WorldWideScience

Sample records for external domino effects

  1. Domino effect analysis using Bayesian networks.

    Science.gov (United States)

    Khakzad, Nima; Khan, Faisal; Amyotte, Paul; Cozzani, Valerio

    2013-02-01

    A new methodology is introduced based on Bayesian network both to model domino effect propagation patterns and to estimate the domino effect probability at different levels. The flexible structure and the unique modeling techniques offered by Bayesian network make it possible to analyze domino effects through a probabilistic framework, considering synergistic effects, noisy probabilities, and common cause failures. Further, the uncertainties and the complex interactions among the domino effect components are captured using Bayesian network. The probabilities of events are updated in the light of new information, and the most probable path of the domino effect is determined on the basis of the new data gathered. This study shows how probability updating helps to update the domino effect model either qualitatively or quantitatively. The methodology is applied to a hypothetical example and also to an earlier-studied case study. These examples accentuate the effectiveness of Bayesian network in modeling domino effects in processing facility. © 2012 Society for Risk Analysis.

  2. Domino Effect: mechanic factors role

    Science.gov (United States)

    Nardi, Alfredo; Tarantino, Umberto; Ventura, Lorenzo; Armotti, Pierantonio; Resmini, Giuseppina; Cozzi, Luisella; Tonini, Greta; Ramazzina, Emilio; Rossini, Maurizio

    2011-01-01

    Summary The rapid onset of the Domino Effect following the first Vertebral Compression Fracture is a direct consequence of the mechanical variations that affect the spine when physiological curves are modified. The degree of kyphosis influences the intensity of the Flexor Moment; this is greater on vertebrae D7, D8 and on vertebrae D12, L1 when the spine flexes. Fractures of D7, D8, D12 and L1 are, by far, the most frequent and also the main cause of the mechanical alterations that can trigger the Domino Effect. For these considerations vertebrae D7, D8, D12 and L1 have to be taken in consideration as “critical". In the case of critical clinical vertebral fractures it is useful to provide an indication for minimally invasive surgical reduction or intrasomatic stabilization. When occurs a fracture of a “critical vertebra”, prompt restoration of the heights leads to a reduction in the Kyphosis Index and therefore in the Flexor Moment, not only of the fractured vertebra but also, in turn, of all the other metameres which, even if morphologically still intact, are structurally fragile; so, through the restoration of the mechanical vertebral proprieties, we can reduce the risk of the Domino Effect. At the same time the prompt implementation of osteoinductive therapy is indispensable in order to achieve rapid and intense reconstruction of the trabecular bone, the strength of which increases significantly in a short period of time. Clinical studies are necessary to confirm the reduction of the domino effect following a fragility fracture of "critical vertebrae" with the restoration of the mechanical properties together with anabolic therapy. PMID:22461815

  3. Domino Effect: mechanic factors role.

    Science.gov (United States)

    Nardi, Alfredo; Tarantino, Umberto; Ventura, Lorenzo; Armotti, Pierantonio; Resmini, Giuseppina; Cozzi, Luisella; Tonini, Greta; Ramazzina, Emilio; Rossini, Maurizio

    2011-05-01

    The rapid onset of the Domino Effect following the first Vertebral Compression Fracture is a direct consequence of the mechanical variations that affect the spine when physiological curves are modified. The degree of kyphosis influences the intensity of the Flexor Moment; this is greater on vertebrae D7, D8 and on vertebrae D12, L1 when the spine flexes. Fractures of D7, D8, D12 and L1 are, by far, the most frequent and also the main cause of the mechanical alterations that can trigger the Domino Effect. For these considerations vertebrae D7, D8, D12 and L1 have to be taken in consideration as "critical". In the case of critical clinical vertebral fractures it is useful to provide an indication for minimally invasive surgical reduction or intrasomatic stabilization. When occurs a fracture of a "critical vertebra", prompt restoration of the heights leads to a reduction in the Kyphosis Index and therefore in the Flexor Moment, not only of the fractured vertebra but also, in turn, of all the other metameres which, even if morphologically still intact, are structurally fragile; so, through the restoration of the mechanical vertebral proprieties, we can reduce the risk of the Domino Effect. At the same time the prompt implementation of osteoinductive therapy is indispensable in order to achieve rapid and intense reconstruction of the trabecular bone, the strength of which increases significantly in a short period of time. Clinical studies are necessary to confirm the reduction of the domino effect following a fragility fracture of "critical vertebrae" with the restoration of the mechanical properties together with anabolic therapy.

  4. Analysis of domino effect in pipelines.

    Science.gov (United States)

    Ramírez-Camacho, J Giovanni; Pastor, Elsa; Casal, Joaquim; Amaya-Gómez, Rafael; Muñoz-Giraldo, Felipe

    2015-11-15

    Parallel pipelines are frequently installed over long distances, due to the difficulty in creating or maintaining the required corridor. This implies that a release in one pipeline can seriously affect another one. The main risks associated with this domino effect are erosion by fluid-sand jets and the thermal action of jet fires. In this paper a survey has been performed on the accidents that have occurred, and the diverse associated domino sequences are analyzed. The probability of occurrence of domino effect is a function of the location of the hole, the jet direction and solid angle, the diameter of both pipelines and the distance between them. A mathematical model has been developed to estimate this probability. The model shows how the probability of domino effect decreases with the distance and diameter of the source pipe, and increases with the diameter of the target pipe. Its frequency can be estimated from this probability and from the frequency of the initiating pipe failure plus, in the case of jet fire impingement, the probability of ignition. The frequency of the target pipe failure thus calculated, always higher than its individual frequency, allows a more realistic risk analysis. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Domino effects within a chemical cluster: a game-theoretical modeling approach by using Nash-equilibrium.

    Science.gov (United States)

    Reniers, Genserik; Dullaert, Wout; Karel, Soudan

    2009-08-15

    Every company situated within a chemical cluster faces domino effect risks, whose magnitude depends on every company's own risk management strategies and on those of all others. Preventing domino effects is therefore very important to avoid catastrophes in the chemical process industry. Given that chemical companies are interlinked by domino effect accident links, there is some likelihood that even if certain companies fully invest in domino effects prevention measures, they can nonetheless experience an external domino effect caused by an accident which occurred in another chemical enterprise of the cluster. In this article a game-theoretic approach to interpret and model behaviour of chemical plants within chemical clusters while negotiating and deciding on domino effects prevention investments is employed.

  6. Domino Magnification

    CERN Document Server

    van Leeuwen, J M J

    2013-01-01

    The conditions are investigated under which a row of increasing dominoes is able to keep tumbling over. The analysis is restricted to the simplest case of frictionless dominoes that only can topple not slide. The model is scale invariant, i.e. dominoes and distance grow in size at a fixed rate, while keeping the aspect ratios of the dominoes constant. The maximal growth rate for which a domino effect exist is determined as a function of the mutual separation.

  7. Enron and the domino effect

    Directory of Open Access Journals (Sweden)

    Ph.D.Professor Paul Marinescu, Afiliation

    2012-05-01

    Full Text Available This paper aims to present the effects of Enron's 2001 collapse has had on the business environment looked upon systemically, analyzing the interdependencies the American giant had with other components of this environment especially those that should have played and important system control role such as audit firms, financial analysts and investment banks. The premises from which we start are that exactly the failure of these control instruments has led to the escalation of the situation up to the point in which the fall becomes inevitable. I believe that this analysis can offer relevant lessons for the key on how the current situation of Greece must be judged, a subject of utmost importance.

  8. On Hospital Wards, Patient Crises May Have 'Domino Effect'

    Science.gov (United States)

    ... https://medlineplus.gov/news/fullstory_162758.html On Hospital Wards, Patient Crises May Have 'Domino Effect' When ... should serve as a wake-up call for hospital-based physicians," study author Dr. Matthew Churpek, an ...

  9. Demonic dominoes

    CERN Document Server

    Larham, Ron

    2013-01-01

    In response to a challenge in a recent paper to measure the propagation speed of the wave of collapse of an array of dominoes (the Domino Effect), a novel method of measuring the speed of such waves has been developed using sound recordings of the collapse and DEMON (Detection of Modulation on Noise) analysis to extract the frequency of domino impacts and hence the speed of propagation of the domino wave. This paper presents this method and a discussion of the other published measurements and models and some comments on the precess of mathematical modelling.

  10. Validation of a Model of the Domino Effect?

    CERN Document Server

    Larham, Ron

    2008-01-01

    A recent paper proposing a model of the limiting speed of the domino effect is discussed with reference to its need and the need of models in general for validation against experimental data. It is shown that the proposed model diverges significantly from experimentally derived speed estimates over a significant range of domino spacing using data from the existing literature and this author's own measurements, hence if its use had had economic importance its use outside its range of validity could have led to loses of one sort or another to its users.

  11. Contagion as Domino Effect in Global Stock Markets

    NARCIS (Netherlands)

    T.D. Markwat (Thijs); H.J.W.G. Kole (Erik); D.J.C. van Dijk (Dick)

    2008-01-01

    textabstractThis paper shows that stock market contagion operates through a domino effect, where small crashes evolve into more severe crashes. Using a novel unifying framework we model the occurrence of local, regional and global crashes in terms of past occurrences of these different crashes and f

  12. Risk management of domino effects considering dynamic consequence analysis.

    Science.gov (United States)

    Khakzad, Nima; Khan, Faisal; Amyotte, Paul; Cozzani, Valerio

    2014-06-01

    Domino effects are low-probability high-consequence accidents causing severe damage to humans, process plants, and the environment. Because domino effects affect large areas and are difficult to control, preventive safety measures have been given priority over mitigative measures. As a result, safety distances and safety inventories have been used as preventive safety measures to reduce the escalation probability of domino effects. However, these safety measures are usually designed considering static accident scenarios. In this study, we show that compared to a static worst-case accident analysis, a dynamic consequence analysis provides a more rational approach for risk assessment and management of domino effects. This study also presents the application of Bayesian networks and conflict analysis to risk-based allocation of chemical inventories to minimize the consequences and thus to reduce the escalation probability. It emphasizes the risk management of chemical inventories as an inherent safety measure, particularly in existing process plants where the applicability of other safety measures such as safety distances is limited. © 2013 Society for Risk Analysis.

  13. Contagion as Domino Effect in Global Stock Markets

    NARCIS (Netherlands)

    T.D. Markwat (Thijs); H.J.W.G. Kole (Erik); D.J.C. van Dijk (Dick)

    2008-01-01

    textabstractThis paper shows that stock market contagion operates through a domino effect, where small crashes evolve into more severe crashes. Using a novel unifying framework we model the occurrence of local, regional and global crashes in terms of past occurrences of these different crashes and

  14. What Do Children Learn by Trying to Produce the Domino Effect?

    Science.gov (United States)

    Ozaki, Kyoko; Yamamoto, Naoko; Kamii, Constance

    2008-01-01

    Preschool teachers use the domino effect--standing dominos on end in rows and pushing one over--to examine how play contributes to children's acquisition of knowledge. Using diagrams, photos, and vignettes of children between the ages of 3 and 5 years, the authors demonstrate how children at different stages of development use physical knowledge…

  15. What Do Children Learn by Trying to Produce the Domino Effect?

    Science.gov (United States)

    Ozaki, Kyoko; Yamamoto, Naoko; Kamii, Constance

    2008-01-01

    Preschool teachers use the domino effect--standing dominos on end in rows and pushing one over--to examine how play contributes to children's acquisition of knowledge. Using diagrams, photos, and vignettes of children between the ages of 3 and 5 years, the authors demonstrate how children at different stages of development use physical knowledge…

  16. Domino effects induced from rockfalls on industrial plants, Brescia, Italy

    Science.gov (United States)

    Lari, Serena; Frattini, Paolo; Battista Crosta, Giovanni; Agliardi, Federico; Buldrini, Marco; Oliveri, Stefano; Seminati, Paolo; Pozza, Francesco

    2010-05-01

    blocks impacting each industrial plant is obtained. The triggering of an accident caused by rockfall is assumed to occur when the modelled kinetic energy exceeds a critical threshold value. For each plant, the accident scenarios were defined based on existing External Emergency Plans. Both scenarios for fire and flash fire have been considered. The analysis shows the societal and economic risks due to domino effects of rockfalls on industrial plants are not negligible.

  17. The Domino Effects of Federal Research Funding.

    Science.gov (United States)

    Lanahan, Lauren; Graddy-Reed, Alexandra; Feldman, Maryann P

    2016-01-01

    The extent to which federal investment in research crowds out or decreases incentives for investment from other funding sources remains an open question. Scholarship on research funding has focused on the relationship between federal and industry or, more comprehensively, non-federal funding without disentangling the other sources of research support that include nonprofit organizations and state and local governments. This paper extends our understanding of academic research support by considering the relationships between federal and non-federal funding sources provided by the National Science Foundation Higher Education Research and Development Survey. We examine whether federal research investment serves as a complement or substitute for state and local government, nonprofit, and industry research investment using the population of research-active academic science fields at U.S. doctoral granting institutions. We use a system of two equations that instruments with prior levels of both federal and non-federal funding sources and accounts for time-invariant academic institution-field effects through first differencing. We estimate that a 1% increase in federal research funding is associated with a 0.411% increase in nonprofit research funding, a 0.217% increase in state and local research funding, and a 0.468% increase in industry research funding, respectively. Results indicate that federal funding plays a fundamental role in inducing complementary investments from other funding sources, with impacts varying across academic division, research capacity, and institutional control.

  18. The Domino Effects of Federal Research Funding.

    Directory of Open Access Journals (Sweden)

    Lauren Lanahan

    Full Text Available The extent to which federal investment in research crowds out or decreases incentives for investment from other funding sources remains an open question. Scholarship on research funding has focused on the relationship between federal and industry or, more comprehensively, non-federal funding without disentangling the other sources of research support that include nonprofit organizations and state and local governments. This paper extends our understanding of academic research support by considering the relationships between federal and non-federal funding sources provided by the National Science Foundation Higher Education Research and Development Survey. We examine whether federal research investment serves as a complement or substitute for state and local government, nonprofit, and industry research investment using the population of research-active academic science fields at U.S. doctoral granting institutions. We use a system of two equations that instruments with prior levels of both federal and non-federal funding sources and accounts for time-invariant academic institution-field effects through first differencing. We estimate that a 1% increase in federal research funding is associated with a 0.411% increase in nonprofit research funding, a 0.217% increase in state and local research funding, and a 0.468% increase in industry research funding, respectively. Results indicate that federal funding plays a fundamental role in inducing complementary investments from other funding sources, with impacts varying across academic division, research capacity, and institutional control.

  19. Prevention of domino effect: from active and passive strategies to inherently safer design.

    Science.gov (United States)

    Cozzani, Valerio; Tugnoli, Alessandro; Salzano, Ernesto

    2007-01-10

    The possible application of an inherent safety approach to the prevention of domino accidents was explored. The application of the inherent safety guidewords to the definition of effective actions for the prevention of domino events was analyzed. Due to the constraints originated by the conventional approach to process design, the "limitation of effects" guideword resulted the more effective in the identification of inherent safety actions to avoid domino events. Detailed design criteria for the improvement of layout in the framework of inherent safety were identified and discussed. Simple rules of thumbs were obtained for the preliminary assessment of safety distances and of critical inventories with respect to the escalation of fires and explosions. The results evidenced that the integration of inherent safety criteria with conventional passive or active protections seems a promising route for the prevention of severe domino accidental scenarios in chemical and process plants.

  20. Application of Graph Theory to Cost-Effective Fire Protection of Chemical Plants During Domino Effects.

    Science.gov (United States)

    Khakzad, Nima; Landucci, Gabriele; Reniers, Genserik

    2017-09-01

    In the present study, we have introduced a methodology based on graph theory and multicriteria decision analysis for cost-effective fire protection of chemical plants subject to fire-induced domino effects. By modeling domino effects in chemical plants as a directed graph, the graph centrality measures such as out-closeness and betweenness scores can be used to identify the installations playing a key role in initiating and propagating potential domino effects. It is demonstrated that active fire protection of installations with the highest out-closeness score and passive fire protection of installations with the highest betweenness score are the most effective strategies for reducing the vulnerability of chemical plants to fire-induced domino effects. We have employed a dynamic graph analysis to investigate the impact of both the availability and the degradation of fire protection measures over time on the vulnerability of chemical plants. The results obtained from the graph analysis can further be prioritized using multicriteria decision analysis techniques such as the method of reference point to find the most cost-effective fire protection strategy. © 2016 Society for Risk Analysis.

  1. The Domino Effect: Problem Solving with Common Table Games.

    Science.gov (United States)

    Reimer, Wilbert

    1989-01-01

    Domino games are used to illustrate problem-solving techniques in a college principles-of-mathematics course. Students develop tables and use Pascal's triangle to find the total number of pips and the sum of numbers on the pieces. (DC)

  2. The Domino Effect: Problem Solving with Common Table Games.

    Science.gov (United States)

    Reimer, Wilbert

    1989-01-01

    Domino games are used to illustrate problem-solving techniques in a college principles-of-mathematics course. Students develop tables and use Pascal's triangle to find the total number of pips and the sum of numbers on the pieces. (DC)

  3. A study on domino effect in nuclear fuel cycle facilities; Um estudo sobre o efeito domino em instalacoes do ciclo do combustivel nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Bozzolan, Jean-Claude

    2006-07-01

    Accidents caused by domino effect are among the most severe accidents in the chemical and process industry. Although the destructive potential of these accidental scenarios is widely known, little attention has been paid to this problem in the technical literature and a complete methodology for quantitative assessment of domino accidents contribution to industrial risk is still lacking. The present study proposed a systematic procedure for the quantitative assessment of the risk caused by domino effect in chemical plants that are part of nuclear fuel cycle plants. This work is based on recent advances in the modeling of fire and explosion damage to process equipment due to different escalation vectors (heat radiation, overpressure and fragment projection). Available data from literature and specific vulnerability models derived for several categories of process equipment had been used in the present work. The proposed procedure is applied to a typical storage area of a reconversion plant situated in a complex that shelters other nuclear fuel cycle facilities. The top-events and escalation vectors are identified, their consequences estimated and credible domino scenarios selected on the basis of their frequencies. (author)

  4. Gallium Arsenide Domino Circuit

    Science.gov (United States)

    Yang, Long; Long, Stephen I.

    1990-01-01

    Advantages include reduced power and high speed. Experimental gallium arsenide field-effect-transistor (FET) domino circuit replicated in large numbers for use in dynamic-logic systems. Name of circuit denotes mode of operation, which logic signals propagate from each stage to next when successive stages operated at slightly staggered clock cycles, in manner reminiscent of dominoes falling in a row. Building block of domino circuit includes input, inverter, and level-shifting substages. Combinational logic executed in input substage. During low half of clock cycle, result of logic operation transmitted to following stage.

  5. Domino instability effect of surrounding rock-coal pillars in a room-and-pillar gob

    Institute of Scientific and Technical Information of China (English)

    Li Chong; Xu Jinhai; Wang Zhongliang; Qin Shuai

    2013-01-01

    To discuss the domino instability effect and large area roof falling and roof accidents of surrounding rock-coal pillars in a room-and-pillar gob, the equilibrium equation for a roof-coal pillar-floor system with the influence of mining floor was developed based on the engineering conditions of the surrounding rock in a room-and-pillar gob in the 3-2 coal seam of Tanggonggou mine. The conditions of system instability and the relationship between system stability and system stiffness were analyzed from an energetic point of view. Numerical simulation using the discrete element software UDEC was also carried out to simulate conditions causing the domino effect on surrounding rock-coal pillars in a 3-2 room-and-pillar gob. The results show that:if we want the system to destabilize, the collective energy in roof-and-floor must be larger than that in the coal pillar. When the stiffness of the coal pillars and the roof-and-floor are both greater than zero, the system is stable. When the stiffness of the coal pillars is negative but the summed stiffness of the coal pillars and roof-and-floor is larger than or equal to zero, the system is statically destroyed. When the sum of the coal pillars and the roof-floor stiffness is negative, the system suffers from severe damages. For equal advance distances of the coal mining face, the wider coal pillars can reduce the probability of domino type instability. Conversely, the smaller width pillars can increase the instability probability. Domino type instability of surrounding rock-coal pillars is predicted to be unli-kely when the width of coal pillars is not less than 8 m.

  6. Risk-based design of process plants with regard to domino effects and land use planning

    Energy Technology Data Exchange (ETDEWEB)

    Khakzad, Nima, E-mail: nkhakzad@gmail.com [Safety and Security Science Group (S3G), Faculty of Technology, Policy and Management, TU Delft, Delft (Netherlands); Reniers, Genserik [Safety and Security Science Group (S3G), Faculty of Technology, Policy and Management, TU Delft, Delft (Netherlands); Antwerp Research Group on Safety and Security (ARGoSS), Faculty of Applied Economics, Universiteit Antwerpen, Antwerp (Belgium); Research Group CEDON, Campus Brussels, KULeuven, Brussels (Belgium)

    2015-12-15

    Highlights: • A Bayesian network methodology has been developed to estimate the total probability of major accidents in chemical plants. • Total probability of accidents includes the probability of individual accidents and potential domino effects. • The methodology has been extended to calculate on-site and off-site risks. • The results of the risk analysis have been used in a multi-criteria decision analysis technique to risk-based design of chemical plants. - Abstract: Land use planning (LUP) as an effective and crucial safety measure has widely been employed by safety experts and decision makers to mitigate off-site risks posed by major accidents. Accordingly, the concept of LUP in chemical plants has traditionally been considered from two perspectives: (i) land developments around existing chemical plants considering potential off-site risks posed by major accidents and (ii) development of existing chemical plants considering nearby land developments and the level of additional off-site risks the land developments would be exposed to. However, the attempts made to design chemical plants with regard to LUP requirements have been few, most of which have neglected the role of domino effects in risk analysis of major accidents. To overcome the limitations of previous work, first, we developed a Bayesian network methodology to calculate both on-site and off-site risks of major accidents while taking domino effects into account. Second, we combined the results of risk analysis with Analytic Hierarchical Process to design an optimal layout for which the levels of on-site and off-site risks would be minimum.

  7. An improved probit method for assessment of domino effect to chemical process equipment caused by overpressure.

    Science.gov (United States)

    Mingguang, Zhang; Juncheng, Jiang

    2008-10-30

    Overpressure is one important cause of domino effect in accidents of chemical process equipments. Damage probability and relative threshold value are two necessary parameters in QRA of this phenomenon. Some simple models had been proposed based on scarce data or oversimplified assumption. Hence, more data about damage to chemical process equipments were gathered and analyzed, a quantitative relationship between damage probability and damage degrees of equipment was built, and reliable probit models were developed associated to specific category of chemical process equipments. Finally, the improvements of present models were evidenced through comparison with other models in literatures, taking into account such parameters: consistency between models and data, depth of quantitativeness in QRA.

  8. Risk-based design of process plants with regard to domino effects and land use planning.

    Science.gov (United States)

    Khakzad, Nima; Reniers, Genserik

    2015-12-15

    Land use planning (LUP) as an effective and crucial safety measure has widely been employed by safety experts and decision makers to mitigate off-site risks posed by major accidents. Accordingly, the concept of LUP in chemical plants has traditionally been considered from two perspectives: (i) land developments around existing chemical plants considering potential off-site risks posed by major accidents and (ii) development of existing chemical plants considering nearby land developments and the level of additional off-site risks the land developments would be exposed to. However, the attempts made to design chemical plants with regard to LUP requirements have been few, most of which have neglected the role of domino effects in risk analysis of major accidents. To overcome the limitations of previous work, first, we developed a Bayesian network methodology to calculate both on-site and off-site risks of major accidents while taking domino effects into account. Second, we combined the results of risk analysis with Analytic Hierarchical Process to design an optimal layout for which the levels of on-site and off-site risks would be minimum. Copyright © 2015 Elsevier B.V. All rights reserved.

  9. Repeatable timing of northward departure, arrival and breeding in Black-tailed Godwits Limosa l. limosa, but no domino effects

    NARCIS (Netherlands)

    Lourenco, Pedro M.; Kentie, Rosemarie; Schroeder, Julia; Groen, Niko M.; Piersma, Theunis; Bairlein, F.; Hooijmeijer, Jos C.E.W.

    2011-01-01

    When early breeding is advantageous, migrants underway to the breeding areas may be time stressed. The timing of sequential events such as migration and breeding is expected to be correlated because of a "domino effect", and would be of particular biological importance if timings are repeatable

  10. Domino Effect

    Science.gov (United States)

    Carrell, Scott E.; Hoekstra, Mark L.

    2009-01-01

    Each year, between 10 and 20 percent of schoolchildren in the United States are exposed to domestic violence. According to psychologists, such exposure can lead to aggressive behavior, decreased social competence, and diminished academic performance. A majority of parents and school officials believe that children who are troubled, whatever the…

  11. Domino Effect

    Science.gov (United States)

    Carrell, Scott E.; Hoekstra, Mark L.

    2009-01-01

    Each year, between 10 and 20 percent of schoolchildren in the United States are exposed to domestic violence. According to psychologists, such exposure can lead to aggressive behavior, decreased social competence, and diminished academic performance. A majority of parents and school officials believe that children who are troubled, whatever the…

  12. Saturated Domino Coverings

    CERN Document Server

    Buchanan, Andrew; Ryba, Alex

    2011-01-01

    A domino covering of a board is saturated if no domino is redundant. We introduce the concept of a fragment tiling and show that a minimal fragment tiling always corresponds to a maximal saturated domino covering. The size of a minimal fragment tiling is the domination number of the board. We define a class of regular boards and show that for these boards the domination number gives the size of a minimal X-pentomino covering. Natural sequences that count maximal saturated domino coverings of square and rectangular boards are obtained. These include the new sequences A193764, A193765, A193766, A193767, and A193768 of OEIS.

  13. A Near-Infrared Triggered Nanophotosensitizer Inducing Domino Effect on Mitochondrial Reactive Oxygen Species Burst for Cancer Therapy.

    Science.gov (United States)

    Yu, Zhengze; Sun, Qiaoqiao; Pan, Wei; Li, Na; Tang, Bo

    2015-11-24

    Photodynamic therapy (PDT) is a well-established modality for cancer therapy, which locally kills cancer cells when light irradiates a photosensitizer. However, conventional PDT is often limited by the extremely short lifespan and severely limited diffusion distance of reactive oxygen species (ROS) generated by photosensitizer, as well as the penetration depth of visible light activation. Here, we develop a near-infrared (NIR) triggered nanophotosensitizer based on mitochondria targeted titanium dioxide-coated upconversion nanoparticles for PDT against cancer. When irradiated by NIR laser, the nanophotosensitizer could produce ROS in mitochondria, which induced the domino effect on ROS burst. The overproduced ROS accumulated in mitochondria, resulting in mitochondrial collapse and irreversible cell apoptosis. Confocal fluorescence imaging indicated that the mitochondrial targeting and real-time imaging of ROS burst could be achieved in living cells. The complete removal of tumor in vivo confirmed the excellent therapeutic effect of the nanophotosensitizer.

  14. Stimulating Mathematical Thinking through Domino Games

    Science.gov (United States)

    Gough, John

    2015-01-01

    Most readers would be familiar with the standard domino set which is played with rectangular domino tiles. The domino set, sometimes called a deck or pack, consists of 28 dominoes, colloquially nicknamed bones, cards, tiles, stones, or spinners. A domino set is a generic gaming device, similar to playing cards or dice, in that a variety of games…

  15. Stimulating Mathematical Thinking through Domino Games

    Science.gov (United States)

    Gough, John

    2015-01-01

    Most readers would be familiar with the standard domino set which is played with rectangular domino tiles. The domino set, sometimes called a deck or pack, consists of 28 dominoes, colloquially nicknamed bones, cards, tiles, stones, or spinners. A domino set is a generic gaming device, similar to playing cards or dice, in that a variety of games…

  16. 石油库储罐区池火灾多米诺效应研究%Domino Effect Caused by Pool Fire in Petroleum Storage Tank District

    Institute of Scientific and Technical Information of China (English)

    臧娜

    2011-01-01

    依据多米诺效应的特点,从多米诺效应发生的机制,阐述了石油库储罐区池火灾多米诺效应的分析过程.首先辨识石油库储罐区多米诺效应的事故场景,针对场景的复杂性和事故后果的严重性,运用烃类池火灾事故后果定量分析模型和概率分析对池火灾事故场景进行分析;然后根据初始事故的影响,运用设备损坏概率模型计算二次目标设备的损坏概率和场景后果;最后结合具体实例对石油库储罐区池火灾进行多米诺效应分析.通过石油库储罐区池火灾事故多米诺效应评价,得出石油库储罐区事故的升级因素和导致事故扩大的途径,并指出相应的多米诺效应控制措施,从而可以有针对性地采取相应的预防措施,预防池火灾事故多米诺效应,降低次生灾害的发生率.提高石油库储罐区的本质安全,为现行的优化提供科学的依据.%This paper presents a study ot Domino effects, including the mechanism and characteristics. The Domino effect is a complex phenomenon, in which severe accidents may take place in chains. For example, in a petroleum storage tank, one accident may cause a secondary accident in other facility nearby. In this paper, the mathematieal models of pool fire and the probability analysis are used for the assessment, incduding the vulnerability assessment of the consequence. The risk of the Domino effect is determined by using the quantitative risk analyses technique suggested in this paper. The probabilities of Domimo events and their consequences are calculated. A systematic procedure for the quanlitative assessmenl of risk caused by Domino effects is proposed for the risk analysis of petroleum storage pool fire accidents. The factors and the manners of the propagation and enhancement of the accident are. analyzed by assessing the risk caused by Domino effect of pool fire. Safety measures to avoid Domino effect is thus suggested. This method can predict the

  17. The Effect of a Numerical Domino Game on Numerical Magnitude Processing in Children with Mild Intellectual Disabilities

    Science.gov (United States)

    Brankaer, Carmen; Ghesquière, Pol; De Smedt, Bert

    2015-01-01

    Children with mild intellectual disabilities (MID) appear to have particular problems in understanding the numerical meaning of Arabic digits. Therefore, we developed and evaluated a numerical domino game that specifically targeted the association between these digits and the numerical magnitudes they represent. Participants were 30 children with…

  18. The Effect of a Numerical Domino Game on Numerical Magnitude Processing in Children with Mild Intellectual Disabilities

    Science.gov (United States)

    Brankaer, Carmen; Ghesquière, Pol; De Smedt, Bert

    2015-01-01

    Children with mild intellectual disabilities (MID) appear to have particular problems in understanding the numerical meaning of Arabic digits. Therefore, we developed and evaluated a numerical domino game that specifically targeted the association between these digits and the numerical magnitudes they represent. Participants were 30 children with…

  19. Gold-catalyzed domino reactions.

    Science.gov (United States)

    Michelet, Véronique

    2015-01-01

    Gold-catalyzed reactions have appeared to be highly attractive tools for chemists to promote novel transformations to prepare elaborated structures from simple starting materials. This chapter presents selected and original examples of domino processes in the presence of gold catalysts, highlighting reports implying hydration, hydroxylation, and hydroamination as key starting point for cascade transformations. Domino processes implying 1,n-enynes, asymmetric domino transformations, and applications of all the presented processes in total synthesis are presented.

  20. Domino heart transplantation: long-term outcome of recipients and their living donors: single center experience.

    Science.gov (United States)

    Raffa, G M; Pellegrini, C; Viganò, M

    2010-11-01

    "Domino" cardiac procedure is an effective option to increase the donor pool when heart-lung transplantation (HLT) is the only treatment for patients with terminal cardiopneumopathy. We reviewed the long-term outcomes of domino cardiac donors and recipients at our institution. Ten of 35 patients who underwent HLT from 1991 onward served as domino cardiac donors. They included eight female and two male subjects of overall mean age of 33 years and mean weight of 55 kg. Their diagnoses were primary pulmonary hypertension (n = 6) as well as cystic fibrosis, bronchiectasis, Eisenmenger's syndrome, and bronchiolitis obliterans (n = 1 each). The domino cardiac recipients included six males and four females of overall mean age of 47 years and mean weight of 61 kg. They were affected by ischemic heart disease (n = 5), cardiomyopathy (n = 4), and valvular heart disease (n = 1). Mean pulmonary vascular resistance was 3 Wood units. The heart was used either in the orthotopic (n = 8) or in the heterotopic position (n = 2). The 1-, 5-, and 10-year survivals for the domino cardiac donors versus their recipients were 60%, 40%, 30% versus 90%, 70%, 60%, respectively. Five domino donors developed bronchiolitis obliterans syndrome. Among the domino recipients group, cardiac allograft vasculopathy was rare (n = 1). Common causes of late death were in the domino recipients infections in the domino donors (n = 2) and malignancies. Our experience suggested good long-term results of the domino procedure. Copyright © 2010 Elsevier Inc. All rights reserved.

  1. Monte Carlo analysis of a low power domino gate under parameter fluctuation

    Institute of Scientific and Technical Information of China (English)

    Wang Jinhui; Wu Wuchen; Gong Na; Hou Ligang; Peng Xiaohong; Gao Daming

    2009-01-01

    Using the multiple-parameter Monte Carlo method, the effectiveness of the dual threshold voltage technique (DTV) in low power domino logic design is analyzed. Simulation results indicate that under significant temperature and process fluctuations, DTV is still highly effective in reducing the total leakage and active power consumption for domino gates with speed loss. Also, regarding power and delay characteristics, different structure domino gates with DTV have different robustness against temperature and process fluctuation.

  2. Monte Carlo analysis of a low power domino gate under parameter fluctuation

    Energy Technology Data Exchange (ETDEWEB)

    Wang Jinhui; Wu Wuchen; Hou Ligang; Peng Xiaohong; Gao Daming [VLSI and System Laboratory, Beijing University of Technology, Beijing 100124 (China); Gong Na, E-mail: wangjinhui888@emails.bjut.edu.c [Department of Computer Science and Engineering, State University of New York at Buffalo, Buffalo 14260, NY (United States)

    2009-12-15

    Using the multiple-parameter Monte Carlo method, the effectiveness of the dual threshold voltage technique (DTV) in low power domino logic design is analyzed. Simulation results indicate that under significant temperature and process fluctuations, DTV is still highly effective in reducing the total leakage and active power consumption for domino gates with speed loss. Also, regarding power and delay characteristics, different structure domino gates with DTV have different robustness against temperature and process fluctuation. (semiconductor integrated circuits)

  3. Domino liver graft from a patient with homozygous familial hypercholesterolemia.

    Science.gov (United States)

    Liu, Chinsu; Niu, Dau-Ming; Loong, Che-Chuan; Hsia, Cheng-Yuan; Tsou, Mei-Yung; Tsai, Hsin-Lin; Wei, Choufu

    2010-05-01

    HFH is a metabolic disease caused by a defect in the gene that encodes the synthesis of the cellular receptor for LDL-Rs. A high plasma level of cholesterol is present from birth and leads to severe atherosclerosis in childhood, and death from myocardial infarction usually occurs before the age of 20 yr. The liver contains approximately 50-75% of the total body LDL-Rs; therefore, liver transplantation has been carried out to treat this metabolic disorder effectively. The rationale for using an HFH liver for a domino graft is that the absence of functional LDL-Rs in the liver may be compensated for by the extra-hepatic LDL-Rs. Therefore, an HFH liver can possibly be used as a domino graft for a recipient with a normal plasma cholesterol level before transplantation. We herein report a domino liver transplantation using an HFH liver as a domino graft with successful results. To expand the donor pool, especially in Asian countries, domino grafts from HFH should be encouraged by careful selection of the domino recipient.

  4. 储罐区火灾引发多米诺效应的概率分析方法%Probability Analysis for Domino Effect Triggered by Storage Tank Fire

    Institute of Scientific and Technical Information of China (English)

    周剑峰

    2015-01-01

    石化工业储罐区储存大量易燃物质,储罐发生火灾可能对邻近储罐造成影响,引发严重的多米诺事故。火灾发生后的应急响应会对事故发展造成影响,并影响多米诺效应的发生概率。结合Probit分析方法和我国火灾应急响应统计数据,建立了储罐区火灾引发多米诺效应的概率分析模型,并以汽油储罐火灾为例,分析了多米诺效应的概率。%In petrochemical industry ,large quantities of different flammable substances are stored in tank areas .Due to mutual impacts among the tanks ,severe domino accidents may occur after a tank catches fire .The emergency response to a tank fire may influence the development of the accident and impact on the occurring likelihood of domino effects .Based on the Probit method for assessing domino effect triggered by fire and the statistical emergency response data of our country ,the probability assessment model for domino effect triggered by tank fire is proposed .Tank fire among gasoline storage tanks is taken as an example to illustrate this approach .

  5. Heat flux modulation in domino dynamo model

    CERN Document Server

    Reshetnyak, Maxim

    2012-01-01

    Using domino dynamo model we show how variations of the heat flux at the core-mantle boundary change frequency of geomagnetic field reversals. In fact, we are able to demonstrate effect known from the modern 3D planetary dynamo models using ensemble of the interacting spins, which obey equations of the Langevin-type with a random force. We also consider applications to the giant- planets and offer explanations of some specific episodes of the geomagnetic field in the past.

  6. Domino effect of hypomagnesemia on the innate immunity of Crohn’s disease patients

    Institute of Scientific and Technical Information of China (English)

    Saleh; A; Naser; Almatmed; Abdelsalam; Saisathya; Thanigachalam; Abed; S; Naser; Karel; Alcedo

    2014-01-01

    Digestive diseases play major role in development and complications of other disorders including diabetes.For example,Crohn’s disease(CD)is an inflammatory bowel disease associated with Mycobacterium avium subspecies paratuberculosis.The inflammation is a complex process that involves the activity of both innate and adaptive immune responses.CD lesions are primarily due to T cell response,however;innate immune response has a significant role in initiating its pathogenesis.Toll-like receptors and NOD-like receptors promote the activity of nuclear factor(NF)-κB pathway for cytokines production.This results in the production of high levels of tumor necrosis factor-α,interleukin(IL)-1βand IL-6.Moreover,intestinal inflammation of CD is related to increased activity of NMDA receptors and the release of substance P.Imbalanced magnesium homeostasis in CD is a frequent finding in CD,Diabetes and others.The loss of such a major mineral affects many physiological processes in the body including its role as an immunomodulator.This review aims to(1)describe the significance of hypomagnesemia in the release of pro-inflammatory mediators in CD;(2)demonstrate effects of magnesium on pathways like NF-κB;(3)address the role of hypomagnesemia in the activity of CD;and(4)examine possible future research to establish a standard magnesium supplementation strategy;helping patients with CD or other disorders to maintain a sustained remission.

  7. Finite Random Domino Automaton

    CERN Document Server

    Bialecki, Mariusz

    2012-01-01

    Finite version of Random Domino Automaton (FRDA) - recently proposed a toy model of earthquakes - is investigated. Respective set of equations describing stationary state of the FRDA is derived and compared with infinite case. It is shown that for the system of big size, these equations are coincident with RDA equations. We demonstrate a non-existence of exact equations for size N bigger then 4 and propose appropriate approximations, the quality of which is studied in examples obtained within Markov chains framework. We derive several exact formulas describing properties of the automaton, including time aspects. In particular, a way to achieve a quasi-periodic like behaviour of RDA is presented. Thus, based on the same microscopic rule - which produces exponential and inverse-power like distributions - we extend applicability of the model to quasi-periodic phenomena.

  8. Playing with Dominoes: Proof by Induction

    Science.gov (United States)

    Kaplan, Gail

    2009-01-01

    This article describes a hands-on approach to learning proofs by induction. Students create patterns of dominos so that when the first domino is pushed, the entire design collapses, one domino at a time. Students then build designs that do not work. By constructing a list of conditions that ensure a given pattern will collapse, students discover…

  9. Playing with Dominoes: Proof by Induction

    Science.gov (United States)

    Kaplan, Gail

    2009-01-01

    This article describes a hands-on approach to learning proofs by induction. Students create patterns of dominos so that when the first domino is pushed, the entire design collapses, one domino at a time. Students then build designs that do not work. By constructing a list of conditions that ensure a given pattern will collapse, students discover…

  10. Research on quantitative risk assessment in chemical park based on domino effect model%基于多米诺效应的化工园区定量风险评估方法研究

    Institute of Scientific and Technical Information of China (English)

    马科伟; 朱建新; 包士毅

    2011-01-01

    In order to quantitatively assess the risk of chemical park, a domino-based model was introduced for modeling the domino-caused risks. The definition, characteristics and mechanism of domino effect were introduced in this model. The probability of damages and human vulnerabilities caused by different primary hazardous events was also proposed and then used for the quantitative assessment of both individual and societal risks created by the chemical park. The individual and societal risks (F N curve), together with associated quantitative methods were also involved. It was found that, by applying the method in real case, the risk caused by domino effect can be dramatically increased. This finding would be beneficial to the safety planning and risk management of chemical parks.%探讨了多米诺效应的定义,特点及其发生机理,对基于多米诺效应的定量风险评估方法进行了研究.针对不同初始事件的物理效应因素给出了目标设备损害几率的计算方法,运用人体损伤模型对事故后果进行定量分析,量化了风险,给出个人风险图和F-N社会风险曲线.实例计算表明:多米诺效应明显扩大了事故风险.通过多米诺效应分析有利于园区的安全规划和管理.

  11. 基于贝叶斯概率的油库池火灾多米诺效应分析%Analysis on pool fire Domino effect in fuel tank district based on Bayes probability

    Institute of Scientific and Technical Information of China (English)

    张青松; 杨一楠; 郑薇

    2013-01-01

    The present paper is dedicated to a study of the pool fire Domino effect in fuel tank district based on Bayes probability theory.In order to prevent the pool fire Domino effect,we have attempted to bring the Bayes theory into the analysis of the effect in hoping to quantify the probability of such a kind of Domino effect.For this purpose,we have established a novel Bayes model of pool fire Domino effect in fuel tank district with the basic performance steps proposed.First of all,we have chosen the first accident as the parent node of the Bayes net and then analyzed the radiation path of the pool fire Domino effect so as to confirm all the other accidents of the pool fire Domino effect.Having performed the above 3 steps of Bayes net reasoning principle,it would be easier to accomplish Bayes net chart according to all the different final accidents.Besides,step (5) should be the fulfillment of the condition probability table,in which the prior probabilities can be worked out with the adoption of equipment damage probability model.Based on the fulfillment of the prior probabilities,we have worked out all the posterior probabilities of all the accident scenarios with the biggest posterior probability ascertained.The last step is to control the measuring institution on the basis of reassuring the best control point to the accident and the logic features of the accident links.Combined with a typical example,we have confirmed the posterior probability that perpetrates the biggest contribution to the pool fire Domino effect through the application of Bayes model in fuel tank district.And,consequently,we have managed to improve the control measure in accordance with the energy transfer sequence of the relative accident links.%将贝叶斯理论引入油库池火灾多米诺效应分析中,建立油库池火灾多米诺效应的贝叶斯模型并给出建模的基本步骤,推理得出油库池火灾多米诺效应的事故场景,提出基于池火灾多米诺效应的贝叶

  12. Robustness aware high performance high fan-in domino OR logic design

    Institute of Scientific and Technical Information of China (English)

    Gong Na; Wang Jinhui; Guo Baozeng; Wang Yongqing; Cao Xiaobing; Tian Xiuli

    2009-01-01

    A novel technique using a keeper with a simultaneous low supply voltage and low body voltage is proposed to improve the overall performance of high fan-in OR gates without modifying the physical dimensions of the keeper. Simulation results of a 16-input domino OR gate using 45 nm CMOS technology show that the proposed technique could trade off between a high power/speed efficient operation and the robustness to noise effectively.Also, a Monte Carlo analysis indicates that the proposed domino OR gate is more robust to parameter variation compared to a conventional domino OR gate.

  13. Environmental external effects from wind power based on the EU ExternE methodology

    DEFF Research Database (Denmark)

    Ibsen, Liselotte Schleisner; Nielsen, Per Sieverts

    1998-01-01

    The European Commission has launched a major study project, ExternE, to develop a methodology to quantify externalities. A “National Implementation Phase”, was started under the Joule II programme with the purpose of implementing the ExternE methodology in all member states. The main objective...

  14. Copper-Catalyzed Multicomponent Domino Reaction of 2-Bromoaldehydes, Benzylamines, and Sodium Azide for the Assembly of Quinazoline Derivatives.

    Science.gov (United States)

    Xu, Cheng; Jia, Feng-Cheng; Zhou, Zhi-Wen; Zheng, Si-Jie; Li, Han; Wu, An-Xin

    2016-04-01

    An efficient three-component domino reaction of 2-bromoaldehydes, benzylamines, and sodium azide has been developed for the synthesis of quinazoline derivatives. This domino process involves copper-catalyzed SNAr, oxidation/cyclization, and denitrogenation sequences. The mild catalytic system enabled the effective construction of three C-N bonds in one operation.

  15. Economics of tipping the climate dominoes

    Science.gov (United States)

    Lemoine, Derek; Traeger, Christian P.

    2016-05-01

    Greenhouse gas emissions can trigger irreversible regime shifts in the climate system, known as tipping points. Multiple tipping points affect each other’s probability of occurrence, potentially causing a `domino effect’. We analyse climate policy in the presence of a potential domino effect. We incorporate three different tipping points occurring at unknown thresholds into an integrated climate-economy model. The optimal emission policy considers all possible thresholds and the resulting interactions between tipping points, economic activity, and policy responses into the indefinite future. We quantify the cost of delaying optimal emission controls in the presence of uncertain tipping points and also the benefit of detecting when individual tipping points have been triggered. We show that the presence of these tipping points nearly doubles today’s optimal carbon tax and reduces peak warming along the optimal path by approximately 1 °C. The presence of these tipping points increases the cost of delaying optimal policy until mid-century by nearly 150%.

  16. Blast effects of external explosions

    OpenAIRE

    Sochet, Isabelle

    2010-01-01

    International audience; Security considerations for industrial production and storage require characterization of the mechanical effects caused by blast waves resulting from a detonation or deflagration. This paper evaluates current analytical methods to determine the characteristic parameters of a blast wave with respect to the pressure, impulse and duration of the positive phase of the blast. In the case of a detonation, the trinitrotoluene (TNT) equivalent-based method determines the mass ...

  17. Self-Immolative Chemiluminescence Polymers: Innate Assimilation of Chemiexcitation in a Domino-like Depolymerization.

    Science.gov (United States)

    Gnaim, Samer; Shabat, Doron

    2017-07-26

    Self-immolative polymers are distinctive materials able to disassemble in a domino-like mechanism from head-to-tail upon a triggering event induced by an external stimulus. We have developed an effective molecular method to intrinsically assimilate a chemiluminescence turn-ON mechanism with a domino-like fragmentation mechanism. A unique molecular unit was synthesized, which could combine the abilities of executing the duel function of quinone-methide elimination and chemiexcitation. Incorporation of this unit as a monomer, results with the first class of stimuli-responsive self-immolative polymers with amplified chemiluminescence output. Responsive groups for various analytes were introduced as a head-trigger during the polymer synthesis. The polymers were demonstrated as chemiluminescence probes for detection of different chemical analytes. The obtained polymers were able to amplify the intensity and the duration of the light emission signal by factors correlated to their length. We anticipate that the chemiluminescence self-immolative polymers described here will find use for various research topics such as signal amplification, light-emitting new materials, and molecular probes with long-lasting light emission and imaging capabilities.

  18. The ventilatory effect of external oscillation.

    Science.gov (United States)

    Isabey, D; Piquet, J

    1989-01-01

    High frequency ventilation (HFV) may be achieved by external oscillation (external HFV) applied around the chest wall (HFCWO) in large animals and humans, or over the entire body (HFBSO) in small animals, instead of being applied via the trachea (internal HFV). We present a synthesis of the results obtained with external HFV in both normal and bronchoconstricted subjects. Whereas external and internal HFV were found to be equivalent in terms of gas exchange in normal rats, external HFV was found to have a beneficial effect in bronchoconstricted rabbits, but internal HFV did not. From the frequency-oscillatory tidal volume relationship determined in normocapnic rabbits, HFBSO at 5 Hz was found to be the optimal frequency at which to ventilate with tidal volumes close to the dead space volume, and which was also shown to be the optimal volume to obtain normocapnia. Moreover, 5 Hz oscillations (HFCWO) at 20 ml and 40 ml superimposed on tidal breathing accelerated nitrogen washout, i.e., gas exchange in normal humans. Unfortunately, only oscillations with much smaller volumes (5-10 ml) were obtainable in COPD patients. Nevertheless, they produced a clear change in breathing pattern associated with a slight improvement in gas exchange and a potentially positive effect on inspiratory muscle fatigue. These results support the concept that non-invasive external HFV technique may be of use in assisting ventilation in bronchoconstricted subjects and may possibly replace conventional controlled ventilation, at least in subjects with high lung compliance, such as babies, neonates and normal adults.

  19. Motzkin numbers out of Random Domino Automaton

    CERN Document Server

    Białecki, Mariusz

    2011-01-01

    Motzkin numbers are derived from a special case of Random Domino Automaton - recently proposed toy model of earthquakes. An exact solution of the set of equations describing stationary state of Random Domino Automaton in "inverse-power" case is presented. A link with Motzkin numbers allows to present explicit form of asymptotic behaviour of the automaton.

  20. Catalytic Radical Domino Reactions in Organic Synthesis.

    Science.gov (United States)

    Sebren, Leanne J; Devery, James J; Stephenson, Corey R J

    2014-02-07

    Catalytic radical-based domino reactions represent important advances in synthetic organic chemistry. Their development benefits synthesis by providing atom- and step-economical methods to complex molecules. Intricate combinations of radical, cationic, anionic, oxidative/reductive, and transition metal mechanistic steps result in cyclizations, additions, fragmentations, ring-expansions, and rearrangements. This Perspective summarizes recent developments in the field of catalytic domino processes.

  1. Low Power Dynamic Logic Ripple Carry Adder Using Footed Diode Domino Logic

    Directory of Open Access Journals (Sweden)

    P. Krishna Karthik

    2014-03-01

    Full Text Available In recent electronic devices power saving has more importance than any other thing. Dynamic logic circuits are one of the basic power efficient circuits which comes into picture when dealt with low power. Dynamic logic circuits operate mainly in two phases, namely Pre-charge and evaluate phase. Domino logic circuits are more power efficient and cooperatively faster circuits which operate on the above two phases. For extremely low power applications footed diode domino logic is applied. This paper mainly deals with design of Dynamic logic circuit design based on footed diode domino logic with reduction in power and leakage current. In this proposed circuit we put a diode on the foot of domino logic circuit which results in power reduction as compared to reported and conventional domino logic. We are using NMOS as a diode and due to this extra diode (NMOS, in pre-charge period leakage current reduce due to stacking effect. Approximately 32% of power is saved using footed diode domino logic. For Simulation we are using tanner tool at 180nm technology.

  2. Position Auctions with Externalities and Brand Effects

    OpenAIRE

    Hummel, Patrick; McAfee, R. Preston

    2014-01-01

    This paper presents models for predicted click-through rates in position auctions that take into account two possibilities that are not normally considered---that the identities of ads shown in other positions may affect the probability that an ad in a particular position receives a click (externalities) and that some ads may be less adversely affected by being shown in a lower position than others (brand effects). We present a general axiomatic methodology for how click probabilities are aff...

  3. Catalytic Radical Domino Reactions in Organic Synthesis

    Science.gov (United States)

    Sebren, Leanne J.; Devery, James J.; Stephenson, Corey R.J.

    2014-01-01

    Catalytic radical-based domino reactions represent important advances in synthetic organic chemistry. Their development benefits synthesis by providing atom- and step-economical methods to complex molecules. Intricate combinations of radical, cationic, anionic, oxidative/reductive, and transition metal mechanistic steps result in cyclizations, additions, fragmentations, ring-expansions, and rearrangements. This Perspective summarizes recent developments in the field of catalytic domino processes. PMID:24587964

  4. Evaluation of domino liver transplantations in Germany.

    Science.gov (United States)

    Bolte, Fabian Johannes; Schmidt, Hartmut H-J; Becker, Thomas; Braun, Felix; Pascher, Andreas; Klempnauer, Jürgen; Schmidt, Jan; Nadalin, Silvio; Otto, Gerd; Barreiros, Ana Paula

    2013-07-01

    A retrospective multicenter study has been conducted to evaluate domino liver transplantations (DLTs) in Germany. The study provides insight into survival and features having an impact on the assessment of neuropathy after DLT. In addition, a neurologic follow-up program with a scheme to estimate the likelihood of de novo amyloidosis is presented. A series of 61 DLTs at seven transplant centers in Germany was enrolled. The mean age of domino recipients at the time of transplantation was 58 years, 46 of them being men, and 15 being women. The median follow-up was 46 months. The overall 1-, 3-, and 5-year survival of domino recipients was 81.6%, 70.8% and 68.8%, respectively. Causes of death were primarily not related to familial amyloidosis. The main indication of DLT was hepatocellular carcinoma. Two of the reported domino recipients developed symptoms and signs of de novo amyloidosis within 10 years after transplantation. A total of 30 domino graft recipients (49.18%) presented with diabetes post transplantation. In conclusion, an advanced follow-up program is crucial to evaluate the risk of transmitting familial amyloidosis by DLT and to establish more strict selection criteria for domino recipients. © 2013 Steunstichting ESOT. Published by John Wiley & Sons Ltd.

  5. domino effect的来历

    Institute of Scientific and Technical Information of China (English)

    杨华

    2008-01-01

    domino(多米诺骨牌)是西方人常玩的一种长方形骨牌,通常有骨制的,也有木制的。如果人们把许多张骨牌依次竖排成行,碰倒第一张,其余的牌也会一张张依次倒下。人们把这种现象称为domino phenomenon(多米诺现象)或domino effect(多米诺效应),并用它们比喻“连锁反应现象”。

  6. Observation of optical domino modes in arrays of non-resonant plasmonic nanoantennas

    Science.gov (United States)

    Sinev, Ivan S.; Samusev, Anton K.; Voroshilov, Pavel M.; Mukhin, Ivan S.; Denisyuk, Andrey I.; Guzhva, Mikhail E.; Belov, Pavel A.; Simovski, Constantin R.

    2014-09-01

    Domino modes are highly-confined collectivemodes that were first predicted for a periodic arrangement of metallic parallelepipeds in far-infrared region. The main feature of domino modes is the advantageous distribution of the local electric field, which is concentrated between metallic elements (hot spots), while its penetration depth in metal is much smaller than the skin-depth. Therefore, arrays of non-resonant plasmonic nanoantennas exhibiting domino modes can be employed as broadband light trapping coatings for thin-film solar cells. However, until now in the excitation of such modes was demonstrated only in numerical simulations. Here, we for the first time demonstrate experimentally the excitation of optical domino modes in arrays of non-resonant plasmonic nanoantennas. We characterize the nanoantenna arrays produced by means of electron beam lithography both experimentally using an aperture-type near-field scanning optical microscope and numerically. The proof of domino modes concept for plasmonic arrays of nanoantennas in the visible spectral region opens new pathways for development of low-absorptive structures for effective focusing of light at the nanoscale.

  7. Domino Reactions in Drug Design and Discovery.

    Science.gov (United States)

    Bhar, Shanta; Ramana, Mucheli M V

    2016-01-01

    With reference to challenges in developing varied and exceedingly complex scaffolds expeditiously through atom economy, domino reactions have assumed a significant role in several transformative endeavors towards established pharmaceuticals and new chemical entities across diverse therapeutic classes such as HIV integrase inhibitors, DPP4 [dipeptidyl peptidase IV] inhibitors, GSK- 3 (Glycogen Synthase Kinase 3) inhibitors, neoplastic drugs and microtubule antagonists. The very large chemical space of Domino Reactions can be leveraged for the design strategy of drugs and drug- like candidates with leading examples like Indinavir (Crixivan), Trandolapril (Mavik), Biyouyanagin A, endo pyrrolizidinone diastereomer [GSK] and several others. Domino reactions therefore constitute an integral part of both creative and functional aspects of drug design and discovery, contributing both enhanced efficiency as well as synthetic versatility to pharmaceutical drug design.

  8. Current status of domino heart transplantation.

    Science.gov (United States)

    Shudo, Yasuhiro; Ma, Michael; Boyd, Jack H; Woo, Yiping Joseph

    2017-03-01

    Domino heart transplant, wherein the explanted heart from the recipient of an en-bloc heart-lung is utilized for a second recipient, represents a unique surgical strategy for patients with end-stage heart failure. With a better understanding of the potential advantages and disadvantages of this procedure, its selective use in the current era can improve and maximize organ allocation in the United States. In this report, we reviewed the current status of domino heart transplantation. © 2017 Wiley Periodicals, Inc.

  9. Domino Oxidative [Pd]-Catalysis: One-Pot Synthesis of Fluorenones Starting from Simple Benzylamines and Iodo Arenes.

    Science.gov (United States)

    Ravi Kumar, Devarapalli; Satyanarayana, Gedu

    2015-12-04

    A domino [Pd]-catalysis for the efficient synthesis of fluorenones is presented. The overall reaction proceeds through the formation of a five membered Pd(II)-cycle via a highly regioselective ortho C(sp(2))-H activation(s) of simple benzylamine that combines with external iodo arenes to give ortho arylated products. Significantly, the reaction further activates the C(sp(3))-H and C(sp(2))-H (intramolecular oxidative Heck coupling) bonds to give tricyclic imine systems. Then the usual water workup affords the fused tricyclic ketones (fluorenones). Remarkably, this one-pot operation enabled the effective construction of two C-C to three C-C bonds.

  10. Domino reactions: More than just a game

    Science.gov (United States)

    Broja, Thomas; Fuchs, Patrick J. W.; Zeitler, Kirsten

    2015-12-01

    Catalytic methods are among the most valuable tools for sustainable synthesis. Domino catalysis enables multiple reactions to be combined so that synthetic efficiency may begin to approach that of nature, but significant challenges remain before this promising approach can fulfil the needs of pharmaceutical and materials chemistry.

