics impacts etiology and pathogenesis of keratoconus as well as tonometry accuracy and explains corneal refractive surgery effect. Scleral biomechanics is associated with IOP and progressive myopia. Accommodative apparatus (ciliary body and crystalline lens is an important anatomic physiological structure. Recent studies uncovered the causes of agerelated loss of accommodation as a result of lens involution. Optic nerve head abnormalities due to IOP fluctuations are the key factor of glaucomatous neuropathy. They are directly associated with ocular biomechanics as well.

  13. Ocular biomechanics study: current state and perspectives

    Directory of Open Access Journals (Sweden)

    S. Yu. Petrov

    2015-01-01

    Full Text Available Despite the fact that the eye represents a challenge for biomechanical research due to its size, over the last two decades, much data on ocular biomechanics were accumulated. Scleral and lamina cribrosa biomechanics contribute to our understanding of myopia and open-angle glaucoma; iris and trabecular meshwork biomechanics to that of angle-closure glaucoma; vitreous biomechanics to that of retinal detachment and ocular drug delivery; corneal biomechanics to that of keratoconus; and lens capsule biomechanics to that of cataract. This paper offers a general overview of recent advances in corneal, scleral, crystalline lens, and lamina cribrosa biomechanics and summarizes the results of experimental and clinical studies. Ocular biomechanics abnormalities affect etiology of many eye diseases. Ocular biomechanics plays an important role in the development of novel diagnostic methods, therapeutic and surgical procedures. Corneal biomechanics impacts etiology and pathogenesis of keratoconus as well as tonometry accuracy and explains corneal refractive surgery effect. Scleral biomechanics is associated with IOP and progressive myopia. Accommodative apparatus (ciliary body and crystalline lens is an important anatomic physiological structure. Recent studies uncovered the causes of agerelated loss of accommodation as a result of lens involution. Optic nerve head abnormalities due to IOP fluctuations are the key factor of glaucomatous neuropathy. They are directly associated with ocular biomechanics as well.

  14. Extra-1 acupressure for children undergoing anesthesia.

    Science.gov (United States)

    Wang, Shu-Ming; Escalera, Sandra; Lin, Eric C; Maranets, Inna; Kain, Zeev N

    2008-09-01

    Acupuncture and related techniques have been used as adjuncts for perioperative anesthesia management. We examined whether acupressure in the Extra-1 (Yin-Tang) point would result in decreased preprocedural anxiety and reduced intraprocedural propofol requirements in a group of children undergoing endoscopic procedures. Fifty-two children were randomized to receive acupressure bead intervention either at the Extra-1 acupuncture point or at a sham point. A Bispectral Index (BIS) monitor was applied to all children before the onset of the intervention. Anxiety was assessed at baseline and before entrance to the operating room. Anesthetic techniques were standardized and maintained with IV propofol infusion titrated to keep BIS values of 40-60. We found that after the intervention, children in the Extra-1 group experienced reduced anxiety whereas children in the sham group experienced increased anxiety (-9% [-3 to -15] vs 2% [-6 to 7.4], P = 0.012). In contrast, no significant changes in BIS values were observed in the preprocedural waiting period between groups (P = ns). We also found that total intraprocedural propofol requirements did not differ between the two study groups (214 +/- 76 microg x kg(-1) x min(-1) vs 229 +/- 95 microg x kg(-1) x min(-1), P = 0.52). We conclude that acupressure bead intervention at Extra-1 acupoint reduces preprocedural anxiety in children undergoing endoscopic procedures. This intervention, however, has no impact on BIS values or intraprocedural propofol requirements.

  15. Gauge coupling unification with extra Higgs doublets

    Energy Technology Data Exchange (ETDEWEB)

    Harada, Junpei [Research Center for Higher Education, Health Sciences University of Hokkaido (Japan)

    2016-06-15

    Gauge coupling unification is studied within the framework where there are extra Higgs doublets and E{sub 6} exotic fields. Supersymmetric models and nonsupersymmetric models are investigated, and a catalog of models with gauge coupling unification is presented. (copyright 2016 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  16. Precision constraints on extra fermion generations.

    Science.gov (United States)

    Erler, Jens; Langacker, Paul

    2010-07-16

    There has been recent renewed interest in the possibility of additional fermion generations. At the same time there have been significant changes in the relevant electroweak precision constraints, in particular, in the interpretation of several of the low energy experiments. We summarize the various motivations for extra families and analyze them in view of the latest electroweak precision data.

  17. Probing Extra Dimensions with Neutrino Oscillations

    Energy Technology Data Exchange (ETDEWEB)

    Machado, P.A.N. [Instituto de Fisica, Universidade de Sao Paulo, C. P. 66.318, 05315-970 Sao Paulo (Brazil); Nunokawa, H. [Departamento de Fisica, Pontificia Universidade Catolica do Rio de Janeiro, C. P. 38071, 22452-970 Rio de Janeiro (Brazil); Zukanovich Funchal, R., E-mail: zukanov@fma.if.usp.br [Instituto de Fisica, Universidade de Sao Paulo, C. P. 66.318, 05315-970 Sao Paulo (Brazil)

    2011-08-15

    We consider a model where sterile neutrinos can propagate in a large compactified extra dimension (a) giving rise to Kaluza-Klein (KK) modes and the Standard Model left-handed neutrinos are confined to a 4-dimensional spacetime brane. The KK modes mix with the standard neutrinos modifying their oscillation pattern. We examine current experiments in this framework obtaining stringent limits on a.

  18. Extra-oral halitosis : an overview

    NARCIS (Netherlands)

    Tangerman, A.; Winkel, E. G.

    2010-01-01

    Halitosis can be subdivided into intra-oral and extra-oral halitosis, depending on the place where it originates. Most reports now agree that the most frequent sources of halitosis exist within the oral cavity and include bacterial reservoirs such as the dorsum of the tongue, saliva and periodontal

  19. Cystic lesions accompanying extra-axial tumours

    NARCIS (Netherlands)

    Lohle, PNM; Wurzer, HAL; Seelen, PJ; Kingma, LM; Go, KG

    1999-01-01

    We examined the mechanism of cyst formation in extra-axial tumours in the central nervous system (CNS). Cyst fluid, cerebrospinal fluid (CSF) and blood plasma were analysed in eight patients with nine peritumoral cysts: four with meningiomas, two with intracranial and two spinal intradural schwannom

  20. Extra dimensions and violations of Lorentz symmetry

    CERN Document Server

    Overduin, James M

    2016-01-01

    We use experimental limits on Lorentz violation to obtain new constraints on Kaluza-Klein-type theories in which the extra dimensions may be large but do not necessarily have units of length. The associated variation in fundamental quantities such as rest mass must occur slowly, on cosmological scales.

  1. The Night Of Hennessy Paradis Extra Cognac

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正>The world-known Hennessy Paradis Extra Cognaclaunched its"dazzling night"on the evening of May 22 tolet guests enjoy to their hearts’content the fine wine andthe charming glamour of the diamond evening dress. A liquid,dating back to the 18th century,was called

  2. A STUDY OF OCULAR MANIFESTATION IN PATIENTS OF RHEUMATIC ART H RITIS

    Directory of Open Access Journals (Sweden)

    Amit

    2015-10-01

    Full Text Available AIM: To prospectively screen all rheumatic arthritis patients to find out the prevalence of ocular manifestations including uveitis, dry eye syndromes, episcleritis, keratitis, scleritis. INTRODUCTION : R heumatic Diseases makes a base for the ophthalmologist to interface with both the patient and the internist. The expertise of t he ophthalmologist in determining the specific ocular tissue involved and the rheumatologist's knowledge of the systemic manifestations can not only facilitate the proper diagnosis but can also provide optimal care for these diseases of vision, which are o ften life - threatening. MATERIALS & METHODS : A random observational cross - sectional study was carried out among 30 patients with active Rheumatic Arthritis. All examined patients aged >13yrs were in I or II stage of disease according to criteria of The Amer ican College of Rheumatology. All patients were seropositive. Details of the clinical history including detailed articular and extra - articular manifestat ions like dry eyes, burning, it ching, FB sensation, photophobia, pain, redness, watering, dim i nution of vision & drug history were recorded. Thorough slit lamp examination of anterior and posterior segment of eyes along with visual acuity, IOP and Lacrimal function test - Sac syringing, Schirmer’s test, Tear BUT, r ose Bengal staining was done. Statistical a nalysis was performed by using SPSS 14.3 which in - volves paired and unpaired t - tests. Mean value and ±SD were calculated for each group and compared with other studies. P value 10yrs and RF titer >200. CONCLUSION : Females were far more commonly affected than males (86.6% owning to the immunological nature of the disease. Bilateral o cular involvement was much more common than unilateral as RA being a systemic disease. Occupation doesn’t have much effect on the incidence of Rheumatic Arthritis as much sex does and thence housewives were more commonly affected as stated. Most of the pat ients

  3. Pharmacological inhibition of GSK-3 in a guinea pig model of LPS-induced pulmonary inflammation : II. Effects on skeletal muscle atrophy

    NARCIS (Netherlands)

    Verhees, Koen J P; Pansters, Nicholas A M; Baarsma, Hoeke A; Remels, Alexander H V; Haegens, Astrid; de Theije, Chiel C; Schols, Annemie M W J; Gosens, Reinoud; Langen, Ramon C J

    2013-01-01

    BACKGROUND: Chronic obstructive pulmonary disease (COPD) is accompanied by pulmonary inflammation and associated with extra-pulmonary manifestations, including skeletal muscle atrophy. Glycogen synthase kinase-3 (GSK-3) has been implicated in the regulation of muscle protein- and myonuclear turnover

  4. Combined ocular and cervical vestibular evoked myogenic potential in individuals with vestibular hyporeflexia and in patients with Ménière's disease.

    Science.gov (United States)

    Silva, Tatiana Rocha; de Resende, Luciana Macedo; Santos, Marco Aurélio Rocha

    The vestibular evoked myogenic potential is a potential of mean latency that measures the muscle response to auditory stimulation. This potential can be generated from the contraction of the sternocleidomastoid muscle and also from the contraction of extraocular muscles in response to high-intensity sounds. This study presents a combined or simultaneous technique of cervical and ocular vestibular evoked myogenic potential in individuals with changes in the vestibular system, for use in otoneurologic diagnosis. To characterize the records and analyze the results of combined cervical and ocular VEMP in individuals with vestibular hyporeflexia and in those with Ménière's disease. The study included 120 subjects: 30 subjects with vestibular hyporeflexia, 30 with Ménière's disease, and 60 individuals with normal hearing. Data collection was performed by simultaneously recording the cervical and ocular vestibular evoked myogenic potential. There were differences between the study groups (individuals with vestibular hyporeflexia and individuals with Ménière's disease) and the control group for most of wave parameters in combined cervical and ocular vestibular evoked myogenic potential. For cervical vestibular evoked myogenic potential, it was observed that the prolongation of latency of the P13 and N23 waves was the most frequent finding in the group with vestibular hyporeflexia and in the group with Ménière's disease. For ocular vestibular evoked myogenic potential, prolonged latency of N10 and P15 waves was the most frequent finding in the study groups. Combined cervical and ocular vestibular evoked myogenic potential presented relevant results for individuals with vestibular hyporeflexia and for those with Ménière's disease. There were differences between the study groups and the control group for most of the wave parameters in combined cervical and ocular vestibular evoked myogenic potential. Copyright © 2016 Associação Brasileira de Otorrinolaringologia

  5. Treatment options for ocular adnexal lymphoma (OAL

    Directory of Open Access Journals (Sweden)

    Victoria Mary Lendrum Cohen

    2009-11-01

    Full Text Available Victoria Mary Lendrum CohenSt. Bartholomew’s and Moorfields Eye Hospital, London UKAbstract: Most lymphomas that involve the ocular adnexal structure are low grade, B cell, non-Hodgkin’s lymphomas. The treatment depends upon the grade and stage of the disease. High grade lymhoma requires treatment with systemic chemotherapy whereas the localized low grade (extranodal marginal zone lymphoma can be successfully managed with local radiotherapy. Chlamydia psittaci infection is associated with low grade ocular lymphoma; however there is wide geographic variation in the strength of this association. Blanket antibiotic therapy is not advised unless there is proof of an infective agent. The monoclonal antibody, rituximab, may be successful for CD20 positive lymphoma, although it is likely that rituximab will have better long-term results when used in combination with systemic chemotherapy.Keywords: ocular adnexal lymphoma, mucosa associated lymphoid tissue, extranodal marginal zone lymphoma, Chlamydia psittaci, rituximab, radiotherapy, chemotherapy

  6. Ocular immunopathologic findings of experimental onchocerciasis.

    Science.gov (United States)

    Donnelly, J J; Rockey, J H; Bianco, A E; Soulsby, E J

    1984-04-01

    Ocular immunopathologic responses of inbred guinea pigs infected with Onchocerca microfilariae from domesticated animals were studied as a laboratory model of human ocular onchocerciasis. A single intracorneal infection of normal guinea pigs with microfilariae produced only minimal ocular lesions. In contrast, intracorneal infection of guinea pigs previously immunized by systemic infection with microfilariae produced intense corneal and uveal inflammation. Transfer of splenic lymphocytes from immunized donors to syngeneic normal recipients substituted effectively for the active immunization. Cell recipients produced marked corneal inflammatory reactions when challenged by a single intracorneal infection. Fresh and cryopreserved microfilariae produced identical reactions. The corneal inflammatory infiltrates were composed primarily of eosinophils, neutrophils, and plasma cells and resembled human onchocercal keratitis. Diethylcarbamazine citrate administration after a challenge intracorneal infection increased the severity of the corneal inflammatory response in immunized animals.

  7. Recent Advances in Ocular Drug Delivery Systems

    Directory of Open Access Journals (Sweden)

    Shinobu Fujii

    2011-01-01

    Full Text Available Transport of drugs applied by traditional dosage forms is restricted to the eye, and therapeutic drug concentrations in the target tissues are not maintained for a long duration since the eyes are protected by a unique anatomy and physiology. For the treatment of the anterior segment of the eye, various droppable products to prolong the retention time on the ocular surface have been introduced in the market. On the other hand, direct intravitreal implants, using biodegradable or non-biodegradable polymer technology, have been widely investigated for the treatment of chronic vitreoretinal diseases. There is urgent need to develop ocular drug delivery systems which provide controlled release for the treatment of chronic diseases, and increase patient’s and doctor’s convenience to reduce the dosing frequency and invasive treatment. In this article, progress of ocular drug delivery systems under clinical trials and in late experimental stage is reviewed.

  8. Lymphocyte transformation in presumed ocular histoplasmosis

    Energy Technology Data Exchange (ETDEWEB)

    Ganley, J.P.; Nemo, G.J.; Comstock, G.W.; Brody, J.A.

    1981-08-01

    Lymphocytes from individuals with inactive macular disciform lesions of presumed ocular histoplasmosis challenged with three histoplasmin antigens incorporated tritiated thymidine at a significantly higher rate than histoplasmin-stimulated lymphocytes of matched control and peripheral scar groups. This finding is consistent with the etiologic association of the disciform ocular syndrome and previous systemic infection with Histoplasma capsulatum. The disciform group had a higher mean response than the other two groups to pokeweed mitogen but not to phytohemagglutinin and had higher mean counts per minute to the specific antigens Toxoplasma gondii, Blastomyces dermatitidis, Cryptococcus neoformans, Mycobacterium tuberculosis, M battery, and M gaus, but not to Candida albicans. These data would suggest that individuals with the disciform lesion of presumed ocular histoplasmosis have a hyperreactive cellular immune response; this response may play an important role in the development of the disciform.

  9. Ocular Fundus Photography as an Educational Tool.

    Science.gov (United States)

    Mackay, Devin D; Garza, Philip S

    2015-10-01

    The proficiency of nonophthalmologists with direct ophthalmoscopy is poor, which has prompted a search for alternative technologies to examine the ocular fundus. Although ocular fundus photography has existed for decades, its use has been traditionally restricted to ophthalmology clinical care settings and textbooks. Recent research has shown a role for nonmydriatic fundus photography in nonophthalmic settings, encouraging more widespread adoption of fundus photography technology. Recent studies have also affirmed the role of fundus photography as an adjunct or alternative to direct ophthalmoscopy in undergraduate medical education. In this review, the authors examine the use of ocular fundus photography as an educational tool and suggest future applications for this important technology. Novel applications of fundus photography as an educational tool have the potential to resurrect the dying art of funduscopy.

  10. Pediatric ocular trauma--a clinical presentation.

    Directory of Open Access Journals (Sweden)

    Dasgupta S

    1990-01-01

    Full Text Available A year long study of ocular injuries in children below the age of 15 years was conducted in the Ophthalmology Department of a general hospital. Fortyfour cases were studied. Of these 45.45% were in the age group of 6-10 years. The male to female ratio was 5.28 : 1. Pointed objects viz. sticks, wires etc. were found to be the common causative agents; the recent trend being of bow and arrow injuries. Ocular perforation was observed in 28 cases. On follow up of all the cases with ocular trauma, only 12 patients were found to have a visual acuity better than 6/18; perception of light was absent in 7 patients. A need for increased parental awareness and supervision of children is stressed upon.

  11. Cuerpo extraño intraocular. Presentación de un caso

    Directory of Open Access Journals (Sweden)

    Inés Zamora Galindo

    2012-05-01

    Full Text Available Los traumatismos oculares son una causa común de deficiencia visual, principalmente de ceguera monocular en el 33 al 40 % de los casos. Se presenta el caso de un paciente de 40 años y procedencia rural, que acudió a consulta de Oftalmología del Hospital General Universitario Dr. Gustavo Aldereguía Lima por presentar visión borrosa del ojo derecho, tres meses después de haber sufrido un traumatismo. Una correcta anamnesis, examen oftalmológico y métodos diagnósticos adecuados lograron la identificación de un cuerpo extraño intraocular. El paciente fue sometido a cirugía y evolucionó favorablemente; su agudeza visual mejor corregida es de 0,7 en el ojo derecho y de 1,0 en el izquierdo.

  12. [Ocular myositis as a rare cause of vision loss].

    Science.gov (United States)

    Rollnik, J D; Requadt, H

    2016-12-22

    Ocular myositis is a rare disease characterized by painful diplopia but loss of vision rarely occurs. The article reviews the literature focusing on the differential diagnostics. We report the case of an 80-year-old women suffering from slowly progressive loss of vision in the left eye. Diplopia was only present at the beginning and there was only moderate pain. Computed tomography and magnetic resonance imaging revealed a swelling of the left medial, lateral and inferior rectus muscles of the orbit leading to compression of the optic nerve in the orbital cone. An intravenous prednisolone stoss therapy (1000 mg per day for 3 consecutive days) was initiated, followed by oral medication of 100 mg per day then tapering over 10 weeks. Vision improved and no relapses were observed. Physicians should be aware of this rare disease to ensure quick diagnosis and treatment of ocular myositis.

  13. Pattern of ocular trauma seen in Grarbet Hospital, Butajira, Central ...

    African Journals Online (AJOL)

    Bernt Lindtjorn

    Objective: To evaluate the epidemiology and outcome of ocular trauma cases presented to Grarbet Hospital in central. Ethiopia .... unknown. Alcohol or drug abuse leading to ocular injury ..... childhood: demography, etiology, and prevention.

  14. [Ocular perfusion pressure and its relevance for glaucoma].

    Science.gov (United States)

    Schmidl, D; Werkmeister, R; Garhöfer, G; Schmetterer, L

    2015-02-01

    Ocular perfusion pressure is defined as the difference between arterial and venous pressure in ocular vessels. In practice, mean arterial pressure is used to substitute for arterial pressure in ocular vessels while intraocular pressure gives an estimate for ocular venous pressure. This results in a value that is easy to calculate and which is of importance since several studies have shown that it is correlated to the prevalence, incidence and progression of primary open angle glaucoma. Today, ocular perfusion pressure is used to estimate individual risks. Since no target value for ocular perfusion pressure can be defined, direct therapeutic intervention is difficult. Still, it has to be kept in mind that lowering intraocular pressure automatically leads to an increase in ocular perfusion pressure. The present article also points out problems and limitations in the concept of ocular perfusion pressure and suggests possible solutions for these problems in the future.

  15. Short Term Effect of Exercise on Intraocular Pressure of Ocular ...

    African Journals Online (AJOL)

    Short Term Effect of Exercise on Intraocular Pressure of Ocular Hypertensive Subjects. ... AFRICAN JOURNALS ONLINE (AJOL) · Journals · Advanced Search ... Keywords: Intraocular pressure; short term exercise; ocular hypertension.

  16. OCULAR INFECTIONS: RATIONAL APPROACH TO ANTIBIOTIC THERAPY

    Directory of Open Access Journals (Sweden)

    Mulla Summaiya A

    2012-02-01

    Full Text Available Background: Isolation of common pathogens involved in ocular infection and their in-vitro susceptibility to commonly used ocular antibiotics, as well as the trends in antibiotic resistance developed by these pathogens were investigated. Material/Methods: All patients with suspected bacterial ocular infections presenting between march 2010 and feb 2011 were examined under slit lamp microscope and samples were collected by using aseptic techniques. All samples were processed for direct microscopy, culture and identification by standard methods. Susceptibility testing was done by Kirby-Bauer method as per CLSI guideline. Results: Out of 116 patients with ocular infections 130 samples were collected, from which 38 different organisms were isolated. Gram-positive cocci 21 (55%, gram-negative cocco-bacilli 5(31% and gram-negative bacilli 12 (32% were isolated. Coagulase negative Staphylococci (37% and Pseudomonas species (21% were the most commonly-isolated. Gatifloxacin has highest efficacy (89% against all isolates. Majority of gram positive cocci were susceptible to vancomycin, gatifloxacin, cefazolin, gram negative cocco-bacilli to amikacin, tobramycin, fluoroquinolone and gram negative bacilli to gatifloxacin. Conclusion: Majority of ocular infection is caused by gram positive organisms which were susceptible to vancomycin followed by gram negative organisms susceptible to amikacin, fluoroquinolone, gram negative cocco-bacilli to amikacin and tobramycin, and gatifloxacin effective against both type of organisms. The information provided in this article help the clinician in formulating rationale-based empirical antibiotic treatment of bacterial ocular infections. [National J of Med Res 2012; 2(1.000: 22-24

  17. Alterações oculares em pacientes com tuberculose Ocular manifestation in patients with tuberculosis

    Directory of Open Access Journals (Sweden)

    Simone Ribeiro Araújo de Almeida

    2006-04-01

    Full Text Available OBJETIVO: Analisar os achados clínicos da tuberculose ocular e seus aspectos epidemiológicos. MÉTODOS: Foram revisados prontuários médicos de pacientes que foram atendidos no Departamento de Oftalmologia - setor de Uveíte e AIDS da Unifesp-EPM, São Paulo, Brasil, entre janeiro de 1999 e julho de 2002 e que tiveram diagnóstico de tuberculose ocular. Foram inclusos os pacientes que apresentaram PPD forte reator, epidemiologia positiva para tuberculose e lesão ocular que melhorou com tratamento específico. RESULTADOS: Foram analisados prontuários médicos de 17 pacientes, sendo 12 (70,6% do sexo feminino. A idade média foi de 54 (24-84 anos. O tempo médio entre o início dos sintomas e a primeira consulta foi de 100 dias. Os achados oculares foram inespecíficos nesta ocasião mas prevaleceram as alterações de segmento anterior e 41% dos pacientes apresentavam sinais de tuberculose sistêmica. Alterações como glaucoma, descolamento de retina e hemorragia vítrea foram responsáveis pela redução da acuidade visual. CONCLUSÃO: Embora pouco prevalente, a tuberculose ocular apresenta morbidade elevada. A inespecificidade da apresentação clínica da doença ocular pode atrasar o seu diagnóstico.PURPOSE: To analyze clinical findings of ocular tuberculosis and its epidemiological features. METHODS: Were reviewed clinical files of patients who attended the Ophthalmology - Uveitis and AIDS sector of UNIFESP-EPM, São Paulo, Brazil between January 1999 and July 2002 and had a diagnosis of ocular tuberculosis. Patients who had Mantoux test higher than 10 mm, epidemiological history of tuberculosis and ocular findings that improved after specific treatment were included. RESULTS: Seventeen medical files were analyzed, of those, 12 (70,6% were females. The mean age was 54 (24-84 years. The average time between symptoms and diagnosis was 100 days. Ocular findings at the first interview were multiple but most were at the anterior segment of

  18. Experimental Models of Ocular Infection with Toxoplasma Gondii

    OpenAIRE

    2015-01-01

    Ocular toxoplasmosis is a vision-threatening disease and the major cause of posterior uveitis worldwide. In spite of the continuing global burden of ocular toxoplasmosis, many critical aspects of disease including the therapeutic approach to ocular toxoplasmosis are still under debate. To assist in addressing many aspects of the disease, numerous experimental models of ocular toxoplasmosis have been established. In this article, we present an overview on in vitro, ex vivo, and in vivo models ...

  19. Ocular toxoplasmosis: an update and review of the literature

    Directory of Open Access Journals (Sweden)

    Alessandra G Commodaro

    2009-03-01

    Full Text Available Ocular toxoplasmosis is the most common cause of posterior uveitis worldwide. The infection can be acquired congenitally or postnatally and ocular lesions may present during or years after the acute infection occur. Current treatment controls ocular infection and inflammation, but does not prevent recurrences. We present a review and update on ocular toxoplasmosis and address misconceptions still found in the current medical literature.

  20. Current Imaging Modalities for assessing Ocular Blood Flow in Glaucoma

    OpenAIRE

    Mohindroo, Chirayu; Ichhpujani, Parul; Kumar, Suresh

    2016-01-01

    Glaucoma may be caused by an interplay of elevated intraocular pressure (IOP), vascular, genetic, anatomical, brain, and immune factors. The direct assessment of ocular hemodynam-ics offers promise for glaucoma detection, differentiation, and possibly new treatment modalities. All the methods currently in use to measure ocular blood flow have inherent limitations and measure different aspects of ocular blood flow. This review article attempts to provide detailed information on ocular perfu-si...

  1. Toxocariosis Ocular en Menores de Edad

    OpenAIRE

    Norma Ocampo; Liliam Cañas; Marta Hurtado; Jorge Botero; Mónica Lopera

    2001-01-01

    La toxocariosis es una geohelmintiosis producida por la ingestión de
    huevos de Toxocara canis y T. catis, cuyos hospederos definitivos son el perro y el gato. En el humano las larvas producen el Síndrome de Migración Larvaria Visceral y Ocular; en este último produce una enfermedad grave que puede semejar un retinoblastoma (1,2). Los niños son más susceptibles a adquirir esta infección (3). Nuestro objetivo es determinar la frecuencia de toxocariosis ocular en menores de edad con s...

  2. New Developments in Ocular Surface Squamous Neoplasia

    Directory of Open Access Journals (Sweden)

    Ayşe Yağcı

    2014-09-01

    Full Text Available Ocular surface squamous neoplasia originates from conjunctiva epithelium and covers a broad spectrum of disease ranging from dysplasia to squamous cell carcinoma. Clinical features may vary from case to case. Traditional treatment of excision with no-touch technique combined with adjuvant therapies because of high recurrence rate. Main adjuvant treatments are cryotherapy and chemotherapy. In this review, clinical forms, differential diagnosis, American Joint Committee on Cancer classification and recent approaches to the management of ocular surface squamous dysplasia were described. (Turk J Ophthalmol 2014; 44: Supplement 8-14

  3. Emerging ocular biomarkers of Alzheimer disease.

    Science.gov (United States)

    van Wijngaarden, Peter; Hadoux, Xavier; Alwan, Mostafa; Keel, Stuart; Dirani, Mohamed

    2017-01-01

    Interest in reliable biomarkers of Alzheimer disease, the leading cause of dementia, has been fuelled by challenges in diagnosing the disease and monitoring disease progression as well as the response to therapy. A range of ocular manifestations of Alzheimer disease, including retinal and lens amyloid-beta accumulation, retinal nerve fiber layer loss, and retinal vascular changes, have been proposed as potential biomarkers of the disease. Herein, we examine the evidence regarding the potential value of these ocular biomarkers of Alzheimer disease. © 2016 Royal Australian and New Zealand College of Ophthalmologists.

  4. PATOLOGIA OCULAR EM ANIMAIS DOMÉSTICOS

    OpenAIRE

    Tessie Beck Martins

    2015-01-01

    Esta tese envolveu o estudo de doenças oculares e perioculares de animais domésticos, e incluiu um artigo sobre lesões de patologia cirúrgica e um artigo sobre hifema em cães e gatos submetidos à necropsia. Para o primeiro trabalho, foram examinados 33.075 laudos de exames histopatológicos realizados num laboratório de diagnóstico de patologia veterinária na Região Central do Rio Grande do Sul durante 50 anos. Destes, 540 (1,6%) eram de lesões oculares e perioculares. Por vária...

  5. Psychological aspects in ocular prosthesis users

    OpenAIRE

    2003-01-01

    OBJETIVO: Avaliar os aspectos psicológicos decorrentes da anoftalmia unilateral adquirida, a luta pela recuperação estética com o uso de prótese ocular, assim como os fatores interpessoais envolvidos e a reintegração psicossocial destes pacientes. MÉTODO: Trinta pacientes portadores de anoftalmia unilateral adquirida, sem outras deformidades órbito-palpebrais e usuários de prótese ocular, sendo 16 do sexo masculino e 14 feminino, com idade variando de 12 a 66 anos, idade média 31,6 anos foram...

  6. Genetics in ocular inflammation--basic principles.

    Science.gov (United States)

    Wallace, G R; Niemczyk, E

    2011-02-01

    The ability to identify individuals at risk of ocular disease, or to determine the potential severity of disease or response to therapy is the current focus of much research. These studies are being led by genetic analysis of individuals to determine associations with alterations in gens that may explain manifestations of particular diseases. In this review we consider the basic principles behind genetic studies in general and of ocular disease in particular. We address the methodologies being utilised, and the results derived so far. The potential and pitfalls of such studies are relevant to the concept of personalised medicine and better defined clinical trials.

  7. Sarcoidosis: Oral and extra-oral manifestation

    Directory of Open Access Journals (Sweden)

    Sanjay Gupta

    2015-01-01

    Full Text Available Sarcoidosis is a multisystem granulomatous disease, which is usually associated with the formation of noncaseating granulomas in affected tissues and organs. It is mostly present with bilateral hilar lymphadenopathy, pulmonary infiltration, ocular, and cutaneous lesions. Oral manifestations of this disease are relatively rare. The present case report shows a 40-year-old male with lesions in the soft tissue of oral cavity (buccal mucosa, gingiva, and palate and a diagnosis of sarcoidosis was established following hematological, biochemical and pulmonary function tests, chest radiograph, and histopathological investigation.

  8. Do agility and skull architecture influence the geometry of the mammalian vestibulo-ocular reflex?

    Science.gov (United States)

    Jeffery, Nathan; Cox, Philip G

    2010-04-01

    The spatial arrangement of the semicircular canals and extraocular muscles of the eye has been of considerable interest, particularly to researchers working on adaptations of the vestibulo-ocular reflex. Here we offer the first, extensive comparative analysis of the spatial relationships between each extraocular muscle and the canal providing its primary excitatory stimulus. The sample consisted of 113 specimens, representing 51 extant mammalian species. Hypotheses tested included that variations in the spatial alignments are linked with differences of skull morphology and with differences of agility during locomotion. Internal morphologies were visualized with magnetic resonance imaging and were measured with landmark-based vectors and planes. Values for body mass and agility were taken from the existing literature. Data were investigated for trends and associations with standard bivariate and multivariate statistical methods as well as with phylogenetically adjusted bivariate methods. The findings clearly show that species differences in the alignment of each extraocular muscle relative to the canal providing its primary excitatory stimulus are closely associated with changes of orbit morphology. The results also indicate that the actions of the oblique muscles interchange with those of the superior and inferior recti muscles when comparing lateral-eyed (rabbit) with frontal-eyed species (cat). There was only weak evidence to support the notion that canal-muscle alignments differ significantly among species according to how agile they are. The results suggest that semicircular canal morphology is arranged primarily for detecting head movements and then secondarily, if at all, for diminishing the burden of transforming vestibulo-ocular reflex signals in the most agile species.

  9. Comments on frontonasal dysplasia, ocular hypertelorism and dystopia canthorum.

    Science.gov (United States)

    Peterson, M Q; Cohen, M M; Sedano, H O; Frerichs, C T

    1971-06-01

    The mean canthal index values of patients with frontonasal dysplasia are tested for differences in facies A, B, C, and D. A general discussion of ocular hypertelorism and dystopia canthorum is presented. Ocular hypertelorism is considered a sign which may occur in a variety of disorders. Quantitative methods for determining ocular hypertelorism are critically reviewed.

  10. 21 CFR 886.4360 - Ocular surgery irrigation device.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Ocular surgery irrigation device. 886.4360 Section... (CONTINUED) MEDICAL DEVICES OPHTHALMIC DEVICES Surgical Devices § 886.4360 Ocular surgery irrigation device. (a) Identification. An ocular surgery irrigation device is a device intended to be suspended over...

  11. Ocular vestibular evoked myogenic potentials in normal-hearing adults

    Directory of Open Access Journals (Sweden)

    Mohammad Kamali

    2012-06-01

    Full Text Available Background and Aim: Ocular vestibular-evoked myogenic potential (oVEMP is a novel vestibular function test. This short-latency response can be recorded through contracting extraocular muscles by high-intensity acoustic stimulation and can be used to evaluate contralateral ocular-vestibular reflex. The aim of this study was to record and compare the amplitude, latency, asymmetry ratio and occurrence percentage of oVEMP (n10 and cervical VEMP (p13 responses in a group of normal adult subjects.Methods: We carried out a cross-sectional study on 20 adult subjects' mean age 22.18 years, SD=2.19 with normal hearing sensitivity and no history of vestibular diseases. oVEMP and cVEMP responses in both ears were recorded using air conducted stimuli 500 Hz short tone burst, 95 dB nHL via insert earphone and compared.Results: cVEMP was recorded in all subjects but oVEMP was absent in two subjects. Mean amplitude and latency were 140.77 μv and 15.56 ms in p13; and 3.18 μv and 9.32 ms in n10. There were statistically significant differences between p13 and n10 amplitudes (p<0.001.Conclusion: This study showed that occurrence percentage and amplitude of oVEMP were less than those of cVEMP. Since these two tests originate from different sections of vestibular nerve, we can consider them as parallel vestibular function tests and utilize them for evaluation of vestibular disorders.

  12. Construction Process Control of Large Extra Caissons

    Institute of Scientific and Technical Information of China (English)

    HU Shaowei; WANG Hongxia; FAN Jiansheng

    2005-01-01

    The complexity of geotechnical engineering and variability in construction circumstances of large extra caissons make the problem of maintaining appropriate sink attitude quite difficult, especially in keeping sink uniformity and achieving the expected final sink depth. A new construction control method is presented using (H∞) theory, considering uncertainties in the mechanics model and external noise in the construction site parameters. The design method of an (H∞) controller has consequently been obtained for large extra caissons. Control results using only constructor experiences are compared with simulation results using the (H∞) controller for a practical engineering situation, which indicates that the (H∞) controller is successful in maintaining sink uniformity, avoiding sink as well as in achieving the expected final sink depth.

  13. Brane modeling in warped extra-dimension

    CERN Document Server

    Ahmed, Aqeel

    2012-01-01

    Five-dimensional scenarios with infinitesimally thin branes replaced by appropriate configurations of a scalar field were considered. A possibility of periodic extra dimension was discussed in the presence on non-minimal scalar-gravity coupling and a generalized Gibbons-Kallosh-Linde sum rule was found. In order to avoid constraints imposed by periodicity, a non-compact spacial extra dimension was introduced. A five dimensional model with warped geometry and two thin branes mimicked by a scalar profile was constructed and discussed. In the thin brane limit the model corresponds to a set-up with two positive-tension branes. The presence of two branes allows to address the issue of the hierarchy problem which could be solved by the standard warping of the four dimensional metric. Stability of the background solution was discussed and verified in the presence of the most general perturbations of the metric and the scalar field.

  14. Indirect Collider Signals for Extra Dimensions

    CERN Document Server

    Hewett, J L

    1999-01-01

    A recent suggestion that quantum gravity may become strong near the weak scale has several testable consequences. In addition to probing for the new large (submillimeter) extra dimensions associated with these theories via gravitational experiments, one could search for the Kaluza Klein towers of massive gravitons which are predicted in these models and which can interact with the fields of the Standard Model. Here we examine the indirect effects of these massive gravitons being exchanged in fermion pair production in \\epem\\ annihilation and Drell-Yan production at hadron colliders. In the latter case, we examine a novel feature of this theory, which is the contribution of gluon gluon initiated processes to lepton pair production. We find that these processes provide strong bounds, up to several TeV, on the string scale which are essentially independent of the number of extra dimensions. In addition, we analyze the angular distributions for fermion pair production with spin-2 graviton exchanges and demonstrat...

  15. Extra-dimensional confinement of quantum particles

    CERN Document Server

    Hedin, Eric R

    2016-01-01

    A basic theoretical framework is developed in which elementary particles have a component of their wave function extending into higher spatial dimensions. This model postulates an extension of the Schrodinger equation to include a 4th and 5th spatial component. A higher-dimensional simple harmonic oscillator confining potential localizes particles into 3-d space, characterizing the brane tension which confines Standard Model particles to the sub-manifold. Quantum effects allow a non-zero probability for a particle's evanescent existence in the higher dimensions, and suggest an experimental test for the validity of this model via particles being temporarily excited into the first excited state of the extra-dimensional potential well, in which their probability of existing in 3-d space transiently drops to zero. Several consistency checks of the outcomes of this extra-dimensional model are included in this paper. Among the outcomes of this model are: a match with the quantum phenomenon of zitterbewegung; the pr...

  16. Celulitis por cuerpo extraño

    Directory of Open Access Journals (Sweden)

    Miguel B. Carrasco Guzmán

    2016-01-01

    Full Text Available Las infecciones de la piel y el tejido celular subcutáneo surgen como un grupo importante de afecciones con una alta morbilidad en edades pediátricas, generalmente relacionada con traumatismo y cuerpos extraños. Se presenta el caso de una escolar femenina de 6 años de edad, con síntomas y signos clínicos que sugieren celulitis en el muslo derecho,  por su evolución tórpida se le realizó el estudio ultrasonográfico que confirmó el diagnóstico etiológico de una celulitis secundaria a un traumatismo, provocada por la introducción de un gran cuerpo extraño, que pasó inadvertido para a familia de la menor.

  17. Neutrino anomalies and large extra dimensions

    CERN Document Server

    Dighe, A S; Dighe, Amol S.; Joshipura, Anjan S.

    2001-01-01

    Theories with large extra dimensions can generate small neutrino masses when the standard model neutrinos are coupled to singlet fermions propagating in higher dimensions. The couplings can also generate mass splittings and mixings among the flavour neutrinos in the brane. We systematically study the minimal scenario involving only one singlet bulk fermion coupling weakly to the flavour neutrinos. We explore the neutrino mass structures in the brane that can potentially account for the atmospheric, solar and LSND anomalies simultaneously in a natural way. We demonstrate that in the absence of a priori mixings among the SM neutrinos, it is not possible to reconcile all these anomalies. The presence of some structure in the mass matrix of the SM neutrinos can solve this problem. This is exemplified by the Zee model, which when embedded in extra dimensions in a minimal way can account for all the neutrino anomalies.

  18. Origin of extra chromosome in Patau syndrome.

    Science.gov (United States)

    Ishikiriyama, S; Niikawa, N

    1984-01-01

    Five live-born infants with Patau syndrome were studied for the nondisjunctional origin of the extra chromosome. Transmission modes of chromosomes 13 from parents to a child were determined using both QFQ- and RFA-heteromorphisms as markers, and the origin was ascertained in all of the patients. The extra chromosome had originated in nondisjunction at the maternal first meiotic division in two patients, at the maternal second meiosis in other two, and at the paternal first meiosis in the remaining one. Summarizing the results of the present study, together with those of the previous studies on a liveborn and abortuses with trisomy 13, nondisjunction at the maternal and the paternal meiosis occurred in this trisomy in the ratio of 14:3. This ratio is not statistically different from that inferred from the previous studies for Down syndrome. These findings suggest that there may be a fundamental mechanism common to the occurrence of nondisjunction in the acrocentric trisomies.

  19. Níveis de triglicerídeos intra e extracelulares em músculos humanos mediante ¹H-ERM: um estudo de caso Niveles de triglicéridos intra y extracelulares en músculos humanos mediante 1H-ERM: estudio de caso Levels of intra and extra cellular triglycerides in human muscles by means of ¹H-ERM: a case study

    Directory of Open Access Journals (Sweden)

    Maria Gisele dos Santos

    2004-10-01

    Full Text Available O objetivo deste estudo foi analisar o consumo de triglicerídeos intra (IT e extracelulares (ET nos músculos sóleo, tibial anterior e vasto medial após uma prova de quatro horas de ciclismo de estrada. Esta pesquisa caracterizou-se por ser um estudo de caso de um ciclista que participa de competições internacionais. Os estudos de ressonância magnética utilizaram os seguintes parâmetros espectrais impostos para o ajuste no domínio do tempo, como a distância das freqüências entre os sinais de IT e ET. Os valores de amplitudes dos triglicerídeos intra e extracelulares foram divididos pela ressonância de água. Concluímos que o músculo vasto medial do ciclista apresentou maior consumo de triglicerídeos depois de quatro horas de ciclismo em estrada. Portanto, constatou-se que um trabalho com intensidade de 80% da freqüência cardíaca máxima permitiu consumo de triglicerídeos intramusculares durante o exercício.El objetivo de este estudio fue el de analizar el consumo de triglicéridos intra (IT y extracelulares (ET en los músculos soleo, tibial anterior y vasto medial tras una prueba de cuatro horas de ciclismo de ruta. Esta investigación es un estudio de caso de un ciclista que participa de competiciones internacionales. Los estudios de resonancia magnética utilizaron los siguientes parámetros espectrales que se impusieron para el ajuste en el dominio del tiempo, como la distancia de las frecuencias entre las señales de IT e ET. Los valores de amplitudes de los triglicéridos intra y extracelulares fueron divididos por resonancia de agua. Concluimos que el músculo vasto medial del ciclista presentó mayor consumo de triglicéridos luego de cuatro horas de ciclismo en ruta. Por lo tanto, se verificó que un trabajo con intensidad del 80% de la frecuencia cardiaca máxima permitió el consumo de triglicéridos intramusculares durante el ejercicio.The objective of this study was to analyze the intra (IT and extra cellular

  20. Precision Constraints on Extra Fermion Generations

    CERN Document Server

    Erler, Jens

    2010-01-01

    In the recent past there has been renewed interest in the possibility of additional fermion generations. At the same time there have been significant changes in the relevant electroweak (EW) precision constraints, in particular in the interpretation of several of the low energy experiments. We summarize the various motivations for the increased activity regarding extra families and analyze them in view of the latest EW precision data.

  1. Extra gauge symmetries in BHT gravity

    CERN Document Server

    Blagojević, M

    2011-01-01

    We study the canonical structure of the Bergshoeff-Hohm-Townsend massive gravity, linearized around a maximally symmetric background. At the critical point in the space of parameters, defined by $\\Lambda_0/m^2=-1$, we discover an extra gauge symmetry, which reflects the existence of the partially massless mode. The number of the Lagrangian degrees of freedom is found to be 1. We show that the canonical structure of the theory at the critical point is unstable under linearization.

  2. Extra gauge symmetries in BHT gravity

    Science.gov (United States)

    Blagojević, M.; Cvetković, B.

    2011-03-01

    We study the canonical structure of the Bergshoeff-Hohm-Townsend massive gravity, linearized around a maximally symmetric background. At the critical point in the space of parameters, defined by Λ 0/ m 2 = -1, we discover an extra gauge symmetry, which reflects the existence of the partially massless mode. The number of the Lagrangian degrees of freedom is found to be 1. We show that the canonical structure of the theory at the critical point is unstable under linearization.

  3. Quantum simulation of an extra dimension.

    Science.gov (United States)

    Boada, O; Celi, A; Latorre, J I; Lewenstein, M

    2012-03-30

    We present a general strategy to simulate a D+1-dimensional quantum system using a D-dimensional one. We analyze in detail a feasible implementation of our scheme using optical lattice technology. The simplest nontrivial realization of a fourth dimension corresponds to the creation of a bi-volume geometry. We also propose single- and many-particle experimental signatures to detect the effects of the extra dimension.

  4. Dimensional reduction without continuous extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Chamseddine, Ali H. [American University of Beirut, Physics Department, Beirut, Lebanon and I.H.E.S. F-91440 Bures-sur-Yvette (France); Froehlich, J.; Schubnel, B. [ETHZ, Mathematics and Physics Departments, Zuerich (Switzerland); Wyler, D. [Institute of Theoretical Physics, University of Zuerich (Switzerland)

    2013-01-15

    We describe a novel approach to dimensional reduction in classical field theory. Inspired by ideas from noncommutative geometry, we introduce extended algebras of differential forms over space-time, generalized exterior derivatives, and generalized connections associated with the 'geometry' of space-times with discrete extra dimensions. We apply our formalism to theories of gauge- and gravitational fields and find natural geometrical origins for an axion- and a dilaton field, as well as a Higgs field.

  5. Systematic analysis of ocular trauma by a new proposed ocular trauma classification

    Directory of Open Access Journals (Sweden)

    Bhartendu Shukla

    2017-01-01

    Full Text Available Purpose: The current classification of ocular trauma does not incorporate adnexal trauma, injuries that are attributable to a nonmechanical cause and destructive globe injuries. This study proposes a new classification system of ocular trauma which is broader-based to allow for the classification of a wider range of ocular injuries not covered by the current classification. Methods: A clinic-based cross-sectional study to validate the proposed classification. We analyzed 535 cases of ocular injury from January 1, 2012 to February 28, 2012 over a 4-year period in an eye hospital in central India using our proposed classification system and compared it with conventional classification. Results: The new classification system allowed for classification of all 535 cases of ocular injury. The conventional classification was only able to classify 364 of the 535 trauma cases. Injuries involving the adnexa, nonmechanical injuries and destructive globe injuries could not be classified by the conventional classification, thus missing about 33% of cases. Conclusions: Our classification system shows an improvement over existing ocular trauma classification as it allows for the classification of all type of ocular injuries and will allow for better and specific prognostication. This system has the potential to aid communication between physicians and result in better patient care. It can also provide a more authentic, wide spectrum of ocular injuries in correlation with etiology. By including adnexal injuries and nonmechanical injuries, we have been able to classify all 535 cases of trauma. Otherwise, about 30% of cases would have been excluded from the study.

  6. Ocular Immune Privilege in the Year 2010: Ocular Immune Privilege and Uveitis

    OpenAIRE

    Taylor, Andrew W.; Kaplan, Henry J.

    2010-01-01

    The phrase “immune privilege” was coined by Peter Medawar to describe the absence of an immune response to allografts placed into the anterior chamber of the eye or brain. We now understand that immune privilege is more than a passive microenvironment with a distinctive anatomical structure that holds back immunity. The ocular microenvironment actively engages the immune system with immunosuppressive biochemical mechanisms. The unique characteristics of ocular immune privilege appear designed...

  7. DNA nanoparticles as ocular drug delivery platform

    NARCIS (Netherlands)

    de Vries, Jan Willem

    2015-01-01

    The field of DNA nanotechnology has progressed rapidly in recent years and now offers facile fabrication of a large variety of nanostructures of different shapes and geometries. In this thesis, short nucleic acid sequences are functionalized with hydrophobic units to form the basis of an ocular drug

  8. Pattern of Ocular Injuries in Owo, Nigeria

    Directory of Open Access Journals (Sweden)

    Charles Oluwole Omolase

    2011-01-01

    Full Text Available Purpose: To determine the pattern of ocular injuries in patients presenting to the eye clinic and the accident and emergency department of Federal Medical Center, Owo, Ondo State, Nigeria. Methods: This prospective study was conducted between January and December 2009. Federal Medical Center, Owo is the only tertiary hospital in Ondo State, Nigeria. The eye center located at this medical center was the only eye care facility in the community at the time of this study. All patients were interviewed with the aid of an interviewer-administered questionnaire and underwent a detailed ocular examination. Results: Of 132 patients included in the study, most (84.1% sustained blunt eye injury while (12.1% had penetrating eye injury. A considerable proportion of patients (37.9% presented within 24 hours of injury. Vegetative materials were the most common (42.4% offending agent, a minority of patients (22% was admitted and none of the patients had used eye protection at the time of injury. Conclusion: In the current series, blunt eye injury was the most common type of ocular trauma. The community should be educated and informed about the importance of preventive measures including protective eye devices during high risk activities. Patients should be encouraged to present early following ocular injury.

  9. Ocular malignant lymphoma. A clinical pathological study

    Directory of Open Access Journals (Sweden)

    Panda A

    1987-01-01

    Full Text Available Eleven histologically proved cases of ocular malignant lymphoma diagnosed and managed during the year 1974-81 are reported. The follow-up period ranges from 2-7 years. The difficulties in diagnosis, treatment and prognosis are discussed.

  10. Ocular myasthenia gravis coincident with thyroid ophthalmopathy

    Directory of Open Access Journals (Sweden)

    Yaman A

    2003-01-01

    Full Text Available Graves' disease and myasthenia gravis are both auto-immune diseases and the coexistence of these two diseases is well recognized. Myasthenia gravis is more frequent in patients with thyroid disease. Here we present a case of thyroid ophthalmopathy and ocular myasthenia.

  11. Candidate genes in ocular dominance plasticity

    NARCIS (Netherlands)

    M.L. Rietman; J.-P. Sommeijer; C.N. Levelt; J.A. Heimel; A.B. Brussaard; J.G.G. Borst; Y. Elgersma; N. Galjart; G.T. van der Horst; C.M. Pennartz; A.B. Smit; B.M. Spruijt; M. Verhage; C.I. de Zeeuw

    2012-01-01

    Many studies have been devoted to the identification of genes involved in experience-dependent plasticity in the visual cortex. To discover new candidate genes, we have reexamined data from one such study on ocular dominance (OD) plasticity in recombinant inbred BXD mouse strains. We have correlated

  12. Ocular rosacea: common and commonly missed.

    Science.gov (United States)

    Vieira, Ana Carolina; Mannis, Mark J

    2013-12-01

    Rosacea is a prevalent disorder that may be disfiguring and cause significant ocular morbidity, if not diagnosed and managed appropriately. Ocular rosacea, in particular, is often left undiagnosed as no specific test is available to confirm the diagnosis. Accurate diagnosis is further complicated because symptoms of ocular rosacea are not always specific to the disorder alone. Other ophthalmic disorders may present with similar findings. Further challenges exist because the severity of ocular symptoms is often not related to the severity of cutaneous findings in rosacea. Isolating a disease marker may facilitate earlier diagnosis and treatment, and could also contribute to better understanding of disease pathogenesis. The glycomics of tear fluid and saliva in patients with rosacea shows promise as an initial step in the search for a biomarker specific to the disease. We have previously found potentially important disease biomarkers in roseatic tear and saliva samples. Further investigation should prove important in the early stages of developing a set of markers for accurate disease identification.

  13. Ocular surface squamous neoplasia in Ibadan, Nigeria

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    Oluyemi Fasina

    2015-01-01

    Conclusion: OSSN occurs in younger individuals, and is strongly associated with HIV infection in our environment. Early diagnosis and intervention can prevent severe ocular morbidity. Wide surgical excision with intra-operative cryotherapy and adjuvant treatment with topical MMC post-operatively seem to give good outcome in our patients.

  14. Ocular findings in the chronic renal failure

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    P Dahal

    2015-07-01

    Full Text Available BACKGROUND The aim of the study was to evaluate the ocular signs in chronic renal failure (CRF in diabetes and hypertensive patients. MATERIALS AND METHODS Two hundred and thirty eight cases were enrolled in the study from the nephrology unit of College Of Medical Science, Bharatpur, Nepal and examined in the department of Ophthalmology. The study duration was carried out over 2 years from January 2011 to December 2012. RESULT The number of cases in each grade of CRF were mild 80 (26.67%, moderate 84 (28%, severe 75 (25%, end stage renal disease 61 (20.33%. In all the groups the commonest cause of CRF were Hypertension (HTN 123 out of 300(41% and diabetes 98(32.67%. The commonest ocular symptoms in CRF was blurring of vision 68%. CONCLUSION Many important ocular findings like vitreous haemorrage, retinal detachment, neovascular glaucoma and cataract are the presentation in chronic renal failure, which can cause marked vision loss. Hence proper awareness should be provided to the people in time to prevent these ocular complications.DOI: http://dx.doi.org/10.3126/jcmsn.v10i2.12949 Journal of College of Medical Sciences-Nepal, 2014, Vol.10(2; 18-26

  15. Collider Implications Of Extra Dimensions At Lhc

    CERN Document Server

    Reema

    2005-01-01

    Scope and method of study. The intent of this research is to consider multiple TeV-1-size extra compact dimensions in an asymmetric string compactification scenario in which the SM gauge bosons can propagate into the TeV-1-size extra dimensions while the SM fermions are confined to the usual SM D3-brane. The contributions that the KK excitations of the gluons, g*'s, make to the multijet cross sections in proton- proton collisions at the LHC energy are calculated. Fortran was used to do the calculations. Findings and conclusions. At very high pT, the dijet signal will either be enhanced significantly due to virtual g* exchanges or place a lower bound on the compactification scale of about 8 TeV. It is found that the dijet signal is very sensitive to three parameters—the compactification scale, the string scale, and the number of extra dimensions. Thus, although the dijet signal is much more sensitive to KK effects, the dijet signal alone does not provide sufficient information to deduce the number of...

  16. MR findings of extra abdominal fibromatosis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Hee Jin; Lee, Sung Moon; Rhee, Chang Soo; Sohn, Chul Ho; Lee, Hee Jung; Kim, Jung Sik; Kim, Hong [Dongsan Medical Center, Keimyung Univ. College of Medicine, Taegu (Korea, Republic of); Seo, Kyung Jin [Suh Joo MRI center, Seoul (Korea, Republic of); Jo, Kil Ho [Youngnam Univ. College of Medicine, Kyongsan (Korea, Republic of)

    1999-12-01

    To evaluate the MR findings of extra-abdominal fibromatosis and the role of MRI in primary diagnosis Fifteen cases in of histologically proven extra-abdominal fibromatosis in 13 patients were retrospectively reviewed. T1-weighted and T2-weighted images were obtained in axial, coronal and sagittal planes. Gd-enhancement was performed in 14 cases, and dynamic enhancement studies in two. All lesions were evaluated for mass shape and margin definition. Among the 15 cases, tumors of the buttock accounted for five, and tumor of the thigh for two. in eight cases tumors were intermuscular and in six cases were intramuscular. In ten cases (67%) the mass extended along the long axis of the body and in 14 of 15 cases (93%) focal infiltration of adjacent structures was visible. The signal intensity of the lesion was in all cases inhomogeneous on both T1 and T2 weighted images. As seen on Gd-DTPA enhanced scans, the masses were inhomogeneously enhanced. In all cases MRI revealed star-shaped linear strands or a band-like low signal area in the mass. These features were not enhanced and were arranged along the long axis of the mass. MR findings of extra-abdominal fibromatosis were relatively characteristic and helpful for primary diagnosis of the condition.

  17. Muscle biopsy

    Science.gov (United States)

    ... Inflammatory diseases of muscle (such as polymyositis or dermatomyositis ) Diseases of the connective tissue and blood vessels ( ... disease that involves inflammation and a skin rash ( dermatomyositis ) Inherited muscle disorder ( Duchenne muscular dystrophy ) Inflammation of ...

  18. Muscle atrophy

    Science.gov (United States)

    ... atrophy. Exercises may include ones done in a swimming pool to reduce the muscle workload, and other types ... a physical examination and ask about your medical history and symptoms, including: When did the muscle atrophy ...

  19. Diffuse corneal abrasion after ocular exposure to laundry detergent pod.

    Science.gov (United States)

    Whitney, Rachel E; Baum, Carl R; Aronson, Paul L

    2015-02-01

    Although ocular injury from alkaline household cleaning products is well described, there is less known about the significance and extent of injury with ocular exposure to detergent pods. We report a 12-month-old with diffuse corneal abrasion caused by ocular contact with a laundry detergent pod. In addition to the known risks with aspiration with detergent pods, the potential for severe ocular injury is important for parents and clinicians to recognize. Children with ocular exposure to detergent pods should seek immediate medical care.

  20. Doenças oculares em neonatos

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    Endriss Daniela

    2002-01-01

    Full Text Available Objetivo: Identificar as principais doenças oculares numa população de neonatos assistidos pelo Sistema Único de Saúde em maternidades de referência no Estado de Pernambuco, orientando o seguimento e tratamento necessário. Métodos: Realizou-se estudo de corte transversal numa população de recém-nascidos em três maternidades públicas, no período de abril a outubro de 2000. Procedeu-se ao exame oftalmológico durante visitas semanais, orientando-se o seguimento e tratamento dos casos com alterações oculares ou fatores de risco. Resultados: Examinaram-se 3280 recém-nascidos: 1403 (42,8% na Maternidade da Encruzilhada (CISAM, 1232 (37,5% na Maternidade do Hospital Barão de Lucena (MHBL e 645 (19,7% na Maternidade do Hospital Agamenon Magalhães (MHAM. 387 eram pré-termo (11,8% dos casos. Encaminharam-se ao serviço especializado 701 neonatos (21,4% do total examinado com alterações oculares ou com fatores de risco. Destes, 46,4% eram pré-têrmo e 37,9% receberam oxigenoterapia, observando-se maior número porcentual na MHBL (45,4%. Observou-se conjuntivite em 3,0% dos olhos, leucocoria em 0,4% e hemorragia subconjuntival em 2,0%. À fundoscopia, encontraram-se hemorragias retinianas em 7,8% dos casos, com acometimento macular em 4,3%. Conclusões: As doenças oculares mais freqüentes foram: hemorragias retinianas e conjuntivites. Os principais fatores de risco observados foram: prematuridade e doenças infecciosas neonatais. Os autores enfatizam que o exame ocular deve ser realizado rotineiramente nos neonatos.