  11. Some bijective correspondence involving domino tableaux

    NARCIS (Netherlands)

    Leeuwen, M.A.A. van

    1997-01-01

    We elaborate on the results in ``Splitting the square of a Schur function into its symmetric and antisymmetric parts '' [Carre Leclerc, J. algebr. combinat. 4, 1995]. We give bijective proof of a number of identities that were established there, in particular between the Yamanouchi domino tableaux,

  12. Recipient aging accelerates acquired transthyretin amyloidosis after domino liver transplantation.

    Science.gov (United States)

    Misumi, Yohei; Narita, Yasuko; Oshima, Toshinori; Ueda, Mitsuharu; Yamashita, Taro; Tasaki, Masayoshi; Obayashi, Konen; Isono, Kaori; Inomata, Yukihiro; Ando, Yukio

    2016-05-01

    Domino liver transplantation (DLT) with liver grafts from patients with hereditary transthyretin (TTR) amyloidosis has been performed throughout the world because of a severe liver graft shortage. Reports of acquired systemic TTR amyloidosis in domino liver recipients have been increasing; however, the precise pathogenesis and clinical course of acquired TTR amyloidosis remains unclear. We analyzed the relationship between the occurrence of acquired amyloidosis and clinical features in 22 consecutive domino liver donors with hereditary TTR amyloidosis (10 males and 12 females; mean age at DLT: 37.2 years; TTR mutations: V30M [n = 19], Y114C [n = 1], L55P [n = 1], and S50I [n = 1]) and 22 liver recipients (16 males and 6 females; mean age at DLT, 46.2 years). The mean times from DLT to amyloid first appearance and transplant recipient symptom onset were 8.2 years and 9.9 years, respectively. Kaplan-Meier analysis and quantification of the amyloid deposition revealed aging of recipients correlated with early de novo amyloid deposition. The sex of donors and recipients and the age, disease duration, and disease severity of donors had no significant effect on the latency of de novo amyloid deposition. In conclusion, our results demonstrate that recipient aging is associated with the early onset de novo amyloidosis. Because acquired amyloidosis will likely increase, careful follow-up for early amyloidosis detection and new treatments, including TTR stabilizers and gene-silencing therapies, are required. Liver Transplantation 22 656-664 2016 AASLD. © 2015 American Association for the Study of Liver Diseases.

  13. III. Biological effects of radiation from external and internal sources

    Energy Technology Data Exchange (ETDEWEB)

    Stone, R.S.

    1948-05-24

    This report focuses on the hemotological effects of total body irradiation from external and internal sources observed in patients treated for arthritis with radioactive phosphorus administered intravenously.

  14. External effects related to biogas and wind power

    DEFF Research Database (Denmark)

    Ibsen, Liselotte Schleisner; Nielsen, Per Sieverts

    1998-01-01

    Energy produced by wind power and biogas is today more expensive than energy produced by fossil fuels. However, by including external costs related to the technologies, the renewable technologies are expected to result in social benefits compared to the conventional power technologies. The paper...... will focus on estimates of externalities related to wind and biogas energy supplies using the ExternE methodology developed in a major study launched by the European Comission. External costs are the costs imporsed on society that are not included in the market price (e.g. effects of air pollution on health...

  15. Low Power, Reduced Dynamic Voltage Swing Domino Logic Circuits

    OpenAIRE

    Salendra.Govindarajulu; Dr.T.Jayachandra Prasad; Rangappa, P

    2010-01-01

    Dynamic domino logic circuits are widely used in modern digital VLSI circuits. These dynamic circuits are often favoured in high performance designs because of the speed advantage offered over static CMOS logic circuits. The main drawbacks of dynamic logic are a lack of design automation, a decreased tolerance to noise and increased power dissipation. In this work, new reduced – swing domino logic techniques which provide significant low power dissipation as compared to traditional domino cir...

  16. Domino tableaux, Schutzenberger involution, and the symmetric group action

    CERN Document Server

    Berenstein, A D; Berenstein, Arkady; Kirillov, Anatol N.

    1997-01-01

    We define an action of the symmetric group on the set of domino tableaux, and prove that the number of domino tableaux of a given weight does not depend on the permutation of components of the last. A bijective proof of the well-known result due to J. Stembridge that the number of self-evacuating tableaux of a given shape is equal to that of domino tableaux of the same shape is given.

  17. Domino: Extracting, Comparing, and Manipulating Subsets across Multiple Tabular Datasets

    Science.gov (United States)

    Gratzl, Samuel; Gehlenborg, Nils; Lex, Alexander; Pfister, Hanspeter; Streit, Marc

    2016-01-01

    Answering questions about complex issues often requires analysts to take into account information contained in multiple interconnected datasets. A common strategy in analyzing and visualizing large and heterogeneous data is dividing it into meaningful subsets. Interesting subsets can then be selected and the associated data and the relationships between the subsets visualized. However, neither the extraction and manipulation nor the comparison of subsets is well supported by state-of-the-art techniques. In this paper we present Domino, a novel multiform visualization technique for effectively representing subsets and the relationships between them. By providing comprehensive tools to arrange, combine, and extract subsets, Domino allows users to create both common visualization techniques and advanced visualizations tailored to specific use cases. In addition to the novel technique, we present an implementation that enables analysts to manage the wide range of options that our approach offers. Innovative interactive features such as placeholders and live previews support rapid creation of complex analysis setups. We introduce the technique and the implementation using a simple example and demonstrate scalability and effectiveness in a use case from the field of cancer genomics. PMID:26356916

  18. Application of Lotus Domino / Notes in OA System%Lotus Domino/Notes在OA系统中的应用

    Institute of Scientific and Technical Information of China (English)

    李国强; 王芳

    2012-01-01

    Lotus Domino/Notes是实现和运行办公自动化的最有效的平台之一.本文介绍了Lotus Domino/Notes在办公自动化方面的优势,提出了OA系统的设计思路,并对系统应用Lotus Domino/Notes的部分关键技术进行了讨论.

  19. Experimental study of debris flow caused by domino failures of landslide dams

    Institute of Scientific and Technical Information of China (English)

    Hua-Yong CHEN; Peng CUI; Gordon G.D.ZHOU; Xing-Hua ZHU; Jin-Bo TANG

    2014-01-01

    The formation of landslide dams is often induced by earthquakes in mountainous areas. The failure of a landslide dam typically results in catastrophic flash floods or debris flows downstream. Significant attention has been given to the processes and mechanisms involved in the failure of individual landslide dams. However, the processes leading to domino failures of multiple landslide dams remain unclear. In this study, experimental tests were carried out to investigate the domino failure of landslide dams and the consequent enlargement of downstream debris flows. Different blockage conditions were considered, including complete blockage, partial blockage and erodible bed (no blockage). The mean velocity of the flow front was estimated by videos. Total stress transducers (TSTs) and Laser range finders (LRFs) were employed to measure the total stress and the depth of the flow front, respectively. Under a complete blockage pattern, a portion of the debris flow was trapped in front of each retained landslide dam before the latter collapsed completely. This was accompanied by a dramatic decrease in the mean velocity of the flow front. Conversely, under both partial blockage and erodible bed conditions, the mean velocity of the flow front increased gradually downward along the sloping channel. Domino failures of the landslide dams were triggered when a series of dams (complete blockage and partial blockage) were distributed along the flume. However, not all of these domino failures led to enlarged debris flows. The modes of dam failures have significant impacts on the enlargement of debris flows. Therefore, further research is necessary to understand the mechanisms of domino failures of landslide dams and their effects on the enlargement of debris flows.

  20. Experimental demonstration of illusion optics with ``external cloaking'' effects

    Science.gov (United States)

    Li, Chao; Liu, Xiao; Liu, Guochang; Li, Fang; Fang, Guangyou

    2011-08-01

    A metamaterial "illusion optics" with "complementary medium" and "restoring medium" is designed by using inductor-capacitor (L-C) network medium. The unprecedented effects of "external cloaking" and "transforming one object to appear as another" are demonstrated experimentally. We also demonstrate that the non-resonant nature of the L-C network decreases the sensitivity of the "external cloaking" effect to the variation of the frequency and results in an acceptable bandwidth of the whole device.

  1. 基于Liferay门户与Lotus Domino OA单点登录系统的实现%Implementation of Single Sign-On system Based on Liferay Portal and Lotus Domino OA

    Institute of Scientific and Technical Information of China (English)

    郭成宝

    2014-01-01

    Achieving the SSO(Single Sign-On) between Liferay Portal and Lotus Domino OA, with the advantages of Liferay platform and Domino platform, then we can have better collaboration. Liferay Portal is the effective platform that is running for ofifce automation. This paper introduces the implementation of SSO and the key technologies were discussed.%本文介绍了Liferay门户与lotus Domino OA服务器的单点登录的实现,系统介绍Liferay门户应用优势和Lotus Domino平台在企业协作方面的优势,描述了单点登录认证方式的实现原理,并对其关键技术进行了讨论。

  2. The effect of childhood malnutrition on externalizing behavior.

    Science.gov (United States)

    Liu, Jianghong; Raine, Adrian

    2006-10-01

    Childhood externalizing behavior (aggression, hyperactivity, and conduct disorder) has been increasingly viewed as a public health problem because of its etiology and outcome. The association between malnutrition and externalizing behavior has begun to receive attention. This review summarizes recent empirical findings on malnutrition as a risk factor for the development of externalizing behavior, with an emphasis on micronutrient deficiency, and explores brain dysfunction as a possible mechanism. Externalizing behavior is associated with both macromalnutrition (e.g. protein) and micromalnutrition (e.g. iron and zinc). Both prenatal and postnatal malnutrition is implicated. The long-term effects of malnutrition on behavior could be reversible. The effects of docosahexaenoic acid/omega-3 long-chain essential fatty acid on externalizing behavior are more mixed. From animal and human findings, it is hypothesized that malnutrition impairs neurocognitive functioning by reducing neurons, alternating neurotransmitter functioning, and increasing neurotoxicity, and that such neurocognitive impairments predispose to externalizing behavior. Different lines of evidence support the view that poor nutrition contributes to the development of child behavior problems. More randomized, controlled trials that manipulate nutritional intake and evaluate behavior in children are needed to evaluate the etiological role of nutrition in externalizing behavior in order to inform intervention and prevention efforts.

  3. Wave-spectrum of domino-system

    Science.gov (United States)

    Guzev, Mikhail; Tarasov, Boris

    2016-04-01

    In [1, 2] we proposed a mathematical model of recently identified shear rupture mechanism. This model gives the simplest description of the fan-mechanism and demonstrates that the fan-head represents a self-unbalancing the domino-structure. The domino-structure plays an essential role in determination of rock instability at failure and causes spontaneous rupture development. In the framework of the proposed model it is possible to understand how shear rupture mechanism can provide propagation of faults through the highly confined intact rock mass at shear stress levels significantly less than frictional strength of pre-existing faults. Mathematical model of the domino-structure is described by the system of coupled inverted pendulums. The case of small linear oscillations in a vicinity of the stable equilibrium position is studied and described in the literature [3]. In particular, the wave spectrum is calculated exactly. In our work we considered the mathematical 1D model of the weak coupling inverted pendulums. The corresponding equations for a finite number of pendulums are obtained. We calculated the wave spectrum for the case of linear interaction between pendulums. It was found that there is the critical value of a parameter separating different modes of the wave behavior. This parameter is linked with the dimensionless interaction parameter. If the value of the parameter is less than the critical one we have oscillatory process. In other case the wave spectrum contains exponentially growing contributions and the domino-system is unstable. The asymptotic formula for the critical value with respect to N is proposed in the work. It is shown that the critical value decreases monotonically with respect to N. This investigation was supported by the Russian Scientific Foundation (grant no. 14-11-00079). References [1] Tarasov, B.G., Guzev, M.A., 2013. New insight into the nature of size dependence and the lower limit of rock strength. Proceedings 8th International

  4. Tiling a Pyramidal Polycube with Dominoes

    Directory of Open Access Journals (Sweden)

    Olivier Bodini

    2007-05-01

    Full Text Available The notion of pyramidal polycubes, namely the piling-up of bricks of a non-increasing size, generalizes in ℝ n the concept of trapezoidal polyominoes. In the present paper, we prove that n-dimensional dominoes can tile a pyramidal polycube if and only if the latter is balanced, that is, if the number of white cubes is equal to the number of black ones for a chessboard-like coloration, generalizing the result of [BC92] when n=2

  5. Individual neurophysiological profile in external effects investigation

    Science.gov (United States)

    Schastlivtseva, Daria; Tatiana Kotrovskaya, D..

    Cortex biopotentials are the significant elements in human psychophysiological individuality. Considered that cortical biopotentials are diverse and individually stable, therefore there is the existence of certain dependence between the basic properties of higher nervous activity and cerebral bioelectric activity. The main purpose of the study was to reveal the individual neurophysiological profile and CNS initial functional state manifestation in human electroencephalogram (EEG) under effect of inert gases (argon, xenon, helium), hypoxia, pressure changes (0.02 and 0.2 MPa). We obtained 5-minute eyes closed background EEG on 19 scalp positions using Ag/AgCl electrodes mounted in an electrode cap. All EEG signals were re-referenced to average earlobes; Fast Furies Transformation analysis was used to calculate the relative power spectrum of delta-, theta-, alpha- and beta frequency band in artifact-free EEG. The study involved 26 healthy men who provided written informed consent, aged 20 to 35 years. Data obtained depend as individual EEG type and initial central nervous functional state as intensity, duration and mix of factors. Pronounced alpha rhythm in the raw EEG correlated with their adaptive capacity under studied factor exposure. Representation change and zonal distribution perversion of EEG alpha rhythm were accompanied by emotional instability, increased anxiety and difficulty adapting subjects. High power factor or combination factor with psychological and emotional or physical exertion minimizes individual EEG pattern.

  6. Off-Line Testing for Bridge Faults in CMOS Domino Logic Circuits

    Science.gov (United States)

    Bennett, K.; Lala, P. K.; Busaba, F.

    1997-01-01

    Bridge faults, especially in CMOS circuits, have unique characteristics which make them difficult to detect during testing. This paper presents a technique for detecting bridge faults which have an effect on the output of CMOS Domino logic circuits. The faults are modeled at the transistor level and this technique is based on analyzing the off-set of the function during off-line testing.

  7. Assessment of environmental external effects in power generation

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, H.; Morthorst, P.E.; Schleisner, L. [Risoe National Lab. (Denmark); Meyer, N.I.; Nielsen, P.S.; Nielsen, V. [The Technical Univ. of Denmark (Denmark)

    1996-12-01

    This report summarises some of the results achieved in a project carried out in Denmark in 1994 concerning externalities. The main objective was to identify, quantify and - if possible - monetize the external effects in the production of energy, especially in relation to renewable technologies. The report compares environmental externalities in the production of energy using renewable and non-renewable energy sources, respectively. The comparison is demonstrated on two specific case studies. The first case is the production of electricity based on wind power plants compared to the production of electricity based on a coal-fired conventional plant. In the second case heat/power generation by means of a combined heat and power plant based on biomass-generated gas is compared to that of a combined heat and power plant fuelled by natural gas. In the report the individual externalities from the different ways of producing energy are identified, the stress caused by the effect is assessed, and finally the monetary value of the damage is estimated. The method is applied to the local as well as the regional and global externalities. (au) 8 tabs., 7 ills., 4 refs.

  8. DESIGN OF TERNARY COUNTER BASED ON ADIABATIC DOMINO CIRCUIT

    Institute of Scientific and Technical Information of China (English)

    Yang Qiankun; Wang Pengjun; Zheng Xuesong

    2013-01-01

    By researching the ternary counter and low power circuit design method,a novel design of low power ternary Domino counter on switch-level is proposed.Firstly,the switch-level structure expression of ternary loop operation circuit with enable pin is derived according to the switch-signal theory,and the one bit ternary counter is obtained combining the ternary adiabatic Domino literal operation circuit and buffer.Then the switch-level structure expression of enable signal circuit is derived,and the four bits ternary counter is obtained by cascade connection.Finally,the circuit is simulated by Spice tool and the output waveforms transform in proper order indicating that the logic function is correct.The energy consumption of the four bits ternary adiabatic Domino counter is 63% less than the conventional Domino counterpart.

  9. Effect of externally generated turbulence on wave boundary layer

    DEFF Research Database (Denmark)

    Fredsøe, Jørgen; Sumer, B. Mutlu; Kozakiewicz, A.

    2003-01-01

    This experimental study deals with the effect of externally generated turbulence on the oscillatory boundary layer to simulate the turbulence in the wave boundary layer under broken waves in the swash zone. The subject has been investigated experimentally in a U-shaped, oscillating water tunnel...... with a smooth bottom. Turbulence was generated ´externally´ as the flow in the oscillator was passed through a series of grids, that extended from the cover of the water tunnel to about mid-depth. Two different types of grid porosities were used. Direct measurements of the bed shear stress and velocity...... results. The mean and turbulence quantities in the outer flow region are increased substantially with the introduction of the grids. It is shown that the externally generated turbulence is able to penetrate the bed boundary layer, resulting in an increase in the bed shear stress, and therefore...

  10. Numerical analysis of rainfall effects in external overburden dump

    Institute of Scientific and Technical Information of China (English)

    Radhakanta Koner⇑; Debashish Chakravarty

    2016-01-01

    The effect of slope angle for external overburden dump in response to average and heavy rainfall has been analyzed using a two dimensional finite difference method of transient water flow through unsaturated–saturated soil. The external dump stability is evaluated for five geomaterial types on the basis of globally accepted safety factor analysis technique, based on shear strength reduction approach using finite differ-ence method. The results obtained from the finite difference method of analysis indicate that the external dump with more than 30? slope angle is greatly influenced by the rainfall under the studied conditions for geomaterial 3, 4 and 5, whereas dumps with geomaterial 1 and 2 remain safe. The analysis shows that major slope failure is out of preview for the studied rainfall conditions.

  11. Effects of interaural level differences on the externalization of sound

    DEFF Research Database (Denmark)

    Catic, Jasmina; Santurette, Sébastien; Dau, Torsten

    2012-01-01

    Distant sound sources in our environment are perceived as externalized and are thus properly localized in both direction and distance. This is due to the acoustic filtering by the head, torso, and external ears, which provides frequency-dependent shaping of binaural cues such as interaural level...... differences (ILDs) and interaural time differences (ITDs). In rooms, the sound reaching the two ears is further modified by reverberant energy, which leads to increased fluctuations in short-term ILDs and ITDs. In the present study, the effect of ILD fluctuations on the externalization of sound...... was investigated. A psychoacoustic experiment was performed in a standard IEC 268-13 listening room by normal-hearing listeners. Individual binaural room impulse responses were used to simulate a distant speech source delivered via headphones. The speech signal was then processed such that the naturally occurring...

  12. Reconstruction of the Outflow Tract in Cross-Auxiliary Double-Domino Donor Liver Transplantation.

    Science.gov (United States)

    Qu, W; Zhu, Z-J; Wei, L; Sun, L-Y; Liu, Y; Zeng, Z-G

    2016-10-01

    Auxiliary liver transplantation is accepted as an effective manner to expand the liver donor pool. A difficult surgical technical challenge of the procedure is hepatic vein reconstruction of the graft. To resolve this problem, complex techniques are used to perform an innovative outflow tract reconstruction in the world's first cross-auxiliary double-domino donor liver transplantation with two whole liver grafts. The inferior vena cava-sparing hepatectomy technique was applied at harvest in the two domino liver donors. For each donor, the three major hepatic veins (right, middle, and left) were joined together to create one single orifice, but there was no sufficient tissue to perform a direct anastomosis. The hepatic vein was reconstructed with the use of a longitudinally opened iliac vein graft from a cadaveric donor to prolong the outflow tract for the piggyback suturing. This new technique might provide an innovative surgical approach for reconstructing the complex outflow tract of domino transplantation. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Domino Flaps for Repairing of Secondary Bilateral Cleft Lip With Severe Columella Deformity.

    Science.gov (United States)

    Wei, Jiao; Chiang, Cheng-An; Zhou, Da; Li, Qingfeng; Liu, Kai

    2017-01-01

    The patients with secondary bilateral cleft lip and nasal deformity always suffer from a serious part of the horizontal and vertical soft tissue deficiencies in the upper lip and nose, especially the columella. Normally, the Abbe flap is used to increase the soft tissue volume of upper lip. However, how to reconstruct the sever columella deficient, how to make full use of the Abbe flap and the remaining soft tissue of the upper lip, are always the problems that need to be solved by plastic surgeons. Twenty-nine patients with secondary bilateral cleft lip and severe columella deficiency were simultaneously reconstructed with several local flaps like dominos that was called "Domino sliding flaps." Six of the patients had their nasal tip and dorsum or collumella augmented and modified with autologous costal cartilage at the same time. The other 23 patients underwent the autologous auricular cartilage augmentation. The patients were followed from 15 months to 50 months. No secondary deformation occurred in any of the patients. 93.1% patients were satisfied with the aesthetics postoperatively, 89.7% patients were satisfied with the incision and donor site scar. Among them, 3 of the patients got hypertrophic scar on the upper lip and were modified 1 year after their first operations. The operational technique of the domino sliding flaps could better play the role of the Abbe flap. It also gave plastic surgeons an effective method to modify the severe deformities of bilateral cleft lip in 1 stage.

  14. A Novel Power Reduction Technique for Dual-Threshold Domino Logic in Sub-65nm Technology

    Directory of Open Access Journals (Sweden)

    Tarun Kr. Gupta

    2013-03-01

    Full Text Available A novel technique for dual- threshold is proposed and examined with inputs and clock signals combinationin 65nm dual- threshold footerless domino circuit for reduced leakage current. In this technique a p-typeand an n-type leakage controlled transistor (LCTsare introduced between the pull-up and pull-downnetwork and the gate of one is controlled by the source of the other. A high-threshold transistor is used inthe input for reducing gate oxide leakage current which becomes dominant in nanometer technology.Simulations based on 65nm BISM4 model for proposeddomino circuits shows that CLIL (clock low andinput low and CHIH (clock high and input high state is ineffective for lowering leakage current. TheCLIH (clock low input high state is only effective to suppress the leakage at low and high temperatures forwide fan-in domino circuits but for AND gate CHIL (clock high input low state is preferred to reducetheleakage current. The proposed circuit technique forAND2, OR2, OR4 and OR8 circuits reduces the activepower consumption by 39.6% to 57.9% and by 32.4% to40.3% at low and high die temperaturesrespectively when compared to the standard dual-threshold voltage domino logic circuits.

  15. A Novel Power Reduction Technique for Dual-Threshold Domino Logic in Sub-65nm Technology

    Directory of Open Access Journals (Sweden)

    Tarun Kr. Gupta

    2013-02-01

    Full Text Available A novel technique for dual- threshold is proposed and examined with inputs and clock signals combinationin 65nm dual- threshold footerless domino circuit for reduced leakage current. In this technique a p-typeand an n-type leakage controlled transistor (LCTsare introduced between the pull-up and pull-downnetwork and the gate of one is controlled by the source of the other. A high-threshold transistor is used inthe input for reducing gate oxide leakage current which becomes dominant in nanometer technology.Simulations based on 65nm BISM4 model for proposeddomino circuits shows that CLIL (clock low andinput low and CHIH (clock high and input high state is ineffective for lowering leakage current. TheCLIH (clock low input high state is only effective to suppress the leakage at low and high temperatures forwide fan-in domino circuits but for AND gate CHIL (clock high input low state is preferred to reducetheleakage current. The proposed circuit technique forAND2, OR2, OR4 and OR8 circuits reduces the activepower consumption by 39.6% to 57.9% and by 32.4% to40.3% at low and high die temperaturesrespectively when compared to the standard dual-threshold voltage domino logic circuits.

  16. Effect of External Vibration on PZT Impedance Signature.

    Science.gov (United States)

    Yang, Yaowen; Miao, Aiwei

    2008-11-01

    Piezoelectric ceramic Lead Zirconate Titanate (PZT) transducers, working on the principle of electromechanical impedance (EMI), are increasingly applied for structural health monitoring (SHM) in aerospace, civil and mechanical engineering. The PZT transducers are usually surface bonded to or embedded in a structure and subjected to actuation so as to interrogate the structure at the desired frequency range. The interrogation results in the electromechanical admittance (inverse of EMI) signatures which can be used to estimate the structural health or integrity according to the changes of the signatures. In the existing EMI method, the monitored structure is only excited by the PZT transducers for the interrogating of EMI signature, while the vibration of the structure caused by the external excitations other than the PZT actuation is not considered. However, many structures work under vibrations in practice. To monitor such structures, issues related to the effects of vibration on the EMI signature need to be addressed because these effects may lead to misinterpretation of the structural health. This paper develops an EMI model for beam structures, which takes into account the effect of beam vibration caused by the external excitations. An experimental study is carried out to verify the theoretical model. A lab size specimen with different external excitations is tested and the effect of vibration on EMI signature is discussed.

  17. Effect of External Vibration on PZT Impedance Signature

    Directory of Open Access Journals (Sweden)

    Yaowen Yang

    2008-11-01

    Full Text Available Piezoelectric ceramic Lead Zirconate Titanate (PZT transducers, working on the principle of electromechanical impedance (EMI, are increasingly applied for structural health monitoring (SHM in aerospace, civil and mechanical engineering. The PZT transducers are usually surface bonded to or embedded in a structure and subjected to actuation so as to interrogate the structure at the desired frequency range. The interrogation results in the electromechanical admittance (inverse of EMI signatures which can be used to estimate the structural health or integrity according to the changes of the signatures. In the existing EMI method, the monitored structure is only excited by the PZT transducers for the interrogating of EMI signature, while the vibration of the structure caused by the external excitations other than the PZT actuation is not considered. However, many structures work under vibrations in practice. To monitor such structures, issues related to the effects of vibration on the EMI signature need to be addressed because these effects may lead to misinterpretation of the structural health. This paper develops an EMI model for beam structures, which takes into account the effect of beam vibration caused by the external excitations. An experimental study is carried out to verify the theoretical model. A lab size specimen with different external excitations is tested and the effect of vibration on EMI signature is discussed.

  18. Effects of external stress on defect complexes in semiconductors

    Energy Technology Data Exchange (ETDEWEB)

    Tessema, Genene [Department of Physics, Addis Ababa University, PO Box 1176, Addis Ababa (Ethiopia); Helmholtz-Institut fuer Strahlen und Kernphysik, Nussalle 14-16, 53115 Bonn (Germany)

    2007-07-04

    Crystal field gradients that exist at lattice sites in solids depend on the symmetry of charge distribution around atomic sites. The charge symmetry could be broken either by the presence of impurity complexes in the host matrix or by external stress on the samples, which leads to an observable magnitude of electric field gradients (EFGs). The perturbed {gamma}-{gamma} angular correlation (PAC) method is employed here to investigate the effect of uniaxial stress on {sup 111}Cd sites in crystalline doped semiconductors.

  19. Beam-beam effects under the influence of external noise

    CERN Document Server

    Ohmi, K.

    2014-01-01

    Fast external noise, which gives fluctuation into the beam orbit, is discussed in connection with beam-beam effects. Phase noise from crab cavities and detection devices (position monitor) and kicker noise from the bunch by bunch feedback system are the sources. Beam-beam collisions with fast orbit fluctuations with turn by turn or multi-turn correlations, cause emittance growth and luminosity degradation. We discuss the tolerance of the noise amplitude for LHC and HL-LHC.

  20. Representations of knowledge about dominoes in demented and normal elderly players.

    Science.gov (United States)

    Beatty, W W; English, S; Dean, K; Rogers, C L; Olson, K A

    1999-04-01

    1. Dementia patients who retain musical and game-playing skills exhibit impaired performance on explicit memory tests of knowledge about their retained skill. 2. Dementia patients who retain skill at playing dominoes can answer complex questions about the play of the game almost as well as normal elderly domino players when the questions are presented with real dominoes. 3. The aim of this study was to determine if skilled dementia patients could answer questions about domino play when the stimuli were two-dimensional drawings of dominoes. 4. Seventeen dementia patients and eight normal elderly domino players were tested on two forms of the Domino Quiz: first with real dominoes, then with two-dimensional drawings; other neuropsychological tests were given at the same time. 5. Fourteen of the 17 patients and all of the controls showed no decline in answering questions about domino play when two-dimensional drawings were used. These patients showed retained symbolic processing of information about dominoes despite declines in overall mental status, generation of words from specific semantic categories, and recognition memory for domino terminology. 6. Because the 14 patients with retained domino skill performed as accurately as controls on both administrations of a letter cancellation task, the ability to process familiar symbols may be important to their game-playing skill.

  1. A Distributed AI Aided 3D Domino Game

    CERN Document Server

    Amrahov, Şahin Emrah

    2010-01-01

    In the article a turn-based game played on four computers connected via network is investigated. There are three computers with natural intelligence and one with artificial intelligence. Game table is seen by each player's own view point in all players' monitors. Domino pieces are three dimensional. For distributed systems TCP/IP protocol is used. In order to get 3D image, Microsoft XNA technology is applied. Domino 101 game is nondeterministic game that is result of the game depends on the initial random distribution of the pieces. Number of the distributions is equal to the multiplication of following combinations: . Moreover, in this game that is played by four people, players are divided into 2 pairs. Accordingly, we cannot predict how the player uses the dominoes that is according to the dominoes of his/her partner or according to his/her own dominoes. The fact that the natural intelligence can be a player in any level affects the outcome. These reasons make it difficult to develop an AI. In the article ...

  2. [Development of domino reactions based on skeletal rearrangement].

    Science.gov (United States)

    Sugimoto, Kenji

    2011-01-01

    Domino reactions, which enable formations of several chemical bonds and multi-step transformation in one-pot process, have received much attention as an efficient synthetic methodology to preserve chemists from time-consuming purification protocols and protection-deprotection procedures. Furthermore, the domino processes containing skeletal rearrangement have been utilized for constructions of complex molecules because of their potential that they could afford entirely different valuable structures from readily available simple substrates. We recently developed novel domino reactions including ring enlargement process, which could afford biologically important cyclopentanones and nitrogen heterocycles. In this review, we will describe 1) a novel type of palladium-catalyzed domino insertion-ring expansion reaction of dienylcyclobutanols, which could enable a stereospecific synthesis of (Z)-2-(3-aryl-1-propenyl)cyclopentanones, 2) ruthenium-catalyzed domino ring expansion-insertion reaction of 1-acetylenylcyclobutanols for a construction of 2-alkylidenecyclopentanones, and 3) DIBALH-mediated reductive ring expansion reaction of oximes and studies on the reaction mechanisms. The rationales for the observed stereoselectivities in each reaction are also discussed.

  3. Cost-Effective Abatement of Multiple Production Externalities

    Science.gov (United States)

    Connor, Jeffery D.; Perry, Gregory M.; Adams, Richard M.

    1995-07-01

    This article explores the issue of multiple externalities through a case study of irrigated agricultural production in eastern Oregon. A mathematical programming model is used to demonstrate the manner in which a policy directed at one externality (soil erosion) may influence the incidence of another externality (groundwater pollution). A key determinant of multiple externality outcomes is interdependence in the processes producing agricultural commodities and externalities. Potential benefits from coordinating a policy to address multiple environmental objectives are discussed.

  4. Ratchet effect on a relativistic particle driven by external forces

    Energy Technology Data Exchange (ETDEWEB)

    Quintero, Niurka R [Departamento de Fisica Aplicada I, Escuela Universitaria Politecnica, Universidad de Sevilla, Calle Virgen de Africa 7, E-41011 Sevilla (Spain); Alvarez-Nodarse, Renato [Departamento de Analisis Matematico, Facultad de Matematicas, Universidad de Sevilla, Apdo 1160, E-41080 Sevilla (Spain); Cuesta, Jose A, E-mail: niurka@us.es, E-mail: ran@us.es, E-mail: cuesta@math.uc3m.es [Grupo Interdisciplinar de Sistemas Complejos (GISC), Departamento de Matematicas, Universidad Carlos III de Madrid, Avenida de la Universidad 30, E-28911 Leganes, Madrid (Spain)

    2011-10-21

    We study the ratchet effect of a damped relativistic particle driven by both asymmetric temporal bi-harmonic and time-periodic piecewise constant forces. This system can be formally solved for any external force, providing the ratchet velocity as a nonlinear functional of the driving force. This allows us to explicitly illustrate the functional Taylor expansion formalism recently proposed for this kind of systems. The Taylor expansion reveals particularly useful to obtain the shape of the current when the force is periodic, piecewise constant. We also illustrate the somewhat counterintuitive effect that introducing damping may induce a ratchet effect. When the force is symmetric under time-reversal and the system is undamped, under symmetry principles no ratchet effect is possible. In this situation increasing damping generates a ratchet current which, upon increasing the damping coefficient eventually reaches a maximum and decreases toward zero. We argue that this effect is not specific of this example and should appear in any ratchet system with tunable damping driven by a time-reversible external force. (paper)

  5. Significance assessment of the external control effects of lecturers

    Directory of Open Access Journals (Sweden)

    Kurbatova Margarita, V.

    2015-06-01

    Full Text Available The state policy regarding higher education has changed in the last decade. These changes were part of the efficiency programs of the public sector. Governments of different countries ruined previously existing system of higher education state regulation and attempted to build the quasi-market structure in the higher education industry. Such transformations served as timely and progressive reforms in the recent studies of the economics of education. Substitution of bureaucratic management mechanisms and modern competition managerial tools are articulated. Economic and institutional and sociological studies on the effects of the introduction of quasi-markets and managerial tools in higher education governance oppose to orthodox market approach. They drew attention to the fact that evaluation methods and improve the effectiveness of organizations and employees that are typical of the private sector often produce results that differ from those in the public sector. To assess the consequences of the introduction of managerial tools of external control activities of university lecturers used a methodology based on the allocation of the individual structural components (effects and building on their basis of a multi-level hierarchical model in the research. Each component of the model (single effect is characterized by a degree of significance (importance and the degree of severity. The results of the systematization and assessment of the significance of the effects of external control activity of lecturers of Russian universities implemented in conditions of quasi-market mechanisms of the higher education system are highlighted in the paper.

  6. A domino model for geomagnetic field reversals

    CERN Document Server

    Mori, N; Ferriz-Mas, A; Wicht, J; Mouri, H; Nakamichi, A; Morikawa, M

    2011-01-01

    We solve the equations of motion of a one-dimensional planar Heisenberg (or Vaks-Larkin) model consisting of a system of interacting macro-spins aligned along a ring. Each spin has unit length and is described by its angle with respect to the rotational axis. The orientation of the spins can vary in time due to random forcing and spin-spin interaction. We statistically describe the behaviour of the sum of all spins for different parameters. The term "domino model" in the title refers to the interaction among the spins. We compare the model results with geomagnetic field reversals and find strikingly similar behaviour. The aggregate of all spins keeps the same direction for a long time and, once in a while, begins flipping to change the orientation by almost 180 degrees (mimicking a geomagnetic reversal) or to move back to the original direction (mimicking an excursion). Most of the time the spins are aligned or anti-aligned and deviate only slightly with respect to the rotational axis (mimicking the secular v...

  7. Iatrogenic amyloid polyneuropathy after domino liver transplantation.

    Science.gov (United States)

    Mnatsakanova, Diana; Živković, Saša A

    2017-01-28

    Liver transplantation has been used in treatment of transthyretin amyloidosis, and some patients undergo domino liver transplantation (DLT) with explanted liver being transplanted to another patient with liver failure as the liver is otherwise usually functionally normal. Until end of 2015, there were 1154 DLT performed worldwide. DLT for transthyretin amyloidosis is associated with the risk of developing de novo systemic amyloidosis and amyloid neuropathy, and the risk may be greater with some non-Val30Met mutations. De novo amyloid neuropathy has been described in up to 23% of transplant recipients. Neuropathy may be preceded by asymptomatic amyloid deposition in various tissues and symptoms of neuropathy started after a median of 7 years following DLT (5.7 ± 3.2 years; range 2 mo to 10 years). Typical initial symptoms include neuropathic pain and sensory loss, while dysautonomia usually starts later. Progression of neuropathy may necessitate liver re-transplantation, and subsequent improvement of neuropathy has been reported in some patients. Explant allograft recipients need close monitoring for signs of systemic amyloidosis, neuropathy and dysautonomia as progressive symptoms may require re-transplantation.

  8. Biological Derived Nanomotors in a ``Domino Fashion''

    Science.gov (United States)

    Maksoed, W. H.

    2015-11-01

    For disproportionation of H2 O2 , we also considers an electrokinetic mechanism they appear.So far, the more efficient micro/nanoscale motors are derived from biological systems [2003]. Besides, a control experimenting using 3 stripped Au/Pt/Au rods with catalyzed the composition of H2 O2 , at a similar rate-Walter F Paxton: ``Catalytic Nanomotors,'' JACS, 2004. We also intended to accomaplishes the HCCI quotes from Marcin Frackowiak, dissertation, 2009, just in several characters seems as twin of IGNITION through IceCube document project held since Oct 11, 2001 ever concludes as ``saw none'' so they can be follows the ITER/IFMIF. Refers to S29286 file in UI retrieved: ``magnetic quantum-dot cellular automata which is nonvolatile & lower power consist of nanomagnets. Since they are magnetically coupled, logic can be performed by switching, on the other hand in a DOMINO fashion..'' [A. Klenm: ``Fabrication of Magnetic Tunnel Junction-based Spintronic Devices..,'' convocation, Aug 11-14, 2010]. Acknowledgments devotes to BB Mandelbrot: ``Fractal Geometry: What is it & What Does it do?''.

  9. Domino Web服务器的设置

    Institute of Scientific and Technical Information of China (English)

    蒋伟民

    2002-01-01

    @@ Lotus Domino服务器具备了作为Internet和Intranet主机服务器的所有要求,如具有标准的In-ternet邮件系统、群体、交互式Web站点等功能.使用Domino在Web方面的强大功能,可以创建交互式的、动态的、安全的Web站点.为了使Web服务器发挥作用,首先必须设置好Domino Web服务器.本文以Domino Server 4.6为例说明DominoWeb服务器的设置.

  10. Constraining the effective action by a method of external sources

    CERN Document Server

    Garbrecht, Bjorn

    2015-01-01

    We propose a novel method of evaluating the effective action, wherein the physical one- and two-point functions are obtained in the limit of non-vanishing external sources. We illustrate the self-consistency of this method by recovering the usual 2PI effective action due to Cornwall, Jackiw and Tomboulis, differing only by the fact that the saddle-point evaluation of the path integral is performed along the extremal quantum, rather than classical, path. As such, this approach is of particular relevance to situations where the dominant quantum and classical paths are non-perturbatively far away from one-another. A pertinent example is the decay of false vacua in radiatively-generated potentials, as may occur for the electroweak vacuum of the Standard Model. In addition, we describe how the external sources may instead be chosen so as to yield the two-particle-point-irreducible (2PPI) effective action of Coppens and Verschelde. Finally, in the spirit of the symmetry-improved effective action of Pilaftsis and Te...

  11. Domino/Notes调用SQL数据库技术方案研究%The Research of Technology in Domino/Notes Transferring SQL Database

    Institute of Scientific and Technical Information of China (English)

    汪本标

    2005-01-01

    以通信公司的大客户系统为例,研究了Lotus Domino/Notes查询调用SQL数据库的方案与实现技术.首先对Lotus Domino/Notes的背景应用进行了总结,然后具体分析了Lotus Domino/Notes调用SQL数据库的方案及其实现技术.

  12. On the MOND External Field Effect in the Solar System

    CERN Document Server

    Iorio, Lorenzo

    2009-01-01

    In the framework of the MOdified Newtonian Dynamics (MOND), the internal dynamics of a gravitating system s embedded in a larger one S is affected by the external background field E of S even if it is constant and uniform, thus implying a violation of the Strong Equivalence Principle: it is the so-called External Field Effect (EFE). In the case of the solar system, E would be A_cen\\approx 10^-10 m s^-2 because of its motion through the Milky Way: it is orders of magnitude smaller than the main Newtonian monopole terms for the planets. We address here the following questions in a purely phenomenological manner: are the Sun's planets affected by an EFE as large as 10^-10 m s^-2? Can it be assumed that its effect is negligible for them because of its relatively small size? Does $\\bds E$ induce vanishing net orbital effects because of its constancy over typical solar system's planetary orbital periods? It turns out that a constant and uniform acceleration, treated perturbatively, does induce non-vanishing long-pe...

  13. Enantioselective Stereodivergent Nucleophile-Dependent Isothiourea-Catalysed Domino Reactions.

    Science.gov (United States)

    Matviitsuk, Anastassia; Taylor, James E; Cordes, David B; Slawin, Alexandra M Z; Smith, Andrew D

    2016-12-05

    α,β-Unsaturated acyl ammoniums generated from the reaction of α,β-unsaturated 2,4,6-trichlorophenol (TCP) esters bearing a pendent enone with an isothiourea organocatalyst are versatile intermediates in a range of enantioselective nucleophile-dependent domino processes to form complex products of diverse topology with excellent stereoselectivity. Use of either 1,3-dicarbonyls, acyl benzothiazoles, or acyl benzimidazoles as nucleophiles allows three distinct, diastereodivergent domino reaction pathways to be accessed to form various fused polycyclic cores containing multiple contiguous stereocentres. © 2016 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

  14. the effect of external knowledge on brand equity

    Directory of Open Access Journals (Sweden)

    sajad khani

    2014-09-01

    Full Text Available Most traditional organizations managers focus on tangible and financial assets such as land, money, labor and ... One of the industries where competition is intense day by day the concept of competitive advantage and value creation in its resolution finds the banking industry. In this regard, the present study sought to examine the impact of intangible assets (external knowledge to improve service quality and brand equity in the banking industry and the Export Development Bank of Iran. This type of survey and the statistical community with both customers and employees. Sampling survey is stratified, the sample size is 384 customers Cochran formula and the size of the staff, according to Morgan, is 86. Well for structural equation modeling analysis of data, ‌ Model (SEM and Confirmatory Factor Analysis (CFA is used. Research findings show that external knowledge is directly significant effect on brand equity. Also, the effect of foreign knowledge through knowledge chain mediator variable exerts a positive impact on the quality of service and if there is a direct impact of foreign knowledge will affect the quality of service. The changing role of mediating variable chain is very strong. Significant impact on brand equity but also the quality of individual customers, suppliers and competitors are not the only dimensions of brand equity through a chain of significant impact on brand equity to the.

  15. The Domino Effect of a New Vision.

    Science.gov (United States)

    Hanson, Linda M.

    1992-01-01

    At Mundelein (Illinois) High School, alternative assessments of student learning (portfolios, debates, learning logs, interviews, mock trials, and research reports) are replacing traditional testing practices. Alternative assessment bumped into everything else, necessitating changes in master scheduling, records management, curriculum, and teacher…

  16. Domino Effect on Electricity and Coal Prices?

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ In the middle of last December, the key purchase contracts for coal used in power generation in 2008 were signed, reflecting a demand for more than 1.085 billion tons. It is important to note that the country's five biggest power producers, China Huaneng Group, China Guodian Corporation, China Power Investment Corporation, China Huadian Corporation and China Datang Corporation, had settled on the prices on their purchase contracts, and they are expected to consume 290 million tons of coal for generating electricity, accounting for half of the major purchase contracts.

  17. The Domino Effect of a New Vision.

    Science.gov (United States)

    Hanson, Linda M.

    1992-01-01

    At Mundelein (Illinois) High School, alternative assessments of student learning (portfolios, debates, learning logs, interviews, mock trials, and research reports) are replacing traditional testing practices. Alternative assessment bumped into everything else, necessitating changes in master scheduling, records management, curriculum, and teacher…

  18. Autism and Externalizing Behaviors: Buffering Effects of Parental Emotion Coaching

    Science.gov (United States)

    Wilson, Beverly J.; Berg, Jessica L.; Zurawski, Megan E.; King, Kathleen A.

    2013-01-01

    The purpose of this study was to examine the relation between parental emotion coaching and externalizing behaviors in children with autism spectrum disorders (ASD). Children with ASD often exhibit externalizing behaviors, particularly emotionally driven externalizing behaviors, at a higher rate than their typically developing peers. An…

  19. Autism and Externalizing Behaviors: Buffering Effects of Parental Emotion Coaching

    Science.gov (United States)

    Wilson, Beverly J.; Berg, Jessica L.; Zurawski, Megan E.; King, Kathleen A.

    2013-01-01

    The purpose of this study was to examine the relation between parental emotion coaching and externalizing behaviors in children with autism spectrum disorders (ASD). Children with ASD often exhibit externalizing behaviors, particularly emotionally driven externalizing behaviors, at a higher rate than their typically developing peers. An…

  20. The destabilizing effect of external damping: Singular utter boundary for the Pfluger column with vanishing external dissipation

    CERN Document Server

    Tommasini, Mirko; Misseroni, Diego; Bigoni, Davide

    2016-01-01

    Elastic structures loaded by nonconservative positional forces are prone to instabilities induced by dissipation: it is well-known in fact that internal viscous damping destabilizes the marginally stable Ziegler's pendulum and Pfluger column (of which the Beck's column is a special case), two structures loaded by a tangential follower force. The result is the so-called 'destabilization paradox', where the critical force for flutter instability decreases by an order of magnitude when the coefficient of internal damping becomes infinitesimally small. Until now external damping, such as that related to air drag, is believed to provide only a stabilizing effect, as one would intuitively expect. Contrary to this belief, it will be shown that the effect of external damping is qualitatively the same as the effect of internal damping, yielding a pronounced destabilization paradox. Previous results relative to destabilization by external damping of the Ziegler's and Pfluger's elastic structures are corrected in a defi...

  1. HOW DO FIRMS SOURCE EXTERNAL KNOWLEDGE FOR INNOVATION? ANALYSING EFFECTS OF DIFFERENT KNOWLEDGE SOURCING METHODS

    OpenAIRE

    KI H. KANG; JINA KANG

    2009-01-01

    In the era of "open innovation", external knowledge is a very important source for technology innovation. In this paper, we investigate the relationship between external knowledge and performance of technology innovation. The effect of external knowledge on the performance of technology innovation can vary with different external knowledge sourcing methods. We identify three ways of external knowledge sourcing: information transfer from informal network, R&D collaboration and technology acqui...

  2. Radiotherapy of bile duct carcinoma; Effectiveness of external irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Shiina, Takeki; Itami, Jun; Uno, Takashi; Kato, Hajime; Tani, Masanao; Kawai, Saburou (National Medical Center of Hospital, Tokyo (Japan))

    1992-10-01

    Twenty-six patients with cholangiocarcinoma and nineteen patients with carcinoma of the gallbladder treated with external radiotherapy were analyzed. Of the twenty-six patients, eighteen had cancer of the hepatic hilus (Klatskin), four intrahepatic and the remaining four extrahepatic cholangiocarcinoma. All but two of the patients had advanced disease. Thirty-three patients received primary irradiation for unresectable tumors, ten patients adjuvant irradiation after non-curative gross tumor resection, and two patients preoperative radiotherapy. Patients with cholangiocarcinoma who underwent radiotherapy with relatively small radiation field tolerated the treatment well, but there was no significant difference in survival according to field size or radiation doses (TDF). On the other hand, patients with carcinoma of gallbladder were treated with larger field size and lower dose. In the patients without gross tumor resection, those receiving radiation doses[>=]90 TDF had significantly longer survival than <90 TDF (p<0.05). Regarding to the field size, patients irradiated by smaller field size ([<=]100 cm[sup 2]) had longer survival (p=0.07). The patients with gross tumor resection had significantly longer survival than that without resection in both cholangiocarcinoma and carcinoma of gallbladder. Postmortem examination revealed tumor recurrence even in the patients with gross tumor resection, but widespread distant metastases were present simultaneously. Cholangitis and liver abscess were special and lethal conditions related to these carcinomas, and intensive therapy must be developed for these conditions. External radiotherapy may be effective in the treatment of bile duct carcinoma in terms of palliation and survival. (author).

  3. Arctic circles, domino tilings and square Young tableaux

    CERN Document Server

    Romik, Dan

    2009-01-01

    The arctic circle theorem of Jockusch, Propp, and Shor asserts that uniformly random domino tilings of an Aztec diamond of high order are frozen with asymptotically high probability outside the "arctic circle" inscribed within the diamond. A similar arctic circle phenomenon has been observed in the limiting behavior of random square Young tableaux. In this paper, we show that random domino tilings of the Aztec diamond are asymptotically related to random square Young tableaux in a more refined sense that looks also at the behavior inside the arctic circle. This is done by giving a new derivation of the limiting shape of the height function of a random domino tiling of the Aztec diamond that uses the large-deviation techniques developed for the square Young tableaux problem in a previous paper by Pittel and the author. The solution of the variational problem that arises for domino tilings is almost identical to the solution for the case of square Young tableaux by Pittel and the author. The analytic techniques...

  4. 'Domino' systems biology and the 'A' of ATP

    NARCIS (Netherlands)

    Verma, M.; Zakhartsev, M.; Reuss, M.; Westerhoff, H.V.

    2013-01-01

    We develop a strategic 'domino' approach that starts with one key feature of cell function and the main process providing for it, and then adds additional processes and components only as necessary to explain provoked experimental observations. The approach is here applied to the energy metabolism o

  5. Domino congres brengt waterpartijen bij elkaar rond informatiemanagement

    NARCIS (Netherlands)

    Peters, R.; Os, N. van; Spaling, G.; Willems, R.F.W.M.

    2015-01-01

    Op 20, 21 en 22 mei vond in Zwijndrecht het Dominocongres plaats. Domino adresseert de uitdaging van een “common operational picture” bij een groot overstromingsincident en de rol van informatiemanagement. Het IFV en de regio Zuid-Holland Zuid traden op als gastheer van een aantal geschakelde evenem

  6. 'Domino' systems biology and the 'A' of ATP

    NARCIS (Netherlands)

    Verma, M.; Zakhartsev, M.; Reuss, M.; Westerhoff, H.V.

    2013-01-01

    We develop a strategic 'domino' approach that starts with one key feature of cell function and the main process providing for it, and then adds additional processes and components only as necessary to explain provoked experimental observations. The approach is here applied to the energy metabolism o

  7. Radical addition-initiated domino reactions of conjugated oxime ethers.

    Science.gov (United States)

    Ueda, Masafumi

    2014-01-01

    The application of conjugated oxime ethers to the synthesis of complex chemical scaffolds using domino radical reactions has been described in detail. The triethylborane-mediated hydroxysulfenylation reaction allows for the regioselective construction of a carbon-sulfur bond and a carbon-oxygen bond in a single operation for the formation of β-hydroxy sulfides. This reaction proceeds via a radical pathway involving regioselective thiyl addition and the subsequent trapping of the resulting α-imino radical with O₂, where the imino group enhances the stability of the intermediate radical. Hydroxyalkylation reactions that occur via a carbon radical addition reaction followed by the hydroxylation of the resulting N-borylenamine with O₂ have also been developed. We investigated sequential radical addition aldol-type reactions in detail to explore the novel domino reactions that occur via the generation of N-borylenamine. The radical reaction of a conjugated oxime ether with triethylborane in the presence of an aldehyde affords γ-butyrolactone via sequential processes including ethyl radical addition, the generation of N-borylenamine, an aldol-type reaction with an aldehyde, and a lactonization reaction. A novel domino reaction has also been developed involving the [3,3]-sigmatropic rearrangement of N-boryl-N-phenoxyenamine. The triethylborane-mediated domino reactions of O-phenyl-conjugated oxime ethers afforded the corresponding benzofuro[2,3-b]pyrrol-2-ones via a radical addition/[3,3]-sigmatropic rearrangement/cyclization/lactamization cascade.

  8. 'Domino' systems biology and the 'A' of ATP

    NARCIS (Netherlands)

    Verma, M.; Zakhartsev, M.; Reuss, M.; Westerhoff, H.V.

    2013-01-01

    We develop a strategic 'domino' approach that starts with one key feature of cell function and the main process providing for it, and then adds additional processes and components only as necessary to explain provoked experimental observations. The approach is here applied to the energy metabolism

  9. Late biological effects from internal and external exposure

    Energy Technology Data Exchange (ETDEWEB)

    Adams, W.H.

    1985-01-01

    Information on late biological effects of radiation was obtained from the long-term medical followup of a small population of Marshallese accidentally exposed to radioactive fallout from a thermonuclear test in 1954. Endocrine data are compatible with a sequence of nonstochastic radiation effects. The ingestion of radioisotopes of iodine produced clinical thyroid hypofunction in children, biochemical evidence of thyroid dysfunction in some adults, thyroid adenomatous module formation, and, as a possible indirect effect of thyroid damage, at least two cases of pituitary adenoma. In contrast, the only evidence of a stochastic effect has been a real increase in thyroid cancers among the more highly exposed people of Rongelap, none of whom have evidence of residual disease. While three nonthyroidal cancers which are known to be inducible in humans by external irradiation have been documented in the exposed population, three similar cancers have occurred in an unexposed comparison population of Marshallese. Nonstochastic effects of radiation exposure may be common but subtle. In the Marshallese experience the morbidity of delayed nonstochastic effects far exceeds that of the stochastic. 20 refs., 5 figs., 1 tab.

  10. Externality in the nonobese: effects of environmental responsiveness on weight.

    Science.gov (United States)

    Rodin, J; Slochower, J

    1976-03-01

    The study considered whether external responsiveness in normal weight people would predict changes in eating behavior and weight following major alteration of environmetnal food cues. Normal weight children were tested for externality on measures of eating, slide recall, and extremity of affective responsiveness during the first week of a summer camp, and were weighed biweekly thereafter. There was a significant correlation between externality and weight change, indicating that the more externally responsive the children were, the more weight they gained. The implications of this finding for theories about the development of obesity were considered.

  11. Leading multiple teams: average and relative external leadership influences on team empowerment and effectiveness.

    Science.gov (United States)

    Luciano, Margaret M; Mathieu, John E; Ruddy, Thomas M

    2014-03-01

    External leaders continue to be an important source of influence even when teams are empowered, but it is not always clear how they do so. Extending research on structurally empowered teams, we recognize that teams' external leaders are often responsible for multiple teams. We adopt a multilevel approach to model external leader influences at both the team level and the external leader level of analysis. In doing so, we distinguish the influence of general external leader behaviors (i.e., average external leadership) from those that are directed differently toward the teams that they lead (i.e., relative external leadership). Analysis of data collected from 451 individuals, in 101 teams, reporting to 25 external leaders, revealed that both relative and average external leadership related positively to team empowerment. In turn, team empowerment related positively to team performance and member job satisfaction. However, while the indirect effects were all positive, we found that relative external leadership was not directly related to team performance, and average external leadership evidenced a significant negative direct influence. Additionally, relative external leadership exhibited a significant direct positive influence on member job satisfaction as anticipated, whereas average external leadership did not. These findings attest to the value in distinguishing external leaders' behaviors that are exhibited consistently versus differentially across empowered teams. Implications and future directions for the study and management of external leaders overseeing multiple teams are discussed.

  12. The effects of external conditions in turbulent boundary layers

    Science.gov (United States)

    Brzek, Brian G.

    The effects of multiple external conditions on turbulent boundary layers were studied in detail. These external conditions include: surface roughness, upstream turbulence intensity, and pressure gradient. Furthermore, the combined effects of these conditions show the complicated nature of many realistic flow conditions. It was found that the effects of surface roughness are difficult to generalize, given the importance of so many parameters. These parameters include: roughness geometry, roughness regime, roughness height to boundary layer thickness, (k/delta), roughness parameter, ( k+), Reynolds number, and roughness function (Delta B+). A further complication, is the difficulty in computing the wall shear stress, tauw/rho. For the sand grain type roughness, the mean velocity and Reynolds stresses were studied in inner and outer variables, as well as, boundary layer parameters, anisotropy tensor, production term, and viscous stress and form drag contributions. To explore the effects of roughness and Reynolds number dependence in the boundary layer, a new experiment was carefully designed to properly capture the x-dependence of the single-point statistics. It was found that roughness destroys the viscous layer near the wall, thus, reducing the contribution of the viscous stress in the wall region. As a result, the contribution in the skin friction due to form drag increases, while the viscous stress decreases. This yields Reynolds number invariance in the skin friction, near-wall roughness parameters, and inner velocity profiles as k + increases into the fully rough regime. However, in the transitionally rough regime, (i.e., 5 component shows the largest influence of roughness, where the high peak near the wall was decreased and became nearly flat for the fully rough regime profiles. In addition, the Reynolds stresses in outer variables show self-similarity for fixed experimental conditions. However, as the roughness parameter, k +, increases, all Reynolds stress

  13. Domino Accumulation Analysis and Design of Thermal Radiation Accident Based on GIS%基于GIS热辐射事故多米诺叠加分析与设计

    Institute of Scientific and Technical Information of China (English)

    李俊华; 赵跃华; 刘俊; 周宁

    2012-01-01

    The definition of domino effect is introduced and the specific processes of thermal radiation incident domino effect quantitative evaluation are given. Based on the inducing conditions and modes of domino effect, the thermal radiation incident domino stack algorithm analysis is studied. Software for analyzing thermal radiation accumulation in domino accidents and its corresponding design steps has been designed by geographic information system. It has been employed to calculate the probability accumulation in some complex domino accidents. According to the probability of the happening about the domino effect, the results can be more vividly dynamic forecasting the accident further development trend that is instructionally meaningful for rescue to make decisions and for safety management and rescue plan making.%引入多米诺效应的定义,给出热辐射事故多米诺效应定量评价的具体流程.在触发多米诺效应发生条件和发生模式的基础上,重点研究了热辐射事故多米诺叠加算法分析.利用地理信息系统设计了多米诺事故热辐射叠加分析软件以及相应的设计步骤,解决较为复杂的重大事故多米诺效应概率叠加计算问题.根据多米诺效应的发生概率,研究结果可以更加形象地动态预测事故进一步发展的趋势,为救援指挥提供决策,对相关园区的安全管理和救援决策具有指导意义.

  14. Effect of external stents on prevention of intimal hyperplasia in a canine vein graft model

    Institute of Scientific and Technical Information of China (English)

    ZOU Rong-jiang; ZOU Liang-jian; HUANG Sheng-dong; WANG Yin; HAN Lin; JI Guang-yu; XU Zhi-yun

    2007-01-01

    Background External stents have been used to reduce intimal hyperplasia of vein grafts.The aim of the present study was to define the size of an external stent appropriate for a particular graft by comparing vein grafts with different sizes of external stents.Methods A series of paired trials was performed to compare femoral vein grafts with different sizes of external stents,where 30 modeled canines were equally divided into three groups:6-mm external stent vs non-stent control,4-mm vs 6-mm external stent,and 4-mm vs 8-mm external stent.At day 3 after operation,color Doppler flow imaging(CDFI)was done to observe blood flow in the lumen.Four weeks later,CDFI was re-checked and the veins were harvested,stained and measured.Results All grafts were patent without formation of thrombosis.External stents significantly reduced intimal thickness of the vein grafts with a 6-mm external stent compared with the vein grafts without external stents(P<0.05).The vein grafts with the 4-mm external stent had similar intimal, medial and adventitial thicknesses compared with those with the 6-mm external stent and the 8-mm external stent.Conclusions External stents can reduce intimal hyperplasia of vein grafts.Stents of different diameters exert the similar effect on prevention of intimal hyperplasia.