  1. OCULAR HYPERTENSION - RISK FACTORS AND THERAPY?

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    Janićijević Katarina

    2015-12-01

    Full Text Available Introduction/Aim: The goal of our study was to analyze the epidemiological`s characteristics of ocular hypertension, as well as the influence of chronic risk factors on glaucoma development (conversion in glaucoma. We tried to make some entries for solving this complex ophthalmological problem. Material /Methods: From 2009 to 2015, a retrospective control study was performed on 121 patient with diagnoses of bilateral ocular hypertension and without disease progression/conversion of glaucoma (by standard protocols of diagnosis and basic procedures on tertiary level at Clinic of Ophthalmology, Clinical Centre of Kragujevac, Serbia.. The authors analyzed epidemiological characteristics: sex, age groups, positive/negative family history and personal history with chronic risk factors (one and/or two of ocular hypertension. The data obtained from this study were statistically analyzed in SPSS program, version 20.00. Results: As for the patients, 69 of them (57.02% were male and 52 female (42.98%. Dominant age group was between 40-49 (42.15% and then group between 50-59 (40.50% years of age. Anamnesis data indicated the absence of family anamnesis 71 (58.68%. Risk factors for ocular hypertension were presented in 103 (85.13% patients, 18 of them (14.87% did not respond. One risk factor - cardiovascular disease was noted in 83 (68.59%, with two risk factors - cardiovascular diseases and diabetes mellitus in 20 patients (16.53% and with PEX syndroma at other respondents. Conclusion: Ocular hypertension is not a common disease, but with risk factors, such as older age, positive family history, and chronic risk factors syndicated, represents a serious clinical and social problem, so the question remains for ophthalmologists - pro or against therapy? Those in favor of therapy would state the safety and protection from conversion/progression of glaucoma; but those  against therapy would only mention adequate monitoring of patients.

  2. Epidemiological aspects of ocular superglue injuries

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    Seyed Ali Tabatabaei

    2016-02-01

    Full Text Available AIM: To report the frequency, associated risk factors and characteristics of cases referred to Farabi Eye Hospital with ocular superglue injuries. METHODS: In a descriptive cross-sectional study conducted between December 2012 and February 2013, patients with ocular superglue injuries were evaluated. Age, sex, educational level, location, time, mechanism, type, site and time of eye injury were gathered through interview using a customized questionnaire. All participants had given consent to undergo thorough eye examination. RESULTS: Over the course of three months, 105 patients with ocular superglue injuries enrolled in the study, including 56(53.3% men and 49(46.7% women with the mean age of 24.7±11.6 (range, 2 to 53y. The right eye, left eye and both eyes were involved in 52%, 42% and 6% of the patients, respectively. Most of injuries had occurred at home (72.4% and at night (55%. More than half of patients (52.4% did not take any primary aids following the ocular injury. Patient carelessness (78.1%, childhood curiosity and lack of parental supervision (11.4%, storing superglue in inappropriate places and inadvertently using superglue as eye drops due to poor vision (2.9%, inadequate awareness of superglue applications [used to stick on artificial nails (3.8%, artificial eyelashes (1.9% and broken tooth (1%] and being assaulted with glue (1% were common risk factors. CONCLUSION: The frequency of ocular superglue injuries in patients referred to Farabi Eye Hospital is relatively high. This finding underlines the importance of public education and awareness about superglue injuries to the eye and taking protective measures and safety strategies in order to prevent these injures.

  3. Congenital Ocular Dystopia from Orbitofrontal Bone Dysplasia.

    Science.gov (United States)

    Swanson, Jordan W; Bartlett, Scott P

    2016-01-01

    Several patients with ocular dystopia and craniofacial differences have been found to have orbital dysplasia and a frontal bone defect. This deformity is characteristically different from differential diagnoses of encephalocele, sphenoid dysplasia, craniofacial dysostoses, or atypical clefting. The authors retrospectively reviewed the craniofacial registries of two pediatric centers for patients presenting with ocular dystopia or orbitofrontal anomalies between 2000 and 2014. The features and treatment of these patients were analyzed. Four patients with congenital orbitofrontal bone dysplasia were identified, three with unilateral and one with bilateral frontal bone defects. Clinical signs of hypoglobus and vertical ocular dystopia of an average of 5.0 mm on the affected side were noted shortly after birth. The transversely oriented bony defect had an average surface area of 3.9 cm in unilateral cases and 10.7 cm in bilateral cases. Patients showed a characteristic orbital vertical elongation with an average orbital height-to-width ratio of 1.30-in excess of the average normal 1.14 by 14 percent-and inferior rim displacement. Cranial contour demonstrated frontal bossing and borderline dolichocephaly. Fronto-orbital reconstruction was performed in three patients, using cranial bone grafting to obliterate the orbital roof defect and elevate the orbital floor, which was successful in reducing ocular dystopia and preserving vision in each patient. One patient followed for 11 years postoperatively has a durable result with no surgical revision. Orbitofrontal bone dysplasia has not been previously reported, and includes a frontal bone defect and ocular dystopia. Single-stage fronto-orbital reconstruction appears to adequately correct it. Therapeutic, IV.

  4. Ocular toxicity of authentic lunar dust

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    Meyers Valerie E

    2012-07-01

    Full Text Available Abstract Background Dust exposure is a well-known occupational hazard for terrestrial workers and astronauts alike and will continue to be a concern as humankind pursues exploration and habitation of objects beyond Earth. Humankind’s limited exploration experience with the Apollo Program indicates that exposure to dust will be unavoidable. Therefore, NASA must assess potential toxicity and recommend appropriate mitigation measures to ensure that explorers are adequately protected. Visual acuity is critical during exploration activities and operations aboard spacecraft. Therefore, the present research was performed to ascertain the ocular toxicity of authentic lunar dust. Methods Small (mean particle diameter = 2.9 ± 1.0 μm, reactive lunar dust particles were produced by grinding bulk dust under ultrapure nitrogen conditions. Chemical reactivity and cytotoxicity testing were performed using the commercially available EpiOcularTM assay. Subsequent in vivo Draize testing utilized a larger size fraction of unground lunar dust that is more relevant to ocular exposures (particles Results In vitro testing indicated minimal irritancy potential based on the time required to reduce cell viability by 50% (ET50. Follow-up testing using the Draize standard protocol confirmed that the lunar dust was minimally irritating. Minor irritation of the upper eyelids was noted at the 1-hour observation point, but these effects resolved within 24 hours. In addition, no corneal scratching was observed using fluorescein stain. Conclusions Low-titanium mare lunar dust is minimally irritating to the eyes and is considered a nuisance dust for ocular exposure. No special precautions are recommended to protect against ocular exposures, but fully shielded goggles may be used if dust becomes a nuisance.

  5. Your Muscles

    Science.gov (United States)

    ... develops. There they help to push the baby out of the mother's body when it's time to be born. You'll find smooth muscles at work behind the scenes in your eyes, too. These muscles keep the eyes ... thick muscles of the heart contract to pump blood out and then relax to let blood back in ...

  6. Modeling Muscles

    Science.gov (United States)

    Goodwyn, Lauren; Salm, Sarah

    2007-01-01

    Teaching the anatomy of the muscle system to high school students can be challenging. Students often learn about muscle anatomy by memorizing information from textbooks or by observing plastic, inflexible models. Although these mediums help students learn about muscle placement, the mediums do not facilitate understanding regarding integration of…

  7. Estudo sobre a aplicabilidade de adesivos biológicos à reinserção de músculo ocular externo em coelhos - II. Experimento II - Medida das distâncias das bordas nasal e temporal do músculo ao limbo e da extensão da adesão tecidual A study of the applicability of biological adhesives to the insertion of an external ocular muscle in rabbits - II. Experiment II - Measurement of the distances from the nasal and temporal muscles to the limbus and of the extent of tissue adhesion

    Directory of Open Access Journals (Sweden)

    Beatriz Simões Corrêa

    2005-12-01

    Full Text Available OBJETIVO: Medir a extensão de aderências mioesclerais no quadragésimo dia de pós-operatório. MÉTODOS: Quinze coelhos da raça Nova Zelândia foram distribuídos em três grupos de cinco coelhos, submetidos à operação de desinserção do músculo reto superior de ambos os olhos, e reposicionamento no local da inserção original: o Grupo SP para o controle, sutura com fio de poliglactina 910 (Vicryl® 6-0, Grupo AF, adesivo de fibrina (Beriplast-P®, e Grupo AC, adesivo de cianoacrilato (Histoacryl®. Antes da desinserção muscular, foram medidas as distâncias do gancho sob o músculo ao limbo, borda medial e lateral. Após quarenta e cinco dias, estes olhos foram reoperados e as medidas realizadas novamente. RESULTADOS: Não houve diferença significativa entre os adesivos estudados, quanto à adesão tecidual e às distâncias encontradas do músculo ao limbo nos pré- e pós-operatórios. CONCLUSÕES: As aderências teciduais encontradas foram provavelmente devidas aos processos de cicatrização, não dependendo dos materiais estudados.PURPOSE: Measure the extent of mioscleral adhesion on the fourtieth postoperative day. METHODS: Fifteen New Zealand rabbits were divided into three groups of five rabbits. They were operated on to server the insertion of the rectus muscle in the eye and then to reinsert it. Group SP, polyglactin (Vicryl® was used as control. In group AF, fibrin adhesive (Beriplast-P® was used, and in group AC, cyanoacrylate adhesive (Histoacryl®. Before severing muscle insertion, the distances between the muscle attachments of the limbus to the medial and lateral borders were measured. After forty-five days, the operation was again performed and the measurements were taken once more. RESULTS: There was no significant difference between the studied adhesives in terms of tissue adhesion and of the distances from the muscle to the limbus before and after surgery. CONCLUSION: The found tissue adhesion was probably due

  8. Who Does Extra-Credit Work in Introductory Science Courses?

    Science.gov (United States)

    Moore, Randy

    2005-01-01

    On the first day of classes, 81% of students in an introductory biology course claimed that they would submit extra-credit work if given the opportunity. When given two chances for extra-credit work, fewer than one-fourth of students submitted one or both assignments. Students who submitted extra-credit work were more likely to attend class,…

  9. Alergia ocular: un reto diagnóstico Ocular allergy: a diagnostic challenge

    Directory of Open Access Journals (Sweden)

    Ricardo Cardona Villa

    2007-12-01

    Full Text Available El ojo es uno de los órganos más sensibles y está permanentemente expuesto a diversos agentes ambientales. Dado que la conjuntiva es un tejido inmunológicamente activo, no es sorprendente que sea un sitio común de respuestas alérgicas. Las alergias oculares son un grupo de enfermedades que afectan la superficie conjuntival y están asociadas usualmente a reacciones de hipersensibilidad tipo 1. Pueden ser divididas en varias categorías: conjuntivitis alérgica estacional, conjuntivitis alérgica perenne, queratoconjuntivitis vernal y queratoconjuntivitis atópica. La inflamación de la superficie ocular produce prurito, lagrimeo, edema conjuntival y fotofobia. Como en otras enfermedades alérgicas, se puede desarrollar una condición crónica, acompañada de remodelación de los tejidos oculares. Las estrategias para el tratamiento de la alergia ocular han aumentado exponencialmente y los clínicos disponen de un inventario cada vez mayor de agentes dirigidos a la protección del ojo contra la inflamación. En este trabajo presentamos una revisión sobre las principales formas de alergia ocular, haciendo énfasis en el cuadro clínico, el diagnóstico y las nuevas opciones terapéuticas disponibles en la actualidad. The eye, one of the most sensitive organs, is permanently exposed to different environmental agents. Since the conjunctiva is an immunologically active tissue, it is not surprising for it to be a common site for allergic responses. Ocular allergies constitute a group of diseases affecting the conjunctival surface; they are usually associated with type 1 hypersensitivity reactions. This disorder can be divided into several categories: seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal keratoconjunctivitis and atopic keratoconjunctivitis. Ocular surface inflammation results in itching, tearing, conjunctival edema, and photophobia. As is the case with other allergic diseases, a chronic situation can also

  10. We are not alone: a case for the human microbiome in extra intestinal diseases.

    Science.gov (United States)

    Shivaji, S

    2017-01-01

    "Dysbiosis" in the gut microbiome has been implicated in auto-immune diseases, in inflammatory diseases, in some cancers and mental disorders. The challenge is to unravel the cellular and molecular basis of dysbiosis so as to understand the disease manifestation. Next generation sequencing and genome enabled technologies have led to the establishment of the composition of gut microbiomes and established that "dysbiosis" is the cause of several diseases. In a few cases the cellular and molecular changes accompanying dysbiosis have been investigated and correlated with the disease. Gut microbiome studies have indicated that Christensenella minuta controls obesity in mice, Faecalibacterium prausnitzii protects mice against intestinal inflammation and Akkermansia muciniphila reverses obesity and insulin resistance by secreting endocannabinoids. In mice polysaccharide antigen A on the surface of Bacteroides fragilis, reduces inflammation. Such experiments provide the link between the gut microbiome and human health but implicating dysbiosis with extra-intestinal diseases like arthritis, muscular dystrophy, vaginosis, fibromyalgia, some cancers and mental disorders appears to be more challenging. The relevance of gut microbiome to the eye appears to be very remote. But considering that the eye is the site of inflammatory diseases like uveitis, scleritis, Mooren's corneal ulcer etc. it is possible that these diseases are also influenced by dysbiosis. In mice signals from the gut microbiota activate retina specific T cells that are involved in autoimmune uveitis. Such information would open up new strategies for therapy where the emphasis would be on restoring the diversity in the gut by antibiotic or specific drug use, specific microbe introduction, probiotic use and fecal transplant therapy. The ocular surface microbiome may also be responsible for eye diseases in man but such studies are lacking. Microbiome of the healthy cornea and conjunctiva have been identified. But

  11. Estimation of ocular rigidity in glaucoma using ocular pulse amplitude and pulsatile choroidal blood flow.

    Science.gov (United States)

    Wang, Jing; Freeman, Ellen E; Descovich, Denise; Harasymowycz, Paul J; Kamdeu Fansi, Alvine; Li, Gisele; Lesk, Mark R

    2013-03-07

    Theoretical models and animal studies have suggested that scleral rigidity plays an important role in the pathogenesis of glaucoma. The aim of this study was to present a noninvasive technique for estimating ocular rigidity (E) in vivo, and to compare the estimated rigidity between patients with open-angle glaucoma (OAG); ocular hypertension (OHT); suspect glaucomatous disc (GS); and normal subjects (N). We hypothesized that OHT patients would have higher rigidity. All patients underwent measurements of ocular pulse amplitude (OPA) using dynamic contour tonometry, pulsatile choroidal blood flow (ChBFP) using laser Doppler flowmetry; axial length (AL); and assessment of automated visual field mean deviation (MD). The ratio between OPA and ChBFP was calculated according to the Friedenwald's equation of ocular rigidity. The calculated ratio is denoted as (ER). The average ER values of the four diagnostic groups were compared using nonparametric tests. The relationship between ER and other ocular and systemic factors was examined using correlation and regression analysis. A total of 257 subjects were included in the study (56 N, 108 OAG, 48 GS, and 45 OHT). ER correlated negatively with AL and positively with MD, signifying that a lower rigidity was associated with a longer eye and a worse (more negative) MD. ER was also found to be highest in OHT (0.235 ± 0.16) and lowest in OAG (0.188 ± 0.14; P = 0.01). Estimated coefficient of ocular rigidity by OPA and ChBFP suggested that glaucoma patients had the lowest rigidity and OHT the highest. It supports the idea that a more compliant ocular shell may predispose the optic nerve head to intraocular pressure (IOP)-related damage.

  12. Periorbital muscle atrophy associated with topical bimatoprost therapy

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    Wang PX

    2014-01-01

    Full Text Available Priscilla Xinhui Wang, Victor Teck Chang Koh, Jin Fong ChengDepartment of Ophthalmology, National University Health System, SingaporeAbstract: Topical Bimatoprost is a common and popular prostaglandin analog used as an ocular hypotensive agent in the treatment of glaucoma. Side effects include ocular hyperaemia, ocular pruritus, and periocular and iris pigmentary changes. Perioribital lipodystrophy is another well-documented outcome associated with chronic use of topical bimatoprost, which results in periorbital hallowing, upper eyelid sulcus deepening, eyelid retraction and enophthalmos. We report an unusual case of periocular muscle atrophy and weakness from unilateral topical bimatoprost use. Our patient had primary angle closure and experienced a right upper eyelid ptosis 2 months after she started to use topical bimatoprost in that eye. Clinical measurements of her eyelids clearly showed reduction in the function of her right levator muscle, suggesting that effects of topical bimatoprost may not be limited to periorbital fat. She was advised to stop topical bimatoprost and right ptosis correction surgery with levator muscle advancement was performed successfully. Ophthalmologists and patients should be aware of this potential rare side effect of topical bimatoprost, as it may be potentially disfiguring, especially with monocular use. However, its exact mechanism of action needs to be clarified further.Keywords: prostaglandin analog, levator, muscle atrophy, muscle weakness, ptosis, side effects

  13. Extra-adrenal Pheochromocytoma in an Adolescent

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    Abdullah, Ibrahim

    2011-05-01

    Full Text Available A 17-year-old male with symptoms of headache and diaphoresis presented to the emergency department. He had eight months of noted hypertension attributed to medications. On arrival his blood pressure was 229/117mmHg, and he was ill-appearing. His blood pressure was managed aggressively, and he was diagnosed with extra-adrenal pheochromocytoma by computed tomography. He eventually underwent resection of the mass. Children with severe, symptomatic hypertension should be evaluated for pheochromocytoma. Although rare, it is curable. Failure to diagnose carries a high risk of morbidity and mortality. [West J Emerg Med. 2011;12(2:258-261.

  14. Aneurisma micotico de origem extra-vascular

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    Nelson Pires Ferreira

    1976-12-01

    Full Text Available É relatado o caso de uma paciente com três anos de idade portadora de oftalmoplegia completa unilateral e aneurisma da artéria carótida interna, em sua porção intra-cavernosa. A etiologia infecciosa extra-vascular, na vigência de tromboflebite de seio cavernoso, foi considerada. As informações da literatura são discutidas, sendo comentada a infrequência da patologia. A indicação de ligadura da artéria carótida interna, no tratamento desses aneurismas, merece ulterior comprovação.

  15. Enhanced gravitational scattering from large extra dimensions

    CERN Document Server

    Koyama, K; Wands, D; Koyama, Kazuya; Piazza, Federico; Wands, David

    2005-01-01

    We show that enhanced gravitational scattering on small scales (< 0.1 mm), which becomes possible in models with large extra dimensions, can establish statistical equilibrium between different particle species in the early Universe. Ultra-light WIMPs (e.g., axions) can be thermalized by such a mechanism and therefore are not viable CDM candidates in models with a fundamental Planck scale below about 10 TeV. More generally we note that the energy transfer rate is sensitive to trans-Planckian physics

  16. Radio communications with extra-terrestrial civilizations

    Science.gov (United States)

    Kotelnikov, V. A.

    1974-01-01

    Communications between civilizations within our galaxy at the present level of radio engineering is possible, although civilizations must begin to search for each other to achieve this. If an extra-terrestrial civilization possessing a technology at our level wishes to make itself known and will transmit special radio signals to do this, then it can be picked up by us at a distance of several hundreds of light years using already existing radio telescopes and specially built radio receivers. If it wishes, this civilization can also send us information without awaiting our answer.

  17. Clinical utility and differential effects of prostaglandin analogs in the management of raised intraocular pressure and ocular hypertension

    Directory of Open Access Journals (Sweden)

    Anne J Lee

    2010-07-01

    Full Text Available Anne J Lee1,2, Peter McCluskey2,31Manchester Royal Eye Hospital, Manchester, UK; 2University of Sydney, Sydney, Australia; 3Sydney Eye Hospital, Sydney, AustraliaAbstract: Prostaglandin analogs (PGA are powerful topical ocular hypotensive agents available for the treatment of elevated intraocular pressure (IOP. Latanoprost 0.005% and travoprost 0.004% are prodrugs and analogs of prostaglandin F2a. Bimatoprost 0.03% is regarded as a prostamide, and debate continues as to whether it is a prodrug. The free acids of all 3 PGAs reduce IOP by enhancing uveoscleral and trabecular outflow via direct effects on ciliary muscle relaxation and remodeling of extracellular matrix. The vast majority of clinical trials demonstrate IOP-lowering superiority of latanoprost, bimatoprost and travoprost compared with timolol 0.5%, brimonidine 0.2%, or dorzolamide 2% monotherapy. Bimatoprost appears to be more efficacious in IOP-lowering compared with latanoprost, with weighted mean difference in IOP reduction documented in one meta-analysis of 2.59% to 5.60% from 1- to 6-months study duration. PGAs reduce IOP further when used as adjunctive therapy. Fixed combinations of latanoprost, bimatoprost or travoprost formulated with timolol 0.5% and administered once daily are superior to monotherapy of its constituent parts. PGA have near absence of systemic side effects, although do have other commonly encountered ocular adverse effects. The adverse effects of PGA, and also those found more frequently with bimatoprost use include ocular hyperemia, eyelash growth, and peri-ocular pigmentary changes. Iris pigmentary change is unique to PGA treatment. Once daily administration and near absence of systemic side effects enhances tolerance and compliance. PGAs are often prescribed as first-line treatment for ocular hypertension and open-angle glaucoma.Keywords: prostaglandin analog, glaucoma, ocular hypertension, latanoprost, bimatoprost, travoprost

  18. Isolated ocular lichen planus in a child.

    Science.gov (United States)

    Igras, Estera; Kennedy, Susan; MacDermott, Emma Jane; Murphy, Conor C

    2015-08-01

    Lichen planus (LP) is an autoimmune inflammatory condition of the skin and mucous membranes, of unknown aetiology, that infrequently involves the eye. Ocular LP has not been described in children. We present the case of an 8-year-old girl with severe, filamentous dry eyes and persistent conjunctival hyperemia with bilateral progressive conjunctival symblepharon. Her conjunctival biopsy showed heavy linear fibrinogen deposits along the basement membrane without IgG, IgA, IgM, or C3 deposition, consistent with LP. No skin or other mucosal lesions were present, suggesting a diagnosis of isolated conjunctival LP. Oral and topical cyclosporine combined with methotrexate and low-dose oral steroids led to sustained disease remission. To our knowledge, this is the first case of isolated ocular LP in a child.

  19. [Ocular hypertension in herpes simplex keratouveitis].

    Science.gov (United States)

    Burcea, M; Avram, Corina-Ioana; Stamate, Alina-Cristina; Malciolu, R; Oprea, S; Zemba, M

    2014-01-01

    The herpes simplex virus is one of the most common pathogens in humans, who are seropositive for the virus in 90% of the cases at the adult age. It determines reccurent infections in more than a third of the population and these infections depend on the immune response of the host. Ocular infections of newborns are due to the herpes simplex virus type 2, meanwhile type 1 is found predominantly at adults; almost all ocular structures can be affected. HSV-1 in the most frequent etiologic agent in infectious anterior uveitis (with the varicelo-zosterian virus) and it is responsible for 6-10% of all cases of anterior uveitis. More than half of the keratouveitides due to HSV will develop intraocular hypertension and open-angle secondary glaucoma, during reccurences and most of them will resolve after proper control of inflammation.

  20. [Conjunctival microbiota in patients with ocular allergy].

    Science.gov (United States)

    Libório, Alexandre Mattoso; Nishiwaki-Dantas, Maria Cristina; Mimica, Lycia Mara Jenne; Dantas, Paulo Elias Correa; Lima, Ana Luísa Höfling de

    2005-01-01

    To evaluate de presence of conjunctival aerobic microbiota in patients with ocular allergy as compared to a control group. One hundred and thirty-three patients were evaluated from April to June 2001 and divided into 2 groups. Sixty-three patients with allergic conjunctivitis (without medication) were in group A and 70 patients from the general outpatient clinic were in group B (control group). Samples from the conjunctival sac of the right eye were collected and cultured in solid media (blood, chocolate and Sabouraud agar). In group A, 30 cultures (47.7%) were positive and 6 (8.6%) in group B. Seven bacteria were isolated from group A and 4 from group B. Statistical analysis revealed significant association between positive cultures and allergic conjunctivitis. Bacterial microbiota was more frequently found in patients with ocular allergy.

  1. Ocular Surface as Barrier of Innate Immunity

    Science.gov (United States)

    Bolaños-Jiménez, Rodrigo; Navas, Alejandro; López-Lizárraga, Erika Paulina; de Ribot, Francesc March; Peña, Alexandra; Graue-Hernández, Enrique O; Garfias, Yonathan

    2015-01-01

    Sight is one of the most important senses that human beings possess. The ocular system is a complex structure equipped with mechanisms that prevent or limit damage caused by physical, chemical, infectious and environmental factors. These mechanisms include a series of anatomical, cellular and humoral factors that have been a matter of study. The cornea is not only the most powerful and important lens of the optical system, but also, it has been involved in many other physiological and pathological processes apart from its refractive nature; the morphological and histological properties of the cornea have been thoroughly studied for the last fifty years; drawing attention in its molecular characteristics of immune response. This paper will review the anatomical and physiological aspects of the cornea, conjunctiva and lacrimal apparatus, as well as the innate immunity at the ocular surface. PMID:26161163

  2. Amniotic membrane transplantation for acute ocular burns.

    Science.gov (United States)

    Clare, Gerry; Suleman, Hanif; Bunce, Catey; Dua, Harminder

    2012-09-12

    Ocular surface burns can be caused by chemicals (alkalis and acids) or by direct heat. Amniotic membrane transplantation (AMT) performed in the acute phase (day 0 to day 7) of an ocular surface burn is reported to relieve pain, accelerate healing and reduce scarring and blood vessel formation. The surgery involves applying a patch of amniotic membrane (AM) over the entire ocular surface up to the eyelid margins. To assess the effects of AMT on the eyes of people having suffered acute ocular surface burns. We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2012, Issue 6), MEDLINE (January 1946 to June 2012), EMBASE (January 1980 to June 2012), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to June 2012), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 11 June 2012. We included randomised trials of medical therapy and AMT applied in the first seven days after an ocular surface burn compared to medical therapy alone. Two authors independently assessed the risk of bias of included studies and extracted relevant data. We contacted trial investigators for missing information. We summarised data using risk ratios (RRs) and mean differences (MDs) as appropriate. We included one RCT of 100 participants with ocular burns that were randomised to treatment with AMT and medical therapy or medical therapy alone. A subset of patients (n = 68) who were treated within the first seven days of the injury met the inclusion criteria and were included in the analysis. The remaining 32 eyes were excluded. The included subset consisted of 36 moderate (Dua classification II-III) and 32 severe (Dua

  3. The formulation of drug for ocular administration.

    Science.gov (United States)

    Aiache, J M; el Meski, S; Beyssac, E; Serpin, G

    1997-01-01

    The different barriers that slow the penetration of active ingredients administered by the ocular route are described, and some novel dosage forms designed for this route are discussed. Both precorneal and corneal factors considerably restrict ocular penetration. The low bioavailability of classical ophthalmic dosage forms can be improved by several approaches, particularly by increasing the time the active ingredients remain in contact with the eye tissues. The new dosage forms are reviewed according to their type and their drug release mechanisms. The characteristics, advantages, and limitations of each are outlined. The potential of these dosage forms can be expected to enhance development. They offer prolonged effectiveness, reproducibility, fewer unwanted side effects, and improved tolerance.

  4. Partial unilateral lentiginosis with ocular involvement.

    Science.gov (United States)

    Schaffer, J V; Lazova, R; Bolognia, J L

    2001-02-01

    Partial unilateral lentiginosis (PUL) is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin; the pigmented macules are often in a segmental distribution with a sharp demarcation at the midline. We report the first case of ocular involvement in a patient with this diagnosis. The patient, a 30-year-old Peruvian woman, had multiple brown macules on the left upper face in primarily a V1 and V2 distribution with a sharp demarcation at the midline of the forehead. The lesions first appeared near the hairline when she was 5 years of age, and then began to extend onto the face. She also had a discrete area of brown pigmentation on the left lateral bulbar conjunctiva. Because the patient had been previously diagnosed by several dermatologists as having either a speckled lentiginous nevus or a nevus of Ota, we draw attention to the entity PUL and the possibility of ocular involvement.

  5. Ocular preservatives: associated risks and newer options.

    Science.gov (United States)

    Kaur, Indu Pal; Lal, Shruti; Rana, Cheena; Kakkar, Shilpa; Singh, Harinder

    2009-01-01

    Presence of a preservative in an ocular medication has often been considered a culprit in damaging the epithelium. However, the inclusion of a preservative is equally necessary, especially in multiple-dose containers, in order to protect against dangerous organisms accidentally gaining access during instillation. Benzalkonium chloride (BAK), chlorobutanol, chlorhexidine acetate (CHA), and phenylmercuric nitrate or acetate are some commonly used preservatives in eye preparations. New preservatives with a wide range of activity and good safety profiles have been introduced in the market, such as stabilized oxychloro complex (SOC), sofZia, and sodium perborate. In the present review, we discuss various conventional and newly proposed and patented preservative molecules for ocular use. Reasons for discontinuing traditional preservatives and the need for less-toxic molecules are discussed at length, along with newer options coming up in this area.

  6. OCULAR MANIFESTATIONS OF VIRAL INFECTIONS IN CHILDREN

    Directory of Open Access Journals (Sweden)

    E. Yu. Markovа

    2016-01-01

    Full Text Available In case of viral infections, ophthalmologists, pediatricians and general practitioners should all be aware of ocular manifestations of these diseases. According to our observations, despite the presence of corneal disorders, in 95 percent of children changes were reversible and in 1.5 months visual acuity was high. Only in five percent of cases despite the intensive therapy, patients had bacterial complications, causing a decrease in visual acuity.The combined  efforts of infectious disease specialists and ophthalmologists as well as timely and proper treatment are required to reduce the inflammation symptoms and prevent complications. By adding Ophtalmoferon® medication to the complex therapy of ocular surface diseases we observed its high therapeutic efficacy and a good safety profile. This medication is available in the form of ready-to-use eye drops, unlike other antiviral agents, improving  its compliance in outpatients.

  7. Manifestaciones oculares de las enfermedades sistémicas Ocular manifestations of systemic diseases

    Directory of Open Access Journals (Sweden)

    J. Andonegui

    2008-01-01

    Full Text Available Existe un gran número de enfermedades sistémicas que pueden presentar en algún momento de su evolución manifestaciones oculares. Estas alteraciones pueden provocar sintomatología por sí mismas, pueden ayudar a diagnosticar la enfermedad sistémica que las originó o pueden servir para monitorizar el curso evolutivo de la misma. Se destacan las principales características de una serie de enfermedades sistémicas asociadas a patología ocular que serán estudiadas en detalle a lo largo de esta monografía.A great number of systemic diseases can exhibit ocular manifestations during their evolution. These ocular alterations may cause symptoms by themselves, but can also be useful in diagnosing or monitoring the evolution of the systemic condition. The main characteristics of several systemic diseases exhibiting some kind of ocular sign are highlighted. These diseases will be described in detail in this issue.

  8. A simplified technique for in situ excision of cornea and evisceration of retinal tissue from human ocular globe.

    Science.gov (United States)

    Parekh, Mohit; Ferrari, Stefano; Di Iorio, Enzo; Barbaro, Vanessa; Camposampiero, Davide; Karali, Marianthi; Ponzin, Diego; Salvalaio, Gianni

    2012-06-12

    Enucleation is the process of retrieving the ocular globe from a cadaveric donor leaving the rest of the globe undisturbed. Excision refers to the retrieval of ocular tissues, especially cornea, by cutting it separate from the ocular globe. Evisceration is the process of removing the internal organs referred here as retina. The ocular globe consists of the cornea, the sclera, the vitreous body, the lens, the iris, the retina, the choroid, muscles etc (Suppl. Figure 1). When a patient is suffering from corneal damage, the cornea needs to be removed and a healthy one must be transplanted by keratoplastic surgeries. Genetic disorders or defects in retinal function can compromise vision. Human ocular globes can be used for various surgical procedures such as eye banking, transplantation of human cornea or sclera and research on ocular tissues. However, there is little information available on human corneal and retinal excision, probably due to the limited accessibility to human tissues. Most of the studies describing similar procedures are performed on animal models. Research scientists rely on the availability of properly dissected and well-conserved ocular tissues in order to extend the knowledge on human eye development, homeostasis and function. As we receive high amount of ocular globes out of which approximately 40% (Table 1) of them are used for research purposes, we are able to perform huge amount of experiments on these tissues, defining techniques to excise and preserve them regularly. The cornea is an avascular tissue which enables the transmission of light onto the retina and for this purpose should always maintain a good degree of transparency. Within the cornea, the limbus region, which is a reservoir of the stem cells, helps the reconstruction of epithelial cells and restricts the overgrowth of the conjunctiva maintaining corneal transparency and clarity. The size and thickness of the cornea are critical for clear vision, as changes in either of them

  9. [Larva migrans syndrome or ocular toxocariasis].

    Science.gov (United States)

    Pizzi, D R; Maffrand, R A; De Lisa, I S; Pizzi, H L; Plaza Ontiveros, R G

    2001-01-01

    Thirteen cases of ocular toxocariasis attended in the Oftalmology Service of the Pediatric Hospital "Niño Jesús", from Córdoba; and in the Parasitology and Micology Cathedra of the Medicine Collegue of the University of Córdoba were studied from July 1993 till July 1995. The authors determine the needs of taking into account this parasitosis; above all in children and with the antecedent of contact with pets.

  10. [Epstein Barr and cytomegaloviruses in ocular pathology].

    Science.gov (United States)

    Magdei, Corina; Cuşnir, Valeriu; Bârcâ, Ludmila

    2010-01-01

    Epstein-Barr virus (EBV) and Citomegalovirus (CMV) are Herpesviridae family representative and presents a real danger for human. A very high infect risk of population farther the danger The ocular pathology induced by them can affect all media and tunics of optic analyzer. An etiologic differentiation is necessary for the mentioned viruses induced diseases. The etiologic differentiation has like purpose the enforcement of an effective and optimal antiviral and immunomodulating therapy.

  11. Vitamin D in ocular and systemic health

    Directory of Open Access Journals (Sweden)

    Solani D. Mathebula

    2015-03-01

    Full Text Available Accumulated data supports the argument that vitamin D possesses several biological and molecular actions apart from its role in calcium absorption and facilitation of gene expression. Vitamin D deficiency has been an associated risk factor for cardiovascular disease,metabolic syndrome and ocular complications. The aim of this review is to summarise the most relevant data regarding these associations and to try to clarify whether, and to what extent, oral vitamin D supplementation could be used as a beneficial intervention in such diseases.Vitamin D is produced in skin exposed to sunlight UVB radiation and is then metabolised by the kidney into calciferol, which is an active form. The main function of vitamin D is to promote calcium and phosphorus absorption, and studies have shown that a lack of itplays an important role in ocular conditions, such as age-related macular degeneration and diabetic retinopathy. Recent studies have suggested that vitamin D may protect the diabetic retina; however, other vitamin D-associated conditions (diabetes, hypertension and cardiovascular diseases may result in secondary ocular manifestations and the potential forsight-threatening complications. The purpose of this review is to describe the current literature on the role of vitamin D in ocular and systemic wellness. However, more research is needed to determine if increasing levels of this vitamin can assist in preventing age-related macular degeneration or diabetic retinopathy. Since vitamin D is a circulating steroid hormone, its receptors are found in almost every cell in the human body, and this suggests that vitamin D might have a very broad role for overall health. However, there is still demand for further research to clarify the clinical use of vitamin D in the prevention and treatment of various chronic diseases.

  12. Neuroretinitis in ocular bartonellosis: a case series

    OpenAIRE

    Raihan AR; Zunaina E; Wan-Hazabbah WH; Adil H; Lakana-Kumar T

    2014-01-01

    Abdul-Rahim Raihan,1 Embong Zunaina,1,2 Wan-Hitam Wan-Hazabbah,1,2 Hussein Adil,1,2 Thavaratnam Lakana-Kumar1 1Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; 2Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, MalaysiaAbstract: We report a case series of neuroretinitis in ocular bartonellosis and describe the serologic verification for Bartonella henselae. This is a retrospective interventional case series of fo...

  13. Pharmacological consequences of oxidative stress in ocular tissues

    Energy Technology Data Exchange (ETDEWEB)

    Ohia, Sunny E. [Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, 141 Science and Research Building 2, University of Houston, Houston, TX 77204 (United States)]. E-mail: seohia@uh.edu; Opere, Catherine A. [Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178 (United States); LeDay, Angela M. [Professional and Scientific Relations, Procter and Gamble Pharmaceuticals Inc., Mason, OH 45040 (United States)

    2005-11-11

    The eye is a unique organ because of its constant exposure to radiation, atmospheric oxygen, environmental chemicals and physical abrasion. That oxidative stress mechanisms in ocular tissues have been hypothesized to play a role in diseases such as glaucoma, cataract, uveitis, retrolental fibroplasias, age-related macular degeneration and various forms of retinopathy provides an opportunity for new approaches to their prevention and treatment, In the anterior uvea, both H{sub 2}O{sub 2} and synthetic peroxides exert pharmacological/toxicological actions tissues of the anterior uvea especially on the sympathetic nerves and smooth muscles of the iris-ciliary bodies of several mammalian species. Effects produced by peroxides require the presence of trace amounts of extracellular calcium and the functional integrity of mitochondrial calcium stores. Arachidonic acid metabolites appear to be involved in both the excitatory action of peroxides on sympathetic neurotransmission and their inhibitory effect on contractility of the iris smooth muscle to muscarinic receptor activation. In addition to the peroxides, isoprostanes (products of free radical catalyzed peroxidation of arachidonic acid independent of the cyclo-oxygenase enzyme) can also alter sympathetic neurotransmission in anterior uveal tissues. In the retina, both H{sub 2}O{sub 2} and synthetic peroxides produced an inhibitory action on potassium depolarization induced release of [{sup 3}H] D-aspartate, in vitro and on the endogenous glutamate and glycine concentrations in vivo. Effects caused by peroxides in the retina are mediated, at least in part, by second messengers such as nitric oxide, prostaglandins and isoprostanes. The ability of H{sub 2}O{sub 2} to alter the integrity of neurotransmitter pools from sympathetic nerves in the anterior uvea and glutaminergic nerves in the retina could underlie its role in the etiology of glaucoma.

  14. Extra-mammary findings in breast MRI

    Energy Technology Data Exchange (ETDEWEB)

    Rinaldi, Pierluigi; Costantini, M.; Belli, P.; Giuliani, M.; Bufi, E.; Fubelli, R.; Distefano, D.; Romani, M.; Bonomo, L. [Catholic University - Policlinic A. Gemelli, Department of Bio-Imaging and Radiological Sciences, Rome (Italy)

    2011-11-15

    Incidental extra-mammary findings in breast Magnetic Resonance Imaging (MRI) may be benign in nature, but may also represent a metastasis or another important lesion. We aimed to analyse the prevalence and clinical relevance of these unexpected findings. A retrospective review of 1535 breast MRIs was conducted. Only axial sequences were reassessed. Confirmation examinations were obtained in all cases. 285 patients had a confirmed incidental finding, which were located in the liver (51.9%), lung (11.2%), bone (7%), mediastinal lymph nodes (4.2%) or consisted of pleural/pericardial effusion (15.4%). 20.4% of incidental findings were confirmed to be malignant. Positive predictive value for MRI to detect a metastatic lesion was high if located within the bone (89%), lymph nodes (83%) and lung (59%), while it was low if located within the liver (9%) or if it consisted of pleural/pericardial effusion (6%). The axial enhanced sequence showed superior sensitivity to unenhanced images in detecting metastatic lesions, especially if only smaller ({<=}10 mm.) lesions were considered. The prevalence of metastatic incidental extra-mammary findings is not negligible. Particular attention should be to incidental findings located within the lung, bone and mediastinal lymph nodes. (orig.)

  15. Neutrino Mass Models in Extra Dimensions

    CERN Document Server

    Ng, J N

    2003-01-01

    Neutrinos play a crucial role in many areas of physics from very short distances to astrophysics and cosmology. It is a long held believe that they are good probes of physics at the GUT scale. Recent developments have made it clear that they can also be of fundamental importance for the physics of extra dimensions if these exist. Here we pedagogically review the construction of neutrino mass models in extra dimensions within the brane world scenarios. These models are usually nontrivial generalizations of their four dimensional counterparts. We describe the theoretical tools that have been forged and the new perpectives gained in this rapidly developing area. In particular we discuss the issues involve in building models without the use of right-handed singlets. It is very difficult to directly test the origin of neutrino masses in different models be it in four or more dimensions. We point out that different models give very different indirect signatures in the TeV region and in precision measurements.

  16. Neptune migration model with one extra planet

    CERN Document Server

    Yeh, Lun-Wen; 10.1016/j.icarus.2009.06.008

    2009-01-01

    We explore conventional Neptune migration model with one additional planet of mass at 0.1-2.0 Me. This planet inhabited in the 3:2 mean motion resonance with Neptune during planet migration epoch, and then escaped from the Kuiper belt when Jovian planets parked near the present orbits. Adding this extra planet and assuming the primordial disk truncated at about 45 AU in the conventional Neptune migration model, it is able to explain the complex structure of the observed Kuiper belt better than the usual Neptune migration model did in several respects. However, numerical experiments imply that this model is a low-probability event. In addition to the low probability, two features produced by this model may be inconsistent with the observations. They are small number of low-inclination particles in the classical belt, and the production of a remnant population with near-circular and low-inclination orbit within a = 50-52 AU. According to our present study, including one extra planet in the conventional Neptune ...

  17. Exploring extra dimensions with scalar waves

    CERN Document Server

    Jones-Smith, Katherine; Verostek, Michael

    2016-01-01

    This paper provides a pedagogical introduction to the physics of extra dimensions focussing on the ADD, Randall-Sundrum and DGP models. In each of these models, the familiar particles and fields of the standard model are assumed to be confined to a four dimensional space-time called the brane; the brane is a slice through a higher dimensional space-time called the bulk. The geometry of the ADD, Randall-Sundrum and DGP space-times is described and the relation between Randall-Sundrum and Anti-de-Sitter space-time is explained. The necessary differential geometry background is introduced in an appendix that presumes no greater mathematical preparation than multivariable calculus. The ordinary wave equation and the Klein-Gordon equation are briefly reviewed followed by an analysis of the propagation of scalar waves in the bulk in all three extra-dimensional models. We also calculate the scalar field produced by a static point source located on the brane for all three models. For the ADD and Randall-Sundrum model...

  18. Dynamical Electroweak Symmetry Breaking from Extra Dimensions

    CERN Document Server

    Hashimoto, M; Yamawaki, K; Hashimoto, Michio; Tanabashi, Masaharu; Yamawaki, Koichi

    2003-01-01

    We study the dynamical electroweak symmetry breaking (DEWSB) in the $D (=6,8,...)$-dimensional bulk with compactified extra dimensions. We identify the critical binding strength for triggering the DEWSB, based on the ladder Schwinger-Dyson equation. In the top mode standard model with extra dimensions, where the standard model gauge bosons and the third generation of quarks and leptons are put in the bulk, we analyze the most attractive channel (MAC) by using renormalization group equations (RGEs) of (dimensionless) bulk gauge couplings and determine the effective cutoff where the MAC coupling exceeds the critical value. We then find that the top-condensation can take place for D=8. Combining RGEs of top-Yukawa and Higgs-quartic couplings with compositeness conditions, we predict the top mass, $m_t=173-180$ GeV, and the Higgs mass, $m_H=181-211$ GeV, for D=8, where we took the universal compactification scale $1/R = 1-100$ TeV.

  19. Dynamical Electroweak Symmetry Breaking from Extra Dimensions

    Science.gov (United States)

    Hashimoto, Michio; Tanabashi, Masaharu; Yamawaki, Koichi

    2003-08-01

    We study the dynamical electroweak symmetry breaking (DEWSB) in the D(= 6, 8, ⋯)-dimensional bulk with compactified extra dimensions. We identify the critical binding strength for triggering the DEWSB, based on the ladder Schwinger-Dyson equation. In the top mode standard model with extra dimensions, where the standard model gauge bosons and the third generation of quarks and leptons are put in the bulk, we analyze the most attractive channel (MAC) by using renormalization group equations (RGEs) of (dimensionless) bulk gauge couplings and determine the effective cutoff where the MAC coupling exceeds the critical value. We then find that the top-condensation can take place for D = 8. Combining RGEs of top-Yukawa and Higgs-quartic couplings with compositeness conditions, we predict the top mass, mt = 173 - 180 GeV, and the Higgs mass, mH = 181 - 211 GeV, for D = 8, where we took the universal compactification scale 1/R = 1 - 100 TeV.

  20. Extra-Galactic Diffuse Interstellar Bands

    Science.gov (United States)

    Cox, N.; Ehrenfreund, Pascale; Kaper, Lex; Spaans, Marco; Foing, Bernard

    Diffuse Interstellar Bands (DIBs) have been observed ubiquitously along many sight-lines probing the interstellar medium of the Milky Way. Despite extensive efforts, their carrier(s) have not yet been identified, although they are very likely of a carbonaceous nature and reside in the gas phase. Possible candidates include, but are not limited to, polycyclic aromatic hydro- carbons (PAHs), fullerenes and carbon chains. To advance our understanding of DIB behaviour and thus DIB carrier properties we need to study environments inherently different from those observed in the Milky Way. Only recent advances in instrumentation and telescope capabilities are providing us with new exciting possibilities for extra-galactic DIB research. We present here a selection of our recent observational results for (extra)-galactic DIBs in the Local Group and beyond. In particular, DIBs in the Magellanic Clouds and in the spiral galaxy NGC1448. These first results show surprising similarities between certain DIB profiles as well as differences in DIB behaviour. Understanding diffuse cloud chemistry, in particular with respect to complex (carbonaceous) molecules, is crucial to any DIB carrier identification. In this respect, external galaxies offer a unique window as they exhibit local interstellar conditions (such as metallicity, UV-field and gas-to-dust ratio) very different from those observed in the Milky Way. We discuss briefly the effect of metallicity and the gas-to-dust ratio on the physi-chemical properties of diffuse clouds and the subsequent effects on the PAH charge state distribution and the DIB carriers.

  1. [Extra-articular manifestations of seronegative spondylarthritis].

    Science.gov (United States)

    Cammelli, Daniele

    2006-05-01

    Seronegative spondylarthritis are frequently characterised by extra-articular manifestations. They are frequently in recurrent uveitis. Between the cutaneous manifestations should be mentioned erythema nodosum, typical of inflammatory bowel diseases, and keratoderma blenorrhagicum, in the Reiter's syndrome. Cardiac complications in ankylosing spondylitis (AS) include aortic valvular regurgitation and arrhythmia and, more rarely, mitral valvulopathy, cardiomyopathy and pericarditis. Pulmonary involvement in AS includes ventilatory restrictive syndrome and fibro-bullous disease of the apex. Vertebral osteoporosis is a very important extra-articular manifestation because of the possibility of spontaneous fractures of the vertebrae. Central neurological manifestations include medullary compression from cervical sub-luxation while the most important peripheral involvements are lumbar stenosis and the cauda equina syndrome. Type AA amyloidosis is a rare late complication of the AS, possible cause of death especially in patients with aggressive disease. Kidney complications can be observed as consequences of prolonged anti-inflammatory therapy, but the most frequent renal complications are amyloidosis and mesangial IgA segmental and focal glomerulonephritis.

  2. Gauge symmetries emerging from extra dimensions

    Science.gov (United States)

    Chkareuli, J. L.; Kepuladze, Z.

    2016-09-01

    We argue that extra dimensions with a properly chosen compactification scheme could be a natural source for emergent gauge symmetries. Actually, some proposed vector field potential terms or polynomial vector field constraints introduced in five-dimensional Abelian and non-Abelian gauge theory are shown to smoothly lead to spontaneous violation of an underlying 5D spacetime symmetry and generate pseudo-Goldstone vector modes as conventional 4D gauge boson candidates. As a special signature, there appear, apart from conventional gauge couplings, some properly suppressed direct multiphoton (multiboson, in general) interactions in emergent QED and Yang-Mills theories whose observation could shed light on their high-dimensional nature. Moreover, in emergent Yang-Mills theories an internal symmetry G also occurs spontaneously broken to its diagonal subgroups once 5D Lorentz violation happens. This breaking originates from the extra vector field components playing a role of some adjoint scalar field multiplet in the 4D spacetime. So, one naturally has the Higgs effect without a specially introduced scalar field multiplet. Remarkably, when being applied to grand unified theories (GUTs) this results in a fact that the emergent GUTs generically appear broken down to the Standard Model just at the 5D Lorentz violation scale M .

  3. The Universe’s extra bits

    CERN Multimedia

    CERN Bulletin

    2010-01-01

    Parallel universes, unknown forms of matter, extra dimensions….This is not cheap science fiction but very concrete physics theories that the scientists are trying to confirm with the LHC and other ongoing experiments. Although it's enough to make us dream about going to a parallel world for the weekend, let’s keep our feet firmly on the ground and try to work out what all these things really are…   Given the astonishing fact that 96% of the Universe is actually unknown, we can think of filling it with all sorts of weird and exotic things. Extra dimensions and parallel universes may indeed be real, that is, their existence is accepted by a large community of scientists who have worked out mathematical models and physical constraints. “The idea of a fifth dimension was first introduced by Kaluza and Klein at the beginning of the last century in an attempt to unify gravity and electromagnetism”, confirms Ignatios Antoniadis from CERN’s Th...

  4. Ocular pathology in congenital heart disease.

    Science.gov (United States)

    Mansour, A M; Bitar, F F; Traboulsi, E I; Kassak, K M; Obeid, M Y; Megarbane, A; Salti, H I

    2005-01-01

    To describe the ocular findings in subjects with congenital heart disease (CHD). In a prospective study, the same observer examined 240 consecutive patients with CHD admitted to the medical centre. Two independent geneticists performed identification of syndromes. The commonest anatomic cardiac anomalies were ventricular or atrial septal defects (62), tetralogy of Fallot (39), pulmonary stenosis (25), and transposition of the great arteries (24). The heart lesions were divided physiologically into volume overload (90), cyanotic (87), and obstructive (63). In all, 105 syndromic subjects included the velocardiofacial syndrome (18), Down's syndrome (17), CHARGE association (6), DiGeorge syndrome (5), Williams syndrome (3), Edwards syndrome (3), Noonan syndrome (3), VACTERL association (2), and Patau syndrome (trisomy 13) (2). The paediatric team recognized 51 patients as syndromic. Two independent geneticists recognized additional 54 patients as syndromic. Positive eye findings were present in 55% (132) and included retinal vascular tortuosity (46), optic disc hypoplasia (30), trichomegaly (15), congenital ptosis (12), strabismus (11), retinal haemorrhages (8), prominent eyes (7), and congenital cataract (6). There was a strong correlation between the retinal vascular tortuosity and both a low haematocrit (P=0.000) and a low arterial oxygen saturation (P=0.002). Patients with CHD are at a high risk for ocular pathology and need screening for various ocular abnormalities.

  5. Experimental models of autoimmune inflammatory ocular diseases

    Directory of Open Access Journals (Sweden)

    Fabio Gasparin

    2012-04-01

    Full Text Available Ocular inflammation is one of the leading causes of blindness and loss of vision. Human uveitis is a complex and heterogeneous group of diseases characterized by inflammation of intraocular tissues. The eye may be the only organ involved, or uveitis may be part of a systemic disease. A significant number of cases are of unknown etiology and are labeled idiopathic. Animal models have been developed to the study of the physiopathogenesis of autoimmune uveitis due to the difficulty in obtaining human eye inflamed tissues for experiments. Most of those models are induced by injection of specific photoreceptors proteins (e.g., S-antigen, interphotoreceptor retinoid-binding protein, rhodopsin, recoverin, phosducin. Non-retinal antigens, including melanin-associated proteins and myelin basic protein, are also good inducers of uveitis in animals. Understanding the basic mechanisms and pathogenesis of autoimmune ocular diseases are essential for the development of new treatment approaches and therapeutic agents. The present review describes the main experimental models of autoimmune ocular inflammatory diseases.

  6. Ocular Blood Flow and Normal Tension Glaucoma

    Directory of Open Access Journals (Sweden)

    Ning Fan

    2015-01-01

    Full Text Available Normal tension glaucoma (NTG is known as a multifactorial optic neuropathy characterized by progressive retinal ganglion cell death and glaucomatous visual field loss, even though the intraocular pressure (IOP does not exceed the normal range. The pathophysiology of NTG remains largely undetermined. It is hypothesized that the abnormal ocular blood flow is involved in the pathogenesis of this disease. A number of evidences suggested that the vascular factors played a significant role in the development of NTG. In recent years, the new imaging techniques, fluorescein angiography, color Doppler imaging (CDI, magnetic resonance imaging (MRI, and laser speckle flowgraphy (LSFG, have been used to evaluate the ocular blood flow and blood vessels, and the impaired vascular autoregulation was found in patients with NTG. Previous studies showed that NTG was associated with a variety of systemic diseases, including migraine, Alzheimer’s disease, primary vascular dysregulation, and Flammer syndrome. The vascular factors were involved in these diseases. The mechanisms underlying the abnormal ocular blood flow in NTG are still not clear, but the risk factors for glaucomatous optic neuropathy likely included oxidative stress, vasospasm, and endothelial dysfunction.

  7. PAEDIATRIC OCULAR TRAUMA IN KUCHING, SARAWAK, MALAYSIA

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    INTAN G

    2011-01-01

    Full Text Available Purpose: To evaluate the demography, aetiology, type and outcome of paediatric ocular trauma in tertiary centre in Malaysia. Method: We retrospectively studied 118 eyes from 117 patients over a period of 36 months (January 2006 to December 2008. All ocular injuries in patients aged 12 and below seen in the Ophthalmology Department for the first time were included in thisstudy. Results: Mean age of patients was 6.1±3.0 years. 68 cases (58.2% occurred in pre-school children, whereas 49 (41.9% in school-aged children. Boys accounted for 65.8% of cases. There was no predilection for either right or the left eye. 47% of cases (56 patients occurred in Malay. Most of the injuries took place at home when the children were alone (p<0.05. Sharp objects were the commonest cause (45 cases, 38.1%. The majority of cases (103, 87.3% were considered preventable. The frequency of open and closed globe injury was similar. Hyphema was more common in closed globe injury compared to open globe injury (p<0.05. Other associated injuries such as cataract, vitreous hemorrhage and retinal hemorrhage are similar between the two groups. Visual outcome is generally poor with only 34 eyes (28.8% had no visual impairment. Conclusion: Ocular trauma in children is an important cause of visual loss. Most cases occurred at home and were preventable. Prevention through education is the best approach.

  8. A CLINICAL STUDY OF OCULAR TRAUMA

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    Bharat Kumar

    2015-12-01

    Full Text Available AIM This study is designed to enumerate various causes of ocular trauma, clinical spectrum of presentation and to evaluate the visual outcome after appropriate management. MATERIALS AND METHODS A prospective study was conducted on total of 136 patients from the places in and around Kakinada, East Godavari District of Andhra Pradesh, India. A detailed work up of all patients including slit lamp biomicroscopy, direct, indirect ophthalmoscopy and ultra sonography B scan was done. RESULTS Observations from the study were analyzed, discussed and compared with the existing studies in the literature. Mean age group of patients belong to young adults between 20-30 years (57.9%, males (81% affected more than females. Illiterates, Agricultural labourers, Industrial workers affected more. Road Traffic Accidents (25.73%, industrial injuries (22.05% and agricultural hazards (19.11% being the major cause of unilateral eye injury. Closed globe injuries (80.88% more common than Open globe injuries (19.12. CONCLUTIONS Ophthalmic injuries due to innumerable causes results in various types of ocular trauma, leading to untold misery, visual impairment and economic burden to the family, society and country as a whole. Health education regarding use of preventive measures, seeking early treatment and appropriate rehabilitation are very much recommended to reduce the burden of morbidity due to ocular trauma.

  9. Ocular Complications of Leprosy in Yemen

    Science.gov (United States)

    Salem, Raga A. A.

    2012-01-01

    Objectives: This study was conducted to identify the main ocular- and vision-threatening complications of leprosy in Yemen. Methods: This is a cross-sectional observational study which took place from February to July 2010. Leprosy patients attending the Skin and Venereal Diseases Hospital in the City of Light in Taiz, Yemen, who consented to participate in the study, were enrolled. Detailed demographic and medical histories were taken and clinical examination findings were recorded. A detailed eye examination, including visual acuity (VA), slit-lamp, and fundus examinations, was conducted on each patient by a qualified ophthalmologist. Results: A total of 192 patients (180 male, 12 female, with a male to female ratio of 15:1) were included in the study. The majority of the patients (157; 81.8%) were over 40 years. Over two-thirds of the patients (129; 67.2%) had had leprosy for more than 20 years. Ocular complications were found in 97% of cases; 150 (39.1%) of the patients’ eyes had at least one pathology. Eyelid involvement was the most common problem observed in 102 (26.5%) patients. Half of the eyes (192; 50%) had a VA of <6/60. The main cause of blindness among these patients was corneal opacity detected in 69 out of 192 patients (35.9%). Conclusion: Ocular complications are frequent among leprosy patients in Yemen. They are true vision-threatening lesions. It is important to prevent these lesions through early diagnosis and adequate treatment. PMID:23275842

  10. Neuroretinitis in ocular bartonellosis: a case series

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    Raihan AR

    2014-08-01

    Full Text Available Abdul-Rahim Raihan,1 Embong Zunaina,1,2 Wan-Hitam Wan-Hazabbah,1,2 Hussein Adil,1,2 Thavaratnam Lakana-Kumar1 1Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; 2Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, MalaysiaAbstract: We report a case series of neuroretinitis in ocular bartonellosis and describe the serologic verification for Bartonella henselae. This is a retrospective interventional case series of four patients who presented in the ophthalmology clinic of Hospital Universiti Sains Malaysia from June 2012 to March 2013. All four patients had a history of contact with cats and had fever prior to ocular symptoms. Each patient presented with neuroretinitis characterized by optic disc swelling with macular star. Serology analysis showed strongly positive for B. henselae in all of the patients. All patients were treated with oral azithromycin (except case 4, who was treated with oral doxycycline, and two patients (case 1 and case 3 had poor vision at initial presentation that warranted the use of oral prednisolone. All patients showed a good visual outcome except case 3. Vision-threatening ocular manifestation of cat scratch disease can be improved with systemic antibiotics and steroids.Keyword: cat scratch disease

  11. Seminal Vesicle Leiomyoma Mimicking Extra-prostatic Extension of Prostatic Adenocarcinoma.

    Science.gov (United States)

    Arnold, Stacy J; Lin, Frank C; Eldersveld, Jordan M; Phung, Michael C; Walker, Jonathan R; Nguyen, Tan T

    2016-05-01

    Leiomyomas are common smooth muscle neoplasms; however, leiomyomas of the seminal vesicles are extremely rare. We report a case of seminal vesicle leiomyoma in a 55-year-old African American male who underwent robot assisted laparoscopic prostatectomy (RALP) for Gleason 8 (4 + 4) adenocarcinoma. An incidental nodule arising from the left seminal vesicle was discovered during surgery, complicating the surgical dissection and suggesting extra-prostatic extension. The histologic findings in this case raised the possibility that this seminal vesicle leiomyoma may have arisen from a remnant of the mid-portion of the Müllerian duct; however, a thorough immunohistochemical (IHC) workup disproved this theory.