  15. EXTERNAL DEBTS SUSTAINABILITY, IMF POLICIES EFFECT AND TURKEY SAMPLE

    Directory of Open Access Journals (Sweden)

    Faik A EL K

    2008-10-01

    Full Text Available It is generally recognized that developing countries need substantial amounts of net transfer of resources at early stages of development in order to close their savings and foreign exchange gaps. External3 borrowing is a core element in nearly all developing countries’ development strategies. Foreign loans can be used to finance public spending aimed at increasing growth, development, and security. Debt sustainability and holding the debt burden at a reasonable level are the two main cornerstones of achieving macroeconomic stability. Solvency is derived from the intertemporal budget constraint which shows sustainability of current policies. Generally, when the expected value of the future resources devoted to debt service equals the current debt stock, solvency condition is satisfied. Developing countries\\' debt is external debt incurred by Third World countries, generally in quantities beyond that country\\'s ability to repay. Unpayable debt is a term used to describe external debt where the interest on the debt exceeds the amount that the country produces, thus preventing the debt ever being repaid. IMF’ policies through to the World Economy have been changed in the globalization processes. Those policies have been applied in different countries When Turkish economy is taken into consideration it is seen that; it has high debt stocks, the need of external debt continues to increase and the external debt indicators give rise to the anxieties about the issue of external debt sustainability. This paper responds to take forward on external debt-related vulnerabilities and balance sheet risks.

  16. Domino Synthesis of Thiochromenes through Cu-Catalyzed Incorporation of Sulfur Using Xanthate Surrogate.

    Science.gov (United States)

    Muthupandi, Pandi; Sundaravelu, Nallappan; Sekar, Govindasamy

    2017-02-17

    An efficient domino reaction has been developed for the synthesis of thiochromenes through Cu-catalyzed in situ incorporation of sulfur. This domino method avoids the use of less accessible and unpleasant arenethiols as starting materials, instead utilizes very stable aryl halides along with potassium ethyl xanthate as an odorless sulfur surrogate. The domino methodology proceeds through C(aryl)-S coupling, thioester cleavage, sulfa-Michael addition, aldol reaction, and elimination reaction sequences to provide thiochromenes in good yields.

  17. Effects of Differences in Suggestibility within Self- and External-Control Conditions.

    Science.gov (United States)

    Souheaver, Gary T.; Schuldt, W. John

    1978-01-01

    Studied effects of suggestibility on performance within self- and external-control conditions. Subjects were assigned to experimental conditions--self-control, external-control, and no reward. Response rates of self and external groups were highest. Response rates of high-suggestibles in self-control conditions were not significantly different…

  18. Cost-effectiveness of automated external defibrillators on airlines.

    Science.gov (United States)

    Groeneveld, P W; Kwong, J L; Liu, Y; Rodriguez, A J; Jones, M P; Sanders, G D; Garber, A M

    2001-09-26

    Installation of automated external defibrillators (AEDs) on passenger aircraft has been shown to improve survival of cardiac arrest in that setting, but the cost-effectiveness of such measures has not been proven. To examine the costs and effectiveness of several different options for AED deployment in the US commercial air transportation system. Decision and cost-effectiveness analysis of a strategy of full deployment on all aircraft as well as several strategies of partial deployment only on larger aircraft, compared with a baseline strategy of no AEDs on aircraft (but training flight attendants in basic life support) for a hypothetical cohort of persons experiencing cardiac arrest aboard US commercial aircraft. Estimates for costs and outcomes were obtained from the medical literature, the Federal Aviation Administration, the Air Transport Association of America, a population-based cohort of Medicare patients, AED manufacturers, and the Bureau of Labor Statistics. Quality-adjusted survival after cardiac arrest; costs of AED deployment on aircraft and of medical care for cardiac arrest survivors. Adding AEDs on passenger aircraft with more than 200 passengers would cost $35 300 per quality-adjusted life-year (QALY) gained. Additional AEDs on aircraft with capacities between 100 and 200 persons would cost an additional $40 800 per added QALY compared with deployment on large-capacity aircraft only, and full deployment on all passenger aircraft would cost an additional $94 700 per QALY gained compared with limited deployment on aircraft with capacity greater than 100. Sensitivity analyses indicated that the quality of life, annual mortality rate, and the effectiveness of AEDs in improving survival were the most influential factors in the model. In 85% of Monte Carlo simulations, AED placement on large-capacity aircraft produced cost-effectiveness ratios of less than $50 000 per QALY. The cost-effectiveness of placing AEDs on commercial aircraft compares favorably

  19. Assessment of environmental external effects in the production of energy

    DEFF Research Database (Denmark)

    Schleisner, L.; Meyer, H.J.; Morthorst, P.E.

    1995-01-01

    A project in Denmark has been carried out with the purpose to assess the environmental damages and the external costs in the production of energy. The energy production technologies that will be reported in this paper are wind power and a conventional coal fired plant. In the project...... the environmental damages for the energy production technologies are compared, and externalities in the production of energy using renewable energy and fossil fuels are identified, estimated and monetized....

  20. Successful Domino Liver Transplantation from a Patient with Methylmalonic Acidemia.

    Science.gov (United States)

    Khanna, A; Gish, R; Winter, S C; Nyhan, W L; Barshop, B A

    2016-01-01

    Liver transplantation has been reported in patients with methylmalonic acidemia (MMA), but long-term outcome is controversial. Many patients with other approved indications for liver transplantation die before donor grafts are available. A 28-year-old man with MMA underwent cadaveric liver transplantation. His liver was used as a domino graft for a 61-year-old man with primary sclerosing cholangitis, who had low priority on the transplant waiting list. Surgical outcome was successful, and after transplantation both patients have excellent graft function. The patient with MMA showed substantial decrease in methylmalonate in urine (from 5,277 ± 1,968 preoperatively to 1,068 ± 384 mmol/mol creatinine) and plasma (from 445.9 ± 257.0 to 333.3 ± 117.7 μmol/l) over >1-year follow-up, while dietary protein intake increased from 0.6 to 1.36 ± 0.33 g/kg/day. The domino recipient maintained near-normal levels of plasma amino acids but did develop elevated methylmalonate in blood and urine while receiving an unrestricted diet (peak plasma methylmalonate 119 μmol/l and urine methylmalonate 84-209 mmol/mol creatinine, with 1.0-1.9 g/kg/day protein). Neither patient demonstrated any apparent symptoms of MMA or metabolic decompensation during the postoperative period or following discharge. Liver transplantation substantially corrects methylmalonate metabolism in MMA and greatly attenuates the disease. In this single patient experience, a liver from a patient with MMA functioned well as domino graft although it did result in subclinical methylmalonic acidemia and aciduria in the recipient. Patients with MMA can be considered as domino liver donors for patients who might otherwise spend long times waiting for liver transplantation.

  1. Flexible synthesis of anthracycline aglycone mimics via domino carbopalladation reactions

    Directory of Open Access Journals (Sweden)

    Markus Leibeling

    2013-10-01

    Full Text Available A synthesis of anthracycline aglycone derivatives is described. The key step utilizes a powerful domino carbopalladation approach and subsequent ring closure. During this process two of the four rings of the anthracycline scaffold are formed. Differently substituted carbohydrates and dialkyne chains serve as versatile and simple starting materials for the reaction sequence. Diverse building blocks lead to a variety of different products and a broad range of structural diversity.

  2. Environmental external effects for wind power and coal

    Energy Technology Data Exchange (ETDEWEB)

    Schleisner, L.; Meyer, H.J.; Morthorst, P.E. [Risoe National Lab., Roskilde (Denmark). Systems Analysis Dept.

    1995-12-31

    This article summarises some of the results achieved in a project carried out in Denmark with the purpose to assess the environmental damages and the external costs in the production of energy. The project has especially handled renewable energy versus energy based on fossil fuels. The project has been a collaboration between the Technical University of Denmark and Riso National Laboratory. The research institutions have considered different energy production technologies in the project. The energy production technologies that have been considered by Risoe National Laboratory and will be reported and compared in this article are the following: (1) Wind power, (2) A coal-fired condensing plant. In the project the environmental damages are thus compared, and externalities in the production of energy using renewable energy and fossil fuels are identified, estimated and monetized. The following result applies in general to the applied technologies. Only the environmental externalities have been assessed in the project. Social and economical externalities, e.g. related to changes in employment or depletion of resources, are not included in the project. The cost concept is based on marginal damage cost, in principle taking as starting point the level of pollution that exists today. The methodology, which has been used in order to find and monetize the environmental externalities, consists of the different processes like Identification, quantification, Dose-response and Valuation

  3. 'Domino' systems biology and the 'A' of ATP.

    Science.gov (United States)

    Verma, Malkhey; Zakhartsev, Maksim; Reuss, Matthias; Westerhoff, Hans V

    2013-01-01

    We develop a strategic 'domino' approach that starts with one key feature of cell function and the main process providing for it, and then adds additional processes and components only as necessary to explain provoked experimental observations. The approach is here applied to the energy metabolism of yeast in a glucose limited chemostat, subjected to a sudden increase in glucose. The puzzles addressed include (i) the lack of increase in adenosine triphosphate (ATP) upon glucose addition, (ii) the lack of increase in adenosine diphosphate (ADP) when ATP is hydrolyzed, and (iii) the rapid disappearance of the 'A' (adenine) moiety of ATP. Neither the incorporation of nucleotides into new biomass, nor steady de novo synthesis of adenosine monophosphate (AMP) explains. Cycling of the 'A' moiety accelerates when the cell's energy state is endangered, another essential domino among the seven required for understanding of the experimental observations. This new domino analysis shows how strategic experimental design and observations in tandem with theory and modeling may identify and resolve important paradoxes. It also highlights the hitherto unexpected role of the 'A' component of ATP. Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved.

  4. Assessment of Environmental External Effects in Power Generation

    DEFF Research Database (Denmark)

    Meyer, Henrik Jacob; Morthorst, Poul Erik; Ibsen, Liselotte Schleisner

    1996-01-01

    to the production of electricity based on a coal fired conventional plant. In the second case heat/power generation by means of a combined heat and power plant based on biomass-generated gas is compared to that of a combined heat and power plant fuelled by natural gas.In the report the individual externalities from...... technologies. The report compares environmental externalities in the production of energy using renewable and non-renewable energy sources, respectively. The comparison is demonstrated on two specific case studies. The first case is the production of electricity based on wind power plants compared...

  5. Evaluating Effectiveness of External Auditors’ Report: Empirical Evidence from Iran

    Directory of Open Access Journals (Sweden)

    Mahdi Salehi

    Full Text Available This study emphasizes that it is interesting to study the opinion of the auditor as intermediary information between the company and external users throughout audit report. Throughout questionnaire usable data were collected from different participants. The results of this study show that audit report is easily understandable from various stakeholders in Iran and it is cornerstone to investment making decision.

  6. Domino logic designs for high-performance and leakage-tolerant applications

    DEFF Research Database (Denmark)

    Moradi, Farshad; Vu Cao, Tuan; Vatajelu, Elena Ioana;

    2013-01-01

    Robustness of high fan-in domino circuits is degraded by technology scaling due to exponential increase in leakage. In this paper, we propose several domino logic circuit techniques to improve the robustness and performance along with leakage power. Lower total power consumption is achieved by ut...

  7. Individual Cognitive Structuring and the Sociocultural Context: Strategy Shifts in the Game of Dominoes

    Science.gov (United States)

    Nasir, Na'ilah Suad

    2005-01-01

    In this article, I explore the relation between the sociocultural and individual cognitive structuring as elementary school students, high school students, and adults play the strategic game of dominoes. I present data from a study in which players at each level were observed and video-recorded during domino tournament play. Findings reveal the…

  8. Domino/Notes安全机制及网状安全设计研究

    Institute of Scientific and Technical Information of China (English)

    孙健

    2001-01-01

    介绍了Domino/Notes校验与认证、存取控制等数种安全机制、针对Domino/Notes安全设计理论的空白,提出了网状安全设计的思想,详细介绍了设计步骤,并用实例辅以说明

  9. Design of ternary low-power Domino JKL flip-flop and its application

    Institute of Scientific and Technical Information of China (English)

    Wang Pengjun; Yang Qiankun; Zheng Xuesong

    2012-01-01

    By researching the ternary flip-flop and the adiabatic Domino circuit,a novel design of low-power ternary Domino JKL flip-flop on the switch level is proposed.First,the switch-level structure of the ternary adiabatic Domino JKL flip-flop is derived according to the switch-signal theory and its truth table.Then the ternary loop operation circuit and ternary reverse loop operation circuit are achieved by employing the ternary JKL flip-flop.Finally,the circuit is simulated by using the Spice tool and the results show that the logic function is correct.The energy consumption of the ternary adiabatic Domino JKL flip-flop is 69% less than its conventional Domino counterpart.

  10. Effects of external fields, dimension and polarization on the resonance fluorescence of quantum dots

    Energy Technology Data Exchange (ETDEWEB)

    Vaseghi, B., E-mail: vaseghi@mail.yu.ac.ir; Razavi, S.M.

    2017-02-01

    In this paper simultaneous effects of external electric and magnetic fields, dimension and polarization on the resonance fluorescence spectrum and photon statistics of a spherical quantum dot with parabolic confinement are investigated. With special attention to the optical scattering processes resonance fluorescence spectrum and second-order correlation function are calculated and plotted for different external parameters. Our results show the occurrence of resonance fluorescence similar to atomic systems and considerable effects of external fields, quantum confinement and light polarization on the resonance fluorescence spectrum and second-order correlation function in the quantum dot systems. The existence of Mollow triplets and photon antibunching are strongly depend on these external agents.

  11. Effects of external fields, dimension and polarization on the resonance fluorescence of quantum dots

    Science.gov (United States)

    Vaseghi, B.; Razavi, S. M.

    2017-02-01

    In this paper simultaneous effects of external electric and magnetic fields, dimension and polarization on the resonance fluorescence spectrum and photon statistics of a spherical quantum dot with parabolic confinement are investigated. With special attention to the optical scattering processes resonance fluorescence spectrum and second-order correlation function are calculated and plotted for different external parameters. Our results show the occurrence of resonance fluorescence similar to atomic systems and considerable effects of external fields, quantum confinement and light polarization on the resonance fluorescence spectrum and second-order correlation function in the quantum dot systems. The existence of Mollow triplets and photon antibunching are strongly depend on these external agents.

  12. Lotus Domino/Notes的安全机制的剖析及应用%An Analysis and Application of the Safety Mechanism of "Lotus Domino/Notes"

    Institute of Scientific and Technical Information of China (English)

    武坤; 徐刚

    2002-01-01

    随着社会竞争的加剧,各行各业对数据的安全性的要求越来越高.而Lotus Domino/Notes由于它在数据库方面的独特的优势,使用越来越广.为了让人们了解Lotus Domino/Notes的安全机制,本文通过对Domino/Notes数据库安全需求的分析,向读者剖析了Lotus Domino/Notes安全机制,以便用户在开发信息系统时能合适选择所需的安全机制的组件,同时阐述了安全机制的应用.

  13. Creating Domino Web Sites Using HTML Authoring Tools%用HTML编写工具和Domino Designer结合开发Web站点

    Institute of Scientific and Technical Information of China (English)

    袁亦韧

    2001-01-01

    用HTML编写工具和Domino Designer结合可以便捷地设计出既美观、又有价值的商用Web站点.介绍了Lotus公司提供的组件DDC与DIS.并用一个实例来说明如何利用它来结合Web站点编写工具建立Domino Web站点.

  14. The Effect of Fatigued External Rotator Muscles of the Shoulder on the Shoulder Position Sense

    OpenAIRE

    Naoya Iida; Fuminari Kaneko; Nobuhiro Aoki; Yoshinari Sakaki

    2011-01-01

    This study aimed to investigate the effect of fatigue in shoulder external rotator muscles on position sense of shoulder abduction, internal rotation, and external rotation. The study included 10 healthy subjects. Shoulder position sense was measured before and after a fatigue task involving shoulder external rotator muscles. The fatigue task was performed using an isokinetic machine. To confirm the muscle fatigue, electromyography (EMG) was recorded, and an integrated EMG and median power fr...

  15. Investigating the effect of externalizing perspectives on cognitives biases

    DEFF Research Database (Denmark)

    Madsen, Fredrik Huitfeldt; Hicks, David L., David

    2007-01-01

    the number of attacks that “get through”. There are many subproblems of this main problem, one of which is that relative quality of the intelligence analysis is too low [39, We observe that the analysts suffer from cognitive biases, and we assume that this is one of the reasons behind “low” quality...... of intelligence analysis. We propose that complexity of maintaining multiple different perspectives the same data is one of the reasons for this. We further propose that a tool that facillitates the externalization multiple perspectives would reduce these biases and hence increase the overall quality...

  16. A domino palladium-catalyzed C-C and C-O bonds formation via dual O-H bond activation: synthesis of 6,6-dialkyl-6H-benzo[c]chromenes.

    Science.gov (United States)

    Mahendar, Lodi; Krishna, Jonnada; Reddy, Alavala Gopi Krishna; Ramulu, Bokka Venkat; Satyanarayana, Gedu

    2012-01-20

    An efficient Pd-catalyzed domino reaction of α,α-dialkyl-(2-bromoaryl)methanols to 6,6-dialkyl-6H-benzo[c]chromenes is presented. Their formation can be explained via a five membered Pd(II)-cycle that efficiently involves a domino homocoupling with the second molecule, β-carbon cleavage, and finally intramolecular Buchwald-Hartwig cyclization. This domino process effectively involves breaking of five σ-bonds (2C-Br, 2O-H, and a C-C) and formation of two new σ-bonds (C-C and C-O). This mechanistic pathway is unprecedented and further illustrates the power of transition metal catalysis.

  17. The strategic Samaritan : How effectiveness and proximity affect corporate responses to external crises

    NARCIS (Netherlands)

    Jordan, Jennifer; Diermeier, Daniel A.; Galinsky, Adam D.

    2012-01-01

    This research examines how two dimensions of moral intensity involved in a corporation's external crisis response-magnitude of effectiveness and interpersonal proximity-influence observer perceptions of and behavioral intentions toward the corporation. Across three studies, effectiveness decreased n

  18. The strategic Samaritan : How effectiveness and proximity affect corporate responses to external crises

    NARCIS (Netherlands)

    Jordan, Jennifer; Diermeier, Daniel A.; Galinsky, Adam D.

    2012-01-01

    This research examines how two dimensions of moral intensity involved in a corporation's external crisis response-magnitude of effectiveness and interpersonal proximity-influence observer perceptions of and behavioral intentions toward the corporation. Across three studies, effectiveness decreased

  19. The additive and interactive effects of parenting and children's personality on externalizing behaviour

    NARCIS (Netherlands)

    Prinzie, P; Onghena, P; Hellinckx, W; Grietens, H; Ghesquiere, P; Colpin, H

    2003-01-01

    Parenting practices have been previously linked to childhood externalizing behaviour However little attention has been given to the potential effect of individual personality differences among children on this relation. The current study assesses the additive effects of children's personality charac

  20. Scientific Team Effectiveness and the External CEO: A Study of Biotechnology University Spin-Offs

    Science.gov (United States)

    van der Steen, Marianne; Englis, Paula Danskin; Englis, Basil G.

    2013-01-01

    This paper presents an empirical exploration of the effectiveness of scientific teams and the role of an external CEO in the spin-off formation process. The paper contributes to the literature by focusing on the role of the experienced or "external" entrepreneur (their commercial resources and capabilities) in the early phase of spin-off…

  1. Scientific team effectiveness and the external CEO: A study of biotechnology university spin-offs

    NARCIS (Netherlands)

    Steen, van der M.; Danskin Englis, P.; Englis, B.G.

    2013-01-01

    This paper presents an empirical exploration of the effectiveness of scientific teams and the role of an external CEO in the spin-off formation process. The paper contributes to the literature by focusing on the role of the experienced or 'external' entrepreneur (their commercial resources and capab

  2. Torsional Detwinning Domino in Nanotwinned One-Dimensional Nanostructures.

    Science.gov (United States)

    Zhou, Haofei; Li, Xiaoyan; Wang, Ying; Liu, Zishun; Yang, Wei; Gao, Huajian

    2015-09-09

    How to maintain sustained deformation in one-dimensional nanostructures without localized failure is an important question for many applications of nanotechnology. Here we report a phenomenon of torsional detwinning domino that leads to giant rotational deformation without localized failure in nanotwinned one-dimensional metallic nanostructures. This mechanism is demonstrated in nanotwinned Cu nanorods via molecular dynamics simulations, where coherent twin boundaries are transformed into twist boundaries and then dissolved one by one, resulting in practically unlimited rotational deformation. This finding represents a fundamental advance in our understanding of deformation mechanisms in one-dimensional metallic nanostructures.

  3. Domino shuffling for the Del Pezzo 3 lattice

    CERN Document Server

    Cottrell, Cyndie

    2010-01-01

    We present a version of the domino shuffling algorithm (due to Elkies, Kuperberg, Larsen and Propp) which works on a different lattice: the hexagonal lattice superimposed on its dual graph. We use our algorithm to count perfect matchings on a family of finite subgraphs of this lattice whose boundary conditions are compatible with our algorithm. In particular, we re-prove an enumerative theorem of Ciucu, as well as finding a related family of subgraphs which have 2^{(n+1)^2} perfect matchings. We also give three-variable generating functions for perfect matchings on both families of graphs, which encode certain statistics on the height functions of these graphs.

  4. High-speed dynamic domino circuit implemented with gaas mesfets

    Science.gov (United States)

    Yang, Long (Inventor); Long, Stephen I. (Inventor)

    1990-01-01

    A dynamic logic circuit (AND or OR) utilizes one depletion-mode metal-semiconductor FET for precharging an internal node A, and a plurality of the same type of FETs in series, or a FET in parallel with one or more of the series connected FETs for implementing the logic function. A pair of FETs are connected to provide an output inverter with two series diodes for level shift. A coupling capacitor may be employed with a further FET to provide level shifting required between the inverter and the logic circuit output terminal. These circuits may be cascaded to form a domino chain.

  5. The assessment of the damage probability of storage tanks in domino events triggered by fire.

    Science.gov (United States)

    Landucci, Gabriele; Gubinelli, Gianfilippo; Antonioni, Giacomo; Cozzani, Valerio

    2009-11-01

    An approach aimed to the quantitative assessment of the risk caused by escalation scenarios triggered by fire was developed. Simplified models for the estimation of the vessel time to failure (ttf) with respect to the radiation intensity on the vessel shell were obtained using a multi-level approach to the analysis of vessel wall failure under different fire conditions. Each vessel "time to failure" calculated by this approach for the specific fire scenario of concern was compared to a reference time required for effective mitigation actions and related to the escalation probability. The failure probability of each vessel was correlated to the probability of scenarios involving multiple vessel failure as a consequence of the primary fire, thus allowing a comprehensive assessment of domino scenarios triggered by fire. The application of the methodology to the analysis of several case-studies allowed the estimation of the quantitative contribution of escalation events triggered by fire to the overall individual and societal risk indexes.

  6. Leaky domino-modes in regular arrays of substantially thick metal nanostrips

    Science.gov (United States)

    Voroshilov, Pavel M.; Simovski, Constantin R.

    2016-07-01

    In previous works, an efficient light trapping performed by arrays of metal nanoantennas whose building block was a slightly tapered (trapezoidal) substantially thick nanostrip was revealed. This light trapping implied a broad spectrum of solar light concentrated in a subwavelength depth of the semiconductor substrate. This is a very advantageous feature allowing our structure to enhance thin-film solar cells. However, the physics of the broadband resonant absorption in the substrate was not investigated. In the present paper, we show that our arrays support so-called leaky domino-modes, responsible for such the light trapping. These modes are multipole oscillations of the array of substantially thick nanostrips. In this work we have thoroughly studied these leaky modes relating them to resonances of high-order multipole moments and to broadband light-trapping effect.

  7. 3D replicon distributions arise from stochastic initiation and domino-like DNA replication progression.

    Science.gov (United States)

    Löb, D; Lengert, N; Chagin, V O; Reinhart, M; Casas-Delucchi, C S; Cardoso, M C; Drossel, B

    2016-04-07

    DNA replication dynamics in cells from higher eukaryotes follows very complex but highly efficient mechanisms. However, the principles behind initiation of potential replication origins and emergence of typical patterns of nuclear replication sites remain unclear. Here, we propose a comprehensive model of DNA replication in human cells that is based on stochastic, proximity-induced replication initiation. Critical model features are: spontaneous stochastic firing of individual origins in euchromatin and facultative heterochromatin, inhibition of firing at distances below the size of chromatin loops and a domino-like effect by which replication forks induce firing of nearby origins. The model reproduces the empirical temporal and chromatin-related properties of DNA replication in human cells. We advance the one-dimensional DNA replication model to a spatial model by taking into account chromatin folding in the nucleus, and we are able to reproduce the spatial and temporal characteristics of the replication foci distribution throughout S-phase.

  8. Drosophila domino Exhibits Genetic Interactions with a Wide Spectrum of Chromatin Protein-Encoding Loci.

    Science.gov (United States)

    Ellis, Kaitlyn; Friedman, Chloe; Yedvobnick, Barry

    2015-01-01

    The Drosophila domino gene encodes protein of the SWI2/SNF2 family that has widespread roles in transcription, replication, recombination and DNA repair. Here, the potential relationship of Domino protein to other chromatin-associated proteins has been investigated through a genetic interaction analysis. We scored for genetic modification of a domino wing margin phenotype through coexpression of RNAi directed against a set of previously characterized and more newly characterized chromatin-encoding loci. A set of other SWI2/SNF2 loci were also assayed for interaction with domino. Our results show that the majority of tested loci exhibit synergistic enhancement or suppression of the domino wing phenotype. Therefore, depression in domino function sensitizes the wing margin to alterations in the activity of numerous chromatin components. In several cases the genetic interactions are associated with changes in the level of cell death measured across the dorsal-ventral margin of the wing imaginal disc. These results highlight the broad realms of action of many chromatin proteins and suggest significant overlap with Domino function in fundamental cell processes, including cell proliferation, cell death and cell signaling.

  9. Early renal failure after domino liver transplantation using organs from donors with primary hyperoxaluria type 1.

    Science.gov (United States)

    Saner, Fuat H; Treckmann, Juergen; Pratschke, Johann; Arbogast, Helmut; Rahmel, Axel; Vester, Udo; Paul, Andreas

    2010-10-15

    Organ shortage is responsible for high mortality rates of patients awaiting liver transplantation (LT). Domino transplantation has had reported success in patients with metabolic disorders. Primary hyperoxaluria type 1 (PH1) is a rare metabolic disorder. There are a few case reports that suggest that PH1 livers originating from donors that have undergone combined liver-kidney transplantation can be successfully used for domino transplantation. In the last decade, five patients received a domino liver transplant from patients with PH1 in the EUROTRANSPLANT region. In this study, we report the clinical course and outcome of these five patients who were received a domino graft transplant. All patients, with the exception of one, suffered from multifocal hepatocellular carcinoma and underwent domino LT from patients undergoing combined liver-kidney transplantation for PH1. Within the first 4 weeks, all the domino recipients developed dialysis-dependent kidney failure despite good liver function. Four of the five patients died. The only survivor underwent retransplantation due to hepatic artery thrombosis. Twenty months after transplantation, this patient is doing well and has had no recurrence of hepatocellular carcinoma. Domino LT using donors with PH1 results in early renal failure and cannot be recommended for transplantation unless preventive strategies have been identified.

  10. Effects of Oil Price, External Debt and Population on the Government Investment in Syria

    Directory of Open Access Journals (Sweden)

    Adel Shakeeb Mohsen

    2015-03-01

    Full Text Available This study attempts to investigate the effect of oil price, external debt and population on the government investment in Syria over the period 1970-2010. The Johansen cointegration test showed that oil price, external debt and population have a positive and significant long run relationship with government investment. The Granger causality test indicates bidirectional long-run causality relationships between oil price, external debt, population, and government investment. There are also unidirectional short-run causality relationships running from oil price and population to government investment, and bidirectional short-run causality relationship between external debt and government investment. The study result indicates that, external debt have the biggest effect on the government investment, as well as oil price and population can play an important role in supporting the government investment in the country.

  11. Handling magnetic anisotropy and magnetoimpedance effect in flexible multilayers under external stress

    Science.gov (United States)

    Agra, K.; Bohn, F.; Mori, T. J. A.; Callegari, G. L.; Dorneles, L. S.; Correa, M. A.

    2016-12-01

    We investigate the dynamic magnetic response though magnetoimpedance effect of ferromagnetic flexible NiFe/Ta and FeCuNbSiB/Ta multilayers under external stress. We explore the possibility of handling magnetic anisotropy, and consequently the magnetoimpedance effect, of magnetostrictive multilayers deposited onto flexible substrates. We quantify the sensitivity of the multilayers under external stress by calculating the ratio between impedance variations and external stress changes, and show that considerable values can be reached by tuning the magnetic field, frequency, magnetostriction constant, and external stress. The results extend possibilities of application of magnetostrictive multilayers deposited onto flexible substrates when under external stress and place them as very attractive candidates as element sensor for the development of sensitive smart touch sensors.

  12. DOIND: a technique for leakage reduction in nanoscale domino logic circuits

    Science.gov (United States)

    Prasad Shah, Ambika; Neema, Vaibhav; Daulatabad, Shreeniwas

    2016-05-01

    A novel DOIND logic approach is proposed for domino logic, which reduces the leakage current with a minimum delay penalty. Simulation is performed at 70 nm technology node with supply voltage 1V for domino logic and DOIND logic based AND, OR, XOR and Half Adder circuits using the tanner EDA tool. Simulation results show that the proposed DOIND approach decreases the average leakage current by 68.83%, 66.6%, 77.86% and 74.34% for 2 input AND, OR, XOR and Half Adder respectively. The proposed approach also has 47.76% improvement in PDAP for the buffer circuit as compared to domino logic.

  13. Domino logic designs for high-performance and leakage-tolerant applications

    DEFF Research Database (Denmark)

    Moradi, Farshad; Vu Cao, Tuan; Vatajelu, Elena Ioana

    2013-01-01

    Robustness of high fan-in domino circuits is degraded by technology scaling due to exponential increase in leakage. In this paper, we propose several domino logic circuit techniques to improve the robustness and performance along with leakage power. Lower total power consumption is achieved...... by utilizing proposed techniques. According to the simulations in TSMC 65 nm CMOS process, the proposed circuits increase noise immunity for wide OR gates by at least 3.5X and shows performance improvement of up to 20% compared to conventional domino logic circuits. For FinFET simulation TCAD tools have been...

  14. An Analysis of the Effect of External Debt on Crowding-Out of Private ...

    African Journals Online (AJOL)

    An Analysis of the Effect of External Debt on Crowding-Out of Private Investment in Ghana. ... Journal of Business Research ... investment development, through facilitating investment growth by using appropriate macroeconomic policies.

  15. Influence of External Magnetic Field on Anomalous Skin Effects in Inductively Coupled Plasmas

    Institute of Scientific and Technical Information of China (English)

    MAO Ming; WANG You-Nian

    2004-01-01

    @@ Using a one-dimensional slab model, we study the influence of the external static magnetic field on the anomalous skin effects in the inductively coupled plasma. The rf electromagnetic field in the plasma is determined by solving the linearized Boltzmann equation incorporating with the Maxwell equations. The numerical results show that,due to the existence of the external magnetic field, the anomalous skin effects are greatly enhanced and the number of regions with negative absorption is decreased.

  16. Testing Causal Effects of Maternal Smoking During Pregnancy on Offspring's Externalizing and Internalizing Behavior.

    Science.gov (United States)

    Dolan, C V; Geels, L; Vink, J M; van Beijsterveldt, C E M; Neale, M C; Bartels, M; Boomsma, Dorret I

    2016-05-01

    Maternal smoking during pregnancy (SDP) is associated with increased risk of externalizing and internalizing behaviors in offspring. Two explanations (not mutually exclusive) for this association are direct causal effects of maternal SDP and the effects of genetic and environmental factors common to parents and offspring which increase smoking as well as problem behaviors. Here, we examined the associations between parental SDP and mother rated offspring externalizing and internalizing behaviors (rated by the Child Behavior Checklist/2-3) at age three in a population-based sample of Dutch twins (N = 15,228 pairs). First, as a greater effect of maternal than of paternal SDP is consistent with a causal effect of maternal SDP, we compared the effects of maternal and paternal SDP. Second, as a beneficial effect of quitting smoking before pregnancy is consistent with the causal effect, we compared the effects of SDP in mothers who quit smoking before pregnancy, and mothers who continued to smoke during pregnancy. All mothers were established smokers before their pregnancy. The results indicated a greater effect of maternal SDP, compared to paternal SDP, for externalizing, aggression, overactive and withdrawn behavior. Quitting smoking was associated with less externalizing, overactive behavior, aggression, and oppositional behavior, but had no effect on internalizing, anxious depression, or withdrawn behavior. We conclude that these results are consistent with a causal, but small, effect of smoking on externalizing problems at age 3. The results do not support a causal effect of maternal SDP on internalizing behaviors.

  17. Effect of External Optical Feedback for Nano-laser Structures

    DEFF Research Database (Denmark)

    Taghizadeh, Alireza; Mørk, Jesper; Chung, Il-Sug

    2013-01-01

    We theoretically investigated the effect of optical feedback on a photonic crystal nanolaser, comparing with conventional in-plane and vertical-cavity lasers.......We theoretically investigated the effect of optical feedback on a photonic crystal nanolaser, comparing with conventional in-plane and vertical-cavity lasers....

  18. Domino Wittig Diels-Alder reaction: An expeditious entry into the AB ring system of furanosesquiterpenes

    Digital Repository Service at National Institute of Oceanography (India)

    Patre, R.E.; Gawas, S.; Sen, S.; Parameswaran, P.S.; Tilve, S.G.

    A domino Wittig Diels - Alder reaction has been employed in delineating a short and flexible synthetic stratagem for ready access to the AB ring system and the tricyclic framework of furanosesquiterpenes, such as the bioactive natural products...

  19. High-efficiency transition between rectangular waveguide and domino plasmonic waveguide

    Science.gov (United States)

    Liu, Liangliang; Li, Zhuo; Xu, Bingzheng; Gu, Changqing; Chen, Chen; Ning, Pingping; Yan, Jian; Chen, Xingyu

    2015-02-01

    In this work, we propose an optimized transition structure to realize smooth and high efficiency conversion from the guided wave supported by a conventional rectangular waveguide (CRW) to the domino plasmon polaritons (DPPs) supported by a domino plasmonic waveguide (DPW) and vice versa in the X-band (8.2GHz˜12.4GHz). This transition structure consists of two tapered CRWs connected by a gradient domino array with optimized gradient heights and lateral widths. Experimental results of the S-parameters show excellent agreement with the simulations and the optimization scheme can be readily extended to other bands. Furthermore, a domino plasmonic power divider is implemented to demonstrate the application of the transition structure in the integration of conventional microwave circuits with plasmonic devices.

  20. Formation of pentacyclic structures by a domino sequence on cyclic enamides.

    Science.gov (United States)

    Satyanarayana, Gedu; Maichle-Mössmer, Caecilia; Maier, Martin E

    2009-03-28

    Novel spiropentacyclic compounds were obtained from cyclic enamides of type , featuring a (2-bromophenyl)propyl substituent in the 5-position, through a Pd-mediated domino sequence taking place via Heck insertion and C-H activation.

  1. Effects of Potassium Currents upon Action Potential of Cardiac Cells Exposed to External Electric fields

    Institute of Scientific and Technical Information of China (English)

    An-Ying Zhang; Xiao-Feng Pang

    2008-01-01

    Previous studies show that exposure to high-voltage electric fields would influence the electro cardiogram both in experimental animate and human beings. The effects of the external electric fields upon action potential of cardiac cells are studied in this paper based on the dynamical model, LR91. Fourth order Runger-Kuta is used to analyze the change of potassium ion channels exposed to external electric fields in detail. Results indicate that external electric fields could influence the current of potassium ion by adding an induced component voltage on membrane. This phenomenon might be one of the reasons of heart rate anomaly under the high-voltage electric fields.

  2. Noise Effects in the Mode-Locked External Cavity Lasers

    Institute of Scientific and Technical Information of China (English)

    Nuran Dogru; M. Sadettin Ozyazici

    2003-01-01

    Effect of high level of spontaneous and carrier noise on mode-locked hybrid soliton pulse source and relative intensity noise is described. Transform limited pulses are not generated over a wide frequency range because of these noises.

  3. Behind the Resource Domino. Part II: Allocation

    Science.gov (United States)

    Thiemann, F. C.; Bumbarger, C. S.

    1972-01-01

    Discusses the problem of allocation and acquisition of resources from an administrative point of view. Suggests that an administrator's accountability as a leader is fixed in how efficiently and effectively resources are deployed in the organizational goal attainment efforts. (Author/DN)

  4. Behind the Resource Domino. Part II: Allocation

    Science.gov (United States)

    Thiemann, F. C.; Bumbarger, C. S.

    1972-01-01

    Discusses the problem of allocation and acquisition of resources from an administrative point of view. Suggests that an administrator's accountability as a leader is fixed in how efficiently and effectively resources are deployed in the organizational goal attainment efforts. (Author/DN)

  5. Asymmetric Synthesis of Functionalized Tricyclic Chromanes via an Organocatalytic Triple Domino Reaction.

    Science.gov (United States)

    Kumar, Mukesh; Chauhan, Pankaj; Valkonen, Arto; Rissanen, Kari; Enders, Dieter

    2017-06-02

    A highly stereoselective triple domino reaction for the synthesis of functionalized tricyclic chromane scaffolds has been developed. A secondary amine-catalyzed domino Michael/Michael/aldol condensation reaction between aliphatic aldehydes, nitro-chromenes, and α,β-unsaturated aldehydes leads to the formation of synthetically important tricyclic chromanes bearing four contiguous stereogenic centers including a tetrasubstituted carbon in good yields (20-66%) and excellent stereoselectivities (>20:1 dr and >99% ee).

  6. Domino Staudinger/aza-Wittig/Mannich Reaction: An Approach to Diversity of Di- and Tetrahydropyrrole Scaffolds.

    Science.gov (United States)

    Pavlova, Anna S; Ivanova, Olga A; Chagarovskiy, Alexey O; Stebunov, Nikolay S; Orlov, Nikolay V; Shumsky, Alexey N; Budynina, Ekaterina M; Rybakov, Victor B; Trushkov, Igor V

    2016-12-12

    A highly efficient and selective domino reaction producing valuable di- and tetrahydropyrrole-based skeletons from azidoethyl-substituted CH-acids and (thio)carbonyl compounds has been developed. By involving the additional functional groups in starting compounds into the domino reaction or postmodification of the primary reaction products, the simple construction of the pharmaceutically relevant three- and polycyclic azaheterocyclic scaffolds was demonstrated. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  7. Novel domino procedures for the synthesis of chromene derivatives and their isomerization.

    Science.gov (United States)

    Zonouzi, Afsaneh; Izakian, Zakieh; Ng, Seik Weng

    2016-08-01

    Novel tricyclic keto diesters have been synthesized by a one-pot three-component procedure via DABCO-catalyzed domino Knoevenagel-Michael addition reactions. Also, an efficient four-component reaction for the synthesis of another new group of tricyclic keto diesters has been developed via domino Knoevenagel-intramolecular oxo-Diels-Alder reactions. A selective thermal isomerization of the synthesized chromenes to fumarates is also described. X-ray analyses confirm unambiguously the structures of the products.

  8. Three-level description of the domino cellular automaton

    CERN Document Server

    Czechowski, Zbigniew

    2010-01-01

    Inspired by the approach of kinetic theory of gases, a three-level description (microscopic, mesoscopic and macroscopic) of cellular automaton is presented. To provide an analytical treatment a simple domino cellular automaton with avalanches was constructed. Formulas concerning exact relations for density, clusters, avalanches and other parameters in an equilibrium state were derived. It appears that some relations are approximately valid for deviations from the equilibrium, so the adequate Ito equation could be constructed. The equation provides the time evolution description of some variable on the macroscopic level. The results also suggest a motive for applying of the procedure of construction of the Ito equation (from time series data) to natural time series.

  9. Effects of Internal and External Hydrogen on Inconel 718

    Science.gov (United States)

    Walter, R. J.; Frandsen, J. D.

    1999-01-01

    Internal hydrogen embrittlement (IHE) and hydrogen environment embrittlement (HEE) tensile and bend crack growth tests were performed on Inconel 718. For the IHE tests, the specimens were precharged to approximately 90 ppm hydrogen by exposure to 34.5 MPa H2 at 650 C. The HEE tests were performed in 34.5 MPa H2. Parameters evaluated were test temperature, strain rate for smooth and notch specimen geometries. The strain rate effect was very significant at ambient temperature for both IHE and HEE and decreased with increasing temperatures. For IHE, the strain rate effect was neglible at 260'C, and for HEE the strain rate effect was neglible at 400 C. At low temperatures, IHE was more severe than HEE, and at high temperatures HEE was more severe than IHE with a cross over temperature about 350 C. At 350 C, the equilibrium hydrogen concentration in Inconel 718 is about 50% lower than the hydrogen content of the precharged IHE specimens. Dislocation hydrogen sweeping of surface absorbed hydrogen was the likely transport mechanism for increasing the hydrogen concentration in the HEE tests sufficiently to produce the same degree of embrittlement as that of the more highly hydrogen charged IHE specimens. The main IHE fracture characteristic was formation of large, brittle flat facets, which decreased with increasing test temperature. The IHE fracture matrix surrounding the large facets ranged between brittle fine faceted to microvoid ductility depending upon strain rate, specimen geometry as well as temperature. The HEE fractures were characteristically fine featured, transgranular and brittle with a significant portion forming a "saw tooth" crystallographic pattern. Both IHE and HEE fractures were predominantly along the {1 1 1) slip and twin boundaries. With respect to embrittlement mechanism, it was postulated that dislocation hydrogen sweeping and hydrogen enhanced localized plasticity were active in HEE and IHE for concentrating hydrogen along (1 1 1) slip and twin

  10. Effects of high external electric fields on protein conformation

    Science.gov (United States)

    Pompa, Pier Paolo; Bramanti, Alessandro; Maruccio, Giuseppe; del Mercato, Loretta Laureana; Chiuri, Rocco; Cingolani, Roberto; Rinaldi, Ross

    2005-06-01

    Resistance of biomolecules to high electric fields is a main concern for nanobioelectronics/nanobiosensing applications, and it is also a relevant issue from a fundamental perspective, to understand the dielectric properties and structural dynamics of proteins. In nanoscale devices, biomolecules may experience electric fields as high as 107 V/m in order to elicit charge transport/transfer. Understanding the effects of such fields on their structural integrity is thus crucial to assess the reliability of biomolecular devices. In this study, we show experimental evidence for the retention of native-like fold pattern by proteins embedded in high electric fields. We have tested the metalloprotein azurin, deposited onto SiO2 substrates in air with proper electrode configuration, by applying high static electric fields (up to 106-107 V/m). The effects on the conformational properties of protein molecules have been determined by means of intrinsic fluorescence measurements. Experimental results indicate that no significant field-induced conformational alteration occurs. This behavior is also discussed and supported by theoretical predictions of the intrinsic intra-protein electric fields. As the general features of such inner fields are not peculiar of azurin, the conclusions presented here should have general validity.

  11. XML在Domino环境中异构数据交换技术应用%Application of XML Technology on Heterogeneous Data Exchange in Domino Environment

    Institute of Scientific and Technical Information of China (English)

    张正做; 周霖

    2013-01-01

      To effectively solve the problem of heterogeneous data integration between the drug testing management system and other systems, introduces the principle of data change using XML in Lotus Domino platform, and particularly discusses the technology of drug information exchange under the environment of Lotus Domino platform based on the XML technology. Obtains a conclusion that the corresponding application system will be flexibility and portability if uses the technology of XML for heterogeneous data change.%  为了解决本院药品检验系统中内部数据与外部数据集成问题,概括介绍利用XML在Lotus Domino 环境中进行数据交换的原理,并详细讨论在Lotus Domino环境中利用XML 实现检品信息交换的技术,得出结论在Lotus Domino环境中利用XML进行异构数据交换为应用系统带来更大的灵活性。

  12. Lithium chloride-mediated stereoselective synthesis of cyclopropanecarboxamides from γ,δ-epoxy malonates through a domino cyclopropanation/lactonization/aminolysis process.

    Science.gov (United States)

    Marques, Marcelo V; Sá, Marcus M

    2014-05-16

    The stereoselective synthesis of novel multifunctionalized cyclopropanes from γ,δ-epoxy malonates and amines mediated by LiCl under mild conditions was carried out. This domino reaction involves the initial cyclopropanation via intramolecular ring-opening of γ,δ-epoxy malonates through the cooperative catalysis of LiCl (acting as a Lewis acid) and a Brønsted base (a primary or, in selected cases, a secondary amine). The sequential events consisted of lactonization and aminolysis of the lactone ring, which ultimately furnished cyclopropanecarboxamides with different substitution patterns in good isolated yields. In all cases, a quaternary stereogenic center could be perfectly assembled, with a single diastereoisomer being obtained. This method proceeds with high atom economy, is remarkably modular and operationally simple, and tolerates a variety of functional groups. The involvement of readily available starting materials, the broad scope, and the use of a sustainable solvent (methanol or ethanol) at ambient temperature make this domino process highly effective. A reaction mechanism is proposed on the basis of the experimental observations involving the preparation and reactivity of cyclopropylidene lactones as possible intermediates of the domino process.

  13. Understanding the domino retro [3+2] cycloaddition/cyclization reaction of bicyclic isoxazolidines in the synthesis of spirocyclic alkaloids. A DFT study.

    Science.gov (United States)

    Layeb, Hatem; Nacereddine, Abdelmalek Khorief; Djerourou, Abdelhafid; Domingo, Luis R

    2014-07-01

    The domino retro [3+2] cycloaddition/cyclization reaction of bicyclic isoxazolidines 4 yielding [6.6.5]-tricyclic isoxazolidines 7 and [6.5.5]-tricyclic isoxazolidines 8, experimentally reported by Holmes et al., has been studied in toluene using DFT methods at the MPWB1K/6-311G** level. This domino reaction begins by a reto [3+2] cycloaddition reaction of the bicyclic isoxazolidines 4 forming the cyclic nitrones 5, which undergo a subsequent cyclization reaction yielding [6.6.5]-tricyclic isoxazolidines 7 or [6.5.5]-tricyclic isoxazolidines 8. The [3+2] cycloaddition reactions of cyclic nitrone 12 with ethylene 13, and with (Z)-but-2-enenitrile 15 were also studied in order to explain the role of the tether in the cyclization step. The present study shows that, unlike the [3+2] cycloaddition reaction of cyanoalkene 15, the cyano group in the cyclization step does not have any effect on the selectivity. The present study suggests that the presence of the BF3 catalyst in the domino reaction can change the formation of the [6.5.5]-tricyclic isoxazolidine 7 to the [6.6.5]-tricyclic isoxazolidine 8.

  14. Effect of externality in multiplex networks on one-layer synchronization

    Science.gov (United States)

    Jiang, Xin; Li, Meng; Zheng, Zhiming; Ma, Yifang; Ma, Lili

    2015-06-01

    Synchronization phenomenon plays an important role in the dynamic process on complex networks. In this letter, we consider synchronization under multiplex structures and explore the effect of external parts on the multilayered Kuramoto model with positive correlation between frequencies and degree. We show that large and strong mixing parts of the external layer may put off synchronization while the coupling strength of external layers has an accelerating, but limited, influence on synchronization. In particular, an explosive synchronization can be obtained by weakening the co-evolution coupling strength. The transition tends to be smooth when the co-evolution coupling strength increases. Our findings indicate that externality from multiplex networks, especially the mixing parts, and the co-evolution coupling strength should be of importance for synchronization on one certain layer.

  15. The use of external electronic tags on fish: an evaluation of tag retention and tagging effects

    DEFF Research Database (Denmark)

    Jepsen, Niels; Thorstad, Eva B.; Havn, Torgeir

    2015-01-01

    External tagging of fish with electronic tags has been used for decades for a wide range of marine and freshwater species. In the early years of fish telemetry research, it was the most commonly used attachment method, but later internal implants became preferred. Recently, the number of telemetry...... studies using external tagging has increased, especially with the development of archival tags (data storage tags, DSTs), pop-up satellite archival tags (PSATs) and other environment-sensing tags. Scientific evaluations of the tagging method are rather scarce for most species. We identified 89...... growth and survival have also been recorded, but direct mortality caused by external tagging seems rare. Most of the studies reviewed evaluate tag retention, survival, and tissue reactions. There is a general need for more research on the effects of external tagging of fish with electronic tags...

  16. An efficient synthesis of iminoquinones by a chemoselective domino ortho-hydroxylation/oxidation/imidation sequence of 2-aminoaryl ketones.

    Science.gov (United States)

    Chandrasekar, Selvaraj; Sekar, Govidasamy

    2016-03-21

    An efficient chemoselective domino oxidative homocoupling of 2-aminoaryl ketones in the presence of 2-iodoxybenzoic acid (IBX) for the synthesis of iminoquinone has been developed. The domino reaction proceeds via three consecutive steps, such as domino ortho-hydroxylation of 2-aminoaryl ketones, oxidation of a phenol derivative to benzoquinone and dimerization through imine formation to yield iminoquinone. Importantly, this reaction allows the recycling of the oxidant IBX by recovering the by-product iodosobenzoic acid (IBA) and oxidizing it back to IBX. A four step domino strategy for the synthesis of iminoquinone through in situ generation of 2-amino benzophenone from (2-amino phenyl)(phenyl)methanol was also developed.

  17. Domino-Like Intercellular Delivery of Undecylenic Acid-Conjugated Porous Silicon Nanoparticles for Deep Tumor Penetration.

    Science.gov (United States)

    Yong, Tuying; Hu, Jun; Zhang, Xiaoqiong; Li, Fuying; Yang, Hao; Gan, Lu; Yang, Xiangliang

    2016-10-05

    Improving the intratumoral distribution of anticancer agents remains the critical challenge for developing efficient cancer chemotherapy. Luminescent porous silicon nanoparticles (PSiNPs) have attracted considerable attention in the biomedical field especially in drug delivery. Here, we described the lysosomal exocytosis-mediated domino-like intercellular delivery of undecylenic acid-conjugated PSiNPs (UA-PSiNPs) for deep tumor penetration. UA-PSiNPs with significantly improved stability in physiological conditions were internalized into tumor cells by macropinocytosis-, caveolae-, and clathrin-mediated endocytosis and mainly colocalized with Golgi apparatus and lysosomes. Substantial evidence showed that UA-PSiNPs was excreted from cells via lysosomal exocytosis after cellular uptake. The exocytosed UA-PSiNPs induced a domino-like infection of adjacent cancer cells and allowed encapsulated doxorubicin (DOX) to deeply penetrate into both three-dimensional tumor spheroids and in vivo tumors. In addition, DOX-loaded UA-PSiNPs exhibited strong antitumor activity and few side effects in vivo. This study demonstrated that UA-PSiNPs as a drug carrier might be applied for deep tumor penetration, offering a new insight into the design of more efficient delivery systems of anticancer drugs.

  18. Effect of digital cellular phones on tachyarrhythmia analysis of automated external defibrillators.

    Science.gov (United States)

    Kanz, Karl-Georg; Kay, Mike V; Biberthaler, Peter; Russ, Walter; Lackner, Christian K; Mutschler, Wolf

    2004-04-01

    Emergency services personnel, family members, laypersons or patients often carry and use mobile phones on sites of emergencies. As there are reported effects on implanted pacemakers and cardioverter defibrillators, the influence of digital cellular phones on automated external defibrillators was studied. Twelve automated external defibrillator models were bench tested for their correct decision to or not to advise a shock, while being exposed to electromagnetic interference from a handheld cellular phone with 2 W or a portable cellular phone with 8 W transmitting power. The phones were programmed by a special subscriber identity module card to maximum output power with a carrier frequency of 906.2 MHz. The tests were conducted with a burst frequency of 217 Hz in speech mode and 2-8 Hz in discontinuous transmitting exchange mode. The sensitivity and specificity of electrocardiogram analysis systems were tested, with shockable and non-shockable rhythms provided by an electrocardiogram simulator and on two human subjects with normal sinus rhythm. A total of 8640 tests were recorded, each automated external defibrillator was tested a total of 720 times. The automated external defibrillators demonstrated a sensitivity of 100% and a specificity of 100%, representing a positive likelihood ratio of 8641 and a negative likelihood ratio of 0.000. In this setting all automated external defibrillators analysed correctly even under worst-case testing conditions, and performed excellently without any single failure. In some devices, voice prompts were distorted beyond comprehension, as the coil of the automated external defibrillator speaker received the pulsed signals. Shock advisory systems of automated external defibrillators are not susceptible to electromagnetic interference of 900 MHz cellular phones. Voice prompts, however, could be distorted by the operation of nearby digital mobile phones. During automated external defibrillator training this issue needs to be addressed.

  19. Effectiveness of individually delivered indicated school-based interventions on externalizing behavior

    NARCIS (Netherlands)

    Stoltz, S.E.M.J.; Londen, M. van; Dekovic, Maja; Orobio de Castro, B.; Prinzie, P.

    2012-01-01

    In the present study the results of two meta-analyses on the effectiveness of individually delivered indicated school-based interventions for externalizing behavior problems at elementary schools are presented. A distinction was made between studies that evaluated effects of interventions with only

  20. Effectiveness of Individually Delivered Indicated School-Based Interventions on Externalizing Behavior

    Science.gov (United States)

    Stoltz, Sabine; van Londen, Monique; Dekovic, Maja; de Castro, Bram Orobio; Prinzie, Peter

    2012-01-01

    In the present study the results of two meta-analyses on the effectiveness of "individually" delivered indicated school-based interventions for externalizing behavior problems at elementary schools are presented. A distinction was made between studies that evaluated effects of interventions with only an individual component (k = 11 studies, n =…

  1. Testing causal effects of maternal smoking during pregnancy on offspring's externalizing and internalizing behavior

    NARCIS (Netherlands)

    Dolan, C.V.; Geels, L.M.; Vink, J.M.; Beijsterveldt, C.E.M. van; Neale, M.C.; Bartels, M.; Boomsma, D.I.

    2016-01-01

    Maternal smoking during pregnancy (SDP) is associated with increased risk of externalizing and internalizing behaviors in offspring. Two explanations (not mutually exclusive) for this association are direct causal effects of maternal SDP and the effects of genetic and environmental factors common to

  2. A computational vector-map model of neonate saccades: modulating the externality effect through refraction periods.

    Science.gov (United States)

    Jansen, Peter A; Fiacconi, Chris M; Gibson, Laura C

    2010-11-23

    The present study develops an explicit and predictive computational model of neonate saccades based on the interaction of several simple mechanisms, including the tendency to fixate towards areas of high contrast, and the decay and recovery of a world-centered contrast representation simulating a low-level inhibition of return mechanism. Emergent properties similar to early visual behaviors develop, including the externality effect (or tendency to focus on external then internal features). The age-associated progression of this effect is modulated by the decay period of the model's contrast representation, where the high-level behavior of either scanning broadly or locally is modulated by a single decay parameter.

  3. EFFECTS OF COOLED EXTERNAL EXHAUST GAS RECIRCULATION ON DIESEL HOMOGENEOUS CHARGE COMPRESSION IGNITION ENGINE

    Institute of Scientific and Technical Information of China (English)

    SHI Lei; CUI Yi; DENG Kangyao

    2007-01-01

    The effects of cooled external exhaust gas recirculation (EGR) on the combustion and emission performance of diesel fuel homogeneous charge compression ignition (HCCI) are studied. Homogeneous mixture is formed by injecting fuel in-cylinder in the negative valve overlap (NVO) period. So, the HCCI combustion which has low NOx and smoke emission is achieved. Cooled external EGR can delay the start of combustion effectively, which is very useful for high cetane fuel (diesel) HCCI, because these fuels can easily self-ignition, which makes the start of combustion more early. External EGR can avoid the knock combustion of HCCI at high load which means that the EGR can expand the high load limit. HCCI maintains low smoke emission at various EGR rate and various load compared with conventional diesel engine because there is no fuel-rich area in cylinder.

  4. Examining Effectiveness of Group Cognitive-Behavioral Therapy for Externalizing and Internalizing Disorders in Urban Schools.

    Science.gov (United States)

    Eiraldi, Ricardo; Power, Thomas J; Schwartz, Billie S; Keiffer, Jackie N; McCurdy, Barry L; Mathen, Manju; Jawad, Abbas F

    2016-07-01

    This article presents outcome data of the implementation of three group cognitive-behavioral therapy (GCBT) interventions for children with externalizing behavior problems, anxiety, and depression. School counselors and graduate students co-led the groups in two low-income urban schools. Data were analyzed to assess pre-treatment to post-treatment changes in diagnostic severity level. Results of the exploratory study indicated that all three GCBT protocols were effective at reducing diagnostic severity level for children who had a primary diagnosis of an externalizing disorder, anxiety disorder, or depressive disorder at the clinical or intermediate (at-risk) level. All three GCBT protocols were implemented with relatively high levels of fidelity. Data on the effectiveness of the interventions for reducing diagnostic severity level for externalizing and internalizing spectrum disorders and for specific disorders are presented. A discussion of implementation of mental health evidence-based interventions in urban schools is provided. © The Author(s) 2016.

  5. Effects of Interaural Level and Time Differences on the Externalization of Sound

    DEFF Research Database (Denmark)

    Dau, Torsten; Catic, Jasmina; Santurette, Sébastien;

    - such as wide dynamic range compression - affects the ILDs and thereby potentially reduces the perceived degree of externalization. In the present study, the effect of room reverberation on the spectro-temporal behavior of ILDs was investigated. This was done by analyzing speech played at different distances...... and recorded on a head-andtorso simulator in a standard IEC 268-13 listening room. Next, the effect of ILD fluctuations on the degree of externalization was investigated in a listening experiment with normal-hearing listeners. The experiment was performed in the same standard listening room and a distant...... speech source was simulated via headphones using individual binaural impulse responses. The speech signal was then processed such that the naturally occurring ILD fluctuations were compressed. This manipulation reduced the perceived degree of externalization in the listening experiment, which...

  6. 基于Lotus Domino/Notes的电话站管理信息系统的设计与实现

    Institute of Scientific and Technical Information of China (English)

    颜湘军

    2003-01-01

    本文介绍了Lotus Domino/Notes的特点,探讨了利用Lotus Domino/Notes基于网络的实际应用方法,即在Lotus Domino/Notes平台上建立电话站管理信息系统的设计和实现方法.