  12. Anterior transposition of the inferior oblique muscle as the initial treatment of a snapped inferior rectus muscle.

    Science.gov (United States)

    Aguirre-Aquino, B I; Riemann, C D; Lewis, H; Traboulsi, E I

    2001-02-01

    Snapping or tearing of an extraocular muscle refers to its rupture across its width, usually at the junction between muscle and tendon several millimeters behind the insertion. Tearing occurs during strabismus or retinal reattachment surgery, or after trauma. If the proximal end of the muscle cannot be located, transposition procedures are necessary to achieve ocular realignment. These surgical procedures carry the risk of anterior segment ischemia, especially in the elderly. Anterior transposition of the inferior oblique muscle has been used for the treatment of inferior oblique overaction, especially in the presence of a dissociated vertical deviation, and in patients with fourth nerve palsy. We transposed the inferior oblique muscle insertion in a 73-year-old woman with a snapped inferior rectus muscle.

  13. LEVANTAMENTO DOS CASOS DE TRAUMATISMO OCULAR NUM HOSPITAL DE EMERGÊNCIA

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    MARIA ALZETE DE LIMA

    2010-01-01

    Full Text Available Los objetivos del estudio fueron estimar la incidencia e identificar los tipos de traumas y las circunstancias relacionadas a los casos de los pacientes atendidos en un servicio de urgencia oftalmológica, Ceará, Brasil. Estudio descriptivo, cuantitativo, realizado con 845 víctimas de traumas. Se evaluó: sexo, edad, origen, causa y tipo de trauma. La recogida de datos fue llevada a cabo mediante entrevista y el registro del historial médico de los casos. El sexo masculino, 663(78,5% fue más susceptible a los traumas oculares, causados por cuerpo extraño, 321(40,89%, y accidente de tráfico, 147 (18,73%. En el sexo femenino prevaleció el accidente doméstico, 49 (40,2%. La mayoría pertenecía al rango de 20 a 29 años de edad, 196 (25,0%, y procedente de la capital, 530 (67,5%. La herida penetrante fue el principal tipo de trauma. Ante la magnitud del problema, es importante que se tomen medidas de promoción en salud que ayuden a prevenir los traumatismos oculares.

  14. Comparação entre os métodos de injeção de toxina botulínica em músculo ocular externo com o uso do eletromiógrafo e com o uso da pinça de Mendonça Electromyograph assistance and Mendonça's forceps - a comparison between two methods of botulinum toxin A injection into the extraocular muscle

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    Tomás Fernando Scalamandré Mendonça

    2005-04-01

    Full Text Available OBJETIVO: Comparar dois métodos de aplicação de toxina botulínica A (TBA em músculo ocular externo: com auxílio de eletromiógrafo (EMG e com a pinça de Mendonça. MÉTODOS: Foram analisados no Departamento de Oftalmologia da UNIFESP 29 pacientes que apresentavam estrabismo e baixa acuidade visual em um olho. Foram divididos em dois grupos: grupo I - 17 pacientes que receberam a toxina botulínica A por meio de injeção com auxílio da pinça de Mendonça e grupo II - 12 pacientes que receberam a toxina botulínica A por injeção guiada pelo eletromiógrafo. Os pacientes dos dois grupos foram avaliados no 7º e no 14º dia após aplicação. Compararam-se os resultados dos dois grupos neste período de tempo. Os testes de correlação de Friedman e Mann-Whitney foram usados para análise estatística. RESULTADOS: Houve diferença estatística entre as médias de desvio pré-aplicação e em pelo menos um período (7º ou 14º dia após aplicação, tanto no grupo dos pacientes em que foi utilizada a pinça, quanto no grupo de pacientes em que foi utilizado o eletromiógrafo. Não houve diferença estatística dos desvios pré-aplicação e pós-aplicação entre os dois grupos. CONCLUSÃO: Os dois métodos de aplicação da toxina botulínica A são equivalentes e portanto, o uso da pinça de Mendonça pode ser método alternativo ao uso do eletromiógrafo, para guiar a injeção de toxina botulínica A.PURPOSE: To compare two methods of botulinum toxin A (BTA injection into the extraocular muscle (EOM: the electromyographically (EMG guided injection and the injection using Mendonça's forceps. METHODS: Twenty-nine (29 patients with strabismus and low visual acuity in one eye were examined at the Department of Ophthalmology of UNIFESP. They were divided into 2 groups - group I with 17 patients receiving the botulinum toxin A injection using Mendonça's forceps, and group II with 12 patients receiving the toxin with electromyographical

  15. Dry Eye Management: Targeting the Ocular Surface Microenvironment.

    Science.gov (United States)

    Zhang, Xiaobo; M, Vimalin Jeyalatha; Qu, Yangluowa; He, Xin; Ou, Shangkun; Bu, Jinghua; Jia, Changkai; Wang, Junqi; Wu, Han; Liu, Zuguo; Li, Wei

    2017-06-29

    Dry eye can damage the ocular surface and result in mild corneal epithelial defect to blinding corneal pannus formation and squamous metaplasia. Significant progress in the treatment of dry eye has been made in the last two decades; progressing from lubricating and hydrating the ocular surface with artificial tear to stimulating tear secretion; anti-inflammation and immune regulation. With the increase in knowledge regarding the pathophysiology of dry eye, we propose in this review the concept of ocular surface microenvironment. Various components of the microenvironment contribute to the homeostasis of ocular surface. Compromise in one or more components can result in homeostasis disruption of ocular surface leading to dry eye disease. Complete evaluation of the microenvironment component changes in dry eye patients will not only lead to appropriate diagnosis, but also guide in timely and effective clinical management. Successful treatment of dry eye should be aimed to restore the homeostasis of the ocular surface microenvironment.

  16. Laser exposure analysis for a near-infrared ocular interferometer

    Science.gov (United States)

    Primeau, Brian C.; Goldstein, Goldie L.; Greivenkamp, John E.

    2012-06-01

    Ocular interferometry has potential value in a variety of ocular measurement applications, including measuring ocular thicknesses, topography of ocular surfaces or the wavefront of the eye. Of particular interest is using interferometry for characterizing corneal shape and irregular corneal features, making this technology attractive due to its inherent accuracy and spatial resolution. A particular challenge of designing an ocular interferometer is determining safe laser exposure levels to the eye, including both the retina and anterior segment. Described here are the laser exposure standards relevant in the interferometer design and the corresponding calculations and results. The results of this work can be used to aid in the design of similar laser-based systems for ocular evaluation.

  17. Dry Eye Management: Targeting the Ocular Surface Microenvironment

    Science.gov (United States)

    Zhang, Xiaobo; Jeyalatha M, Vimalin; Qu, Yangluowa; He, Xin; Ou, Shangkun; Bu, Jinghua; Jia, Changkai; Wang, Junqi; Wu, Han; Liu, Zuguo

    2017-01-01

    Dry eye can damage the ocular surface and result in mild corneal epithelial defect to blinding corneal pannus formation and squamous metaplasia. Significant progress in the treatment of dry eye has been made in the last two decades; progressing from lubricating and hydrating the ocular surface with artificial tear to stimulating tear secretion; anti-inflammation and immune regulation. With the increase in knowledge regarding the pathophysiology of dry eye, we propose in this review the concept of ocular surface microenvironment. Various components of the microenvironment contribute to the homeostasis of ocular surface. Compromise in one or more components can result in homeostasis disruption of ocular surface leading to dry eye disease. Complete evaluation of the microenvironment component changes in dry eye patients will not only lead to appropriate diagnosis, but also guide in timely and effective clinical management. Successful treatment of dry eye should be aimed to restore the homeostasis of the ocular surface microenvironment. PMID:28661456

  18. Ivermectin treatment of patients with severe ocular onchocerciasis.

    Science.gov (United States)

    Taylor, H R; Semba, R D; Newland, H S; Keyvan-Larijani, E; White, A; Dukuly, Z; Greene, B M

    1989-05-01

    The treatment of onchocerciasis with diethylcarbamazine and suramin is associated with an exacerbation of ocular disease. This occurs more frequently in patients with severe onchocercal ocular disease. We assessed ocular changes following ivermectin treatment in 39 patients with severe ocular onchocerciasis. Patients were treated with 100, 150, or 200 micrograms/kg of ivermectin at either 1 or 2 year intervals and followed for 3 years. There was no evidence for an acute exacerbation of either anterior or posterior segment eye disease, and there was a marked improvement in ocular status in the group as a whole. There was a significant decrease in onchocercal involvement which was maintained for at least 3 years. Annual treatment with ivermectin can be used safely in patients with severe ocular disease and is beneficial over a prolonged period of time.

  19. Study of ocular aberrations with age.

    Science.gov (United States)

    Athaide, Helaine Vinche Zampar; Campos, Mauro; Costa, Charles

    2009-01-01

    Aging has various effects on visual system. Vision deteriorate, contrast sensitivity decreases and ocular aberrations apparently make the optical quality worse across the years. To prospective evaluate ocular aberrations along the ages. Three hundred and fifteen patients were examined, 155 were male (39.36%) and 160 were female (60.63%). Ages ranged from 5 to 64 year-old, the study was performed from February to November, 2004. Patients were divided into 4 age-groups according to IBGE (Instituto Brasileiro de Geografia e Estatística) classification: 68 patients from 5 to 14 year-old, 55 patients from 15 to 24 year-old, 116 from 25 to 44 year-old and 76 from 45 to 67 year-old. All patients had the following characteristics: best corrected visual acuity > 20/25, emmetropia or spherical equivalent < 3.50 SD, refractive astigmatism < 1.75 CD on cycloplegic refraction, normal ophthalmologic exam and no previous ocular surgeries. This protocol was approved by Federal University of São Paulo Institutional Review Board. Total optical aberrations were measured by H-S sensor LadarWave Custom Cornea Wavefront System (Alcon Laboratories Inc, Orlando, FLA, USA) and were statistically analysed. Corneal aberrations were calculated using CT-View software Version 6.89 (Sarver and Associates, Celebration, FL, USA). Lens aberrations were calculated by subtraction. High-order (0.32 e 0.48 microm) and ocular spherical aberrations (0.02 e 0.26 microm) increased respectively in child and middle age groups. High order (0.27 microm) and corneal spherical aberrations (0.05 microm) did not show changes with age. Lens showed a statistically significant spherical aberration increase (from -0.02 to 0.22 microm). Vertical (from 0.10 to -0.07 microm) and horizontal coma (from 0.01 to -0.12 microm) presented progressively negative values with aging. High-order and spherical aberrations increased with age due to lens contribution. The cornea did not affect significantly changes observed on ocular

  20. Muscular and intraocular pressure responses among ocular-hypertensive subjects: is there a rationale for biofeedback?

    Science.gov (United States)

    Raczynski, J M; Mason, D A; Wilson, R P; Silvia, E S; Kleinstein, R N

    1985-12-01

    Several animal and human investigations have indicated that intraocular pressure (IOP) levels may be associated with extreme drug-induced changes in the extraocular muscles. Further, recent data suggest that, among individuals with normal IOP level, moderate increases in facial muscle (EMG) activity around the eye while the eye is open are associated with increases in IOP. To investigate further the relationship between facial EMG activity and IOP levels and to examine a group of individuals with elevated IOP levels, subjects were recruited from outpatients at an optometry clinic. Three groups of subjects were selected: a group of ocular hypertensive subjects who showed elevated pressures at the optometry clinic and upon the day of testing, a group of labile ocular hypertensive subjects who evinced elevated pressures during their visit to the optometry clinic but lower pressures on the day of testing, and a group of normal IOP subjects who showed normal pressures both during their optometry clinic visit and on the day of testing. To investigate anxiety differences, subjects were administered the State-Trait Anxiety Inventory, but subsequent analysis revealed no group differences. To evaluate the role of stress upon muscle (EMG) functioning around the eye, subjects were subjected to imagery and standardized mental arithmetic stressors; analyses of these results also revealed no significant group differences. Finally, subjects were given EMG biofeedback for muscle activity around the eye while IOP was assessed during five alternating periods in which they made decreases and increases in EMG activity. Results revealed significant group, period, and group by period interaction effects. The pattern of results is interpreted as implicating EMG activity in IOP fluctuations; the implications of these data for potential biofeedback and stress management treatments are discussed.

  1. Study of ocular manifestations in children of thalassemia

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    Dhara K. Gosai

    2014-04-01

    Conclusion: Most of the ocular changes of beta thalassemia are attributed to the course and severity of the disease. Reduction in serum iron and serum Ferritin levels by iron- chelating agents and regular ocular examination to look for side-effects of such agents can aid in preventing or delaying ocular complications. [Int J Res Med Sci 2014; 2(2.000: 695-698

  2. Study of ocular manifestations in children of thalassemia

    OpenAIRE

    Dhara K. Gosai; K. M. Mehariya; Jigarkumar B. Gosai

    2014-01-01

    Background: Purpose of current study was to study the ocular manifestations in beta-thalassemia major patients and assess the ocular side-effects of iron chelating agents. Methods: Cross sectional study included 45 beta Thalassemia major patients from age group of 6months to 12 years were taken. Full medical history, thorough physical examinations were done to all patients groups, and ophthalmological examination to determine the prevalence of ocular manifestations for all patient groups a...

  3. Ocular rosacea: a review Rosácea ocular: revisão

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    Ana Carolina Cabreira Vieira

    2012-10-01

    Full Text Available Rosacea is a prevalent chronic cutaneous disorder with variable presentation and severity. Although considered a skin disease, rosacea may evolve the eyes in 58-72% of the patients, causing eyelid and ocular surface inflammation. About one third of the patients develop potentially sight-threatening corneal involvement. Untreated rosacea may cause varying degrees of ocular morbidity. The importance of early diagnosis and adequate treatment cannot be overemphasized. There is not yet a diagnostic test for rosacea. The diagnosis of ocular rosacea relies on observation of clinical features, which can be challenging in up to 90% of patients in whom accompanying roseatic skin changes may be subtle or inexistent. In this review, we describe the pathophysiologic mechanisms proposed in the literature, clinical features, diagnosis and management of ocular rosacea, as well as discuss the need for a diagnostic test for the disease.A rosácea é uma condição cutânea crônica, que possui apresentações clínicas variáveis. Apesar de considerada uma doença dermatológica, os olhos podem ser acometidos em 58-72% dos casos, causando inflamação palpebral e da superfície ocular. Aproximadamente um terço dos pacientes desenvolve acometimento corneano, podendo causar baixa visual significativa. Diagnóstico precoce e tratamento adequado são de extrema importância, devido à significativa morbidade ocular que a doença pode causar. Não há, até o momento, um teste diagnóstico para rosácea. O diagnóstico da rosácea ocular depende da observação das manifestações clínicas, o que pode ser bastante desafiador em até 90% dos pacientes, em que os achados cutâneos são discretos ou inexistentes. Nesta revisão, descrevemos os mecanismos fisiopatológicos propostos na literatura, manifestações clínicas, diagnóstico e tratamento da rosácea ocular, assim como abordamos a necessidade de um teste diagnóstico.

  4. Extra-anatomic transplantations in autologous adult cell therapies aiding anatomical regeneration and physiological recovery – An insight and categorization

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    Editorial

    2015-12-01

    Full Text Available Autologous mature adult cells as well as stem cells, which are not considered pluripotent, have been reported to be safe and efficacious in clinical applications for regenerating cartilage [1] and corneal epithelium [2]. Use of primary autologous cells and stem cells expanded in number from cartilage and corneal epithelial tissues have shown abilities to reconstruct and regenerate tissues, de novo. It is to be noted that in both these cases, the source of the cells that have been used for transplantation into the cornea and cartilage have been from the same organ and tissue. The replacement cells for regeneration have also been sourced from the same germ layer, as that of the cells of the target tissue; corneal epithelial tissue embryologically originating from the ectoderm has been replaced with corneal limbal stem cells that are also of ectodermal origin from the unaffected healthy eye of the same individual. Similarly, the cartilage which developmentally is from the mesoderm has been replaced with mature chondrocytes from the non-weight bearing area of the cartilage, again of the same individual. Figure 1: Autologous, in vitro cultured, adult cell based therapies; An overview and categorization. (Click here for High Resol. Image The proceedings of the IIDIAS session published in this issue have described two novel cell therapies, where cells taken from a tissue or organ, after normal in vitro expansion, have been clinically applied to aid the regeneration of a different tissue or organ, i.e skeletal myoblasts having been used for myocardial regeneration and buccal mucosal epithelium having been used for corneal epithelial regeneration heralding the birth of a new paradigm called ‘extra-anatomic cell therapy’. The myocardium is a specialized muscle in that it works as an electrical synctitium with an intrinsic capacity to generate and propagate action potentials (involuntary as opposed to the skeletal muscles that are dependent on neuronal

  5. Potential application of ocular and cervical vestibular-evoked myogenic potentials in Meniere's disease: a review.

    Science.gov (United States)

    Young, Yi-Ho

    2013-02-01

    By stimulating the ear with air-conducted sound or bone-conducted vibration stimuli, vestibular-evoked myogenic potential (VEMP) can be recorded on the contracted neck muscles, termed cervical VEMP (cVEMP), and on the extraocular muscles, termed ocular VEMP (oVEMP). These two electrophysiological tests expand the test battery for clinicians to explore the dynamic otolithic function, adding a potential usefulness to the sacculocollic reflex and vestibulo-ocular reflex, respectively. The inner ear test battery, including audiometry, and cVEMP, oVEMP and caloric tests, is designed for complete evaluation of the inner ear function, namely, the cochlea, saccule, utricle, and semicircular canals, respectively. Using this test battery to study the localization and prevalence of hydrops formation reveals that the declining function in the cochlea, saccule, utricle, and semicircular canals mimics the declining sequence of hydrops formation in temporal bone studies. This study reviewed the physiological results in Meniere's patients via the inner ear test battery, especially the potential application of the oVEMP and cVEMP tests, to correlate with the histopathological findings of Meniere's disease. Copyright © 2012 The American Laryngological, Rhinological, and Otological Society, Inc.

  6. Albinism: Particular attention to the ocular motor system

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    Richard W Hertle

    2013-01-01

    Full Text Available The purpose of this report is to summarize an understanding of the ocular motor system in patients with albinism. Other than the association of vertical eccentric gaze null positions and asymmetric, (a periodic alternating nystagmus in a large percentage of patients, the ocular motor system in human albinism does not contain unique pathology, rather has "typical" types of infantile ocular oscillations and binocular disorders. Both the ocular motor and afferent visual system are affected to varying degrees in patients with albinism, thus, combined treatment of both systems will maximize visual function.

  7. Albinism: particular attention to the ocular motor system.

    Science.gov (United States)

    Hertle, Richard W

    2013-01-01

    The purpose of this report is to summarize an understanding of the ocular motor system in patients with albinism. Other than the association of vertical eccentric gaze null positions and asymmetric, (a) periodic alternating nystagmus in a large percentage of patients, the ocular motor system in human albinism does not contain unique pathology, rather has "typical" types of infantile ocular oscillations and binocular disorders. Both the ocular motor and afferent visual system are affected to varying degrees in patients with albinism, thus, combined treatment of both systems will maximize visual function.

  8. Further observations of ocular pathology in Down's syndrome.

    Science.gov (United States)

    Ginsberg, J; Ballard, E T; Buchino, J J; Kinkler, A K

    1980-01-01

    We studied the eyes of two children with proven trisomy 21 and updated the microscopic ocular findings. The ocular malformations, generally of a minor nature, comprise a variety of nonspecific hyperplasia or hamartomata, hypoplasias, tissue defects and heterotopias, and involve virtually every portion of the globe. Ocular and extraocular abnormalities in Down's syndrome do not correlate well embryologically, cytogenetically or in regard to incidence or severity. The type of ocular anomalies usually encountered in trisomy 21 suggests that the globe was affected by the chromosomal anomaly rather late in its development.

  9. Plasticity of the human otolith-ocular reflex

    Science.gov (United States)

    Wall, C. 3rd; Smith, T. R.; Furman, J. M.

    1992-01-01

    The eye movement response to earth vertical axis rotation in the dark, a semicircular canal stimulus, can be altered by prior exposure to combined visual-vestibular stimuli. Such plasticity of the vestibulo-ocular reflex has not been described for earth horizontal axis rotation, a dynamic otolith stimulus. Twenty normal human subjects underwent one of two types of adaptation paradigms designed either to attenuate or enhance the gain of the semicircular canal-ocular reflex prior to undergoing otolith-ocular reflex testing with horizontal axis rotation. The adaptation paradigm paired a 0.2 Hz sinusoidal rotation about a vertical axis with a 0.2 Hz optokinetic stripe pattern that was deliberately mismatched in peak velocity. Pre- and post-adaptation horizontal axis rotations were at 60 degrees/s in the dark and produced a modulation in the slow component velocity of nystagmus having a frequency of 0.17 Hz due to putative stimulation of the otolith organs. Results showed that the magnitude of this modulation component response was altered in a manner similar to the alteration in semicircular canal-ocular responses. These results suggest that physiologic alteration of the vestibulo-ocular reflex using deliberately mismatched visual and semicircular canal stimuli induces changes in both canal-ocular and otolith-ocular responses. We postulate, therefore, that central nervous system pathways responsible for controlling the gains of canal-ocular and otolith-ocular reflexes are shared.

  10. [Quantification of ocular dominance for better management of eye disease].

    Science.gov (United States)

    Chaumillon, R; Alahyane, N; Senot, P; Vergne, J; Lemoine, C; Doré-Mazars, K; Blouin, J; Vergilino-Perez, D; Guillaume, A

    2015-04-01

    The dominant eye is defined as the one we unconsciously choose when we have to perform monocular tasks. In the field of clinical neuro-ophthalmology, it is well-established that ocular dominance plays a key role in several eye diseases. Furthermore, the accurate quantification of ocular dominance is crucial with regard to certain surgical techniques. However, classical preoperative tests cannot determine the amount of ocular dominance. In order to obtain further insight into the phenomenon of ocular dominance, we study its influence at behavioral and neurophysiological levels (experiments 1 and 2). Based on these new data, we suggest a method to improve quantification of ocular dominance (experiment 3). We demonstrate that ocular dominance has an influence on hand movements and on interhemispheric transfer time. Moreover, we show that an analysis of the dynamics of saccades allows us to sort out participants with strong or weak ocular dominance. In conclusion, this better understanding of the phenomenon of ocular dominance, coupled with the analysis of saccadic dynamics, might, in the short or medium term, lead to the establishment of a quick and straightforward battery of tests allowing determination of the amount of ocular dominance for each patient. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  11. Higgs Phenomenology of Minimal Universal Extra Dimensions

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    Kakizaki Mitsuru

    2012-06-01

    Full Text Available The minimal model of Universal Extra Dimensions (MUED is briefly reviewed. We explain how the cross-sections for Higgs production via gluon fusion and decay into photons are modified, relative the the Standard Model (SM values, by KK particles running in loops, leading to an enhancement of the gg → h → γγ and gg → h → W+W− cross-sections. ATLAS and CMS searches for the SM Higgs in these channels are reinterpreted in the context of MUED and used to place new limits on the MUED parameter space. Only a small region of between 1 and 3 GeV around mh = 125 GeV for 500 GeV < R−1 < 1600 GeV remains open at the 95 % confidence level.

  12. Celulitis por cuerpo extraño

    OpenAIRE

    2016-01-01

    Las infecciones de la piel y el tejido celular subcutáneo surgen como un grupo importante de afecciones con una alta morbilidad en edades pediátricas, generalmente relacionada con traumatismo y cuerpos extraños. Se presenta el caso de una escolar femenina de 6 años de edad, con síntomas y signos clínicos que sugieren celulitis en el muslo derecho,  por su evolución tórpida se le realizó el estudio ultrasonográfico que confirmó el diagnóstico etiológico de una celulitis secundaria a un traumat...

  13. Black holes, cosmology and extra dimensions

    CERN Document Server

    Bronnikov, Kirill A

    2013-01-01

    Assuming foundational knowledge of special and general relativity, this book guides the reader on issues surrounding black holes, wormholes, cosmology, and extra dimensions. Its first part is devoted to local strong field configurations (black holes and wormholes) in general relativity and the most relevant of alternative theories: scalar-tensor, f(R) and multidimensional theories. The second part is on cosmology, including inflation and a unified description of the whole evolution of the universe. The third part concerns multidimensional theories of gravity and contains a number of original results obtained by the authors. Expository work is conducted for a mechanism of symmetries and fundamental constants formation, while the original approach to nonlinear multidimensional gravity that is able to construct a unique perspective describing different phenomena is highlighted. Much of the content is new in book publications, because it was previously found only in journal publications, e.g. regarding regular bl...

  14. Phenomenology of symmetry breaking from extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Alfaro, Jorge [Facultad de Fisica, Pontificia Universidad Catolica de Chile, Casilla 306, Santiago 22 (Chile); Broncano, Alicia [Max Planck Institute for Physics, Foehringer Ring 6, 80805 Munich (Germany); Belen Gavela, Maria [Departamento de Fisica Teorica and Instituto de Fisica Teorica, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Rigolin, Stefano [Departamento de Fisica Teorica and Instituto de Fisica Teorica, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain); Salvatori, Matteo [Departamento de Fisica Teorica and Instituto de Fisica Teorica, Universidad Autonoma de Madrid, Cantoblanco, E-28049 Madrid (Spain)

    2007-01-15

    Motivated by the electroweak hierarchy problem, we consider theories with two extra dimensions in which the four-dimensional scalar fields are components of gauge boson in full space. We explore the Nielsen-Olesen instability for SU(N) on a torus, in the presence of a magnetic background. A field theory approach is developed, computing explicitly the minimum of the complete effective potential, including tri-linear and quartic couplings and determining the symmetries of the stable vacua. We also develop appropriate gauge-fixing terms when both Kaluza-Klein and Landau levels are present and interacting, discussing the interplay between the possible six and four dimensional choices. The equivalence between coordinate dependent and constant Scherk-Schwarz boundary conditions - associated to either continuous or discrete Wilson lines - is analyzed.

  15. Ocular rigidity, outflow facility, ocular pulse amplitude, and pulsatile ocular blood flow in open-angle glaucoma: a manometric study.

    Science.gov (United States)

    Dastiridou, Anna I; Tsironi, Evangelia E; Tsilimbaris, Miltiadis K; Ginis, Harilaos; Karyotakis, Nikos; Cholevas, Pierros; Androudi, Sofia; Pallikaris, Ioannis G

    2013-07-10

    To compare ocular rigidity (OR) and outflow facility (C) coefficients in medically treated open-angle glaucoma (OAG) patients and controls, and to investigate differences in ocular pulse amplitude (OPA) and pulsatile ocular blood flow (POBF) between the two groups. Twenty-one OAG patients and 21 controls undergoing cataract surgery were enrolled. Patients with early or moderate primary or pseudoexfoliative OAG participated in the glaucoma group. A computer-controlled system, consisting of a pressure transducer and a microstepping device was employed intraoperatively. After cannulation of the anterior chamber, IOP was increased by infusing the eye with microvolumes of saline solution. IOP was recorded after each infusion step. At an IOP of 40 mm Hg, an IOP decay curve was recorded for 4 minutes. OR coefficients, C, OPA, and POBF were estimated from IOP and volume recordings. There were no differences in age or axial length in the two groups. The OR coefficient was 0.0220 ± 0.0053 μl(-1) in the OAG and 0.0222 ± 0.0039 μl(-1) in the control group (P = 0.868). C was 0.092 ± 0.082 μL/min/mm Hg in the glaucoma group compared with 0.149 ± 0.085 μL/min/mm Hg in the control group at an IOP of 35 mm Hg (P 0.05). Manometric data reveal lower C in OAG patients and increased C with increasing IOP. There were no differences in the OR coefficient, OPA, and POBF between medically treated OAG patients and controls, failing to provide evidence of altered scleral distensibility and choroidal blood flow in OAG.

  16. Dynamic Extra Buses Scheduling Strategy in Public Transport

    Directory of Open Access Journals (Sweden)

    Bin Yu

    2015-06-01

    Full Text Available This paper presents a dynamic extra buses scheduling strategy to improve the transit service of transit routes. In this strategy, in order to decide when to dispatch an extra bus, the service reliability of transit route is assessed firstly. A model aimed at maximizing the benefit of the extra buses scheduling strategy is constructed to determine how many stops extra buses need to skip from the terminal to accommodate passengers at the following stops. A heuristic algorithm is defined and implemented to estimate the service reliability of transit route and to optimize the initial stop of extra buses scheduling strategy. Finally, the strategy is tested on two examples: a simple and a real-life transit route in the Dalian city in China. The results show that the extra buses scheduling strategy based on terminal stops with a reasonable threshold can save 8.01% waiting time of passengers.

  17. Profound retinal ischaemia after ranibizumab administration in an eye with ocular ischaemic syndrome

    DEFF Research Database (Denmark)

    Kofoed, Peter Kristian; Munch, Inger Christine; Larsen, Michael

    2009-01-01

    Abstract. Purpose: To report the result of ranibizumab administration in an eye with ocular ischaemic syndrome. Methods: Fluorescein angiography, ocular pneumoplethysmography and retinal vessel calibre measurement. Results: An 85-year-old man with ocular ischaemic syndrome demonstrated vision loss...

  18. Cosmologically safe QCD axion as a present from extra dimension

    Directory of Open Access Journals (Sweden)

    Masahiro Kawasaki

    2015-11-01

    Full Text Available We propose a QCD axion model where the origin of PQ symmetry and suppression of axion isocurvature perturbations are explained by introducing an extra dimension. Each extra quark–antiquark pair lives on branes separately to suppress PQ breaking operators. The size of the extra dimension changes after inflation due to an interaction between inflaton and a bulk scalar field, which implies that the PQ symmetry can be drastically broken during inflation to suppress undesirable axion isocurvature fluctuations.

  19. Cosmologically safe QCD axion as a present from extra dimension

    Energy Technology Data Exchange (ETDEWEB)

    Kawasaki, Masahiro [Institute for Cosmic Ray Research, The University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Yamada, Masaki, E-mail: yamadam@icrr.u-tokyo.ac.jp [Institute for Cosmic Ray Research, The University of Tokyo, Kashiwa, Chiba 277-8582 (Japan); Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan); Yanagida, Tsutomu T. [Kavli IPMU (WPI), UTIAS, The University of Tokyo, Kashiwa, Chiba 277-8583 (Japan)

    2015-11-12

    We propose a QCD axion model where the origin of PQ symmetry and suppression of axion isocurvature perturbations are explained by introducing an extra dimension. Each extra quark–antiquark pair lives on branes separately to suppress PQ breaking operators. The size of the extra dimension changes after inflation due to an interaction between inflaton and a bulk scalar field, which implies that the PQ symmetry can be drastically broken during inflation to suppress undesirable axion isocurvature fluctuations.

  20. Compact extra dimensions in cosmologies with f(T) structure

    CERN Document Server

    Fiorini, Franco; Vasquez, Yerko

    2013-01-01

    The presence of compact extra dimensions in cosmological scenarios in the context of f(T)-like gravities is discussed. For the case of toroidal compactifications, the analysis is performed in an arbitrary number of extra dimensions. Spherical topologies for the extra dimensions are then carefully studied in six and seven spacetime dimensions, where the proper vielbein fields responsible for the parallelization process are found.

  1. Mudanças oculares durante a gestação Ocular changes during pregnancy

    Directory of Open Access Journals (Sweden)

    Enéias Bezerra Gouveia

    2009-04-01

    Full Text Available A gestação pode causar várias alterações no funcionamento do olho humano, tanto nas condições sistêmicas quanto em doenças oculares, sendo seus efeitos divididos em três categorias: alterações fisiológicas, mudanças em doenças oculares pré-existentes e alterações patológicas. O presente texto propõe uma revisão bibliográfica sobre o tema. Os autores pesquisaram os bancos de dados do PubMed (MEDLINE e LILACS.Pregnancy can cause several alterations in human eye function in healthy condition as well in ocular disease; these effects on the eyes are divided into three categories: physiologic alterations, ocular diseases changes already existing before the pregnancy, and pathological alterations. The present text proposes a bibliographical revision on the theme. The authors researched PubMed (MEDLINE and LILACS databases.

  2. Serological IgG avidity test for ocular toxoplasmosis

    Directory of Open Access Journals (Sweden)

    Suresh S

    2012-01-01

    Full Text Available Subramaniam Suresh1, Saidin Nor-Masniwati1, Muhd Nor Nor-Idahriani1, Wan-Hitam Wan-Hazabbah1, Mohamed Zeehaida2, Embong Zunaina11Department of Ophthalmology, 2Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, MalaysiaBackground: The purpose of this study was to evaluate the immunoglobulin (Ig G avidity of serological toxoplasmosis testing in patients with ocular inflammation and to determine the clinical manifestations of ocular toxoplasmosis.Methods: A retrospective review of all patients presenting with ocular inflammation to the Hospital Universiti Sains Malaysia, Kelantan, Malaysia between 2005 and 2009 was undertaken. Visual acuity, clinical manifestations at presentation, toxoplasmosis antibody testing, and treatment records were analyzed.Results: A total of 130 patients with ocular inflammation were reviewed retrospectively. The patients had a mean age of 38.41 (standard deviation 19.24, range 6–83 years. Seventy-one patients (54.6% were found to be seropositive, of whom five (3.8% were both IgG and IgM positive (suggestive of recently acquired ocular toxoplasmosis while one (0.8% showed IgG avidity ≤40% (suggestive of recently acquired ocular toxoplasmosis and 65 patients (50.0% showed IgG avidity >40% (suggestive of reactivation of toxoplasmosis infection. Chorioretinal scarring as an ocular manifestation was significantly more common in patients with seropositive toxoplasmosis (P = 0.036. Eighteen patients (13.8% were diagnosed as having recent and/or active ocular toxoplasmosis based on clinical manifestations and serological testing.Conclusion: Ocular toxoplasmosis is a clinical diagnosis, but specific toxoplasmosis antibody testing helps to support the diagnosis and to differentiate between reactivation of infection and recently acquired ocular toxoplasmosis.Keywords: ocular toxoplasmosis, chorioretinal scar, toxoplasmosis antibody, IgG avidity test

  3. Science with the EXTraS Project: Exploring the X-ray Transient and variable Sky

    CERN Document Server

    De Luca, A; Tiengo, A; D'Agostino, D; Watson, M G; Haberl, F

    2015-01-01

    The EXTraS project (Exploring the X-ray Transient and variable Sky) will characterise the temporal behaviour of the largest ever sample of objects in the soft X-ray range (0.1-12 keV) with a complex, systematic and consistent analysis of all data collected by the European Photon Imaging Camera (EPIC) instrument onboard the ESA XMM-Newton X-ray observatory since its launch. We will search for, and characterize variability (both periodic and aperiodic) in hundreds of thousands of sources spanning more than nine orders of magnitude in time scale and six orders of magnitude in flux. We will also search for fast transients, missed by standard image analysis. Our analysis will be completed by multiwavelength characterization of new discoveries and phenomenological classification of variable sources. All results and products will be made available to the community in a public archive, serving as a reference for a broad range of astrophysical investigations.

  4. Buccal Epithelium in treating Ocular Surface Disorders

    Directory of Open Access Journals (Sweden)

    Srinivas KR

    2008-11-01

    Full Text Available Background - Ocular surface disorders due to limbal stem cell deficiency are an important cause of ocular morbidity and visual loss. Although autologous limbal stem cell transplants have helped in the management of unilateral disease, allografts in those with bilateral disease often fail due to immunological reasons. The use of autologous buccal epithelium cultivated on amniotic membrane has been described as a useful approach in the management of this condition. It is the purpose of this study to explore the feasibility of using a novel thermo-gelatin polymer (TGP as a substrate to culture these cells, and to characterize them using RNA extraction and RT-PCR. Methods - Oral cheek mucosal biopsies were obtained from 5 adult patients undergoing Modified Osteo-Odonto Keratoprosthesis surgery. The specimens were transported to the laboratory in transport medium. The cells were released using enzymatic digestion and seeded in both convention culture medium and TGP. The resulting cellular growth was characterized using RNA extraction and RT-PCR. Results - Cells could be cultured from 4 of the 5 specimens. In one specimen, contamination occurred and this was discarded. In the other specimens, the cheek epithelial cells could be cultured in both the conventional culture medium and TGP, with equal ease. RT-PCR revealed the presence of K3, a marker for epithelial cells, and GAPDH indicating the presence of some adipose tissue as well. Conclusions - It is possible to culture autologous cheek mucosal epithelial cells using TGP, a synthetic scaffold, without the need for other biological substrates. Since the specimens are obtained from the oral cavity, stringent asepsis is required. Further studies are required for histopathological characterization of the cultured cells and to create a model for delivery onto the ocular surface of eyes with bilateral surface disease due to limbal stem cell deficiency.

  5. Persian Traditional Medicine and Ocular Health

    Science.gov (United States)

    Namdar, Hasan; Emaratkar, Elham; Hadavand, Mohammad Bagher

    2015-01-01

    The Persian Traditional Medicine (PTM) system pays special attention to disease prevention. In PTM, physicians believe that overeating may cause accumulation of unhealthy substances in the body and diseases called “Emtela.” With respect to ocular health, foods can be categorized as beneficial and harmful. Harmful foods such as beef, geese, eggplant, cauliflower, and cheese can cause reduced vision. Dehydrating foods such as walnut and salty fish and hot foods such as garlic, onion, and pepper can cause dry eye. Food items that have beneficial effects on ocular health include thyme and saffron and fruits such as grape, fig, apple, plum, and berries. PTM stipulates that one should not drink water with meals or immediately afterwards, since drinking cold (icy) water causes difficulty in absorption of nutrients. Gulping water may have harmful effects on the eyes; therefore, PTM physicians recommend drinking water at a suitable temperature. It is not safe to drink water first at the morning. Sleeping right after eating is harmful too. Avicenna believes that sleeping on one’s belly after a full meal is very harmful for the eyes. Galen says that old people need deep and continuous sleep more than others. From the view of PTM, moving eyes in different directions, making delicate expressions, trying to look at delicate and find pictures and reading small letters would remove ocular fatigue. There have been mentions of local medicine for improving vision as well; for instance, fennel extracts, pomegranate juice, and honey which are suitable for vision improvement. Local administration of pomegranate blossoms is suitable for treating inflammatory reactions. PMID:27800504

  6. Silk film biomaterials for ocular surface repair

    Science.gov (United States)

    Lawrence, Brian David

    Current biomaterial approaches for repairing the cornea's ocular surface upon injury are partially effective due to inherent material limitations. As a result there is a need to expand the biomaterial options available for use in the eye, which in turn will help to expand new clinical innovations and technology development. The studies illustrated here are a collection of work to further characterize silk film biomaterials for use on the ocular surface. Silk films were produced from regenerated fibroin protein solution derived from the Bombyx mori silkworm cocoon. Methods of silk film processing and production were developed to produce consistent biomaterials for in vitro and in vivo evaluation. A wide range of experiments was undertaken that spanned from in vitro silk film material characterization to in vivo evaluation. It was found that a variety of silk film properties could be controlled through a water-annealing process. Silk films were then generated that could be use in vitro to produce stratified corneal epithelial cell sheets comparable to tissue grown on the clinical standard substrate of amniotic membrane. This understanding was translated to produce a silk film design that enhanced corneal healing in vivo on a rabbit injury model. Further work produced silk films with varying surface topographies that were used as a simplified analog to the corneal basement membrane surface in vitro. These studies demonstrated that silk film surface topography is capable of directing corneal epithelial cell attachment, growth, and migration response. Most notably epithelial tissue development was controllably directed by the presence of the silk surface topography through increasing cell sheet migration efficiency at the individual cellular level. Taken together, the presented findings represent a comprehensive characterization of silk film biomaterials for use in ocular surface reconstruction, and indicate their utility as a potential material choice in the

  7. Ocular findings in patients with systemic sclerosis

    Directory of Open Access Journals (Sweden)

    Beatriz de A. F Gomes

    2011-01-01

    Full Text Available OBJECTIVE: To evaluate the frequency and characteristics of ocular manifestations in outpatients with systemic sclerosis. METHODS: In this cross-sectional study, 45 patients with systemic sclerosis were enrolled. Data regarding demographics, disease duration and subtype, age at diagnosis, nailfold capillaroscopic pattern and autoantibody profile were collected, and a full ophthalmic examination was conducted. Parametric (Student's t-test and nonparametric (Mann-Whitney U test tests were used to compare continuous variables. Fisher's exact test was used to compare categorical data. P values < 0.05 were considered significant. RESULTS: Twenty-three subjects (51.1% had eyelid skin changes; 22 (48.9% had keratoconjunctivitis sicca, 19 (42.2% had cataracts, 13 (28.9% had retinal microvascular abnormalities and 6 (13.3% had glaucoma. Eyelid skin changes were more frequent in patients with the diffuse subtype of systemic sclerosis and were associated with a younger age and an earlier age at diagnosis. Cataracts were presumed to be age-related and secondary to corticosteroid treatment. There was no association between demographic, clinical or serological data and keratoconjunctivitis sicca. The retinal microvascular abnormalities were indistinguishable from those related to systemic hypertension and were associated with an older age and a severe capillaroscopic pattern. CONCLUSIONS: Eyelid skin abnormalities and keratoconjunctivitis sicca were the most common ocular findings related to systemic sclerosis. Some demographic and clinical data were associated with some ophthalmic features and not with others, showing that the ocular manifestations of systemic sclerosis are characterized by heterogeneity and reflect the differences in the implicated pathophysiological mechanisms.

  8. 360-degree retinectomy for severe ocular rupture

    Institute of Scientific and Technical Information of China (English)

    ZHANG Mao-nian; JIANG Cai-hui

    2005-01-01

    Objective: To investigate the effect of 360-degree retinectomy for severe ocular rupture and evaluate the related factors associated with prognosis.Methods: A retrospective analysis was performed on 28 consecutive patients, 18 men and 10 women, with severe ocular rupture admitted to the Chinese PLA General Hospital between January 1999 and January 2002. The patients' ages ranged from 16 to 58 years, mean 29.5years. All operations were performed by the first author.All patients underwent standard 3-port pars plana vitrectomy with scleral encircling buckle,endophotocoagulation, and tamponaded with silicone oil.Lensectomy were performed on 15 eyes. 360-degree retinotomy and retinectomy were performed at anterior equator on 16 eyes, and posterior equator on 12 eyes.Results: During operation, all patients were confirmed to have vitreous hemorrhage and retinal detachment, in which hemorrhagic ciliary body detachment was found in 9 eyes, suprachoroidal hemorrhage in 12 eyes,retinal twisting like flower stalk in 11 eyes, and retinal incarceration in 17 eyes. Postoperative follow-up was conducted in 26 cases, ranged from 6 months to 46 months.Retinal reattachment achieved in 20 eyes (76. 9%), in which three patients' retina was reattached after revitrectomy. The silicone oil was removed at the fourth month in 8 eyes postoperatively. Corrected visual acuity of 0.02 or more was in 14 eyes (70. 0%) among the 20patients with reattached retina. Visual acuity of 0.05 or more was in 7 eyes ( 35.0 % ), and 0.1 or more was in 3eyes. The best visual acuity was 0.3 in 1 eye.Conclusions: Retinectomy may improve the prognosis of severe ocular rupture and save the visual function of some patients.

  9. The prevalence of ocular surface complaints in Brazilian patients with glaucoma or ocular hypertension

    Directory of Open Access Journals (Sweden)

    Vital Paulino Costa

    2013-08-01

    Full Text Available PURPOSE: To examine the prevalence of ocular surface complaints in Brazilian patients with glaucoma or ocular hypertension who used topical intraocular pressure (IOP-lowering regimens. METHODS: In this multicenter, noninterventional, single-visit study, adults with glaucoma or ocular hypertension treated with an IOP-lowering regimen were administered the 12-item ocular surface disease index (OSDI questionnaire. Each response was scored on a 5-point scale, with 0 indicating symptom present none of the time and 4 indicating symptom present all of the time. The average of the 12 item responses for each patient was transformed to a scale from 0 to 100, with higher scores representing worse disabilities. OSDI results then were categorized as absence of OSD (scores of 0-12, mild OSD (scores of 13-22, moderate OSD (scores of 23-32, or severe OSD (scores of 33100. RESULTS: The 173 enrolled patients had a mean age of 61.2 years, were women in 65.3% of cases, and had glaucoma in 89.0% of cases and ocular hypertension in 11.0% of cases. OSDI scores for 158 patients using 1 IOP-lowering therapy indicated no OSD in 37.3% of patients (59/158, mild OSD in 20.9% (33/158, moderate OSD in 17.1% (27/158, and severe OSD in 24.7% (39/158. For the 120 patients using 1 IOP-lowering medication and having a known duration of diagnosis of glaucoma or ocular hypertension, mean OSDI scores were numerically higher (worse for the 39 patients with a diagnosis ≥6 years long (score 25 [± 20], indicating moderate OSD than for the 81 patients with a diagnosis lasting <6 years (score 22 [± 20], indicating mild OSD; however, no significant differences in OSDI scores by duration of diagnosis were evident in means (P=0.49, distributions (P≥0.26, or correlation (P=0.77. CONCLUSIONS: A large proportion of Brazilian patients treated with 1 IOP-lowering therapy had some ocular surface complaints.

  10. Alterações oculares induzidas pela quimioterapia Ocular changes induced by chemotherapy

    Directory of Open Access Journals (Sweden)

    Alessandra Pinheiro Chaves

    2007-08-01

    Full Text Available As drogas antineoplásicas proporcionam aumento da sobrevida dos portadores de neoplasias, mas podem induzir efeitos adversos em vários órgãos e tecidos. A mucosite é efeito adverso freqüentemente observado durante a administração de certos quimioterápicos. A toxicidade ocular dessas drogas pode se manifestar por alterações da superfície ocular e do filme lacrimal. O objetivo foi avaliar alterações da superfície ocular induzidas pelos quimioterápicos e estabelecer sua correlação clínica com mucosite e quimioterapia. Trinta e nove pacientes foram submetidos a exame oftalmológico completo, citologia de impressão e estudo microbiológico da conjuntiva. Comparamos 2 grupos: com manifestação de mucosite (caso e sem manifestação de mucosite (controle. Para análise estatística, utilizamos o software Statistical Package for Social Sciences. A mucosite foi identificada em 51,4% dos pacientes avaliados após a quimioterapia. O tempo de quebra do filme lacrimal mostrou redução significativa após a quimioterapia (pAntineoplastic agents offer an increase in the patients' survival rates, but may induce side effects in different organs and tissues. Mucositis is one of the most common side effects during chemotherapy with certain agents. The ocular toxicity induced by these drugs may manifest as changes in the ocular surface and in the tear film. The purpose of this research was to study the ocular surface changes induced by chemotherapy and to establish their clinical correlation with the chemotherapy and mucositis. The 39 selected patients underwent a full ophthalmological examination and supplementary tests. We compared 2 groups of patients: with (case and without mucositis (control. Statistical analysis was performed with the Statistical Package for Social Sciences software. Mucositis was identified in 51.4% of the patients after chemotherapy. The brakeup time showed a statistically significant decrease after chemotherapy (p<0

  11. Sources of variance in ocular microtremor.

    Science.gov (United States)

    Sheahan, N F; Coakley, D; Bolger, C; O'Neill, D; Fry, G; Phillips, J; Malone, J F

    1994-02-01

    This study presents a preliminary investigation of the sources of variance in the measurement of ocular microtremor frequency in a normal population. When the results from both experienced and relatively inexperienced operators are pooled, factors that contribute significantly to the total variance include the measurement procedure (p < 0.001), day-to-day variations within subjects (p < 0.001), and inter-subject differences (p < 0.01). Operator experience plays a role in determining the measurement precision: the intra-subject coefficient of variation is about 5% for a very experienced operator, and about 14% for a relatively inexperienced operator.

  12. Ocular cells and light: harmony or conflict?

    Science.gov (United States)

    Jurja, Sanda; Hîncu, Mihaela; Dobrescu, Mihaela Amelia; Golu, Andreea Elena; Bălăşoiu, Andrei Theodor; Coman, Mălina

    2014-01-01

    Vision is based on the sensitivity of the eye to visible rays of the solar spectrum, which allows the recording and transfer of visual information by photoelectric reaction. Any electromagnetic radiation, if sufficiently intense, may cause damages in living tissues. In a changing environment, the aim of this paper is to point out the impact of light radiation on ocular cells, with its phototoxicity potential on eye tissues. In fact, faced with light and oxygen, the eye behaves like an ephemeral aggregate of unstable molecules, like a temporary crystallization threatened with entropia.

  13. Oculomotricidade e seus fundamentos Ocular motility: foundations

    OpenAIRE

    Harley E. A. Bicas

    2003-01-01

    Partindo-se de um circuito esquemático relacionando os sistemas sensorial (visual binocular) e oculomotor, cujos defeitos em vias aferentes ou eferentes, ou de suas interações, explicam o aparecimento dos estrabismos e suas conseqüências, são examinados os fundamentos e referenciais da movimentação ocular. Apresentam-se os conceitos de eixos e planos, centro de massa e de rotação, definem-se os movimentos monoculares de translação e de rotação e os binoculares de versões e vergências. É també...

  14. An unusual ocular emergency in severe dengue

    Directory of Open Access Journals (Sweden)

    Kalpana Badami Nagaraj

    2014-01-01

    Full Text Available Dengue, one of the most common mosquito-borne flavivirus diseases affecting humans, is spread by the Aedes aegypti mosquito. Most people infected with dengue virus are asymptomatic or only have mild symptoms such as an uncomplicated fever; few have more severe features, while in a small proportion it is life-threatening. Severe dengue is defined as that associated with severe bleeding, severe organ dysfunction, or severe plasma leakage. Ophthalmic manifestations can involve both the anterior and posterior segment. We report an ocular emergency of proptosis and globe rupture in a patient with severe dengue.

  15. Fabrication of a custom ocular prosthesis

    Directory of Open Access Journals (Sweden)

    Tania Sethi

    2014-01-01

    Full Text Available Defects of the eye may follow removal of a part of or the entire orbit. This results in the patient becoming visually, esthetically and psychologically handicapped. Restoring the defect with a silicone- or acrylic-based prosthesis not only restores esthetics but also gives back the lost confidence to the patient. This is a case report of a patient with a `pthisical eye` and details the steps in fabrication of an ocular prosthesis. Particular attention has been given to the laboratory process in this technique to minimize the residual monomer content in the artificial eye.

  16. Microbiota conjuntival em pacientes com alergia ocular

    OpenAIRE

    Alexandre Mattoso Libório; Maria Cristina Nishiwaki-Dantas; Lycia Mara Jenne Mimica; Paulo Elias Correa Dantas; Ana Luísa Höfling de Lima

    2005-01-01

    OBJETIVO: Avaliar a presença de microbiota aeróbia da conjuntiva de portadores de alergia ocular e comparar a um grupo controle. MÉTODOS: Foram examinados 133 pacientes no período de abril a junho de 2001 divididos em 2 grupos. O grupo A foi composto de 63 portadores de conjuntivite alérgica (sem uso de medicação) e o grupo B de 70 pacientes do ambulatório geral (controle). Foram coletadas amostras do fundo de saco conjuntival do olho direito de todos os pacientes e o material foi semeado em ...

  17. [Contusive ocular trauma--case report].

    Science.gov (United States)

    Muşat, O; Coman, Corina; Cristescu, R; Asandi, R

    2012-01-01

    We present the case of a 48 year old man who was admitted for the decreased visual acuity of the left eye for about 20 years, when a left sided facial trauma had occured. Clinical examination and lab exams revealed the cause of this change: ocular contusive posttraumatic status for about 20 years (anamnestic), iridodialysis, corectopie, traumatic cataract, PVR, tractional retinal detachment. Surgical treatment was warranted. We performed cataract extraction, posterior vitrectomy with laser fotocoagulation and injection of silicon oil 1000. We followed the pacient's post-operative evolution and we extracted of the silicone oil six months later. The evolution was favorable.

  18. Curvature sensor for ocular wavefront measurement.

    Science.gov (United States)

    Díaz-Doutón, Fernando; Pujol, Jaume; Arjona, Montserrat; Luque, Sergio O

    2006-08-01

    We describe a new wavefront sensor for ocular aberration determination, based on the curvature sensing principle, which adapts the classical system used in astronomy for the living eye's measurements. The actual experimental setup is presented and designed following a process guided by computer simulations to adjust the design parameters for optimal performance. We present results for artificial and real young eyes, compared with the Hartmann-Shack estimations. Both methods show a similar performance for these cases. This system will allow for the measurement of higher order aberrations than the currently used wavefront sensors in situations in which they are supposed to be significant, such as postsurgery eyes.

  19. Extra relativistic degrees of freedom without extra particles using Planck data

    CERN Document Server

    Mastache, Jorge

    2013-01-01

    A recent number of analysis of cosmological data have shown indications for the presence of extra radiation beyond the standard model at equality and nucleosynthesis epoch, which has been usually interpreted as an effective number of neutrinos, Neff > 3.046. In this work we establish the theoretical basis for a particle physics-motivated model (Bound Dark Matter, BDM) which explain the need of extra radiation. The BDM model describes dark matter particles which are relativistic at a scale below aac due to non-perturbative methods, as protons and neutrons do, this process is described by a time dependent equation of state, w_bdm(a). We compute the range of values of the BDM model, xc=ac*vc, that explain the values obtain for the 4He at BBN and Neff at equality. Combining different analysis we conclude that this may happen in xc = 5.01 (^{+6.01}_{-5.01}) x 10^{-5} with a vc = 0.56 \\pm 0.39. We conclude that we can account for the apparent extra radiation Nex using phase transition in the dark matter with a time...

  20. Clinical application of ocular trauma score for mechanical ocular injury in armed forces

    Directory of Open Access Journals (Sweden)

    Ying ZHANG

    2011-10-01

    Full Text Available Objective To evaluate the predictive value of ocular trauma score(OTS in mechanical ocular injuries occurring in military forces,and compare the difference of OTS application between ocular injury caused by military training and non-military training.Methods The data of 633 inpatients from armed forces suffering from injury of 665 eyes were retrospectively reviewed.Of the 665 injured eyes,326 were injured during military training and 339 during non-military training.The likelihood of final visual acuity(VA calculated with the OTS score was compared with that by the present OTS study,and the correlation between the score and final VA was then analyzed.Results Compared with the distribution of final VA in standard OTS score,the ratio in category 1 was statistically different in present study(P 0.05.There were significant differences in ratio of category 3 between eyes injured by military and non-military training(P < 0.05,and both ratios in category 1 were significantly different compared with those in standard OTS(P < 0.01,e.g.the ratio of NLP was lower(50% vs 73%,P < 0.01;43% vs 73%,P < 0.01;and the ratio in category 2 was significantly different between the eyes injured by non-military training and standard OTS(P < 0.05.However,the OTS showed positive correlation with final VA in present study(P < 0.0001.Conclusion OTS calculated at initial examination may primarily provide a piece of prognostic information of mechanical ocular injuries,and is of special benefit for deciding a prompt management or for evacuation decision for severe ocular injuries caused by military training.

  1. Black Sun: Ocular Invisibility of Relativistic Luminous Astrophysical Bodies

    CERN Document Server

    Lee, Jeffrey S

    2015-01-01

    The relativistic Doppler shifting of visible electromagnetic radiation to beyond the human ocular range reduces the incident radiance of the source. Consequently, luminous astrophysical bodies (LABs) can be rendered invisible with sufficient relativistic motion. This paper determines the proper distance as a function of relativistic velocity at which a luminous object attains ocular invisibility.

  2. Experimental Models of Ocular Infection with Toxoplasma Gondii

    Science.gov (United States)

    Dukaczewska, Agata; Tedesco, Roberto; Liesenfeld, Oliver

    2015-01-01

    Ocular toxoplasmosis is a vision-threatening disease and the major cause of posterior uveitis worldwide. In spite of the continuing global burden of ocular toxoplasmosis, many critical aspects of disease including the therapeutic approach to ocular toxoplasmosis are still under debate. To assist in addressing many aspects of the disease, numerous experimental models of ocular toxoplasmosis have been established. In this article, we present an overview on in vitro, ex vivo, and in vivo models of ocular toxoplasmosis available to date. Experimental studies on ocular toxoplasmosis have recently focused on mice. However, the majority of murine models established so far are based on intraperitoneal and intraocular infection with Toxoplasma gondii. We therefore also present results obtained in an in vivo model using peroral infection of C57BL/6 and NMRI mice that reflects the natural route of infection and mimics the disease course in humans. While advances have been made in ex vivo model systems or larger animals to investigate specific aspects of ocular toxoplasmosis, laboratory mice continue to be the experimental model of choice for the investigation of ocular toxoplasmosis. PMID:26716018

  3. Ocular toxicity of benzalkonium chloride homologs compared with their mixtures.

    Science.gov (United States)

    Okahara, Akihiko; Tanioka, Hidetoshi; Takada, Koichi; Kawazu, Kouichi

    2013-12-01

    This study was performed to assess the in vivo ocular toxicity of benzalkonium chloride (BAK) homologs compared with commercially available BAK (BAK mixture) and to assess the ocular toxicity of BAK homolog after repeated ocular application. Rabbit eyes were examined by ophthalmology and scanning electron microscopy (SEM) after 10 applications of BAK homologs with C12 (C12-BAK) and C14 (C14-BAK) alkyl chain lengths and a BAK mixture at concentrations of 0.001% (w/v), 0.003% (w/v), 0.005% (w/v), 0.01% (w/v) and 0.03% (w/v). The ocular toxicity of C12-BAK to rabbit eyes was examined by ophthalmology and histopathology after repeated ocular application for 39 weeks. In addition, the antimicrobial activities of C12-BAK and C14-BAK against A. niger, S. aureus and P. aeruginosa were assessed. Ocular toxicity of C12-BAK was less than those of the BAK mixture and C14-BAK. No ocular toxicity was noted after ocular application of 0.01% C12-BAK to rabbits for 39 weeks. C12-BAK showed antimicrobial activities at a concentration of 0.003%. These results suggest that the use of C12-BAK to replace BAK mixture as a preservative in ophthalmic solutions should be considered in order to reduce the incidence of the corneal epithelial cell injury induced clinically by BAK.

  4. Implementing and applying the Ocular Trauma Score: the challenges

    Directory of Open Access Journals (Sweden)

    Desirée C Murray

    2016-01-01

    Full Text Available Ocular trauma is a significant cause of unilateral blindness in the Caribbean in both adults and children. In Trinidad and Tobago, blunt ocular injury will typically account for around a third of all referrals from the Accident and Emergency department to the ophthalmology unit.

  5. Epidemiology, Pathophysiology, and the Future of Ocular Toxoplasmosis

    NARCIS (Netherlands)

    Kijlstra, A.; Pedersen, E.

    2014-01-01

    Despite large advances in the field of ocular toxoplasmosis, large gaps still exist in our knowledge concerning the epidemiology and pathophysiology of this potentially blinding infectious disease. Although ocular toxoplasmosis is considered to have a high health burden, still little is known about

  6. Effect of sleep related breathing disorders on ocular function

    Directory of Open Access Journals (Sweden)

    Enas Elsayed Mohamed

    2014-07-01

    In conclusion: The increased prevalence of ocular symptoms and signs in patients with OSAHS indicates a need to increase awareness and establish close collaboration with the sleep physicians with clear pathways for review of OSAHS patients by the ophthalmic services. We should study the effect of treatment of OSAHS on the ocular manifestations.