  7. "Math Starring the Dominoes": Activities Using Dominoes Designed to Reinforce Basic Facts and to Stimulate Strategic Thinking for Problem Solving. (Grades 1-4.) Title I Elementary Mathematics Program.

    Science.gov (United States)

    Gronert, Joie; Marshall, Sally

    Activities and games which use dominoes to reinforce basic arithmetic skills are presented. Instructions and materials are provided for the activities and games, most of which involve addition and subtraction. Other skill areas which are covered include recognition and matching of domino patterns, multiplication, and division. A seven-item list of…

  8. "Math Starring the Dominoes": Activities Using Dominoes Designed to Reinforce Basic Facts and to Stimulate Strategic Thinking for Problem Solving. (Grades 1-4.) Title I Elementary Mathematics Program.

    Science.gov (United States)

    Gronert, Joie; Marshall, Sally

    Activities and games which use dominoes to reinforce basic arithmetic skills are presented. Instructions and materials are provided for the activities and games, most of which involve addition and subtraction. Other skill areas which are covered include recognition and matching of domino patterns, multiplication, and division. A seven-item list of…

  9. Effects of external focus of attention on balance: a short review.

    Science.gov (United States)

    Park, Sun Hee; Yi, Chae Woo; Shin, Ju Yong; Ryu, Young Uk

    2015-12-01

    [Purpose] The present study reviewed studies that examined the effects of attentional focus on balance. [Methods] Keywords such as "attentional", "focus", and "balance" were used to find relevant research papers in PubMed (www.ncbi.nlm.nih.gov/pubmed). Forty-five papers were found, and 18 of them were used for this study, excluding review papers and papers irrelevant to the topic of this study. [Results] Among the papers used for the review, the number of papers in which external focus produced effective outcomes was 15 (83.3%). The number of papers in which both external and internal focus produced effective outcomes was 2 (11.1%). The number of paper in which no instruction about attentional focus was effective was 1 (5.5%), and the number of papers in which internal focus was effective was zero. [Conclusion] This short review suggests clinical implications about how physical therapists can use attentional focus for balance rehabilitation of patients. Instructions about external focus of attention can generally be useful as a method to improve posture and balance control. Furthermore, the present reviews indicates that external focus of attention would be more useful in a rehabilitation stage in which the difficulty level of balance performance is gradually increased.

  10. The effect of external pressure on the magnetocaloric effect of Ni-Mn-In alloy.

    Science.gov (United States)

    Sharma, V K; Chattopadhyay, M K; Roy, S B

    2011-09-14

    The martensitic transition in Ni(50)Mn(34)In(16) alloy has been studied by measuring the magnetization of the alloy as a function of temperature, magnetic field and pressure. Magnetic field and pressure have opposite effects on the martensitic transition in this alloy; the martensitic transition temperature decreases with increasing magnetic field but it increases with increasing pressure. The effect of pressure on the magnetocaloric properties of this large magnetocaloric effect alloy has been investigated in detail. The magnitude of the peak in the isothermal magnetic entropy change in Ni(50)Mn(34)In(16) increases with pressure. The temperature at which the magnetocaloric effect reaches the peak value in this alloy increases from near 240 K under ambient pressure to near 280 K under an external pressure of 9.5 kbar. The temperature corresponding to the peak in the isothermal magnetic entropy change increases with increasing pressure at a rate which matches the rate of increase of the martensite start temperature with increasing pressure. The temperature dependence of the isothermal magnetic entropy change under different pressures is found to follow a universal curve for a particular magnetic field change. These results show that pressure as a control parameter can be used to tune the temperature regime of the magnetocaloric effect in the alloy. The effect of pressure on the martensitic transition also gives a clue as regards the possibility of tuning this temperature regime with elemental substitution.

  11. On the effect of external perturbation on amino acid salt bridge: a DFT study

    Indian Academy of Sciences (India)

    BISWA JYOTI DUTTA; NABAJIT SARMAH; PRADIP KR BHATTACHARYYA

    2017-05-01

    Effect of external perturbation (in terms of external electric field and solvents) on the stability of lysine-aspartic acid salt bridge was analyzed by density functional theory. Because of solvation, interaction energy in the aqueous phase is much lower as compared to gas phase. Interaction energy as well as stability (measured in terms of global hardness, HOMO energy and total electronic energy) are observed to be sensitive towards the strength and direction of the applied electric field. Gap between HOMO energy of the acids and salt bridge also points towards the feasibility of hydrogen bonding.

  12. Tunneling effect of the spin-2 Bose condensate driven by external magnetic fields

    OpenAIRE

    Yu, Zhao-xian; Jiao, Zhi-yong

    2003-01-01

    In this paper, we have studied tunneling effect of the spin-2 Bose condensate driven by external magnetic field. We find that the population transfers among spin-0 and spin-$\\pm1$, spin-0 and spin-$\\pm2$ exhibit the step structure under the external cosinusoidal magnetic field respectively, but there do not exist step structure among spin-$\\pm1$ and spin-$\\pm2$. The tunneling current among spin-$\\pm1$ and spin-$\\pm2$ may exhibit periodically oscillation behavior, but among spin-0 and spin-$\\p...

  13. Effect of external electric field on Cyclodextrin-Alcohol adducts: A DFT study

    Indian Academy of Sciences (India)

    Kundan Baruah; Pradip Kr Bhattacharyya

    2015-06-01

    Effect of external electric fields on the interaction energy between cyclodextrin and alcohol was analyzed in the light of density functional theory (DFT) and density functional reactivity theory (DFRT). Stability of the cyclodextrin-alcohol adducts was measured in terms of DFT based reactivity descriptor, global hardness, electrophilicity, and energy of the HOMO. Stability of adducts was observed to be sensitive towards the strength as well as direction of the applied external electric field. In addition, reactivity pattern follows the maximum hardness and minimum electrophilicity principles.

  14. Effect of external noise on the dynamical localization of two coupling electrons in quantum dot array

    Institute of Scientific and Technical Information of China (English)

    He An-Min; Duan Su-Qing; Zhao Xian-Geng

    2005-01-01

    The effect of external noise, which is characterized by an Ornstein-Uhlenbeck process, on the dynamical localization of two coupling electrons in a quantum dot array under the action of an ac electric field is studied. A numerical solution of the stochastic equations is obtained by averaging over stochastic trajectories. The results show that the external noise may destroy the dynamical localization, but the anti-noise capacity of the system is stronger when the two electrons are localized at the ends of the quantum dot array.

  15. External iliac artery injury secondary to indirect pressure wave effect from gunshot wound

    OpenAIRE

    Ng, Eugene; Choong, Andrew MTL

    2016-01-01

    In patients presenting with gunshot wounds, a high clinical suspicion of injury to vasculature and viscera remote from the projectile track is paramount. We present a case of a 17 year old male who sustained a gunshot wound to his abdomen and subsequently developed a right external iliac artery contusion requiring surgery as an indirect effect of the pressure wave from the bullet.

  16. Effect of an internally versus externally focused acl injury prevention program on injury risk

    NARCIS (Netherlands)

    Dallinga, J.; Benjaminse, A.; Gokeler, A.; Otten, Egbert; Lemmink, K.

    2014-01-01

    BACKGROUND: Anterior cruciate ligament (ACL) injury prevention programs have shown mixed results, which may be in part due to suboptimal training components. OBJECTIVE: Determine effects of a prevention program with external and internal focus of attention on (potential) biomechanical risk factors f

  17. Interaction Effects between Maternal Lifetime Depressive/Anxiety Disorders and Correlates of Children's Externalizing Symptoms

    Science.gov (United States)

    Piche, Genevieve; Bergeron, Lise; Cyr, Mireille; Berthiaume, Claude

    2011-01-01

    We investigated the interaction effects between mother's lifetime depressive/anxiety disorders and psychosocial correlates of 6 to 11 year-old children's self-reported externalizing symptoms in the Quebec Child Mental Health Survey. A representative subsample of 1,490 Quebec children aged 6 to 11 years was selected from the original sample. We…

  18. Effect of an internally versus externally focused acl injury prevention program on injury risk

    NARCIS (Netherlands)

    Dallinga, J.; Benjaminse, A.; Gokeler, A.; Otten, Egbert; Lemmink, K.

    2014-01-01

    BACKGROUND: Anterior cruciate ligament (ACL) injury prevention programs have shown mixed results, which may be in part due to suboptimal training components. OBJECTIVE: Determine effects of a prevention program with external and internal focus of attention on (potential) biomechanical risk factors

  19. The Interactive Effects of Temperament and Maternal Parenting on Toddlers' Externalizing Behaviours

    Science.gov (United States)

    van Aken, C.; Junger, M.; Verhoeven, M.; van Aken, M. A. G.; Dekovic, M.

    2007-01-01

    The present study aimed to determine the potential moderating effects of temperamental traits on the relation between parenting and toddlers' externalizing behaviours. For that purpose, this study examined the interplay between temperament and maternal parenting behaviours in predicting the level as well as the development of toddlers'…

  20. The Protective Effects of Adaptability, Study Skills, and Social Skills on Externalizing Student-Teacher Relationships

    Science.gov (United States)

    Fisher, Sycarah D.; Reynolds, Jennifer L.; Sheehan, Chelsea E.

    2016-01-01

    Although students with externalizing behaviors inherently exhibit behaviors that contribute to poor teacher relationships, little research has examined the positive characteristics these students may possess that serve to facilitate positive teacher relationships. This study explores the moderating effects of adaptability, social skills, and study…

  1. Effects of Internal and External Focus of Attention during Novices' Instructional Preparation on Subsequent Rehearsal Behaviors

    Science.gov (United States)

    Montemayor, Mark; Silvey, Brian A.; Adams, Amy L.; Witt, Kay L.

    2016-01-01

    The purpose of this study was to investigate the effects of internal versus external focus of attention during novice teachers' instructional preparation on their subsequent rehearsal behaviors. Thirty-two undergraduate instrumental music education students led bands in a series of three, 6-minute rehearsals on their assigned excerpt. Prior to…

  2. Effects of Internal and External Focus of Attention on Novices' Rehearsal Evaluations

    Science.gov (United States)

    Silvey, Brian A.; Montemayor, Mark

    2014-01-01

    The purpose of this study was to investigate the effects of internal and external focus of attention on novices' rehearsal evaluations. Thirty-two undergraduate instrumental music education students led bands in a series of three 6-minute rehearsals on their assigned excerpt. Prior to these rehearsals, participants were led in score study and…

  3. Renewable energy and negative externalities: the effect of wind turbines on house prices

    NARCIS (Netherlands)

    Dröes, M.I.; Koster, H.R.A.

    2014-01-01

    In many countries, wind turbines are constructed as part of a strategy to reduce dependence on fossil fuels. In this paper, we measure the external effect of wind turbines on the transaction prices of nearby houses. A unique house price dataset covering the period 1985-2011 is used, including the ex

  4. The Effects of Demographic, Internal and External University Environment Factors on Faculty Job Satisfaction in Vietnam

    Science.gov (United States)

    Duong, Minh-Quang

    2016-01-01

    University faculty members with higher job satisfaction are more productive, creative and positive attitude towards their job. Even less is known about university faculty job satisfaction in developing countries like Vietnam. This study examines the effects of demographic, internal and external university environment factors on faculty job…

  5. Effect of external and internal phosphate status on arsenic toxicity and accumulation in rice seedlings

    Institute of Scientific and Technical Information of China (English)

    WANG Lihong; DUAN Guilan

    2009-01-01

    Phosphorus (P) deficiency is thought to exacerbate the arsenic (As) phytotoxicity in paddy rice. Therefore, experiments were conducted to investigate the effects of external phosphate supply on As accumulation in and toxicity to rice plants under phosphate deficiency conditions. Rice seedlings being pretreated with -P (phosphorus deficiency) nutrient solution for 14 d accumulated more As than those pretreated with +P (normal phosphorus supply) nutrient solution. -P pretreated rice showed As toxicity symptoms after being exposed to 50 μmol/L arsenate for 4 h, while +P rice did not show any toxicity symptoms. Arsenic toxicity symptoms can be alleviated with increasing of external P concentrations. Arsenate uptake rate and accumulation corresponded with As toxicity in rice plants. Arsenic concentrations in rice roots decreased with increasing external phosphate concentrations. The lowest As accumulation and the highest P accumulation were found when the external P concentration reached 100 μmol/L. In a summary, P deficiency increased the sensitivity of rice to arsenate and increasing of external phosphate supply could alleviate As toxicity.

  6. Altruistic donor triggered domino-paired kidney donation for unsuccessful couples from the kidney-exchange program.

    Science.gov (United States)

    Roodnat, J I; Zuidema, W; van de Wetering, J; de Klerk, M; Erdman, R A M; Massey, E K; Hilhorst, M T; Ijzermans, J N M; Weimar, W

    2010-04-01

    Between January 2000 and July 2009, 132 individuals inquired about altruistic kidney donation to strangers. These donors were willing to donate to genetically and emotionally unrelated patients. Some altruistic donors wished to donate to a specific person, but most wished to donate anonymously. In domino-paired donation, the altruistic donor donates to the recipient of an incompatible couple; the donor of that couple (domino-donor) donates to another couple or to the waiting list. In contrast to kidney-exchange donation where bilateral matching of couples is required, recipient and donor matching are unlinked in domino-paired donation. This facilitates matching for unsuccessful couples from the kidney-exchange program where blood type O prevails in recipients and is under-represented in donors. Fifty-one altruistic donors (39%) donated their kidney and 35 domino-donors were involved. There were 29 domino procedures, 24 with 1 altruistic donor and 1 domino-donor, 5 with more domino-donors. Eighty-six transplantations were performed. Donor and recipient blood type distribution in the couples limited allocation to blood type non-O waiting list patients. The success rate of domino-paired donation is dependent on the composition of the pool of incompatible pairs, but it offers opportunities for difficult to match pairs that were unsuccessful in the kidney-exchange program.

  7. The first case of domino-split-liver transplantation in maple syrup urine disease.

    Science.gov (United States)

    Herden, Uta; Li, Jun; Fischer, Lutz; Brinkert, Florian; Blohm, Martin; Santer, René; Nashan, Bjoern; Grabhorn, Enke

    2017-09-01

    The enzymatic defect in MSUD results in accumulation of neurotoxic metabolites of BCAAs. LTX has shown to be a feasible strategy in patients non-responsive to diet. Because of sufficient enzyme activity in extrahepatic tissues in healthy people, the MSUD liver graft is a suitable domino organ. We present the first case of a technical challenging ex situ split of a MSUD domino organ transplanted into two pediatric recipients. The domino graft donor was a 21-year-old female (58 kg) suffering from MSUD with recurrent metabolic decompensation despite strict diet. The organ was allocated to a 14-year-old girl (55 kg) with primary sclerosing cholangitis. Due to excellent organ quality and suitable anatomy, a backward split for a girl of 3 months (5 kg) with decompensated liver cirrhosis due to biliary atresia was performed. The postoperative course was without relevant complications, and the three recipients were discharged on postoperative days 28, 29, and 45, respectively, with good organ function. BCAAs in plasma were normal in the two domino graft recipients, and the MSUD patient showed mildly elevated but stable BCAA concentrations despite an unrestricted diet. Split-domino LTX enabled successful transplantation of three patients of the waiting list with only one deceased donor graft. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. The current density in quantum electrodynamics in time-dependent external potentials and the Schwinger effect

    CERN Document Server

    Zahn, Jochen

    2015-01-01

    In the framework of quantum electrodynamics (QED) in external potentials, we introduce a method to compute the time-dependence of the expectation value of the current density for time-dependent homogeneous external electric fields. We apply it to the so-called Sauter pulse. For late times, our results agree with the asymptotic value due to electron-positron pair production. For sub-critical peak field strengths, or results agree very well with the general expression derived by Serber for the linearization in the external field. In particular, the expectation value of the current density at intermediate times can be much greater than at asymptotic times. We comment on consequences of these findings for recent proposals to test the Schwinger effect with high intensity lasers using processes at intermediate times.

  9. Effects of external magnetic field on biodistribution of nanoparticles: A histological study

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Tony [Department of Neurology, Chang Gung University College of Medicine and Memorial Hospital, 199 Tung-Hwa N Rd, Taipei, Taiwan (China); Hua, M.-Y. [Department of Chemical and Material Engineering, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan (China); Chen Jyhping [Department of Chemical and Material Engineering, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan (China); Wei, K.-C. [Department of Neurosurgery, Chang Gung University College of Medicine and Memorial Hospital, 199 Tung-Hwa N Rd, Taipei, Taiwan (China); Jung, S.-M. [Department of Pathology, Chang Gung University College of Medicine and Memorial Hospital, 199 Tung-Hwa N Rd, Taipei, Taiwan (China); Chang, Y.-J. [Department of Neurology, Chang Gung University College of Medicine and Memorial Hospital, 199 Tung-Hwa N Rd, Taipei, Taiwan (China); Jou, M.-J. [Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan (China); Ma, Y.-H. [Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan (China)]. E-mail: yhma@mail.cgu.edu.tw

    2007-04-15

    This study investigates the effect of external magnetic fields on the biodistribution of nanoparticles (NP). A NdFeB magnet of 2.4 kG was externally applied over the left femoral artery or right kidney. The 250 nm dextran-coated Fe{sub 3}O{sub 4} NP was injected via tail vein in healthy rats, and organs were taken 1 or 24 h later. Prussian blue stain revealed that NP were more rapidly retained in the liver and spleen than in the lungs. NP aggregation observed in the kidney and femoral artery after application of external magnets was time dependent. Hollow organs such as the intestine, colon, and urinary bladder retained little NP.

  10. Effect of external fields on the energies of hydrogenic donor with the anharmonic confinement potential

    Energy Technology Data Exchange (ETDEWEB)

    Aciksoz, E.; Bayrak, O. [Department of Physics, Akdeniz University, 07058 Antalya (Turkey); Soylu, A., E-mail: asimsoylu@gmail.com [Department of Physics, Nigde University, 51240 Nigde (Turkey)

    2015-01-01

    The impurity binding energy in the GaAs−Ga{sub 1−x}Al{sub x}As system is studied with an anharmonic type confinement potential by taking into account the influence of the external electric and magnetic fields within the framework of the effective mass approximation and asymptotic iteration method (AIM). The influence of the external electromagnetic fields and anharmonicity on a donor binding energy is examined systematically. It is shown that the donor binding energy is highly dependent on the external electric and magnetic fields and the confinement potential shapes. Both the electric and magnetic fields are increased, the binding energies increase for each of them. However, the behaviors of increase in the weak and strong fields’ regimes have different character a bit. Furthermore, when the more anharmonicity is considered, the binding energy of donor slightly increases as well.

  11. Effect of external energy on atomic, crystalline and powder characteristics of antimony and bismuth powders

    Indian Academy of Sciences (India)

    Vikram V Dabhade; Rama Mohan R Tallapragada; Mahendra Kumar Trivedi

    2009-10-01

    Next to atoms and molecules the powders are the smallest state of matter available in high purities and large quantities. The effect of any external energy on the shape, morphology and structure can thus be studied with relative ease. The present investigation deals with the effect of a non-contact external energy on the powders of antimony and bismuth. The characteristics of powders treated by external energy are compared with the as received powders (control). The average particle sizes, 50 and 99, the sizes below which 99% of the particles are present showed significant increase and decrease indicating that the energy had caused deformation and fracture as if the powders have been subjected to high energy milling. To be able to understand the reasons for these changes the powders are characterized by techniques such as X-ray diffraction (XRD), surface area determination (BET), thermal analytical techniques such as DTA–DTG, DSC–TGA and SDTA and scanning electron microscopy (SEM). The treated powder samples exhibited remarkable changes in the powder characteristics at all structural levels starting from polycrystalline particles, through single crystal to atoms. The external energy had changed the lattice parameters of the unit cell which in turn changed the crystallite size and density. The lattice parameters are then used to compute the weight and effective nuclear charge of the atom which showed significant variation. It is speculated that the external energy is acting on the nucleus through some reversible weak interaction of larger cross section causing changes in the proton to neutron ratios. Thus the effect is felt by all the atoms, and hence the unit cell, single crystal grain and grain boundaries. The stresses generated in turn may have caused deformation or fracture of the weak interfaces such as the crystallite and grain boundaries.

  12. Domino boudinage under layer-parallel simple shear

    Science.gov (United States)

    Dabrowski, Marcin; Grasemann, Bernhard

    2014-11-01

    The boudin segments of a torn competent layer experience synthetic rotation in layer-parallel simple shear. As long as the individual segments in a boudin train are constrained by their neighbors, even a highly viscous boudin deforms internally to create the necessary space for rotation. The rotation rate is then much smaller compared to the case of an isolated segment. Hence, a small tilt of boudin segments is not indicative of low strain. The rotation rate at this stage largely depends on the aspect ratio of the boudin segments and the scaled gap width. Once the tilted boudins are no longer constrained by their neighbors, the rotation rate greatly accelerates. In the case of a low viscosity ratio between the boudins and the host, the boudin segments develop complex shapes, which may give an impression of shear-band boudins forming under the opposite shear sense. We furthermore investigate the behavior of boudin trains of finite length. The terminal segments are displaced out of the shear plane, deforming into isoclinal folds, and separate into groups of boudin segments that rotate into the shear direction and eventually lead to an overall chaotic appearance of the structure. Natural examples of domino boudinage from a high shear -strain detachment zone in the Western Cyclades (Greece) show many similarities with the modeled structures suggesting that, under simple shear deformation, the rotation and separation of boudin segments is an indicator for high shear strain.

  13. Domino et fraturi: An unpublished graffito from roman Sirmium

    Directory of Open Access Journals (Sweden)

    Nedeljković Vojin

    2012-01-01

    Full Text Available In the Regional Museum of Srem in Sremska Mitrovica, Serbia, a Roman brick is preserved, containing an inscription (Inv. A/5342. Originating from any of the numerous Roman structures in the capital city of Sirmium - most probably from Site 4 (Villa or Site 1a (Palace - the brick exhibits a graffito in Latin which reads as follows: Domino et fraturi Maxime salutem Valerus Januarius Written before the brick was baked, this greeting obviously went from somebody present at the brick plant to another person engaged locally in the business of construction. To address the recipient of a message as dominus frater is a well-attested style in Roman military circles, especially between equals, from the early 2nd century on. Phonologically, the spelling fraturi (for fratri is a remarkable instance of anaptyxis, vulgar, but only rarely occurring in the sources. The pendent vocative Maxime is probably due to the actual formula being a contamination of two known types, Maximo salutem and Maxime vale. Judging by their cognomenta, both men, Januarius and Maximus, may very well have been of indigenous origin, whereas the nomen Valerius may have been acquired through service in the imperial army or administration under the Tetrarchs.

  14. The effective potential of composite fields in weakly coupled QED in a uniform external magnetic field

    CERN Document Server

    Lee, D S; Ng, Y J; Shovkovy, I A

    1999-01-01

    The effective potential for the composite fields responsible for chiral symmetry breaking in weakly coupled QED in a magnetic field is derived. The global minimum of the effective potential is found to acquire a non-vanishing expectation value of the composite fields that leads to generating the dynamical fermion mass by an external magnetic field. The results are compared with those for the Nambu-Jona-Lasinio model.

  15. The effect of external factors on dielectric permittivity of Rochelle salt: humidity, annealing, stresses, electric field

    Directory of Open Access Journals (Sweden)

    A.G.Slivka

    2005-01-01

    Full Text Available The effect of external factors, such as dessicating/wetting, thermal annealing, uniaxial and hydrostatic pressure, on the dielectric permittivity of Rochelle salt crystals is investigated. The obtained results are compared with the available literature data and analyzed within the phenomenological Landau approach. A significant effect of the internal polar point defects in crystals and storage conditions on the dielectric permittivity is shown.

  16. The Effectiveness of Art Therapy in Reducing Internalizing and Externalizing Problems of Female Adolescents.

    Science.gov (United States)

    Bazargan, Yasaman; Pakdaman, Shahla

    2016-01-01

    The internalizing and externalizing problems relating to childhood and adolescent have always been significant. Because there is special considerations in establishing communication with them and hence, the therapeutic methods for these problems must take into account these considerations. As establishing a therapeutic relationship is an important component of effective counseling, it seems that art therapy may help alleviate these problems. The purpose of this study is to determine the effectiveness of art therapy in reducing internalizing and externalizing problems of adolescent girls (14 - 18 years old). This is a semi-experimental study carried out in the form of a pre-test/post-test design with control group. The population of this study includes female students of Gole Laleh School of Art in district 3 of Tehran, Iran, out of which 30 students with internalizing problems and 30 individuals with externalizing problems were selected through targeted sampling. Students were randomly assigned to control and experimental groups. Experimental groups participated in 6 painting sessions designed based on Art therapy theories and previous studies. The material used for diagnosis of the problems in posttest and pretest was an Achenbach self-assessment form. Data were analyzed using a mixed analysis of variance (ANOVA). Our results showed that Art therapy significantly reduced internalizing problems (F = 17.61, P Art therapy as a practical therapeutic method can be used to improve internalizing problems. To reduce externalizing problems, more sessions may be needed. Thus, future studies are required to insure these findings.

  17. Cognitive-behavioral therapy for externalizing disorders: A meta-analysis of treatment effectiveness.

    Science.gov (United States)

    Battagliese, Gemma; Caccetta, Maria; Luppino, Olga Ines; Baglioni, Chiara; Cardi, Valentina; Mancini, Francesco; Buonanno, Carlo

    2015-12-01

    Externalizing disorders are the most common and persistent forms of maladjustment in childhood. The aim of this study was to conduct a meta-analysis evaluating the effectiveness of Cognitive Behavioral Therapy (CBT) to reduce externalizing symptoms in two disorders: Attention Deficit Hyperactivity Disorder (ADHD) and Oppositive Defiant Disorder (ODD). The efficacy of CBT to improve social competence and positive parenting and reduce internalizing behaviors, parent stress and maternal depression was also explored. The database PsycInfo, PsycARTICLES, Medline and PubMed were searched to identify relevant studies. Twenty-one trials met the inclusion criteria. Results showed that the biggest improvement, after CBT, was in ODD symptoms (-0.879) followed by parental stress (-0.607), externalizing symptoms (-0.52), parenting skills (-0.381), social competence (-0.390) and ADHD symptoms (-0.343). CBT was also associated with improved attention (-0.378), aggressive behaviors (-0.284), internalizing symptoms (-0.272) and maternal depressive symptoms (-0.231). Overall, CBT is an effective treatment option for externalizing disorders and is also associated with reduced parental distress and maternal depressive symptoms. Multimodal treatments targeting both children and caregivers' symptoms (e.g. maternal depressive symptoms) appear important to produce sustained and generalized benefits.

  18. DOMINO: A fast 3D cartesian discrete ordinates solver for reference PWR simulations and SPN validation

    Energy Technology Data Exchange (ETDEWEB)

    Courau, T.; Moustafa, S.; Plagne, L.; Poncot, A. [EDF R and D, 1, Av du General de Gaulle, F92141 Clamart cedex (France)

    2013-07-01

    As part of its activity, EDF R and D is developing a new nuclear core simulation code named COCAGNE. This code relies on DIABOLO, a Simplified PN (SPN) method to compute the neutron flux inside the core for eigenvalue calculations. In order to assess the accuracy of SPN calculations, we have developed DOMINO, a new 3D Cartesian SN solver. The parallel implementation of DOMINO is very efficient and allows to complete an eigenvalue calculation involving around 300 x 10{sup 9} degrees of freedom within a few hours on a single shared-memory supercomputing node. This computation corresponds to a 26-group S{sub 8} 3D PWR core model used to assess the SPN accuracy. At the pin level, the maximal error for the SP{sub 5} DIABOLO fission production rate is lower than 0.2% compared to the S{sub 8} DOMINO reference for this 3D PWR core model. (authors)

  19. Gold-Catalyzed Domino Synthesis of Functionalized Benzofurans and Tetracyclic Isochromans via Formal Carboalkoxylation.

    Science.gov (United States)

    Obata, Tomoyuki; Suzuki, Sho; Nakagawa, Asuka; Kajihara, Ryota; Noguchi, Keiichi; Saito, Akio

    2016-08-19

    A domino synthesis of benzofurans with the modification of side chains from α-alkoxyalkyl o-alkynylaryl ethers (n = 0) and electron-rich arenes has been developed. In the present domino reaction, which would proceed via the α-alkoxyalkylation of arenes with an intermediate in the migratory cycloisomerization of o-alkynylaryl ethers followed by the nucleophilic addition of benzofurans to benzyl ethers, a cationic Au(III) catalyst activates the C-C π bond and the C-O σ bond. The present method could be extended to Au(I)-catalyzed domino synthesis of tetracyclic isochromans from α-alkoxyalkyl (o-alkynylaryl)methyl ethers (n = 1) and aryl methoxymethyl ethers.

  20. Effects of external rotation on anteroposterior translations in the shoulder: a pilot study.

    Science.gov (United States)

    Brown, Andrew J; Debski, Richard E; Voycheck, Carrie A; McMahon, Patrick J

    2014-08-01

    Using physical examination to make the diagnosis of shoulder instability can be difficult, because typical examination maneuvers are qualitative, difficult to standardize, and not reproducible. Measuring shoulder translation is especially difficult, which is a particular problem, because measuring it inaccurately may result in improper treatment of instability. The objective of this study was to use a magnetic motion tracking system to quantify the effects of external rotation of the abducted shoulder on a simulated simple translation test in healthy subjects. Specifically, we hypothesized that (1) increasing external rotation of the abducted shoulder would result in decreasing translation; (2) intraobserver repeatability would be less than 2 mm at all external rotation positions; and (3) mean side-to-side differences would be less than 2 mm at all external rotation positions. The intraobserver repeatability and side-to-side differences of AP translation were quantified with a noninvasive magnetic motion tracking system and automated data analysis routine in nine healthy subjects at four positions of external rotation with the arm abducted. A shoulder positioning apparatus was used to maintain the desired arm position. No differences in translations between the positions of external rotation were found (p = 0.48). Intraobserver repeatability was 1.1 mm (SD, 0.8 mm) and mean side-to-side differences were small: 2.7 mm (SD, 2.8 mm), 2.8 mm (SD, 1.8 mm), 2.5 mm (SD, 1.8 mm), and 4.0 mm (SD, 2.6 mm) at 0°, 20°, 40°, and 60° of external rotation, respectively. The intraobserver repeatability was strong and the side-to-side differences in translation were small with the magnetic motion tracking system, which is encouraging for development of an improved quantitative test to assess shoulder translation for fast and low-cost diagnosis of shoulder instability. Clinicians may not have to position the contralateral, normal, abducted shoulder in precisely the same position

  1. Effect of buffer layer and external stress on magnetic properties of flexible FeGa films

    Science.gov (United States)

    Zhang, Xiaoshan; Zhan, Qingfeng; Dai, Guohong; Liu, Yiwei; Zuo, Zhenghu; Yang, Huali; Chen, Bin; Li, Run-Wei

    2013-05-01

    We systematically investigated the effect of a Ta buffer layer and external stress on the magnetic properties of magnetostrictive Fe81Ga19 films deposited on flexible polyethylene terephthalate (PET) substrates. The Ta buffer layers could effectively smoothen the rough surface of PET. As a result, the FeGa films grown on Ta buffer layers exhibit a weaker uniaxial magnetic anisotropy and lower coercivity, as compared to those films directly grown on PET substrates. By inward and outward bending the FeGa/Ta/PET samples, external in-plane compressive and tensile stresses were applied to the magnetic films. Due to the inverse magnetostrictive effect of FeGa, both the coercivity and squareness of hysteresis loops for FeGa/Ta films could be well tuned under various strains.

  2. Effects of external potassium (k supply on drought tolerances of two contrasting winter wheat cultivars.

    Directory of Open Access Journals (Sweden)

    Jiguang Wei

    Full Text Available BACKGROUND: Drought is a common stress limiting crops growth and productivities worldwide. Water deficit may increase cellular membrane permeability, resulting in K outflow. Internal K starvation may disorder plant metabolism and limit plant growth. However, it is seldom reported about the effects of external K on drought tolerance of contrasting wheat cultivars. METHODOLOGY/PRINCIPAL FINDINGS: A hydroponics experiment was carried out in a non-controlled greenhouse. Seedlings of drought-tolerant SN16 and intolerant JM22 were simultaneously treated by five levels of K2CO3 (0, 2.5, 5, 7.5, 10 mM and two levels of PEG6000 (0, 20% for 7 days. External K2CO3 significantly increased shoot K(+ content, water potential, chlorophyll content as well as gas exchange, but decreased electrolyte leakage (EL and MDA content in both cultivars under PEG6000 stress. Antioxidant enzymes activities were up-regulated by PEG6000 while external K2CO3 reduced those changes. Molecular basis was explained by measuring the expression levels of antioxidant enzymes related genes. Shoot and root biomass were also increased by K2CO3 supply under drought stress. Although adequate K2CO3 application enhanced plant growth for both cultivars under drought stress, SN16 was better than JM22 due to its high drought tolerance. CONCLUSIONS/SIGNIFICANCE: Adequate external K may effectively protect winter wheat from drought injuries. We conclude that drought-tolerant wheat combined with adequate external K supply may be a promising strategy for better growth in arid and semi-arid regions.

  3. The Effect of Fatigued External Rotator Muscles of the Shoulder on the Shoulder Position Sense

    Directory of Open Access Journals (Sweden)

    Naoya Iida

    2011-10-01

    Full Text Available This study aimed to investigate the effect of fatigue in shoulder external rotator muscles on position sense of shoulder abduction, internal rotation, and external rotation. The study included 10 healthy subjects. Shoulder position sense was measured before and after a fatigue task involving shoulder external rotator muscles. The fatigue task was performed using an isokinetic machine. To confirm the muscle fatigue, electromyography (EMG was recorded, and an integrated EMG and median power frequency (MDF during 3 sec performed target torque were calculated. After the fatigue task, the MDF of the infraspinatus muscle significantly decreased. This indicates that the infraspinatus muscle was involved in the fatigue task. In addition, the shoulder position sense of internal and external rotation significantly decreased after the fatigue task. These results suggest that the fatigue reduced the accuracy of sensory input from muscle spindles. However, no significant difference was observed in shoulder position sense of abduction before and after the fatigue task. This may be due to the fact that infraspinatus muscle did not act as prime movers in shoulder abduction. These results suggest that muscle fatigue decreased position sense during movements in which the affected muscles acted as prime movers.

  4. Effect of Training and Level of External Auditory Feedback on the Singing Voice: Pitch Inaccuracy.

    Science.gov (United States)

    Bottalico, Pasquale; Graetzer, Simone; Hunter, Eric J

    2017-01-01

    One of the most important aspects of singing is the control of fundamental frequency. The effects on pitch inaccuracy, defined as the distance in cents in equally tempered tuning between the reference note and the sung note, of the following conditions were evaluated: (1) level of external feedback, (2) tempo (slow or fast), (3) articulation (legato or staccato), (4) tessitura (low, medium, or high), and (5) semi-phrase direction (ascending or descending). The subjects were 10 nonprofessional singers and 10 classically trained professional or semi-professional singers (10 men and 10 women). Subjects sang one octave and a fifth arpeggi with three different levels of external auditory feedback, two tempi, and two articulations (legato or staccato). It was observed that inaccuracy was greatest in the descending semi-phrase arpeggi produced at a fast tempo and with a staccato articulation, especially for nonprofessional singers. The magnitude of inaccuracy was also relatively large in the high tessitura relative to the low and the medium tessitura for such singers. Contrary to predictions, when external auditory feedback was strongly attenuated by the hearing protectors, nonprofessional singers showed greater pitch accuracy than in the other external feedback conditions. This finding indicates the importance of internal auditory feedback in pitch control. With an increase in training, the singer's pitch inaccuracy decreases. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  5. Classical spin glass system in external field with taking into account relaxation effects

    Science.gov (United States)

    Gevorkyan, A. S.; Abajyan, H. G.

    2013-08-01

    We study statistical properties of disordered spin systems under the influence of an external field with taking into account relaxation effects. For description of system the spatial 1D Heisenberg spin-glass Hamiltonian is used. In addition, we suppose that interactions occur between nearest-neighboring spins and they are random. Exact solutions which define angular configuration of the spin in nodes were obtained from the equations of stationary points of Hamiltonian and the corresponding conditions for the energy local minimum. On the basis of these recurrent solutions an effective parallel algorithm is developed for simulation of stabile spin-chains of an arbitrary length. It is shown that by way of an independent order of N 2 numerical simulations (where N is number of spin in each chain) it is possible to generate ensemble of spin-chains, which is completely ergodic which is equivalent to full self-averaging of spin-chains' vector polarization. Distributions of different parameters (energy, average polarization by coordinates, and spin-spin interaction constant) of unperturbed system are calculated. In particular, analytically is proved and numerically is shown, that for the Heisenberg nearest-neighboring Hamiltonian model, the distribution of spin-spin interaction constants as opposed to widely used Gauss-Edwards-Anderson distribution satisfies Levy alpha-stable distribution law. This distribution is nonanalytic function and does not have variance. In the work we have in detail studied critical properties of an ensemble depending on value of external field parameters (from amplitude and frequency) and have shown that even at weak external fields the spin-glass systemis strongly frustrated. It is shown that frustrations have fractal behavior, they are selfsimilar and do not disappear at scale decreasing of area. By the numerical computation is shown that the average polarization of spin-glass on a different coordinates can have values which can lead to

  6. Late effects of external radiotherapy on the thyroid gland; Effets tardifs de la radiotherapie externe sur la glande thyroide

    Energy Technology Data Exchange (ETDEWEB)

    Monnier, A. [Centre Hospitalier general A-Boulloche, 25 - Montbeliard (France)

    1997-12-01

    The thyroid is the purest endocrine gland in the body and is likely to produce clinically significant abnormalities after external radiotherapy. Functional clinical modifications after direct irradiation exceeding 30 Gy are essentially related to hypothyroidism which may be clinically overt or subclinical with normal serum free thyroxine levels and high thyrotropin concentrations; the risk of hyperthyroidism, silent thyroiditis and Hashimoto`s disease is also increased. secondary hypothyroidism related to irradiation of the hypothalamus and the pituitary gland may arise with doses over 40-50 Gy following treatment for brain and nasopharyngeal tumors - Morphological glandular modifications induced by radiotherapy are responsible for the appearance of benign adenomas, more rarely cystic degenerations and specially well differentiated papillary or follicular carcinomas among children and adults. After irradiation during childhood for benign or malignant tumors, thyroid cancers are more frequent, higher for younger children, and the relative excess risk is increased from 15.6-to 53-fold; tumors can belatedly occur, more than 35 years after initial therapy. Thereby, in order to limit excess morbidity, it is evident that long term supervision with careful clinical and biological evaluations is necessary for patients who previously received neck, upper mediastinum and pituitary radiation therapy. (author)

  7. Depressive symptoms and externalizing behaviors among Hispanic immigrant adolescents: Examining longitudinal effects of cultural stress.

    Science.gov (United States)

    Cano, Miguel Ángel; Schwartz, Seth J; Castillo, Linda G; Romero, Andrea J; Huang, Shi; Lorenzo-Blanco, Elma I; Unger, Jennifer B; Zamboanga, Byron L; Des Rosiers, Sabrina E; Baezconde-Garbanati, Lourdes; Lizzi, Karina M; Soto, Daniel W; Oshri, Assaf; Villamar, Juan Andres; Pattarroyo, Monica; Szapocznik, José

    2015-07-01

    This study examined longitudinal effects of cultural stress (a latent factor comprised of bicultural stress, ethnic discrimination, and negative context of reception) on depressive symptoms and a range of externalizing behaviors among recently (≤5 years in the U.S. at baseline) immigrated Hispanic adolescents. A sample of 302 adolescents (53% boys; mean age 14.51 years) completed baseline measures of perceived ethnic discrimination, bicultural stress, and perceived negative context of reception; and outcome measures of depressive symptoms, cigarette smoking, alcohol use, aggressive behavior, and rule-breaking behavior six months post-baseline. A path analysis indicated that higher cultural stress scores predicted higher levels of all outcomes. These effects were consistent across genders, but varied by study site. Specifically, higher cultural stress scores increased depressive symptoms among participants in Miami, but not in Los Angeles. Findings suggest that cultural stress is a clinically relevant predictor of depressive symptoms and externalizing behaviors among Hispanic immigrant adolescents.

  8. The effect of infected external computers on the spread of viruses: A compartment modeling study

    Science.gov (United States)

    Yang, Lu-Xing; Yang, Xiaofan

    2013-12-01

    Inevitably, there exist infected computers outside of the Internet. This paper aims to understand how infected external computers affect the spread of computer viruses. For that purpose, a new virus-antivirus spreading model, which takes into account the effect of infected/immune external computers, is established. A systematic study shows that, unlike most previous models, the proposed model admits no virus-free equilibrium and admits a globally asymptotically stable viral equilibrium. This result implies that it would be practically impossible to eradicate viruses on the Internet. As a result, inhibiting the virus prevalence to below an acceptable level would be the next best thing. A theoretical study reveals the effect of different parameters on the steady virus prevalence. On this basis, a number of suggestions are made so as to contain virus spreading.

  9. Therapeutic effect of external-route microsurgery for rhegmatogenous retinal detachment

    Directory of Open Access Journals (Sweden)

    Jian-Xun Zhu

    2014-07-01

    Full Text Available AIM: To study the therapeutic effect of external-route microsurgery forrhegmatogenous retinal detachment.METHODS: In 55 patients(55 eyeswith rhegmatogenous retinal detachment, drainage of subretinal fluid, examination of locating the holes, sclera cryotherapy, scleral buckling, and vitreous cavity injection of filtrated air were performed under surgical microscope.RESULTS: The retinal reattachment occurred in 50 cases after the primary surgery. The final rate of reattachment was 91% during 6-12mo follow-up. The retinal reattachment occurred in 1 case(recurrent retinal detachmentafter the secondary surgery and in 4 cases(recurrent retinal detachmentafter vitrectomy. The eyesight was improved with different degrees in 55 cases.CONCLUSION: The external-route microsurgery for rhegmatogenous retinal detachment is simple, safe and effective.

  10. The Effects of Internal and External Irreversibility of a Vapor Compression Refrigeration Cycle

    Science.gov (United States)

    Wang, Fu-Jen; Chiou, Jeng-Shing

    The concept of finite-time thermodynamics is employed to investigate the optimal refrigeration rate for an irreversible refrigeration cycle. The heat transfer between the system (internal) fluid and cooling (external) fluid takes place at the actual heat exchanger, which has the finite-size heat transfer area and the realistic heat transfer effectiveness. The internal irreversibility results from the compression process and the expansion process are also considered. The optimal refrigeration rate is calculated and expressed in terms of the irreversibility parameter (Ir), coefficient of performance (COP), the time ratio(γ) of heat transfer processes and the effectiveness of heat exchanger. The derived COP which consider both the external and internal irreversibility can thus be considered as the benchmark value for a practical refrigeration cycle, and the parametric study can provide the basis for both determination of optimal operating conditions and design of a practical refrigeration cycle.

  11. External iliac artery injury secondary to indirect pressure wave effect from gunshot wound

    Institute of Scientific and Technical Information of China (English)

    Eugene Ng; Andrew MTL.Choong

    2016-01-01

    In patients presenting with gunshot wounds,a high clinical suspicion of injury to vasculature and viscera remote from the projectile track is paramount.We present a case of a 17 year old male who sustained a gunshot wound to his abdomen and subsequently developed a right external iliac artery contusion requiring surgery as an indirect effect of the pressure wave from the bullet.

  12. Effect of an External Oriented Magnetic Field on Entropy Generation in Natural Convection

    OpenAIRE

    Atef El Jery; Nejib Hidouri; Mourad Magherbi; Ammar Ben Brahim

    2010-01-01

    The influence of an external oriented magnetic field on entropy generation in natural convection for air and liquid gallium is numerically studied in steady-unsteady states by solving the mass, the momentum and the energy conservation equations. Entropy generation depends on five parameters which are: the Prandtl number, the irreversibility coefficients, the inclination angle of the magnetic field, the thermal Grashof and the Hartmann numbers. Effects of these parameters on total and local ir...

  13. Internalizing and externalizing personality and subjective effects in a sample of adolescent cannabis users.

    Science.gov (United States)

    García-Sánchez, Sara; Matalí, Josep Lluís; Martín-Fernández, María; Pardo, Marta; Lleras, Maria; Castellano-Tejedor, Carmina; Haro, Josep Maria

    2016-10-06

    Cannabis is the illicit substance most widely used by adolescents. Certain personality traits such as impulsivity and sensation seeking, and the subjective effects experienced after substance use (e.g. euphoria or relaxation) have been identified as some of the main etiological factors of consumption. This study aims to categorize a sample of adolescent cannabis users based on their most dominant personality traits (internalizing and externalizing profile). Then, to make a comparison of both profiles considering a set of variables related to consumption, clinical severity and subjective effects experienced. From a cross-sectional design, 173 adolescents (104 men and 69 women) aged 13 to 18 asking for treatment for cannabis use disorder in an Addictive Behavior Unit (UCAD) from the hospital were recruited. For the assessment, an ad hoc protocol was employed to register consumption, the Millon Adolescent Clinical Inventory (MACI) and the Addiction Research Center Inventory (ARCI) 49-item short form were also administered. Factor analysis suggested a two-profile solution: Introverted, Inhibited, Doleful, Dramatizing (-), Egotistic (-), Self-demeaning and Borderline tendency scales composed the internalizing profile, and Submissive (-), Unruly, Forceful, Conforming (-) and Oppositional scales composed the externalizing profile. The comparative analysis showed that the internalizing profile has higher levels of clinical severity and more subjective effects reported than the externalizing profile. These results suggest the need to design specific intervention strategies for each profile.

  14. Integrated System on Domino 6 Platform Using Web Service%应用Web Service技术实现Domino 6平台系统整合

    Institute of Scientific and Technical Information of China (English)

    康永; 唐巍

    2008-01-01

    在分析了目前Domino的优势和所面临的整合问题的基础上,提出应用WebService技术实现Domino 6平台系统整合,同时在Domino平台上给出了实现WebService技术的几种方式,并针对几种方式进行了性能上的比较.

  15. Domino/Notes开发基于Web的办公自动化系统%Using Domino/Notes to develop office-automation system based on web

    Institute of Scientific and Technical Information of China (English)

    谢丽红; 战亚杰

    2004-01-01

    结合包钢炼钢厂办公自动化系统介绍了在Domino/NotesR5平台上开发基于Web的办公自动化系统的一点心得体会,以及对Domino系统管理和数据库维护方面的几点建议.

  16. Opposing effects of external gibberellin and Daminozide on Stevia growth and metabolites.

    Science.gov (United States)

    Karimi, Mojtaba; Hashemi, Javad; Ahmadi, Ali; Abbasi, Alireza; Pompeiano, Antonio; Tavarini, Silvia; Guglielminetti, Lorenzo; Angelini, Luciana G

    2015-01-01

    Steviol glycosides (SVglys) and gibberellins are originated from the shared biosynthesis pathway in Stevia (Stevia rebaudiana Bertoni). In this research, two experiments were conducted to study the opposing effects of external gibberellin (GA3) and Daminozide (a gibberellin inhibitor) on Stevia growth and metabolites. Results showed that GA3 significantly increased the stem length and stem dry weight in Stevia. Total soluble sugar content increased while the SVglys biosynthesis was decreased by external GA3 applying in Stevia leaves. In another experiment, the stem length was reduced by Daminozide spraying on Stevia shoots. The Daminozide did not affect the total SVglys content, while in 30 ppm concentration, significantly increased the soluble sugar production in Stevia leaves. Although the gibberellins biosynthesis pathway has previously invigorated in Stevia leaf, the Stevia response to external gibberellins implying on high precision regulation of gibberellins biosynthesis in Stevia and announces that Stevia is able to kept endogenous gibberellins in a low quantity away from SVglys production. Moreover, the assumption that the internal gibberellins were destroyed by Daminozide, lack of Daminozide effects on SVglys production suggests that gibberellins biosynthesis could not act as a competitive factor for SVglys production in Stevia leaves.

  17. EFFECT OF PLAYING TENNIS ON SHOULDER INTERNAL AND EXTERNAL ROTATION STRENGTH AND PROPRIOCEPTION

    Directory of Open Access Journals (Sweden)

    Yaşar

    2015-12-01

    Full Text Available The aim of the present study was to determine the effect of playing tennis on shoulder rotators strenght and proprioception. Ten beginner tennis players and 10 age matched sedentary controls voluntarily participated in this study. Shoulder internal and external rotators strength were evaluated by isokinetic dynamometer at a speed of 60°/sec. Shoulder proprioception was also determined by isokinetic dynamometer and assessed by measuring reproduction of passive positioning at 15º and 30º joint angles in direction of internal and external rotation. Measurements were taken before and immediately after a ten-week tennis program. In the present study, after a 10-week period, neither trained group nor the control group demonstrated significant differences in proprioceptive sense evaluations. Result supported that tennis program which continued for ten weeks has strenghtening effect on internal rotators especially on dominant shoulder. This may lead to a lowering of the strength ratio on dominant shoulder. Asymmetric sports like tennis would result in such adaptations in dominant shoulders. The decrement in strength ratio could be characterized as glenohumeral joint instability. Therefore, there should be emphasis on supplemental external strengthening exercises in the training program such group of beginner tennis players to maintain the glenohumeral stability.

  18. Evaluation of the Biological Effects of Externally Tunable, Hydrogel Encapsulated Quantum Dot Nanospheres in Escherichia coli

    Directory of Open Access Journals (Sweden)

    Somesree GhoshMitra

    2011-08-01

    Full Text Available Quantum Dots (QDs have become an interesting subject of study for labeling and drug delivery in biomedical research due to their unique responses to external stimuli. In this paper, the biological effects of a novel hydrogel based QD nano-structure on E. coli bacteria are presented. The experimental evidence reveals that cadmium telluride (CdTe QDs that are encapsulated inside biocompatible polymeric shells have reduced or negligible toxicity to this model cell system, even when exposed at higher dosages. Furthermore, a preliminary gene expression study indicates that QD-hydrogel nanospheres do not inhibit the Green Fluorescent Protein (GFP gene expression. As the biocompatible and externally tunable polymer shells possess the capability to control the QD packing density at nanometer scales, the resulting luminescence efficiency of the nanostructures, besides reducing the cytotoxic potential, may be suitable for various biomedical applications.

  19. Effects of external magnetic field on oblique propagation of ion acoustic cnoidal wave in nonextensive plasma

    Science.gov (United States)

    Farhad Kiyaei, Forough; Dorranian, Davoud

    2017-01-01

    Effects of the obliqueness and the strength of external magnetic field on the ion acoustic (IA) cnoidal wave in a nonextensive plasma are investigated. The reductive perturbation method is employed to derive the corresponding KdV equation for the IA wave. Sagdeev potential is extracted, and the condition of generation of IA waves in the form of cnoidal waves or solitons is discussed in detail. In this work, the domain of allowable values of nonextensivity parameter q for generation of the IA cnoidal wave in the plasma medium is considered. The results show that only the compressive IA wave may generate and propagate in the plasma medium. Increasing the strength of external magnetic field will increase the frequency of the wave and decrease its amplitude, while increasing the angle of propagation will decrease the frequency of the wave and increase its amplitude.

  20. The effect of interaural-level-difference fluctuations on the externalization of sound

    DEFF Research Database (Denmark)

    Catic, Jasmina; Santurette, Sébastien; Buchholz, Jörg M.

    2013-01-01

    in a standard listening room. Next, the effect of ILD fluctuations on the degree of externalization was investigated in a psychoacoustic experiment performed in the same listening room. Individual binaural impulse responses were used to simulate a distant sound source delivered via headphones. The ILDs were......Real-world sound sources are usually perceived as externalized and thus properly localized in both direction and distance. This is largely due to (1) the acoustic filtering by the head, torso, and pinna, resulting in modifications of the signal spectrum and thereby a frequency-dependent shaping...... with the analysis of short-term ILDs at different distances showing that a decreased distance to the sound source also reduced the ILD fluctuations. © 2013 Acoustical Society of America....

  1. Defect Formation in Superconducting Rings: External Fields and Finite-Size Effects

    Science.gov (United States)

    Weir, D. J.; Monaco, R.; Rivers, R. J.

    2013-06-01

    Consistent with the predictions of Kibble and Zurek, scaling behaviour has been seen in the production of fluxoids during temperature quenches of superconducting rings. However, deviations from the canonical behaviour arise because of finite-size effects and stray external fields. Technical developments, including laser heating and the use of long Josephson tunnel junctions, have improved the quality of data that can be obtained. With new experiments in mind we perform large-scale 3D simulations of quenches of small, thin rings of various geometries with fully dynamical electromagnetic fields, at nonzero externally applied magnetic flux. We find that the outcomes are, in practise, indistinguishable from those of much simpler Gaussian analytical approximations in which the rings are treated as one-dimensional systems and the magnetic field fluctuation-free.

  2. Numerical evaluation of external magnetic effect on electromagnetic wave transmission through reentry plasma layer

    Science.gov (United States)

    Zhao, Qing; Bo, Yong; Lei, Mingda; Liu, Shuzhang; Liu, Ying; Liu, Jianwei; Zhao, Yizhe

    2016-11-01

    Numerical study of electromagnetic (EM) wave transmission through the magnetized plasma layer is presented in this paper. The plasma parameters are derived from computational fluid dynamics simulation of the flow field around a blunt body flying at supersonic speed and serve as the background plasma condition in the numerical modeling for EM wave transmission. The EM wave is generated by our newly designed coaxial feed GPS patch antenna. The external magnetic field is applied and assumed to vary linearly as a function of wall distance. The effects of the external applied magnetic field and the plasma parameters on wave transmission are studied, and the results show that EM wave propagation in the non-uniformly magnetized plasma is a matter of impedance matching, and the EM wave transmission can be adjusted only when the proper strength of the magnetic field is applied.

  3. An easy protocol for the domino synthesis of diversely functionalized spirocarbocycles and their biological evaluation

    Indian Academy of Sciences (India)

    Selvarangam E Kiruthika; Paramasivan T Perumal; C Balachandran; S Ignacimuthu

    2014-01-01

    A base-catalysed domino reaction for the synthesis of spirocarbocycles in excellent yields using chalcones and vinyl malononitriles is reported. This consists of a series of steps including Knoevenagel condensation followed by intermolecular vinylogous Michael addition and intramolecular cyclization. The synthesized compounds were evaluated for their antimicrobial activity and the compounds exhibited moderate to excellent activities.

  4. Pizza Hut, Domino's, and the Public Schools: Making Sense of Commercialization.

    Science.gov (United States)

    Stark, Andrew

    2001-01-01

    Describes different types of partnerships between schools and businesses, discussing the benefits of and drawbacks to the commercial aspects of programs like Pizza Hut's, in which children who read a certain number of books receive free pizza, and programs like Dominos', in which schools receive materials or money in return for students buying…

  5. Analytic approach to stochastic cellular automata: exponential and inverse power distributions out of Random Domino Automaton

    CERN Document Server

    Bialecki, Mariusz

    2010-01-01

    Inspired by extremely simplified view of the earthquakes we propose the stochastic domino cellular automaton model exhibiting avalanches. From elementary combinatorial arguments we derive a set of nonlinear equations describing the automaton. Exact relations between the average parameters of the model are presented. Depending on imposed triggering, the model reproduces both exponential and inverse power statistics of clusters.

  6. Domino Server System Design%Domino服务器系统设计

    Institute of Scientific and Technical Information of China (English)

    刘跃

    2015-01-01

    This paper mainly introduces the design of Domino OA server system,including its installation and configu-ration method.%本文主要介绍OA Domino服务器系统设计,内容包括其安装与配置方法。

  7. Domino [Pd]-Catalysis: One-Pot Synthesis of Isobenzofuran-1(3H)-ones.

    Science.gov (United States)

    Mahendar, Lodi; Satyanarayana, Gedu

    2016-09-02

    An efficient domino [Pd]-catalysis for the synthesis of isobenzofuran-1(3H)-ones is presented. The strategy shows broad substrate scope and is amenable to o-bromobenzyl tertiary/secondary/primary alcohols. Significantly, the method was applied to the synthesis of antiplatelet drug n-butyl phthalide and cytotoxic agonist 3a-[4'-methoxylbenzyl]-5,7-dimethoxyphthalide.

  8. Dominos in the dairy: An analysis of transgenic maize in Dutch dairy farming

    NARCIS (Netherlands)

    Groeneveld, R.A.; Wesseler, J.H.H.; Berentsen, P.B.M.

    2013-01-01

    EU member states require farmers growing transgenic maize to respect a minimum distance from fields with non-transgenic maize. Previous studies have theoretically argued that such minimum distance requirements may lead to a so-called ‘domino effect’ where farmers who want to grow transgenic maize

  9. Domino reactions of 2-methyl chromones containing an electron withdrawing group with chromone-fused dienes.

    Science.gov (United States)

    Gong, Jian; Xie, Fuchun; Ren, Wenming; Chen, Hong; Hu, Youhong

    2012-01-21

    Domino reactions of 2-methyl substituted chromones containing an electron withdrawing group at the 3-position with chromone-fused dienes synthesized a diverse range of benzo[a]xanthones and complicated chromone derivatives. These multiple-step reactions result in either two or three new C-C bonds without a transition metal catalyst or an inert atmosphere.

  10. A general approach to aza-heterocycles by means of domino sequences driven by hydroformylation.

    Science.gov (United States)

    Airiau, Etienne; Spangenberg, Thomas; Girard, Nicolas; Schoenfelder, Angèle; Salvadori, Jessica; Taddei, Maurizio; Mann, André

    2008-01-01

    The development of hydroformylative domino reactions of easily accessible vinyl acetamides is described. Extremely regioselective hydroformylation of terminal double bounds provides a transient N-acyliminium that can be trapped by various nucleophiles to give several aza-heterocylic scaffolds in a diastereoselective manner.

  11. Consecutive One-Pot versus Domino Multicomponent Approaches to 3-(Diarylmethylene)oxindoles.

    Science.gov (United States)

    Park, Sunhwa; Lee, Jiyun; Shin, Kye Jung; Oh, Euichaul; Seo, Jae Hong

    2017-03-22

    Based on consecutive one-pot conditions combining three palladium-catalyzed reactions (Sonogashira, Heck and Suzuki-Miyaura reactions), a more efficient domino multicomponent method has been successfully developed to access a wide variety of 3-(diarylmethylene)oxindoles. Microwave irradiation and use of a silver salt were the most important factors to achieve high yields and stereoselectivity.