  7. Characterization of the normal microbiota of the ocular surface.

    Science.gov (United States)

    Willcox, Mark D P

    2013-12-01

    The ocular surface is continually exposed to the environment and as a consequence to different types of microbes, but whether there is a normal microbiota of the ocular surface remains unresolved. Using traditional microbial culture techniques has shown that microbiota, or whether the microbiota are only transiently present. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Nature and frequency of respiratory involvement in chronic progressive external ophthalmoplegia

    NARCIS (Netherlands)

    Smits, B.W.; Heijdra, Y.F.; Cuppen, F.; Engelen, B.G. van

    2011-01-01

    Chronic progressive external ophthalmoplegia (CPEO) is a relatively common mitochondrial disorder. Weakness of the extra-ocular, limb girdle and laryngeal muscles are established clinical features. Respiratory muscle involvement however has never been studied systematically, even though respiratory

  9. Distrofia oftalmoplégica progressiva. Forma de inicio ocular precoce e comprometimento muscular universal tardio Progressive ophthalmoplegic dystrophy

    Directory of Open Access Journals (Sweden)

    João P. Rodrigues

    1968-03-01

    Full Text Available É estudada uma forma particular de distrofia muscular progressiva — forma óculo-faríngea — cujo diagnóstico foi comprovado mediante traçados eletromiográficos e biópsia do músculo orbicular da pálpebra. São analisadas as duas formas de distrofias oftalmoplégicas: 1 miopatia ocular; 2 miopatia óculo-faríngea. A forma óculo-faríngea é mais rara, incide em idades mais avançadas (média de 40 anos em comparação com a forma ocular pura (média de 23 anos; além disso, é ressaltada a alta incidência familiar daquela forma de miopatia. O caso ora registrado parece ser um élo entre as duas formas, pois o início foi precoce, sem incidência familiar e com comprometimento da deglutição e de músculos da face, pescoço, tronco, cintura escapular, pélvica e dos membros.A case of peculiar form of progressive muscular dystrophy — the oculopharyngeal one — is reported. The diagnosis was ascertained by electromiography and biopsy of orbicularis palpebrae muscle. Two forms of ophthalmoplegic dystrophy are analysed: 1 ocular myopathy and 2 oculopharyngeal miopathy. The latter is less frequent, occurring on patients in the fourth decade, in comparison with the pure ocular form affecting patients in the second decade. Besides this, the high familial incidence of the oculo-pharyngeal form is stressed. The reported case seems to be an intermediate form between them. The onset occurred at 11 years of age; there was no other case in the family, the disease involving swallowing, face, neck, trunk, shoulder, pelvic and members muscles.

  10. Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia

    DEFF Research Database (Denmark)

    Green, Charlotte J; Henriksen, Tora I; Pedersen, Bente K;

    2012-01-01

    Glucagon like peptide-1 (GLP-1) stimulates insulin secretion from the pancreas but also has extra-pancreatic effects. GLP-1 may stimulate glucose uptake in cultured muscle cells but the mechanism is not clearly defined. Furthermore, while the pancreatic effects of GLP-1 are glucose-dependent......, the glucose-dependency of its extra-pancreatic effects has not been examined....

  11. Ocular vergence measurement in projected and collimated simulator displays.

    Science.gov (United States)

    Morahan, P; Meehan, J W; Patterson, J; Hughes, P K

    1998-09-01

    The purpose of this study was to investigate electrooculography (EOG) as a measurement of ocular vergence in both collimated and projected simulator environments. The task required participants to shift their gaze between a central fixation point and a target appearing at one of three eccentricities. EOG was effective in recording ocular vergence. The EOG results were similar between collimated and projected displays, except for differences in vergence changes during lateral movement of the eyes, and ocular excursions downward elicited a greater EOG response than the reverse upward movement. The computer-based technique of recording vergence was found to produce measurable traces from a majority of participants. The technique has potential for further development as a tool for measuring ocular vergence in virtual environments where methods that require the wearing of head-mounted apparatus to track ocular structures (e.g., the pupil), which cannot be worn at the same time as a flight or flight-simulator helmet, are unsuitable.

  12. Effects of diethylcarbamazine on ocular onchocerciasis.

    Science.gov (United States)

    Anderson, J; Fuglsang, H; de C Marshall, T F

    1976-09-01

    A single 10-14 day course of diethylcarbamazine (DEC) was given under betamethazone cover to 18 patients (Group A) with ocular onchocerciasis, and the effects were studied in detail over 1-2 years. A comparison was made with the findings in 21 patients (Group B) who received a similar course to be followed by a weekly suppressive 100-200 mg dose of DEC. A further 18 patients (Group C) served as controls. The initial DEC course provoked severe general reactions, but ocular complications could be controlled by betamethazone. The weekly suppressive dose was not acceptable to the majority of patients, and only one young patient with severe iritis who improved during the initial course took the weekly tablet voluntarily over 2 years. The initial DEC course reduced the numbers of microfilariae in the eye and was of temporary benefit to lesions of the anterior segment, but it did not affect lesions of the posterior segment. A possible adverse effect on the optic disc is discussed. Any beneficial long term effect was almost confined to Group B, and to lesions of the anterior segment. The best to hope for in lesions of the posterior segment was arrest of further development. The findings at the end of the trial were as follows: No. of lesions (see article).

  13. Lipid Nanoparticles for Ocular Gene Delivery

    Directory of Open Access Journals (Sweden)

    Yuhong Wang

    2015-06-01

    Full Text Available Lipids contain hydrocarbons and are the building blocks of cells. Lipids can naturally form themselves into nano-films and nano-structures, micelles, reverse micelles, and liposomes. Micelles or reverse micelles are monolayer structures, whereas liposomes are bilayer structures. Liposomes have been recognized as carriers for drug delivery. Solid lipid nanoparticles and lipoplex (liposome-polycation-DNA complex, also called lipid nanoparticles, are currently used to deliver drugs and genes to ocular tissues. A solid lipid nanoparticle (SLN is typically spherical, and possesses a solid lipid core matrix that can solubilize lipophilic molecules. The lipid nanoparticle, called the liposome protamine/DNA lipoplex (LPD, is electrostatically assembled from cationic liposomes and an anionic protamine-DNA complex. The LPD nanoparticles contain a highly condensed DNA core surrounded by lipid bilayers. SLNs are extensively used to deliver drugs to the cornea. LPD nanoparticles are used to target the retina. Age-related macular degeneration, retinitis pigmentosa, and diabetic retinopathy are the most common retinal diseases in humans. There have also been promising results achieved recently with LPD nanoparticles to deliver functional genes and micro RNA to treat retinal diseases. Here, we review recent advances in ocular drug and gene delivery employing lipid nanoparticles.

  14. Boston ocular surface prosthesis: An Indian experience

    Directory of Open Access Journals (Sweden)

    Varsha Madanlal Rathi

    2011-01-01

    Full Text Available Context: Boston ocular surface prosthesis (BOSP is a scleral contact lens used in the management of patients who are rigid gas permeable (RGP failures as with corneal ectasias such as keratoconus and in those patients who have ocular surface disease such as Stevens-Johnson syndrome (SJS. Aim: To report utilization of BOSP in a tertiary eye care center in India. Materials and Methods: We retrospectively reviewed charts of 32 patients who received BOSP from July 2008 to May 2009. Indications for fitting these lenses, improvement in visual acuity (VA before and after lens fitting and relief of symptoms of pain and photophobia were noted. Paired t-test was used for statistical analysis using SPSS version 16.0 for Windows. Results: Thirty-two patients (43 eyes received these lenses. These consisted of 23 eyes of 17 patients who failed RGP trials for irregular astigmatism and corneal ectasia such as keratoconus and post radial keratotomy and scar and 20 eyes of 15 patients with SJS. Mean age of RGP failures was 27.94 years. Pre- and post-BOSP wear mean LogMAR VA was 1.13 and 0.29, respectively, in RGP failures. The P value was statistically significant (P 2 lines in 7/20 eyes (35% with SJS, with improvement in symptoms. Conclusion: BOSP improves VA in patients who have irregular astigmatism as in ectasias and RGP failures and improves vision and symptoms in patients with SJS.

  15. Ocular Involvement in Systemic Autoimmune Diseases.

    Science.gov (United States)

    Generali, Elena; Cantarini, Luca; Selmi, Carlo

    2015-12-01

    Eye involvement represents a common finding in patients with systemic autoimmune diseases, particularly rheumatoid arthritis, Sjogren syndrome, seronegative spondyloarthropathy, and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. The eye is a privileged immune site but commensal bacteria are found on the ocular surface. The eye injury may be inflammatory, vascular or infectious, as well as iatrogenic, as in the case of hydroxychloroquine, chloroquine, corticosteroids, and bisphosphonates. Manifestations may affect different components of the eye, with episcleritis involving the episclera, a thin layer of tissue covering the sclera; scleritis being an inflammation of the sclera potentially leading to blindness; keratitis, referring to corneal inflammation frequently associated with scleritis; and uveitis as the inflammation of the uvea, including the iris, ciliary body, and choroid, subdivided into anterior, posterior, or panuveitis. As blindness may result from the eye involvement, clinicians should be aware of the possible manifestations and their management also independent of the ophthalmologist opinion as the therapeutic approach generally points to the underlying diseases. In some cases, the eye involvement may have a diagnostic implication, as for episcleritis in rheumatoid arthritis, or acute anterior uveitis in seronegative spondyloarthritis. Nonetheless, some conditions lack specificity, as in the case of dry eye which affects nearly 30 % of the general population. The aim of this review is to elucidate to non-ophthalmologists the major ocular complications of rheumatic diseases and their specific management and treatment options.

  16. Ocular changes in pregnant Nigerian women.

    Science.gov (United States)

    Ebeigbe, J A; Ebeigbe, P N; Ighoroje, Ada

    2012-01-01

    Pregnancy results in a lot of hormonal changes in the body and the eyes are no exception. These ocular changes could be physiologic, pathologic or a modification of a pre-existing condition. The aim of this study was to determine physiologic ocular changes that are associated with pregnancy in healthy Nigerian women. A total of 100 women were followed longitudinally through out the course of their pregnancy and 6 weeks postpartum. The women were recruited at 8 weeks of pregnancy at the anti-natal clinic in the Department of Obstetrics and Gynecology, University of Benin Teaching Hospital, Nigeria. The women were aged between 20 and 35 years. Tests carried out included visual acuity, ophthalmoscopy, retinoscopy, and tonometry. The tests were carried out in each of the three trimesters of pregnancy and 6 weeks postpartum. There was a fall in intraocular pressure across the trimesters and this was very significant (Pchanges associated with pregnancy are transient and most tend to resolve postpartum, with values returning to near pre-pregnant state.

  17. Fluid transport phenomena in ocular epithelia.

    Science.gov (United States)

    Candia, Oscar A; Alvarez, Lawrence J

    2008-03-01

    This article discusses three largely unrecognized aspects related to fluid movement in ocular tissues; namely, (a) the dynamic changes in water permeability observed in corneal and conjunctival epithelia under anisotonic conditions, (b) the indications that the fluid transport rate exhibited by the ciliary epithelium is insufficient to explain aqueous humor production, and (c) the evidence for fluid movement into and out of the lens during accommodation. We have studied each of these subjects in recent years and present an evaluation of our data within the context of the results of others who have also worked on electrolyte and fluid transport in ocular tissues. We propose that (1) the corneal and conjunctival epithelia, with apical aspects naturally exposed to variable tonicities, are capable of regulating their water permeabilities as part of the cell-volume regulatory process, (2) fluid may directly enter the anterior chamber of the eye across the anterior surface of the iris, thereby representing an additional entry pathway for aqueous humor production, and (3) changes in lens volume occur during accommodation, and such changes are best explained by a net influx and efflux of fluid.

  18. Ocular toxoplasmosis in immunosuppressed nonhuman primates

    Energy Technology Data Exchange (ETDEWEB)

    Holland, G.N.; O' Connor, G.R.; Diaz, R.F.; Minasi, P.; Wara, W.M.

    1988-06-01

    To investigate the role of cellular immunodeficiency in recurrent toxoplasmic retinochoroiditis, six Cynomolgus monkeys (Macaca fascicularis) with healed toxoplasmic lesions of the retina were immunosuppressed by total lymphoid irradiation. Three months prior to irradiation 30,000 Toxoplasma gondii organisms of the Beverley strain had been inoculated onto the macula of eye in each monkey via a pars plana approach. Toxoplasmic retinochoroiditis developed in each animal, and lesions were allowed to heal without treatment. During total lymphoid irradiation animals received 2000 centigrays (cGy) over a 7-week period. Irradiation resulted in an immediate drop in total lymphocyte counts and decreased ability to stimulate lymphocytes by phytohemagglutinin. Weekly ophthalmoscopic examinations following irradiation failed to show evidence of recurrent ocular disease despite persistent immunodeficiency. Four months after irradiation live organisms were reinoculated onto the nasal retina of the same eye in each animal. Retinochoroidal lesions identical to those seen in primary disease developed in five of six animals. Toxoplasma organisms therefore were able to proliferate in ocular tissue following the administration of immunosuppressive therapy. This study fails to support the hypothesis that cellular immunodeficiency alone will initiate recurrent toxoplasmic retinochoroiditis. Results suggest that reactivation of disease from encysted organisms involves factors other than suppression of Toxoplasma proliferation. If reactivation occurs by other mechanisms, however, cellular immunodeficiency then may allow development of extensive disease.

  19. Effects of suramin on ocular onchocerciasis.

    Science.gov (United States)

    Anderson, J; Fuglsang, H; de C Marshall, T F

    1976-09-01

    39 patients (Group A) with ocular onchocerciasis in the Sudan-savanna of north Cameroon were given 4-6 g of suramin and followed in detail over 1-2 years. 39 other patients (Group B) received suramin followed 2 weeks later by a 6-7 day course of diethylcarbamazine (DEC). A further 18 patients (Group C) received placebo injections and were followed in the same way by the same observers. Suramin caused serious general reactions among the 100 patients who started the course - 1 case of stomatitis, 1 exfoliative dermatitis, and several cases of severe prostration, among which 2 ended fatally. These reactions underline the urgency for further studies on the toxicity of suramin, which is without doubt an efficient macro- and micro-filaricidal drug. Changes which occurred in the ocular lesions are described in detail. There was an initial aggravation of punctate and sclerosing keratitis, and sometimes a serious aggravation or development of anterior uveitis, corresponding to the peak microfilaricidal effect of the drug. The possibility of a simultaneous adverse effect on the optic disc is discussed. Despite these reactions, which might have been avoided by prior elimination of microfilariae by DEC, the eyes were in general quieter at 3 months and thereafter than before treatment. However, no posterior segment lesion improved after suramin, and the majority remained unchanged. The findings at the end of the trial were as follows: No. of lesions (see article).

  20. Fisiopatología y técnicas de registro de los movimientos oculares Physiopathology and recording techniques of ocular movements

    Directory of Open Access Journals (Sweden)

    L. Gila

    2009-01-01

    Full Text Available En el control de la motilidad ocular intervienen varios sistemas funcionales. Los reflejos vestíbulo-oculares y optocinéticos son respuestas automáticas para compensar los movimientos de la cabeza y del entorno visual y poder estabilizar la imagen retiniana sobre un determinado punto de fijación. Los movimientos sacádicos son rápidos desplazamientos de la fijación de un punto a otro del campo visual. Los movimientos de persecución lenta consisten en el seguimiento de estímulos móviles con la mirada. Finalmente, existen movimientos involuntarios de muy escasa amplitud que se producen durante el mantenimiento de la fijación. Cada modalidad funcional de movimiento depende de circuitos neuronales específicos que trabajan coordinadamente para codificar la contracción de los músculos oculomotores correspondiente a la posición adecuada en cada momento. Estos sistemas neuronales pueden verse alterados por múltiples procesos neurológicos de diferente naturaleza y localización dando lugar a una variada gama de trastornos oculomotores. Se revisan los aspectos más destacados de la fisiopatología y de los sistemas de registro de los movimientos oculares.A number of functional systems are involved in the control of eye movements. The vestibulo-ocular and optokinetic reflexes are automatic responses that compensate for the movements of the head and those of the visual environment in order to stabilize the retinal image on a given fixation point. The saccadic movements are quick displacements of fixation from one to another point in the visual field. The smooth pursuit movements consist in the gaze following a moving target. Finally, there are some involuntary movements of very small amplitude during fixation maintenance. Each functional modality of movement depends on specific neuronal circuits that work in a coordinated manner for encoding the contraction of the oculomotor muscles to reach an adequate position at every moment. These

  1. Higgs Pair Production in Models with Universal Extra Dimensions

    CERN Document Server

    de Sandes, Hiroshi

    2007-01-01

    In this letter we study the process of gluon fusion into a pair of Higgs bosons in a model with one universal extra dimension. We find that the contributions from the extra top quark Kaluza-Klein excitations lead to a Higgs pair production cross section that can be significantly altered compared to the Standard Model value for small values of the compactification scale.

  2. 29 CFR 541.604 - Minimum guarantee plus extras.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Minimum guarantee plus extras. 541.604 Section 541.604 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS... SALES EMPLOYEES Salary Requirements § 541.604 Minimum guarantee plus extras. (a) An employer may...

  3. Direct Detection of Extra-Solar Comets is Possible

    OpenAIRE

    Jura, M.

    2005-01-01

    The dust tails of comets similar to Hale-Bopp can scatter as much optical light as does the Earth. Space-based observatories such as the Terrestrial Planet Finder or Darwin that will detect extra-solar terrestrial planets also will be able to detect extra-solar comets.

  4. Fundamental and composite scalars from extra dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Aranda, Alfredo [Dual C-P Institute of High Energy Physics, Facultad de Ciencias, Universidad de Colima, Bernal Diaz del Castillo 340, Colima, Colima (Mexico)], E-mail: fefo@ucol.mx; Diaz-Cruz, J.L. [Dual C-P Institute of High Energy Physics, Facultad de Ciencias, Universidad de Colima, Bernal Diaz del Castillo 340, Colima, Colima (Mexico); Dual C-P Institute of High Energy Physics, Facultad de Ciencias Fisico-Matematicas, BUAP, Apdo. Postal 1364, C.P. 72000 Puebla, Pue (Mexico)], E-mail: lorenzo.diaz@fcfm.buap.mx; Hernandez-Sanchez, J. [Dual C-P Institute of High Energy Physics, Centro de Investigacion en Matematicas, Universidad Autonoma del Estado de Hidalgo, Carretera Pachuca-Tulancingo km. 4.5, C.P. 42184, Pachuca, Hidalgo (Mexico)], E-mail: jaimeh@uaeh.edu.mx; Noriega-Papaqui, R. [Dual C-P Institute of High Energy Physics, Instituto de Fisica, Universidad Nacional Autonoma de Mexico, Apdo. Postal 20-364, 01000 Mexico D.F. (Mexico)], E-mail: rnoriega@fisica.unam.mx

    2007-12-13

    We discuss a scenario consisting of an effective 4D theory containing fundamental and composite fields. The strong dynamics sector responsible for the compositeness is assumed to be of extra dimensional origin. In the 4D effective theory the SM fermion and gauge fields are taken as fundamental fields. The scalar sector of the theory resembles a bosonic topcolor in the sense there are two scalar Higgs fields, a composite scalar field and a fundamental gauge-Higgs unification scalar. A detailed analysis of the scalar spectrum is presented in order to explore the parameter space consistent with experiment. It is found that, under the model assumptions, the acceptable parameter space is quite constrained. As a part of our phenomenological study of the model, we evaluate the branching ratio of the lightest Higgs boson and find that our model predicts a large FCNC mode h{yields}tc, which can be as large as O(10{sup -3}). Similarly, a large BR for the top FCNC decay is obtained, namely BR(t{yields}c+H){approx_equal}10{sup -4}.

  5. Girls and war: an extra vulnerability.

    Science.gov (United States)

    Black, M

    1998-01-01

    It is no longer possible to consider the raping of girls as an isolated atrocity of war. In Uganda, guerrilla forces have kidnapped 6000-10,000 children and have forced the "most desirable" girls to become "wives" of warlords. Girls who manage to escape are deeply traumatized and suffer ill health as well as possible social ostracism. In refugee camps, recognition that adolescent girls face special risks of rape and of engaging in the informal prostitution that may expose them to HIV/AIDS has led to the introduction of new measures to increase female security. Families in refugee camps in Burundi and Somalia protect female honor by submitting their daughters to very early marriage, which also abuses the girls' rights. Girls conscripted to military groups are forced to transport materials, cook, or help loot villages. In conditions of war, even girls who remain at home protected by their families must assume extra responsibilities, especially if men go off to fight leaving women with the agricultural and livestock burdens. Girls will be the first children withdrawn from school to help keep the household afloat. Girls and women are also expected to tend those wounded by the very war that destroys the health care services that are vital to meet women's reproductive needs. Efforts are being made to identify rape as a specific war crime, and these efforts should be extended to the kidnapping and forced recruitment of children into combat roles. Moral codes must be reestablished, even if they are only nominal at present.

  6. Diphoton Resonance from a Warped Extra Dimension

    CERN Document Server

    Bauer, Martin; Neubert, Matthias

    2016-01-01

    We argue that extensions of the Standard Model (SM) with a warped extra dimension, which successfully address the hierarchy and flavor problems of elementary particle physics, can provide an elegant explanation of the 750 GeV diphoton excess recently reported by ATLAS and CMS. A gauge-singlet bulk scalar with O(1) couplings to fermions is identified as the new resonance S, and the vector-like Kaluza-Klein excitations of the SM quarks and leptons mediate its loop-induced couplings to photons and gluons. The electroweak gauge symmetry almost unambiguously dictates the bulk matter content and hence the hierarchies of the S->\\gamma\\gamma, WW, ZZ, Z\\gamma, t\\bar t and dijet decay rates. We find that the S->Z\\gamma decay mode is strongly suppressed, such that Br(S->Z\\gamma)Br(S->\\gamma\\gamma)S->\\gamma\\gamma signal requires Kaluza-Klein masses in the multi-TeV range, in perfect agreement with bounds from flavor physics and electroweak precision observables.

  7. Gravitation, holographic principle, and extra dimensions

    CERN Document Server

    Caimmi, R

    2016-01-01

    Within the context of Newton's theory of gravitation, restricted to point-like test particles and central bodies, stable circular orbits in ordinary space are related to stable circular paths on a massless, unmovable, undeformable vortex-like surface, under the action of a tidal gravitational field along the symmetry axis. An interpretation is made in the light of a holographic principle, in the sense that motions in ordinary space are connected with motions on a selected surface and vice versa. Then ordinary space is conceived as a 3-hypersurface bounding a $n$-hypervolume where gravitation takes origin, within a $n$-hyperspace. The extension of the holographic principle to extra dimensions implies the existence of a minimum distance where test particles may still be considered as distinct from the central body. Below that threshold, it is inferred test particles lose theirs individuality and "glue" to the central body via unification of the four known interactions and, in addition, (i) particles can no long...

  8. Diphoton resonance from a warped extra dimension

    Science.gov (United States)

    Bauer, Martin; Hörner, Clara; Neubert, Matthias

    2016-07-01

    We argue that extensions of the Standard Model (SM) with a warped extra dimension, which successfully address the hierarchy and flavor problems of elementary particle physics, can provide an elegant explanation of the 750 GeV diphoton excess recently reported by ATLAS and CMS. A gauge-singlet bulk scalar with {O} (1) couplings to fermions is identified as the new resonance S, and the vector-like Kaluza-Klein excitations of the SM quarks and leptons mediate its loop-induced couplings to photons and gluons. The electroweak gauge symmetry almost unambiguously dictates the bulk matter content and hence the hierarchies of the Sto γ γ, W W,ZZ,Zγ, toverline{t} and dijet decay rates. We find that the S → Zγ decay mode is strongly suppressed, such that Br( S → Zγ) /Br( S → γγ) converge and can be calculated in closed form with a remarkably simple result. Reproducing the observed pp → S → γγ signal requires Kaluza-Klein masses in the multi-TeV range, consistent with bounds from flavor physics and electroweak precision observables.

  9. Brane Stabilization and Regionality of Extra Dimensions

    CERN Document Server

    Jacobs, David M; Tolley, Andrew J

    2012-01-01

    Extra dimensions are a common feature of beyond the Standard Model physics. In a braneworld scenario, local physics on the brane can depend strongly on the brane's location within the bulk. Generically, the relevant properties of the bulk manifold for the physics on/of the brane are neither local nor global, but depend on the structure of finite regions of the bulk, even for locally homogeneous and isotropic bulk geometries. In a recent work, various mechanisms (in a braneworld context) were considered to stabilize the location of a brane within bulk spaces of non-trivial topology. In this work we elaborate on and generalize that work by considering additional bulk and brane dimensionalities as well as different boundary conditions on the bulk scalar field that provides a Casimir force on the brane, providing further insight on this effect. In D=2+1 (D=5+1) we consider both local and global contributions to the effective potential of a 1-brane (4-brane) wrapped around both the 2-dimensional hyperbolic horn an...

  10. LHC Signals from Warped Extra Dimensions

    Energy Technology Data Exchange (ETDEWEB)

    Agashe, K.; Belyaev, A.; Krupovnickas, T.; Perez, G.; Virzi, J.

    2006-12-06

    We study production of Kaluza-Klein gluons (KKG) at the Large Hadron Collider (LHC) in the framework of a warped extra dimension with the Standard Model (SM) fields propagating in the bulk. We show that the detection of KK gluon is challenging since its production is suppressed by small couplings to the proton's constituents. Moreover, the KK gluon decaysmostly to top pairs due to an enhanced coupling and hence is broad. Nevertheless, we demonstrate that for MKKG<~;; 4 TeV, 100 fb-1 of data at the LHC can provide discovery of the KK gluon. We utilize a sizeable left-right polarization asymmetry from the KK gluon resonance to maximize the signal significance, and we explore the novel feature of extremely highly energetic"top-jets." We briefly discuss how the detection of electroweak gauge KK states (Z/W) faces a similar challenge since their leptonic decays ("golden" modes) are suppressed. Our analysis suggests that other frameworks, for example little Higgs, which rely on UV completion via strong dynamics might face similar challenges, namely (1) Suppressed production rates for the new particles (such as Z'), due to their"lightfermion-phobic" nature, and (2) Difficulties in detection since the new particles are broad and decay predominantly to third generation quarks and longitudinal gauge bosons.

  11. Extra cellular matrix features in human meninges.

    Science.gov (United States)

    Montagnani, S; Castaldo, C; Di Meglio, F; Sciorio, S; Giordano-Lanza, G

    2000-01-01

    We collected human fetal and adult normal meninges to relate the age of the tissue with the presence of collagenous and non-collagenous components of Extra Cellular Matrix (ECM). Immunohistochemistry led us to observe some differences in the amount and in the distribution of these proteins between the two sets of specimens. In particular, laminin and tenascin seem to be expressed more intensely in fetal meninges when compared to adult ones. In order to investigate whether the morphofunctional characteristics of fetal meninges may be represented in pathological conditions we also studied meningeal specimens from human meningiomas. Our attention was particularly focused on the expression of those non-collagenous proteins involved in nervous cell migration and neuronal morphogenesis as laminin and tenascin, which were present in lesser amount in normal adult specimens. Microscopical evidences led us to hipothesize that these proteins which are synthesized in a good amount during the fetal development of meninges can be newly produced in tumors. On the contrary, the role of tenascin and laminin in adult meninges is probably only interesting for their biophysical characteristics.

  12. Muscle pain

    African Journals Online (AJOL)

    Causes of muscle pain include stress, physical activity, infections, hyper or .... Acupuncture. It is a traditional Chinese-based therapeutic method which ..... and Spinal Mechanisms of Pain and Dry Needling Mediated Analgesia: A Clinical.

  13. PROFILE OF OCULAR TRAUMA IN UTTARAKHAND, A HOSPITAL BASED STUDY.

    Directory of Open Access Journals (Sweden)

    Renu Dhasmana

    2013-01-01

    Full Text Available Background: Although ocular trauma is preventable public health problem throughout the world it is still one of the common causes of ophthalmic morbidity and monocular blindness. There are no published studies on pattern and severity of ocular trauma in Uttarakhand. The present study analyzes the pattern and visual outcome of ocular trauma in this region. Methods: Study design: Prospective hospital-based study. Settings: Patients of ocular trauma presenting to Ophthalmology OPD and emergency department of Himalayan Institute of Medical Sciences, Dehradun. Participants: All ocular injury patients seen for the first time during the period January to December 2008. Results: A total of 88 patients, and 103 eyes, were studied. Men had two fold higher rate of ocular injury than women. The mean age of presentation was 31.2 + 13.6 years (range: 6 - 80 years. The predominant age group of patients was 21-40 years, 55.29 % (n = 47. Eye injuries related to road traffic accident were seen in 37.86% of eyes. Industrial workers were more frequently involved in ocular trauma (23.86%. Closed globe injuries were noted in 55 eyes (53.39% and open globe injuries were noted in 40 eyes (38.83%. Eight eyes (7.76% suffered from chemical injuries. The initial presenting visual acuity of patients with blunt ocular trauma was better than penetrating injury. Eye with better visual acuity at presentation had better visual prognosis at 6 months. Conclusion: Ocular injuries were common in young males. Road traffic accidents related eye injuries were noted in significant number of cases. Strict implementation of traffic rules, health education and preventive strategies may help to decrease the occurrence of ocular injuries.

  14. Complicações oculares da terapêutica com a cloroquina e derivados Ocular complications of chloroquine and derivatives therapy

    Directory of Open Access Journals (Sweden)

    Augusto Cézar Lacava

    2010-08-01

    gastrointestinal, nervous and skeletal muscular systems and the skin. Ocular adverse reactions are: photophobia, cornea verticillata, poliosis, cataract, extraocular muscle palsy, anterior uveitis, toxic maculopathy and optical neuritis. PURPOSE: Bibliography review of complications due to the use of chloroquine and its derivatives. To analyze the current practice and propedeutics' evolution. To suggest practical managements for early toxicity signs. METHODS: Bibliographic review through research on MEDLINE, PUBMED, LILACS and SciELO database. DISCUSSION: All exams that can be used to screen ocular adverse reactions are described, such as: complete ophthalmologic exam, with emphasis on biomicroscopy and indirect binocular ophthalmoscopy, computerized visual field, Amsler grid testing and color vision testing, electrophysiological exams, polarimetry and optical coherence tomography. A description of maculopathy is presented, focusing on epidemiology, risk factors, histopathology and propedeutics. Chemical structure and the differences between 4-aminoquinolone derivatives are described. CONCLUSION: All patients using chloroquine and its derivatives must be followed-up and documented since the beginning of the therapy until they reach a cumulative dose above 100 grams. The higher the cumulative dose, the more we must be concerned with patient follow-up.

  15. Protección ocular: importancia y uso Eye protection: importance and use

    Directory of Open Access Journals (Sweden)

    Cristina Serrano Ramos

    2008-12-01

    Full Text Available La traumatología ocular supone el 10% de la traumatología general en España, siendo los accidentes oftalmológicos de origen laboral en su mayoría. Nuestro objetivo es conocer la prevalencia y etiología en nuestro medio, proponiendo medidas preventivas para disminuirlos en número y gravedad. Realizamos un estudio descriptivo trasversal en 41 trabajadores atendidos en un Servicio de Urgencias Oftalmológicas en un Hospital del Servicio Público de Salud de la Comunidad de Madrid durante el mes de Abril de 2006. Mediante cuestionario específico analizamos las siguientes variables: edad sexo, profesión, sector, dispensación y uso de protección ocular, reincidencia, diagnóstico y asistencia médica Los resultado obtenidos muestran que un 25.6% de accidentes oculares son de origen laboral, que se dan en el 87 % en varones, con una edad media de 35 años; pertenecen al sector de la construcción un 85.4 %, que maneja equipo de soldadura o radial. El diagnóstico más frecuente es el impacto de cuerpo extraño y se trataba de accidente reiterado en el 32% de los casos. No posee protección ocular el 51.2% y de los que la poseen no la usa el 48%. Por todo ello nuestro esfuerzo debe encaminarse a la información y formación sobre la protección ocular, en trabajador y empresario El hecho de que el 46% podría haber sido tratado de forma ambulatoria supone que médico del trabajo debe estar entrenado en el manejo de la traumatología ocular por su frecuencia y la necesidad de tratamiento inmediato en el lugar de trabajo.Ten percent of the overall traumas in Spain are in the eye, these accidents where mostly at work. The aim of our study is to determine the prevalence and etiology in our area and propose preventive measures to decrease the number of accidents and their severity. We conducted a descriptive study in 41 workers attended in an eye emergency department (Hospital San Carlos- April2006 with a specific questionnaire (variables: age

  16. Medial rectus muscle anchoring in complete oculomotor nerve palsy.

    Science.gov (United States)

    Lee, Si Hyung; Chang, Jee Ho

    2015-10-01

    The management of exotropia resulting from complete oculomotor nerve palsy is challenging. Conventional therapeutic interventions, including supramaximal resection and recession, superior oblique tendon resection and transposition, and several ocular anchoring procedures have yielded less-than-adequate results. Here we describe a novel surgical technique of anchoring the medial rectus muscle to the medial orbital wall in combination with lateral rectus disinsertion and reattachment to the lateral orbital wall.

  17. Error bounds from extra precise iterative refinement

    Energy Technology Data Exchange (ETDEWEB)

    Demmel, James; Hida, Yozo; Kahan, William; Li, Xiaoye S.; Mukherjee, Soni; Riedy, E. Jason

    2005-02-07

    We present the design and testing of an algorithm for iterative refinement of the solution of linear equations, where the residual is computed with extra precision. This algorithm was originally proposed in the 1960s [6, 22] as a means to compute very accurate solutions to all but the most ill-conditioned linear systems of equations. However two obstacles have until now prevented its adoption in standard subroutine libraries like LAPACK: (1) There was no standard way to access the higher precision arithmetic needed to compute residuals, and (2) it was unclear how to compute a reliable error bound for the computed solution. The completion of the new BLAS Technical Forum Standard [5] has recently removed the first obstacle. To overcome the second obstacle, we show how a single application of iterative refinement can be used to compute an error bound in any norm at small cost, and use this to compute both an error bound in the usual infinity norm, and a componentwise relative error bound. We report extensive test results on over 6.2 million matrices of dimension 5, 10, 100, and 1000. As long as a normwise (resp. componentwise) condition number computed by the algorithm is less than 1/max{l_brace}10,{radical}n{r_brace} {var_epsilon}{sub w}, the computed normwise (resp. componentwise) error bound is at most 2 max{l_brace}10,{radical}n{r_brace} {center_dot} {var_epsilon}{sub w}, and indeed bounds the true error. Here, n is the matrix dimension and w is single precision roundoff error. For worse conditioned problems, we get similarly small correct error bounds in over 89.4% of cases.

  18. Sub-lethal Ocular Trauma (SLOT): Establishing a Standardized Blast Threshold to Facilitate Diagnostic, Early Treatment, and Recovery Studies for Blast Injuries to the Eye and Optic Nerve

    Science.gov (United States)

    2015-11-01

    PartName Density (g/mm3) Youngs Modulus (Mpa) Bulk Modulus (Mpa) Poissons Ratio Source of Material Properties Aqueous 0.0010 - 2200 - Rossi... muscles . Table 14. Mechanical Properties of the Ocular Tissues Density kg/m3 Young’s Modulus (Pa) Poisson’s Ratio Sound...Unlimited The views, opinions and/or findings contained in this report are those of the author( s ) and should not be construed as an official Department of

  19. Ocular manifestation in treated multibacillary Hansen's disease.

    Science.gov (United States)

    Parikh, Rajul; Thomas, Saju; Muliyil, Jayaprakash; Parikh, Shefali; Thomas, Ravi

    2009-11-01

    To report the prevalence of ocular morbidity in patients with treated multibacillary Hansen's disease (HD) using modern ophthalmic diagnostic techniques in a rural community endemic for HD. Cross-sectional, observation study. All patients with multibacillary HD who had completed their multidrug therapy and who resided in 4 defined geographical areas in Vellore, Tamil Nadu, India. All participants underwent a complete eye examination that included slit-lamp examination, esthesiometry, gonioscopy, applanation tonometry, and dilated fundus examination, including a stereobiomicroscopic examination of the fundus at an ophthalmic center set up for that purpose. Glaucoma suspects underwent automated perimetry using a Humphrey Field Analyzer (Humphrey Instruments, San Leandro, CA). The prevalence of various ocular disease parameters were reported as mean value with 95% confidence interval. The difference of disease prevalence between various leprosy groups was compared using an unpaired t test. The association between eye symptoms and potentially sight-threatening complications was analyzed using the chi-square test. Three hundred eighty-six of the 446 patients with multibacillary HD residing in the defined areas were evaluated. Four patients (1.04%; 95% confidence interval [CI], 0.0%-2.0%) were bilaterally blind; 33 (8.55%; 95% CI, 5.8%-11.3%) had unilateral blindness. Mean intraocular pressure was 12 mmHg (standard deviation, 4.1 mmHg), and prevalence of glaucoma was 3.6% (95% CI, 1.8%-5.5%). Potentially sight-threatening (PST) pathologic features (corneal anesthesia, lagophthalmos, uveitis, scleritis, and advanced glaucoma) were present in 10.4% (95% CI, 7.4%-13.4%) of patients. Significant cataracts occurred 3 times more frequently in those with polar lepromatous leprosy. The odds ratio for PST pathology in the presence of patient-reported symptoms (pain, redness, inability to close eye, burning, and irritation) was 2.9 (95% CI, 1.34-6.26). Patients who have completed

  20. Consideraciones del trauma ocular infantil Considerations on the ocular trauma in children

    Directory of Open Access Journals (Sweden)

    Alejandro Arias Díaz

    2012-01-01

    Full Text Available Se realizó una descripción de los aspectos clínicos y el manejo terapéutico del trauma ocular en edades pediátricas. Se identifican las particularidades a abordar en estos pacientes con presencia de cataratas traumáticas y/o heridas penetrantes corneales, por las diferencias en el manejo de las mismas en estas edades y en la adultez. Se hace énfasis en el hifema traumático.The clinical aspects and the treatment management of the ocular trauma at pediatric ages were described. Those particularities to be taken into account when approaching these patients who suffer traumatic cataracts and/or penetrating corneal injuries were indentified, on the account of the differences in the management of this disease between children and adults. Emphasis was made on the description of traumatic hyphema.

  1. Iontoforese no transporte ocular de drogas Iontophoresis for ocular drug delivery

    Directory of Open Access Journals (Sweden)

    Sílvia Ligório Fialho

    2004-10-01

    Full Text Available O método mais comum de administração de drogas no olho é por meio de colírios. Entretanto, por este método, não é possível atingir a concentração terapêutica nos fluidos e tecidos posteriores do olho. A administração sistêmica apresenta reduzido acesso ao segmento posterior do olho devido à presença das barreiras oculares. Injeções subconjuntivais e retrobulbares não são capazes de proporcionar níveis adequados da droga, e a injeção intravítrea é método invasivo, inconveniente e que apre-senta riscos de perfuração do bulbo ocular ou descolamento da retina. A iontoforese, no entanto, apresenta-se como alternativa para o transporte de doses terapêuticas de drogas para o segmento posterior do olho. A iontoforese é uma técnica que consiste na administração de drogas para o organismo através dos tecidos, utilizando um campo elétrico. O eletrodo ativo, que se encontra em contato com a droga, é colocado no local a ser tratado, e um segundo eletrodo, com a finalidade de fechar o circuito elétrico, é colocado em outro local do organismo. O campo elétrico facilita o transporte da droga, que deve se encontrar, preferencialmente, na forma ionizada. A iontoforese pode ser considerada como um método seguro e não invasivo de transporte de drogas para locais específicos do olho. Aplicada experimentalmente para o tratamento de doenças oculares, esta técnica tem evoluído muito nos últimos anos e, atualmente, testes clínicos de fase III encontram-se em andamento.The most traditional method of ocular drug delivery is through the use of eyedrops. However, by this method, the therapeutic concentration in deep ocular fluids and tissues can not be efficiently reached. Systemic administration presents poor access to the posterior segment of the eye due to ocular barriers. Subconjuntival and retrobulbar injections are not able to produce adequate levels of the drug, and intravitreal injection is an invasive and problematic

  2. Retroperitoneal abscess: an extra-abdominal manifestation.

    Science.gov (United States)

    Mallia, Alvin James; Ashwood, Neil; Arealis, George; Galanopoulos, Ilias

    2015-01-09

    Retroperitoneal abscesses are unusual occurrences with occult and insidious presentations. There is often a lack of abdominal signs, leading to delays in drainage and high mortality rates. We report a case of thigh emphysema in an 88-year-old patient with diabetes. Prior to admission the patient reported a vague 4-week history of left thigh pain and an inability to fully weight bear. She presented to our emergency department with sepsis and acute kidney impairment. An X-ray of her left femur revealed widespread gas between muscular planes. A retroperitoneal abscess involving the left renal fossa, psoas, iliacus and upper thigh muscles was revealed on an urgent CT scan. The patient was transferred to intensive care unit (ICU) and underwent an emergency drainage. Despite ICU the patient died 2 days after admission.

  3. An unusual extraocular muscle anomaly in a patient with Crouzon's disease.

    OpenAIRE

    SNIR, M.; Gilad, E.; Ben-Sira, I

    1982-01-01

    A 29-year-old female suffering from Crouzon's disease was admitted to hospital with retinal detachment in the right eye. At operation agenesis of 4 extraocular muscles (superior and inferior recti and obliquus) was found, together with abnormal insertion of the 2 horizontal muscles. The same extraocular muscular abnormalities were found in the left eye. We suggest here a new surgical treatment in such cases and discuss the reasons for the limitation of ocular motility in such cases.

  4. An unusual extraocular muscle anomaly in a patient with Crouzon's disease.

    Science.gov (United States)

    Snir, M.; Gilad, E.; Ben-Sira, I.

    1982-01-01

    A 29-year-old female suffering from Crouzon's disease was admitted to hospital with retinal detachment in the right eye. At operation agenesis of 4 extraocular muscles (superior and inferior recti and obliquus) was found, together with abnormal insertion of the 2 horizontal muscles. The same extraocular muscular abnormalities were found in the left eye. We suggest here a new surgical treatment in such cases and discuss the reasons for the limitation of ocular motility in such cases. Images PMID:7066280

  5. Headaches with ocular localization and involvement Cefaleas de localización y compromiso oculares

    Directory of Open Access Journals (Sweden)

    Marta Lucía Muñoz Cardona

    2005-04-01

    Full Text Available The most frequent primary headaches, including migraine variants, and intrinsic optic nerve disorders that produce headache, are reviewed. The latter are often accompanied by autonomic nervous system alterations which lead to vasomotor changes, frequently present in neuralgic processes known as headaches with disautonomic involvement. Epidemiological, semiological, clinical, and therapeutical aspects of different cranial, facial and ocular diseases that produce headache are included. Some physiopathological elements that may help to analyze painful craniofacial processes are discussed. Secondary headaches and common facial neuralgias, on the other hand, are also considered because they may confuse the differential diagnosis. Se revisan las cefaleas primarias más frecuentes que comprometen las estructuras oculares y vecinas al globo ocular, las variantes de la migraña y las alteraciones propias del nervio óptico que alteran la función visual y que se acompañan no solamente de síntomas dolorosos sino también de trastornos vasomotores debidos a alteraciones del sistema nervioso autónomo que suelen ser comunes en algunos procesos neurálgicos llamados ahora cefaleas con compromiso disautonómico. En este artículo se comentan los elementos epidemiológicos de las diferentes enfermedades craneales, faciales y oculares que cursan con cefalea; las diferencias clínicas entre las mismas y su presentación semiológica, al igual que algunos elementos terapéuticos. Se discuten además algunos elementos fisiopatológicos de gran utilidad en el análisis de los procesos dolorosos craneofaciales y el perfil temporal de los mismos; también se comentan algunas cefaleas secundarias que comparten con las primarias elementos que se prestan a confusión en la clínica. Finalmente, se hace un análisis de las neuralgias faciales comunes.

  6. A multidisciplinary approach for rehabilitation following ocular trauma

    Directory of Open Access Journals (Sweden)

    Pradeep Kumar

    2014-11-01

    Full Text Available Ocular trauma is a very common incidence that occurs in up to 67% of patients with maxillofacial trauma. It results in life-long agony of not being like others with two eyes, which can see and admire the nature's beauty. This article reports on a case of a 23-year-old male patient with phthisis bulbi, resulting from ocular trauma. The patient was rehabilitated aesthetically by fabrication of custom-made ocular prosthesis for his traumatically injured right eye. The patient was pleased with the aesthetic outcome, comfort, and mobility offered by the custom ocular prosthesis. There were no complications with regard to health of underlying residual ocular tissues and there was no need of relining of the prosthesis at 6 month recall appointment. Rehabilitation of patients with ocular trauma requires a multidisciplinary approach involving ophthalmologist, psychologist, and skilled maxillofacial prosthodontist. Custom-made ocular prosthesis fitted over the phthisical globe seems to be a highly positive, logical, noninvasive, and beneficial approach to increase mobility to the prosthesis, improve the cosmetic appearance and psychological well-being of the patient.

  7. Ocular manifestations in Hansen’s disease- a clinical study

    Directory of Open Access Journals (Sweden)

    Christina Samuel, Sundararajan D

    2014-11-01

    Full Text Available Leprosy or Hansen’s disease is a chronic mildly contagious granulomatous disease of tropical and subtropical regions caused by the rod shaped bacillus, Mycobacterium leprae. It affects the skin, peripheral nerves in the hands and feet, mucous membrane of nose, throat and eyes. When left untreated, it is capable of producing various deformities and disfigurements. Aim: To study the ocular involvement in patients with Leprosy under the parameters of age group, sex type and duration of leprosy. To study the different ocular manifestations and identify the potentially sight threatening lesions and provide early management. Methods: This was a prospective study which included 50 cases diagnosed with Hansen’s disease. Detailed history and thorough clinical examination was done. Potentially sight threatening lesions were managed conservatively or surgically. Results: Out of 50 cases of Leprosy, 58% had ocular involvement and majority were in the age group 21-40years. Ocular involvement was predominantly seen in Lepromatous type with 35% having ocular lesions. The most common ocular manifestation observed was superciliary madarosis (48%. Potentially sight threatening lesions accounted for 72.4% of which lagophthalmos was common. No cases of blindness seen. Conclusion: Visual impairment is preventable in Leprosy if detected early. The risk of ocular complications increases with the duration of the disease, despite being treated with systemic anti-leprosy drugs.

  8. Influence of ocular perfusion pressure fluctuation on glaucoma

    Directory of Open Access Journals (Sweden)

    Min-Zi Ren

    2015-12-01

    Full Text Available AIM:To investigate the influence of ocular perfusion pressure fluctuation on glaucoma. METHODS:Forty patients with primary open angle glaucoma from January 2013 to June 2015 in our hospital were used as observation group and 40 families were used as control group. Circadian fluctuation of intraocular pressure, blood pressure and ocular perfusion pressure in 24h were determined to obtain systolic ocular perfusion pressure(SOPP, diastolic ocular perfusion pressure(DOPPand mean ocular perfusion pressure(MOPP. Pearson linear correlation was used to analyze the correlation of circadian MOPP fluctuation with cup-disc ratio, mean defect(MDand the picture standard deviation(PSD. RESULTS:The fluctuation of MOPP, SOPP and DOPP of observation group were significantly higher than those of control group(Pr=-0.389, 95%CI:-0.612~-0.082; P=0.011, was positively correlated with PSD(r=0.512, 95%CI:0.139 ~0.782; P=0.008; no correlation was found between it and the vertical cup-disc ratio(r=0.115, 95%CI:0.056~0.369; P=0.355. CONCLUSION:Ocular perfusion pressure fluctuations in patients with primary open angle glaucoma may reflect the severity of the disease and may make the situation aggravating. Therefore through perfusion pressure monitor in 24h may help us understand the ocular blood flow and the development of primary open-angle glaucoma.

  9. Lateral rectus muscle disinsertion and reattachment to the lateral orbital wall

    OpenAIRE

    Morad, Y.; KOWAL, L.; Scott, A B

    2005-01-01

    Background/aims: Surgical correction of ocular alignment in patients with third cranial nerve paralysis is challenging, as the unopposed lateral rectus muscle often pulls the eye back to exotropia following surgery. The authors present a simple surgical approach to overcome this difficulty. This approach is also applicable to removal of unwanted overactivity of the lateral rectus in Duane syndrome.

  10. Downbeat nystagmus: evidence for enhancement of utriculo-ocular pathways by ocular vestibular evoked myogenic potentials?

    Science.gov (United States)

    Bremova, Tatiana; Glasauer, Stefan; Strupp, Michael

    2015-11-01

    Downbeat nystagmus (DBN) is caused by an impairment of Purkinje cells in the flocculus. The decreased cerebellar inhibitory input affects otolith pathways. Since ocular and cervical vestibular evoked myogenic potentials (o-/cVEMP) test the otoliths, the VEMP were measured in DBN patients and in controls. Sixteen patients with DBN, 14 cerebellar oculomotor disorder patients without DBN (COMD), and 16 healthy controls were examined with o-/cVEMP. Computational modeling was used to predict VEMP differences between groups. DBN patients had significantly higher oVEMP peak-to-peak (PP) amplitudes than COMD patients without DBN and controls. Cervical VEMP did not differ. The computational model of DBN predicted a twofold oVEMP increase for DBN patients. These findings suggest an enhancement of the utriculo-ocular response. The unchanged cVEMP indicate no effect on the otolith-cervical reflex in DBN. Computational modeling suggests that the utriculo-ocular enhancement is caused by an impaired vertical neural integrator resulting in the increased influence of utricular signals. This also explains the gravitational dependence of DBN.

  11. The Impact of Visual Guided Order Picking on Ocular Comfort, Ocular Surface and Tear Function.

    Directory of Open Access Journals (Sweden)

    Angelika Klein-Theyer

    Full Text Available We investigated the effects of a visual picking system on ocular comfort, the ocular surface and tear function compared to those of a voice guided picking solution.Prospective, observational, cohort study.Institutional.A total of 25 young asymptomatic volunteers performed commissioning over 10 hours on two consecutive days.The operators were guided in the picking process by two different picking solutions, either visually or by voice while their subjective symptoms and ocular surface and tear function parameters were recorded.The visual analogue scale (VAS values, according to subjective dry eye symptoms, in the visual condition were significantly higher at the end of the commissioning than the baseline measurements. In the voice condition, the VAS values remained stable during the commissioning. The tear break-up time (BUT values declined significantly in the visual condition (pre-task: 16.6 sec and post-task: 9.6 sec in the right eyes, that were exposed to the displays, the left eyes in the visual condition showed only a minor decline, whereas the BUT values in the voice condition remained constant (right eyes or even increased (left eyes over the time. No significant differences in the tear meniscus height values before and after the commissioning were observed in either condition.In our study, the use of visually guided picking solutions was correlated with post-task subjective symptoms and tear film instability.

  12. Vasoinhibins: novel inhibitors of ocular angiogenesis.

    Science.gov (United States)

    Clapp, Carmen; Thebault, Stéphanie; Arnold, Edith; García, Celina; Rivera, José Carlos; de la Escalera, Gonzalo Martínez

    2008-10-01

    Disruption of the quiescent state of blood vessels in the retina leads to aberrant vasopermeability and angiogenesis, the major causes of vision loss in diabetic retinopathy. Prolactin is expressed throughout the retina, where it is proteolytically cleaved to vasoinhibins, a family of peptides (including the 16-kDa fragment of prolactin) with potent antiangiogenic, vasoconstrictive, and antivasopermeability actions. Ocular vasoinhibins act directly on endothelial cells to block blood vessel growth and dilation and to promote apoptosis-mediated vascular regression. Also, vasoinhibins prevent retinal angiogenesis and vasopermeability associated with diabetic retinopathy, and inactivation of endothelial nitric oxide synthase via protein phosphatase 2A is among the various mechanisms mediating their actions. Here, we discuss the potential role of vasoinhibins both in the maintenance of normal retinal vasculature and in the cause and prevention of diabetic retinopathy and other vasoproliferative retinopathies.

  13. Ocular microtremor measurement system: design and performance.

    Science.gov (United States)

    Sheahan, N F; Coakley, D; Hegarty, F; Bolger, C; Malone, J

    1993-05-01

    The frequency of ocular microtremor (OMT) is related to the functional status of the brain stem, and thus OMT may be useful in the diagnosis and management of brain stem disorders. The paper discusses the design of an OMT measurement system and reports quantitative specifications for three portable systems. All systems use a piezo-electric element as the transducer, which measures the displacement of the sclera during eye rotations. The systems differ in the manner in which the signal is recorded. All systems can detect eye movements corresponding to displacements of the sclera ranging from 12 to over 3000 nm. The frequency responses of all systems are flat (< 2 dB deviation from peak response) between 20 and 150 Hz. The phase response shows deviations (< pi) at the extremes of this range, but qualitative comparison of input and measured signals demonstrates that phase distortion is not excessive. Thus all systems are acceptable for clinical studies involving OMT.

  14. Unusual Presentation of Cutaneous Leishmaniasis: Ocular Leishmaniasis

    Directory of Open Access Journals (Sweden)

    Masoud Doroodgar

    2017-01-01

    Full Text Available The leishmaniases are parasitic diseases that are transmitted to humans by infected female sandflies. Cutaneous leishmaniasis (CL is one of 3 main forms of the disease. CL is the most common form of the disease and is endemic in many urban and rural parts of Iran and usually caused by two species of Leishmania: L. major and L. tropica. We report a case of unusual leishmaniasis with 25 lesions on exposed parts of the body and right eyelid involvement (ocular leishmaniasis. The patient was a 75-year-old male farmer referred to health care center in Aran va Bidgol city. The disease was diagnosed by direct smear, culture, and PCR from the lesions. PCR was positive for Leishmania major.

  15. Development of ocular inserts for cattle.

    Science.gov (United States)

    Greer, R T; Ryoo, J P

    1987-06-01

    Ring shaped ocular inserts have been developed to administer a therapeutic level of tylosin tartrate throughout a five day period to treat pinkeye in cattle. The inserts are based on polyvinyl chloride rings which are dip coated with a copolymer containing the antibiotic (tylosin tartrate). Scanning electron microscope (SEM) characterization of surfaces has been of value to evaluate the presence and extent of surface flaws in the hydrogel coating, and to contribute to improvement in fabrication of the rings to insure the establishment of satisfactory seals at joints, uniformity of microporosity and cross sections, and the absence of significant cracking or flaking. In vitro release rates were determined using thin layer chromatography techniques, and rates were seen to be above a few micrograms of antibiotic per hour for experiments as long as nine days at simulated tear rates as high as 2 milliliters per hour.

  16. Tumor-specific frequencies and ocular melanoma.

    Science.gov (United States)

    Milham, Samuel; Stetzer, David

    2017-01-01

    Specific kilohertz frequencies in the environment from variable frequency drives on electric motors at a liquid natural gas compressor and storage station on a natural gas pipeline seem to be associated with the development of a very rare cancer, ocular melanoma, at a high school and in individuals living or working in a neighborhood near the plant. Primary neutral-to-earth oscilloscope voltage waveforms and spectra measured near the high school were nearly identical to the ground voltage 2.3 miles away at the gas pipeline. Peak frequencies of 7440 and 19,980 Hz were found at both places. The electric utility practice of using the earth as a conduit for return currents facilitated this exposure.

  17. Nutrición y salud ocular

    OpenAIRE

    Olmedilla Alonso, Begoña

    2012-01-01

    El texto está disponible para cualquiera que se registre previamente en http://www.katedrakelloggs.com .- 24.Nutrición y salud ocular 377-388,12 páginas--Manual Práctico de Nutrición y Salud Kellogg’s, obra colectiva de visión multidisciplinar que surge a propuesta del colectivo médico ante la necesidad de recibir formación en materia de nutrición. Existen numerosos manuales de nutrición, pero en esta ocasión se ofrece una edición de consulta rápida, fácil acceso y manejo para utiliz...

  18. OCULAR PATHOLOGY IN PATIENTS AFTER KIDNEY TRANSPLANTATION

    Directory of Open Access Journals (Sweden)

    L. K. Moshetova

    2011-01-01

    Full Text Available Structural changes in eyes are present in all patients with chronic kidney disease. A study to detect ocular patho- logy in patients with end-stage chronic renal failure after kidney transplantation in the early and late postopera- tive period compared with patients receiving replacement therapy with hemodialysis. Revealed that in the early post-transplant period in recipients of kidneyas in patients on hemodialysis, continued angioretinopatiya, 40% of patients had «dry eye syndrome». In the delayed post-transplant period, patients showed significant impro- vement in the retina and retinal vessels, the improvement of spatial-temporal parameters of visual perception. However, a decrease of visual acuity on the background of the development of posterior subcapsular cataract caused by prolonged corticosteroid, and an increased incidence of viral and bacterial conjunctivitis. 

  19. Surgical management of advanced ocular adnexal amyloidosis.

    Science.gov (United States)

    Patrinely, J R; Koch, D D

    1992-06-01

    Ocular adnexal amyloidosis is characterized by amyloid deposition within the deep connective tissue layers of the eyelids, conjunctiva, and anterior orbit. Management of advanced cases has traditionally been unsatisfactory, with either no surgery offered because of fear of hemorrhage or an en bloc resection performed of the entire involved area. We present two cases of advanced periorbital amyloidosis successfully managed by preserving the anatomic planes of the eyelids and meticulously debulking the deposits with a spooned curette. Lax eyelid tendons and aponeuroses were simultaneously repaired, and no sacrifice of eyelid tissues was necessary. One patient remained asymptomatic for 2 years after surgery before developing early reaccumulation in the lower eyelids. The other patient required additional eyelid debulking and ptosis revision 8 months after surgery, but was in stable condition at follow-up 2 years after surgery. This technique offers safe, easily repeatable, nondestructive treatment for advanced periocular amyloidosis.

  20. Nanotechnology approaches for ocular drug delivery

    Directory of Open Access Journals (Sweden)

    Qingguo Xu

    2013-01-01

    Full Text Available Blindness is a major health concern worldwide that has a powerful impact on afflicted individuals and their families, and is associated with enormous socio-economical consequences. The Middle East is heavily impacted by blindness, and the problem there is augmented by an increasing incidence of diabetes in the population. An appropriate drug/gene delivery system that can sustain and deliver therapeutics to the target tissues and cells is a key need for ocular therapies. The application of nanotechnology in medicine is undergoing rapid progress, and the recent developments in nanomedicine-based therapeutic approaches may bring significant benefits to address the leading causes of blindness associated with cataract, glaucoma, diabetic retinopathy and retinal degeneration. In this brief review, we highlight some promising nanomedicine-based therapeutic approaches for drug and gene delivery to the anterior and posterior segments.