  12. Copper(I-BINOL Catalyzed Domino Synthesis of 1,4-Benzoxathiines through (-O Bond Formation

    Directory of Open Access Journals (Sweden)

    Chiranjeevi Korupalli

    2011-01-01

    Full Text Available 1,4-benzoxathiine moieties can be synthesized by domino SN2 ring opening of epoxide with o-halothiophenols followed by the copper(I-BINOL catalyzed Ullmann-type coupling cyclization (intramolecular C(aryl-O bond formation with moderate to good yields.

  13. Facile synthesis of functionalized tetrahydroquinolines via domino Povarov reactions of arylamines, methyl propiolate and aromatic aldehydes

    Directory of Open Access Journals (Sweden)

    Jing Sun

    2012-10-01

    Full Text Available In the presence of p-toluenesulfonic acid as catalyst the domino reaction of arylamines, methyl propiolates and aromatic aldehydes in ethanol proceeded smoothly to give polysubstituted 1,2,3,4-tetrahydroquinolines in moderate yields. The reaction is believed to involve the Povarov reaction of in situ generated β-enamino ester with the in situ formed aromatic imine.

  14. Pizza Hut, Domino's, and the Public Schools: Making Sense of Commercialization.

    Science.gov (United States)

    Stark, Andrew

    2001-01-01

    Describes different types of partnerships between schools and businesses, discussing the benefits of and drawbacks to the commercial aspects of programs like Pizza Hut's, in which children who read a certain number of books receive free pizza, and programs like Dominos', in which schools receive materials or money in return for students buying…

  15. Meteorology during the DOMINO campaign and its connection with trace gases and aerols

    NARCIS (Netherlands)

    Adame, J.A.; Martinez, M.; Sorribas, M.; Hidalgo, P.J.; Vilà-Guerau de Arellano, J.

    2014-01-01

    The DOMINO (Diel Oxidant Mechanisms in relation to Nitrogen Oxides) campaign was carried out from 21 November to 8 December 2008 at the El Arenosillo station (SW of Spain) in a coastal-rural environment. The main weather conditions are analysed using local meteorological variables, meteorological

  16. A case of the hepatic hilar bile duct cancer with external radiation. Efficacy and severe side effect of external radiation therapy

    Energy Technology Data Exchange (ETDEWEB)

    Andoh, Hideaki; Yasui, Ouki; Ise, Norihito [Akita Univ. (Japan). School of Medicine

    2003-04-01

    Hepatic hilar bile duct cancer was difficult to cure by surgical treatment and its prognosis was very poor. We present the case of non-curative resection of hepatic hilar bile duct cancer, controlled with external radiation. 72 years-old-female, she complained jaundice and diagnosed hepatic hilar bile duct cancer with abdominal ultrasonography. Hepatic hilar resection was performed but curative resection could not be done, because cancer was diffusely spreaded to the hepatic and duodenal ends of the bile duct. After surgery, external radiation (1.8 Gy/day; total 50.4 Gy) was performed. Three months after operation, sometimes, cholangitis was occurred but we could not detect the intrahepatic bile duct dilatation and improved with antibiotics. After seven months, she was dead for sepsis, liver abscess and biliary cirrhosis. From autopsy findings, severe hepatic hilar fibrosis around the irradiation area, stenosis of the hepatico-jejunostomy and portal vein were existed but could not detect the remnant cancer cells. External radiation was sometimes effective, especially for this case. But we should consider the side effect of fibrosis and preventive treatments such as biliary stenting or early biliary drainage. (author)

  17. Evaluation of the Curative Effect of External Beam Radiotherapy and Brachytherapy for Tongue Carcinoma

    Institute of Scientific and Technical Information of China (English)

    Ping Wang; Qingsong Pang

    2007-01-01

    OBJECTIVE To evaluate the curative effect of external beam radiotherapy (EBRT) and brachytherapy (BT) for tongue carcinoma. METHODS From 1991 to 2003, 35 patients received EBRT and BT in our department. We analyzed their curative and side effects retrospectively. RESULTS Local control was 80%. The 3-year overall (OS) and disease specific survival (DSS) rates were 75% and 79%. One patient developed metastases. Three patients (9%) developed different late complications. CONCLUSIONS Local regional control, survival, and complications in patients with tongue carcinoma treated by EBRT and BT have been satisfactory.

  18. On water: silver-catalyzed domino approach for the synthesis of benzoxazine/oxazine-fused isoquinolines and naphthyridines from o-alkynyl aldehydes.

    Science.gov (United States)

    Verma, Akhilesh K; Choudhary, Deepak; Saunthwal, Rakesh K; Rustagi, Vineeta; Patel, Monika; Tiwari, Rakesh K

    2013-07-01

    An operationally simple domino approach for the silver-catalyzed synthesis of oxazine/benzoxazine-fused isoquinolines 5a-q and naphthyridines 6a-v by the reaction of o-alkynyl aldehydes 3a-aa with amines having embedded nucleophiles 4a-d under mild reaction condition in water is described. The reaction shows selective C-N bond formation on the more electrophilic alkynyl carbon resulting in the formation of 6-endo-dig cyclized product. The competitive experiments show the viability of an intramolecular nucleophilic attack over an intermolecular attack of the external nucleophile. This methodology accommodates wide functional group variation, which proves to be useful for structural and biological assessment.

  19. Two-dimensional model colloids and nano wires: phase transitions, effects of external potentials and quantum effects

    Science.gov (United States)

    Franzrahe, K.; Henseler, P.; Ricci, A.; Strepp, W.; Sengupta, S.; Dreher, M.; Kircher, Chr.; Lohrer, M.; Quester, W.; Binder, K.; Nielaba, P.

    2005-07-01

    Quantum effects, structures and phase transitions in Nano-systems have been analyzed. An overview is given on the results of our computations on structural and elastic properties of model colloids, on phase transitions of model colloids in external fields, and on structural and electronic properties of stretched atomic wires.

  20. The effect of the external medium on the gravitropic curvature of rice (Oryza sativa, Poaceae) roots

    Science.gov (United States)

    Staves, M. P.; Wayne, R.; Leopold, A. C.

    1997-01-01

    The roots of rice seedlings, growing in artificial pond water, exhibit robust gravitropic curvature when placed perpendicular to the vector of gravity. To determine whether the statolith theory (in which intracellular sedimenting particles are responsible for gravity sensing) or the gravitational pressure theory (in which the entire protoplast acts as the gravity sensor) best accounts for gravity sensing in rice roots, we changed the physical properties of the external medium with impermeant solutes and examined the effect on gravitropism. As the density of the external medium is increased, the rate of gravitropic curvature decreases. The decrease in the rate of gravicurvature cannot be attributed to an inhibition of growth, since rice roots grown in 100 Osm/m3 (0.248 MPa) solutions of different densities all support the same root growth rate but inhibit gravicurvature increasingly with increasing density. By contrast, the sedimentation rate of amyloplasts in the columella cells is unaffected by the external density. These results are consistent with the gravitational pressure theory of gravity sensing, but cannot be explained by the statolith theory.

  1. The Effects of Externally Solidified Product on Wave Celerity and Quality of Die Cast Products

    Energy Technology Data Exchange (ETDEWEB)

    Carroll Mobley; Yogeshwar Sahai; Jerry Brevick

    2003-10-10

    The cold chamber die casting process is used to produce essentially all the die cast aluminum products and about 50% of the die cast magnesium products made today. Modeling of the cold chamber die casting process and metallographic observations of cold chamber die cast products indicate that typically 5 to 20% of the shot weight is solidified in the shot sleeve before or during cavity filling. The protion of the resulting die casting which is solidified in the shot sleeve is referred to as externally solidified product, or, when identified as a casting defect, as cold flakes. This project was directed to extending the understanding of the effects of externally solidified product on the cold chamber die casting process and products to enable the production of defect-free die castings and reduce the energy associated with these products. The projected energy savings from controlling the fraction of externally solidified product in die cast components is 40 x 10 Btu through the year 2025.

  2. The Effect of External Magnetic Fields on the MRT Instability in MagLIF

    Science.gov (United States)

    Hess, Mark; Peterson, Kyle; Weis, Matthew; Lau, Yue Ying

    2014-10-01

    Recent experiments on MagLIF which incorporate an external B-field suggest that the MRT instability within the liner has a different behavior than without the B-field. Previous work by Chandrasekhar and Harris have illustrated how the MRT growth rate, assuming fixed liner density and fixed acceleration, can change due to the presence of an external B-field. In this work, we show how the growth rate of the MRT instability is dynamically affected by the rapidly varying acceleration, liner density, and surface magnetic field, which is composed of the external B-field and the drive B-field of the liner in the MagLIF experiments. In addition, we also examine the effects of finite liner resistivity on MRT growth, which gives rise to an additional time scale corresponding to magnetic diffusion. We discuss the implications of this result for future MagLIF designs. Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE-AC04-94AL85000.

  3. The effect of internal and external focus of attention on game performance in tennis

    Directory of Open Access Journals (Sweden)

    Marina Tsetseli

    2016-12-01

    Full Text Available Background: Great importance has been given in recent years to the impact of focus of attention cues during skills execution but not during real game play, where more cognitive skills are involved besides technical performance. Objective: The purpose of the present study was to examine the effect of internal and external focus of attention instructions on the components of the game performance (decision making, skill execution, base in tennis. Methods: The participants (N = 60 were divided into three groups and followed an intervention training program that lasted 6 weeks; IF group (n = 20 under internal focus of attention instructions, EF group (n = 20 under external focus of attention instructions and CON group (n = 20 under no attentional focus instructions. Three measurements took place (pre, post and ret in which the participants were recorded on video while playing matches in real scoring conditions. Game Performance Assessment Instrument (GPAI was used to evaluate the components of game performance in tennis in three game situations; service, return of the service, base line game. Results: ANOVA repeated measures in a 3 (groups: IF, EF & CON × 3 (measurements: pre, post, ret revealed a significant interaction between groups and measurements and post hoc analysis indicated that the group that was instructed to focus externally improved significantly only in decision making compared to the internal focus of attention and to the control group. The score difference was maintained at the retention test as well, which indicates that the impact concerned not only performance but also learning. Conclusions: Instructions that aim to an external focus of attention enhance decision making skills, which are considered the most important element of game performance in tennis.

  4. Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions

    Science.gov (United States)

    Held, Felix E.; Guryev, Anton A.; Fröhlich, Tony; Hampel, Frank; Kahnt, Axel; Hutterer, Corina; Steingruber, Mirjam; Bahsi, Hanife; von Bojničić-Kninski, Clemens; Mattes, Daniela S.; Foertsch, Tobias C.; Nesterov-Mueller, Alexander; Marschall, Manfred; Tsogoeva, Svetlana B.

    2017-05-01

    Most of the known approved drugs comprise functionalized heterocyclic compounds as subunits. Among them, non-fluorescent quinazolines with four different substitution patterns are found in a variety of clinically used pharmaceuticals, while 4,5,7,8-substituted quinazolines and those displaying their own specific fluorescence, favourable for cellular uptake visualization, have not been described so far. Here we report the development of a one-pot synthetic strategy to access these 4,5,7,8-substituted quinazolines, which are fluorescent and feature strong antiviral properties (EC50 down to 0.6+/-0.1 μM) against human cytomegalovirus (HCMV). Merging multistep domino processes in one-pot under fully metal-free conditions leads to sustainable, maximum efficient and high-yielding organic synthesis. Furthermore, generation of artesunic acid-quinazoline hybrids and their application against HCMV (EC50 down to 0.1+/-0.0 μM) is demonstrated. Fluorescence of new antiviral hybrids and quinazolines has potential applications in molecular imaging in drug development and mechanistic studies, avoiding requirement of linkage to external fluorescent markers.

  5. Effect of external stress on phase diagrams and dielectric properties of epitaxial ferroelectric thin films grown on orthorhombic substrates

    Institute of Scientific and Technical Information of China (English)

    L(U) Ye-gang; DENG Shui-feng; GONG Lun-jun; YANG Jian-tao

    2006-01-01

    A Landau-Ginsburg-Devonshire(LD)-type thermodynamic theory was used to describe the effect of external stress on phase diagrams and dielectric properties of epitaxial ferroelectric thin films grown on orthorhombic substrates which induce nonequally biaxial misfit strains in the films plane. The "misfit strain-external stress" and "external stress-temperature" phase diagrams were constructed for single-domain BaTiO3(BT) and PbTiO3(PT) thin films. It is shown that the external stress may lead to the rotation of the spontaneous polarization and a gradual change of its magnitude, which may result in phase transition. Nonequally biaxial misfit strains dependence of the stability of polarization states may be governed by external stress. At room temperature,stress-induced ferroelectric/paraelectric phase transition which occurs in film on cubic substrate does not take place in the ferroelectric thin film grown on orthorhombic substrate. It is also shown that the nonequally misfit strains in the film plane may lead to the appearance of new phases which do not form in films grown on cubic substrates under external stress. The dependence of the dielectric response on the external stress is also studied. It is shown that the dielectric constants of single-domain PT and BT films are very sensitive to the external stress under the given anisotropic misfit strains-temperature conditions. It presents theoretical evidence that the external stress and anisotropic misfit strains can be employed for improving the thin films physical properties.

  6. Evaluation of Cost and Effectiveness of Decontamination Scenarios on External Radiation Exposure in Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Yasutaka, T.; Naito, W. [National Institute of Advanced Industrial Science and Technology (Japan)

    2014-07-01

    Despite the enormous cost associated with radiation decontamination, almost no quantitative assessment has been performed on the relationship between the potential reduction in long-term radiation exposure and the costs of the various decontamination strategies considered for the decontamination areas in Fukushima. In order to establish effective and pragmatic decontamination strategies for use in the radiation contaminated areas in Fukushima, a holistic approach for assessing decontamination strategies, their costs, and long-term external radiation doses is needed. The objective of the present study is to evaluate the cost and effectiveness of decontamination scenarios in the decontamination areas in Fukushima in regard to external radiation exposure. The choice of decontamination strategies in the decontamination areas should be based on a comprehensive analysis of multiple attributes such as radiological, economic, and socio-psychological attributes. The cost and effectiveness of the different decontamination strategies is not sole determinant of the decontamination strategies of the special decontamination area but is one of the most important attributes when making the policy decision. In the current study, we focus on radiological and economic attributes in determining decontamination strategies. A geographical information system (GIS) was used to relate the predicted external dose in the affected areas to the number of potential inhabitants and the land use in the areas. A comprehensive review of the costs of various decontamination methods was conducted as part of the analysis. The results indicate that aerial decontamination in the special decontamination areas in Fukushima would be effective for reducing the air dose rate to the target level in a short period of time in some but not all of the areas. In a standard scenario, the analysis of cost suggests that decontamination costs of decontamination in Fukushima was estimated to be up to approximately 5

  7. Effects of confinement and external fields on structure and transport in colloidal dispersions in reduced dimensionality.

    Science.gov (United States)

    Wilms, D; Deutschländer, S; Siems, U; Franzrahe, K; Henseler, P; Keim, P; Schwierz, N; Virnau, P; Binder, K; Maret, G; Nielaba, P

    2012-11-21

    In this work, we focus on low-dimensional colloidal model systems, via simulation studies and also some complementary experiments, in order to elucidate the interplay between phase behavior, geometric structures and transport properties. In particular, we try to investigate the (nonlinear!) response of these very soft colloidal systems to various perturbations: uniform and uniaxial pressure, laser fields, shear due to moving boundaries and randomly quenched disorder. We study ordering phenomena on surfaces or in monolayers by Monte Carlo computer simulations of binary hard-disk mixtures, the influence of a substrate being modeled by an external potential. Weak external fields allow a controlled tuning of the miscibility of the mixture. We discuss the laser induced de-mixing for the three different possible couplings to the external potential. The structural behavior of hard spheres interacting with repulsive screened Coulomb or dipolar interaction in 2D and 3D narrow constrictions is investigated using Brownian dynamics simulations. Due to misfits between multiples of the lattice parameter and the channel widths, a variety of ordered and disordered lattice structures have been observed. The resulting local lattice structures and defect probabilities are studied for various cross sections. The influence of a self-organized order within the system is reflected in the velocity of the particles and their diffusive behavior. Additionally, in an experimental system of dipolar colloidal particles confined by gravity on a solid substrate we investigate the effect of pinning on the dynamics of a two-dimensional colloidal liquid. This work contains sections reviewing previous work by the authors as well as new, unpublished results. Among the latter are detailed studies of the phase boundaries of the de-mixing regime in binary systems in external light fields, configurations for shear induced effects at structured walls, studies on the effect of confinement on the structures

  8. The Domino Effect, or Why Literacy Depends on All Libraries.

    Science.gov (United States)

    Gorman, Michael

    1995-01-01

    Discusses the results of the California "Tax Revolt," specifically Proposition 13, on public services. Examines the relationship between declining literacy levels and a lack of library skills; and proposes a program where libraries and schools can work together to restore library funding, adapt library instruction, and promote literacy. (AEF)

  9. The Domino Effect, or Why Literacy Depends on All Libraries.

    Science.gov (United States)

    Gorman, Michael

    1995-01-01

    Discusses the results of the California "Tax Revolt," specifically Proposition 13, on public services. Examines the relationship between declining literacy levels and a lack of library skills; and proposes a program where libraries and schools can work together to restore library funding, adapt library instruction, and promote literacy.…

  10. Synthetic studies on taxanes: A domino-enyne metathesis/Diels-Alder approach to the AB-ring

    Indian Academy of Sciences (India)

    Krishna P Kaliappan; Velayutham Ravikumar; Sandip A Pujari

    2008-01-01

    A domino enyne cross-metathesis/intramolecular Diels-Alder reaction has been successfully used to synthesize a bicyclo[5.3.1] undecene, corresponding to AB-ring of taxol without the gem dimethyl group.

  11. 基于Lotus Domino平台的系统安全%System Security Based on Lotus Domino Platform

    Institute of Scientific and Technical Information of China (English)

    邓海潮

    2012-01-01

    阐述了Domino安全标准准则,分析了Domino/Notes平台的安全性,研究该平台用户标识符、检验字、交叉认证技术和数字签名原理,剖析了该平台多层次的安全模型,解释了Domino的安全配置问题。%This paper presents the guidelines for Domino safety standards, analyzes the security of Domino / Notes platform, and studies the platform's user identifier, test words, cross-certification technology and digital signature principle. In-depth analysis is also conducted as to the platform's multi-level security model and explanation is made as to Domino safe configuration.

  12. The Effect of Institutions on the External Financing of The Brazilian Firms

    Directory of Open Access Journals (Sweden)

    Antonio Gledson De Carvalho

    2009-01-01

    Full Text Available Based on an analysis across Brazilian states, this article investigates whether the level of institutional development affects the pattern of external financing of firms. The analysis is based on a unique dataset stratified across firms from 10 to 10,500 employees (of which 71.9 percent are micro and small firms, 13 Brazilian states and 9 industries. Our main results indicate that lack institutional development – measured through corruption and efficiency of the judicial system and financial development – makes the use of bank credit and formal sources less frequent. Moreover, this effect seems to be stronger for small firms.

  13. Modeling of external electric field effect on the carbon and silicon carbide nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Sorokina, Veronika, E-mail: ansonika@mail.ru [Saint Petersburg State University, 7/9 Universitetskaya nab., St. Petersburg, 199034 (Russian Federation); Nikiforov, Konstantin, E-mail: knikiforov@cc.spbu.ru [Saint Petersburg Electrotechnical University “LETI”, 5 Prof. Popova, St. Petersburg, 197376 (Russian Federation)

    2016-06-17

    Studying emission characteristics of nanotubes is extremely important for development of electronics. Compared to other electron sources nanotube-based field emitters allow obtaining significant emission currents at relatively low values of the applied field. It is possible due to their unique structure. This article is devoted to theoretical investigation how external electric field effects several samples of open single-wall nanotubes from carbon and silicon carbide. Total energies, dipole moments and band gaps for five types of nanotubes were calculated from the first principles. The numerical experiment results indicate the adequacy of modeling. It was concluded that considered configurations of achiral carbon nanotubes should be semiconductors.

  14. Effects of external fields on two-dimensional Klein-Gordon particle under pseudoharmonic oscillator interaction

    CERN Document Server

    Ikhdair, Sameer M

    2012-01-01

    We study the effects of the perpendicular magnetic and Aharonov-Bohm (AB) flux fields on the energy levels of a two-dimensional (2D) Klein-Gordon (KG) particle subjects to equal scalar and vector pseudo-harmonic oscillator (PHO). We calculate the exact energy eigenvalues and normalized wave functions in terms of chemical potential parameter, magnetic field strength, AB flux field and magnetic quantum number by means of the Nikiforov-Uvarov (NU) method. The non-relativistic limit, PHO and harmonic oscillator solutions in the existence and absence of external fields are also obtained.

  15. The effectiveness study of the physiotherapy techniques with infiltrative pulmonary tuberculosis using external respiration indicators

    Directory of Open Access Journals (Sweden)

    Kalmykova Y.S.

    2012-02-01

    Full Text Available The results of the study of respiratory function of patients with infiltrative pulmonary tuberculosis to assess the ventilation ability of the lungs, as well as the presence and degree of ventilation violations. Indicated the need to examine the results of studies of lung function in these patients in order to timely correction of violations. It is established that therapeutic exercises with financial astrophysical exercises with elements of yoga postures, combined with yogic breathing exercises, as well as regulated breathing exercises, taking into account the tone of the sympathetic and parasympathetic nervous systems and measured distance is an effective and significantly improves functional indices of external respiration.

  16. Effects of the availability of an external area on dairy cows welfare during summer period

    Directory of Open Access Journals (Sweden)

    L. Stefanini

    2011-03-01

    Full Text Available Problems of environmental pollution, as well as the need to ensure the cleanliness of the milking cows, do not suggest the use of external paddock. On the contrary, for the production of organic milk, the access to the paddock or pasture is compulsory, as the presence of the paddock could improve animal welfare, particularly in hot summer conditions. The negative effects of heat stress are not simply restricted to a lower milk yield but also lead to a worsening of milk composition (Bernabucci and Calamari, 1998 and cheesemaking properties (Calamari and Mariani, 1998.....

  17. On the Correct Formulation of the Law of the External Photoelectric Effect

    Science.gov (United States)

    Kalanov, Temur Z.

    2017-01-01

    The critical and correct scientific analysis of the generally accepted theory of the external photoelectric effect is proposed. The methodological basis for the analysis is the unity of formal logic and of rational dialectics. It is shown that Einstein's formulation of the law of the photoelectric effect is not free from the following objection. The terms of Einstein's formula characterize the quantitative determinacy (i.e., energy) which belongs and is related to the different material objects: ``photon'', ``electron in metal'', and ``electron not in metal''. This signifies that Einstein's formula represents violation of the formal-logical laws of identity and absence (lack) of contradiction. The correct mathematical formulation of the law of the external photoelectric effect within the framework of the system approach is proposed. The correct formulation represents the proportion by relative increments of the energy of the incident photon and the energy of the emitted electron. The proportion describes the linear relationship between the energy of the incident photon and the energy of the emitted electron.

  18. Effects of Qi therapy (external Qigong) on symptoms of advanced cancer: a single case study.

    Science.gov (United States)

    Lee, M S; Yang, S H; Lee, K K; Moon, S-R

    2005-12-01

    The aim of this study was to examine the effectiveness of Qi therapy (external Qigong) in the management of symptoms of advanced cancer in a man. We used a single case study design to evaluate the effectiveness of Qi therapy (external Qigong) in a 35-year-old man with advanced cancer (Stage IV) involving metastases in the stomach, lung and bone (Karnofsky performance scale: KPS, 40: requires special care and assistance, disabled). Treatment involved six days of pre-assessment, eight treatment sessions on alternate days over 16 days, and a two-week follow-up phase. A visual analogue scale (VAS) was used to assess the patient's self-reported symptoms of cancer over the intervention and follow-up periods. Following treatment, VAS scores' analysis revealed beneficial effects on pain, vomiting, dyspnoea, fatigue, anorexia, insomnia, daily activity and psychological calmness. These improvements were maintained over the two-week follow-up phase. After the first Qi therapy session, the patient discontinued medication and could sit by himself; after the fourth session, the patient was able to walk and use the toilet without assistance (improvement in KPS: 70: care for self, unable to perform normal activity or to do active work). Although limited by the single case study approach, our results support previous studies on this topic and provide reasons to conduct controlled clinical trials.

  19. 基于Lotus Domino的Intranet构建技术%The techology of building intranet with lotus domino

    Institute of Scientific and Technical Information of China (English)

    金飚; 陈传波

    2001-01-01

    通过一个具体的实例,讨论了Lotus Domino的特点,并给出了基于Lotus Domino的Intranet构建方法及关键技术,为企业的Intranet建设提供了参考和借鉴.%The specialities of Lotus Domino and the method of building Intranet based on Lotus Domino by an instance were discussed in this paper, These experiences are very useful for the building of Intranet.

  20. Organocatalytic Asymmetric Synthesis of Functionalized 1,3,5-Triarylpyrrolidin-2-ones via an Aza-Michael/Aldol Domino Reaction.

    Science.gov (United States)

    Joie, Céline; Deckers, Kristina; Enders, Dieter

    2014-03-01

    The organocatalytic asymmetric synthesis of functionalized 1,3,5-triarylpyrrolidin-2-ones bearing three contiguous stereocenters through an aza-Michael/aldol domino reaction of α-ketoamides with α,β-unsaturated aldehydes is described. The domino products were further derivatized by aldehyde olefination under one-pot conditions. The reaction proceeds with excellent diastereoselectivities (>20:1) and good to excellent enantioselectivities (60-96% ee).

  1. Effects of External Magnetic Fields on the Excited States of (ND)8 Metal Complexes.

    Science.gov (United States)

    Helms, Charles Alan

    Large changes in the steady state emissions and lifetimes as a function of external magnetic field strength have been observed for (nd)^8 mononuclear and binuclear complexes. These unusually pronounced effects are attributed to a field-induced symmetry reduction leading to a relaxation of transition dipole selection rules. Both spin-orbit coupling and magnetic field strength appear to play a role in determining the magnitude of the observed effect. A theoretical model has been developed to rationalize the results obtained for the Pt_2(H _2P_2O _5)_sp{4}{4-} ion. An analogous model should pertain to the mononuclear systems. Closed-shell (La(III), Lu(III)) rare earth salts of the Pt_2(H_2P _2O_5)_sp{4 }{4-} ion show the same dependence on an externally applied magnetic field as the previously examined K and Ba analogs, in all respects. However, the luminescence properties of the openshell salts are markedly different, even in the absence of a magnetic field. The zero-field phosphorescence lifetime of GdKPt_2 (H_2P_2O _5)_4 is one-tenth that of the closed-shell lifetime, but the position of the phosphorescence is unchanged from the closed-shell case. The application of an external magnetic field produces no further changes in the electronic properties of the open-shell salts. Salts containing rare earth ions with low-lying atomic states (Eu(III)) exhibit complete quenching of the Pt _2(H_2P_2 O_5)_sp{4}{4 -} phosphorescence, indicating efficient energy transfer. Results from complexes containing rare earth ions are analyzed in terms of an angular momentum coupling scheme. A recently published derivation of basis functions for the Pt_2(H_2 P_2O_5)_sp {4}{4-} ion including spin-orbit interactions was repeated and confirmed.

  2. Effect of Diving and Diving Hoods on the Bacterial Flora of the External Ear Canal and Skin

    Science.gov (United States)

    1982-05-01

    NAVAL MEDICAL RESEARCH INSTITUTE BETHESDA, MARYLAND 82-22 EFFECT OF DIVING AND DIVING HOODS ON THE BACTERIAL FLORA OF THE EXTERNAL EAR CANAL AND SKIN...Subtitle) 5. TYPE OF REPeRT & PERIOD COVERED EFFECT OF DIVING AND DIVING HOODS ON THE BACTERIAL - PROGRESS FLORA OF THE EXTERNAL EAR CANAL AND SKIN MEDICAL...bacterial flora of the external ear canals and posterior auricular skin surface was investigated’in a group of 26 divers after 25 dry-suit dives in harbor

  3. Effective Response of Nonlinear Composite under External AC and DC Electric Field

    Institute of Scientific and Technical Information of China (English)

    LIU Ye; LIANG Fang-Chu; SHEN Hong-Liang

    2005-01-01

    A perturbation method is used to study effective response of nonlinear Kerr composites, which are subject to the constitutive relation of electric displacement and electric field, Dα = εαE + xα|E|2E. Under the external AC and DC electric field Eapp = Eα(1 + sinwt), the effective nonlinear responses and local potentials are induced by the cubic nonlinearity of Kerr materials at all harmonics. As an example in three dimensions, we have investigated this kind of nonlinear composites with spherical inclusions embedded in a host. At all harmonic frequencies, the potentials in inclusion and host regions are derived. Furthermore, the formulae of the effective linear and nonlinear responses are given in the dilute limit.

  4. Effect of external and internal magnetic fields on the bias stability in a Zeeman laser gyroscope

    Energy Technology Data Exchange (ETDEWEB)

    Kolbas, Yu Yu; Saveliev, I I; Khokhlov, N I [Open Joint-Stock Company M.F. Stel' makh Polyus Research Institute, Moscow (Russian Federation)

    2015-06-30

    With the specific features of electronic systems of a Zeeman laser gyroscope taken into account, the basic physical mechanisms of the magnetic field effect on the bias stability and the factors giving rise to the internal magnetic fields are revealed. The hardware-based methods of reducing the effect of external and internal magnetic fields are considered, as well as the algorithmic methods for increasing the stability of the bias magnetic component by taking into account its reproducible temperature and time dependences. Typical experimental temperature and time dependences of the magnetic component of the Zeeman laser gyro bias are presented, and by their example the efficiency of the proposed methods for reducing the effect of magnetic fields is shown. (laser gyroscopes)

  5. The Effect of External Loads and Cyclic Loading on Normal Patellofemoral Joint Signals.

    Directory of Open Access Journals (Sweden)

    K. O. Ladly

    1993-07-01

    Full Text Available Pain over the anterior portion of the knee joint is a common clinical complaint. A condition known as 'chondromalacia patella' (softening of the cartilage under the patella, which frequently causes anterior knee pain is difficult to diagnose and monitor. Vibrations detected by a contact transducer over the patellofemoral joint may be useful in the assessment of chondromalacia patella. This paper utilised this technique known as vibroarthrography (VAG, to study two potential sources of variability of the normal patellofemoral joint signal. The effect of increased muscular force on the VAG signal was measured by externally loading the joint. The effect of load history (cyclic loading on the VAG signal was determined by comparing signals before, during, and after application of weights under similar cyclic loading conditions. Results indicated that external loading of the patellofemoral joint caused only minor signal variation. Cyclical loading of the joint, on the other hand, was determined to be a major source of variability of the normal patellofemoral joint signal, which must be controlled in future VAG tests.

  6. Effect of external auditory pacing on the neural activity of stuttering speakers.

    Science.gov (United States)

    Toyomura, Akira; Fujii, Tetsunoshin; Kuriki, Shinya

    2011-08-15

    External auditory pacing, such as metronome sound and speaking in unison with others, has a fluency-enhancing effect in stuttering speakers. The present study investigated the neural mechanism of the fluency-enhancing effect by using functional magnetic resonance imaging (fMRI). 12 stuttering speakers and 12 nonstuttering controls were scanned while performing metronome-timed speech, choral speech, and normal speech. Compared to nonstuttering controls, stuttering speakers showed a significantly greater increase in activation in the superior temporal gyrus under both metronome-timed and choral speech conditions relative to a normal speech condition. The caudate, globus pallidus, and putamen of the basal ganglia showed clearly different patterns of signal change from rest among the different conditions and between stuttering and nonstuttering speakers. The signal change of stuttering speakers was significantly lower than that of nonstuttering controls under the normal speech condition but was raised to the level of the controls, with no intergroup difference, in metronome-timed speech. In contrast, under the chorus condition the signal change of stuttering speakers remained lower than that of the controls. Correlation analysis further showed that the signal change of the basal ganglia and motor areas was negatively correlated with stuttering severity, but it was not significantly correlated with the stuttering rate during MRI scanning. These findings shed light on the specific neural processing of stuttering speakers when they time their speech to auditory stimuli, and provide additional evidence of the efficacy of external auditory pacing. Copyright © 2011 Elsevier Inc. All rights reserved.

  7. Effects of aqueous humor hydrodynamics on human eye heat transfer under external heat sources.

    Science.gov (United States)

    Tiang, Kor L; Ooi, Ean H

    2016-08-01

    The majority of the eye models developed in the late 90s and early 00s considers only heat conduction inside the eye. This assumption is not entirely correct, since the anterior and posterior chambers are filled aqueous humor (AH) that is constantly in motion due to thermally-induced buoyancy. In this paper, a three-dimensional model of the human eye is developed to investigate the effects AH hydrodynamics have on the human eye temperature under exposure to external heat sources. If the effects of AH flow are negligible, then future models can be developed without taking them into account, thus simplifying the modeling process. Two types of external thermal loads are considered; volumetric and surface irradiation. Results showed that heat convection due to AH flow contributes to nearly 95% of the total heat flow inside the anterior chamber. Moreover, the circulation inside the anterior chamber can cause an upward shift of the location of hotspot. This can have significant consequences to our understanding of heat-induced cataractogenesis. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

  8. Effects of external loading on lumbar extension moment during squat lifting

    Directory of Open Access Journals (Sweden)

    Iman Vahdat

    2017-08-01

    Full Text Available Objectives: The main objective of this study has been qualitative investigation of the effects of external loading on the lumbar extension moment during squat lifting. Findings of this study may allow to determine the factor with the most considerable effect on the lumbar extension moment and may help determine the lumbar spine risk factors at temporo-spatial coordination during squat lifting. Material and Methods: Twelve healthy men volunteered to perform slow and fast squat lifting of a box of varied mass (4 kg, 8 kg and 12 kg. The eight-channel electromyography was applied to detect the activities of abdominal (rectus abdominis and external oblique and lower back muscles (iliocostalis lumborum and multifidus. The lumbar extension moment was calculated using 3D linked segment model. Ground reaction forces and kinematic data were recorded using a Vicon system with 2 parallel Kistler force-plates. Results: Significant increases (both p-values 0.05 were detected between the lumbar angles related to the lower trunk muscles peak activities and lumbar angle related to the peak lumbar extension moment in most of the lifts. Conclusions: According to the findings, the inertial force of the lifted box is the most important factor that affects the lumbar extension moment during squat lifting. Moreover, critical lumbar angles are seemingly those ones in which the lifted box reaches the peak acceleration. Int J Occup Med Environ Health 2017;30(4:665–679

  9. Fe-catalyzed novel domino isomerization/cyclodehydration of substituted 2-[(indoline-3-ylidene)(methyl)]benzaldehyde derivatives: an efficient approach toward benzo[b]carbazole derivatives.

    Science.gov (United States)

    Paul, Kartick; Bera, Krishnendu; Jalal, Swapnadeep; Sarkar, Soumen; Jana, Umasish

    2014-04-18

    A new and efficient protocol to synthesize substituted benzo[b]carbazole derivatives has been demonstrated involving iron-catalyzed domino isomerization/cyclodehydration sequences from substituted 2-[(indoline-3-ylidene)(methyl)]benzaldehyde derivatives. The substrates could be easily made via Pd-catalyzed domino Heck-Suzuki coupling from 2-bromo-N-propargylanilide derivatives in high yields. Notably, the generality and efficiency of this two-stage domino strategy was further exemplified by the synthesis of a polycyclic benzofuran derivative.

  10. Siting a municipal solid waste disposal facility, part II: the effects of external criteria on the final decision.

    Science.gov (United States)

    Korucu, M Kemal; Karademir, Aykan

    2014-02-01

    The procedure of a multi-criteria decision analysis supported by the geographic information systems was applied to the site selection process of a planning municipal solid waste management practice based on twelve different scenarios. The scenarios included two different decision tree modes and two different weighting models for three different area requirements. The suitability rankings of the suitable sites obtained from the application of the decision procedure for the scenarios were assessed by a factorial experimental design concerning the effect of some external criteria on the final decision of the site selection process. The external criteria used in the factorial experimental design were defined as "Risk perception and approval of stakeholders" and "Visibility". The effects of the presence of these criteria in the decision trees were evaluated in detail. For a quantitative expression of the differentiations observed in the suitability rankings, the ranking data were subjected to ANOVA test after a normalization process. Then the results of these tests were evaluated by Tukey test to measure the effects of external criteria on the final decision. The results of Tukey tests indicated that the involvement of the external criteria into the decision trees produced statistically meaningful differentiations in the suitability rankings. Since the external criteria could cause considerable external costs during the operation of the disposal facilities, the presence of these criteria in the decision tree in addition to the other criteria related to environmental and legislative requisites could prevent subsequent external costs in the first place.

  11. Safety assessment in plant layout design using indexing approach: implementing inherent safety perspective. Part 2-Domino Hazard Index and case study.

    Science.gov (United States)

    Tugnoli, Alessandro; Khan, Faisal; Amyotte, Paul; Cozzani, Valerio

    2008-12-15

    The design of layout plans requires adequate assessment tools for the quantification of safety performance. The general focus of the present work is to introduce an inherent safety perspective at different points of the layout design process. In particular, index approaches for safety assessment and decision-making in the early stages of layout design are developed and discussed in this two-part contribution. Part 1 (accompanying paper) of the current work presents an integrated index approach for safety assessment of early plant layout. In the present paper (Part 2), an index for evaluation of the hazard related to the potential of domino effects is developed. The index considers the actual consequences of possible escalation scenarios and scores or ranks the subsequent accident propagation potential. The effects of inherent and passive protection measures are also assessed. The result is a rapid quantification of domino hazard potential that can provide substantial support for choices in the early stages of layout design. Additionally, a case study concerning selection among various layout options is presented and analyzed. The case study demonstrates the use and applicability of the indices developed in both parts of the current work and highlights the value of introducing inherent safety features early in layout design.

  12. Effect of physisorbed molecules and an external external fields on the metallic Shockley surface state of Cu(111): A density functional theory study

    Science.gov (United States)

    Berland, Kristian; Einstein, T. L.; Hyldgaard, Per

    2012-02-01

    To manipulate the Cu(111) partially-filled Shockley surface state, we study its response to an external fieldootnotetextKB, TLE, PH; arXiv 1109:6706 E and physisorbed PAHs and quinone molecules. We use density-functional theory calculations with periodic-boundary conditions. The van der Waals density functional version vdW-DF2 accounts for the molecular adsorption. The issue that the Kohn-Sham wave functions couple to both sides of the Cu slab is handled with a decoupling scheme based on a rotation in Hilbert space. A convergence study reveals that to obtain a proper Shockley surface state, 6 Cu layers is sufficient, while 15 is optimal. We use 6 layers for the response to the molecules and 15 to external field. We find that the surface state displays isotropic dispersion (up to order k^6), free-electron like until the Fermi wave vector but with a significant quartic component beyond. The shift in band minimum and effective mass depend linearly on E, with a smaller fractional change in the latter. Charge transfer occurs beyond the outermost copper atoms, and most of the screening is due to bulk electrons. We find that the molecular physisorption increases the band minimum, with the effect the of a quinone being much stronger than the corresponding PAH.

  13. 利用DOMINO建立WEB应用的研究与实现%How to Establish the Web Service By Using Domino

    Institute of Scientific and Technical Information of China (English)

    王军; 黄海茹

    2001-01-01

    文章详细介绍了Domino作为Web服务器的特点及Domino的Web结构,介绍了Domino的开发工具及Domino和数据库的连接。最后说明了Domino的Web服务器的设置方法。%This paper introduces the characteristic and structure of DominoWeb service.The it also introduces the tools to develop Domino and the ways to connect Domino to database.And finally the author describes how to set up the Domino server.

  14. Effects of cycle duration of an external electrostatic field on anammox biomass activity

    Science.gov (United States)

    Yin, Xin; Qiao, Sen; Zhou, Jiti

    2016-01-01

    In this study, the effects of different cycle durations of an external electrostatic field on an anammox biomass were investigated. The total application time per day was 12 h at 2 V/cm for different cycle durations (i.e., continuous application-resting time) of 3 h-3 h, 6 h-6 h, and 12 h-12 h. Compared with the control reactor, the nitrogen removal rates (NRRs) increased by 18.7%, 27.4% and 8.50% using an external electrostatic field application with a continuous application time of 3 h, 6 h and 12 h. Moreover, after the reactor was running smoothly for approximately 215 days under the optimal electrostatic field condition (mode 2, continuous application-rest time: 6 h-6 h), the total nitrogen (TN) removal rate reached a peak value of approximately 6468 g-N/m3/d, which was 44.7% higher than the control. The increase in 16S rRNA gene copy numbers, heme c content and enzyme activities were demonstrated to be the main reasons for enhancement of the NRR of the anammox process. Additionally, transmission electron microscope observations proved that a morphological change in the anammox biomass occurred under an electrostatic field application.

  15. ERP系统应用与Lotus Domino for AS/400的集成%ERP System Application and Integration of Lotus Domino for AS/400

    Institute of Scientific and Technical Information of China (English)

    曹玉华; 王晶洁

    2001-01-01

    IBM eServer AS/400以其功能强大的数据库系统DB2/400,逐渐成为ERP系统应用的核心.Lotus Domino for AS/400是以邮件为驱动的群件系统服务器,它为企业办公提供了安全方便的流程管理机制.通过分析Domino与DB2/400的集成技术,提出在Domino中实现ERP系统应用的可行方案.

  16. [Effect of External Applying Compound Tripterygium wilfordii Hook F. on Joint Pain of Rheumatoid Arthritis Patients].

    Science.gov (United States)

    Jiao, Juan; Tang, Xiao-po; Yuan, Jing; Liu, Xu; Liu, Hui; Zhang, Chun-yan; Wang, Li-ying; Jiang, Quan

    2016-01-01

    To observe the effectiveness and safety of external applying Compound Tripterygium wilfordii Hook F. (TwHF) in relieving joint pain in rheumatoid arthritis (RA) patients. In this double-blinded, randomized multicenter trial, a total of 174 moderately active RA patients were enrolled and randomly assigned to the treatment group (treated with Compound TwHF, 87 cases) and the placebo control group (87 cases). Compound TwHF or placebo was externally applied in painful joints, 20 g each time, once per day for 8 weeks. Self-reported joint pain relief was taken as a primary effective indicator. Visual analogue scale for pain (VAS), disease activity score of 28 joints (DAS28), VAS for general health (GH) were evaluated before treatment, at week 4 and after treatment. Erythrocyte sedimentation rate (ESR) and hypersensitive C reactive protein (hs-CRP) were tested before and after treatment. Menstrual changes in females were observed during treatment. Skin irritation occurred during the recording process was assessed using skin irritation strength. Intention to treat (ITT) was statistically analyzed. The joint pain relief rate in the treatment group was 90.8% (79/87 cases), higher than that in the placebo control group (69.0%, 60/87 cases; P = 0.001). VAS pain score, DAS28, VAS for GH score were significantly improved in the two groups at week 4 of treatment and after treatment, as compared with before treatment (P 0.05). Eight adverse events occurred in the treatment group (5 skin allergy, 1 intolerance of medical odor, and 2 mild liver injury), while 3 adverse events occurred in the placebo control group (2 skin allergy, 1 mild liver injury). There was no statistical difference in adverse event between the two groups (P > 0.05). No menstrual change occurred in the treatment group. External applying Compound TwHF was an effective and safe way to relieve-joint pain of RA patients, which could be taken as an adjuvant therapy.

  17. Domino Cyclization of 1,n-Enynes (n = 7, 8, 9) Giving Derivatives of Pyrane, Chromene, Fluorene, Phenanthrene and Dibenzo[7]annulene by Ruthenium Complexes.

    Science.gov (United States)

    Ma, Hao-Wei; Chen, Pei-Min; Lo, Ji-Xian; Lin, Ying-Chih; Huang, Shou-Ling; Chen, Chi-Ren; Chia, Pi-Yeh

    2016-06-03

    Cyclization of the ether enyne 1 catalyzed by [Ru]NCCH3(+) ([Ru] = Cp(PPh3)2Ru) in CHCl3 generates a diastereomeric mixture of the substituted tetrahydropyran 11. Presumably, formation of an allenylidene complex is followed by a cyclization by nucleophilic addition of the olefinic group to Cγ of the ligand giving a boat-like six-membered ring. The diastereoselectivity is controlled by the 1,3-diaxial interaction. The vinylidene complex 7, a precursor of 11, is obtained from 1 and [Ru]Cl. In a mixture of MeOH/CHCl3, the domino cyclization of 1 further affords 14a, a chromene product catalytically. The second cyclization proceeds via nucleophilic addition of the resulting olefinic unit to Cα of 7. But the ether enyne 3 with a cyclopentyl ring on the olefinic unit undergoes only single cyclization due to steric effect. The propargyl alcohol and the two terminal methyl groups on the olefinic unit shape the cyclization. Thus, similar all-carbon 1,n-enynes (n = 7, 8, 9) 4-6 each with an aromatic linker undergo direct domino cyclization catalyzed by [Ru]NCCH3(+), to give derivatives of tricyclic fluorene, phenanthrene and dibenzo[7]annulene, respectively, with no intermediate observed.

  18. The effect of external heat transfer on thermal explosion in a spherical vessel with natural convection.

    Science.gov (United States)

    Campbell, A N

    2015-07-14

    When any exothermic reaction proceeds in an unstirred vessel, natural convection may develop. This flow can significantly alter the heat transfer from the reacting fluid to the environment and hence alter the balance between heat generation and heat loss, which determines whether or not the system will explode. Previous studies of the effects of natural convection on thermal explosion have considered reactors where the temperature of the wall of the reactor is held constant. This implies that there is infinitely fast heat transfer between the wall of the vessel and the surrounding environment. In reality, there will be heat transfer resistances associated with conduction through the wall of the reactor and from the wall to the environment. The existence of these additional heat transfer resistances may alter the rate of heat transfer from the hot region of the reactor to the environment and hence the stability of the reaction. This work presents an initial numerical study of thermal explosion in a spherical reactor under the influence of natural convection and external heat transfer, which neglects the effects of consumption of reactant. Simulations were performed to examine the changing behaviour of the system as the intensity of convection and the importance of external heat transfer were varied. It was shown that the temporal development of the maximum temperature in the reactor was qualitatively similar as the Rayleigh and Biot numbers were varied. Importantly, the maximum temperature in a stable system was shown to vary with Biot number. This has important consequences for the definitions used for thermal explosion in systems with significant reactant consumption. Additionally, regions of parameter space where explosions occurred were identified. It was shown that reducing the Biot number increases the likelihood of explosion and reduces the stabilising effect of natural convection. Finally, the results of the simulations were shown to compare favourably with

  19. Rapidly progressive atherosclerosis after domino liver transplantation from a teenage donor with homozygous familial hypercholesterolemia.

    Science.gov (United States)

    Golbus, Jessica R; Farhat, Linda; Fontana, Robert J; Rubenfire, Melvyn

    2017-07-22

    Familial hypercholesterolemia (FH) is an autosomal dominant disorder characterized by impaired clearance of low-density lipoprotein cholesterol. Given limitations in pharmacologic therapy and the significant morbidity and mortality associated with this disease, liver transplantation may be offered to select homozygous FH patients in childhood in an effort to slow progression of atherosclerotic cardiovascular disease. In rare cases, domino liver transplantation can be performed, transplanting the livers of patients with various metabolic disorders into elderly recipients whose projected survival precludes prolonged waiting on the transplant list. Herein, we report a case of domino liver transplantation using the liver of a 14-year-old boy with homozygous FH into a 65-year-old man with primary sclerosing cholangitis and cirrhosis who developed rapidly progressive atherosclerotic cardiovascular disease involving the arteries of his proximal bilateral lower extremities, carotid arteries and superior mesenteric artery. Copyright © 2017 National Lipid Association. Published by Elsevier Inc. All rights reserved.

  20. Four- and Sixfold Tandem-Domino Reactions Leading to Dimeric Tetrasubstituted Alkenes Suitable as Molecular Switches.

    Science.gov (United States)

    Tietze, Lutz F; Waldecker, Bernd; Ganapathy, Dhandapani; Eichhorst, Christoph; Lenzer, Thomas; Oum, Kawon; Reichmann, Sven O; Stalke, Dietmar

    2015-08-24

    A highly efficient palladium-catalyzed fourfold tandem-domino reaction consisting of two carbopalladation and two C-H-activation steps was developed for the synthesis of two types of tetrasubstituted alkenes 3 and 6 with intrinsic helical chirality starting from substrates 1 and 4, respectively. A sixfold tandem-domino reaction was also developed by including a Sonogashira reaction. 20 compounds with different substitution patterns were prepared with yields of up to 97 %. Structure elucidation by X-ray crystallography confirmed helical chirality of the two alkene moieties. Photophysical investigations of some of the compounds showed pronounced switching properties through light-controlled changes of their stereochemical configuration. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. THE EFFECT OF EMOTIONAL INTELLIGENCE TRAINING ON BEHAVIOR PROBLEMS OF BOYS WITH EXTERNALIZED BEHAVIOR DISORDER IN ELEMENTARY SCHOOLS

    OpenAIRE

    Kosar Moghaddam POUR; ADIBSERESHKI, Narges; Masome POURMOHAMADREZA-TAJRISHI; Samaneh HOSSEINZADEH

    2015-01-01

    The purpose of this study is to investigate the effect of emotional intelligence on the behavior problems of boys with Externalized behavior disorder in Primary Schools. Method: This quasi-experimental study was conducted along with a pre-test, post-test, with a control group and a follow-up test. For sampling, 40 students identified with Externalized behavioral problems through the Teacher Report Form (TRF) and the Child Behavior Checklist (CBCL) were chosen and randomly divided into two ...

  2. The Effects of Child Abuse and Exposure to Domestic Violence on Adolescent Internalizing and Externalizing Behavior Problems

    OpenAIRE

    Moylan, Carrie A.; Herrenkohl, Todd I.; Sousa, Cindy; Tajima, Emiko A.; Herrenkohl, Roy C.; Russo, M. Jean

    2010-01-01

    This study examines the effects of child abuse and domestic violence exposure in childhood on adolescent internalizing and externalizing behaviors. Data for this analysis are from the Lehigh Longitudinal Study, a prospective study of 457 youth addressing outcomes of family violence and resilience in individuals and families. Results show that child abuse, domestic violence, and both in combination (i.e., dual exposure) increase a child’s risk for internalizing and externalizing outcomes in ad...

  3. Domino shuffling on Novak half-hexagons and Aztec half-diamonds

    CERN Document Server

    Nordenstam, Eric

    2011-01-01

    We explore the connections between the well-studied Aztec Diamond graphs and a new family of graphs called the Half-Hexagons, discovered by Jonathan Novak. In particular, both families of graphs have very simple domino shuffling algorithms, which turn out to be intimately related. This connection allows us to prove an "arctic parabola" theorem for the Half-Hexagons as a corollary of the Arctic Circle theorem for the Aztec Diamond.

  4. Asymmetric Synthesis of Fully Substituted Cyclopentane-Oxindoles through an Organocatalytic Triple Michael Domino Reaction

    Science.gov (United States)

    Zou, Liang-Hua; Philipps, Arne R; Raabe, Gerhard; Enders, Dieter

    2015-01-01

    An efficient, highly stereoselective asymmetric synthesis of fully functionalized cyclopentanes bearing an oxindole moiety and several other functional groups in one pot has been developed. Key step is an organocatalytic triple Michael domino reaction forming three C–C bonds and six stereocenters, including a quaternary one. Starting from equimolar amounts of simple substrates, a high molecular complexity can be reached after a Wittig olefination in one pot. The new protocol can easily be scaled up to gram amounts. PMID:25470781

  5. Efficient Domino Hydroformylation/Benzoin Condensation: Highly Selective Synthesis of α-Hydroxy Ketones.

    Science.gov (United States)

    Dong, Kaiwu; Sang, Rui; Soule, Jean-Francois; Bruneau, Christian; Franke, Robert; Jackstell, Ralf; Beller, Matthias

    2015-12-07

    An improved domino hydroformylation/benzoin condensation to give α-hydroxy ketones has been developed. Easily available olefins are smoothly converted into the corresponding α-hydroxy ketones in high yields with excellent regioselectivities. Key to success is the use of a specific catalytic system consisting of a rhodium/phosphine complex and the CO2 adduct of an N-heterocyclic carbene. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Post-Ugi gold-catalyzed diastereoselective domino cyclization for the synthesis of diversely substituted spiroindolines

    Directory of Open Access Journals (Sweden)

    Amit Kumar

    2013-10-01

    Full Text Available An Ugi four-component reaction of propargylamine with 3-formylindole and various acids and isonitriles produces adducts which are subjected to a cationic gold-catalyzed diastereoselective domino cyclization to furnish diversely substituted spiroindolines. All the reactions run via an exo-dig attack in the hydroarylation step followed by an intramolecular diastereoselective trapping of the imminium ion. The whole sequence is atom economic and the application of a multicomponent reaction assures diversity.

  7. Domino hydroformylation/aldol condensation/hydrogenation catalysis: highly selective synthesis of ketones from olefins.

    Science.gov (United States)

    Fang, Xianjie; Jackstell, Ralf; Börner, Armin; Beller, Matthias

    2014-11-24

    A general and highly chemo- and regioselective synthesis of ketones from olefins by domino hydroformylation/aldol condensation/hydrogenation reaction has been developed. A variety of olefins are efficiently converted into various ketones in good to excellent yields and regioselectivities in the presence of a specific rhodium phosphine/base-acid catalyst system. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Mass transport model of ions within biofilms under the effect of external field

    Institute of Scientific and Technical Information of China (English)

    WANG Jun; TANG Xue-xi

    2006-01-01

    A mass transport model was developed to predict the transport rate of ions within biofilms, which was experimentally verified using the fluxes ofNH4+ and Ca2+ through the heterotrophic biofilms with the thickness varying from 230 to 1430 μm under the effect of external field in the range of-20 V/m to 60 V/m. It is found that the result predicted by the model is in agreement with the experimentally obtained one, with the error less than 5 percent for the thin biofilms. The error increases with the increase of the biofilm thickness. The transport rate of ions caused by electric migration is affected by the charges, field strength, and biofilm thickness and so on.

  9. Effect of an External Oriented Magnetic Field on Entropy Generation in Natural Convection

    Directory of Open Access Journals (Sweden)

    Atef El Jery

    2010-05-01

    Full Text Available The influence of an external oriented magnetic field on entropy generation in natural convection for air and liquid gallium is numerically studied in steady-unsteady states by solving the mass, the momentum and the energy conservation equations. Entropy generation depends on five parameters which are: the Prandtl number, the irreversibility coefficients, the inclination angle of the magnetic field, the thermal Grashof and the Hartmann numbers. Effects of these parameters on total and local irreversibilities as well as on heat transfer and fluid flow are studied. It was found that the magnetic field tends to decrease the convection currents, the heat transfer and entropy generation inside the enclosure. Influence of inclination angle of the magnetic field on local irreversibility is then studied.

  10. The effect of external magnetic field on plasma acceleration in electromagnetic railgun channel

    Science.gov (United States)

    Bobashev, S. V.; Zhukov, B. G.; Kurakin, R. O.; Ponyaev, S. A.; Reznikov, B. I.

    2016-03-01

    We have studied the effect of an external magnetic field on the dynamics of a free plasma piston (PP) accelerated without solid striker armature in an electromagnetic railgun channel filled with various gases (argon or helium). It is established that, as the applied magnetic field grows, the velocity of a shock wave generated by PP in the channel increases. The experimental results are compared to a theoretical model that takes into account the gas pressure force behind the shock wave and the drag force that arises when erosion mass entering the channel is partly entrained by the accelerated plasma. The results of model calculations are in satisfactory agreement with experimental data. The discrepancy somewhat increases with the applied field, but the maximum deviation still does not exceed 20%.

  11. Multimodality Imaging of Cardiac Transthyretin Amyloidosis 16 Years After a Domino Liver Transplantation.

    Science.gov (United States)

    Bechiri, M Y; Eliahou, L; Rouzet, F; Fouret, P-J; Antonini, T; Samuel, D; Adam, R; Adams, D; Slama, M S; Algalarrondo, V

    2016-07-01

    We report the case of a 62-year-old man hospitalized in May 2015 for symptomatic heart failure. His medical history included two liver transplantations. The first liver transplantation was performed in 1999 for a mixed alcoholic and hepatitis C-related cirrhosis and the patient received the liver of another patient with Val30Met transthyretin amyloidosis using the domino technique. In 2008, he complained of neuropathic pains and an iatrogenic-acquired transthyretin amyloidosis was diagnosed. On cardiac evaluation, amyloidosis was suspected. In March 2010, a second liver transplantation was performed with a deceased donor without complication. In May 2015, a first episode of symptomatic heart failure occurred and cardiac amyloidosis was investigated by a multimodality evaluation. Electrocardiogram, cardiac biomarkers, echocardiography, and cardiac MRI were in favor of the diagnosis of amyloidosis, whereas (99m) Tc-dicarboxypropane diphosphonate scintigraphy was not. Endomyocardial biopsy finally confirmed the positive diagnosis of iatrogenic-acquired cardiac amyloidosis. This case is, to the best of our knowledge, the first to report biopsy-proven cardiac amyloidosis induced by domino liver transplantation and progressing heart failure in spite of retransplantation. The diagnostic modalities are discussed. This case should alert physicians to the cardiac risk in domino liver transplanted patients. © Copyright 2016 The American Society of Transplantation and the American Society of Transplant Surgeons.

  12. The Effect of External Factors on Consumption Electricity Loads Forecasting using Fuzzy Takagi-Sugeno Kang

    Directory of Open Access Journals (Sweden)

    Gayatri Dwi Santika

    2017-03-01

    Full Text Available This study applied Fuzzy Inference System Sugeno to forecast electrical load by considering the external factors. To see the accuracy of forecasting using Fuzzy Inference System Sugeno, then a comparison between the forecasting results of Fuzzy Inference System Sugeno using historical data with Fuzzy Inference System Sugeno using external factors was done. By using external factors method, resulted the smallest RMSE of 0762 and using historical data obtained error (RMSE of 1028. The results of the study came to the conclusion that Fuzzy Inference System Sugeno method using external factors to forecast the consumption of electrical load gives a better result than Fuzzy Inference System Sugeno using only historical data.

  13. Effectiveness of external respiratory surrogates for in vivo liver motion estimation

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Kai-Hsiang; Ho, Ming-Chih; Yeh, Chi-Chuan; Chen, Yu-Chien; Lian, Feng-Li; Lin, Win-Li; Yen, Jia-Yush; Chen, Yung-Yaw [Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan (China); Department of Surgery, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei 10041, Taiwan (China); Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan (China); Department of Electrical Engineering, National Taiwan University, Taipei 10617, Taiwan (China); Institute of Biomedical Engineering, National Taiwan University, Taipei 10041, Taiwan (China); Department of Mechanical Engineering, National Taiwan University, Taipei 10617, Taiwan (China); Department of Electrical Engineering and Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei 10617, Taiwan (China)

    2012-08-15

    Purpose: Due to low frame rate of MRI and high radiation damage from fluoroscopy and CT, liver motion estimation using external respiratory surrogate signals seems to be a better approach to track liver motion in real-time for liver tumor treatments in radiotherapy and thermotherapy. This work proposes a liver motion estimation method based on external respiratory surrogate signals. Animal experiments are also conducted to investigate related issues, such as the sensor arrangement, multisensor fusion, and the effective time period. Methods: Liver motion and abdominal motion are both induced by respiration and are proved to be highly correlated. Contrary to the difficult direct measurement of the liver motion, the abdominal motion can be easily accessed. Based on this idea, our study is split into the model-fitting stage and the motion estimation stage. In the first stage, the correlation between the surrogates and the liver motion is studied and established via linear regression method. In the second stage, the liver motion is estimated by the surrogate signals with the correlation model. Animal experiments on cases of single surrogate signal, multisurrogate signals, and long-term surrogate signals are conducted and discussed to verify the practical use of this approach. Results: The results show that the best single sensor location is at the middle of the upper abdomen, while multisurrogate models are generally better than the single ones. The estimation error is reduced from 0.6 mm for the single surrogate models to 0.4 mm for the multisurrogate models. The long-term validity of the estimation models is quite satisfactory within the period of 10 min with the estimation error less than 1.4 mm. Conclusions: External respiratory surrogate signals from the abdomen motion produces good performance for liver motion estimation in real-time. Multisurrogate signals enhance estimation accuracy, and the estimation model can maintain its accuracy for at least 10 min. This

  14. Effects of external gamma radiation on femoral artery reimplantation in rats: morphometrical analyzes

    Directory of Open Access Journals (Sweden)

    Costa Regina de Faria Bittencourt da

    2003-01-01

    Full Text Available PURPOSE: To investigate the effects of external gamma radiation on rat femoral artery reimplant. METHODS: Sixty-two male Wistar rats were distributed in two groups I (Control and II (Irradiated, both formed by three observation subgroups: 2 (10 animals, 7 (11 and 21(10 postoperative days (PO. The right femoral artery of each animal was split up and reimplanted (end-to-end anastomosis, through microsurgery technique. In the first PO day group II animals were irradiated with a single dose of 15Gy, external source. The histological analysis, qualitative and descriptive analysis, was accomplished through hematoxylin and eosin (HE, Verhoeff and Masson trichromium methodology. Morphometric analysis was realized in the same slides used to histological analysis stained by HE. Computer software was used to quantify morphological alterations of the vascular wall, by processing captured images from a microscope. It was analyzed the intimal layer (intimal hyperplasia and endothelium cells formation and the nuclei percentage of smooth muscular cell in the medium layer and in the intima hyperplasia. The data were treated applying the statistical tests: Fisher's exact, Chi-square, Mann-Whitney, Kruskal-Wallis and analysis of variance (p < .05. RESULTS: The patency graft was observed by microscope distal to the autograft in 93.5% (29/31. It was observed that the gamma-radiation reduced the degree of covering of the vascular wall for the neo-formed endothelium. The nuclei percentage of smooth muscular cells, in the media, was smaller compared to control animals, although it was no significant for the studied sample size. The irradiated group showed a significant lower luminal stenosis and the intimal hyperplasia occurrence. In this group the percentage of smooth muscular cells proliferation, in the media, were significantly lower for 7 and 21 days of observation. CONCLUSION: The external single dose of 15 Gy gamma-radiation delivered at first postoperative day

  15. Preventing adolescents’ externalizing and internalizing symptoms: Effects of the Penn Resiliency Program

    Directory of Open Access Journals (Sweden)

    J. J. Cutuli

    2013-11-01

    Full Text Available This study reports secondary outcome analyses from a past study of the Penn Resiliency Program (PRP, a cognitive-behavioral depression prevention program for middle-school aged children. Middle school students (N = 697 were randomly assigned to PRP, PEP (an alternate intervention, or control conditions. Gillham et al., (2007 reported analyses examining PRP’s effects on average and clinical levels of depression symptoms. We examine PRP’s effects on parent-, teacher-, and self-reports of adolescents’ externalizing and broader internalizing (depression/anxiety, somatic complaints, and social withdrawal symptoms over three years of follow-up. Relative to no intervention control, PRP reduced parent-reports of adolescents’ internalizing symptoms beginning at the first assessment after the intervention and persisting for most of the follow-up assessments. PRP also reduced parent-reported conduct problems relative to no-intervention. There was no evidence that the PRP program produced an effect on teacher- or self-report of adolescents’ symptoms. Overall, PRP did not reduce symptoms relative to the alternate intervention, although there is a suggestion of a delayed effect for conduct problems. These findings are discussed with attention to developmental trajectories and the importance of interventions that address common risk factors for diverse forms of negative outcomes.

  16. DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease – a multicentre RCT

    Directory of Open Access Journals (Sweden)

    Lindesay James

    2009-07-01

    Full Text Available Abstract Background Alzheimer's disease (AD is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glutamate antagonist memantine has been widely prescribed, often in the later stages of AD. Memantine is licensed for moderate to severe dementia in AD but is not recommended by the England and Wales National Institute for Health and Clinical Excellence. However, there is little evidence to guide clinicians as to what to prescribe as AD advances; in particular, what to do as the condition progresses from moderate to severe. Options include continuing cholinesterase inhibitors irrespective of decline, adding memantine to cholinesterase inhibitors, or prescribing memantine instead of cholinesterase inhibitors. The aim of this trial is to establish the most effective drug option for people with AD who are progressing from moderate to severe dementia despite treatment with donepezil. Method DOMINO-AD is a pragmatic, 15 centre, double-blind, randomized, placebo controlled trial. Patients with AD, currently living at home, receiving donepezil 10 mg daily, and with Standardized Mini-Mental State Examination (SMMSE scores between 5 and 13 are being recruited. Each is randomized to one of four treatment options: continuation of donepezil with memantine placebo added; switch to memantine with donepezil placebo added; donepezil and memantine together; or donepezil placebo with memantine placebo. 800 participants are being recruited and treatment continues for one year. Primary outcome measures are cognition (SMMSE and activities of daily living (Bristol Activities of Daily Living Scale. Secondary outcomes are non-cognitive dementia symptoms (Neuropsychiatric Inventory, health related quality of life (EQ-5D and DEMQOL-proxy, carer burden (General Health Questionnaire-12, cost effectiveness (using Client Service Receipt Inventory and

  17. Sling-based Exercise for External Rotator Muscles: Effects on Shoulder Profile in Young Recreational Tennis Players

    Science.gov (United States)

    Goulet, Charles; Rogowski, Isabelle

    2016-12-19

    Context: Tennis playing generates specific adaptations, particularly at the dominant shoulder. It remains to be established whether shoulder strength balance can be restored by sling-based training for adolescent recreational tennis players. Objective: We added a sling-based exercise for shoulder external rotators to investigate its effects on external rotator muscle strength, on internal rotator muscle strength, on glenohumeral range of motion and on tennis serve performance. Design: Test-retest design. Setting: Tennis training sports facilities. Participants: Twelve adolescent male players volunteered to participate in this study (age: 13.3 ± 0.5 years; height: 1.64 ± 0.07 cm, mass: 51.7 ± 5.8 kg, International Tennis Number: 8). Intervention: The procedure spanned 10 weeks. For the first five weeks, players performed their regular training (RT) twice a week. For the last five weeks, a sling-based exercise (SE) for strengthening the shoulder external rotator muscles was added to their regular training. Main Outcome Measures: Maximal isometric strength of shoulder external and internal rotator muscles and glenohumeral range of motion in external and internal rotation were assessed in both shoulders. Serve performance was also evaluated by accuracy and post-impact ball velocity, using a radar gun. Results: No change was found in any measurement after the RT period. Significant increases in external (~+5%; pmuscle strength and in external/internal strength ratio (~+4%; pshoulder external rotator muscles appears effective in restoring strength balance at the dominant shoulder, and may prevent adolescent tennis players from sustaining degenerative shoulder problems which could later impair their performance of daily and work-related tasks.

  18. Effects of differently hardened brass foil laminate on the electromechanical property of externally laminated CC tapes

    Energy Technology Data Exchange (ETDEWEB)

    Bautista, Zhierwinjay; Shin, Hyung Seop [Dept. of Mechanical Design Engineering, Andong National University, Andong (Korea, Republic of); Mean, Byoung Jean; Lee, Jae Hun [SuNAM Co Ltd., Anseong (Korea, Republic of)

    2016-12-15

    The mechanical properties of REBCO coated conductor (CC) wires under uniaxial tension are largely determined by the thick component layers in the architecture, namely, the substrate and the stabilizer or even the reinforcement layer. Depending on device applications of the CC tapes, it is necessary to reinforce thin metallic foils externally to one-side or both sides of the CC tapes. Due to the external reinforcement of brass foils, it was found that this could increase the reversible strain limit from the Cu-stabilized CC tapes. In this study, the effects of differently hardened brass foil laminate on the electromechanical property of CC tapes were investigated under uniaxial tension loading. The tensile strain dependence of the critical current (I{sub c}) was measured at 77 K and self-field. Depending on whether the I{sub c} of CC tapes were measured during loading or after unloading, a reversible strain (or stress) limit could be determined, respectively. The both-sides of the Cu-stabilized CC tapes were laminated with brass foils with different hardness, namely 1/4H, 1H and EH. From the obtained results, it showed that the yield strength of the brass laminated CC tapes with EH brass foil laminate was comparable to the one of the Cu-stabilized CC tape due to its large yield strength even though its large volume fraction. It was found that the brass foil with different hardness was mainly sensitive on the stress dependence of I{sub c}, but not on the strain sensitivity due to the residual strain induced in the laminated CC tapes during unloading.

  19. The Association of Birth Complications and Externalizing Behavior in Early Adolescents: Direct and Mediating Effects

    Science.gov (United States)

    Liu, Jianghong; Raine, Adrian; Wuerker, Anne; Venables, Peter H.; Mednick, Sarnoff

    2009-01-01

    Prior studies have shown that birth complications interact with psychosocial risk factors in predisposing to increased externalizing behavior in childhood and criminal behavior in adulthood. However, little is known about the direct relationship between birth complications and externalizing behavior. Furthermore, the mechanism by which the birth…

  20. Effects of early maternal distress and parenting on the development of children's self-regulation and externalizing behavior.

    Science.gov (United States)

    Choe, Daniel Ewon; Olson, Sheryl L; Sameroff, Arnold J

    2013-05-01

    Emotional distress experienced by mothers increases young children's risk of externalizing problems through suboptimal parenting and child self-regulation. An integrative structural equation model tested hypotheses that mothers' parenting (i.e., low levels of inductive discipline and maternal warmth) would mediate adverse effects of early maternal distress on child effortful control, which in turn would mediate effects of maternal parenting on child externalizing behavior. This longitudinal study spanning ages 3, 6, and 10 included 241 children, mothers, and a subset of teachers. The hypothesized model was partially supported. Elevated maternal distress was associated with less inductive discipline and maternal warmth, which in turn were associated with less effortful control at age 3 but not at age 6. Inductive discipline and maternal warmth mediated adverse effects of maternal distress on children's effortful control. Less effortful control at ages 3 and 6 predicted smaller relative decreases in externalizing behavior at 6 and 10, respectively. Effortful control mediated effects of inductive discipline, but not maternal warmth, on externalizing behavior. Findings suggest elevated maternal distress increases children's risk of externalizing problems by compromising early parenting and child self-regulation.

  1. Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers

    NARCIS (Netherlands)

    Absalom, A. R.; Lee, M.; Menon, D. K.; Sharar, S. R.; De Smet, T.; Halliday, J.; Ogden, M.; Corlett, P.; Honey, G. D.; Fletcher, P. C.

    2007-01-01

    Background. Healthy volunteers received low-dose target-controlled infusions (TCI) of ketamine controlled by the Domino model while cognitive function tests and functional neuroimaging were performed. The aim of the current study was to assess the predictive performance of the Domino model during th

  2. The Lifetime Value of a Loyal Customer: What Can a Child Care Director Learn from Domino's Pizza and a Cadillac Dealer in Dallas?

    Science.gov (United States)

    Copeland, Margaret Leitch; Gimilaro, Susan

    2010-01-01

    In "The Service Profit Chain," Harvard Business School professors James Heskett, Earl Sasser, and Leonard Schlesinger (1997) offer two anecdotes--from Domino's Pizza and a Dallas Cadillac dealership--that illuminate the concept of valuing a lifetime customer. Experts estimate that the lifetime value of a loyal Domino's Pizza customer is $4,000 and…

  3. The Lifetime Value of a Loyal Customer: What Can a Child Care Director Learn from Domino's Pizza and a Cadillac Dealer in Dallas?

    Science.gov (United States)

    Copeland, Margaret Leitch; Gimilaro, Susan

    2010-01-01

    In "The Service Profit Chain," Harvard Business School professors James Heskett, Earl Sasser, and Leonard Schlesinger (1997) offer two anecdotes--from Domino's Pizza and a Dallas Cadillac dealership--that illuminate the concept of valuing a lifetime customer. Experts estimate that the lifetime value of a loyal Domino's Pizza customer is $4,000 and…

  4. Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers

    NARCIS (Netherlands)

    Absalom, A. R.; Lee, M.; Menon, D. K.; Sharar, S. R.; De Smet, T.; Halliday, J.; Ogden, M.; Corlett, P.; Honey, G. D.; Fletcher, P. C.

    2007-01-01

    Background. Healthy volunteers received low-dose target-controlled infusions (TCI) of ketamine controlled by the Domino model while cognitive function tests and functional neuroimaging were performed. The aim of the current study was to assess the predictive performance of the Domino model during th

  5. Effects of the number of inducer blades on the anti-cavitation characteristics and external performance of a centrifugal pump

    Energy Technology Data Exchange (ETDEWEB)

    Guo, XiaoMei; Shi, GaoPing [Zhejiang University of Water Resources and Electric Power, Hangzhou (China); Zhu, ZuChao; Cui, BaoLing [Zhejiang Sci-Tech University, Hangzhou (China)

    2016-07-15

    Installing an inducer upstream of the main impeller is an effective approach for improving the anti-cavitation performance of a high speed centrifugal pump. For a high-speed centrifugal pump with an inducer, the number of inducer blades can affect its internal flow and external performance. We studied the manner in which the number of inducer blades can affect the anti-cavitation characteristics and external performance of a centrifugal pump. We first use the Rayleigh-Plesset equation and the mixture model to simulate the vapor liquid flow in a centrifugal pump with an inducer, and then predict its external performance. Finally, we tested the external performance of a centrifugal pump with 2-, 3- and 4-bladed inducers, respectively. The results show that the simulations of external performance in a centrifugal pump are in accordance with our experiments. Based on this, we obtained vapor volume fraction distributions for the inducer, the impeller, and in the corresponding whole flow parts. We discovered that the vapor volume fraction of a centrifugal pump with a 3- bladed inducer is less than that of a centrifugal pump with 2- or 4-bladed inducers, which means that a centrifugal pump with a 3-bladed inducer has a better external and anti-cavitation performance.

  6. External electric field effect on exciton binding energy in InGaAsP/InP cylindrical quantum wires

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Hailong, E-mail: hlwang@mail.qfnu.edu.cn [College of Physics and Engineering, Qufu Normal University, Qufu 273165 (China); Wang, Wenjuan [College of Physics and Engineering, Qufu Normal University, Qufu 273165 (China); Gong, Qian; Wang, Shumin [State Key Laboratory of Functional Materials for Informatics, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050 (China)

    2016-12-15

    Exciton binding energies in InGaAsP/InP cylindrical quantum wires are calculated through variational method under the framework of effective-mass envelope-function approximation. It is shown that the variation of exciton binding energy is highly dependent on radius of the wire, material composition and external electric field. Exciton binding energy is a non-monotonic function of wire radius. It increases until it reaches a maximum, and then decreases as the wire radius decreases. With the increase of In composition, the wire radius need increase to reach the maximum value of exciton binding energy. It is also found that the external electric field has little effect on exciton binding energy. However, the excitonic effect will be destroyed when external electric field is large enough. In addition, the Stark shift of exciton binding energy is also calculated.

  7. The effects of the integration of external and internal communication features in digital magazines on consumers' magazine attitude

    NARCIS (Netherlands)

    Rauwers, F.; Voorveld, H.A.M.; Neijens, P.C.

    2016-01-01

    This study investigates the effects of external and internal communication features on consumers' digital magazine attitude, and the processes (i.e., perceived interactivity and social presence) underlying these effects. Both feature types enable communication between two or more people. Though, in

  8. Antisocial Peer Affiliation and Externalizing Disorders in the Transition from Adolescence to Young Adulthood: Selection versus Socialization Effects

    Science.gov (United States)

    Samek, Diana R.; Goodman, Rebecca J.; Erath, Stephen A.; McGue, Matt; Iacono, William G.

    2016-01-01

    Prior research has demonstrated both socialization and selection effects for the relationship between antisocial peer affiliation and externalizing problems in adolescence. Less research has evaluated such effects postadolescence. In this study, a cross-lagged panel analysis was used to evaluate the extent of "socialization" (i.e., the…

  9. Effects of a compression garment on shoulder external rotation force outputs during isotonic contractions.

    Science.gov (United States)

    Tsuruike, Masaaki; Ellenbecker, Todd S

    2013-02-01

    The use of compression garments (CGs) has been advocated for performance enhancement and recovery in athletes. The effect of a CG on humeral rotation motor control has not been previously tested. The purpose of this study was to examine the isotonic contraction of external rotation (ER) of the glenohumeral joint at different force outputs to determine the effect of wearing a long sleeve CG on muscular performance. Twelve male college tennis players and 12 male college soccer players were tested for ER of the dominant shoulder during both concentric and eccentric isotonic contractions. The subjects performed 5 consecutive repetitions of both concentric and eccentric ER at 20-30% and 40-50% of maximum voluntary isometric contraction (MVIC) intensities. All subjects were tested with and without CG as well as with and without ongoing visual feedback information (OVFI). The order of CG wearing and the presence of OVFI were randomly assigned across all subjects. The results indicated a significant 3-way interaction between CG wearing and OVFI across 2 loads. Specifically, significantly different mean value of the completion time was found between OVFI and no-OVFI without CG wearing at 40-50% of MVIC, whereas no difference in the completion time was found with and without OVFI with CG wearing. Taken together, with CG wearing, athletes may have ER at 40-50% of MVIC more readily maintained by peripheral feedback without visuomotor control imposed on force outputs as compared without CG wearing.

  10. Butterfly effect and holographic mutual information under external field and spatial noncommutativity

    Science.gov (United States)

    Huang, Wung-Hong; Du, Yi-Hsien

    2017-02-01

    We apply the transformation of mixing azimuthal and internal coordinate or mixing time and internal coordinate to a stack of N black M-branes to find the Melvin spacetime of a stack of N black D-branes with magnetic or electric flux in string theory, after the Kaluza-Klein reduction. We slightly extend previous formulas to investigate the external magnetic and electric effects on the butterfly effect and holographic mutual information. It shows that the Melvin fields do not modify the scrambling time and will enhance the mutual information. In addition, we also T-dualize and twist a stack of N black D-branes to find a Melvin Universe supported by the flux of the NSNS b-field, which describes a non-comutative spacetime. It also shows that the spatial noncommutativity does not modify the scrambling time and will enhance the mutual information. We also study the corrected mutual information in the backreaction geometry due to the shock wave in our three model spacetimes.

  11. Butterfly Effect and Holographic Mutual Information under External Field and Spatial Noncommutativity

    CERN Document Server

    Huang, Wung-Hong

    2016-01-01

    We apply the transformation of mixing azimuthal and internal coordinate or mixing time and internal coordinate to a stack of N black M-branes to find the Melvin spacetime of a stack of N black D-branes with magnetic or electric flux in string theory, after the Kaluza-Klein reduction. We slightly extend previous formulas to investigate the external magnetic and electric effects on the butterfly effect and holographic mutual information. It shows that the Melvin fields do not modify the scrambling time and will enhance the mutual information. In addition, we also T-dualize and twist a stack of N black D-branes to find a Melvin Universe supported by the flux of the NSNS b-field, which describes a non-comutative spacetime. It also shows that the spatial noncommutativity does not modify the scrambling time and will enhance the mutual information. We also study the corrected mutual information in the backreaction geometry due to the shock wave in our three model spacetimes.

  12. Effect of Court Dimensions on Players’ External and Internal Load during Small-Sided Handball Games

    Directory of Open Access Journals (Sweden)

    Matteo Corvino

    2014-06-01

    Full Text Available The aim of this study was to investigate the effect of three different court dimensions on the internal and external load during small-sided handball games. Six male amateur handball players took part in this study and participated in three different 8-min 3vs3 (plus goalkeepers small-sided handball games (each repeated twice. The three court dimensions were 12×24m, 30×15m and 32×16m. Through Global Positioning System devices (SPI pro elite 15Hz, GPSports and video analysis, the following parameters were recorded: cyclic and acyclic movements (distance covered and number of technical actions executed, heart rate, and rating of perceived exertion (RPE. Total distance travelled increased with court dimensions (885.2m ± 66.6m in 24×12m; 980.0m ± 73.4m in 30×15m; 1095.0m ± 112.9m in 32×16m, p 5.2 m·s-1 highlighted substantial differences: playing with the 30×15m court in comparison to the 24×12m, the players covered less distance in the first speed zone (p = 0.012; ES = 0.70 and more distance in the second (p = 0.049; ES = 0.73 and third (p = 0.012; ES = 0.51 speed zones. Statistical differences were also found between the 24×12m and 32×16m courts: the players covered more distance in the second and third speed zones (p = 0.013, ES = 0.76; p = 0.023 ES = 0.69 with the 32×16m court in comparison to the 24×12m. There was no significant effect of court dimensions on the technical parameters (number of team actions, passes, piston movements toward goal and defensive activities, the number of specific handball jumps and changes of direction, and the time spent in the different heart rate zones. Considering the average data of all the experimental conditions together (24×12m, 30×15m, 32×16m, a pronounced statistical difference was highlighted between the values in first two HR zones and the last two (p < 0.05; large ES. The rating of perceived exertion was significantly higher during the drill with the 32×16m court compared with the 24

  13. Comparison of the effects of removal of chest hair with not doing so before external defibrillation on transthoracic impedance.

    Science.gov (United States)

    Sado, Daniel M; Deakin, Charles D; Petley, Graham W; Clewlow, Frank

    2004-01-01

    Chest hair contributes significantly to transthoracic impedance (TTI) during defibrillation. The magnitude of this effect has not been established using external paddles. We compared TTI in 40 men before elective cardiac surgery, and before and after shaving their chests. Chest hair causes a significant increase in TTI during external defibrillation, the magnitude of the effect being related to both the quantity of hair and force applied to the defibrillation paddles. When the chests of nonhirsute patients were shaved, a decrease in TTI occurred, which was probably related to the creation of low-impedance pathways through skin abrasions.

  14. Effect of Court Dimensions on Players' External and Internal Load during Small-Sided Handball Games.

    Science.gov (United States)

    Corvino, Matteo; Tessitore, Antonio; Minganti, Carlo; Sibila, Marko

    2014-05-01

    The aim of this study was to investigate the effect of three different court dimensions on the internal and external load during small-sided handball games. Six male amateur handball players took part in this study and participated in three different 8-min 3vs3 (plus goalkeepers) small-sided handball games (each repeated twice). The three court dimensions were 12×24m, 30×15m and 32×16m. Through Global Positioning System devices (SPI pro elite 15Hz, GPSports) and video analysis, the following parameters were recorded: cyclic and acyclic movements (distance covered and number of technical actions executed), heart rate, and rating of perceived exertion (RPE). Total distance travelled increased with court dimensions (885.2m ± 66.6m in 24×12m; 980.0m ± 73.4m in 30×15m; 1095.0m ± 112.9m in 32×16m, p 5.2 m·s(-1)) highlighted substantial differences: playing with the 30×15m court in comparison to the 24×12m, the players covered less distance in the first speed zone (p = 0.012; ES = 0.70) and more distance in the second (p = 0.049; ES = 0.73) and third (p = 0.012; ES = 0.51) speed zones. Statistical differences were also found between the 24×12m and 32×16m courts: the players covered more distance in the second and third speed zones (p = 0.013, ES = 0.76; p = 0.023 ES = 0.69) with the 32×16m court in comparison to the 24×12m. There was no significant effect of court dimensions on the technical parameters (number of team actions, passes, piston movements toward goal and defensive activities), the number of specific handball jumps and changes of direction, and the time spent in the different heart rate zones. Considering the average data of all the experimental conditions together (24×12m, 30×15m, 32×16m), a pronounced statistical difference was highlighted between the values in first two HR zones and the last two (p games can be used to manipulate both external and internal loads on the players. Key pointsTo cover the specific game demands, more specific

  15. Specifics of heat and mass transfer in spherical dimples under the effect of external factors

    Science.gov (United States)

    Shchukin, A. V.; Il'inkov, A. V.; Takmovtsev, V. V.; Khabibullin, I. I.

    2017-06-01

    The specifics are examined of heat transfer enhancement with spherical dimples under the effect of factors important for practice and characteristic of cooling systems of gas-turbine engines and power units. This experimental investigation deals with the effect of the following factors on the flow in a channel with hemispherical dimples: continuous air swirl in an annulus with dimples on its concave wall, dimples on the convex or concave wall of a curved rectangular channel, imposition of regular velocity fluctuations on the external flow in a straight rectangular channel, and adverse or favorable pressure gradient along the flow direction. The flow is turbulent. Reynolds numbers based on the channel hydraulic diameter are on the order of 104. Results of the investigation of a model of a two-cavity diffuser dimple proposed by the authors are presented. It has been found that results for channels with spherical dimples and for smooth channels differ not only quantitatively but also qualitatively. Thus, if the effect of centrifugal mass forces on convex and concave surfaces with hemispherical dimples and in a smooth channel is almost the same (quantitative and qualitative indicators are identical), the pressure gradient in the flow direction brings about the drastically opposite results. At the same time, the quantitative contribution to a change in heat transfer in hemispherical dimples is different and depends on the impact type. The results are discussed with the use of physical models created on the basis of the results of flow visualization studies and data on the turbulence intensity, pressure coefficient, etc. Results of the investigations suggest that application of spherical dimples under nonstandard conditions requires the calculated heat transfer to be corrected to account for one or another effect.

  16. Electronic structure of a spherical quantum dot: Effects of the Kratzer potential, hydrogenic impurity, external electric and magnetic fields

    Science.gov (United States)

    Dehyar, A.; Rezaei, G.; Zamani, A.

    2016-10-01

    In the present work, we have investigated the simultaneous effects of external electric and magnetic fields on the energy spectrum of an electron bound to an impurity confined in a spherical quantum dot with Kratzer potential. To this end, energy eigenvalues are obtained using the asymptotic iteration method. The energy dependencies upon the confinement potential and external fields are reported. Our results indicate that the confinement potential, external electric and magnetic fields have a great influence on the energy eigenvalues of the system. We found that, an increase in the magnetic field increases the energy eigenvalues of the states with positive magnetic quantum number, m ≽ 0 . While, the states with negative m decrease, reaching to their minimum values and increase again, with increasing the magnetic field. Moreover, an increase in electric field strength leads to decrease the confinement effects and energy eigenvalues of the system.

  17. Cognitive Abilities, Social Adaptation, and Externalizing Behavior Problems in Childhood and Adolescence: Specific Cascade Effects Across Development.

    Science.gov (United States)

    Racz, Sarah Jensen; Putnick, Diane L; Suwalsky, Joan T D; Hendricks, Charlene; Bornstein, Marc H

    2016-11-04

    Children's and adolescents' cognitive abilities, social adaptation, and externalizing behaviors are broadly associated with each other at the bivariate level; however, the direction, ordering, and uniqueness of these associations have yet to be identified. Developmental cascade models are particularly well-suited to (1) discern unique pathways among psychological domains and (2) model stability in and covariation among constructs, allowing for conservative tests of longitudinal associations. The current study aimed to identify specific cascade effects among children's cognitive abilities, social adaptation, and externalizing behaviors, beginning in preschool and extending through adolescence. Children (46.2 % female) and mothers (N = 351 families) provided data when children were 4, 10, and 14 years old. Cascade effects highlighted significant stability in these domains. Unique longitudinal associations were identified between (1) age-10 cognitive abilities and age-14 social adaptation, (2) age-4 social adaptation and age-10 externalizing behavior, and (3) age-10 externalizing behavior and age-14 social adaptation. These findings suggest that children's social adaptation in preschool and externalizing behavior in middle childhood may be ideal intervention targets to enhance adolescent well-being.

  18. Spatiotemporal complexity of a predator-prey system with the effect of noise and external forcing

    Energy Technology Data Exchange (ETDEWEB)

    Rao Feng [Institute of Nonlinear Analysis, College of Mathematics and Information Science, Wenzhou University, Wenzhou 325035 (China); Wang Weiming [Institute of Nonlinear Analysis, College of Mathematics and Information Science, Wenzhou University, Wenzhou 325035 (China)], E-mail: weimingwang2003@163.com; Li Zhenqing [Laboratory of Quantitative Vegetation Ecology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093 (China)

    2009-08-30

    In this paper, we present a spatial version of the Ivlev-type predator-prey model which contains some important factors, such as noise on predator, external periodic forcing and diffusion processes on both predator and prey. From the numerical results, we know that noise or external periodic forcing can induce instability and enhance the oscillation of the species density, and the cooperation between noise and external periodic forcing inherent to the deterministic dynamics of periodically driven models gives rise to the appearance of a rich transport phenomenology. Furthermore, we demonstrate that the spatially extended system exhibits a resonant patterns and frequency-locking phenomena. Our results show that noise and external periodic forcing play a prominent role in the predator-prey model.

  19. The Effect of External Factors on Consumption Electricity Loads Forecasting using Fuzzy Takagi-Sugeno Kang

    National Research Council Canada - National Science Library

    Gayatri Dwi Santika; wayan f mahmudy

    2017-01-01

    .... The results of the study came to the conclusion that Fuzzy Inference System Sugeno method using external factors to forecast the consumption of electrical load gives a better result than Fuzzy...

  20. Acute effect of static stretching on power output during concentric dynamic constant external resistance leg extension.

    Science.gov (United States)

    Yamaguchi, Taichi; Ishii, Kojiro; Yamanaka, Masanori; Yasuda, Kazunori

    2006-11-01

    The purpose of the present study was to clarify the effect of static stretching on muscular performance during concentric isotonic (dynamic constant external resistance [DCER]) muscle actions under various loads. Concentric DCER leg extension power outputs were assessed in 12 healthy male subjects after 2 types of pretreatment. The pretreatments included (a) static stretching treatment performing 6 types of static stretching on leg extensors (4 sets of 30 seconds each with 20-second rest periods; total duration 20 minutes) and (b) nonstretching treatment by resting for 20 minutes in a sitting position. Loads during assessment of the power output were set to 5, 30, and 60% of the maximum voluntary contractile (MVC) torque with isometric leg extension in each subject. The peak power output following the static stretching treatment was significantly (p extensive static stretching significantly reduces power output with concentric DCER muscle actions under various loads. Common power activities are carried out by DCER muscle actions under various loads. Therefore, the result of the present study suggests that relatively extensive static stretching decreases power performance.

  1. Effect of external electric field on morphology of copper phthalocyanine-fullerene blended films during annealing

    Science.gov (United States)

    Parhi, Anukul Prasad; Iyer, S. Sundar Kumar

    2016-03-01

    The thin-film morphology and segregated phases of constituents in blends of organic semiconductors play an important role in determining the performance of devices fabricated with these constituents. In this study, we explored the effect of an external electric field applied during annealing on the morphology and phase of blended films of two popular organic semiconductors, copper pthalocyanine (CuPc) and buckminsterfullerene (C60). Films of different blend ratios annealed at various temperatures in both the presence and absence of an electric field were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD), and ultraviolet-visible (UV-vis) spectroscopy. The characteristics of annealed pristine CuPc films were also included for comparison. The observed changes in the properties of the blended films following the annealing, including the abrupt phase segregation of the blended constituents in the films, are discussed. The polarizability of the molecules was calculated using density functional theory (DFT) to explain the interaction, stacking, and segregation of the molecules in the blend. The results showed that application of an electric field during annealing of the blended films is an additional control parameter that can help tune the properties of the blended film. [Figure not available: see fulltext.

  2. Is the P3 amplitude reduction seen in externalizing psychopathology attributable to stimulus sequence effects?

    Science.gov (United States)

    Gilmore, Casey S; Malone, Stephen M; Iacono, William G

    2012-02-01

    P3 amplitude reduction (P3-AR) is associated with biological vulnerability to a spectrum of externalizing (EXT) disorders, such as conduct disorder, antisocial behavior, and substance use disorders. P3 amplitude, however, can be affected by the context within which it is measured, for example, by the position of the target in the sequence of stimuli during an oddball task. We hypothesized that EXT-related P3-AR may be due to attention or working memory deficits in EXT that would weaken these stimulus sequence effects. Using a community-based sample of adolescent males, we examined the relationship between P3 and EXT as a function of the number of standards preceding the target. Higher EXT was associated with significantly smaller P3 amplitude, regardless of the number of standards preceding the target. These results suggest that P3-AR in EXT does not vary as a function of stimulus sequence, further supporting P3-AR as an endophenotype for EXT disorders.

  3. The effects of physiologic dynamic compression on bone healing under external fixation

    Energy Technology Data Exchange (ETDEWEB)

    Aro, H.T.; Kelly, P.J.; Lewallen, D.G.; Chao, E.Y. (Mayo Clinic/Mayo Foundation, Rochester, MN (USA))

    1990-07-01

    The effects of early physiologic dynamic compression on fracture healing were studied in the dog. Transverse midtibial osteotomies were performed bilaterally and stabilized with a relatively rigid external fixation system in a neutralization mode (800 microns) to prevent compression of the osteotomy ends during weight bearing. On the 15th day, one osteotomy in each animal was subjected to dynamic compression through weight bearing by release of the fixator-telescoping mechanism (axial dynamization), while the other side remained unchanged as the control. Analysis of sequential roentgenograms showed that the callus distribution was more symmetric on the dynamic compression side. The two sides showed no significant differences in quantitative technetium-99 bone scans or in osteotomy-site blood flow. There were no statistical differences in new bone formation, bone porosity, or maximum torque between sides. The fixation had maintained the initially created osteotomy gap on the control side and tended to unite through a gap-healing mechanism. The dynamic compression side showed reduction in gap size and union by more of a contact-healing mechanism. There were no statistical differences in the rate of pin loosening, but its distribution according to pin location was significantly different between the two sides.

  4. External urethral stenosis: a latent effect of sulfur mustard two decades post-exposure.

    Science.gov (United States)

    Emadi, Seyed Naser; Hosseini-Khalili, Alireza; Soroush, Mohammadreza; Ardakani, Mohammadreza Khodaei; Ghassemi-Broumand, Mohammad; Davoodi, Seyed Masoud; Amirani, Omolbanin; Haines, David

    2009-09-01

    Sulfur mustard (SM), a chemical weapon used widely during World War I and against Iranians during the Iran-Iraq War of the 1980s, causes massive inflammatory tissue damage in the immediate post-exposure period, resulting in debilitating chronic disease in years to decades following contact with the agent. These syndromes most often are pathologies of the lungs, eyes, and skin, the primary target organs of SM. Typically, they are characterized by severe and increasingly painful inflammation, often accompanied by fibrosis and constriction of the anatomic channels needed for normal life, such as the small airways of the lungs and, in the present report, the urethra. The present case study is a 43-year-old man with a history of heavy SM exposure to the groin in 1984. Within 1 year after exposure, the patient was found to have developed meatal stricture, occlusion of the external urethral meatus, and difficulty in urination. Two years post-exposure, he underwent ventral meatotomy and meatoplasty. This case presents a unique example of the latent effects of SM exposure to the groin, and will be of value in the prevention of similar injury and complications to persons at risk of SM exposure in the future.

  5. Effect of external stress on deuteride (hydride) precipitation in Zircaloy-4 using in situ neutron diffraction

    Science.gov (United States)

    Lin, Jun-li; An, Ke; Stoica, Alexandru D.; Heuser, Brent J.

    2017-04-01

    In situ neutron diffraction is utilized to study the deuteride (hydride) precipitation behavior in a cold-worked stress-relieved (CWSR) Zircaloy-4 material upon cooling from 420 °C to room temperature with a 78 MPa external stress applied along the rolling direction (RD) of the material. Two banks detector capture the diffraction signal from two principal directions of the specimen, the normal direction (ND) and the rolling direction (RD). The evolution of deuterium concentration in zirconium solid solution along the two specimen directions is measured by studying the δ-(220) peak intensity, applying the Rietveld refinement method to the diffraction data and using the measured zirconium c-axis lattice distortion. The deuterium concentration is observed to be higher for zirconium grains in the ND than the RD. The terminal solid solubility of precipitation (TSSp) for deuterium in the solution is then described using the Arrhenius equation. It is observed that the applied stress reduces the energy term Q in the Arrhenius equation when compared with the unstressed Q values from the work of others. A model by Puls is applied to study the effect of stress on deuterium solubility, with polycrystalline hydride precipitation strain calculated using the Kearns factor representative of the studied material. The experimental result does not agree with the model prediction of Puls.

  6. Enhanced External Counterpulsation Inducing Arterial Hemodynamic Variations and Its Chronic Effect on Endothelial Function

    Institute of Scientific and Technical Information of China (English)

    DU Jian-hang; WU Gui-fu; ZHENG Zhen-sheng; DAI Gang; FENG Ming-zhe

    2014-01-01

    To make clear the precise hemodynamic mechanism underlying the anti-atherogenesis benefit of enhanced external couterpulsation(EECP) treatment, and to investigate the proper role of some important hemodynamic factors during the atherosclerotic progress, a comprehensive study combining long-term animal experiment and numerical solving was conducted in this paper. An experimentally induced hypercholesterolemic porcine model was developed and the chronic EECP intervention was subjected. Basic hemodynamic measurement was performed in vivo, as well as the arterial endothelial samples were extracted for physiological examination. Meanwhile, a numerical model was introduced to solve the complex hemodynamic factors such as WSS and OSI. The results show that EECP treatment resulted in significant increase of the instant levels of arterial WSS, blood pressure, and OSI. During EECP treatment, the instant OSI level of the common carotid arteries over cardiac cycles raised to a mean value of 8.58 ×10-2 ±2.13 ×10-2. Meanwhile, the chronic intervention of EECP treatment significantly reduced the atherosclerotic lesions in abdominal aortas and the endothelial cellular adherence. The present study suggests that the unique blood flow pattern induced by EECP treatment and the augmentation of WSS level in cardiac cycles may be the most important hemodynamic mechanism that contribute to its anti-atherogenesis effect. And as one of the indices that cause great concern in current hemodynamic study, OSI may not play a key role during the initiation of atherosclerosis.

  7. External gamma irradiation-induced effects in early-life stages of zebrafish, Danio rerio

    Energy Technology Data Exchange (ETDEWEB)

    Gagnaire, B., E-mail: beatrice.gagnaire@irsn.fr [Institut de Radioprotection et de Sureté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France); Cavalié, I. [Institut de Radioprotection et de Sureté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France); Pereira, S. [Neolys Diagnostics, Lyon 69373 (France); Floriani, M.; Dubourg, N.; Camilleri, V.; Adam-Guillermin, C. [Institut de Radioprotection et de Sureté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France)

    2015-12-15

    Highlights: • The present study aimed to evaluate the effects of gamma rays on zebrafish larvae. • Different techniques were used: gene expression, biochemistry, microscopy and macroscopical observations. • The results showed that gamma irradiation can alter embryo-larval development at several levels of organization. - Abstract: In the general context of validation of tools useful for the characterization of ecological risk linked to ionizing radiation, the effects of an external gamma irradiation were studied in zebrafish larvae irradiated for 96 h with two dose rates: 0.8 mGy/d, which is close to the level recommended to protect ecosystems from adverse effects of ionizing radiation (0.24 mGy/d) and a higher dose rate of 570 mGy/d. Several endpoints were investigated, such as mortality, hatching, and some parameters of embryo-larval development, immunotoxicity, apoptosis, genotoxicity, neurotoxicity and histological alterations. Results showed that an exposure to gamma rays induced an acceleration of hatching for both doses and a decrease of yolk bag diameter for the highest dose, which could indicate an increase of global metabolism. AChE activity decreased with the low dose rate of gamma irradiation and alterations were also shown in muscles of irradiated larvae. These results suggest that gamma irradiation can induce damages on larval neurotransmission, which could have repercussions on locomotion. DNA damages, basal ROS production and apoptosis were also induced by irradiation, while ROS stimulation index and EROD biotransformation activity were decreased and gene expression of acetylcholinesterase, choline acetyltransferase, cytochrome p450 and myeloperoxidase increased. These results showed that ionizing radiation induced an oxidative stress conducting to DNA damages. This study characterized further the modes of action of ionizing radiation in fish.

  8. Effects of automated external lubrication on tablet properties and the stability of eprazinone hydrochloride.

    Science.gov (United States)

    Yamamura, Takahiro; Ohta, Tomoaki; Taira, Toshinari; Ogawa, Yutaka; Sakai, Yasuyuki; Moribe, Kunikazu; Yamamoto, Keiji

    2009-03-31

    We investigated the advantages of an external lubrication technique for tableting. A newly developed external lubricating system was applied to tableting in a rotary tablet press using magnesium stearate. The resulting tablets were compared with tablets produced by the conventional internal lubrication method, in which lubricant is blended before tableting. As a model API, we chose eprazinone hydrochloride, because it is easily hydrolyzed by alkaline lubricant. The amount of lubricant required to prevent sticking with external lubrication was only 1/13th of that required with internal lubrication. External lubrication increased tablet crushing strength by 40%, without prolonging tablet disintegration time, and improved the residual ratio of eprazinone hydrochloride in tablets stored under stress conditions for 4 weeks by 10%. The distribution of lubricant on the surface of externally lubricated tablets was observed by scanning electron microscopy after the preparation by focused ion beam milling. The lubricant had formed a layer on the tablet surface. At the central part of the tablet surface, this layer was much thinner than at the edges, and remained extremely thin even when there was excess magnesium stearate. This is the first report to describe the distribution of lubricant on the surface of externally lubricated tablets.

  9. Cost-effectiveness of external cephalic version for term breech presentation

    Directory of Open Access Journals (Sweden)

    Carvalho Brendan

    2010-01-01

    Full Text Available Abstract Background External cephalic version (ECV is recommended by the American College of Obstetricians and Gynecologists to convert a breech fetus to vertex position and reduce the need for cesarean delivery. The goal of this study was to determine the incremental cost-effectiveness ratio, from society's perspective, of ECV compared to scheduled cesarean for term breech presentation. Methods A computer-based decision model (TreeAge Pro 2008, Tree Age Software, Inc. was developed for a hypothetical base case parturient presenting with a term singleton breech fetus with no contraindications for vaginal delivery. The model incorporated actual hospital costs (e.g., $8,023 for cesarean and $5,581 for vaginal delivery, utilities to quantify health-related quality of life, and probabilities based on analysis of published literature of successful ECV trial, spontaneous reversion, mode of delivery, and need for unanticipated emergency cesarean delivery. The primary endpoint was the incremental cost-effectiveness ratio in dollars per quality-adjusted year of life gained. A threshold of $50,000 per quality-adjusted life-years (QALY was used to determine cost-effectiveness. Results The incremental cost-effectiveness of ECV, assuming a baseline 58% success rate, equaled $7,900/QALY. If the estimated probability of successful ECV is less than 32%, then ECV costs more to society and has poorer QALYs for the patient. However, as the probability of successful ECV was between 32% and 63%, ECV cost more than cesarean delivery but with greater associated QALY such that the cost-effectiveness ratio was less than $50,000/QALY. If the probability of successful ECV was greater than 63%, the computer modeling indicated that a trial of ECV is less costly and with better QALYs than a scheduled cesarean. The cost-effectiveness of a trial of ECV is most sensitive to its probability of success, and not to the probabilities of a cesarean after ECV, spontaneous reversion

  10. Effects of low-dose fractionated external irradiation on metabolic and structural characteristics of rat thyroid

    Energy Technology Data Exchange (ETDEWEB)

    Nadolnik, L.; Niatsetskaya, Z. [Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno (Belarus)

    2006-07-01

    Full text of publication follows: The problem of thyroid radiosensitivity to the effect of low dose external ionizing irradiation presently seems to be the least studied, and the experimental findings - the most contradictory. The aim of the work was to study the effects of long-term low-dose fractionated irradiation on the iodide metabolism and structure of the thyroid. Female Wistar rats weighing 140-160 g were irradiated 20 times (5 times a week, for 4 weeks) using a 60 Co installation. The single absorbed doses were 0.1, 0.25 and 0.5 Gy and the total ones - 2.0, 5.0 and 10.0 Gy, respectively. The animals were decapitated after 1 day, 4 and 24 weeks following the last irradiation. The thyroid tissue was used to assay for thyro-peroxidase (T.P.O.) activity as well as total, protein -bound and free iodide concentrations. Microscopic and morphometric examination of histologic thyroid preparations was carried out. Blood was assayed for thyroxin (T4) and triiodothyronine (T3) concentrations. After a day following the irradiation, the thyroid showed a pronounced increase in the concentration of total iodide (30.0-54.4%) as well in that of free (32.1-60.8%) and protein-bound ones (24.4-37.4%). The most pronounced iodide concentration elevation was noted in the 0.1 -Gy animals, with thyroid T.P.O. activity being raised by 48.0%. Only the 0.5 Gy-group had 1.4-1.5-fold reduced thyroid hormone levels. Four weeks after the irradiation, studied parameters of irradiated rats were brought back to the control values, except for the 0.5 Gy-group. However, after 24-weeks, the 0.5-and 0.25- irradiated rats experienced a 12-20% thyroid weight elevation in comparison with the control. The thyroid of these animals demonstrated reduced contents of total and free iodide as well as T.P.O. activity by 24.5 and 34.8%. The 0.1 Gy-group had a 1.7-fold increased T.P.O. activity. The concentration of the thyroid hormones was maintained diminished only in the 0.5 Gy -irradiated group. However

  11. [Effect on Fermi Resonance by Some External Fields: Investigation of Fermi Resonance According to Raman Spectra].

    Science.gov (United States)

    Jiang, Xiu-lan; Sun, Cheng-lin; Zhou, Mi; Li, Dong-fei; Men, Zhi-wei; Li, Zuo-wei; Gao, Shu-qin

    2015-03-01

    Fermi resonance is a phenomenon of molecular vibrational coupling and energy transfer occurred between different groups of a single molecule or neighboring molecules. Many properties of Fermi resonance under different external fields, the investigation method of Raman spectroscopy as well as the application of Fermi resonance, etc need to be developed and extended further. In this article the research results and development about Fermi resonance obtained by Raman spectral technique were introduced systematically according to our work and the results by other researchers. Especially, the results of the behaviors of intramolecular and intermolecular Fermi resonance of some molecules under some external fields such as molecular field, pressure field and temperature field, etc were investigated and demonstrated in detail according to the Raman spectra obtained by high pressure DAC technique, temperature variation technique as well as the methods we planed originally in our group such as solution concentration variation method and LCOF resonance Raman spectroscopic technique, and some novel properties of Fermi resonance were found firstly. Concretely, (1) Under molecular field. a. The Raman spectra of C5H5 N in CH3 OH and H2O indicates that solvent effect can influence Fermi resonance distinctly; b. The phenomena of the asymmetric movement of the Fermi resonance doublets as well as the fundamental involved is tuned by the Fermi resonance which had not been found by other methods were found firstly by our variation solution concentration method; c. The Fermi resonance properties can be influenced distinctly by the molecular group reorganization induced by the hydrogen bond and anti-hydrogen bond in solution; d. Fermi resonance can occurred between C7 H8 and m-C8H10, and the Fermi resonance properties behave quite differently with the solution concentration; (2) Under pressure field. a. The spectral lines shift towards high wavenumber with increasing pressure, and

  12. Hypofractionated external beam radiotherapy as retreatment for symptomatic non-small-cell lung carcinoma: an effective treatment?

    NARCIS (Netherlands)

    Kramer, G.W.P.M.; Gans, S.; Ullmann, E.F.; Meerbeeck, J.P. van; Legrand, C.; Leer, J.W.H.

    2004-01-01

    PURPOSE: To evaluate prospectively the efficacy, toxicity, and duration of the palliative effect of retreatment with external beam radiotherapy in symptomatic patients with recurrent non-small-cell lung cancer. METHODS AND MATERIALS: Twenty-eight symptomatic patients with local recurrence of

  13. The MOND External Field Effect on the Dynamics of the Globular Clusters: General Considerations and Application to NGC 2419

    Science.gov (United States)

    Derakhshani, Kamran

    2014-03-01

    In this paper, we investigate the external field effect in the context of the MOdified Newtonian Dynamics (MOND) on the surface brightness and velocity dispersion profiles of globular clusters (GCs). Using N-MODY, which is an N-body simulation code with a MOND potential solver, we show that the general effect of the external field for diffuse clusters, which obey MOND in most of their parts, is that it pushes the dynamics toward the Newtonian regime. On the other hand, for more compact clusters, which are essentially Newtonian in their inner parts, the external field is effective mainly in the outer parts of compact clusters. As a case study, we then choose the remote Galactic GC NGC 2419. By varying the cluster mass, half-light radius, and mass-to-light ratio, we aim to find a model that will reproduce the observational data most effectively, using N-MODY. We find that even if we take the Galactic external field into account, a Newtonian Plummer sphere represents the observational data better than MOND to an order of magnitude in terms of the total χ2 of surface brightness and velocity dispersion.

  14. The mond external field effect on the dynamics of the globular clusters: general considerations and application to NGC 2419

    Energy Technology Data Exchange (ETDEWEB)

    Derakhshani, Kamran, E-mail: kderakhshani@iasbs.ac.ir [Institute for Advanced Studies in Basic Sciences, P. O. Box 45195-1159 Zanjan (Iran, Islamic Republic of)

    2014-03-01

    In this paper, we investigate the external field effect in the context of the MOdified Newtonian Dynamics (MOND) on the surface brightness and velocity dispersion profiles of globular clusters (GCs). Using N-MODY, which is an N-body simulation code with a MOND potential solver, we show that the general effect of the external field for diffuse clusters, which obey MOND in most of their parts, is that it pushes the dynamics toward the Newtonian regime. On the other hand, for more compact clusters, which are essentially Newtonian in their inner parts, the external field is effective mainly in the outer parts of compact clusters. As a case study, we then choose the remote Galactic GC NGC 2419. By varying the cluster mass, half-light radius, and mass-to-light ratio, we aim to find a model that will reproduce the observational data most effectively, using N-MODY. We find that even if we take the Galactic external field into account, a Newtonian Plummer sphere represents the observational data better than MOND to an order of magnitude in terms of the total χ{sup 2} of surface brightness and velocity dispersion.

  15. The MOND External Field Effect on the Dynamics of the Globular Clusters: General Considerations and Application to NGC 2419

    CERN Document Server

    Derakhshani, Kamran

    2014-01-01

    In this paper, we investigate the external field effect in the context of the MOdified Newtonian Dynamics (MOND) on the surface brightness and velocity dispersion profiles of globular clusters (GCs). Using N-MODY, which is an N-body simulation code with a MOND potential solver, we show that the general effect of the external field for diffuse clusters, which obey MOND in most of their parts, is that it pushes the dynamics towards the Newtonian regime. On the other hand, for more compact clusters, which are essentially Newtonian in their inner parts, the external field is effective mainly in the outer parts of compact clusters. As a case study, we then choose the remote Galactic GC NGC 2419. By varying the cluster mass, half-light radius, and mass-to-light ratio we aim to find a model that will reproduce the observational data most effectively, using N-MODY. We find that even if we take the Galactic external field into account, a Newtonian Plummer sphere represents the observational data better than MOND to an...

  16. The effectiveness of parent management training—oregon model in clinically referred children with externalizing behavior problems in the netherlands.

    NARCIS (Netherlands)

    Thijssen, Jill; Vink, G.; Muris, Peter; de Ruiter, Corine

    2016-01-01

    The present study examined the effectiveness of parent management training—Oregon model (PMTO) as a treatment for children with externalizing behavior problems in The Netherlands. Clinically referred children (N = 146) aged 4–11 years and their parents were partly randomized to either PMTO (n = 91)

  17. The Effects of Idealized and Grounded Materials on Learning, Transfer, and Interest: An Organizing Framework for Categorizing External Knowledge Representations

    Science.gov (United States)

    Belenky, Daniel M.; Schalk, Lennart

    2014-01-01

    Research in both cognitive and educational psychology has explored the effect of different types of external knowledge representations (e.g., manipulatives, graphical/pictorial representations, texts) on a variety of important outcome measures. We place this large and multifaceted research literature into an organizing framework, classifying three…

  18. The Effects of Visual Cues and Learners' Field Dependence in Multiple External Representations Environment for Novice Program Comprehension

    Science.gov (United States)

    Wei, Liew Tze; Sazilah, Salam

    2012-01-01

    This study investigated the effects of visual cues in multiple external representations (MER) environment on the learning performance of novices' program comprehension. Program codes and flowchart diagrams were used as dual representations in multimedia environment to deliver lessons on C-Programming. 17 field independent participants and 16 field…

  19. Theoretical study on coupling effects of modulation depth between two photorefractive phase gratings with an external applied field

    Institute of Scientific and Technical Information of China (English)

    YUAN Baohong; ZHOU Zhongxiang; HOU Chunfeng; SUN Xiudong

    2001-01-01

    We used the perturbation expanding method to the hopping model and studied coupling effects of the modulation depth between two photorefractive phase gratings stored in one point with an external applied DC electric field . It has been found that the modulation depth of one of the two gratings seriously affects the spatial-charge field of the other grating.

  20. Frequency Shift and Sub-band Effect in Pair-Production Process Under Adiabatic Closing the External Field

    Science.gov (United States)

    Song, Xinfang; Wang, Wenyuan; Fu, Libin

    2016-09-01

    Oscillating electric field is chosen to investigate the electron-positron pair production process by using a quantum kinetic theory and the effective mass model [Phys. Rev. Lett. 112, 050402 (2014)]. The particle yield exhibits a characteristic oscillatory structure which is related to the multi-photon thresholds. The true peak positions are typically slightly above the naive threshold estimate, which is defined as frequency shift. During the numerical calculations, we find the frequency shift can be affected by the system parameters under adiabatic closing the external field, it is worthwhile to study in detail. In this paper, we investigate the frequency shift and the sub-band effect in electron-positron pair production with oscillating electric field. First, a quantum kinetic theory and the effective mass are presented to obtain the frequency shift, the results are fitted very well. And we find the frequency shift and the sub-band effect can be influenced by pulse duration, photon number, and strength of the external field. The frequency shift becomes evident as increases of photon number and the external field strength. The sub-band width is relatively lower at longer pulse duration, higher photon number region, and weaker external field. The results shown in the paper are helpful for understanding multi-photon pair production process in the strong field.

  1. Randomized trial of the effect of antipyresis by metamizol, propacetamol or external cooling on metabolism, hemodynamics and inflammatory response.

    Science.gov (United States)

    Gozzoli, Valerio; Treggiari, Miriam M; Kleger, Gian-Reto; Roux-Lombard, Pascale; Fathi, Marc; Pichard, Claude; Romand, Jacques-André

    2004-03-01

    We investigated the metabolic, hemodynamic, and inflammatory responses of pharmacological and physical therapies aimed at reducing body temperature in febrile critically ill patients. Open-label, randomized trial in a surgical ICU in a tertiary university hospital. Thirty analgosedated, mechanically ventilated patients with a temperature of 38.5 degrees C or higher were randomized to receive either intravenous metamizol, intravenous propacetamol, or external cooling. Body temperature and metabolic and hemodynamic variables were recorded at baseline and during the following 4 h. Cytokine concentrations were assessed before and 4 and 12 h after the initiation of antipyresis. Body temperature decreased significantly in all treatment groups. For a 1 degrees C temperature decrease, the energy expenditure index increased by 5% with external cooling and decreased by 7% and 8% in the metamizol and propacetamol groups, respectively. Metamizol induced a significant decrease in mean arterial pressure and urine output compared to baseline and to the other two groups. C-reactive protein increased over time, but compared to the other groups it was significantly lower in patients receiving metamizol after 4 h. Cytokine concentrations were not different among the three groups or over time, although interleukin 6 tended to decrease over time in the metamizol group. Metamizol, propacetamol, and external cooling equally reduced temperature. Considering the undesirable hemodynamic effects, metamizol should not be considered the first antipyretic choice in unstable patients. Propacetamol or external cooling should be preferred, although the latter should be avoided in patients unlikely to tolerate the increased metabolic demand induced by external cooling.

  2. Analysis techniques and performance of the Domino Ring Sampler version 4 based readout for the MAGIC telescopes

    CERN Document Server

    Sitarek, Julian; Mazin, Daniel; Paoletti, Riccardo; Tescaro, Diego

    2013-01-01

    Recently the readout of the MAGIC telescopes has been upgraded to a new system based on the Domino Ring Sampler version 4 chip. We present the analysis techniques and the signal extraction performance studies of this system. We study the behaviour of the baseline, the noise, the cross-talk, the linearity and the time resolution. We investigate also the optimal signal extraction. In addition we show some of the analysis techniques specific to the readout based on the Domino Ring Sampler version 2 chip, previously used in the MAGIC II telescope.

  3. 从NT Domino服务器到Lotus Domino 向AS/400的移植方法

    Institute of Scientific and Technical Information of China (English)

    郁春江; 邓伟; 等

    2002-01-01

    AS/400以其卓越的性能,越来越受到用户的青睐,把原来基于其它平台的Domino系统移植到AS/400上成为我们首先面临的问题,本文主要介绍了如何在对Notes client影响最小的情况下,把NT Domino server移植到Lotus Domino for AS/400上。

  4. A Novel Leakage-tolerant Domino Logic Circuit With Feedback From Footer Transistor In Ultra Deep Submicron CMOS

    DEFF Research Database (Denmark)

    Moradi, Farshad; Peiravi, Ali; Mahmoodi, Hamid

    As the CMOS manufacturing process scales down into the ultra deep sub-micron regime, the leakage current becomes an increasingly more important consideration in VLSI circuit design. In this paper, a high speed and noise immune domino logic circuit is presented which uses the property of the footer...... transistor to alleviate the sensitivity of the dynamic node to noise and results in improved performance. The new circuit has been added to conventional footed standard domino logic for highly improving leakage tolerance, especially at the beginning of the evaluation phase. According to simulation results...

  5. Organocatalytic Domino Oxa-Michael/1,6-Addition Reactions: Asymmetric Synthesis of Chromans Bearing Oxindole Scaffolds.

    Science.gov (United States)

    Zhao, Kun; Zhi, Ying; Shu, Tao; Valkonen, Arto; Rissanen, Kari; Enders, Dieter

    2016-09-19

    An asymmetric organocatalytic domino oxa-Michael/1,6-addition reaction of ortho-hydroxyphenyl-substituted para-quinone methides and isatin-derived enoates has been developed. In the presence of 5 mol % of a bifunctional thiourea organocatalyst, this scalable domino reaction affords 4-phenyl-substituted chromans bearing spiro-connected oxindole scaffolds and three adjacent stereogenic centers in good to excellent yields (up to 98 %) and with very high stereoselectivities (up to >20:1 d.r., >99 % ee). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. Stereospecific Synthesis of 2-Iminothiazolidines via Domino Ring-Opening Cyclization of Activated Aziridines with Aryl- and Alkyl Isothiocyanates.

    Science.gov (United States)

    Bhattacharyya, Aditya; Kavitha, C V; Ghorai, Manas K

    2016-08-05

    Lewis acid catalyzed domino ring-opening cyclization of activated aziridines with aryl and alkyl isothiocyanates has been accomplished leading to the formation of a wide variety of highly substituted and functionalized 2-iminothiazolidines with excellent diastereo- and enantiospecificity (de, ee up to >99%). The reaction proceeds via a Lewis acid catalyzed SN2-type ring-opening of the activated aziridine followed by a concomitant 5-exo-dig cyclization in a domino fashion to furnish the 2-iminothiazolidine derivative in excellent yields (up to 99%).

  7. Domino-Fluorination-Protodefluorination Enables Decarboxylative Cross-Coupling of α-Oxocarboxylic Acids with Styrene via Photoredox Catalysis.

    Science.gov (United States)

    Zhang, Muliang; Xi, Junwei; Ruzi, Rehanguli; Li, Nan; Wu, Zhongkai; Li, Weipeng; Zhu, Chengjian

    2017-09-15

    Domino-fluorination-protodefluorination decarboxylative cross-coupling of α-keto acids with styrene has been developed via photoredox catalysis. The critical part of this strategy is the formation of the carbon-fluorine (C-F) bond by the capture of a carbon-centered radical intermediate, which will overcome side reactions during the styrene radical functionalization process. Experimental studies have provided evidence indicating a domino-fluorination-protodefluorination pathway with α-keto acid initiating the photoredox cycle. The present catalytic protocol also affords a novel approach for the construction of α,β-unsaturated ketones under mild conditions.

  8. Palladium-catalyzed domino C-H/N-H functionalization: an efficient approach to nitrogen-bridged heteroacenes.

    Science.gov (United States)

    Kamimoto, Natsuyo; Schollmeyer, Dieter; Mitsudo, Koichi; Suga, Seiji; Waldvogel, Siegfried R

    2015-05-26

    Palladium-catalyzed domino C-H/N-H functionalization for the synthesis of novel nitrogen-bridged thienoacenes and 10H-benzo[4,5]thieno[3,2-b]indole derivatives from dihaloarene is reported. This domino sequence consists of initial C-H functionalization of the benzo[b]thiophene moiety, followed by Buchwald-Hartwig coupling. This transformation is also useful for the synthesis of highly π-extended compounds. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. GENERAL: Effect of Spatial Dimension and External Potential on Joule-Thomson Coefficients of Ideal Bose Gases

    Science.gov (United States)

    Yuan, Du-Qi; Wang, Can-Jun

    2010-04-01

    Based on the form of the n-dimensional generic power-law potential, the state equation and the heat capacity, the analytical expressions of the Joule-Thomson coefficient (JTC) for an ideal Bose gas are derived in n-dimensional potential. The effect of the spatial dimension and the external potential on the JTC are discussed, respectively. These results show that: (i) For the free ideal Bose gas, when n/s Constant, T is the thermodynamic temperature, varpii is the external field's energy), is obtained. The potential makes the JTC increase when Δ > 0, on the contrary, it makes the JTC decrease when Δ < 0. (iii) In the homogenous strong external potential, the JTC gets the maximum on the condition of kT/varpii < 1.

  10. Lopsidedness of Self-consistent Galaxies Caused by the External Field Effect of Clusters

    Science.gov (United States)

    Wu, Xufen; Wang, Yougang; Feix, Martin; Zhao, HongSheng

    2017-08-01

    Adopting Schwarzschild’s orbit-superposition technique, we construct a series of self-consistent galaxy models, embedded in the external field of galaxy clusters in the framework of Milgrom’s MOdified Newtonian Dynamics (MOND). These models represent relatively massive ellipticals with a Hernquist radial profile at various distances from the cluster center. Using N-body simulations, we perform a first analysis of these models and their evolution. We find that self-gravitating axisymmetric density models, even under a weak external field, lose their symmetry by instability and generally evolve to triaxial configurations. A kinematic analysis suggests that the instability originates from both box and nonclassified orbits with low angular momentum. We also consider a self-consistent isolated system that is then placed in a strong external field and allowed to evolve freely. This model, just like the corresponding equilibrium model in the same external field, eventually settles to a triaxial equilibrium as well, but has a higher velocity radial anisotropy and is rounder. The presence of an external field in the MOND universe generically predicts some lopsidedness of galaxy shapes.

  11. Effect of Ovality on Maximum External Pressure of Helically Coiled Steam Generator Tubes with a Rectangular Wear

    Energy Technology Data Exchange (ETDEWEB)

    Shin, Dong In; Lim, Eun Mo; Huh, Nam Su [Seoul National Univ. of Science and Technology, Seoul (Korea, Republic of); Choi, Shin Beom; Yu, Je Yong; Kim, Ji Ho; Choi, Suhn [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2013-10-15

    A structural integrity of steam generator tubes of nuclear power plants is one of crucial parameters for safe operation of nuclear power plants. Thus, many studies have been made to provide engineering methods to assess integrity of defective tubes of commercial nuclear power plants considering its operating environments and defect characteristics. As described above, the geometric and operating conditions of steam generator tubes in integral reactor are significantly different from those of commercial reactor. Therefore, the structural integrity assessment of defective tubes of integral reactor taking into account its own operating conditions and geometric characteristics, i. e., external pressure and helically coiled shape, should be made to demonstrate compliance with the current design criteria. Also, ovality is very specific characteristics of the helically coiled tube because it is occurred during the coiling processes. The wear, occurring from FIV (Flow Induced Vibration) and so on, is main degradation of steam generator tube. In the present study, maximum external pressure of helically coiled steam generator tube with wear is predicted based on the detailed 3-dimensional finite element analysis. As for shape of wear defect, the rectangular shape is considered. In particular, the effect of ovality on the maximum external pressure of helically coiled tubes with rectangular shaped wear is investigated. In the present work, the maximum external pressure of helically coiled steam generator tube with rectangular shaped wear is investigated via detailed 3-D FE analyses. In order to cover a practical range of geometries for defective tube, the variables affecting the maximum external pressure were systematically varied. In particular, the effect of tube ovality on the maximum external pressure is evaluated. It is expected that the present results can be used as a technical backgrounds for establishing a practical structural integrity assessment guideline of

  12. An efficient domino one-pot synthesis of novel spirofuran-indenoquinoxalines by vinyltriphenylphosphonium salts

    Indian Academy of Sciences (India)

    AFSHIN YAZDANI-ELAH-ABADI; MALEK-TAHER MAGHSOODLOU; RAZIEH MOHEBAT; REZA HEYDARI

    2017-06-01

    A simple and convenient multi-component domino reaction has been described for the synthesis of novel spirofuran-indenoquinoxaline derivatives. Products were obtained by a three-component condensation reaction between ninhydrin, aromatic 1,2-diamines and dialkyl ethynedicarboxylates in the presence of a catalytic amount of triphenylphosphine in CH2Cl2 at ambient temperature in excellent yields. This one-pot process produces biologically and pharmacologically significant heterocycles with the formation of five new bonds (one C–C, two C=N and two C–O) and two new rings in a single operation.

  13. Versatile synthesis of amino acid functionalized nucleosides via a domino carboxamidation reaction

    Directory of Open Access Journals (Sweden)

    Vicky Gheerardijn

    2014-11-01

    Full Text Available Functionalized oligonucleotides have recently gained increased attention for incorporation in modified nucleic acid structures both for the design of aptamers with enhanced binding properties as well as the construction of catalytic DNA and RNA. As a shortcut alternative to the incorporation of multiple modified residues, each bearing one extra functional group, we present here a straightforward method for direct linking of functionalized amino acids to the nucleoside base, thus equipping the nucleoside with two extra functionalities at once. As a proof of principle, we have introduced three amino acids with functional groups frequently used as key-intermediates in DNA- and RNAzymes via an efficient and straightforward domino carboxamidation reaction.

  14. Asymmetric synthesis of fully substituted cyclopentane-oxindoles through an organocatalytic triple Michael domino reaction.

    Science.gov (United States)

    Zou, Liang-Hua; Philipps, Arne R; Raabe, Gerhard; Enders, Dieter

    2015-01-12

    An efficient, highly stereoselective asymmetric synthesis of fully functionalized cyclopentanes bearing an oxindole moiety and several other functional groups in one pot has been developed. Key step is an organocatalytic triple Michael domino reaction forming three C-C bonds and six stereocenters, including a quaternary one. Starting from equimolar amounts of simple substrates, a high molecular complexity can be reached after a Wittig olefination in one pot. The new protocol can easily be scaled up to gram amounts. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. Domino tilings and the six-vertex model at its free-fermion point

    Energy Technology Data Exchange (ETDEWEB)

    Ferrari, Patrik L; Spohn, Herbert [Zentrum Mathematik and Physik Department, Technische Universitaet Muenchen, D-85747 Garching (Germany)

    2006-08-18

    At the free-fermion point, the six-vertex model with domain wall boundary conditions (DWBC) can be related to the Aztec diamond, a domino tiling problem. We study the mapping on the level of complete statistics for general domains and boundary conditions. This is obtained by associating with both models a set of non-intersecting lines in the Lindstroem-Gessel-Viennot (LGV) scheme. One of the consequences for DWBC is that the boundaries of the ordered phases are described by the Airy process in the thermodynamic limit.

  16. Domino tilings and the six-vertex model at its free-fermion point

    Science.gov (United States)

    Ferrari, Patrik L.; Spohn, Herbert

    2006-08-01

    At the free-fermion point, the six-vertex model with domain wall boundary conditions (DWBC) can be related to the Aztec diamond, a domino tiling problem. We study the mapping on the level of complete statistics for general domains and boundary conditions. This is obtained by associating with both models a set of non-intersecting lines in the Lindström-Gessel-Viennot (LGV) scheme. One of the consequences for DWBC is that the boundaries of the ordered phases are described by the Airy process in the thermodynamic limit.

  17. Hysteresis analysis in dye-sensitized solar cells based on external bias field effects

    Science.gov (United States)

    Wu, Fan; Li, Xiaoyi; Tong, Yanhua; Zhang, Tiansheng

    2017-02-01

    The current density-voltage (J-V) hysteresis phenomenon occurs in perovskite solar cells as well as dye-sensitized solar cells (DSCs); however, it has received little attention in DSCs. We consider that the trapping-detrapping-induced variation of the charge collection efficiency might cause J-V hysteresis. Therefore, we conduct a systematic study on the influence of an external bias field during and before J-V measurements in typical DSCs. We find that the J-V performance of DSCs significantly depends on the scan bias direction and the external bias field before and during measurements. Our results indicate that the external-bias-field-modulated charge injection, trapping-detrapping, and accumulation processes in DSCs are possible causes for the anomalous J-V behavior.

  18. Effects of Complex System Structure and External Field in Opinion Formation

    Science.gov (United States)

    Guo, Long; Cai, Xu

    Around us, the society structure and external field, such as government policy, the newspaper, the internet and other mass media, play a special role in shaping the attitudes, beliefs and public opinion. For studying the role of the society structure and the external field, we propose a new opinion model based on the former models. With computer simulations of opinion dynamics, we find that the smaller the clustering coefficient and the society size, the easier the consensus phase is reached and other interesting results.

  19. Effects of external environment on thermocapillary convection of high prandtl number fluid

    Directory of Open Access Journals (Sweden)

    Liang Ruquan

    2016-01-01

    Full Text Available Numerical simulations have been carried out to investigate the influence of external environment on thermocapillary convection in high Prandtl number (Pr=68 liquid. The geometric model of physical problem is that the the liquid bridge surrounded by ambient air under zero or ground gravity. The interface velocity, temperature, heat flux and flow pattern in the liquid bridge are presented and discussed under different conditions by changing the external environment. The buoyancy convection produces a symmetrical vortex in the liquid bridge. The ambient air affects the distributions of the temperature velocity and heat flux on the interface by changing the thermocapillary convection.

  20. Stay Focused! The Effects of Internal and External Focus of Attention on Movement Automaticity in Patients with Stroke.

    Science.gov (United States)

    Kal, E C; van der Kamp, J; Houdijk, H; Groet, E; van Bennekom, C A M; Scherder, E J A

    2015-01-01

    Dual-task performance is often impaired after stroke. This may be resolved by enhancing patients' automaticity of movement. This study sets out to test the constrained action hypothesis, which holds that automaticity of movement is enhanced by triggering an external focus (on movement effects), rather than an internal focus (on movement execution). Thirty-nine individuals with chronic, unilateral stroke performed a one-leg-stepping task with both legs in single- and dual-task conditions. Attentional focus was manipulated with instructions. Motor performance (movement speed), movement automaticity (fluency of movement), and dual-task performance (dual-task costs) were assessed. The effects of focus on movement speed, single- and dual-task movement fluency, and dual-task costs were analysed with generalized estimating equations. Results showed that, overall, single-task performance was unaffected by focus (p = .341). Regarding movement fluency, no main effects of focus were found in single- or dual-task conditions (p's ≥ .13). However, focus by leg interactions suggested that an external focus reduced movement fluency of the paretic leg compared to an internal focus (single-task conditions: p = .068; dual-task conditions: p = .084). An external focus also tended to result in inferior dual-task performance (β = -2.38, p = .065). Finally, a near-significant interaction (β = 2.36, p = .055) suggested that dual-task performance was more constrained by patients' attentional capacity in external focus conditions. We conclude that, compared to an internal focus, an external focus did not result in more automated movements in chronic stroke patients. Contrary to expectations, trends were found for enhanced automaticity with an internal focus. These findings might be due to patients' strong preference to use an internal focus in daily life. Future work needs to establish the more permanent effects of learning with different attentional foci on re-automating motor control

  1. Deeper Insight into the Six-Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products.

    Science.gov (United States)

    Bock, Christina M; Parameshwarappa, Gangajji; Bönisch, Simon; Bauer, Walter; Hutterer, Corina; Leidenberger, Maria; Friedrich, Oliver; Marschall, Manfred; Kappes, Barbara; Görling, Andreas; Tsogoeva, Svetlana B

    2017-06-01

    The straightforward and efficient synthesis of complex aza- and carbobicyclic compounds, which are of importance for medicinal chemistry, is a challenge for modern chemical methodology. An unprecedented metal-free six-step domino reaction of aldehydes with malononitrile was presented in our previous study to provide, in a single operation, these bicyclic nitrogen-containing molecules. Presented here is a deeper investigation of this atom-economical domino process by extending the scope of aldehydes, performing post-modifications of domino products, applying bifunctional organocatalysts and comprehensive NMR studies of selected domino products. The thermodynamic aspects of the overall reaction are also demonstrated using DFT methods in conjunction with a semi-empirical treatment of van der Waals interactions. Furthermore, biological studies of seven highly functionalized and artemisinin-containing domino products against human cytomegalovirus (HCMV) and Plasmodium falciparum 3D7 are presented. Remarkably, in vitro tests against HCMV revealed five domino products to be highly active compounds (EC50 0.071-1.8 μm), outperforming the clinical reference drug ganciclovir (EC50 2.6 μm). Against P. falciparum 3D7, three of the investigated artemisinin-derived domino products (EC50 0.72-1.8 nm) were more potent than the clinical drug chloroquine (EC50 9.1 nm).

  2. Deeper Insight into the Six‐Step Domino Reaction of Aldehydes with Malononitrile and Evaluation of Antiviral and Antimalarial Activities of the Obtained Bicyclic Products

    Science.gov (United States)

    Bock, Christina M.; Parameshwarappa, Gangajji; Bönisch, Simon; Bauer, Walter; Hutterer, Corina; Leidenberger, Maria; Friedrich, Oliver; Marschall, Manfred; Kappes, Barbara; Görling, Andreas

    2017-01-01

    Abstract The straightforward and efficient synthesis of complex aza‐ and carbobicyclic compounds, which are of importance for medicinal chemistry, is a challenge for modern chemical methodology. An unprecedented metal‐free six‐step domino reaction of aldehydes with malononitrile was presented in our previous study to provide, in a single operation, these bicyclic nitrogen‐containing molecules. Presented here is a deeper investigation of this atom‐economical domino process by extending the scope of aldehydes, performing post‐modifications of domino products, applying bifunctional organocatalysts and comprehensive NMR studies of selected domino products. The thermodynamic aspects of the overall reaction are also demonstrated using DFT methods in conjunction with a semi‐empirical treatment of van der Waals interactions. Furthermore, biological studies of seven highly functionalized and artemisinin‐containing domino products against human cytomegalovirus (HCMV) and Plasmodium falciparum 3D7 are presented. Remarkably, in vitro tests against HCMV revealed five domino products to be highly active compounds (EC50 0.071–1.8 μm), outperforming the clinical reference drug ganciclovir (EC50 2.6 μm). Against P. falciparum 3D7, three of the investigated artemisinin‐derived domino products (EC50 0.72–1.8 nm) were more potent than the clinical drug chloroquine (EC50 9.1 nm). PMID:28638769

  3. Effects of external magnetic trap on two dark solitons of a two-component Bose-Einstein condensate

    Institute of Scientific and Technical Information of China (English)

    Hong Li; D. N. Wang

    2008-01-01

    Two dark solitons are considered in a two-component Bose-Einstein condensate with an external magnetic trap, and effects of the trap potential on their dynamics are investigated by the numerical simulation. The results show that the dark solitons attract, collide and repel periodically in two components as time changes, the time period depends strictly on the initial condition and the potential, and there are obvious self-trapping effects on the two dark solitons.

  4. Effect of external pulsation on kinematics of fluid particles in the field of Lamb–Oseen vortex pair

    Indian Academy of Sciences (India)

    S ANANTH PAI; SHALIGRAM TIWARI; T SUNDARARAJAN

    2017-04-01

    The effect of external pulsation on a pair of stationary Lamb–Oseen vortices of equal strength has been analyzed to investigate kinematic behavior of a fluid particle. The assumption of vortices being treated stationary or fixed vortex filaments is valid in a reference frame attached to the vortex system with axes along and perpendicular to the line of their centers. Also, it is assumed that change in core shape and size is much small, with least possibility of core merger. In such situations, periodic particle paths are observed and superposition of pulsation becomes beneficial. In the present work, motion of a representative fluid particle is modeled as a non-linear dynamical system by varying both amplitude and frequency of external pulsation. Effect of external pulsation has been brought out with the help of quantification of deviation from periodic paths by using the concept of total average deviation. Results are presented in terms of particle paths, velocity phase plots, velocity signals and their spectra for varying amplitude and frequency of external pulsation.

  5. Synthesis of manganese oxide nanocrystal by ultrasonic bath: effect of external magnetic field.

    Science.gov (United States)

    Bastami, Tahereh Rohani; Entezari, Mohammad H

    2012-07-01

    A novel technique was used for the synthesis of manganese oxide nanocrystal by applying an external magnetic field (EMF) on the precursor solution before sonication with ultrasonic bath. The results were compared in the presence and absence of EMF. Manganese acetate solution as precursor was circulated by a pump at constant speed (7 rpm, equal to flow rate of 51.5 mL/min) in an EMF with intensity of 0.38 T in two exposure times (t(MF), 2h and 24h). Then, the magnetized solution was irradiated indirectly by ultrasonic bath in basic and neutral media. One experiment was designed for the effect of oxygen atmosphere in the case of magnetic treated solution in neutral medium. The as prepared samples were characterized with X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (HRTEM, TEM), energy-dispersive spectrum (EDS), and superconducting quantum interference device (SQUID) analysis. In neutral medium, the sonication of magnetized solution (t(MF), 24h) led mainly to a mixture of Mn(3)O(4) (hausmannite) and γ-MnOOH (manganite) and sonication of unmagnetized solution led to a pure Mn(3)O(4). In point of particle size, the larger and smaller size of nanoparticles was obtained with and without magnetic treatment, respectively. In addition, the EMF was retarded the nucleation process, accelerated the growth of the crystal, and increased the amount of rod-like structure especially in oxygen atmosphere. In basic medium, a difference was observed on the composition of the products between magnetic treated and untreated solution. For these samples, the magnetic measurements as a function of temperature were exhibited a reduction in ferrimagnetic temperature to T(c)=39K, and 40K with and without magnetic treatment, respectively. The ferrimagnetic temperature was reported for the bulk at T(c)=43K. A superparamagnetic behavior was observed at room temperature without any saturation magnetization and hysteresis in the measured

  6. Perceived environmental uncertainty in Dutch dairy farming: The effect of external farm context on strategic choice

    NARCIS (Netherlands)

    Ondersteijn, C.J.M.; Giesen, G.W.J.; Huirne, R.B.M.

    2006-01-01

    This paper explores the way in which dairy farmers perceive their environment (PE), i.e., the external context of their farm, and the uncertainty (PEU) this poses to them. The environment is defined using the STEP concept (society, technology, economy and politics) and Porter¿s five forces model.

  7. Critical values of the external magnetic field leading biological effects in the human organism

    CERN Document Server

    Kanokov, Zakirjon

    2013-01-01

    In the framework of the simplified stochastic model the critical values of an induction of the external magnetic field leading to sharp increase of fluctuations of a casual current of biologically important ions in different blood vessels of a human body are calculated.

  8. The effect of external dummy transmitters on oxygen consumption and performance of swimming Atlantic cod

    DEFF Research Database (Denmark)

    Steinhausen, M.F.; Andersen, Niels Gerner; Steffensen, J.F.

    2006-01-01

    Decreased critical swimming speed and increased oxygen consumption (Mo-2) was found for externally tagged Atlantic cod Gadus morhua swimming at a high speed of 0 center dot 9 body length (total length, L-Gamma) s(-1). No difference was found in the standard metabolic rate, indicating...

  9. The Effects of Self Set or Externally Set Goals on Learning in an Uncertain Environment

    Science.gov (United States)

    Osman, Magda

    2012-01-01

    Monitoring refers to online awareness and self-evaluation of one's goal-directed actions, while Control refers to the generation and selection of goal-directed actions (Osman, 2010a). The present study examines the extent to which external estimations of performance influence monitoring and control behaviors. To achieve this, a complex dynamic…

  10. Effects of Managers’ Work Motivation and Networking Activity on Their Reported Levels of External Red Tape

    NARCIS (Netherlands)

    Torenvlied, R.; Akkerman, A.

    2012-01-01

    This study brings together two perspectives on managers’ reported levels of red tape. The work motivation perspective explains how managers’ characteristics, such as work engagement (alienation) or commitment, affect their reported levels of red tape. The external control perspective explains how ma

  11. Effects of Managers’ Work Motivation and Networking Activity on Their Reported Levels of External Red Tape

    NARCIS (Netherlands)

    Torenvlied, R.; Akkerman, A.

    2012-01-01

    This study brings together two perspectives on managers’ reported levels of red tape. The work motivation perspective explains how managers’ characteristics, such as work engagement (alienation) or commitment, affect their reported levels of red tape. The external control perspective explains how

  12. Perceived environmental uncertainty in Dutch dairy farming: The effect of external farm context on strategic choice

    NARCIS (Netherlands)

    Ondersteijn, C.J.M.; Giesen, G.W.J.; Huirne, R.B.M.

    2006-01-01

    This paper explores the way in which dairy farmers perceive their environment (PE), i.e., the external context of their farm, and the uncertainty (PEU) this poses to them. The environment is defined using the STEP concept (society, technology, economy and politics) and Porter¿s five forces model. Th

  13. Effect of an External Electric Field on Positronium Formation in Positron Spur

    DEFF Research Database (Denmark)

    Mogensen, O. E.

    1975-01-01

    The decrease of positronium (Ps) formation in condensed matter caused by the presence of an external electric field is discussed in terms of the spur reaction model of Ps formation. The rather few experimental results available are shown to be in good agreement with the predictions of the model...

  14. Effects of Decreasing External Incentives on Higher Education--Reflections from the Case of Taiwan

    Science.gov (United States)

    Lin, Yung-feng

    2016-01-01

    Widened participation in post-compulsory and higher education is generally regarded as a result of the growing recognition of the internal and external benefits of higher education, which are categorised either as a private or public good. However, a question can be raised: once these incentives become less promising or less evident, will a strong…

  15. Perceived environmental uncertainty in Dutch dairy farming: The effect of external farm context on strategic choice

    NARCIS (Netherlands)

    Ondersteijn, C.J.M.; Giesen, G.W.J.; Huirne, R.B.M.

    2006-01-01

    This paper explores the way in which dairy farmers perceive their environment (PE), i.e., the external context of their farm, and the uncertainty (PEU) this poses to them. The environment is defined using the STEP concept (society, technology, economy and politics) and Porter¿s five forces model. Th

  16. Effects of growth conditions on external quality of cut chrysanthemum; analysis and simulation

    NARCIS (Netherlands)

    Carvalho, S.M.P.

    2003-01-01

    For many years the emphasis in floricultural research laid with quantity rather than quality. Nowadays, since the prices are often determined on the basis of visual quality aspects, the so-called external quality, chrysanthemum growers aim to provide a high and constant product qualit

  17. The effect of external boundary conditions on condensation heat transfer in rotating heat pipes

    Science.gov (United States)

    Daniels, T. C.; Williams, R. J.

    1979-01-01

    Experimental evidence shows the importance of external boundary conditions on the overall performance of a rotating heat pipe condenser. Data are presented for the boundary conditions of constant heat flux and constant wall temperature for rotating heat pipes containing either pure vapor or a mixture of vapor and noncondensable gas as working fluid.

  18. The Effects of Parental Depressive Symptoms, Appraisals, and Physical Punishment on Later Child Externalizing Behavior

    Science.gov (United States)

    Callender, Kevin A.; Olson, Sheryl L.; Choe, Daniel E.; Sameroff, Arnold J.

    2012-01-01

    Examined a cognitive-behavioral pathway by which depressive symptoms in mothers and fathers increase risk for later child externalizing problem behavior via parents' appraisals of child behavior and physical discipline. Participants were 245 children (118 girls) at risk for school-age conduct problems, and their parents and teachers. Children were…

  19. Parent Attachment, Childrearing Behavior, and Child Attachment: Mediated Effects Predicting Preschoolers' Externalizing Behavior

    Science.gov (United States)

    Roskam, Isabelle; Meunier, Jean-Christophe; Stievenart, Marie

    2011-01-01

    Attachment theory provides an interesting background for thinking about externalizing behavior (EB) in early childhood and for understanding how parenting influences the child's outcomes. The study examined how attachment and parenting could be combined to explain preschoolers' EB. Data were collected from 117 preschoolers aged from 4 to 6…

  20. EFFECTS OF CARBOXYMETHLY DEXTRAN MAGNETIC NANOPARTICLES CARRIER SYSTEM ASSOCIATED WITH EXTERNAL MAGNETIC FIELDS ON KILLING TUMOR CELLS AND GENE TRANSFECTION

    Institute of Scientific and Technical Information of China (English)

    CAO Zheng-guo; ZHOU Si-wei; LIU Ji-hong

    2005-01-01

    Objective: To investigate the preparation of the carboxymethly dextran iron oxide magnetic nanoparticles (CDMN) and the effects of CDMN carrier system associated with external magnetic fields on killing tumor cells and gene transfection in vitro. Methods: Epirubicin-CDMN (EPI-CDMN) and green fluorescent protein (GFP) plasmid-CDMN (GFP-CDMN) were prepared by the oxidation-reduction procedure and their characters were detected, respectively. The effects of EPI-CDMN associated with external pulsed electromagnetic fields (PEMFs) (10 mT) on killing human bladder cancer BIU-87 cells were studied by MTT assay and Annexin-V/PI double-labeled flow cytometry technique, respectively. And the transfection efficiency of GFP when CDMN were used as gene carrier associated with the external magnetic fields was evaluated under fluorescence microscope in vitro. Results: The diameter of EPI-CDMN and GFP-CDMN were about 8~10 nm and 5~9 nm, respectively, and saturation magnetization were 0.22 emu/g and 0.26 emu/g, respectively. EPI-CDMN associated with PEMFs could significantly inhibit the proliferation of BIU-87 cells and induce cells apoptosis, the growth inhibitory rate and apoptosis rate were (21.82(3.18)% and (16.79(3.37)%, respectively. The transfection efficiency of GFP-CDMN combined with PEMFs was significant higher than that of GFP-CDMN without PEMFs [(45.70(4.32)% vs (35.85(2.16)%, P<0.05]. Conclusion: It seemed that EPI-CDMN associated with external magnetic fields could significantly killed human bladder cancer BIU-87 cells and CDMN could effectively transfer GFP gene into tumors cells with the help of external magnetic fields which provided experimental basis for the magnetic targeting therapy of tumor.

  1. One-pot synthesis of α,β-epoxy ketones through domino reaction between alkenes and aldehydes catalyzed by proline based chiral organocatalysts.

    Science.gov (United States)

    Ashokkumar, Veeramanoharan; Siva, Ayyanar

    2017-03-22

    Proline based metal free organocatalysts were developed by using a new approach for the synthesis of epoxide derivatives through a domino reaction. This domino reaction (oxidative coupling) allows a direct access to epoxides from various alkenes and aldehydes through C-H functionalization and C-C/C-O bond formation. The catalytic efficiencies of the newly synthesized organocatalysts were also determined by domino reaction in the presence of various functional groups containing aldehyde and alkene derivatives with very good yields (up to 95%) and ee's (up to 99%).

  2. Cause or effect of arteriogenesis: compositional alterations of microparticles from CAD patients undergoing external counterpulsation therapy.

    Directory of Open Access Journals (Sweden)

    Ali Al Kaabi

    Full Text Available UNLABELLED: Recently, a clinical study on patients with stable coronary artery disease (CAD showed that external counterpulsation therapy (ECP at high (300 mmHg but not at low inflation pressure (80 mmHg promoted coronary collateral growth, most likely due to shear stress-induced arteriogenesis. The exact molecular mechanisms behind shear stress-induced arteriogenesis are still obscure. We therefore characterized plasma levels of circulating microparticles (MPs from these CAD patients because of their ambivalent nature as a known cardiovascular risk factor and as a promoter of neovascularization in the case of platelet-derived MPs. MPs positive for Annexin V and CD31CD41 were increased, albeit statistically significant (P<0.05, vs. baseline only in patients receiving high inflation pressure ECP as determined by flow cytometry. MPs positive for CD62E, CD146, and CD14 were unaffected. In high, but not in low, inflation pressure treatment, change of CD31CD41 was inversely correlated to the change in collateral flow index (CFI, a measure for collateral growth. MPs from the high inflation pressure group had a more sustained pro-angiogenic effect than the ones from the low inflation pressure group, with the exception of one patient showing also an increased CFI after treatment. A total of 1005 proteins were identified by a label-free proteomics approach from MPs of three patients of each group applying stringent acceptance criteria. Based on semi-quantitative protein abundance measurements, MPs after ECP therapy contained more cellular proteins and increased CD31, corroborating the increase in MPs. Furthermore, we show that MP-associated factors of the innate immune system were decreased, many membrane-associated signaling proteins, and the known arteriogenesis stimulating protein transforming growth factor beta-1 were increased after ECP therapy. In conclusion, our data show that ECP therapy increases platelet-derived MPs in patients with CAD and

  3. Applying "domino" model to study dipolar geomagnetic field reversals and secular variation

    Science.gov (United States)

    Peqini, Klaudio; Duka, Bejo

    2014-05-01

    Aiming to understand the physical processes underneath the reversals events of geomagnetic field, different numerical models have been conceived. We considered the so named "domino" model, an Ising-Heisenberg model of interacting magnetic spins aligned along a ring [Mazaud and Laj, EPSL, 1989; Mori et al., arXiv:1110.5062v2, 2012]. We will present here some results which are slightly different from the already published results, and will give our interpretation on the differences. Following the empirical studies of the long series of the axial magnetic moment (dipolar moment or "magnetization") generated by the model varying all model parameters, we defined the set of parameters that supply the longest mean time between reversals. Using this set of parameters, a short time series (about 10,000 years) of axial magnetic moment was generated. After de-noising the fluctuation of this time series, we compared it with the series of dipolar magnetic moment values supplied by CALS10K.1b model for the last 10000 years. We found similar behavior of the both series, even if the "domino" model could not supply a full explanation of the geomagnetic field SV. In a similar way we will compare a 14000 years long series with the dipolar magnetic moment obtained by the model SHA.DIF.14k [Pavón-Carrasco et al., EPSL, 2014].

  4. Outflow reconstruction with arterial patch in domino liver transplantation:a new technical option

    Institute of Scientific and Technical Information of China (English)

    Laura Lladó; Emilio Ramos; Sofia De LaSerna; Joan Fabregat

    2014-01-01

    Domino liver transplantation (LT), using livers from familial amyloidotic polyneuropathy (FAP) patients, is a well described technique useful to expand donor pool. One of the main difficulties of this type of LT arises from the necessity to share the vascular pedicles between the graft and the donor. The most important challenge resides in restoring a proper hepatic venous outflow in the FAP-liver recipient. This is specially challenging when using the piggy-back technique, because the hepatic stumps may be too short. To overcome this issue, surgeons explored several techniques using different types of venous grafts. We describe a new technical option by using an arterial graft from the deceased donor. By using both iliac arteries a long graft is created and sutured as needed to the hepatic vein stump. We describe herein this new technique employed in a domino liver recipient who underwent retransplantation for ischemic cholangitis. The procedure was performed using the piggy-back technique; the venous stump of the FAP liver was reconstructed with the arterial graft. The patient had uneventful postoperative and mid-term hepatic function, and anastomosis was patent 24 months after LT.

  5. Asymmetric three-component domino reaction: an original access to chiral nonracemic 1,3-thiazin-2-ones.

    Science.gov (United States)

    Peudru, Flavie; Le Cavelier, Fabien; Lohier, Jean-François; Gulea, Mihaela; Reboul, Vincent

    2013-11-15

    A new asymmetric three-component domino process, based on a diastereoselective hetero-Diels-Alder reaction, involving an aldehyde, an alkene, and a chiral thiocarbamate was developed. The chiral auxiliary is directly removed during this process, leading to enantioenriched 2H-1,3-thiazin-2-ones with up to 96% ee.

  6. High speed and leakage-tolerant domino circuits for high fan-in applications in 70nm CMOS technology

    DEFF Research Database (Denmark)

    Moradi, Farshad; Wisland, Dag; Mahmoodi, Hamid;

    with latter proposed circuit. According to simulations in a predictive 70 nm process, the proposed circuit increases noise immunity by more than 26X for wide OR gates and shows performance improvement of up to 20% compared to conventional domino logic circuits. The proposed circuit reduces the contention...

  7. Zirconyl Chloride Promoted Highly Efficient Domino Synthesis of New 1, 2, 3, 4-Tetrahydroquinoline Derivatives in Water

    Institute of Scientific and Technical Information of China (English)

    Rahul R. NAGAWADE; Devanand B. SHINDE

    2006-01-01

    The tetrahydroquinoline moiety is a structural feature of many natural products. By using a domino reaction of aromatic amines and cyclic enol ethers catalyzed by zirconyl chloride in water, various tetrahydroquinoline derivatives were synthesized efficiently. Most cyclized products showed cis selectivity. The cis selectivity was tentatively rationalized due to chelation control in water.

  8. Living donor liver transplantation in maple syrup urine disease - Case series and world's youngest domino liver donor and recipient.

    Science.gov (United States)

    Mohan, N; Karkra, S; Rastogi, A; Vohra, V; Soin, A S

    2016-05-01

    MSUD occurs due to deficiency of enzyme BCKAD required for metabolism of leucine, isoleucine, and valine leading to the accumulation of these and their ketoacids causing acute metabolic decompensation manifesting as encephalopathy or sudden death. The patient requires special protein-restricted diet to survive. As this enzyme is expressed in liver, liver transplantation has been successfully performed as a cure. We report two patients of MSUD who underwent LDLT while their livers were used as a domino graft for other biliary cirrhotic patients. A 22-month-old male child diagnosed as a case of classic MSUD underwent LDLT from an altruistic aunt as donor following which his serum leucine levels normalized on an unrestricted protein diet. His liver was used as a domino graft. A 38-month-old female child with diagnosed MSUD underwent LDLT from a swap donor, and her liver was used as a domino graft. Her DQ improved post-transplant. LDLT from non-heterozygous donors is a cure for classical MSUD. Their livers can be used as domino grafts for non-MSUD cases. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  9. Highly Efficient and Diastereoselective Synthesis of New Pyrazolylpyrrolizine and Pyrazolylpyrrolidine Derivates by a Three-Component Domino Process

    Directory of Open Access Journals (Sweden)

    Jairo Quiroga

    2014-04-01

    Full Text Available Diastereoselective reactions between 4-formylpyrazoles, N-substituted maleimides and glycine derivates led to new series of pyrazolyldipyrrolo [3,4-a:3',4'-f]pyrrolizines and pyrazolylpyrrolo[3,4-c]pyrroles in good yields. The reactions proceeded by a domino process through azomethine ylides formed in situ via a 1,3-dipolar cycloaddition reaction.

  10. High speed and leakage-tolerant domino circuits for high fan-in applications in 70nm CMOS technology

    DEFF Research Database (Denmark)

    Moradi, Farshad; Wisland, Dag; Mahmoodi, Hamid

    with latter proposed circuit. According to simulations in a predictive 70 nm process, the proposed circuit increases noise immunity by more than 26X for wide OR gates and shows performance improvement of up to 20% compared to conventional domino logic circuits. The proposed circuit reduces the contention...

  11. A Gold(I)-Catalyzed Domino Coupling of Alcohols with Allenes Enables the Synthesis of Highly Substituted Indenes.

    Science.gov (United States)

    Preinfalk, Alexander; Misale, Antonio; Maulide, Nuno

    2016-10-04

    The reaction of aryl-substituted allenes with alcohols under gold catalysis led to highly substituted indenes in good yields, with low catalyst loading and under mild conditions. During this domino transformation, two C-C bonds are formed with water as the only byproduct. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  12. Organocatalytic Asymmetric Domino Michael/Henry Reaction of Indolin-3-ones with o-Formyl-β-nitrostyrenes.

    Science.gov (United States)

    Mahajan, Suruchi; Chauhan, Pankaj; Loh, Charles C J; Uzungelis, Server; Raabe, Gerhard; Enders, Dieter

    2015-04-01

    A highly diastereo- and enantioselective domino Michael/Henry reaction of 1-acetylindolin-3-ones with o-formyl-(E)-β-nitrostyrenes catalyzed by low loading of a quinine-derived amine-squaramide provides the corresponding indolin-3-one derivatives bearing four adjacent stereogenic centers in good to high yields and with excellent stereoselectivities.

  13. DOMINO: development of informative molecular markers for phylogenetic and genome-wide population genetic studies in non-model organisms.

    Science.gov (United States)

    Frías-López, Cristina; Sánchez-Herrero, José F; Guirao-Rico, Sara; Mora, Elisa; Arnedo, Miquel A; Sánchez-Gracia, Alejandro; Rozas, Julio

    2016-12-15

    The development of molecular markers is one of the most important challenges in phylogenetic and genome wide population genetics studies, especially in studies with non-model organisms. A highly promising approach for obtaining suitable markers is the utilization of genomic partitioning strategies for the simultaneous discovery and genotyping of a large number of markers. Unfortunately, not all markers obtained from these strategies provide enough information for solving multiple evolutionary questions at a reasonable taxonomic resolution. We have developed Development Of Molecular markers In Non-model Organisms (DOMINO), a bioinformatics tool for informative marker development from both next generation sequencing (NGS) data and pre-computed sequence alignments. The application implements popular NGS tools with new utilities in a highly versatile pipeline specifically designed to discover or select personalized markers at different levels of taxonomic resolution. These markers can be directly used to study the taxa surveyed for their design, utilized for further downstream PCR amplification in a broader set taxonomic scope, or exploited as suitable templates to bait design for target DNA enrichment techniques. We conducted an exhaustive evaluation of the performance of DOMINO via computer simulations and illustrate its utility to find informative markers in an empirical dataset. DOMINO is freely available from www.ub.edu/softevol/domino CONTACT: elsanchez@ub.edu or jrozas@ub.eduSupplementary information: Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  14. A Novel Leakage-tolerant Domino Logic Circuit With Feedback From Footer Transistor In Ultra Deep Submicron CMOS

    DEFF Research Database (Denmark)

    Moradi, Farshad; Peiravi, Ali; Mahmoodi, Hamid

    As the CMOS manufacturing process scales down into the ultra deep sub-micron regime, the leakage current becomes an increasingly more important consideration in VLSI circuit design. In this paper, a high speed and noise immune domino logic circuit is presented which uses the property of the footer...

  15. The effect of competition from open source software on the quality of proprietary software in the presence of network externalities

    Directory of Open Access Journals (Sweden)

    Mingqing Xing

    2015-05-01

    Full Text Available Purpose: A growing number of open source software emerges in many segments of the software market. In addition, software products usually exhibit network externalities. The purpose of this paper is to study the impact of open source software on the quality choices of proprietary software vendors when the market presents positive network externalities. Design/methodology: To analyze how open source software affects the optimal quality of proprietary software, this paper constructs two vertical differentiation models: the basic model considers proprietary software monopolizing the market, and its extended one considers proprietary software competing with open source substitute. Findings: This paper mainly finds that the presence of open source software does not necessarily lead to the quality of proprietary software decreases (or increases. The network externalities and compatibility between open source and proprietary software may change the impact of open source software on the quality of proprietary software and may affect the quality choices of proprietary software vendors. Originality/value: The main contribution of this paper is to examine the effect of open source software on the quality choices for proprietary software vendors in software markets exhibiting positive network externalities.

  16. A domino-rope for evacuation tools from high-rise buildings%高层建筑火灾紧急逃生的DR技术研究

    Institute of Scientific and Technical Information of China (English)

    杨振宏; 汪秀嶂; 高勇; 张旭华; 王祥尧; 梅建恩

    2005-01-01

    随着我国城市建设的迅速发展,城市人口密集,土地昂贵,城市的高层建筑和超高层建筑越来越多,这些高层建筑正朝着现代化、大型化、多功能化的方向发展,由于高层建筑楼层高,功能复杂,设备繁多,一旦发生火灾,火势迅猛,蔓延迅速,易形成立体燃烧,烟雾浓、毒气重,给扑救工作和人员疏散带来了很大的困难,虽然被困人员有多种逃生方法,但逃生难度大,风险也大,容易造成重大的经济损失和人员伤亡事故.Domino-Rope(DR)技术为被困人员紧急逃生提供了一种途径.%With the fast development of the urban construction, high density population, expensive land, more and more high-rise buildings and even skyscrapers stand out in cities. They are mostly up-to-dated, macro-scale operated and multi-functioned. Due to its high-rise floor, complicated function and various facilities, 3-dimensional burning, thick smog and toxic gas pose great threat to people's lives in case of fire. Therefore, evacuation and rescued word may be held up. It may cause a fatally economic loss and heavy casualties as well. Although there are many breaking-loose methods available for people in these buildings, they still face desperate situations and danger. This paper is to offer a more realistic and secure escaping method-Domino-Rope, which is a more effective approach to people trapped in a fire.

  17. Effects of Magnetic Nanoparticles and External Magnetostatic Field on the Bulk Heterojunction Polymer Solar Cells

    Science.gov (United States)

    Wang, Kai; Yi, Chao; Liu, Chang; Hu, Xiaowen; Chuang, Steven; Gong, Xiong

    2015-03-01

    The price of energy to separate tightly bound electron-hole pair (or charge-transfer state) and extract freely movable charges from low-mobility materials represents fundamental losses for many low-cost photovoltaic devices. In bulk heterojunction (BHJ) polymer solar cells (PSCs), approximately 50% of the total efficiency lost among all energy loss pathways is due to the photogenerated charge carrier recombination within PSCs and low charge carrier mobility of disordered organic materials. To address these issues, we introduce magnetic nanoparticles (MNPs) and orientate these MNPS within BHJ composite by an external magnetostatic field. Over 50% enhanced efficiency was observed from BHJ PSCs incorporated with MNPs and an external magnetostatic field alignment when compared to the control BHJ PSCs. The optimization of BHJ thin film morphology, suppression of charge carrier recombination, and enhancement in charge carrier collection result in a greatly increased short-circuit current density and fill factor, as a result, enhanced power conversion efficiency.

  18. Effects of magnetic nanoparticles and external magnetostatic field on the bulk heterojunction polymer solar cells.

    Science.gov (United States)

    Wang, Kai; Yi, Chao; Liu, Chang; Hu, Xiaowen; Chuang, Steven; Gong, Xiong

    2015-03-18

    The price of energy to separate tightly bound electron-hole pair (or charge-transfer state) and extract freely movable charges from low-mobility materials represents fundamental losses for many low-cost photovoltaic devices. In bulk heterojunction (BHJ) polymer solar cells (PSCs), approximately 50% of the total efficiency lost among all energy loss pathways is due to the photogenerated charge carrier recombination within PSCs and low charge carrier mobility of disordered organic materials. To address these issues, we introduce magnetic nanoparticles (MNPs) and orientate these MNPS within BHJ composite by an external magnetostatic field. Over 50% enhanced efficiency was observed from BHJ PSCs incorporated with MNPs and an external magnetostatic field alignment when compared to the control BHJ PSCs. The optimization of BHJ thin film morphology, suppression of charge carrier recombination, and enhancement in charge carrier collection result in a greatly increased short-circuit current density and fill factor, as a result, enhanced power conversion efficiency.

  19. Effect of external magnetic field on the coexistence of SC and AFM in iron based superconductors

    Science.gov (United States)

    Goi, S. K.; Pradhan, B.; Behera, Srikanta; Parida, P. K.; Mishra, R. N.

    2017-03-01

    We have studied the interplay of antiferromagnetism and superconductivity in presence of an applied external magnetic field for the iron based superconductors. For the purpose we have proposed a model Hamiltonian and solved it self-consistently by using the Zubarev's technique of double time Green's function technique. The self-consistent gap equations are solved numerically and interpreted the gap values from the of density of states plots.

  20. Road transport: questions about a durable growth. Do we have to be afraid of the ``external effects``?; Transport routier: questions sur un developpement durable. Faut-il craindre les ``effets externes``?

    Energy Technology Data Exchange (ETDEWEB)

    Salini, P. [Paris-9 Univ., 75 (France)]|[Paris-12 Univ., 94 - Creteil (France)

    1997-12-31

    Pollution, noise, accidents, spoilt landscapes, towns and valleys blocked by road traffic are the negative consequences of the development of transportation systems and mobility. Road transport is considered as highly polluting and highly space and energy consuming. This books takes stock of this burning topic for all responsible and political participants in this sector: what are the `external effects` of transports and their evaluation, what can be learnt from the economic approaches, what can be expected in the future and what are our degrees of freedom. The approach used by the author consists in discussing the main questions using a critical review of recent published works. The four main chapters of this book deal successively with: the `external effects` of transports (nuisances, environmental and financial impact, financial compensations, heritage destruction, arbitration..), the evaluation of the `external effects` and its benefit, and the compatibility between our transportation system and the development of our community (risks, policy, technological solutions..). (J.S.)

  1. Effect of a static external magnetic perturbation on resistive mode stability in tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Fitzpatrick, R. [Univ. of Texas, Austin, TX (United States). Institute for Fusion Studies; Hender, T.C. [Univ. of Texas, Austin, TX (United States). Institute for Fusion Studies]|[Culham Lab., Abingdon (United Kingdom)

    1994-03-01

    The influence of a general static external magnetic perturbation on the stability of resistive modes in a tokamak plasma is examined. There are three main parts to this investigation. Firstly, the vacuum perturbation is expanded as a set of well-behaved toroidal ring functions and is, thereafter, specified by the coefficients of this expansion. Secondly, a dispersion relation is derived for resistive plasma instabilities in the presence of a general external perturbation and finally, this dispersion relation is solved for the amplitudes of the tearing and twisting modes driven in the plasma by a specific perturbation. It is found that the amplitudes of driven tearing and twisting modes are negligible until a certain critical perturbation strength is exceeded. Only tearing modes are driven in low-{beta} plasmas with {epsilon}{beta}{sub p} << 1. However, twisting modes may also be driven if {epsilon}{beta}{sub p}{approx}>1. For error-field perturbations made up of a large number of different poloidal and toroidal harmonics the critical strength to drive locked modes has a {open_quote}staircase{close_quote} variation with edge-q, characterized by strong discontinuities as coupled rational surfaces enter or leave the plasma. For single harmonic perturbations the variation with edge-q is far smoother. Both types of behaviour have been observed experimentally. The critical perturbation strength is found to decrease strongly close to an ideal external kink stability boundary. This is also in agreement with experimental observations.

  2. How effective is external pituitary irradiation for growth hormone-secreting pituitary tumours

    Energy Technology Data Exchange (ETDEWEB)

    Feek, C.M.; McLelland, J.; Seth, J.; Toft, A.D.; Irvine, W.J.; Padfield, P.L.; Edwards, C.R.W. (Western General Hospital, Edinburgh (UK); Royal Infirmary, Edinburgh (UK))

    1984-04-01

    Forty-six patients with GH-secreting pituitary tumours were treated with external pituitary irradiation through two opposed fields to a total dose of 3750 cGy over 15 fractions. Thirty-patients received external radiotherapy as primary treatment; 16 received radiotherapy combined with pituitary surgery. The mean (+- SD) serum GH in the former group was 74.3 +- 74.8 mU/l before treatment, falling by 28% per year over 0-5 years and by 16% per year over 0-20 years. The mean (+- SD) serum GH in the latter group was 265.4 +- 209.3 mU/l before treatment, falling by 76% in the first year-a direct result of surgery-then by 30% per year over 1-5 years and 16% per year over 1-20 years. Progressive failure of normal anterior pituitary function developed by 10 years, with variable loss of gonadotrophin, corticotrophin and thyrotrophin function. The respective figures for patients treated with radiotherapy alone were 47.4, 29.6 and 16.0% and for the combined group 70.2, 53.9 and 38.1%. Whilst external pituitary irradiation appears to reduce serum GH concentrations in patients with GH-secreting pituitary tumours the major disadvantages are the time taken to achieve a cure and the high incidence of hypopituitarism.

  3. Effect of a DC external electric field on the properties of a nonuniform microwave discharge in hydrogen at reduced pressures

    Energy Technology Data Exchange (ETDEWEB)

    Lebedev, Yu. A., E-mail: lebedev@ips.ac.ru; Krashevskaya, G. V.; Tatarinov, A. V.; Titov, A. Yu.; Epshtein, I. L. [Russian Academy of Sciences, Topchiev Institute of Petrochemical Synthesis (Russian Federation)

    2017-01-15

    The effect of a dc external electrical field on the properties of a highly nonuniform electrode microwave discharge in hydrogen at a pressure of 1 Torr was studied using optical emission spectroscopy and selfconsistent two-dimensional simulations. It is shown that the negative voltage applied to the antenna electrode with respect to the grounded chamber increases the discharge radiation intensity, while the positive voltage does not affect the discharge properties. The simulation results agree well with the experimental data.

  4. Effects of Lewis number on coupled heat and mass transfer in a circular tube subjected to external convective heating.

    Science.gov (United States)

    Jiao, Anjun; Zhang, Yuwen; Ma, Hongbin; Critser, John

    2009-03-01

    Heat and mass transfer in a circular tube subject to the boundary condition of the third kind is investigated. The closed form of temperature and concentration distributions, the local Nusselt number based on the total external heat transfer and convective heat transfer inside the tube, as well as the Sherwood number were obtained. The effects of Lewis number and Biot number on heat and mass transfer were investigated.

  5. Acute effects of dynamic stretching exercise on power output during concentric dynamic constant external resistance leg extension

    OpenAIRE

    YAMAGUCHI, TAICHI; Ishii, Kojiro; Yamanaka, Masanori; YASUDA, KAZUNORI

    2007-01-01

    AbstractThe purpose of the present study was to clarify the acute effect of dynamic stretching exercise on muscular performance during concentric dynamic constant external resistance (DCER, formally called isotonic) muscle actions under various loads. Concentric DCER leg extension power outputs were measured in 12 healthy male students after 2 types of pretreatment. The pre- treatments were: (a) dynamic stretching treatment including 2 types of dynamic stretching exercises of leg extensors an...

  6. Nonlinear Dynamic Analysis of Coupled Gear-Rotor-Bearing System with the Effect of Internal and External Excitations

    Institute of Scientific and Technical Information of China (English)

    ZHOU Shihua; SONG Guiqiu; REN Zhaohui; WEN Bangchun

    2016-01-01

    Extensive studies on nonlinear dynamics of gear systems with internal excitation or external excitation respectively have been carried out. However, the nonlinear characteristics of gear systems under combined internal and external excitations are scarcely investigated. An eight-degree-of-freedom(8-DOF) nonlinear spur gear-rotor-bearing model, which contains backlash, transmission error, eccentricity, gravity and input/output torque, is established, and the coupled lateral-torsional vibration characteristics are studied. Based on the equations of motion, the coupled spur gear-rotor-bearing system(SGRBS) is investigated using the Runge-Kutta numerical method, and the effects of rotational speed, error fluctuation and load fluctuation on the dynamic responses are explored. The results show that a diverse range of nonlinear dynamic characteristics such as periodic motion, quasi-periodic motion, chaotic behaviors and impacts exhibited in the system are strongly attributed to the interaction between internal and external excitations. Significantly, the changing rotational speed could effectively control the vibration of the system. Vibration level increases with the increasing error fluctuation. Whereas the load fluctuation has an influence on the nonlinear dynamic characteristics and the increasing excitation force amplitude makes the vibration amplitude increase, the chaotic motion may be restricted. The proposed model and numerical results can be used for diagnosis of faults and vibration control of practical SGRBS.

  7. Nonlinear dynamic analysis of coupled gear-rotor-bearing system with the effect of internal and external excitations

    Science.gov (United States)

    Zhou, Shihua; Song, Guiqiu; Ren, Zhaohui; Wen, Bangchun

    2016-03-01

    Extensive studies on nonlinear dynamics of gear systems with internal excitation or external excitation respectively have been carried out. However, the nonlinear characteristics of gear systems under combined internal and external excitations are scarcely investigated. An eight-degree-of-freedom(8-DOF) nonlinear spur gear-rotor-bearing model, which contains backlash, transmission error, eccentricity, gravity and input/output torque, is established, and the coupled lateral-torsional vibration characteristics are studied. Based on the equations of motion, the coupled spur gear-rotor-bearing system(SGRBS) is investigated using the Runge-Kutta numerical method, and the effects of rotational speed, error fluctuation and load fluctuation on the dynamic responses are explored. The results show that a diverse range of nonlinear dynamic characteristics such as periodic motion, quasi-periodic motion, chaotic behaviors and impacts exhibited in the system are strongly attributed to the interaction between internal and external excitations. Significantly, the changing rotational speed could effectively control the vibration of the system. Vibration level increases with the increasing error fluctuation. Whereas the load fluctuation has an influence on the nonlinear dynamic characteristics and the increasing excitation force amplitude makes the vibration amplitude increase, the chaotic motion may be restricted. The proposed model and numerical results can be used for diagnosis of faults and vibration control of practical SGRBS.

  8. THE EFFECT OF EMOTIONAL INTELLIGENCE TRAINING ON BEHAVIOR PROBLEMS OF BOYS WITH EXTERNALIZED BEHAVIOR DISORDER IN ELEMENTARY SCHOOLS

    Directory of Open Access Journals (Sweden)

    Kosar Moghaddam POUR

    2014-09-01

    Full Text Available The purpose of this study is to investigate the effect of emotional intelligence on the behavior problems of boys with Externalized behavior disorder in Primary Schools. Method: This quasi-experimental study was conducted along with a pre-test, post-test, with a control group and a follow-up test. For sampling, 40 students identified with Externalized behavioral problems through the Teacher Report Form (TRF and the Child Behavior Checklist (CBCL were chosen and randomly divided into two groups (20 in the experimental group and 20 in the control group. The experimental group received emotional intelligence training program in 17 sessions (2 sessions per week, 60 minutes per session and the control group received no training beyond their regular school program. After two months, in order to examine the stability (durability of training effect, the follow-up test was conducted. Finally, the data obtained were analyzed using the statistical method of generalized estimating equations. Results: The results showed that the intervention program had created a significant difference between the scores of the experimental and control group (p<0.001 and the rate of behavioral problems (aggression, rule breaking occurrence has dropped. This was true for the follow-up results too. Conclusions: It can be concluded that Emotional Intelligence Training decreases the behavior problems of boys with Externalized behavior disorder and helps to prevent high occurrence of these problems.

  9. Effects of external phase on D-cycloserine loaded W/O nanocapsules prepared by the interfacial polymerization method.

    Science.gov (United States)

    Musumeci, Teresa; Ventura, Cinzia A; Carbone, Claudia; Pignatello, Rosario; Puglisi, Giovanni

    2011-07-01

    Water in oil (W/O) polybutylcyanoacrylate nanocapsules containing D-cycloserine (D-CS) for intranasal delivery were prepared by the interfacial polymerization method. Different oils, as external phase, for the preparation of the initial W/O miniemulsions were used and their effect on mean size and other physico-chemical properties were evaluated by photon correlation spectroscopy (PCS) and scanning electron microscopy (SEM) analysis. Two probes at different hydrophilicity were used to verify the internal aqueous nature of the core. Both miniemulsions and nanocapsules mean size and polydispersity index were influenced by the used external phase. Different entrapment efficiency were obtained for D-cycloserine-loaded nanocapsules correlated to the used oil [ranging from 39 to 51% encapsulation efficiency (E.E.)]. In vitro drug release showed an initial burst effect (ranging from 20 to 40%) followed by a slow release of D-CS for all preparations. This study demonstrated that many relevant physico-chemical and technological properties of polybutylcyanoacrylate nanocapsules prepared by interfacial polymerization of miniemulsions are significantly influenced by the external oil phase used.

  10. Strain-effect transistors: Theoretical study on the effects of external strain on III-nitride high-electron-mobility transistors on flexible substrates

    Science.gov (United States)

    Shervin, Shahab; Kim, Seung-Hwan; Asadirad, Mojtaba; Ravipati, Srikanth; Lee, Keon-Hwa; Bulashevich, Kirill; Ryou, Jae-Hyun

    2015-11-01

    This paper presents strain-effect transistors (SETs) based on flexible III-nitride high-electron-mobility transistors (HEMTs) through theoretical calculations. We show that the electronic band structures of InAlGaN/GaN thin-film heterostructures on flexible substrates can be modified by external bending with a high degree of freedom using polarization properties of the polar semiconductor materials. Transfer characteristics of the HEMT devices, including threshold voltage and transconductance, are controlled by varied external strain. Equilibrium 2-dimensional electron gas (2DEG) is enhanced with applied tensile strain by bending the flexible structure with the concave-side down (bend-down condition). 2DEG density is reduced and eventually depleted with increasing compressive strain in bend-up conditions. The operation mode of different HEMT structures changes from depletion- to enchantment-mode or vice versa depending on the type and magnitude of external strain. The results suggest that the operation modes and transfer characteristics of HEMTs can be engineered with an optimum external bending strain applied in the device structure, which is expected to be beneficial for both radio frequency and switching applications. In addition, we show that drain currents of transistors based on flexible InAlGaN/GaN can be modulated only by external strain without applying electric field in the gate. The channel conductivity modulation that is obtained by only external strain proposes an extended functional device, gate-free SETs, which can be used in electro-mechanical applications.

  11. Strain-effect transistors: Theoretical study on the effects of external strain on III-nitride high-electron-mobility transistors on flexible substrates

    Energy Technology Data Exchange (ETDEWEB)

    Shervin, Shahab; Asadirad, Mojtaba [Department of Mechanical Engineering, University of Houston, Houston, Texas 77204-4006 (United States); Materials Science and Engineering Program, University of Houston, Houston, Texas 77204 (United States); Kim, Seung-Hwan; Ravipati, Srikanth; Lee, Keon-Hwa [Department of Mechanical Engineering, University of Houston, Houston, Texas 77204-4006 (United States); Bulashevich, Kirill [STR Group, Inc., Engels av. 27, P.O. Box 89, 194156, St. Petersburg (Russian Federation); Ryou, Jae-Hyun, E-mail: jryou@uh.edu [Department of Mechanical Engineering, University of Houston, Houston, Texas 77204-4006 (United States); Materials Science and Engineering Program, University of Houston, Houston, Texas 77204 (United States); Texas Center for Superconductivity at the University of Houston (TcSUH), University of Houston, Houston, Texas 77204 (United States)

    2015-11-09

    This paper presents strain-effect transistors (SETs) based on flexible III-nitride high-electron-mobility transistors (HEMTs) through theoretical calculations. We show that the electronic band structures of InAlGaN/GaN thin-film heterostructures on flexible substrates can be modified by external bending with a high degree of freedom using polarization properties of the polar semiconductor materials. Transfer characteristics of the HEMT devices, including threshold voltage and transconductance, are controlled by varied external strain. Equilibrium 2-dimensional electron gas (2DEG) is enhanced with applied tensile strain by bending the flexible structure with the concave-side down (bend-down condition). 2DEG density is reduced and eventually depleted with increasing compressive strain in bend-up conditions. The operation mode of different HEMT structures changes from depletion- to enchantment-mode or vice versa depending on the type and magnitude of external strain. The results suggest that the operation modes and transfer characteristics of HEMTs can be engineered with an optimum external bending strain applied in the device structure, which is expected to be beneficial for both radio frequency and switching applications. In addition, we show that drain currents of transistors based on flexible InAlGaN/GaN can be modulated only by external strain without applying electric field in the gate. The channel conductivity modulation that is obtained by only external strain proposes an extended functional device, gate-free SETs, which can be used in electro-mechanical applications.

  12. Exploring the effect of external shame on body appreciation among Portuguese young adults: The role of self-compassion.

    Science.gov (United States)

    Marta-Simões, Joana; Ferreira, Cláudia; Mendes, Ana Laura

    2016-12-01

    Studies on body image-related disturbances have recently embraced a fresh and innovative construct: body appreciation. Body appreciation, an aspect of positive body image, defines as the detention of a balanced, affectionate and health-conscious relationship with one's own body's features. Its exploration is considered to be essential to the success of upcoming prevention and intervention programs in the area of body image and eating disorders. The role of shame, although widely studied in negative body image and eating psychopathology, is yet unknown regarding body appreciation. In this line, a main goal of this study was to explore the effect of external shame on body appreciation in a sample of Portuguese young adults. Also, taking into account the similarities between body appreciation and self-compassion, and since self-compassion is known as a powerful tool against the impact of shame on body image-related disturbances, this study also intended to test the role of self-compassion in the relationship between external shame and body appreciation. Results revealed body mass index and external shame as negative correlates, and self-compassion as a positive correlate of body appreciation. Also, path analysis showed that external shame holds a significant effect on body appreciation, both directly and indirectly. Specifically, this analysis revealed that self-compassion acts as a mediator between shame and body appreciation. Present findings seem to support the pertinence of programs to promote an affectionate and healthy relationship with one's own body image, which may benefit from the target of shame and the inclusion of self-compassion practices. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. External forces influence the elastic coupling effects during cargo transport by molecular motors.

    Science.gov (United States)

    Berger, Florian; Keller, Corina; Klumpp, Stefan; Lipowsky, Reinhard

    2015-02-01

    Cellular transport is achieved by the cooperative action of molecular motors which are elastically linked to a common cargo. When the motors pull on the cargo at the same time, they experience fluctuating elastic strain forces induced by the stepping of the other motors. These elastic coupling forces can influence the motors' stepping and unbinding behavior and thereby the ability to transport cargos. Based on a generic single motor description, we introduce a framework that explains the response of two identical molecular motors to a constant external force. In particular, we relate the single motor parameters, the coupling strength and the external load force to the dynamics of the motor pair. We derive four distinct transport regimes and determine how the crossover lines between the regimes depend on the load force. Our description of the overall cargo dynamics takes into account relaxational displacements of the cargo caused by the unbinding of one motor. For large forces and weak elastic coupling these back-shifts dominate the displacements. To develop an intuitive understanding about motor cooperativity during cargo transport, we introduce a time scale for load sharing. This time scale allows us to predict how the regulation of single motor parameters influences the cooperativity. As an example, we show that up-regulating the single motor processivity enhances load sharing of the motor pair.

  14. The External Periodic Influence Effect on the Kinetics of Metals Fragmentationduring the Severe Plastic Deformation

    Directory of Open Access Journals (Sweden)

    A.V. Khomenko

    2015-03-01

    Full Text Available Using the Landau theory of phase transitions, the solids fragmentation during the process of severe plastic deformation is studied. The density of grain boundaries, dislocations and entropy are introduced for describing the defect structures appearing. This allows us to take into account the two channels of energy dissipation (thermal one and defects formation. The phase diagram that establishes the domains of realization of different limiting structures types is obtained. The interaction of several defect types on the formation of limiting structure in terms of internal energy is studied. The formation conditions for two limiting structures are found. They correspond to the mode, in which there is a mixture of different grain sizes. The kinetics of setting in the steady-state values of the defects density is investigated within the scope of the adiabatic approximation, at which the dislocations density change follows the evolution of the grain boundaries density. The external periodic influence is also analyzed. It is shown that frequency and amplitude of external influence change the system behavior.

  15. Achieving external validity in home advantage research: generalizing crowd noise effects

    Directory of Open Access Journals (Sweden)

    Tony D Myers

    2014-06-01

    Full Text Available Different factors have been postulated to explain the home advantage phenomenon in sport. One plausible explanation investigated has been the influence of a partisan home crowd on sports officials’ decisions. Different types of studies have tested the crowd influence hypothesis including purposefully designed experiments. However, while experimental studies investigating crowd influences have high levels of internal validity, they suffer from a lack of external validity; decision-making in a laboratory setting bearing little resemblance to decision-making in live sports settings. This focused review initially considers threats to external validity in applied and theoretical experimental research. Discussing how such threats can be addressed using representative design by focusing on a recently published study that arguably provides the first experimental evidence of the impact of live crowd noise on officials in sport. The findings of this controlled experiment conducted in a real tournament setting offer some confirmation of the validity of laboratory experimental studies in the area. Finally directions for future research and the future conduct of crowd noise studies are discussed.

  16. Effects of External Radiation Fields on Line Emission - Application to Star-forming Regions

    CERN Document Server

    Chatzikos, Marios; Williams, Robin; van Hoof, Peter; Porter, Ryan

    2013-01-01

    A variety of astronomical environments contain clouds irradiated by a combination of isotropic and beamed radiation fields. For example, molecular clouds may be irradiated by the isotropic cosmic microwave background (CMB), as well as by a nearby active galactic nucleus (AGN). These radiation fields excite atoms and molecules and produce emission in different ways. We revisit the escape probability theorem and derive a novel expression that accounts for the presence of external radiation fields. We show that when the field is isotropic the escape probability is reduced relative to that in the absence of external radiation. This is in agreement with previous results obtained under ad hoc assumptions or with the two-level system, but can be applied to complex many-level models of atoms or molecules. This treatment is in the development version of the spectral synthesis code Cloudy. We examine the spectrum of a Spitzer cloud embedded in the local interstellar radiation field, and show that about 60 percent of it...

  17. Effects of External Radiation Fields on Line Emission—Application to Star-forming Regions

    Science.gov (United States)

    Chatzikos, Marios; Ferland, G. J.; Williams, R. J. R.; Porter, Ryan; van Hoof, P. A. M.

    2013-12-01

    A variety of astronomical environments contain clouds irradiated by a combination of isotropic and beamed radiation fields. For example, molecular clouds may be irradiated by the isotropic cosmic microwave background, as well as by a nearby active galactic nucleus. These radiation fields excite atoms and molecules and produce emission in different ways. We revisit the escape probability theorem and derive a novel expression that accounts for the presence of external radiation fields. We show that when the field is isotropic the escape probability is reduced relative to that in the absence of external radiation. This is in agreement with previous results obtained under ad hoc assumptions or with the two-level system, but can be applied to complex many-level models of atoms or molecules. This treatment is in the development version of the spectral synthesis code CLOUDY. We examine the spectrum of a Spitzer cloud embedded in the local interstellar radiation field and show that about 60% of its emission lines are sensitive to background subtraction. We argue that this geometric approach could provide an additional tool toward understanding the complex radiation fields of starburst galaxies.

  18. 构建Lotus Domino的Brower/Web Server模式%Construction of the Lotus Domino Brower / Web Server model

    Institute of Scientific and Technical Information of China (English)

    李金穗

    2008-01-01

    随着企业原来开发lotus Domino/Notes的Client/Server(客户端朋艮务器)模式,改为现今Brower/Web Serv-er(浏览器/服务器)模式及其实际应用,详细讲述企业局域网B/S模式优势以及如何构建Lotus Domino/Notes的B/S运行模式的具体方法.

  19. A Synthetic Route to Chiral 1,4-Disubstituted Tetrahydro-β-Carbolines via Domino Ring-Opening Cyclization of Activated Aziridines with 2-Vinylindoles.

    Science.gov (United States)

    Sayyad, Masthanvali; Wani, Imtiyaz Ahmad; Babu, Raja; Nanaji, Yerramsetti; Ghorai, Manas K

    2017-03-03

    A simple and efficient strategy for the synthesis of various 1,4-disubstituted tetrahydro-β-carbolines with excellent stereoselectivity (de, ee up to >99%) via domino ring opening cyclization (DROC) of activated aziridines with 2-vinylindoles is described. The reaction proceeds through LiClO4-catalyzed Friedel-Crafts-type alkylation of 2-vinylindoles with activated aziridines followed by an intramolecular aza-Michael reaction in a domino fashion.

  20. Synthesis of Benzo[c]silole Derivatives Bearing a Tetrasubstituted Exocyclic C=C Double Bond by Palladium-Catalyzed Domino Reactions.

    Science.gov (United States)

    Wagner, Patrick; Gulea, Mihaela; Suffert, Jean; Donnard, Morgan

    2017-06-01

    The synthesis of diversely substituted 2,3-dihydro-benzo[c]siloles through an unprecedented palladium-catalyzed domino sequence is reported, involving a cyclocarbopalladation of an internal silylalkyne. This reaction proceeds with complete stereoselectivity to lead to a fully substituted exocyclic C=C double bond. Notably, the overall domino sequence appears to be crucial to obtain the desired cyclic vinylsilanes. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Effect of scapular external rotation on the axillary nerve during the arthroscopic Latarjet procedure: an anatomical investigation.

    Science.gov (United States)

    Reinares, Felipe; Werthel, Jean-David; Moraiti, Constantina; Valenti, Philippe

    2016-06-24

    The first purpose of this study is to measure the distance between the axillary nerve and the exit point of K-wires placed retrograde through the glenoid in the setting of an arthroscopic Latarjet procedure. The second objective is to evaluate whether manual external rotation of the scapula alters that distance. In seven fresh-frozen specimens, two 2.0-mm K-wires were drilled through the glenoid using an arthroscopic Latarjet retrograde glenoid guide. These were drilled into the glenoid at the 7- and 8-o'clock positions (right shoulders) and at the 4- and 5-o'clock positions (left). K-wires were oriented parallel to the glenoid articular surface and perpendicular to the long superoinferior axis of the glenoid, 7 mm medial to the joint surface. Two independent evaluators measured the distances between the axillary nerve and the exit point of the K-wires in the horizontal plane (AKHS for the superior K-wire and AKHI for the inferior K-wire) and in the vertical plane (AKV). Measurements were taken with the scapula left free and were repeated with the scapula placed at 15° and 30° of external rotation. With the scapula left free, scapular external rotation was 34° ± 2.3°. In this position, the AKHS was 2.5 ± 1.6, 6.3 ± 1.2 mm at 15° of external rotation (ER) and 11.4 ± 1.4 mm at 30° ER. The AKHI distance was 0.37 ± 1.6, 3.4 ± 1.4 and 10.6 ± 2.1 mm, respectively, for the scapula left free, at 15° ER and 30° of ER. The AKV distances were, respectively, 0.12 ± 0.2, 4.9 ± 1.6 and 9.9 ± 1.7 mm. The increase in all distances was statistically significant (p < 0.001). Increasing scapular external rotation significantly increases the distance between the axillary nerve and the exit point of the K-wires, increasing the margin of safety during this procedure. Therefore, increased external rotation of the scapula could be an effective tool to decrease the risk of iatrogenic axillary nerve injury. Cadaveric study, Level V.

  2. Village sanitation and child health: Effects and external validity in a randomized field experiment in rural India.

    Science.gov (United States)

    Hammer, Jeffrey; Spears, Dean

    2016-07-01

    Over a billion people worldwide defecate in the open, with important consequences for early-life health and human capital accumulation in developing countries. We report a cluster randomized controlled trial of a village sanitation intervention conducted in rural Maharashtra, India designed to identify an effect of village sanitation on average child height, an outcome of increasing importance to economists. We find an effect of approximately 0.3 height-for-age standard deviations, which is consistent with observations and hypotheses in economic and health literatures. We further exploit details of the planning and implementation of the experiment to study treatment heterogeneity and external validity.

  3. Crossing and anti-crossing effects of polaritons in a magnetic-semiconductor superlattice influenced by an external magnetic field

    Science.gov (United States)

    Tuz, Vladimir R.; Fesenko, Volodymyr I.; Fedorin, Illia V.; Sun, Hong-Bo; Shulga, Valeriy M.

    2017-03-01

    Crossing and anti-crossing effects in dispersion characteristics of both bulk and surface polaritons in a magnetic-semiconductor superlattice influenced by an external static magnetic field being in the Faraday geometry are discussed. The bulk polaritons are classified as eigenwaves with right-handed and left-handed elliptically polarized states, whereas the surface polaritons are considered as hybrid modes having a predominant effect of either magnetic or semiconductor subsystem, and distinctions in dispersion characteristics of such polaritons are revealed involving the concept of critical points.

  4. Experimental Evidence for Differential Susceptibility: Dopamine D4 Receptor Polymorphism (DRD4 VNTR) Moderates Intervention Effects on Toddlers' Externalizing Behavior in a Randomized Controlled Trial

    Science.gov (United States)

    Bakermans-Kranenburg, Marian J.; Van Ijzendoorn, Marinus H.; Pijlman, Femke T. A.; Mesman, Judi; Juffer, Femmie

    2008-01-01

    In a randomized controlled trial we tested the role of genetic differences in explaining variability in intervention effects on child externalizing behavior. One hundred fifty-seven families with 1- to 3-year-old children screened for their relatively high levels of externalizing behavior participated in a study implementing Video-feedback…

  5. 基于OS/400的Domino应用平移升级的实现%Migrating and Upgrading Domino Application Based on 0S/400

    Institute of Scientific and Technical Information of China (English)

    宋芬

    2009-01-01

    Lotus Domino is a cross-platform support of the OA system, because of the demand for OA is evolving, hardware and software platform has been replaced by another, and they are bound to be there the issue of migration or upgrade. Based on the Suzhou University OA system upgrade details of translation, on the application of the Domino server from one 0S/400 transplantation to another 0S/400 servers, and application platform to upgrade from Domino B5 to Domino R8 realization process,to later provide some can learn from experience.%Lotus Domino是一个跨平台的OA支持系统.由于对OA的需求是不断发展变化的,硬件和软件平台也在不断更新换代,就必然要出现迁移或者升级的问题.通过对苏州大学OA系统平移升级的详细介绍,阐述了把Domino应用从一台OS/400服务器移植到另一台OS/400服务器,并且把应用平台从Domino R5升级到Domino R8的实现过程.给后来者提供一些可以借鉴的经验.

  6. The effects of external stimuli on molecular organization in organic thin films by infrared spectroscopy

    Science.gov (United States)

    Hietpas, Geoffrey David

    The study of organic thin films has been an active field of research for nearly 100 years. Two general types of organic thin film systems have received considerable attention. The first of these is the field of self-assembled monolayers (SAM's), where a reactive adsorbate is spontaneously organized at a substrate through ionic or covalent bonding. The second area is comprised of thin films of polymeric materials which may also be ordered and chemically attached like SAM's, but also includes disordered systems pinned by random attachment, and purely physisorbed films held by Van der Waals forces. The incentive for research on these systems has focused on potential improvements in applications such as biocompatable implants, lithographic masks or resists, chromatographic coatings, biosensors, and providing corrosion protection for the underlying substrate. For virtually any application, an organic thin film must remain stable such that its structure is either unaltered or reversibly changed in a manner that does not affect performance. In this thesis, the technique of infrared spectroscopy is applied to the study of thin film stability in response to external stimuli. Both polymer thin films (thickness < 0.5 mum) and SAM systems are studied, and chemical as well as mechanical methods of structural perturbation are explored. Taken together, the studies in this thesis demonstrate that organic thin films are fragile systems, often more susceptible to external perturbation than the bulk material. For any thin film system the substrate/film and film/air interfaces as well as the extremely small quantities of film material, all affect the adsorbate material in a manner not present to a significant extent in the bulk state. All of these variables are also potential sources of failure in the film. Therefore, any organic thin film system is sensitive to its immediate surroundings, and an externally applied chemical and mechanical stimuli may 'attack' this structure on several

  7. Diversity oriented combinatorial synthesis of multivalent glycomimetics through a multicomponent domino process.

    Science.gov (United States)

    Bellucci, Maria Cristina; Sani, Monica; Sganappa, Aurora; Volonterio, Alessandro

    2014-12-08

    Both multicomponent reactions and diversity oriented synthesis are indispensable tools for the modern medicinal chemist. However, their employment for the synthesis of multivalent glycomimetics has not been exploited so far although the importance that such compounds play in exploring multivalency on glycoside inhibition. Herein, we report the combinatorial synthesis of diversity oriented hetero di- and trivalent glycomimetics through a multicomponent domino process. The process is high yielding and very general, working efficiently with easily accessible sugar starting materials such as glycosylamines, glycosylazides, and glycosylisothiocyanates, having the reactive functional groups tethered either directly to the anomeric carbon, through a suitable linker, or to the primary 6 position of hexoses (or 5 position of pentoses), leading, in the latter case, to glycomimetics with artificial enzymatically stable backbone. The process has been also exploited for the multicomponent synthesis of aminoglycoside (neomycin) conjugates.

  8. Time and charge calibration of Cherenkov telescope data acquired by Domino Ring Sampler 4 chips

    Energy Technology Data Exchange (ETDEWEB)

    Hoerbe, Mario; Doert, Marlene [Ruhr-Universitaet Bochum (Germany); Bruegge, Kai; Buss, Jens; Bockermann, Christian; Egorov, Alexej [TU Dortmund (Germany)

    2016-07-01

    Very-high-energy gamma-ray astronomy aims to give an insight into the most energetic phenomena in our Universe. Earthbound Cherenkov telescopes can measure Cherenkov light emitted by atmospheric particle showers which are produced by incoming cosmic particles at high energies. Current Cherenkov telescopes, e.g. operated in the FACT and the MAGIC experiments, utilize Domino Ring Sampler 4 (DRS4) chips for recording signals at high speed coming from the telescopes' cameras. DRS4 chips will also be used in the cameras of the Large-Size telescopes of the projected Cherenkov Telescope Array (CTA). We aim at developing a software solution for the calibration of DRS4 data based on the streams-framework, a software tool for streaming analysis which has been developed within the Collaborative Research Center SFB 876. The objectives and the current status of the project are presented.

  9. Domino Reactions Based on Combinatorial Bond Transformations in Electron-Deficient Tertiary Enamines.

    Science.gov (United States)

    Wan, Jie-Ping; Gao, Yong

    2016-06-01

    Electron-deficient enamines such as enaminones and enaminoesters are moieties showing widespread application in organic synthesis. Among the various available electron-deficient enamines, the N,N-disubstituted amino-functionalized ones (tertiary enamines) represent a class of special enamines with distinct properties and important applications. Based on our longstanding interest in exploring novel synthetic methods using electron-deficient tertiary enamines, we present herein the research advances in organic synthesis via domino reactions making use of the combinatorial C-N, C=C, C-H, and other bond transformations of electron-deficient tertiary enamines. © 2016 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Intramolecular Formal anti-Carbopalladation/Heck Reaction: Facile Domino Access to Carbo- and Heterooligocyclic Dienes.

    Science.gov (United States)

    Pawliczek, Martin; Milde, Bastian; Jones, Peter G; Werz, Daniel B

    2015-08-24

    An intramolecular domino process consisting of a formal anti-carbopalladation followed by Heck reaction is realized. Complex oligo(hetero)cyclic scaffolds are efficiently obtained in one synthetic step from easily obtainable enyne precursors. In contrast to common syn-carbopalladation reactions of alkyne units, the carbopalladation employed here is designed to afford an anti-arrangement of the two new substituents across the emerging double bond. A prerequisite is that the residues next to the alkyne should lack any β-hydrogen atoms. The method paves the way to tri- and tetrasubstituted double-bond systems that have not been accessible by conventional Pd catalysis. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Multistep divergent synthesis of benzimidazole linked benzoxazole/benzothiazole via copper catalyzed domino annulation.

    Science.gov (United States)

    Liao, Jen-Yu; Selvaraju, Manikandan; Chen, Chih-Hau; Sun, Chung-Ming

    2013-04-21

    An efficient, facile synthesis of structurally diverse benzimidazole integrated benzoxazole and benzothiazoles has been developed. In a multi-step synthetic sequence, 4-fluoro-3-nitrobenzoic acid was converted into benzimidazole bis-heterocycles, via the intermediacy of benzimidazole linked ortho-chloro amines. The amphiphilic reactivity of this intermediate was designed to achieve the title compounds by the reaction of various acid chlorides and isothiocyanates in a single step through the in situ formation of ortho-chloro anilides and thioureas under microwave irradiation. A versatile one pot domino annulation reaction was developed to involve the reaction of benzimidazole linked ortho-chloro amines with acid chlorides and isothiocyanates. The initial acylation and urea formation followed by copper catalyzed intramolecular C-O and C-S cross coupling reactions furnished the angularly oriented bis-heterocycles which bear a close resemblance to the streptomyces antibiotic UK-1.

  12. Effect of storage at different temperatures on development of external color and quality of pineapple fruits cv. Gold Extra Sweet

    Directory of Open Access Journals (Sweden)

    Luis Ulloa

    2015-11-01

    Full Text Available In order to improve the quality of the fruit, judged at the market as the degree of yellowing of the peel, 2 experiments were performed to evaluate the effect of storage temperature on change in external color of pineapple (Ananas comosus fruit cv. “Gold Extra Sweet”. The temperatures evaluated were 7.5°C; 10.0°C; 12.5°C and 15.0°C, and their effect on the color change and the chlorophyll content in the peel, respiration rate and parameters of external and internal quality were measured. The fruit was stored at different temperatures for 21 days and then transferred to 18.0°C during 4 additional days. At the end of the storage period, pineapples at 7.5°C showed the highest content of chlorophyll a (200 μg.g-1 f.w and the lowest degree of external color (0.32-0.70, fruits stored at 15.0°C had the lowest content of chlorophyll a (40 μg.g-1 f.w and the highest color grade (4.42-5.25. Pineapples stored at 7.5°C showed the lowest respiration rate at 21 days (6.4 ml CO2/kg*h, while fruit stored at 15.0°C had the highest respiration rate (15.8 ml CO2/kg*h. As the storage temperature increased the weight loss and mold growth in the peduncle increased. At the end of storage at 18.0°C, the color advance in the fruits previously stored at 7.5°C was the lowest, while the highest external yellow color developed on the fruits previously kept at 15.0°C. The results suggest that the storage temperature affects chlorophyll degradation and development of external yellow color, which could be useful in the commercial management of pineapple fruit.

  13. Effect of Proportion of Home and External Scrap on the Mechanical Properties of Recycled PVC: A Comparative Study

    Directory of Open Access Journals (Sweden)

    M. Jalal Uddin

    2015-06-01

    Full Text Available Raw material powder mixtures have been prepared with PVC resin, unplasticized polyvinylchloride (uPVC scrap and additives. A twin screw extruder has been used to make pipe for sample preparation from the mixture. Domestic and external uPVC scrap were formulated and blended with PVC resin to form melt compound. Domestic samples designated as DS-10, DS-20, DS-30, DS-40, DS-50 and DS-100 have been prepared by blending 10, 20, 30, 40, and 50 phr and 100% uPVC domestic scrap with PVC resin and various additives, followed by extrusion, flattening and machining. Following a similar procedure, external samples such as ES-10, ES-20, ES-30, ES-40, ES-50 and ES-100 have been prepared using external uPVC scrap. The effects of the proportions of uPVC scrap in the raw material mix on the mechanical properties such as break stress (BS, % elongation at break, flexural yield strength [1], impact strength (IS and Shore hardness were investigated. The maximum decrease in break stress is 11.40% for 20 phr domestic scrap, while in samples containing external scrap this decrease is 15.71% for 40 phr scrap. The minimum and maximum reduction in IS values of DS are recorded 1.0% for DS-10 and 27.4% for DS-40, respectively, whereas the minimum and maximum decrease in IS values of ES recorded are 9.6% for ES-10 and 39.2% for ES-50, respectively. The minimum and maximum increase in hardness values of DS are recorded as 0.07% for DS-40 and 2.8% for DS-10, respectively, whereas the minimum and maximum reduction in hardness values of ES are recorded as 1.2% for ES-50 and 2.2% for ES-20, respectively. The mechanical properties of samples were found to deteriorate with increasing quantity of scrap in the raw material mix, the effects of external scrap being more prominent.

  14. Understanding the domino reaction between 3-chloroindoles and methyl coumalate yielding carbazoles. A DFT study.

    Science.gov (United States)

    Domingo, Luis R; Sáez, José A; Emamian, Saeed R

    2015-02-21

    The molecular mechanism of the reaction between N-methyl-3-chloroindole and methyl coumalate yielding carbazole has been studied using DFT methods at the MPWB1K/6-311G(d,p) level in toluene. This reaction is a domino process that comprises three consecutive reactions: (i) a polar Diels-Alder (P-DA) reaction between indole and methyl coumalate yielding two stereoisomeric [2 + 4] cycloadducts (CAs); (ii) the elimination of HCl from these CAs affording two stereoisomeric intermediates; and (iii) the extrusion of CO2 in these intermediates, finally yielding the carbazole. This P-DA reaction proceeds in a completely regioselective and slightly exo selective fashion. In spite of the highly polar character of this P-DA reaction, it presents a high activation enthalpy of 21.8 kcal mol(-1) due to the loss of the aromatic character of the indole during the C-C bond formation. Thermodynamic calculations suggest that the P-DA reaction is the rate-determining step of this domino reaction; in addition, the initial HCl elimination in the formal [2 + 4] CAs is kinetically favoured over the extrusion of CO2. Although the P-DA reaction is kinetically and thermodynamically very unfavourable, the easier HCl and CO2 elimination from the [2 + 4] CAs together with the strong exergonic character of the CO2 extrusion makes the P-DA reaction irreversible. An ELF topological analysis of the bonding changes along the P-DA reaction supports a two-stage one-step mechanism. An analysis of the global DFT reactivity indices at the ground state of the reagents confirms the highly polar character of this P-DA reaction. Finally, the complete regioselectivity of the studied reactions can be explained using the Parr functions.

  15. Effects of External Chemical Regulation on Bt Transgenic Cotton Plants under Combined Stress of High Temperature and Water Deficit

    Institute of Scientific and Technical Information of China (English)

    ZHOU Gui-sheng; ZHANG Wang-ding; TONG Chen; LIN Yan; AN Lin-lin; LIU Gui-juan

    2011-01-01

    [Objective] The study aimed to find a possible way to combat or alleviate the negative effects caused by high temperature and water deficit at the growth stage of peak boll-setting.[Method] With Bt transgenic cotton GK22 as the test cultivar,a potted experiment was carried out to investigate the effects of the regulation of external substances(the water solutions of pix,urea and their mixture) on the physiological parameters,insecticidal protein content,yield and yield component of cotton plants in artificial climate chambers treated with high temperature and water deficit.[Result] The application of external pix,urea or their mixture was effective in stabilizing the physiological parameters of cotton plants,insecticidal protein content,yield and yield components.Compared with the exclusive application of pix and urea,the mixture of pix and urea played the most effective role in stabilizing the content of chlorophyll,soluble sugar and insecticidal protein,alleviating the increase of the content of free amino acids and proline,and increasing boll number per plant,boll weight and seed cotton yield.[Conclusion] The water solutions of pix,urea or their mixtures can be used to combat or alleviate the stress of high temperature and water deficit if they are sprayed onto cotton plants prior to stress occurrence.

  16. Effects of external and gap mean flows on sound transmission through a double-wall sandwich panel

    Science.gov (United States)

    Liu, Yu; Sebastian, Alexis

    2015-05-01

    This paper studies analytically the effects of an external mean flow and an internal gap mean flow on sound transmission through a double-wall sandwich panel lined with poroelastic materials. Biot's theory is employed to describe wave propagation in poroelastic materials, and the transfer matrix method with three types of boundary conditions is applied to solve the system simultaneously. The random incidence transmission loss in a diffuse field is calculated numerically, and the limiting angle of incidence due to total internal reflection is discussed in detail. The numerical predictions suggest that the sound insulation performance of such a double-wall panel is enhanced considerably by both external and gap mean flows particularly in the high-frequency range. Similar effects on transmission loss are observed for the two mean flows. It is shown that the effect of the gap mean flow depends on flow velocity, flow direction, gap depth and fluid properties and also that the fluid properties within the gap appear to influence the transmission loss more effectively than the gap flow. Despite the implementation difficulty in practice, an internal gap flow provides more design space for tuning the sound insulation performance of a double-wall sandwich panel and has great potential for active/passive noise control.

  17. Multiple-city e Smart-city. OPEN-DOMINO nei territori marginali e interrotti dell’estremo sud / Multiple-city and smart-city. OPEN-DOMINO in the marginal and interrupted areas of the far south

    Directory of Open Access Journals (Sweden)

    Marina Tornatora

    2015-07-01

    Full Text Available Il patrimonio edilizio esistente oggi è inadeguato alle esigenze della contemporaneità e pone all’architettura la necessità di sperimentare modalità d’intervento, implementate dalle nuove tecnologie ma all’interno dei propri strumenti espressivi e del proprio universo tecnico costruttivo. Un’esperienza didattica su un quartiere marginale della periferia meridionale, preso come campione emblematico, è l’occasione per rielaborare il modello base ricorrente - Maison Domino - come un sistema aperto. / Today The existing building is inadequate to contemporary needs and this raises to architecture the need to experiment with methods of intervention, implemented by new technologies but within its own universe of expressive tools and technical constructive. Teaching experience on a marginal neighborhood of the southern suburbs, taken as a typical example, is an opportunity to rework the model recurring basis - Maison Domino - as an open system.

  18. Total heat loss coefficient of flat roof constructions with external insulation in tapered layers including the effects of thermal bridges

    DEFF Research Database (Denmark)

    Rose, Jørgen; Svendsen, Svend

    2005-01-01

    be quite tedious, and therefore a method to generate and optimize solutions has been developed and implemented in a program that also takes into account the effects of different types of thermal bridges, i.e. roof windows, insulation fasteners, roof/wall joints etc. This paper describes a new method...... for design of flat roofs and a pc-program that can be used for calculating the total heat loss coefficient of externally insulated roofs with insulation in tapered layers, taking into account thermal bridges in the roof construction....

  19. Effects of external fields on a two-dimensional Klein-Gordon particle under pseudo-harmonic oscillator interaction

    Institute of Scientific and Technical Information of China (English)

    Sameer M.Ikhdair; Majid Hamzavi

    2012-01-01

    We study the effects of the perpendicular magnetic and Aharonov Bohm (AB) flux fields on the energy levels of a two-dimensional (2D) Klein-Gordon (KG) particle subjected to an equal scalar and vector pseudo-harmonic oscillator (PHO).We calculate the exact energy eigenvalues and normalized wave functions in terms of chemical potential parameter,magnetic field strength,AB flux field,and magnetic quantum number by means of the Nikiforov-Uvarov (NU) method.The non-relativistic limit,PHO,and harmonic oscillator solutions in the existence and absence of external fields are also obtained.

  20. Effect of wing aspect ratio and flap span on aerodynamic characteristics of an externally blown jet-flap STOL model

    Science.gov (United States)

    Smith, C. C., Jr.

    1973-01-01

    An investigation has been conducted to determine the effects of flap span and wing aspect ratio on the static longitudinal aerodynamic characteristics and chordwise and spanwise pressure distributions on the wing and trailing-edge flap of a straight-wing STOL model having an externally blown jet flap without vertical and horizontal tail surfaces. The force tests were made over an angle-of-attack range for several thrust coefficients and two flap deflections. The pressure data are presented as tabulated and plotted chordwise pressure-distribution coefficients for angles of attack of 1 and 16. Pressure-distribution measurements were made at several spanwise stations.

  1. The effect of external marking on the behaviour of the common pill woodlouse Armadillidium vulgare

    Directory of Open Access Journals (Sweden)

    Táňa Drahokoupilová

    2012-03-01

    Full Text Available Zoologists distinguish individual animals using marking techniques. Generally they test the potential influence of marking on survival only; the influence on behaviour is usually neglected. We evaluated the influence of two external marking techniques (nail polish and queen-bee marker on the behaviour of common pill woodlouse, Armadillidium vulgare. The behaviour was examined from two points of view: (1 activity during 24 hours and (2 specific expressions of behaviour (exploring, feeding, resting and hiding over a 24 hour period. We compared behaviour among woodlice marked with nail polish and queen-bee marker with the unmarked control group during a nine-day experiment. Although we did not find any influence of marking on survival, there was an evident influence on behaviour in most cases. Generally, in the groups of marked individuals of A. vulgare there were large differences observed against the control group in the overall activity. Activity of marked individuals was significantly reduced and they preferred hiding. The influence of polish and marker on the overall frequencies of behavioural categories was evident, mainly in feeding, resting and hiding. The influence on the frequency of exploring was significant in the polish marked group only.

  2. Effect of an external electric field on the propagation velocity of premixed flames

    KAUST Repository

    Sánchez-Sanz, Mario

    2015-01-01

    © 2014 The Combustion Institute. Published by Elsevier Inc. All rights reserved. There have been many experimental investigations into the ability of electric fields to enhance combustion by acting upon ion species present in flames [1]. In this work, we examine this phenomenon using a one-dimensional model of a lean premixed flame under the influence of a longitudinal electric field. We expand upon prior two-step chain-branching reaction laminar models with reactions to model the creation and consumption of both a positively-charged radical species and free electrons. Also included are the electromotive force in the conservation equation for ion species and the electrostatic form of the Maxwell equations in order to resolve ion transport by externally applied and internally induced electric fields. The numerical solution of these equations allows us to compute changes in flame speed due to electric fields. Further, the variation of key kinetic and transport parameters modifies the electrical sensitivity of the flame. From changes in flame speed and reactant profiles we are able to gain novel, valuable insight into how and why combustion can be controlled by electric fields.

  3. Electrotonic potentials in Aloe vera L.: Effects of intercellular and external electrodes arrangement.

    Science.gov (United States)

    Volkov, Alexander G; Nyasani, Eunice K; Tuckett, Clayton; Scott, Jessenia M; Jackson, Mariah M Z; Greeman, Esther A; Greenidge, Ariane S; Cohen, Devin O; Volkova, Maia I; Shtessel, Yuri B

    2017-02-01

    Electrostimulation of plants can induce plant movements, activation of ion channels, ion transport, gene expression, enzymatic systems activation, electrical signaling, plant-cell damage, enhanced wound healing, and influence plant growth. Here we found that electrical networks in plant tissues have electrical differentiators. The amplitude of electrical responses decreases along a leaf and increases by decreasing the distance between polarizing Pt-electrodes. Intercellular Ag/AgCl electrodes inserted in a leaf and extracellular Ag/AgCl electrodes attached to the leaf surface were used to detect the electrotonic potential propagation along a leaf of Aloe vera. There is a difference in duration and amplitude of electrical potentials measured by electrodes inserted in a leaf and those attached to a leaf's surface. If the external reference electrode is located in the soil near the root, it changes the amplitude and duration of electrotonic potentials due to existence of additional resistance, capacitance, ion channels and ion pumps in the root. The information gained from this study can be used to elucidate extracellular and intercellular communication in the form of electrical signals within plants.

  4. Analysis techniques and performance of the Domino Ring Sampler version 4 based readout for the MAGIC telescopes

    Energy Technology Data Exchange (ETDEWEB)

    Sitarek, Julian, E-mail: dzuleq@gmail.com [IFAE, Edifici Cn., Campus UAB, E-08193 Bellaterra (Spain); Gaug, Markus, E-mail: Markus.Gaug@uab.cat [Física de les Radiacions, Departament de Física, Universitat Autònoma de Barcelona, 08193 Bellaterra (Spain); CERES, Universitat Autònoma de Barcelona-IEEC, 08193 Bellaterra (Spain); Mazin, Daniel, E-mail: mazin@mpp.mpg.de [Max-Planck-Institut für Physik, D-80805 München (Germany); Paoletti, Riccardo, E-mail: paoletti@pi.infn.it [Università di Siena, and INFN Pisa, I-53100 Siena (Italy); Tescaro, Diego, E-mail: diegot@ifae.es [Inst. de Astrofísica de Canarias, E-38200 La Laguna, Tenerife (Spain)

    2013-09-21

    Recently the readout of the MAGIC telescopes has been upgraded to a new system based on the Domino Ring Sampler version 4 chip. We present the analysis techniques and the signal extraction performance studies of this system. We study the behavior of the baseline, the noise, the cross-talk, the linearity and the time resolution. We investigate also the optimal signal extraction. In addition we show some of the analysis techniques specific to the readout based on the Domino Ring Sampler version 2 chip, previously used in the MAGIC II telescope. -- Highlights: • We perform studies of the DRS4 based readout of the MAGIC telescopes • Advanced pedestal subtraction procedure results in a stable baseline. • The noise of the system is below one photoelectron. • The calibration of the DRS4 time response gives time resolution of 0.2 ns. • Linearity is very good up to saturation at 750 phe.

  5. One-pot organocatalytic enantioselective Michael/Povarov domino strategy for the construction of spirooctahydroacridine-3,3'-oxindole scaffolds.

    Science.gov (United States)

    Wu, Hao; Wang, Yong-Mei

    2014-05-12

    An asymmetric organocatalytic one-pot strategy for the construction of spirooctahydroacridine-3,3'-oxindole scaffolds has been successfully developed by means of a domino Michael/Povarov reaction sequence. The one-pot protocol affords the chiral spirocyclohexaneoxindoles bearing an octahydroacridine motif with five stereocenters in good to high yields (up to 89 % yield) with excellent to perfect diastereoselectivities (up to >20:1 d.r.) and enantioselectivities (up to >99 % ee). This highly efficient one-pot domino procedure will allow diversity-oriented syntheses of this intriguing class of compounds with potential biological activities. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  6. A new vinyl selenone-based domino approach to spirocyclopropyl oxindoles endowed with anti-HIV RT activity.

    Science.gov (United States)

    Palomba, M; Rossi, L; Sancineto, L; Tramontano, E; Corona, A; Bagnoli, L; Santi, C; Pannecouque, C; Tabarrini, O; Marini, F

    2016-02-14

    Herein, we disclose a general and flexible access to spirocyclopropyl oxindoles by a domino Michael/intramolecular nucleophilic substitution pathway with variously substituted vinyl selenones and enolizable oxindoles in aqueous sodium hydroxide solution. The spirocyclopropyl oxindole being a privileged scaffold, some of the synthesized compounds were selected for biological evaluation. Compound showed selective anti-HIV-1 activity thanks to its ability to inhibit the reverse transcriptase.

  7. SSL Security Technology Research in Lotus Domino%Lotus Domino中的SSL安全技术研究

    Institute of Scientific and Technical Information of China (English)

    周艳; 金炜东

    2002-01-01

    Domino/Notes运用了较新的安全技术,具有较为完善的安全机制.本文就Lotus Domino中的SSL服务进行研究分析,并介绍了如何建立Domino验证字权威,最后通过实例探讨应用中的技巧.

  8. Regio- and stereoselective synthesis of benzothiazolo-pyrimidinones via an NHC-catalyzed Mannich/lactamization domino reaction.

    Science.gov (United States)

    Ni, Qijian; Song, Xiaoxiao; Xiong, Jiawen; Raabe, Gerhard; Enders, Dieter

    2015-01-25

    An NHC-catalyzed regio- and stereoselective Mannich/lactamization domino reaction of N-(benzothiazolyl)imines with α-chloroaldehydes has been developed. This new protocol provides a facile approach for the asymmetric synthesis of benzothiazolo-pyrimidinones and a pyrrolo[1,2-a]indolone in moderate to good yields (34-78%) and excellent stereoselectivities (87-99% ee, up to >20 : 1 d.r.).

  9. Asymmetric synthesis of functionalized trifluoromethyl-substituted pyrrolidines via an organocatalytic domino Michael/Mannich [3+2] cycloaddition.

    Science.gov (United States)

    Zhi, Ying; Zhao, Kun; Liu, Qiang; Wang, Ai; Enders, Dieter

    2016-11-29

    The asymmetric synthesis of highly functionalized pyrrolidine derivatives with three contiguous stereogenic centers and bearing a trifluoromethyl group has been developed through an organocatalytic domino Michael/Mannich [3+2] cycloaddition sequence. Employing a commercially available secondary amine as the catalyst, the scalable one-pot protocol occurs with high yields and excellent stereoselectivities, providing a short entry into a series of trifluoromethylated pyrrolidines with potential medical value.

  10. Radical cation salts induced domino reaction of anilines with enol ethers: Synthesis of 1,2,3,4-tetrahydroquinoline derivatives

    Institute of Scientific and Technical Information of China (English)

    Xiao Dong Jia; Yan Ren; Cong Dde Huo; Wen Juan Wang; Xiang Ning Chen; Qiong Fu; Xi Cun Wang

    2011-01-01

    A domino reaction of anilines with cyclic and acyclic enol ethers induced by catalytic amounts of TBPA+ (5 mol%) was investigated and a series of 2,4-disubstituted-1,2,3,4-tetrahydroquinolines were synthesized. Different from cyclic enol ethers, when acyclic enol ethers were used in the reaction, they serve as surrogates of acetaldehyde, producing a series of 2-methyl-4-anilino-1,2,3,4-tetrahydroquinolines. A single electron transfer mechanism was proposed to rationalize the products formation.

  11. Stereoselective synthesis of 1,3-anti diols by an Ipc-mediated domino aldol-coupling/reduction sequence.

    Science.gov (United States)

    Dieckmann, Michael; Menche, Dirk

    2013-01-04

    A novel domino process for 1,3-anti diol synthesis by the union of a methyl ketone with an aldehyde is described. The operationally simple procedure is based on an Ipc-boron-aldol coupling and subsequent Ipc-mediated reduction of the intermediate β-hydroxy-ketone. The sequence proceeds with excellent anti-selectivities and enables the rapid construction of complex polyketide fragments.

  12. Pd(0)-catalyzed intramolecular α-arylation of sulfones: domino reactions in the synthesis of functionalized tetrahydroisoquinolines.

    Science.gov (United States)

    Solé, Daniel; Pérez-Janer, Ferran; Mancuso, Raffaella

    2015-03-16

    A new strategy for the synthesis of tetrahydroisoquinolines based on the Pd(0)-catalyzed intramolecular α-arylation of sulfones is reported. The combination of this Pd-catalyzed reaction with intermolecular Michael and aza-Michael reactions allows the development of two- and three-step domino processes to synthesize diversely functionalized scaffolds from readily available starting materials. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Polyelectrolyte Multilayer Film Coated Silver Nanorods: An Effective Carrier System for Externally Activated Drug Delivery

    Science.gov (United States)

    Paramasivam, Gokul; Sharma, Varsha; Sundaramurthy, Anandhakumar

    2017-08-01

    Nanoparticle anisotropy offers unique functions and features in comparison with spherical nanoparticles (NPs) and makes anisotropic nanoparticles (ANPs) promising candidates in applications like drug delivery, imaging, biosensing and theranostics. Presence of surface active groups (e.g. amine, and carboxylate groups) on their surface provides binding sites for ligands or other biomolecules, and hence, this could be targeted for specific part or cells in our body. In the quest of such surface modification, functionalization of ANPs along Layer-by-Layer (LbL) coating of oppositely charged polyelectrolytes (PE) reduces cellular toxicity and promotes easy encapsulation of drugs. In this work, we report the silver nanorods (AgNRs) synthesis by adsorbate directed synthetic approach using cetyltrimethyl ammonium bromide (CTAB). The formed ANPs is investigated by scanning electron microscopy (SEM) and UV-Visible (UV-Vis) spectroscopy revealing the shaping of AgNRs of 3-16 nm aspect ratio with some presence of triangles. These NRs were further coated with bio polymers of chitosan (CH) and dextran sulphate (DS) through LbL approach and used for encapsulation of water soluble anti-bacterial drugs like ciprofloxacin hydrochloride (CFH). The encapsulation of drugs and profiles of drug release were investigated and compared to that of spherical silver nanoparticles (AgNPs). The added advantages of the proposed drug delivery system (DDS) can be externally activated to release the loaded drug and used as contrast agents for biological imaging under exposure to NIR light. Such system shows unique and attractive characteristics required for drug delivery and bioimaging thus offering the scope for further development as theranostic material.

  14. Investigation on effect of Fructus Evodiae external application%吴茱萸外用功效的探讨

    Institute of Scientific and Technical Information of China (English)

    崔瑛; 纪彬; 赵素霞; 苗明三

    2011-01-01

    Objective: To investigate the effect of Fructus Evodiae external application. Methods: It was analysised and demonstrated through the literature study. Results: Fructus Evodiae external application includes treating the upper part diseases of the human body, such as sore throat, aphtha, salivation, mumps, infectious swollen head and so on; and the disease of pathogenesis inversing up, such as hypertension, laryngeal stridor. The nature of the most diseases is heat syndrome, such as sore throat,pharyngitis and the infection with swollen head. The methods of treatment on the disease is to cure the down due to the disorder of the up,which is the external application on the center of the foot. Conclusion: Fructus Evodiae external application that treating the upper part and heat syndrome of the human body is related to its bitter taste. The bitter taste of Fructus Evodiae is good at dropping inverse gas and expelling flatulence,because the upper hot syndrome can be taken fire downto reducing pathogenic fire of the effect.%目的:探讨吴茱萸外用的功效.方法:通过文献研究进行分析论证.结果:吴茱萸外用治疗人体上部的疾病,如咽痛、口疮、流涎、痄腮、大头瘟等;治疗病机逆上的病证,如高血压、喉喘鸣;所治疾病性质多属热证,如咽痛、喉痹、大头瘟等.治法上采用上病取下方法,足心外敷给药.结论:吴茱萸外用治疗上部疾病、火热病证与其苦味有关.吴茱萸味苦善降逆气、下气,对于上部火热病证可以引火下行,有降火之功效.

  15. The Effect of External Apple Vinegar Application on Varicosity Symptoms, Pain, and Social Appearance Anxiety: A Randomized Controlled Trial

    Directory of Open Access Journals (Sweden)

    Derya Atik

    2016-01-01

    Full Text Available Aim. We aimed to determine the effect of external apple vinegar application on the symptoms and social appearance anxiety of varicosity patients who were suggested conservative treatment. Method. The study was planned as an experimental, randomized, and controlled study. 120 patients were randomly selected and then were randomly allocated to either experimental or control group by simple blind random sampling method. In the collection of research data, a questionnaire questioning sociodemographic and clinical characteristics, the Visual Analog Scale (VAS for pain, and the Social Appearance Anxiety Scale (SAAS were used. The patients in the study group were suggested to apply apple vinegar to the area of the leg with varicosity alongside the treatment suggested by the doctor. The patients in the control group received no intervention during the study. Results. The sociodemographic and clinic characteristics of both groups were found to be similar (p>0.05. The patients were evaluated with regard to cramps, pain, leg fatigue perception, edema, itching, pigmentation, and weight feelings in the leg, VAS, and SAAS averages in the second evaluation; the control group had a decrease in such symptoms (p>0.05 although the decrease in the application group was higher and statistically meaningful (p<0.05. Conclusion. We determined that the external application of apple vinegar on varicosity patients, which is a very easy application, increased the positive effects of conservative treatment.

  16. Effect of External Quality Assurance Evaluation for Chest Radiography: 3-Year Follow-Up in the Medical Institution for Pneumoconiosis

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Won Jeong; Choi, Soon Byung [Clinical Research Team, Occupational Lung Diseases Institute, Korea Worker' s Compensation and Welfare Service, Ansan (Korea, Republic of)

    2012-04-15

    The aim of this study was to determine the effect of external quality assurance (QA) evaluation for chest radiography in the medical institution for pneumoconiosis (MIP). The chest radiography of the MIPs were evaluated for a radiological technique (RT), image quality (IQ), and reading environment (RE), during a 3-year follow up according to the Korean guidelines. Same methods were implemented each year to ensure that the results are reliable. RT, IQ, and RE were compared between examination and medical care (EMP), and only medical care (MCP) for pneumoconiosis, film-screen (FSR) and digital (DR) radiography. Uneducated and educated for QA during a 3-year follow up referencing with 2008 were realized. RT and IQ of the MIPs showed a significantly higher score in 2009 and 2010 compared with 2008 (p < 0.01). However, RE was not significantly improved. The score of RT, IQ, and RE of the EMPs were higher than those of MCPs every year, and FSR showed a lower score in all evaluations, although, more improvement was seen than the DR. The chest radiography of the MIPs showed a significant effect as a result of a repeated external QA evaluation. However, the MIPs need to transfer from FSR to DR, and maintain a continuous QA evaluation for the MCPs.

  17. Effect of external electric fields on the dielectronic recombination cross section of lithium and sodium like ions

    Energy Technology Data Exchange (ETDEWEB)

    Griffin, D.C.; Pindzola, M.S.; Bottcher, C.

    1985-03-01

    The effect of external electric fields on the dielectronic recombination cross section associated with the 2s ..-->.. 2p excitation in the Li like ions B/sup 2 +/, C/sup 3 +/, O/sup 5 +/, and Fe/sup 23 +/, and the 3s ..-->.. 3p excitation in the Na like ions Mg/sup +/, S/sup 5 +/, Cl/sup 6 +/, and Fe/sup 15 +/ has been studied in the configuration-average, distorted-wave approximation. By applying the linear-Stark approximation to the doubly-excited 2pnl and 3pnl Rydberg states in the presence of an external electric field, we study the systematics of field mixing effects on dielectronic recombination and determine the maximum field enhancement of the dielectronic recombination cross section. We find that the magnitude of the field enhancement decreases as we move up an isoelectronic sequence and is of the order of a factor of two or three in highly-ionized systems. In addition, we show that dielectronic recombination transitions through doubly-excited states near threshold can produce large narrow peaks in the cross section at low energies, which are especially prominent in high stages of ionization, and are not affected by the electric field.

  18. Domino Michael-Michael and Aldol-Aldol Reactions: Diastereoselective Synthesis of Functionalized Cyclohexanone Derivatives Containing Quaternary Carbon Center.

    Science.gov (United States)

    Ghorai, Manas K; Halder, Sandipan; Das, Subhomoy

    2015-10-02

    A simple strategy for the synthesis of highly functionalized cyclohexanone derivatives containing an all-carbon quaternary center from α-(aryl/alkyl)methylidene-β-keto esters or β-diketones via a K-enolate mediated domino Michael-Michael reaction sequence with moderate to good yield and excellent diastereoselectivity (de > 99%) is described. Interestingly, Li-base mediated reaction of α-arylmethylidene-β-diketones affords functionalized 3,5-dihydroxy cyclohexane derivatives as the kinetically controlled products via a domino aldol-aldol reaction sequence with excellent diastereoselectivity. Li-enolates of the β-keto esters or β-diketones undergo facile domino Michael-Michael reaction with nitro-olefins to afford the corresponding nitrocyclohexane derivatives in good yields and excellent diastereoselectivity (de > 99%). The formation of the products and the observed stereoselectivity were explained by plausible mechanisms and supported by extensive computational study. An asymmetric version of the protocol was explored with (L)-menthol derived nonracemic substrates, and the corresponding nonracemic cyclohexanone derivatives containing an all-carbon quaternary center were obtained with excellent stereoselectivity (de, ee > 99%).

  19. The Effects of External Focus of Attention on Shoulder Muscle Activities during Forehand Drive in Table Tennis

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Hatami

    2016-06-01

    Full Text Available Objective: The aim of this study was to evaluate the impact of the external focus of attention on the rotator cuff muscle activity for the timely hit forehand drive by table tennis players. Methods: Twelve professional table tennis players with mean age of 26.5 years voluntarily participated in this study. The electrical activities of the muscles of the shoulder girdle using M.A 300 machine and bipolar electrodes surface under two conditions .First with external focus of attention and then without such attention were recorded, first without any guidance blows forehand drive was carried out by subjects (without focus. Then such subject was asked to focus their attention on the area marked for the ball landing (external focus of attention.      Muscle activities in both preparation and tapping phases were analyzed the three –dimensional (200 Hz, Vicon, with four camera series T motion analysis system was used to obtain the data. Data was analyzed by running reported measures ANOVA at a significance level of p0.05 but the different between the intensity of muscle activity was meaningful. This suggests that there is a mutual influence between the two attention factors and muscles (p=0.03, that is, orientation can have a significant effect on the severity of muscle contraction. Intensities of muscle contraction in the preparation and tapping were different (p<0.05. Conclusion: On the forehand drive technique, the anterior deltoid muscle has the most activity. The type of focus and attention had a significant impact on the change of activity of muscles relative to each other, and the greatest impact is on the reduction of activity of the infraspinatus muscle. This type of focus delays fatigue and results in an increase in the efficiency of neuromuscular in the activities of skills.

  20. A Study Of The Effect Of Human Soul On External Objects : Between Copenhagen School And Mulla Sadra

    Directory of Open Access Journals (Sweden)

    Ali Arshad Riahi

    2015-06-01

    Full Text Available Abstract : The theory of the effects of all human souls on external objects, from the viewpoint of Copenhagen School (in Quantum Physics, has made physicists deny the existence of two separate realms of the observer and the observed; they claim that causality is meaningless and profess that it is impossible to recognize the object. While, on the other hand, Mulla Ṣadra believes that the effect of soul on external objects is limited to the souls of prophets as well as saints and, barring evil eye or supplications, there is no such effect in others. In this article we argue that, based on Mulla Ṣadra’s teachings and philosophical doctrine, it is actually possible to generalize this effect to other human souls. Consequently, it is impossible to have an accurate recognition of the causes of events if causality is considered meaningless. In addition, it is feasible to have cognition about these causes of events through gnostic intuition.Keywords : human soul, external objects, Copenhagen School, Mulla Ṣadra, unity, causality Abstrak :  Teori tentang efek jiwa seluruh manusia terhadap objek-objek eksternal, dari sudut pandang Madzhab Copenhagen (dalam Fisika Kuantum, telah membuat para fisikawan mengingkari keterpisahan dua alam, yaitu subjek dan objek; berdasarkan keyakinan ini, mereka mengklaim bahwa [hukum] kausalitas menjadi gugur dan tidak berguna, dan mereka juga percaya bahwa mengetahui sepenuhnya objek adalah tidak mungkin. Sementara, di tempat lain, Mulla Ṣadra meyakini bahwa jiwa yang berefek terhadap objek-objek eksternal terbatas pada jiwa para nabi dan orang-orang suci. Ia juga meyakini bahwa tidak berefeknya jiwa-jiwa manusia biasa kecuali pada perbuatan-perbuatan seperti yang ia sebut sebagai ‘evil eye’ dan doa. Dalam artikel ini, kami berupaya membuktikan bahwa, berdasarkan ajaran dan doktrin filsafat Mulla Ṣadra, pengaruh (efek jiwa manusia dapat digeneralisir. Dengan demikian tidak mungkin untuk mengetahui secara